format-version: 1.2
data-version: releases/2025-03-18
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subsetdef: 2_STAR ""
subsetdef: 3_STAR ""
subsetdef: abnormal_slim ""
subsetdef: absent_slim ""
subsetdef: added_for_HCA ""
subsetdef: AISM:0000171 ""
subsetdef: attribute_slim ""
subsetdef: blood_and_immune_upper_slim ""
subsetdef: cell_quality ""
subsetdef: cellxgene_subset ""
subsetdef: common_anatomy ""
subsetdef: cumbo ""
subsetdef: developmental_classification ""
subsetdef: disposition_slim ""
subsetdef: early_development ""
subsetdef: efo_slim ""
subsetdef: emapa_ehdaa2 ""
subsetdef: eye_upper_slim ""
subsetdef: functional_classification ""
subsetdef: general_cell_types_upper_slim ""
subsetdef: gocheck_do_not_annotate ""
subsetdef: gocheck_do_not_manually_annotate ""
subsetdef: goslim_agr ""
subsetdef: goslim_candida ""
subsetdef: goslim_chembl ""
subsetdef: goslim_drosophila ""
subsetdef: goslim_flybase_ribbon ""
subsetdef: goslim_generic ""
subsetdef: goslim_metagenomics ""
subsetdef: goslim_mouse ""
subsetdef: goslim_pir ""
subsetdef: goslim_plant ""
subsetdef: goslim_pombe ""
subsetdef: goslim_prokaryote ""
subsetdef: goslim_synapse ""
subsetdef: goslim_yeast ""
subsetdef: grouping_class ""
subsetdef: homology_grouping ""
subsetdef: hpo_slim ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_annotation_extension ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_gp2term ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_go_ontology ""
subsetdef: http://purl.obolibrary.org/obo/valid_for_gocam ""
subsetdef: human_reference_atlas ""
subsetdef: human_subset ""
subsetdef: inconsistent_with_fma ""
subsetdef: kidney_upper_slim ""
subsetdef: location_grouping ""
subsetdef: major_organ ""
subsetdef: mouse_subset ""
subsetdef: mpath_slim ""
subsetdef: non_informative ""
subsetdef: organ_slim ""
subsetdef: pheno_slim ""
subsetdef: phenotype_rcn ""
subsetdef: relational_slim ""
subsetdef: ro-eco ""
subsetdef: RO:0002259 ""
subsetdef: scalar_slim ""
subsetdef: uberon_slim ""
subsetdef: ubprop:upper_level ""
subsetdef: unverified_taxonomic_grouping ""
subsetdef: upper_level ""
subsetdef: value_slim ""
subsetdef: vertebrate_core ""
synonymtypedef: blast_name ""
synonymtypedef: DEPRECATED ""
synonymtypedef: equivalent_name ""
synonymtypedef: genbank_common_name ""
synonymtypedef: Gene-based ""
synonymtypedef: human ""
synonymtypedef: HUMAN_PREFERRED ""
synonymtypedef: in_part ""
synonymtypedef: INCONSISTENT ""
synonymtypedef: INN ""
synonymtypedef: IUPAC_NAME ""
synonymtypedef: OMO:0003000 ""
synonymtypedef: OMO:0003002 ""
synonymtypedef: OMO:0003003 ""
synonymtypedef: OMO:0003004 ""
synonymtypedef: OMO:0003011 ""
synonymtypedef: PENDING_REVIEW ""
synonymtypedef: PRO-short-label ""
synonymtypedef: scientific_name ""
synonymtypedef: SENSU ""
synonymtypedef: syngo_official_label ""
synonymtypedef: synonym ""
synonymtypedef: systematic_synonym ""
synonymtypedef: vertebrate ""
idspace: cito http://purl.org/spar/cito/ 
idspace: doap http://usefulinc.com/ns/doap# 
idspace: obo1 http://www.geneontology.org/formats/oboInOwl#http://purl.obolibrary.org/obo/ 
idspace: oboI http://www.geneontology.org/formats/oboInOwl# 
idspace: oboInOwl ttp://www.geneontology.org/formats/oboInOwl# 
idspace: protege http://protege.stanford.edu/plugins/owl/protege# 
idspace: skos http://www.w3.org/2004/02/skos/core# 
idspace: sssom https://w3id.org/sssom/ 
idspace: swrl http://www.w3.org/2003/11/swrl# 
idspace: swrla http://swrl.stanford.edu/ontologies/3.3/swrla.owl# 
idspace: swrlb http://www.w3.org/2003/11/swrlb# 
idspace: term http://purl.org/dc/terms/ 
idspace: terms http://www.geneontology.org/formats/oboInOwl#http://purl.org/dc/terms/ 
idspace: vocab https://w3id.org/semapv/vocab/ 
idspace: x_0.1 http://xmlns.com/foaf/0.1/ 
idspace: x_1.1 http://purl.org/dc/elements/1.1/ 
ontology: aism
property_value: dc-description "The ontology for the Anatomy of the Insect SkeletoMuscular system (AISM) contains terms used to describe the cuticle - as a single anatomical structure - and the skeletal muscle system, to be used in insect biodiversity research." xsd:string
property_value: dc-title "Ontology for the Anatomy of the Insect SkeletoMuscular system" xsd:string
property_value: dcterms-license https://creativecommons.org/licenses/by/4.0/
property_value: has_ontology_root_term "http://purl.obolibrary.org/obo/AISM_0000174" xsd:string
property_value: has_ontology_root_term "http://purl.obolibrary.org/obo/PATO_0000001" xsd:string
property_value: has_ontology_root_term "http://purl.obolibrary.org/obo/UBERON_0001062" xsd:string
property_value: owl:versionInfo "2025-03-18" xsd:string
property_value: x_1.1:contributor "Giulio Montanaro (gmontanaro) https://orcid.org/0000-0003-0836-1364" xsd:string
property_value: x_1.1:contributor "István Mikó (imiko) https://orcid.org/0000-0003-2938-9075" xsd:string
property_value: x_1.1:contributor "Jennifer C. Girón (jgiron) https://orcid.org/0000-0002-0851-6883" xsd:string
property_value: x_1.1:contributor "Luis A. González Montaña (lagonzalezmo) https://orcid.org/0000-0002-9136-9932" xsd:string
property_value: x_1.1:contributor "Sergei Tarasov (starasov) https://orcid.org/0000-0001-5237-2330" xsd:string

