icdo.owl
type: Ontology
definition: ICDO: International Classification of Diseases Ontology
contributor: Edison Ong
created by: Grace Whah
created by: Jennifer Roman
created by: Justin Song
created by: Ling Wan (Eric)
created by: Oliver He
created by: Virginia He
creation date: 11-4-2022
version info: 1.0.83
license: http://creativecommons.org/licenses/by/4.0/

BFO OWL specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only
sub property of: label

editor preferred term
type: AnnotationProperty
editor preferred term: editor preferred term
has curation status: ready for release
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

example of usage
type: AnnotationProperty
has curation status: ready for release

has curation status
type: AnnotationProperty
editor preferred term: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

definition
type: AnnotationProperty
editor preferred term: definition
has curation status: ready for release
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

editor note
type: AnnotationProperty
editor preferred term: editor note
has curation status: ready for release
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: true
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred term: term editor
has curation status: ready for release
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
has curation status: pending final vetting

definition source
type: AnnotationProperty
editor preferred term: definition source
has curation status: ready for release
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

curator note
type: AnnotationProperty
editor preferred term: curator note
has curation status: ready for release
definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: true
shorthand: curator_notes
label: curator notes

imported from
type: AnnotationProperty
has curation status: pending final vetting

expand expression to
type: AnnotationProperty

OBO foundry unique label
type: AnnotationProperty
has curation status: pending final vetting

elucidation
type: AnnotationProperty

has associated axiom(nl)
type: AnnotationProperty

has associated axiom(fol)
type: AnnotationProperty

has gbt_14396 code
type: AnnotationProperty

has icd11 code
type: AnnotationProperty

has_alternative_id in icd10
type: AnnotationProperty

has icd10 code
type: AnnotationProperty

has icd9 code
type: AnnotationProperty

code billability
type: AnnotationProperty
definition: An annotation property that indicates whether the code is specific enough to be used as a billable medical code.
definition editor: Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/Rules/Billable_Specific_Codes
comment: The following 72,186 ICD-10-CM codes are billable/specific and can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code. Reference: https://www.icd10data.com/ICD10CM/Codes/Rules/Billable_Specific_Codes

temporal interpretation
type: AnnotationProperty
definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
sub property of: logical macro assertion on an object property

dubious_for_taxon
type: AnnotationProperty
definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
database_cross_reference: RO:0002174
has_obo_namespace: uberon
id: dubious_for_taxon
is class level: true
is metadata tag: true
shorthand: dubious_for_taxon
comment: this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost

present_in_taxon
type: AnnotationProperty
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
database_cross_reference: RO:0002175
has_exact_synonym: applicable for taxon
has_obo_namespace: uberon
id: present_in_taxon
is class level: true
is metadata tag: true
shorthand: present_in_taxon

logical macro assertion
type: AnnotationProperty
definition: An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.

logical macro assertion on a property
type: AnnotationProperty
definition: A logical macro assertion whose domain is an IRI for a property
sub property of: logical macro assertion

logical macro assertion on an object property
type: AnnotationProperty
definition: Used to annotate object properties to describe a logical meta-property or characteristic of the object property.
sub property of: logical macro assertion on a property

logical macro assertion on an annotation property
type: AnnotationProperty
sub property of: logical macro assertion on a property

is direct form of
type: AnnotationProperty
definition: relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
editor note: The general property hierarchy is: "directly P" SubPropertyOf "P" Transitive(P) Where we have an annotation assertion "directly P" "is direct form of" "P"
logical macro assertion on an annotation property: If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
creator: Chris Mungall
sub property of: logical macro assertion on an object property

is indirect form of
type: AnnotationProperty
definition: relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y
creator: Chris Mungall
sub property of: logical macro assertion on an object property

is opposite of
type: AnnotationProperty
database_cross_reference: RO:0002604
has_obo_namespace: quality
id: is_opposite_of
is class level: true
is metadata tag: true
shorthand: is_opposite_of

is directional form of
type: AnnotationProperty
definition: Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be "+", "-" or "0"
created by: cjm
creation date: 2018-03-13T23:59:29Z
sub property of: logical macro assertion on an object property

is positive form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-14T00:03:16Z
sub property of: is directional form of

is negative form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-14T00:03:24Z
sub property of: is directional form of

is homeomorphic for
type: AnnotationProperty
example of usage: part-of is homeomorphic for independent continuants.
definition: R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C.
created by: cjm
creation date: 2018-10-21T19:46:34Z
comment: R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C.
sub property of: logical macro assertion on an object property

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
definition: A textual description of an axiom loss in this ontology compared to an external ontology.
database_cross_reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: true
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

implements_design_pattern
type: AnnotationProperty
database_cross_reference: UBPROP:0000006
has_obo_namespace: uberon
id: implements_design_pattern
is metadata tag: true
shorthand: implements_design_pattern

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: true
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: true
shorthand: taxon_notes

function_notes
type: AnnotationProperty
definition: Notes on the evolved function of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000009
has_obo_namespace: uberon
id: function_notes
is metadata tag: true
shorthand: function_notes

structure_notes
type: AnnotationProperty
definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: true
shorthand: structure_notes

development_notes
type: AnnotationProperty
definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: true
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: true
shorthand: external_ontology_notes

terminology_notes
type: AnnotationProperty
definition: Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000013
has_obo_namespace: uberon
id: terminology_notes
is metadata tag: true
shorthand: terminology_notes

fma_set_term
type: AnnotationProperty
external_ontology_notes: FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
database_cross_reference: UBPROP:0000202
has_obo_namespace: uberon
id: fma_set_term
is metadata tag: true
shorthand: fma_set_term

anatomical location
type: AnnotationProperty

has ICD10 name
type: AnnotationProperty

is part of
type: AnnotationProperty

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_narrow_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

in_subset
type: AnnotationProperty

shorthand
type: AnnotationProperty

isDefinedBy
type: AnnotationProperty
OBO foundry unique label: is defined by

see also
type: AnnotationProperty
has_obo_namespace: uberon
id: seeAlso
is metadata tag: true
shorthand: seeAlso

depicted by
type: AnnotationProperty
has_obo_namespace: uberon
id: depicted_by
is metadata tag: true
shorthand: depicted_by

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
editor preferred term: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
alternative term: part_of
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times
is homeomorphic for: continuant
is homeomorphic for: occurrent
is homeomorphic for: independent continuant
is homeomorphic for: realizable entity
is homeomorphic for: quality
is homeomorphic for: specifically dependent continuant
is homeomorphic for: generically dependent continuant

has part
type: ObjectProperty
sub property of: overlaps
type: TransitiveProperty
editor preferred term: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
alternative term: has_part
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times

realized in
type: ObjectProperty
inverse of: realizes
domain: realizable entity
range: process
editor preferred term: realized in
example of usage: this disease is realized in this disease course
example of usage: this fragility is realized in this shattering
example of usage: this investigator role is realized in this investigation
alternative term: is realized by
alternative term: realized_in
imported from: OBO Relations Ontology
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

realizes
type: ObjectProperty
domain: process
range: realizable entity
editor preferred term: realizes
example of usage: this disease course realizes this disease
example of usage: this investigation realizes this investigator role
example of usage: this shattering realizes this fragility
imported from: OBO Relations Ontology
elucidation: to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

preceded by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
editor preferred term: preceded by
definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
editor note: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
alternative term: is preceded by
alternative term: preceded_by
imported from: OBO Relations Ontology
source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
in_subset: ro-eco

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
editor preferred term: precedes
definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
imported from: OBO Relations Ontology
in_subset: ro-eco

occurs in
type: ObjectProperty
inverse of: contains process
domain: occurrent
range: independent continuant
property chain axiom: part of
editor preferred term: occurs in
definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
imported from: OBO Relations Ontology
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
editor preferred term: site of
definition: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
imported from: OBO Relations Ontology
comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant

DP occurs in anatomical lateral side
type: ObjectProperty
sub property of: occurs in
example of usage: A disease process may occurs in the left side of ear. In this case, the domain is the disease process, and the range is the left side.
definition editor: An object property that represents a relation between a disease process (i.e., DP) and the lateral side of an anatomical entity where the disease process occurs.
definition editor: Eric Wan, Oliver He

has syndrome
type: ObjectProperty

has DP material quality
type: ObjectProperty

caused by
type: ObjectProperty

has DP output
type: ObjectProperty
definition: An object property that represents a relation between a disease process and a material entity where the disease process has the material entity as a typically abnormal material output.
definition editor: Eric Wan, Oliver He

has process profile
type: ObjectProperty
definition: An object property that represents a relation between a process and a process profile where the process has the process profile.
definition editor: Oliver He
alternative term: has profile

inheres in
type: ObjectProperty
sub property of: inheres in part of
inverse of: bearer of
editor preferred term: inheres in
example of usage: this fragility inheres in this vase
example of usage: this red color inheres in this apple
definition: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
editor note: A dependent inheres in its bearer at all times for which the dependent exists.
alternative term: inheres_in
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times

bearer of
type: ObjectProperty
range: specifically dependent continuant
editor preferred term: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer_of
alternative term: is bearer of
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
editor preferred term: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
alternative term: participates_in
imported from: OBO Relations Ontology

has participant
type: ObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
property chain axiom: realizes
property chain axiom: inheres in
editor preferred term: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
imported from: OBO Relations Ontology
source: http://www.obofoundry.org/ro/#OBO_REL:has_participant

has function
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: function
example of usage: this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
editor note: A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
alternative term: has_function
imported from: OBO Relations Ontology

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
example of usage: this apple has quality this red color
definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality
imported from: OBO Relations Ontology

has role
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: role
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
alternative term: has_role
imported from: OBO Relations Ontology

has disposition
type: ObjectProperty
sub property of: bearer of
inverse of: disposition of
domain: independent continuant
range: disposition
definition: a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence
imported from: OBO Relations Ontology

disposition of
type: ObjectProperty
sub property of: inheres in
definition: inverse of has disposition
imported from: OBO Relations Ontology
in_subset: RO_0002259

is allergic trigger for
type: ObjectProperty
sub property of: causes or contributes to condition
inverse of: has allergic trigger
domain: material entity
example of usage: penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520)
definition: A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.
imported from: OBO Relations Ontology

is autoimmune trigger for
type: ObjectProperty
sub property of: causes or contributes to condition
inverse of: has autoimmune trigger
domain: material entity
definition: A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.
imported from: OBO Relations Ontology

has allergic trigger
type: ObjectProperty
sub property of: causes or contributes to condition
range: material entity
example of usage: penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334)
definition: A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.
imported from: OBO Relations Ontology

has autoimmune trigger
type: ObjectProperty
sub property of: causes or contributes to condition
range: material entity
definition: A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity.
imported from: OBO Relations Ontology

regulates in other organism
type: ObjectProperty
sub property of: causally upstream of or within
domain: process
range: process
definition: x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2).
definition editor: David Osumi-Sutherland
imported from: OBO Relations Ontology

occurent part of
type: ObjectProperty
sub property of: part of
sub property of: causally upstream of or within
domain: occurrent
range: occurrent
definition: A part of relation that applies only between occurents.
imported from: OBO Relations Ontology

has regulatory component activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulated by
definition: A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:30:46Z

has negative regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: negatively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:31:01Z
comment: By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.

has positive regulatory component activity
type: ObjectProperty
sub property of: has regulatory component activity
sub property of: positively regulated by
definition: A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:31:17Z
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.

has necessary component activity
type: ObjectProperty
sub property of: has component activity
sub property of: positively regulated by
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:36:08Z
comment: A has necessary component activity B if A and B are GO molecular functions (GO_0003674), A has_component B and B is necessary for A. For example, ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity.

has component activity
type: ObjectProperty
sub property of: has component process
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:44:33Z
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.

has component process
type: ObjectProperty
sub property of: has component
domain: process
range: process
definition: w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-05-24T09:49:21Z

has ligand
type: ObjectProperty
sub property of: has input
definition: A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-07-19T17:30:36Z

transports
type: ObjectProperty
sub property of: transports or maintains localization of
definition: Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-07-20T17:11:08Z

directly regulated by
type: ObjectProperty
sub property of: regulated by
inverse of: directly regulates
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-09-17T13:52:24Z
comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.

directly negatively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly negatively regulates
definition: Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-09-17T13:52:38Z

directly positively regulated by
type: ObjectProperty
sub property of: directly regulated by
inverse of: directly positively regulates
definition: Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-09-17T13:52:47Z

has effector activity
type: ObjectProperty
sub property of: has component activity
sub property of: regulates
type: FunctionalProperty
definition: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
imported from: OBO Relations Ontology
created by: dos
creation date: 2017-09-22T14:14:36Z
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends during
property chain axiom: preceded by
definition editor: David Osumi-Sutherland
imported from: OBO Relations Ontology
in_subset: ro-eco
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately preceded by
type: ObjectProperty
sub property of: preceded by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
definition editor: David Osumi-Sutherland
alternative term: starts_at_end_of
imported from: OBO Relations Ontology
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with
definition editor: David Osumi-Sutherland
alternative term: ends_at_start_of
alternative term: meets
imported from: OBO Relations Ontology
is direct form of: precedes
in_subset: ro-eco
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition editor: David Osumi-Sutherland
alternative term: io
imported from: OBO Relations Ontology
in_subset: ro-eco
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: ends during
type: TransitiveProperty
definition editor: David Osumi-Sutherland
alternative term: d
alternative term: during
imported from: OBO Relations Ontology
in_subset: ro-eco
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends during
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: o
alternative term: overlaps
imported from: OBO Relations Ontology
in_subset: ro-eco
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
property chain axiom: part of
property chain axiom: has part
has curation status: pending final vetting
definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
imported from: OBO Relations Ontology
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
temporal interpretation: axiom holds for all times
in_subset: ro-eco

connected to
type: ObjectProperty
sub property of: mereotopologically related to
domain: Restriction
  on property: part of
  some values from: system
range: Restriction
  on property: part of
  some values from: system
property chain axiom:
  inverse of: connects
property chain axiom: connects
example of usage: a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
definition: a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: OBO Relations Ontology

connects
type: ObjectProperty
sub property of: mereotopologically related to
domain: independent continuant
range: Restriction
  on property: part of
  some values from: system
example of usage: The M8 connects Glasgow and Edinburgh
example of usage: a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
definition: c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: OBO Relations Ontology

drains
type: ObjectProperty
sub property of: connected to
definition: Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
editor note: Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: OBO Relations Ontology

has component
type: ObjectProperty
sub property of: has part
has curation status: pending final vetting
definition: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
editor note: The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
curator note: For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times
in_subset: ro-eco

has phenotype
type: ObjectProperty
sub property of: topObjectProperty
inverse of: phenotype of
domain: Class
  union of: generically dependent continuant
  union of: material anatomical entity
  union of: disease
range: phenotype
has curation status: pending final vetting
definition: A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype).
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: ro-eco

phenotype of
type: ObjectProperty
sub property of: topObjectProperty
type: FunctionalProperty
has curation status: pending final vetting
definition: inverse of has phenotype
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: RO_0002259
in_subset: ro-eco

regulates
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: ends with
property chain axiom: directly regulates
has curation status: pending final vetting
definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
editor note: We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
definition editor: Chris Mungall
definition editor: David Hill
definition editor: Tanya Berardini
definition source: causal-relations
definition source: GO
curator note: Regulation precludes parthood; the regulatory process may not be within the regulated process.
imported from: OBO Relations Ontology
OBO foundry unique label: regulates (processual)
elucidation: false

negatively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
property chain axiom: ends with
definition: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: negatively regulates (process to process)
is negative form of: regulates

positively regulates
type: ObjectProperty
sub property of: regulates
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
property chain axiom: ends with
definition: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: positively regulates (process to process)
is positive form of: regulates

has prototype
type: ObjectProperty
domain: Class
  union of: independent continuant
  union of: process
example of usage: 'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair'))
example of usage: heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation')
has curation status: pending final vetting
definition: x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation.
editor note: Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from)
editor note: TODO: add homeomorphy axiom
editor note: This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants.
definition editor: Chris Mungall
imported from: OBO Relations Ontology

capable of
type: ObjectProperty
sub property of: capable of part of
domain: independent continuant
range: process
example of usage: mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
example of usage: osteoclast SubClassOf 'capable of' some 'bone resorption'
definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
definition editor: Chris Mungall
alternative term: has function realized in
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20123131
definition source: http://www.ncbi.nlm.nih.gov/pubmed/21208450
curator note: For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
imported from: OBO Relations Ontology
expand expression to: RO_0000053 some (RO_0000054 only ?Y)
in_subset: ro-eco

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: part of
definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
definition editor: Chris Mungall
alternative term: has function in
imported from: OBO Relations Ontology
expand expression to: RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))

obsolete has active participant
type: ObjectProperty
sub property of: has participant
example of usage: 'heart development' has active participant some Shh protein
has curation status: pending final vetting
definition: x has participant y if and only if x realizes some active role that inheres in y
editor note: This may be obsoleted and replaced by the original 'has agent' relation
definition editor: Chris Mungall
alternative term: has agent
imported from: OBO Relations Ontology
in_subset: ro-eco
deprecated: true

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
has curation status: pending final vetting
definition editor: Chris Mungall
definition source: Allen's interval algebra
curator note: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
imported from: OBO Relations Ontology
source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in_subset: ro-eco
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
example of usage: Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
has curation status: pending final vetting
definition: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: started by
imported from: OBO Relations Ontology
in_subset: ro-eco

ends with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
has curation status: pending final vetting
definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: Chris Mungall
alternative term: finished by
imported from: OBO Relations Ontology
in_subset: ro-eco

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
domain: process
range: material entity
property chain axiom: starts with
has curation status: pending final vetting
definition: p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
definition editor: Chris Mungall
alternative term: consumes
imported from: OBO Relations Ontology
in_subset: ro-eco

has output
type: ObjectProperty
sub property of: has participant
inverse of: output of
property chain axiom: ends with
has curation status: pending final vetting
definition: p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.
definition editor: Chris Mungall
alternative term: produces
imported from: OBO Relations Ontology
in_subset: ro-eco

has exposure receptor
type: ObjectProperty
sub property of: related via exposure to
definition: A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event.
definition source: ExO:0000001
imported from: OBO Relations Ontology

has exposure stressor
type: ObjectProperty
sub property of: has exposure stimulus
definition: A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event.
definition source: ExO:0000000
imported from: OBO Relations Ontology

has exposure route
type: ObjectProperty
sub property of: related via exposure to
definition: A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor
definition source: ExO:0000055
imported from: OBO Relations Ontology

has exposure transport path
type: ObjectProperty
sub property of: related via exposure to
definition: A broad relationship between an exposure event or process and the course takes from the source to the target.
definition source: http://purl.obolibrary.org/obo/ExO_0000004
imported from: OBO Relations Ontology

related via exposure to
type: ObjectProperty
sub property of: causally related to
domain: exposure event or process
definition: Any relationship between an exposure event or process and any other entity.
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes.
imported from: OBO Relations Ontology

has biological role
type: ObjectProperty
sub property of: has role
definition: c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432)
imported from: OBO Relations Ontology

has application role
type: ObjectProperty
sub property of: has role
definition: c has-application-role r iff c has-role r and r is an application role (CHEBI:33232)
imported from: OBO Relations Ontology

has chemical role
type: ObjectProperty
sub property of: has role
definition: c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086)
imported from: OBO Relations Ontology

acts upstream of
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of
example of usage: A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.
definition: c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.
imported from: OBO Relations Ontology

acts upstream of or within
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: enables
property chain axiom: causally upstream of or within
example of usage: A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.
definition: c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
imported from: OBO Relations Ontology
has_related_synonym: affects

results in developmental progression of
type: ObjectProperty
sub property of: developmentally related to
domain: biological_process
range: connected anatomical structure
has curation status: pending final vetting
definition: p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
editor note: This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
definition editor: Chris Mungall
imported from: OBO Relations Ontology
shorthand: results_in_developmental_progression_of

results in development of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
example of usage: every flower development (GO:0009908) results in development of some flower (PO:0009046)
has curation status: pending final vetting
definition: p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state.
definition editor: Chris Mungall
definition source: http://www.geneontology.org/GO.doc.development.shtml
imported from: OBO Relations Ontology
shorthand: results_in_development_of

results in formation of
type: ObjectProperty
sub property of: has output
sub property of: results in developmental progression of
inverse of: formed as result of
example of usage: an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists.
example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062)
has curation status: pending final vetting
definition editor: Chris Mungall
definition source: GOC:mtg_berkeley_2013
imported from: OBO Relations Ontology
shorthand: results_in_formation_of

results in morphogenesis of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
example of usage: an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape.
example of usage: tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723)
has curation status: pending final vetting
definition: The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.
definition editor: Chris Mungall
definition source: GOC:mtg_berkeley_2013
imported from: OBO Relations Ontology
shorthand: results_in_morphogenesis_of

results in maturation of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
example of usage: an annotation of gene X to cell maturation with results_in_maturation_of CL:0000057 (fibroblast) means that the fibroblast is mature at the end of the process
example of usage: bone maturation (GO:0070977) results_in_maturation_of bone (UBERON:0001474)
has curation status: pending final vetting
definition: The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity.
definition editor: Chris Mungall
definition source: GOC:mtg_berkeley_2013
imported from: OBO Relations Ontology
shorthand: results_in_maturation_of

results in disappearance of
type: ObjectProperty
sub property of: results in ending of
example of usage: foramen ovale closure SubClassOf results in disappearance of foramen ovale
has curation status: pending final vetting
definition editor: Chris Mungall
curator note: May be merged into parent relation
imported from: OBO Relations Ontology
shorthand: results_in_disappearance_of

results in developmental regression of
type: ObjectProperty
sub property of: results in ending of
example of usage: every mullerian duct regression (GO:0001880) results in regression of some mullerian duct (UBERON:0003890)
has curation status: pending final vetting
definition editor: Chris Mungall
curator note: May be merged into parent relation
imported from: OBO Relations Ontology

is treated by substance
type: ObjectProperty
sub property of: causally related to
inverse of: is substance that treats
definition: Inverse of 'is substance that treats'
imported from: OBO Relations Ontology
creator: cjm
in_subset: RO_0002259

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, positive effect
imported from: OBO Relations Ontology
is positive form of: causally upstream of
creator: cjm
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, negative effect
imported from: OBO Relations Ontology
is negative form of: causally upstream of
creator: cjm
comment: holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y

has exposure stimulus
type: ObjectProperty
sub property of: related via exposure to
definition: A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event.
imported from: OBO Relations Ontology
contributor: Austin Meier
contributor: Chris Mungall
contributor: Marie Angelique Laporte
created by: cjm
creation date: 2017-06-05T17:35:04Z

transports or maintains localization of
type: ObjectProperty
sub property of: related via localization to
sub property of: has anatomical participant
property chain axiom: has part
definition: Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c.
definition editor: Chris Mungall
alternative term: regulates localization of
imported from: OBO Relations Ontology

inheres in part of
type: ObjectProperty
sub property of: depends on
property chain axiom: inheres in
property chain axiom: part of
definition: q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.
editor note: Because part_of is transitive, inheres in is a sub-relation of inheres in part of
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times

results in acquisition of features of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
range: connected anatomical structure
example of usage: an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
definition: The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
definition editor: Chris Mungall
definition source: GOC:mtg_berkeley_2013
imported from: OBO Relations Ontology
shorthand: results_in_acquisition_of_features_of

mereotopologically related to
type: ObjectProperty
definition: A mereological relationship or a topological relationship
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
imported from: OBO Relations Ontology
temporal interpretation: axiom holds for all times

developmentally related to
type: ObjectProperty
definition: A relationship that holds between entities participating in some developmental process (GO:0032502)
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development
imported from: OBO Relations Ontology

contributes to
type: ObjectProperty
sub property of: capable of part of
sub property of: part of structure that is capable of
example of usage: ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity.
example of usage: Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity.
example of usage: eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to "ribosome binding". And all three are part_of an eIF2 complex
editor note: We would like to say if and only if exists c', p' c part_of c' and c' capable_of p and c capable_of p' and p' part_of p then c contributes_to p However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction.
definition editor: Chris Mungall
definition source: http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to
curator note: In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology.
imported from: OBO Relations Ontology

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
property chain axiom: has part
property chain axiom: has component activity
example of usage: a particular instances of akt-2 enables some instance of protein kinase activity
definition editor: Chris Mungall
alternative term: catalyzes
alternative term: executes
alternative term: has
alternative term: is catalyzing
alternative term: is executing
curator note: This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
curator note: This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.
imported from: OBO Relations Ontology

functionally related to
type: ObjectProperty
definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
definition editor: Chris Mungall
curator note: This is a grouping relation that collects relations used for the purpose of connecting structure and function
imported from: OBO Relations Ontology

part of structure that is capable of
type: ObjectProperty
sub property of: functionally related to
property chain axiom: part of
property chain axiom: capable of
definition: this relation holds between c and p when c is part of some c', and c' is capable of p.
definition editor: Chris Mungall
alternative term: false
imported from: OBO Relations Ontology

involved in
type: ObjectProperty
sub property of: participates in
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: part of
definition: c involved_in p if and only if c enables some process p', and p' is part of p
definition editor: Chris Mungall
alternative term: actively involved in
alternative term: enables part of
imported from: OBO Relations Ontology

enabled by
type: ObjectProperty
sub property of: has participant
sub property of: functionally related to
definition: inverse of enables
definition editor: Chris Mungall
imported from: OBO Relations Ontology

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
definition: inverse of regulates
definition editor: Chris Mungall
imported from: OBO Relations Ontology
OBO foundry unique label: regulated by (processual)
in_subset: RO_0002259

negatively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of negatively regulates
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: RO_0002259

positively regulated by
type: ObjectProperty
sub property of: regulated by
definition: inverse of positively regulates
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: RO_0002259

related via localization to
type: ObjectProperty
domain: process
range: continuant
definition: A relationship that holds via some process of localization
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is a grouping relation.
imported from: OBO Relations Ontology

imports
type: ObjectProperty
sub property of: transports
property chain axiom: has part
definition: Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s.
definition editor: Chris Mungall
imported from: OBO Relations Ontology

results in growth of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
example of usage: 'pollen tube growth' results_in growth_of some 'pollen tube'
definition editor: Chris Mungall
imported from: OBO Relations Ontology

exports
type: ObjectProperty
sub property of: transports
property chain axiom: has part
definition editor: Chris Mungall
imported from: OBO Relations Ontology

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has input
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: RO_0002259
in_subset: ro-eco

output of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
definition: inverse of has output
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: RO_0002259
in_subset: ro-eco

formed as result of
type: ObjectProperty
sub property of: output of
definition editor: Chris Mungall
imported from: OBO Relations Ontology

results in structural organization of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
definition: A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity.
definition editor: Chris Mungall
imported from: OBO Relations Ontology

has direct input
type: ObjectProperty
sub property of: has input
property chain axiom: starts with
example of usage: 'protein catabolic process' SubClassOf has_direct_input some protein
has curation status: requires discussion
definition: p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p.
definition editor: Chris Mungall
alternative term: directly consumes
curator note: This is likely to be obsoleted. A candidate replacement would be a new relation 'has bound input' or 'has substrate'
imported from: OBO Relations Ontology

obsolete has direct output
type: ObjectProperty
example of usage: translation SubClassOf has_direct_output some protein
has curation status: requires discussion
definition: p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c.
definition editor: Chris Mungall
alternative term: directly produces
imported from: OBO Relations Ontology
deprecated: true

causally downstream of
type: ObjectProperty
sub property of: preceded by
sub property of: causally downstream of or within
inverse of: causally upstream of
has curation status: requires discussion
definition: inverse of upstream of
definition editor: Chris Mungall
imported from: OBO Relations Ontology

immediately causally downstream of
type: ObjectProperty
sub property of: immediately preceded by
sub property of: causally downstream of
inverse of: immediately causally upstream of
has curation status: requires discussion
definition editor: Chris Mungall
imported from: OBO Relations Ontology

directly activates
type: ObjectProperty
sub property of: directly positively regulates
has curation status: requires discussion
definition: p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q
definition editor: Chris Mungall
alternative term: directly positively regulates
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly activates (process to process)

indirectly activates
type: ObjectProperty
sub property of: positively regulates
type: TransitiveProperty
property chain axiom: directly activates
property chain axiom: indirectly inhibits
definition: p indirectly activates q if and only if p is upstream of q and there is a chain of directly activates relationships connecting p and q, where the chain is of length greater than one.
definition editor: Chris Mungall
alternative term: indirectly positively regulates
imported from: OBO Relations Ontology
is indirect form of: positively regulates

directly inhibits
type: ObjectProperty
sub property of: directly negatively regulates
definition editor: Chris Mungall
alternative term: directly negatively regulates
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly inhibits (process to process)

indirectly inhibits
type: ObjectProperty
sub property of: negatively regulates
type: TransitiveProperty
property chain axiom: directly inhibits
has curation status: requires discussion
definition editor: Chris Mungall
alternative term: indirectly negatively regulates
imported from: OBO Relations Ontology
is indirect form of: negatively regulates

causally related to
type: ObjectProperty
has curation status: requires discussion
definition: This relation groups causal relations between material entities and causal relations between processes
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yiel…
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: OBO Relations Ontology

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
has curation status: requires discussion
definition: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
definition editor: Chris Mungall
imported from: OBO Relations Ontology

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
has curation status: requires discussion
definition: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
definition editor: Chris Mungall
imported from: OBO Relations Ontology
is direct form of: causally upstream of

directly provides input for
type: ObjectProperty
sub property of: immediately causally upstream of
sub property of: transitively provides input for
property chain axiom: obsolete has direct output
property chain axiom: has direct input
has curation status: requires discussion
definition: p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c
editor note: This is currently called 'directly provides input for' to be consistent with our terminology where we use 'direct' whenever two occurrents succeed one another directly. We may relabel this simply 'provides input for', as directness is implicit
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly provides input for (process to process)

transitively provides input for
type: ObjectProperty
sub property of: causally upstream of
type: TransitiveProperty
domain: process
range: process
has curation status: requires discussion
definition: transitive form of directly_provides_input_for
definition editor: Chris Mungall
curator note: This is a grouping relation that should probably not be used in annotation. Consider instead the child relation 'directly provides input for' (which may later be relabeled simply to 'provides input for')
imported from: OBO Relations Ontology
OBO foundry unique label: transitively provides input for (process to process)

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
editor note: We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
definition editor: Chris Mungall
alternative term: influences (processual)
imported from: OBO Relations Ontology
has_related_synonym: affects

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
definition: inverse of causally upstream of or within
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
in_subset: RO_0002259

involved in regulation of
type: ObjectProperty
sub property of: acts upstream of
sub property of: involved in or involved in regulation of
property chain axiom: enables
property chain axiom: regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' regulates some p
definition editor: Chris Mungall
imported from: OBO Relations Ontology

involved in positive regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: positively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' positively regulates some p
definition editor: Chris Mungall
imported from: OBO Relations Ontology
is positive form of: involved in regulation of

involved in negative regulation of
type: ObjectProperty
sub property of: involved in regulation of
property chain axiom: enables
property chain axiom: negatively regulates
property chain axiom: involved in
definition: c involved in regulation of p if c is involved in some p' and p' negatively regulates some p
definition editor: Chris Mungall
imported from: OBO Relations Ontology
is negative form of: involved in regulation of

involved in or involved in regulation of
type: ObjectProperty
sub property of: acts upstream of or within
sub property of: functionally related to
sub property of: causal agent in process
definition: c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p
editor note: OWL does not allow defining object properties via a Union
definition editor: Chris Mungall
alternative term: involved in or reguates
imported from: OBO Relations Ontology

interacts with
type: ObjectProperty
type: SymmetricProperty
domain: material entity
range: material entity
definition: A relationship that holds between two entities in which the processes executed by the two entities are causally connected.
editor note: Considering relabeling as 'pairwise interacts with'
editor note: This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.
definition editor: Chris Mungall
curator note: Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.
imported from: OBO Relations Ontology
has_exact_synonym: in pairwise interaction with
in_subset: ro-eco

molecularly interacts with
type: ObjectProperty
sub property of: interacts with
type: SymmetricProperty
definition: An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.
definition editor: Chris Mungall
alternative term: binds
alternative term: molecularly binds with
imported from: OBO Relations Ontology

directly regulates activity of
type: ObjectProperty
sub property of: molecularly interacts with
sub property of: regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.
definition editor: Chris Mungall
definition editor: Vasundra Touré
imported from: OBO Relations Ontology
has_exact_synonym: molecularly controls

directly negatively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly negatively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
definition editor: Chris Mungall
definition editor: Vasundra Touré
alternative term: directly inhibits
imported from: OBO Relations Ontology
has_exact_synonym: molecularly decreases activity of

directly positively regulates activity of
type: ObjectProperty
sub property of: directly regulates activity of
domain: material entity
range: material entity
property chain axiom: enables
property chain axiom: directly positively regulates
property chain axiom: enabled by
definition: The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
definition editor: Chris Mungall
definition editor: Vasundra Touré
alternative term: directly activates
imported from: OBO Relations Ontology
has_exact_synonym: molecularly increases activity of

partner in
type: ObjectProperty
sub property of: participates in
definition editor: Chris Mungall
curator note: Experimental: relation used for defining interaction relations. An interaction relation holds when there is an interaction event with two partners. In a directional interaction, one partner is deemed the subject, the other the target
imported from: OBO Relations Ontology

subject participant in
type: ObjectProperty
sub property of: partner in
definition editor: Chris Mungall
curator note: Experimental: relation used for defining interaction relations; the meaning of s 'subject participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the subject is the predator. We can imagine a reciprocal prey-predatory process with subject and object reversed.
imported from: OBO Relations Ontology

target participant in
type: ObjectProperty
sub property of: partner in
definition editor: Chris Mungall
curator note: Experimental: relation used for defining interaction relations; the meaning of s 'target participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the target is the prey. We can imagine a reciprocal prey-predatory process with subject and object reversed.
imported from: OBO Relations Ontology

causal agent in process
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: process has causal agent
definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process
definition source: causal-relations
imported from: OBO Relations Ontology

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: OBO Relations Ontology

depends on
type: ObjectProperty
definition editor: Chris Mungall
imported from: OBO Relations Ontology

has intermediate
type: ObjectProperty
sub property of: has participant
example of usage: 'lysine biosynthetic process via diaminopimelate' SubClassOf has_intermediate some diaminopimelate
definition: p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c
definition editor: Chris Mungall
alternative term: has intermediate product
imported from: OBO Relations Ontology
in_subset: ro-eco

causal relation between entities
type: ObjectProperty
sub property of: causally related to
domain: continuant
range: continuant
editor note: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: OBO Relations Ontology

determined by
type: ObjectProperty
sub property of: part of
sub property of: determined by part of
sub property of: causally influenced by
inverse of: determines
domain: system
range: material entity
example of usage: A coral reef environment is determined by a particular coral reef
definition: s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s.
editor note: The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/24330602
imported from: OBO Relations Ontology
OBO foundry unique label: determined by (system to material entity)
creator: Chris Mungall
creator: Pier Buttigieg
in_subset: ro-eco

determines
type: ObjectProperty
sub property of: causally influences
definition: inverse of determined by
definition editor: Chris Mungall
imported from: OBO Relations Ontology
OBO foundry unique label: determines (material entity to system)
in_subset: RO_0002259
in_subset: ro-eco

determined by part of
type: ObjectProperty
sub property of: overlaps
sub property of: causal relation between entities
domain: system
range: material entity
property chain axiom: determined by
property chain axiom: part of
definition: s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w.
definition editor: Chris Mungall
imported from: OBO Relations Ontology
in_subset: ro-eco

results in ending of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
definition: p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded.
definition editor: Chris Mungall
imported from: OBO Relations Ontology

causally influenced by
type: ObjectProperty
sub property of: causal relation between entities
inverse of: causally influences
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: causally influenced by (entity-centric)

results in movement of
type: ObjectProperty
sub property of: has anatomical participant
definition: Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c
definition editor: Chris Mungall
imported from: OBO Relations Ontology

causally influences
type: ObjectProperty
sub property of: causal relation between entities
domain: continuant
range: continuant
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
definition: The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).
definition editor: Chris Mungall
definition editor: Vasundra Touré
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: causally influences (entity-centric)

directly regulates
type: ObjectProperty
sub property of: regulates
sub property of: immediately causally upstream of
definition: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly regulates (processual)
is direct form of: regulates

has part structure that is capable of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal relation between material entity and a process
property chain axiom: has part
property chain axiom: capable of
example of usage: gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'
definition: s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
definition editor: Chris Mungall
imported from: OBO Relations Ontology

results in closure of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: has anatomical participant
editor note: p 'results in closure of' c if and only if p is a developmental process and p results in a state of c changing from open to closed.
imported from: OBO Relations Ontology

results in breakdown of
type: ObjectProperty
sub property of: has input
definition: p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p
imported from: OBO Relations Ontology

results in synthesis of
type: ObjectProperty
sub property of: results in formation of
imported from: OBO Relations Ontology

results in assembly of
type: ObjectProperty
sub property of: results in formation of
sub property of: results in organization of
imported from: OBO Relations Ontology

results in catabolism of
type: ObjectProperty
sub property of: results in breakdown of
definition: p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released.
imported from: OBO Relations Ontology

results in disassembly of
type: ObjectProperty
sub property of: results in breakdown of
sub property of: results in organization of
imported from: OBO Relations Ontology

results in remodeling of
type: ObjectProperty
sub property of: has input
sub property of: results in organization of
imported from: OBO Relations Ontology

results in organization of
type: ObjectProperty
sub property of: has anatomical participant
definition: p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c
imported from: OBO Relations Ontology

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
editor note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
definition editor: Chris Mungall
definition source: causal-relations
imported from: OBO Relations Ontology

capable of regulating
type: ObjectProperty
sub property of: causal agent in process
property chain axiom: capable of
property chain axiom: regulates
example of usage: pyrethroid -> growth
definition: Holds between c and p if and only if c is capable of some activity a, and a regulates p.
definition source: causal-relations
imported from: OBO Relations Ontology

capable of negatively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: negatively regulates
definition: Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
definition source: causal-relations
imported from: OBO Relations Ontology

capable of positively regulating
type: ObjectProperty
sub property of: capable of regulating
property chain axiom: capable of
property chain axiom: positively regulates
example of usage: renin -> arteriolar smooth muscle contraction
definition: Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
definition source: causal-relations
imported from: OBO Relations Ontology

capable of inhibiting or preventing pathological process
type: ObjectProperty
sub property of: capable of negatively regulating
example of usage: pazopanib -> pathological angiogenesis
definition: Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p.
alternative term: treats
definition source: causal-relations
curator note: The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber.
imported from: OBO Relations Ontology

capable of upregulating or causing pathological process
type: ObjectProperty
sub property of: capable of positively regulating
example of usage: benzene -> cancer [CHEBI]
definition: Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p.
alternative term: causes disease
definition source: causal-relations
imported from: OBO Relations Ontology

is substance that treats
type: ObjectProperty
sub property of: capable of inhibiting or preventing pathological process
definition: c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d.
alternative term: treats
definition source: causal-relations
imported from: OBO Relations Ontology

process has causal agent
type: ObjectProperty
sub property of: causally related to
definition: Inverse of 'causal agent in process'
definition source: causal-relations
imported from: OBO Relations Ontology

directly positively regulates
type: ObjectProperty
sub property of: positively regulates
sub property of: directly regulates
definition: Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly positively regulates (process to process)
is positive form of: directly regulates

directly negatively regulates
type: ObjectProperty
sub property of: negatively regulates
sub property of: directly regulates
definition: Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.
definition source: causal-relations
imported from: OBO Relations Ontology
OBO foundry unique label: directly negatively regulates (process to process)
is negative form of: directly regulates

represses expression of
type: ObjectProperty
sub property of: directly negatively regulates activity of
domain: material entity
range: material entity
definition: Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

increases expression of
type: ObjectProperty
sub property of: directly positively regulates activity of
domain: material entity
range: material entity
definition: Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

causes or contributes to condition
type: ObjectProperty
sub property of: causally related to
example of usage: The genetic variant 'NM_007294.3(BRCA1):c.110C>A (p.Thr37Lys)' casues or contributes to the disease 'familial breast-ovarian cancer'. An environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease 'skin cancer'.
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition.
editor note: Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! 'has phenotype' and RO:0002201 ! 'phenotype of'.
imported from: OBO Relations Ontology
comment: Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.

causes condition
type: ObjectProperty
sub property of: causes or contributes to condition
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition.
imported from: OBO Relations Ontology

contributes to condition
type: ObjectProperty
sub property of: causes or contributes to condition
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition.
imported from: OBO Relations Ontology

contributes to severity of condition
type: ObjectProperty
sub property of: contributes to condition
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual.
alternative term: contributes to expressivity of condition
imported from: OBO Relations Ontology

contributes to frequency of condition
type: ObjectProperty
sub property of: contributes to condition
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population.
alternative term: contributes to penetrance of condition
imported from: OBO Relations Ontology

ameliorates condition
type: ObjectProperty
sub property of: contributes to severity of condition
definition: A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition.
alternative term: is preventative for condition
imported from: OBO Relations Ontology
comment: Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions.

exacerbates condition
type: ObjectProperty
sub property of: contributes to severity of condition
definition: A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition.
imported from: OBO Relations Ontology

condition ameliorated by
type: ObjectProperty
sub property of: causally related to
definition: A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity.
imported from: OBO Relations Ontology

condition exacerbated by
type: ObjectProperty
sub property of: causally related to
definition: A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity.
imported from: OBO Relations Ontology

condition has genetic basis in
type: ObjectProperty
sub property of: causally related to
inverse of: is genetic basis for condition
domain: realizable entity
range: Class
  union of: process
  union of: quality
  union of: material entity
curator note: Do not use this relation directly. It is intended as a grouping for a more specific relations
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:38:20Z

has material basis in gain of function germline mutation in
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal gain of function germline mutation of in
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:45:20Z

has material basis in loss of function germline mutation in
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal loss of function germline mutation of in
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:45:37Z

has material basis in germline mutation in
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal germline mutation in
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:45:54Z

has material basis in somatic mutation in
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal somatic mutation in
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:46:07Z

has major susceptibility factor
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal susceptibility factor for
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:46:26Z

has partial material basis in germline mutation in
type: ObjectProperty
sub property of: condition has genetic basis in
inverse of: is causal germline mutation partially giving rise to
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:46:57Z

has primary input or output
type: ObjectProperty
sub property of: has participant
definition: p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2018-12-13T11:26:17Z

has primary output
type: ObjectProperty
sub property of: has output
sub property of: has primary input or output
definition: p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2018-12-13T11:26:32Z

has primary input
type: ObjectProperty
sub property of: has input
sub property of: has primary input or output
definition: p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2018-12-13T11:26:56Z

is genetic basis for condition
type: ObjectProperty
sub property of: is basis for realizable
range: realizable entity
curator note: Do not use this relation directly. It is intended as a grouping for a more specific relations
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:53:08Z

is causal gain of function germline mutation of in
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:55:51Z

is causal loss of function germline mutation of in
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:56:06Z

is causal germline mutation in
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:56:40Z

is causal somatic mutation in
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:57:07Z

is causal susceptibility factor for
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition and that is necessary but not sufficient to develop the condition[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:57:43Z

is causal germline mutation partially giving rise to
type: ObjectProperty
sub property of: is genetic basis for condition
definition: Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet].
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T02:58:43Z

realizable has basis in
type: ObjectProperty
sub property of: causally related to
inverse of: is basis for realizable
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T03:20:01Z

is basis for realizable
type: ObjectProperty
sub property of: causally related to
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T03:20:29Z

disease has basis in
type: ObjectProperty
sub property of: realizable has basis in
sub property of: causal relationship with disease as subject
domain: disease
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T03:26:47Z

disease has basis in dysfunction of
type: ObjectProperty
sub property of: disease has basis in
range: material anatomical entity
definition: A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function.
imported from: OBO Relations Ontology
OBO foundry unique label: disease has basis in dysfunction of (disease to anatomical structure)
created by: cjm
creation date: 2017-11-05T03:29:32Z

disease has basis in disruption of
type: ObjectProperty
sub property of: disease has basis in
range: process
definition: A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process.
imported from: OBO Relations Ontology
OBO foundry unique label: disease has basis in disruption of (disease to process)
created by: cjm
creation date: 2017-11-05T03:37:52Z

disease has basis in feature
type: ObjectProperty
sub property of: has phenotype
sub property of: disease has basis in
domain: disease
range: Class
  union of: disease
  union of: phenotype
definition: A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T03:46:07Z

causal relationship with disease as subject
type: ObjectProperty
sub property of: causally related to
sub property of: disease relationship
domain: disease
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-11-05T03:50:54Z

disease causes disruption of
type: ObjectProperty
sub property of: causal relationship with disease as subject
domain: disease
range: process
property chain axiom: part of
property chain axiom: disease causes dysfunction of
property chain axiom: capable of
definition: A relationship between a disease and a process where the disease process disrupts the execution of the process.
imported from: OBO Relations Ontology
OBO foundry unique label: disease causes disruption of (disease to process)
created by: cjm
creation date: 2017-11-05T03:51:09Z

disease causes dysfunction of
type: ObjectProperty
sub property of: causal relationship with disease as subject
domain: disease
range: material anatomical entity
property chain axiom: part of
imported from: OBO Relations Ontology
OBO foundry unique label: disease causes dysfunction of (disease to anatomical entity)
created by: cjm
creation date: 2017-11-05T03:58:20Z

realized in response to stimulus
type: ObjectProperty
sub property of: causally related to
domain: realizable entity
range: material entity
property chain axiom: realized in response to
property chain axiom: has input
definition: A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-12-26T19:45:49Z

disease arises from structure
type: ObjectProperty
sub property of: disease has basis in
range: connected anatomical structure
definition: A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2017-12-26T19:58:44Z

acts upstream of or within, positive effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, positive effect
imported from: OBO Relations Ontology
is positive form of: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:30Z

acts upstream of or within, negative effect
type: ObjectProperty
sub property of: acts upstream of or within
property chain axiom: enables
property chain axiom: causally upstream of or within, negative effect
imported from: OBO Relations Ontology
is negative form of: acts upstream of or within
created by: cjm
creation date: 2018-01-26T23:49:51Z

acts upstream of, positive effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, positive effect
property chain axiom: enables
property chain axiom: causally upstream of, positive effect
definition: c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive
imported from: OBO Relations Ontology
is positive form of: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:14Z

acts upstream of, negative effect
type: ObjectProperty
sub property of: acts upstream of
sub property of: acts upstream of or within, negative effect
property chain axiom: enables
property chain axiom: causally upstream of, negative effect
definition: c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative
imported from: OBO Relations Ontology
is negative form of: acts upstream of
created by: cjm
creation date: 2018-01-26T23:53:22Z

causally upstream of or within, negative effect
type: ObjectProperty
sub property of: causally upstream of or within
imported from: OBO Relations Ontology
is negative form of: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:05Z

causally upstream of or within, positive effect
type: ObjectProperty
sub property of: causally upstream of or within
imported from: OBO Relations Ontology
is positive form of: causally upstream of or within
created by: cjm
creation date: 2018-03-13T23:55:19Z

realized in response to
type: ObjectProperty
sub property of: causally related to
domain: realizable entity
range: process
property chain axiom: realized in
property chain axiom: causally downstream of
example of usage: A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions.
example of usage: An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut)
example of usage: Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph.
definition: r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r.
imported from: OBO Relations Ontology
contributor: Austin Meier
contributor: Chris Mungall
contributor: David Osumi-Sutherland
contributor: Marie Angelique Laporte
has_exact_synonym: triggered by process

regulates activity of
type: ObjectProperty
sub property of: causally influences
domain: material entity
range: material entity
definition: The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

regulates quantity of
type: ObjectProperty
sub property of: causally influences
domain: material entity
range: material entity
definition: The entity A has an activity that regulates the quantity or abundance or concentration of the entity B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly regulates activity of
type: ObjectProperty
sub property of: regulates activity of
domain: material entity
range: material entity
definition: The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

decreases by repression quantity of
type: ObjectProperty
sub property of: indirectly negatively regulates quantity of
domain: material entity
range: material entity
definition: The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

increases by expression quantity of
type: ObjectProperty
sub property of: indirectly positively regulates quantity of
domain: material entity
range: material entity
definition: The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

directly positively regulates quantity of
type: ObjectProperty
sub property of: directly regulates quantity of
domain: material entity
range: material entity
definition: The entity A has an activity that directly positively regulates the quantity of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

directly negatively regulates quantity of
type: ObjectProperty
sub property of: directly regulates quantity of
domain: material entity
range: material entity
definition: The entity A has an activity that directly negatively regulates the quantity of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly positively regulates activity of
type: ObjectProperty
sub property of: indirectly regulates activity of
domain: material entity
range: material entity
definition: The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B.
definition editor: Vasundra Touré
alternative term: indirectly activates
imported from: OBO Relations Ontology

destabilizes quantity of
type: ObjectProperty
sub property of: directly negatively regulates quantity of
domain: material entity
range: material entity
example of usage: AKT1 destabilizes quantity of FOXO (interaction from Signor database: SIGNOR-252844)
definition: An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

stabilizes quantity of
type: ObjectProperty
sub property of: directly positively regulates quantity of
domain: material entity
range: material entity
example of usage: AKT1 stabilizes quantity of XIAP (interaction from Signor database: SIGNOR-119488)
definition: An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly negatively regulates activity of
type: ObjectProperty
sub property of: indirectly regulates activity of
definition: The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B.
definition editor: Vasundra Touré
alternative term: indirectly inhibits
imported from: OBO Relations Ontology

directly regulates quantity of
type: ObjectProperty
sub property of: regulates quantity of
definition: The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly regulates quantity of
type: ObjectProperty
sub property of: regulates quantity of
definition: The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly negatively regulates quantity of
type: ObjectProperty
sub property of: indirectly regulates quantity of
definition: The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

indirectly positively regulates quantity of
type: ObjectProperty
sub property of: indirectly regulates quantity of
definition: The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B.
definition editor: Vasundra Touré
imported from: OBO Relations Ontology

disease relationship
type: ObjectProperty
definition: This relation groups relations between diseases and any other kind of entity.
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease.
imported from: OBO Relations Ontology
created by: cjm
creation date: 2018-09-26T00:00:32Z

has anatomical participant
type: ObjectProperty
sub property of: has participant
range: Class
  union of: material anatomical entity
  union of: immaterial anatomical entity
definition: p has anatomical participant c iff p has participant c, and c is an anatomical entity
imported from: OBO Relations Ontology
created by: cjm
creation date: 2018-09-26T01:08:58Z

in similarity relationship with
type: ObjectProperty
type: SymmetricProperty
definition: Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison.
editor note: TODO: Add homeomorphy axiom
imported from: OBO Relations Ontology
is homeomorphic for: continuant
is homeomorphic for: occurrent
creator: bgee.unil.ch
source: http://www.ncbi.nlm.nih.gov/pubmed/20116127
database_cross_reference: ECO:0000041
database_cross_reference: SO:similar_to
has_exact_synonym: sameness
has_exact_synonym: similar to
has_related_synonym: correspondence
has_related_synonym: resemblance

entity
type: Class
BFO OWL specification label: entity
BFO CLIF specification label: Entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: bfo.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

continuant
type: Class
subclass of: entity
subclass of: Restriction
  on property: part of
  all values from: continuant
subclass of: Restriction
  on property: has prototype
  all values from: continuant
subclass of: Restriction
  on property: in similarity relationship with
  all values from: continuant
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

occurrent
type: Class
subclass of: entity
subclass of: Restriction
  on property: part of
  all values from: occurrent
subclass of: Restriction
  on property: in similarity relationship with
  all values from: occurrent
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
definition: An entity that has temporal parts and that happens, unfolds or develops through time.
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

independent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: independent continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
imported from: bfo.owl
imported from: OBO Relations Ontology
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]

spatial region
type: Class
subclass of: immaterial entity
BFO OWL specification label: s-region
BFO CLIF specification label: SpatialRegion
editor note: BFO 2 Reference: Spatial regions do not participate in processes.
editor note: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
imported from: bfo.owl
elucidation: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has associated axiom(nl): All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has associated axiom(fol): (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has associated axiom(fol): (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]

temporal region
type: Class
subclass of: occurrent
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
imported from: bfo.owl
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

two-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 2d-s-region
BFO CLIF specification label: TwoDimensionalSpatialRegion
example of usage: an infinitely thin plane in space.
example of usage: the surface of a sphere-shaped part of space
imported from: bfo.owl
elucidation: A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
has associated axiom(fol): (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]

spatiotemporal region
type: Class
subclass of: occurrent
BFO OWL specification label: st-region
BFO CLIF specification label: SpatiotemporalRegion
example of usage: the spatiotemporal region occupied by a human life
example of usage: the spatiotemporal region occupied by a process of cellular meiosis.
example of usage: the spatiotemporal region occupied by the development of a cancer tumor
imported from: bfo.owl
elucidation: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
has associated axiom(nl): All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
has associated axiom(nl): Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
has associated axiom(nl): Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
has associated axiom(nl): Every spatiotemporal region occupies_spatiotemporal_region itself.
has associated axiom(nl): Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
has associated axiom(fol): (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
has associated axiom(fol): (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
has associated axiom(fol): (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]

process
type: Class
subclass of: occurrent
subclass of: Restriction
  on property: has prototype
  all values from: process
BFO OWL specification label: process
BFO CLIF specification label: Process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
imported from: bfo.owl
imported from: OBO Relations Ontology
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]

disposition
type: Class
subclass of: realizable entity
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

realizable entity
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: realizable entity
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

zero-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 0d-s-region
BFO CLIF specification label: ZeroDimensionalSpatialRegion
imported from: bfo.owl
elucidation: A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]

quality
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: quality
BFO OWL specification label: quality
BFO CLIF specification label: Quality
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]

specifically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: specifically dependent continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: bfo.owl
imported from: OBO Relations Ontology
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]

role
type: Class
subclass of: realizable entity
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

fiat object part
type: Class
subclass of: material entity
BFO OWL specification label: fiat-object-part
BFO CLIF specification label: FiatObjectPart
example of usage: or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
example of usage: the FMA:regional parts of an intact human body.
example of usage: the Western hemisphere of the Earth
example of usage: the division of the brain into regions
example of usage: the division of the planet into hemispheres
example of usage: the dorsal and ventral surfaces of the body
example of usage: the upper and lower lobes of the left lung
editor note: BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
imported from: bfo.owl
elucidation: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has associated axiom(fol): (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]

one-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 1d-s-region
BFO CLIF specification label: OneDimensionalSpatialRegion
example of usage: an edge of a cube-shaped portion of space.
imported from: bfo.owl
elucidation: A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]

three-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 3d-s-region
BFO CLIF specification label: ThreeDimensionalSpatialRegion
example of usage: a cube-shaped region of space
example of usage: a sphere-shaped region of space,
imported from: bfo.owl
elucidation: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
has associated axiom(fol): (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
imported from: bfo.owl
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

generically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: part of
  all values from: generically dependent continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
imported from: bfo.owl
imported from: OBO Relations Ontology
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]

function
type: Class
subclass of: disposition
BFO OWL specification label: function
BFO CLIF specification label: Function
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

one-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
imported from: bfo.owl
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
imported from: bfo.owl
imported from: OBO Relations Ontology
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]

continuant fiat boundary
type: Class
subclass of: immaterial entity
BFO OWL specification label: cf-boundary
BFO CLIF specification label: ContinuantFiatBoundary
definition: b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
editor note: BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions.
editor note: BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29
editor note: Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
imported from: bfo.owl
has associated axiom(nl): Every continuant fiat boundary is located at some spatial region at every time at which it exists
has associated axiom(fol): (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]

immaterial entity
type: Class
subclass of: independent continuant
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10
imported from: bfo.owl
imported from: OBO Relations Ontology

one-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
BFO OWL specification label: 1d-cf-boundary
BFO CLIF specification label: OneDimensionalContinuantFiatBoundary
example of usage: The Equator
example of usage: all geopolitical boundaries
example of usage: all lines of latitude and longitude
example of usage: the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin.
example of usage: the median sulcus of your tongue
imported from: bfo.owl
elucidation: a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
has associated axiom(fol): (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]

process profile
type: Class
subclass of: process
BFO OWL specification label: process-profile
BFO CLIF specification label: ProcessProfile
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
imported from: bfo.owl
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

relational quality
type: Class
subclass of: quality
BFO OWL specification label: r-quality
BFO CLIF specification label: RelationalQuality
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: a marriage bond, an instance of requited love, an obligation between one person and another.
definition: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
imported from: bfo.owl
has associated axiom(fol): (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]

two-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
BFO OWL specification label: 2d-cf-boundary
BFO CLIF specification label: TwoDimensionalContinuantFiatBoundary
imported from: bfo.owl
elucidation: a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
has associated axiom(fol): (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]

zero-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
BFO OWL specification label: 0d-cf-boundary
BFO CLIF specification label: ZeroDimensionalContinuantFiatBoundary
example of usage: the geographic North Pole
example of usage: the point of origin of some spatial coordinate system.
example of usage: the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet
editor note: zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
imported from: bfo.owl
elucidation: a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
has associated axiom(fol): (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]

zero-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 0d-t-region
BFO CLIF specification label: ZeroDimensionalTemporalRegion
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
imported from: bfo.owl
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

history
type: Class
subclass of: process
BFO OWL specification label: history
BFO CLIF specification label: History
imported from: bfo.owl
elucidation: A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])

anatomical entity
type: Class
subclass of: biological entity
imported from: caro.owl
imported from: OBO Relations Ontology

connected anatomical structure
type: Class
subclass of: material anatomical entity
imported from: caro.owl
imported from: OBO Relations Ontology

material anatomical entity
type: Class
subclass of: material entity
subclass of: anatomical entity
subclass of: Restriction
  on property: drains
  all values from: connected anatomical structure
imported from: caro.owl
imported from: OBO Relations Ontology

immaterial anatomical entity
type: Class
subclass of: immaterial entity
imported from: OBO Relations Ontology

biological entity
type: Class
subclass of: independent continuant
imported from: OBO Relations Ontology

biological_process
type: Class
subclass of: process
imported from: OBO Relations Ontology

disease process
type: Class
subclass of: pathological bodily process
definition: Disease process is the progression disease in an individual over time. The process begins with the appropriate exposure to or accumulation of factors sufficient for the disease process to begin in a susceptible host. For an infectious disease, the exposure is a microorganism. For cancer, the exposure may be a factor that initiates the process, such as asbestos fibers or components in tobacco smoke (for lung cancer), or one that promotes the process, such as estrogen (for endometrial cancer).
definition source: https://www.cdc.gov/ophss/csels/dsepd/ss1978/lesson1/section9.html
has_exact_synonym: disorder
label: 病程 @zh

ear or mastoid disease process
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: ear
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95
has icd10 code: H60-H95
has ICD10 name: Diseases of the ear and mastoid process
has ICD10 name: diseases of the ear or mastoid process
label: 耳或乳突疾病 @zh

atresia DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: atresia entity
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: atresia entity
label: 闭锁 @zh

infectious DP of external ear
type: Class
subclass of: infectious DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious
has ICD10 name: infectious diseases of external ear
label: 外耳感染性疾病 @zh

external ear DP
type: Class
equivalent class: Restriction
  on property: occurs in
  some values from: external ear
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: external ear
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H60-H62
has icd10 code: H60-H95
has ICD10 name: Diseases of external ear
label: 外耳疾病病程 @zh

ossification DP
type: Class
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: ossification entity
label: 骨化 @zh

cellulitis DP
type: Class
subclass of: inflammation DP
subclass of: Restriction
  on property: has DP output
  some values from: cellulitis anatomical entity
has ICD10 name: cellulitis
label: 蜂窝织炎病程 @zh

otitis externa DP
type: Class
equivalent class: Class
  intersection of: otitis DP
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
subclass of: external ear DP
subclass of: otitis DP
has gbt_14396 code: H60.900
has icd11 code: EG4Z
has icd10 code: H60
has ICD10 name: otitis externa
label: 外耳炎 @zh

infectious
type: Class
subclass of: morphology
label: 感染性 @zh

deformity DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: deformity entity
subclass of: pathological anatomical entity DP
definition: is a major abnormality in the shape of a body part or organ compared to the normal shape of that part.
label: 畸形

cholesteatoma DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: cholesteatoma entity
subclass of: pathological anatomical entity DP
label: 胆脂瘤 @zh

pinna fistula DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP output
    some values from: fistula
subclass of: fistula DP
has gbt_14396 code: H61.102
has ICD10 name: pinna fistula
label: 耳郭瘘 @zh

noninfectious inflammation of external ear DP
type: Class
subclass of: noninfectious inflammation DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: noninfectious
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
label: 外耳非感染性炎症病程 @zh

pathological anatomical entity DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: pathological anatomical entity
subclass of: disease process
subclass of: Restriction
  on property: has DP output
  some values from: pathological anatomical entity

cyst DP
type: Class
subclass of: pathological anatomical entity DP
definition: A disease process that has the outcome of the formation of a cyst
label: 囊肿 @zh

otitis anatomical entity
type: Class
subclass of: inflammatory anatomical entity
subclass of: Restriction
  on property: occurs in
  some values from: ear
definition: inflammatory anatomical entity that is located in ear @zh
label: 耳炎体 @zh

fistula DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: fistula
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: fistula
label: 瘘 @zh

granuloma DP
type: Class
subclass of: inflammation DP
subclass of: Restriction
  on property: has DP output
  some values from: granuloma
has ICD10 name: granuloma
label: 肉芽肿病程 @zh

noninflammatory DP
type: Class
subclass of: disease process
subclass of: Restriction
  on property: has DP material quality
  some values from: noninflammatory
has ICD10 name: noninflammatory disorders
label: 非炎症性疾病病程 @zh

tumor DP
type: Class
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: tumor
label: 肿物 @zh

scar DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: scar entity
subclass of: skin DP
label: 瘢痕病程 @zh

noninflammatory DP of the external ear
type: Class
subclass of: noninflammatory DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: noninflammatory
has ICD10 name: noninflammatory disorders of the external ear
label: 非炎症性外耳疾患 @zh

hernia DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: hernia
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: hernia
definition: A hernia occurs when an organ pushes through an opening in the muscle or tissue that holds it in place. For example, the intestines may break through a weakened area in the abdominal wall. Hernias are most common in the abdomen, but they can also appear in the upper thigh, belly button, and groin areas. Most hernias aren’t immediately life-threatening, but they don’t go away on their own. Sometimes they can require surgery to prevent potentially dangerous complications.
definition source: https://www.healthline.com/health/hernia
label: 疝 @zh

obstructive
type: Class
subclass of: structure
label: 阻塞性 @zh

otitis DP
type: Class
subclass of: inflammation DP
subclass of: Restriction
  on property: occurs in
  some values from: ear
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
label: 耳炎病程 @zh

stenosis DP
type: Class
subclass of: pathological anatomical entity DP
label: 狭窄 @zh

pseudocyst DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: pseudocyst
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: pseudocyst
label: 假性囊肿 @zh

infectious DP
type: Class
subclass of: immune system DP
has ICD10 name: infectious disease
has_exact_synonym: 感染 @zh
label: 感染性疾病过程 @zh

immune system DP
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: immune system
label: 免疫系统疾病过程 @zh

acquired
type: Class
subclass of: physical quality of a process
definition: developed after birth : not congenital or hereditary
definition source: https://www.merriam-webster.com/dictionary/acquired
has_exact_synonym: 获得性 @zh
label: 后天性 @zh

other
type: Class
subclass of: relational quality
label: 其他的 @zh

specified
type: Class
subclass of: relational quality
label: 特指的 @zh

unspecified
type: Class
subclass of: relational quality
label: 非特指的 @zh

diseases claasified elsewhere
type: Class
subclass of: relational quality
label: 可分类于他处的疾病 @zh

necrotic otitis externa LHPM
type: Class
subclass of: otitis externa DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
label: 坏死性外耳炎 LHPM @zh

syndrome DP
type: Class
subclass of: disease process

inflammation DP
type: Class
subclass of: immune system DP
definition: an immune system disease process that undergoes an inflammation process and has output of an inflammatory anatomical entity.
definition source: https://www.webmd.com/arthritis/about-inflammation
has_exact_synonym: 炎 @zh
label: 炎症病程 @zh

