ICDO: International Classification of Diseases Ontology Edison Ong Grace Whah Jennifer Roman Justin Song Ling Wan (Eric) Oliver He Virginia He 09-27-2021 1.0.77 Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification. Really of interest to developers only BFO OWL specification label Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2 Person:Alan Ruttenberg Really of interest to developers only BFO CLIF specification label editor preferred term The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English) PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> editor preferred term example of usage has curation status PERSON:Alan Ruttenberg PERSON:Bill Bug PERSON:Melanie Courtot OBI_0000281 has curation status definition The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition definition editor note An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. PERSON:Daniel Schober GROUP:OBI:<http://purl.obfoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note editor note editor note term editor Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115. PERSON:Daniel Schober GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition editor term editor alternative term definition source formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007 PERSON:Daniel Schober Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w GROUP:OBI:<http://purl.obolibrary.org/obo/obi> definition source definition source curator note An administrative note of use for a curator but of no use for a user PERSON:Alan Ruttenberg IAO:0000232 uberon curator_notes true curator_notes curator note curator note curator notes imported from expand expression to OBO foundry unique label elucidation has associated axiom(nl) has associated axiom(fol) has gbt_14396 code has icd11 code has_alternative_id in icd10 has icd10 code has icd9 code An annotation property that indicates whether the code is specific enough to be used as a billable medical code. Oliver He https://www.icd10data.com/ICD10CM/Codes/Rules/Billable_Specific_Codes The following 72,186 ICD-10-CM codes are billable/specific and can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code. Reference: https://www.icd10data.com/ICD10CM/Codes/Rules/Billable_Specific_Codes code billability An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context. temporal interpretation https://github.com/oborel/obo-relations/wiki/ROAndTime S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T. RO:0002174 uberon dubious_for_taxon true true dubious_for_taxon this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost dubious_for_taxon S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S RO:0002175 applicable for taxon uberon present_in_taxon true true present_in_taxon present_in_taxon An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL. logical macro assertion https://github.com/oborel/obo-relations/wiki/ShortcutRelations A logical macro assertion whose domain is an IRI for a property logical macro assertion on a property Used to annotate object properties to describe a logical meta-property or characteristic of the object property. logical macro assertion on an object property logical macro assertion on an annotation property relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y The general property hierarchy is: "directly P" SubPropertyOf "P" Transitive(P) Where we have an annotation assertion "directly P" "is direct form of" "P" If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q' Chris Mungall is direct form of relation p is the indirect form of relation q iff p is a subPropertyOf q, and there exists some p' such that p' is the direct form of q, p' o p' -> p, and forall x,y : x q y -> either (1) x p y or (2) x p' y Chris Mungall is indirect form of RO:0002604 quality is_opposite_of true true is_opposite_of is opposite of Used to annotate object properties representing a causal relationship where the value indicates a direction. Should be "+", "-" or "0" cjm 2018-03-13T23:59:29Z is directional form of cjm 2018-03-14T00:03:16Z is positive form of cjm 2018-03-14T00:03:24Z is negative form of part-of is homeomorphic for independent continuants. R is homemorphic for C iff (1) there exists some x,y such that x R y, and x and y instantiate C and (2) for all x, if x is an instance of C, and there exists some y some such that x R y, then it follows that y is an instance of C. cjm 2018-10-21T19:46:34Z R homeomorphic-for C expands to: C SubClassOf R only C. Additionally, for any class D that is disjoint with C, we can also expand to C DisjointWith R some D, D DisjointWith R some C. is homeomorphic for An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class. UBPROP:0000001 uberon external_definition true external_definition This annotation property may be replaced with an annotation property from an external ontology such as IAO external_definition A textual description of an axiom loss in this ontology compared to an external ontology. UBPROP:0000002 uberon axiom_lost_from_external_ontology true axiom_lost_from_external_ontology This annotation property may be replaced with an annotation property from an external ontology such as IAO axiom_lost_from_external_ontology Notes on the homology status of this class. UBPROP:0000003 uberon homology_notes true homology_notes This annotation property may be replaced with an annotation property from an external ontology such as IAO homology_notes UBPROP:0000006 uberon implements_design_pattern true implements_design_pattern implements_design_pattern Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'. UBPROP:0000007 uberon has_relational_adjective true has_relational_adjective has_relational_adjective Notes on the how instances of this class vary across species. UBPROP:0000008 uberon taxon_notes true taxon_notes taxon_notes Notes on the evolved function of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000009 uberon function_notes true function_notes function_notes Notes on the structure, composition or histology of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000010 uberon structure_notes true structure_notes structure_notes Notes on the ontogenic development of instances of this class. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000011 uberon development_notes true development_notes development_notes Notes on how similar or equivalent classes are represented in other ontologies. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000012 uberon external_ontology_notes true external_ontology_notes external_ontology_notes Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy. This annotation property may be replaced with an annotation property from an external ontology such as IAO UBPROP:0000013 uberon terminology_notes true terminology_notes terminology_notes FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term UBPROP:0000202 uberon fma_set_term true fma_set_term fma_set_term anatomical location has ICD10 name is part of uberon dc-contributor true dc-contributor contributor has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_namespace has_related_synonym in_subset shorthand is defined by uberon seeAlso true seeAlso see also uberon depicted_by true depicted_by depicted by is part of my brain is part of my body (continuant parthood, two material entities) my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. part_of part of http://www.obofoundry.org/ro/#OBO_REL:part_of has part my body has part my brain (continuant parthood, two material entities) my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity) this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. has_part has part realized in this disease is realized in this disease course this fragility is realized in this shattering this investigator role is realized in this investigation is realized by realized_in [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realized in realizes this disease course realizes this disease this investigation realizes this investigator role this shattering realizes this fragility to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003]) Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process realizes preceded by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by preceded by precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. precedes occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t occurs_in unfolds in unfolds_in Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in site of [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant contains process A disease process may occurs in the left side of ear. In this case, the domain is the disease process, and the range is the left side. An object property that represents a relation between a disease process (i.e., DP) and the lateral side of an anatomical entity where the disease process occurs. Eric Wan, Oliver He DP occurs in anatomical lateral side has syndrome has DP material quality caused by An object property that represents a relation between a disease process and a material entity where the disease process has the material entity as a typically abnormal material output. Eric Wan, Oliver He has DP output An object property that represents a relation between a process and a process profile where the process has the process profile. Oliver He has profile has process profile inheres in this fragility inheres in this vase this red color inheres in this apple a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence A dependent inheres in its bearer at all times for which the dependent exists. inheres_in inheres in bearer of this apple is bearer of this red color this vase is bearer of this fragility a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of bearer of participates in this blood clot participates in this blood coagulation this input material (or this output material) participates in this process this investigator participates in this investigation a relation between a continuant and a process, in which the continuant is somehow involved in the process participates_in participates in has participant this blood coagulation has participant this blood clot this investigation has participant this investigator this process has participant this input material (or this output material) a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant http://www.obofoundry.org/ro/#OBO_REL:has_participant has participant this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. has_function has function this apple has quality this red color a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. has_quality has quality this person has role this investigator role (more colloquially: this person has this role of investigator) a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. has_role has role a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence has disposition inverse of has disposition disposition of penicillin (CHEBI:17334) is allergic trigger for penicillin allergy (DOID:0060520) A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. is allergic trigger for A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. is autoimmune trigger for penicillin allergy (DOID:0060520) has allergic trigger penicillin (CHEBI:17334) A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. has allergic trigger A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. has autoimmune trigger x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2). David Osumi-Sutherland regulates in other organism A part of relation that applies only between occurents. occurent part of A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. dos 2017-05-24T09:30:46Z has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. dos 2017-05-24T09:31:01Z By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'. has negative regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. dos 2017-05-24T09:31:17Z By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'. has positive regulatory component activity dos 2017-05-24T09:36:08Z A has necessary component activity B if A and B are GO molecular functions (GO_0003674), A has_component B and B is necessary for A. For example, ATPase coupled transporter activity has necessary component ATPase activity; transcript factor activity has necessary component DNA binding activity. has necessary component activity dos 2017-05-24T09:44:33Z A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B. has component activity w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. dos 2017-05-24T09:49:21Z has component process A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function. dos 2017-07-19T17:30:36Z has ligand Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another. dos 2017-07-20T17:11:08Z transports dos 2017-09-17T13:52:24Z Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. directly regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. dos 2017-09-17T13:52:38Z directly negatively regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. dos 2017-09-17T13:52:47Z directly positively regulated by A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. dos 2017-09-22T14:14:36Z This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations. has effector activity David Osumi-Sutherland X ends_after Y iff: end(Y) before_or_simultaneous_with end(X) ends after David Osumi-Sutherland starts_at_end_of X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by David Osumi-Sutherland ends_at_start_of meets X immediately_precedes_Y iff: end(X) simultaneous_with start(Y) immediately precedes David Osumi-Sutherland io X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y)) starts during David Osumi-Sutherland d during X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y)) happens during David Osumi-Sutherland o overlaps X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y). ends during x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) overlaps a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones). a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b connected to https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern The M8 connects Glasgow and Edinburgh a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones). c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system. connects https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure. Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure drains w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity. For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit. has component A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype). Chris Mungall has phenotype inverse of has phenotype Chris Mungall phenotype of process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit Chris Mungall David Hill Tanya Berardini GO Regulation precludes parthood; the regulatory process may not be within the regulated process. regulates (processual) false regulates Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2. Chris Mungall negatively regulates (process to process) negatively regulates Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2. Chris Mungall positively regulates (process to process) positively regulates 'human p53 protein' SubClassOf some ('has prototype' some ('participates in' some 'DNA repair')) heart SubClassOf 'has prototype' some ('participates in' some 'blood circulation') x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation. Experimental. In future there may be a formalization in which this relation is treated as a shortcut to some modal logic axiom. We may decide to obsolete this and adopt a more specific evolutionary relationship (e.g. evolved from) TODO: add homeomorphy axiom This property can be used to make weaker forms of certain relations by chaining an additional property. For example, we may say: retina SubClassOf has_prototype some 'detection of light'. i.e. every retina is related to a prototypical retina instance which is detecting some light. Note that this is very similar to 'capable of', but this relation affords a wider flexibility. E.g. we can make a relation between continuants. Chris Mungall has prototype mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974) osteoclast SubClassOf 'capable of' some 'bone resorption' A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. Chris Mungall has function realized in For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)". RO_0000053 some (RO_0000054 only ?Y) capable of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. Chris Mungall has function in RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y)) capable of part of 'heart development' has active participant some Shh protein x has participant y if and only if x realizes some active role that inheres in y This may be obsoleted and replaced by the original 'has agent' relation Chris Mungall has agent obsolete has active participant true Chris Mungall Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends. https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit?pli=1 A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations. temporally related to Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall started by starts with x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. Chris Mungall finished by ends with p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. Chris Mungall consumes has input p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p. Chris Mungall produces has output A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event. ExO:0000001 has exposure receptor A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event. ExO:0000000 has exposure stressor A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor ExO:0000055 has exposure route A broad relationship between an exposure event or process and the course takes from the source to the target. http://purl.obolibrary.org/obo/ExO_0000004 has exposure transport path Any relationship between an exposure event or process and any other entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving exposure events or processes. related via exposure to c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432) has biological role c has-application-role r iff c has-role r and r is an application role (CHEBI:33232) has application role c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086) has chemical role A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision. c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. acts upstream of A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway. c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. affects acts upstream of or within p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint. Chris Mungall results_in_developmental_progression_of results in developmental progression of every flower development (GO:0009908) results in development of some flower (PO:0009046) p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state. Chris Mungall http://www.geneontology.org/GO.doc.development.shtml results_in_development_of results in development of an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists. every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062) Chris Mungall GOC:mtg_berkeley_2013 results_in_formation_of results in formation of an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape. tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723) The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state. Chris Mungall GOC:mtg_berkeley_2013 results_in_morphogenesis_of results in morphogenesis of an annotation of gene X to cell maturation with results_in_maturation_of CL:0000057 (fibroblast) means that the fibroblast is mature at the end of the process bone maturation (GO:0070977) results_in_maturation_of bone (UBERON:0001474) The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity. Chris Mungall GOC:mtg_berkeley_2013 results_in_maturation_of results in maturation of foramen ovale closure SubClassOf results in disappearance of foramen ovale Chris Mungall May be merged into parent relation results_in_disappearance_of results in disappearance of every mullerian duct regression (GO:0001880) results in regression of some mullerian duct (UBERON:0003890) Chris Mungall May be merged into parent relation results in developmental regression of Inverse of 'is substance that treats' cjm is treated by substance cjm holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y causally upstream of, positive effect cjm holds between x and y if and only if x is causally upstream of y and the progression of x decreases the frequency, rate or extent of y causally upstream of, negative effect A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event. Austin Meier Chris Mungall Marie Angelique Laporte cjm 2017-06-05T17:35:04Z has exposure stimulus Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c. Chris Mungall regulates localization of transports or maintains localization of q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. Because part_of is transitive, inheres in is a sub-relation of inheres in part of Chris Mungall inheres in part of an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast. The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity Chris Mungall GOC:mtg_berkeley_2013 results_in_acquisition_of_features_of results in acquisition of features of A mereological relationship or a topological relationship Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships mereotopologically related to A relationship that holds between entities participating in some developmental process (GO:0032502) Chris Mungall Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development developmentally related to ATP citrate lyase (ACL) in Arabidopsis: it is a heterooctamer, composed of two types of subunits, ACLA and ACLB in a A(4)B(4) stoichiometry. Neither of the subunits expressed alone give ACL activity, but co-expression results in ACL activity. Both subunits contribute_to the ATP citrate lyase activity. Subunits of nuclear RNA polymerases: none of the individual subunits have RNA polymerase activity, yet all of these subunits contribute_to DNA-dependent RNA polymerase activity. eIF2: has three subunits (alpha, beta, gamma); one binds GTP; one binds RNA; the whole complex binds the ribosome (all three subunits are required for ribosome binding). So one subunit is annotated to GTP binding and one to RNA binding without qualifiers, and all three stand in the contributes_to relationship to "ribosome binding". And all three are part_of an eIF2 complex We would like to say if and only if exists c', p' c part_of c' and c' capable_of p and c capable_of p' and p' part_of p then c contributes_to p However, this is not possible in OWL. We instead make this relation a sub-relation of the two chains, which gives us the inference in the one direction. Chris Mungall http://www.geneontology.org/GO.annotation.conventions.shtml#contributes_to In the context of the Gene Ontology, contributes_to may be used only with classes from the molecular function ontology. contributes to a particular instances of akt-2 enables some instance of protein kinase activity Chris Mungall catalyzes executes has is catalyzing is executing This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time. enables A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. Chris Mungall This is a grouping relation that collects relations used for the purpose of connecting structure and function functionally related to this relation holds between c and p when c is part of some c', and c' is capable of p. Chris Mungall false part of structure that is capable of c involved_in p if and only if c enables some process p', and p' is part of p Chris Mungall actively involved in enables part of involved in inverse of enables Chris Mungall enabled by inverse of regulates Chris Mungall regulated by (processual) regulated by inverse of negatively regulates Chris Mungall negatively regulated by inverse of positively regulates Chris Mungall positively regulated by A relationship that holds via some process of localization Chris Mungall Do not use this relation directly. It is a grouping relation. related via localization to Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s. Chris Mungall imports 'pollen tube growth' results_in growth_of some 'pollen tube' Chris Mungall results in growth of Chris Mungall exports inverse of has input Chris Mungall input of inverse of has output Chris Mungall output of Chris Mungall formed as result of A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity. Chris Mungall results in structural organization of 'protein catabolic process' SubClassOf has_direct_input some protein p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p. Chris Mungall directly consumes This is likely to be obsoleted. A candidate replacement would be a new relation 'has bound input' or 'has substrate' has direct input translation SubClassOf has_direct_output some protein p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. Chris Mungall directly produces obsolete has direct output true inverse of upstream of Chris Mungall causally downstream of Chris Mungall immediately causally downstream of p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q Chris Mungall directly positively regulates directly activates (process to process) directly activates p indirectly activates q if and only if p is upstream of q and there is a chain of directly activates relationships connecting p and q, where the chain is of length greater than one. Chris Mungall indirectly positively regulates indirectly activates Chris Mungall directly negatively regulates directly inhibits (process to process) directly inhibits Chris Mungall indirectly negatively regulates indirectly inhibits This relation groups causal relations between material entities and causal relations between processes This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types. Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causally related to p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain Chris Mungall causally upstream of p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. Chris Mungall immediately causally upstream of p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c This is currently called 'directly provides input for' to be consistent with our terminology where we use 'direct' whenever two occurrents succeed one another directly. We may relabel this simply 'provides input for', as directness is implicit Chris Mungall directly provides input for (process to process) directly provides input for transitive form of directly_provides_input_for Chris Mungall This is a grouping relation that should probably not be used in annotation. Consider instead the child relation 'directly provides input for' (which may later be relabeled simply to 'provides input for') transitively provides input for (process to process) transitively provides input for p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2 Chris Mungall influences (processual) affects causally upstream of or within inverse of causally upstream of or within Chris Mungall causally downstream of or within c involved in regulation of p if c is involved in some p' and p' regulates some p Chris Mungall involved in regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p Chris Mungall involved in positive regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p Chris Mungall involved in negative regulation of c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p OWL does not allow defining object properties via a Union Chris Mungall involved in or reguates involved in or involved in regulation of A relationship that holds between two entities in which the processes executed by the two entities are causally connected. Considering relabeling as 'pairwise interacts with' This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact. Chris Mungall Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules. in pairwise interaction with interacts with http://purl.obolibrary.org/obo/MI_0914 https://github.com/oborel/obo-relations/wiki/InteractionRelations An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. Chris Mungall binds molecularly binds with molecularly interacts with http://purl.obolibrary.org/obo/MI_0915 The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. Chris Mungall Vasundra Touré molecularly controls directly regulates activity of The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. Chris Mungall Vasundra Touré directly inhibits molecularly decreases activity of directly negatively regulates activity of The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. Chris Mungall Vasundra Touré directly activates molecularly increases activity of directly positively regulates activity of Chris Mungall Experimental: relation used for defining interaction relations. An interaction relation holds when there is an interaction event with two partners. In a directional interaction, one partner is deemed the subject, the other the target partner in Chris Mungall Experimental: relation used for defining interaction relations; the meaning of s 'subject participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the subject is the predator. We can imagine a reciprocal prey-predatory process with subject and object reversed. subject participant in Chris Mungall Experimental: relation used for defining interaction relations; the meaning of s 'target participant in' p is determined by the type of p, where p must be a directional interaction process. For example, in a predator-prey interaction process the target is the prey. We can imagine a reciprocal prey-predatory process with subject and object reversed. target participant in A relationship between a material entity and a process where the material entity has some causal role that influences the process causal agent in process p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between processes Chris Mungall depends on 'lysine biosynthetic process via diaminopimelate' SubClassOf has_intermediate some diaminopimelate p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c Chris Mungall has intermediate product has intermediate The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch Chris Mungall Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. causal relation between entities A coral reef environment is determined by a particular coral reef s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future Chris Mungall determined by (system to material entity) Chris Mungall Pier Buttigieg determined by inverse of determined by Chris Mungall determines (material entity to system) determines s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. Chris Mungall determined by part of p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded. Chris Mungall results in ending of Chris Mungall causally influenced by (entity-centric) causally influenced by Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c Chris Mungall results in movement of The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). Chris Mungall Vasundra Touré causally influences (entity-centric) causally influences Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. Chris Mungall directly regulates (processual) directly regulates gland SubClassOf 'has part structure that is capable of' some 'secretion by cell' s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p Chris Mungall has part structure that is capable of p 'results in closure of' c if and only if p is a developmental process and p results in a state of c changing from open to closed. results in closure of p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p results in breakdown of results in synthesis of results in assembly of p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released. results in catabolism of results in disassembly of results in remodeling of p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c results in organization of A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. Chris Mungall causal relation between material entity and a process pyrethroid -> growth Holds between c and p if and only if c is capable of some activity a, and a regulates p. capable of regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. capable of negatively regulating renin -> arteriolar smooth muscle contraction Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. capable of positively regulating pazopanib -> pathological angiogenesis Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p. treats The entity c may be a molecular entity with a drug role, or it could be some other entity used in a therapeutic context, such as a hyperbaric chamber. capable of inhibiting or preventing pathological process benzene -> cancer [CHEBI] Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p. causes disease capable of upregulating or causing pathological process c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d. treats is substance that treats Inverse of 'causal agent in process' process has causal agent Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2. directly positively regulates (process to process) directly positively regulates Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2. directly negatively regulates (process to process) directly negatively regulates Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA. Vasundra Touré represses expression of Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA. Vasundra Touré increases expression of The genetic variant 'NM_007294.3(BRCA1):c.110C>A (p.Thr37Lys)' casues or contributes to the disease 'familial breast-ovarian cancer'. An environment of exposure to arsenic causes or contributes to the phenotype of patchy skin hyperpigmentation, and the disease 'skin cancer'. A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition. Note that relationships of phenotypes to organisms/strains that bear them, or diseases they are manifest in, should continue to use RO:0002200 ! 'has phenotype' and RO:0002201 ! 'phenotype of'. Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions. causes or contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition. causes condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition. contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual. contributes to expressivity of condition contributes to severity of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population. contributes to penetrance of condition contributes to frequency of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition. is preventative for condition Genetic variations can span any level of granularity from a full genome or genotype to an individual gene or sequence alteration. These variations can be represented at the physical level (DNA/RNA macromolecules or their parts, as in the ChEBI ontology and Molecular Sequence Ontology) or at the abstract level (generically dependent continuant sequence features that are carried by these macromolecules, as in the Sequence Ontology and Genotype Ontology). The causal relations in this hierarchy can be used in linking either physical or abstract genetic variations to phenotypes or diseases they cause or contribute to. Environmental exposures include those imposed by natural environments, experimentally applied conditions, or clinical interventions. ameliorates condition A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition. exacerbates condition A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity. condition ameliorated by A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity. condition exacerbated by Do not use this relation directly. It is intended as a grouping for a more specific relations cjm 2017-11-05T02:38:20Z condition has genetic basis in cjm 2017-11-05T02:45:20Z has material basis in gain of function germline mutation in cjm 2017-11-05T02:45:37Z has material basis in loss of function germline mutation in cjm 2017-11-05T02:45:54Z has material basis in germline mutation in cjm 2017-11-05T02:46:07Z has material basis in somatic mutation in cjm 2017-11-05T02:46:26Z has major susceptibility factor cjm 2017-11-05T02:46:57Z has partial material basis in germline mutation in p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. cjm 2018-12-13T11:26:17Z has primary input or output p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. cjm 2018-12-13T11:26:32Z has primary output p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. cjm 2018-12-13T11:26:56Z has primary input Do not use this relation directly. It is intended as a grouping for a more specific relations cjm 2017-11-05T02:53:08Z is genetic basis for condition Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. cjm 2017-11-05T02:55:51Z is causal gain of function germline mutation of in Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. cjm 2017-11-05T02:56:06Z is causal loss of function germline mutation of in Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. cjm 2017-11-05T02:56:40Z is causal germline mutation in Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]. cjm 2017-11-05T02:57:07Z is causal somatic mutation in Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition and that is necessary but not sufficient to develop the condition[modified from orphanet]. cjm 2017-11-05T02:57:43Z is causal susceptibility factor for Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]. cjm 2017-11-05T02:58:43Z is causal germline mutation partially giving rise to cjm 2017-11-05T03:20:01Z realizable has basis in cjm 2017-11-05T03:20:29Z is basis for realizable cjm 2017-11-05T03:26:47Z disease has basis in A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function. disease has basis in dysfunction of (disease to anatomical structure) cjm 2017-11-05T03:29:32Z disease has basis in dysfunction of A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process. disease has basis in disruption of (disease to process) cjm 2017-11-05T03:37:52Z disease has basis in disruption of A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature. cjm 2017-11-05T03:46:07Z disease has basis in feature Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all of which have a disease as the subject. cjm 2017-11-05T03:50:54Z causal relationship with disease as subject A relationship between a disease and a process where the disease process disrupts the execution of the process. disease causes disruption of (disease to process) cjm 2017-11-05T03:51:09Z disease causes disruption of disease causes dysfunction of (disease to anatomical entity) cjm 2017-11-05T03:58:20Z disease causes dysfunction of A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. cjm 2017-12-26T19:45:49Z realized in response to stimulus A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. cjm 2017-12-26T19:58:44Z disease arises from structure cjm 2018-01-26T23:49:30Z acts upstream of or within, positive effect cjm 2018-01-26T23:49:51Z acts upstream of or within, negative effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive cjm 2018-01-26T23:53:14Z acts upstream of, positive effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative cjm 2018-01-26T23:53:22Z acts upstream of, negative effect cjm 2018-03-13T23:55:05Z causally upstream of or within, negative effect cjm 2018-03-13T23:55:19Z causally upstream of or within, positive effect A drought sensitivity trait that inheres in a whole plant is realized in a systemic response process in response to exposure to drought conditions. An inflammatory disease that is realized in response to an inflammatory process occurring in the gut (which is itself the realization of a process realized in response to harmful stimuli in the mucosal lining of th gut) Environmental polymorphism in butterflies: These butterflies have a 'responsivity to day length trait' that is realized in response to the duration of the day, and is realized in developmental processes that lead to increased or decreased pigmentation in the adult morph. r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. Austin Meier Chris Mungall David Osumi-Sutherland Marie Angelique Laporte triggered by process realized in response to https://docs.google.com/document/d/1KWhZxVBhIPkV6_daHta0h6UyHbjY2eIrnON1WIRGgdY/edit The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. Vasundra Touré regulates activity of The entity A has an activity that regulates the quantity or abundance or concentration of the entity B. Vasundra Touré regulates quantity of The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B. Vasundra Touré indirectly regulates activity of The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B. Vasundra Touré decreases by repression quantity of The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B. Vasundra Touré increases by expression quantity of The entity A has an activity that directly positively regulates the quantity of B. Vasundra Touré directly positively regulates quantity of The entity A has an activity that directly negatively regulates the quantity of B. Vasundra Touré directly negatively regulates quantity of The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B. Vasundra Touré indirectly activates indirectly positively regulates activity of AKT1 destabilizes quantity of FOXO (interaction from Signor database: SIGNOR-252844) An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it. Vasundra Touré destabilizes quantity of AKT1 stabilizes quantity of XIAP (interaction from Signor database: SIGNOR-119488) An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it. Vasundra Touré stabilizes quantity of The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B. Vasundra Touré indirectly inhibits indirectly negatively regulates activity of The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B. Vasundra Touré directly regulates quantity of The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B. Vasundra Touré indirectly regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B. Vasundra Touré indirectly negatively regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B. Vasundra Touré indirectly positively regulates quantity of This relation groups relations between diseases and any other kind of entity. Do not use this relation directly. It is intended as a grouping for a diverse set of relations, in which the subject or object is a disease. cjm 2018-09-26T00:00:32Z disease relationship p has anatomical participant c iff p has participant c, and c is an anatomical entity cjm 2018-09-26T01:08:58Z has anatomical participant Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison. TODO: Add homeomorphy axiom ECO:0000041 SO:similar_to sameness similar to correspondence resemblance in similarity relationship with entity Entity Julius Caesar Verdi’s Requiem the Second World War your body mass index BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81 Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001]) entity continuant Continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240 Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002]) if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001]) if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002]) if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002]) (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] continuant occurrent Occurrent An entity that has temporal parts and that happens, unfolds or develops through time. BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players. Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process. Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame. An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002]) Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001]) b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001]) (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] occurrent ic IndependentContinuant a chair a heart a leg a molecule a spatial region an atom an orchestra. an organism the bottom right portion of a human torso the interior of your mouth A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001]) For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002]) (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] independent continuant s-region SpatialRegion BFO 2 Reference: Spatial regions do not participate in processes. Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional. A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001]) All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001]) (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] spatial region t-region TemporalRegion Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001]) All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001]) Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002]) (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002] (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001] (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001] temporal region 2d-s-region TwoDimensionalSpatialRegion an infinitely thin plane in space. the surface of a sphere-shaped part of space A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001]) (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] two-dimensional spatial region st-region SpatiotemporalRegion the spatiotemporal region occupied by a human life the spatiotemporal region occupied by a process of cellular meiosis. the spatiotemporal region occupied by the development of a cancer tumor A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001]) All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001]) Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001]) Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001]) Every spatiotemporal region occupies_spatiotemporal_region itself. Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002]) (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002] (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001] (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001] (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001] (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001] spatiotemporal region process Process a process of cell-division, \ a beating of the heart a process of meiosis a process of sleeping the course of a disease the flight of a bird the life of an organism your process of aging. An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war) (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] process disposition Disposition an atom of element X has the disposition to decay to an atom of element Y certain people have a predisposition to colon cancer children are innately disposed to categorize objects in certain ways. the cell wall is disposed to filter chemicals in endocytosis and exocytosis BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type. b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002]) If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002]) (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] disposition realizable RealizableEntity the disposition of this piece of metal to conduct electricity. the disposition of your blood to coagulate the function of your reproductive organs the role of being a doctor the role of this boundary to delineate where Utah and Colorado meet A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002]) All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002]) (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] realizable entity 0d-s-region ZeroDimensionalSpatialRegion A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001]) (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001] zero-dimensional spatial region quality Quality the ambient temperature of this portion of air the color of a tomato the length of the circumference of your waist the mass of this piece of gold. the shape of your nose the shape of your nostril a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001]) If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001]) (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] quality sdc SpecificallyDependentContinuant Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key of one-sided specifically dependent continuants: the mass of this tomato of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates. the disposition of this fish to decay the function of this heart: to pump blood the mutual dependence of proton donors and acceptors in chemical reactions [79 the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction the pink color of a medium rare piece of grilled filet mignon at its center the role of being a doctor the shape of this hole. the smell of this portion of mozzarella A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc. (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] specifically dependent continuant role Role John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. the priest role the role of a boundary to demarcate two neighboring administrative territories the role of a building in serving as a military target the role of a stone in marking a property boundary the role of subject in a clinical trial the student role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives. b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001]) (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] role fiat-object-part FiatObjectPart or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29 the FMA:regional parts of an intact human body. the Western hemisphere of the Earth the division of the brain into regions the division of the planet into hemispheres the dorsal and ventral surfaces of the body the upper and lower lobes of the left lung BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004]) (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004] fiat object part 1d-s-region OneDimensionalSpatialRegion an edge of a cube-shaped portion of space. A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001]) (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001] one-dimensional spatial region 3d-s-region ThreeDimensionalSpatialRegion a cube-shaped region of space a sphere-shaped region of space, A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001]) (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001] three-dimensional spatial region site Site Manhattan Canyon) a hole in the interior of a portion of cheese a rabbit hole an air traffic control region defined in the airspace above an airport the Grand Canyon the Piazza San Marco the cockpit of an aircraft the hold of a ship the interior of a kangaroo pouch the interior of the trunk of your car the interior of your bedroom the interior of your office the interior of your refrigerator the lumen of your gut your left nostril (a fiat part – the opening – of your left nasal cavity) b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002]) (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002] site gdc GenericallyDependentContinuant The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity. the pdf file on your laptop, the pdf file that is a copy thereof on my laptop the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule. A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] generically dependent continuant function Function the function of a hammer to drive in nails the function of a heart pacemaker to regulate the beating of a heart through electricity the function of amylase in saliva to break down starch into sugar BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc. A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001]) (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] function 1d-t-region OneDimensionalTemporalRegion the temporal region during which a process occurs. BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks). A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001]) (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001] one-dimensional temporal region material MaterialEntity a flame a forest fire a human being a hurricane a photon a puff of smoke a sea wave a tornado an aggregate of human beings. an energy wave an epidemic the undetached arm of a human being An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60 BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity. BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here. A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002]) Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002]) every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002]) (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] material entity cf-boundary ContinuantFiatBoundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions. BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29 Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions. Every continuant fiat boundary is located at some spatial region at every time at which it exists (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001] continuant fiat boundary immaterial ImmaterialEntity BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10 immaterial entity 1d-cf-boundary OneDimensionalContinuantFiatBoundary The Equator all geopolitical boundaries all lines of latitude and longitude the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin. the median sulcus of your tongue a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001]) (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001] one-dimensional continuant fiat boundary process-profile ProcessProfile On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance. The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on. b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005]) (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005] (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002] process profile r-quality RelationalQuality John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married. a marriage bond, an instance of requited love, an obligation between one