[Term]
id: AISM:0000000
name: cuticular internal depression
def: "The projection of the inner surface of the cuticle." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-05-19"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
relationship: has_characteristic PATO:0001857 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! concave
relationship: part_of BSPO:0000061 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! proximal side

[Term]
id: AISM:0000001
name: resilin {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
def: "Resilin is an elastomeric protein found in many insects and other arthropods. It provides soft rubber-elasticity to mechanically active organs and tissue.\nhttps://en.wikipedia.org/wiki/Resilin" [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
is_a: PR:000000001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! protein
property_value: curator_notes "This is a generalized term to refer to this protein as the only option available now is pro-resilin (fruit fly) [http://purl.obolibrary.org/obo/PR_Q9V7U0]" xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}

[Term]
id: AISM:0000002
name: insect articulation
def: "The region of cuticle that is composed two articular surfaces that are adjacent to each other." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
property_value: curator_notes "Articulations are 'anatomical clusters', collections of not direclty connected (continuous) sclerite surfaces that are adjacent to another sclerite. The cranio-mandibular articulation is the articular surface of the cranium and the adjacent articular surface of the mandible. The articular surfaces are sometimes located on the same sclerite." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}

[Term]
id: AISM:0000003
name: insect sclerite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sclerite: distinctly sclerotized region of the integument, with thick layer of exocuticle.\"", IAO:0000232="Modified 2023-01-09: specifying insect sclerite.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The region of the insect cuticle that is less flexible than the neighboring conjunctiva(e) (conjunctiva(e) that the sclerite is continuous with." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
xref: http://flybase.org/cgi-bin/fbcvq.html?query=FBbt\:00004475 "sclerite"
xref: http://purl.obolibrary.org/obo/HAO_0000909 "sclerite" {def="The area of the cuticle that is less flexible than adjacent conjunctivae."}
xref: http://purl.obolibrary.org/obo/UBERON_6004475 "insect sclerite"
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
property_value: IAO:0000118 "esclerito" xsd:string {creation_date="2023-01-09"}

[Term]
id: AISM:0000004
name: conjunctiva
def: "The region of the insect cuticle that is more flexible than the neighboring sclerite(s) [sclerite(s) that the conjunctiva is continuous with]." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
synonym: "membrane" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Membrane: very flexible, unsclerotized area of the integument.\""}
xref: http://purl.obolibrary.org/obo/HAO_0000221 "conjunctiva" {def="The area of the cuticle that is more flexible than adjacent sclerites."}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
relationship: continuous_with AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
property_value: curator_notes "Conjunctivae are more flexible and usually less thick than sclerties of the cuticle allowing the sclerites to move relative to each other.\nMicro-CT based methods cannot be used to accurately differentiate slcerites from conjunctiuvae. CLSM (the excitation wavelengths of sclerites and conjunctivae are different in response of 488 nm emission vawelength), histological sections or simple dissections need to be applied to define relative flexibility of the insect cuticle.\n\nIf a conjunctiva entirelly encircles a sclerite, then the 'encircles' and 'encircled by' object properties are used to link the sclerite and the conjunctiva even in cases in which the encircled sclerites or conjunctivae are part of an evagination allowing to model spatial relationship between appendage segments: the pedicel is encircled by the scapal-pedicellar conjunctiva, which is encircled by the scape or the the coxa encircles the coxo-femoral conjunctiuva that encircels the femur." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}

[Term]
id: AISM:0000005
name: cuticular depression
def: "The region of the cuticle that corresponds to a concave surface." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: BFO:0000004 ! independent continuant
relationship: has_characteristic PATO:0001857 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! concave
relationship: in_distal_side_of AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
property_value: curator_notes "External cuticular depression. The surface of the cuticle in insects is the entire surface of an organism, and it is composed of flat, concave and convex regions. Concavities sometimes correspons with invaginations of the cuticle and the underlaying sinlge layer epidermis, somtimes correspond to a decreased cuticular thickness." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}

[Term]
id: AISM:0000006
name: cuticular invagination
def: "The region of cuticle that corresponds with an invagination of the single layer epidermis (epidermal fold). The cuticular invagination sometimes corresponds to a cuticular depression (concavity on the surface of the cuticle)." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
relationship: RO:0002008 AISM:0000000 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with cuticular internal depression
relationship: RO:0002008 AISM:0000005 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with cuticular depression

[Term]
id: AISM:0000007
name: elastic cuticle {creation_date="2020-10-27"}
def: "The region of cuticle with higher content of resilin." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
is_a: PR:000050567 ! protein-containing material entity
relationship: composed_primarily_of AISM:0000001 {IAO:0000232="Modified 2024-02-14: updated to 'composed primarily of' and linked to resilin\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! resilin

[Term]
id: AISM:0000008
name: cuticular protrusion
def: "The region of the cuticle that corresponds to a convex surface." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
relationship: has_characteristic PATO:0001355 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! convex
relationship: part_of BSPO:0000062 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! distal side
property_value: curator_notes "The surface of the cuticle in insects is the entire surface of an organism, and it is composed of flat, concave and convex regions. Convexities sometimes correspons with evaginations of the cuticle and the underlaying sinlge layer epidermis and sometimes correspond to an increased cuticular thickness.\"" xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}

[Term]
id: AISM:0000009
name: cuticular fossa {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
def: "The cuticular depression that is adjacent to a cuticular condyle." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
is_a: AISM:0000005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! cuticular depression
relationship: adjacent_to AISM:0000010 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! cuticular condyle

[Term]
id: AISM:0000010
name: cuticular condyle {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
def: "The cuticular protrusion that is part of an insect sclerite and adjacent to an articular surface." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
is_a: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! cuticular protrusion
relationship: adjacent_to AISM:0000167 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! articular surface
relationship: part_of AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! insect sclerite