Aspergillus
type: Class
subclass of: fungus
label: 曲霉菌 @zh

Candida
type: Class
subclass of: fungus
label: 念珠菌 @zh

chemical
type: Class
subclass of: morphology
label: 化学性 @zh

necrosis DP
type: Class
subclass of: pathological anatomical entity DP
label: 坏死 @zh

severe necrosis DP
type: Class
subclass of: necrosis DP
label: 严重坏死 @zh

diffuse
type: Class
subclass of: physical quality of a process
subclass of: Restriction
  on property: has DP material quality
  some values from: diffuse
label: 弥漫性 @zh

hemorrhagic
type: Class
subclass of: morphology
label: 出血性 @zh

water
type: Class
subclass of: environment entity
label: 水 @zh

fungus
type: Class
subclass of: material anatomical entity
label: 真菌 @zh

perichondritis DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: perichondritis anatomical entity
subclass of: otitis DP
subclass of: Restriction
  on property: has DP output
  some values from: perichondritis anatomical entity
definition: Perichondritis is inflammation of the perichondrium, a layer of connective tissue which surrounds cartilage
definition editor: Oliver He, Eric Wan
definition source: https://en.wikipedia.org/wiki/Perichondritis
definition source: https://www.icd10data.com/ICD10CM/Index/P/Perichondritis
label: 软骨膜炎 @zh

chondrodermatitis DP
type: Class
subclass of: dermatitis DP
subclass of: Restriction
  on property: occurs in
  some values from: cartilage tissue
subclass of: Restriction
  on property: has DP output
  some values from: dermatitis anatomical entity
has ICD10 name: chondrodermatitis
label: 软骨皮炎 @zh

nodularis
type: Class
subclass of: morphology
label: 结节性 @zh

noninfectious
type: Class
subclass of: morphology
label: 非感染性 @zh

skin DP
type: Class
subclass of: disorders of the skin and subcutaneous tissue
subclass of: Restriction
  on property: occurs in
  some values from: zone of skin
has ICD10 name: skin disease
label: 皮肤疾病 @zh

abscess DP
type: Class
subclass of: infectious DP
subclass of: inflammation DP
subclass of: Restriction
  on property: has DP output
  some values from: abscess
has_related_synonym: 疖 @zh
label: 脓肿病程 @zh

seborrhoeic
type: Class
subclass of: morphology
label: 脂溢性 @zh

noninflammatory
type: Class
subclass of: morphology
label: 非炎症性 @zh

cauliflower like
type: Class
subclass of: physical quality of a process
label: 菜花样的 @zh

environment entity
type: Class
subclass of: Etiology Entity
label: 环境因素 @zh

keloid DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: keloid entity
subclass of: scar DP
label: 瘢痕瘤病程 @zh

exostosis DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: exostosis
subclass of: pathological anatomical entity DP
subclass of: Restriction
  on property: has DP output
  some values from: exostosis
has_exact_synonym: 骨疣
label: 外生骨疣 @zh

disease (process) of the circulatory system
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: circulatory system
alternative term: disease of the circulatory system
has icd10 code: I00-I99
has ICD10 name: Diseases of the circulatory system

hypertensive disease process
type: Class
subclass of: hypertensive diseases (NEW)
definition source: https://en.wikipedia.org/wiki/Hypertension
has icd10 code: I10-I15.9
has ICD10 name: Hypertensive diseases

hematoma
type: Class
subclass of: morphology
label: 血肿 @zh

keratosis DP
type: Class
subclass of: skin DP
subclass of: Restriction
  on property: has DP output
  some values from: keratosis entity
has_exact_synonym: 角化病
has_exact_synonym: 角化症 @zh
label: 角化病程 @zh

cyst
type: Class
subclass of: pathological anatomical entity
definition: is a closed sac, having a distinct membrane and division compared with the nearby tissue. Hence, it is a cluster of cells that has grouped together to form a sac (not unlike the manner in which water molecules group together, forming a bubble); however, the distinguishing aspect of a cyst is that the cells forming the "shell" of such a sac are distinctly abnormal (in both appearance and behaviour) when compared with all surrounding cells for that given location. It may contain air, fluids, or semi-solid material. A collection of pus is called an abscess, not a cyst. Once formed, sometimes a cyst may resolve on its own. When a cyst fails to resolve, it may need to be removed surgically, but that would depend upon its type and location.
label: 囊肿 @zh

actinic
type: Class
subclass of: morphology
label: 光化性 @zh

impacted
type: Class
subclass of: morphology
label: 栓塞性的 @zh

chemical entity
type: Class
subclass of: environment entity
label: 化学物质 @zh

infectious via bacterium
type: Class
subclass of: infectious
definition: bacterial
label: 细菌性 @zh

parasitic
type: Class
subclass of: morphology
label: 寄生性 @zh

viral
type: Class
subclass of: morphology
label: 病毒性 @zh

unspecified secondary hypertension DP
type: Class
subclass of: secondary hypertension DP
definition: I15.9 is a billable ICD code used to specify a diagnosis of secondary hypertension, unspecified. A 'billable code' is detailed enough to be used to specify a medical diagnosis.
definition editor: Virginia He, Oliver He
definition source: https://icd.codes/icd10cm/I159#:~:text=a%20principal%20diagnosis.-,I15.,diagnosis%20of%20secondary%20hypertension%2C%20unspecified.
has icd10 code: I15.9
code billability: Non-Billable
has ICD10 name: Secondary hypertension, unspecified

essential primary hypertension DP
type: Class
subclass of: hypertensive disease process
subclass of: Restriction
  on property: has process profile
  some values from: primary disease profile
definition: A hypertensive disease that shows up with persistently elevated high blood pressure in the arteries, and has no identifiable cause. It does not include those hypertensive diseases complicating pregnancy, childbirth and the puerperium. Note that the essential hypertension affects 95% of hypertensive patients.
definition editor: Justin Song, Oliver He, Virginia He
alternative term: essential hypertension
alternative term: primary hypertension
definition source: https://en.wikipedia.org/wiki/Essential_hypertension
definition source: https://www.healthline.com/health/essential-hypertension
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I10-/I10
definition source: https://www.unboundmedicine.com/icd/view/ICD-10-CM/895449/all/I10___Essential__primary__hypertension
has icd10 code: I10
code billability: Billable
has ICD10 name: Essential (primary) hypertension

eczematoid
type: Class
subclass of: morphology
label: 湿疹样 @zh

pathological anatomical entity
type: Class
subclass of: anatomical entity
definition: is a pathological anatomical structures transformed from pathological continuant entities.
definition source: On carcinomas and other pathological entities ,Comp Funct Genomics. 2005;6(7-8):379-87. doi: 10.1002/cfg.497.. https://www.ncbi.nlm.nih.gov/pubmed/18629199

erysipelas DP
type: Class
subclass of: skin DP
subclass of: Restriction
  on property: occurs in
  some values from: zone of skin
label: 丹毒病程 @zh

hernia
type: Class
subclass of: pathological anatomical entity
definition: is the abnormal exit of tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides.[1] Hernias come in a number of different types.[6] Most commonly they involve the abdomen, specifically the groin.[6] Groin hernias are most common of the inguinal type but may also be femoral.[1] Other hernias include hiatus, incisional, and umbilical hernias.[6] Symptoms are present in about 66% of people with groin hernias.[1] This may include pain or discomfort especially with coughing, exercise, or going to the bathroom.[1] Often it gets worse throughout the day and improves when lying down.[1] A bulging area may occur that becomes larger when bearing down.[1] Groin hernias occur more often on the right than left side.[1] The main concern is strangulation, where the blood supply to part of the bowel is blocked.[1] This usually produces severe pain and tenderness of the area.[1] Hiatus or hiatal hernias often result in heartburn but may also cause chest pain or pain with eating.[ @zh
label: 疝 @zh

necrotic
type: Class
subclass of: morphology
definition: is a form of cell injury which results in the premature death of cells in living tissue by autolysis.
definition source: https://en.wikipedia.org/wiki/Necrosis
label: 坏死性 @zh

pinna defect after burn PKPM
type: Class
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: pinna
subclass of: Restriction
  on property: has DP material quality
  some values from: acquired
subclass of: Restriction
  on property: has DP output
  some values from: deformity entity
label: 烧伤后耳廓缺损 PKPM @zh

cauliflower ear
type: Class
subclass of: deformity entity
definition: is an irreversible condition that occurs when the external portion of the ear is hit and develops a blood clot or other collection of fluid under the perichondrium. This separates the cartilage from the overlying perichondrium that supplies its nutrients, causing it to die and resulting in the formation of fibrous tissue in the overlying skin. As a result, the outer ear becomes permanently swollen and deformed, resembling a cauliflower.
label: 菜花耳 @zh

deformity entity
type: Class
subclass of: pathological anatomical entity
definition: abnormality in the shape of a body part or organ
has_exact_synonym: defect
has_exact_synonym: 畸形
has_exact_synonym: 缺损 @zh
label: 畸形体 @zh

Obsolete class
type: Class
subclass of: entity

noninfectious inflammation DP
type: Class
subclass of: inflammation DP
subclass of: Restriction
  on property: has DP material quality
  some values from: noninfectious
label: 非感染性炎症病程 @zh

sunlight
type: Class
subclass of: environment entity
label: 日光 @zh
label: 阳光 @zh

mycotic
type: Class
subclass of: morphology
label: 真菌性 @zh

dermatitis DP
type: Class
equivalent class: Restriction
  on property: occurs in
  some values from: zone of skin
equivalent class: Restriction
  on property: has DP output
  some values from: dermatitis anatomical entity
subclass of: inflammation DP
subclass of: Restriction
  on property: occurs in
  some values from: zone of skin
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
has ICD10 name: dermatitis
label: 皮炎病程 @zh

acquired from gun shoot
type: Class
subclass of: acquired from injury
has_exact_synonym: 枪伤 @zh
label: 枪伤后 @zh

defect
type: Class
subclass of: deformity entity
label: 缺损 @zh

cholesteatoma entity
type: Class
subclass of: pathological anatomical entity
definition: is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and/or mastoid process. Cholesteatomas are not cancerous as the name may suggest, but can cause significant problems because of their erosive and expansile properties. This can result in the destruction of the bones of the middle ear (ossicles), as well as growth through the base of the skull into the brain. They often become infected and can result in chronically draining ears. Treatment almost always consists of surgical removal.
label: 胆脂瘤体 @zh

scar entity
type: Class
subclass of: pathological anatomical entity
definition: is an area of fibrous tissue that replaces normal skin after an injury. Scars result from the biological process of wound repair in the skin, as well as in other organs and tissues of the body. Thus, scarring is a natural part of the healing process. With the exception of very minor lesions, every wound (e.g., after accident, disease, or surgery) results in some degree of scarring. An exception to this are animals with complete regeneration, which regrow tissue without scar formation.
has_exact_synonym: 瘢痕
label: 瘢痕体 @zh

keloid entity
type: Class
subclass of: scar entity
definition: Keloid, also known as keloid disorder and keloidal scar,[1] is the formation of a type of scar which, depending on its maturity, is composed mainly of either type III (early) or type I (late) collagen. It is a result of an overgrowth of granulation tissue (collagen type 3) at the site of a healed skin injury which is then slowly replaced by collagen type 1. Keloids are firm, rubbery lesions or shiny, fibrous nodules, and can vary from pink to the color of the person's skin or red to dark brown in color. A keloid scar is benign and not contagious, but sometimes accompanied by severe itchiness, pain,[2] and changes in texture. In severe cases, it can affect movement of skin. Keloid scars are seen 15 times more frequently in people of sub-Saharan African descent than in people of European descent. @zh
label: 瘢痕瘤体 @zh

granuloma
type: Class
subclass of: pathological anatomical entity
definition: is a structure formed during inflammation that is found in many diseases. It is a collection of immune cells known as macrophages.[1] Granulomas form when the immune system attempts to wall off substances it perceives as foreign but is unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as keratin and suture fragments. @zh
has_exact_synonym: 肉芽肿
label: 肉芽肿体 @zh

TEST: cellulitis of external ear
type: Class
equivalent class: Restriction
  on property: occurs in
  some values from: external ear
equivalent class: Restriction
  on property: has DP output
  some values from: cellulitis anatomical entity
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP output
  some values from: cellulitis anatomical entity
label: 外耳蜂窝织炎 TSEM @zh

malignant essential hypertension DP
type: Class
subclass of: essential primary hypertension DP
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition source: http://www.icd9data.com/2015/Volume1/390-459/401-405/401/401.0.htm
definition source: https://www.webmd.com/hypertension-high-blood-pressure/guide/what-is-malignant-hypertension#1
has icd9 code: 401.0
comment: This term exists in ICD-9 but not ICD-10

fistula
type: Class
subclass of: pathological anatomical entity
definition: is an abnormal connection between two hollow spaces (technically, two epithelialized surfaces), such as blood vessels, intestines, or other hollow organs. Fistulas are usually caused by injury or surgery, but they can also result from an infection or inflammation.[3] Fistulas are generally a disease condition, but they may be surgically created for therapeutic reasons.
label: 瘘 @zh

pseudocyst
type: Class
subclass of: pathological anatomical entity
definition: Pseudocysts are like cysts, but lack epithelial or endothelial cells. Initial management consists of general supportive care. Symptoms and complications caused by pseudocysts require surgery. Computed tomography (CT) scans are used for initial imaging of cysts, and endoscopic ultrasounds are used in differentiating between cysts and pseudocysts. Endoscopic drainage is a popular and effective method of treating pseudocysts. This is not to be confused with the so-called "pseudocystic appearance", mainly radiographically, of other lesions, such as Stafne static bone cyst and aneurysmal bone cyst[1] of the jaws. @zh
label: 假性囊肿 @zh

tumor
type: Class
subclass of: pathological anatomical entity
definition: is a type of abnormal and excessive growth, called neoplasia, of tissue. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and it persists growing abnormally, even if the original trigger is removed.[1][2][3] This abnormal growth usually (but not always) forms a mass.[4] When it forms a mass, it may be called a tumor.
has_exact_synonym: neoplasm
label: 肿物 @zh

inflammatory
type: Class
subclass of: morphology
label: 炎症性 @zh

keratosis entity
type: Class
subclass of: pathological anatomical entity
definition: is a growth of keratin on the skin or on mucous membranes stemming from keratinocytes, the prominent cell type in the epidermis. @zh
definition source: https://en.wikipedia.org/wiki/Keratosis
has_related_synonym: 角质化体 @zh
label: 角化体 @zh

atresia entity
type: Class
subclass of: pathological anatomical entity
definition: is a condition in which an orifice or passage in the body is (usually abnormally) closed or absent. Examples of atresia include: Biliary atresia, a condition in newborns in which the common bile duct between the liver and the small intestine is blocked or absent.
definition source: https://en.wikipedia.org/wiki/Atresia
has_exact_synonym: 闭锁
label: 闭锁体 @zh

exostosis
type: Class
subclass of: pathological anatomical entity
definition: An exostosis, also known as bone spur, is the formation of new bone on the surface of a bone.[1] Exostoses can cause chronic pain ranging from mild to debilitatingly severe, depending on the shape, size, and location of the lesion. It is most commonly found in places like the ribs, where small bone growths form, but sometimes larger growths can grow on places like the ankles, knees, shoulders, elbows and hips. Very rarely are they on the skull.
has_exact_synonym: 骨疣
label: 外生骨疣 @zh

benign essential hypertension DP
type: Class
subclass of: essential primary hypertension DP
subclass of: Restriction
  on property: has process profile
  some values from: belign disease profile
has icd9 code: 401.1
comment: This term exists in ICD-9 but not ICD-10

cellulitis anatomical entity
type: Class
subclass of: inflammatory anatomical entity
definition: inflammatory anatomical entity that is located in a cellulite
label: 蜂窝织炎体 @zh

stenosis
type: Class
subclass of: pathological anatomical entity
definition: abnormal narrowed structure or organ
has_exact_synonym: 狭窄
label: 狭窄体 @zh

erysipelas
type: Class
subclass of: pathological anatomical entity
definition: is an acute infection typically with a skin rash, usually on any of the legs and toes, face, arms, and fingers.[1] It is an infection of the upper dermis and superficial lymphatics, usually caused by beta-hemolytic group A Streptococcus bacteria on scratches or otherwise infected areas.[2] Erysipelas is more superficial than cellulitis, and is typically more raised and demarcated.[1] The term is from Greek ἐρυσίπελας, meaning "red skin".
label: 丹毒 @zh

abscess of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: abscess
subclass of: otitis externa DP
subclass of: abscess DP
has gbt_14396 code: H60.000
has icd11 code: AA00
has icd10 code: H60.0
has ICD10 name: abscess of external ear
has_related_synonym: 疖 @zh
has_related_synonym: 痈 @zh
label: 外耳脓肿病程 @zh

ossification entity
type: Class
subclass of: pathological anatomical entity
definition: bony substance
label: 骨化体 @zh

inflammatory anatomical entity
type: Class
subclass of: pathological anatomical entity
definition: a physical pathological anatomic entity that is a result of an inflammation process
definition editor: Eric Wan, Oliver He
has_broad_synonym: 感染
has_broad_synonym: 炎
has_broad_synonym: 炎症
has_exact_synonym: 炎症体 @zh
label: 发炎体 @zh

abscess
type: Class
subclass of: pathological anatomical entity
definition: is a collection of pus that has built up within the tissue of the body.[1] Signs and symptoms of abscesses include redness, pain, warmth, and swelling.[1] The swelling may feel fluid-filled when pressed.[1] The area of redness often extends beyond the swelling.[6] Carbuncles and boils are types of abscess that often involve hair follicles, with carbuncles being larger.
definition source: https://en.wikipedia.org/wiki/Abscess
label: 脓肿 @zh

carbuncle
type: Class
subclass of: abscess
definition: is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus aureus or Streptococcus pyogenes.[1] The presence of a carbuncle is a sign that the immune system is active and fighting the infection.[2] The infection is contagious and may spread to other areas of the body, or other people; those living in the same residence may develop carbuncles at the same time.[3] In the early 21st century, infection involving methicillin-resistant staphylococcus aureus (MRSA) has become more common.
definition source: https://en.wikipedia.org/wiki/Carbuncle
label: 痈 @zh

furuncle
type: Class
subclass of: abscess
definition: is a deep folliculitis, infection of the hair follicle. It is most commonly caused by infection by the bacterium Staphylococcus aureus, resulting in a painful swollen area on the skin caused by an accumulation of pus and dead tissue.[1] Boils which are expanded are basically pus-filled nodules.[2][verification needed] Individual boils clustered together are called carbuncles.[3] Most human infections are caused by coagulase-positive S. aureus strains, notable for the bacteria's ability to produce coagulase, an enzyme that can clot blood. Almost any organ system can be infected by S. aureus.
has_exact_synonym: boil
label: 疖 @zh

mycosis DP
type: Class
subclass of: infectious DP of external ear
subclass of: Restriction
  on property: caused by
  some values from: fungus
has ICD10 name: mycosis
label: 真菌病 @zh

necrosis entity
type: Class
subclass of: pathological anatomical entity
definition: a necrotic object
label: 坏死体 @zh

external acoustic meatus atresia after burn JYPM
type: Class
subclass of: external ear DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP material quality
  some values from: acquired from burn
subclass of: Restriction
  on property: has DP output
  some values from: atresia entity
label: 烧伤后外耳道闭锁 JYPM @zh

TEST: cholesteatoma of external auditory canal
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP output
  some values from: cholesteatoma entity
label: 外耳道胆脂瘤 @zh

chondrodermatitis anatomical entity
type: Class
subclass of: inflammatory anatomical entity
definition: inflammatory anatomical entity that is located in the skin of a cartilage tissue
label: 软骨皮炎体 @zh

perichondritis anatomical entity
type: Class
subclass of: inflammatory anatomical entity
definition: inflammatiory anatomical entity in the membrane of cartilage tissue
label: 软骨膜炎体 @zh

acquired from injury
type: Class
subclass of: acquired
label: 因外伤导致的 @zh

acquired from burn
type: Class
subclass of: acquired from injury
has_exact_synonym: after burn
has_exact_synonym: 烧伤后
label: 烧伤所致 @zh

acquired from knife
type: Class
subclass of: acquired from injury
has_exact_synonym: 砍伤后 @zh
label: 刀伤后 @zh

infectious disorder in pinna PKDM
type: Class
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: pinna
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
label: 耳廓感染 PKDM @zh

dermis and subcutaneous tissues
type: Class
subclass of: tissue
label: 皮及皮下组织 @zh

external ear furuncle PKPM
type: Class
subclass of: external ear DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP output
  some values from: furuncle
label: 外耳道疖 PKPM @zh

dermatitis anatomical entity
type: Class
subclass of: inflammatory anatomical entity
subclass of: Restriction
  on property: occurs in
  some values from: zone of skin
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
definition: inflammatory anatomical entity that is located in skin
label: 皮炎体 @zh

granuloma in pinna PKPM
type: Class
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: pinna
subclass of: Restriction
  on property: has DP output
  some values from: granuloma
label: 耳廓肉芽肿 PKPM @zh

external ear carbuncle DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: carbuncle
subclass of: abscess of external ear DP
has gbt_14396 code: H60.002
has ICD10 name: external ear carbuncle
label: 外耳痈病程 @zh

external ear furuncle DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: furuncle
subclass of: abscess of external ear DP
has gbt_14396 code: H60.001
has ICD10 name: external ear furuncle
label: 外耳疖病程 @zh

infectious via virus
type: Class
subclass of: infectious

malignant disease profile
type: Class
subclass of: disease profile

belign disease profile
type: Class
subclass of: disease profile

secondary hypertension DP
type: Class
subclass of: hypertensive disease process
subclass of: Restriction
  on property: has process profile
  some values from: secondary disease profile
definition: A hypertensive disease that is caused by an identifiable underlying primary cause
alternative term: inessential hypertension
definition source: https://en.wikipedia.org/wiki/Secondary_hypertension
definition source: https://www.unboundmedicine.com/icd/view/ICD-10-CM/864037/all/I15___Secondary_hypertension
has icd10 code: I15
code billability: Non-Billable
has ICD10 name: Secondary hypertension

disease (process) in the respiratory system
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: respiratory system
has icd10 code: J00-J99
has ICD10 name: Diseases of the respiratory system

pneumonia due to pathogen
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: occurs in
  some values from: lung
has icd10 code: J09-J18
has ICD10 name: Influenza and pneumonia

viral pneumonia
type: Class
subclass of: pneumonia due to pathogen
subclass of: Restriction
  on property: has quality
  some values from: viral
definition: Inflammation of the lung that is caused by viral infection; causes air sacs in lungs to fill up with fluid.
definition editor: Virginia He
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J12.9
code billability: Billable
has ICD10 name: Viral pneumonia, unspecified

influenza pneumonia
type: Class
subclass of: viral pneumonia

bacterial pneumonia
type: Class
subclass of: pneumonia due to pathogen
subclass of: Restriction
  on property: has quality
  some values from: bacterial
definition: an infection of your lungs caused by certain bacteria.
definition editor: Virginia He
definition source: https://www.webmd.com/lung/bacterial-pneumonia#:~:text=Bacterial%20pneumonia%20is%20an%20infection,throat%20without%20causing%20any%20trouble.
has icd10 code: J15
code billability: Non-billable
has ICD10 name: Bacterial pneumonia, not elsewhere classified

pneumonia due to Streptococcus pneumoniae
type: Class
subclass of: bacterial pneumonia
definition: an infection that inflames the air sacs in one or both lungs. Caused by Streptococcus pneumoniae bacteria
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204
has icd10 code: J13
code billability: Billable
has ICD10 name: Pneumonia due to Streptococcus pneumoniae

COVID-19 pneumonia
type: Class
subclass of: viral pneumonia
has icd10 code: U07.1
code billability: Billable
has ICD10 name: COVID-19, virus identified

COVID-19, virus not identified
type: Class
subclass of: viral pneumonia
definition: a mild to severe respiratory illness that is caused by a coronavirus
definition editor: Oliver He, Virginia He
definition source: https://www.merriam-webster.com/dictionary/COVID-19
definition source: https://www.who.int/classifications/icd/COVID-19-coding-icd10.pdf
has icd10 code: U07.2
has ICD10 name: COVID-19, virus not identified

clinically-epidemiologically diagnosied COVID-19
type: Class
subclass of: COVID-19, virus not identified

postprocedural hypertension DP
type: Class
subclass of: disease (process) of the circulatory system
definition: high blood pressure after a surgical procedure
definition editor: Virginia He, Oliver He
definition source: https://en.wikipedia.org/wiki/Hypertension
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.3
has icd10 code: I97.3
code billability: Billable
has ICD10 name: postprocedural hypertension

disease primary
type: Class
subclass of: physical quality of a process
definition: developed after birth : not congenital or hereditary

primary disease profile
type: Class
subclass of: disease profile
definition: A disease profile that does not have a known secondary cause
definition editor: Virginia He, Oliver He
alternative term: essential disease profile

secondary disease profile
type: Class
subclass of: disease profile
definition: A disease profile that is caused by another medical condition
definition editor: Virginia He, Oliver He

disease profile
type: Class
subclass of: process profile
alternative term: disease process profile

acute disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

chronic disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

influenza due to unidentified influenza virus with pneumonia
type: Class
subclass of: influenza pneumonia
definition: a common sickness combined with a lung infection caused by an unspecified pathogen.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.0
has icd10 code: J11.0
code billability: Non-billable
has ICD10 name: Influenza due to unidentified influenza virus with pneumonia

pneumonia due to SARS-associated coronavirus
type: Class
subclass of: viral pneumonia
definition: pneumonia attacks the respiratory system caused by SARS-CoV-2
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J12.81
code billability: Billable
has ICD10 name: Pneumonia due to SARS-associated coronavirus

hypertensive heart disease process without heart failure
type: Class
subclass of: essential primary hypertension DP
definition: Heart conditions caused by high blood pressure
definition editor: Virginia He
definition source: https://www.healthline.com/health/hypertensive-heart-disease#:~:text=Hypertensive%20heart%20disease%20refers%20to,artery%20disease%2C%20and%20other%20conditions
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I11-/I11.9
has icd10 code: I11.9
code billability: Billable
has ICD10 name: Hypertensive heart disease without heart failure

other viral pneumonia
type: Class
subclass of: viral pneumonia
definition: pneumonia attacks the respiratory system. Contagious and hard to treat.
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J12.8
code billability: Non-billable
has ICD10 name: other viral pneumonia

influenza due to pathogen
type: Class
subclass of: influeza and pneumonia (NEW)
has icd10 code: J09-J18
has ICD10 name: Influenza and pneumonia

ischemic heart DP
type: Class
subclass of: disease (process) of the circulatory system
subclass of: Restriction
  on property: has process profile
  some values from: ischemic disease profile
definition: Also called coronary artery disease, describes heart problems caused by narrowed arteries that supply blood to the heart.
definition source: https://www.google.com/search
has icd10 code: I20-I25
has ICD10 name: Ischemic heart diseases

influenza due other identified influenza virus with pneumonia
type: Class
subclass of: influenza pneumonia
definition: a highly contagious viral infection of the respiratory passages causing fever and severe aching, often occuring in epidemics.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes
has icd10 code: J10.0
code billability: Non-billable
has ICD10 name: Influenza due to other identified influenza virus with pneumonia

renal tubulo-interstitial disease processes
type: Class
subclass of: disease (process) of the genitourinary system
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: acute or chronic inflammation of the renal tubules and interstitium. Acute interstitial nephritis is commonly caused by allergic reactions to drugs, but infection or systemic disease may also precipitate the disease.
definition editor: Virginia He, Justin Song
definition source: https://www.amboss.com/us/knowledge/Tubulointerstitial_diseases#:~:text=Tubulointerstitial%20diseases%20are%20characterized%20by,may%20also%20precipitate%20the%20disease.
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16
has icd10 code: N10-N16
has ICD10 name: Renal tubulo-interstitial diseases

Influenza due to unidentified influenza virus with other manisfestations
type: Class
subclass of: influenza due to pathogen
definition: A common viral infection that can be deadly, especially in high-risk groups.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.1
has icd10 code: J11.1
code billability: Billable
has ICD10 name: Influenza due to unidentified influenza virus with other respiratory manisfestations

chronic ischemic heart DP
type: Class
subclass of: ischemic heart DP
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: heart problems caused by narrowed heart arteries. When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to heart attack.
definition editor: Virginia He
definition source: https://www.ncbi.nlm.nih.gov/books/NBK209964/
has icd10 code: I25
code billability: Non-billable
has ICD10 name: Chronic ischemic heart disease

atherosclerotic heart DP of native coronary artery
type: Class
subclass of: chronic ischemic heart DP
subclass of: Restriction
  on property: has process profile
  some values from: atherosclerotic disease profile
definition: heart problems caused by narrowed heart arteries. When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to heart attack.
definition editor: Virginia He, Justin Song
definition source: https://www.ncbi.nlm.nih.gov/books/NBK209964/
has icd10 code: I25.1
code billability: Non-billable
has ICD10 name: Atherosclerotic heart disease of native coronary artery

ischemic disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

Influenza due to unidentified influenza virus with other respiratory manisfestations
type: Class
subclass of: Influenza due to unidentified influenza virus with other manisfestations
definition: A highly contagious, common viral infection of the respiratory passages causing fever and severe aching
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.8
has icd10 code: J11.8
code billability: Non-billable
has ICD10 name: Influenza due to unidentified influenza virus with other respiratory manisfestations

pneumonia due to staphylococcus
type: Class
subclass of: bacterial pneumonia
definition: lung inflammation caused by bacterial infection, in which air sacs fill with pus
definition editor: Virginia He
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J15.2
code billability: Non-billable
has ICD10 name: Pneumonia due to staphylococcus

atherosclerotic disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

acute nasopharyngitis (common cold)
type: Class
subclass of: acute upper respiratory infections
definition: An inflammatory attack of the pharynx and nassal cavities. Minor and is a common contagious throat disease.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J00-/J00
has icd10 code: J00
code billability: Billable
has ICD10 name: Acute nasopharyngitis [common cold]

acute pharyngitis, unspecified
type: Class
subclass of: acute upper respiratory infections
definition: Inflammation of the pharynx, which is in the back of the throat. Commonly referred to as "sore throat"
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J02-/J02.9
has icd10 code: J02.9
code billability: Billable
has ICD10 name: Acute pharyngitis, unspecified

acute upper respiratory infection, unspecified
type: Class
subclass of: acute upper respiratory infections
definition: upper respiratory system is infected and parts will become inflamed or damaged.
definition editor: Virginia He
definition source: https://www.healthline.com/health/acute-upper-respiratory-infection#What-is-acute-upper-respiratory-infection?
has icd10 code: J06.9
code billability: Billable
has ICD10 name: Acute upper respiratory infection, unspecified

pneumonia due to other aerobic gram-negative bacteria
type: Class
subclass of: bacterial pneumonia
definition: pneumonia caused by bacteria
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J15.6
code billability: Billable
has ICD10 name: Pneumonia due to other aerobic Gram-negative bacteria

pneumonia due to other specified bacteria
type: Class
subclass of: bacterial pneumonia
definition: pneumonia caused by bacteria
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J15.8
code billability: Billable
has ICD10 name: Pneumonia due to other specified bacteria

unspecified bacterial pneumonia
type: Class
subclass of: bacterial pneumonia
definition: inflammation of the lung that is caused by bacterial infections
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J15.9
code billability: Billable
has ICD10 name: unspecified bacterial pneumonia

bacterial
type: Class
subclass of: morphology

pneumonia in viral diseases classified elsewhere
type: Class
subclass of: pneumonia in other diseases classified elsewhere
definition: pneumonia caused by other viral diseases
definition editor: Virginia He
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J17.1
has ICD10 name: pneumonia in viral diseases classified elsewhere

pneumonia in other diseases classified elsewhere
type: Class
subclass of: pneumonia due to pathogen
definition: pneumonia caused by other diseases
definition editor: Virginia He
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J17.8
has ICD10 name: pneumonia in other diseases classified elsewhere

Atherosclerotic heart disease of native coronary artery without angina pectoris
type: Class
subclass of: atherosclerotic heart DP of native coronary artery
definition: Thickening and loss of elasticity of the coronary arteries, leading to progressive arterial insufficiency (coronary disease).
definition editor: Virginia He
definition source: https://wexnermedical.osu.edu/heart-vascular/conditions-treatments/atherosclerosis
has icd10 code: I25.10
code billability: Non-billable
has ICD10 name: Atherosclerotic heart disease of native coronary artery

bronchopneumonia
type: Class
subclass of: viral pneumonia
definition: a lung infection that inflames and infects the aveoli
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/bronchopneumonia#:~:text=Bronchopneumonia%20is%20a%20type%20of,can%20be%20mild%20or%20severe
has icd10 code: J18.0
code billability: Billable
has ICD10 name: bronchopneumonia, unspecified organism

old myocardial infarction DP
type: Class
subclass of: chronic ischemic heart DP
subclass of: Restriction
  on property: has process profile
  some values from: myocardial disease profile
definition: Documented history of previous myocardial infarction, a sudden and sometimes fatal occurrence of coronary thrombosis, typically resulting in the death of part of a heart muscle. Also known as heart attack.
definition: https://www.heart.org/en/health-topics/heart-attack/about-heart-attacks
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I25-/I25.2
has icd10 code: I25.2
code billability: Billable
has ICD10 name: Old myocardial infarction

lobar pneumonia
type: Class
subclass of: viral pneumonia
definition: a form of pneumonia characterized by inflammatory exudate within the intra-alveolar space
definition editor: Virginia He, Justin Song
definition source: en.wikipedia.org/wiki/Lobar_pneumonia
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J18-/J18.1
has icd10 code: J18.1
code billability: Billable
has ICD10 name: Lobar pneumonia, unspecified organism

other pneumonia
type: Class
subclass of: pneumonia due to pathogen
definition: A lung infection caused by an unspecified pathogen
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J18.8
code billability: Billable
has ICD10 name: Other pneumonia, unspecified organism

pneumonia, unspecified organism
type: Class
subclass of: pneumonia due to pathogen
definition: An infection of one or both lungs
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pneumonia
has icd10 code: J18.9
code billability: Billable
has ICD10 name: pneumonia, unspecified organism

acute bronchitis
type: Class
subclass of: other acute lower respiratory infections
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: lower respiratoy tract infection that causes reversible bronchia inflammation
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20.9
has icd10 code: J20.9
code billability: Billable
has ICD10 name: Acute bronchitis, unspecified

acute upper respiratory infections
type: Class
subclass of: respiratory infections (NEW)
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: contagious infection of upper respiratory tract
definition source: https://www.healthline.com/health/acute-upper-respiratory-infection
has icd10 code: J00-J06
has ICD10 name: Acute upper respiratory infections

other acute lower respiratory infections
type: Class
subclass of: respiratory infections (NEW)
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: contagious infection of lower respiratory tract
has icd10 code: J20-J22
has ICD10 name: Other acute lower respiratory infections

unspecified acute lower respiratory tract infection
type: Class
subclass of: other acute lower respiratory infections
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: acute infection that affects the lower respiratory tract.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J22-/J22
has icd10 code: J22
code billability: Billable
has ICD10 name: unspecified acute lower respiratory infection

chronic lower respiratory diseases
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: chronic infection of lower respiratory tract
has icd10 code: J40-J47
has ICD10 name: chronic lower respiratory diseases

centrilobular emphysema
type: Class
subclass of: chronic lower respiratory diseases
definition: a chronic pulmonary disease that obstructs bloodlflow
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.2
has icd10 code: J43.2
code billability: Billable
has ICD10 name: centrilobular emphysema

other chronic obstructive pulmonary disease
type: Class
subclass of: chronic obstructive pulmonary disease (NEW)
definition: a chronic inflammatory lung disease that causes obstructed airflow from the lungs
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44
has icd10 code: J44
code billability: Non-billable
has ICD10 name: Other chronic obstructive pulmonsry disease

chronic obstructive pulmonary disease with acute lower respiratory infection
type: Class
subclass of: chronic obstructive pulmonary disease (NEW)
definition: a chronic inflammatory lung disease that causes obstructed airflow from the lungs
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.0
has icd10 code: J44.0
code billability: Billable
has ICD10 name: Chronic obstructive pulmonary disease with (acute) lower respiratory infection

chronic obstructive pulmonary disease with acute exacerbation
type: Class
subclass of: chronic obstructive pulmonary disease (NEW)
definition: a chronic inflammatory lung disease that causes airway inflammation and reduced air flow from exacerbations
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.1
has icd10 code: J44.1
code billability: Billable
has ICD10 name: Chronic obstructive pulmonary disease with (acute) lower respiratory infection

other specified chronic obstructive pulmonary disease
type: Class
subclass of: chronic obstructive pulmonary disease (NEW)
definition: a chronic inflammatory lung disease that causes obstructed airflow from the lungs
definition editor: Virginia He
definition source: https://medlineplus.gov/ency/article/000091.htm
has icd10 code: J44.8
has ICD10 name: other specified chronic obstructive pulmonary disease

chronic obstructive pulmonary disease, unspecified
type: Class
subclass of: chronic obstructive pulmonary disease (NEW)
definition: a chronic inflammatory lung disease that causes permanent damage to the lungs, making it hard to breathe
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.9
has icd10 code: J44.9
code billability: Billable
has ICD10 name: chronic obstructive pulmonary disease, unspecified

myocardial disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

asthma
type: Class
subclass of: chronic lower respiratory diseases
definition: a chronic disease in which the bronchial airways in the lungs become narrowed and swollen, making it difficult to breathe
definition editor: Virginia He
definition source: https://www.healthline.com/health/asthma
has icd10 code: J45.9
code billability: Non-billable
has ICD10 name: other and unspecified asthma

uncomplicated asthma
type: Class
subclass of: asthma
definition: Bronchial airways in the lungs become narrowed and swollen, making it hard to breathe
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/asthma
has icd10 code: J45.909
code billability: Billable
has ICD10 name: unspecified asthma, uncomplicated

bronchiectasis
type: Class
subclass of: chronic lower respiratory diseases
definition: a condition where the bronchial tubes of the lungs are permanently damaged, widened, and thickened
definition editor: Virginia He
definition source: https://www.healthline.com/health/bronchiectasis
has icd10 code: J47
code billability: Non-billable
has ICD10 name: Bronchiectasis

lung disease processes due to external agents
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: occurs in
  some values from: lung
definition: conditions of the lng caused by outside agents
definition editor: Virginia He
has icd10 code: J60-J70
has ICD10 name: Lung diseases due to external agents

pneumonitis due to inhalation of food and vomit
type: Class
subclass of: lung disease processes due to external agents
definition editor: Virginia He
definition source: https://www.healthline.com/health/pneumonitis
has icd10 code: J69.0
code billability: Billable
code billability: Inflammation of the lung tissue; noninfectious causes of lung inflammation
has ICD10 name: Pneumonitis due to inhalation of food and vomit

other respiratory diseases affecting the interstitum
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: other
definition: respiratory diseases affecting the interstitum, a fluid-filled space between a structural barrier (ie cell wall, skin) and internal structures (ie organs, muscles).
definition editor: Virginia He
has icd10 code: J80-J84
has ICD10 name: Other respiratory diseases principally affecting the interstitum

acute respiratory distress syndrome
type: Class
subclass of: other respiratory diseases affecting the interstitum
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: fluids fill up the lung's air sacs, causing the lung to not function properly
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/acute-respiratory-distress-syndrome
has icd10 code: J80
code billability: Billable
has ICD10 name: Acute respiratory distress syndrome

pulmonary edema
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition: extravascular accumulation of fluid in the pulmonary tissue and air sacs
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J81-/J81
has icd10 code: J81
code billability: Non-billable
has ICD10 name: Pulmonary edema

other interstitial pulmonary diseases with fibrosis
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition: extravascular accumulation of fluid in the pulmonary tissue and air sacs
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J84-/J84.1
has icd10 code: J84.1
code billability: Non-billable
has ICD10 name: Other interstitial pulmonary diseases with fibrosis

interstitial pulmonary disease, unspecified
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition: diseases that inflame or scar the lungs
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J84-/J84.9
has icd10 code: J84.9
code billability: Billable
has ICD10 name: Interstitial pulmonary disease, unspecified

other diseases of the pleura
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: other
definition: diseases affecting the pleura, a membrane that lines the thorax
definition editor: Virginia He
definition source: https://www.merriam-webster.com/dictionary/pleura
has icd10 code: J90-J94
has ICD10 name: Other diseases of the pleura

pleural effusion, not elsewhere classified
type: Class
subclass of: other diseases of the pleura
definition: increased amounts of fluid in pleural cavity
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/pleural-effusion
has icd10 code: J90
code billability: Billable
has ICD10 name: Pleural effusion, not elsewhere classified

pleural effusion in conditions classified elsewhere
type: Class
subclass of: other diseases of the pleura
definition: increased amounts of fluid between the thin layers of tissue lining the lung and wall of the chest cavity
definition editor: Virginia He
definition source: https://www.healthline.com/health/pleural-effusion
has icd10 code: J91
code billability: Non-billable
has ICD10 name: Pleural effusion, not elsewhere classified

ischemic cardiomyopathy DP
type: Class
subclass of: chronic ischemic heart DP
subclass of: Restriction
  on property: has process profile
  some values from: myocardial disease profile
definition: https://www.uofmhealth.org/health-library/tx4090abc
definition: the heart's ability to pump blood is decreased because the left ventricle is weak. This is caused by a lack of blood supply to the heart muscle caused by coronary artery disease and heart attacks.
definition editor: Virginia He
has icd10 code: I25.5
code billability: Billable
has ICD10 name: Ischemic cardiomyopathy

other diseases of the respiratory system
type: Class
subclass of: disease (process) in the respiratory system
subclass of: Restriction
  on property: has quality
  some values from: other
definition: diseases affecting the respiratory system
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99
has icd10 code: J96-J99
has ICD10 name: Other diseases of the respiratory system

acute respiratory failure
type: Class
subclass of: respiratory failure (NEW)
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: occurs when fluid builds up in air sacs of lungs
definition editor: Virginia He, Oliver He
definition source: https://www.healthline.com/health/acute-respiratory-failure
has icd10 code: J96.0
code billability: Non-billable
has ICD10 name: acute respiratory failure

acute respiratory failure, unspecified whether with hypoxia or hypercapnia
type: Class
subclass of: acute respiratory failure
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: acute respiratory failure, unsure if it is hypoxemic (not enough oxygen, normal CO2 levels) or hypercapnic (too much CO2, oxygen normal or too low)
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/acute-respiratory-failure
has icd10 code: J96.00
code billability: Billable
has ICD10 name: acute respiratory failure, unspecified whether with hypoxia or hypercapnia

acute respiratory failure with hypoxia
type: Class
subclass of: acute respiratory failure
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: acute respiratory failure where a portion of the body is hypoxemic (not enough oxygen, normal CO2 levels)
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/acute-respiratory-failure
has icd10 code: J96.01
code billability: Billable
has ICD10 name: acute respiratory failure with hypoxia

chronic respiratory failure
type: Class
subclass of: respiratory failure (NEW)
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: respiratory system is unable to function properly; is long-term (chronic)
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/chronic-respiratory-failure
has icd10 code: J96.1
code billability: Non-billable
has ICD10 name: chronic respiratory failure

acute and chronic respiratory failure
type: Class
subclass of: respiratory failure (NEW)
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: respiratory system is unable to function properly; is long-term (chronic) or short-term (acute)
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/chronic-respiratory-failure
has icd10 code: J96.2
code billability: Non-billable
has ICD10 name: acute and chronic respiratory failure

acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia
type: Class
subclass of: acute and chronic respiratory failure
definition: respiratory system is unable to function properly; is long-term (chronic) or short-term (acute); can be with hypoxia (too little oxygen) or hypercapnia (too much CO2, normal/low oxygen)
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/chronic-respiratory-failure
has icd10 code: J96.20
code billability: Billable
has ICD10 name: acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia

respiratory failure, unspecified
type: Class
subclass of: respiratory failure (NEW)
subclass of: Restriction
  on property: occurs in
  some values from: lung
definition: respiratory system has been attacked, used to specify symptoms
definition editor: Virginia He, Justin Song
definition source: https://icd.codes/icd10cm/J9600#:~:text=J96.,whether%20with%20hypoxia%20or%20hypercapnia
has icd10 code: J96.9
code billability: Non-billable
has ICD10 name: Respiratory failure, unspecified

respiratory failure, unspecified whether with hypoxmia or hypercapnia
type: Class
subclass of: respiratory failure, unspecified
definition: respiratory system has been damaged, unspecified whether there is too much CO2 (hypercapnia) or too little oxygen (hypoxmia) in the body
definition editor: Virginia He, Justin Song
definition source: https://medlineplus.gov/respiratoryfailure.html
has icd10 code: J96.90
code billability: Billable
has ICD10 name: Respiratory failure, unspecified whether with hypoxia or hypercapnia

atelectasis
type: Class
subclass of: other diseases of the respiratory system
definition: when the alveoli (helps exchange oxygen in air for CO2), don't fill with air
definition editor: Virginia He
definition source: https://www.healthline.com/health/atelectasis
has icd10 code: J98.11
code billability: Billable
has ICD10 name: Atelectasis

other disorders of the lung
type: Class
subclass of: other diseases of the respiratory system
definition: disorders affecting the lungs, ie asthma, COPD, influenza, etc.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.4
has icd10 code: J98.4
code billability: Billable
has ICD10 name: Other disorders of the lung

other sepcified respiratory disorders
type: Class
subclass of: other diseases of the respiratory system
definition: conditions affecting the respiratory system
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.8
has icd10 code: J98.8
code billability: Billable
has ICD10 name: Other specified respiratory disorders

coronary atherosclerosis DP due to lipid rich plaque
type: Class
subclass of: chronic ischemic heart DP
definition: https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/symptoms-causes/syc-20350569
definition: when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff — sometimes restricting blood flow to your organs and tissues.
definition editor: Virginia He
has icd10 code: I25.8
code billability: Billable
has ICD10 name: Ischemic cardiomyopathy

chronic ischemic heart DP, unspecified
type: Class
subclass of: chronic ischemic heart DP
definition: Ischemic heart disease is the term given to heart problems caused by narrowed heart (coronary) arteries that supply blood to the heart muscle. It's most often it is caused by buildup of plaque, called atherosclerosis.
definition: https://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/symptoms-causes/syc-20350613
definition editor: Virginia He
has icd10 code: I25.9
code billability: Billable
has ICD10 name: Chronic ischemic heart disease, unspecified

pulmonary heart DP and disease processes of pulmonary circulation
type: Class
subclass of: disease (process) of the circulatory system
definition: the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance or high blood pressure in the lungs.
definition editor: Virginia He
definition source: https://en.wikipedia.org/wiki/Pulmonary_heart_disease#:~:text=Pulmonary%20heart%20disease%2C%20also%20known,blood%20pressure%20in%20the%20lungs.
has icd10 code: I26-I28
code billability: Section
has ICD10 name: Pulmonary heart disease and diseases of pulmonary circulation

pulmonary embolism DP without acute cor pulmonale
type: Class
subclass of: pulmonary heart DP and disease processes of pulmonary circulation
definition: A blockage of an artery in the lungs by a foreign substance
definition: https://en.wikipedia.org/wiki/Pulmonary_embolism
definition editor: Virginia He, Justin Song
has icd10 code: I26.9
code billability: Non-billable
has ICD10 name: pulmonary embolism without acute cor pulmonale

cardiac arrest DP
type: Class
subclass of: disease (process) of the circulatory system
definition: A disorder characterized by cessation of the pumping function of the heart.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I46-
has icd10 code: I46
code billability: Non-billable
has ICD10 name: Cardiac arrest

cardiac arrest, cause unspecified
type: Class
subclass of: cardiac arrest DP
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: A disorder characterized by cessation of the pumping function of the heart.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I46-/I46.9
has icd10 code: I46.9
code billability: Billable
has ICD10 name: Cardiac arrest, cause unspecified

supraventricular tachycardia
type: Class
subclass of: disease (process) of the circulatory system
subclass of: Restriction
  on property: has process profile
  some values from: supraventricular disease profile
definition: abnormally fast heartbeat. It's a broad term that includes many forms of heart rhythm problems
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/supraventricular-tachycardia/symptoms-causes/syc-20355243#:~:text=Supraventricular%20tachycardia%20(SVT)%2C%20also,the%20atria%20or%20AV%20node.
has icd10 code: I47.1
code billability: Billable
has ICD10 name: Supraventricular tachycardia

atrial fibrillation and flutter DP
type: Class
subclass of: disease (process) of the circulatory system
subclass of: Restriction
  on property: has process profile
  some values from: atrial disease profile
definition: In atrial fibrillation, the atria beat irregularly. In atrial flutter, the atria beat regularly, but faster than usual and more often than the ventricles
definition editor: Virginia He
definition source: https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/ask-the-experts/atrial-flutter#:~:text=Normally%2C%20the%20top%20chambers%20(atria,to%20every%20one%20ventricular%20beat.
has icd10 code: I48
code billability: Non-billable
has ICD10 name: Atrial fibrillation and flutter

atrial disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

supraventricular disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

paroxysmal atrial fibrillation DP
type: Class
subclass of: atrial fibrillation and flutter DP
definition: a rapid, erratic heart rate begins suddenly and then stops on its own within 7 days
definition editor: Virginia He
definition source: https://www.medicalnewstoday.com/articles/316281
has icd10 code: I48.0
code billability: Billable
has ICD10 name: paroxysmal atrial fibrillation

persistent atrial fibrillation DP
type: Class
subclass of: atrial fibrillation and flutter DP
definition: refers to AF that occurs for longer than 7 days and ends spontaneously or with treatment
definition editor: Virginia He, Justin Song
definition source: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/atrial-fibrillation/#:~:text=1,or%20that%20is%20not%20treated.
has icd10 code: I48.1
code billability: Non-billable
has ICD10 name: Persistent atrial fibrillation

chronic atrial fibrillation DP
type: Class
subclass of: atrial fibrillation and flutter DP
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: a type of heart arrhythmia that causes the top chambers of your heart, the atria, to quiver and beat irregularly. Lasts over a week.
definition editor: Virginia He
definition source: https://www.healthline.com/health/atrial-fibrillation/chronic#:~:text=Overview,lasting%20longer%20than%20one%20week.
has icd10 code: I48.2
code billability: Non-billable
has ICD10 name: chronic atrial fibrillation

cardiac arrhythmia DP, unspecified
type: Class
subclass of: disease (process) of the circulatory system
definition: A problem with the rate or rhythm of your heartbeat. It means that your heart beats too quickly, too slowly, or with an irregular pattern
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I49-/I49.9
has icd10 code: I49.9
code billability: Billable
has ICD10 name: Cardiac arrhythmia, unspecified

unspecified atrial fibrillation and atrial flutter DP
type: Class
subclass of: atrial fibrillation and flutter DP
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: very fast electrical discharge patterns that make the atria contract very rapidly, causing them to contract faster and less efficiently than normal.
definition editor: Virginia He
definition source: https://www.merckmanuals.com/home/heart-and-blood-vessel-disorders/abnormal-heart-rhythms/atrial-fibrillation-and-atrial-flutter#:~:text=Atrial%20fibrillation%20and%20atrial%20flutter%20are%20very%20fast%20electrical%20discharge,and%20less%20efficiently%20than%20normal.
has icd10 code: I48.9
code billability: Non-billable
has ICD10 name: Unspecified atrial fibrillation and atrial flutter

left bundle-branch block DP, unspecified
type: Class
subclass of: atrioventricular and left bundle-branch block DP
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: a common electrocardiographic (ECG) abnormality seen in patients whose normal cardiac conduction down both anterior and posterior left fascicles of the His-Purkinje system is compromised.
definition editor: Virginia He
definition source: https://www.ncbi.nlm.nih.gov/books/NBK482167/#:~:text=D%2C%20Hicks%20GJ.-,Introduction,His%2DPurkinje%20system%20is%20compromised.
has icd10 code: I44.7
code billability: Billable
has ICD10 name: Left bundle-branch block

atrioventricular and left bundle-branch block DP
type: Class
subclass of: disease (process) of the circulatory system
subclass of: Restriction
  on property: has process profile
  some values from: atrioventricular disease profile
definition: Electrical impulses that cause your heart to beat originate in the upper right chamber of the heart and travel to the lower chambers. In bundle branch block, the pathway that these impulses travel on is delayed or blocked.
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/bundle-branch-block/symptoms-causes/syc-20370514#:~:text=Bundle%20branch%20block-,Bundle%20branch%20block,on%20is%20delayed%20or%20blocked.
has icd10 code: I44
code billability: Non-billable
has ICD10 name: Atrioventricular and left bundle-branch block

heart failure DP
type: Class
subclass of: disease (process) of the circulatory system
definition: A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-
has icd10 code: I50
code billability: Non-billable
has ICD10 name: heart failure

atrioventricular disease profile
type: Class
subclass of: disease profile
definition editor: Oliver He, Eric Wang, Virginia He

heart failure, unspecified
type: Class
subclass of: heart failure DP
definition: A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-
has icd10 code: I50.9
code billability: Billable
has ICD10 name: heart failure, unspecified

stroke DP, not specified as haemorrhage or infarction
type: Class
subclass of: disease (process) of the circulatory system
definition: An episode of acute neurological dysfunction presumed to be caused by ischemia or hemorrhage, persisting ≥24 hours or until death
definition editor: Virginia He, Justin Song
definition source: https://www.ahajournals.org/doi/pdf/10.1161/str.0b013e318296aeca#:~:text=Definition%20of%20stroke%2C%20not%20otherwise,Page%204
has icd10 code: I64
has ICD10 name: Stroke, not specified as haemorrhage or infarction

sequelae DP of stroke, not specified as haemorrhage or infarction
type: Class
subclass of: disease (process) of the circulatory system
definition: residual effects or conditions produced after the acute phase of a stroke
definition editor: Virginia He, Justin Song
definition source: http://bok.ahima.org/doc#.XxsDs5NKg6U
has icd10 code: I69.4
has ICD10 name: Sequelae of stroke, not specified as haemorrhage or infarction

atherosclerosis DP of native arteries of extremities with gangrene
type: Class
subclass of: atherosclerosis DP
definition: When plaque (fatty deposits) clogs your arteries
definition editor: Virginia He
definition source: https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/atherosclerosis#:~:text=Atherosclerosis%20and%20cholesterol,of%20the%20blood%20vessel%20thickens.
has icd10 code: I70.2
code billability: Non-billable
has ICD10 name: Atherosclerosis of native arteries of extremities with gangrene

atherosclerosis DP
type: Class
subclass of: disease (process) of the circulatory system
definition: A thickening and loss of elasticity of the walls of arteries that occurs with formation of atherosclerotic plaques within the arterial intima.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I70-I79/I70-
has icd10 code: I70
code billability: Non-billable
has ICD10 name: Atherosclerosis

disease processes of veins, lymphatic vessels and lymph nodes
type: Class
subclass of: disease (process) of the circulatory system
definition: Diseases of the lymphatic system, a network of tissues and organs.
definition editor: Virginia He
definition source: https://medlineplus.gov/lymphaticdiseases.html
has icd10 code: I80-I89
has ICD10 name: Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified

venous insufficiency DP
type: Class
subclass of: disease processes of veins, lymphatic vessels and lymph nodes
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: a condition that occurs when the venous wall and/or valves in the leg veins are not working effectively, making it difficult for blood to return to the heart from the legs.
definition editor: Virginia He
definition source: https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi#:~:text=Chronic%20venous%20insufficiency%20(CVI)%20is,this%20pooling%20is%20called%20stasis.
has icd10 code: I87.2
code billability: Billable
has ICD10 name: Venous insufficiency (chronic) (peripheral)

hypotension DP
type: Class
subclass of: disease (process) of the circulatory system
definition: A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I95-
has icd10 code: I95
code billability: Non-billable
has ICD10 name: Hypotension

orthostatic hypotension DP
type: Class
subclass of: hypotension DP
definition: A significant drop in blood pressure after assuming a standing position
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I95-/I95.1
has icd10 code: I95.1
code billability: Billable
has ICD10 name: Orthostatic hypotension

other hypotension DP
type: Class
subclass of: hypotension DP
definition: A decrease in systemic blood pressure below accepted low values (pressures less than 90/60 are recognized as hypotensive)
definition editor: Virginia He, Justin Song
definition source: https://www.ncbi.nlm.nih.gov/books/NBK499961/#:~:text=Hypotension%20is%20a%20decrease%20in,because%20it%20is%20typically%20asymptomatic.
has icd10 code: I95.8
code billability: Non-billable
has ICD10 name: Other hypotension

hypotension DP, unspecified
type: Class
subclass of: hypotension DP
definition: A decrease in systemic blood pressure below accepted low values (pressures less than 90/60 are recognized as hypotensive)
definition editor: Virginia He, Justin Song
definition source: https://www.ncbi.nlm.nih.gov/books/NBK499961/#:~:text=Hypotension%20is%20a%20decrease%20in,because%20it%20is%20typically%20asymptomatic.
has icd10 code: I95.9
code billability: Billable
has ICD10 name: Hypotension, unspecified

Other postprocedural complications and disorders of the circulatory system
type: Class
subclass of: disease (process) of the circulatory system
definition: any cardiac complications occurring in the postanesthetic care unit (PACU)
definition editor: Virginia He
definition source: https://accessanesthesiology.mhmedical.com/content.aspx
has icd10 code: I97.89
code billability: Billable
code billability: Non-billable
has ICD10 name: Other postprocedural complications and disorders of the circulatory system, not elsewhere classified

antibiotic resistance
type: Class
subclass of: immune system DP
definition editor: Virginia He
definition source: enzymes that confer resistance to most beta-lactam antibiotics, including penicillins, cephalosporins, and the monobactam aztreonam
definition source: https://www.uptodate.com/contents/extended-spectrum-beta-lactamases#:~:text=Extended%2Dspectrum%20beta%2Dlactamases%20(,cephalosporins%2C%20and%20the%20monobactam%20aztreonam.&text=The%20first%20plasmid%2Dmediated%20beta,in%20Greece%20in%20the%201960s.
has icd10 code: U82.2
has ICD10 name: Extended spectrum betalactamase (ESBL) resistance

bacterial disease (process)
type: Class
subclass of: infectious and parasitic disease (process)

coronavirus infection DP, unspecified
type: Class
subclass of: viral infection DP of unspecified site
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: a type of common virus that infects humans, typically leading to an upper respiratory infection
definition editor: Virginia He, Justin Song
definition source: https://www.medicinenet.com/script/main/art.asp
has icd10 code: B34.2
code billability: Billable
has ICD10 name: Coronavirus infection, unspecified

disease (process) of the genitourinary system
type: Class
subclass of: disease process
definition: Genitourinary disease involves disorders of the genital and urinary organs. These organs are involved in reproduction and urination
alternative term: disease of the genitourinary system
definition source: https://www.encyclopedia.com/education/encyclopedias-almanacs-transcripts-and-maps/genitourinary-disease#:~:text=Genitourinary%20disease%20involves%20disorders%20of,and%20the%20uterus%20in%20females.
has icd10 code: N00-N99
has ICD10 name: Diseases of the genitourinary system

Erysipelas
type: Class
subclass of: bacterial disease (process)
definition: Erysipelas is a relatively common bacterial infection of the superficial layer of the skin (upper dermis), extending to the superficial lymphatic vessels within the skin, characterized by a raised, well-defined, tender, bright red rash, typically on the face or legs, but which can occur anywhere on the skin. It is a form of cellulitis and is potentially serious. Erysipelas is usually caused by the bacteria Streptococcus pyogenes.
definition editor: Grace Whah, Oliver He
alternative term: St. Anthony's fire
has icd10 code: A46
source: https://en.wikipedia.org/wiki/Erysipelas
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A46-/A46

acute pyelonephritis DP
type: Class
subclass of: renal tubulo-interstitial disease processes
subclass of: Restriction
  on property: has process profile
  some values from: acute disease profile
definition: a bacterial infection causing inflammation of the kidneys and is one of the most common diseases of the kidney.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N10-/N10
definition source: https://www.ncbi.nlm.nih.gov/books/NBK519537/#:~:text=Acute%20pyelonephritis%20is%20a%20bacterial,kidneys%20and%20their%20collecting%20systems.
has icd10 code: N10
code billability: Billable
has ICD10 name: Acute pyelonephritis

acute kidney failure DP
type: Class
subclass of: acute kidney failure or chronic kidney DP
subclass of: Restriction
  on property: occurs in
  some values from: kidney
subclass of: Restriction
  on property: has process profile
  some values from: acute disease profile
definition: A disorder characterized by the acute loss of renal function
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17
has icd10 code: N17
code billability: Non-Billable
has ICD10 name: Acute kidney failure

acute kidney failure or chronic kidney DP
type: Class
subclass of: disease (process) of the genitourinary system
subclass of: Restriction
  on property: occurs in
  some values from: kidney
subclass of: Restriction
  on property: has process profile
  some values from: Class
    union of: acute disease profile
    union of: chronic disease profile
definition: A disorder characterized by the acute loss of renal function
definition editor: Virginia He
definition source: https://myhealth.alberta.ca/Health/Pages/conditions.aspx?hwid=aa106178&lang=en-ca#:~:text=Kidney%20problems%20can%20develop%20suddenly,reversible%20than%20chronic%20kidney%20failure.
has icd10 code: N17-N19.9
has ICD10 name: Acute kidney failure and chronic kidney disease

acute kidney failure with tubular necrosis DP
type: Class
subclass of: acute kidney failure DP
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: Acute kidney failure resulting from destruction of epithelial cells of the kidney tubules.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17.0
has icd10 code: N17.0
code billability: Billable
has ICD10 name: Acute kidney failure with tubular necrosis

other acute kidney failure DP
type: Class
subclass of: acute kidney failure DP
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: kidney is no longer able to filter blood.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17.8
definition source: https://www.mayoclinic.org/diseases-conditions/kidney-failure/symptoms-causes/syc-20369048
has icd10 code: N17.8
code billability: Billable
has ICD10 name: other acute kidney failure
source: https://icdlist.com/icd-10/N17.8
comment: N17.8 is a billable code used to specify a medical diagnosis of other acute kidney failure. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code N17.8 might also be used to specify conditions or terms like acute renal failure due to ischemia or ischemic nephropathy or post-renal renal failure.

acute kidney failure DP, unspecified
type: Class
subclass of: acute kidney failure DP
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: kidney(s)'s functions are compromised. This will be a short term problem
definition editor: Virginia He, Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/kidney-failure/symptoms-causes/syc-20369048
has icd10 code: N17.9
code billability: Billable
has ICD10 name: other acute kidney failure

chronic kidney disease DP
type: Class
subclass of: acute kidney failure or chronic kidney DP
subclass of: Restriction
  on property: has quality
  some values from: chronic
definition: A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-
has icd10 code: N18
code billability: Non-Billable
has ICD10 name: Chronic kidney disease

chronic kidney DP, stage 3
type: Class
subclass of: chronic kidney disease DP
definition: A disease that causes moderate kidney damage. A person is more likely to develop complications of kidney disease such as high blood pressure, anemia, and/or early bone disease.
definition editor: Virginia He
definition source: https://www.niddk.nih.gov/health-information/kidney-disease/anemia
has icd10 code: N18.3
code billability: Billable
has ICD10 name: Chronic kidney disease, stage 3 (moderate)

chronic kidney DP, stage 4
type: Class
subclass of: chronic kidney disease DP
definition: kidneys are moderately or severely damaged and are not working as they should. Stage 4 kidney disease should be taken very seriously – it is the last stage before kidney failure.
definition editor: Virginia He, Justin Song
definition source: https://www.kidneyfund.org/kidney-disease/chronic-kidney-disease-ckd/stages-of-chronic-kidney-disease/#:~:text=Stage%204%20CKD%20means%20you,last%20stage%20before%20kidney%20failure.
has icd10 code: N18.4
code billability: Billable
has ICD10 name: Chronic kidney disease, stage 4 (severe)

chronic kidney DP, stage 5
type: Class
subclass of: chronic kidney disease DP
definition: Chronic, irreversible renal failure.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.5
has icd10 code: N18.5
code billability: Billable
has ICD10 name: Chronic kidney disease, stage 5

end stage renal DP
type: Class
subclass of: chronic kidney disease DP
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: Chronic, irreversible renal failure.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.6
has icd10 code: N18.6
code billability: Billable
has ICD10 name: End stage renal disease

chronic kidney DP unspecified
type: Class
subclass of: chronic kidney disease DP
definition: A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.9
has icd10 code: N18.9
code billability: Billable
has ICD10 name: Chronic kidney disease, unspecified

unspecified kidney failure DP
type: Class
subclass of: disease (process) of the genitourinary system
subclass of: Restriction
  on property: occurs in
  some values from: kidney
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of renal insufficiency.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N19-/N19
has icd10 code: N19
code billability: Billable
has ICD10 name: Unspecified kidney failure

urinary tract infection DP
type: Class
subclass of: disease (process) of the genitourinary system
definition: the unirary tract is infected and cannot function properly
definition editor: Virginia He, Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/urinary-tract-infection/symptoms-causes/syc-20353447
has icd10 code: N39.0
code billability: Billable
has ICD10 name: urinary tract infection, site not specified

benign prostatic hyperplasia DP
type: Class
subclass of: DP of male genital organs
definition: A benign (noncancerous) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53/N40-/N40
has icd10 code: N40
code billability: Non-billable
has ICD10 name: Benign prostatic hyperplasia

acute prostatitis DP
type: Class
subclass of: DP of male genital organs
definition: when your prostate gland becomes suddenly inflamed
definition editor: Virginia He
definition source: https://www.healthline.com/health/prostatitis-bacterial-acute#:~:text=Acute%20prostatitis%20happens%20when%20your,this%20fluid%20into%20your%20urethra.
has icd10 code: N41.0
code billability: Billable
has ICD10 name: Acute prostatitis

DP of male genital organs
type: Class
subclass of: disease (process) of the genitourinary system
definition: Diseases that affect the male reproductive and genital organs
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53
has icd10 code: N40-N53
has ICD10 name: Diseases of male genital organs

iron deficiency anemia DP
type: Class
subclass of: disease (process) of the circulatory system
definition: Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D50-D53/D50-
has icd10 code: D50
code billability: Non-billable
has ICD10 name: Iron deficiency anemia

other iron deficiency anemia DP
type: Class
subclass of: iron deficiency anemia DP
definition: caused by a shortage of iron in your body.
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360#:~:text=Iron%20deficiency%20anemia.,hemoglobin%20for%20red%20blood%20cells.
has icd10 code: D50.8
code billability: Billable
has ICD10 name: Other iron deficiency anemias

iron deficiency anemia, unspecified
type: Class
subclass of: iron deficiency anemia DP
definition: Iron deficiency anemia is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells.
definition editor: Virginia He, Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/iron-deficiency-anemia/symptoms-causes/syc-20355034#:~:text=Iron%20deficiency%20anemia%20is%20a,is%20due%20to%20insufficient%20iron.
has icd10 code: D50.9
code billability: Billable
has ICD10 name: Iron deficiency anemia, unspecified