person and another. b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001] relational quality 2d-cf-boundary TwoDimensionalContinuantFiatBoundary a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001]) (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001] two-dimensional continuant fiat boundary 0d-cf-boundary ZeroDimensionalContinuantFiatBoundary the geographic North Pole the point of origin of some spatial coordinate system. the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona. a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001]) (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001] zero-dimensional continuant fiat boundary 0d-t-region ZeroDimensionalTemporalRegion a temporal region that is occupied by a process boundary right now the moment at which a child is born the moment at which a finger is detached in an industrial accident the moment of death. temporal instant. A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001]) (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001] zero-dimensional temporal region history History A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001]) history anatomical entity connected anatomical structure material anatomical entity immaterial anatomical entity biological entity biological_process Disease process is the progression disease in an individual over time. The process begins with the appropriate exposure to or accumulation of factors sufficient for the disease process to begin in a susceptible host. For an infectious disease, the exposure is a microorganism. For cancer, the exposure may be a factor that initiates the process, such as asbestos fibers or components in tobacco smoke (for lung cancer), or one that promotes the process, such as estrogen (for endometrial cancer). https://www.cdc.gov/ophss/csels/dsepd/ss1978/lesson1/section9.html disorder disease process 病程 https://www.icd10data.com/ICD10CM/Codes/H60-H95 H60-H95 Diseases of the ear and mastoid process diseases of the ear or mastoid process ear or mastoid disease process 耳或乳突疾病 atresia DP 闭锁 infectious diseases of external ear infectious DP of external ear 外耳感染性疾病 Eric Wan, Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H60-H62 H60-H95 Diseases of external ear external ear DP 外耳疾病病程 ossification DP 骨化 cellulitis cellulitis DP 蜂窝织炎病程 H60.900 EG4Z H60 otitis externa otitis externa DP 外耳炎 infectious 感染性 is a major abnormality in the shape of a body part or organ compared to the normal shape of that part. deformity DP 畸形 畸形 cholesteatoma DP 胆脂瘤 H61.102 pinna fistula pinna fistula DP 耳郭瘘 noninfectious inflammation of external ear DP 外耳非感染性炎症病程 pathological anatomical entity DP A disease process that has the outcome of the formation of a cyst cyst DP 囊肿 inflammatory anatomical entity that is located in ear otitis anatomical entity 耳炎体 fistula DP 瘘 granuloma granuloma DP 肉芽肿病程 noninflammatory disorders noninflammatory DP 非炎症性疾病病程 tumor DP 肿物 scar DP 瘢痕病程 noninflammatory disorders of the external ear noninflammatory DP of the external ear 非炎症性外耳疾患 A hernia occurs when an organ pushes through an opening in the muscle or tissue that holds it in place. For example, the intestines may break through a weakened area in the abdominal wall. Hernias are most common in the abdomen, but they can also appear in the upper thigh, belly button, and groin areas. Most hernias aren’t immediately life-threatening, but they don’t go away on their own. Sometimes they can require surgery to prevent potentially dangerous complications. https://www.healthline.com/health/hernia hernia DP 疝 obstructive 阻塞性 otitis DP 耳炎病程 stenosis DP 狭窄 pseudocyst DP 假性囊肿 infectious disease 感染 infectious DP 感染性疾病过程 immune system DP 免疫系统疾病过程 developed after birth : not congenital or hereditary https://www.merriam-webster.com/dictionary/acquired 获得性 acquired 后天性 other 其他的 specified 特指的 unspecified 非特指的 diseases claasified elsewhere 可分类于他处的疾病 necrotic otitis externa LHPM 坏死性外耳炎 LHPM syndrome DP an immune system disease process that undergoes an inflammation process and has output of an inflammatory anatomical entity. https://www.webmd.com/arthritis/about-inflammation 炎 inflammation DP 炎症病程 Aspergillus 曲霉菌 Candida 念珠菌 chemical 化学性 necrosis DP 坏死 severe necrosis DP 严重坏死 diffuse 弥漫性 hemorrhagic 出血性 water 水 fungus 真菌 Perichondritis is inflammation of the perichondrium, a layer of connective tissue which surrounds cartilage Oliver He, Eric Wan https://en.wikipedia.org/wiki/Perichondritis https://www.icd10data.com/ICD10CM/Index/P/Perichondritis perichondritis DP 软骨膜炎 chondrodermatitis chondrodermatitis DP 软骨皮炎 nodularis 结节性 noninfectious 非感染性 skin disease skin DP 皮肤疾病 疖 abscess DP 脓肿病程 seborrhoeic 脂溢性 noninflammatory 非炎症性 cauliflower like 菜花样的 environment entity 环境因素 keloid DP 瘢痕瘤病程 骨疣 exostosis DP 外生骨疣 disease of the circulatory system I00-I99 Diseases of the circulatory system disease (process) of the circulatory system https://en.wikipedia.org/wiki/Hypertension I10-I15.9 Hypertensive diseases hypertensive disease process hematoma 血肿 角化病 角化症 keratosis DP 角化病程 is a closed sac, having a distinct membrane and division compared with the nearby tissue. Hence, it is a cluster of cells that has grouped together to form a sac (not unlike the manner in which water molecules group together, forming a bubble); however, the distinguishing aspect of a cyst is that the cells forming the "shell" of such a sac are distinctly abnormal (in both appearance and behaviour) when compared with all surrounding cells for that given location. It may contain air, fluids, or semi-solid material. A collection of pus is called an abscess, not a cyst. Once formed, sometimes a cyst may resolve on its own. When a cyst fails to resolve, it may need to be removed surgically, but that would depend upon its type and location. cyst 囊肿 actinic 光化性 impacted 栓塞性的 chemical entity 化学物质 bacterial infectious via bacterium 细菌性 parasitic 寄生性 viral 病毒性 I15.9 is a billable ICD code used to specify a diagnosis of secondary hypertension, unspecified. A 'billable code' is detailed enough to be used to specify a medical diagnosis. Virginia He, Oliver He https://icd.codes/icd10cm/I159#:~:text=a%20principal%20diagnosis.-,I15.,diagnosis%20of%20secondary%20hypertension%2C%20unspecified. I15.9 Non-Billable Secondary hypertension, unspecified unspecified secondary hypertension DP A hypertensive disease that shows up with persistently elevated high blood pressure in the arteries, and has no identifiable cause. It does not include those hypertensive diseases complicating pregnancy, childbirth and the puerperium. Note that the essential hypertension affects 95% of hypertensive patients. Justin Song, Oliver He, Virginia He essential hypertension primary hypertension https://en.wikipedia.org/wiki/Essential_hypertension https://www.healthline.com/health/essential-hypertension https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I10-/I10 https://www.unboundmedicine.com/icd/view/ICD-10-CM/895449/all/I10___Essential__primary__hypertension I10 Billable Essential (primary) hypertension essential primary hypertension DP eczematoid 湿疹样 is a pathological anatomical structures transformed from pathological continuant entities. On carcinomas and other pathological entities ,Comp Funct Genomics. 2005;6(7-8):379-87. doi: 10.1002/cfg.497.. https://www.ncbi.nlm.nih.gov/pubmed/18629199 pathological anatomical entity erysipelas DP 丹毒病程 is the abnormal exit of tissue or an organ, such as the bowel, through the wall of the cavity in which it normally resides.[1] Hernias come in a number of different types.[6] Most commonly they involve the abdomen, specifically the groin.[6] Groin hernias are most common of the inguinal type but may also be femoral.[1] Other hernias include hiatus, incisional, and umbilical hernias.[6] Symptoms are present in about 66% of people with groin hernias.[1] This may include pain or discomfort especially with coughing, exercise, or going to the bathroom.[1] Often it gets worse throughout the day and improves when lying down.[1] A bulging area may occur that becomes larger when bearing down.[1] Groin hernias occur more often on the right than left side.[1] The main concern is strangulation, where the blood supply to part of the bowel is blocked.[1] This usually produces severe pain and tenderness of the area.[1] Hiatus or hiatal hernias often result in heartburn but may also cause chest pain or pain with eating.[ hernia 疝 is a form of cell injury which results in the premature death of cells in living tissue by autolysis. https://en.wikipedia.org/wiki/Necrosis necrotic 坏死性 pinna defect after burn PKPM 烧伤后耳廓缺损 PKPM is an irreversible condition that occurs when the external portion of the ear is hit and develops a blood clot or other collection of fluid under the perichondrium. This separates the cartilage from the overlying perichondrium that supplies its nutrients, causing it to die and resulting in the formation of fibrous tissue in the overlying skin. As a result, the outer ear becomes permanently swollen and deformed, resembling a cauliflower. cauliflower ear 菜花耳 abnormality in the shape of a body part or organ defect 畸形 缺损 deformity entity 畸形体 Obsolete class noninfectious inflammation DP 非感染性炎症病程 sunlight 日光 阳光 mycotic 真菌性 dermatitis dermatitis DP 皮炎病程 枪伤 acquired from gun shoot 枪伤后 defect 缺损 is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and/or mastoid process. Cholesteatomas are not cancerous as the name may suggest, but can cause significant problems because of their erosive and expansile properties. This can result in the destruction of the bones of the middle ear (ossicles), as well as growth through the base of the skull into the brain. They often become infected and can result in chronically draining ears. Treatment almost always consists of surgical removal. cholesteatoma entity 胆脂瘤体 is an area of fibrous tissue that replaces normal skin after an injury. Scars result from the biological process of wound repair in the skin, as well as in other organs and tissues of the body. Thus, scarring is a natural part of the healing process. With the exception of very minor lesions, every wound (e.g., after accident, disease, or surgery) results in some degree of scarring. An exception to this are animals with complete regeneration, which regrow tissue without scar formation. 瘢痕 scar entity 瘢痕体 Keloid, also known as keloid disorder and keloidal scar,[1] is the formation of a type of scar which, depending on its maturity, is composed mainly of either type III (early) or type I (late) collagen. It is a result of an overgrowth of granulation tissue (collagen type 3) at the site of a healed skin injury which is then slowly replaced by collagen type 1. Keloids are firm, rubbery lesions or shiny, fibrous nodules, and can vary from pink to the color of the person's skin or red to dark brown in color. A keloid scar is benign and not contagious, but sometimes accompanied by severe itchiness, pain,[2] and changes in texture. In severe cases, it can affect movement of skin. Keloid scars are seen 15 times more frequently in people of sub-Saharan African descent than in people of European descent. keloid entity 瘢痕瘤体 is a structure formed during inflammation that is found in many diseases. It is a collection of immune cells known as macrophages.[1] Granulomas form when the immune system attempts to wall off substances it perceives as foreign but is unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as keratin and suture fragments. 肉芽肿 granuloma 肉芽肿体 TEST: cellulitis of external ear 外耳蜂窝织炎 TSEM http://www.icd9data.com/2015/Volume1/390-459/401-405/401/401.0.htm https://www.webmd.com/hypertension-high-blood-pressure/guide/what-is-malignant-hypertension#1 401.0 This term exists in ICD-9 but not ICD-10 malignant essential hypertension DP is an abnormal connection between two hollow spaces (technically, two epithelialized surfaces), such as blood vessels, intestines, or other hollow organs. Fistulas are usually caused by injury or surgery, but they can also result from an infection or inflammation.[3] Fistulas are generally a disease condition, but they may be surgically created for therapeutic reasons. fistula 瘘 Pseudocysts are like cysts, but lack epithelial or endothelial cells. Initial management consists of general supportive care. Symptoms and complications caused by pseudocysts require surgery. Computed tomography (CT) scans are used for initial imaging of cysts, and endoscopic ultrasounds are used in differentiating between cysts and pseudocysts. Endoscopic drainage is a popular and effective method of treating pseudocysts. This is not to be confused with the so-called "pseudocystic appearance", mainly radiographically, of other lesions, such as Stafne static bone cyst and aneurysmal bone cyst[1] of the jaws. pseudocyst 假性囊肿 is a type of abnormal and excessive growth, called neoplasia, of tissue. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and it persists growing abnormally, even if the original trigger is removed.[1][2][3] This abnormal growth usually (but not always) forms a mass.[4] When it forms a mass, it may be called a tumor. neoplasm tumor 肿物 inflammatory 炎症性 is a growth of keratin on the skin or on mucous membranes stemming from keratinocytes, the prominent cell type in the epidermis. https://en.wikipedia.org/wiki/Keratosis 角质化体 keratosis entity 角化体 is a condition in which an orifice or passage in the body is (usually abnormally) closed or absent. Examples of atresia include: Biliary atresia, a condition in newborns in which the common bile duct between the liver and the small intestine is blocked or absent. https://en.wikipedia.org/wiki/Atresia 闭锁 atresia entity 闭锁体 An exostosis, also known as bone spur, is the formation of new bone on the surface of a bone.[1] Exostoses can cause chronic pain ranging from mild to debilitatingly severe, depending on the shape, size, and location of the lesion. It is most commonly found in places like the ribs, where small bone growths form, but sometimes larger growths can grow on places like the ankles, knees, shoulders, elbows and hips. Very rarely are they on the skull. 骨疣 exostosis 外生骨疣 401.1 This term exists in ICD-9 but not ICD-10 benign essential hypertension DP inflammatory anatomical entity that is located in a cellulite cellulitis anatomical entity 蜂窝织炎体 abnormal narrowed structure or organ 狭窄 stenosis 狭窄体 is an acute infection typically with a skin rash, usually on any of the legs and toes, face, arms, and fingers.[1] It is an infection of the upper dermis and superficial lymphatics, usually caused by beta-hemolytic group A Streptococcus bacteria on scratches or otherwise infected areas.[2] Erysipelas is more superficial than cellulitis, and is typically more raised and demarcated.[1] The term is from Greek ἐρυσίπελας, meaning "red skin". erysipelas 丹毒 H60.000 AA00 H60.0 abscess of external ear 疖 痈 abscess of external ear DP 外耳脓肿病程 bony substance ossification entity 骨化体 a physical pathological anatomic entity that is a result of an inflammation process Eric Wan, Oliver He 感染 炎 炎症 炎症体 inflammatory anatomical entity 发炎体 is a collection of pus that has built up within the tissue of the body.[1] Signs and symptoms of abscesses include redness, pain, warmth, and swelling.[1] The swelling may feel fluid-filled when pressed.[1] The area of redness often extends beyond the swelling.[6] Carbuncles and boils are types of abscess that often involve hair follicles, with carbuncles being larger. https://en.wikipedia.org/wiki/Abscess abscess 脓肿 is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus aureus or Streptococcus pyogenes.[1] The presence of a carbuncle is a sign that the immune system is active and fighting the infection.[2] The infection is contagious and may spread to other areas of the body, or other people; those living in the same residence may develop carbuncles at the same time.[3] In the early 21st century, infection involving methicillin-resistant staphylococcus aureus (MRSA) has become more common. https://en.wikipedia.org/wiki/Carbuncle carbuncle 痈 is a deep folliculitis, infection of the hair follicle. It is most commonly caused by infection by the bacterium Staphylococcus aureus, resulting in a painful swollen area on the skin caused by an accumulation of pus and dead tissue.[1] Boils which are expanded are basically pus-filled nodules.[2][verification needed] Individual boils clustered together are called carbuncles.[3] Most human infections are caused by coagulase-positive S. aureus strains, notable for the bacteria's ability to produce coagulase, an enzyme that can clot blood. Almost any organ system can be infected by S. aureus. boil furuncle 疖 mycosis mycosis DP 真菌病 a necrotic object necrosis entity 坏死体 external acoustic meatus atresia after burn JYPM 烧伤后外耳道闭锁 JYPM TEST: cholesteatoma of external auditory canal 外耳道胆脂瘤 inflammatory anatomical entity that is located in the skin of a cartilage tissue chondrodermatitis anatomical entity 软骨皮炎体 inflammatiory anatomical entity in the membrane of cartilage tissue perichondritis anatomical entity 软骨膜炎体 acquired from injury 因外伤导致的 after burn 烧伤后 acquired from burn 烧伤所致 砍伤后 acquired from knife 刀伤后 infectious disorder in pinna PKDM 耳廓感染 PKDM dermis and subcutaneous tissues 皮及皮下组织 external ear furuncle PKPM 外耳道疖 PKPM inflammatory anatomical entity that is located in skin dermatitis anatomical entity 皮炎体 granuloma in pinna PKPM 耳廓肉芽肿 PKPM H60.002 external ear carbuncle external ear carbuncle DP 外耳痈病程 H60.001 external ear furuncle external ear furuncle DP 外耳疖病程 infectious via virus malignant disease profile belign disease profile A hypertensive disease that is caused by an identifiable underlying primary cause inessential hypertension https://en.wikipedia.org/wiki/Secondary_hypertension https://www.unboundmedicine.com/icd/view/ICD-10-CM/864037/all/I15___Secondary_hypertension I15 Non-Billable Secondary hypertension secondary hypertension DP J00-J99 Diseases of the respiratory system disease (process) in the respiratory system J09-J18 Influenza and pneumonia pneumonia due to pathogen Inflammation of the lung that is caused by viral infection; causes air sacs in lungs to fill up with fluid. Virginia He https://www.healthline.com/health/pneumonia J12.9 Billable Viral pneumonia, unspecified viral pneumonia influenza pneumonia an infection of your lungs caused by certain bacteria. Virginia He https://www.webmd.com/lung/bacterial-pneumonia#:~:text=Bacterial%20pneumonia%20is%20an%20infection,throat%20without%20causing%20any%20trouble. J15 Non-billable Bacterial pneumonia, not elsewhere classified bacterial pneumonia an infection that inflames the air sacs in one or both lungs. Caused by Streptococcus pneumoniae bacteria https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204 J13 Billable Pneumonia due to Streptococcus pneumoniae pneumonia due to Streptococcus pneumoniae U07.1 Billable COVID-19, virus identified COVID-19 pneumonia a mild to severe respiratory illness that is caused by a coronavirus Oliver He, Virginia He https://www.merriam-webster.com/dictionary/COVID-19 https://www.who.int/classifications/icd/COVID-19-coding-icd10.pdf?ua=1 U07.2 COVID-19, virus not identified COVID-19, virus not identified clinically-epidemiologically diagnosied COVID-19 high blood pressure after a surgical procedure Virginia He, Oliver He https://en.wikipedia.org/wiki/Hypertension https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.3 I97.3 Billable postprocedural hypertension postprocedural hypertension DP developed after birth : not congenital or hereditary disease primary A disease profile that does not have a known secondary cause Virginia He, Oliver He essential disease profile primary disease profile A disease profile that is caused by another medical condition Virginia He, Oliver He secondary disease profile disease process profile disease profile Oliver He, Eric Wang, Virginia He acute disease profile Oliver He, Eric Wang, Virginia He chronic disease profile a common sickness combined with a lung infection caused by an unspecified pathogen. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.0 J11.0 Non-billable Influenza due to unidentified influenza virus with pneumonia influenza due to unidentified influenza virus with pneumonia pneumonia attacks the respiratory system caused by SARS-CoV-2 Virginia He, Justin Song https://www.healthline.com/health/pneumonia J12.81 Billable Pneumonia due to SARS-associated coronavirus pneumonia due to SARS-associated coronavirus Heart conditions caused by high blood pressure Virginia He https://www.healthline.com/health/hypertensive-heart-disease#:~:text=Hypertensive%20heart%20disease%20refers%20to,artery%20disease%2C%20and%20other%20conditions https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I11-/I11.9 I11.9 Billable Hypertensive heart disease without heart failure hypertensive heart disease process without heart failure pneumonia attacks the respiratory system. Contagious and hard to treat. Virginia He, Justin Song https://www.healthline.com/health/pneumonia J12.8 Non-billable other viral pneumonia other viral pneumonia J09-J18 Influenza and pneumonia influenza due to pathogen Also called coronary artery disease, describes heart problems caused by narrowed arteries that supply blood to the heart. https://www.google.com/search?q=ischemic+heart+diseases&oq=Ischemic+heart+diseases&aqs=chrome.0.0j69i59l2j0l4j69i61.516j0j7&sourceid=chrome&ie=UTF-8 I20-I25 Ischemic heart diseases ischemic heart DP a highly contagious viral infection of the respiratory passages causing fever and severe aching, often occuring in epidemics. Virginia He https://www.icd10data.com/ICD10CM/Codes?J00-J99/J09-J18/J10-/J10.0 J10.0 Non-billable Influenza due to other identified influenza virus with pneumonia influenza due other identified influenza virus with pneumonia acute or chronic inflammation of the renal tubules and interstitium. Acute interstitial nephritis is commonly caused by allergic reactions to drugs, but infection or systemic disease may also precipitate the disease. Virginia He, Justin Song https://www.amboss.com/us/knowledge/Tubulointerstitial_diseases#:~:text=Tubulointerstitial%20diseases%20are%20characterized%20by,may%20also%20precipitate%20the%20disease. https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16 N10-N16 Renal tubulo-interstitial diseases renal tubulo-interstitial disease processes A common viral infection that can be deadly, especially in high-risk groups. Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.1 J11.1 Billable Influenza due to unidentified influenza virus with other respiratory manisfestations Influenza due to unidentified influenza virus with other manisfestations heart problems caused by narrowed heart arteries. When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to heart attack. Virginia He https://www.ncbi.nlm.nih.gov/books/NBK209964/ I25 Non-billable Chronic ischemic heart disease chronic ischemic heart DP heart problems caused by narrowed heart arteries. When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to heart attack. Virginia He, Justin Song https://www.ncbi.nlm.nih.gov/books/NBK209964/ I25.1 Non-billable Atherosclerotic heart disease of native coronary artery atherosclerotic heart DP of native coronary artery Oliver He, Eric Wang, Virginia He ischemic disease profile A highly contagious, common viral infection of the respiratory passages causing fever and severe aching Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.8 J11.8 Non-billable Influenza due to unidentified influenza virus with other respiratory manisfestations Influenza due to unidentified influenza virus with other respiratory manisfestations lung inflammation caused by bacterial infection, in which air sacs fill with pus Virginia He https://www.healthline.com/health/pneumonia J15.2 Non-billable Pneumonia due to staphylococcus pneumonia due to staphylococcus Oliver He, Eric Wang, Virginia He atherosclerotic disease profile An inflammatory attack of the pharynx and nassal cavities. Minor and is a common contagious throat disease. Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J00-/J00 J00 Billable Acute nasopharyngitis [common cold] acute nasopharyngitis (common cold) Inflammation of the pharynx, which is in the back of the throat. Commonly referred to as "sore throat" Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J00-J06/J02-/J02.9 J02.9 Billable Acute pharyngitis, unspecified acute pharyngitis, unspecified upper respiratory system is infected and parts will become inflamed or damaged. Virginia He https://www.healthline.com/health/acute-upper-respiratory-infection#What-is-acute-upper-respiratory-infection? J06.9 Billable Acute upper respiratory infection, unspecified acute upper respiratory infection, unspecified pneumonia caused by bacteria Virginia He, Justin Song https://www.healthline.com/health/pneumonia J15.6 Billable Pneumonia due to other aerobic Gram-negative bacteria pneumonia due to other aerobic gram-negative bacteria pneumonia caused by bacteria Virginia He, Justin Song https://www.healthline.com/health/pneumonia J15.8 Billable Pneumonia due to other specified bacteria pneumonia due to other specified bacteria inflammation of the lung that is caused by bacterial infections Virginia He, Justin Song https://www.healthline.com/health/pneumonia J15.9 Billable unspecified bacterial pneumonia unspecified bacterial pneumonia bacterial pneumonia caused by other viral diseases Virginia He https://www.healthline.com/health/pneumonia J17.1 pneumonia in viral diseases classified elsewhere pneumonia in viral diseases classified elsewhere pneumonia caused by other diseases Virginia He https://www.healthline.com/health/pneumonia J17.8 pneumonia in other diseases classified elsewhere pneumonia in other diseases classified elsewhere Thickening and loss of elasticity of the coronary arteries, leading to progressive arterial insufficiency (coronary disease). Virginia He https://wexnermedical.osu.edu/heart-vascular/conditions-treatments/atherosclerosis I25.10 Non-billable Atherosclerotic heart disease of native coronary artery Atherosclerotic heart disease of native coronary artery without angina pectoris a lung infection that inflames and infects the aveoli Virginia He, Justin Song https://www.healthline.com/health/bronchopneumonia#:~:text=Bronchopneumonia%20is%20a%20type%20of,can%20be%20mild%20or%20severe J18.0 Billable bronchopneumonia, unspecified organism bronchopneumonia Documented history of previous myocardial infarction, a sudden and sometimes fatal occurrence of coronary thrombosis, typically resulting in the death of part of a heart muscle. Also known as heart attack. https://www.heart.org/en/health-topics/heart-attack/about-heart-attacks Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I25-/I25.2 I25.2 Billable Old myocardial infarction old myocardial infarction DP a form of pneumonia characterized by inflammatory exudate within the intra-alveolar space Virginia He, Justin Song en.wikipedia.org/wiki/Lobar_pneumonia https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J18-/J18.1 J18.1 Billable Lobar pneumonia, unspecified organism lobar pneumonia A lung infection caused by an unspecified pathogen Virginia He, Justin Song https://www.healthline.com/health/pneumonia J18.8 Billable Other pneumonia, unspecified organism other pneumonia An infection of one or both lungs Virginia He, Justin Song https://www.healthline.com/health/pneumonia J18.9 Billable pneumonia, unspecified organism pneumonia, unspecified organism lower respiratoy tract infection that causes reversible bronchia inflammation Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20.9 J20.9 Billable Acute bronchitis, unspecified acute bronchitis contagious infection of upper respiratory tract https://www.healthline.com/health/acute-upper-respiratory-infection J00-J06 Acute upper respiratory infections acute upper respiratory infections contagious infection of lower respiratory tract J20-J22 Other acute lower respiratory infections other acute lower respiratory infections acute infection that affects the lower respiratory tract. Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J22-/J22 J22 Billable unspecified acute lower respiratory infection unspecified acute lower respiratory tract infection chronic infection of lower respiratory tract J40-J47 chronic lower respiratory diseases chronic lower respiratory diseases a chronic pulmonary disease that obstructs bloodlflow Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.2 J43.2 Billable centrilobular emphysema centrilobular emphysema a chronic inflammatory lung disease that causes obstructed airflow from the lungs Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44 J44 Non-billable Other chronic obstructive pulmonsry disease other chronic obstructive pulmonary disease a chronic inflammatory lung disease that causes obstructed airflow from the lungs Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.0 J44.0 Billable Chronic obstructive pulmonary disease with (acute) lower respiratory infection chronic obstructive pulmonary disease with acute lower respiratory infection a chronic inflammatory lung disease that causes airway inflammation and reduced air flow from exacerbations Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.1 J44.1 Billable Chronic obstructive pulmonary disease with (acute) lower respiratory infection chronic obstructive pulmonary disease with acute exacerbation a chronic inflammatory lung disease that causes obstructed airflow from the lungs Virginia He https://medlineplus.gov/ency/article/000091.htm J44.8 other specified chronic obstructive pulmonary disease other specified chronic obstructive pulmonary disease a chronic inflammatory lung disease that causes permanent damage to the lungs, making it hard to breathe Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J44-/J44.9 J44.9 Billable chronic obstructive pulmonary disease, unspecified chronic obstructive pulmonary disease, unspecified Oliver He, Eric Wang, Virginia He myocardial disease profile a chronic disease in which the bronchial airways in the lungs become narrowed and swollen, making it difficult to breathe Virginia He https://www.healthline.com/health/asthma J45.9 Non-billable other and unspecified asthma asthma Bronchial airways in the lungs become narrowed and swollen, making it hard to breathe Virginia He, Justin Song https://www.healthline.com/health/asthma J45.909 Billable unspecified asthma, uncomplicated uncomplicated asthma a condition where the bronchial tubes of the lungs are permanently damaged, widened, and thickened Virginia He https://www.healthline.com/health/bronchiectasis J47 Non-billable Bronchiectasis bronchiectasis conditions of the lng caused by outside agents Virginia He J60-J70 Lung diseases due to external agents lung disease processes due to external agents Virginia He https://www.healthline.com/health/pneumonitis J69.0 Billable Inflammation of the lung tissue; noninfectious causes of lung inflammation Pneumonitis due to inhalation of food and vomit pneumonitis due to inhalation of food and vomit respiratory diseases affecting the interstitum, a fluid-filled space between a structural barrier (ie cell wall, skin) and internal structures (ie organs, muscles). Virginia He J80-J84 Other respiratory diseases principally affecting the interstitum other respiratory diseases affecting the interstitum fluids fill up the lung's air sacs, causing the lung to not function properly Virginia He, Justin Song https://www.healthline.com/health/acute-respiratory-distress-syndrome J80 Billable Acute respiratory distress syndrome acute respiratory distress syndrome extravascular accumulation of fluid in the pulmonary tissue and air sacs Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J81-/J81 J81 Non-billable Pulmonary edema pulmonary edema extravascular accumulation of fluid in the pulmonary tissue and air sacs Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J84-/J84.1 J84.1 Non-billable Other interstitial pulmonary diseases with fibrosis other interstitial pulmonary diseases with fibrosis diseases that inflame or scar the lungs Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J80-J84/J84-/J84.9 J84.9 Billable Interstitial pulmonary disease, unspecified interstitial pulmonary disease, unspecified diseases affecting the pleura, a membrane that lines the thorax Virginia He https://www.merriam-webster.com/dictionary/pleura J90-J94 Other diseases of the pleura other diseases of the pleura increased amounts of fluid in pleural cavity Virginia He, Justin Song https://www.healthline.com/health/pleural-effusion J90 Billable Pleural effusion, not elsewhere classified pleural effusion, not elsewhere classified increased amounts of fluid between the thin layers of tissue lining the lung and wall of the chest cavity Virginia He https://www.healthline.com/health/pleural-effusion J91 Non-billable Pleural effusion, not elsewhere classified pleural effusion in conditions classified elsewhere https://www.uofmhealth.org/health-library/tx4090abc the heart's ability to pump blood is decreased because the left ventricle is weak. This is caused by a lack of blood supply to the heart muscle caused by coronary artery disease and heart attacks. Virginia He I25.5 Billable Ischemic cardiomyopathy ischemic cardiomyopathy DP diseases affecting the respiratory system Virginia He https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99 J96-J99 Other diseases of the respiratory system other diseases of the respiratory system occurs when fluid builds up in air sacs of lungs Virginia He, Oliver He https://www.healthline.com/health/acute-respiratory-failure J96.0 Non-billable acute respiratory failure acute respiratory failure acute respiratory failure, unsure if it is hypoxemic (not enough oxygen, normal CO2 levels) or hypercapnic (too much CO2, oxygen normal or too low) Virginia He, Justin Song https://www.healthline.com/health/acute-respiratory-failure J96.00 Billable acute respiratory failure, unspecified whether with hypoxia or hypercapnia acute respiratory failure, unspecified whether with hypoxia or hypercapnia acute respiratory failure where a portion of the body is hypoxemic (not enough oxygen, normal CO2 levels) Virginia He, Justin Song https://www.healthline.com/health/acute-respiratory-failure J96.01 Billable acute respiratory failure with hypoxia acute respiratory failure with hypoxia respiratory system is unable to function properly; is long-term (chronic) Virginia He, Justin Song https://www.healthline.com/health/chronic-respiratory-failure J96.1 Non-billable chronic respiratory failure chronic respiratory failure respiratory system is unable to function properly; is long-term (chronic) or short-term (acute) Virginia He, Justin Song https://www.healthline.com/health/chronic-respiratory-failure J96.2 Non-billable acute and chronic respiratory failure acute and chronic respiratory failure respiratory system is unable to function properly; is long-term (chronic) or short-term (acute); can be with hypoxia (too little oxygen) or hypercapnia (too much CO2, normal/low oxygen) Virginia He, Justin Song https://www.healthline.com/health/chronic-respiratory-failure J96.20 Billable acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia acute and chronic respiratory failure, unspecified whether with hypoxia or hypercapnia respiratory system has been attacked, used to specify symptoms Virginia He, Justin Song https://icd.codes/icd10cm/J9600#:~:text=J96.,whether%20with%20hypoxia%20or%20hypercapnia J96.9 Non-billable Respiratory failure, unspecified respiratory failure, unspecified respiratory system has been damaged, unspecified whether there is too much CO2 (hypercapnia) or too little oxygen (hypoxmia) in the body Virginia He, Justin Song https://medlineplus.gov/respiratoryfailure.html J96.90 Billable Respiratory failure, unspecified whether with hypoxia or hypercapnia respiratory failure, unspecified whether with hypoxmia or hypercapnia when the alveoli (helps exchange oxygen in air for CO2), don't fill with air Virginia He https://www.healthline.com/health/atelectasis J98.11 Billable Atelectasis atelectasis disorders affecting the lungs, ie asthma, COPD, influenza, etc. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.4 J98.4 Billable Other disorders of the lung other disorders of the lung conditions affecting the respiratory system Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.8 J98.8 Billable Other specified respiratory disorders other sepcified respiratory disorders https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/symptoms-causes/syc-20350569 when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff — sometimes restricting blood flow to your organs and tissues. Virginia He I25.8 Billable Ischemic cardiomyopathy coronary atherosclerosis DP due to lipid rich plaque Ischemic heart disease is the term given to heart problems caused by narrowed heart (coronary) arteries that supply blood to the heart muscle. It's most often it is caused by buildup of plaque, called atherosclerosis. https://www.mayoclinic.org/diseases-conditions/coronary-artery-disease/symptoms-causes/syc-20350613 Virginia He I25.9 Billable Chronic ischemic heart disease, unspecified chronic ischemic heart DP, unspecified the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance or high blood pressure in the lungs. Virginia He https://en.wikipedia.org/wiki/Pulmonary_heart_disease#:~:text=Pulmonary%20heart%20disease%2C%20also%20known,blood%20pressure%20in%20the%20lungs. I26-I28 Section Pulmonary heart disease and diseases of pulmonary circulation pulmonary heart DP and disease processes of pulmonary circulation A blockage of an artery in the lungs by a foreign substance https://en.wikipedia.org/wiki/Pulmonary_embolism Virginia He, Justin Song I26.9 Non-billable pulmonary embolism without acute cor pulmonale pulmonary embolism DP without acute cor pulmonale A disorder characterized by cessation of the pumping function of the heart. Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I46- I46 Non-billable Cardiac arrest cardiac arrest DP A disorder characterized by cessation of the pumping function of the heart. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I46-/I46.9 I46.9 Billable Cardiac arrest, cause unspecified cardiac arrest, cause unspecified abnormally fast heartbeat. It's a broad term that includes many forms of heart rhythm problems Virginia He https://www.mayoclinic.org/diseases-conditions/supraventricular-tachycardia/symptoms-causes/syc-20355243#:~:text=Supraventricular%20tachycardia%20(SVT)%2C%20also,the%20atria%20or%20AV%20node. I47.1 Billable Supraventricular tachycardia supraventricular tachycardia In atrial fibrillation, the atria beat irregularly. In atrial flutter, the atria beat regularly, but faster than usual and more often than the ventricles Virginia He https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/ask-the-experts/atrial-flutter#:~:text=Normally%2C%20the%20top%20chambers%20(atria,to%20every%20one%20ventricular%20beat. I48 Non-billable Atrial fibrillation and flutter atrial fibrillation and flutter DP Oliver He, Eric Wang, Virginia He atrial disease profile Oliver He, Eric Wang, Virginia He supraventricular disease profile a rapid, erratic heart rate begins suddenly and then stops on its own within 7 days Virginia He https://www.medicalnewstoday.com/articles/316281 I48.0 Billable paroxysmal atrial fibrillation paroxysmal atrial fibrillation DP refers to AF that occurs for longer than 7 days and ends spontaneously or with treatment Virginia He, Justin Song http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/cardiology/atrial-fibrillation/#:~:text=1,or%20that%20is%20not%20treated. I48.1 Non-billable Persistent atrial fibrillation persistent atrial fibrillation DP a type of heart arrhythmia that causes the top chambers of your heart, the atria, to quiver and beat irregularly. Lasts over a week. Virginia He https://www.healthline.com/health/atrial-fibrillation/chronic#:~:text=Overview,lasting%20longer%20than%20one%20week. I48.2 Non-billable chronic atrial fibrillation chronic atrial fibrillation DP A problem with the rate or rhythm of your heartbeat. It means that your heart beats too quickly, too slowly, or with an irregular pattern Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I49-/I49.9 I49.9 Billable Cardiac arrhythmia, unspecified cardiac arrhythmia DP, unspecified very fast electrical discharge patterns that make the atria contract very rapidly, causing them to contract faster and less efficiently than normal. Virginia He https://www.merckmanuals.com/home/heart-and-blood-vessel-disorders/abnormal-heart-rhythms/atrial-fibrillation-and-atrial-flutter#:~:text=Atrial%20fibrillation%20and%20atrial%20flutter%20are%20very%20fast%20electrical%20discharge,and%20less%20efficiently%20than%20normal. I48.9 Non-billable Unspecified atrial fibrillation and atrial flutter unspecified atrial fibrillation and atrial flutter DP a common electrocardiographic (ECG) abnormality seen in patients whose normal cardiac conduction down both anterior and posterior left fascicles of the His-Purkinje system is compromised. Virginia He https://www.ncbi.nlm.nih.gov/books/NBK482167/#:~:text=D%2C%20Hicks%20GJ.-,Introduction,His%2DPurkinje%20system%20is%20compromised. I44.7 Billable Left bundle-branch block left bundle-branch block DP, unspecified Electrical impulses that cause your heart to beat originate in the upper right chamber of the heart and travel to the lower chambers. In bundle branch block, the pathway that these impulses travel on is delayed or blocked. Virginia He https://www.mayoclinic.org/diseases-conditions/bundle-branch-block/symptoms-causes/syc-20370514#:~:text=Bundle%20branch%20block-,Bundle%20branch%20block,on%20is%20delayed%20or%20blocked. I44 Non-billable Atrioventricular and left bundle-branch block atrioventricular and left bundle-branch block DP A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure. Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50- I50 Non-billable heart failure heart failure DP Oliver He, Eric Wang, Virginia He atrioventricular disease profile A disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure. Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50- I50.9 Billable heart failure, unspecified heart failure, unspecified An episode of acute neurological dysfunction presumed to be caused by ischemia or hemorrhage, persisting ≥24 hours or until death Virginia He, Justin Song https://www.ahajournals.org/doi/pdf/10.1161/str.0b013e318296aeca#:~:text=Definition%20of%20stroke%2C%20not%20otherwise,Page%204 I64 Stroke, not specified as haemorrhage or infarction stroke DP, not specified as haemorrhage or infarction residual effects or conditions produced after the acute phase of a stroke Virginia He, Justin Song http://bok.ahima.org/doc?oid=301069#.XxsDs5NKg6U I69.4 Sequelae of stroke, not specified as haemorrhage or infarction sequelae DP of stroke, not specified as haemorrhage or infarction When plaque (fatty deposits) clogs your arteries Virginia He https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/atherosclerosis#:~:text=Atherosclerosis%20and%20cholesterol,of%20the%20blood%20vessel%20thickens. I70.2 Non-billable Atherosclerosis of native arteries of extremities with gangrene atherosclerosis DP of native arteries of extremities with gangrene A thickening and loss of elasticity of the walls of arteries that occurs with formation of atherosclerotic plaques within the arterial intima. Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I70-I79/I70- I70 Non-billable Atherosclerosis atherosclerosis DP Diseases of the lymphatic system, a network of tissues and organs. Virginia He https://medlineplus.gov/lymphaticdiseases.html I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified disease processes of veins, lymphatic vessels and lymph nodes a condition that occurs when the venous wall and/or valves in the leg veins are not working effectively, making it difficult for blood to return to the heart from the legs. Virginia He https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi#:~:text=Chronic%20venous%20insufficiency%20(CVI)%20is,this%20pooling%20is%20called%20stasis. I87.2 Billable Venous insufficiency (chronic) (peripheral) venous insufficiency DP A disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment. Virginia He https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I95- I95 Non-billable Hypotension hypotension DP A significant drop in blood pressure after assuming a standing position Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I95-/I95.1 I95.1 Billable Orthostatic hypotension orthostatic hypotension DP A decrease in systemic blood pressure below accepted low values (pressures less than 90/60 are recognized as hypotensive) Virginia He, Justin Song https://www.ncbi.nlm.nih.gov/books/NBK499961/#:~:text=Hypotension%20is%20a%20decrease%20in,because%20it%20is%20typically%20asymptomatic. I95.8 Non-billable Other hypotension other hypotension DP A decrease in systemic blood pressure below accepted low values (pressures less than 90/60 are recognized as hypotensive) Virginia He, Justin Song https://www.ncbi.nlm.nih.gov/books/NBK499961/#:~:text=Hypotension%20is%20a%20decrease%20in,because%20it%20is%20typically%20asymptomatic. I95.9 Billable Hypotension, unspecified hypotension DP, unspecified any cardiac complications occurring in the postanesthetic care unit (PACU) Virginia He https://accessanesthesiology.mhmedical.com/content.aspx?bookid=974&sectionid=61589392 I97.89 Billable Non-billable Other postprocedural complications and disorders of the circulatory system, not elsewhere classified Other postprocedural complications and disorders of the circulatory system Virginia He enzymes that confer resistance to most beta-lactam antibiotics, including penicillins, cephalosporins, and the monobactam aztreonam https://www.uptodate.com/contents/extended-spectrum-beta-lactamases#:~:text=Extended%2Dspectrum%20beta%2Dlactamases%20(,cephalosporins%2C%20and%20the%20monobactam%20aztreonam.&text=The%20first%20plasmid%2Dmediated%20beta,in%20Greece%20in%20the%201960s. U82.2 Extended spectrum betalactamase (ESBL) resistance antibiotic resistance bacterial disease (process) a type of common virus that infects humans, typically leading to an upper respiratory infection Virginia He, Justin Song https://www.medicinenet.com/script/main/art.asp?articlekey=22789 B34.2 Billable Coronavirus infection, unspecified coronavirus infection DP, unspecified Genitourinary disease involves disorders of the genital and urinary organs. These organs are involved in reproduction and urination disease of the genitourinary system https://www.encyclopedia.com/education/encyclopedias-almanacs-transcripts-and-maps/genitourinary-disease#:~:text=Genitourinary%20disease%20involves%20disorders%20of,and%20the%20uterus%20in%20females. N00-N99 Diseases of the genitourinary system disease (process) of the genitourinary system Erysipelas is a relatively common bacterial infection of the superficial layer of the skin (upper dermis), extending to the superficial lymphatic vessels within the skin, characterized by a raised, well-defined, tender, bright red rash, typically on the face or legs, but which can occur anywhere on the skin. It is a form of cellulitis and is potentially serious. Erysipelas is usually caused by the bacteria Streptococcus pyogenes. Grace Whah, Oliver He St. Anthony's fire A46 https://en.wikipedia.org/wiki/Erysipelas https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A46-/A46 Erysipelas a bacterial infection causing inflammation of the kidneys and is one of the most common diseases of the kidney. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N10-/N10 https://www.ncbi.nlm.nih.gov/books/NBK519537/#:~:text=Acute%20pyelonephritis%20is%20a%20bacterial,kidneys%20and%20their%20collecting%20systems. N10 Billable Acute pyelonephritis acute pyelonephritis DP A disorder characterized by the acute loss of renal function Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17 N17 Non-Billable Acute kidney failure acute kidney failure DP A disorder characterized by the acute loss of renal function Virginia He https://myhealth.alberta.ca/Health/Pages/conditions.aspx?hwid=aa106178&lang=en-ca#:~:text=Kidney%20problems%20can%20develop%20suddenly,reversible%20than%20chronic%20kidney%20failure. N17-N19.9 Acute kidney failure and chronic kidney disease acute kidney failure or chronic kidney DP Acute kidney failure resulting from destruction of epithelial cells of the kidney tubules. Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17.0 N17.0 Billable Acute kidney failure with tubular necrosis acute kidney failure with tubular necrosis DP kidney is no longer able to filter blood. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N17-/N17.8 https://www.mayoclinic.org/diseases-conditions/kidney-failure/symptoms-causes/syc-20369048 N17.8 Billable other acute kidney failure https://icdlist.com/icd-10/N17.8 N17.8 is a billable code used to specify a medical diagnosis of other acute kidney failure. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code N17.8 might also be used to specify conditions or terms like acute renal failure due to ischemia or ischemic nephropathy or post-renal renal failure. other acute kidney failure DP kidney(s)'s functions are compromised. This will be a short term problem Virginia He, Justin Song https://www.mayoclinic.org/diseases-conditions/kidney-failure/symptoms-causes/syc-20369048 N17.9 Billable other acute kidney failure acute kidney failure DP, unspecified A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18- N18 Non-Billable Chronic kidney disease chronic kidney disease DP A disease that causes moderate kidney damage. A person is more likely to develop complications of kidney disease such as high blood pressure, anemia, and/or early bone disease. Virginia He https://www.niddk.nih.gov/health-information/kidney-disease/anemia N18.3 Billable Chronic kidney disease, stage 3 (moderate) chronic kidney DP, stage 3 kidneys are moderately or severely damaged and are not working as they should. Stage 4 kidney disease should be taken very seriously – it is the last stage before kidney failure. Virginia He, Justin Song https://www.kidneyfund.org/kidney-disease/chronic-kidney-disease-ckd/stages-of-chronic-kidney-disease/#:~:text=Stage%204%20CKD%20means%20you,last%20stage%20before%20kidney%20failure. N18.4 Billable Chronic kidney disease, stage 4 (severe) chronic kidney DP, stage 4 Chronic, irreversible renal failure. Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.5 N18.5 Billable Chronic kidney disease, stage 5 chronic kidney DP, stage 5 Chronic, irreversible renal failure. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.6 N18.6 Billable End stage renal disease end stage renal DP A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N18-/N18.9 N18.9 Billable Chronic kidney disease, unspecified chronic kidney DP unspecified A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of renal insufficiency. Virginia He https://www.icd10data.com/ICD10CM/Codes/N00-N99/N17-N19/N19-/N19 N19 Billable Unspecified kidney failure unspecified kidney failure DP the unirary tract is infected and cannot function properly Virginia He, Justin Song https://www.mayoclinic.org/diseases-conditions/urinary-tract-infection/symptoms-causes/syc-20353447 N39.0 Billable urinary tract infection, site not specified urinary tract infection DP A benign (noncancerous) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53/N40-/N40 N40 Non-billable Benign prostatic hyperplasia benign prostatic hyperplasia DP when your prostate gland becomes suddenly inflamed Virginia He https://www.healthline.com/health/prostatitis-bacterial-acute#:~:text=Acute%20prostatitis%20happens%20when%20your,this%20fluid%20into%20your%20urethra. N41.0 Billable Acute prostatitis acute prostatitis DP Diseases that affect the male reproductive and genital organs https://www.icd10data.com/ICD10CM/Codes/N00-N99/N40-N53 N40-N53 Diseases of male genital organs DP of male genital organs Anemia caused by low iron intake, inefficient iron absorption in the gastrointestinal tract, or chronic blood loss. Virginia He https://www.icd10data.com/ICD10CM/Codes/D50-D89/D50-D53/D50- D50 Non-billable Iron deficiency anemia iron deficiency anemia DP caused by a shortage of iron in your body. Virginia He https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360#:~:text=Iron%20deficiency%20anemia.,hemoglobin%20for%20red%20blood%20cells. D50.8 Billable Other iron deficiency anemias other iron deficiency anemia DP Iron deficiency anemia is a common type of anemia — a condition in which blood lacks adequate healthy red blood cells. Virginia He, Justin Song https://www.mayoclinic.org/diseases-conditions/iron-deficiency-anemia/symptoms-causes/syc-20355034#:~:text=Iron%20deficiency%20anemia%20is%20a,is%20due%20to%20insufficient%20iron. D50.9 Billable Iron deficiency anemia, unspecified iron deficiency anemia, unspecified It occurs when you inherit copies of the hemoglobin S gene from both parents Virginia He, Justin Song https://www.healthline.com/health/sickle-cell-anemia#complications D57.0 Non-billable Hb-SS disease with crisis Hb-SS DP with crisis a condition in which a person quickly loses a large volume of circulating hemoglobin. Virginia He https://en.wikipedia.org/wiki/List_of_hematologic_conditions#:~:text=Acute%20posthemorrhagic%20anemia%20(also%20known,a%20large%20loss%20of%20blood. D62 Billable Acute posthemorrhagic anemia acute posthemorrhagic anemia DP failure of the bone marrow to produce blood Virginia He https://dceg.cancer.gov/research/what-we-study/bone-marrow-failure-syndromes#:~:text=The%20inherited%20bone%20marrow%20failure,history%20of%20the%20same%20disorder. D60-D64 Aplastic and other anemias and other bone marrow failure syndromes other anemias and bone marrow failure syndromes a condition marked by a deficiency of red blood cells or of hemoglobin in the blood Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D63-/D63.8#:~:text=Anemia%20in%20other%20chronic%20diseases%20classified%20elsewhere,-2016%202017%202018&text=Code%20Manifestation%20Code-,D63.,ICD%2D10%2DCM%20D63.