[Term]
id: AISM:0000013
name: evaginated {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
def: "A part or structure that is produced by evagination." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: PATO:0001355 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! convex

[Term]
id: AISM:0000014
name: insect cranio-mandibular articulation {IAO:0000232="Modified 2023-02-05: specified insect.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The articulation between the mandible and the cranium." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect articulation

[Term]
id: AISM:0000015
name: cranio-cardinal articulation
def: "The articulation between the cardo and the cranium." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect articulation

[Term]
id: AISM:0000016
name: cranio-antennal articulation
def: "The articulation between the scapus and the cranium." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect articulation

[Term]
id: AISM:0000017
name: insect head-cervical articulation {IAO:0000232="Modified 2023-02-05: specified insect.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The articulation between the head and the neck." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-10-27"}
is_a: AISM:0000002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect articulation

[Term]
id: AISM:0000018
name: cardo {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Cardo: basal element of maxilla, articulating with head capsule; usually moved by one cranial muscle and one tentorial muscle.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The sclerite of the insect maxilla that is attached to the head capsule by the oral foraminal conjunctiva and to the cuticle of stipes by the stipito-cardinal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: adjacent_to AISM:0000111 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! stipes
relationship: continuous_with AISM:0000099 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! oral foraminal conjunctiva
relationship: continuous_with AISM:0000110 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cardo-stipital conjunctiva
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla
property_value: IAO:0000589 "cuticle of cardo" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000019
name: head capsule {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"The head capsule is almost always a rigid, well sclerotized structural unit, equipped with a defined set of appendages. It is reinforced by strengthening ridges and the endoskeletal tentorium\""}
def: "The sclerite of the insect head that is attached to the neck membrane and the oral foraminal conjunctiva, bears the eye cuticle and surrounds the brain" [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
synonym: "cephalic capsule" EXACT [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "insect cranium" EXACT [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: AISM:0000078 AISM:0000099 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles oral foraminal conjunctiva
relationship: continuous_with AISM:0000098 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! neck membrane
relationship: has_part AISM:0000088 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! eye cuticle
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head
relationship: surrounds UBERON:0000955 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! brain

[Term]
id: AISM:0000020
name: dorsal second axillary sclerite
def: "The axillary sclerite that is on the dorsal region of the basal wing conjunctiva and lateral to the first axillary sclerite." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! axillary sclerite
relationship: AISM:0000011 AISM:0000022 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! lateral_to first axillary sclerite

[Term]
id: AISM:0000021
name: abdominal tergite I
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the tergum by the metanoto-abdominal tergite I conjunctiva." [] {IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004082 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanoto-abdominal tergite I conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0000022
name: first axillary sclerite
def: "The axillary sclerite that is part of the dorsal region of the basal wing conjunctiva and is anterior to the third axillary sclerite." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! axillary sclerite
relationship: anterior_to AISM:0004223 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! third axillary sclerite

[Term]
id: AISM:0000023
name: galea {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Galea: outer endite lobe of maxilla, usually semimembranous and equipped with sensilla (mainly chemoreceptors).\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the insect maxilla that is attached to the stipes by the stipito-galeal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect appendage
relationship: adjacent_to AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: continuous_with AISM:0004011 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-galeal conjunctiva
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla
property_value: IAO:0000589 "cuticle of galea" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000024
name: labial palpus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Labial palp: tactile appendage of the labium.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the labium that is attached to the palpiger by the palpigero-palpal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: adjacent_to AISM:0004006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpiger
relationship: AISM:0000079 AISM:0004017 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by palpigero-palpal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium
property_value: IAO:0000589 "cuticle of labial palpus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000026
name: lacinia {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Lacinia: inner endite lobe of maxilla, usually firmly connected or fused with stipes; usually sclerotized, with mesally curved apex and articulated spines arranged along mesal edge.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the insect maxilla that is attached to the cuticle of stipes by the stipito-lacinial conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect appendage
relationship: adjacent_to AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: continuous_with AISM:0004009 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-lacinial conjunctiva
relationship: part_of AISM:0000044 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect maxilla
property_value: IAO:0000589 "cuticle of lacinia" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000027
name: cuticular evagination
def: "The region of cuticle that corresponds with an evagination of the cuticle and the single layer epidermis (epidermal fold). The cuticular evagination usually corresponds to a cuticular protrusion (convexity on the surface of the cuticle)." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000008 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular protrusion
intersection_of: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! cuticular protrusion
intersection_of: has_characteristic AISM:0000013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! evaginated
intersection_of: RO:0002008 UBERON:0005157 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! coincident with epithelial fold
relationship: has_characteristic AISM:0000013 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! evaginated
relationship: RO:0002008 UBERON:0005157 {creation_date="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epithelial fold

[Term]
id: AISM:0000028
name: solid cuticular protrusion {creation_date="2020-11-11"}
def: "The cuticular protrusion that does not correspond to an evagination." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000008 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular protrusion