Hb-SS DP with crisis
type: Class
subclass of: disease (process) of the circulatory system
definition: It occurs when you inherit copies of the hemoglobin S gene from both parents
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/sickle-cell-anemia#complications
has icd10 code: D57.0
code billability: Non-billable
has ICD10 name: Hb-SS disease with crisis

acute posthemorrhagic anemia DP
type: Class
subclass of: other anemias and bone marrow failure syndromes
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: a condition in which a person quickly loses a large volume of circulating hemoglobin.
definition editor: Virginia He
definition source: https://en.wikipedia.org/wiki/List_of_hematologic_conditions#:~:text=Acute%20posthemorrhagic%20anemia%20(also%20known,a%20large%20loss%20of%20blood.
has icd10 code: D62
code billability: Billable
has ICD10 name: Acute posthemorrhagic anemia

other anemias and bone marrow failure syndromes
type: Class
subclass of: disease (process) of the circulatory system
definition: failure of the bone marrow to produce blood
definition editor: Virginia He
definition source: https://dceg.cancer.gov/research/what-we-study/bone-marrow-failure-syndromes#:~:text=The%20inherited%20bone%20marrow%20failure,history%20of%20the%20same%20disorder.
has icd10 code: D60-D64
has ICD10 name: Aplastic and other anemias and other bone marrow failure syndromes

anemia DP in other chronic diseases classified elsewhere
type: Class
subclass of: other anemias and bone marrow failure syndromes
definition: a condition marked by a deficiency of red blood cells or of hemoglobin in the blood
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D63-/D63.8#:~:text=Anemia%20in%20other%20chronic%20diseases%20classified%20elsewhere,-2016%202017%202018&text=Code%20Manifestation%20Code-,D63.,ICD%2D10%2DCM%20D63.&text=This%20is%20the%20American%20ICD%2D10%2DCM%20version%20of%20D63.
has icd10 code: D63.8
code billability: Billable
has ICD10 name: Anemia in other chronic diseases classified elsewhere

other specified anemia DP
type: Class
subclass of: other anemias and bone marrow failure syndromes
definition: decrease in the amount of red blood cells in the patient's blood stream
definition editor: Virginia He, Justin Song
definition source: https://icd.codes/icd10cm/D6489
has icd10 code: D64.8
code billability: Non-billable
has ICD10 name: Other specified anemias

anemia DP, unspecified
type: Class
subclass of: other anemias and bone marrow failure syndromes
definition: patient lacks enough red blood cells to carry oxygen to the body's tissues
definition editor: Virginia He, Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360
has icd10 code: D64.9
code billability: Billable
has ICD10 name: Anemia, unspecified

hemorrhagic disorder DP due to circulating anticoagulants
type: Class
subclass of: coagulation defects, purpura and other hemorrhagic conditions
definition: a bleeding disorder caused by circulating anticoagulants (autoantibodies that neutralize specific clotting)
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D68-/D68.3
has icd10 code: D68.3
code billability: Non-billable
has ICD10 name: Hemorrhagic disorder due to circulating anticoagulants

coagulation defects, purpura and other hemorrhagic conditions
type: Class
subclass of: disease (process) of the circulatory system
definition: Hemorrhagic diseases are caused by bleeding, or they result in bleeding
definition editor: Virginia He
definition source: https://medlineplus.gov/ency/article/002373.htm#:~:text=article%2F002373.htm-,Hemorrhagic,result%20in%20bleeding%20(hemorrhaging).
has icd10 code: D65-D69
has ICD10 name: Coagulation defects, purpura and other hemorrhagic conditions

secondary thrombocytopenia DP
type: Class
subclass of: coagulation defects, purpura and other hemorrhagic conditions
definition: abnormally low levels of thrombocytes, also known as platelets, in the blood.
definition editor: Virginia He
definition source: https://en.wikipedia.org/wiki/Thrombocytopenia#:~:text=Thrombocytopenia%20is%20a%20condition%20characterized,platelets%20per%20microliter%20of%20blood.
has icd10 code: D69.5
code billability: Non-billable
has ICD10 name: Secondary thrombocytopenia

thrombocytopenia DP, unspecified
type: Class
subclass of: coagulation defects, purpura and other hemorrhagic conditions
definition: Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.
definition editor: Virginia He
definition source: https://en.wikipedia.org/wiki/Thrombocytopenia#:~:text=Thrombocytopenia%20is%20a%20condition%20characterized,platelets%20per%20microliter%20of%20blood.
has icd10 code: D69.6
code billability: Billable
has ICD10 name: Thrombocytopenia, unspecified

neutropenia DP
type: Class
subclass of: disease (process) of the circulatory system
definition: People with neutropenia have an unusually low number of cells called neutrophils. Neutrophils are cells in your immune system that attack bacteria and other organisms when they invade your body
definition editor: Virginia He
definition source: https://www.webmd.com/a-to-z-guides/neutropenia-causes-symptoms-treatment#1
has icd10 code: D70
code billability: Non-billable
has ICD10 name: Neutropenia

other specified disorders of white blood cells.
type: Class
subclass of: disease (process) of the circulatory system
definition: white blood cell disorders effect the functionallity of the body's immune response
definition editor: Virginia He, Justin Song
definition source: https://www.healthline.com/health/blood-cell-disorders#white-blood-cell-disorders
has icd10 code: D72.8
code billability: Non-billable
has ICD10 name: Other specified disorders of white blood cells

lymphocytopenia
type: Class
subclass of: other specified disorders of white blood cells.
definition: low level of lymphocytes, which are white blood cells
definition editor: Virginia He, Justin Song
definition source: https://en.wikipedia.org/wiki/Lymphocytopenia#:~:text=Lymphocytopenia%20is%20the%20condition%20of,an%20excessive%20level%20of%20lymphocytes.
has icd10 code: D72.810
code billability: Billable
has ICD10 name: Lymphocytopenia

disorder involving the immune mechanism, unspecified
type: Class
subclass of: disease (process) of the circulatory system
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: A disorder resulting from an abnormality in the immune system
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D89-/D89.9
has icd10 code: D89.9
code billability: Billable
has ICD10 name: Disorder involving the immune mechanism, unspecified

disease (process) of the nervous system
type: Class
subclass of: disease process
subclass of: Restriction
  on property: occurs in
  some values from: nervous system
definition: a small class of medical conditions affecting the nervous system.
definition editor: Virginia He
alternative term: disease of the nervous system
definition source: https://en.wikipedia.org/wiki/Nervous_system_disease#:~:text=Nervous%20system%20diseases%2C%20also%20known,conditions%20affecting%20the%20nervous%20system.
has icd10 code: G00-G99
has ICD10 name: Diseases of the nervous system

acquired coagulation factor deficiency
type: Class
subclass of: coagulation defects, purpura and other hemorrhagic conditions
definition: Deficiency of a coagulation factor (proteins in the blood that help control bleeding) that is not caused by genetic alterations. Causes include vitamin k deficiency, amyloidosis, and severe liver disease.
definition editor: Grace Whah
definition source: https://medlineplus.gov/lab-tests/coagulation-factor-tests/#:~:text=Coagulation%20factors%20are%20proteins%20in,from%20losing%20too%20much%20blood.
has icd10 code: D68.4
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D68-/D68.4

parkinson's disease process
type: Class
subclass of: disease (process) of the nervous system
definition: a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination.
definition editor: Virginia He, Justin Song
definition source: https://www.nia.nih.gov/health/parkinsons-disease#:~:text=Parkinson's%20disease%20is%20a%20brain,have%20difficulty%20walking%20and%20talking.
has icd10 code: G20
code billability: Billable
has ICD10 name: Parkinson's disease

alzheimer's disease process
type: Class
subclass of: disease (process) of the nervous system
definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30-
has icd10 code: G30
code billability: Non-billable
has ICD10 name: Alzheimer's disease

alzheimer's DP with late onset
type: Class
subclass of: alzheimer's disease process
definition: characterized by clinical symptoms and signs of AD that become apparent after the age of 60.
definition editor: Virginia He
definition source: https://www.brightfocus.org/alzheimers/article/what-your-risk-heredity-and-late-onset-alzheimers-disease#:~:text=Late%2Donset%20Alzheimer's%2C%20the%20most,and%20this%20form%20of%20Alzheimer's.
has icd10 code: G30.1
code billability: Billable
has ICD10 name: Alzheimer's disease with late onset

alzheimer's DP, unspecified
type: Class
subclass of: alzheimer's disease process
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30-/G30.9
has icd10 code: G30.9
code billability: Billable
has ICD10 name: Alzheimer's disease, unspecified

epilepsy, unspecified
type: Class
subclass of: disease (process) of the nervous system
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: a neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.9
has icd10 code: G40.9
code billability: Non-billable
has ICD10 name: Epilepsy, unspecified

sleep apnea DP
type: Class
subclass of: sleep disorders
definition: A disorder characterized by cessation of breathing for short periods during sleep.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.3
has icd10 code: G47.3
code billability: Non-billable
has ICD10 name: sleep apnea

obstructive sleep apnea DP
type: Class
subclass of: sleep apnea DP
definition: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.33
has icd10 code: G47.33
code billability: Billable
has ICD10 name: Obstructive sleep apnea (adult) (pediatric)

diabetic polyneuropathy DP
type: Class
subclass of: disease (process) of the nervous system
definition: a neurological disorder that results in diabetes
definition editor: Virginia He, Justin Song
definition source: https://www.pijn.com/en/patients/cause-of-pain/diagnoses-per-body-region/widespread-pain/diabetic-polyneuropathy#:~:text=Diabetic%20polyneuropathy%20is%20a%20neurological,nerves%20do%20not%20work%20properly.
has icd10 code: G63.2
has ICD10 name: Diabetic polyneuropathy

disease (process) of the digestive system
type: Class
subclass of: disease process
definition: any health problem that occurs in the digestive tract.
definition editor: Virginia He
alternative term: disease of the digestive system
definition source: https://medlineplus.gov/ency/article/007447.htm#:~:text=A%20digestive%20disease%20is%20any,Gallstones%2C%20cholecystitis%2C%20and%20cholangitis
has icd10 code: K00-K99
has ICD10 name: Diseases of the digestive system

gastro-esophageal reflux disease process without esophagitis
type: Class
subclass of: disease (process) of esophagus, stomach and duodenum
definition: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31/K21-/K21.9
has icd10 code: K21.9
code billability: Billable
has ICD10 name: Gastro-esophageal reflux disease without esophagitis

noninfective gastroenteritis and colitis DP, unspecified
type: Class
subclass of: noninfective enteritis and colitis (NEW)
definition: An inflammatory disorder that affects the upper and lower gastrointestinal tract; a disorder characterized by inflammation of the colon.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52/K52-/K52.9
has icd10 code: K52.9
code billability: Billable
has ICD10 name: Noninfective gastroenteritis and colitis, unspecified

constipation DP
type: Class
subclass of: functional intestinal disorders
definition: A condition in which stool becomes hard, dry, and difficult to pass, and bowel movements don't happen very often.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K59-/K59.0
has icd10 code: K59.0
code billability: Non-billable
has ICD10 name: Constipation

type 2 diabetes mellitus with hyperosmolarity
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: A complication of type 2 diabetes, involving extremely high blood sugar (glucose) level without the presence of ketones.
definition editor: Grace Whah
alternative term: HHS (Hyperglycemic hyperosmolar syndrome)
definition source: https://medlineplus.gov/ency/article/000304.htm#:~:text=Diabetic%20hyperglycemic%20hyperosmolar%20syndrome%20(HHS,without%20the%20presence%20of%20ketones.
has icd10 code: E11.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.0

other constipation DP
type: Class
subclass of: constipation DP
definition: infrequent bowel movements or difficult passage of stools that persists for several weeks or longer.
definition editor: Virginia He, Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/constipation/symptoms-causes/syc-20354253
has icd10 code: K59.09
code billability: Billable
has ICD10 name: Other constipation

functional intestinal disorders
type: Class
subclass of: other disease (process) of the intestines
definition: a problem with how your stomach and bowels function or work
definition editor: Virginia He
definition source: https://www.med.umich.edu/fbd/#:~:text=Functional%20Bowel%20Disorders%20(or%20FBD,signs%20that%20something%20is%20wrong.
has icd10 code: K59
code billability: Non-billable
has ICD10 name: Other functional intestinal disorders

functional diarrhea
type: Class
subclass of: functional intestinal disorders
definition: loose stool consistency and chronicity and absence of coexisting irritable bowel syndrome
definition editor: Virginia He, Justin Song
definition source: https://pubmed.ncbi.nlm.nih.gov/22917168/#:~:text=A%20consensus%20definition%20for%20functional,by%20a%20preceding%20infectious%20gastroenteritis.
has icd10 code: K59.1
code billability: Billable
has ICD10 name: Functional diarrhea

hemorrhage of anus and rectum DP
type: Class
subclass of: other disease (process) of the intestines
definition: bleeding in the rectum caused by various things such as infections, proctitis, etc.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.0
has icd10 code: K62.5
code billability: Non-billable
has ICD10 name: Hemorrhage of anus and rectum

toxic liver disease with cholestasis DP
type: Class
subclass of: disease (process) of the liver
definition: liver is damaged which makes it hard to digest food.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K71-/K71.0
has icd10 code: K71.0
code billability: Billable
has ICD10 name: Toxic liver disease with cholestasis

acute and subacute hepatic failure DP
type: Class
subclass of: disease (process) of the liver
definition: liver failure
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.0
has icd10 code: K72.0
code billability: Non-billable
has ICD10 name: Acute and subacute hepatic failure

melena DP
type: Class
subclass of: other diseases of the digestive system (NEW)
definition: Abnormally dark tarry feces containing blood (usually from gastrointestinal bleeding)
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.1
has icd10 code: K92.1
code billability: Billable
has ICD10 name: Melena

infectious and parasitic disease (process)
type: Class
subclass of: disease process
subclass of: Restriction
  on property: has quality
  some values from: infectious
definition: disorders caused by organisms — such as bacteria, viruses, fungi or parasites.
definition editor: Virginia He
alternative term: infectious and parasitic disease processes
definition source: https://www.mayoclinic.org/diseases-conditions/infectious-diseases/symptoms-causes/syc-20351173#:~:text=Infectious%20diseases%20are%20disorders%20caused,passed%20from%20person%20to%20person.
has icd10 code: A00-B99
has ICD10 name: Certain infectious and parasitic diseases

infectious gastroenteritis and colitis DP, unspecified
type: Class
subclass of: infectious and parasitic disease (process)
definition: A viral or bacterial infectious process affecting the large intestine.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A09-/A09
has icd10 code: A09
code billability: Billable
has ICD10 name: Infectious gastroenteritis and colitis, unspecified

sepsis DP, unspecified organism
type: Class
subclass of: infectious and parasitic disease (process)
definition: the presence of bacteria or their toxins in the blood or tissues.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A41-/A41.9
has icd10 code: A41.9
code billability: Billable
has ICD10 name: Sepsis, unspecified organism

viral infection DP of unspecified site
type: Class
subclass of: infectious and parasitic disease (process)
subclass of: Restriction
  on property: has quality
  some values from: viral
definition: A general term for diseases produced by viruses.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B25-B34/B34-
has icd10 code: B34
has ICD10 name: Viral infection of unspecified site

viral infection DP, unspecified
type: Class
subclass of: viral infection DP of unspecified site
subclass of: Restriction
  on property: has quality
  some values from: unspecified
definition: A general term for diseases produced by viruses.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B25-B34/B34-/B34.9
has icd10 code: B34.9
code billability: Billable
has ICD10 name: Viral infection, unspecified

E. coli as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: E. coli are usually harmless bacteria that help with digestion, but they can be strained and cause diarreha or worse
definition editor: Virginia He, Justin Song
definition source: https://www.webmd.com/food-recipes/food-poisoning/what-is-e-coli#1
has icd10 code: B96.2
code billability: Non-billable
has ICD10 name: Escherichia coli [E. coli ] as the cause of diseases classified elsewhere.

other specified bacterial agents as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: bacteria that infect the body cause diseases
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.8
has icd10 code: B96.8
code billability: Non-billable
has ICD10 name: Other specified bacterial agents as the cause of diseases classified elsewhere

other bacterial agents as the cause of diseases classified elsewhere
type: Class
subclass of: infectious and parasitic disease (process)
subclass of: Restriction
  on property: has quality
  some values from: bacterial
definition: bacteria that infect the body cause diseases
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-
has icd10 code: B96
code billability: Non-billable
has ICD10 name: Other specified bacterial agents as the cause of diseases classified elsewhere

viral agents as the cause of diseases
type: Class
subclass of: infectious and parasitic disease (process)
subclass of: Restriction
  on property: has quality
  some values from: viral
definition: viruses that infect the body cause diseases
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97
has icd10 code: B97
code billability: Non-billable
has ICD10 name: Viral agents as the cause of diseases classified elsewhere

coronavirus as the cause of diseases
type: Class
subclass of: viral agents as the cause of diseases
definition: a type of common virus that infects humans, typically leading to an upper respiratory infection
definition editor: Virginia He
definition source: https://www.medicinenet.com/script/main/art.asp
has icd10 code: B97.2
code billability: Non-billable
has ICD10 name: Coronavirus as the cause of diseases classified elsewhere

other coronavirus as the cause of diseases
type: Class
subclass of: viral agents as the cause of diseases
definition: a type of common virus that infects humans, typically leading to an upper respiratory infection
definition editor: Virginia He, Justin Song
definition source: https://www.medicinenet.com/script/main/art.asp
has icd10 code: B97.29
code billability: Billable
has ICD10 name: Other coronavirus as the cause of diseases classified elsewhere

other viral agents as the cause of diseases
type: Class
subclass of: viral agents as the cause of diseases
definition: infection/disease caused by a virus
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.89
has icd10 code: B97.89
code billability: Billable
has ICD10 name: Other viral agents as the cause of diseases classified elsewhere

other and unspecified infectious diseases
type: Class
subclass of: infectious and parasitic disease (process)
subclass of: Restriction
  on property: has quality
  some values from: viral
definition: Infectious diseases are disorders caused by organisms — such as bacteria, viruses, fungi or parasites.
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/infectious-diseases/symptoms-causes/syc-20351173#:~:text=Infectious%20diseases%20are%20disorders%20caused,passed%20from%20person%20to%20person.
has icd10 code: B99
code billability: Non-billable
has ICD10 name: Other and unspecified infectious diseases

neoplasm DP
type: Class
subclass of: disease process
definition: An abnormal mass of tissue that results when cells divide more than they should or do not die when they should.
definition editor: Virginia He
definition source: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/neoplasm
has icd10 code: C00-D49
has ICD10 name: Neoplasms

malignant neoplasm DP of bronchus or lung
type: Class
subclass of: other diseases of the respiratory system
subclass of: neoplasm DP
subclass of: Restriction
  on property: occurs in
  some values from: lung
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
definition editor: Virginia He
definition source: https://en.wikipedia.org/wiki/Lung_cancer#:~:text=Lung%20cancer%2C%20also%20known%20as,other%20parts%20of%20the%20body.
has icd10 code: C34.9
code billability: Non-billable
has ICD10 name: Malignant neoplasm of unspecified part of bronchus or lung

malignant neoplasm DP of breast
type: Class
subclass of: neoplasm DP
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C50-C50/C50-/C50.9
has icd10 code: C50.9
code billability: Non-billable
has ICD10 name: A primary or metastatic malignant neoplasm involving the breast.

malignant neoplasm DP of prostate
type: Class
subclass of: neoplasm DP
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: A primary or metastatic malignant tumor involving the prostate gland.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C60-C63/C61-/C61
has icd10 code: C61
code billability: Billable
has ICD10 name: Malignant neoplasm of prostate

secondary malignant neoplasm of liver and intrahepatic bile duct DP
type: Class
subclass of: neoplasm DP
subclass of: disease (process) of the liver
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: Cancer that has spread from the original (primary) tumor to the liver.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.7
has icd10 code: C78.7
code billability: Billable
has ICD10 name: Secondary malignant neoplasm of liver and intrahepatic bile duct

secondary malignant neoplasm of bone and bone marrow DP
type: Class
subclass of: neoplasm DP
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: Cancer that has spread from the original (primary) tumor to the bone.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.5
has icd10 code: C79.5
code billability: Non-billable
has ICD10 name: Secondary malignant neoplasm of bone and bone marrow

multiple myeloma DP
type: Class
subclass of: neoplasm DP
subclass of: Restriction
  on property: has process profile
  some values from: malignant disease profile
definition: A malignancy of mature plasma cells engaging in monoclonal immunoglobulin production.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C90-/C90.0
has icd10 code: C90.0
code billability: Non-billable
has ICD10 name: Multiple myeloma

disease (process) of the eye and adnexa
type: Class
subclass of: disease process
definition: Diseases and conditions affecting the eyes
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/H00-H59
has icd10 code: H00-H59
has ICD10 name: Diseases of the eye and adnexa

degeneration of macula and posterior pole
type: Class
subclass of: disorders of choroid and retina (NEW)
definition: a common eye disorder among people over 50. It causes blurred or reduced central vision, due to thinning of the macula
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/dry-macular-degeneration/symptoms-causes/syc-20350375#:~:text=Dry%20macular%20degeneration%20is%20a,your%20direct%20line%20of%20sight.
has icd10 code: H35.3
code billability: Non-billable
has ICD10 name: Degeneration of macula and posterior pole

retinal disorders in diseases classified elsewhere
type: Class
subclass of: disorders of choroid and retina (NEW)
definition: damage in the eyes due to diabetes
definition editor: Virginia He, Justin Song
definition source: https://icd.codes/icd10cm/H36
has icd10 code: H36.0
code billability: Billable
has ICD10 name: Retinal disorders in diseases classified elsewhere

unspecified glaucoma
type: Class
subclass of: glaucoma (NEW)
definition: A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H40-H42/H40-/H40.9
has icd10 code: H40.9
code billability: Billable
has ICD10 name: Unspecified glaucoma

disorders of the skin and subcutaneous tissue
type: Class
subclass of: disease process
definition: Diseases and conditions affecting the skin and subcutaneous tissue
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99
has icd10 code: L80-L99
has ICD10 name: Other disorders of the skin and subcutaneous tissue

pressure ulcer of back
type: Class
subclass of: pressure ulcer
definition: are injuries to skin and underlying tissue resulting from prolonged pressure on the skinv
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone.
has icd10 code: L89.1
code billability: Non-billable
has ICD10 name: Pressure ulcer of back

non-pressure chronic ulcer of lower limb, not elsewhere classified
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition: a defect in the skin below the level of knee persisting for more than six weeks and shows no tendency to heal after three or more months.
definition editor: Virginia He
definition source: https://www.hindawi.com/journals/ulcers/2013/413604/
has icd10 code: L97
code billability: Non-billable
has ICD10 name: Pressure ulcer of back

disease (process) of the musculoskeletal system and connective tissue
type: Class
subclass of: disease process
definition: Diseases and conditions affecting the muskoskeletal system and connective tissue
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/M00-M99
has icd10 code: M00-M99
has ICD10 name: Diseases of the musculoskeletal system and connective tissue

low back pain DP
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Acute or chronic pain in the lumbar or sacral regions
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54.5
has icd10 code: M54.5
code billability: Billable
has ICD10 name: Low back pain

other specified disorders of muscle
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Muscle disorders that cause weakness, pain or even paralysis
definition editor: Virginia He
definition source: https://medlineplus.gov/muscledisorders.html
has icd10 code: M62.89
code billability: Billable
has ICD10 name: Other specified disorders of muscle

myalgia DP
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M70-M79/M79-/M79.1
has icd10 code: M79.1
code billability: Non-billable
has ICD10 name: Myalgia

myalgia, unspecified site DP
type: Class
subclass of: myalgia DP
definition: muscle aches and pain, which can involve ligaments, tendons and fascia, the soft tissues that connect muscles, bones and organs
definition editor: Virginia He, Justin Song
definition source: https://www.hopkinsmedicine.org/health/conditions-and-diseases/myalgia
has icd10 code: M79.10
code billability: Billable
has ICD10 name: Myalgia, unspecified site

age-related osteoporosis with current pathological fracture
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Osteoporosis is the most common bone disease and is caused by the thinning of the bones
definition editor: Virginia He, Justin Song
definition source: https://www.clearcareonline.com/blog/managing-a-homecare-agency/bone-diseases-in-the-elderly/#:~:text=Osteoporosis%20is%20the%20most%20common,a%20senior%20factures%20a%20bone.
has icd10 code: M80.0
code billability: Non-billable
has ICD10 name: Age-related osteoporosis with current pathological fracture

severe acute respiratory syndrome, unspecified
type: Class
subclass of: other diseases of the respiratory system
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: a viral respiratory illness caused by a coronavirus called SARS-associated coronavirus (SARS-CoV).
definition editor: Virginia He, Justin Song
definition source: https://www.cdc.gov/sars/index.html
has icd10 code: U04.9
has ICD10 name: Severe acute respiratory syndrome, unspecified

mixed asthma DP
type: Class
subclass of: asthma
definition: when you have symptoms of both asthma and chronic obstructive pulmonary disease
definition editor: Virginia He
definition source: https://www.webmd.com/lung/copd/asthma-copd-overlap
has icd10 code: J45.8
has ICD10 name: Mixed asthma

injury, poisoning and certain other consequences of external causes
type: Class
subclass of: disease process
definition: injury/other consequences caused by external sources
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88
has icd10 code: S00-T88
has ICD10 name: Injury, poisoning and certain other consequences of external causes

concussion DP
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: A violent jar or shock, or the condition which results from such an injury.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S06/S06.0-/S06.0
has icd10 code: S06.0
has ICD10 name: Concussion

fracture of head and neck of femur DP
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.0-/S72.0
has icd10 code: S72.0
has ICD10 name: Fracture of head and neck of femur

complications of procedures
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: there is a need for specific instruction for the patient
definition editor: Virginia He, Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81
has icd10 code: T81.0
has ICD10 name: Complications of procedures, not elsewhere classified

slipping, tripping, stumbling and falls
type: Class
subclass of: disease process
definition: an event which results in a person coming to rest inadvertently on the ground or floor or other lower level
definition editor: Virginia He
definition source: https://www.who.int/news-room/fact-sheets/detail/falls
has icd10 code: W00-W19
has ICD10 name: Slipping, tripping, stumbling and falls

unspecified fall
type: Class
subclass of: slipping, tripping, stumbling and falls
definition: an event which results in a person coming to rest inadvertently on the ground or floor or other lower level
definition editor: Virginia He
definition source: https://www.who.int/news-room/fact-sheets/detail/falls
has icd10 code: W19
has ICD10 name: Unspecified fall

alcoholic cirrhosis DP of liver
type: Class
subclass of: disease (process) of the liver
definition: liver failure
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.0
has icd10 code: K70.3
code billability: Non-billable
has ICD10 name: Alcoholic cirrhosis of liver

pressure ulcer
type: Class
subclass of: other disorders of the skin and subcutaneous tissue (NEW)
definition: An ulceration caused by prolonged pressure on the skin and tissues when one stays in one position for a long period of time, such as lying in bed.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89
has icd10 code: L89
code billability: Non-billable
has ICD10 name: Pressure ulcer

traumatic ischemia DP of muscle
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: A type of permanent damage to muscles and nerves that results from prolonged lack blood flow to those tissues. It is characterized by shortening and stiffening of the muscles.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T79-T79/T79-/T79.6
has icd10 code: T79.6
has ICD10 name: Traumatic ischemia of muscle

primary multidrug resistant tuberculosis
type: Class
subclass of: immune system DP
definition editor: Virginia He
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460787/#:~:text=without%20HIV%20infection.-,Introduction,MDR%2DTB%5B2%5D.
definition source: tuberculous infection caused by resistance to at least isoniazid and rifampin, the two most potent TB drugs.
has icd10 code: U50.00
has ICD10 name: Primary multidrug resistant tuberculosis

fall from one level to another
type: Class
subclass of: slipping, tripping, stumbling and falls
definition: to descend freely by the force of gravity
definition editor: Virginia He
definition source: https://www.merriam-webster.com/dictionary/fall
has icd10 code: W17
code billability: Non-billable
has ICD10 name: Other fall from one level to another

symptoms, signs and abnormal clinical and laboratory findings
type: Class
subclass of: disease process
definition: symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99
has icd10 code: R00-R99
has ICD10 name: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

hematuria DP
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: A disorder characterized by laboratory test results that indicate blood in the urine.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R30-R39/R31-/R31
has icd10 code: R31
code billability: Non-billable
has ICD10 name: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

anosmia DP
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: Loss of sense of smell
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R43-/R43.0
has icd10 code: R43.0
code billability: Billable
has ICD10 name: Anosmia

severe sepsis DP without septic shock
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: Sepsis associated with organ dysfunction distant from the site of infection.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R65-/R65.20
has icd10 code: R65.20
code billability: Billable
has ICD10 name: Severe sepsis without septic shock

factors influencing health status and contact with health services
type: Class
subclass of: disease process
definition: Persons encountering health services for examinations, Genetic carrier and genetic susceptibility to disease, Resistance to antimicrobial drugs, etc
definition editor: Virginia He
definition source: https://coder.aapc.com/icd-10-codes-range/298#:~:text=ICD%2D10%20Code%20range%20(Z00,receptor%20status%2C%20Retained%20foreign%20body
has icd10 code: Z00-Z99
has ICD10 name: Factors influencing health status and contact with health services

encounter for general adult medical examination
type: Class
subclass of: factors influencing health status and contact with health services
definition: Encounter for general adult medical examination
definition editor: Non-billable
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z00-/Z00.0
has icd10 code: Z00.0
has ICD10 name: Encounter for general adult medical examination

encounter for therapeutic drug level monitoring
type: Class
subclass of: factors influencing health status and contact with health services
definition: a procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor.
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z51-/Z51.81
has icd10 code: Z51.81
code billability: Billable
has ICD10 name: Encounter for therapeutic drug level monitoring

problem related to social environment
type: Class
subclass of: factors influencing health status and contact with health services
definition: Problem related to social environment
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z60-/Z60.9
has icd10 code: Z60.9
code billability: Billable
has ICD10 name: Problem related to social environment, unspecified

long term (current) use of aspirin
type: Class
subclass of: factors influencing health status and contact with health services
definition: long term use of asipirin
definition editor: Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z79-/Z79.82
has icd10 code: Z79.82
code billability: Billable
has ICD10 name: Long term (current) use of aspirin

allergy status to other antibiotic agents status
type: Class
subclass of: factors influencing health status and contact with health services
definition: when immune system reacts to a foreign substance or food that doesn't cause a reaction in most people
definition editor: Virginia He
definition source: https://www.mayoclinic.org/diseases-conditions/allergies/symptoms-causes/syc-20351497#:~:text=Allergies%20occur%20when%20your%20immune,produces%20substances%20known%20as%20antibodies.
has icd10 code: Z88.1
code billability: Billable
has ICD10 name: Allergy status to other antibiotic agents status

glomerular disorders
type: Class
subclass of: disease (process) of the genitourinary system
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: inflammation of the glomeruli, which are structures in your kidneys that are made up of tiny blood vessels. These knots of vessels help filter your blood and remove excess fluids. If your glomeruli are damaged, your kidneys will stop working properly, and you can go into kidney failure
definition editor: Virginia He
definition source: https://icd.codes/icd10cm/N08#:~:text=N08%20is%20a%20billable%20ICD,to%20specify%20a%20medical%20diagnosis.
has icd10 code: N08.3
has ICD10 name: glomerular disorders in diseases classified elsewhere

middle ear or mastoid DP
type: Class
subclass of: ear or mastoid disease process
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75
has icd10 code: H65-H75
has ICD10 name: Diseases of middle ear and mastoid

inner ear DP
type: Class
subclass of: ear or mastoid disease process
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H80-H83
has icd10 code: H80-H83
has ICD10 name: Diseases of inner ear

Intraoperative and postprocedural complications and disorders of ear and mastoid process, not elsewhere classified
type: Class
subclass of: interoperative and postprocedural ear and mastoid disease process
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H95-H95
has icd10 code: H95-H95
code billability: Not billable
has ICD10 name: Intraoperative and postprocedural complications and disorders of ear and mastoid process, not elsewhere classified

Conductive and sensorineural hearing loss
type: Class
subclass of: hearing loss
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75
has icd10 code: H65-H75
has ICD10 name: Diseases of middle ear and mastoid

hearing loss
type: Class
subclass of: ear or mastoid disease process
definition editor: Oliver He

Unspecified hearing loss, unspecified ear
type: Class
subclass of: hearing loss
definition editor: Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H90-H94/H91-/H91.90
has icd10 code: H91.90
code billability: Billable
has ICD10 name: Unspecified hearing loss, unspecified ear

interoperative and postprocedural ear and mastoid disease process
type: Class
subclass of: ear or mastoid disease process
definition editor: Oliver He

dementia in Alzheimer’s disease, atypical or mixed type
type: Class
subclass of: alzheimer's disease process
definition: Loss of memory, language, problem-solving and other thinking abilities in an Alzheimer's patient
definition editor: Grace Whah
definition source: https://www.alz.org/alzheimers-dementia/what-is-dementia#:~:text=Dementia%20is%20a%20general%20term,most%20common%20cause%20of%20dementia.
has icd10 code: F00.2
source: https://icd.who.int/browse10/2014/en#!/F00-F09

chondritis or perichondritis of external ear
type: Class
subclass of: external ear DP
definition editor: Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H60-H62/H61-/H61.0
has icd10 code: H61.0
has ICD10 name: Chondritis and perichondritis of external ear

Nonsuppurative otitis media DP
type: Class
subclass of: middle ear or mastoid DP
subclass of: Restriction
  on property: occurs in
  some values from: middle ear
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: acute
subclass of: Restriction
  on property: has DP material quality
  some values from: nonsuppurative
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
definition editor: Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65
has icd10 code: H65
code billability: Non-Billable
has ICD10 name: Nonsuppurative otitis media

hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
type: Class
subclass of: chronic kidney disease DP
definition: Hypertension (Elevated blood pressure) in patients with stage 5 kidney disease or end stage renal disease
definition editor: Grace Whah
definition source: https://www.webmd.com/hypertension-high-blood-pressure/guide/what-is-renal-hypertension#:~:text=Renal%20hypertension%2C%20also%20called%20renovascular,blood%20vessels%20of%20the%20kidney.
has icd10 code: I12.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I12-/I12.0

pulmonary embolism with acute cor pulmonale
type: Class
subclass of: pulmonary heart DP and disease processes of pulmonary circulation
definition: Presence of a blockage in one of the pulmonary arteries in the lungs in patients with acute cor pulmonale (acute right heart failure)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pulmonary-embolism/symptoms-causes/syc-20354647#:~:text=Pulmonary%20embolism%20is%20a%20blockage,body%20(deep%20vein%20thrombosis).
has icd10 code: I26.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I26-I28/I26-/I26.0

nonrheumatic mitral (valve) insufficiency
type: Class
subclass of: disease (process) of the circulatory system
definition: Backflow of blood from the left ventricle into the left atrium due to imperfect closure of the mitral valve
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I34-/I34.0
has icd10 code: I34.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I34-/I34.0

acute upper respiratory infections of multiple sites
type: Class
subclass of: *Acute upper respiratory infections of multiple and unspecified sites
definition: upper respiratory system is infected in multiple sites and parts will become inflamed or damaged.
definition editor: Grace Whah
definition source: https://www.healthline.com/health/acute-upper-respiratory-infection#:~:text=An%20acute%20URI%20is%20a,pharyngitis%2C%20epiglottitis%2C%20and%20tracheobronchitis.
has icd10 code: J06.8
source: https://icd.who.int/browse10/2010/en#!J06.8

pneumonia due to Klebsiella pneumoniae
type: Class
subclass of: bacterial pneumonia
definition: Pneumonia (infection that inflames the air sacs in the lungs) caused by Klebsiella pneumoniae bacteria
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has icd10 code: J15.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.0

pneumonia due to Pseudomonas
type: Class
subclass of: bacterial pneumonia
definition: Pneumonia (infection that inflames the air sacs in the lungs) caused by Pseudomonas bacteria
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has icd10 code: J15.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.1

emphysema, unspecified
type: Class
subclass of: chronic lower respiratory diseases
definition: A condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.9
has icd10 code: J43.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.9

pressure ulcer of elbow
type: Class
subclass of: pressure ulcer
definition: Injury to elbow skin and underlying tissue resulting from prolonged pressure on skin around elbow
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone.
has icd10 code: L89.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.0

pre-existing type 2 diabetes mellitus, in pregnancy, childbirth and the puerperium
type: Class
subclass of: other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
definition: The existence of type 2 diabetes mellitus in pregnant patients or patients who had a child within the last 6 weeks
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.1
has icd10 code: O24.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.1

localized enlarged lymph nodes
type: Class
subclass of: disease processes of veins, lymphatic vessels and lymph nodes
definition: Lymph nodes in one particular area of the body swell up
definition editor: Grace Whah
definition source: https://www.medicalnewstoday.com/articles/324105#causes
has icd10 code: R59.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R59-/R59.0

epistaxis
type: Class
subclass of: other diseases of the respiratory system
definition: A disorder characterized by bleeding from the nose
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04.0
has icd10 code: R04.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04.0

ascites
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
subclass of: disease (process) of esophagus, stomach and duodenum
definition: Abnormal buildup of fluid in the abdomen
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R18-/R18
has icd10 code: R18
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R18-/R18

unattended death
type: Class
subclass of: disease process
definition: Death in circumstances where the body of the deceased was found and no cause could be discovered
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2010/en#!R98
has icd10 code: R98
source: https://icd.who.int/browse10/2010/en#!R98

infection following a procedure
type: Class
subclass of: complications of procedures
definition: Infection in the body found after a procedure
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.4
has icd10 code: T81.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.4

presence of urogenital implants
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: Presence of implant into the urethra to help control urine leakage (foley catheter, ureteral stent, pessary, etc).
definition editor: Grace Whah
definition source: https://medlineplus.gov/ency/article/007373.htm
has icd10 code: Z96.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.0

presence of other bone and tendon implants
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: Has bone/tendon implants in body
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.7
has icd10 code: Z96.7
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.7

chronic viral hepatitis C
type: Class
subclass of: disease (process) of the liver
definition: Inflammation of the liver caused by hepatitis c virus lasting six months or more
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.2
has icd10 code: B18.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.2

candidal stomatitis
type: Class
subclass of: disease (process) of esophagus, stomach and duodenum
definition: Infection of the mucous membranes of the mouth by a fungus of the genus candida
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37.0
has icd10 code: B37.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37.0

secondary malignant neoplasm of lung
type: Class
subclass of: neoplasm DP
definition: Cancer that has spread from the original tumor to the lung
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.0
has icd10 code: C78.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.0

iron deficiency anemia secondary to blood loss (chronic)
type: Class
subclass of: iron deficiency anemia DP
definition: Iron deficiency anemia (a condition in which blood lacks adequate healthy blood cells) caused by chronic blood loss
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/iron-deficiency-anemia/symptoms-causes/syc-20355034
has icd10 code: D50.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D50-D53/D50-/D50.0

type 1 diabetes mellitus with ketoacidosis
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: The prescense of diabetic ketoacidosis (body produces high levels of ketones and not enough insulin) in type 1 diabetic patients
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551#:~:text=Diabetic%20ketoacidosis%20is%20a%20serious,can't%20produce%20enough%20insulin.
has icd10 code: E10.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.1

other obesity
type: Class
subclass of: overweight, obesity and other hyperalimentation (NEW)
subclass of: overweight and obesity
definition: Overweight and obesity caused by miscellaneous disorders
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.8
has icd10 code: E66.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.8

other dilirum
type: Class
subclass of: disease (process) of the nervous system
definition: Delirium of mixed origin, postoperative delirium
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2010/en#/F05.8
has icd10 code: F05.8
source: https://icd.who.int/browse10/2010/en#/F05.8

delirium, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: An abrupt change in the brain that causes mental confusion and emotional disruption with unspecified cause
definition editor: Grace Whah
definition source: https://www.healthline.com/health/delirium#:~:text=Delirium%20is%20an%20abrupt%20change,after%20surgery%2C%20or%20with%20dementia.
has icd10 code: F05.9
source: https://icd.who.int/browse10/2010/en#/F05.9

other personality and behavioral disorders due to known physiological condition
type: Class
subclass of: mental disease processes
definition: Personality/behavioral disorders caused by physiological disorder
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F07-/F07.8
has icd10 code: F07.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F07-/F07.8

schizophrenia, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: A mental disorder in which a person has trouble telling the difference between real and unreal experiences, thinking logically, and behaving normally in social situations.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F20-/F20.9
has icd10 code: F20.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F20-/F20.9

multiple sclerosis
type: Class
subclass of: disease (process) of the nervous system
definition: A disorder of the nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G35-G37/G35-/G35
has icd10 code: G35
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G35-G37/G35-/G35

hemiplegia, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: Paralysis of one side of the body with unspecified cause
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.9
has icd10 code: G81.9
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.9

pneumonia due to Escherichia coli
type: Class
subclass of: bacterial pneumonia
definition: An infection that inflames the air sacs in one or both lungs caused by Escherichia coli bacteria
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has icd10 code: J15.5
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.5

nonallergic asthma
type: Class
subclass of: asthma
definition: Nonallergic asthma (a condition in which your airways narrow and swell)
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/J45.1
has icd10 code: J45.1
source: https://icd.who.int/browse10/2016/en#/J45.1

mild intermittent asthma, uncomplicated
type: Class
subclass of: asthma
definition: Asthma symptoms (airway swelling) occuring fewer than three times a week
definition editor: Grace Whah
definition source: https://www.webmd.com/asthma/qa/what-is-mild-intermittent-asthma#:~:text=ANSWER,age%2C%20sex%2C%20and%20height.
has icd10 code: J45.20
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J45-/J45.20

other and unspecified cirrhosis of liver
type: Class
subclass of: disease (process) of the liver
definition: Unspecified late stage scarring of the liver
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/cirrhosis/symptoms-causes/syc-20351487
has icd10 code: K74.6
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K74-/K74.6

sicca syndrome [Sjögren]
type: Class
subclass of: inflammation DP
definition: A chronic inflammation of the tear and salivary glands, often accompanied by rheumatoid arthritis and the presence of autoantibodies in the blood
definition editor: Grace Whah
alternative term: Sjogren syndrome
definition source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M30-M36/M35-/M35.0
has icd10 code: M35.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M30-M36/M35-/M35.0

muscle wasting and atrophy, not elsewhere classified, unspecified site
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Wasting or thinning of muscle tissue
definition editor: Grace Whah
definition source: https://www.healthline.com/health/muscle-atrophy#:~:text=Muscle%20atrophy%20is%20when%20muscles,can%20result%20in%20muscle%20wasting.
has icd10 code: M62.50
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M60-M63/M62-/M62.50

other congenital malformations of tongue
type: Class
subclass of: other congenital malformations of the digestive system (NEW)
definition: Genetic malformation of the tongue
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45/Q38-/Q38.3
has icd10 code: Q38.3
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45/Q38-/Q38.3

other chest pain
type: Class
subclass of: chest pain
definition: Unspecified anterior chest-wall pain
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/R07.3
has icd10 code: R07.3
source: https://icd.who.int/browse10/2016/en#/R07.3

unspecified trochanteric fracture of femur
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Unspecified fracture of the proximal femur between the cervical region and the shaft
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/science/article/pii/S1877056813002740#:~:text=Definition,in%20the%20definition%20%5B6%5D.
has icd10 code: S72.10
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.1-/S72.10

encounter for prophylactic immunotherapy
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Administration of immunotherapy
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/Z29.1
has icd10 code: Z29.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z29-/Z29.1

inadequate family support
type: Class
subclass of: need for assistance with personal care
definition: Lack of familial support
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/Z63.2
has icd10 code: Z63.2
source: https://icd.who.int/browse10/2016/en#/Z63.2

need for continuous supervision
type: Class
subclass of: need for assistance with personal care
definition: Continous supervision needed, problems related to care provider dependency
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.3
has icd10 code: Z74.3
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.3

personal history of irradiation
type: Class
subclass of: personal status and history
definition: Personal history of exposure to radiation
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.3
has icd10 code: Z92.3
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.3

presence of prosthetic heart valve
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: Patient has prosthetic heart valve
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.2
has icd10 code: Z95.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.2

exposure to SARS-associated coronavirus
type: Class
subclass of: contact with and (suspected) exposure to other communicable diseases
definition: Patient was exposed to SARS-associated coronavirus
definition editor: Grace Whah
definition source: http://www.icd9data.com/2015/Volume1/V01-V91/V01-V09/V01/V01.82.htm
has icd9 code: V01.82
code billability: Billable
source: http://www.icd9data.com/2015/Volume1/V01-V91/V01-V09/V01/V01.82.htm

Staphylococcus aureus as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: Diseases in body caused by Staphylococcus aureus bacteria
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.6
has icd10 code: B95.6
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.6

secondary malignant neoplasm of pleura
type: Class
subclass of: neoplasm DP
definition: Secondary abnormal growth of cells in the pleural space (the cavity between the lungs and chest wall that contains pleural fluid)
definition editor: Grace Whah
definition source: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=22&contentid=pleuraltumors#:~:text=Pleural%20tumors%20are%20found%20in,and%20difficult%20to%20operate%20on.
has icd10 code: C78.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.2

sarcoidosis of other sites
type: Class
subclass of: inflammation DP
definition: A disease characterized by the growth of tiny collections of inflammatory cells (granulomas) in any part of your body
definition source: https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358#:~:text=Sarcoidosis%20is%20a%20disease%20characterized,skin%2C%20heart%20and%20other%20organs.
has icd10 code: D86.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.8

other and unspecified adrenocortical insufficiency
type: Class
subclass of: disorders of other endocrine glands (NEW)
subclass of: disease processes of the blood stream
definition: An unspecified condition in which the adrenal glands do not produce adequate amounts of steroid hormones (cortisol)
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Adrenal_insufficiency#:~:text=Adrenal%20insufficiency%20is%20a%20condition,potassium%20secretion%2C%20and%20water%20retention.
has icd10 code: E27.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E20-E35/E27-/E27.4

unspecified protein-calorie malnutrition
type: Class
subclass of: malnutrition (NEW)
subclass of: disease processes of the blood stream
definition: A condition caused by not getting enough calories or the right amount of key nutrients, such as vitamins and minerals, that are needed for health.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E46-/E46
has icd10 code: E46
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E46-/E46

deficiency of other specified B group vitamins
type: Class
subclass of: other nutritional deficiencies (NEW)
subclass of: disease processes of the blood stream
definition: A nutritional condition produced by a deficiency of B group vitamins (folic acid, B-12) in the diet
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E53-/E53.8
has icd10 code: E53.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E53-/E53.8

disorders of phosphorus metabolism and phosphatases
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: Disorders in the processing, absorption, transport, storage, and utilization of phosphorus in the body
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.3
has icd10 code: E83.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.3

dementia in Alzheimer disease, unspecified
type: Class
subclass of: alzheimer's disease process
definition: Unspecified loss of memory, language,and other thinking abilities in a patient with Alzheimer's
definition editor: Grace Whah
definition source: https://www.alz.org/alzheimers-dementia/what-is-dementia#:~:text=Dementia%20is%20a%20general%20term,most%20common%20cause%20of%20dementia.
has icd10 code: F00.9
source: https://icd.who.int/browse10/2016/en#/F00.9

major depressive disorder, single episode, moderate
type: Class
subclass of: mood disorder due to known physiological condition
definition: Single major depressive disorder episode (a depressed mood for two weeks or more)
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Major_depressive_episode
has icd10 code: F32.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.1

major depressive disorder, recurrent, unspecified
type: Class
subclass of: mood disorder due to known physiological condition
definition: Recurrent major depressive disorder episodes (a depressed mood for two weeks or more)
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Major_depressive_episode
has icd10 code: F33.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F33-/F33.9

transient cerebral ischemic attack, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: A brief stroke (from a few minutes to an hour) of cerebral dysfunction when the blood supply to this part of the brain is blocked
definition editor: Grace Whah
definition source: https://medlineplus.gov/transientischemicattack.html#:~:text=A%20transient%20ischemic%20attack%20(TIA,one%20side%20of%20the%20body
has icd10 code: G45.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G45-/G45.9

spastic hemiplegia
type: Class
subclass of: disease (process) of the nervous system
definition: A neuromuscular condition of spasticity that results in the muscles on one side of the body to be in a constant state of contraction
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Spastic_hemiplegia#:~:text=Spastic%20hemiplegia%20is%20a%20neuromuscular,impairment%20umbrella%20of%20cerebral%20palsy.
has icd10 code: G81.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.1

left ventricular failure, unspecified
type: Class
subclass of: heart failure DP
definition: Failure of adequate output by the left ventricle
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-/I50.1
has icd10 code: I50.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-/I50.1

cerebral atherosclerosis
type: Class
subclass of: disease (process) of the nervous system
definition: The result of thickening and hardening of the walls of the arteries in the brain
definition editor: Grace Whah
definition source: https://www.ninds.nih.gov/Disorders/All-Disorders/Cerebral-Arteriosclerosis-Information-Page#:~:text=Definition,can%20cause%20serious%20health%20problems.
has icd10 code: I67.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.2

parainfluenza virus pneumonia
type: Class
subclass of: influenza pneumonia
definition: An infection that inflames the air sacs in one or both lungs caused by Parainfluenza virus
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has icd10 code: J12.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J12-/J12.2

respiratory infection, not elsewhere classified
type: Class
subclass of: respiratory infections (NEW)
definition: Respiratory tract infections not specified as acute, chronic, lower, or upper
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2019/en#/J98.7
has icd10 code: J98.7
source: https://icd.who.int/browse10/2019/en#/J98.7

pressure ulcer of hip
type: Class
subclass of: pressure ulcer
definition: Injury to hip skin and underlying tissue resulting from prolonged pressure on skin around hip
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone.
has icd10 code: L89.2
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.2

polyosteoarthritis, unspecified
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: When water content of the body cartilage increases and the protein makeup of cartilage degenerates
definition editor: Grace Whah
definition source: https://www.novusbio.com/diseases/polyosteoarthritis-unspecified#:~:text=Polyosteoarthritis%20is%20related%20to%20the,and%20eventually%20cartilage%20will%20degenerate.
has icd10 code: M15.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M15-M19/M15-/M15.9

irritability and anger
type: Class
subclass of: general symptoms
definition: The feeling of being anger or irritated
definition editor: Grace Whah
definition source: https://www.merriam-webster.com/dictionary/irritable
has icd10 code: R45.4
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R45-/R45.4

dysarthria and anarthria
type: Class
subclass of: disease (process) of the nervous system
definition: Anarthria is a severe form of dysarthria. Dysarthria is a motor speech disorder that occurs when someone can't coordinate or control the muscles used for speaking.
definition editor: Grace Whah
definition source: https://www.healthline.com/health/anarthria#:~:text=Anarthria%20is%20a%20severe%20form,t%20articulate%20speech%20at%20all.
has icd10 code: R47.4
code billability: Billable
source: https://www.icd10data.com/search

abnormal weight loss
type: Class
subclass of: general signs
definition: Uncommon severe weight loss for an unspecified cause
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.4
has icd10 code: R63.4
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.4

nonadministration of surgical and medical care
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: This describes the circumstance causing an injury, not the nature of the injury. The injury in this case is caused by the lack of administration of surgical or medical care.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/V00-Y99/Y62-Y69/Y66-/Y66
has icd10 code: Y66
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/V00-Y99/Y62-Y69/Y66-/Y66

anemia in neoplastic disease
type: Class
subclass of: disease processes of the blood stream
definition: Anemia (a condition in which you lack enough healthy red blood cells to carry adequate oxygen to your body's tissues) in patients with neoplasm (tumors)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360#:~:text=Anemia%20is%20a%20condition%20in,range%20from%20mild%20to%20severe.
has icd10 code: D63.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D63-/D63.0

encounter for screening for other viral diseases
type: Class
subclass of: encounter for screening, unspecified
definition: Patient had a viral disease screening done
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z11-/Z11.5
has icd10 code: Z11.5
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z11-/Z11.5

carrier of other specified bacterial diseases
type: Class
subclass of: factors influencing health status and contact with health services
definition: Patient had specificed bacterial disease / infectious disease
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z22-/Z22.3
has icd10 code: Z22.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z22-/Z22.3

encounter for adjustment and management of other implanted devices
type: Class
subclass of: encounter for other specified aftercare
definition: Patient had implanted devices managed and adjusted
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z45-/Z45.8
has icd10 code: Z45.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z45-/Z45.8

procedure and treatment not carried out because of patient's decision for other and unspecified reasons
type: Class
subclass of: factors influencing health status and contact with health services
definition: Patient did not undergo treatment due to patients decision
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z53-/Z53.2
has icd10 code: Z53.2
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z53-/Z53.2

chronic viral hepatitis B without delta-agent
type: Class
subclass of: disease (process) of the liver
definition: Inflammation of the liver in humans caused by hepatitis b virus lasting six months or more.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.1
has icd10 code: B18.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.1

sequelae of respiratory and unspecified tuberculosis
type: Class
subclass of: other diseases of the respiratory system
definition: The aftereffect of respiratory disease and tuberculosis
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B90-B94/B90-/B90.9
has icd10 code: B90.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B90-B94/B90-/B90.9

Enterococcus as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: Diseases in the body caused by enterococcus genus
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.2
has icd10 code: B95.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.2

Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: Diseases in the body caused by Klebsiella pneumoniae bacteria
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.1
has icd10 code: B96.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.1

malignant neoplasm of colon, unspecified
type: Class
subclass of: neoplasm DP
definition: Primary cancerous tumor of the colon
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C18-/C18.9
has icd10 code: C18.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C18-/C18.9

liver cell carcinoma
type: Class
subclass of: disease (process) of the liver
definition: Carcinoma (cancerous tumor) of the liver
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.0
has icd10 code: C22.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.0

other viral enteritis
type: Class
subclass of: other diseases of the digestive system (NEW)
definition: A stomach bug or stomach flu
definition editor: Grace Whah
definition source: https://www.healthgrades.com/right-care/digestive-health/enteritis#:~:text=Most%20people%20call%20viral%20enteritis,Parasites%20include%20Giardia%20and%20Cryptosporidium.
has icd10 code: A08.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A08-/A08.3

sepsis due to Staphylococcus aureus
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: Sepsis (when the body's response to an infection is out of balance) caused by a staph infection. Could lead to organ damage or failure
definition source: https://www.sciencedaily.com/releases/2018/07/180726162039.htm#:~:text=For%20patients%20diagnosed%20with%20a,the%20people%20who%20develop%20it.
has icd10 code: A41.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A41-/A41.0

other specified acute viral hepatitis
type: Class
subclass of: disease (process) of the liver
definition: Hepatitis (not hepatitis A or hepatitis B); inflammation of the liver
definition editor: Grace Whah
definition source: https://www.cdc.gov/hepatitis/abc/index.htm#:~:text=Hepatitis%20means%20inflammation%20of%20the,medical%20conditions%20can%20cause%20hepatitis.
has icd10 code: B17.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B17-/B17.8

other viral agents as the cause of diseases classified elsewhere
type: Class
subclass of: viral agents as the cause of diseases
definition: Diseases caused by other viral agents
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.8
has icd10 code: B97.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.8

intrahepatic bile duct carcionoma
type: Class
subclass of: neoplasm DP
subclass of: disease (process) of gallbladder, biliary tract and pancreas
definition: Tumor of the connective tissues of the bile ducts
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.1
has icd10 code: C22.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.1

malignant neoplasm of upper lobe, bronchus or lung
type: Class
subclass of: neoplasm DP
definition: Cancerous tumor of a respiratory organ (upper lobe, bronchus, or lung)
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C30-C39/C34-/C34.1
has icd10 code: C34.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C30-C39/C34-/C34.1

malignant neoplasm of endometrium
type: Class
subclass of: neoplasm DP
definition: Cancer of the endometrium
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C51-C58/C54-/C54.1
has icd10 code: C54.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C51-C58/C54-/C54.1

sarcoidosis of lung
type: Class
subclass of: other diseases of the respiratory system
definition: A lung disease characterized by the growth of inflammatory cells (granulomas) in the lungs
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358
has icd10 code: D86.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.0

sarcoidosis, unspecified
type: Class
subclass of: inflammation DP
definition: A disease characterized by the growth of inflammatory cells (granulomas) in a specific part of your body (most commonly liver, lungs, skin, and lymph nodes)
definition source: https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358
has icd10 code: D86.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.9

polyclonal hypergammaglobulinemia
type: Class
subclass of: disease processes of the blood stream
definition: An uncommon condition characterized by elevated levels of immunoglobulins in your blood
definition editor: Grace Whah
alternative term: PHGG
definition source: https://www.healthline.com/health/hypergammaglobulinemia
has icd10 code: D89.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D89-/D89.0

thyrotoxicosis with diffuse goiter
type: Class
subclass of: disorders of thyroid gland (NEW)
subclass of: disease processes of the blood stream
definition: A common form of hyperthyroidism affecting the entire thyroid gland and causing the gland to become enlarged
definition editor: Grace Whah
alternative term: Graves' disease
definition source: https://www.virginiamason.org/thyrotoxicosis#:~:text=As%20many%20as%2070%2D80,gland%20becomes%20enlarged%20(goiter).
has icd10 code: E05.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07/E05-/E05.0

type 1 diabetes mellitus with ketoacidosis with coma
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: The prescense of diabetic ketoacidosis (body produces high levels of ketones and not enough insulin) in type 1 diabetic patients, resulting in a coma
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551#:~:text=Diabetic%20ketoacidosis%20is%20a%20serious,can't%20produce%20enough%20insulin.
has icd10 code: E10.11
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.11

type 1 diabetes mellitus with unspecified complications
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: Type 1 diabetes (body cannot break down sugars very easily) with unspecified complications
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.8
has icd10 code: E10.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.8

type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema
type: Class
subclass of: disease processes of the blood stream
definition: Type 2 diabetes with diabetic macular edema (when blood vessels in the eye retina leak fluid, causing swelling in the macula)
definition editor: Grace Whah
definition source: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy#:~:text=Diabetic%20retinopathy%20can%20lead%20to,a%20part%20of%20the%20retina).
has icd10 code: E11.311
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.311

type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema
type: Class
subclass of: disease processes of the blood stream
definition: Type 2 diabetes with diabetic retinopathy (vision loss and blindness) without macular edema (swelling in the macula cause by fluid leaking from the retina)
definition editor: Grace Whah
definition source: https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy#:~:text=Diabetic%20retinopathy%20can%20lead%20to,a%20part%20of%20the%20retina).
has icd10 code: E11.319
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.319

type 2 diabetes mellitus with diabetic cataract
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: Cataracts (cloudy area in the lens of your eye) caused by type 2 diabetes
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.36
has icd10 code: E11.36
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.36

type 2 diabetes mellitus with other diabetic ophthalmic complication
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: Other eye diseases caused by type 2 diabetes
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.39
has icd10 code: E11.39
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.39

mixed disorder of acid-base balance
type: Class
subclass of: disease processes of the blood stream
definition: The coexistences of 2 or more primary acid-base disorders in the same patient
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/science/article/abs/pii/S0195561689500329#:~:text=A%20mixed%20acid%2Dbase%20disorder,and%20chemistries%2C%20and%20anion%20gap.
has icd10 code: E87.4
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.4

postprocedural hypothyroidism
type: Class
subclass of: complications of procedures
definition: Development of hypothyroidism (when the thyroid gland doesn't produce enough of crucial hormones) following surgery
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/hypothyroidism/symptoms-causes/syc-20350284
has icd10 code: E89.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E89-E89/E89-/E89.0

multi-infarct dementia
type: Class
subclass of: disease (process) of the nervous system
definition: Dementia that is gradual in onset, following a number of transient ischaemic episodes which produce an accumulation of infarcts in the cerebral parenchyma
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/F01.1
has icd10 code: F01.1
source: https://icd.who.int/browse10/2016/en#/F01.1

other vascular dementia
type: Class
subclass of: disease (process) of the nervous system
definition: Other vascular dementia (problems with reasoning, planning, judgement, memory, and other thought processes caused by brain damage from impaired blood blow to your brain)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/vascular-dementia/symptoms-causes/syc-20378793#:~:text=Vascular%20dementia%20is%20a%20general,t%20always%20cause%20vascular%20dementia.
has icd10 code: F01.8
source: https://icd.who.int/browse10/2016/en#/F01.8

vascular dementia, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: Unspecified vascular dementia (problems with reasoning, planning, judgement, memory, and other thought processes caused by brain damage from impaired blood blow to your brain)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/vascular-dementia/symptoms-causes/syc-20378793#:~:text=Vascular%20dementia%20is%20a%20general,t%20always%20cause%20vascular%20dementia.
has icd10 code: F01.9
source: https://icd.who.int/browse10/2016/en#/F01.9

delusional disorder
type: Class
subclass of: mood disorder due to known physiological condition
definition: A disorder characterized by the development either of a single delusion or of a set of related delusions that are usually persistent and sometimes lifelong.
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/F22.0
has icd10 code: F22.0
source: https://icd.who.int/browse10/2016/en#/F22.0

unspecified psychosis not due to a substance or known physiological condition
type: Class
subclass of: mental disease processes
definition: A condition that affects the way your brain processes information and causes you to lose touch with reality. In this case, not caused by substance abuse or a known physiological condition
definition editor: Grace Whah
definition source: https://www.webmd.com/schizophrenia/guide/what-is-psychosis#1
has icd10 code: F29
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F29-/F29

major depressive disorder, single episode, mild
type: Class
subclass of: mood disorder due to known physiological condition
definition: Single episode of major depressive disorder (persistent feeling of sadness and loss of interest)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/depression/symptoms-causes/syc-20356007
has icd10 code: F32.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.0

post-traumatic stress disorder
type: Class
subclass of: generalized anxiety disorder
definition: A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.
definition editor: Grace Whah
alternative term: PTSD
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F43-/F43.1
has icd10 code: F43.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F43-/F43.1

other Alzheimer's disease
type: Class
subclass of: alzheimer's disease process
definition: Other form of Alzheimer's disease (diseases where dementia symptoms gradually worsen over time)
definition editor: Grace Whah
definition source: https://www.alz.org/alzheimers-dementia/what-is-alzheimers#:~:text=Alzheimer's%20is%20a%20progressive%20disease,and%20respond%20to%20their%20environment.
has icd10 code: G30.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30-/G30.8

localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
type: Class
subclass of: disease (process) of the nervous system
definition: Epilepsy with simple partial seizures and focal EEG abnoralities
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/topics/neuroscience/localization-related-epilepsy#:~:text=Benign%20focal%20epilepsies%20of%20childhood%20are%20idiopathic%20localization%E2%80%90related%20epilepsies,a%20tendency%20for%20spontaneous%20remission.
has icd10 code: G40.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.1

localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
type: Class
subclass of: disease (process) of the nervous system
definition: Epilepsy with complex partial seizures and focal EEG abnoralities
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/topics/neuroscience/localization-related-epilepsy#:~:text=Benign%20focal%20epilepsies%20of%20childhood%20are%20idiopathic%20localization%E2%80%90related%20epilepsies,a%20tendency%20for%20spontaneous%20remission.
has icd10 code: G40.2
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.2

myasthenia gravis
type: Class
subclass of: immune system DP
definition: A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness
definition editor: Grace Whah
alternative term: MG
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G70-G73/G70-/G70.0
has icd10 code: G70.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G70-G73/G70-/G70.0

age-related nuclear cataract
type: Class
subclass of: disorders of lens (NEW)
definition: Cataracts (cloudy area in the lens of your eye) in the center of the eye lens due to age
definition editor: Grace Whah
definition source: https://www.nvisioncenters.com/cataracts/types/#:~:text=Nuclear%20cataracts%20are%20often%20a,they%20often%20impact%20distance%20vision.
has icd10 code: H25.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H25-/H25.1

unspecified cataract
type: Class
subclass of: disorders of lens (NEW)
definition: Cataracts (cloudy area in the lens of your eye) caused by unspecified reason
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H26-/H26.9
has icd10 code: H26.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H26-/H26.9

visual field defects
type: Class
subclass of: visual disturbances and blindness (NEW)
definition: A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of eye diseases (e.g., retinal diseases and glaucoma); optic nerve diseases, and other conditions.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H53-/H53.4
has icd10 code: H53.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H53-/H53.4

blindness, one eye
type: Class
subclass of: visual disturbances and blindness (NEW)
definition: Cannot see out of one eye
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H54-/H54.4
has icd10 code: H54.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H54-/H54.4

non-ST elevation (NSTEMI) myocardial infarction
type: Class
subclass of: disease (process) of the circulatory system
definition: A heart attack in the absence of observable q wave abnormalities in the ecg.
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/heart-attack/symptoms-causes/syc-20373106
has icd10 code: I21.4
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I21-/I21.4

atherosclerotic heart disease of native coronary artery with angina pectoris
type: Class
subclass of: atherosclerosis DP
definition: A condition in which arteries become narrower and slow down the flow of blood accompanied with chest pain
definition editor: Grace Whah
definition source: https://www.ottawaheart.ca/heart-condition/coronary-artery-disease-atherosclerosis#:~:text=Coronary%20artery%20disease%20(CAD)%20is,down%20the%20flow%20of%20blood.
has icd10 code: I25.11
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I25-/I25.11

nontraumatic subarachnoid hemorrhage
type: Class
subclass of: disease (process) of the nervous system
definition: bleeding into the space between the surface of the brain, or pia mater, and the arachnoid, one of three coverings of the brain
definition editor: Grace Whah
alternative term: SAH
definition source: https://www.uclahealth.org/neurosurgery/subarachnoid-hemorrhage
has icd10 code: I60
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I60-/I60

nontraumatic intracerebral hemorrhage, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma.
definition editor: Grace Whah
definition source: https://emedicine.medscape.com/article/1163977-overview#:~:text=Nontraumatic%20intracerebral%20hemorrhage%20most%20commonly,cold%20exposure)%2C%20rupture%20of%20an
has icd10 code: I61.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I61-/I61.9

aortic aneurysm and dissection
type: Class
subclass of: disease (process) of the circulatory system
definition: A balloon-like buldge like causes a dissection (a tear in the lining of the aorta)
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/aortic-dissection/multimedia/aortic-dissection/img-20007636#:~:text=An%20aortic%20aneurysm%20occurs%20when,the%20image%20on%20the%20right.
has icd10 code: I71
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I70-I79/I71-/I71

influenza due to certain identified influenza viruses
type: Class
subclass of: influenza due to pathogen
definition: A contagious respiratory illness that can cause mild to severe illness (fever, chills, aches)
definition editor: Grace Whah
alternative term: Flu
definition source: https://www.cdc.gov/flu/about/index.html
has icd10 code: J09
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J09-/J09

pneumonia due to other specified infectious organisms
type: Class
subclass of: pneumonia due to pathogen
definition: infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing.
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has icd10 code: J16.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J16-/J16.8

acute bronchitis due to rhinovirus
type: Class
subclass of: other acute lower respiratory infections
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: contagious viral infection caused by rhinovirus that causes inflammation of the bronchial tubes
definition editor: Grace Whah
definition source: https://familydoctor.org/condition/acute-bronchitis/#:~:text=Acute%20bronchitis%20is%20a%20contagious,harder%20for%20you%20to%20breathe.
has icd10 code: J20.6
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20.6

unspecified chronic gastritis
type: Class
subclass of: disease (process) of esophagus, stomach and duodenum
definition: inflammation of the stomach lining
definition editor: Grace Whah
definition source: https://www.healthline.com/health/gastritis-chronic#:~:text=Chronic%20gastritis%20occurs%20when%20your,some%20of%20its%20protective%20cells.
has icd10 code: K29.5
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31/K29-/K29.5

diverticular disease of large intestine without perforation or abscess
type: Class
subclass of: other disease (process) of the intestines
definition: Diverticular disease consists of three conditions that involve the development of small sacs or pockets in the wall of the colon, including diverticulosis, diverticular bleeding, and diverticulitis.
definition editor: Grace Whah
definition source: https://www.webmd.com/digestive-disorders/diverticular-disease#1
has icd10 code: K57.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K57-/K57.3

other diseases of anus and rectum
type: Class
subclass of: other disease (process) of the intestines
definition: Disease of the anus or rectum
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K62-/K62
has icd10 code: K62
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K62-/K62

hepatic failure, unspecified
type: Class
subclass of: disease (process) of the liver
definition: A disorder characterized by the inability of the liver to metabolize chemicals in the body.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.9
has icd10 code: K72.9
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.9

Other specified inflammatory liver diseases
type: Class
subclass of: disease (process) of the liver
definition: Disease resulting in the inflammation of the liver
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K75-/K75.8
has icd10 code: K75.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K75-/K75.8

calculus of gallbladder without cholecystitis
type: Class
subclass of: disease (process) of gallbladder, biliary tract and pancreas
definition: Gallstones without inflammation of the gallbladder wall
definition editor: Grace Whah
definition source: https://nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73556/all/Cholecystitis_and_Cholelithiasis
has icd10 code: K80.2
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87/K80-/K80.2

obstruction of bile duct
type: Class
subclass of: disease (process) of gallbladder, biliary tract and pancreas
definition: a blockage in the tubes that carry bile from the liver to the gallbladder and small intestine.
definition editor: Grace Whah
definition source: https://www.mountsinai.org/health-library/diseases-conditions/bile-duct-obstruction#:~:text=Bile%20duct%20obstruction%20is%20a,into%20the%20duodenum%20for%20digestion.
has icd10 code: K83.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87/K83-/K83.1

gastrointestinal hemorrhage, unspecified
type: Class
subclass of: other diseases of the digestive system (NEW)
definition: Bleeding from the gastric wall.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.2
has icd10 code: K92.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.2

Psoriasis, unspecified
type: Class
subclass of: skin DP
definition: A chronic disease of the skin marked by red patches covered with white scales.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45/L40-/L40.9
has icd10 code: L40.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45/L40-/L40.9

other chondrocalcinosis, knee
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: a condition in which calcium pyrophosphate crystals build up in the knee
definition editor: Grace Whah
alternative term: CPPD
definition source: https://www.verywellhealth.com/what-is-chondrocalcinosis-2552216#:~:text=Chondrocalcinosis%2C%20also%20known%20as%20calcium,and%20other%20types%20of%20arthritis.
has icd10 code: M11.26
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M11-/M11.26

bilateral primary osteoarthritis of hip
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: degeneration of the tissues of the hip joint, including hyaline cartilage, fibrocartilage, bone, and synovium
definition editor: Grace Whah
alternative term: OA
definition source: https://journals.lww.com/jaaos/fulltext/2001/09000/primary_osteoarthritis_of_the_hip__etiology_and.5.aspx
has icd10 code: M16.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M15-M19/M16-/M16.0

Sciatica
type: Class
subclass of: disease (process) of the nervous system
definition: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/sciatica/symptoms-causes/syc-20377435#:~:text=Sciatica%20occurs%20when%20the%20sciatic,a%20disease%20such%20as%20diabetes.
has icd10 code: M54.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54.3

Nontraumatic compartment syndrome
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: a painful condition that occurs when pressure within the muscles builds to dangerous levels. This pressure can decrease blood flow, which prevents nourishment and oxygen from reaching nerve and muscle cells
definition editor: Grace Whah
definition source: https://orthoinfo.aaos.org/en/diseases--conditions/compartment-syndrome/#:~:text=Compartment%20syndrome%20is%20a%20painful,be%20either%20acute%20or%20chronic.
has icd10 code: M79
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M70-M79/M79-/M79.A

Tubulo-interstitial nephritis, not specified as acute or chronic
type: Class
subclass of: acute kidney failure or chronic kidney DP
definition: An acute or chronic inflammatory process affecting the kidney.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N12-/N12
has icd10 code: N12
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N12-/N12