&text=This%20is%20the%20American%20ICD%2D10%2DCM%20version%20of%20D63. D63.8 Billable Anemia in other chronic diseases classified elsewhere anemia DP in other chronic diseases classified elsewhere decrease in the amount of red blood cells in the patient's blood stream Virginia He, Justin Song https://icd.codes/icd10cm/D6489 D64.8 Non-billable Other specified anemias other specified anemia DP patient lacks enough red blood cells to carry oxygen to the body's tissues Virginia He, Justin Song https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360 D64.9 Billable Anemia, unspecified anemia DP, unspecified a bleeding disorder caused by circulating anticoagulants (autoantibodies that neutralize specific clotting) Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D68-/D68.3 D68.3 Non-billable Hemorrhagic disorder due to circulating anticoagulants hemorrhagic disorder DP due to circulating anticoagulants Hemorrhagic diseases are caused by bleeding, or they result in bleeding Virginia He https://medlineplus.gov/ency/article/002373.htm#:~:text=article%2F002373.htm-,Hemorrhagic,result%20in%20bleeding%20(hemorrhaging). D65-D69 Coagulation defects, purpura and other hemorrhagic conditions coagulation defects, purpura and other hemorrhagic conditions abnormally low levels of thrombocytes, also known as platelets, in the blood. Virginia He https://en.wikipedia.org/wiki/Thrombocytopenia#:~:text=Thrombocytopenia%20is%20a%20condition%20characterized,platelets%20per%20microliter%20of%20blood. D69.5 Non-billable Secondary thrombocytopenia secondary thrombocytopenia DP Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood. Virginia He https://en.wikipedia.org/wiki/Thrombocytopenia#:~:text=Thrombocytopenia%20is%20a%20condition%20characterized,platelets%20per%20microliter%20of%20blood. D69.6 Billable Thrombocytopenia, unspecified thrombocytopenia DP, unspecified People with neutropenia have an unusually low number of cells called neutrophils. Neutrophils are cells in your immune system that attack bacteria and other organisms when they invade your body Virginia He https://www.webmd.com/a-to-z-guides/neutropenia-causes-symptoms-treatment#1 D70 Non-billable Neutropenia neutropenia DP white blood cell disorders effect the functionallity of the body's immune response Virginia He, Justin Song https://www.healthline.com/health/blood-cell-disorders#white-blood-cell-disorders D72.8 Non-billable Other specified disorders of white blood cells other specified disorders of white blood cells. low level of lymphocytes, which are white blood cells Virginia He, Justin Song https://en.wikipedia.org/wiki/Lymphocytopenia#:~:text=Lymphocytopenia%20is%20the%20condition%20of,an%20excessive%20level%20of%20lymphocytes. D72.810 Billable Lymphocytopenia lymphocytopenia A disorder resulting from an abnormality in the immune system Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D89-/D89.9 D89.9 Billable Disorder involving the immune mechanism, unspecified disorder involving the immune mechanism, unspecified a small class of medical conditions affecting the nervous system. Virginia He disease of the nervous system https://en.wikipedia.org/wiki/Nervous_system_disease#:~:text=Nervous%20system%20diseases%2C%20also%20known,conditions%20affecting%20the%20nervous%20system. G00-G99 Diseases of the nervous system disease (process) of the nervous system Deficiency of a coagulation factor (proteins in the blood that help control bleeding) that is not caused by genetic alterations. Causes include vitamin k deficiency, amyloidosis, and severe liver disease. Grace Whah https://medlineplus.gov/lab-tests/coagulation-factor-tests/#:~:text=Coagulation%20factors%20are%20proteins%20in,from%20losing%20too%20much%20blood. D68.4 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D68-/D68.4 acquired coagulation factor deficiency a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Virginia He, Justin Song https://www.nia.nih.gov/health/parkinsons-disease#:~:text=Parkinson's%20disease%20is%20a%20brain,have%20difficulty%20walking%20and%20talking. G20 Billable Parkinson's disease parkinson's disease process A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. Virginia He https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30- G30 Non-billable Alzheimer's disease alzheimer's disease process characterized by clinical symptoms and signs of AD that become apparent after the age of 60. Virginia He https://www.brightfocus.org/alzheimers/article/what-your-risk-heredity-and-late-onset-alzheimers-disease#:~:text=Late%2Donset%20Alzheimer's%2C%20the%20most,and%20this%20form%20of%20Alzheimer's. G30.1 Billable Alzheimer's disease with late onset alzheimer's DP with late onset A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxias and a global loss of cognitive abilities. Virginia He https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30-/G30.9 G30.9 Billable Alzheimer's disease, unspecified alzheimer's DP, unspecified a neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain. Virginia He https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.9 G40.9 Non-billable Epilepsy, unspecified epilepsy, unspecified A disorder characterized by cessation of breathing for short periods during sleep. Virginia He https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.3 G47.3 Non-billable sleep apnea sleep apnea DP A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.33 G47.33 Billable Obstructive sleep apnea (adult) (pediatric) obstructive sleep apnea DP a neurological disorder that results in diabetes Virginia He, Justin Song https://www.pijn.com/en/patients/cause-of-pain/diagnoses-per-body-region/widespread-pain/diabetic-polyneuropathy#:~:text=Diabetic%20polyneuropathy%20is%20a%20neurological,nerves%20do%20not%20work%20properly. G63.2 Diabetic polyneuropathy diabetic polyneuropathy DP any health problem that occurs in the digestive tract. Virginia He disease of the digestive system https://medlineplus.gov/ency/article/007447.htm#:~:text=A%20digestive%20disease%20is%20any,Gallstones%2C%20cholecystitis%2C%20and%20cholangitis K00-K99 Diseases of the digestive system disease (process) of the digestive system A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Virginia He https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31/K21-/K21.9 K21.9 Billable Gastro-esophageal reflux disease without esophagitis gastro-esophageal reflux disease process without esophagitis An inflammatory disorder that affects the upper and lower gastrointestinal tract; a disorder characterized by inflammation of the colon. Virginia He https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52/K52-/K52.9 K52.9 Billable Noninfective gastroenteritis and colitis, unspecified noninfective gastroenteritis and colitis DP, unspecified A condition in which stool becomes hard, dry, and difficult to pass, and bowel movements don't happen very often. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K59-/K59.0 K59.0 Non-billable Constipation constipation DP A complication of type 2 diabetes, involving extremely high blood sugar (glucose) level without the presence of ketones. Grace Whah HHS (Hyperglycemic hyperosmolar syndrome) https://medlineplus.gov/ency/article/000304.htm#:~:text=Diabetic%20hyperglycemic%20hyperosmolar%20syndrome%20(HHS,without%20the%20presence%20of%20ketones. E11.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.0 type 2 diabetes mellitus with hyperosmolarity infrequent bowel movements or difficult passage of stools that persists for several weeks or longer. Virginia He, Justin Song https://www.mayoclinic.org/diseases-conditions/constipation/symptoms-causes/syc-20354253 K59.09 Billable Other constipation other constipation DP a problem with how your stomach and bowels function or work Virginia He https://www.med.umich.edu/fbd/#:~:text=Functional%20Bowel%20Disorders%20(or%20FBD,signs%20that%20something%20is%20wrong. K59 Non-billable Other functional intestinal disorders functional intestinal disorders loose stool consistency and chronicity and absence of coexisting irritable bowel syndrome Virginia He, Justin Song https://pubmed.ncbi.nlm.nih.gov/22917168/#:~:text=A%20consensus%20definition%20for%20functional,by%20a%20preceding%20infectious%20gastroenteritis. K59.1 Billable Functional diarrhea functional diarrhea bleeding in the rectum caused by various things such as infections, proctitis, etc. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J11-/J11.0 K62.5 Non-billable Hemorrhage of anus and rectum hemorrhage of anus and rectum DP liver is damaged which makes it hard to digest food. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K71-/K71.0 K71.0 Billable Toxic liver disease with cholestasis toxic liver disease with cholestasis DP liver failure Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.0 K72.0 Non-billable Acute and subacute hepatic failure acute and subacute hepatic failure DP Abnormally dark tarry feces containing blood (usually from gastrointestinal bleeding) Virginia He https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.1 K92.1 Billable Melena melena DP disorders caused by organisms — such as bacteria, viruses, fungi or parasites. Virginia He infectious and parasitic disease processes https://www.mayoclinic.org/diseases-conditions/infectious-diseases/symptoms-causes/syc-20351173#:~:text=Infectious%20diseases%20are%20disorders%20caused,passed%20from%20person%20to%20person. A00-B99 Certain infectious and parasitic diseases infectious and parasitic disease (process) A viral or bacterial infectious process affecting the large intestine. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A09-/A09 A09 Billable Infectious gastroenteritis and colitis, unspecified infectious gastroenteritis and colitis DP, unspecified the presence of bacteria or their toxins in the blood or tissues. Virginia He https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A41-/A41.9 A41.9 Billable Sepsis, unspecified organism sepsis DP, unspecified organism A general term for diseases produced by viruses. Virginia He https://www.icd10data.com/ICD10CM/Codes/A00-B99/B25-B34/B34- B34 Viral infection of unspecified site viral infection DP of unspecified site A general term for diseases produced by viruses. Virginia He https://www.icd10data.com/ICD10CM/Codes/A00-B99/B25-B34/B34-/B34.9 B34.9 Billable Viral infection, unspecified viral infection DP, unspecified E. coli are usually harmless bacteria that help with digestion, but they can be strained and cause diarreha or worse Virginia He, Justin Song https://www.webmd.com/food-recipes/food-poisoning/what-is-e-coli#1 B96.2 Non-billable Escherichia coli [E. coli ] as the cause of diseases classified elsewhere. E. coli as the cause of diseases classified elsewhere bacteria that infect the body cause diseases Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.8 B96.8 Non-billable Other specified bacterial agents as the cause of diseases classified elsewhere other specified bacterial agents as the cause of diseases classified elsewhere bacteria that infect the body cause diseases Virginia He https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96- B96 Non-billable Other specified bacterial agents as the cause of diseases classified elsewhere other bacterial agents as the cause of diseases classified elsewhere viruses that infect the body cause diseases Virginia He https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97 B97 Non-billable Viral agents as the cause of diseases classified elsewhere viral agents as the cause of diseases a type of common virus that infects humans, typically leading to an upper respiratory infection Virginia He https://www.medicinenet.com/script/main/art.asp?articlekey=22789 B97.2 Non-billable Coronavirus as the cause of diseases classified elsewhere coronavirus as the cause of diseases a type of common virus that infects humans, typically leading to an upper respiratory infection Virginia He, Justin Song https://www.medicinenet.com/script/main/art.asp?articlekey=22789 B97.29 Billable Other coronavirus as the cause of diseases classified elsewhere other coronavirus as the cause of diseases infection/disease caused by a virus Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.89 B97.89 Billable Other viral agents as the cause of diseases classified elsewhere other viral agents as the cause of diseases Infectious diseases are disorders caused by organisms — such as bacteria, viruses, fungi or parasites. Virginia He https://www.mayoclinic.org/diseases-conditions/infectious-diseases/symptoms-causes/syc-20351173#:~:text=Infectious%20diseases%20are%20disorders%20caused,passed%20from%20person%20to%20person. B99 Non-billable Other and unspecified infectious diseases other and unspecified infectious diseases An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Virginia He https://www.cancer.gov/publications/dictionaries/cancer-terms/def/neoplasm C00-D49 Neoplasms neoplasm DP a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. Virginia He https://en.wikipedia.org/wiki/Lung_cancer#:~:text=Lung%20cancer%2C%20also%20known%20as,other%20parts%20of%20the%20body. C34.9 Non-billable Malignant neoplasm of unspecified part of bronchus or lung malignant neoplasm DP of bronchus or lung a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. Virginia He https://www.icd10data.com/ICD10CM/Codes/C00-D49/C50-C50/C50-/C50.9 C50.9 Non-billable A primary or metastatic malignant neoplasm involving the breast. malignant neoplasm DP of breast A primary or metastatic malignant tumor involving the prostate gland. Virginia He https://www.icd10data.com/ICD10CM/Codes/C00-D49/C60-C63/C61-/C61 C61 Billable Malignant neoplasm of prostate malignant neoplasm DP of prostate Cancer that has spread from the original (primary) tumor to the liver. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.7 C78.7 Billable Secondary malignant neoplasm of liver and intrahepatic bile duct secondary malignant neoplasm of liver and intrahepatic bile duct DP Cancer that has spread from the original (primary) tumor to the bone. Virginia He https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.5 C79.5 Non-billable Secondary malignant neoplasm of bone and bone marrow secondary malignant neoplasm of bone and bone marrow DP A malignancy of mature plasma cells engaging in monoclonal immunoglobulin production. Virginia He https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C90-/C90.0 C90.0 Non-billable Multiple myeloma multiple myeloma DP Diseases and conditions affecting the eyes Virginia He https://www.icd10data.com/ICD10CM/Codes/H00-H59 H00-H59 Diseases of the eye and adnexa disease (process) of the eye and adnexa a common eye disorder among people over 50. It causes blurred or reduced central vision, due to thinning of the macula Virginia He https://www.mayoclinic.org/diseases-conditions/dry-macular-degeneration/symptoms-causes/syc-20350375#:~:text=Dry%20macular%20degeneration%20is%20a,your%20direct%20line%20of%20sight. H35.3 Non-billable Degeneration of macula and posterior pole degeneration of macula and posterior pole damage in the eyes due to diabetes Virginia He, Justin Song https://icd.codes/icd10cm/H36 H36.0 Billable Retinal disorders in diseases classified elsewhere retinal disorders in diseases classified elsewhere A disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow. Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/H00-H59/H40-H42/H40-/H40.9 H40.9 Billable Unspecified glaucoma unspecified glaucoma Diseases and conditions affecting the skin and subcutaneous tissue Virginia He https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99 L80-L99 Other disorders of the skin and subcutaneous tissue disorders of the skin and subcutaneous tissue are injuries to skin and underlying tissue resulting from prolonged pressure on the skinv Virginia He https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone. L89.1 Non-billable Pressure ulcer of back pressure ulcer of back a defect in the skin below the level of knee persisting for more than six weeks and shows no tendency to heal after three or more months. Virginia He https://www.hindawi.com/journals/ulcers/2013/413604/ L97 Non-billable Pressure ulcer of back non-pressure chronic ulcer of lower limb, not elsewhere classified Diseases and conditions affecting the muskoskeletal system and connective tissue Virginia He https://www.icd10data.com/ICD10CM/Codes/M00-M99 M00-M99 Diseases of the musculoskeletal system and connective tissue disease (process) of the musculoskeletal system and connective tissue Acute or chronic pain in the lumbar or sacral regions Virginia He https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54.5 M54.5 Billable Low back pain low back pain DP Muscle disorders that cause weakness, pain or even paralysis Virginia He https://medlineplus.gov/muscledisorders.html M62.89 Billable Other specified disorders of muscle other specified disorders of muscle A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/M00-M99/M70-M79/M79-/M79.1 M79.1 Non-billable Myalgia myalgia DP muscle aches and pain, which can involve ligaments, tendons and fascia, the soft tissues that connect muscles, bones and organs Virginia He, Justin Song https://www.hopkinsmedicine.org/health/conditions-and-diseases/myalgia M79.10 Billable Myalgia, unspecified site myalgia, unspecified site DP Osteoporosis is the most common bone disease and is caused by the thinning of the bones Virginia He, Justin Song https://www.clearcareonline.com/blog/managing-a-homecare-agency/bone-diseases-in-the-elderly/#:~:text=Osteoporosis%20is%20the%20most%20common,a%20senior%20factures%20a%20bone. M80.0 Non-billable Age-related osteoporosis with current pathological fracture age-related osteoporosis with current pathological fracture a viral respiratory illness caused by a coronavirus called SARS-associated coronavirus (SARS-CoV). Virginia He, Justin Song https://www.cdc.gov/sars/index.html U04.9 Severe acute respiratory syndrome, unspecified severe acute respiratory syndrome, unspecified when you have symptoms of both asthma and chronic obstructive pulmonary disease Virginia He https://www.webmd.com/lung/copd/asthma-copd-overlap J45.8 Mixed asthma mixed asthma DP injury/other consequences caused by external sources Virginia He https://www.icd10data.com/ICD10CM/Codes/S00-T88 S00-T88 Injury, poisoning and certain other consequences of external causes  injury, poisoning and certain other consequences of external causes  A violent jar or shock, or the condition which results from such an injury. Virginia He https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S06/S06.0-/S06.0 S06.0 Concussion concussion DP Fractures of the short, constricted portion of the thigh bone between the femur head and the trochanters. Virginia He https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.0-/S72.0 S72.0 Fracture of head and neck of femur fracture of head and neck of femur DP there is a need for specific instruction for the patient Virginia He, Justin Song https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81 T81.0 Complications of procedures, not elsewhere classified complications of procedures an event which results in a person coming to rest inadvertently on the ground or floor or other lower level Virginia He https://www.who.int/news-room/fact-sheets/detail/falls W00-W19 Slipping, tripping, stumbling and falls slipping, tripping, stumbling and falls an event which results in a person coming to rest inadvertently on the ground or floor or other lower level Virginia He https://www.who.int/news-room/fact-sheets/detail/falls W19 Unspecified fall unspecified fall liver failure Virginia He https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.0 K70.3 Non-billable Alcoholic cirrhosis of liver alcoholic cirrhosis DP of liver An ulceration caused by prolonged pressure on the skin and tissues when one stays in one position for a long period of time, such as lying in bed. Virginia He https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89 L89 Non-billable Pressure ulcer pressure ulcer A type of permanent damage to muscles and nerves that results from prolonged lack blood flow to those tissues. It is characterized by shortening and stiffening of the muscles. Virginia He https://www.icd10data.com/ICD10CM/Codes/S00-T88/T79-T79/T79-/T79.6 T79.6 Traumatic ischemia of muscle traumatic ischemia DP of muscle Virginia He https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460787/#:~:text=without%20HIV%20infection.-,Introduction,MDR%2DTB%5B2%5D. tuberculous infection caused by resistance to at least isoniazid and rifampin, the two most potent TB drugs. U50.00 Primary multidrug resistant tuberculosis primary multidrug resistant tuberculosis to descend freely by the force of gravity Virginia He https://www.merriam-webster.com/dictionary/fall W17 Non-billable Other fall from one level to another fall from one level to another symptoms, signs, abnormal results of clinical or other investigative procedures, and ill-defined conditions regarding which no diagnosis classifiable elsewhere is recorded. https://www.icd10data.com/ICD10CM/Codes/R00-R99 R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified symptoms, signs and abnormal clinical and laboratory findings A disorder characterized by laboratory test results that indicate blood in the urine. https://www.icd10data.com/ICD10CM/Codes/R00-R99/R30-R39/R31-/R31 R31 Non-billable Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified hematuria DP Loss of sense of smell https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R43-/R43.0 R43.0 Billable Anosmia anosmia DP Sepsis associated with organ dysfunction distant from the site of infection. https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R65-/R65.20 R65.20 Billable Severe sepsis without septic shock severe sepsis DP without septic shock Persons encountering health services for examinations, Genetic carrier and genetic susceptibility to disease, Resistance to antimicrobial drugs, etc Virginia He https://coder.aapc.com/icd-10-codes-range/298#:~:text=ICD%2D10%20Code%20range%20(Z00,receptor%20status%2C%20Retained%20foreign%20body Z00-Z99 Factors influencing health status and contact with health services factors influencing health status and contact with health services Encounter for general adult medical examination Non-billable Virginia He https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z00-/Z00.0 Z00.0 Encounter for general adult medical examination encounter for general adult medical examination a procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor. Virginia He https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z51-/Z51.81 Z51.81 Billable Encounter for therapeutic drug level monitoring encounter for therapeutic drug level monitoring Problem related to social environment Virginia He https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z60-/Z60.9 Z60.9 Billable Problem related to social environment, unspecified problem related to social environment long term use of asipirin Virginia He https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z79-/Z79.82 Z79.82 Billable Long term (current) use of aspirin long term (current) use of aspirin when immune system reacts to a foreign substance or food that doesn't cause a reaction in most people Virginia He https://www.mayoclinic.org/diseases-conditions/allergies/symptoms-causes/syc-20351497#:~:text=Allergies%20occur%20when%20your%20immune,produces%20substances%20known%20as%20antibodies. Z88.1 Billable Allergy status to other antibiotic agents status allergy status to other antibiotic agents status inflammation of the glomeruli, which are structures in your kidneys that are made up of tiny blood vessels. These knots of vessels help filter your blood and remove excess fluids. If your glomeruli are damaged, your kidneys will stop working properly, and you can go into kidney failure Virginia He https://icd.codes/icd10cm/N08#:~:text=N08%20is%20a%20billable%20ICD,to%20specify%20a%20medical%20diagnosis. N08.3 glomerular disorders in diseases classified elsewhere glomerular disorders Eric Wan, Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75 H65-H75 Diseases of middle ear and mastoid middle ear or mastoid DP Eric Wan, Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H80-H83 H80-H83 Diseases of inner ear inner ear DP Eric Wan, Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H95-H95 H95-H95 Not billable Intraoperative and postprocedural complications and disorders of ear and mastoid process, not elsewhere classified Intraoperative and postprocedural complications and disorders of ear and mastoid process, not elsewhere classified Eric Wan, Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75 H65-H75 Diseases of middle ear and mastoid Conductive and sensorineural hearing loss Oliver He hearing loss Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H90-H94/H91-/H91.90 H91.90 Billable Unspecified hearing loss, unspecified ear Unspecified hearing loss, unspecified ear Oliver He interoperative and postprocedural ear and mastoid disease process Loss of memory, language, problem-solving and other thinking abilities in an Alzheimer's patient Grace Whah https://www.alz.org/alzheimers-dementia/what-is-dementia#:~:text=Dementia%20is%20a%20general%20term,most%20common%20cause%20of%20dementia. F00.2 https://icd.who.int/browse10/2014/en#!/F00-F09 dementia in Alzheimer’s disease, atypical or mixed type Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H60-H62/H61-/H61.0 H61.0 Chondritis and perichondritis of external ear chondritis or perichondritis of external ear Oliver He https://www.icd10data.com/ICD10CM/Codes/H60-H95/H65-H75/H65-/H65 H65 Non-Billable Nonsuppurative otitis media Nonsuppurative otitis media DP Hypertension (Elevated blood pressure) in patients with stage 5 kidney disease or end stage renal disease Grace Whah https://www.webmd.com/hypertension-high-blood-pressure/guide/what-is-renal-hypertension#:~:text=Renal%20hypertension%2C%20also%20called%20renovascular,blood%20vessels%20of%20the%20kidney. I12.0 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16/I12-/I12.0 hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease Presence of a blockage in one of the pulmonary arteries in the lungs in patients with acute cor pulmonale (acute right heart failure) Grace Whah https://www.mayoclinic.org/diseases-conditions/pulmonary-embolism/symptoms-causes/syc-20354647#:~:text=Pulmonary%20embolism%20is%20a%20blockage,body%20(deep%20vein%20thrombosis). I26.