[Term]
id: AISM:0000029
name: insect appendage {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"any part, piece, or organ attached by a joint to the body or to any other main structure\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The evagination of the cuticle that is musculated (connected to the body via muscles)." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! multicellular cuticular evagination
intersection_of: AISM:0000128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! multicellular cuticular evagination
intersection_of: continuous_with UBERON:0014895 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! somatic muscle
relationship: continuous_with UBERON:0014895 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! somatic muscle
property_value: IAO:0000589 "cuticle of insect appendage" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000031
name: insect leg {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the insect thorax that is composed of coxa, trochanter, femur, tibia, tarsus, and pretarsus." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect appendage
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: has_part AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: has_part AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibia
relationship: has_part AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femur
relationship: has_part AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: has_part AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter
relationship: has_part AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsus
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax
property_value: IAO:0000589 "cuticle of insect leg" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000032
name: antenna {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Antenna: head appendage of segment 2, innervated by deutocerebrum; in Insecta composed of scapus, pedicellus and flagellum; primarily multisegmented and filiform.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the head capsule that is connected by the  antenniferal-scapal conjunctiva to the cuticle of the scapus, which is connected by the scapal-pedicellar conjunctiva to the cuticle of the pedicellus; the cuticle of the pedicellus is connected by the pedicellar-first flagellomeral conjunctiva to the cuticle of the first flagellomere; the cuticle of the first flagellomere is connected by interflagellomeral conjunctiva to the next cuticle of flagellomere. Further cuticle of flagellomeres are connected to each other by interflagellomeral conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: AISM:0000079 AISM:0004007 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by antenniferal-scapal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: has_part AISM:0000113 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! scapus
relationship: has_part AISM:0000114 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! scapal-pedicellar conjunctiva
relationship: has_part AISM:0000115 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pedicellus
relationship: has_part AISM:0000117 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! flagellomere 1
relationship: has_part AISM:0000118 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pedicellar-first flagellomeral conjunctiva
relationship: has_part AISM:0004008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! interflagellomeral conjunctiva
relationship: part_of UBERON:6003007 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect adult head
property_value: IAO:0000589 "cuticle of antenna" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000033
name: insect wing {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"in adult insects or subimago of Ephemeroptera, paired mambranous appendages, supported by veins, located on the mesothorax or metathorax, functioning in flight\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the flat, paired appendage on the dorso-lateral region of the pterothorax." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: has_characteristic PATO:0000407 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! flat
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
property_value: IAO:0000589 "cuticle of insect wing" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000034
name: fore leg {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the prothorax that is anterior to the cuticle of a mid leg and composed of cuticle of procoxa, cuticle of protrochanter, cuticle of profemur, cuticle of protibia, cuticle of protarsus, and cuticle of propretarsus." [] {creation_date="2021-04-03", term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
relationship: anterior_to AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
relationship: has_part AISM:0000066 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! procoxa
relationship: has_part AISM:0000067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! protibia
relationship: has_part AISM:0000070 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! profemur
relationship: has_part AISM:0004171 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! protrochanter
relationship: has_part AISM:0004190 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! protarsus
relationship: has_part AISM:0004194 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! propretarsus
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax
property_value: IAO:0000589 "cuticle of fore leg" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000035
name: mid leg {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the mesothorax that is posterior to the cuticle of a fore leg, anterior to the cuticle of a hind leg, and composed of cuticle of mesocoxa, cuticle of mesotrochanter, cuticle of mesofemur, cuticle of mesotibia, cuticle of mesotarsus, and cuticle of mesopretarsus." [] {creation_date="2021-04-03", term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
relationship: anterior_to AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
relationship: has_part AISM:0000064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesocoxa
relationship: has_part AISM:0000068 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesotibia
relationship: has_part AISM:0000071 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesofemur
relationship: has_part AISM:0004172 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesotrochanter
relationship: has_part AISM:0004189 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesotarsus
relationship: has_part AISM:0004195 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopretarsus
relationship: part_of AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax
relationship: posterior_to AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of mid leg" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000036
name: hind leg {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the metathorax that is posterior to the cuticle of a mid leg and composed of cuticle of metacoxa, cuticle of metatrochanter, cuticle of metafemur, cuticle of metatibia, cuticle of metatarsus, and cuticle of metapretarsus." [] {creation_date="2021-04-03", term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
relationship: has_part AISM:0000065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metacoxa
relationship: has_part AISM:0000069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metatibia
relationship: has_part AISM:0000072 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metafemur
relationship: has_part AISM:0004173 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metatrochanter
relationship: has_part AISM:0004188 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metatarsus
relationship: has_part AISM:0004196 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapretarsus
relationship: part_of AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax
relationship: posterior_to AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of hind leg" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000037
name: fore wing {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired insect wing that is continuous with the mesonotum." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000033 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect wing
relationship: continuous_with AISM:0000052 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesonotum
property_value: IAO:0000589 "cuticle of fore wing" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000038
name: hind wing {IAO:0000232="2021-12-08Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired insect wing that is continuous with the metanotum." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000033 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect wing
relationship: continuous_with AISM:0000169 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metanotum
property_value: IAO:0000589 "cuticle of hind wing" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000039
name: cuticular seta {creation_date="2020-11-11", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Seta (=macrotrichium): articulated hair with socket, formed by trichogen cell.\"", term:modified="2021-12-10"}
def: "The unicellular cuticular evagination that constitutes a sclerite with its base surrounded by socket membrane." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: AISM:0000127 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! unicellular cuticular evagination
relationship: AISM:0000079 AISM:0000102 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by ring conjunctiva

[Term]
id: AISM:0000040
name: cuticular spur {source="https://doi.org/10.1016/0020-7322(79)90013-8", AISM:0000171="Richards AG, Richards PA (1979) The cuticular protuberances of insects. International Journal of Insect Morphology and Embryology 8: 143–157. \n\n\"Multicellular protuberances without differentiation of specialized cells\"", term:modified="2021-12-10"}
def: "The multicellular evagination of the cuticle that corresponds to an epithelial fold, composed of some sclerite that is encricled by a conjunctiva (moveable)." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: AISM:0000128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! multicellular cuticular evagination
relationship: AISM:0000079 AISM:0000102 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by ring conjunctiva
property_value: curator_notes "The difference between an appendage and a spur is the lack of muscles attached to the spur, otherwise, the mandible would be also a spur. Spines are multicellular evaginations that are not encircled by conjunctivae. Moveable beetle horns are spurs while not moveable beetle horns are spines." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000041
name: cuticular scale {term:modified="2021-12-10"}
def: "The seta that is flat." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000039 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular seta
relationship: has_characteristic PATO:0002254 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! flattened