Gestational diabetes mellitus
type: Class
subclass of: disease (process) related to pregnancy
definition: Gestational diabetes is diabetes that happens for the first time when a woman is pregnant. Gestational diabetes goes away when you have your baby, but it does increase your risk for having diabetes later.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.4
has icd10 code: O24.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.4

False labor before 37 completed weeks of gestation
type: Class
subclass of: disease (process) related to pregnancy
definition: irregular uterine contractions before the 37th week of pregnancy that mimick real labor
definition editor: Grace Whah
alternative term: Braxton hicks contractions
definition source: https://my.clevelandclinic.org/health/articles/9686-true-vs-false-labor
has icd10 code: O47.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O30-O48/O47-/O47.0

Anemia complicating pregnancy, childbirth and the puerperium
type: Class
subclass of: disease (process) related to pregnancy
definition: preexisting anemia in a pregnant woman that complicates pregnancy and childbirth
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O94-O9A/O99-/O99.0
has icd10 code: O99.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O94-O9A/O99-/O99.0

Palpitations
type: Class
subclass of: general symptoms
definition: A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart.
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/heart-palpitations/symptoms-causes/syc-20373196
has icd10 code: R00.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R00-/R00.2

Hemorrhage from respiratory passages
type: Class
subclass of: other diseases of the respiratory system
subclass of: symptoms, signs and abnormal clinical and laboratory findings
subclass of: Restriction
  on property: occurs in
  some values from: lung
definition: an acute bleeding from the lung, from the upper respiratory tract and the trachea, and the alveoli
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Pulmonary_hemorrhage#:~:text=Pulmonary%20hemorrhage%20(or%20pulmonary%20haemorrhage,the%20trachea%2C%20and%20the%20alveoli.&text=The%20onset%20of%20pulmonary%20hemorrhage,of%20oxygenation%20leading%20to%20cyanosis.
has icd10 code: R04
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04

Hypoesthesia of skin
type: Class
subclass of: skin DP
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: a decrease in your normal sensations in the skin such as touch or temperature
definition editor: Grace Whah
definition source: https://www.healthline.com/health/what-is-hypoesthesia#causes
has icd10 code: R20.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R20-R23/R20-/R20.1

ataxia, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: A disorder characterized by lack of coordination of muscle movements
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R25-R29/R27-/R27.0
has icd10 code: R27.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R25-R29/R27-/R27.0

visual hallucinations
type: Class
subclass of: general symptoms
definition: seeing things that aren't there
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/topics/neuroscience/visual-hallucination
has icd10 code: R44.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R44-/R44.1

Generalized edema
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: fluid accumulation that affects the whole body rather than particular organs or body areas.
definition editor: Grace Whah
definition source: https://www.news-medical.net/health/Generalized-Edema.aspx#:~:text=Generalized%20edema%20refers%20to%20fluid,particular%20organs%20or%20body%20areas.
has icd10 code: R60.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R60-/R60.1

unspecified fracture of upper end of humerus
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: fracture or break in the upper end of the humerus
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42/S42.2-/S42.20
has icd10 code: S42.20
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42/S42.2-/S42.20

fracture of greater trochanter of femur
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: fracture in the anatomical portions of the femur which serve as the attachment sites for several muscles.
definition editor: Grace Whah
definition source: https://radiopaedia.org/articles/isolated-greater-trochanteric-fracture-1
has icd10 code: S72.11
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.1-/S72.11

other complications of procedures, not elsewhere classified
type: Class
subclass of: complications of procedures
definition: complication occurs during procedure
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.8
has icd10 code: T81.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.8

Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
type: Class
subclass of: inflammation DP
definition: infection and/or inflammation resulting from the implanation of an internal device, implant, or graft
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.7
has icd10 code: T85.7
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.7

glucocorticoids and synthetic analogues
type: Class
subclass of: factors influencing health status and contact with health services
definition: application of an analog drug of cortisol that is used for its anti-inflammatory, immunosuppressive & antiproliferative effects
definition editor: Grace Whah
definition source: http://tmedweb.tulane.edu/pharmwiki/doku.php/all_steroid_drugs#:~:text=Synthetic%20glucocorticoids%20are%20analogs%20of,commonly%20used%20synthetic%20compounds%20include%3A&text=This%20protects%20the%20fetus%20from%20high%20levels%20of%20these%20glucocorticoids.
has icd10 code: Y42.0
source: https://icd.who.int/browse10/2016/en#/Y42.0

encounter for attention to tracheostomy
type: Class
subclass of: encounter for other specified aftercare
definition: an occurance that requires attention to a tracheostomy procedure
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.0
has icd10 code: Z43.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.0

encounter for attention to gastrostomy
type: Class
subclass of: encounter for other specified aftercare
definition: an occurance that requires attention to a gastrostomy procedure
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.1
has icd10 code: Z43.1
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.1

disease (process) of the liver
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K70 - K77
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77

Malignant neoplasm of liver and intrahepatic bile ducts
type: Class
subclass of: neoplasm DP
subclass of: disease (process) of the liver
definition editor: Grace Whah
has icd10 code: C22

disease (process) of gallbladder, biliary tract and pancreas
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K80-K87
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87

disease (process) of esophagus, stomach and duodenum
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K20 - K31
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31

other disease (process) of the intestines
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K55 - K64
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64

low income
type: Class
subclass of: factors influencing health status and contact with health services
definition: low amount of income (financial)
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.6
has icd10 code: Z59.6
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.6

problem related to housing and economic circumstances, unspecified
type: Class
subclass of: factors influencing health status and contact with health services
definition: financial problems related to housing or general economic standing
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.9
has icd10 code: Z59.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.9

problems related to care provider dependency
type: Class
subclass of: need for assistance with personal care
definition: problems related to dependency on health care providers
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74
has icd10 code: Z74
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74

other problems related to medical facilities and other health care
type: Class
subclass of: factors influencing health status and contact with health services
definition: other problems related to health care
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z75-/Z75.8
has icd10 code: Z75.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z75-/Z75.8

personal history of malignant neoplasm of digestive organs
type: Class
subclass of: personal status and history
definition: history of cancerous tumors of the digestive organs
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.0
has icd10 code: Z85.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.0

personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues
type: Class
subclass of: personal status and history
definition: history of cancerous tumors of the lymphoid, hematopoietic and related tissues
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.7
has icd10 code: Z85.7
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.7

patient's noncompliance with medical treatment and regimen
type: Class
subclass of: factors influencing health status and contact with health services
definition: patient refuses to follow medical treatment/regimen
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z91-/Z91.1
has icd10 code: Z91.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z91-/Z91.1

streptococcal sepsis
type: Class
subclass of: bacterial disease (process)
definition: an infection in the bloodstream that may travel to different body organs.
definition editor: Grace Whah
definition source: https://medlineplus.gov/ency/article/001366.htm#:~:text=Septicemia%20is%20an%20infection%20in,usually%20does%20not%20cause%20infection.
has icd10 code: A40
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A40-/A40

bacterial infection of unspecified site
type: Class
subclass of: bacterial disease (process)
definition: An acute infectious disorder of an unspecified site caused by gram positive or gram negative bacteria.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49
has icd10 code: A49
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49

bacterial infection, unspecified
type: Class
subclass of: bacterial disease (process)
definition: An unspecified acute infectious disorder caused by gram positive or gram negative bacteria.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49.9
has icd10 code: A49.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49.9

candidiasis
type: Class
subclass of: infectious and parasitic disease (process)
definition: A condition in which candida albicans, a type of yeast, grows out of control in moist skin areas of the body
definition editor: Grace Whah
alternative term: Thrush
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37
has icd10 code: B37
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37

invasive pulmonary aspergillosis
type: Class
subclass of: other diseases of the respiratory system
subclass of: infectious and parasitic disease (process)
subclass of: Restriction
  on property: occurs in
  some values from: lung
definition: Lung infections with the invasive forms of aspergillus
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B44-/B44.0
has icd10 code: B44.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B44-/B44.0

Streptococcus, Staphylococcus, and Enterococcus as the cause of diseases classified elsewhere
type: Class
subclass of: other bacterial agents as the cause of diseases classified elsewhere
definition: diseases with bacteria (Streptococcus, Staphylococcus, and Enterococcus ) as the cause
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95
has icd10 code: B95
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95

malignant neoplasm of brain
type: Class
subclass of: disease (process) of the nervous system
subclass of: neoplasm DP
definition: cancerous tumor of the brain
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C69-C72/C71-/C71
has icd10 code: C71
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C69-C72/C71-/C71

secondary malignant neoplasm of brain and cerebral meninges
type: Class
subclass of: neoplasm DP
definition: secondary cancerous tumor of the brain and cerebral meninges
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.3
has icd10 code: C79.3
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.3

acute lymphoblastic leukemia not having achieved remission
type: Class
subclass of: neoplasm DP
subclass of: disease processes of the blood stream
definition: An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow; no remission
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.00
has icd10 code: C91.00
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.00

neoplasm of unspecified behavior of brain
type: Class
subclass of: neoplasm DP
definition: a brain tumor that is currently benign but has characteristics that make it possible for the tumor to become malignant (cancerous)
definition editor: Grace Whah
definition source: https://providers.amerigroup.com/Documents/ALL_CARE_CF_V3I12Neoplasms.pdf
has icd10 code: D49.6
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/D49-D49/D49-/D49.6

disseminated intravascular coagulation [defibrination syndrome]
type: Class
subclass of: disease processes of the blood stream
definition: A disease where the blood clots throughout the body and increases the risk of bleeding
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D65-/D65
has icd10 code: D65
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D65-/D65

hyperuricemia without signs of inflammatory arthritis and tophaceous disease
type: Class
subclass of: disease processes of the blood stream
definition: an elevated uric acid level in the blood without symptoms of inflammatory arthritis and tophaceous disease
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Hyperuricemia#:~:text=Many%20factors%20contribute%20to%20hyperuricemia,consumption%20is%20the%20most%20important.
has icd10 code: E79.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E79-/E79.0

fluid overload
type: Class
subclass of: disease process
subclass of: metabolic disorders (NEW)
definition: Abnormal increase in the volume of circulating fluid (plasma) in the body.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.7
has icd10 code: E87.7
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.7

nicotine dependence
type: Class
subclass of: mood disorder due to known physiological condition
definition: dependence on nicotine
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F10-F19/F17-/F17
has icd10 code: F17
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F10-F19/F17-/F17

primary central sleep apnea
type: Class
subclass of: sleep apnea DP
definition: a potentially serious sleep disorder in which the brain makes no effort to breathe for short periods of time
definition source: https://www.mayoclinic.org/diseases-conditions/sleep-apnea/symptoms-causes/syc-20377631#:~:text=Sleep%20apnea%20is%20a%20potentially,occurs%20when%20throat%20muscles%20relax
has icd10 code: G47.31
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.31

sleep disorders
type: Class
subclass of: disease (process) of the nervous system
has icd10 code: G40 - G47
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47

high altitude periodic breathing
type: Class
subclass of: sleep disorders
definition: stopping breathing for a period of time (apnea) due to high altitude
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.32
has icd10 code: G47.32
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.32

other disorders of brain
type: Class
subclass of: disease (process) of the nervous system
definition: unspecified disorder of the brain
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G93-/G93
has icd10 code: G93
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G93-/G93

cardiomyopathy
type: Class
subclass of: disease (process) of the circulatory system
definition: A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I42-/I42
has icd10 code: I42
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I42-/I42

nontraumatic intracerebral hemorrhage
type: Class
subclass of: disease (process) of the nervous system
subclass of: cerebrovascular disease (process)
definition: Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma.
definition editor: Grace Whah
definition source: https://emedicine.medscape.com/article/1163977-overview#:~:text=Nontraumatic%20intracerebral%20hemorrhage%20most%20commonly,cold%20exposure)%2C%20rupture%20of%20an
has icd10 code: I61
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I61-/I61

other specified cerebrovascular diseases
type: Class
subclass of: cerebrovascular disease (process)
definition: diseases of the blood vessels in the brain
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Cerebrovascular_disease
has icd10 code: I67.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.8

cerebrovascular disease (process)
type: Class
subclass of: disease (process) of the circulatory system
subclass of: disease (process) of the nervous system
definition editor: Grace Whah
has icd10 code: I60 - I69
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69

acute cerebrovascular insufficiency
type: Class
subclass of: cerebrovascular disease (process)
definition: rare conditions that result in obstruction of one or more arteries that supply blood to the brain
definition editor: Grace Whah
definition source: https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/cerebrovascular/conditions/cerebrovascular_insufficiency.html#:~:text=Cerebrovascular%20insufficiency%20refers%20to%20a,or%20%22mini%20strokes%22).
has icd10 code: I67.81
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.81

cerebral ischemia
type: Class
subclass of: cerebrovascular disease (process)
definition: A disorder characterized by a decrease or absence of blood supply to the brain
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.82
has icd10 code: I67.82
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.82

embolism and thrombosis of superficial veins of lower extremities
type: Class
subclass of: disease processes of veins, lymphatic vessels and lymph nodes
definition: when a blood clot develops in a blood vessel of the lower extremities and becomes stuck, obstructing blood flow
definition editor: Grace Whah
definition source: https://www.healthline.com/health/thrombosis-vs-embolism#:~:text=Thrombosis%20occurs%20when%20a%20thrombus,obstructs%20the%20flow%20of%20blood.
has icd10 code: I82.81
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I80-I89/I82-/I82.81

acute bronchiolitis, unspecified
type: Class
subclass of: other acute lower respiratory infections
subclass of: Restriction
  on property: has quality
  some values from: acute
definition: an acute inflammatory injury of the bronchioles that is usually caused by a viral infection
definition editor: Grace Whah
definition source: https://emedicine.medscape.com/article/961963-overview#:~:text=Bronchiolitis%20is%20an%20acute%20inflammatory,seen%20in%20the%20image%20below.
has icd10 code: J21.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J21-/J21.9

intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
type: Class
subclass of: complications of procedures
definition: complications/disorders of the respiratory system that occur during or after a procedure/operation
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J95-J95/J95-/J95
has icd10 code: J95
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J95-J95/J95-/J95

diseases of bronchus, not elsewhere classified
type: Class
subclass of: other diseases of the respiratory system
definition: disease of the bronchus
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.0
has icd10 code: J98.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.0

respiratory disorders in other diseases classified elsewhere
type: Class
subclass of: other diseases of the respiratory system
definition: respiratory disorder as a result of another disorder found elsewhere in the body
definition editor: Grace Whah
definition source: https://icd.who.int/browse10/2016/en#/J99.8
has icd10 code: J99.8
source: https://icd.who.int/browse10/2016/en#/J99.8

liver disease, unspecified
type: Class
subclass of: disease (process) of the liver
definition: any disturbance of liver function that causes illness.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K76-/K76.9
has icd10 code: K76.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K76-/K76.9

dorsalgia
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: A disorder characterized by marked pain in the back region.
definition editor: Grace Whah
definition source: https://www.dorsalhealth.com/blog/what-is-dorsalgia-causes-treatment
has icd10 code: M54
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54

atrioventricular septal defect
type: Class
subclass of: disease (process) of the circulatory system
subclass of: congenital malformations of the circulatory system (NEW)
definition: a heart defect in which there are holes between the chambers of the right and left sides of the heart, and the valves that control the flow of blood between these chambers may not be formed correctly.
definition editor: Grace Whah
alternative term: AVSD
definition source: https://www.cdc.gov/ncbddd/heartdefects/avsd.html#:~:text=An%20atrioventricular%20septal%20defect%20(AVSD,may%20not%20be%20formed%20correctly.
has icd10 code: Q21.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q20-Q28/Q21-/Q21.2

congenital malformations, deformations and chromosomal abnormalities
type: Class
subclass of: disease process
definition editor: Grace Whah
has icd10 code: Q00 - Q99
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99

pain in throat and chest
type: Class
subclass of: general symptoms
definition: pain occuring in the throat and chest of the patient
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07
has icd10 code: R07
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07

aphagia
type: Class
subclass of: general symptoms
definition: inability or refusal to swallow.
definition editor: Grace Whah
definition source: https://en.wikipedia.org/wiki/Aphagia#Causes
has icd10 code: R13.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R13-/R13.0

symptoms and signs concerning food and fluid intake
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: symptoms that have to do with food/fluid intake
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63
has icd10 code: R63
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63

feeding difficulties
type: Class
subclass of: general symptoms
definition: difficulty feeding oneself
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.3
has icd10 code: R63.3
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.3

open wound of head
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: wound on head that is open
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S01-/S01
has icd10 code: S01
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S01-/S01

fracture of rib(s), sternum and thoracic spine
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: fracture or break on ribs, sternum and thoracic spine
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S20-S29/S22-/S22
has icd10 code: S22
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S20-S29/S22-/S22

fracture of shoulder and upper arm
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: fracture or break on shoulder or upper arm
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42-/S42
has icd10 code: S42
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42-/S42

infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: infection or inflammation due to the implementation of cardiac/vascular devices, implants, and grafts
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.7
has icd10 code: T82.7
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.7

other specified complications of cardiac and vascular prosthetic devices, implants and grafts
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: other complications due to implementation of cardiac/vascular devices, implaces, grafts
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.8
has icd10 code: T82.8
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.8

observation for suspected myocardial infarction
type: Class
subclass of: factors influencing health status and contact with health services
definition: observation by doctors of suspected myocardial infarction (heart attack)
definition editor: Grace Whah
definition source: https://www.icd10data.com/search
has icd10 code: Z03.4
source: https://www.icd10data.com/search

encounter for supervision of normal pregnancy
type: Class
subclass of: factors influencing health status and contact with health services
definition: normal doctors appointment to ensure healthy supervised pregnancy
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z30-Z39/Z34-/Z34
has icd10 code: Z34
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z30-Z39/Z34-/Z34

healthy person accompanying sick person
type: Class
subclass of: factors influencing health status and contact with health services
definition: healthy person (family, friend) staying with a sick patient
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z76-/Z76.3
has icd10 code: Z76.3
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z76-/Z76.3

other specified health status
type: Class
subclass of: factors influencing health status and contact with health services
definition: other specified health condition/status not coded for
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z78-/Z78.9
has icd10 code: Z78.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z78-/Z78.9

personal history of infectious and parasitic diseases
type: Class
subclass of: personal status and history
definition: history of infectious or parasitic diseases
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z86-/Z86.1
has icd10 code: Z86.1
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z86-/Z86.1

acquired absence of organs, not elsewhere classified
type: Class
subclass of: factors influencing health status and contact with health services
definition: removal of organ (surgery/injury)
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z90-/Z90
has icd10 code: Z90
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z90-/Z90

presence of other vascular implants and grafts
type: Class
subclass of: factors influencing health status and contact with health services
definition: patient has vascular implants/grafts
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.828
has icd10 code: Z95.828
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.828

breast implant status
type: Class
subclass of: factors influencing health status and contact with health services
definition: presence of breast implant
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z98-/Z98.82
has icd10 code: Z98.8
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z98-/Z98.82

other and unspecified malignant neoplasm of skin of lip
type: Class
subclass of: skin DP
subclass of: neoplasm DP
definition: cancerous tumor on skin of lip
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C43-C44/C44-/C44.0
has icd10 code: C44.0
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C43-C44/C44-/C44.0

polyneuropathy, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: A disorder affecting the cranial nerves or the peripheral nervous system.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G60-G65/G62-/G62.9
has icd10 code: G62.9
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G60-G65/G62-/G62.9

cognitive deficits following unspecified cerebrovascular disease
type: Class
subclass of: cerebrovascular disease (process)
definition: cognitive decline following cerebrovascular disease (disease of blood vessels in the brain)
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I69-/I69.91
has icd10 code: I69.91
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I69-/I69.91

postcardiotomy syndrome
type: Class
subclass of: disease (process) of the circulatory system
subclass of: complications of procedures
definition: A nonspecific hypersensitivity reaction caused by trauma causing pericardial effusion; high titers of anti-heart antibodies; low-grade fever; lethargy; loss of appetite; or abdominal pain.
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.0
has icd10 code: I97.0
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.0

postprocedural cardiac insufficiency following cardiac surgery
type: Class
subclass of: disease (process) of the circulatory system
subclass of: complications of procedures
definition: heart muscle's pump function is reduced following heart surgery
definition editor: Grace Whah
definition source: https://www.cardiosecur.com/magazine/specialist-articles-on-the-heart/cardiac-insufficiency-heart-failure#:~:text=Cardiac%20insufficiency%2C%20more%20commonly%20known,of%20blood%20throughout%20the%20body.
has icd10 code: I97.110
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.110

postprocedural heart failure following cardiac surgery
type: Class
subclass of: disease (process) of the circulatory system
subclass of: complications of procedures
definition: heart failure following heart surgery
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.130
has icd10 code: I97.130
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.130

other postprocedural cardiac functional disturbances following cardiac surgery
type: Class
subclass of: disease (process) of the circulatory system
definition: general cardiac funciton abnormalities following heart surgery
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.190
has icd10 code: I97.190
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.190

chronic respiratory failure, unspecified whether with hypoxia or hypercapnia
type: Class
subclass of: acute and chronic respiratory failure
definition: a condition that results in the inability to effectively exchange carbon dioxide and oxygen, and induces chronically low oxygen levels or chronically high carbon dioxide levels, unspecified which
definition editor: Grace Whah
definition source: https://www.sciencedirect.com/topics/medicine-and-dentistry/chronic-respiratory-failure#:~:text=Chronic%20respiratory%20failure%20is%20a,chronically%20high%20carbon%20dioxide%20levels.
has icd10 code: J96.10
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J96-/J96.10

acanthosis nigricans
type: Class
subclass of: skin DP
definition: a skin condition that causes a dark discoloration in body folds and creases. It typically affects the armpits, groin and neck.
definition editor: Grace Whah
definition source: https://www.mayoclinic.org/diseases-conditions/acanthosis-nigricans/symptoms-causes/syc-20368983#:~:text=Acanthosis%20nigricans%20is%20a%20skin,affected%20skin%20can%20become%20thickened.
has icd10 code: L83
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L83-/L83

pressure ulcer of unspecified part of back
type: Class
subclass of: pressure ulcer
definition: injuries to skin on back and underlying tissue resulting from prolonged pressure on the skin.
definition editor: Grace Whah
alternative term: bedsores
definition source: https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893
has icd10 code: L89.10
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.10

arthropathies in other specified diseases classified elsewhere, multiple sites
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: disease of the joints found in other diseases, multiple locations
definition editor: Grace Whah
definition source: https://www.disnola.com/what-is-arthropathy/#:~:text=Arthropathy%20means%20any%20disease%20of,as%20rheumatoid%20arthritis%20and%20osteoarthritis.
has icd10 code: M14.89
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M14-/M14.89

supervision of pregnancy with grand multiparity
type: Class
subclass of: disease (process) related to pregnancy
definition: supervision of a pregnancy in a woman who has delivered 5 or more infants who has achieved a gestational age of 24+ weeks
definition editor: Grace Whah
definition source: https://patient.info/doctor/gravidity-and-parity-definitions-and-their-implications-in-risk-assessment#:~:text=A%20grand%20multipara%20is%20a,pregnant%20five%20times%20or%20more.
has icd10 code: O09.4
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O09-O09/O09-/O09.4

mechanical complication of other specified internal and external prosthetic devices, implants and grafts
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: complication in mechanical design.function of internal and external prosthetic devices, implants and grafts
definition editor: Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.6
has icd10 code: T85.6
code billability: Non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.6

malignant neoplasm of eye
type: Class
subclass of: neoplasm DP
subclass of: other disorders of eye and adnexa (NEW)
definition: cancerous tumor of the eye
definition editor: Grace Whah
definition source: http://www.icd9data.com/2015/Volume1/140-239/190-199/190/190.htm
has icd9 code: 190
code billability: Non-billable
source: http://www.icd9data.com/2015/Volume1/140-239/190-199/190/190.htm

malignant neoplasm of other and unspecified parts of nervous system
type: Class
subclass of: neoplasm DP
definition: cancerous tumors within parts of the nervous system
definition editor: Grace Whah
definition source: http://www.icd9data.com/2015/Volume1/140-239/190-199/192/192.htm
has icd9 code: 192
code billability: Non-billable
source: http://www.icd9data.com/2015/Volume1/140-239/190-199/192/192.htm

external ear biopsy (Biopsy of external ear)
type: Class
subclass of: external ear DP
definition: a sample of tissue taken from the external ear in order to examine it more closely.
definition editor: Grace Whah
definition source: https://www.webmd.com/cancer/what-is-a-biopsy#1
has icd9 code: 1812
source: https://www.hipaaspace.com/medical_billing/coding/icd-9/procedure/1812

nutritional and metabolic cardiomyopathy
type: Class
subclass of: disease (process) of the circulatory system
definition: a chronic metabolic disease characterized by structural and functional alterations and interstitial fibrosis without coronary artery disease or hypertension
definition editor: Grace Whah
definition source: https://academic.oup.com/cardiovascres/article/113/4/389/3061106#:~:text=Metabolic%20cardiomyopathy%20is%20a%20chronic,coronary%20artery%20disease%20or%20hypertension.
has icd9 code: 4257
source: https://dexur.com/icd9/4257/

stomatitis and mucositis (ulcerative)
type: Class
subclass of: disease (process) of esophagus, stomach and duodenum
definition: Mucositis is painful inflammation or ulceration of the mucous membranes anywhere along the gastrointestinal tract. Stomatitis (oral mucositis) refers to inflammation and ulceration that occur in the mouth.
definition editor: Grace Whah
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743583/#:~:text=Mucositis%20is%20painful%20inflammation%20or,lips%2C%20and%20roof%20or%20floor.
has icd9 code: 5280
source: https://dexur.com/icd9/5280/

chronic obstructive pulmonary disease (NEW)
type: Class
subclass of: chronic lower respiratory diseases
definition editor: Grace Whah

respiratory failure (NEW)
type: Class
subclass of: disease (process) in the respiratory system
definition editor: Grace Whah

respiratory infections (NEW)
type: Class
subclass of: disease (process) in the respiratory system
definition editor: Grace Whah

influeza and pneumonia (NEW)
type: Class
subclass of: disease (process) in the respiratory system
definition editor: Grace Whah
has icd10 code: J09-J18
has ICD10 name: Influenza and pneumonia
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18

diseases of oral cavity and salivary glands (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K00-K14
has ICD10 name: diseases of oral cavity and salivary glands
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K00-K14

diseases of appendix (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K35-K38
has ICD10 name: diseases of appendix
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K35-K38

hernia (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K40-K46
has ICD10 name: hernia
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46

noninfective enteritis and colitis (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K50-K52
has ICD10 name: noninfective enteritis and colitis
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52

diseases of peritoneum and retroperitoneum (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K65-K68
has ICD10 name: diseases of peritoneum and retroperitoneum
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K65-K68

other diseases of the digestive system (NEW)
type: Class
subclass of: disease (process) of the digestive system
definition editor: Grace Whah
has icd10 code: K90-K95
has ICD10 name: other diseases of the digestive system
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95

disorders of eyelid, lacrimal system and orbit (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H00-H05
has ICD10 name: disorders of eyelid, lacrimal system and orbit
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H00-H05

disorders of conjunctiva (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H10-H11
has ICD10 name: disorders of conjunctiva
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H10-H11

disorders of sclera, cornea, iris and ciliary body (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H15-H22
has ICD10 name: disorders of sclera, cornea, iris and ciliary body
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H15-H22

disorders of lens (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H25-H28
has ICD10 name: disorders of lens
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28

disorders of choroid and retina (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H30-H36
has ICD10 name: disorders of choroid and retina
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H30-H36

glaucoma (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H40-H42
has ICD10 name: glaucoma
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H40-H42

disorders of vitreous body and globe (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H43-H44
has ICD10 name: disorders of vitreous body and globe
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H43-H44

disorders of optic nerve and visual pathways (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H46-H47
has ICD10 name: disorders of optic nerve and visual pathways
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H46-H47

disorders of ocular muscles, binocular movement, accommodation and refraction (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H49-H52
has ICD10 name: Disorders of ocular muscles, binocular movement, accommodation and refraction
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H49-H52

visual disturbances and blindness (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H53-H54
has ICD10 name: visual disturbances and blindness
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54

other disorders of eye and adnexa (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H55-H57
has ICD10 name: other disorders of eye and adnexa
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H55-H57

intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified (NEW)
type: Class
subclass of: disease (process) of the eye and adnexa
definition editor: Grace Whah
has icd10 code: H59-H59
has ICD10 name: intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H59-H59

acute rheumatic fever (NEW)
type: Class
subclass of: disease (process) of the circulatory system
definition editor: Grace Whah
has icd10 code: I00-I02
has ICD10 name: acute rheumatic fever
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I00-I02

chronic rheumatic heart diseases (NEW)
type: Class
subclass of: disease (process) of the circulatory system
definition editor: Grace Whah
has icd10 code: I05-I09
has ICD10 name: chronic rheumatic heart diseases
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I05-I09

hypertensive diseases (NEW)
type: Class
subclass of: disease (process) of the circulatory system
definition editor: Grace Whah
has icd10 code: I10-I16
has ICD10 name: hypertensive diseases
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16

congenital malformations of the nervous system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q00-Q07
has ICD10 name: congential malformations of the nervous system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q00-Q07

congenital malformations of eye, ear, face and neck (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q10-Q18
has ICD10 name: congenital malformations of eye, ear, face and neck
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q10-Q18

congenital malformations of the circulatory system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q20-Q28
has ICD10 name: congenital malformations of the circulatory system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q20-Q28

congenital malformations of the respiratory system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q30-Q34
has ICD10 name: congenital malformations of the respiratory system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q30-Q34

cleft lip and cleft palate (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q35-Q37
has ICD10 name: cleft lip and cleft palate
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q35-Q37

other congenital malformations of the digestive system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q38-Q45
has ICD10 name: other congenital malformations of the digestive system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45

congenital malformations of genital organs (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q50-Q56
has ICD10 name: congenital malformations of genital organs
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q50-Q56

congenital malformations of the urinary system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q60-Q64
has ICD10 name: congenital malformations of the urinary system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q60-Q64

congenital malformations and deformations of the musculoskeletal system (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q65-Q79
has ICD10 name: congenital malformations and deformations of the musculoskeletal system
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q65-Q79

other congenital malformations (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q80-Q89
has ICD10 name: other congenital malformations
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q80-Q89

chromosomal abnormalities, not elsewhere classified (NEW)
type: Class
subclass of: congenital malformations, deformations and chromosomal abnormalities
definition editor: Grace Whah
has icd10 code: Q90-Q99
has ICD10 name: chromosomal abnormalities, not elsewhere classified
source: https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q90-Q99

infections of the skin and subcutaneous tissue (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L00-L08
has ICD10 name: infections of the skin and subcutaneous tissue
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L00-L08v

bullous disorders (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L10-L14
has ICD10 name: bullous disorders
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L10-L14

dermatitis and eczema (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L20-L30
has ICD10 name: dermatitis and eczema
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L20-L30

papulosquamous disorders (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L40-L45
has ICD10 name: papulosquamous disorders
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45

urticaria and erythema (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L49-L54
has ICD10 name: urticaria and erythema
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L49-L54

radiation-related disorders of the skin and subcutaneous tissue (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L55-L59
has ICD10 name: radiation-related disorders of the skin and subcutaneous tissue
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L55-L59

disorders of skin appendages (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L60-L75
has ICD10 name: disorders of skin appendages
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L60-L75

intraoperative and postprocedural complications of skin and subcutaneous tissue (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L76-L76
has ICD10 name: intraoperative and postprocedural complications of skin and subcutaneous tissue
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L76-L76

other disorders of the skin and subcutaneous tissue (NEW)
type: Class
subclass of: disorders of the skin and subcutaneous tissue
definition editor: Grace Whah
has icd10 code: L80-L99
has ICD10 name: other disorders of the skin and subcutaneous tissue
source: https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99

endocrine, nutritional and metabolic diseases (NEW)
type: Class
subclass of: disease process
definition editor: Grace Whah
has icd10 code: E00-E89
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89

disorders of thyroid gland (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E00-E07
has ICD10 name: disorders of thyroid gland
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07

diabetes mellitus (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E08-E13
has ICD10 name: diabetes mellitus
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13

other disorders of glucose regulation and pancreatic internal secretion (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E15-E16
has ICD10 name: other disorders of glucose regulation and pancreatic internal secretion
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E15-E16

disorders of other endocrine glands (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E20-E35
has ICD10 name: disorders of other endocrine glands
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E20-E35

intraoperative complications of endocrine system (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E36-E36
has ICD10 name: Intraoperative complications of endocrine system
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E36-E36

malnutrition (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E40-E46
has ICD10 name: Malnutrition
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46

other nutritional deficiencies (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E50-E64
has ICD10 name: Other nutritional deficiencies
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64

overweight, obesity and other hyperalimentation (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E65-E68
has ICD10 name: Overweight, obesity and other hyperalimentation
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68

metabolic disorders (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E70-E88
has ICD10 name: Metabolic disorders
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88

postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (NEW)
type: Class
subclass of: endocrine, nutritional and metabolic diseases (NEW)
definition editor: Grace Whah
has icd10 code: E89-E89
has ICD10 name: Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified
source: https://www.icd10data.com/ICD10CM/Codes/E00-E89

other infective otitis externa DP
type: Class
equivalent class: Restriction
  on property: has DP material quality
  some values from: infectious
equivalent class: Restriction
  on property: has DP material quality
  some values from: other
subclass of: other specified infectious diseases of external ear DP
subclass of: Restriction
  on property: has DP material quality
  some values from: other
has gbt_14396 code: H60.300
has icd10 code: H60.3
label: 感染性外耳炎，其他的 @zh

cholesteatoma of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: cholesteatoma entity
subclass of: cholesteatoma DP
has gbt_14396 code: H60.400
has icd10 code: H60.4
has ICD10 name: cholesteatoma of external ear
label: 外耳胆脂瘤 @zh

noninfective DP of pinna
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP material quality
    some values from: noninfectious
subclass of: external ear DP
has gbt_14396 code: H61.100
has icd10 code: H61.1
has ICD10 name: noninfective disorders of pinna
label: 耳郭非感染性疾患病程 @zh

other specified disorders of external ear DP
type: Class
subclass of: Obsolete class
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
has gbt_14396 code: H61.800 @zh
has icd10 code: H61.8 @zh
label: 外耳其他特指的疾患 @zh

disorders of external ear in diseases classified elsewhere DP
type: Class
subclass of: Obsolete class
subclass of: Restriction
  on property: has DP material quality
  some values from: diseases claasified elsewhere
has icd10 code: H62
label: 分类于他处的的外耳疾患 @zh

otitis externa in bacterial diseases classified elsewhere DP
type: Class
subclass of: disorders of external ear in diseases classified elsewhere DP
subclass of: Restriction
  on property: has DP material quality
  some values from: diseases claasified elsewhere
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious via bacterium
has_alternative_id in icd10: A46†
has icd10 code: H62.0
has_related_synonym: Otitis externa in erysipelas

otitis externa in viral diseases classified elsewhere DP
type: Class
subclass of: disorders of external ear in diseases classified elsewhere DP
subclass of: Restriction
  on property: has DP material quality
  some values from: viral
has_alternative_id in icd10: B00.1†
has_alternative_id in icd10: B02.8†
has_alternative_id in icd10: Otitis externa in herpesviral [herpes simplex] infection
has icd10 code: H62.1
has_related_synonym: Otitis externa in zoster

otitis externa in mycoses DP
type: Class
subclass of: otomycosis DP
has_alternative_id in icd10: B36.9†
has_alternative_id in icd10: B37.2†
has_alternative_id in icd10: B44.8†
has icd10 code: H62.2
has ICD10 name: otitis externa in mycoses
has_related_synonym: Otitis externa in aspergillosis
has_related_synonym: Otitis externa in candidiasis
has_related_synonym: Otomycosis NOS
label: 真菌性外耳炎 @zh

otitis externa in other infectious and parasitic diseases classified elsewhere DP
type: Class
subclass of: disorders of external ear in diseases classified elsewhere DP
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious
subclass of: Restriction
  on property: has DP material quality
  some values from: diseases claasified elsewhere
subclass of: Restriction
  on property: has DP material quality
  some values from: parasitic
has icd10 code: H62.3

otitis externa in other diseases classified elsewhere DP
type: Class
subclass of: disorders of external ear in diseases classified elsewhere DP
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: diseases claasified elsewhere
has icd10 code: H62.4
has_alternative_id: L01.-†
has_related_synonym: Otitis externa in impetigo

other disorders of external ear in diseases classified elsewhere DP
type: Class
subclass of: disorders of external ear in diseases classified elsewhere DP
subclass of: Restriction
  on property: has DP material quality
  some values from: other
has icd10 code: H62.8

erysipelas of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: erysipelas
subclass of: infectious DP of external ear
subclass of: Restriction
  on property: has DP output
  some values from: erysipelas
has icd11 code: 1B70.01
has ICD10 name: erysipelas of external ear
label: 外耳丹毒 @zh

aspergillus otomycosis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: mycotic
  intersection of: Restriction
    on property: caused by
    some values from: Aspergillus
subclass of: otomycosis DP
has icd11 code: 1F20.10
has ICD10 name: aspergillus otomycosis
label: 曲霉菌真菌病 @zh

candida otomycosis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: mycotic
  intersection of: Restriction
    on property: caused by
    some values from: Candida
subclass of: otomycosis DP
has icd11 code: 1F23.16
has ICD10 name: candida otomycosis
label: 念珠菌属真菌病 @zh

cellulitis of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: cellulitis anatomical entity
subclass of: cellulitis DP
has gbt_14396 code: H60.100
has icd11 code: AA01
has icd10 code: H60.1
has ICD10 name: cellulitis of external ear
label: 外耳蜂窝织炎病程 @zh

malignant otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: neoplastic, malignant
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has gbt_14396 code: H60.200
has icd11 code: AA02
has icd10 code: H60.2
has ICD10 name: malignant otitis externa
label: 恶性外耳炎 @zh

otomycosis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: ear
  intersection of: Restriction
    on property: caused by
    some values from: fungus
subclass of: mycosis DP
has icd11 code: AA03
has ICD10 name: otomycosis
label: 耳真菌病 @zh

perichondritis of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: perichondritis anatomical entity
subclass of: perichondritis DP
subclass of: chondritis or perichondritis of external ear
has gbt_14396 code: H61.000
has icd11 code: AA04
has icd10 code: H61.0
has ICD10 name: perichondritis of external ear
label: 外耳软骨膜炎 @zh

other specified infectious diseases of external ear DP
type: Class
subclass of: other specified disorders of external ear DP
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
has icd11 code: AA0Y
label: 其他特指的外耳感染 @zh

Infectious DP of external ear, unspecified
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: infectious
  intersection of: Restriction
    on property: has DP material quality
    some values from: unspecified
subclass of: infectious DP of external ear
has icd11 code: AA0Z
has ICD10 name: Infectious diseases of external ear, unspecified
label: 耳廓感染，未特指的 @zh

seborrhoeic otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: seborrhoeic
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has icd11 code: AA10
has ICD10 name: seborrhoeic otitis externa DP
label: 外耳脂溢性皮炎 @zh

acute noninfectious otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: noninfectious
  intersection of: Restriction
    on property: has DP material quality
    some values from: acute
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has gbt_14396 code: H60.500
has icd11 code: AA11
has icd10 code: H60.5
has ICD10 name: acute noninfectious otitis externa
has_exact_synonym: acute otitis externa, noninfective DP
label: 急性非感染性耳炎 @zh

chondrodermatitis nodularis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: cartilage tissue
  intersection of: Restriction
    on property: has DP material quality
    some values from: nodularis
  intersection of: Restriction
    on property: has DP output
    some values from: dermatitis anatomical entity
subclass of: noninfectious inflammation of external ear DP
subclass of: Restriction
  on property: has DP output
  some values from: dermatitis anatomical entity
has icd11 code: AA12
has ICD10 name: chondrodermatitis nodularis
label: 结节性软骨皮炎病程 @zh

chronic otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: chronic
  intersection of: Restriction
    on property: has process profile
    some values from: chronic disease profile
subclass of: otitis externa DP
has gbt_14396 code: H60.801
has icd11 code: AA13
has ICD10 name: chronic otitis externa
label: 慢性外耳炎 @zh

other specified noninfectious inflammation of external ear DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: noninfectious inflammation DP
subclass of: Obsolete class
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
subclass of: Restriction
  on property: has DP output
  some values from: otitis DP
subclass of: Restriction
  on property: has DP output
  some values from: noninfectious inflammation DP
has icd11 code: AA1Y
label: 其他特指的非感染性外耳炎症 @zh

Noninfectious inflammation of external ear, unspecified DP
type: Class
subclass of: noninfectious inflammation DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: unspecified
subclass of: Restriction
  on property: has DP material quality
  some values from: noninfectious
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
has icd11 code: AA1Z
has ICD10 name: Noninfectious inflammation of external ear, unspecified
label: 外耳非感染性炎症，未特指的 @zh

otitis externa, unspecified DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: unspecified
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has icd11 code: AA3Z
has ICD10 name: otitis externa, unspecified
label: 外耳炎，未特指的 @zh

acquired deformity of external auditory canal DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP material quality
    some values from: acquired
  intersection of: Restriction
    on property: has DP output
    some values from: deformity entity
subclass of: deformity DP
has icd11 code: AA40
has ICD10 name: acquired deformity of external auditory canal
label: 获得性外耳道畸形 @zh

exostosis of external canal DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: exostosis
subclass of: exostosis DP
has gbt_14396 code: H61.802
has icd11 code: AA40.0
has icd10 code: H61.8
has ICD10 name: exostosis of external canal
label: 外耳道外生骨疣 @zh

acquired stenosis of external auditory canal DP
type: Class
subclass of: stenosis DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP material quality
  some values from: acquired
subclass of: Restriction
  on property: has DP output
  some values from: stenosis
has gbt_14396 code: H61.300
has icd11 code: AA40.1
has icd10 code: H61.3
has ICD10 name: acquired stenosis of external auditory canal
label: 后天性外耳道狭窄 @zh

cholesteatoma of external auditory canal DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: cholesteatoma entity
subclass of: cholesteatoma of external ear DP
has icd11 code: AA40.2
has icd10 code: H60.4
has ICD10 name: cholesteatoma of external auditory canal
label: 外耳道胆脂瘤 @zh

other specified acquired deformity of external auditory canal DP
type: Class
subclass of: Obsolete class
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP material quality
  some values from: acquired
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
subclass of: Restriction
  on property: has DP output
  some values from: deformity entity
has icd11 code: AA40.Y
label: 其他特指的获得性外耳道畸形 @zh

acquired deformity of pinna DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP material quality
    some values from: acquired
  intersection of: Restriction
    on property: has DP output
    some values from: deformity entity
subclass of: deformity DP
has icd11 code: AA41
has ICD10 name: acquired deformity of pinna
has_exact_synonym: 后天性耳廓畸形 @zh
label: 获得性耳廓畸形 @zh

cauliflower ear DP
type: Class
equivalent class: Restriction
  on property: has DP output
  some values from: cauliflower ear
subclass of: deformity DP
subclass of: Restriction
  on property: has DP output
  some values from: cauliflower ear
alternative term: Cauliflower ear
has icd11 code: AA41.0
label: 菜花耳 @zh

other specified acquired deformity of pinna DP
type: Class
subclass of: Obsolete class
subclass of: Restriction
  on property: occurs in
  some values from: pinna
subclass of: Restriction
  on property: has DP material quality
  some values from: acquired
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
subclass of: Restriction
  on property: has DP output
  some values from: deformity entity
has icd11 code: AA41.Y
label: 其他特指的获得性耳廓畸形 @zh

impacted cerumen DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: cerumen
  intersection of: Restriction
    on property: has DP material quality
    some values from: impacted
subclass of: noninflammatory DP of the external ear
has gbt_14396 code: H61.200
has icd11 code: AA42
has icd10 code: H61.2
has ICD10 name: impacted cerumen
label: 耵聍栓塞 @zh

other specified noninflammatory disorders of the external ear DP
type: Class
subclass of: Obsolete class
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
has icd11 code: AA4Y
label: 其他特指的外耳非感染性疾患 @zh

noninflammatory DP of the external ear, unspecified
type: Class
subclass of: noninflammatory DP of the external ear
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: unspecified
subclass of: Restriction
  on property: has DP material quality
  some values from: noninflammatory
has icd11 code: AA4Z
has ICD10 name: noninflammatory disorders of the external ear, unspecified
label: 外耳非感染性疾患，未特指的 @zh

external ear, unspecified DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: unspecified
subclass of: external ear DP
has gbt_14396 code: H61.900
has icd11 code: AA6Z
has icd10 code: H61.9
has ICD10 name: diseases of external ear, unspecified
label: 耳廓疾病病程，未特指的 @zh

ear-lobe keloid DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: lobule of pinna
  intersection of: Restriction
    on property: has DP output
    some values from: keloid entity
subclass of: keloid DP
has icd11 code: EE60.00
has ICD10 name: ear-lobe keloid
label: 耳垂瘢痕瘤病程 @zh

contact dermatitis of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: in contact with
  intersection of: Restriction
    on property: has DP output
    some values from: dermatitis anatomical entity
subclass of: otitis externa DP
has icd11 code: EG40
has ICD10 name: contact dermatitis of external ear
label: 外耳接触性皮炎 @zh

granuloma of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: granuloma
subclass of: granuloma DP
has gbt_14396 code: H60.401
has ICD10 name: granuloma of external ear
label: 外耳肉芽肿 @zh

obstructive keratosis of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: obstructive
  intersection of: Restriction
    on property: has DP output
    some values from: keratosis entity
subclass of: keratosis DP
has gbt_14396 code: H60.402
has ICD10 name: obstructive keratosis of external ear
label: 外耳阻塞性角化病程 @zh

external ear canal cyst DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: cyst
subclass of: cyst DP
has gbt_14396 code: H61.806
has ICD10 name: external ear canal cyst
label: 外耳道囊肿 @zh

hemorrhagic otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: hemorrhagic
subclass of: otitis externa DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: hemorrhagic
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
has gbt_14396 code: H60.301
has ICD10 name: hemorrhagic otitis externa
label: 出血性外耳炎 @zh

diffuse otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: diffuse
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has gbt_14396 code: H60.302
has ICD10 name: diffuse otitis externa
label: 弥漫性外耳炎 @zh

swimmer's ear DP
type: Class
subclass of: infectious DP of external ear
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: infectious
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
subclass of: Restriction
  on property: caused by
  some values from: water
subclass of: Restriction
  on property: topDataProperty
  some values from: Literal
has gbt_14396 code: H60.303
has ICD10 name: swimmer's ear
has_exact_synonym: beach ear DP
label: 游泳者耳病 @zh

granuloma of external ear canal DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: granuloma
subclass of: granuloma DP
has gbt_14396 code: H60.403
has ICD10 name: granuloma of external ear canal
label: 外耳道肉芽肿 @zh

acute eczematoid otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: eczema entity
subclass of: otitis externa DP
has gbt_14396 code: H60.501
has icd10 code: H60.54
has ICD10 name: acute eczematoid otitis externa
label: 外耳湿疹 @zh

acute actinic otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: acute
  intersection of: Restriction
    on property: caused by
    some values from: sunlight
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has gbt_14396 code: H60.502
has icd10 code: H60.51
has ICD10 name: acute actinic otitis externa
label: 急性光化性外耳炎 @zh

acute chemical otitis externa DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: acute
  intersection of: Restriction
    on property: caused by
    some values from: chemical entity
  intersection of: Restriction
    on property: has DP output
    some values from: otitis anatomical entity
subclass of: otitis externa DP
has gbt_14396 code: H60.503
has icd10 code: H60.52
has ICD10 name: acute chemical otitis externa
label: 急性化学性外耳炎 @zh

chondrodermatitis nodularis chronica helicis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: cartilage tissue
  intersection of: Restriction
    on property: occurs in
    some values from: helix of outer ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: nodularis
  intersection of: Restriction
    on property: has process profile
    some values from: chronic disease profile
subclass of: dermatitis DP
has gbt_14396 code: H61.001
has ICD10 name: chondrodermatitis nodularis chronica helicis
label: 慢性结节性耳轮软骨皮炎 @zh

pinna scar DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP output
    some values from: scar entity
subclass of: scar DP
has gbt_14396 code: H61.002
has ICD10 name: pinna scar
label: 耳郭瘢痕病程 @zh

acquired deformity of external ear DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP material quality
    some values from: acquired
  intersection of: Restriction
    on property: has DP output
    some values from: deformity entity
subclass of: deformity DP
has gbt_14396 code: H61.101
has ICD10 name: acquired deformity of external ear
label: 后天性外耳畸形 @zh

pinna pseudocyst DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP output
    some values from: pseudocyst
subclass of: pseudocyst DP
has gbt_14396 code: H61.103
has ICD10 name: pinna pseudocyst
label: 耳郭假性囊肿 @zh

hematoma ossification behind ear DP
type: Class
subclass of: ossification DP
subclass of: Restriction
  on property: occurs in
  some values from: behind ear
subclass of: Restriction
  on property: has DP material quality
  some values from: hematoma
subclass of: Restriction
  on property: has DP output
  some values from: ossification entity
has gbt_14396 code: H61.104
has ICD10 name: hematoma ossification behind ear
label: 耳后血肿骨化 @zh

pinna tumor DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: pinna
  intersection of: Restriction
    on property: has DP output
    some values from: tumor
subclass of: tumor DP
has gbt_14396 code: H61.105
has ICD10 name: pinna tumor
label: 耳郭肿物 @zh

temporomandibular joint external ear canal hernia DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: occurs in
    some values from: temporomandibular joint
  intersection of: Restriction
    on property: has DP output
    some values from: hernia
subclass of: hernia DP
has gbt_14396 code: H61.801
has ICD10 name: temporomandibular joint external ear canal hernia
label: 颞下颌关节外耳道疝 @zh

external ear fistula DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external ear
  intersection of: Restriction
    on property: has DP output
    some values from: fistula
subclass of: fistula DP
has gbt_14396 code: H61.803
has ICD10 name: external ear fistula
label: 外耳瘘 @zh

external ear canal keratosis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: keratosis entity
subclass of: keratosis DP
has gbt_14396 code: H61.804
has ICD10 name: external ear canal keratosis
label: 外耳道角化症病程 @zh

external ear canal necrosis DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: necrosis entity
subclass of: necrosis DP
has gbt_14396 code: H61.805
has ICD10 name: external ear canal necrosis
label: 外耳道坏死 @zh

external ear canal tumor DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP output
    some values from: tumor
subclass of: tumor DP
has gbt_14396 code: H61.901
has ICD10 name: external ear canal tumor
label: 外耳道肿物 @zh

acquired external ear canal atresia DP
type: Class
equivalent class: Class
  intersection of: Restriction
    on property: occurs in
    some values from: external acoustic meatus
  intersection of: Restriction
    on property: has DP material quality
    some values from: acquired
  intersection of: Restriction
    on property: has DP output
    some values from: atresia entity
subclass of: atresia DP
has gbt_14396 code: H61.902
has ICD10 name: acquired external ear canal atresia
label: 后天性外耳道闭锁 @zh

disease
type: Class
subclass of: disposition
definition: A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
imported from: OBO Relations Ontology

bodily process
type: Class
subclass of: process
definition editor: Albert Goldfain
curator note: creation date: 2009-06-23T11:53:49Z
imported from: ogms.owl

pathological bodily process
type: Class
subclass of: bodily process
definition: A bodily process that is clinically abnormal.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:54:29Z
imported from: ogms.owl

pathological transformation
type: Class
subclass of: pathological bodily process
definition: A pathological bodily process in which a canonical anatomical structure becomes a pathological anatomical structure.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf
curator note: creation date: 2009-07-13T02:17:07Z
imported from: ogms.owl

pathological derivation
type: Class
subclass of: pathological bodily process
definition: A pathological bodily process in which matter is reorganized in such a way as to give rise to new pathological formations which take the place of entities existing earlier.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf
curator note: creation date: 2009-07-13T02:17:24Z
imported from: ogms.owl

pathological invasion
type: Class
subclass of: pathological bodily process
definition: TODO: Define.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf
curator note: creation date: 2009-07-13T02:17:47Z
imported from: ogms.owl

quality
type: Class
subclass of: specifically dependent continuant
imported from: OBO Relations Ontology
OBO foundry unique label: quality (PATO)

morphology
type: Class
subclass of: physical object quality
definition: A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000051
in_subset: attribute slim
label: 形态学的 @zh

structure
type: Class
subclass of: morphology
definition: A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
imported from: pato.owl
has_alternative_id: PATO:0001452
has_broad_synonym: conformation
has_exact_synonym: relational structural quality
has_obo_namespace: quality
id: PATO:0000141
in_subset: attribute slim
label: 结构性 @zh

acute
type: Class
subclass of: duration
definition: A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course.
imported from: pato.owl
is opposite of: chronic
has_obo_namespace: quality
id: PATO:0000389
in_subset: hpo slim
in_subset: mpath slim
in_subset: value slim
label: 急性 @zh

process quality
type: Class
subclass of: quality
definition: A quality which inheres in an process.
imported from: pato.owl
has_alternative_id: PATO:0001239
has_alternative_id: PATO:0001240
has_exact_synonym: quality of a process
has_exact_synonym: quality of occurrent
has_exact_synonym: quality of process
has_exact_synonym: relational quality of occurrent
has_obo_namespace: quality
id: PATO:0001236
comment: See comments of relational quality of a physical entity.

physical object quality
type: Class
subclass of: quality
definition: A quality which inheres in a continuant.
imported from: pato.owl
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
database_cross_reference: snap:Quality
has_exact_synonym: monadic quality of a continuant
has_exact_synonym: multiply inhering quality of a physical entity
has_exact_synonym: quality of a continuant
has_exact_synonym: quality of a single physical entity
has_exact_synonym: quality of an object
has_exact_synonym: quality of continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_obo_namespace: quality
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.

duration
type: Class
subclass of: physical quality of a process
definition: A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
imported from: pato.owl
has_alternative_id: PATO:0000081
has_exact_synonym: period
has_obo_namespace: quality
has_related_synonym: time
id: PATO:0001309
in_subset: attribute slim
in_subset: hpo slim

constricted
type: Class
subclass of: structure
definition: A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically.
imported from: pato.owl
has_alternative_id: PATO:0001837
has_exact_synonym: stenosis
has_exact_synonym: stenotic
has_exact_synonym: stricture
has_obo_namespace: quality
id: PATO:0001847
in_subset: value slim
label: 狭窄的 @zh

chronic
type: Class
subclass of: duration
definition: A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration.
imported from: pato.owl
is opposite of: acute
has_obo_namespace: quality
id: PATO:0001863
in_subset: hpo slim
in_subset: mpath slim
in_subset: value slim
label: 慢性 @zh

in contact with
type: Class
subclass of: physical quality of a process
definition: A structural quality inhering in a bearer by virtue of the bearer's touching another entity.
imported from: pato.owl
has_obo_namespace: quality
has_related_synonym: contiguous
id: PATO:0001961
in_subset: relational slim
in_subset: value slim
label: contact
label: 接触性 @zh

neoplastic
type: Class
subclass of: structure
definition: A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells.
imported from: pato.owl
has_exact_synonym: tumorous
has_obo_namespace: quality
id: PATO:0002011
in_subset: disposition slim
in_subset: mpath slim
in_subset: value slim
label: 肿瘤性 @zh

physical quality of a process
type: Class
subclass of: process quality
imported from: pato.owl
created by: george
creation date: 2009-06-05T09:16:46Z
has_obo_namespace: quality
id: PATO:0002062
in_subset: attribute slim

neoplastic, malignant
type: Class
subclass of: neoplastic
definition: A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize.
imported from: pato.owl
created by: george
creation date: 2009-10-05T12:50:22Z
has_exact_synonym: 恶性 @zh
has_obo_namespace: quality
id: PATO:0002097
in_subset: disposition slim
in_subset: mpath slim
in_subset: value slim
label: 肿瘤性的，恶性 @zh

exposure event or process
type: Class
subclass of: process
example of usage: An exposure event in which a human is exposed to particulate matter in the air. Here the exposure stimulus/stress is the particulate matter, the receptor is the airways and lungs of the human,
example of usage: An exposure event in which a plant is provided with fertilizer. The exposure receptor is the root system of the plant, the stimulus is the fertilizing chemical, the route is via the soil, possibly mediated by symbotic microbes.
definition: A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism.
editor note: This class is intended as a grouping for various domain and species-specific exposure classes. The ExO class http://purl.obolibrary.org/obo/ExO_0000002 'exposure event' assumes that all exposures involve stressors, which limits the applicability of this class to 'positive' exposures, e.g. exposing a plant to beneficial growing conditions.
imported from: OBO Relations Ontology
creator: Chris Mungall
created by: cjm
creation date: 2017-06-05T17:55:39Z

system
type: Class
subclass of: material entity
definition: A material entity consisting of multiple components that are causally integrated.
editor note: May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43
definition editor: Chris Mungall
definition source: http://www.jbiomedsem.com/content/4/1/43
imported from: OBO Relations Ontology

nose
type: Class
subclass of: organism subdivision
subclass of: olfactory organ
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
definition: The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity.
imported from: uberon.owl
external_definition: Organ that is the specialized structure of the face that contains olfactory neurons. The peripheral olfactory organ is paired[ZFA:0000047].
external_definition: a protuberance in vertebrates that houses the nostrils, or nares, which admit and expel air for respiration in conjunction with the mouth. Behind the nose are the olfactory mucosa and the sinuses. Behind the nasal cavity, air next passes through the pharynx, shared with the digestive system, and then into the rest of the respiratory system. In humans, the nose is located centrally on the face; on most other mammals, it is on the upper tip of the snout[WP]. GO: The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)[Wikipedia:Nose].
external_definition: the organ that is specialized for smell and is part of the respiratory system
taxon_notes: the structure of the nose varies across vertebrates. In tetrapods the nose is part of the respiratory system.[PMID:25312359]
database_cross_reference: Nose
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0028429
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181195007
database_cross_reference: BTO:0000840
database_cross_reference: CALOHA:TS-2037
database_cross_reference: EHDAA2:0001274
database_cross_reference: EHDAA:1502
database_cross_reference: EMAPA:16542
database_cross_reference: EV:0100037
database_cross_reference: EV:0100370
database_cross_reference: FMA:46472
database_cross_reference: GAID:77
database_cross_reference: MA:0000281
database_cross_reference: MAT:0000139
database_cross_reference: MESH:D009666
database_cross_reference: MIAA:0000139
database_cross_reference: NCIT:C12756
database_cross_reference: OpenCyc:Mx4rvViCbJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000047
database_cross_reference: UMLS:C0028429
database_cross_reference: ZFA:0000047
database_cross_reference: galen:Nose
has_exact_synonym: nasal sac
has_exact_synonym: nose
has_exact_synonym: peripheral olfactory organ
has_obo_namespace: uberon
has_related_synonym: nasus
has_related_synonym: olfactory apparatus
has_related_synonym: proboInOwlscis
id: UBERON:0000004
in_subset: efo slim
in_subset: major organ
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

zone of skin
type: Class
subclass of: ectoderm-derived structure
subclass of: zone of organ
definition: Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
curator note: Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee
imported from: uberon.owl
homology_notes: (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]
external_ontology_notes: we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive
database_cross_reference: Skin
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/20795001
database_cross_reference: EHDAA2:0001844
database_cross_reference: EHDAA:6530
database_cross_reference: EMAPA:17525
database_cross_reference: EV:0100152
database_cross_reference: FMA:86166
database_cross_reference: GAID:933
database_cross_reference: MA:0000151
database_cross_reference: MAT:0000284
database_cross_reference: MESH:D012867
database_cross_reference: MIAA:0000284
database_cross_reference: OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0000860
has_exact_synonym: portion of skin
has_exact_synonym: region of skin
has_exact_synonym: skin
has_exact_synonym: skin region
has_exact_synonym: skin zone
has_obo_namespace: uberon
id: UBERON:0000014
in_subset: pheno slim
label: zong of skin
label: 皮肤 @zh

sense organ
type: Class
subclass of: organ
definition: An organ that is capable of transducing sensory stimulus to the nervous system.
imported from: uberon.owl
contributor: cmungall
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0935626
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/244485009
database_cross_reference: AEO:0000094
database_cross_reference: BSA:0000121
database_cross_reference: BTO:0000202
database_cross_reference: CALOHA:TS-2043
database_cross_reference: EHDAA2:0001824
database_cross_reference: EHDAA:500
database_cross_reference: EMAPA:35955
database_cross_reference: FBbt:00005155
database_cross_reference: GAID:63
database_cross_reference: HAO:0000930
database_cross_reference: MA:0000017
database_cross_reference: MESH:D012679
database_cross_reference: NCIT:C33224
database_cross_reference: UMLS:C0935626
database_cross_reference: VHOG:0001407
database_cross_reference: WBbt:0006929
has_exact_synonym: organ of sense organ system
has_exact_synonym: organ of sensory organ system
has_exact_synonym: organ of sensory system
has_exact_synonym: sense organ system organ
has_exact_synonym: sensory organ
has_exact_synonym: sensory organ system organ
has_exact_synonym: sensory system organ
has_narrow_synonym: sensillum
has_obo_namespace: uberon
has_related_synonym: Sinnesorgan
has_related_synonym: sensor
id: UBERON:0000020
in_subset: uberon slim

tube
type: Class
subclass of: anatomical conduit
definition: Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.
curator note: not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)
imported from: uberon.owl
has_relational_adjective: tubular
database_cross_reference: galen:Tube
has_exact_synonym: anatomical tube
has_narrow_synonym: duct
has_obo_namespace: uberon
id: UBERON:0000025

head
type: Class
subclass of: subdivision of organism along main body axis
definition: The head is the anterior-most division of the body [GO].
imported from: uberon.owl
external_definition: Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]
external_definition: Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]
homology_notes: Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]
database_cross_reference: Head
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018670
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302548004
database_cross_reference: AAO:0010335
database_cross_reference: AEO:0000106
database_cross_reference: BILA:0000115
database_cross_reference: BIRNLEX:1230
database_cross_reference: BTO:0000282
database_cross_reference: CALOHA:TS-0436
database_cross_reference: EFO:0000964
database_cross_reference: EHDAA2:0003106
database_cross_reference: EMAPA:31858
database_cross_reference: FBbt:00000004
database_cross_reference: FMA:7154
database_cross_reference: GAID:61
database_cross_reference: HAO:0000397
database_cross_reference: MA:0000023
database_cross_reference: MAT:0000294
database_cross_reference: MESH:D006257
database_cross_reference: MIAA:0000294
database_cross_reference: NCIT:C12419
database_cross_reference: OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg
database_cross_reference: OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA
database_cross_reference: SPD:0000016
database_cross_reference: TAO:0001114
database_cross_reference: TGMA:0000002
database_cross_reference: UMLS:C0018670
database_cross_reference: VHOG:0001644
database_cross_reference: WBbt:0005739
database_cross_reference: XAO:0003024
database_cross_reference: ZFA:0001114
database_cross_reference: galen:Head
has_exact_synonym: head (volume)
has_narrow_synonym: adult head
has_obo_namespace: uberon
has_related_synonym: cephalic area
id: UBERON:0000033
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

serous membrane
type: Class
subclass of: multi-tissue structure
subclass of: mesoderm-derived structure
definition: multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.
imported from: uberon.owl
external_definition: A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]
external_definition: a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]
external_ontology_notes: in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA.
contributor: cmungall
database_cross_reference: Serous membrane
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0036760
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362878009
database_cross_reference: FMA:9581
database_cross_reference: GAID:19
database_cross_reference: MESH:D012704
database_cross_reference: NCIT:C13169
database_cross_reference: TAO:0005425
database_cross_reference: UMLS:C0036760
database_cross_reference: ZFA:0005425
has_exact_synonym: tunica serosa
has_exact_synonym: wall of serous sac
has_obo_namespace: uberon
has_related_synonym: serosa
id: UBERON:0000042
in_subset: uberon slim
in_subset: vertebrate core

vessel
type: Class
subclass of: anatomical conduit
definition: A tubular structure that contains, conveys body fluid, such as blood or lymph.
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0000055
in_subset: grouping class
in_subset: pheno slim

duct
type: Class
subclass of: organ subunit
definition: A tubular structure that transports secreted or excreted substances.
imported from: uberon.owl
external_definition: A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171].
external_ontology_notes: Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here.
database_cross_reference: Duct (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0687028
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91726008
database_cross_reference: AAO:0011123
database_cross_reference: FBbt:00100314
database_cross_reference: FMA:30320
database_cross_reference: NCIT:C12948
database_cross_reference: TAO:0005171
database_cross_reference: UMLS:C0687028
database_cross_reference: XAO:0004000
database_cross_reference: ZFA:0005171
database_cross_reference: galen:Duct
has_exact_synonym: anatomical duct
has_narrow_synonym: exocrine duct
has_narrow_synonym: exocrine gland duct
has_obo_namespace: uberon
has_related_synonym: ducts
id: UBERON:0000058
in_subset: grouping class

anatomical structure
type: Class
subclass of: material entity
definition: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
imported from: uberon.owl
database_cross_reference: AnatomicalStructure
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362889002
database_cross_reference: AAO:0010825
database_cross_reference: AEO:0000003
database_cross_reference: BILA:0000003
database_cross_reference: CARO:0000003
database_cross_reference: EHDAA2:0003003
database_cross_reference: EMAPA:0
database_cross_reference: FBbt:00007001
database_cross_reference: FMA:305751
database_cross_reference: FMA:67135
database_cross_reference: GAID:781
database_cross_reference: HAO:0000003
database_cross_reference: MA:0003000
database_cross_reference: MESH:D000825
database_cross_reference: TAO:0000037
database_cross_reference: TGMA:0001823
database_cross_reference: VHOG:0001759
database_cross_reference: XAO:0003000
database_cross_reference: ZFA:0000037
has_exact_synonym: biological structure
has_exact_synonym: connected biological structure
has_obo_namespace: uberon
id: UBERON:0000061
in_subset: upper level

organ
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that performs a specific function or group of functions [WP].
imported from: uberon.owl
external_definition: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
external_ontology_notes: CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4
database_cross_reference: Organ (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0178784
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272625005
database_cross_reference: BIRNLEX:4
database_cross_reference: CARO:0020004
database_cross_reference: EFO:0000634
database_cross_reference: EMAPA:35949
database_cross_reference: ENVO:01000162
database_cross_reference: FMA:67498
database_cross_reference: MA:0003001
database_cross_reference: NCIT:C13018
database_cross_reference: OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0178784
database_cross_reference: WBbt:0003760
has_obo_namespace: uberon
has_related_synonym: anatomical unit
has_related_synonym: body organ
has_related_synonym: element
id: UBERON:0000062
in_subset: upper level

organ subunit
type: Class
subclass of: organ part
definition: A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.
editor note: FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction
imported from: uberon.owl
external_definition: Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball.
external_definition: Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal.
database_cross_reference: FMA:86140
has_obo_namespace: uberon
has_related_synonym: organ region with fixed fiat boundary
has_related_synonym: organ segment
has_related_synonym: segment of organ
id: UBERON:0000063
in_subset: upper level

organ part
type: Class
subclass of: multicellular anatomical structure
definition: A multicellular structure that is a part of an organ.
curator note: currently defined in a very broad sense, may be replaced by more specific classes in the future
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/113343008
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91717005
database_cross_reference: AAO:0011124
database_cross_reference: BIRNLEX:16
database_cross_reference: EFO:0000635
database_cross_reference: FMA:82472
has_exact_synonym: cardinal organ part
has_obo_namespace: uberon
has_related_synonym: regional part of organ
id: UBERON:0000064
in_subset: efo slim
in_subset: non informative
in_subset: upper level