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I26-I28/I26-/I26.0 pulmonary embolism with acute cor pulmonale Backflow of blood from the left ventricle into the left atrium due to imperfect closure of the mitral valve Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I34-/I34.0 I34.0 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I34-/I34.0 nonrheumatic mitral (valve) insufficiency upper respiratory system is infected in multiple sites and parts will become inflamed or damaged. Grace Whah https://www.healthline.com/health/acute-upper-respiratory-infection#:~:text=An%20acute%20URI%20is%20a,pharyngitis%2C%20epiglottitis%2C%20and%20tracheobronchitis. J06.8 https://icd.who.int/browse10/2010/en#!J06.8 acute upper respiratory infections of multiple sites Pneumonia (infection that inflames the air sacs in the lungs) caused by Klebsiella pneumoniae bacteria Grace Whah https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia. J15.0 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.0 pneumonia due to Klebsiella pneumoniae Pneumonia (infection that inflames the air sacs in the lungs) caused by Pseudomonas bacteria Grace Whah https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia. J15.1 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.1 pneumonia due to Pseudomonas A condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls. Grace Whah https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.9 J43.9 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J43-/J43.9 emphysema, unspecified Injury to elbow skin and underlying tissue resulting from prolonged pressure on skin around elbow Grace Whah https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone. L89.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.0 pressure ulcer of elbow The existence of type 2 diabetes mellitus in pregnant patients or patients who had a child within the last 6 weeks Grace Whah https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.1 O24.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.1 pre-existing type 2 diabetes mellitus, in pregnancy, childbirth and the puerperium Lymph nodes in one particular area of the body swell up Grace Whah https://www.medicalnewstoday.com/articles/324105#causes R59.0 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R59-/R59.0 localized enlarged lymph nodes A disorder characterized by bleeding from the nose Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04.0 R04.0 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04.0 epistaxis Abnormal buildup of fluid in the abdomen Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R18-/R18 R18 Non-billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R18-/R18 ascites Death in circumstances where the body of the deceased was found and no cause could be discovered Grace Whah https://icd.who.int/browse10/2010/en#!R98 R98 https://icd.who.int/browse10/2010/en#!R98 unattended death Infection in the body found after a procedure Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.4 T81.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.4 infection following a procedure Presence of implant into the urethra to help control urine leakage (foley catheter, ureteral stent, pessary, etc). Grace Whah https://medlineplus.gov/ency/article/007373.htm Z96.0 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.0 presence of urogenital implants Has bone/tendon implants in body Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.7 Z96.7 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z96-/Z96.7 presence of other bone and tendon implants Inflammation of the liver caused by hepatitis c virus lasting six months or more Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.2 B18.2 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.2 chronic viral hepatitis C Infection of the mucous membranes of the mouth by a fungus of the genus candida Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37.0 B37.0 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37.0 candidal stomatitis Cancer that has spread from the original tumor to the lung Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.0 C78.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.0 secondary malignant neoplasm of lung Iron deficiency anemia (a condition in which blood lacks adequate healthy blood cells) caused by chronic blood loss Grace Whah https://www.mayoclinic.org/diseases-conditions/iron-deficiency-anemia/symptoms-causes/syc-20355034 D50.0 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D50-D53/D50-/D50.0 iron deficiency anemia secondary to blood loss (chronic) The prescense of diabetic ketoacidosis (body produces high levels of ketones and not enough insulin) in type 1 diabetic patients Grace Whah https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551#:~:text=Diabetic%20ketoacidosis%20is%20a%20serious,can't%20produce%20enough%20insulin. E10.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.1 type 1 diabetes mellitus with ketoacidosis Overweight and obesity caused by miscellaneous disorders Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.8 E66.8 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68/E66-/E66.8 other obesity Delirium of mixed origin, postoperative delirium Grace Whah https://icd.who.int/browse10/2010/en#/F05.8 F05.8 https://icd.who.int/browse10/2010/en#/F05.8 other dilirum An abrupt change in the brain that causes mental confusion and emotional disruption with unspecified cause Grace Whah https://www.healthline.com/health/delirium#:~:text=Delirium%20is%20an%20abrupt%20change,after%20surgery%2C%20or%20with%20dementia. F05.9 https://icd.who.int/browse10/2010/en#/F05.9 delirium, unspecified Personality/behavioral disorders caused by physiological disorder Grace Whah https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F07-/F07.8 F07.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F01-F09/F07-/F07.8 other personality and behavioral disorders due to known physiological condition A mental disorder in which a person has trouble telling the difference between real and unreal experiences, thinking logically, and behaving normally in social situations. Grace Whah https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F20-/F20.9 F20.9 Billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F20-/F20.9 schizophrenia, unspecified A disorder of the nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control Grace Whah https://www.icd10data.com/ICD10CM/Codes/G00-G99/G35-G37/G35-/G35 G35 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G35-G37/G35-/G35 multiple sclerosis Paralysis of one side of the body with unspecified cause Grace Whah https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.9 G81.9 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.9 hemiplegia, unspecified An infection that inflames the air sacs in one or both lungs caused by Escherichia coli bacteria Grace Whah https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia. J15.5 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J15-/J15.5 pneumonia due to Escherichia coli Nonallergic asthma (a condition in which your airways narrow and swell) Grace Whah https://icd.who.int/browse10/2016/en#/J45.1 J45.1 https://icd.who.int/browse10/2016/en#/J45.1 nonallergic asthma Asthma symptoms (airway swelling) occuring fewer than three times a week Grace Whah https://www.webmd.com/asthma/qa/what-is-mild-intermittent-asthma#:~:text=ANSWER,age%2C%20sex%2C%20and%20height. J45.20 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J40-J47/J45-/J45.20 mild intermittent asthma, uncomplicated Unspecified late stage scarring of the liver Grace Whah https://www.mayoclinic.org/diseases-conditions/cirrhosis/symptoms-causes/syc-20351487 K74.6 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K74-/K74.6 other and unspecified cirrhosis of liver A chronic inflammation of the tear and salivary glands, often accompanied by rheumatoid arthritis and the presence of autoantibodies in the blood Grace Whah Sjogren syndrome https://www.icd10data.com/ICD10CM/Codes/M00-M99/M30-M36/M35-/M35.0 M35.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M30-M36/M35-/M35.0 sicca syndrome [Sjögren] Wasting or thinning of muscle tissue Grace Whah https://www.healthline.com/health/muscle-atrophy#:~:text=Muscle%20atrophy%20is%20when%20muscles,can%20result%20in%20muscle%20wasting. M62.50 Billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M60-M63/M62-/M62.50 muscle wasting and atrophy, not elsewhere classified, unspecified site Genetic malformation of the tongue Grace Whah https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45/Q38-/Q38.3 Q38.3 Billable https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45/Q38-/Q38.3 other congenital malformations of tongue Unspecified anterior chest-wall pain Grace Whah https://icd.who.int/browse10/2016/en#/R07.3 R07.3 https://icd.who.int/browse10/2016/en#/R07.3 other chest pain Unspecified fracture of the proximal femur between the cervical region and the shaft Grace Whah https://www.sciencedirect.com/science/article/pii/S1877056813002740#:~:text=Definition,in%20the%20definition%20%5B6%5D. S72.10 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.1-/S72.10 unspecified trochanteric fracture of femur Administration of immunotherapy Grace Whah https://icd.who.int/browse10/2016/en#/Z29.1 Z29.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z29-/Z29.1 encounter for prophylactic immunotherapy Lack of familial support Grace Whah https://icd.who.int/browse10/2016/en#/Z63.2 Z63.2 https://icd.who.int/browse10/2016/en#/Z63.2 inadequate family support Continous supervision needed, problems related to care provider dependency Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.3 Z74.3 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74.3 need for continuous supervision Personal history of exposure to radiation Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.3 Z92.3 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z92-/Z92.3 personal history of irradiation Patient has prosthetic heart valve Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.2 Z95.2 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.2 presence of prosthetic heart valve Patient was exposed to SARS-associated coronavirus Grace Whah http://www.icd9data.com/2015/Volume1/V01-V91/V01-V09/V01/V01.82.htm V01.82 Billable http://www.icd9data.com/2015/Volume1/V01-V91/V01-V09/V01/V01.82.htm exposure to SARS-associated coronavirus Diseases in body caused by Staphylococcus aureus bacteria Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.6 B95.6 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.6 Staphylococcus aureus as the cause of diseases classified elsewhere Secondary abnormal growth of cells in the pleural space (the cavity between the lungs and chest wall that contains pleural fluid) Grace Whah https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=22&contentid=pleuraltumors#:~:text=Pleural%20tumors%20are%20found%20in,and%20difficult%20to%20operate%20on. C78.2 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C78-/C78.2 secondary malignant neoplasm of pleura A disease characterized by the growth of tiny collections of inflammatory cells (granulomas) in any part of your body https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358#:~:text=Sarcoidosis%20is%20a%20disease%20characterized,skin%2C%20heart%20and%20other%20organs. D86.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.8 sarcoidosis of other sites An unspecified condition in which the adrenal glands do not produce adequate amounts of steroid hormones (cortisol) Grace Whah https://en.wikipedia.org/wiki/Adrenal_insufficiency#:~:text=Adrenal%20insufficiency%20is%20a%20condition,potassium%20secretion%2C%20and%20water%20retention. E27.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E20-E35/E27-/E27.4 other and unspecified adrenocortical insufficiency A condition caused by not getting enough calories or the right amount of key nutrients, such as vitamins and minerals, that are needed for health. Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E46-/E46 E46 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46/E46-/E46 unspecified protein-calorie malnutrition A nutritional condition produced by a deficiency of B group vitamins (folic acid, B-12) in the diet Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E53-/E53.8 E53.8 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64/E53-/E53.8 deficiency of other specified B group vitamins Disorders in the processing, absorption, transport, storage, and utilization of phosphorus in the body Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.3 E83.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E83-/E83.3 disorders of phosphorus metabolism and phosphatases Unspecified loss of memory, language,and other thinking abilities in a patient with Alzheimer's Grace Whah https://www.alz.org/alzheimers-dementia/what-is-dementia#:~:text=Dementia%20is%20a%20general%20term,most%20common%20cause%20of%20dementia. F00.9 https://icd.who.int/browse10/2016/en#/F00.9 dementia in Alzheimer disease, unspecified Single major depressive disorder episode (a depressed mood for two weeks or more) Grace Whah https://en.wikipedia.org/wiki/Major_depressive_episode F32.1 Billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.1 major depressive disorder, single episode, moderate Recurrent major depressive disorder episodes (a depressed mood for two weeks or more) Grace Whah https://en.wikipedia.org/wiki/Major_depressive_episode F33.9 Billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F33-/F33.9 major depressive disorder, recurrent, unspecified A brief stroke (from a few minutes to an hour) of cerebral dysfunction when the blood supply to this part of the brain is blocked Grace Whah https://medlineplus.gov/transientischemicattack.html#:~:text=A%20transient%20ischemic%20attack%20(TIA,one%20side%20of%20the%20body G45.9 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G45-/G45.9 transient cerebral ischemic attack, unspecified A neuromuscular condition of spasticity that results in the muscles on one side of the body to be in a constant state of contraction Grace Whah https://en.wikipedia.org/wiki/Spastic_hemiplegia#:~:text=Spastic%20hemiplegia%20is%20a%20neuromuscular,impairment%20umbrella%20of%20cerebral%20palsy. G81.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G80-G83/G81-/G81.1 spastic hemiplegia Failure of adequate output by the left ventricle Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-/I50.1 I50.1 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I50-/I50.1 left ventricular failure, unspecified The result of thickening and hardening of the walls of the arteries in the brain Grace Whah https://www.ninds.nih.gov/Disorders/All-Disorders/Cerebral-Arteriosclerosis-Information-Page#:~:text=Definition,can%20cause%20serious%20health%20problems. I67.2 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.2 cerebral atherosclerosis An infection that inflames the air sacs in one or both lungs caused by Parainfluenza virus Grace Whah https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia. J12.2 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J12-/J12.2 parainfluenza virus pneumonia Respiratory tract infections not specified as acute, chronic, lower, or upper Grace Whah https://icd.who.int/browse10/2019/en#/J98.7 J98.7 https://icd.who.int/browse10/2019/en#/J98.7 respiratory infection, not elsewhere classified Injury to hip skin and underlying tissue resulting from prolonged pressure on skin around hip Grace Whah https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893#:~:text=Bedsores%20%E2%80%94%20also%20called%20pressure%20ulcers,%2C%20ankles%2C%20hips%20and%20tailbone. L89.2 Non-billable https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.2 pressure ulcer of hip When water content of the body cartilage increases and the protein makeup of cartilage degenerates Grace Whah https://www.novusbio.com/diseases/polyosteoarthritis-unspecified#:~:text=Polyosteoarthritis%20is%20related%20to%20the,and%20eventually%20cartilage%20will%20degenerate. M15.9 Billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M15-M19/M15-/M15.9 polyosteoarthritis, unspecified The feeling of being anger or irritated Grace Whah https://www.merriam-webster.com/dictionary/irritable R45.4 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R45-/R45.4 irritability and anger Anarthria is a severe form of dysarthria. Dysarthria is a motor speech disorder that occurs when someone can't coordinate or control the muscles used for speaking. Grace Whah https://www.healthline.com/health/anarthria#:~:text=Anarthria%20is%20a%20severe%20form,t%20articulate%20speech%20at%20all. R47.4 Billable https://www.icd10data.com/search?s= dysarthria and anarthria Uncommon severe weight loss for an unspecified cause Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.4 R63.4 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.4 abnormal weight loss This describes the circumstance causing an injury, not the nature of the injury. The injury in this case is caused by the lack of administration of surgical or medical care. Grace Whah https://www.icd10data.com/ICD10CM/Codes/V00-Y99/Y62-Y69/Y66-/Y66 Y66 Billable https://www.icd10data.com/ICD10CM/Codes/V00-Y99/Y62-Y69/Y66-/Y66 nonadministration of surgical and medical care Anemia (a condition in which you lack enough healthy red blood cells to carry adequate oxygen to your body's tissues) in patients with neoplasm (tumors) Grace Whah https://www.mayoclinic.org/diseases-conditions/anemia/symptoms-causes/syc-20351360#:~:text=Anemia%20is%20a%20condition%20in,range%20from%20mild%20to%20severe. D63.0 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D60-D64/D63-/D63.0 anemia in neoplastic disease Patient had a viral disease screening done Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z11-/Z11.5 Z11.5 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z00-Z13/Z11-/Z11.5 encounter for screening for other viral diseases Patient had specificed bacterial disease / infectious disease Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z22-/Z22.3 Z22.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z20-Z29/Z22-/Z22.3 carrier of other specified bacterial diseases Patient had implanted devices managed and adjusted Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z45-/Z45.8 Z45.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z45-/Z45.8 encounter for adjustment and management of other implanted devices Patient did not undergo treatment due to patients decision Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z53-/Z53.2 Z53.2 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z53-/Z53.2 procedure and treatment not carried out because of patient's decision for other and unspecified reasons Inflammation of the liver in humans caused by hepatitis b virus lasting six months or more. Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.1 B18.1 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B18-/B18.1 chronic viral hepatitis B without delta-agent The aftereffect of respiratory disease and tuberculosis Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B90-B94/B90-/B90.9 B90.9 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B90-B94/B90-/B90.9 sequelae of respiratory and unspecified tuberculosis Diseases in the body caused by enterococcus genus Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.2 B95.2 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95.2 Enterococcus as the cause of diseases classified elsewhere Diseases in the body caused by Klebsiella pneumoniae bacteria Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.1 B96.1 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B96-/B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified elsewhere Primary cancerous tumor of the colon Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C18-/C18.9 C18.9 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C18-/C18.9 malignant neoplasm of colon, unspecified Carcinoma (cancerous tumor) of the liver Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.0 C22.0 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.0 liver cell carcinoma A stomach bug or stomach flu Grace Whah https://www.healthgrades.com/right-care/digestive-health/enteritis#:~:text=Most%20people%20call%20viral%20enteritis,Parasites%20include%20Giardia%20and%20Cryptosporidium. A08.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/A00-A09/A08-/A08.3 other viral enteritis Sepsis (when the body's response to an infection is out of balance) caused by a staph infection. Could lead to organ damage or failure https://www.sciencedaily.com/releases/2018/07/180726162039.htm#:~:text=For%20patients%20diagnosed%20with%20a,the%20people%20who%20develop%20it. A41.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A41-/A41.0 sepsis due to Staphylococcus aureus Hepatitis (not hepatitis A or hepatitis B); inflammation of the liver Grace Whah https://www.cdc.gov/hepatitis/abc/index.htm#:~:text=Hepatitis%20means%20inflammation%20of%20the,medical%20conditions%20can%20cause%20hepatitis. B17.8 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B15-B19/B17-/B17.8 other specified acute viral hepatitis Diseases caused by other viral agents Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.8 B97.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B97-/B97.8 other viral agents as the cause of diseases classified elsewhere Tumor of the connective tissues of the bile ducts Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.1 C22.1 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C15-C26/C22-/C22.1 intrahepatic bile duct carcionoma Cancerous tumor of a respiratory organ (upper lobe, bronchus, or lung) Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C30-C39/C34-/C34.1 C34.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C30-C39/C34-/C34.1 malignant neoplasm of upper lobe, bronchus or lung Cancer of the endometrium Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C51-C58/C54-/C54.1 C54.1 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C51-C58/C54-/C54.1 malignant neoplasm of endometrium A lung disease characterized by the growth of inflammatory cells (granulomas) in the lungs Grace Whah https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358 D86.0 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.0 sarcoidosis of lung A disease characterized by the growth of inflammatory cells (granulomas) in a specific part of your body (most commonly liver, lungs, skin, and lymph nodes) https://www.mayoclinic.org/diseases-conditions/sarcoidosis/symptoms-causes/syc-20350358 D86.9 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D86-/D86.9 sarcoidosis, unspecified An uncommon condition characterized by elevated levels of immunoglobulins in your blood Grace Whah PHGG https://www.healthline.com/health/hypergammaglobulinemia D89.0 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D80-D89/D89-/D89.0 polyclonal hypergammaglobulinemia A common form of hyperthyroidism affecting the entire thyroid gland and causing the gland to become enlarged Grace Whah Graves' disease https://www.virginiamason.org/thyrotoxicosis#:~:text=As%20many%20as%2070%2D80,gland%20becomes%20enlarged%20(goiter). E05.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07/E05-/E05.0 thyrotoxicosis with diffuse goiter The prescense of diabetic ketoacidosis (body produces high levels of ketones and not enough insulin) in type 1 diabetic patients, resulting in a coma Grace Whah https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551#:~:text=Diabetic%20ketoacidosis%20is%20a%20serious,can't%20produce%20enough%20insulin. E10.11 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.11 type 1 diabetes mellitus with ketoacidosis with coma Type 1 diabetes (body cannot break down sugars very easily) with unspecified complications Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.8 E10.8 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E10-/E10.8 type 1 diabetes mellitus with unspecified complications Type 2 diabetes with diabetic macular edema (when blood vessels in the eye retina leak fluid, causing swelling in the macula) Grace Whah https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy#:~:text=Diabetic%20retinopathy%20can%20lead%20to,a%20part%20of%20the%20retina). E11.311 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.311 type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema Type 2 diabetes with diabetic retinopathy (vision loss and blindness) without macular edema (swelling in the macula cause by fluid leaking from the retina) Grace Whah https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/diabetic-retinopathy#:~:text=Diabetic%20retinopathy%20can%20lead%20to,a%20part%20of%20the%20retina). E11.319 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.319 type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema Cataracts (cloudy area in the lens of your eye) caused by type 2 diabetes Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.36 E11.36 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.36 type 2 diabetes mellitus with diabetic cataract Other eye diseases caused by type 2 diabetes Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.39 E11.39 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13/E11-/E11.39 type 2 diabetes mellitus with other diabetic ophthalmic complication The coexistences of 2 or more primary acid-base disorders in the same patient Grace Whah https://www.sciencedirect.com/science/article/abs/pii/S0195561689500329#:~:text=A%20mixed%20acid%2Dbase%20disorder,and%20chemistries%2C%20and%20anion%20gap. E87.4 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.4 mixed disorder of acid-base balance Development of hypothyroidism (when the thyroid gland doesn't produce enough of crucial hormones) following surgery Grace Whah https://www.mayoclinic.org/diseases-conditions/hypothyroidism/symptoms-causes/syc-20350284 E89.0 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E89-E89/E89-/E89.0 postprocedural hypothyroidism Dementia that is gradual in onset, following a number of transient ischaemic episodes which produce an accumulation of infarcts in the cerebral parenchyma Grace Whah https://icd.who.int/browse10/2016/en#/F01.1 F01.1 https://icd.who.int/browse10/2016/en#/F01.1 multi-infarct dementia Other vascular dementia (problems with reasoning, planning, judgement, memory, and other thought processes caused by brain damage from impaired blood blow to your brain) Grace Whah https://www.mayoclinic.org/diseases-conditions/vascular-dementia/symptoms-causes/syc-20378793#:~:text=Vascular%20dementia%20is%20a%20general,t%20always%20cause%20vascular%20dementia. F01.8 https://icd.who.int/browse10/2016/en#/F01.8 other vascular dementia Unspecified vascular dementia (problems with reasoning, planning, judgement, memory, and other thought processes caused by brain damage from impaired blood blow to your brain) Grace Whah https://www.mayoclinic.org/diseases-conditions/vascular-dementia/symptoms-causes/syc-20378793#:~:text=Vascular%20dementia%20is%20a%20general,t%20always%20cause%20vascular%20dementia. F01.9 https://icd.who.int/browse10/2016/en#/F01.9 vascular dementia, unspecified A disorder characterized by the development either of a single delusion or of a set of related delusions that are usually persistent and sometimes lifelong. Grace Whah https://icd.who.int/browse10/2016/en#/F22.0 F22.0 https://icd.who.int/browse10/2016/en#/F22.0 delusional disorder A condition that affects the way your brain processes information and causes you to lose touch with reality. In this case, not caused by substance abuse or a known physiological condition Grace Whah https://www.webmd.com/schizophrenia/guide/what-is-psychosis#1 F29 Billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F20-F29/F29-/F29 unspecified psychosis not due to a substance or known physiological condition Single episode of major depressive disorder (persistent feeling of sadness and loss of interest) Grace Whah https://www.mayoclinic.org/diseases-conditions/depression/symptoms-causes/syc-20356007 F32.0 Billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F30-F39/F32-/F32.0 major depressive disorder, single episode, mild A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event. Grace Whah PTSD https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F43-/F43.1 F43.