[Term]
id: AISM:0000042
name: labrum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Labrum: unpaired upper lip, connected with distal edge of clypeus.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mouthpart and appendage that is attached to the clypeus by the clypeo-labral conjunctiva and to the proximal margin of the epipharynx." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000165 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mouthpart
relationship: adjacent_to AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus
relationship: continuous_with AISM:0004018 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeo-labral conjunctiva
property_value: IAO:0000589 "cuticle of labrum" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000043
name: insect mandible {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"The mandibles are the paired appendages of the 4th head segment and receive their innervation from the anterior part of the suboesophageal ganglion [...] They are primarily a compact, undivided and strongly sclerotized element without appendages.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mouthpart and sclerite between the cuticle of the labrum and the cuticle of the insect maxilla that is attached to the head capsule by the oral foraminal conjunctiva and the cranio-mandibular muscle." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: AISM:0000165 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mouthpart
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: anterior_to AISM:0000044 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect maxilla
relationship: continuous_with AISM:0000082 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cranio-mandibular muscle
relationship: continuous_with AISM:0000099 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! oral foraminal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: posterior_to AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labrum
property_value: IAO:0000589 "cuticle of insect mandible" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000044
name: insect maxilla {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Maxilla: head appendage of segment 5, innervated by maxillary nerve originating from intermediate part of suboesophageal complex; primarily composed of cardo, stipes, endite lobes (lacinia, galea) and maxillary palp.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mouthpart appendage of the head capsule, between the cuticle of the insect mandible and the cuticle of the labium, composed of cuticle of cardo, which is attached to the cuticle of stipes by the cardo-stipital conjunctiva; the cuticle of stipes, which is attached to the cuticle of galea by the stipito-galeal conjunctiva, to the cuticle of lacinia by the stipito-lacinial conjunctiva, and to the cuticle of palpifer by the stipito-palpiferal conjunctiva; the cuticle of palpifer is attached to the cuticle of maxillary palpus by the palpifero-palpal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000165 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mouthpart
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: anterior_to AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: has_part AISM:0000018 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cardo
relationship: has_part AISM:0000023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! galea
relationship: has_part AISM:0000026 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! lacinia
relationship: has_part AISM:0000051 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpus
relationship: has_part AISM:0000110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cardo-stipital conjunctiva
relationship: has_part AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: has_part AISM:0004001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifer
relationship: has_part AISM:0004009 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-lacinial conjunctiva
relationship: has_part AISM:0004010 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-palpiferal conjunctiva
relationship: has_part AISM:0004011 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-galeal conjunctiva
relationship: has_part AISM:0004012 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifero-palpal conjunctiva
relationship: posterior_to AISM:0000043 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mandible
property_value: IAO:0000589 "cuticle of insect maxilla" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000045
name: mesothoracic-metathoracic conjunctiva
def: "The conjunctiva of the insect thorax that connects the mesothorax and the metathorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0004126 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesothorax
relationship: continuous_with AISM:0004127 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metathorax
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0000046
name: prothoracic-mesothoracic conjunctiva
def: "The conjunctiva of the insect thorax joining the prothorax and the mesothorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2020-03-18"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax
relationship: continuous_with AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0000047
name: pretarsus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pretarsus: apical element of leg bearing ungues; distinct and cylindrical in entognathous hexapods, strongly reduced in Insecta.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the insect leg that is attached to the cuticle of tarsus by the tarso-pretarsal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect appendage
relationship: continuous_with AISM:0004187 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarso-pretarsal conjunctiva
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of pretarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000048
name: ligula {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"Ligula - The terminal lobes of the labium collectively, or a terminal part of the labium formed by the union of the lobes.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the cuticle of labium composed of the cuticle of glossa and cuticle of paraglossa jointly." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: has_part AISM:0000049 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! glossa
relationship: has_part AISM:0000050 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraglossa
relationship: part_of AISM:0000087 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! labium
property_value: IAO:0000589 "cuticle of ligula" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000049
name: glossa {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Glossa: paired inner endite lobes of the prementum.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the labium, and part of the ligula, that is attached to the prementum by the premental-glossal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: adjacent_to AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: continuous_with AISM:0004016 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-glossal conjunctiva
relationship: part_of AISM:0000048 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ligula
property_value: IAO:0000589 "cuticle of glossa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000050
name: paraglossa {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Paraglossa: paired outer endite lobes of the prementum (labium).\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired appendage of the labium, and part of the ligula, that is attached to the cuticle of prementum by the premental-paraglossal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: adjacent_to AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: continuous_with AISM:0004015 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-paraglossal conjunctiva
relationship: part_of AISM:0000048 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ligula
property_value: IAO:0000589 "cuticle of paraglossa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000051
name: maxillary palpus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Palp: tactile appendage of maxilla\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the insect maxilla that is attached to the cuticle of palpifer by the palpifero-palpal conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: adjacent_to AISM:0004001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifer
relationship: AISM:0000079 AISM:0004012 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by palpifero-palpal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: has_part AISM:0002036 {creation_date="2023-04-13"} ! maxillary palpomere
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla
property_value: IAO:0000589 "cuticle of maxillary palpus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000052
name: mesonotum
def: "The notum or sclerite on the dorsal region of the mesothorax that is posterior to the pronotum, connected via the mesonoto-mesopleural conjuntiva to the dorsal margin of the mesopleuron, that is not adjacent to the mesocoxa, but attached to it by the mesocoxal muscle." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="jcgiron"} ! insect sclerite
is_a: AISM:0004128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! notum
is_a: UBERON:0000061 ! anatomical structure
relationship: attaches_to AISM:0000085 {x_1.1:contributor="jcgiron"} ! mesocoxal muscle
relationship: continuous_with AISM:0004219 {x_1.1:contributor="jcgiron"} ! mesonoto-mesopleural conjuntiva
relationship: posterior_to AISM:0000059 {x_1.1:contributor="jcgiron"} ! pronotum

[Term]
id: AISM:0000053
name: mesopectus {creation_date="2020-11-11"}
def: "The sclerite that is continuous with the basal mesocoxal conjunctiva and the basal wing conjunctiva and contains the mesofurca." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: continuous_with AISM:0000103 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal mesocoxal conjunctiva
relationship: continuous_with AISM:0004203 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal wing conjunctiva
relationship: has_part AISM:0000141 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesofurca

[Term]
id: AISM:0000054
name: mesotrochantin {creation_date="2020-11-11"}
def: "The trochantin that is located on the ventro-lateral region of the mesothorax and is attached to a mesocoxa and surrounded by the basal mesocoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004135 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! trochantin
relationship: adjacent_to AISM:0000064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesocoxa
relationship: AISM:0000079 AISM:0000103 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by basal mesocoxal conjunctiva