respiratory tract
type: Class
subclass of: respiratory airway
subclass of: endoderm-derived structure
definition: Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361110005
database_cross_reference: EHDAA2:0001606
database_cross_reference: EHDAA:1568
database_cross_reference: EHDAA:2219
database_cross_reference: EMAPA:16737
database_cross_reference: FMA:265130
database_cross_reference: OpenCyc:Mx4rvvM--pwpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0000393
has_obo_namespace: uberon
id: UBERON:0000065

proximo-distal subdivision of respiratory tract
type: Class
subclass of: endoderm-derived structure
subclass of: subdivision of tube
definition: An section of a respiratory tract.
imported from: uberon.owl
external_ontology_notes: MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole
database_cross_reference: EMAPA:16737
database_cross_reference: FMA:45660
database_cross_reference: MA:0000434
has_obo_namespace: uberon
has_related_synonym: respiratory tract
has_related_synonym: subdivision of respiratory tract
id: UBERON:0000072
in_subset: non informative

subdivision of skeletal system
type: Class
subclass of: organ system subdivision
definition: Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.
imported from: uberon.owl
has_alternative_id: UBERON:0010322
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1519343
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/118966000
database_cross_reference: FMA:85544
database_cross_reference: NCIT:C34076
database_cross_reference: UMLS:C1519343
database_cross_reference: galen:ComplexSkeletalStructure
has_exact_synonym: skeletal system subdivision
has_obo_namespace: uberon
has_related_synonym: skeletal system part
id: UBERON:0000075
in_subset: non informative

mixed endoderm/mesoderm-derived structure
type: Class
subclass of: endoderm-derived structure
subclass of: mesoderm-derived structure
definition: An anatomical structure that develops from the endoderm and the mesoderm.
curator note: Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0000077
in_subset: grouping class

neuron projection bundle
type: Class
subclass of: multi cell part structure
definition: A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
imported from: uberon.owl
has_alternative_id: UBERON:0005163
database_cross_reference: CARO:0001001
database_cross_reference: FBbt:00005099
database_cross_reference: NLX:147821
has_exact_synonym: funiculus
has_exact_synonym: nerve fiber bundle
has_exact_synonym: neural fiber bundle
has_obo_namespace: uberon
id: UBERON:0000122

intestine
type: Class
subclass of: subdivision of digestive tract
definition: Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.
editor note: This class is probably too inclusive
imported from: uberon.owl
external_definition: Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]
external_definition: The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
has_relational_adjective: intestinal
taxon_notes: In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type.
database_cross_reference: Intestine
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0021853
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/256876008
database_cross_reference: AAO:0000246
database_cross_reference: ANISEED:1235303
database_cross_reference: BSA:0000093
database_cross_reference: BTO:0000648
database_cross_reference: CALOHA:TS-0490
database_cross_reference: EFO:0000834
database_cross_reference: EMAPA:32874
database_cross_reference: EV:0100071
database_cross_reference: FMA:7199
database_cross_reference: GAID:295
database_cross_reference: MA:0000328
database_cross_reference: MA:0001524
database_cross_reference: MESH:A03.492.411
database_cross_reference: MIAA:0000043
database_cross_reference: NCIT:C12736
database_cross_reference: TAO:0001338
database_cross_reference: UMLS:C0021853
database_cross_reference: VHOG:0000056
database_cross_reference: WBbt:0005772
database_cross_reference: XAO:0000129
database_cross_reference: ZFA:0001338
database_cross_reference: galen:Intestine
has_exact_synonym: bowel
has_obo_namespace: uberon
has_related_synonym: intestinal tract
id: UBERON:0000160
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

pair of lungs
type: Class
subclass of: anatomical collection
definition: The pair of anatomical structures comprised of a left lung and right lung.
imported from: uberon.owl
database_cross_reference: FMA:68877
database_cross_reference: OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA
has_exact_synonym: lungs
has_exact_synonym: lungs pair
has_exact_synonym: pulmones
has_exact_synonym: set of lungs
has_obo_namespace: uberon
id: UBERON:0000170
in_subset: pheno slim

respiration organ
type: Class
subclass of: organ
definition: Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272626006
database_cross_reference: EMAPA:17607
database_cross_reference: SPD:0000428
database_cross_reference: TGMA:0001247
has_exact_synonym: apparatus respiratorius organ
has_exact_synonym: breathing organ
has_exact_synonym: organ of apparatus respiratorius
has_exact_synonym: organ of respiratory system
has_exact_synonym: respiratory organ
has_exact_synonym: respiratory system organ
has_obo_namespace: uberon
has_related_synonym: gas exchange organ
id: UBERON:0000171
in_subset: functional classification
in_subset: organ slim

blood
type: Class
subclass of: haemolymphatic fluid
definition: A fluid that is composed of blood plasma and erythrocytes.
curator note: This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
imported from: uberon.owl
external_definition: A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]
contributor: cmungall
contributor: tmeehan
database_cross_reference: Blood
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0005767
database_cross_reference: AAO:0000046
database_cross_reference: BTO:0000089
database_cross_reference: CALOHA:TS-0079
database_cross_reference: EFO:0000296
database_cross_reference: EHDAA2:0000176
database_cross_reference: EHDAA:418
database_cross_reference: EMAPA:16332
database_cross_reference: ENVO:02000027
database_cross_reference: EV:0100047
database_cross_reference: FMA:9670
database_cross_reference: GAID:965
database_cross_reference: MA:0000059
database_cross_reference: MESH:D001769
database_cross_reference: MIAA:0000315
database_cross_reference: NCIT:C12434
database_cross_reference: OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000007
database_cross_reference: UMLS:C0005767
database_cross_reference: VHOG:0000224
database_cross_reference: XAO:0000124
database_cross_reference: ZFA:0000007
database_cross_reference: galen:Blood
has_exact_synonym: portion of blood
has_exact_synonym: vertebrate blood
has_obo_namespace: uberon
has_related_synonym: whole blood
id: UBERON:0000178
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

haemolymphatic fluid
type: Class
subclass of: bodily fluid
definition: Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.
imported from: uberon.owl
created by: cjm
creation date: 2009-04-08T04:38:19Z
database_cross_reference: CARO:0000081
has_obo_namespace: uberon
has_related_synonym: blood or blood analog
has_related_synonym: circulating fluid
id: UBERON:0000179

breast
type: Class
subclass of: external soft tissue zone
definition: The upper ventral region of the torso of an organism.
imported from: uberon.owl
taxon_notes: The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's.
database_cross_reference: Breast
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0006141
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181131000
database_cross_reference: BTO:0000149
database_cross_reference: CALOHA:TS-2083
database_cross_reference: EV:0100124
database_cross_reference: FMA:9601
database_cross_reference: GAID:33
database_cross_reference: MESH:D001940
database_cross_reference: NCIT:C12971
database_cross_reference: OpenCyc:Mx4rvVjV7ZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0006141
database_cross_reference: galen:Breast
has_exact_synonym: mammary part of chest
has_exact_synonym: mammary region
has_obo_namespace: uberon
has_related_synonym: mamma
id: UBERON:0000310
in_subset: pheno slim

throat
type: Class
subclass of: external soft tissue zone
definition: In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted].
imported from: uberon.owl
has_relational_adjective: gular
taxon_notes: The hyoid bone and the clavicle are the only bones located in the throat of mammals.
database_cross_reference: Throat
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0230069
database_cross_reference: BTO:0000828
database_cross_reference: EMAPA:37973
database_cross_reference: FMA:228738
database_cross_reference: NCIT:C54272
database_cross_reference: OpenCyc:Mx4rwQtO_JwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0230069
has_obo_namespace: uberon
has_related_synonym: gula
id: UBERON:0000341
in_subset: pheno slim
depicted by: Throat:Diagram.png

secretion of exocrine gland
type: Class
subclass of: organism substance
definition: A portion of organism substance that is produced by exocrine glands.
imported from: uberon.owl
external_ontology_notes: BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions
has_alternative_id: UBERON:0006540
has_broad_synonym: secretion
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1516992
database_cross_reference: AEO:0001005
database_cross_reference: BTO:0002977
database_cross_reference: BTO:0002979
database_cross_reference: EMAPA:36535
database_cross_reference: FMA:9675
database_cross_reference: MA:0002504
database_cross_reference: MESH:D012634
database_cross_reference: NCIT:C34062
database_cross_reference: UMLS:C1516992
database_cross_reference: galen:Secretion
has_exact_synonym: bodily secretion
has_exact_synonym: exocrine gland fluid/secretion
has_exact_synonym: secreted substance
has_obo_namespace: uberon
has_related_synonym: exocrine gland fluid
has_related_synonym: exocrine gland fluid or secretion
has_related_synonym: exocrine gland secretion
has_related_synonym: external secretion
id: UBERON:0000456

organism substance
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
imported from: uberon.owl
database_cross_reference: AAO:0010839
database_cross_reference: AEO:0000004
database_cross_reference: BILA:0000004
database_cross_reference: CALOHA:TS-2101
database_cross_reference: CARO:0000004
database_cross_reference: EHDAA2:0003004
database_cross_reference: EMAPA:35178
database_cross_reference: FBbt:00007019
database_cross_reference: FMA:9669
database_cross_reference: HAO:0000004
database_cross_reference: MA:0002450
database_cross_reference: NCIT:C13236
database_cross_reference: SPD:0000008
database_cross_reference: TAO:0001487
database_cross_reference: TGMA:0001824
database_cross_reference: VHOG:0001726
database_cross_reference: XAO:0004001
database_cross_reference: ZFA:0001487
database_cross_reference: galen:BodySubstance
has_exact_synonym: body fluid or substance
has_exact_synonym: body substance
has_exact_synonym: organism substance
has_exact_synonym: portion of body substance
has_exact_synonym: portion of organism substance
has_obo_namespace: uberon
id: UBERON:0000463
in_subset: pheno slim
in_subset: upper level

material anatomical entity
type: Class
subclass of: anatomical entity
definition: Anatomical entity that has mass.
imported from: uberon.owl
database_cross_reference: AAO:0010264
database_cross_reference: AEO:0000006
database_cross_reference: BILA:0000006
database_cross_reference: CARO:0000006
database_cross_reference: EHDAA2:0003006
database_cross_reference: FBbt:00007016
database_cross_reference: FMA:67165
database_cross_reference: HAO:0000006
database_cross_reference: TAO:0001836
database_cross_reference: TGMA:0001826
database_cross_reference: VHOG:0001721
has_obo_namespace: uberon
id: UBERON:0000465
in_subset: upper level

anatomical system
type: Class
subclass of: anatomical structure
definition: Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
imported from: uberon.owl
has_broad_synonym: system
database_cross_reference: Organ system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0460002
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278195005
database_cross_reference: AAO:0000007
database_cross_reference: AEO:0000011
database_cross_reference: BILA:0000011
database_cross_reference: BIRNLEX:14
database_cross_reference: BSA:0000049
database_cross_reference: CALOHA:TS-2088
database_cross_reference: CARO:0000011
database_cross_reference: EHDAA2:0003011
database_cross_reference: EHDAA:392
database_cross_reference: EMAPA:16103
database_cross_reference: EV:0100000
database_cross_reference: FBbt:00004856
database_cross_reference: FMA:7149
database_cross_reference: HAO:0000011
database_cross_reference: MA:0000003
database_cross_reference: NCIT:C12919
database_cross_reference: OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ
database_cross_reference: TAO:0001439
database_cross_reference: TGMA:0001831
database_cross_reference: UMLS:C0460002
database_cross_reference: VHOG:0001725
database_cross_reference: WBbt:0005746
database_cross_reference: WBbt:0005763
database_cross_reference: XAO:0003002
database_cross_reference: ZFA:0001439
database_cross_reference: galen:AnatomicalSystem
has_exact_synonym: body system
has_exact_synonym: connected anatomical system
has_exact_synonym: organ system
has_obo_namespace: uberon
has_related_synonym: anatomical systems
id: UBERON:0000467
in_subset: pheno slim
in_subset: uberon slim
in_subset: upper level

multicellular organism
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that is an individual member of a species and consists of more than one cell.
editor note: TODO - split body and mc organism? body continues after death stage
imported from: uberon.owl
has_relational_adjective: organismal
has_broad_synonym: organism
database_cross_reference: Multi-cellular organism
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/243928005
database_cross_reference: AAO:0010026
database_cross_reference: AEO:0000191
database_cross_reference: BILA:0000012
database_cross_reference: BIRNLEX:18
database_cross_reference: BSA:0000038
database_cross_reference: BTO:0000042
database_cross_reference: CARO:0000012
database_cross_reference: EFO:0002906
database_cross_reference: EHDAA2:0003103
database_cross_reference: EHDAA2:0003191
database_cross_reference: EHDAA:1
database_cross_reference: EMAPA:25765
database_cross_reference: EV:0100016
database_cross_reference: FBbt:00000001
database_cross_reference: FMA:256135
database_cross_reference: HAO:0000012
database_cross_reference: NCIT:C13041
database_cross_reference: TADS:0000001
database_cross_reference: TAO:0001094
database_cross_reference: TGMA:0001832
database_cross_reference: VHOG:0000671
database_cross_reference: WBbt:0007833
database_cross_reference: XAO:0003004
database_cross_reference: ZFA:0001094
database_cross_reference: galen:Organism
database_cross_reference: ncithesaurus:Whole_Organism
has_exact_synonym: multi-cellular organism
has_narrow_synonym: animal
has_obo_namespace: uberon
has_related_synonym: Koerper
has_related_synonym: body
has_related_synonym: whole body
has_related_synonym: whole organism
id: UBERON:0000468
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: upper level

organism subdivision
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.
editor note: Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency
imported from: uberon.owl
database_cross_reference: Body part
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0229962
database_cross_reference: AAO:0010053
database_cross_reference: AEO:0000032
database_cross_reference: BILA:0000032
database_cross_reference: BIRNLEX:7
database_cross_reference: CALOHA:TS-2084
database_cross_reference: CARO:0000032
database_cross_reference: EFO:0000808
database_cross_reference: EHDAA2:0003032
database_cross_reference: EMAPA:36031
database_cross_reference: FBbt:00007009
database_cross_reference: FMA:7153
database_cross_reference: HAO:0000032
database_cross_reference: MA:0002433
database_cross_reference: MAT:0000293
database_cross_reference: MESH:D001829
database_cross_reference: MIAA:0000293
database_cross_reference: NCIT:C32221
database_cross_reference: OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001308
database_cross_reference: TGMA:0001840
database_cross_reference: UMLS:C0229962
database_cross_reference: VHOG:0001758
database_cross_reference: XAO:0003013
database_cross_reference: ZFA:0001308
database_cross_reference: galen:BodyPart
has_exact_synonym: anatomic region
has_obo_namespace: uberon
has_related_synonym: body part
has_related_synonym: body region
has_related_synonym: cardinal body part
id: UBERON:0000475
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: upper level

anatomical cluster
type: Class
subclass of: anatomical entity
definition: Anatomical group that has its parts adjacent to one another.
editor note: Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3]
imported from: uberon.owl
database_cross_reference: AAO:0010009
database_cross_reference: AEO:0000041
database_cross_reference: BILA:0000041
database_cross_reference: CARO:0000041
database_cross_reference: EHDAA2:0003041
database_cross_reference: FBbt:00007277
database_cross_reference: FMA:49443
database_cross_reference: HAO:0000041
database_cross_reference: TADS:0000605
database_cross_reference: TAO:0001478
database_cross_reference: TGMA:0001842
database_cross_reference: VHOG:0001737
database_cross_reference: XAO:0003160
database_cross_reference: ZFA:0001478
has_obo_namespace: uberon
id: UBERON:0000477
in_subset: upper level

tissue
type: Class
subclass of: multicellular anatomical structure
definition: Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
editor note: changed label and definition to reflect CARO2
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0040300
database_cross_reference: AAO:0000607
database_cross_reference: AAO:0010054
database_cross_reference: AEO:0000043
database_cross_reference: BILA:0000043
database_cross_reference: BIRNLEX:19
database_cross_reference: CALOHA:TS-2090
database_cross_reference: CARO:0000043
database_cross_reference: EHDAA2:0003043
database_cross_reference: EMAPA:35868
database_cross_reference: FBbt:00007003
database_cross_reference: FMA:9637
database_cross_reference: HAO:0000043
database_cross_reference: MA:0003002
database_cross_reference: MESH:D014024
database_cross_reference: NCIT:C12801
database_cross_reference: TAO:0001477
database_cross_reference: TGMA:0001844
database_cross_reference: UMLS:C0040300
database_cross_reference: VHOG:0001757
database_cross_reference: WBbt:0005729
database_cross_reference: XAO:0003040
database_cross_reference: ZFA:0001477
database_cross_reference: galen:Tissue
has_exact_synonym: portion of tissue
has_exact_synonym: tissue portion
has_narrow_synonym: simple tissue
has_obo_namespace: uberon
id: UBERON:0000479
in_subset: pheno slim
in_subset: upper level

multi-tissue structure
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
imported from: uberon.owl
database_cross_reference: AAO:0010048
database_cross_reference: AEO:0000055
database_cross_reference: BILA:0000055
database_cross_reference: CARO:0000055
database_cross_reference: EHDAA2:0003055
database_cross_reference: FBbt:00007010
database_cross_reference: HAO:0000055
database_cross_reference: TAO:0001488
database_cross_reference: TGMA:0001847
database_cross_reference: VHOG:0001762
database_cross_reference: XAO:0003037
database_cross_reference: ZFA:0001488
has_obo_namespace: uberon
has_related_synonym: multi-tissue structures
id: UBERON:0000481
in_subset: upper level

cavitated compound organ
type: Class
subclass of: compound organ
definition: Compound organ that contains one or more macroscopic anatomical spaces.
curator note: this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future
imported from: uberon.owl
database_cross_reference: AAO:0010016
database_cross_reference: AEO:0000072
database_cross_reference: BILA:0000072
database_cross_reference: CARO:0000072
database_cross_reference: EHDAA2:0003072
database_cross_reference: FMA:55671
database_cross_reference: HAO:0000072
database_cross_reference: TAO:0001490
database_cross_reference: TGMA:0001857
database_cross_reference: VHOG:0001730
database_cross_reference: XAO:0003165
database_cross_reference: ZFA:0001490
has_exact_synonym: cavitated organ
has_obo_namespace: uberon
has_related_synonym: cavitated compound organs
id: UBERON:0000489
in_subset: organ slim
in_subset: upper level

stomach
type: Class
subclass of: subdivision of digestive tract
subclass of: food storage organ
definition: An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.
imported from: uberon.owl
external_definition: Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]
homology_notes: It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]
taxon_notes: We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa
database_cross_reference: Stomach
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0038351
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181246003
database_cross_reference: AAO:0000579
database_cross_reference: ANISEED:1235297
database_cross_reference: BTO:0001307
database_cross_reference: CALOHA:TS-0980
database_cross_reference: EFO:0000837
database_cross_reference: EHDAA2:0001915
database_cross_reference: EHDAA:2993
database_cross_reference: EMAPA:17021
database_cross_reference: EV:0100070
database_cross_reference: FMA:7148
database_cross_reference: GAID:293
database_cross_reference: MA:0000353
database_cross_reference: MAT:0000051
database_cross_reference: MESH:A03.492.766
database_cross_reference: MIAA:0000051
database_cross_reference: NCIT:C12391
database_cross_reference: OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0002121
database_cross_reference: UMLS:C0038351
database_cross_reference: VHOG:0000408
database_cross_reference: XAO:0000128
database_cross_reference: galen:Stomach
has_narrow_synonym: stomach chamber
has_obo_namespace: uberon
has_related_synonym: anterior intestine
has_related_synonym: gaster
has_related_synonym: mesenteron
has_related_synonym: ventriculus
id: UBERON:0000945
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core
depicted by: Stomach:diagram.svg

heart
type: Class
subclass of: mesoderm-derived structure
subclass of: thoracic segment organ
subclass of: primary circulatory organ
subclass of: structure with developmental contribution from neural crest
definition: A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.
imported from: uberon.owl
external_definition: Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]
external_definition: Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]
axiom_lost_from_external_ontology: relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]
homology_notes: As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]
has_relational_adjective: cardiac
database_cross_reference: Heart
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018787
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302509004
database_cross_reference: AAO:0010210
database_cross_reference: BILA:0000020
database_cross_reference: BTO:0000562
database_cross_reference: CALOHA:TS-0445
database_cross_reference: EFO:0000815
database_cross_reference: EHDAA2:0000738
database_cross_reference: EHDAA:420
database_cross_reference: EMAPA:16105
database_cross_reference: EV:0100018
database_cross_reference: FMA:7088
database_cross_reference: GAID:174
database_cross_reference: MA:0000072
database_cross_reference: MAT:0000036
database_cross_reference: MESH:D006321
database_cross_reference: MIAA:0000036
database_cross_reference: NCIT:C12727
database_cross_reference: OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000114
database_cross_reference: UMLS:C0018787
database_cross_reference: VHOG:0000276
database_cross_reference: XAO:0000064
database_cross_reference: ZFA:0000114
database_cross_reference: galen:Heart
has_exact_synonym: chambered heart
has_exact_synonym: vertebrate heart
has_narrow_synonym: branchial heart
has_obo_namespace: uberon
has_related_synonym: Herz@de
has_related_synonym: cardium
id: UBERON:0000948
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core
comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706

brain
type: Class
subclass of: organ
subclass of: ectoderm-derived structure
definition: The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
editor note: requires review for applicability to invertebrate structures, e.g. synganglion
imported from: uberon.owl
external_definition: Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]
external_definition: Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]
external_definition: The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]
contributor: cmungall
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Brain
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0006104
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1269537
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/258335003
database_cross_reference: AAO:0010478
database_cross_reference: ABA:Brain
database_cross_reference: BAMS:Br
database_cross_reference: BAMS:Brain
database_cross_reference: BILA:0000135
database_cross_reference: BIRNLEX:796
database_cross_reference: BTO:0000142
database_cross_reference: CALOHA:TS-0095
database_cross_reference: DHBA:10155
database_cross_reference: EFO:0000302
database_cross_reference: EHDAA2:0000183
database_cross_reference: EHDAA:2641
database_cross_reference: EHDAA:6485
database_cross_reference: EMAPA:16894
database_cross_reference: EV:0100164
database_cross_reference: FBbt:00005095
database_cross_reference: FMA:50801
database_cross_reference: GAID:571
database_cross_reference: HBA:4005
database_cross_reference: MA:0000168
database_cross_reference: MAT:0000098
database_cross_reference: MBA:8
database_cross_reference: MBA:997
database_cross_reference: MESH:D001921
database_cross_reference: MIAA:0000098
database_cross_reference: NCIT:C12439
database_cross_reference: OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA
database_cross_reference: PBA:3999
database_cross_reference: TAO:0000008
database_cross_reference: UMLS:C0006104
database_cross_reference: UMLS:C1269537
database_cross_reference: VHOG:0000157
database_cross_reference: XAO:0000010
database_cross_reference: ZFA:0000008
database_cross_reference: galen:Brain
has_obo_namespace: uberon
has_related_synonym: encephalon
has_related_synonym: suprasegmental levels of nervous system
has_related_synonym: suprasegmental structures
has_related_synonym: synganglion
has_related_synonym: the brain
id: UBERON:0000955
in_subset: cumbo
in_subset: efo slim
in_subset: major organ
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

eye
type: Class
subclass of: sense organ
definition: An organ that detects light.
curator note: This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)
imported from: uberon.owl
has_relational_adjective: ocular
has_relational_adjective: optic
structure_notes: Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva,
database_cross_reference: Eye
database_cross_reference: BILA:0000017
database_cross_reference: BTO:0000439
database_cross_reference: CALOHA:TS-0309
database_cross_reference: EFO:0000827
database_cross_reference: EV:0100336
database_cross_reference: FBbt:00005162
database_cross_reference: GAID:69
database_cross_reference: MAT:0000140
database_cross_reference: MESH:D005123
database_cross_reference: MIAA:0000140
database_cross_reference: OpenCyc:Mx4rvViTvpwpEbGdrcN5Y29ycA
has_obo_namespace: uberon
has_related_synonym: light-detecting organ
has_related_synonym: visual apparatus
id: UBERON:0000970
in_subset: efo slim
in_subset: functional classification
in_subset: major organ
in_subset: organ slim
in_subset: uberon slim

pleura
type: Class
subclass of: serous membrane
subclass of: mixed endoderm/mesoderm-derived structure
definition: The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).
imported from: uberon.owl
present_in_taxon: NCBITaxon 8782
external_definition: The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]
has_relational_adjective: pleural
external_ontology_notes: In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86
database_cross_reference: Pleura
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0032225
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181609007
database_cross_reference: BTO:0001791
database_cross_reference: CALOHA:TS-2081
database_cross_reference: EFO:0001980
database_cross_reference: EMAPA:16775
database_cross_reference: EV:0100044
database_cross_reference: FMA:9583
database_cross_reference: GAID:360
database_cross_reference: MA:0000433
database_cross_reference: MESH:D010994
database_cross_reference: NCIT:C12469
database_cross_reference: OpenCyc:Mx4rv3zwLZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0032225
database_cross_reference: VHOG:0000394
has_exact_synonym: wall of pleural sac
has_obo_namespace: uberon
has_related_synonym: pleura
has_related_synonym: pleural tissue
id: UBERON:0000977
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim

leg
type: Class
subclass of: multi-limb segment region
subclass of: lower limb segment
definition: The portion of the hindlimb that contains both the stylopod and zeugopod.
imported from: uberon.owl
homology_notes: Most anatomists now agree that the three proximal bones of the tetrapod limbs are homologous to the two or three proximal elements of the paired fin skeleton of other sarcopterygians, that is the humerus-femur, radius-tibia, and ulna-fibula.[well established][VHOG]
terminology_notes: The term leg can mean: [1] an appendage on which an animal walks [2] the entire hindlimb of a tetrapod [3] the segment of a human leg between knee and ankle (cf FMA) [4] the region of a hindlimb include the stylopod and zeugopod, but excluding the autopod. We define this class as [4], and thus 'leg' is compltely analagous to 'arm'. For [1], see the class 'locomotive weight-bearing appendage'. For [2] we use 'hindlimb'. For
database_cross_reference: Limb
database_cross_reference: BTO:0000721
database_cross_reference: CALOHA:TS-2206
database_cross_reference: EFO:0001411
database_cross_reference: EHDAA2:0000972
database_cross_reference: EHDAA:5151
database_cross_reference: EHDAA:6176
database_cross_reference: EHDAA:8289
database_cross_reference: EMAPA:17489
database_cross_reference: GAID:49
database_cross_reference: MA:0000047
database_cross_reference: MESH:D035002
database_cross_reference: OpenCyc:Mx4rvViYzZwpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0000345
has_exact_synonym: tetrapod leg
has_obo_namespace: uberon
has_related_synonym: lower extremity
id: UBERON:0000978
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
comment: we use the less open to misinterpretation 'hindlimb zeugopod'. Editor note: currently declared as overlapping foot, as AOs disagree over whether some ankle parts are in the leg or foot

skeletal joint
type: Class
subclass of: articulation
definition: Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].
imported from: uberon.owl
external_definition: Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]
external_definition: Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]
has_broad_synonym: articulation
has_broad_synonym: joint
database_cross_reference: Joint
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0022417
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302536002
database_cross_reference: AEO:0000182
database_cross_reference: BTO:0001686
database_cross_reference: CALOHA:TS-2023
database_cross_reference: EFO:0000948
database_cross_reference: EMAPA:35456
database_cross_reference: FMA:7490
database_cross_reference: GAID:102
database_cross_reference: MA:0000319
database_cross_reference: MAT:0000188
database_cross_reference: MESH:D007596
database_cross_reference: MIAA:0000188
database_cross_reference: NCIT:C13044
database_cross_reference: OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA
database_cross_reference: RETIRED_EHDAA2:0003182
database_cross_reference: TAO:0000367
database_cross_reference: UMLS:C0022417
database_cross_reference: VHOG:0001276
database_cross_reference: VSAO:0000101
database_cross_reference: XAO:0000171
database_cross_reference: ZFA:0001596
database_cross_reference: galen:Joint
has_obo_namespace: uberon
has_related_synonym: articular joint
has_related_synonym: joints
id: UBERON:0000982
in_subset: efo slim
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

uterus
type: Class
subclass of: subdivision of oviduct
definition: the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth
imported from: uberon.owl
external_definition: The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]
homology_notes: An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]
has_relational_adjective: uterine
taxon_notes: Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle 'vagina' which functions as the birth canal. Marsupial embryos form a choriovitelline 'placenta' (which can be thought of as something between a monotreme egg and a 'true' placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream.
development_notes: Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused [Wikipedia:Uterus]
database_cross_reference: Uterus
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0042149
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181452004
database_cross_reference: BTO:0001424
database_cross_reference: CALOHA:TS-1102
database_cross_reference: EFO:0000975
database_cross_reference: EMAPA:29915
database_cross_reference: EV:0100113
database_cross_reference: FMA:17558
database_cross_reference: GAID:172
database_cross_reference: MA:0000389
database_cross_reference: MAT:0000127
database_cross_reference: MESH:D014599
database_cross_reference: MIAA:0000127
database_cross_reference: NCIT:C12405
database_cross_reference: OpenCyc:Mx4rvViojJwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0042149
database_cross_reference: VHOG:0001137
database_cross_reference: galen:Uterus
has_obo_namespace: uberon
id: UBERON:0000995
in_subset: efo slim
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
depicted by: Female:anatomy.png

respiratory system
type: Class
subclass of: anatomical system
definition: Functional system which consists of structures involved in respiration.
imported from: uberon.owl
external_definition: The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]
homology_notes: There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]
database_cross_reference: Respiratory system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0035237
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278197002
database_cross_reference: AAO:0000541
database_cross_reference: BTO:0000203
database_cross_reference: CALOHA:TS-1319
database_cross_reference: EFO:0000804
database_cross_reference: EHDAA2:0001604
database_cross_reference: EHDAA:2203
database_cross_reference: EMAPA:16727
database_cross_reference: EV:0100036
database_cross_reference: FMA:7158
database_cross_reference: GAID:78
database_cross_reference: MA:0000327
database_cross_reference: MAT:0000030
database_cross_reference: MESH:D012137
database_cross_reference: MIAA:0000030
database_cross_reference: NCIT:C12779
database_cross_reference: OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000272
database_cross_reference: UMLS:C0035237
database_cross_reference: VHOG:0000202
database_cross_reference: XAO:0000117
database_cross_reference: ZFA:0000272
has_exact_synonym: apparatus respiratorius
has_exact_synonym: respiratory system
has_obo_namespace: uberon
has_related_synonym: Atmungssystem
has_related_synonym: apparatus respiratorius
has_related_synonym: systema respiratorium
id: UBERON:0001004
in_subset: efo slim
in_subset: functional classification
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

respiratory airway
type: Class
subclass of: compound organ
subclass of: anatomical conduit
definition: An airway through which respiratory air passes in organisms.
curator note: This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends
imported from: uberon.owl
has_broad_synonym: airway
has_broad_synonym: airways
database_cross_reference: Trachea
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361380005
database_cross_reference: FMA:265130
has_obo_namespace: uberon
id: UBERON:0001005
in_subset: grouping class
in_subset: uberon slim

digestive system
type: Class
subclass of: anatomical system
definition: Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
imported from: uberon.owl
external_definition: An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]
has_relational_adjective: digestive
external_ontology_notes: many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class
database_cross_reference: Digestive system
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278859004
database_cross_reference: AAO:0000129
database_cross_reference: BILA:0000082
database_cross_reference: BTO:0000058
database_cross_reference: CALOHA:TS-1293
database_cross_reference: EFO:0000793
database_cross_reference: EV:0100056
database_cross_reference: FBbt:00005055
database_cross_reference: FMA:7152
database_cross_reference: GAID:278
database_cross_reference: MA:0002431
database_cross_reference: MAT:0000018
database_cross_reference: MESH:D004064
database_cross_reference: MIAA:0000018
database_cross_reference: TADS:0000170
database_cross_reference: TAO:0000339
database_cross_reference: WBbt:0005748
database_cross_reference: XAO:0000125
database_cross_reference: ZFA:0000339
database_cross_reference: galen:DigestiveSystem
database_cross_reference: ncithesaurus:Digestive_System
has_obo_namespace: uberon
has_related_synonym: alimentary system
has_related_synonym: alimentary tract
has_related_synonym: gastrointestinal system
has_related_synonym: gut
id: UBERON:0001007
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

circulatory system
type: Class
subclass of: anatomical system
definition: organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].
curator note: the cardiovascular system and the lymphatic system are parts of the circulatory system
imported from: uberon.owl
dubious_for_taxon: NCBITaxon 6231
external_definition: Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]
homology_notes: We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]
database_cross_reference: Circulatory system
database_cross_reference: AAO:0000959
database_cross_reference: CALOHA:TS-2103
database_cross_reference: FBbt:00005057
database_cross_reference: OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA
database_cross_reference: VHOG:0001248
has_obo_namespace: uberon
has_related_synonym: systema cardiovasculare
id: UBERON:0001009
in_subset: uberon slim

nervous system
type: Class
subclass of: anatomical system
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
imported from: uberon.owl
external_definition: A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]
homology_notes: Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]
has_relational_adjective: nervous
has_relational_adjective: neural
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: Nervous system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0027763
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278196006
database_cross_reference: AAO:0000324
database_cross_reference: BILA:0000079
database_cross_reference: BIRNLEX:844
database_cross_reference: BTO:0001484
database_cross_reference: CALOHA:TS-1313
database_cross_reference: EFO:0000802
database_cross_reference: EHDAA2:0001246
database_cross_reference: EHDAA:826
database_cross_reference: EMAPA:16469
database_cross_reference: EV:0100162
database_cross_reference: FBbt:00005093
database_cross_reference: FMA:7157
database_cross_reference: GAID:466
database_cross_reference: MA:0000016
database_cross_reference: MAT:0000026
database_cross_reference: MESH:D009420
database_cross_reference: MIAA:0000026
database_cross_reference: NCIT:C12755
database_cross_reference: OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000396
database_cross_reference: UMLS:C0027763
database_cross_reference: VHOG:0000402
database_cross_reference: WBbt:0005735
database_cross_reference: XAO:0000177
database_cross_reference: ZFA:0000396
has_exact_synonym: neurological system
has_narrow_synonym: nerve net
has_obo_namespace: uberon
has_related_synonym: systema nervosum
id: UBERON:0001016
in_subset: cumbo
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

axon tract
type: Class
subclass of: neuron projection bundle
subclass of: central nervous system cell part cluster
definition: A group of axons linking two or more neuropils and having a common origin, termination[FBbt].
imported from: uberon.owl
external_definition: White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. (CUMBO)
database_cross_reference: BIRNLEX:1649
database_cross_reference: EV:0100304
database_cross_reference: FBbt:00005100
database_cross_reference: FMA:83847
database_cross_reference: NLX:147822
has_exact_synonym: axonal tract
has_exact_synonym: neuraxis tract
has_exact_synonym: tract of neuraxis
has_narrow_synonym: nerve tract
has_obo_namespace: uberon
has_related_synonym: nerve tract
has_related_synonym: tract
id: UBERON:0001018
in_subset: cumbo
in_subset: pheno slim
comment: WP says this is the analog of peripheral nerves in CNS.

esophagus
type: Class
subclass of: subdivision of digestive tract
subclass of: thoracic cavity element
subclass of: digestive system element
definition: Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).
imported from: uberon.owl
external_definition: Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]
homology_notes: The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]
has_relational_adjective: esophageal
external_ontology_notes: esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)
database_cross_reference: Esophagus
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014876
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181245004
database_cross_reference: AAO:0000145
database_cross_reference: ANISEED:1235301
database_cross_reference: BTO:0000959
database_cross_reference: CALOHA:TS-0700
database_cross_reference: EFO:0000835
database_cross_reference: EHDAA2:0001285
database_cross_reference: EHDAA:2937
database_cross_reference: EMAPA:16833
database_cross_reference: EV:0100069
database_cross_reference: FMA:7131
database_cross_reference: GAID:291
database_cross_reference: MA:0000352
database_cross_reference: MAT:0000048
database_cross_reference: MESH:A03.365
database_cross_reference: MIAA:0000048
database_cross_reference: NCIT:C12389
database_cross_reference: OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000204
database_cross_reference: UMLS:C0014876
database_cross_reference: VHOG:0000450
database_cross_reference: XAO:0000127
database_cross_reference: ZFA:0000204
database_cross_reference: galen:Esophagus
has_exact_synonym: gullet
has_exact_synonym: oesophagus
has_obo_namespace: uberon
id: UBERON:0001043
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

anatomical entity
type: Class
subclass of: material entity
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1515976
database_cross_reference: AAO:0010841
database_cross_reference: AEO:0000000
database_cross_reference: BILA:0000000
database_cross_reference: BIRNLEX:6
database_cross_reference: CARO:0000000
database_cross_reference: EHDAA2:0002229
database_cross_reference: FBbt:10000000
database_cross_reference: FBbt_root:00000000
database_cross_reference: FMA:62955
database_cross_reference: HAO:0000000
database_cross_reference: MA:0000001
database_cross_reference: NCIT:C12219
database_cross_reference: TAO:0100000
database_cross_reference: TGMA:0001822
database_cross_reference: UMLS:C1515976
database_cross_reference: WBbt:0000100
database_cross_reference: XAO:0000000
database_cross_reference: ZFA:0100000
has_obo_namespace: uberon
id: UBERON:0001062
in_subset: upper level

skin of head
type: Class
subclass of: head or neck skin
definition: A zone of skin that is part of a head [Automatically generated definition].
editor note: TODO - distinguish between entire skin of region and arbitrary zone of skin on region
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0205029
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181484006
database_cross_reference: FMA:12166
database_cross_reference: FMA:24756
database_cross_reference: MA:0000582
database_cross_reference: NCIT:C52757
database_cross_reference: UMLS:C0205029
has_exact_synonym: adult head zone of skin
has_exact_synonym: head skin
has_exact_synonym: head zone of skin
has_exact_synonym: zone of skin of adult head
has_exact_synonym: zone of skin of head
has_obo_namespace: uberon
id: UBERON:0001084

sweat
type: Class
subclass of: secretion of exocrine gland
subclass of: bodily fluid
definition: Secretion produced by a sweat gland.
imported from: uberon.owl
database_cross_reference: Sweat
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0038984
database_cross_reference: BTO:0001254
database_cross_reference: ENVO:02000025
database_cross_reference: FMA:12275
database_cross_reference: GAID:1172
database_cross_reference: MA:0002539
database_cross_reference: MESH:D013542
database_cross_reference: NCIT:C13280
database_cross_reference: OpenCyc:Mx4rvVjJtZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0038984
has_obo_namespace: uberon
has_related_synonym: skin exudate
id: UBERON:0001089
in_subset: pheno slim
in_subset: uberon slim

smooth muscle tissue
type: Class
subclass of: muscle tissue
definition: Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].
imported from: uberon.owl
external_definition: A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO]
external_definition: Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO]
homology_notes: (...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG]
terminology_notes: GO uses visceral and smooth interchangeably. However visceral can also be used in the sense of the viscera. Many fly annotations to smooth muscle terms. If we want to be inclusive of insects have to have a general definition of tissue that includes cells.
database_cross_reference: Smooth muscle tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1267092
database_cross_reference: AAO:0010244
database_cross_reference: AEO:0000141
database_cross_reference: BTO:0001260
database_cross_reference: CALOHA:TS-0943
database_cross_reference: EFO:0000889
database_cross_reference: EHDAA2:0003141
database_cross_reference: EMAPA:32717
database_cross_reference: EV:0100378
database_cross_reference: FBbt:00003525
database_cross_reference: FMA:14070
database_cross_reference: GAID:167
database_cross_reference: MA:0000166
database_cross_reference: MAT:0000303
database_cross_reference: MESH:D009130
database_cross_reference: MIAA:0000303
database_cross_reference: NCIT:C12437
database_cross_reference: OpenCyc:Mx4rvvSS3pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0005274
database_cross_reference: UMLS:C1267092
database_cross_reference: VHOG:0001246
database_cross_reference: WBbt:0005781
database_cross_reference: XAO:0000175
database_cross_reference: ZFA:0005274
database_cross_reference: galen:SmoothMuscle
database_cross_reference: galen:SmoothMuscleTissue
has_exact_synonym: involuntary muscle
has_exact_synonym: non-striated muscle
has_exact_synonym: smooth muscle
has_exact_synonym: textus muscularis nonstriatus
has_narrow_synonym: visceral muscle
has_narrow_synonym: visceral muscle tissue
has_obo_namespace: uberon
has_related_synonym: textus muscularis levis; textus muscularis nonstriatus
id: UBERON:0001135
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core
depicted by: Glatte:Muskelzellen.jpg

dorsum
type: Class
subclass of: organism subdivision
definition: A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..
imported from: uberon.owl
has_relational_adjective: dorsal
taxon_notes: In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body
database_cross_reference: Dorsum (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0004600
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/123961009
database_cross_reference: BTO:0001713
database_cross_reference: CALOHA:TS-2223
database_cross_reference: EFO:0001405
database_cross_reference: FMA:14181
database_cross_reference: GAID:30
database_cross_reference: MESH:A01.176
database_cross_reference: NCIT:C13062
database_cross_reference: OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0004600
database_cross_reference: galen:Back
has_exact_synonym: back
has_exact_synonym: back of body proper
has_exact_synonym: dorsal part of organism
has_obo_namespace: uberon
id: UBERON:0001137
in_subset: efo slim
in_subset: uberon slim

urinary bladder
type: Class
subclass of: viscus
subclass of: mesoderm-derived structure
subclass of: bladder organ
definition: distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].
imported from: uberon.owl
external_definition: A saccular organ in which urine accumulates before discharge from the body. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]
external_definition: Anatomical structure which consists of a membranous sac used to temporarily store urine until it is excreted from the body.[AAO]
homology_notes: In tetrapods, the urinary bladder arises as an outpocketing of the cloaca. (...) The tetrapod urinary bladder appears first among amphibians and is present in Sphenodon, turtles, most lizards, ostriches among birds, and all mammals.[well established][VHOG]
has_relational_adjective: vesical
taxon_notes: The urinary bladder evolved in tetrapods. Birds to not possess a true urinary bladder, although Palaeognathae have an undifferentiated cloacal outpocketing that serves a similar function[https://github.com/obophenotype/uberon/issues/454]
has_broad_synonym: bladder
database_cross_reference: Urinary bladder
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0005682
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/302512001
database_cross_reference: AAO:0000623
database_cross_reference: BTO:0001418
database_cross_reference: CALOHA:TS-1090
database_cross_reference: EFO:0000290
database_cross_reference: EHDAA2:0000174
database_cross_reference: EHDAA:9328
database_cross_reference: EMAPA:18321
database_cross_reference: EV:0100098
database_cross_reference: FMA:15900
database_cross_reference: GAID:0000004
database_cross_reference: MA:0000380
database_cross_reference: MAT:0000122
database_cross_reference: MESH:A05.810.161
database_cross_reference: MIAA:0000122
database_cross_reference: NCIT:C12414
database_cross_reference: OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0005682
database_cross_reference: VHOG:0000740
database_cross_reference: XAO:0000154
database_cross_reference: galen:UrinaryBladder
has_exact_synonym: vesica urinaria
has_obo_namespace: uberon
has_related_synonym: urocyst
has_related_synonym: vesica
id: UBERON:0001255
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
depicted by: Urinary:system.svg

pancreas
type: Class
subclass of: viscus
definition: An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO].
imported from: uberon.owl
external_definition: Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]
homology_notes: In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]
has_relational_adjective: pancreatic
taxon_notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52)
taxon_notes: The zebrafish does not have a discrete pancreas. Exocrine pancreatic tissue can be found scattered along the intestinal tract. The acinar structure of the exocrine pancreas is very similar to that of mammals and comprises cells with a very dark, basophilic cytoplasm
function_notes: The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1-2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans
database_cross_reference: Pancreas
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0030274
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181277001
database_cross_reference: AAO:0010112
database_cross_reference: BTO:0000988
database_cross_reference: CALOHA:TS-0736
database_cross_reference: EFO:0000855
database_cross_reference: EHDAA2:0001367
database_cross_reference: EHDAA:6893
database_cross_reference: EMAPA:17503
database_cross_reference: EV:0100092
database_cross_reference: FMA:7198
database_cross_reference: GAID:334
database_cross_reference: MA:0000120
database_cross_reference: MAT:0000075
database_cross_reference: MESH:D010179
database_cross_reference: MIAA:0000075
database_cross_reference: NCIT:C12393
database_cross_reference: OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000140
database_cross_reference: UMLS:C0030274
database_cross_reference: VHOG:0000050
database_cross_reference: XAO:0000136
database_cross_reference: ZFA:0000140
database_cross_reference: galen:Pancreas
has_obo_namespace: uberon
id: UBERON:0001264
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

epididymis
type: Class
subclass of: tube
subclass of: mesoderm-derived structure
subclass of: duct of male reproductive system
definition: the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
editor note: Kardong has epididymis in elasmobranch
imported from: uberon.owl
has_relational_adjective: epididymal
taxon_notes: A similar, but probably non-homologous, structure is found in cartilaginous fishes
structure_notes: Typically divided into three main regions. In reptiles, there is an additional canal between the testis and the head of the epididymis, which receives the various efferent ducts. This is, however, absent in all birds and mammals. The epididymis is covered by a two layered pseudostratified epithelium. The epithelium is separated by a basement membrane from the connective tissue wall which has smooth muscle cells.
database_cross_reference: Epididymis
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014533
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181432000
database_cross_reference: BTO:0000408
database_cross_reference: CALOHA:TS-0285
database_cross_reference: EFO:0000982
database_cross_reference: EMAPA:19290
database_cross_reference: EV:0100103
database_cross_reference: FMA:18255
database_cross_reference: GAID:397
database_cross_reference: MA:0000397
database_cross_reference: MAT:0000130
database_cross_reference: MESH:A05.360.444.849.286
database_cross_reference: MIAA:0000130
database_cross_reference: NCIT:C12328
database_cross_reference: UMLS:C0014533
database_cross_reference: VHOG:0001265
database_cross_reference: galen:Epididymis
has_obo_namespace: uberon
has_related_synonym: Nebenhoden@de
id: UBERON:0001301
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim

external acoustic meatus
type: Class
subclass of: anatomical conduit
subclass of: endoderm-derived structure
subclass of: ectoderm-derived structure
definition: A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter.
editor note: consider revisiting superclass after refinement of CARO/EAO, conduit may not be quite correct.
imported from: uberon.owl
development_notes: tympanic ring, which serves as support for the tympanic membrane, directs invagination of the first pharingeal cleft ectoderm to form the external acoustic meatus (EAM), which provides the outer layer of the membrane[PMID 11237469]
external_ontology_notes: subdivision of head in FMA.
is part of: 外耳
database_cross_reference: External acoustic meatus
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013444
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181178004
database_cross_reference: EHDAA2:0000460
database_cross_reference: EHDAA:8975
database_cross_reference: EMAPA:17588
database_cross_reference: EV:0100356
database_cross_reference: FMA:61734
database_cross_reference: GAID:864
database_cross_reference: MA:0000260
database_cross_reference: MESH:D004424
database_cross_reference: NCIT:C12498
database_cross_reference: OpenCyc:Mx4rvli-nZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0013444
database_cross_reference: VHOG:0000977
database_cross_reference: galen:ExternalAuditoryMeatus
has_exact_synonym: auditory canal
has_exact_synonym: ear canal
has_exact_synonym: external acoustic tube
has_exact_synonym: external auditory canal
has_exact_synonym: external auditory tube
has_obo_namespace: uberon
has_related_synonym: auditory meatus
has_related_synonym: external auditory meatus
id: UBERON:0001352
in_subset: pheno slim
in_subset: uberon slim
label: 外耳道 @zh

chest
type: Class
subclass of: subdivision of trunk
definition: Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA].
editor note: FMA:24216 present in FMA1, but gone in subsequent versions
imported from: uberon.owl
has_relational_adjective: pectoral
has_relational_adjective: thoracic
database_cross_reference: Chest
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0817096
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1527391
database_cross_reference: BTO:0001368
database_cross_reference: CALOHA:TS-1039
database_cross_reference: EFO:0000965
database_cross_reference: EMAPA:37232
database_cross_reference: EV:0100010
database_cross_reference: FMA:9576
database_cross_reference: GAID:91
database_cross_reference: MA:0000031
database_cross_reference: MAT:0000295
database_cross_reference: MESH:A01.911
database_cross_reference: MIAA:0000295
database_cross_reference: NCIT:C12799
database_cross_reference: NCIT:C25389
database_cross_reference: OpenCyc:Mx4rvVikFZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0817096
database_cross_reference: UMLS:C1527391
database_cross_reference: galen:Chest
database_cross_reference: galen:Thorax
has_exact_synonym: anterolateral part of thorax
has_exact_synonym: front of thorax
has_exact_synonym: pectus
has_exact_synonym: ventral part of thoracic region
has_obo_namespace: uberon
has_related_synonym: thoracic body wall
has_related_synonym: thorax
id: UBERON:0001443
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim

subdivision of head
type: Class
subclass of: organism subdivision
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/123852005
database_cross_reference: FMA:24218
database_cross_reference: XAO:0000040
has_exact_synonym: head subdivision
has_obo_namespace: uberon
has_related_synonym: head region
has_related_synonym: region of head
id: UBERON:0001444
in_subset: non informative

skin of external ear
type: Class
subclass of: skin of head
subclass of: structure with developmental contribution from neural crest
definition: A zone of skin that is part of a external ear [Automatically generated definition].
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0222110
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/244073008
database_cross_reference: EMAPA:35301
database_cross_reference: FMA:24775
database_cross_reference: MA:0001233
database_cross_reference: NCIT:C49481
database_cross_reference: UMLS:C0222110
has_exact_synonym: auricular region of head zone of skin
has_exact_synonym: auricular region zone of skin
has_exact_synonym: ear skin
has_exact_synonym: external ear skin
has_exact_synonym: external ear zone of skin
has_exact_synonym: outer ear zone of skin
has_exact_synonym: zone of skin of auricular region
has_exact_synonym: zone of skin of auricular region of head
has_exact_synonym: zone of skin of external ear
has_exact_synonym: zone of skin of outer ear
has_obo_namespace: uberon
id: UBERON:0001459
in_subset: pheno slim
label: 外耳皮肤 @zh

bone element
type: Class
subclass of: skeletal element
definition: Skeletal element that is composed of bone tissue.
imported from: uberon.owl
external_definition: Also called osseous tissue, (Latin: os). Is a type of hard endoskeletal connective tissue found in many vertebrate animals. Bone is the main tissue of body organs that support body structures, protect internal organs, (in conjunction with muscles) facilitate movement; and are involved with cell formation, calcium metabolism, and mineral storage.[AAO]
external_definition: Portion of tissue which is calcified connective tissue making up the structural elements of the skeletal system.[TAO]
external_definition: Skeletal element that is composed of bone tissue.[VSAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: The 'new animal phylogeny' reveals that many of the groups known to biomineralize sit among close relatives that do not, and it favours an interpretation of convergent or parallel evolution for biomineralization in animals. (...) Whether this 'biomineralization toolkit'of genes reflects a parallel co-option of a common suite of genes or the inheritance of a skeletogenic gene regulatory network from a biomineralizing common ancestor remains an open debate.[debated][VHOG]
database_cross_reference: Bone
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0262950
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/90780006
database_cross_reference: AAO:0000047
database_cross_reference: AEO:0000082
database_cross_reference: BTO:0000140
database_cross_reference: CALOHA:TS-0088
database_cross_reference: EFO:0000298
database_cross_reference: EHDAA2:0003082
database_cross_reference: EMAPA:32782
database_cross_reference: ENVO:00002039
database_cross_reference: EV:0100140
database_cross_reference: FMA:30317
database_cross_reference: FMA:5018
database_cross_reference: GAID:92
database_cross_reference: MA:0001459
database_cross_reference: MAT:0000299
database_cross_reference: MIAA:0000299
database_cross_reference: NCIT:C12366
database_cross_reference: OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001514
database_cross_reference: UMLS:C0262950
database_cross_reference: VHOG:0001190
database_cross_reference: VSAO:0000057
database_cross_reference: XAO:0000169
database_cross_reference: ZFA:0001514
database_cross_reference: galen:Bone
has_exact_synonym: bone organ
has_obo_namespace: uberon
has_related_synonym: bone
has_related_synonym: bones
id: UBERON:0001474
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

lower respiratory tract
type: Class
subclass of: proximo-distal subdivision of respiratory tract
definition: The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]
imported from: uberon.owl
database_cross_reference: Lower respiratory tract
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/281488008
database_cross_reference: EHDAA2:0001036
database_cross_reference: EMAPA:16738
database_cross_reference: FMA:45662
database_cross_reference: MA:0000435
database_cross_reference: OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g
database_cross_reference: VHOG:0000382
has_exact_synonym: lower respiratory system
has_obo_namespace: uberon
id: UBERON:0001558
in_subset: pheno slim
in_subset: uberon slim

neck of organ
type: Class
subclass of: zone of organ
imported from: uberon.owl
database_cross_reference: FMA:45733
has_exact_synonym: organ neck
has_obo_namespace: uberon
id: UBERON:0001560
in_subset: non informative

coronary artery
type: Class
subclass of: heart blood vessel
subclass of: systemic artery
definition: An artery that supplies the myocardium.
imported from: uberon.owl
database_cross_reference: Coronary anatomy
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0205042
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181294004
database_cross_reference: BTO:0000290
database_cross_reference: CALOHA:TS-0176
database_cross_reference: EFO:0002551
database_cross_reference: EMAPA:19160
database_cross_reference: EV:0100383
database_cross_reference: FMA:49893
database_cross_reference: MA:0002453
database_cross_reference: NCIT:C12843
database_cross_reference: OpenCyc:Mx4rvoL56ZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0205042
database_cross_reference: VHOG:0001557
database_cross_reference: ZFA:0005812
database_cross_reference: galen:CoronaryArtery
has_exact_synonym: coronary arterial tree
has_obo_namespace: uberon
has_related_synonym: coronary vessel
id: UBERON:0001621
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim

artery
type: Class
subclass of: arterial blood vessel
definition: An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].
editor note: Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme.
imported from: uberon.owl
external_definition: Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO]
homology_notes: The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]
has_relational_adjective: arterial
fma_set_term: FMA_63812
database_cross_reference: Artery
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0003842
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362877004
database_cross_reference: AAO:0010211
database_cross_reference: AEO:0000208
database_cross_reference: BTO:0000573
database_cross_reference: CALOHA:TS-0054
database_cross_reference: EFO:0000814
database_cross_reference: EHDAA2:0000143
database_cross_reference: EHDAA2:0003253
database_cross_reference: EMAPA:35147
database_cross_reference: EV:0100026
database_cross_reference: FMA:50720
database_cross_reference: GAID:468
database_cross_reference: MA:0000064
database_cross_reference: MAT:0000034
database_cross_reference: MESH:D001158
database_cross_reference: MIAA:0000034
database_cross_reference: NCIT:C12372
database_cross_reference: OpenCyc:Mx4rvVjknZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000005
database_cross_reference: UMLS:C0003842
database_cross_reference: VHOG:0001251
database_cross_reference: XAO:0000114
database_cross_reference: ZFA:0000005
database_cross_reference: galen:Artery
has_exact_synonym: arterial subtree
has_exact_synonym: arterial tree organ part
has_exact_synonym: arteries
has_obo_namespace: uberon
has_related_synonym: arterial system
has_related_synonym: arterial vessel
id: UBERON:0001637
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

ear
type: Class
subclass of: sense organ
subclass of: structure with developmental contribution from neural crest
definition: Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
imported from: uberon.owl
external_definition: The organ of hearing and of equilibrium. [TFD][VHOG]
homology_notes: Both vertebrate and invertebrate auditory organs are thought to have evolved from primitive mechanosensors, but the nature of the ancestral structure and the evolutionary trajectories followed in distinct animal lineages remain unknown. In particular, we do not know how many types of mechanosensor existed in the protostome-deuterostome ancestor from which insects and vertebrates evolved or whether the PDA had an auditory organ.[well established][VHOG]
has_relational_adjective: auricular
database_cross_reference: Ear
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013443
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0521421
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/1910005
database_cross_reference: AAO:0011014
database_cross_reference: BIRNLEX:1062
database_cross_reference: BTO:0000368
database_cross_reference: CALOHA:TS-1165
database_cross_reference: EFO:0000826
database_cross_reference: EHDAA2:0000423
database_cross_reference: EHDAA:502
database_cross_reference: EMAPA:16193
database_cross_reference: EV:0100353
database_cross_reference: FMA:52780
database_cross_reference: GAID:62
database_cross_reference: MA:0000236
database_cross_reference: MAT:0000138
database_cross_reference: MESH:D004423
database_cross_reference: MIAA:0000138
database_cross_reference: NCIT:C12394
database_cross_reference: OpenCyc:Mx4rvViXS5wpEbGdrcN5Y29ycA
database_cross_reference: OpenCyc:Mx4rvVjL05wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0013443
database_cross_reference: UMLS:C0521421
database_cross_reference: VHOG:0000330
database_cross_reference: XAO:0000189
database_cross_reference: galen:Ear
has_obo_namespace: uberon
has_related_synonym: auditory apparatus
has_related_synonym: auris
id: UBERON:0001690
in_subset: efo slim
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
label: 耳 @zh

external ear
type: Class
subclass of: subdivision of head
subclass of: lateral structure
definition: Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO].
imported from: uberon.owl
external_definition: The external part of the organ, which consists of an outer portion (external auditory meatus) which leads to the tympanum. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
homology_notes: Some species, like Amolops tormotus (Feng et al. 2006), have a cavity in front of the tympanic membrane which is considered to be an ear canal and thus an outer ear. (...) The ancestral lineage of amphibians separated from the mammalian lineage, approximately 350 million years ago, in the paleozoic era. Many of the important developments in the auditory systems emerged after the ancestral paths separated (Manley and Clack 2003). This implies that shared features, like the tympanic middle ear, developed independently in different vertebrate lineages.[uncertain][VHOG]
external_ontology_notes: in XAO this includes and is only the tympanum
has_broad_synonym: auricular region
database_cross_reference: External ear
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0013453
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1269548
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/420893000
database_cross_reference: AAO:0011037
database_cross_reference: BIRNLEX:1705
database_cross_reference: BTO:0002100
database_cross_reference: EFO:0004221
database_cross_reference: EHDAA2:0000462
database_cross_reference: EHDAA:3786
database_cross_reference: EMAPA:16991
database_cross_reference: EV:0100354
database_cross_reference: FMA:52781
database_cross_reference: GAID:104
database_cross_reference: MA:0000258
database_cross_reference: MAT:0000147
database_cross_reference: MESH:D004431
database_cross_reference: MIAA:0000147
database_cross_reference: NCIT:C12292
database_cross_reference: OpenCyc:Mx4rwOHtXJwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0013453
database_cross_reference: UMLS:C1269548
database_cross_reference: VHOG:0000311
database_cross_reference: XAO:0000190
has_exact_synonym: auricular region of head
has_exact_synonym: outer ear
has_obo_namespace: uberon
has_related_synonym: auris externa
id: UBERON:0001691
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
label: 外耳 @zh

pinna
type: Class
subclass of: subdivision of head
subclass of: structure with developmental contribution from neural crest
definition: The part of the ear that projects from the head, connecting to the external acoustic meatus.
imported from: uberon.owl
external_definition: The external expanded part of the ear characterized by a funnel-shaped structure through which the sound vibrations are received. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
homology_notes: Mammals have a third type of tympanic ear. An external flap, the auricle or pinna, helps funnel sound waves down the external acoustic meatus to the tympanic membrane.[well established][VHOG]
taxon_notes: In various species, the pinna can also signal mood and radiate heat
function_notes: The purpose of the pinna is to collect sound. It does so by acting as a funnel, amplifying the sound and directing it to the ear canal. While reflecting from the pinna, sound also goes through a filtering process which adds directional information to the sound (see sound localization, head-related transfer function, pinna notch).
database_cross_reference: Pinna (anatomy)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0928075
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/421159007
database_cross_reference: EHDAA2:0001467
database_cross_reference: EMAPA:17589
database_cross_reference: EV:0100355
database_cross_reference: FMA:56580
database_cross_reference: MA:0000259
database_cross_reference: NCIT:C32165
database_cross_reference: OpenCyc:Mx4rvs_VC5wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0928075
database_cross_reference: VHOG:0000460
database_cross_reference: galen:Auricle
has_exact_synonym: auricle
has_exact_synonym: auricle of ear
has_exact_synonym: auricle of external ear
has_exact_synonym: auricula
has_exact_synonym: auricula (auris externa)
has_exact_synonym: pinna of ear
has_exact_synonym: 耳郭 @zh
has_obo_namespace: uberon
has_related_synonym: pinnae
id: UBERON:0001757
in_subset: pheno slim
in_subset: uberon slim
label: 耳廓 @zh

lobule of pinna
type: Class
subclass of: structure with developmental contribution from neural crest
subclass of: external soft tissue zone
definition: The soft lower part of the external ear, projecting below the antitragus.
imported from: uberon.owl
structure_notes: The earlobe is composed of tough areolar and adipose (fatty) connective tissues, lacking the firmness and elasticity of the rest of the pinna. Since the earlobe does not contain cartilage the earlobe has a large blood supply and may help to warm the ears and maintain balance but generally earlobes are not considered to have any major biological function.
database_cross_reference: Ear lobe
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0229315
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362544006
database_cross_reference: FMA:60984
database_cross_reference: MA:0002468
database_cross_reference: NCIT:C32999
database_cross_reference: UMLS:C0229315
has_exact_synonym: auricular lobule
has_exact_synonym: ear lobe
has_exact_synonym: earlobe
has_exact_synonym: lobe of ear
has_exact_synonym: lobule of auricle of ear
has_exact_synonym: lobulus auriculae
has_exact_synonym: pinna lobule
has_obo_namespace: uberon
has_related_synonym: ear lobule
has_related_synonym: lobule of auricle
id: UBERON:0001847
in_subset: pheno slim
in_subset: uberon slim
label: 耳垂 @zh

blood vessel
type: Class
subclass of: vessel
subclass of: mesoderm-derived structure
definition: A vessel through which blood circulates in the body.
editor note: consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus
imported from: uberon.owl
external_definition: Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG]
external_definition: Any of the vessels through which blood circulates in the body.[AAO]
homology_notes: The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]
taxon_notes: annelids have blood vessels, but this class is not applicable to annelids.
external_ontology_notes: FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX
has_broad_synonym: vascular element
database_cross_reference: Blood vessel
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0005847
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361097006
database_cross_reference: AAO:0011004
database_cross_reference: AEO:0000207
database_cross_reference: BTO:0001102
database_cross_reference: CALOHA:TS-0080
database_cross_reference: EFO:0000817
database_cross_reference: EHDAA2:0003252
database_cross_reference: EHDAA:240
database_cross_reference: EMAPA:32743
database_cross_reference: EMAPA:35993
database_cross_reference: FMA:50722
database_cross_reference: FMA:63183
database_cross_reference: GAID:169
database_cross_reference: MA:0000060
database_cross_reference: MAT:0000393
database_cross_reference: MESH:D001808
database_cross_reference: NCIT:C12679
database_cross_reference: NLXANAT:090901
database_cross_reference: OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0002137
database_cross_reference: UMLS:C0005847
database_cross_reference: VHOG:0001250
database_cross_reference: XAO:0001011
database_cross_reference: ZFA:0005314
has_exact_synonym: region of vascular tree organ
has_exact_synonym: vascular tree organ region
has_obo_namespace: uberon
has_related_synonym: vas sanguineum
id: UBERON:0001981
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

thyroid gland
type: Class
subclass of: endocrine gland
subclass of: endoderm-derived structure
subclass of: structure with developmental contribution from neural crest
definition: A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].
imported from: uberon.owl
external_definition: Either of paired structures located in the throat which develop from the ventral wall of the pharynx and excretes hormones involved in the morphological and functional changes during metamorphosis as well as influencing other tissues.[AAO]
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (2) a groove in the pharyngeal floor known as the endostyle, or a thyroid gland derived from part of the endostyle (...).[well established][VHOG]
taxon_notes: In fish, it is usually located below the gills and is not always divided into distinct lobes. However, in some teleosts, patches of thyroid tissue are found elsewhere in the body, associated with the kidneys, spleen, heart, or eyes
taxon_notes: In larval lampreys, the thyroid originates as an exocrine gland, secreting its hormones into the gut, and associated with the larva's filter-feeding apparatus. In the adult lamprey, the gland separates from the gut, and becomes endocrine, but this path of development may reflect the evolutionary origin of the thyroid. For instance, the closest living relatives of vertebrates, the tunicates and Amphioxus, have a structure very similar to that of larval lampreys, and this also secretes iodine-containing compounds (albeit not thyroxine)
taxon_notes: In tetrapods, the thyroid is always found somewhere in the neck region. In most tetrapod species, there are two paired thyroid glands - that is, the right and left lobes are not joined together. However, there is only ever a single thyroid gland in most mammals, and the shape found in humans is common to many other species
database_cross_reference: Thyroid
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0040132
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181117000
database_cross_reference: AAO:0010544
database_cross_reference: BTO:0001379
database_cross_reference: CALOHA:TS-1047
database_cross_reference: EFO:0000861
database_cross_reference: EHDAA2:0002028
database_cross_reference: EHDAA:2148
database_cross_reference: EHDAA:2975
database_cross_reference: EMAPA:17068
database_cross_reference: EV:0100133
database_cross_reference: FMA:9603
database_cross_reference: GAID:465
database_cross_reference: MA:0000129
database_cross_reference: MAT:0000081
database_cross_reference: MESH:D013961
database_cross_reference: MIAA:0000081
database_cross_reference: NCIT:C12400
database_cross_reference: OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0040132
database_cross_reference: VHOG:0000418
database_cross_reference: XAO:0000162
database_cross_reference: galen:ThyroidGland
has_exact_synonym: thyroid
has_obo_namespace: uberon
has_related_synonym: glandula thyroidea
id: UBERON:0002046
in_subset: efo slim
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim

lung
type: Class
subclass of: respiration organ
subclass of: endoderm-derived structure
subclass of: thoracic cavity element
subclass of: lateral structure
definition: Respiration organ that develops as an outpocketing of the esophagus.
imported from: uberon.owl
external_definition: Either of two organs which allow gas exchange absorbing oxygen from inhaled air and releasing carbon dioxide with exhaled air.[AAO]
homology_notes: Lungs had already developed as paired ventral pockets from the intestine in the ancestor of Osteognathostomata. (...) In actinopterygian fishes, apart from Cladistia, the ventral intestinal pocket migrates dorsally and becomes the swim-bladder, a mainly hydrostatical organ (reference 1); Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung (reference 2).[well established][VHOG]
has_relational_adjective: pulmonary
taxon_notes: respiration organ in all air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located in the chest on either side of the heart. Their principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in the mosaic of specialized cells that form millions of tiny, exceptionally thin-walled air sacs called alveoli. // Avian lungs do not have alveoli as mammalian lungs do, they have Faveolar lungs. They contain millions of tiny passages known as para-bronchi, connected at both ends by the dorsobronchi
database_cross_reference: Lung
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0024109
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181216001
database_cross_reference: AAO:0000275
database_cross_reference: AAO:0010567
database_cross_reference: BTO:0000763
database_cross_reference: CALOHA:TS-0568
database_cross_reference: EFO:0000934
database_cross_reference: EHDAA2:0001042
database_cross_reference: EHDAA:1554
database_cross_reference: EHDAA:2205
database_cross_reference: EMAPA:16728
database_cross_reference: EV:0100042
database_cross_reference: FMA:7195
database_cross_reference: GAID:345
database_cross_reference: MA:0000415
database_cross_reference: MAT:0000135
database_cross_reference: MESH:D008168
database_cross_reference: MIAA:0000135
database_cross_reference: NCIT:C12468
database_cross_reference: OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0024109
database_cross_reference: VHOG:0000310
database_cross_reference: XAO:0000119
database_cross_reference: galen:Lung
has_exact_synonym: pulmo
has_obo_namespace: uberon
id: UBERON:0002048
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
comment: Snakes and limbless lizards typically possess only the right lung as a major respiratory organ; the left lung is greatly reduced, or even absent. Amphisbaenians, however, have the opposite arrangement, with a major left lung, and a reduced or absent right lung [WP]