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F40-F48/F43-/F43.1 post-traumatic stress disorder Other form of Alzheimer's disease (diseases where dementia symptoms gradually worsen over time) Grace Whah https://www.alz.org/alzheimers-dementia/what-is-alzheimers#:~:text=Alzheimer's%20is%20a%20progressive%20disease,and%20respond%20to%20their%20environment. G30.8 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G30-G32/G30-/G30.8 other Alzheimer's disease Epilepsy with simple partial seizures and focal EEG abnoralities Grace Whah https://www.sciencedirect.com/topics/neuroscience/localization-related-epilepsy#:~:text=Benign%20focal%20epilepsies%20of%20childhood%20are%20idiopathic%20localization%E2%80%90related%20epilepsies,a%20tendency%20for%20spontaneous%20remission. G40.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.1 localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures Epilepsy with complex partial seizures and focal EEG abnoralities Grace Whah https://www.sciencedirect.com/topics/neuroscience/localization-related-epilepsy#:~:text=Benign%20focal%20epilepsies%20of%20childhood%20are%20idiopathic%20localization%E2%80%90related%20epilepsies,a%20tendency%20for%20spontaneous%20remission. G40.2 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G40-/G40.2 localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness Grace Whah MG https://www.icd10data.com/ICD10CM/Codes/G00-G99/G70-G73/G70-/G70.0 G70.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G70-G73/G70-/G70.0 myasthenia gravis Cataracts (cloudy area in the lens of your eye) in the center of the eye lens due to age Grace Whah https://www.nvisioncenters.com/cataracts/types/#:~:text=Nuclear%20cataracts%20are%20often%20a,they%20often%20impact%20distance%20vision. H25.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H25-/H25.1 age-related nuclear cataract Cataracts (cloudy area in the lens of your eye) caused by unspecified reason Grace Whah https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H26-/H26.9 H26.9 Billable https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28/H26-/H26.9 unspecified cataract A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of eye diseases (e.g., retinal diseases and glaucoma); optic nerve diseases, and other conditions. Grace Whah https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H53-/H53.4 H53.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H53-/H53.4 visual field defects Cannot see out of one eye Grace Whah https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H54-/H54.4 H54.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54/H54-/H54.4 blindness, one eye A heart attack in the absence of observable q wave abnormalities in the ecg. Grace Whah https://www.mayoclinic.org/diseases-conditions/heart-attack/symptoms-causes/syc-20373106 I21.4 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I21-/I21.4 non-ST elevation (NSTEMI) myocardial infarction A condition in which arteries become narrower and slow down the flow of blood accompanied with chest pain Grace Whah https://www.ottawaheart.ca/heart-condition/coronary-artery-disease-atherosclerosis#:~:text=Coronary%20artery%20disease%20(CAD)%20is,down%20the%20flow%20of%20blood. I25.11 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I20-I25/I25-/I25.11 atherosclerotic heart disease of native coronary artery with angina pectoris bleeding into the space between the surface of the brain, or pia mater, and the arachnoid, one of three coverings of the brain Grace Whah SAH https://www.uclahealth.org/neurosurgery/subarachnoid-hemorrhage I60 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I60-/I60 nontraumatic subarachnoid hemorrhage Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Grace Whah https://emedicine.medscape.com/article/1163977-overview#:~:text=Nontraumatic%20intracerebral%20hemorrhage%20most%20commonly,cold%20exposure)%2C%20rupture%20of%20an I61.9 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I61-/I61.9 nontraumatic intracerebral hemorrhage, unspecified A balloon-like buldge like causes a dissection (a tear in the lining of the aorta) Grace Whah https://www.mayoclinic.org/diseases-conditions/aortic-dissection/multimedia/aortic-dissection/img-20007636#:~:text=An%20aortic%20aneurysm%20occurs%20when,the%20image%20on%20the%20right. I71 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I70-I79/I71-/I71 aortic aneurysm and dissection A contagious respiratory illness that can cause mild to severe illness (fever, chills, aches) Grace Whah Flu https://www.cdc.gov/flu/about/index.html J09 Non-billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J09-/J09 influenza due to certain identified influenza viruses infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing. Grace Whah https://www.mayoclinic.org/diseases-conditions/pneumonia/symptoms-causes/syc-20354204#:~:text=Pneumonia%20is%20an%20infection%20that,and%20fungi%2C%20can%20cause%20pneumonia. J16.8 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18/J16-/J16.8 pneumonia due to other specified infectious organisms contagious viral infection caused by rhinovirus that causes inflammation of the bronchial tubes Grace Whah https://familydoctor.org/condition/acute-bronchitis/#:~:text=Acute%20bronchitis%20is%20a%20contagious,harder%20for%20you%20to%20breathe. J20.6 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J20-/J20.6 acute bronchitis due to rhinovirus inflammation of the stomach lining Grace Whah https://www.healthline.com/health/gastritis-chronic#:~:text=Chronic%20gastritis%20occurs%20when%20your,some%20of%20its%20protective%20cells. K29.5 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31/K29-/K29.5 unspecified chronic gastritis Diverticular disease consists of three conditions that involve the development of small sacs or pockets in the wall of the colon, including diverticulosis, diverticular bleeding, and diverticulitis. Grace Whah https://www.webmd.com/digestive-disorders/diverticular-disease#1 K57.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K57-/K57.3 diverticular disease of large intestine without perforation or abscess Disease of the anus or rectum Grace Whah https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K62-/K62 K62 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64/K62-/K62 other diseases of anus and rectum A disorder characterized by the inability of the liver to metabolize chemicals in the body. Grace Whah https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.9 K72.9 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K72-/K72.9 hepatic failure, unspecified Disease resulting in the inflammation of the liver Grace Whah https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K75-/K75.8 K75.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K75-/K75.8 Other specified inflammatory liver diseases Gallstones without inflammation of the gallbladder wall Grace Whah https://nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73556/all/Cholecystitis_and_Cholelithiasis K80.2 Non-billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87/K80-/K80.2 calculus of gallbladder without cholecystitis a blockage in the tubes that carry bile from the liver to the gallbladder and small intestine. Grace Whah https://www.mountsinai.org/health-library/diseases-conditions/bile-duct-obstruction#:~:text=Bile%20duct%20obstruction%20is%20a,into%20the%20duodenum%20for%20digestion. K83.1 Billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87/K83-/K83.1 obstruction of bile duct Bleeding from the gastric wall. Grace Whah https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.2 K92.2 Billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95/K92-/K92.2 gastrointestinal hemorrhage, unspecified A chronic disease of the skin marked by red patches covered with white scales. Grace Whah https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45/L40-/L40.9 L40.9 Billable https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45/L40-/L40.9 Psoriasis, unspecified a condition in which calcium pyrophosphate crystals build up in the knee Grace Whah CPPD https://www.verywellhealth.com/what-is-chondrocalcinosis-2552216#:~:text=Chondrocalcinosis%2C%20also%20known%20as%20calcium,and%20other%20types%20of%20arthritis. M11.26 Non-billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M11-/M11.26 other chondrocalcinosis, knee degeneration of the tissues of the hip joint, including hyaline cartilage, fibrocartilage, bone, and synovium Grace Whah OA https://journals.lww.com/jaaos/fulltext/2001/09000/primary_osteoarthritis_of_the_hip__etiology_and.5.aspx M16.0 Billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M15-M19/M16-/M16.0 bilateral primary osteoarthritis of hip A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg Grace Whah https://www.mayoclinic.org/diseases-conditions/sciatica/symptoms-causes/syc-20377435#:~:text=Sciatica%20occurs%20when%20the%20sciatic,a%20disease%20such%20as%20diabetes. M54.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54.3 Sciatica a painful condition that occurs when pressure within the muscles builds to dangerous levels. This pressure can decrease blood flow, which prevents nourishment and oxygen from reaching nerve and muscle cells Grace Whah https://orthoinfo.aaos.org/en/diseases--conditions/compartment-syndrome/#:~:text=Compartment%20syndrome%20is%20a%20painful,be%20either%20acute%20or%20chronic. M79 Non-billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M70-M79/M79-/M79.A Nontraumatic compartment syndrome An acute or chronic inflammatory process affecting the kidney. Grace Whah https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N12-/N12 N12 Billable https://www.icd10data.com/ICD10CM/Codes/N00-N99/N10-N16/N12-/N12 Tubulo-interstitial nephritis, not specified as acute or chronic Gestational diabetes is diabetes that happens for the first time when a woman is pregnant. Gestational diabetes goes away when you have your baby, but it does increase your risk for having diabetes later. Grace Whah https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.4 O24.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O20-O29/O24-/O24.4 Gestational diabetes mellitus irregular uterine contractions before the 37th week of pregnancy that mimick real labor Grace Whah Braxton hicks contractions https://my.clevelandclinic.org/health/articles/9686-true-vs-false-labor O47.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O30-O48/O47-/O47.0 False labor before 37 completed weeks of gestation preexisting anemia in a pregnant woman that complicates pregnancy and childbirth Grace Whah https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O94-O9A/O99-/O99.0 O99.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O94-O9A/O99-/O99.0 Anemia complicating pregnancy, childbirth and the puerperium A disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart. Grace Whah https://www.mayoclinic.org/diseases-conditions/heart-palpitations/symptoms-causes/syc-20373196 R00.2 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R00-/R00.2 Palpitations an acute bleeding from the lung, from the upper respiratory tract and the trachea, and the alveoli Grace Whah https://en.wikipedia.org/wiki/Pulmonary_hemorrhage#:~:text=Pulmonary%20hemorrhage%20(or%20pulmonary%20haemorrhage,the%20trachea%2C%20and%20the%20alveoli.&text=The%20onset%20of%20pulmonary%20hemorrhage,of%20oxygenation%20leading%20to%20cyanosis. R04 Non-billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R04-/R04 Hemorrhage from respiratory passages a decrease in your normal sensations in the skin such as touch or temperature Grace Whah https://www.healthline.com/health/what-is-hypoesthesia#causes R20.1 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R20-R23/R20-/R20.1 Hypoesthesia of skin A disorder characterized by lack of coordination of muscle movements Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R25-R29/R27-/R27.0 R27.0 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R25-R29/R27-/R27.0 ataxia, unspecified seeing things that aren't there Grace Whah https://www.sciencedirect.com/topics/neuroscience/visual-hallucination R44.1 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R40-R46/R44-/R44.1 visual hallucinations fluid accumulation that affects the whole body rather than particular organs or body areas. Grace Whah https://www.news-medical.net/health/Generalized-Edema.aspx#:~:text=Generalized%20edema%20refers%20to%20fluid,particular%20organs%20or%20body%20areas. R60.1 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R60-/R60.1 Generalized edema fracture or break in the upper end of the humerus Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42/S42.2-/S42.20 S42.20 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42/S42.2-/S42.20 unspecified fracture of upper end of humerus fracture in the anatomical portions of the femur which serve as the attachment sites for several muscles. Grace Whah https://radiopaedia.org/articles/isolated-greater-trochanteric-fracture-1?lang=us S72.11 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S70-S79/S72/S72.1-/S72.11 fracture of greater trochanter of femur complication occurs during procedure Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.8 T81.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T81-/T81.8 other complications of procedures, not elsewhere classified infection and/or inflammation resulting from the implanation of an internal device, implant, or graft Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.7 T85.7 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts application of an analog drug of cortisol that is used for its anti-inflammatory, immunosuppressive & antiproliferative effects Grace Whah http://tmedweb.tulane.edu/pharmwiki/doku.php/all_steroid_drugs#:~:text=Synthetic%20glucocorticoids%20are%20analogs%20of,commonly%20used%20synthetic%20compounds%20include%3A&text=This%20protects%20the%20fetus%20from%20high%20levels%20of%20these%20glucocorticoids. Y42.0 https://icd.who.int/browse10/2016/en#/Y42.0 glucocorticoids and synthetic analogues an occurance that requires attention to a tracheostomy procedure Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.0 Z43.0 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.0 encounter for attention to tracheostomy an occurance that requires attention to a gastrostomy procedure Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.1 Z43.1 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z40-Z53/Z43-/Z43.1 encounter for attention to gastrostomy Grace Whah K70 - K77 https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77 disease (process) of the liver Grace Whah C22 Malignant neoplasm of liver and intrahepatic bile ducts Grace Whah K80-K87 https://www.icd10data.com/ICD10CM/Codes/K00-K95/K80-K87 disease (process) of gallbladder, biliary tract and pancreas Grace Whah K20 - K31 https://www.icd10data.com/ICD10CM/Codes/K00-K95/K20-K31 disease (process) of esophagus, stomach and duodenum Grace Whah K55 - K64 https://www.icd10data.com/ICD10CM/Codes/K00-K95/K55-K64 other disease (process) of the intestines low amount of income (financial) Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.6 Z59.6 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.6 low income financial problems related to housing or general economic standing Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.9 Z59.9 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z55-Z65/Z59-/Z59.9 problem related to housing and economic circumstances, unspecified problems related to dependency on health care providers Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74 Z74 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z74-/Z74 problems related to care provider dependency other problems related to health care Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z75-/Z75.8 Z75.8 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z75-/Z75.8 other problems related to medical facilities and other health care history of cancerous tumors of the digestive organs Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.0 Z85.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.0 personal history of malignant neoplasm of digestive organs history of cancerous tumors of the lymphoid, hematopoietic and related tissues Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.7 Z85.7 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z85-/Z85.7 personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues patient refuses to follow medical treatment/regimen Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z91-/Z91.1 Z91.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z91-/Z91.1 patient's noncompliance with medical treatment and regimen an infection in the bloodstream that may travel to different body organs. Grace Whah https://medlineplus.gov/ency/article/001366.htm#:~:text=Septicemia%20is%20an%20infection%20in,usually%20does%20not%20cause%20infection. A40 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A40-/A40 streptococcal sepsis An acute infectious disorder of an unspecified site caused by gram positive or gram negative bacteria. Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49 A49 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49 bacterial infection of unspecified site An unspecified acute infectious disorder caused by gram positive or gram negative bacteria. Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49.9 A49.9 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/A30-A49/A49-/A49.9 bacterial infection, unspecified A condition in which candida albicans, a type of yeast, grows out of control in moist skin areas of the body Grace Whah Thrush https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37 B37 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B37-/B37 candidiasis Lung infections with the invasive forms of aspergillus Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B44-/B44.0 B44.0 Billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B35-B49/B44-/B44.0 invasive pulmonary aspergillosis diseases with bacteria (Streptococcus, Staphylococcus, and Enterococcus ) as the cause Grace Whah https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95 B95 Non-billable https://www.icd10data.com/ICD10CM/Codes/A00-B99/B95-B97/B95-/B95 Streptococcus, Staphylococcus, and Enterococcus as the cause of diseases classified elsewhere cancerous tumor of the brain Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C69-C72/C71-/C71 C71 Non-billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C69-C72/C71-/C71 malignant neoplasm of brain secondary cancerous tumor of the brain and cerebral meninges Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.3 C79.3 Non-billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C76-C80/C79-/C79.3 secondary malignant neoplasm of brain and cerebral meninges An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow; no remission Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.00 C91.00 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C81-C96/C91-/C91.00 acute lymphoblastic leukemia not having achieved remission a brain tumor that is currently benign but has characteristics that make it possible for the tumor to become malignant (cancerous) Grace Whah https://providers.amerigroup.com/Documents/ALL_CARE_CF_V3I12Neoplasms.pdf D49.6 Billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/D49-D49/D49-/D49.6 neoplasm of unspecified behavior of brain A disease where the blood clots throughout the body and increases the risk of bleeding Grace Whah https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D65-/D65 D65 Billable https://www.icd10data.com/ICD10CM/Codes/D50-D89/D65-D69/D65-/D65 disseminated intravascular coagulation [defibrination syndrome] an elevated uric acid level in the blood without symptoms of inflammatory arthritis and tophaceous disease Grace Whah https://en.wikipedia.org/wiki/Hyperuricemia#:~:text=Many%20factors%20contribute%20to%20hyperuricemia,consumption%20is%20the%20most%20important. E79.0 Billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E79-/E79.0 hyperuricemia without signs of inflammatory arthritis and tophaceous disease Abnormal increase in the volume of circulating fluid (plasma) in the body. Grace Whah https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.7 E87.7 Non-billable https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88/E87-/E87.7 fluid overload dependence on nicotine Grace Whah https://www.icd10data.com/ICD10CM/Codes/F01-F99/F10-F19/F17-/F17 F17 Non-billable https://www.icd10data.com/ICD10CM/Codes/F01-F99/F10-F19/F17-/F17 nicotine dependence a potentially serious sleep disorder in which the brain makes no effort to breathe for short periods of time https://www.mayoclinic.org/diseases-conditions/sleep-apnea/symptoms-causes/syc-20377631#:~:text=Sleep%20apnea%20is%20a%20potentially,occurs%20when%20throat%20muscles%20relax G47.31 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.31 primary central sleep apnea G40 - G47 https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47 sleep disorders stopping breathing for a period of time (apnea) due to high altitude Grace Whah https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.32 G47.32 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G40-G47/G47-/G47.32 high altitude periodic breathing unspecified disorder of the brain Grace Whah https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G93-/G93 G93 Non-billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G89-G99/G93-/G93 other disorders of brain A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I42-/I42 I42 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I30-I52/I42-/I42 cardiomyopathy Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Grace Whah https://emedicine.medscape.com/article/1163977-overview#:~:text=Nontraumatic%20intracerebral%20hemorrhage%20most%20commonly,cold%20exposure)%2C%20rupture%20of%20an I61 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I61-/I61 nontraumatic intracerebral hemorrhage diseases of the blood vessels in the brain Grace Whah https://en.wikipedia.org/wiki/Cerebrovascular_disease I67.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.8 other specified cerebrovascular diseases Grace Whah I60 - I69 https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69 cerebrovascular disease (process) rare conditions that result in obstruction of one or more arteries that supply blood to the brain Grace Whah https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/cerebrovascular/conditions/cerebrovascular_insufficiency.html#:~:text=Cerebrovascular%20insufficiency%20refers%20to%20a,or%20%22mini%20strokes%22). I67.81 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.81 acute cerebrovascular insufficiency A disorder characterized by a decrease or absence of blood supply to the brain Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.82 I67.82 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I67-/I67.82 cerebral ischemia when a blood clot develops in a blood vessel of the lower extremities and becomes stuck, obstructing blood flow Grace Whah https://www.healthline.com/health/thrombosis-vs-embolism#:~:text=Thrombosis%20occurs%20when%20a%20thrombus,obstructs%20the%20flow%20of%20blood. I82.81 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I80-I89/I82-/I82.81 embolism and thrombosis of superficial veins of lower extremities an acute inflammatory injury of the bronchioles that is usually caused by a viral infection Grace Whah https://emedicine.medscape.com/article/961963-overview#:~:text=Bronchiolitis%20is%20an%20acute%20inflammatory,seen%20in%20the%20image%20below. J21.9 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J20-J22/J21-/J21.9 acute bronchiolitis, unspecified complications/disorders of the respiratory system that occur during or after a procedure/operation Grace Whah https://www.icd10data.com/ICD10CM/Codes/J00-J99/J95-J95/J95-/J95 J95 Non-billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J95-J95/J95-/J95 intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified disease of the bronchus Grace Whah https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.0 J98.