[Term]
id: AISM:0000055
name: protrochantin {creation_date="2020-11-11"}
def: "The trochantin that is located on the ventro-lateral region of the prothorax and is attached to a procoxa and surrounded by the basal procoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004135 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! trochantin
relationship: adjacent_to AISM:0000066 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! procoxa
relationship: AISM:0000079 AISM:0000106 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by basal procoxal conjunctiva

[Term]
id: AISM:0000056
name: metatrochantin {creation_date="2020-11-11"}
def: "The trochantin that is located on the ventro-lateral region of the metathorax and is attached to a metacoxa and surrounded by the basal metacoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004135 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! trochantin
relationship: adjacent_to AISM:0000065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metacoxa
relationship: AISM:0000079 AISM:0000104 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by basal metacoxal conjunctiva

[Term]
id: AISM:0000057
name: prementum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prementum: distal main element of labium, bearing the endite lobes (glossa and paraglossa) and the labial palp.\""}
def: "The sclerite of the labium that is connected to the mentum by the mental-premental conjunctiva, to the palpiger by the premental-palpigeral conjunctiva, to the paraglossa by the premental-paraglossal conjunctiva, and to the glossa by the premental-glossal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: adjacent_to AISM:0000049 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! glossa
relationship: adjacent_to AISM:0000050 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraglossa
relationship: adjacent_to AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum
relationship: adjacent_to AISM:0004006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpiger
relationship: continuous_with AISM:0004002 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mental-premental conjunctiva
relationship: continuous_with AISM:0004014 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-palpigeral conjunctiva
relationship: continuous_with AISM:0004015 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-paraglossal conjunctiva
relationship: continuous_with AISM:0004016 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-glossal conjunctiva
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0000058
name: prepectus {creation_date="2020-11-11"}
def: "The sclerite that is posterior to the pronotum and receives the site of attachment of the dilutor muscle of the first thoracic spiracle." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: UBERON:0000061 ! anatomical structure

[Term]
id: AISM:0000059
name: pronotum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pronotum: prothoracic tergum.\""}
def: "The notum or sclerite on the dorsal region of the prothorax that is attached to cranial muscles, procoxal muscles, contiuous posterioirly with the neck membrane and with pronoto-propleural conjunctiva and not adjacent (not touching) to the procoxa." [] {term:modified="2022-03-09", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-03-18"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: AISM:0004128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! notum
is_a: UBERON:0000061 ! anatomical structure
relationship: anteriorly_connected_to AISM:0000098 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! neck membrane
relationship: attaches_to AISM:0000080 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect cranial muscle
relationship: attaches_to AISM:0000145 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! procoxal muscle
relationship: continuous_with AISM:0004220 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! pronoto-propleural conjunctiva

[Term]
id: AISM:0000060
name: labial palpomere {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mere that is part of the labial palpus." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000073 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mere
relationship: part_of AISM:0000024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labial palpus
property_value: IAO:0000589 "cuticle of labial palpomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000061
name: prosternum
def: "The sclerite on the ventral region of the prothorax that bears the profurca and is attached to the propleuro-prosternal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004130 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! sternum
relationship: continuous_with AISM:0004202 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! propleuro-prosternal conjunctiva
relationship: has_part AISM:0000143 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! profurca

[Term]
id: AISM:0000062
name: ring sclerite
def: "The sclerite that is cylindrical and encircles and is encircled by conjunctiva." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: AISM:0000078 AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles conjunctiva
relationship: AISM:0000079 AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by conjunctiva
relationship: has_characteristic PATO:0001873 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cylindrical

[Term]
id: AISM:0000063
name: appendage segment {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The ring sclerite that is part of an appendage and is attached to muscle." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000062 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ring sclerite
relationship: continuous_with UBERON:0014895 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! somatic muscle
relationship: part_of AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
property_value: IAO:0000589 "cuticle of appendage segment" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000064
name: mesocoxa {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the mid leg that is attached to the latero-ventral region of the mesothorax by the basal mesocoxal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000077 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxa
relationship: AISM:0000079 AISM:0000103 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by basal mesocoxal conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of mesocoxa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000065
name: metacoxa {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the hind leg that is attached to the latero-ventral region of the metathorax by the basal metacoxal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000077 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxa
relationship: AISM:0000079 AISM:0000104 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by basal metacoxal conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metacoxa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000066
name: procoxa {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the fore leg that is attached to the latero-ventral region of the prothorax by the basal procoxal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000077 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxa
relationship: AISM:0000079 AISM:0000106 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by basal procoxal conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of procoxa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000067
name: protibia {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a fore leg attached to the distal margin of the profemur by the profemoro-protibial conjunctiva." [] {creation_date="2021-04-03", term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibia
relationship: AISM:0000079 AISM:0004179 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by profemoro-protibial conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of protibia" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000068
name: mesotibia {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a mid leg attached to the distal margin of the mesofemur by the mesofemoro-mesotibial conjunctiva." [] {creation_date="2021-04-03", term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibia
relationship: AISM:0000079 AISM:0004180 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesofemoro-mesotibial conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of mesotibia" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000069
name: metatibia {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a hind leg attached to the distal margin of the metafemur by the metafemoro-metatibial conjunctiva." [] {creation_date="2021-04-03", term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibia
relationship: AISM:0000079 AISM:0004181 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metafemoro-metatibial conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metatibia" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000070
name: profemur {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a fore leg attached to the distal margin of the protrochanter by the protrochantero-profemoral conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femur
relationship: AISM:0000079 AISM:0000123 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by procoxal-protrochanteral conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of profemur" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000071
name: mesofemur {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a mid leg attached to the distal margin of the mesotrochanter by the mesotrochantero-mesofemoral conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femur
relationship: AISM:0000079 AISM:0000124 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesocoxal-mesotrochanteral conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of mesofemur" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000072
name: metafemur {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a hind leg attached to the distal margin of the metatrochanter by the metatrochantero-metafemoral conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femur
relationship: AISM:0000079 AISM:0000125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metacoxal-metatrochanteral conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metafemur" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000073
name: mere {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The ring sclerite that is part of an appendage and is not attached to somatic muscle." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000062 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ring sclerite
relationship: part_of AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
property_value: IAO:0000589 "cuticle of mere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000074
name: tarsomere {AISM:0000171="\"Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tarsomere: subelement of tarsus in Insecta; number often taxon-specific, sometimes differing on legs of different segments (diagnostic value: tarsal formula).\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mere that is part of the tarsus." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000073 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mere
relationship: part_of AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsus
property_value: IAO:0000589 "cuticle of tarsomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000075
name: tibia {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tibia: 4th element of leg; usually cylindrical and equipped with paired terminal spurs, often with rows of spines.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a leg attached to the distal margin of the femur by the femoro-tibial conjunctiva." [] {creation_date="2021-04-03", term:modified="2021-12-08", comment="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! appendage segment
relationship: AISM:0000079 AISM:0004178 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by femoro-tibial conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of tibia" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000076
name: femur {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Femur: 3rd element of leg, often largest part.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a leg attached to the distal margin of the trochanter by the trochantero-femoral conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! appendage segment
relationship: AISM:0000079 AISM:0004174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by trochantero-femoral conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of femur" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000077
name: coxa {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxa: basal element of leg; articulated with pleural, sternal and usually also trochantinal elements of thoracic segment.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the leg that is attached to the latero-ventral region of the insect thorax by the basal coxal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000063 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! appendage segment
relationship: AISM:0000079 AISM:0000173 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by basal coxal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of coxa" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000080
name: insect cranial muscle
def: "The somatic muscle that is attached to the head capsule." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: UBERON:0014895 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"} ! somatic muscle
relationship: attaches_to AISM:0000019 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! head capsule