viscus
type: Class
subclass of: trunk region element
definition: An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.
imported from: uberon.owl
external_definition: An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO]
external_ontology_notes: general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs.
database_cross_reference: Viscus
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0042779
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/118760003
database_cross_reference: AAO:0010386
database_cross_reference: BTO:0001491
database_cross_reference: EHDAA:512
database_cross_reference: EMAPA:16245
database_cross_reference: FMA:7085
database_cross_reference: MA:0000019
database_cross_reference: MESH:D014781
database_cross_reference: NCIT:C28287
database_cross_reference: RETIRED_EHDAA2:0002201
database_cross_reference: UMLS:C0042779
database_cross_reference: XAO:0003034
has_exact_synonym: visceral organ
has_exact_synonym: visceral organ system
has_obo_namespace: uberon
has_related_synonym: Organsystem@de
has_related_synonym: splanchnic tissue
has_related_synonym: viscera
has_related_synonym: visceral tissue
id: UBERON:0002075
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: upper level

cardiac atrium
type: Class
subclass of: cardiac chamber
definition: Cardiac chamber in which blood enters the heart.
imported from: uberon.owl
external_definition: One of four heart chambers.[TAO]
external_definition: One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO]
homology_notes: In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG]
database_cross_reference: Heart atrium
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018792
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/261405004
database_cross_reference: AAO:0010246
database_cross_reference: BTO:0000903
database_cross_reference: CALOHA:TS-0437
database_cross_reference: EFO:0000277
database_cross_reference: EHDAA2:0000154
database_cross_reference: EHDAA:1265
database_cross_reference: EMAPA:16688
database_cross_reference: EV:0100019
database_cross_reference: FMA:7099
database_cross_reference: GAID:555
database_cross_reference: MA:0000073
database_cross_reference: MAT:0000496
database_cross_reference: MESH:D006325
database_cross_reference: NCIT:C12728
database_cross_reference: TAO:0000471
database_cross_reference: UMLS:C0018792
database_cross_reference: VHOG:0000175
database_cross_reference: ZFA:0000471
database_cross_reference: galen:Atrium
has_exact_synonym: atria
has_exact_synonym: atrium
has_exact_synonym: atrium of heart
has_exact_synonym: cardiac atria
has_exact_synonym: heart atrium
has_obo_namespace: uberon
has_related_synonym: atrial tissue
id: UBERON:0002081
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

cardiac ventricle
type: Class
subclass of: cardiac chamber
definition: Cardiac chamber through which blood leaves the heart.
imported from: uberon.owl
external_definition: A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO]
external_definition: One of four heart chambers.[TAO]
homology_notes: In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG]
has_broad_synonym: ventricle
database_cross_reference: Ventricle (heart)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0018827
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/277699000
database_cross_reference: AAO:0010249
database_cross_reference: BTO:0000862
database_cross_reference: CALOHA:TS-0444
database_cross_reference: EFO:0000317
database_cross_reference: EHDAA2:0004164
database_cross_reference: EHDAA:1912
database_cross_reference: EMAPA:17331
database_cross_reference: EV:0100020
database_cross_reference: FMA:7100
database_cross_reference: GAID:568
database_cross_reference: MA:0000091
database_cross_reference: MAT:0000497
database_cross_reference: MESH:D006352
database_cross_reference: NCIT:C12730
database_cross_reference: OpenCyc:Mx4rvVjj1pwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000009
database_cross_reference: UMLS:C0018827
database_cross_reference: VHOG:0000435
database_cross_reference: XAO:0003193
database_cross_reference: ZFA:0000009
database_cross_reference: galen:Ventricle
has_exact_synonym: heart ventricle
has_exact_synonym: lower chamber of heart
has_exact_synonym: ventricle of heart
has_obo_namespace: uberon
id: UBERON:0002082
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

heart left ventricle
type: Class
subclass of: cardiac ventricle
subclass of: left cardiac chamber
definition: A cardiac ventricle that is in the left side of the heart.
imported from: uberon.owl
external_definition: Thick-walled muscular chamber constituting the left border and apex of the heart. It receives oxygenated blood from the left atrium through the mitral orifice and send it off into the aorta. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]
homology_notes: The vertebrate heart initially forms as a tube from a population of precursor cells termed the first heart field (FHF). Cells from the adjacent second heart field (SHF) are then progressively added to the developing heart. In avian and mammalian hearts, the FHF contributes mainly to the left ventricle, whereas the SHF gives rise to the outflow tract and large portions of the right ventricle and atria. Both fields arise from common mesodermal progenitors, although the detailed lineage relationships between FHF and SHF remain uncertain.[well established][VHOG]
implements_design_pattern: https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern
taxon_notes: In mammals continuous with aorta
database_cross_reference: Left ventricle
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0225897
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/244385005
database_cross_reference: BTO:0001629
database_cross_reference: CALOHA:TS-0439
database_cross_reference: EHDAA2:0002178
database_cross_reference: EMAPA:17337
database_cross_reference: FMA:7101
database_cross_reference: MA:0000092
database_cross_reference: NCIT:C12871
database_cross_reference: OpenCyc:Mx4rtW8v46gEEdudWQACs5b6Bw
database_cross_reference: UMLS:C0225897
database_cross_reference: VHOG:0000718
database_cross_reference: galen:LeftVentricle
has_exact_synonym: cardiac left ventricle
has_exact_synonym: left cardiac ventricle
has_exact_synonym: left ventricle
has_exact_synonym: left ventricle of heart
has_obo_namespace: uberon
has_related_synonym: ventriculus sinister cordis
id: UBERON:0002084
in_subset: pheno slim
in_subset: uberon slim

liver
type: Class
subclass of: exocrine gland
subclass of: endoderm-derived structure
subclass of: abdomen element
subclass of: digestive system gland
definition: An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
imported from: uberon.owl
external_definition: Organ which secretes bile and participates in formation of certain blood proteins.[AAO]
axiom_lost_from_external_ontology: relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]
homology_notes: All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]
has_relational_adjective: hepatic
taxon_notes: An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).
taxon_notes: The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.
function_notes: secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
external_ontology_notes: Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function.
database_cross_reference: Liver
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0023884
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181268008
database_cross_reference: AAO:0010111
database_cross_reference: BTO:0000759
database_cross_reference: CALOHA:TS-0564
database_cross_reference: EFO:0000887
database_cross_reference: EHDAA2:0000997
database_cross_reference: EHDAA:2197
database_cross_reference: EMAPA:16846
database_cross_reference: EV:0100089
database_cross_reference: FMA:7197
database_cross_reference: GAID:288
database_cross_reference: MA:0000358
database_cross_reference: MAT:0000097
database_cross_reference: MESH:D008099
database_cross_reference: MIAA:0000097
database_cross_reference: NCIT:C12392
database_cross_reference: OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0000123
database_cross_reference: UMLS:C0023884
database_cross_reference: VHOG:0000257
database_cross_reference: XAO:0000133
database_cross_reference: ZFA:0000123
database_cross_reference: galen:Liver
has_obo_namespace: uberon
has_related_synonym: iecur
has_related_synonym: jecur
id: UBERON:0002107
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core
depicted by: Leber:Schaf.jpg

small intestine
type: Class
subclass of: subdivision of digestive tract
subclass of: digestive system element
definition: Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].
imported from: uberon.owl
external_definition: The terminal region of the mid intestine is comprised of specialized enterocytes that appear to play a role in mucosal immunity. Wallace et al, 2005.[TAO]
homology_notes: Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]
database_cross_reference: Small intestine
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0021852
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181250005
database_cross_reference: AAO:0010397
database_cross_reference: BTO:0000651
database_cross_reference: CALOHA:TS-0942
database_cross_reference: EFO:0000841
database_cross_reference: EMAPA:32834
database_cross_reference: EV:0100072
database_cross_reference: FMA:7200
database_cross_reference: GAID:313
database_cross_reference: MA:0000337
database_cross_reference: MAT:0000047
database_cross_reference: MESH:A03.492.411.620
database_cross_reference: MIAA:0000047
database_cross_reference: NCIT:C12386
database_cross_reference: OpenCyc:Mx4rvVjlIJwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001323
database_cross_reference: UMLS:C0021852
database_cross_reference: VHOG:0000055
database_cross_reference: XAO:0000130
database_cross_reference: ZFA:0001323
database_cross_reference: galen:SmallIntestine
has_exact_synonym: small bowel
has_exact_synonym: small intestine
has_obo_namespace: uberon
has_related_synonym: anterior intestine
has_related_synonym: intestinum tenue
has_related_synonym: mid intestine
id: UBERON:0002108
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

kidney
type: Class
subclass of: cavitated compound organ
subclass of: abdomen element
subclass of: lateral structure
definition: A paired organ of the urinary tract which has the production of urine as its primary function.
imported from: uberon.owl
external_definition: One of either of a pair of structures lying on either side of the dorsal aorta in which fluid balance is regulated and waste is excreted out in the form of urine.[AAO]
has_relational_adjective: renal
fma_set_term: FMA_264815
database_cross_reference: Kidney
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0022646
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181414000
database_cross_reference: AAO:0000250
database_cross_reference: BTO:0000671
database_cross_reference: CALOHA:TS-0510
database_cross_reference: EFO:0000929
database_cross_reference: EMAPA:17373
database_cross_reference: EV:0100096
database_cross_reference: FMA:7203
database_cross_reference: GAID:423
database_cross_reference: MA:0000368
database_cross_reference: MAT:0000119
database_cross_reference: MESH:D007668
database_cross_reference: MIAA:0000119
database_cross_reference: NCIT:C12415
database_cross_reference: OpenCyc:Mx4rvVjlYpwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0022646
database_cross_reference: XAO:0003267
database_cross_reference: galen:Kidney
has_narrow_synonym: reniculate kidney
has_obo_namespace: uberon
id: UBERON:0002113
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

musculoskeletal system
type: Class
subclass of: anatomical system
definition: Anatomical system that consists of the muscular and skeletal systems.
imported from: uberon.owl
external_definition: Anatomical system that provides locomotion and physical support to the organism.[AAO]
homology_notes: There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG]
has_relational_adjective: musculoskeletal
contributor: cmungall
database_cross_reference: Musculoskeletal system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0026860
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/278858007
database_cross_reference: AAO:0010546
database_cross_reference: CALOHA:TS-1311
database_cross_reference: EMAPA:32714
database_cross_reference: EV:0100139
database_cross_reference: FMA:7482
database_cross_reference: GAID:98
database_cross_reference: MA:0002418
database_cross_reference: MESH:D009141
database_cross_reference: NCIT:C12754
database_cross_reference: OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g
database_cross_reference: UMLS:C0026860
database_cross_reference: VHOG:0001275
database_cross_reference: VSAO:0000031
database_cross_reference: XAO:0000168
has_exact_synonym: musculo-skeletal system
has_obo_namespace: uberon
id: UBERON:0002204
in_subset: uberon slim

synovial joint
type: Class
subclass of: skeletal joint
definition: Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]
imported from: uberon.owl
external_definition: Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO]
database_cross_reference: Synovial joint
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/113234001
database_cross_reference: AEO:0000183
database_cross_reference: CALOHA:TS-2138
database_cross_reference: EHDAA2:0003183
database_cross_reference: FMA:7501
database_cross_reference: MA:0000322
database_cross_reference: NCIT:C32461
database_cross_reference: OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0005153
database_cross_reference: ZFA:0005153
database_cross_reference: galen:SynovialJoint
has_exact_synonym: articulatio synoviale
has_exact_synonym: diarthroses
has_exact_synonym: diarthrosis
has_exact_synonym: diarthrosis joint
has_obo_namespace: uberon
has_related_synonym: diarthrodial joints
id: UBERON:0002217
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

olfactory organ
type: Class
subclass of: sense organ
definition: An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ.
editor note: An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint
imported from: uberon.owl
external_ontology_notes: fma general anatomical term. xao has no subtypes (but Johnstons organ develops from this). An olfactory organ overlaps with the olfactory system, because some parts of the nose (e.g. nasal skeleton) are parts of the skeletal system, which is spatially disjoint
database_cross_reference: AAO:0010180
database_cross_reference: BTO:0001772
database_cross_reference: FBbt:00005158
database_cross_reference: FMA:77659
database_cross_reference: VHOG:0000287
database_cross_reference: XAO:0000273
has_exact_synonym: olfactory organ
has_exact_synonym: olfactory sense organ
has_exact_synonym: olfactory sensory organ
has_narrow_synonym: main olfactory organ
has_narrow_synonym: primary olfactory organ
has_obo_namespace: uberon
has_related_synonym: olfactory neuroepithelium
has_related_synonym: organ olfactus
has_related_synonym: organum olfactorium
id: UBERON:0002268
in_subset: functional classification

cerumen
type: Class
subclass of: sweat
definition: The yellow or brown waxy secretions produced by vestigial apocrine sweat glands in the external ear canal[MESH].
imported from: uberon.owl
has_relational_adjective: cerumenal
has_relational_adjective: cerumenous
function_notes: Cerumen keeps the eardrum pliable, lubricates and cleans the external auditory canal, waterproofs the canal, kills bacteria, and serves as a barrier to trap foreign particles (dust, fungal spores, etc.) by coating the guard hairs of the ear, making them sticky.
database_cross_reference: Earwax
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0740486
database_cross_reference: ENVO:02000028
database_cross_reference: FMA:79869
database_cross_reference: GAID:1158
database_cross_reference: MA:0002506
database_cross_reference: MESH:D002571
database_cross_reference: NCIT:C32293
database_cross_reference: UMLS:C0740486
has_exact_synonym: ear wax
has_exact_synonym: earwax
has_obo_namespace: uberon
id: UBERON:0002297
in_subset: uberon slim
label: 耵聍 @zh

exocrine gland
type: Class
subclass of: gland
definition: A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas
editor note: Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses
imported from: uberon.owl
database_cross_reference: Exocrine gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0015282
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/115976003
database_cross_reference: AEO:0000097
database_cross_reference: BTO:0000765
database_cross_reference: CALOHA:TS-2012
database_cross_reference: EHDAA2:0003097
database_cross_reference: EMAPA:35327
database_cross_reference: FMA:9596
database_cross_reference: GAID:34
database_cross_reference: MA:0002564
database_cross_reference: MESH:D005088
database_cross_reference: NCIT:C12712
database_cross_reference: UMLS:C0015282
has_exact_synonym: ducted gland
has_exact_synonym: glandula exocrina
has_obo_namespace: uberon
id: UBERON:0002365
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim

prostate gland
type: Class
subclass of: mixed endoderm/mesoderm-derived structure
subclass of: male accessory sex gland
definition: The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
editor note: TODO - FMA treats the gland as part of the prostate - see also FMA:74119.
imported from: uberon.owl
has_relational_adjective: prostatic
database_cross_reference: Prostate
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0033572
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181422007
database_cross_reference: BTO:0001129
database_cross_reference: CALOHA:TS-0828
database_cross_reference: EFO:0000858
database_cross_reference: EMAPA:19287
database_cross_reference: EV:0100104
database_cross_reference: FMA:9600
database_cross_reference: GAID:392
database_cross_reference: MA:0000404
database_cross_reference: MAT:0000078
database_cross_reference: MESH:D011467
database_cross_reference: MIAA:0000078
database_cross_reference: NCIT:C12410
database_cross_reference: OpenCyc:Mx4rv6trqZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0033572
database_cross_reference: VHOG:0001261
database_cross_reference: galen:ProstateGland
has_exact_synonym: male prostate
has_exact_synonym: prostate
has_obo_namespace: uberon
has_related_synonym: prostata
id: UBERON:0002367
in_subset: efo slim
in_subset: major organ
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim

endocrine gland
type: Class
subclass of: gland
definition: Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].
imported from: uberon.owl
database_cross_reference: Endocrine gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0014133
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/40818001
database_cross_reference: AEO:0000098
database_cross_reference: BTO:0001488
database_cross_reference: CALOHA:TS-1300
database_cross_reference: EHDAA2:0003098
database_cross_reference: EMAPA:35999
database_cross_reference: FMA:9602
database_cross_reference: GAID:335
database_cross_reference: MA:0002563
database_cross_reference: MESH:D004702
database_cross_reference: NCIT:C12704
database_cross_reference: OpenCyc:Mx4rvbkiRZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0014133
has_exact_synonym: ductless gland
has_exact_synonym: glandula endocrina
has_obo_namespace: uberon
has_related_synonym: ductless gland
has_related_synonym: glandulae endocrinae
id: UBERON:0002368
in_subset: organ slim
in_subset: pheno slim
in_subset: uberon slim

connective tissue
type: Class
subclass of: tissue
definition: Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.
imported from: uberon.owl
external_definition: One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO]
external_definition: Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO]
external_definition: Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO]
external_ontology_notes: MA also has set of connective tissues
contributor: cmungall
contributor: wdahdul
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0009780
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361919005
database_cross_reference: AAO:0000098
database_cross_reference: BTO:0000421
database_cross_reference: CALOHA:TS-2009
database_cross_reference: EFO:0000952
database_cross_reference: EMAPA:35251
database_cross_reference: FMA:9640
database_cross_reference: GAID:100
database_cross_reference: MA:0000011
database_cross_reference: MAT:0000301
database_cross_reference: MESH:D003238
database_cross_reference: MIAA:0000301
database_cross_reference: NCIT:C12374
database_cross_reference: OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001641
database_cross_reference: UMLS:C0009780
database_cross_reference: VSAO:0000017
database_cross_reference: XAO:0001017
database_cross_reference: ZFA:0001632
database_cross_reference: galen:ConnectiveTissue
has_exact_synonym: portion of connective tissue
has_exact_synonym: textus connectivus
has_obo_namespace: uberon
has_related_synonym: Bindegewebe
id: UBERON:0002384
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

muscle tissue
type: Class
subclass of: tissue
subclass of: mesoderm-derived structure
definition: Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
imported from: uberon.owl
external_definition: One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO]
database_cross_reference: Muscle tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C2328219
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91727004
database_cross_reference: AAO:0000306
database_cross_reference: AEO:0000122
database_cross_reference: CALOHA:TS-0642
database_cross_reference: EHDAA2:0003122
database_cross_reference: EMAPA:32715
database_cross_reference: FMA:9641
database_cross_reference: MA:0002437
database_cross_reference: MESH:D009132
database_cross_reference: NCIT:C12435
database_cross_reference: UMLS:C2328219
database_cross_reference: galen:MuscleTissue
has_exact_synonym: muscular tissue
has_exact_synonym: portion of muscle tissue
has_exact_synonym: textus muscularis
has_obo_namespace: uberon
id: UBERON:0002385
in_subset: uberon slim
comment: Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach.

immune system
type: Class
subclass of: anatomical system
definition: Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.
imported from: uberon.owl
homology_notes: The antibody-based immune system defined by the presence of the major histocompatibility complex (MHC), T cell receptor (TCR), B cell receptor (BCR) or recombination activating genes (RAGs) is known beginning from jawed fishes.[well established][VHOG]
database_cross_reference: Immune system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0020962
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362590003
database_cross_reference: AAO:0011003
database_cross_reference: BILA:0000104
database_cross_reference: BTO:0005810
database_cross_reference: FMA:9825
database_cross_reference: GAID:328
database_cross_reference: MA:0002711
database_cross_reference: MESH:D007107
database_cross_reference: NCIT:C12735
database_cross_reference: OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001159
database_cross_reference: UMLS:C0020962
database_cross_reference: VHOG:0001247
database_cross_reference: XAO:0003152
database_cross_reference: ZFA:0001159
has_obo_namespace: uberon
id: UBERON:0002405
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core

cartilage tissue
type: Class
subclass of: skeletal tissue
definition: Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.
imported from: uberon.owl
external_definition: A type of dense connective tissue. It is composed of cells called chondrocytes which are dispersed in a firm gel-like ground substance, called the matrix. Cartilage is avascular (contains no blood vessels) and nutrients are diffused through the matrix. Cartilage is found in the joints, the rib cage, the ear, the nose, in the throat and between intervertebral disks. It makes up virtually the entire skeleton in chondrichthyes.[AAO]
external_definition: Portion of tissue which is connective tissue composed of collagen and/or elastin fibers and chondrocytes. Cartilage is avascular and provides both skeletal functions and a framework upon which bone is deposited.[TAO]
external_definition: Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.[VSAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: Phylogenetic analysis suggests that cartilage arose independently in cnidarians, hemichordates, vertebrates, arthropods, annelids, brachiopods, and molluscs - or a common ancestor of brachiopods and molluscs (...). Analyses of cartilage as a tissue and of the development of invertebrate cartilages are consistent with homology between invertebrate and vertebrate cartilage. From the discussion above, it will be clear that understanding genetic changes underlying cartilage evolution is key to determining whether the multiple origins of cartilage represent parallel evolution.[well established][VHOG]
contributor: cmungall
contributor: mellybelly
database_cross_reference: Cartilage
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0007301
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/309312004
database_cross_reference: AAO:0000060
database_cross_reference: AEO:0000087
database_cross_reference: BTO:0000206
database_cross_reference: EFO:0000949
database_cross_reference: EHDAA2:0003087
database_cross_reference: EMAPA:32730
database_cross_reference: EV:0100141
database_cross_reference: FMA:37377
database_cross_reference: GAID:99
database_cross_reference: MA:0000104
database_cross_reference: MAT:0000189
database_cross_reference: MESH:D002356
database_cross_reference: MIAA:0000189
database_cross_reference: NCIT:C12373
database_cross_reference: NCIT:C32268
database_cross_reference: OpenCyc:Mx4rvVjeOZwpEbGdrcN5Y29ycA
database_cross_reference: TAO:0001501
database_cross_reference: UMLS:C0007301
database_cross_reference: VHOG:0001207
database_cross_reference: VSAO:0000040
database_cross_reference: XAO:0000170
database_cross_reference: ZFA:0005622
database_cross_reference: galen:Cartilage
has_exact_synonym: cartilage tissue
has_exact_synonym: cartilaginous tissue
has_exact_synonym: chondrogenic tissue
has_obo_namespace: uberon
has_related_synonym: cartilage
has_related_synonym: cartilages
has_related_synonym: portion of cartilage tissue
id: UBERON:0002418
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim
in_subset: vertebrate core
comment: Previous: "A portion of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate[GO]. Regular connective tissue, which consists of chondrocytes and related cells, the intercellular matrix of which is chondrified. Examples: hyaline cartilage, fibrocartilage, elastic cartilage[FMA]. an avascular supporting and articular skeletal tissue. It also functions as the primary endoskeletal support in vertebrate embryos. Cartilage is deposited by and is composed of chondroblasts and chondrocytes separated by an extracellular matrix, which may or may not mineralize depending on cartilage type, age, or taxon[Hall and Witten]." See also FMA:71500 Set of cartilages, FMA:55107 Cartilage organ, FMA:12264 Articular cartilage. // elements made from cartilage, cartilage-like, or chondroid tissues evolved in invertebrates[H&W]
label: 软骨组织 @zh

bone tissue
type: Class
subclass of: skeletal tissue
definition: Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.
editor note: see https://github.com/obophenotype/uberon/issues/27
imported from: uberon.owl
external_definition: Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.[VSAO]
database_cross_reference: Bone tissue
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0391978
database_cross_reference: CALOHA:TS-2011
database_cross_reference: EMAPA:35179
database_cross_reference: FMA:224804
database_cross_reference: MA:0002780
database_cross_reference: MESH:D001842
database_cross_reference: NCIT:C13076
database_cross_reference: UMLS:C0391978
database_cross_reference: VSAO:0000047
database_cross_reference: XAO:0004040
database_cross_reference: ZFA:0005621
database_cross_reference: galen:BoneTissue
has_exact_synonym: calcium tissue
has_exact_synonym: osseous tissue
has_exact_synonym: osteogenic tissue
has_narrow_synonym: mineralized bone tissue
has_obo_namespace: uberon
has_related_synonym: bone
has_related_synonym: portion of bone tissue
id: UBERON:0002481
in_subset: pheno slim
in_subset: uberon slim

helix of outer ear
type: Class
subclass of: subdivision of head
subclass of: structure with developmental contribution from neural crest
definition: The helix is the prominent rim of the pinna.
imported from: uberon.owl
database_cross_reference: Helix (ear)
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0229304
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/279607004
database_cross_reference: FMA:60992
database_cross_reference: MA:0002793
database_cross_reference: NCIT:C32724
database_cross_reference: OpenCyc:Mx4rwRDEk5wpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0229304
has_exact_synonym: helical part of pinna
has_exact_synonym: helix
has_exact_synonym: helix (auricula)
has_exact_synonym: helix of auricle of ear
has_exact_synonym: helix of ear
has_exact_synonym: helix of external ear
has_exact_synonym: helix of pinna
has_obo_namespace: uberon
id: UBERON:0002488
in_subset: pheno slim
in_subset: uberon slim
label: 耳轮 @zh

limb segment
type: Class
subclass of: paired limb/fin segment
definition: A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles.
editor note: TODO - align this with the CARO2 class 'appendage segment'; note the FMA class does not appear to require repetition
imported from: uberon.owl
external_ontology_notes: FMA has both limb segment and free limb segment, the former includes the girdles. Note that MA uses the term more generally and includes A,S,Z,S+Z(arm/leg), whereas FMA is just A,S,Z
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1268195
database_cross_reference: FMA:241863
database_cross_reference: MA:0002889
database_cross_reference: NCIT:C38630
database_cross_reference: UMLS:C1268195
has_exact_synonym: free limb segment
has_exact_synonym: segment of limb
has_exact_synonym: subdivision of limb
has_obo_namespace: uberon
has_related_synonym: extremity part
has_related_synonym: limb region
has_related_synonym: region of limb
id: UBERON:0002529

gland
type: Class
subclass of: organ
definition: an organ that functions as a secretory or excretory organ
imported from: uberon.owl
has_relational_adjective: glandular
has_alternative_id: UBERON:MIAA_0000021
database_cross_reference: Gland
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1285092
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/134358001
database_cross_reference: AAO:0000212
database_cross_reference: AEO:0000096
database_cross_reference: BTO:0000522
database_cross_reference: EFO:0000797
database_cross_reference: EHDAA2:0003096
database_cross_reference: EHDAA:2161
database_cross_reference: EHDAA:4475
database_cross_reference: EHDAA:6522
database_cross_reference: EMAPA:18425
database_cross_reference: FBbt:00100317
database_cross_reference: FMA:7146
database_cross_reference: FMA:86294
database_cross_reference: HAO:0000375
database_cross_reference: MA:0003038
database_cross_reference: MAT:0000021
database_cross_reference: MIAA:0000021
database_cross_reference: NCIT:C13319
database_cross_reference: OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C1285092
database_cross_reference: WikipediaCategory:Glands
database_cross_reference: galen:Gland
has_exact_synonym: glandular organ
has_obo_namespace: uberon
has_related_synonym: Druese
has_related_synonym: glandula
id: UBERON:0002530
in_subset: efo slim
in_subset: pheno slim
in_subset: uberon slim

tectopontine tract
type: Class
subclass of: tract of brain
imported from: uberon.owl
database_cross_reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0228403
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/3301002
database_cross_reference: BIRNLEX:701
database_cross_reference: DHBA:12364
database_cross_reference: FMA:72505
database_cross_reference: UMLS:C0228403
has_exact_synonym: fibrae tectopontinae
has_exact_synonym: tectopontine fibers
has_exact_synonym: tectopontine fibres
has_obo_namespace: uberon
has_related_synonym: tractus tectopontinus
id: UBERON:0002930

compound organ
type: Class
subclass of: organ
definition: Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
curator note: this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs
imported from: uberon.owl
database_cross_reference: AAO:0010015
database_cross_reference: AEO:0000024
database_cross_reference: BILA:0000024
database_cross_reference: CARO:0000024
database_cross_reference: EHDAA2:0003024
database_cross_reference: HAO:0000024
database_cross_reference: TADS:0000598
database_cross_reference: TAO:0000496
database_cross_reference: TGMA:0001837
database_cross_reference: VHOG:0001723
database_cross_reference: XAO:0003041
database_cross_reference: ZFA:0000496
has_obo_namespace: uberon
has_related_synonym: organ
id: UBERON:0003103
in_subset: organ slim
in_subset: upper level

skull
type: Class
subclass of: subdivision of skeletal system
subclass of: structure with developmental contribution from neural crest
definition: Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].
imported from: uberon.owl
present_in_taxon: NCBITaxon 7762
external_ontology_notes: in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible.
external_ontology_notes: in many ontologies, the structure called the cranium is inclusive of the mandible/lower jaw skeleton
terminology_notes: A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates
database_cross_reference: Skull
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0037303
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/110530005
database_cross_reference: BTO:0001295
database_cross_reference: CALOHA:TS-2344
database_cross_reference: EHDAA2:0000325
database_cross_reference: EMAPA:17680
database_cross_reference: FMA:46565
database_cross_reference: GAID:82
database_cross_reference: MESH:D012886
database_cross_reference: NCIT:C12789
database_cross_reference: OpenCyc:Mx4rvVjOsZwpEbGdrcN5Y29ycA
database_cross_reference: UMLS:C0037303
database_cross_reference: WikipediaCategory:Skull
database_cross_reference: galen:Skull
has_obo_namespace: uberon
has_related_synonym: cranial skeleton
has_related_synonym: skeletal system of head
id: UBERON:0003129
in_subset: pheno slim
in_subset: uberon slim

heart blood vessel
type: Class
subclass of: thoracic segment blood vessel
subclass of: coronary vessel
definition: A blood vessel that is part of a heart [Automatically generated definition].
imported from: uberon.owl
database_cross_reference: EMAPA:35397
database_cross_reference: MA:0002483
has_exact_synonym: blood vessel of heart
has_obo_namespace: uberon
has_related_synonym: cardiac blood vessel
id: UBERON:0003498
in_subset: pheno slim

arterial blood vessel
type: Class
subclass of: blood vessel
definition: A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.
imported from: uberon.owl
database_cross_reference: EMAPA:35144
database_cross_reference: MA:0000061
has_obo_namespace: uberon
id: UBERON:0003509
in_subset: pheno slim
comment: only in MA - supertype of artery, arteriole, aorta.

trunk blood vessel
type: Class
subclass of: blood vessel
definition: A blood vessel that is part of a trunk [Automatically generated definition].
imported from: uberon.owl
database_cross_reference: EMAPA:37237
database_cross_reference: MA:0000511
has_exact_synonym: blood vessel of torso
has_exact_synonym: blood vessel of trunk
has_exact_synonym: torso blood vessel
has_obo_namespace: uberon
id: UBERON:0003513

temporomandibular joint
type: Class
subclass of: structure with developmental contribution from neural crest
subclass of: joint connecting upper and lower jaws
subclass of: lateral structure
definition: A synovial joint of the jaw that connects the mandible to the temporal bone.
imported from: uberon.owl
database_cross_reference: Temporomandibular joint
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0039493
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/181814009
database_cross_reference: BTO:0003674
database_cross_reference: EMAPA:19196
database_cross_reference: FMA:54832
database_cross_reference: GAID:272
database_cross_reference: MA:0002899
database_cross_reference: MESH:D013704
database_cross_reference: NCIT:C32888
database_cross_reference: UMLS:C0039493
has_exact_synonym: TMJ
has_exact_synonym: temperomandibular joint
has_obo_namespace: uberon
has_related_synonym: articulatio temporomandibularis
has_related_synonym: dentary-squamosal joint
has_related_synonym: squamosal-dentary joint
has_related_synonym: tempero-mandibular joint
has_related_synonym: temporalmandibular joint
has_related_synonym: temporomandibular
has_related_synonym: temporomandibular articulation
has_related_synonym: temporomandibular joint
id: UBERON:0003700
in_subset: pheno slim
comment: There are two TMJs, one on either side, working in unison. The unique feature of the TMJs is the articular disc. The disc is composed of fibrocartilagenous tissue (like the firm and flexible elastic cartilage of the ear) which is positioned between the two bones that form the joint. The TMJs are one of the only synovial joints in the human body with an articular disc, another being the sternoclavicular joint. The disc divides each joint into two. The lower joint compartment formed by the mandible and the articular disc is involved in rotational movement -- this is the initial movement of the jaw when the mouth opens. The upper joint compartment formed by the articular disk and the temporal bone is involved in translational movement -- this is the secondary gliding motion of the jaw as it is opened widely. The part of the mandible which mates to the under-surface of the disc is the condyle and the part of the temporal bone which mates to the upper surface of the disk is the glenoid (or mandibular) fossa[WP].
label: 颞下颌关节 @zh

thoracic segment blood vessel
type: Class
subclass of: trunk blood vessel
definition: A blood vessel that is part of a thorax [Automatically generated definition].
imported from: uberon.owl
database_cross_reference: EMAPA:37238
database_cross_reference: MA:0000558
has_exact_synonym: blood vessel of thorax
has_exact_synonym: thorax blood vessel
has_obo_namespace: uberon
has_related_synonym: upper body blood vessel
id: UBERON:0003834

reproductive gland
type: Class
subclass of: gland
subclass of: reproductive structure
definition: Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.
imported from: uberon.owl
database_cross_reference: MA:0001751
has_exact_synonym: genitalia gland
has_exact_synonym: gland of genitalia
has_exact_synonym: gland of reproductive system
has_exact_synonym: reproductive gland
has_exact_synonym: reproductive system gland
has_exact_synonym: sex gland
has_obo_namespace: uberon
id: UBERON:0003937
in_subset: organ slim
in_subset: pheno slim

anatomical conduit
type: Class
subclass of: multicellular anatomical structure
definition: Any tube, opening or passage that connects two distinct anatomical spaces.
imported from: uberon.owl
external_ontology_notes: FMA has both conduit and conduit space. In EHDAA2 this is a surface feature
database_cross_reference: Foramen
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/346902003
database_cross_reference: AEO:0000080
database_cross_reference: EHDAA2:0003080
database_cross_reference: FMA:242873
has_narrow_synonym: foramen
has_narrow_synonym: foramina
has_obo_namespace: uberon
has_related_synonym: opening
has_related_synonym: ostia
has_related_synonym: ostium
id: UBERON:0004111

endoderm-derived structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that develops (entirely or partially) from the endoderm.
curator note: Grouping term for query purposes
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0004119
in_subset: grouping class

mesoderm-derived structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that develops (entirely or partially) from the mesoderm.
curator note: Grouping term for query purposes
imported from: uberon.owl
database_cross_reference: FBbt:00025998
has_exact_synonym: mesodermal derivative
has_obo_namespace: uberon
id: UBERON:0004120
in_subset: grouping class

ectoderm-derived structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that develops (entirely or partially) from the ectoderm.
curator note: Grouping term for query purposes
imported from: uberon.owl
database_cross_reference: FBbt:00025990
has_exact_synonym: ectodermal deriviative
has_obo_namespace: uberon
id: UBERON:0004121
in_subset: grouping class

cardiac chamber
type: Class
subclass of: organ part
subclass of: mesoderm-derived structure
definition: A cardiac chamber surrounds an enclosed cavity within the heart
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/276456008
database_cross_reference: FMA:7095
database_cross_reference: OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw
has_exact_synonym: chamber of heart
has_exact_synonym: heart chamber
has_obo_namespace: uberon
id: UBERON:0004151
comment: generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus

blood vessel smooth muscle
type: Class
subclass of: smooth muscle tissue
definition: smooth muscle found within, and composing the majority of the wall of blood vessels.
imported from: uberon.owl
function_notes: Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension.
has_alternative_id: UBERON:0010508
database_cross_reference: Vascular smooth muscle
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1519956
database_cross_reference: BTO:0001431
database_cross_reference: CALOHA:TS-1107
database_cross_reference: EMAPA:35177
database_cross_reference: MA:0000710
database_cross_reference: MESH:D009131
database_cross_reference: NCIT:C33853
database_cross_reference: TAO:0005321
database_cross_reference: UMLS:C1519956
database_cross_reference: ZFA:0005321
has_exact_synonym: blood vessel involuntary muscle
has_exact_synonym: blood vessel non-striated muscle
has_exact_synonym: blood vessel smooth muscle tissue
has_exact_synonym: involuntary muscle of blood vessel
has_exact_synonym: non-striated muscle of blood vessel
has_exact_synonym: smooth muscle of blood vessel
has_exact_synonym: smooth muscle tissue of blood vessel
has_exact_synonym: vascular smooth muscle
has_exact_synonym: vascular smooth muscle tissue
has_obo_namespace: uberon
id: UBERON:0004237
in_subset: pheno slim

arterial system
type: Class
subclass of: vascular system
definition: The part of the cardiovascular system consisting of all arteries.
imported from: uberon.owl
homology_notes: The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG]
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362030008
database_cross_reference: BTO:0004690
database_cross_reference: EHDAA2:0000143
database_cross_reference: EHDAA:396
database_cross_reference: EMAPA:16201
database_cross_reference: EMAPA:16371
database_cross_reference: MA:0002719
database_cross_reference: VHOG:0000273
has_obo_namespace: uberon
id: UBERON:0004572
in_subset: pheno slim

systemic artery
type: Class
subclass of: artery
definition: An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.
imported from: uberon.owl
database_cross_reference: Systemic arteries
database_cross_reference: EMAPA:37126
database_cross_reference: FMA:66464
has_exact_synonym: systemic arterial subtree
has_obo_namespace: uberon
id: UBERON:0004573
in_subset: pheno slim

skeletal tissue
type: Class
subclass of: connective tissue
definition: A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
imported from: uberon.owl
external_definition: A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/309311006
database_cross_reference: EMAPA:37744
database_cross_reference: MA:0003047
database_cross_reference: VSAO:0000015
database_cross_reference: XAO:0004038
database_cross_reference: ZFA:0005619
has_obo_namespace: uberon
id: UBERON:0004755
comment: Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from

skeletal element
type: Class
subclass of: organ
definition: Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
imported from: uberon.owl
external_definition: Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
external_definition: Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
database_cross_reference: AAO:0011129
database_cross_reference: TAO:0001890
database_cross_reference: VSAO:0000128
database_cross_reference: XAO:0004012
database_cross_reference: ZFA:0005494
database_cross_reference: galen:SkeletalStructure
has_obo_namespace: uberon
id: UBERON:0004765
in_subset: organ slim
in_subset: uberon slim

articulation
type: Class
subclass of: multi organ part structure
definition: Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts.
imported from: uberon.owl
database_cross_reference: FBbt:00005811
has_narrow_synonym: joint
has_obo_namespace: uberon
id: UBERON:0004905
in_subset: grouping class

subdivision of digestive tract
type: Class
subclass of: subdivision of tube
definition: A proximal-distal subdivision of the digestive tract.
curator note: intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct.
imported from: uberon.owl
database_cross_reference: FBbt:00100315
database_cross_reference: FMA:71131
has_obo_namespace: uberon
has_related_synonym: alimentary system subdivision
has_related_synonym: intestinal tract
has_related_synonym: segment of intestinal tract
has_related_synonym: subdivision of alimentary system
id: UBERON:0004921
in_subset: non informative

zone of long bone
type: Class
subclass of: zone of bone organ
definition: An organ part that is part of a long bone [Automatically generated definition].
imported from: uberon.owl
database_cross_reference: FMA:24008
has_exact_synonym: long bone zone
has_obo_namespace: uberon
id: UBERON:0005055
in_subset: uberon slim

muscle structure
type: Class
subclass of: anatomical structure
definition: Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].
curator note: in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila
imported from: uberon.owl
database_cross_reference: EMAPA:32715
database_cross_reference: FBbt:00005073
database_cross_reference: FMA:30316
has_exact_synonym: musculus
has_obo_namespace: uberon
has_related_synonym: muscle
has_related_synonym: muscle element
id: UBERON:0005090

reproductive structure
type: Class
subclass of: multicellular anatomical structure
definition: Any anatomical structure that is part of the reproductive system.
imported from: uberon.owl
has_exact_synonym: reproductive system element
has_exact_synonym: reproductive system structure
has_obo_namespace: uberon
id: UBERON:0005156
in_subset: grouping class

multi cell part structure
type: Class
subclass of: anatomical cluster
definition: A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.
imported from: uberon.owl
external_ontology_notes: we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'
database_cross_reference: AAO:0011000
database_cross_reference: CARO:0001000
database_cross_reference: FBbt:00007060
database_cross_reference: FMA:83115
has_exact_synonym: multi-cell-component structure
has_exact_synonym: multi-cell-part structure
has_obo_namespace: uberon
has_related_synonym: cell part cluster
id: UBERON:0005162
in_subset: upper level

abdomen element
type: Class
subclass of: abdominal segment element
definition: An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272631008
database_cross_reference: MA:0000522
has_exact_synonym: abdomen organ
has_obo_namespace: uberon
id: UBERON:0005172
in_subset: non informative

abdominal segment element
type: Class
subclass of: trunk region element
definition: An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.
imported from: uberon.owl
database_cross_reference: EMAPA:37062
database_cross_reference: MA:0000529
has_exact_synonym: abdominal segment organ
has_obo_namespace: uberon
id: UBERON:0005173
in_subset: non informative

trunk region element
type: Class
subclass of: organ
definition: An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.
imported from: uberon.owl
database_cross_reference: EMAPA:37270
database_cross_reference: MA:0000516
has_exact_synonym: trunk organ
has_obo_namespace: uberon
id: UBERON:0005177
in_subset: non informative
in_subset: organ slim

thoracic cavity element
type: Class
subclass of: viscus
subclass of: thoracic segment organ
definition: An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.
imported from: uberon.owl
database_cross_reference: EMAPA:37273
database_cross_reference: MA:0000557
has_exact_synonym: thoracic cavity organ
has_obo_namespace: uberon
id: UBERON:0005178
in_subset: non informative
in_subset: pheno slim

thoracic segment organ
type: Class
subclass of: trunk region element
definition: An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.
imported from: uberon.owl
database_cross_reference: EMAPA:37271
database_cross_reference: MA:0000563
has_obo_namespace: uberon
has_related_synonym: upper body organ
id: UBERON:0005181
in_subset: non informative

male reproductive gland
type: Class
subclass of: reproductive gland
definition: A sex gland that is part of a male reproductive system.
imported from: uberon.owl
database_cross_reference: BTO:0000080
database_cross_reference: EMAPA:19285
database_cross_reference: MA:0000399
has_obo_namespace: uberon
has_related_synonym: accessory sex gland
id: UBERON:0005399
in_subset: organ slim
in_subset: pheno slim

alimentary part of gastrointestinal system
type: Class
subclass of: anatomical system
definition: The part of the digestive system that excludes the hepatobiliary system.
editor note: the decision to split digestive and gastrointestinal in this way may be revisited. As it currently stands, this class more closely aligns what MA calls the alimentary system
imported from: uberon.owl
external_definition: The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas[ncithesaurus:Gastrointestinal_System].
homology_notes: All metazoans (with degenerate exceptions) have some sort of digestive cavity with a means of entrance to and exit from it.[well established][VHOG]
external_ontology_notes: that many anatomy ontologies consider this synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class. We have one entity that is part of both gastrointestinal and hepatobiliary systems: hepatopancreatic ampulla.
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0012240
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/373871007
database_cross_reference: BTO:0000058
database_cross_reference: CALOHA:TS-0407
database_cross_reference: EHDAA2:0000110
database_cross_reference: EHDAA:514
database_cross_reference: EMAPA:16246
database_cross_reference: EV:0100056
database_cross_reference: FMA:71132
database_cross_reference: GAID:294
database_cross_reference: MA:0000323
database_cross_reference: MESH:A03.492
database_cross_reference: NCIT:C12378
database_cross_reference: UMLS:C0012240
database_cross_reference: VHOG:0000412
database_cross_reference: galen:GastrointestinalTract
has_obo_namespace: uberon
has_related_synonym: GI tract
has_related_synonym: alimentary system
has_related_synonym: alimentary tract
has_related_synonym: gastro-intestinal system
has_related_synonym: gastroenterological system
has_related_synonym: gastrointestinal (GI) tract
has_related_synonym: gastrointestinal system
has_related_synonym: gastrointestinal tract
id: UBERON:0005409
in_subset: pheno slim

duct of male reproductive system
type: Class
subclass of: duct
subclass of: reproductive structure
definition: Any of the ducts that are part of a male reproductive system.
curator note: this class groups the individual ducts in a variety of species
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0005904
in_subset: grouping class

zone of bone organ
type: Class
subclass of: zone of organ
imported from: uberon.owl
database_cross_reference: FMA:10483
has_exact_synonym: bone organ zone
has_obo_namespace: uberon
id: UBERON:0005913

coronary vessel
type: Class
subclass of: vessel
subclass of: mesoderm-derived structure
definition: Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation
editor note: TODO - change relation from part_of
imported from: uberon.owl
database_cross_reference: Coronary circulation
database_cross_reference: MESH:D003331
has_obo_namespace: uberon
id: UBERON:0005985
in_subset: pheno slim

multi-limb segment region
type: Class
subclass of: subdivision of organism along appendicular axis
definition: A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions).
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0006058
in_subset: non informative

bodily fluid
type: Class
subclass of: organism substance
definition: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
imported from: uberon.owl
has_broad_synonym: fluid
database_cross_reference: Body fluid
database_cross_reference: BIRNLEX:20
database_cross_reference: EMAPA:37441
database_cross_reference: FMA:280556
database_cross_reference: GAID:266
database_cross_reference: MESH:D001826
database_cross_reference: galen:BodyFluid
has_exact_synonym: body fluid
has_obo_namespace: uberon
id: UBERON:0006314
in_subset: pheno slim

digestive system gland
type: Class
subclass of: endocrine gland
subclass of: digestive system element
definition: Any gland that is part of the digestive system.
imported from: uberon.owl
database_cross_reference: AAO:0000130
database_cross_reference: BTO:0000345
has_obo_namespace: uberon
has_related_synonym: digestive gland
id: UBERON:0006925
in_subset: organ slim

primary circulatory organ
type: Class
subclass of: circulatory organ
definition: A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
imported from: uberon.owl
taxon_notes: note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
database_cross_reference: FBbt:00003154
database_cross_reference: SPD:0000130
database_cross_reference: TADS:0000147
has_narrow_synonym: dorsal tube
has_narrow_synonym: heart
has_obo_namespace: uberon
has_related_synonym: adult heart
id: UBERON:0007100
in_subset: grouping class
comment: Gene notes: Bmp, Nkx, Gata

neck of femur
type: Class
subclass of: mesoderm-derived structure
subclass of: zone of long bone
subclass of: neck of bone element
definition: The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward.
imported from: uberon.owl
database_cross_reference: Femur neck
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0015815
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/361792007
database_cross_reference: FMA:42385
database_cross_reference: GAID:201
database_cross_reference: MESH:A02.835.232.500.247.510
database_cross_reference: NCIT:C61563
database_cross_reference: UMLS:C0015815
database_cross_reference: galen:NeckOfFemur
has_exact_synonym: femoral neck
has_obo_namespace: uberon
has_related_synonym: collum femoris
has_related_synonym: femur neck
has_related_synonym: neck of the femur
id: UBERON:0007119
in_subset: pheno slim

tract of brain
type: Class
subclass of: axon tract
definition: An axon tract that is part of a brain.
editor note: the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts
imported from: uberon.owl
database_cross_reference: FMA:83848
has_exact_synonym: brain tract
has_obo_namespace: uberon
has_related_synonym: landmark tracts
id: UBERON:0007702

vascular system
type: Class
subclass of: anatomical system
definition: Anatomical system that consists of all blood and lymph vessels.
editor note: consider merging with vasculature
imported from: uberon.owl
external_definition: The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
external_ontology_notes: in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C0489903
database_cross_reference: BTO:0001085
database_cross_reference: CALOHA:TS-2053
database_cross_reference: EHDAA2:0004520
database_cross_reference: EMAPA:35905
database_cross_reference: MA:0002718
database_cross_reference: NCIT:C33854
database_cross_reference: UMLS:C0489903
has_obo_namespace: uberon
has_related_synonym: Gefaesssystem@de
id: UBERON:0007798
in_subset: pheno slim

lower limb segment
type: Class
subclass of: limb segment
definition: A limb segment that is part of a hindlimb.
imported from: uberon.owl
database_cross_reference: FMA:24877
has_exact_synonym: free lower limb segment
has_exact_synonym: free lower limb subdivision
has_exact_synonym: segment of free lower limb
has_exact_synonym: subdivision of free lower limb
has_obo_namespace: uberon
id: UBERON:0008784

subdivision of trunk
type: Class
subclass of: organism subdivision
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/22943007
database_cross_reference: FMA:25054
has_exact_synonym: region of trunk
has_exact_synonym: trunk subdivision
has_obo_namespace: uberon
id: UBERON:0009569
in_subset: non informative

sac
type: Class
subclass of: anatomical structure
imported from: uberon.owl
database_cross_reference: galen:Diverticulum
has_exact_synonym: pouch
has_obo_namespace: uberon
has_related_synonym: diverticulum
id: UBERON:0009856

multicellular anatomical structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has more than one cell as a part.
imported from: uberon.owl
database_cross_reference: CARO:0010000
database_cross_reference: FBbt:00100313
has_exact_synonym: multicellular structure
has_obo_namespace: uberon
id: UBERON:0010000
in_subset: upper level

food storage organ
type: Class
subclass of: digestive system element
definition: An organ of the digestive tract that is capable of retaining and storing food
curator note: This is a very broad functionally defined grouping class that collects disparate structures from insects to vertebrates
imported from: uberon.owl
database_cross_reference: BSA:0000123
database_cross_reference: TADS:0000172
database_cross_reference: TGMA:0001041
has_obo_namespace: uberon
id: UBERON:0010039
in_subset: functional classification
in_subset: grouping class

male accessory sex gland
type: Class
subclass of: male reproductive gland
definition: Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male.
imported from: uberon.owl
database_cross_reference: BTO:0004798
has_obo_namespace: uberon
has_related_synonym: male accessory gland
has_related_synonym: male accessory reproductive gland
id: UBERON:0010147
in_subset: pheno slim

structure with developmental contribution from neural crest
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has some part that develops from the neural crest.
curator note: Grouping term for query purposes
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0010314
in_subset: grouping class

paired limb/fin segment
type: Class
subclass of: subdivision of organism along appendicular axis
definition: An appendage segment that is part of a limb/fin.
imported from: uberon.owl
has_exact_synonym: limb/fin segment
has_obo_namespace: uberon
id: UBERON:0010538
in_subset: homology grouping

subdivision of organism along appendicular axis
type: Class
subclass of: organism subdivision
definition: A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg.
imported from: uberon.owl
database_cross_reference: FBbt:00007018
has_exact_synonym: appendage segment
has_exact_synonym: appendicular segment
has_obo_namespace: uberon
id: UBERON:0010758
in_subset: upper level

joint connecting upper and lower jaws
type: Class
subclass of: synovial joint
definition: Synovial joint that articulates bones of upper and lower jaw.
imported from: uberon.owl
taxon_notes: Some synapsids retained two pairs of jaw joints - quadrate-articular and tempero-mandibular, but this unusual paired condition did not last long
has_broad_synonym: jaw joint
database_cross_reference: NCIT:C32888
has_narrow_synonym: craniomandibular joint
has_obo_namespace: uberon
id: UBERON:0011171

central nervous system cell part cluster
type: Class
subclass of: multi cell part structure
definition: A multi cell part structure that is part of a central nervous system.
imported from: uberon.owl
database_cross_reference: FMA:83143
has_exact_synonym: cell part cluster of neuraxis
has_exact_synonym: neuraxis layer
has_obo_namespace: uberon
id: UBERON:0011215
in_subset: upper level

organ system subdivision
type: Class
subclass of: multicellular anatomical structure
definition: A subdivision of an anatomical system.
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/91690000
database_cross_reference: FBbt:00007330
database_cross_reference: FMA:67509
has_obo_namespace: uberon
id: UBERON:0011216
in_subset: upper level

subdivision of organism along main body axis
type: Class
subclass of: organism subdivision
definition: A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.
editor note: Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem
imported from: uberon.owl
has_exact_synonym: axial subdivision of organism
has_obo_namespace: uberon
has_related_synonym: body segment
has_related_synonym: main body segment
id: UBERON:0011676
in_subset: upper level

head or neck skin
type: Class
subclass of: zone of skin
definition: A zone of skin that is part of a craniocervical region.
imported from: uberon.owl
database_cross_reference: http://linkedlifedata.com/resource/umls/id/C1522650
database_cross_reference: EMAPA:37276
database_cross_reference: MA:0000574
database_cross_reference: NCIT:C12294
database_cross_reference: UMLS:C1522650
has_obo_namespace: uberon
id: UBERON:0012180

subdivision of oviduct
type: Class
subclass of: reproductive structure
subclass of: subdivision of tube
definition: A section through the tube or network of tubes that connects the ovaries to the outside of the body.
imported from: uberon.owl
external_ontology_notes: FMA class may only represent the uterine portion
database_cross_reference: FMA:18302
has_exact_synonym: subdivision of oviduct
has_exact_synonym: subdivision of uterine tube
has_exact_synonym: uterine tube zone
has_exact_synonym: zone of uterine tube
has_narrow_synonym: subdivision of fallopian tube
has_obo_namespace: uberon
id: UBERON:0013515
in_subset: non informative

subdivision of tube
type: Class
subclass of: organ part
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0013522

body proper
type: Class
subclass of: organism subdivision
definition: The region of the organism associated with the visceral organs.
imported from: uberon.owl
external_definition: Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424].
database_cross_reference: AEO:0000103
database_cross_reference: BTO:0001489
database_cross_reference: EMAPA:36031
database_cross_reference: FMA:231424
has_obo_namespace: uberon
has_related_synonym: body
has_related_synonym: whole body
id: UBERON:0013702
in_subset: non informative

arterial blood
type: Class
subclass of: blood
definition: A blood that is part of a artery.
imported from: uberon.owl
database_cross_reference: FMA:83066
has_exact_synonym: arterial blood
has_exact_synonym: blood in artery
has_exact_synonym: portion of arterial blood
has_obo_namespace: uberon
id: UBERON:0013755
in_subset: pheno slim

digestive system element
type: Class
subclass of: organ
definition: Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/272627002
database_cross_reference: EMAPA:37843
has_exact_synonym: digestive organ
has_exact_synonym: digestive system organ
has_obo_namespace: uberon
id: UBERON:0013765
in_subset: grouping class
in_subset: pheno slim

lateral structure
type: Class
subclass of: anatomical structure
definition: Any structure that is placed on one side of the left-right axis of a bilaterian.
curator note: This class is primarily to implement taxon constraints. It may be removed in the future.
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0015212
in_subset: grouping class
in_subset: non informative

circulatory organ
type: Class
subclass of: compound organ
definition: A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.
imported from: uberon.owl
has_broad_synonym: heart
database_cross_reference: SPD:0000130
has_exact_synonym: cardiac pump
has_exact_synonym: heart or heart like organ
has_narrow_synonym: circulatory vessel
has_obo_namespace: uberon
has_related_synonym: cardiac structure
id: UBERON:0015228
in_subset: grouping class

neck of bone element
type: Class
subclass of: neck of organ
subclass of: zone of bone organ
definition: the neck region of a bone organ.
imported from: uberon.owl
has_exact_synonym: bone neck
has_exact_synonym: neck of bone
has_obo_namespace: uberon
id: UBERON:0018664

bladder organ
type: Class
subclass of: cavitated compound organ
subclass of: sac
definition: A membranous sac in animals that serves as the receptacle of a liquid or contains gas.
imported from: uberon.owl
database_cross_reference: BTO:0000123
has_narrow_synonym: bladder
has_obo_namespace: uberon
id: UBERON:0018707

multi organ part structure
type: Class
subclass of: multicellular anatomical structure
definition: An multicellular anatomical structure that has subparts of multiple organs as a part.
imported from: uberon.owl
database_cross_reference: CARO:0020001
has_obo_namespace: uberon
has_related_synonym: anatomical cluster
id: UBERON:0034921

anatomical collection
type: Class
subclass of: material anatomical entity
definition: A collection of anatomical structures that are alike in terms of their morphology or developmental origin.
editor note: resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0034925

external soft tissue zone
type: Class
subclass of: multicellular anatomical structure
definition: A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0034929

zone of organ
type: Class
subclass of: organ part
imported from: uberon.owl
database_cross_reference: FMA:55268
has_exact_synonym: organ sector
has_exact_synonym: organ zonal region
has_exact_synonym: organ zone
has_obo_namespace: uberon
has_related_synonym: organ region with floating fiat boundary
id: UBERON:0034944

left cardiac chamber
type: Class
subclass of: cardiac chamber
subclass of: lateral structure
definition: Any chamber of the left side of the heart
imported from: uberon.owl
database_cross_reference: http://www.snomedbrowser.com/Codes/Details/362008007
database_cross_reference: FMA:7166
has_obo_namespace: uberon
id: UBERON:0035553

phenotype
type: Class
subclass of: quality
imported from: OBO Relations Ontology

encounter for prophylactic measures, unspecified
type: Class
subclass of: disease process
definition: Actions done to prevent a disease or to relieve a symptom i.e.: Surgery to remove blood clots
definition editor: Justin Song
definition source: mchp-appserv.cpe.umanitoba.ca
has icd10 code: Z29.0
id: ICDO_0000374

acculturation difficulty
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: having problems or an inability adapting to a new environment or culture
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z60-/Z60.3
has icd10 code: Z60.3
id: ICDO_0000375

asymptomatic human immunodeficiency virus [HIV] infection status
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: no symptoms, but HIV was found in patient's bloodstream
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z21-/Z21
has icd10 code: Z21
id: ICDO_0000376

blood transfusion without reported diagnosis
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: code that can be used to indicate a diagnosis for reimbursement purposes. code that can be used to indicate a diagnosis for reimbursement purposes.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z51-/Z51.89
has icd10 code: Z51.3
id: ICDO_0000377

care involving use of other rehabilitation procedures
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Care involving use of other rehabilitation procedures
definition editor: Justin Song, Virginia He
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: Z50.8
id: ICDO_0000378

other physical therapy
type: Class
subclass of: care involving use of other rehabilitation procedures
definition: the treatment of disease, injury, or deformity by physical methods rather than by drugs or surgery.
definition editor: Justin Song, Virginia He
definition source: https://medcode.ch/us/en/icds/ICD10-2016/Z50.1
has icd10 code: Z50.1
id: ICDO_0000379

contact with and (suspected) exposure to other communicable diseases
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Patient is thought to have been exposed to the virus in question
definition: code is used to show that patient has probably been infected because they have been exposed to the infection
definition editor: Justin Song
definition source: https://www.aafp.org/journals/fpm/blogs/gettingpaid/entry/coronavirus_diagnosis_coding.html
definition source: https://www.icd10monitor.com/covid-19-coding-dilemma-z20-828-and-z03-818
has icd10 code: Z20.8
has icd10 code: Z20.828
id: ICDO_0000380
label: contact with and (suspected) exposure to other viral communicable diseases

observation for suspected disease or condition, unspecified
type: Class
subclass of: contact with and (suspected) exposure to other communicable diseases
definition: patient kept under observation for suspected disease/condition
definition editor: Justin Song, Virginia He
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: Z03.9

counseling, unspecified
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: the provision of assistance and guidance in resolving personal, social, or psychological problems and difficulties, especially by a professional.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z71-/Z71.9
has icd10 code: Z71.9

dietary counseling and surveillance
type: Class
subclass of: counseling, unspecified
definition: help with diet means the person is not eating healthy.
definition editor: Justin Song
definition source: http://www.healthyct.org/files/2015/12/Nutritional-Diet-Counseling_Benefit-Payment-Guideline-__FINAL.pdf
has icd10 code: Z71.3

other specified counseling
type: Class
subclass of: counseling, unspecified
definition: a medical diagnosis of other specified counseling
definition editor: Justin Song, Virginia He
definition source: https://icdlist.com/icd-10/Z71.89
has icd10 code: Z71.89

encounter for antineoplastic chemotherapy and immunotherapy
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Encounter for antineoplastic chemotherapy and immunotherapy
definition: the treatment of disease by the use of chemical substances, especially the treatment of cancer by cytotoxic and other drugs.
definition editor: Justin Song, Virginia He
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z51-/Z51.1
has icd10 code: Z51.1
has icd10 code: Z51.2
id: ICDO_0000386
label: other chemotherapy

encounter for observation for other suspected diseases and conditions ruled out
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: patient under observation for other suspected diseases and conditions
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z03-/Z03.8
has icd10 code: Z03.8
id: ICDO_0000386

encounter for observation for suspected exposure to other biological agents ruled out
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: encounter for observation due to suspected exposure to biological agents
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z03-/Z03.818
has icd10 code: Z03.818
id: ICDO_0000387

encounter for other specified aftercare
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Encounter for other specified aftercare
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z51-/Z51.8
has icd10 code: Z51.8
id: ICDO_0000388

encounter for fitting and adjustment of extracorporeal dialysis catheter
type: Class
subclass of: encounter for other specified aftercare
definition: Encounter for fitting and adjustment of extracorporeal dialysis catheter
definition editor: Justin Song, Virginia He
definition source: https://icd.codes/icd10cm/Z4901#:~:text=MS%2DDRG%20codes.-,Z49.,to%20specify%20a%20medical%20diagnosis.
has icd10 code: Z49.1
id: ICDO_0000389

encounter for fitting and adjustment of urinary device
type: Class
subclass of: encounter for other specified aftercare
definition: unirary device needs replacement
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z46-/Z46.6
has icd10 code: Z46.6
id: ICDO_0000390

encounter for palliative care
type: Class
subclass of: encounter for other specified aftercare
definition: improves the quality of life of patients and their families facing the problem associated with life-threatening illness
definition editor: Justin Song, Virginia He
definition source: https://icdlist.com/icd-10/Z51.5
has icd10 code: Z51.5
id: ICDO_0000391

follow-up examination after other treatment for other conditions
type: Class
subclass of: encounter for other specified aftercare
definition: Follow-up examination after other treatment for other conditions
definition editor: Justin Song, Virginia He
definition source: https://icd.codes/icd10cm/Z09
has icd10 code: Z09.8

encounter for screening, unspecified
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: screening is done to prevent a disease or to help identify the disease.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z13-
has icd10 code: Z13.9
id: ICDO_0000393

encounter for screening for respiratory disorder NEC
type: Class
subclass of: encounter for screening, unspecified
definition: screening for respiratory condition
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z13-/Z13.83
has icd10 code: Z13.83
id: ICDO_0000394

homelessness
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Persons lacking permanent or reliable shelter, variously due to poverty, lack of affordable housing, mental illness, substance abuse, juvenile alienation, or other factors.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.0
has icd10 code: Z59.0
id: ICDO_0000395

inadequate housing
type: Class
subclass of: homelessness
definition: used to specify what condition the patient is under
definition editor: Justin Song
definition source: http://resources.hwb.wales.gov.uk/VTC/2012-13/22032013/hsc/eng/unit-4/u4-rthawb/u4-rthawb12.htm#:~:text=Inadequate%20housing%20is%20housing%20that,Unsafe%20%E2%80%93%20need%20repairs%2C%20electrical%20faults
has icd10 code: Z59.1
id: ICDO_0000396

person awaiting admission to adequate facility elsewhere
type: Class
subclass of: homelessness
definition: Patient awaiting admission to adequate facility elsewhere
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z75-/Z75.1
has icd10 code: Z75.1
id: ICDO_0000397

need for assistance with personal care
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: patient needs assisstance with personal care
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.1
has icd10 code: Z74.1
id: ICDO_0000398

need for assistance at home and no other household member able to render care
type: Class
subclass of: need for assistance with personal care
definition: the patient needs help living everyday life at home.
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/Z742#:~:text=Disorders%2C%20Version%205)-,Z74.,to%20specify%20a%20medical%20diagnosis.
has icd10 code: Z74.2
id: ICDO_0000399

reduced mobility
type: Class
subclass of: need for assistance with personal care
definition: patient whose mobility is reduced
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.0
has icd10 code: Z74.0
id: ICDO_0000400

persons encountering health services in other specified circumstances
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: person is disabled physically or mentally, so they are in need of medical services
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/Z7689
has icd10 code: Z76.8
id: ICDO_0000401

long term (current) use of insulin
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: used to specify that the patient has used insulin. This can help identify diseases
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/Z794
has icd10 code: Z79.4
id: ICDO_0000402

other long term (current) drug therapy
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: Therapeutic drug induced immunosuppression, long term use
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z79-/Z79.899
has icd10 code: Z79.899
id: ICDO_0000403

presence of coronary angioplasty implant and graft
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: a procedure used to widen blocked or narrowed coronary arteries
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.5
has icd10 code: Z95.5
id: ICDO_0000404

presence of orthopedic joint implants
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: may be used to specify diseases
definition editor: Justin Song
definition source: https://icdlist.com/icd-10/Z96.698
has icd10 code: Z96.6
id: ICDO_0000405

presence of other cardiac and vascular implants and grafts
type: Class
subclass of: persons encountering health services in other specified circumstances
definition: a surgical procedure that redirects blood flow from one area of the body to another by reconnecting the blood vessels
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.8
has icd10 code: Z95.8
id: ICDO_0000406

problems related to living alone
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: someone that lives alone is more keen to become stressed, bored, or other mental states
definition editor: Justin Song
definition source: https://www.apartmenttherapy.com/5-problems-you-only-face-while-living-alone-and-how-to-deal-with-them-205760
has icd10 code: Z60.2
id: ICDO_0000407

general symptoms
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: signs such as jaw pain or chills that help identify the disease
definition source: https://icd.codes/icd10cm/R688
has icd10 code: R68.89
has ICD10 name: other general symptoms and signs
created by: Justin Song
id: ICDO_0000408

general signs
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: signs such as jaw pain or chills that help identify the disease
definition source: https://icd.codes/icd10cm/R688
has icd10 code: R68.89
has ICD10 name: other general symptoms and signs
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000409

person with feared health complaint in whom no diagnosis is made
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: a medical diagnosis of person with feared health complaint in whom no diagnosis is made.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z71-/Z71.1
has icd10 code: Z71.1
id: ICDO_0000410

nosocomial condition
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: describes the circumstance causing an injury
definition source: https://www.icd10data.com/ICD10CM/Codes/V00-Y99/Y90-Y99/Y95-/Y95
has icd10 code: Y95
created by: Justin Song
creation date: 7/25/2020
id: ICDO_0000411

abnormal electrocardiogram
type: Class
subclass of: general signs
definition: abnormal results from cardiogram
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R90-R94/R94-/R94.31
has icd10 code: R94.31
has ICD10 name: Abnormal electrocardiogram [ECG] [EKG]
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000412

abnormal findings on diagnostic imaging of lung
type: Class
subclass of: general signs
definition: Abnormal findings on diagnostic imaging of lung
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R90-R94/R91-/R91
has icd10 code: R91
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000413

other nonspecific abnormal finding of lung field
type: Class
subclass of: abnormal findings on diagnostic imaging of lung
definition: nonspecific abnormal finding of lung field
definition source: https://icdlist.com/icd-10/R91.8
has icd10 code: R91.8
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000414

abnormal levels of other serum enzymes
type: Class
subclass of: general signs
definition: this abnormal level indicates damage to the liver
definition source: https://www.mayoclinic.org/symptoms/elevated-liver-enzymes/basics/definition/sym-20050830
has icd10 code: R74.8
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000415