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J98-/J98.0 diseases of bronchus, not elsewhere classified respiratory disorder as a result of another disorder found elsewhere in the body Grace Whah https://icd.who.int/browse10/2016/en#/J99.8 J99.8 https://icd.who.int/browse10/2016/en#/J99.8 respiratory disorders in other diseases classified elsewhere any disturbance of liver function that causes illness. Grace Whah https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K76-/K76.9 K76.9 Billable https://www.icd10data.com/ICD10CM/Codes/K00-K95/K70-K77/K76-/K76.9 liver disease, unspecified A disorder characterized by marked pain in the back region. Grace Whah https://www.dorsalhealth.com/blog/what-is-dorsalgia-causes-treatment M54 Non-billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M50-M54/M54-/M54 dorsalgia a heart defect in which there are holes between the chambers of the right and left sides of the heart, and the valves that control the flow of blood between these chambers may not be formed correctly. Grace Whah AVSD https://www.cdc.gov/ncbddd/heartdefects/avsd.html#:~:text=An%20atrioventricular%20septal%20defect%20(AVSD,may%20not%20be%20formed%20correctly. Q21.2 Billable https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q20-Q28/Q21-/Q21.2 atrioventricular septal defect Grace Whah Q00 - Q99 https://www.icd10data.com/ICD10CM/Codes/Q00-Q99 congenital malformations, deformations and chromosomal abnormalities pain occuring in the throat and chest of the patient Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07 R07 Non-billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R00-R09/R07-/R07 pain in throat and chest inability or refusal to swallow. Grace Whah https://en.wikipedia.org/wiki/Aphagia#Causes R13.0 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R10-R19/R13-/R13.0 aphagia symptoms that have to do with food/fluid intake Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63 R63 Non-billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63 symptoms and signs concerning food and fluid intake difficulty feeding oneself Grace Whah https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.3 R63.3 Billable https://www.icd10data.com/ICD10CM/Codes/R00-R99/R50-R69/R63-/R63.3 feeding difficulties wound on head that is open Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S01-/S01 S01 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S00-S09/S01-/S01 open wound of head fracture or break on ribs, sternum and thoracic spine Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/S20-S29/S22-/S22 S22 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S20-S29/S22-/S22 fracture of rib(s), sternum and thoracic spine fracture or break on shoulder or upper arm Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42-/S42 S42 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/S40-S49/S42-/S42 fracture of shoulder and upper arm infection or inflammation due to the implementation of cardiac/vascular devices, implants, and grafts Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.7 T82.7 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.7 infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts other complications due to implementation of cardiac/vascular devices, implaces, grafts Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.8 T82.8 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T82-/T82.8 other specified complications of cardiac and vascular prosthetic devices, implants and grafts observation by doctors of suspected myocardial infarction (heart attack) Grace Whah https://www.icd10data.com/search?s=Z03.4 Z03.4 https://www.icd10data.com/search?s=Z03.4 observation for suspected myocardial infarction normal doctors appointment to ensure healthy supervised pregnancy Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z30-Z39/Z34-/Z34 Z34 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z30-Z39/Z34-/Z34 encounter for supervision of normal pregnancy healthy person (family, friend) staying with a sick patient Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z76-/Z76.3 Z76.3 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z69-Z76/Z76-/Z76.3 healthy person accompanying sick person other specified health condition/status not coded for Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z78-/Z78.9 Z78.9 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z78-/Z78.9 other specified health status history of infectious or parasitic diseases Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z86-/Z86.1 Z86.1 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z86-/Z86.1 personal history of infectious and parasitic diseases removal of organ (surgery/injury) Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z90-/Z90 Z90 Non-billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z90-/Z90 acquired absence of organs, not elsewhere classified patient has vascular implants/grafts Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.828 Z95.828 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z95-/Z95.828 presence of other vascular implants and grafts presence of breast implant Grace Whah https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z98-/Z98.82 Z98.8 Billable https://www.icd10data.com/ICD10CM/Codes/Z00-Z99/Z77-Z99/Z98-/Z98.82 breast implant status cancerous tumor on skin of lip Grace Whah https://www.icd10data.com/ICD10CM/Codes/C00-D49/C43-C44/C44-/C44.0 C44.0 Non-billable https://www.icd10data.com/ICD10CM/Codes/C00-D49/C43-C44/C44-/C44.0 other and unspecified malignant neoplasm of skin of lip A disorder affecting the cranial nerves or the peripheral nervous system. Grace Whah https://www.icd10data.com/ICD10CM/Codes/G00-G99/G60-G65/G62-/G62.9 G62.9 Billable https://www.icd10data.com/ICD10CM/Codes/G00-G99/G60-G65/G62-/G62.9 polyneuropathy, unspecified cognitive decline following cerebrovascular disease (disease of blood vessels in the brain) Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I69-/I69.91 I69.91 Non-billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I60-I69/I69-/I69.91 cognitive deficits following unspecified cerebrovascular disease A nonspecific hypersensitivity reaction caused by trauma causing pericardial effusion; high titers of anti-heart antibodies; low-grade fever; lethargy; loss of appetite; or abdominal pain. Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.0 I97.0 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.0 postcardiotomy syndrome heart muscle's pump function is reduced following heart surgery Grace Whah https://www.cardiosecur.com/magazine/specialist-articles-on-the-heart/cardiac-insufficiency-heart-failure#:~:text=Cardiac%20insufficiency%2C%20more%20commonly%20known,of%20blood%20throughout%20the%20body. I97.110 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.110 postprocedural cardiac insufficiency following cardiac surgery heart failure following heart surgery Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.130 I97.130 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.130 postprocedural heart failure following cardiac surgery general cardiac funciton abnormalities following heart surgery Grace Whah https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.190 I97.190 Billable https://www.icd10data.com/ICD10CM/Codes/I00-I99/I95-I99/I97-/I97.190 other postprocedural cardiac functional disturbances following cardiac surgery a condition that results in the inability to effectively exchange carbon dioxide and oxygen, and induces chronically low oxygen levels or chronically high carbon dioxide levels, unspecified which Grace Whah https://www.sciencedirect.com/topics/medicine-and-dentistry/chronic-respiratory-failure#:~:text=Chronic%20respiratory%20failure%20is%20a,chronically%20high%20carbon%20dioxide%20levels. J96.10 Billable https://www.icd10data.com/ICD10CM/Codes/J00-J99/J96-J99/J96-/J96.10 chronic respiratory failure, unspecified whether with hypoxia or hypercapnia a skin condition that causes a dark discoloration in body folds and creases. It typically affects the armpits, groin and neck. Grace Whah https://www.mayoclinic.org/diseases-conditions/acanthosis-nigricans/symptoms-causes/syc-20368983#:~:text=Acanthosis%20nigricans%20is%20a%20skin,affected%20skin%20can%20become%20thickened. L83 Billable https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L83-/L83 acanthosis nigricans injuries to skin on back and underlying tissue resulting from prolonged pressure on the skin. Grace Whah bedsores https://www.mayoclinic.org/diseases-conditions/bed-sores/symptoms-causes/syc-20355893 L89.10 Non-billable https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99/L89-/L89.10 pressure ulcer of unspecified part of back disease of the joints found in other diseases, multiple locations Grace Whah https://www.disnola.com/what-is-arthropathy/#:~:text=Arthropathy%20means%20any%20disease%20of,as%20rheumatoid%20arthritis%20and%20osteoarthritis. M14.89 Billable https://www.icd10data.com/ICD10CM/Codes/M00-M99/M05-M14/M14-/M14.89 arthropathies in other specified diseases classified elsewhere, multiple sites supervision of a pregnancy in a woman who has delivered 5 or more infants who has achieved a gestational age of 24+ weeks Grace Whah https://patient.info/doctor/gravidity-and-parity-definitions-and-their-implications-in-risk-assessment#:~:text=A%20grand%20multipara%20is%20a,pregnant%20five%20times%20or%20more. O09.4 Non-billable https://www.icd10data.com/ICD10CM/Codes/O00-O9A/O09-O09/O09-/O09.4 supervision of pregnancy with grand multiparity complication in mechanical design.function of internal and external prosthetic devices, implants and grafts Grace Whah https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.6 T85.6 Non-billable https://www.icd10data.com/ICD10CM/Codes/S00-T88/T80-T88/T85-/T85.6 mechanical complication of other specified internal and external prosthetic devices, implants and grafts cancerous tumor of the eye Grace Whah http://www.icd9data.com/2015/Volume1/140-239/190-199/190/190.htm?__hstc=93424706.0924cc95575484610bd29b86124947dc.1603072069548.1605584482533.1606196534170.7&__hssc=93424706.247.1606196534170&__hsfp=3629513924 190 Non-billable http://www.icd9data.com/2015/Volume1/140-239/190-199/190/190.htm?__hstc=93424706.0924cc95575484610bd29b86124947dc.1603072069548.1605584482533.1606196534170.7&__hssc=93424706.247.1606196534170&__hsfp=3629513924 malignant neoplasm of eye cancerous tumors within parts of the nervous system Grace Whah http://www.icd9data.com/2015/Volume1/140-239/190-199/192/192.htm?__hstc=93424706.0924cc95575484610bd29b86124947dc.1603072069548.1605584482533.1606196534170.7&__hssc=93424706.249.1606196534170&__hsfp=3629513924 192 Non-billable http://www.icd9data.com/2015/Volume1/140-239/190-199/192/192.htm?__hstc=93424706.0924cc95575484610bd29b86124947dc.1603072069548.1605584482533.1606196534170.7&__hssc=93424706.249.1606196534170&__hsfp=3629513924 malignant neoplasm of other and unspecified parts of nervous system a sample of tissue taken from the external ear in order to examine it more closely. Grace Whah https://www.webmd.com/cancer/what-is-a-biopsy#1 1812 https://www.hipaaspace.com/medical_billing/coding/icd-9/procedure/1812 external ear biopsy (Biopsy of external ear) a chronic metabolic disease characterized by structural and functional alterations and interstitial fibrosis without coronary artery disease or hypertension Grace Whah https://academic.oup.com/cardiovascres/article/113/4/389/3061106#:~:text=Metabolic%20cardiomyopathy%20is%20a%20chronic,coronary%20artery%20disease%20or%20hypertension. 4257 https://dexur.com/icd9/4257/ nutritional and metabolic cardiomyopathy Mucositis is painful inflammation or ulceration of the mucous membranes anywhere along the gastrointestinal tract. Stomatitis (oral mucositis) refers to inflammation and ulceration that occur in the mouth. Grace Whah https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743583/#:~:text=Mucositis%20is%20painful%20inflammation%20or,lips%2C%20and%20roof%20or%20floor. 5280 https://dexur.com/icd9/5280/ stomatitis and mucositis (ulcerative) Grace Whah chronic obstructive pulmonary disease (NEW) Grace Whah respiratory failure (NEW) Grace Whah respiratory infections (NEW) Grace Whah J09-J18 Influenza and pneumonia https://www.icd10data.com/ICD10CM/Codes/J00-J99/J09-J18 influeza and pneumonia (NEW) Grace Whah K00-K14 diseases of oral cavity and salivary glands https://www.icd10data.com/ICD10CM/Codes/K00-K95/K00-K14 diseases of oral cavity and salivary glands (NEW) Grace Whah K35-K38 diseases of appendix https://www.icd10data.com/ICD10CM/Codes/K00-K95/K35-K38 diseases of appendix (NEW) Grace Whah K40-K46 hernia https://www.icd10data.com/ICD10CM/Codes/K00-K95/K40-K46 hernia (NEW) Grace Whah K50-K52 noninfective enteritis and colitis https://www.icd10data.com/ICD10CM/Codes/K00-K95/K50-K52 noninfective enteritis and colitis (NEW) Grace Whah K65-K68 diseases of peritoneum and retroperitoneum https://www.icd10data.com/ICD10CM/Codes/K00-K95/K65-K68 diseases of peritoneum and retroperitoneum (NEW) Grace Whah K90-K95 other diseases of the digestive system https://www.icd10data.com/ICD10CM/Codes/K00-K95/K90-K95 other diseases of the digestive system (NEW) Grace Whah H00-H05 disorders of eyelid, lacrimal system and orbit https://www.icd10data.com/ICD10CM/Codes/H00-H59/H00-H05 disorders of eyelid, lacrimal system and orbit (NEW) Grace Whah H10-H11 disorders of conjunctiva https://www.icd10data.com/ICD10CM/Codes/H00-H59/H10-H11 disorders of conjunctiva (NEW) Grace Whah H15-H22 disorders of sclera, cornea, iris and ciliary body https://www.icd10data.com/ICD10CM/Codes/H00-H59/H15-H22 disorders of sclera, cornea, iris and ciliary body (NEW) Grace Whah H25-H28 disorders of lens https://www.icd10data.com/ICD10CM/Codes/H00-H59/H25-H28 disorders of lens (NEW) Grace Whah H30-H36 disorders of choroid and retina https://www.icd10data.com/ICD10CM/Codes/H00-H59/H30-H36 disorders of choroid and retina (NEW) Grace Whah H40-H42 glaucoma https://www.icd10data.com/ICD10CM/Codes/H00-H59/H40-H42 glaucoma (NEW) Grace Whah H43-H44 disorders of vitreous body and globe https://www.icd10data.com/ICD10CM/Codes/H00-H59/H43-H44 disorders of vitreous body and globe (NEW) Grace Whah H46-H47 disorders of optic nerve and visual pathways https://www.icd10data.com/ICD10CM/Codes/H00-H59/H46-H47 disorders of optic nerve and visual pathways (NEW) Grace Whah H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction https://www.icd10data.com/ICD10CM/Codes/H00-H59/H49-H52 disorders of ocular muscles, binocular movement, accommodation and refraction (NEW) Grace Whah H53-H54 visual disturbances and blindness https://www.icd10data.com/ICD10CM/Codes/H00-H59/H53-H54 visual disturbances and blindness (NEW) Grace Whah H55-H57 other disorders of eye and adnexa https://www.icd10data.com/ICD10CM/Codes/H00-H59/H55-H57 other disorders of eye and adnexa (NEW) Grace Whah H59-H59 intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified https://www.icd10data.com/ICD10CM/Codes/H00-H59/H59-H59 intraoperative and postprocedural complications and disorders of eye and adnexa, not elsewhere classified (NEW) Grace Whah I00-I02 acute rheumatic fever https://www.icd10data.com/ICD10CM/Codes/I00-I99/I00-I02 acute rheumatic fever (NEW) Grace Whah I05-I09 chronic rheumatic heart diseases https://www.icd10data.com/ICD10CM/Codes/I00-I99/I05-I09 chronic rheumatic heart diseases (NEW) Grace Whah I10-I16 hypertensive diseases https://www.icd10data.com/ICD10CM/Codes/I00-I99/I10-I16 hypertensive diseases (NEW) Grace Whah Q00-Q07 congential malformations of the nervous system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q00-Q07 congenital malformations of the nervous system (NEW) Grace Whah Q10-Q18 congenital malformations of eye, ear, face and neck https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q10-Q18 congenital malformations of eye, ear, face and neck (NEW) Grace Whah Q20-Q28 congenital malformations of the circulatory system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q20-Q28 congenital malformations of the circulatory system (NEW) Grace Whah Q30-Q34 congenital malformations of the respiratory system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q30-Q34 congenital malformations of the respiratory system (NEW) Grace Whah Q35-Q37 cleft lip and cleft palate https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q35-Q37 cleft lip and cleft palate (NEW) Grace Whah Q38-Q45 other congenital malformations of the digestive system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q38-Q45 other congenital malformations of the digestive system (NEW) Grace Whah Q50-Q56 congenital malformations of genital organs https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q50-Q56 congenital malformations of genital organs (NEW) Grace Whah Q60-Q64 congenital malformations of the urinary system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q60-Q64 congenital malformations of the urinary system (NEW) Grace Whah Q65-Q79 congenital malformations and deformations of the musculoskeletal system https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q65-Q79 congenital malformations and deformations of the musculoskeletal system (NEW) Grace Whah Q80-Q89 other congenital malformations https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q80-Q89 other congenital malformations (NEW) Grace Whah Q90-Q99 chromosomal abnormalities, not elsewhere classified https://www.icd10data.com/ICD10CM/Codes/Q00-Q99/Q90-Q99 chromosomal abnormalities, not elsewhere classified (NEW) Grace Whah L00-L08 infections of the skin and subcutaneous tissue https://www.icd10data.com/ICD10CM/Codes/L00-L99/L00-L08v infections of the skin and subcutaneous tissue (NEW) Grace Whah L10-L14 bullous disorders https://www.icd10data.com/ICD10CM/Codes/L00-L99/L10-L14 bullous disorders (NEW) Grace Whah L20-L30 dermatitis and eczema https://www.icd10data.com/ICD10CM/Codes/L00-L99/L20-L30 dermatitis and eczema (NEW) Grace Whah L40-L45 papulosquamous disorders https://www.icd10data.com/ICD10CM/Codes/L00-L99/L40-L45 papulosquamous disorders (NEW) Grace Whah L49-L54 urticaria and erythema https://www.icd10data.com/ICD10CM/Codes/L00-L99/L49-L54 urticaria and erythema (NEW) Grace Whah L55-L59 radiation-related disorders of the skin and subcutaneous tissue https://www.icd10data.com/ICD10CM/Codes/L00-L99/L55-L59 radiation-related disorders of the skin and subcutaneous tissue (NEW) Grace Whah L60-L75 disorders of skin appendages https://www.icd10data.com/ICD10CM/Codes/L00-L99/L60-L75 disorders of skin appendages (NEW) Grace Whah L76-L76 intraoperative and postprocedural complications of skin and subcutaneous tissue https://www.icd10data.com/ICD10CM/Codes/L00-L99/L76-L76 intraoperative and postprocedural complications of skin and subcutaneous tissue (NEW) Grace Whah L80-L99 other disorders of the skin and subcutaneous tissue https://www.icd10data.com/ICD10CM/Codes/L00-L99/L80-L99 other disorders of the skin and subcutaneous tissue (NEW) Grace Whah E00-E89 https://www.icd10data.com/ICD10CM/Codes/E00-E89 endocrine, nutritional and metabolic diseases (NEW) Grace Whah E00-E07 disorders of thyroid gland https://www.icd10data.com/ICD10CM/Codes/E00-E89/E00-E07 disorders of thyroid gland (NEW) Grace Whah E08-E13 diabetes mellitus https://www.icd10data.com/ICD10CM/Codes/E00-E89/E08-E13 diabetes mellitus (NEW) Grace Whah E15-E16 other disorders of glucose regulation and pancreatic internal secretion https://www.icd10data.com/ICD10CM/Codes/E00-E89/E15-E16 other disorders of glucose regulation and pancreatic internal secretion (NEW) Grace Whah E20-E35 disorders of other endocrine glands https://www.icd10data.com/ICD10CM/Codes/E00-E89/E20-E35 disorders of other endocrine glands (NEW) Grace Whah E36-E36 Intraoperative complications of endocrine system https://www.icd10data.com/ICD10CM/Codes/E00-E89/E36-E36 intraoperative complications of endocrine system (NEW) Grace Whah E40-E46 Malnutrition https://www.icd10data.com/ICD10CM/Codes/E00-E89/E40-E46 malnutrition (NEW) Grace Whah E50-E64 Other nutritional deficiencies https://www.icd10data.com/ICD10CM/Codes/E00-E89/E50-E64 other nutritional deficiencies (NEW) Grace Whah E65-E68 Overweight, obesity and other hyperalimentation https://www.icd10data.com/ICD10CM/Codes/E00-E89/E65-E68 overweight, obesity and other hyperalimentation (NEW) Grace Whah E70-E88 Metabolic disorders https://www.icd10data.com/ICD10CM/Codes/E00-E89/E70-E88 metabolic disorders (NEW) Grace Whah E89-E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified https://www.icd10data.com/ICD10CM/Codes/E00-E89 postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (NEW) H60.300 H60.3 other infective otitis externa DP 感染性外耳炎，其他的 H60.400 H60.4 cholesteatoma of external ear cholesteatoma of external ear DP 外耳胆脂瘤 H61.100 H61.1 noninfective disorders of pinna noninfective DP of pinna 耳郭非感染性疾患病程 H61.800 H61.8 other specified disorders of external ear DP 外耳其他特指的疾患 H62 disorders of external ear in diseases classified elsewhere DP 分类于他处的的外耳疾患 A46† H62.0 Otitis externa in erysipelas otitis externa in bacterial diseases classified elsewhere DP B00.1† B02.8† Otitis externa in herpesviral [herpes simplex] infection H62.1 Otitis externa in zoster otitis externa in viral diseases classified elsewhere DP B36.9† B37.2† B44.8† H62.2 otitis externa in mycoses Otitis externa in aspergillosis Otitis externa in candidiasis Otomycosis NOS otitis externa in mycoses DP 真菌性外耳炎 H62.3 otitis externa in other infectious and parasitic diseases classified elsewhere DP H62.4 L01.-† Otitis externa in impetigo otitis externa in other diseases classified elsewhere DP H62.8 other disorders of external ear in diseases classified elsewhere DP 1B70.01 erysipelas of external ear erysipelas of external ear DP 外耳丹毒 1F20.10 aspergillus otomycosis  aspergillus otomycosis DP 曲霉菌真菌病 1F23.16  candida otomycosis candida otomycosis DP 念珠菌属真菌病 H60.100 AA01 H60.1 cellulitis of external ear cellulitis of external ear DP 外耳蜂窝织炎病程 H60.200 AA02 H60.2 malignant otitis externa malignant otitis externa DP 恶性外耳炎 AA03  otomycosis otomycosis DP 耳真菌病 H61.000 AA04 H61.0 perichondritis of external ear perichondritis of external ear DP 外耳软骨膜炎 AA0Y  other specified infectious diseases of external ear DP 其他特指的外耳感染 AA0Z  Infectious diseases of external ear, unspecified Infectious DP of external ear, unspecified 耳廓感染，未特指的 AA10  seborrhoeic otitis externa DP seborrhoeic otitis externa DP 外耳脂溢性皮炎 H60.500 AA11 H60.5 acute noninfectious otitis externa acute otitis externa, noninfective DP acute noninfectious otitis externa DP 急性非感染性耳炎 AA12 chondrodermatitis nodularis chondrodermatitis nodularis DP 结节性软骨皮炎病程 H60.801 AA13 chronic otitis externa chronic otitis externa DP 慢性外耳炎 AA1Y  other specified noninfectious inflammation of external ear DP 其他特指的非感染性外耳炎症 AA1Z Noninfectious inflammation of external ear, unspecified Noninfectious inflammation of external ear, unspecified DP 外耳非感染性炎症，未特指的 AA3Z  otitis externa, unspecified otitis externa, unspecified DP 外耳炎，未特指的 AA40 acquired deformity of external auditory canal acquired deformity of external auditory canal DP 获得性外耳道畸形 H61.802 AA40.0 H61.8 exostosis of external canal exostosis of external canal DP 外耳道外生骨疣 H61.300 AA40.1 H61.3 acquired stenosis of external auditory canal acquired stenosis of external auditory canal DP 后天性外耳道狭窄 AA40.2 H60.4  cholesteatoma of external auditory canal cholesteatoma of external auditory canal DP 外耳道胆脂瘤 AA40.Y other specified acquired deformity of external auditory canal DP 其他特指的获得性外耳道畸形 AA41  acquired deformity of pinna 后天性耳廓畸形 acquired deformity of pinna DP 获得性耳廓畸形 Cauliflower ear AA41.0  cauliflower ear DP 菜花耳 AA41.Y  other specified acquired deformity of pinna DP 其他特指的获得性耳廓畸形 H61.200 AA42 H61.2 impacted cerumen impacted cerumen DP 耵聍栓塞 AA4Y other specified noninflammatory disorders of the external ear DP 其他特指的外耳非感染性疾患 AA4Z noninflammatory disorders of the external ear, unspecified noninflammatory DP of the external ear, unspecified 外耳非感染性疾患，未特指的 H61.900 AA6Z  H61.9 diseases of external ear, unspecified external ear, unspecified DP 耳廓疾病病程，未特指的 EE60.00 ear-lobe keloid ear-lobe keloid DP 耳垂瘢痕瘤病程 EG40  contact dermatitis of external ear contact dermatitis of external ear DP 外耳接触性皮炎 H60.401 granuloma of external ear granuloma of external ear DP 外耳肉芽肿 H60.402 obstructive keratosis of external ear obstructive keratosis of external ear DP 外耳阻塞性角化病程 H61.806 external ear canal cyst external ear canal cyst DP 外耳道囊肿 H60.301 hemorrhagic otitis externa hemorrhagic otitis externa DP 出血性外耳炎 H60.302 diffuse otitis externa diffuse otitis externa DP 弥漫性外耳炎 H60.303 swimmer's ear beach ear DP swimmer's ear DP 游泳者耳病 H60.403 granuloma of external ear canal granuloma of external ear canal DP 外耳道肉芽肿 H60.501 H60.54 acute eczematoid otitis externa acute eczematoid otitis externa DP 外耳湿疹 H60.502 H60.51 acute actinic otitis externa acute actinic otitis externa DP 急性光化性外耳炎 H60.503 H60.52 acute chemical otitis externa acute chemical otitis externa DP 急性化学性外耳炎 H61.001 chondrodermatitis nodularis chronica helicis chondrodermatitis nodularis chronica helicis DP 慢性结节性耳轮软骨皮炎 H61.002 pinna scar pinna scar DP 耳郭瘢痕病程 H61.101 acquired deformity of external ear acquired deformity of external ear DP 后天性外耳畸形 H61.103 pinna pseudocyst pinna pseudocyst DP 耳郭假性囊肿 H61.104 hematoma ossification behind ear hematoma ossification behind ear DP 耳后血肿骨化 H61.105 pinna tumor pinna tumor DP 耳郭肿物 H61.801 temporomandibular joint external ear canal   hernia temporomandibular joint external ear canal   hernia DP 颞下颌关节外耳道疝 H61.803 external ear fistula external ear fistula DP 外耳瘘 H61.804 external ear canal keratosis external ear canal keratosis DP 外耳道角化症病程 H61.805 external ear canal necrosis external ear canal necrosis DP 外耳道坏死 H61.901 external ear canal tumor external ear canal tumor DP 外耳道肿物 H61.902 acquired external ear canal atresia acquired external ear canal atresia DP 后天性外耳道闭锁 A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. disease Albert Goldfain creation date: 2009-06-23T11:53:49Z bodily process A bodily process that is clinically abnormal. Albert Goldfain http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf creation date: 2009-06-23T11:54:29Z pathological bodily process A pathological bodily process in which a canonical anatomical structure becomes a pathological anatomical structure. Albert Goldfain http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf creation date: 2009-07-13T02:17:07Z pathological transformation A pathological bodily process in which matter is reorganized in such a way as to give rise to new pathological formations which take the place of entities existing earlier. Albert Goldfain http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf creation date: 2009-07-13T02:17:24Z pathological derivation TODO: Define. Albert Goldfain http://ontology.buffalo.edu/bio/ISMB/ISMB_Bio-ontologies.pdf creation date: 2009-07-13T02:17:47Z pathological invasion quality (PATO) quality A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. quality PATO:0000051 morphology 形态学的 A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. PATO:0001452 conformation relational structural quality quality PATO:0000141 structure 结构性 A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course. quality PATO:0000389 acute 急性 A quality which inheres in an process. PATO:0001239 PATO:0001240 quality of a process quality of occurrent quality of process relational quality of occurrent quality PATO:0001236 See comments of relational quality of a physical entity. process quality A quality which inheres in a continuant. PATO:0001237 PATO:0001238 snap:Quality monadic quality of a continuant multiply inhering quality of a physical entity quality of a continuant quality of a single physical entity quality of an object quality of continuant monadic quality of an object monadic quality of continuant quality PATO:0001241 Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. physical object quality A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point. PATO:0000081 period quality time PATO:0001309 duration A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically. PATO:0001837 stenosis stenotic stricture quality PATO:0001847 constricted constricted 狭窄的 A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration. quality PATO:0001863 chronic 慢性 A structural quality inhering in a bearer by virtue of the bearer's touching another entity. quality