[Term]
id: AISM:0000081
name: cranio-antennal muscle
def: "The somatic muscle that is attached to the head capsule and the antenna." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: AISM:0000080 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranial muscle
relationship: attaches_to AISM:0000032 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! antenna

[Term]
id: AISM:0000082
name: cranio-mandibular muscle
def: "The somatic muscle that is attached to the head capsule and the insect mandible." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: AISM:0000080 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect cranial muscle
relationship: attaches_to AISM:0000043 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect mandible

[Term]
id: AISM:0000083
name: cranio-labial muscle
def: "The somatic muscle that is attached to the head capsule and the labium." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000080 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranial muscle
relationship: attaches_to AISM:0000087 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! labium

[Term]
id: AISM:0000084
name: cranio-labral muscle
def: "The somatic muscle that is attached to the head capsule and the labrum." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: AISM:0000080 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranial muscle
relationship: attaches_to AISM:0000042 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! labrum

[Term]
id: AISM:0000085
name: mesocoxal muscle {creation_date="2020-11-11"}
def: "The coxal muscle of the mesocoxa." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000086 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxal muscle
relationship: attaches_to AISM:0000064 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesocoxa

[Term]
id: AISM:0000086
name: coxal muscle
def: "The somatic muscle that inserts in the coxa." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21", term:modified="2021-12-13"}
is_a: AISM:0002064 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect leg muscle
relationship: attaches_to AISM:0000077 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxa
property_value: curator_notes "All of the coxal muscles, except the second sternal-metacoxal muscle, are attached to the thorax." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}

[Term]
id: AISM:0000087
name: labium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"The labium or lower lip forms the posterior (orthognathous head) or ventral (prognathous head) closure of the preoral space and of the salivarium. It is homologous to the maxilla (2nd maxilla) of crustaceans, but its proximal\nparts form a structural unit without a recognizable median line or suture.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mouthpart appendage composed of the cuticle of submentum, which is attached by the submental-mental conjunctiva to the cuticle of mentum, which is attached by the mental-premental conjunctiva to the cuticle of prementum, which is attached to the cuticle of palpiger by the premental-palpigeral conjunctiva, the cuticle of paraglossa by the premental-paraglossal conjunctiva, and the cuticle of glossa by the premental-glossal conjunctiva; the cuticle of palpiger is attached by the palpigero-palpal conjunctiva to the cuticle of labial palpus." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000165 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mouthpart
relationship: has_part AISM:0000024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labial palpus
relationship: has_part AISM:0000048 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ligula
relationship: has_part AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: has_part AISM:0004002 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mental-premental conjunctiva
relationship: has_part AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum
relationship: has_part AISM:0004005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submentum
relationship: has_part AISM:0004006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpiger
relationship: has_part AISM:0004013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submental-mental conjunctiva
relationship: has_part AISM:0004014 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-palpigeral conjunctiva
relationship: has_part AISM:0004015 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-paraglossal conjunctiva
relationship: has_part AISM:0004016 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-glossal conjunctiva
relationship: has_part AISM:0004017 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpigero-palpal conjunctiva
property_value: IAO:0000589 "cuticle of labium" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000088
name: eye cuticle {creation_date="2020-11-11"}
def: "The elastic cuticle of the head capsule that is transparent and covers the eye." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000007 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elastic cuticle
relationship: has_characteristic PATO:0000964 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! transparent
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0000089
name: insect ligament {creation_date="2020-11-11", IAO:0000232="Modified 2023-01-09 to specify insect ligament.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The resilin rich region that connects two sclerites." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000007 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elastic cuticle
relationship: continuous_with AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: part_of AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva

[Term]
id: AISM:0000090
name: cuticular tendon {AISM:0000171="Klass K-D (2001) The female abdomen of the viviparous earwig Hemimerus vosseleri (Insecta: Dermaptera: Hemimeridae), with a discussion of the postgenital abdomen of Insecta. Zoological Journal of the Linnean Society 131: 251–307. \n\nhttps://doi.org/10.1111/j.1096-3642.2001.tb02239.x \n\n\"tendon is used herein to designate membranous internal cuticular projections\""}
def: "The apodeme of elastic cuticle that is continuous with somatic muscle." [] {x_1.1:contributor="2022-06-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000007 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elastic cuticle
is_a: AISM:0000188 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! apodeme
relationship: continuous_with UBERON:0014895 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! somatic muscle
property_value: curator_notes "The usually cylindircal evagination of the cuticle that is resilin rich and is continuous with somatic muscles." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000091
name: insect trachea {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Trachea: tube-shaped elements of the tracheal system.\"", IAO:0000232="Modified 2023-01-09 to specify insect trachea.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The branching invagination of elastic cuticle that is cylindrical and contains taenidia." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000007 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elastic cuticle
is_a: AISM:0000136 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branching cuticular invagination
relationship: has_characteristic PATO:0001873 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cylindrical
relationship: has_part AISM:0000140 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! taenidium