abnormal results of liver function studies
type: Class
subclass of: general signs
definition: tests on the patients liver have given results that are abnormal
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R90-R94/R94-/R94.5
has icd10 code: R94.5
created by: 7/23/2020
created by: Justin Song
id: ICDO_0000416

anuria and oliguria
type: Class
subclass of: general signs
definition: Oliguria is defined as a urine output that is less than 400 mL/24 h or less than 17 mL/h in adults. Anuria is defined as urine output that is less than 100 mL/24 h or 0 mL/12 h.
definition source: https://link.springer.com/chapter/10.1007/978-981-13-7677-1_25#:~:text=Oliguria%20is%20defined%20as%20a,or%200%20mL%2F12%20h.
has icd10 code: R34
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000417

bradycardia, unspecified
type: Class
subclass of: general signs
definition: Excessive slowness in the action of the heart
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R00-/R00.1
has icd10 code: R00.1
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000418

change in bowel habit
type: Class
subclass of: general signs
definition: could be a sign of bowel cancer
definition source: https://www.oncolink.org/frequently-asked-questions/cancers/what-is-meant-by-a-change-in-bowel-habits#:~:text=The%20term%20%22change%20in%20bowel,can%20do%20the%20same%20thing.
has icd10 code: R19.4
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000419

elevated blood-pressure reading, without diagnosis of hypertension
type: Class
subclass of: general signs
definition: blood pressure above 120/80 mm
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R03-/R03.0
has icd10 code: R03.0
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000420

nonspecific elevation of levels of transaminase and lactic acid dehydrogenase
type: Class
subclass of: general signs
definition: high LDH levels indicate tissue damage.
definition source: https://www.healthline.com/health/lactate-dehydrogenase-test#results
has icd10 code: R74.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000421

other abnormalities of gait and mobility
type: Class
subclass of: general signs
definition: a deviation from normal walking (gait)
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D62-/D62
has icd10 code: R26.8
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000422

other specified abnormalities of plasma proteins
type: Class
subclass of: general signs
definition: blood tests have found abnormalities of protiens in the blood which can indicate clues for a potential ilness
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R70-R79/R77-/R77.8
has icd10 code: R77.8
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000423

parageusia
type: Class
subclass of: general signs
definition: A condition characterized by alterations of the sense of taste which may range from mild to severe, including gross distortions of taste quality.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R43-/R43.2
has icd10 code: R43.2
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000424

prediabetes
type: Class
subclass of: general signs
definition: Prediabetes is when your blood sugar level is higher than it should be but not high enough for your doctor to diagnose diabetes
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R70-R79/R73-/R73.03
has icd10 code: R73.03
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000425

tachycardia, unspecified
type: Class
subclass of: general signs
definition: Abnormally rapid heartbeat, usually with a heart rate above 100 beats per minute for adults.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R00-/R00.0
has icd10 code: R00.0
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000426

unspecified urinary incontinence
type: Class
subclass of: general signs
definition: a person urinates when they do not want to
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R30-R39/R32-/R32
has icd10 code: R32
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000427

coma
type: Class
subclass of: general symptoms
definition: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R40-/R40.2
has icd10 code: R40.2
id: ICDO_0000428

dyspnea
type: Class
subclass of: general symptoms
definition: main symptom of dyspnea is labored breathing. It's definition as a word is "labored breathing"
definition source: https://www.healthline.com/health/dyspnea
has icd10 code: R06.0
created by: Justin Song
id: ICDO_0000429

dyspnea, unspecified
type: Class
subclass of: dyspnea
definition: shortness of breath
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.2
has ICD10 name: R06.00
has ICD10 name: dyspnea, unspecified
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000430

fever, unspecified
type: Class
subclass of: general symptoms
definition: Body temprature is raised to fight pathogens
has icd10 code: R50.9
created by: Justin Song
has_exact_synonym: fever
id: ICDO_0000431

drug induced fever
type: Class
subclass of: fever, unspecified
definition: a fever caused by a drug
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R50-/R50.2
has icd10 code: R50.2
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000432

specified fever
type: Class
subclass of: fever, unspecified
definition: when your temperature rises above its normal range
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R50-/R50.8
has ICD10 name: other specified fever
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000433

hemoptysis
type: Class
subclass of: general symptoms
definition: Coughing or spitting up blood from the respiratory tract.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04.2
has icd10 code: R04.2
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000434

malaise and fatigue
type: Class
subclass of: general symptoms
definition: a symptom that makes one feel weakness, discomfort, or illness
definition source: https://www.healthline.com/health/malaise
has icd10 code: R53
has ICD10 name: malaise
created by: Justin Song
creation date: 7/22/2020
has_exact_synonym: fatigue
id: ICDO_0000435

other fatigue
type: Class
subclass of: malaise and fatigue
definition: feelings of tiredness/lack of energy
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R53-/R53.83
has icd10 code: R53.83
has ICD10 name: other fatigue
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000436

other malaise
type: Class
subclass of: malaise and fatigue
definition: A disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R53-/R53.81
has icd10 code: R53.81
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000437

nausea
type: Class
subclass of: general symptoms
definition: A disorder characterized by a queasy sensation and/or the urge to vomit
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R11-/R11.0
has icd10 code: R11.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000438

nausea with vomiting
type: Class
subclass of: nausea
definition: symptoms of dizziness and vomiting that can help find the disease the patient is under
definition source: https://www.webmd.com/digestive-disorders/digestive-diseases-nausea-vomiting#1
has icd10 code: R11
has ICD10 name: nausea with vomiting
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000439

nausea with vomiting, unspecified
type: Class
subclass of: nausea with vomiting
definition: symptoms that can help find the disease the patient is under
definition source: https://www.webmd.com/digestive-disorders/digestive-diseases-nausea-vomiting#1
has icd10 code: R11.2
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000440

other shock
type: Class
subclass of: general symptoms
definition: patient is traumatized to a point that they cannot send commands to body parts
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R57-/R57.8
has icd10 code: R57.8
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000441

cardiogenic shock
type: Class
subclass of: other shock
definition: Shock resulting from primary failure of the heart in its pumping function
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R57-/R57.0
has icd10 code: R57.0
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000442

hypovolemic shock
type: Class
subclass of: other shock
definition: when a patient has lost more than 20% of their blood and he or she enter shock
definition source: https://www.healthline.com/health/hypovolemic-shock#:~:text=Hypovolemic%20shock%20is%20a%20life,can%20lead%20to%20organ%20failure.
has icd10 code: R57.1
has ICD10 name: hyopolvemic shock
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000443

septic shock
type: Class
subclass of: other shock
definition: severe and potentially fatal condition that occurs when sepsis leads to life-threatening low blood pressure.
definition source: https://www.galenreasoner.com/icd10codes/R57.2
has icd10 code: R57.2
id: ICDO_0000444

other symptoms and signs involving cognitive functions and awareness
type: Class
subclass of: general symptoms
definition: A category of mental health disorders that primarily affect cognitive abilities including learning, memory, perception, and problem solving.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R41-/R41.8
has icd10 code: R41.8
id: ICDO_0000445

pain
type: Class
subclass of: general symptoms
definition: physical suffering or discomfort caused by illness or injury
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R52-/R52
has icd10 code: R52
has ICD10 name: pain, unspecified
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000446

acute pain
type: Class
subclass of: pain
definition: pain that lasts from 3-6 months related to soft tissue
definition source: https://www.spine-health.com/glossary/acute-pain#:~:text=Acute%20pain%20is%20a%20type,as%20the%20injured%20tissues%20heal.
has icd10 code: R52.0
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000447

chest pain
type: Class
subclass of: pain
definition: pain in the chest not caused by heart disease or heart attack
definition source: https://my.clevelandclinic.org/health/diseases/15851-gerd-non-cardiac-chest-pain#:~:text=In%20most%20people%2C%20non%2Dcardiac,stress%2C%20anxiety%2C%20and%20depression.
has icd10 code: R07.4
has ICD10 name: chest pain, unspecified
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000448

chest pain, unspecified
type: Class
subclass of: chest pain
definition: pain in the chest, unspecified cause
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07.9
has icd10 code: R07.9
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000449

other chest pain
type: Class
subclass of: chest pain
definition: Usually a symptom of a disease or caused by physical damage
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07.89
has icd10 code: R07.89
has ICD10 name: other chest pain
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000450

headache
type: Class
subclass of: pain
definition: a disorder characterized by a sensation of marked discomfort in the head
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R51-/R51
has icd10 code: R51
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000451

other and unspecified abdominal pain
type: Class
subclass of: pain
definition: stomach pain or a stomachache
definition source: https://icd.codes/icd10cm/R109
has icd10 code: R10.4
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000452

other chronic pain
type: Class
subclass of: pain
definition: pain that lasts more that half a year
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has ICD10 name: R52.2
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000453

chronic intractable pain
type: Class
subclass of: other chronic pain
definition: a type of pain that can't be controlled with standard medical care
definition source: https://www.healthline.com/health/intractable-pain#:~:text=Intractable%20pain%20refers%20to%20a,intractable%20pain%20disease%2C%20or%20IP.
has icd10 code: R52.1
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000454

repeated falls
type: Class
subclass of: general symptoms
definition: A sudden movement downward (fall), usually resulting in injury.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R25-R29/R29-/R29.6
has icd10 code: R29.6
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000455

shortness of breath
type: Class
subclass of: general symptoms
definition: this is a symptom of many diseases that attack the respiratory system
definition source: https://www.healthline.com/health/coronavirus-shortness-of-breath#what-it-feels-like
has icd10 code: R06.02
created by: Justin Song
has_broad_synonym: Respiratory distress
id: ICDO_0000456

symptoms specifically associated with systemic inflammation and infection
type: Class
subclass of: general symptoms
definition: Examples: fever >38 degrees c or hypothermia <36 degrees c; tachycardia >90 beat/minute; tachypnea >24 breaths/minute; (4) leukocytosis >12,000 cells/cubic mm or 10% immature forms.
definition source: https://www.galenreasoner.com/icd10codes/R65.9
has icd10 code: R65.0
has ICD10 name: Symptoms and signs specifically associated with systemic inflammation and infection.
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000457

epididymitis
type: Class
subclass of: symptoms specifically associated with systemic inflammation and infection
definition: is inflammation (swelling and irritation) of the epididymis, a tube at the back of the testicle that carries sperm
definition editor: Justin Song
definition source: https://my.clevelandclinic.org/health/diseases/17697-epididymitis#:~:text=Epididymitis%20is%20inflammation%20(swelling%20and,ages%20of%2014%20and%2035.
has icd10 code: R45.1
id: ICDO_0000458

localized edema
type: Class
subclass of: symptoms specifically associated with systemic inflammation and infection
definition: A disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R60-/R60.0
has icd10 code: R60.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000459

systemic inflammatory response syndrome of non-infectious origin
type: Class
subclass of: symptoms specifically associated with systemic inflammation and infection
definition: a serious condition related to systemic inflammation, organ dysfunction, and organ failure.
definition source: https://icd.codes/icd10cm/R651#:~:text=ICD%2D10%2DCM%20Code%20R65.,SIRS)%20of%20non%2Dinfectious%20origin
has icd10 code: R65.1
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000460

syncope and collapse
type: Class
subclass of: general symptoms
definition: fainting or passing out
definition: insufficient blood flow to the brain
definition source: https://www.heart.org/en/health-topics/arrhythmia/symptoms-diagnosis--monitoring-of-arrhythmia/syncope-fainting#:~:text=Syncope%20is%20a%20temporary%20loss,enough%20oxygen%20to%20the%20brain.
has icd10 code: R55
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000461

weakness
type: Class
subclass of: general symptoms
definition: decrease of strength in one or more muscles
definition source: https://www.medicinenet.com/weakness/symptoms.htm
has icd10 code: R53.1
has ICD10 name: weakness
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000462

sudden death, cause unknown
type: Class
subclass of: disease process
definition: Death occurring less than 24 hours from onset symptoms, not otherwise
definition source: https://medcode.ch/us/en/icds/ICD10-2016/R96
has icd10 code: R96.1
created by: Justin Song
creation date: 7/22/2020
id: ICDO_0000463

acidosis
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: A condition in which the blood is too acidic.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.2
has icd10 code: E87.2
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000464

diabetes mellitus without complications
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: blood sugar (glucose) levels are abnormally high because the body does not produce enough insulin to meet its needs.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.9#:~:text=Type%202%20diabetes%20mellitus%20without%20complications,-2016%202017%202018&text=9%20is%20a%20billable%2Fspecific,effective%20on%20October%201%2C%202019.
has icd10 code: E11.90
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000465

non-insulin-dependent diabetes mellitus with multiple complications
type: Class
subclass of: diabetes mellitus without complications
definition: combined defect of insulin serection and insulin resistance
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1336077/
has icd10 code: E11.7
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000466

disorder of lipoprotein metabolism, unspecified
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: disorders of lipoprotein metabolism that lead to atherosclerosis. These abnormalities arise from genetic and secondary factors and are caused by excessive entry of lipoproteins into the bloodstream or an impairment in their removal, or both.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E78-/E78.9
has icd10 code: E78.9
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000467

disorders of calcium metabolism
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: occur when the body has too little or too much calcium.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.5
has icd10 code: E83.5
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000468

hyperlipidemia, unspecified
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: Conditions with excess lipids in the blood.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E78-/E78.5
has icd10 code: E78.5
created by: Justin Song, Grace Whah
creation date: 7/25/2020
id: ICDO_0000469

hypo-osmolality and hyponatremia
type: Class
subclass of: disease processes of the blood stream
definition: A condition characterized by a dry, waxy type of swelling (edema) with abnormal deposits of mucopolysaccharides in the skin and other tissues. It is caused by a deficiency of thyroid hormones.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07/E03-/E03.9
has icd10 code: E87.1
created by: Justin Song, Virginia He
creation date: 7/23/2020
id: ICDO_0000470

hypokalemia
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
disjoint with: hypokalemia (unbillable)
definition: A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.6
has icd10 code: E87.6
code billability: Billable
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000471

hypokalemia (unbillable)
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.6
has icd10 code: E87.6
code billability: unbillable
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000472

hypothyroidism, unspecified
type: Class
subclass of: disorders of thyroid gland (NEW)
subclass of: disease processes of the blood stream
definition: A condition characterized by a dry, waxy type of swelling (edema) with abnormal deposits of mucopolysaccharides in the skin and other tissues. It is caused by a deficiency of thyroid hormones.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07/E03-/E03.9
has icd10 code: E03.9
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000473

mixed hyperlipidemia
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: A disorder of lipoprotein metabolism characterized by high levels of cholesterol and triglycerides in the blood. It is caused by elevation of low density and very low density lipoproteins.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E78-/E78.2
has icd10 code: E78.2
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000474

moderate protein-calorie malnutrition
type: Class
subclass of: malnutrition (NEW)
subclass of: disease processes of the blood stream
definition: an energy deficit due to chronic deficiency of all macronutrients
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E44-/E44.0
has icd10 code: E44.0
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000475

other specified hypothyroidism
type: Class
subclass of: disorders of thyroid gland (NEW)
subclass of: disease processes of the blood stream
definition: an underactive thyroid gland.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07/E03-/E03.8
has icd10 code: E03.8
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000476

overweight and obesity
type: Class
subclass of: overweight, obesity and other hyperalimentation (NEW)
subclass of: disease processes of the blood stream
definition: having more weight than the average human
definition editor: Justin Song, Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-
has icd10 code: E66
id: ICDO_0000477

morbid (severe) obesity due to excess calories
type: Class
subclass of: overweight, obesity and other hyperalimentation (NEW)
subclass of: overweight and obesity
definition: an abnormally high, unhealthy amount of body fat
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.01
has icd10 code: E66.01
created by: Justin Song, Grace Whah
creation date: 7/25/2020
id: ICDO_0000478

obesity due to excess calories
type: Class
subclass of: overweight, obesity and other hyperalimentation (NEW)
subclass of: overweight and obesity
definition: a condition marked by an abnormally high, unhealthy amount of body fat.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-#E66.0
has icd10 code: E66.0
created by: Justin Song, Grace Whah
creation date: 7/25/2020
id: ICDO_0000479

obesity, unspecified
type: Class
subclass of: overweight, obesity and other hyperalimentation (NEW)
subclass of: overweight and obesity
definition: A condition marked by an abnormally high, unhealthy amount of body fat.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.9
has icd10 code: E66.9
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000480

type 2 diabetes mellitus with circulatory complications
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not make or use insulin well.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.5
has icd10 code: E11.5
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000481

type 2 diabetes mellitus with diabetic chronic kidney disease
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: type 2 diabetes mellitus with kidney complications
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: a chronic medical condition in which sugar, or glucose, levels build up in your bloodstream. In type 2 diabetes, your body's cells aren't able to respond to insulin as well as they should.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.22
has icd10 code: E11.22
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000482

type 2 diabetes mellitus with hyperglycemia
type: Class
subclass of: diabetes mellitus (NEW)
subclass of: disease processes of the blood stream
definition: A chronic condition that affects the way the body processes blood sugar (glucose)
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.65
has icd10 code: E11.65
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000483

type 2 diabetes mellitus with kidney complications
type: Class
subclass of: disease processes of the blood stream
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: poorly controlled diabetes can lead to problems within the kidneys
definition source: https://www.mayoclinic.org/diseases-conditions/diabetic-nephropathy/symptoms-causes/syc-20354556#:~:text=Diabetic%20nephropathy%20is%20a%20common,and%20cause%20high%20blood%20pressure.
has icd10 code: E11.2
created by: Justin Song
creation date: 7/25/2020
id: ICDO_0000484

type 2 diabetes mellitus without complications
type: Class
subclass of: disease processes of the blood stream
definition: high levels of sugar in the blood
definition source: https://www.health.harvard.edu/a_to_z/type-2-diabetes-mellitus-a-to-z
has icd10 code: E11.9
created by: Justin Song
creation date: 7/25/2020
id: ICDO_0000485

unspecified severe protein-calorie malnutrition
type: Class
subclass of: malnutrition (NEW)
subclass of: disease processes of the blood stream
definition: an energy deficit due to chronic deficiency of all macronutrients
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E43-/E43
has icd10 code: E43
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000486

vitamin D deficiency, unspecified
type: Class
subclass of: other nutritional deficiencies (NEW)
subclass of: disease processes of the blood stream
definition: A nutritional condition produced by a deficiency of vitamin d in the diet, insufficient production of vitamin d in the skin, inadequate absorption of vitamin d from the diet, or abnormal conversion of vitamin d to its bioactive metabolites.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E55-/E55.9
has icd10 code: E55.9
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000487

volume depletion
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: Abnormally decreased volume of circulating fluid (plasma) in body.
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E86-/E86
has icd10 code: E86
created by: Justin Song, Virginia He, Grace Whah
creation date: 7/25/2020
id: ICDO_0000488

other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
type: Class
subclass of: disease (process) related to pregnancy
definition: symptoms during pregnancy and the puerperium (after the pregnancy)
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O94-O9A/O99-/O99.89
has icd10 code: O99.89
id: ICDO_0000489

other specified pregnancy related conditions, first trimester
type: Class
subclass of: other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
definition: symptoms that are related to being pregnant, pregnancy is in the first trimester
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.891
has icd10 code: O26.891
id: ICDO_0000490

herpes gestationis, first trimester
type: Class
subclass of: other specified pregnancy related conditions, first trimester
definition: a rare, itchy skin eruption that usually happens in the second or third trimester of pregnancy. It often begins with the appearance of very itchy red bumps or blisters on your abdomen and trunk, though it can show up on other parts of your body
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.41
has icd10 code: O26.41
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000491

low weight gain in pregnancy, first trimester
type: Class
subclass of: other specified pregnancy related conditions, first trimester
definition: when a mother gains weight during pregnancy
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.11
has icd10 code: O26.11
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000492

pregnancy related exhaustion and fatigue, first trimester
type: Class
subclass of: other specified pregnancy related conditions, first trimester
definition: when a mother becomes exhausted or fatigued during pregnancy
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.811
has icd10 code: O26.811
created by: Justin Song, Virginia He
id: ICDO_0000493

other specified pregnancy related conditions, second trimester
type: Class
subclass of: other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
definition: symptoms that are related to being pregnant, pregnancy is in the second trimester
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.892
has icd10 code: O26.892
id: ICDO_0000494

herpes gestationis, second trimester
type: Class
subclass of: other specified pregnancy related conditions, second trimester
definition: a rare, itchy skin eruption that usually happens in the second or third trimester of pregnancy. It often begins with the appearance of very itchy red bumps or blisters on your abdomen and trunk, though it can show up on other parts of your body
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.42
has icd10 code: O26.42
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000495

low weight gain in pregnancy, second trimester
type: Class
subclass of: other specified pregnancy related conditions, second trimester
definition: when a mother gains weight during pregnancy
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.12
has icd10 code: O26.12
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000496

pregnancy related exhaustion and fatigue, second trimester
type: Class
subclass of: other specified pregnancy related conditions, second trimester
definition: Fatigue caused from being pregnant, pregnancy is in the second trimester
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.812
has icd10 code: O26.812
id: ICDO_0000497

other specified pregnancy related conditions, third trimester
type: Class
subclass of: other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
definition: symptoms that are related to being pregnant, pregnancy is in the third trimester
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.893
has icd10 code: O26.893
id: ICDO_0000498

herpes gestationis, third trimester
type: Class
subclass of: other specified pregnancy related conditions, third trimester
definition: a rare, itchy skin eruption that usually happens in the second or third trimester of pregnancy. It often begins with the appearance of very itchy red bumps or blisters on your abdomen and trunk, though it can show up on other parts of your body
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.43
has icd10 code: O26.43
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000499

low weight gain in pregnancy, third trimester
type: Class
subclass of: other specified pregnancy related conditions, third trimester
definition: when a mother gains weight during pregnancy
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.13
has icd10 code: O26.13
created by: Justin Song, Virginia He
creation date: 7/25/2020
id: ICDO_0000500

pregnancy related exhaustion and fatigue, third trimester
type: Class
subclass of: other specified pregnancy related conditions, third trimester
definition: Fatigue caused from being pregnant, pregnancy is in the third trimester
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O26-/O26.813
has icd10 code: O26.813
id: ICDO_0000501

altered mental status, unspecified
type: Class
subclass of: mental disease processes
definition: general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, disorientation (not cognizant of self, time, or place), defects in judgment or thought, unusual or strange behavior, poor regulation of emotions, and disruptions in perception
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R41-/R41.82
has icd10 code: R41.82
id: ICDO_0000502

anorexia
type: Class
subclass of: altered mental status, unspecified
definition: emotional disorder that makes the patient try to lose weight
definition source: https://www.google.com/search
has icd10 code: R63.0
has ICD10 name: anorexia
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000503

dysphasia and aphasia
type: Class
subclass of: altered mental status, unspecified
definition: Aphasia is the term for full loss of language and dysphasia is the term for partial loss of language.
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R47-R49/R47-/R47.0
has icd10 code: R47.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000504

somnolence
type: Class
subclass of: altered mental status, unspecified
definition: a strong desire for sleep
definition source: https://en.wikipedia.org/wiki/Somnolence#:~:text=Somnolence%20(alternatively%20%22sleepiness%22%20or,long%20periods%20(compare%20hypersomnia).
has icd10 code: R40.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000505

mood disorder due to known physiological condition
type: Class
subclass of: mental disease processes
definition: effects a persons mental health and emotional state
definition editor: Justin Song
definition source: https://my.clevelandclinic.org/health/diseases/17843-mood-disorders#:~:text=A%20mood%20disorder%20is%20a,change%2C%20depending%20on%20the%20situation.
has icd10 code: F06.7
id: ICDO_0000506

alcohol dependence
type: Class
subclass of: mood disorder due to known physiological condition
definition: someone has drank alcohol so much, that they depend on it to function
definition editor: Justin Song
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860472/
has icd10 code: F10.2
id: ICDO_0000507

generalized anxiety disorder
type: Class
subclass of: mood disorder due to known physiological condition
definition: feelings of stress or fear that the patient cannot understand
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F41-/F41.1
has icd10 code: F41.1
id: ICDO_0000508

anxiety disorder, unspecified
type: Class
subclass of: generalized anxiety disorder
definition: A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F41-/F41.9
has icd10 code: F41.9
created by: Justin Song
id: ICDO_0000509

mixed anxiety and depressive disorder
type: Class
subclass of: generalized anxiety disorder
definition: feelings of severe despondency and dejection, a feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome
definition editor: Justin Song, Virginia He
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: F41.2
id: ICDO_0000510

major depressive disorder, single episode, unspecified
type: Class
subclass of: mood disorder due to known physiological condition
definition: A disorder characterized by melancholic feelings of grief or unhappiness.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.9
has icd10 code: F32.9
id: ICDO_0000511

nicotine dependence
type: Class
subclass of: mood disorder due to known physiological condition
definition: nicotine gives temprorary pleasure effects in your brain
definition editor: Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/nicotine-dependence/symptoms-causes/syc-20351584#:~:text=Nicotine%20dependence%20occurs%20when%20you,you%20need%20to%20feel%20good.
has icd10 code: F17.2
id: ICDO_0000512

unspecified dementia
type: Class
subclass of: mood disorder due to known physiological condition
definition: A condition in which a person loses the ability to think, remember, learn, make decisions, and solve problems. Symptoms may also include personality changes and emotional problems.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F03-/F03
has icd10 code: F03
id: ICDO_0000513

dementia in alzheimer's disease with late onset
type: Class
subclass of: unspecified dementia
definition: majority of diagnosed are above the age of 65, this disease is not treatable.
definition editor: Justin Song
definition source: https://www.alz.org/alzheimers-dementia/what-is-alzheimers
has icd10 code: F00.1
id: ICDO_0000514

allergy status to other drugs, medicaments and biological substances status
type: Class
subclass of: history
definition: a damaging immune response by the body to a substance, especially pollen, fur, a particular food, or dust, to which it has become hypersensitive.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z88-/Z88.8
has icd10 code: Z88.8
id: ICDO_0000515

allergy status to narcotic agent status
type: Class
subclass of: allergy status to other drugs, medicaments and biological substances status
definition: allergy to opiate agonist
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z88-/Z88.5
has icd10 code: Z88.5
id: ICDO_0000516

allergy status to penicillin
type: Class
subclass of: allergy status to other drugs, medicaments and biological substances status
definition: code is used to show the patient cannot be given penicillin
definition editor: Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/penicillin-allergy/symptoms-causes/syc-20376222
has icd10 code: Z88.0
id: ICDO_0000517

dependence on renal dialysis
type: Class
subclass of: history
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: patient is depending on renal dialysis which is a procedure that is a substitute for many of the normal functions of the kidneys
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z99-/Z99.2
has icd10 code: Z99.2
id: ICDO_0000518

dependence on respirator
type: Class
subclass of: history
definition: inability to breathe independently leading to dependence on respirator
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z99-/Z99.1
has icd10 code: Z99.1
id: ICDO_0000519

dependence on respirator [ventilator] status
type: Class
subclass of: dependence on respirator
definition: inability to breathe independently leading to dependence on respirator
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z99-/Z99.11
has icd10 code: Z99.11
id: ICDO_0000520

dependence on wheelchair
type: Class
subclass of: history
definition: dependence on wheelchair
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z99-/Z99.3
has icd10 code: Z99.3
id: ICDO_0000521

kidney transplant status
type: Class
subclass of: history
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: used to specify conditions like chronic kidey disease
definition editor: Justin Song
definition source: https://icdlist.com/icd-10/Z94.0
has icd10 code: Z94.0
id: ICDO_0000522

personal history of diseases of the circulatory system
type: Class
subclass of: history
definition: Interruptions, blockage, or diseases that affect how your heart or blood vessels pump blood can cause complications such as heart disease or stroke.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z86-/Z86.7
has icd10 code: Z86.7
id: ICDO_0000523

personal history of immunosupression therapy
type: Class
subclass of: history
definition: Treatment that lowers the activity of the body's immune system.
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.25
has icd10 code: Z92.2
id: ICDO_0000524

personal history of long-term (current) use of anticoagulants
type: Class
subclass of: history
definition: thinner blood
definition editor: Justin Song, Virginia He
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: Z92.1
id: ICDO_0000525

personal history of malignant neoplasm of breast
type: Class
subclass of: history
definition: malignant, aggressive tumor that forms in the breast
definition editor: Justin Song, Virginia He
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.3
has icd10 code: Z85.3
id: ICDO_0000526

personal history of malignant neoplasm of digestive organs
type: Class
subclass of: history
definition: tumors appear in the digestive system and stops functions
definition editor: Justin Song
definition source: https://en.wikipedia.org/wiki/Digestive_system_neoplasm#:~:text=Digestive%20system%20neoplasms%20are%20tumors,gastric%20cancer
has icd10 code: Z95.0
id: ICDO_0000527

personal history of medical treatment
type: Class
subclass of: history
definition: a history of medical treatment
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/Z92
has icd10 code: Z92.6
id: ICDO_0000528

personal history of nicotine dependence
type: Class
subclass of: history
definition: patient has had a history with nicotine. This information can be used to help pin down the exact disease
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z87-/Z87.891#:~:text=Personal%20history%20of%20nicotine%20dependence,-2016%202017%202018&text=Code%20POA%20Exempt-,Z87.,effective%20on%20October%201%2C%202019.
has icd10 code: Z87.891
id: ICDO_0000529

chronic cough
type: Class
subclass of: general symptoms
definition: A cough that lasts for at least eight weeks. Usually just a minor annoyance
definition source: www.mayoclinic.org
has icd10 code: R05
created by: Justin Song
id: ICDO_0000530

asphyxia and hypoxemia
type: Class
subclass of: lung disease processes due to external agents
definition: A condition due to lack of oxygen in respired air due to inhaling too much carbon monoxide
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R09-/R09.0
has icd10 code: R09.0
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000531

hypoxemia
type: Class
subclass of: lung disease processes due to external agents
definition: A condition in which there is not enough oxygen in the blood.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R09-/R09.02
has icd10 code: R09.02
code billability: Billable
id: ICDO_0000533

diarrhea, unspecified
type: Class
subclass of: general symptoms
definition: A condition of frequent and watery bowel movements. Causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R19-/R19.7
has icd10 code: R19.7
id: ICDO_0000534

disorientation, unspecified
type: Class
subclass of: general symptoms
definition: A disorder characterized by a lack of clear and orderly thought and behavior.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R41-/R41.0
has icd10 code: R41.0
id: ICDO_0000535

fever and other physiologic disturbances of temperature regulation
type: Class
subclass of: general signs
definition: A disorder characterized by elevation of the body's temperature above the upper limit of normal
definition editor: Justin Song
definition source: http://www.icd9data.com/2015/Volume1/780-799/780-789/780/780.6.htm
has icd10 code: Z80.6
id: ICDO_0000536

extrarenal uremia
type: Class
subclass of: general signs
subclass of: Restriction
  on property: occurs in
  some values from: kidney
definition: Uremia resulting not from primary renal disease but from disturbances in circulation, fluid balance, or metabolism arising in other parts of the body.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R30-R39/R39-/R39.2
has icd10 code: R39.2
id: ICDO_0000537

hyperkalemia
type: Class
subclass of: metabolic disorders (NEW)
subclass of: disease processes of the blood stream
definition: high blood potassium levels
definition editor: Justin Song, Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.5
has icd10 code: E87.5
id: ICDO_0000538

other specified abnormal findings of blood chemistry
type: Class
subclass of: general signs
definition: chemistry tests are used to diagnose many conditions and diseases
definition editor: Justin Song
definition source: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/blood-chemistry-test
has icd10 code: R79.89
id: ICDO_0000539

type 2 diabetes mellitus with unspecified complications
type: Class
subclass of: disease processes of the blood stream
definition: diabetes is usually an inherited disease that makes people obese and have problems with daily life
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/E118#:~:text=a%20principal%20diagnosis.-,E11.,to%20specify%20a%20medical%20diagnosis.
has icd10 code: E11.8
id: ICDO_0000540

dehydration
type: Class
subclass of: disease processes of the blood stream
definition: when a patient uses or loses more fluid than they take in
definition editor: Justin Song
definition source: https://www.mayoclinic.org/diseases-conditions/dehydration/symptoms-causes/syc-20354086#:~:text=Overview,fluids%2C%20you%20will%20get%20dehydrated.
has icd10 code: E86.0
id: ICDO_0000541

pure hypercholesterolemia
type: Class
subclass of: disease processes of the blood stream
definition: genetic anomaly that causes high cholesterol levels
definition editor: Justin Song
definition source: https://www.medicalnewstoday.com/articles/316173#complications
has icd10 code: E78.0
id: ICDO_0000542

supervision of other high-risk pregnancies
type: Class
subclass of: in contact with
definition: careful watch of patient who has a high chance of being pregnant
definition editor: Justin Song
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: Z35.8
id: ICDO_0000543

single live birth
type: Class
subclass of: supervision of other high-risk pregnancies
definition: used to just note the patient's status with their pregnancy
definition editor: Justin Song
definition source: https://icdlist.com/icd-10/Z37.0
has icd10 code: Z37.0
id: ICDO_0000544

type 2 diabetes mellitus with other specified complications
type: Class
subclass of: disease processes of the blood stream
definition: high blood sugar because body cannot break down the sugar being taken in
definition editor: Justin Song
definition source: https://icd.codes/icd10cm/E1169#:~:text=a%20principal%20diagnosis.-,E11.,to%20specify%20a%20medical%20diagnosis.
has icd10 code: E11.6
id: ICDO_0000545

difficulty in walking, not elsewhere classified
type: Class
subclass of: other abnormalities of gait and mobility
definition: patient is unable to walk due to an unspecified reason
definition editor: Justin Song
has icd10 code: R26.2
id: ICDO_0000546

hyperglycemia, unspecified
type: Class
subclass of: prediabetes
subclass of: disease processes of the blood stream
definition: Abnormally high blood glucose level, could be a sign of diabetes
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R70-R79/R73-/R73.9
has icd10 code: R73.9
created by: Justin Song
creation date: 7/23/2020
id: ICDO_0000547
label: type 2 diabetes mellitus with ketoacidosis

personal history of major surgery, not elsewhere classified
type: Class
subclass of: personal history of medical treatment
definition: this is a record of the patient
definition editor: Justin Song
definition source: http://www0.sun.ac.za/aotc/icd10/mf_icd10_codelist.php
has icd10 code: Z92.4
id: ICDO_0000548

other specified sepsis
type: Class
subclass of: disease processes of the blood stream
definition: a serious condition resulting from the presence of harmful microorganisms in the blood or other tissues and the body’s response to their presence, potentially leading to the malfunctioning of various organs, shock, and death.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A41-/A41.89
has icd10 code: A41.89
code billability: Billable
id: ICDO_0000549

myelodysplastic syndrome, unspecified
type: Class
subclass of: disease processes of the blood stream
definition: A disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/D37-D48/D46-/D46.9
has icd10 code: D46.9
code billability: Billable
id: ICDO_0000550

sickle-cell disease without crisis
type: Class
subclass of: disease processes of the blood stream
definition: A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D55-D59/D57-/D57.1
has icd10 code: D57.1
code billability: Billable
id: ICDO_0000551

mild protein-calorie malnutrition
type: Class
subclass of: malnutrition (NEW)
subclass of: disease processes of the blood stream
definition: body does not have enough nutrition to sustain itself
definition editor: Justin Song, Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E44-/E44.1
has icd10 code: E44.1
code billability: Billable
id: ICDO_0000552

iron deficiency
type: Class
subclass of: other nutritional deficiencies (NEW)
subclass of: disease processes of the blood stream
definition: iron deficiecy is due to insufficient iron
definition editor: Justin Song, Grace Whah
definition source: https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E61-/E61.1
has icd10 code: E61.1
code billability: Billable
id: ICDO_0000553

dementia in other diseases classified elsewhere
type: Class
subclass of: mood disorder due to known physiological condition
definition: this code must be sequenced as the second code, since it specifies that the disease has dementia in other diseases
definition editor: Justin Song
definition source: https://acdis.org/articles/qa-%E2%80%98code-first%E2%80%99-versus-%E2%80%98-diseases-classified-elsewhere%E2%80%99 https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F02-/F02.8
has icd10 code: F02.8
code billability: Non-Billable
id: ICDO_0000554

delirium due to known physiological condition
type: Class
subclass of: mood disorder due to known physiological condition
definition: An acutely disturbed state of mind that occurs in fever, intoxication, and other disorders and is characterized by restlessness, illusions, and incoherence of thought and speech
definition source: https://www.lexico.com/en/definition/delirium
has icd10 code: F05.0
code billability: Billable
id: ICDO_0000555

major depressive disorder, single episode, severe without psychotic features
type: Class
subclass of: mood disorder due to known physiological condition
definition: patients falls into depression, one episode
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.2
has icd10 code: F32.2
code billability: Billable
id: ICDO_0000556

insomnia
type: Class
subclass of: altered mental status, unspecified
definition: A disorder characterized by difficulty in falling asleep and/or remaining asleep.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.0
has icd10 code: G47.0
code billability: Non-Billable
id: ICDO_0000559

other pulmonary embolism without acute cor pulmonale
type: Class
subclass of: disease processes of the blood stream
definition: a sudden blockage in a lung artery. The cause is usually a blood clot in the leg called a deep vein thrombosis that breaks loose and travels through the bloodstream to the lung
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I26-I28/I26-/I26.99
has icd10 code: I26.99
code billability: Billable
id: ICDO_0000560

nonrheumatic aortic (valve) stenosis
type: Class
subclass of: disease processes of the blood stream
definition: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the aortic valve. It is characterized by restricted outflow from the left ventricle into the aorta.
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I35-/I35.0
has icd10 code: I35.0
code billability: Billable
id: ICDO_0000561

cardiac arrest
type: Class
subclass of: disease processes of the blood stream
definition: Cessation of heart beat or myocardial contraction. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation
definition editor: Justin Song
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I46-
has icd10 code: I46.0
code billability: Non-Billable
id: ICDO_0000562

disease processes of the blood stream
type: Class
subclass of: disease (process) of the circulatory system
created by: Justin Song

disease (process) related to pregnancy
type: Class
subclass of: disease process

mental disease processes
type: Class
subclass of: disease process

personal status and history
type: Class
subclass of: factors influencing health status and contact with health services
created by: Justin Song

New: disease
type: Class
subclass of: process
definition: A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not due to any immediate external injury.
definition editor: Jennifer Odalys Roman

laterality of anatomical entity
type: Class
subclass of: anatomical entity
definition: An anotomical entity that refers to the side of the body affected
definition editor: Ling Wan, Oliver He
alternative term: anatomical side
alternative term: laterality
definition source: http://provcomm.ibx.com/ProvComm/ProvComm.nsf/afe9b349fb4d82ef85257912006dc3f7/d72597970a1e0b49852579d1004b472c!OpenDocument

external ear canal eczema JYPM
type: Class
subclass of: external ear DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP output
  some values from: eczema entity
label: 外耳道湿疹 JYPM @zh

eczema entity
type: Class
subclass of: pathological anatomical entity
has_exact_synonym: 湿疹
label: 湿疹体 @zh

chronic external ear canal otitis JYPM
type: Class
subclass of: chronic otitis externa DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
subclass of: Restriction
  on property: has process profile
  some values from: chronic disease profile
label: 慢性外耳道炎 JYPM @zh

external ear canal abscess PKPM
type: Class
subclass of: abscess of external ear DP
subclass of: Restriction
  on property: occurs in
  some values from: external acoustic meatus
subclass of: Restriction
  on property: has DP output
  some values from: abscess
label: 外耳道脓肿 PKPM @zh

granuloma behind ear PKPM
type: Class
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: behind ear
subclass of: Restriction
  on property: has DP output
  some values from: granuloma
label: 耳后肉芽肿 PKPM @zh

behind ear
type: Class
subclass of: external ear
label: 耳后 @zh

pinna perichondritis PKPM
type: Class
subclass of: ear or mastoid disease process
subclass of: Restriction
  on property: occurs in
  some values from: pinna
subclass of: Restriction
  on property: has DP output
  some values from: perichondritis anatomical entity
label: 耳廓软骨膜炎 PKPM @zh

right side of anatomical entity
type: Class
subclass of: laterality of anatomical entity
definition editor: Ling Wan, Oliver He

left side of anatomical entity
type: Class
subclass of: laterality of anatomical entity
definition editor: Ling Wan, Oliver He

bilateral side of anatomical entity
type: Class
subclass of: laterality of anatomical entity
definition editor: Ling Wan, Oliver He

unspecified unilateral side of anatomical entity
type: Class
subclass of: laterality of anatomical entity
definition editor: Ling Wan, Oliver He
alternative term: Unilateral, unspecified

unspecified laterality of anatomical entity
type: Class
subclass of: laterality of anatomical entity
definition editor: Ling Wan, Oliver He

swimmer's ear LHEM
type: Class
subclass of: ear or mastoid disease process
label: 游泳者耳病 LHEM @zh

monoclonal gammopathy
type: Class
subclass of: disease processes of the blood stream
definition: A benign condition in which there is a higher-than-normal level of a protein called m protein in the blood.
definition editor: Grace Whah
has icd10 code: D47.2
code billability: Billable
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/D37-D48/D47-/D47.2

Etiology Entity
type: Class
subclass of: material entity
definition: the etiology entity is the reason or origination of disease process

Genetic Entity
type: Class
subclass of: Etiology Entity
label: 遗传因素 @zh

New: Other osteomyelitis
type: Class
subclass of: New: Other chronic osteomyelitis
definition: Inflammation of bone caused by infection, generally in the legs, arm, or spine.
definition editor: Jennifer Odalys Roman
definition source: https://my.clevelandclinic.org/health/diseases/9495-osteomyelitis#:~:text=Osteomyelitis%20is%20a%20bacterial%2C%20or,supply%20to%20the%20affected%20bone.
has icd10 code: M86.8
code billability: non-billable
anatomical location: bone spine
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M86-M90/M86-/M86.8
has_related_synonym: Bone infection
id: UBERON:0013706

Other forms of chronic ischemic heart disease
type: Class
subclass of: chronic ischemic heart DP
definition: Coronary artery disease (CAD) is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden coronary death.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I25-/I25.89
code billability: billable
anatomical location: coronary artery
source: https://icd.codes/icd10cm/I2589
id: UBERON:0001621

Pathological fracture, unspecified femur, sequela
type: Class
subclass of: New: disease
definition: a broken bone that's caused by a disease, rather than an injury.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/pathologic-fracture#:~:text=A%20pathologic%20fracture%20is%20a,been%20weakened%20by%20an%20illness.
has icd10 code: M84.453S
anatomical location: femur
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.4-/M84.453S

other unspecified acquired perforation of ear DP
type: Class
subclass of: Obsolete class

Chronic serous otitis media
type: Class
subclass of: other unspecified acquired perforation of ear DP
definition: When fluid remains in the middle ear, the condition is called chronic serous otitis media. Sometimes a middle ear infection causes a hole (perforation) in the eardrum. A hole that does not heal within six weeks
definition editor: Jennifer Odalys Roman
definition source: https://www.health.harvard.edu/a_to_z/chronic-otitis-media-cholesteatoma-and-mastoiditis-a-to-z
has icd10 code: H65.2
source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65.2

Chronic serous otitis media, unspecified ear
type: Class
subclass of: other unspecified acquired perforation of ear DP
definition: When fluid remains in the middle ear, the condition is called chronic serous otitis media. Sometimes a middle ear infection causes a hole (perforation) in the eardrum. A hole that does not heal within six weeks
definition editor: Jennifer Odalys Roman
alternative term: Chronic serous otitis media
definition source: https://www.health.harvard.edu/a_to_z/chronic-otitis-media-cholesteatoma-and-mastoiditis-a-to-z
has icd10 code: H65.20
source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65.20

Otalgia, unspecified ear
type: Class
subclass of: other specified infectious diseases of external ear DP
definition: Pain in the inner or outer ear that may interfere with ability to hear, often caused by excess fluid and infection.
definition editor: Jennifer Odalys Roman
alternative term: Ear pain
definition source: https://emedicine.medscape.com/article/845173-overview
has ICD10 name: H92.09
source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H90-H94/H92-/H92.09

Acute lymphoblastic leukemia, in relapse
type: Class
subclass of: acute disease profile
definition: Acute lymphoblastic leukemia is an acute form of leukemia, or cancer of the white blood cells, characterized by the overproduction and accumulation of cancerous, immature white blood cells, known as lymphoblasts.
definition editor: Jennifer Odalys Roman
alternative term: Acute lymphoid leukemia in relapse
has icd10 code: C91.02
source: https://icd.codes/icd10cm/C9102

Acute myeloblastic leukemia
type: Class
subclass of: acute disease profile
definition: Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia (ANLL), is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
definition editor: Jennifer Odalys Roman
alternative term: Acute myeloblastic leukemia, minimal differentiation
definition source: https://icd.codes/icd10cm/C920
has icd10 code: C92.0
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C92-/C92.0

Acute promyelocytic leukemia
type: Class
subclass of: acute disease profile
definition: Acute promyelocytic leukemia (APML, APL) is the M3 subtype of acute myelogenous leukemia (AML), a cancer of the white blood cells.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/C924
has icd10 code: C92.4
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C92-/C92.4

Pathological fracture, hip, unspecified, sequela
type: Class
subclass of: New: disease
definition: a broken bone that's caused by a disease, rather than an injury.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/pathologic-fracture#:~:text=A%20pathologic%20fracture%20is%20a,been%20weakened%20by%20an%20illness.
has icd10 code: M84.459S
anatomical location: hip
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.4-/M84.459S

Acute promyelocytic leukemia, not having achieved remission
type: Class
subclass of: Acute promyelocytic leukemia
definition: An acute myeloid leukemia (aml) in which abnormal promyelocytes predominate. It is characterized by the t(15;17)(q22;q12) translocation. There are two variants: the typical and microgranular variant. This aml is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis.
definition editor: Jennifer Odalys Roman
alternative term: Acute promyelocytic leukemia, fab m3
definition source: https://icd.codes/icd10cm/C924
has icd10 code: C92.40
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C92-/C92.40

Acute myeloblastic leukemia, not having achieved remission
type: Class
subclass of: Acute myeloblastic leukemia
definition: Acute myeloid leukemia (AML), also known as acute myelogenous leukemia or acute nonlymphocytic leukemia (ANLL), is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.
definition editor: Jennifer Odalys Roman
alternative term: Acute myelocytic leukemia w maturation
definition source: https://icd.codes/icd10cm/C920
has icd10 code: C92.00
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C92-/C92.00

Acute and subacute infective endocarditis
type: Class
subclass of: acute disease profile
definition: Subacute bacterial endocarditis is a type of endocarditis (more specifically, infective endocarditis). Subacute bacterial endocarditis can be considered a form of type III hypersensitivity.
definition editor: Jennifer Odalys Roman
alternative term: endocarditis lenta
definition source: https://en.wikipedia.org/wiki/Subacute_bacterial_endocarditis
has icd10 code: I33.0
source: https://icd.codes/icd10cm/I330

Acute and subacute endocarditis, unspecified
type: Class
subclass of: acute disease profile
definition: Infective endocarditis is a form of endocarditis. It is an inflammation of the inner tissues of the heart, the endocardium (such as its valves)
definition editor: Jennifer Odalys Roman
alternative term: Acute endocarditis
definition source: https://icd.codes/icd10cm/I339
has icd10 code: I33.9
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I33-/I33.9

Acute vascular disorders of intestine
type: Class
subclass of: acute disease profile
definition: omental infarction, or omental torsion, is an acute vascular disorder which compromises tissue of the greater omentum – the largest peritoneal fold in the abdomen.
definition editor: Jennifer Odalys Roman
alternative term: Acute ischemic colitis
definition source: https://en.wikipedia.org/wiki/Omental_infarction
has icd10 code: K55.0
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K55-/K55.0

Acute infarction of intestine, part unspecified
type: Class
subclass of: acute disease profile
definition: an irreversible injury to the intestine resulting from insufficient blood flow.
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Bowel_infarction#:~:text=Bowel%20infarction%20or%20gangrenous%20bowel,life%2Dthreatening%20infection%20and%20death.
has icd10 code: K55.06
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K55-/K55.06

Rheumatic disease profile
type: Class
subclass of: Rheumatic tricuspid insufficiency

Rheumatic aortic stenosis
type: Class
subclass of: Rheumatic disease profile

Rheumatic tricuspid valve diseases
type: Class
subclass of: Rheumatic disease profile

Rheumatic tricuspid stenosis
type: Class
subclass of: Rheumatic disease profile

Rheumatic tricuspid insufficiency
type: Class
subclass of: Rheumatic disease profile

Rheumatic tricuspid stenosis and insufficiency
type: Class
subclass of: Rheumatic disease profile

Other rheumatic tricuspid valve diseases
type: Class
subclass of: Rheumatic disease profile

Rheumatic tricuspid valve disease, unspecified
type: Class
subclass of: Rheumatic disease profile

Other nonrheumatic mitral valve disorders
type: Class
subclass of: Rheumatic disease profile

Pathological fracture, unspecified tibia and fibula, sequela
type: Class
subclass of: New: disease
definition: a broken bone that's caused by a disease, rather than an injury.
definition: https://www.healthline.com/health/pathologic-fracture#:~:text=A%20pathologic%20fracture%20is%20a,been%20weakened%20by%20an%20illness.
definition editor: Jennifer Odalys Roman
has icd10 code: M84.469S
anatomical location: fibula
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.4-/M84.469S

Pathological fracture in other disease, left foot, subsequent encounter for fracture with routine healing
type: Class
subclass of: New: disease
definition: a broken bone that's caused by a disease, rather than an injury.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/pathologic-fracture#:~:text=A%20pathologic%20fracture%20is%20a,been%20weakened%20by%20an%20illness.
has icd10 code: M84.675D
anatomical location: hairline fracture
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.6-/M84.675D

Remove mechanical kidney
type: Class
subclass of: kidney transplant status
definition editor: Jennifer Odalys Roman
definition source: https://www.hipaaspace.com/medical_billing/coding/icd-9/procedure/5598
has icd10 code: 5598

New: Chronic kidney disease, stage 1
type: Class
subclass of: dependence on renal dialysis
definition: Chronic kidney disease (CKD), also known as chronic renal disease, is progressive loss in kidney function over a period of months or years.
definition editor: Jennifer Odalys Roman
definition source: https://www.kidney.org/atoz/content/about-chronic-kidney-disease
has icd10 code: N18.1
anatomical location: kidney
source: https://icd.codes/icd10cm/N181

Renal failure following (induced) termination of pregnancy
type: Class
subclass of: dependence on renal dialysis
definition: Abortion is the ending of pregnancy by removing a fetus or embryo before it can survive outside the uterus. An abortion may be caused purposely and is then called an induced abortion, or less frequently, "induced miscarriage".
definition editor: Jennifer Odalys Roman
alternative term: Complete abortion complicated by renal failure
definition source: https://icd.codes/icd10cm/O0482
has icd10 code: O04.82
anatomical location: womb
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O00-O08/O04-/O04.82

Renal failure following ectopic and molar pregnancy
type: Class
subclass of: dependence on renal dialysis
definition: The biopsy findings were consistent with the renal lesions of toxemia of pregnancy, although other renal diseases such as Henoch Schonlein nephritis or lupus proliferative glomerulonephritis cannot be excluded
definition editor: Jennifer Odalys Roman
alternative term: Kidney failure (acute) following ectopic and molar pregnancy
definition source: https://pubmed.ncbi.nlm.nih.gov/7042259/
has icd10 code: O08.4
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O00-O08/O08-/O08.4

Osteonecrosis, unspecified
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Osteonecrosis occurs when your bones lose their blood supply. The bones die and eventually collapse, leading to pain and arthritis. You can have osteonecrosis in one or several bones. It is most common in the upper leg.
definition editor: Jennifer Odalys Roman
definition source: https://www.niams.nih.gov/health-topics/osteonecrosis
has icd10 code: M87.9
anatomical location: billable
anatomical location: upper arm bone
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M86-M90/M87-/M87.9
has_related_synonym: Bone necrosis
id: UBERON:0004250

Pneumonia, unspecified organism
type: Class
subclass of: influenza due to pathogen
definition: Bronchopneumonia, bronchial pneumonia or bronchogenic pneumonia (not to be confused with lobar pneumonia) is the acute inflammation of the walls of the bronchioles.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J18-/J18
has icd10 code: J18
code billability: Non-Billable
anatomical location: lung
source: https://icd.codes/icd10cm/J18
id: UBERON:0002048

Influenza due to other identified influenza virus with other respiratory manifestations
type: Class
subclass of: influenza due to pathogen
definition: Respiratory disease is a medical term that encompasses pathological conditions affecting the organs and tissues that make gas exchange possible in higher organisms, and includes conditions of the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J101
has icd10 code: J10.1
code billability: billable
anatomical location: upper respiratory tract
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J10-/J10.1
has_related_synonym: Influenza due to influenza a virus subtype h1n1
id: UBERON:0001557

Influenza due to unidentified influenza virus with gastrointestinal manifestations
type: Class
subclass of: influenza due to pathogen
definition: Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J112
has icd10 code: J11.2
code billability: billable
anatomical location: lumen of gastrointestinal system
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.2
has_related_synonym: Gastroenteritis due to influenza
id: UBERON:0011565

Influenza due to unidentified influenza virus with encephalopathy
type: Class
subclass of: influenza due to pathogen
definition: Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract that involves the stomach and small intestine.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J1181
has icd10 code: J11.81
code billability: billable
anatomical location: gastrointestinal peritoneum
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.81
has_related_synonym: Influenza with encephalopathy
id: UBERON:3010819

Influenza due to unidentified influenza virus with other manifestations
type: Class
subclass of: influenza due to pathogen
definition: Gastroenteritis, also known as infectious diarrhea, is inflammation of the gastrointestinal tract that involves the stomach and small intestine.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J1189
has icd10 code: J11.89
code billability: billable
anatomical location: upper respiratory tract
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.89
id: UBERON:0001557

Other specified interstitial pulmonary diseases
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition editor: Jennifer Odalys Roman
has icd10 code: J84.8
code billability: non-billable
anatomical location: UBERON:0002048
anatomical location: lung

Bronchitis, not specified as acute or chronic
type: Class
subclass of: chronic lower respiratory diseases
definition: Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by chronically poor airflow.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J40
has icd10 code: J40
code billability: billable
anatomical location: bronchial tube
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J40-/J40
has_exact_synonym: Bronchitis
id: UBERON:3010524

Simple chronic bronchitis
type: Class
subclass of: chronic lower respiratory diseases
definition: Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by chronically poor airflow.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/J410
has icd10 code: J41.0
code billability: billable
anatomical location: bronchiole
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J41-/J41.0
has_related_synonym: Chronic bronchitis, simple
id: UBERON:0002186

Unspecified asthma with (acute) exacerbation
type: Class
subclass of: chronic lower respiratory diseases
definition: Asthma is a common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction and bronchospasm.
definition editor: Jennifer Odalys Roman
definition source: J45.901
definition source: https://icd.codes/icd10cm/J45901
code billability: billable
anatomical location: UBERON:0002185
anatomical location: bronchus
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J45-/J45.901
has_related_synonym: bronchial asthma

Pulmonary collapse
type: Class
subclass of: other diseases of the respiratory system
definition: the collapse or closure of a lung resulting in reduced or absent gas exchange.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.1
has icd10 code: J98.1
code billability: non-billable
anatomical location: lung
source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.1
id: UBERON:0002048

Osteolysis, left ankle and foot
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Osteolysis is an active resorption of bone matrix by osteoclasts during the natural formation of healthy bones
definition editor: Jennifer Odalys Roman
definition source: https://books.google.com/books
has icd10 code: M89.572
code billability: billable
anatomical location: pes bone
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M86-M90/M89-/M89.572
has_related_synonym: Osteolysis of left ankle and foot
id: UBERON:0005899

Angina pectoris, unspecified
type: Class
subclass of: ischemic heart DP
definition: Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden coronary death. It is within the group of cardiovascular diseases of which it is the most common type.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/I209
has icd10 code: I20.9
code billability: Billable
anatomical location: heart
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I20-/I20.9
has_related_synonym: Cardiac syndrome x
id: UBERON:0000948

ST elevation (STEMI) myocardial infarction of anterior wall
type: Class
subclass of: ischemic heart DP
definition: Unstable angina (UA) is a type of angina pectoris that is irregular.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/I210
has icd10 code: I21.0
code billability: Non-Billable
anatomical location: heart
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I21-/I21.0
id: UBERON:0000948

Atrioventricular block, first degree
type: Class
subclass of: atrioventricular and left bundle-branch block DP
definition: First-degree atrioventricular block (AV block), or PR prolongation, is a disease of the electrical conduction system of the heart in which the PR interval is lengthened beyond 0.20 seconds.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/I440
has icd10 code: I44.0
code billability: Billable
anatomical location: heart
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I44-/I44.0
has_related_synonym: First degree atrioventricular block
id: UBERON:0000948

Other secondary pulmonary hypertension
type: Class
subclass of: pulmonary heart DP and disease processes of pulmonary circulation
definition: Pulmonary hypertension (PH) is an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, leg swelling and other symptoms.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/I272
has icd10 code: I27.2
code billability: billable
anatomical location: artery
source: https://www.icd10data.com/ICD10CM/Codes/I00-I99/I26-I28/I27-/I27.2
has_related_synonym: Pulmonary arterial hypertension
id: UBERON:0001637

Crohn's disease, unspecified
type: Class
subclass of: disease (process) of the digestive system
definition: Enteritis (entero- + -itis) is inflammation of the small intestine.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/K509
has icd10 code: K50.9
code billability: Non-Billable
anatomical location: intestine
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52/K50-/K50.9
has_related_synonym: ileitis
id: UBERON:0000160

Other impaction of intestine
type: Class
subclass of: disease (process) of the digestive system
definition: An enterolith is a mineral concretion or calculus formed anywhere in the gastrointestinal system.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/K564
has icd10 code: K56.4
code billability: non-Billable
anatomical location: intestine
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K56-/K56.4
id: UBERON:0000160

Diaphragmatic hernia without obstruction or gangrene
type: Class
subclass of: disease (process) of the digestive system
definition: A congenital or acquired weakness or opening in the diaphragm which allows abdominal contents to protrude into the chest cavity; congenital diaphragmatic hernias are caused when the embryonic diaphragm fails to fuse.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46/K44-/K44.9
has icd10 code: K44.9
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46/K44-/K44.9

Oral mucositis (ulcerative), unspecified
type: Class
subclass of: disease (process) of the digestive system
definition: A mouth ulcer (also termed an oral ulcer, or a mucosal ulcer) is an ulcer that occurs on the mucous membrane of the oral cavity.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/K1230
has icd10 code: K12.30
code billability: billable
anatomical location: mouth mucosa
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K00-K14/K12-/K12.30
has_exact_synonym: Oral mucositis
id: UBERON:0003729

Unspecified acute appendicitis
type: Class
subclass of: disease (process) of the digestive system
definition: A disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.
definition editor: Jennifer Odalys Roman
has icd10 code: K35.80
code billability: billable
anatomical location: vermiform appendix
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K35-K38/K35-/K35.80
id: UBERON:0001154

Unspecified appendicitis
type: Class
subclass of: disease (process) of the digestive system
definition: Acute inflammation of the appendix. Acute appendicitis is classified as simple, gangrenous, or perforated.
definition editor: Jennifer Odalys Roman
has icd10 code: K37
code billability: billable
anatomical location: crypt of Lieberkuhn of appendix
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K35-K38/K37-/K37
has_related_synonym: Appendicitis
id: UBERON:0013486

Unilateral femoral hernia, with obstruction, without gangrene, not specified as recurrent
type: Class
subclass of: disease (process) of the digestive system
definition: A hernia is caused by the protrusion of a viscus (in the case of groin hernias, an intraabdominal organ) through a weakness in the containing wall.
definition editor: Jennifer Odalys Roman
has icd10 code: K41.30
code billability: billable
anatomical location: hindlimb stylopod muscle
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46/K41-/K41.30
has_related_synonym: Femoral hernia, unilateral with obstruction
id: UBERON:0004252

Unspecified abdominal hernia with obstruction, without gangrene
type: Class
subclass of: disease (process) of the digestive system
definition: a hernia is the exit of an organ, such as the bowel, through the wall of the cavity in which it normally resides.
definition editor: Jennifer Odalys Roman
has icd10 code: K46.0
code billability: billable
anatomical location: anterior abdominal wall muscle
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46/K46-/K46.0
has_related_synonym: Abdominal hernia with obstruction
id: UBERON:0002461

New: Ulcerative (chronic) pancolitis
type: Class
subclass of: disease (process) of the digestive system
definition: Enterocolitis or coloenteritis is an inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon.
definition editor: Jennifer Odalys Roman
has icd10 code: K51.0
code billability: digestive tract
code billability: non-billable
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52/K51-/K51.0
id: UBERON:0001555

New: Other ulcerative colitis without complications
type: Class
subclass of: New: Ulcerative (chronic) pancolitis
definition: A chronic, inflammatory bowel disease that causes inflammation in the digestive tract.
definition: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52/K51-/K51.80
definition editor: Jennifer Odalys Roman
has icd10 code: K51.80
code billability: billable
anatomical location: digestive tract
has_related_synonym: Eosinophilic ulcerative colitis
id: UBERON:0001555

Obstruction of gallbladder
type: Class
subclass of: disease (process) of the digestive system
definition: A biliary obstruction is a blockage of the bile ducts.
definition editor: Jennifer Odalys Roman
has icd10 code: K82.0
code billability: billable
anatomical location: bile duct
source: https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87/K82-/K82.0
id: UBERON:0002394

New: Hereditary choroidal dystrophy
type: Class
subclass of: disease (process) of the eye and adnexa
definition: an eye disorder that involves a layer of blood vessels called the choroid.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/H312
has icd10 code: H31.2
code billability: non-billable
anatomical location: optic choroid
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H30-H36/H31-/H31.2
id: UBERON:0001776

New: Hereditary choroidal dystrophy, unspecified
type: Class
subclass of: New: Hereditary choroidal dystrophy
definition: an eye disorder that involves a layer of blood vessels called the choroid.
definition source: https://icd.codes/icd10cm/H3120
has icd10 code: H31.20
code billability: billable
anatomical location: optic choroid
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H30-H36/H31-/H31.20
id: UBERON:0001776

Other retinal disorders
type: Class
subclass of: degeneration of macula and posterior pole
definition: affect this vital tissue. They can affect your vision, and some can be serious enough to cause blindness.
definition editor: Jennifer Odalys Roman
definition source: https://medlineplus.gov/retinaldisorders.html#:~:text=Retinal%20disorders%20affect%20this%20vital,Diabetic%20eye%20disease
has icd10 code: H35
code billability: non-billable
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H30-H36/H35-/H35

Disorders of visual cortex
type: Class
subclass of: disease (process) of the eye and adnexa
definition: a decreased ability to see to a degree that causes problems not fixable by usual means, such as glasses.
definition editor: Jennifer Odalys Roman
has icd10 code: H47.6
anatomical location: visual cortex
source: https://www.icd10data.com/ICD10CM/Codes/H00-H59/H46-H47/H47-/H47.6
has_related_synonym: vision impairment or vision loss
id: UBERON:0000411

New: Chronic kidney disease, stage 2 (mild)
type: Class
subclass of: chronic kidney disease DP
definition: progressive loss in kidney function over a period of months or years.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/N182
has icd10 code: N18.2
code billability: Billable
anatomical location: kidney
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.2
has_exact_synonym: Chronic kidney disease stage 2
id: UBERON:0002113

Nonobstructive reflux-associated chronic pyelonephritis
type: Class
subclass of: renal tubulo-interstitial disease processes
definition: Reflux nephropathy is kidney damage (nephropathy) due to urine flowing backward (reflux) from the bladder toward the kidneys; the latter is called vesicoureteral reflux (VUR).
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Reflux_nephropathy
has icd10 code: N11.0
code billability: billable
anatomical location: kidney
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N11-/N11.0
id: UBERON:0002113

Acute nephritic syndrome with other morphologic changes
type: Class
subclass of: disease (process) of the genitourinary system
definition: Acute proliferative glomerulonephritis is a disorder of the glomeruli (glomerulonephritis), or small blood vessels in the kidneys.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/N008
has icd10 code: N00.8
code billability: billable
anatomical location: kidney
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N00-N08/N00-/N00.8
has_related_synonym: Acute proliferative glomerulonephritis
id: UBERON:0002113

Unspecified nephritic syndrome with unspecified morphologic changes
type: Class
subclass of: disease (process) of the genitourinary system
definition: a kidney disorder that causes your body to pass too much protein in your urine
definition editor: Jennifer Odalys Roman
definition source: https://ada.com/conditions/nephritic-syndrome/
has icd10 code: N05.9
code billability: billable
anatomical location: UBERON:0001981 UBERON:0002113
anatomical location: blood vessel kidney
source: https://icd.codes/icd10cm/N059

New: Calculus of ureter
type: Class
subclass of: disease (process) of the genitourinary system
definition: Ureteral stones are kidney stones that have become stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder)
definition editor: Jennifer Odalys Roman
definition source: https://my.clevelandclinic.org/health/diseases/16514-ureteral-stones#:~:text=Ureteral%20stones%20are%20kidney%20stones%20that%20have%20become%20stuck%20in,blockage%20can%20cause%20severe%20pain.
has icd10 code: N20.1
code billability: billable
anatomical location: urothelium
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N20-N23/N20-/N20.1
has_related_synonym: ureter stones
id: UBERON:0000365

Nephrogenic diabetes insipidus
type: Class
subclass of: disease (process) of the genitourinary system
definition: A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and hypokalemia. ~ an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine.
definition editor: Jennifer Odalys Roman
definition source: https://www.merckmanuals.com/professional/genitourinary-disorders/renal-transport-abnormalities/nephrogenic-diabetes-insipidus#:~:text=Nephrogenic%20diabetes%20insipidus%20(NDI)%20is,that%20impair%20renal%20concentrating%20ability.
has icd10 code: N25.1
code billability: billable
anatomical location: renal tubule
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N30-N39/N30-/N30.0
id: UBERON:0009773

New: Acute cystitis
type: Class
subclass of: disease (process) of the genitourinary system
definition: An acute infection of the bladder
definition editor: Jennifer Odalys Roman
has icd10 code: N30.0
code billability: non-billable
anatomical location: urinary bladder
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N30-N39/N30-/N30.0
has_related_synonym: Urinary bladder disease
id: UBERON:0001255

New: Acute cystitis without hematuria
type: Class
subclass of: New: Acute cystitis
definition: a sudden inflammation of the urinary bladder
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/cystitis-acute#:~:text=Acute%20cystitis%20is%20a%20sudden,can%20also%20cause%20acute%20cystitis.
has icd10 code: N30.00
code billability: billable
anatomical location: urinary bladder
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N30-N39/N30-/N30.00
has_related_synonym: urinary tract infection (UTI)
id: UBERON:0001255

New: Acute cystitis with hematuria
type: Class
subclass of: New: Acute cystitis
definition: sudden onset of hematuria combined with bladder pain and irritative bladder symptoms. Hematuria is blood in the urine.
definition editor: Jennifer Odalys Roman
definition source: http://chemocare.com/chemotherapy/side-effects/hemorrhagic-cystitis.aspx#:~:text=Hemorrhagic%20cystitis%20is%20the%20sudden,variety%20of%20causes%20of%20hematuria.
has icd10 code: N30.01
code billability: billable
anatomical location: urinary bladder
source: https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53/N40-/N40.0
id: UBERON:0001255

Benign prostatic hyperplasia without lower urinary tract symptoms
type: Class
subclass of: benign prostatic hyperplasia DP
definition: Age-associated prostate gland enlargement that can cause urination difficulty.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/benign-prostatic-hyperplasia/symptoms-causes/syc-20370087#:~:text=Benign%20prostatic%20hyperplasia%20(BPH)%20%E2%80%94,urinary%20tract%20or%20kidney%20problems.
has icd10 code: N40.0
code billability: billable
code billability: prostate gland enlargement
anatomical location: prostate gland
source: https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O00-O08/O04-/O04.82
id: UBERON:0002367

Osteoarthritis of knee, unspecified
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and underlying bone.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/M179
has icd10 code: M17.9
code billability: Billable
anatomical location: UBERON:0000982
anatomical location: skeletal joint
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M15-M19/M17-/M17.9
has_related_synonym: Arthritis of left/right knee

New: Ankylosing spondylitis
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Spondyloarthropathy or spondyloarthrosis refers to any joint disease of the vertebral column.
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Spondyloarthropathy#:~:text=Specialty,disease%20of%20the%20vertebra%20itself.
has icd10 code: M45
code billability: non-billable
anatomical location: spine
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M45-M49/M45-/M45
has_related_synonym: Bechterew's disease
id: UBERON:0013706

New: Juvenile rheumatoid polyarthritis (seronegative)
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Childhood arthritis is any form of arthritis or arthritis-related conditions which affects individuals under the age of 16.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/juvenile-idiopathic-arthritis/symptoms-causes/syc-20374082#:~:text=Juvenile%20idiopathic%20arthritis%2C%20formerly%20known,joint%20pain%2C%20swelling%20and%20stiffness.
has icd10 code: M08.3
code billability: billable
anatomical location: immune system
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M08-/M08.3
has_related_synonym: juvenile arthritis (JA)
id: UBERON:0002405

New: Juvenile arthritis, unspecified, unspecified site
type: Class
subclass of: New: Juvenile rheumatoid polyarthritis (seronegative)
definition: Childhood arthritis is any form of arthritis or arthritis-related conditions which affects individuals under the age of 16
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/juvenile-idiopathic-arthritis/symptoms-causes/syc-20374082#:~:text=Juvenile%20idiopathic%20arthritis%2C%20formerly%20known,joint%20pain%2C%20swelling%20and%20stiffness.
has icd10 code: M08.90
code billability: billable
anatomical location: immune system
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M08-/M08.90
has_related_synonym: juvenile arthritis (JA)
id: UBERON:0002405

Other specified systemic involvement of connective tissue
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: Toxic oil syndrome is a musculoskeletal disease most famous for a 1981 outbreak in Spain which killed over 600 people and was likely caused by contaminated colza oil.
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Toxic_oil_syndrome
has icd10 code: M35.8
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M30-M36/M35-/M35.8
has_related_synonym: musculoskeletal system
has_related_synonym: toxic syndrome
id: UBERON:0002204

New: Infective myositis
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: A disorder characterized by an infectious process involving the skeletal muscles.
definition editor: Jennifer Odalys Roman
has icd10 code: M60.0
code billability: non-billable
anatomical location: skeletal muscle organ
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M60-M63/M60-/M60.0
id: UBERON:0014892

New: Infective myositis, unspecified site
type: Class
subclass of: New: Infective myositis
definition: bacterial infection of the skeletal muscles which results in a pus-filled abscess.
definition editor: Jennifer Odalys Roman
definition source: https://www.sciencedirect.com/topics/immunology-and-microbiology/pyomyositis#:~:text=Pyomyositis%20is%20a%20pyogenic%20infection,contained%20by%20hypervascular%20connective%20tissue.
has icd10 code: M60.00
code billability: non-billable
anatomical location: skeletal muscle organ
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M60-M63/M60-/M60.00
id: UBERON:0014892

Osteitis deformans in neoplastic diseases, unspecified site
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: A chronic condition in which both the breakdown and regrowth of bone are increased.
definition editor: Jennifer Odalys Roman
alternative term: Paget's disease
definition source: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/paget-disease-of-bone
has icd10 code: M90.60
code billability: billable
anatomical location: leg bone
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M86-M90/M90-/M90.60
id: UBERON:0005893

New: Stress fracture, unspecified tibia and fibula, sequela
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: a fatigue-induced fracture of the bone caused by repeated stress over time.
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658382/#:~:text=A%20stress%20fracture%20is%20a,applications%20of%20stress%20over%20time.
has icd10 code: M84.369S
anatomical location: billable
anatomical location: skeletal muscle organ
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.3-/M84.369S
has_related_synonym: hairline fracture
id: UBERON:0014892

New: Stress fracture, unspecified foot, sequela
type: Class
subclass of: New: Stress fracture, unspecified tibia and fibula, sequela
definition: a fatigue-induced fracture of the bone caused by repeated stress over time.
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658382/#:~:text=A%20stress%20fracture%20is%20a,applications%20of%20stress%20over%20time.
has icd10 code: M84.376S
code billability: billable
anatomical location: skeletal muscle organ
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M80-M85/M84/M84.3-/M84.376S
has_related_synonym: hairline fracture
id: UBERON:0014892

New: Other chronic osteomyelitis
type: Class
subclass of: disease (process) of the musculoskeletal system and connective tissue
definition: infection and inflammation of the bone or bone marrow
definition editor: Jennifer Odalys Roman
definition source: https://www.medicalnewstoday.com/articles/178819#:~:text=Osteomyelitis%20is%20an%20infection%20and,due%20to%20injury%20or%20surgery.
has icd10 code: M86.6
code billability: non-billable
anatomical location: bone marrow
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M86-M90/M86-/M86.6
has_related_synonym: OM
id: UBERON:0002371

Flaccid hemiplegia
type: Class
subclass of: disease (process) of the nervous system
definition: Flaccid paralysis is a clinical manifestation characterized by weakness or paralysis and reduced muscle tone without other obvious cause (e.g., trauma).
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Flaccid_paralysis
has icd10 code: G81.0
code billability: non-billable
anatomical location: brain
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.0
id: UBERON:0000955

Epilepsy, unspecified, not intractable, without status epilepticus
type: Class
subclass of: epilepsy, unspecified
definition: If you have epilepsy, you may have seizures repeatedly. A seizure that lasts longer than 5 minutes, or having more than 1 seizure within a 5 minutes period, without returning to a normal level of consciousness between episodes
definition editor: Jennifer Odalys Roman
definition source: https://www.hopkinsmedicine.org/health/conditions-and-diseases/status-epilepticus#:~:text=A%20seizure%20that%20lasts%20longer,episodes%20is%20called%20status%20epilepticus.
has icd10 code: G40.909
code billability: billable
anatomical location: UBERON:0000955
anatomical location: brain
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.909
has_related_synonym: seizure disorder

New: araplegia
type: Class
subclass of: disease (process) of the nervous system
definition: A slight paralysis or weakness of both legs.
definition editor: Jennifer Odalys Roman
definition source: https://www.medicalnewstoday.com/articles/paralysis#:~:text=Types%20of%20paralysis%20include%3A,organs%20in%20the%20lower%20abdomen.
has icd10 code: G82.2
code billability: non-billable
anatomical location: pelvic region of trunk
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G82-/G82.2
has_related_synonym: leg paralysis
id: UBERON:0002355

New: Paraplegia, unspecified
type: Class
subclass of: New: araplegia
definition: A slight paralysis or weakness of both legs.
definition editor: Jennifer Odalys Roman
definition source: https://www.medicalnewstoday.com/articles/paralysis#:~:text=Types%20of%20paralysis%20include%3A,organs%20in%20the%20lower%20abdomen.
has icd10 code: G82.20
code billability: billable
anatomical location: pelvic region of trunk
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G82-/G82.20
has_related_synonym: leg paralysis
id: UBERON:0002355

Paralytic syndrome, unspecified
type: Class
subclass of: disease (process) of the nervous system
definition: symmetric, ascending weakness that progresses over days and is associated with normal sensation, with often preserved tendon reflexes, and with an increased cerebrospinal fluid protein concentration.
definition editor: Jennifer Odalys Roman
definition source: https://www.sciencedirect.com/topics/neuroscience/paralytic-syndrome#:~:text=Acute%20Motor%20Axonal%20Neuropathy,increased%20cerebrospinal%20fluid%20protein%20concentration.
has icd10 code: G83.9
code billability: billable
anatomical location: brain
source: https://icd.codes/icd10cm/G839
has_related_synonym: Paralysis
id: UBERON:0000955

New: Communicating hydrocephalus
type: Class
subclass of: disease (process) of the nervous system
definition: inadequate reabsorption of CSF
definition editor: Jennifer Odalys Roman
definition source: https://onlinelibrary.wiley.com/doi/full/10.1002/9780470015902.a0002191.pub2
has icd10 code: G91.0
code billability: billable
anatomical location: cerebrospinal fluid
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G91-/G91.0
has_related_synonym: Hydrocephalus, communicating
id: UBERON:0001359

New: Hydrocephalus, unspecified
type: Class
subclass of: New: Communicating hydrocephalus
definition: a rare medical condition in which there is an abnormal accumulation of cerebrospinal fluid (CSF) in the brain.
definition editor: Jennifer Odalys Roman
definition source: https://www.hopkinsmedicine.org/health/conditions-and-diseases/hydrocephalus#:~:text=Hydrocephalus%20is%20a%20condition%20characterized,the%20brain%20and%20spinal%20cord.
has icd10 code: G91.9
code billability: billable
anatomical location: cerebrospinal fluid
source: https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G91-/G91.9
has_related_synonym: Acquired hydrocephalus
id: UBERON:0001359

Contact with and (suspected) exposure to intestinal infectious diseases
type: Class
subclass of: contact with and (suspected) exposure to other communicable diseases
definition: large number of infections of the bowels including: cholera, typhoid fever, paratyphoid fever, other types of salmonella infections, shigellosis, botulism, gastroenteritis, and amoebiasis among others.
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Intestinal_infectious_diseases#:~:text=Intestinal%20infectious%20diseases%20include%20a,gastroenteritis%2C%20and%20amoebiasis%20among%20others.
has icd10 code: Z20.0
code billability: non-billable
anatomical location: body proper
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z20-/Z20.0
id: UBERON:0013702

Encounter for care and examination of lactating mother
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition editor: Jennifer Odalys Roman
has icd10 code: Z39.1
anatomical location: abdomen
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z30-Z39/Z39-/Z39.1
has_related_synonym: Encounter for supervision of lactation
id: UBERON:0000916

Encounter for attention to dressings, sutures and drains
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition editor: Jennifer Odalys Roman
has icd10 code: Z48.0
has icd10 code: non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z48-/Z48.0

Encounter for other specified postprocedural aftercare
type: Class
subclass of: Encounter for attention to dressings, sutures and drains
definition: Aftercare visit codes cover situations occurring when the initial treatment of a disease has been performed and the patient requires continued care during the healing or recovery phase, or care for the long-term consequences of the disease
definition editor: Jennifer Odalys Roman
has icd10 code: Z48.8
code billability: non-billable
anatomical location: body proper
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z48-/Z48.8
id: UBERON:0013702

Other problems related to social environment
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition editor: Jennifer Odalys Roman
has icd10 code: Z60.8
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z60-/Z60.8
has_related_synonym: Peer problem

Problem related to primary support group, unspecified
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition editor: Jennifer Odalys Roman
has icd10 code: Z63.9
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z63-/Z63.9

New: Acquired absence of lung [part of]
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition editor: Jennifer Odalys Roman
has icd10 code: Z90.2
code billability: billable
anatomical location: lung
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z90-/Z90.2
id: UBERON:0002048

Carrier of other infectious diseases
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: a person or other organism that has become infected with a pathogen, but that displays no signs or symptoms. Although unaffected by the pathogen, carriers can transmit it to others or develop symptoms in later stages of the disease.
definition editor: Jennifer Odalys Roman
definition source: https://en.wikipedia.org/wiki/Asymptomatic_carrier#:~:text=An%20asymptomatic%20carrier%20is%20a,later%20stages%20of%20the%20disease.
has icd10 code: Z22.8
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z22-/Z22.8

Encounter for fitting and adjustment of non-vascular catheter
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: complication inserting a temporary long, flexible, y-shaped tube that is inserted through one of the central veins found in your neck, chest or groin to allow access to the bloodstream
definition editor: Jennifer Odalys Roman
definition source: https://www.azuravascularcare.com/infodialysisaccess/difference-between-cvc-and-picc/
has icd10 code: Z46.82
code billability: billable
anatomical location: internal jugular vein
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z46-/Z46.82
id: UBERON:0001586

Body mass index [BMI] 38.0-38.9, adult
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: places one among the people considered obese, but also fall in the higher end of this category, meaning that gaining even more weight would put one in the danger of classifying as extremely obese
definition editor: Jennifer Odalys Roman
definition source: https://www.marinahospital.com/weight-loss/bmi/38
has icd10 code: Z68.38
code billability: billable
anatomical location: subcutaneous adipose tissue
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z68-Z68/Z68-/Z68.38
has_related_synonym: Adult body mass index 38-38.9 - obesity
id: UBERON:0002190

Personal history of malignant neoplasm of stomach
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: Cancer that occurs in the stomach.
definition editor: Jennifer Odalys Roman
alternative term: Stomach cancer
definition source: https://www.cancer.org/cancer/stomach-cancer/about/what-is-stomach-cancer.html
has icd10 code: Z85.02
code billability: non-billable
anatomical location: stomach
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.02
id: UBERON:0000945

Personal history of other malignant neoplasm of stomach
type: Class
subclass of: Personal history of malignant neoplasm of stomach
definition: adenocarcinoma, primary gastric lymphoma, gastrointestinal stromal tumor (GIST), and neuroendocrine (carcinoid) tumors in the stomach
definition editor: Jennifer Odalys Roman
alternative term: Stomach cancer
definition source: https://rarediseases.org/rare-diseases/stomach-cancer/#:~:text=There%20are%20several%20different%20forms,carcinoid)%20tumors%20in%20the%20stomach.
has icd10 code: Z85.028
code billability: billable
anatomical location: stomach
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.028
id: UBERON:0000945

Personal history of antineoplastic chemotherapy
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: medications used to treat cancer
definition editor: Jennifer Odalys Roman
alternative term: History of chemotherapy
definition source: https://www.cdc.gov/niosh/topics/repro/antineoplastic.html#:~:text=Antineoplastic%20drugs%20are%20medications%20used,are%20pills%20that%20patients%20take.
has icd10 code: Z92.21
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.21

Tracheostomy status
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: a medical procedure — either temporary or permanent — that involves creating an opening in the neck in order to place a tube into a person's windpipe.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/tracheostomy#:~:text=A%20tracheostomy%20is%20a%20medical,air%20to%20enter%20the%20lungs.
has icd10 code: Z93.0
code billability: billable
anatomical location: trachea
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z93-/Z93.0
has_related_synonym: Tracheostomy present
id: UBERON:0003126

New: Bone marrow transplant status
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease, infection, or chemotherapy
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/bone-marrow-transplant#:~:text=A%20bone%20marrow%20transplant%20is,promote%20growth%20of%20new%20marrow.
has icd10 code: Z94.81
code billability: billable
anatomical location: bone marrow
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z94-/Z94.81
has_related_synonym: Growth hormone deficiency after bone marrow transplant
id: UBERON:0002371

Procedure and treatment not carried out because of contraindication
type: Class
subclass of: encounter for prophylactic measures, unspecified
definition: a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient.
definition editor: Jennifer Odalys Roman
definition source: https://medlineplus.gov/ency/article/002314.htm#:~:text=A%20contraindication%20is%20a%20specific,or%20procedures%20are%20used%20together.
has icd10 code: Z53.0
code billability: non-billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z53-/Z53.0

Other problems related to care provider dependency
type: Class
subclass of: factors influencing health status and contact with health services
definition editor: Jennifer Odalys Roman
alternative term: Needs assistance with community resources
definition source: https://icd.codes/icd10cm/Z748
has icd10 code: Z74.8
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.8

New: Other transplanted organ and tissue status
type: Class
subclass of: New: Bone marrow transplant status
definition editor: Jennifer Odalys Roman
has icd10 code: Z94.8
code billability: non-billable
anatomical location: tissue
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z94-/Z94.8
id: UBERON:0000479

Presence of other specified devices
type: Class
subclass of: factors influencing health status and contact with health services
definition editor: Jennifer Odalys Roman
has icd10 code: Z97.8
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z97-/Z97.8
has_related_synonym: Presence of implanted intrathecal pump

Pain localized to upper abdomen
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: Abdominal pain, also known as stomach pain or stomachache, is a common symptom associated with both temporary, non-serious disorders and more serious conditions.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R10-/R10.1
has icd10 code: R10.1
code billability: non-Billable
anatomical location: abdomen
source: https://icd.codes/icd10cm/R101
has_related_synonym: stomach pain or stomachache
id: UBERON:0000916

New: Fecal incontinence
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: voluntary or involuntary fecal soiling in children who have usually already been toilet trained.
definition editor: Jennifer Odays Roman
definition source: https://icd.codes/icd10cm/R15
has icd10 code: R15
code billability: non-Billable
anatomical location: feces
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R15-/R15
has_related_synonym: paradoxical diarrhea
id: UBERON:0001988

New: Anterograde amnesia
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: Anterograde amnesia is a loss of the ability to create new memories after the event that caused the amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remain intact.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/R411
has icd10 code: R41.1
anatomical location: brain
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R41-/R41.1
has_related_synonym: Amnesia, anterograde
id: UBERON:0000955

Very low level of personal hygiene
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition editor: Jennifer Odalys Roman
alternative term: poor hygiene
definition source: https://icd.codes/icd10cm/R460
has icd10 code: R46.0
code billability: Billable
anatomical location: brain
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R46-/R46.0
id: UBERON:0000955

Cachexia
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: A general state of ill health involving marked weight loss and muscle loss.
definition editor: Jennifer Odalys Roman
alternative term: wasting syndrome
definition source: https://icd.codes/icd10cm/R64
has icd10 code: R64
code billability: Billable
anatomical location: body proper
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R64-/R64
id: UBERON:0013702

Respiratory arrest
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: Respiratory arrest is the cessation of normal breathing due to failure of the lungs to function effectively.
definition editor: Jennifer Odalys Roman
has icd10 code: R09.2
code billability: billable
anatomical location: lungs
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R09-/R09.2
id: UBERON:0002048

New: Acute respiratory distress
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: a life-threatening lung injury that allows fluid to leak into the lungs. Breathing becomes difficult and oxygen cannot get into the body.
definition editor: Jennifer Odalys Roman
definition source: https://www.lung.org/lung-health-diseases/lung-disease-lookup/ards#:~:text=Acute%20respiratory%20distress%20syndrome%20(ARDS)%20is%20a%20life%2Dthreatening,hospital%20for%20trauma%20or%20illness.
has icd10 code: R06.03
code billability: billable
anatomical location: pair of lungs
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R06-/R06.03
id: UBERON:0000170

Vomiting, unspecified
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/vomiting-causes-treatment
has icd10 code: R11.10
code billability: billable
anatomical location: stomach
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R11-/R11.10
id: UBERON:0000945

Anhedonia
type: Class
subclass of: symptoms, signs and abnormal clinical and laboratory findings
definition: An inability to experience pleasure from activities usually found enjoyable.
definition editor: Jennifer Odalys Roman
definition source: https://www.webmd.com/depression/what-is-anhedonia
has icd10 code: R45.84
code billability: billable
anatomical location: brain
source: https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R45-/R45.84
id: UBERON:0000955

Enterocolitis due to Clostridium difficile
type: Class
subclass of: infectious and parasitic disease (process)
definition: colitis (inflammation of the large intestine) resulting from infection with Clostridium difficile, a spore-forming bacterium.
definition editor: Jennifer Odalys Roman
alternative term: pseudomembranous colitis
definition source: https://icd.codes/icd10cm/A047
has icd10 code: A04.7
code billability: billable
anatomical location: intestine
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A04-/A04.7
id: UBERON:0000160

Other specified sepsis
type: Class
subclass of: sepsis DP, unspecified organism
definition: Sepsis is a whole-body inflammatory response to an infection.
definition editor: Jennifer Odalys Roman
definition source: https://www.google.com/search
has icd10 code: A41.8
code billability: non-billable
anatomical location: Blood
anatomical location: UBERON:0000178
source: https://icd.codes/icd10cm/A418

Other intestinal Escherichia coli infections
type: Class
subclass of: infectious and parasitic disease (process)
definition: Enteritis (entero- + -itis) is inflammation of the small intestine.
definition editor: Jennifer Odalys Roman
alternative term: Intestinal infection due to e. Coli
definition source: https://icd.codes/icd10cm/A044
has icd10 code: A04.4
code billability: billable
anatomical location: small intestine
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A04-/A04.4
id: UBERON:0002108

Sylvatic yellow fever
type: Class
subclass of: infectious and parasitic disease (process)
definition: The viral hemorrhagic (or haemorrhagic) fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection.
definition editor: Jennifer Odalys Roman
alternative term: Jungle yellow fever
definition source: https://icd.codes/icd10cm/A950
has icd10 code: A95.0
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A90-A99/A95-/A95.0

Urban yellow fever
type: Class
subclass of: Sylvatic yellow fever
definition: The viral hemorrhagic (or haemorrhagic) fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/A951
has icd10 code: A95.1
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/A00-B99/A90-A99/A95-/A95.1

Fracture of neck, unspecified, initial encounter
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: A cervical fracture, commonly called a broken neck, is a catastrophic fracture of any of the seven cervical vertebrae in the neck
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/S129XXA
has icd10 code: S12.9XXA
code billability: billable
anatomical location: neck bone
source: https://icd.codes/icd10cm/S129XXA
id: UBERON:0003458

Unspecified fracture of unspecified thoracic vertebra, initial encounter for closed fracture
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: occur when the bony block or vertebral body in the spine collapses, which can lead to severe pain, deformity and loss of height.
definition source: https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Vertebral-Compression-Fractures#:~:text=Vertebral%20compression%20fractures%20(VCFs)%20occur,especially%20in%20the%20lower%20part.
has icd10 code: S22.009A
code billability: billable
anatomical location: bone spine
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S20-S29/S22-/S22.009A
id: UBERON:0013706

Fracture of clavicle
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: A break in the bone connecting the breastbone and shoulder.
definition editor: Jennifer Odalys Roman
definition source: https://orthoinfo.aaos.org/en/diseases--conditions/clavicle-fracture-broken-collarbone/
has icd10 code: S42.0
code billability: non-billable
anatomical location: clavicle bone
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42/S42.0-/S42.0
id: UBERON:0001105

Unspecified open wound of unspecified forearm, initial encounter
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
example of usage: Gunshot wound of forearm
definition: an injury involving an external or internal break in body tissue, usually involving the skin
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/open-wound#:~:text=An%20open%20wound%20is%20an,can%20be%20treated%20at%20home.
has icd10 code: S51.809A
code billability: billable
anatomical location: skin of forearm
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S50-S59/S51-/S51.809A
id: UBERON:0003403

Subluxation and dislocation of wrist and hand joints
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: A network of ligaments holds them in place and allows them to move. A tear in any of these ligaments can result in two or more of your carpal bones being pushed out of their usual position
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/dislocated-wrist
has icd10 code: S63.0
code billability: non-billable
anatomical location: wrist joint
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S60-S69/S63/S63.0-/S63.0
id: UBERON:0001491

Fracture of unspecified part of neck of unspecified femur, sequela
type: Class
subclass of: fracture of head and neck of femur DP
definition: A hip fracture is a serious femoral fracture that occurs in the proximal end of the femur (the long bone running through the thigh), near the hip.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/femoral-neck-fracture#:~:text=Femoral%20neck%20stress%20fracture%20causes,is%20also%20a%20risk%20factor.
has icd10 code: S72.009S
code billability: billable
anatomical location: femur
source: https://icd.codes/icd10cm/S72009S
id: UBERON:0000981

Unspecified trochanteric fracture of unspecified femur, initial encounter for closed fracture
type: Class
subclass of: fracture of head and neck of femur DP
definition: the proximal femur between the cervical region and the shaft. Subtrochanteric fracture, with a fracture line running from an area within 5 cm distal to the lesser trochanter
has icd10 code: S72.109A
code billability: billable
anatomical location: femur
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.1-/S72.109A
id: UBERON:0000981

Unspecified physeal fracture of upper end of unspecified femur, sequela
type: Class
subclass of: traumatic ischemia DP of muscle
definition: disruptions in the cartilaginous physis of long bones that may or may not involve epiphyseal or metaphyseal bone.
definition source: Jennifer Odalys Roman
definition source: https://emedicine.medscape.com/article/1260663-overview
has icd10 code: S79.009S
code billability: billable
anatomical location: cartilaginous joint
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S79-/S79.009S
id: UBERON:0002213

Unspecified fracture of unspecified patella, sequela
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: is a break in the patella, or kneecap, the small bone that sits at the front of your knee
definition editor: Jennifer Odalys Roman
definition source: https://orthoinfo.aaos.org/en/diseases--conditions/patellar-kneecap-fractures/
has icd10 code: S82.009S
code billability: billable
anatomical location: knee
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S80-S89/S82/S82.0-/S82.009S
id: UBERON:0001465

Unspecified fracture of unspecified lower leg, sequela
type: Class
subclass of: Unspecified fracture of unspecified patella, sequela
definition: a break or crack in one of the bones in your leg.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/broken-leg/symptoms-causes/syc-20370412#:~:text=Overview,and%20severity%20of%20the%20injury.
has icd10 code: S82.90XS
anatomical location: leg
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S80-S89/S82/S82.9-/S82.90XS
id: UBERON:0000978

New: Fracture of unspecified metatarsal bone(s), left foot, subsequent encounter for fracture with routine healing
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: a complete or incomplete break in one of the five metatarsal bones in each foot.
definition editor: Jennifer Odalys Roman
definition source: https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/metatarsal-fractures#:~:text=Acute%20metatarsal%20fracture%20is%20usually,bone%2C%20caused%20by%20repetitive%20stress.
has icd10 code: S92.302D
anatomical location: metatarsal bone
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S90-S99/S92/S92.3-/S92.302D
id: UBERON:0001448

New: Unspecified fracture of unspecified foot, sequela
type: Class
subclass of: New: Fracture of unspecified metatarsal bone(s), left foot, subsequent encounter for fracture with routine healing
definition: a bone break that happens in the bones of your foot, heel, toes, or ankle. There are different types of foot fractures, but the most common is a hairline fracture.
definition editor: Jennifer Odalys Roman
definition source: https://intermountainhealthcare.org/services/orthopedics/services/foot-and-ankle/foot-fractures/#:~:text=A%20foot%20fracture%20is%20a,common%20is%20a%20hairline%20fracture.
has icd10 code: S92.909S
anatomical location: billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S90-S99/S92/S92.9-/S92.919S

New: Unspecified fracture of unspecified toe(s), sequela
type: Class
subclass of: New: Fracture of unspecified metatarsal bone(s), left foot, subsequent encounter for fracture with routine healing
definition: Wound healing is a critical outcome in surgery, and postoperative wound disruption or separation of the layers of a surgical wound with disruption of the fascia is a serious complication
definition editor: Jennifer Odalys Roman
definition source: https://www.patientsafetyinstitute.ca/en/toolsResources/Hospital-Harm-Measure/Improvement-Resources/Wound%20Disruption-Introduction/Pages/default.aspx
has icd10 code: S92.919S
code billability: billable
anatomical location: toe disc
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/S90-S99/S92/S92.9-/S92.919S
id: UBERON:4200151

Disruption of external operation (surgical) wound, not elsewhere classified
type: Class
subclass of: complications of procedures
definition: Pathologic process consisting of a partial or complete disruption of the layers of a surgical wound.
definition editor: Jennifer Odalys Roman
has icd10 code: T81.31
code billability: non-billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.31

Disruption of external operation (surgical) wound, not elsewhere classified, initial encounter
type: Class
subclass of: complications of procedures
definition: Pathologic process consisting of a partial or complete disruption of the layers of a surgical wound.
definition editor: Jennifer Odalys Roman
has icd10 code: T81.31XA
code billability: billable
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.31XA

Other mechanical complication of infusion catheter, initial encounter
type: Class
subclass of: injury, poisoning and certain other consequences of external causes
definition: Complications of gaining I.V. may include infiltration, hematoma, an air embolism, phlebitis, extravascular drug administration, and intraarterial injection. Intraarterial injection is more rare, but as threatening.
definition editor: Jennifer Odalys Roman
definition source: https://ccnmtl.columbia.edu/projects/aegd/mod01_mec_ivcomp.html
has icd10 code: T82.594A
code billability: billable
anatomical location: urinary bladder
source: https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.594A
id: UBERON:0001255

Secondary and unspecified malignant neoplasm of intrathoracic lymph nodes
type: Class
subclass of: neoplasm DP
definition: used to specify a diagnosis of secondary and unspecified malignant neoplasm of intrathoracic lymph nodes.
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/medgen/673463
has icd10 code: C77.1
code billability: Billable
anatomical location: lymph node
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C77-/C77.1
id: UBERON:0000029

New: Chronic lymphocytic leukemia of B-cell type
type: Class
subclass of: neoplasm DP
definition: A rare condition in which chronic lymphocytic leukemia (cll) changes into a fast-growing type of lymphoma. Symptoms of richter syndrome include fever, loss of weight and muscle mass, and other health problems.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/C911
has icd10 code: C91.1
code billability: Non-Billable
anatomical location: blood
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.1
id: UBERON:0000178

New: Chronic lymphocytic leukemia of B-cell type not having achieved remission
type: Class
subclass of: New: Chronic lymphocytic leukemia of B-cell type
definition: B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most common type of leukemia (a type of cancer of the white blood cells) in adults.
definition editor: Jennifer Odalys Roman
definition source: https://icd.codes/icd10cm/C9110
has icd10 code: C91.10
code billability: Billable
anatomical location: lymph nodes
source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.10
id: UBERON:0000029

New: Drug-induced aplastic anemia
type: Class
subclass of: neoplasm DP
definition: A state of bone marrow suppression and failure that is caused by a cytotoxic or adverse immunologic response to a drug treatment, leading to a failure of production of red blood cells, white cells and platelets.
definition editor: Jennifer Odalys Roman
has icd10 code: D61.1
code billability: Billable
anatomical location: bone marrow
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D61-/D61.1
id: UBERON:0002371

Malignant neoplasm of kidney, except renal pelvis
type: Class
subclass of: neoplasm DP
definition: Renal cell carcinoma is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine.
definition editor: Jennifer Odalys Roman
definition source: http://www.globenewswire.com/news-release/2020/03/27/2007560/0/en/Renal-Cell-Carcinoma-Epidemiology-Forecast-to-2028.html
has icd10 code: C64
code billability: non-billable
anatomical location: kidney
source: https://icd.codes/icd10cm/C64
id: UBERON:0002113

Malignant neoplasm of bladder, unspecified
type: Class
subclass of: neoplasm DP
definition: Bladder cancer is any of several types of cancer arising from the epithelial lining of the urinary bladder.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/C00-D49/C64-C68/C67-/C67.9
has icd10 code: C67.9
code billability: billable
anatomical location: gall bladder
source: https://icd.codes/icd10cm/C679
id: UBERON:0002110

Secondary malignant neoplasm of retroperitoneum and peritoneum
type: Class
subclass of: secondary malignant neoplasm of liver and intrahepatic bile duct DP
definition: Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites.
definition editor: Jennifer Odalys Roman
has icd10 code: C78.9
code billability: billable
anatomical location: abdominal cavity
source: https://icd.codes/icd10cm/C786
id: UBERON:0003684

Immune thrombocytopenic purpura
type: Class
subclass of: neoplasm DP
definition: Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets.
definition editor: Jennifer Odalys Roman
definition source: https://www.google.com/search
has icd10 code: D69.3
code billability: billable
anatomical location: Blood
source: https://icd.codes/icd10cm/D693
id: UBERON:0000178

Other specified immunodeficiencies
type: Class
subclass of: neoplasm DP
definition: An immune disorder is a dysfunction of the immune system.
definition editor: Jennifer Odalys Roman
has icd10 code: D84.8
code billability: billable
anatomical location: tissue
source: https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D84-/D84.8
id: UBERON:0000479

Benign neoplasm of lip
type: Class
subclass of: neoplasm DP
definition: A neoplasm without malignant characteristics arising from the lip.
definition editor: Jennifer Odalys Roman
has icd10 code: D10.0
anatomical location: lip
source: https://icd.codes/icd10cm/D100
id: UBERON:0001833

New: Respiratory arrest
type: Class
subclass of: New: Acute respiratory distress
definition: Respiratory arrest is the cessation of normal breathing due to failure of the lungs to function effectively.
alternative term: Cardiorespiratory failure
has icd10 code: R09.2
code billability: billable
anatomical location: lungs
id: UBERON:0002048

*acute sinusitis
type: Class
subclass of: acute upper respiratory infections
definition: A condition in which the cavities around the nasal passages become inflamed.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/acute-sinusitis/symptoms-causes/syc-20351671
has icd10 code: J01
code billability: Non-Billable
has ICD10 name: Acute Sinusitis

Parainfluenza virus pneumonia
type: Class
subclass of: *Viral pneumonia, not elsewhere classified
definition: An infection that inflames the air sacs in one or both lungs caused by Parainfluenza virus
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J12-/J12.2
has icd10 code: J12.2
code billability: Billable
terminology_notes: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
has ICD10 name: Jennifer Odalys Roman
has ICD10 name: Parainfluenza virus pneumonia

Other viral pneumonia
type: Class
subclass of: other viral pneumonia
definition: a disease that attacks one or both lungs, virus is unspecified
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/pneumonia#:~:text=Pneumonia%20is%20an%20infection%20in,and%20how%20to%20treat%20it.
has icd10 code: J12.89
code billability: Billable
anatomical location: lungs

Pneumonia due to Klebsiella pneumoniae
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: Pneumonia (infection that inflames the air sacs in the lungs) caused by Klebsiella pneumoniae bacteria
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.0
has icd10 code: J15.0
code billability: Billable
anatomical location: lung

Pneumonia due to Pseudomonas
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: Pneumonia (infection that inflames the air sacs in the lungs) caused by Pseudomonas bacteria
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.1
has icd10 code: J15.1
code billability: Billable
anatomical location: lung

Pneumonia due to Escherichia coli
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: An infection that inflames the air sacs in one or both lungs caused by Escherichia coli bacteria
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.5
has icd10 code: J15.5
code billability: Billable
terminology_notes: https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia.
anatomical location: lung

Pneumonia due to other specified infectious organisms
type: Class
subclass of: *Pneumonia due to other infectious organisms, not elsewhere classified
definition: infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J16-/J16.8
has icd10 code: J16.8
code billability: Billable
anatomical location: lungs
has ICD10 name: Pneumonia due to other specified infectious organisms

*Acute pharyngitis
type: Class
subclass of: acute upper respiratory infections
definition: Pharyngitis, or acute pharyngitis, is an inflammation of the back of the throat, otherwise known as the pharynx. The condition generally causes pain and a sensation of scratchiness in the region of the throat, as well as difficulty swallowing. The condition is typically referred to as a sore throat.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J02-
has icd10 code: J02
code billability: Non-Billable
has ICD10 name: Acute pharyngitis

*Acute tonsillitis
type: Class
subclass of: acute upper respiratory infections
definition: An inflammation of the two oval-shaped pads of tissue at the back of the throat.
definition editor: Jennifer Odalys Roman
definition source: https://pubmed.ncbi.nlm.nih.gov/22338587/
has icd10 code: J03
code billability: Non-Billable
has ICD10 name: Acute tonsillitis

*Acute laryngitis and tracheitis
type: Class
subclass of: acute upper respiratory infections
definition: Laryngitis may cause sore throat and hoarse voice but can also be associated with tracheitis and even bronchiolitis as the pathogen, infection, and host responses move further down the respiratory tree.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J04-/J04
has icd10 code: J04
code billability: Non-Billable

*Acute obstructive laryngitis [croup] and epiglottitis
type: Class
subclass of: acute upper respiratory infections
definition: Epiglottitis, acute laryngitis, and croup are infections of the upper airway, affecting the epiglottis, larynx, and larynx and trachea, respectively. Croup may also involve the bronchi.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J05-/J05
has icd10 code: J05
code billability: non-billable
has ICD10 name: Acute obstructive laryngitis [croup] and epiglottitis

*Bronchitis, not specified as acute or chronic
type: Class
subclass of: chronic lower respiratory diseases
definition: (bron-kye-tis) inflammation (swelling and reddening) of the bronchi.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J40-/J40
has icd10 code: J40
code billability: Billable
has ICD10 name: Bronchitis, not specified as acute or chronic

*Simple and mucopurulent chronic bronchitis
type: Class
subclass of: chronic lower respiratory diseases
definition: Mucoid sputum production characterizes simple chronic bronchitis. Persistent or recurrent purulent sputum production in the absence of localized suppurative disease, such as bronchiectasis, characterizes chronic mucopurulent bronchitis
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J41-/J41
has icd10 code: J41
code billability: non-billable
has ICD10 name: Simple and mucopurulent chronic bronchitis

*Unspecified chronic bronchitis
type: Class
subclass of: chronic lower respiratory diseases
definition: A subcategory of chronic obstructive pulmonary disease. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J42-/J42
has icd10 code: J42
code billability: billable
has ICD10 name: Unspecified chronic bronchitis

*Emphysema
type: Class
subclass of: chronic lower respiratory diseases
definition: A condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43
has icd10 code: J43
code billability: non-billable
has ICD10 name: Emphysema

Acute bronchitis due to rhinovirus
type: Class
subclass of: *Acute bronchitis
definition: contagious viral infection caused by rhinovirus that causes inflammation of the bronchial tubes
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20.6
has icd10 code: J20.6
code billability: Billable
anatomical location: bronchial tubes
has ICD10 name: Acute bronchitis due to rhinovirus

*Asthma
type: Class
subclass of: chronic lower respiratory diseases
definition: A chronic disease in which the bronchial airways in the lungs become narrowed and swollen, making it difficult to breathe. Symptoms include wheezing, coughing, tightness in the chest, shortness of breath, and rapid breathing. An attack may be brought on by pet hair, dust, smoke, pollen, mold, exercise, cold air, or stress.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J45-/J45
has icd10 code: J45
code billability: non-billable
has ICD10 name: Asthma

*Influenza due to certain identified influenza viruses
type: Class
subclass of: influenza due to pathogen
definition: Influenza is a viral infection that attacks your respiratory system — your nose, throat and lungs.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J09-/J09
has icd10 code: J09
code billability: non-billable
has ICD10 name: Influenza due to certain identified influenza viruses

*Influenza due to other identified influenza virus
type: Class
subclass of: influenza due to pathogen
definition: Influenza, commonly known as "the flu", is an infectious disease caused by an influenza virus. Symptoms can be mild to severe.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J10-/J10
has icd10 code: J10
code billability: non-billable
has ICD10 name: Influenza due to other identified influenza virus

*Influenza due to unidentified influenza virus
type: Class
subclass of: influenza due to pathogen
definition: Influenza due to unidentified influenza virus with other respiratory manifestations
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11
has icd10 code: J11
code billability: non-billable
has ICD10 name: Influenza due to unidentified influenza virus

*Viral pneumonia, not elsewhere classified
type: Class
subclass of: influenza due to pathogen
definition: Viral pneumonia is an infection of your lungs caused by a virus.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J12-/J12
has icd10 code: J12
code billability: non-billable
has ICD10 name: Viral pneumonia, not elsewhere classified

*Pneumonia due to Streptococcus pneumoniae
type: Class
subclass of: influenza due to pathogen
definition: Pneumococcal disease is caused by common bacteria (Streptococcus pneumoniae) that can attack different parts of the body. When these bacteria invade the lungs, they can cause pneumonia; when they invade the bloodstream, they can cause sepsis; and when they invade the covering of the brain, they can cause meningitis.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J13-/J13
has icd10 code: J13
code billability: billable
has ICD10 name: Pneumonia due to Streptococcus pneumoniae

*Acute upper respiratory infections of multiple and unspecified sites
type: Class
subclass of: acute upper respiratory infections
definition: An acute URI is a contagious infection of your upper respiratory tract. Your upper respiratory tract includes the nose, throat, pharynx, larynx, and bronchi.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J06-/J06
has icd10 code: J06
has ICD10 name: Acute upper respiratory infections of multiple and unspecified sites

*Pneumonia due to Hemophilus influenzae
type: Class
subclass of: influenza due to pathogen
definition: H. influenzae most often cause pneumonia, but can also cause severe illnesses like meningitis and bloodstream infections
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J14-/J14
has icd10 code: J14
code billability: billable
has ICD10 name: Pneumonia due to Hemophilus influenzae

*Bacterial pneumonia, not elsewhere classified
type: Class
subclass of: influenza due to pathogen
definition: Inflammation of the lung parenchyma that is caused by bacterial infections.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15
has icd10 code: J15
code billability: non-billable
has ICD10 name: Bacterial pneumonia, not elsewhere classified

*Pneumonia due to other infectious organisms, not elsewhere classified
type: Class
subclass of: influenza due to pathogen
definition: Pneumonia is an infection of one or both of the lungs caused by bacteria, viruses, or fungi.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J16-/J16
has icd10 code: J16
code billability: non-billable
has ICD10 name: Pneumonia due to other infectious organisms, not elsewhere classified

*Pneumonia in diseases classified elsewhere
type: Class
subclass of: influenza due to pathogen
definition: Infection that inflames air sacs in one or both lungs, which may fill with fluid.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J17-/J17
has icd10 code: J17
code billability: billable
has ICD10 name: Pneumonia in diseases classified elsewhere

*Respiratory conditions due to other external agents
type: Class
subclass of: lung disease processes due to external agents
definition: A type of disease that affects the lungs and other parts of the respiratory system
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J70-/J70
has icd10 code: J70
code billability: non-billable
has ICD10 name: Respiratory conditions due to other external agents

*Pneumonitis due to solids and liquids
type: Class
subclass of: lung disease processes due to external agents
definition: Pneumonitis (noo-moe-NIE-tis) is a general term that refers to inflammation of lung tissue
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J69-
has icd10 code: J69
code billability: non-billable
has ICD10 name: Pneumonitis due to solids and liquids

*Respiratory conditions due to inhalation of chemicals, gases, fumes and vapors
type: Class
subclass of: lung disease processes due to external agents
definition: Respiratory conditions due to inhalation of chemicals, gases, fumes and vapors
definition editor: Jennfer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J68-/J68
has icd10 code: J68
code billability: non-billable
has ICD10 name: Respiratory conditions due to inhalation of chemicals, gases, fumes and vapors

*Hypersensitivity pneumonitis due to organic dust
type: Class
subclass of: lung disease processes due to external agents
definition: allergic alveolitis and pneumonitis due to inhaled organic dust and particles of fungal, actinomycetic or other origin
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J67-/J67
has icd10 code: J67
code billability: non-billable
has ICD10 name: Hypersensitivity pneumonitis due to organic dust

*Airway disease due to specific organic dust
type: Class
subclass of: lung disease processes due to external agents
definition: Pneumoconiosis is one of a group of interstitial lung disease caused by breathing in certain kinds of dust particles that damage your lungs.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J66-/J66
has icd10 code: J66
code billability: non-billable
has ICD10 name: Airway disease due to specific organic dust

*Pneumoconiosis associated with tuberculosis
type: Class
subclass of: lung disease processes due to external agents
definition: Pneumoconiosis is one of a group of interstitial lung disease caused by breathing in certain kinds of dust particles that damage your lungs
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J65-/J65
has icd10 code: J65
code billability: billable
has ICD10 name: Pneumoconiosis associated with tuberculosis

*Unspecified pneumoconiosis
type: Class
subclass of: lung disease processes due to external agents
definition: A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (asbestosis; byssinosis; and others). Similar air pollution can also have deleterious effects on the general population.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J64-/J64
code billability: billable
has ICD10 name: J64
has ICD10 name: Unspecified pneumoconiosis

*Pneumoconiosis due to other inorganic dusts
type: Class
subclass of: lung disease processes due to external agents
definition: Pneumoconiosis literally means “dust in the lung,” and the term has come to refer to disease of the lung related to the inhalation of dusts.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J63-/J63
has icd10 code: J63
code billability: non-billable
has ICD10 name: Pneumoconiosis due to other inorganic dusts

*Pneumoconiosis due to dust containing silica
type: Class
subclass of: lung disease processes due to external agents
definition: A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of silicon dioxide, usually in the form of quartz. Amorphous silica is relatively nontoxic.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J62-/J62
has icd10 code: J62
code billability: non-billable
has ICD10 name: Pneumoconiosis due to dust containing silica

*Pneumoconiosis due to asbestos and other mineral fibers
type: Class
subclass of: lung disease processes due to external agents
definition: A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J61-/J61
has icd10 code: J61
code billability: billable
has ICD10 name: Pneumoconiosis due to asbestos and other mineral fibers

*Coalworker's pneumoconiosis
type: Class
subclass of: lung disease processes due to external agents
definition: A chronic lung disorder characterized by deposition of coal dust in the lung parenchyma leading to the formation of black nodules and emphysema. It occurs in coal miners.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J60-J70/J60-/J60
has icd10 code: J60
code billability: billable
has ICD10 name: Coalworker's pneumoconiosis

*Acute bronchitis
type: Class
subclass of: other acute lower respiratory infections
definition: Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It causes a cough that often brings up mucus, as well as shortness of breath, wheezing, and chest tightness.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20
has icd10 code: J20
code billability: non-billable
has ICD10 name: Acute bronchitis

*Acute bronchiolitis
type: Class
subclass of: other acute lower respiratory infections
definition: Bronchiolitis is an acute inflammatory injury of the bronchioles that is usually caused by a viral infection (most commonly respiratory syncytial virus)
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J21-/J21
has icd10 code: J21
code billability: non-billable
has ICD10 name: Acute bronchiolitis

*Pleural plaque
type: Class
subclass of: other diseases of the pleura
definition: Pleural plaques are deposits of hyalinized collagen fibers in the parietal pleura.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J90-J94/J92-/J92
has icd10 code: J92
code billability: non-billable
has ICD10 name: Pleural plaque

*Pneumothorax and air leak
type: Class
subclass of: other diseases of the pleura
definition: The most frequent air leak, called a pneumothorax, is when the air collects between the lung and the chest wall.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J90-J94/J93-/J93
has icd10 code: J93
code billability: non-billable
has ICD10 name: Pneumothorax and air leak

*Other pleural conditions
type: Class
subclass of: other diseases of the pleura
definition: There are three types of pleural disorders—pleurisy, pleural effusion, and pneumothorax—and they have varying causes.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J90-J94/J94-/J94
has icd10 code: J94
code billability: non-billable
has ICD10 name: Other pleural conditions

*Respiratory disorders in diseases classified elsewhere
type: Class
subclass of: other diseases of the respiratory system
definition: Respiratory disorders, or lung diseases, are disorders such as asthma, cystic fibrosis, emphysema, lung cancer, mesothelioma, pulmonary hypertension, and tuberculosis.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J99-/J99
has icd10 code: J99
code billability: billable
has ICD10 name: Respiratory disorders in diseases classified elsewhere

*Other respiratory disorders
type: Class
subclass of: other diseases of the respiratory system
definition: Respiratory disorders, or lung diseases, are disorders such as asthma, cystic fibrosis, emphysema, lung cancer, mesothelioma, pulmonary hypertension, and tuberculosis.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98
has icd10 code: J98
code billability: non-billable
has ICD10 name: Other respiratory disorders

*Respiratory failure, not elsewhere classified
type: Class
subclass of: other diseases of the respiratory system
definition: When a person has acute respiratory failure, the usual exchange between oxygen and carbon dioxide in the lungs does not occur.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J96-/J96
has icd10 code: J96
code billability: non-billable
has ICD10 name: Respiratory failure, not elsewhere classified

*Pulmonary eosinophilia, not elsewhere classified
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition: Simple pulmonary eosinophilia (SPE), also known as Loeffler syndrome, is a rare, temporary (transient) respiratory disorder characterized by the accumulation of eosinophils in the lungs (pulmonary eosinophilia). Eosinophils are a type of white blood cell and are part of the immune system.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J82-/J82
has icd10 code: J82
code billability: non-billable
has ICD10 name: Pulmonary eosinophilia, not elsewhere classified

*Other interstitial pulmonary diseases
type: Class
subclass of: other respiratory diseases affecting the interstitum
definition: Interstitial pneumonia, Idiopathic pulmonary fibrosis, Nonspecific interstitial pneumonitis
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J84-/J84
has icd10 code: J84
code billability: non-billable
has ICD10 name: Other interstitial pulmonary diseases

Acute bronchiolitis, unspecified
type: Class
subclass of: *Acute bronchiolitis
definition: an acute inflammatory injury of the bronchioles that is usually caused by a viral infection
definition editor: Jennifer Odalys Roman
definition source: https://emedicine.medscape.com/article/961963-overview#:~:text=Bronchiolitis%20is%20an%20acute%20inflammatory,seen%20in%20the%20image%20below.
has icd10 code: J21.9
code billability: Billable
anatomical location: bronchioles

Emphysema, unspecified
type: Class
subclass of: *Emphysema
definition: A condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.9
has icd10 code: J43.9
code billability: Billable
anatomical location: lung

Nonallergic asthma
type: Class
subclass of: *Asthma
definition: Nonallergic asthma (a condition in which your airways narrow and swell)
definition editor: Jennifer Odalys Roman
definition source: https://icd.who.int/browse10/2016/en#/J45.1
has icd10 code: J45.1
anatomical location: respiratory system

Mild intermittent asthma, uncomplicated
type: Class
subclass of: *Asthma
definition: Asthma symptoms (airway swelling) occuring fewer than three times a week
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J45-/J45.20
has icd10 code: J45.20
code billability: billable
anatomical location: respiratory system
has ICD10 name: Mild intermittent asthma, uncomplicated

Intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
type: Class
subclass of: disease (process) in the respiratory system
definition: complications/disorders of the respiratory system that occur during or after a procedure/operation
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J95-J95/J95-/J95
has icd10 code: J95
code billability: non-billable
anatomical location: respiratory system
has ICD10 name: Intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Diseases of bronchus, not elsewhere classified
type: Class
subclass of: *Other respiratory disorders
definition: disease of the bronchus
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.0
has icd10 code: J98.0
code billability: non-billable
anatomical location: bronchus
has ICD10 name: Diseases of bronchus, not elsewhere classified

Respiratory infection, not elsewhere classified
type: Class
subclass of: *Other respiratory disorders
definition: Respiratory tract infections not specified as acute, chronic, lower, or upper
definition editor: Jennifer Odalys Roman
definition source: https://icd.who.int/browse10/2019/en#/J98.7
has icd10 code: J98.7
anatomical location: respiratory system
has ICD10 name: Respiratory infection, not elsewhere classified

Respiratory disorders in other diseases classified elsewhere
type: Class
subclass of: *Respiratory disorders in diseases classified elsewhere
definition: respiratory disorder as a result of another disorder found elsewhere in the body
definition editor: Jennifer Odalys Roman
definition source: https://icd.who.int/browse10/2016/en#/J99.8
has icd10 code: J99.8
anatomical location: respiratory system
has ICD10 name: Respiratory disorders in other diseases classified elsewhere

Acute maxillary sinusitis
type: Class
subclass of: *acute sinusitis
definition: facial pain, localized to the cheek, but also in the frontal area or the teeth, that is made worse by stooping down or straining. The pain can be unilateral or bilateral, and tenderness may overlie the sinus.
definition editor: Jennifer Odalys Roman
definition source: https://www.sciencedirect.com/topics/medicine-and-dentistry/maxilla-sinusitis#:~:text=Acute%20maxillary%20sinusitis%20is%20characterized,tenderness%20may%20overlie%20the%20sinus.
has icd10 code: J01.0
code billability: Non-Billable
anatomical location: sinuses

Acute maxillary sinusitis, unspecified
type: Class
subclass of: Acute maxillary sinusitis
definition: Acute sinusitis causes the spaces inside your nose (sinuses) to become inflamed and swollen.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/acute-sinusitis/symptoms-causes/syc-20351671
has icd10 code: J01.00
code billability: billable
anatomical location: sinuses
has ICD10 name: Acute maxillary sinusitis, unspecified

Acute frontal sinusitis, unspecified
type: Class
subclass of: *acute sinusitis
definition: Acute frontal sinusitis (AFrS) is defined as an acute bacterial infection of the frontal sinus cavity.
definition editor: Jennifer Odalys Roman
definition source: https://emedicine.medscape.com/article/862292-overview
has icd10 code: J01.10
code billability: billable
anatomical location: sinuses
has ICD10 name: Acute frontal sinusitis, unspecified

Other acute sinusitis
type: Class
subclass of: *acute sinusitis
definition: Acute sinusitis causes the spaces inside your nose (sinuses) to become inflamed and swollen
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/acute-sinusitis/symptoms-causes/syc-20351671
has icd10 code: J01.8
code billability: Non-Billable
anatomical location: sinuses
has ICD10 name: Other acute sinusitis

Acute sinusitis, unspecified
type: Class
subclass of: *acute sinusitis
definition: Acute sinusitis is most often caused by the common cold. Signs and symptoms may include a blocked and stuffy (congested) nose, which may block your sinuses and prevent drainage of mucus.
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/acute-sinusitis/symptoms-causes/syc-20351671#:~:text=Acute%20sinusitis%20is%20most%20often,an%20infection%20with%20a%20virus.
has icd10 code: J01.90
code billability: billable
anatomical location: sinuses
has ICD10 name: Acute sinusitis, unspecified

Streptococcal pharyngitis
type: Class
subclass of: *Acute pharyngitis
definition: Strep throat is caused by infection with a bacterium known as Streptococcus pyogenes, also called group A streptococcus
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/strep-throat/symptoms-causes/syc-20350338
has icd10 code: J02.0
code billability: billable
anatomical location: throat
has ICD10 name: Streptococcal pharyngitis

Acute pharyngitis due to other specified organisms
type: Class
subclass of: *Acute pharyngitis
definition: Acute pharyngitis is characterized by the rapid onset of sore throat and pharyngeal inflammation (with or without exudate)
definition editor: Jennifer Odalys Roman
definition source: https://bestpractice.bmj.com/topics/en-us/5#:~:text=Definition,%2C%20rather%20than%20viral%2C%20etiology.
has icd10 code: J02.8
code billability: billable

Acute tonsillitis, unspecified
type: Class
subclass of: *Acute tonsillitis
definition: An acute inflammation of the tonsils caused by viruses or bacteria. Signs and symptoms include fever, enlargement of the tonsils, difficulty swallowing, and enlargement of the regional lymph nodes.
definition editor: Jennifer Odalys Roman
definition source: https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J03-/J03.9
has icd10 code: J03.9
code billability: non-billable
anatomical location: tonsils

Acute laryngitis
type: Class
subclass of: *Acute laryngitis and tracheitis
definition: Acute laryngitis is characterized by inflammation and congestion of the larynx in the early stages
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/books/NBK534871/
has icd10 code: J04.0
code billability: billable
anatomical location: larynx

Influenza due to other identified influenza virus with other specified pneumonia
type: Class
subclass of: *Influenza due to other identified influenza virus
definition: Influenza is a common cause of pneumonia, especially among younger children, the elderly, pregnant women, or those with certain chronic health conditions or who live in a nursing home
definition editor: Jennifer Odalys Roman
definition source: https://www.lung.org/lung-health-diseases/lung-disease-lookup/pneumonia/what-is-the-connection
has icd10 code: J10.08
code billability: billable
anatomical location: lung

Influenza due to other identified influenza virus with other manifestations
type: Class
subclass of: *Influenza due to other identified influenza virus
definition: Influenza is a common cause of pneumonia, especially among younger children, the elderly, pregnant women, or those with certain chronic health conditions or who live in a nursing home
definition editor: Jennifer Odalys Roman
definition source: https://icd.who.int/browse10/2019/en#/J10.8
has icd10 code: J10.8
code billability: non-billable
anatomical location: upper respiratory
has ICD10 name: Influenza due to other identified influenza virus with other manifestations

Influenza due to unidentified influenza virus with unspecified type of pneumonia
type: Class
subclass of: *Influenza due to unidentified influenza virus
definition: Flu (influenza) is an infection of the nose, throat and lungs, which are part of the respiratory system. Influenza is commonly called the flu, but it's not the same as stomach "flu" viruses that cause diarrhea and vomiting
definition editor: Jennifer Odalys Roman
definition source: https://www.mayoclinic.org/diseases-conditions/flu/symptoms-causes/syc-20351719
has icd10 code: J11.00
code billability: billable
anatomical location: throat

Adenoviral pneumonia
type: Class
subclass of: *Viral pneumonia, not elsewhere classified
definition: Adenovirus pneumonia occasionally occurs in immunocompromised hosts and is characterized by rapid clinical deterioration compared to other viral pneumonias with a reported fatality rate of 50%.
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241922/#:~:text=Adenovirus%20pneumonia%20occasionally%20occurs%20in,immunocompetent%20hosts%20is%20very%20rare.
has icd10 code: J12.0
code billability: billable
anatomical location: respiratory tract
has ICD10 name: Adenoviral pneumonia

Respiratory syncytial virus pneumonia
type: Class
subclass of: *Viral pneumonia, not elsewhere classified
definition: RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States.
definition editor: Jennifer Odalys Roman
definition source: https://www.cdc.gov/rsv/index.html#:~:text=RSV%20is%20the%20most%20common,age%20in%20the%20United%20States.&text=Know%20the%20symptoms%20to%20look,care%20for%20people%20with%20RSV.&text=RSV%20can%20be%20dangerous%20for%20some%20infants%20and%20young%20children.
has icd11 code: J12.1
code billability: Billable
anatomical location: lung
has ICD10 name: Respiratory syncytial virus pneumonia

Human metapneumovirus pneumonia
type: Class
subclass of: *Viral pneumonia, not elsewhere classified
definition: Human metapneumovirus is a negative-sense single-stranded RNA virus of the family Pneumoviridae and is closely related to the Avian metapneumovirus subgroup C.
definition editor: Jennifer Odalys Roman
definition source: https://www.cdc.gov/surveillance/nrevss/hmpv/clinical.html
has icd10 code: J12.3
code billability: billable
anatomical location: upper and lower respiratory tract
has ICD10 name: Human metapneumovirus pneumonia

Pneumonia due to Methicillin susceptible Staphylococcus aureus
type: Class
subclass of: pneumonia due to staphylococcus
definition: MSSA, or methicillin-susceptible Staphylococcus aureus, is an infection caused by a type of bacteria commonly found on the skin.
definition editor: Jennifer Odalys Roman
definition source: https://www.healthline.com/health/mssa
has icd10 code: J15.211
code billability: billable
anatomical location: lung
has ICD10 name: Pneumonia due to Methicillin susceptible Staphylococcus aureus

Pneumonia due to streptococcus, group B
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: Group B (i.e.,Streptococcus agalactiae) streptococci are a major cause of neonatal sepsis and pneumonia. In adults, pneumonia accounts for approximately 15% of adult infections by group B streptococci. Most adults with group B streptococcal pneumonia are debilitated and develop pneumonia as a consequence of aspiration.
definition editor: Jennifer Odalys Roman
definition source: https://www.sciencedirect.com/topics/medicine-and-dentistry/group-b-streptococcal-pneumonia#:~:text=Group%20B%20(i.e.%2CStreptococcus%20agalactiae,infections%20by%20group%20B%20streptococci.&text=Most%20adults%20with%20group%20B,as%20a%20consequence%20of%20aspiration.
has icd11 code: J15.3
code billability: billable
anatomical location: lung
has ICD10 name: Pneumonia due to streptococcus, group B

Pneumonia due to other streptococci
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: Streptococcus pneumoniae is a gram-positive, lancet-shaped bacterium and a cause of community-acquired pneumonia.
definition editor: Jennifer Odalys Roman
definition source: https://www.ncbi.nlm.nih.gov/books/NBK470537/
has icd10 code: J15.4
code billability: billable
anatomical location: respiratory tract
has ICD10 name: Pneumonia due to other streptococci

Pneumonia due to Mycoplasma pneumoniae
type: Class
subclass of: *Bacterial pneumonia, not elsewhere classified
definition: Pneumonia is inflamed or swollen lung tissue due to infection with a germ. Mycoplasma pneumonia is caused by the bacteria Mycoplasma pneumoniae (M pneumoniae). This type of pneumonia is also called atypical pneumonia because the symptoms are different from those of pneumonia due to other common bacteria.
definition editor: Jennifer Odalys Roman
definition source: https://www.mountsinai.org/health-library/diseases-conditions/mycoplasma-pneumonia#:~:text=Pneumonia%20is%20inflamed%20or%20swollen,due%20to%20other%20common%20bacteria.
has icd10 code: J15.7
code billability: billable
anatomical location: respiratory tract
has ICD10 name: Pneumonia due to Mycoplasma pneumoniae

Allergic contact dermatitis of external ear DP
type: Class
subclass of: contact dermatitis of external ear DP
has icd11 code: EG40.0
has ICD10 name: Allergic contact dermatitis of external ear
label: 外耳过敏性接触性皮炎 @zh

Other specified inflammatory DP of external ear
type: Class
subclass of: otitis externa DP
subclass of: Restriction
  on property: occurs in
  some values from: external ear
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: specified
subclass of: Restriction
  on property: has DP output
  some values from: inflammatory anatomical entity
has icd11 code: EG4Y
has icd11 code: 其他特指的外耳炎性疾患 @zh
has ICD10 name: Other specified inflammatory disorder of external ear

Irritant contact dermatitis of external ear DP
type: Class
subclass of: contact dermatitis of external ear DP
has icd11 code: EK02.10
has ICD10 name: Irritant contact dermatitis of external ear
label: 刺激物接触性外耳皮炎 @zh

Acute serous otitis media DP
type: Class
subclass of: Nonsuppurative otitis media DP
subclass of: Restriction
  on property: occurs in
  some values from: middle ear
subclass of: Restriction
  on property: has DP material quality
  some values from: acute
subclass of: Restriction
  on property: has DP material quality
  some values from: serous
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
definition editor: Eric Wan, Oliver He
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65.00
has gbt_14396 code: H65.000
has icd10 code: H65.00
code billability: Billable
has ICD10 name: Acute serous otitis media, unspecified ear
label: 急性浆液性中耳炎 @zh

other acute nonsuppurative otitis media DP
type: Class
subclass of: Nonsuppurative otitis media DP
subclass of: Restriction
  on property: occurs in
  some values from: middle ear
subclass of: Restriction
  on property: has DP material quality
  some values from: other
subclass of: Restriction
  on property: has DP material quality
  some values from: acute
subclass of: Restriction
  on property: has DP material quality
  some values from: nonsuppurative
subclass of: Restriction
  on property: has DP output
  some values from: otitis anatomical entity
definition editor: Oliver He, Eric Wan
definition source: https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65.1
has icd10 code: H65.1
code billability: Non-Billable
has ICD10 name: Other acute nonsuppurative otitis media
label: 急性非化脓性中耳炎，其他的 @zh

blue drum syndrome DP
type: Class
subclass of: syndrome DP
label: 蓝鼓膜综合征 @zh

serous
type: Class
subclass of: morphology
label: 浆液性 @zh

middle ear
type: Class
subclass of: ear

nonsuppurative
type: Class
subclass of: morphology
label: 非化脓性 @zh

New: Infective myositis, unspecified site
type: Class
subclass of: New: Infective myositis
definition: A disorder characterized by an infectious process involving the skeletal muscles.
definition editor: Jennifer Odalys Roman
definition source: https://www.sciencedirect.com/topics/medicine-and-dentistry/pyomyositis#:~:text=Pyomyositis%20is%20a%20pyogenic%20infection,contained%20by%20hypervascular%20connective%20tissue.
has icd10 code: M60.009
code billability: billable
anatomical location: UBERON:0014892
anatomical location: skeletal muscle organ
source: https://www.icd10data.com/ICD10CM/Codes/M00-M99/M60-M63/M60-/M60.009
has_related_synonym: Infective myositis

ready for release
type: NamedIndividual
has curation status: pending final vetting

pending final vetting
type: NamedIndividual

requires discussion
type: NamedIndividual
has curation status: pending final vetting

axiom holds for all times
type: NamedIndividual
definition: ## Elucidation This is used when the statement/axiom is assumed to hold true 'eternally' ## How to interpret (informal) First the "atemporal" FOL is derived from the OWL using the standard interpretation. This axiom is temporalized by embedding the axiom within a for-all-times quantified sentence. The t argument is added to all instantiation predicates and predicates that use this relation. ## Example Class: nucleus SubClassOf: part_of some cell forall t : forall n : instance_of(n,Nucleus,t) implies exists c : instance_of(c,Cell,t) part_of(n,c,t) ## Notes This interpretation is *not* the same as an at-all-times relation

bfo.owl
contributor: Leonard Jacuzzo
contributor: Janna Hastings
contributor: Barry Smith
comment: Please see the project site https://github.com/BFO-ontology/BFO, the bfo2 owl discussion group http://groups.google.com/group/bfo-owl-devel , the bfo2 discussion group http://groups.google.com/group/bfo-devel, the tracking google doc http://goo.gl/IlrEE, and the current version of the bfo2 reference http://purl.obolibrary.org/obo/bfo/dev/bfo2-reference.docx . This ontology is generated from a specification at https://github.com/BFO-ontology/BFO/tree/master/src/ontology/owl-group/specification/ and with the code that generates the OWL version in https://github.com/BFO-ontology/BFO/tree/master/src/tools/. A very early version of BFO version 2 in CLIF is at http://purl.obolibrary.org/obo/bfo/dev/bfo.clif
comment: The BSD license on the BFO project site refers to code used to build BFO.
contributor: David Osumi-Sutherland
contributor: Pierre Grenon
contributor: Werner Ceusters
contributor: Selja Seppälä
contributor: Jie Zheng
contributor: Thomas Bittner
contributor: Mathias Brochhausen
comment: This BFO 2.0 version represents a major update to BFO and is not strictly backwards compatible with BFO 1.1. The previous OWL version of BFO, version 1.1.1 will remain available at http://ifomis.org/bfo/1.1 and will no longer be updated. The BFO 2.0 OWL is a classes-only specification. The incorporation of core relations has been held over for a later version.
contributor: Mauricio Almeida
contributor: Melanie Courtot
contributor: Bjoern Peters
contributor: Yongqun "Oliver" He
contributor: James A. Overton
editor note: BFO 2 Reference: For both terms and relational expressions in BFO, we distinguish between primitive and defined. ‘Entity’ is an example of a primitive term. Primitive terms in a highest-level ontology such as BFO are terms that are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms.
contributor: Jonathan Bona
contributor: Holger Stenzhorn
contributor: Fabian Neuhaus
contributor: Randall Dipert
contributor: Stefan Schulz
contributor: Larry Hunter
license: http://creativecommons.org/licenses/by/4.0/
contributor: Chris Mungall
editor note: BFO 2 Reference: BFO does not claim to provide complete coverage of entities of all types. It seeks only to provide coverage of those entities studied by empirical science together with those entities which affect or are involved in human activities such as data processing and planning - coverage that is sufficiently broad to provide assistance to those engaged in building domain ontologies for purposes of data annotation.
contributor: Ron Rudnicki
contributor: Mark Ressler
contributor: Albert Goldfain
editor note: BFO 2 Reference: BFO’s treatment of continuants and occurrents - as also its treatment of regions, rests on a dichotomy between space and time, and on the view that there are two perspectives on reality - earlier called the ‘SNAP’ and ‘SPAN’ perspectives, both of which are essential to the non-reductionist representation of reality as we understand it from the best available science
contributor: Bill Duncan
contributor: Ludger Jansen
contributor: Alan Ruttenberg

OBO Relations Ontology
description: The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies.
license: https://creativecommons.org/publicdomain/zero/1.0/