[Term]
id: AISM:0000093
name: hypopharynx {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Hypopharynx: median unpaired lobe between mouthparts and epipharynx; anterior (dorsal) surface continuous with anterior pharynx.\""}
def: "The conjunctiva of the insect head that is attached to the salivarium and to the oral foraminal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000099 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! oral foraminal conjunctiva
relationship: continuous_with AISM:0000159 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! salivarium
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head

[Term]
id: AISM:0000094
name: mesopleuro-metapleural conjunctiva
def: "The conjunctiva of the insect thorax that joins the mesopleuron and the metapleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuron
relationship: continuous_with AISM:0004186 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopleuron
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0000095
name: metasterno-metacoxal conjunctiva
def: "The conjunctiva of the mesothorax that joins the metasternum and the metacoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metacoxa
relationship: continuous_with AISM:0004232 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metasternum
relationship: part_of AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax

[Term]
id: AISM:0000096
name: prosternal-procoxal conjunctiva
def: "The conjunctiva of the prothorax that joins the prosternum and the procoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prosternum
relationship: continuous_with AISM:0000066 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! procoxa
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0000097
name: metapleuro-metacoxal conjunctiva
def: "The conjunctiva of the metathorax that joins the metapleuron and the metacoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metacoxa
relationship: continuous_with AISM:0000119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuron
relationship: part_of AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax

[Term]
id: AISM:0000098
name: neck membrane
def: "The conjuctiva that is continuous with the posterior margin of the head capsule and with the anterior margin of the prothorax, and bears cervical sclerites." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", term:modified="2022-06-27"}
synonym: "cervical membrane" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Cervical membrane: membrane connecting the head and prothorax.\""}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: AISM:0000078 AISM:0004141 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles cervical sclerite

[Term]
id: AISM:0000099
name: oral foraminal conjunctiva
def: "The conjunctiva of the insect head that connects the head capsule and the mouthparts." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: adjacent_to AISM:0000165 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mouthpart
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head

[Term]
id: AISM:0000100
name: pronoto-mesonotal conjunctiva
def: "The conjunctiva of the insect thorax that joins the pronotum and the mesonotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: continuous_with AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0000101
name: pronoto-mesopectal conjunctiva
def: "The conjunctiva that is attached to the pronotum and the mesopectus." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000053 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopectus
relationship: continuous_with AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum

[Term]
id: AISM:0000102
name: ring conjunctiva
def: "The conjunctiva that encircles a ring sclerite." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: AISM:0000078 AISM:0000062 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles ring sclerite

[Term]
id: AISM:0000103
name: basal mesocoxal conjunctiva
def: "The conjunctiva that encircles the mesocoxa and connects it to the ventral and lateral regions of the mesothorax." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000173 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal coxal conjunctiva
relationship: continuous_with AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax

[Term]
id: AISM:0000104
name: basal metacoxal conjunctiva
def: "The conjunctiva that encircles the metacoxa and connects it to the ventral and lateral regions of the metathorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000173 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! basal coxal conjunctiva
relationship: continuous_with AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax

[Term]
id: AISM:0000105
name: epipharynx {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Epipharynx: semimembranous or membranous posterior wall of labrum and roof of cibarium.\""}
def: "The conjunctiva of the insect head that is connected to the oral foraminal conjunctiva and to the distal margin of the labrum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000099 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! oral foraminal conjunctiva
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head

[Term]
id: AISM:0000106
name: basal procoxal conjunctiva
def: "The conjunctiva that encircles the procoxa and connects it to the ventral and lateral regions of the prothorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000173 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! basal coxal conjunctiva
relationship: continuous_with AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0000107
name: insect head {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"The head is a compact and complex tagma with a concentration of a broad array of structures und functions. It is equipped with sense organs such as the highly complex compound eyes and the antennae, an elaborate set of mouthparts, and a complex muscle apparatus. It also contains central elements of the nervous system, the anterior part of the digestive tract including the cibarium (preoral cavity) and the salivarium, and also neurohaemal organs.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticular region that is anterior (distal) to the neck membrane (encircled by the neck membrane) and contains the head capsule, the antenna, the eyes, mouthparts and surrounds the brain." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:6007289 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect tagmatic subdivision of integument
intersection_of: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect region of cuticle
intersection_of: UBERON:6007289 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect tagmatic subdivision of integument
intersection_of: anterior_to AISM:0000098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! neck membrane
intersection_of: has_part AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! head capsule
relationship: AISM:0000079 AISM:0000098 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by neck membrane
relationship: anterior_to AISM:0000098 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! neck membrane
relationship: has_part AISM:0000019 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! head capsule
relationship: has_part AISM:0000032 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! antenna
relationship: has_part AISM:0000093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hypopharynx
relationship: has_part AISM:0000099 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! oral foraminal conjunctiva
relationship: has_part AISM:0000105 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epipharynx
relationship: has_part AISM:0000112 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cranio-antennal conjunctiva
relationship: has_part AISM:0000165 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mouthpart
relationship: surrounds UBERON:0000955 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! brain
property_value: IAO:0000589 "cuticle of insect head" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000108
name: insect thorax {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of cuticle that is connected to some muscles of the fore and hind legs and is posterior to the neck membrane and aterior to the first abdominal spiracle." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
is_a: UBERON:6007289 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect tagmatic subdivision of integument
intersection_of: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect region of cuticle
intersection_of: UBERON:6007289 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect tagmatic subdivision of integument
intersection_of: anterior_to AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect abdomen
intersection_of: posterior_to AISM:0000098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! neck membrane
relationship: anterior_to AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen
relationship: has_part AISM:0000085 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesocoxal muscle
relationship: has_part AISM:0000145 ! procoxal muscle
relationship: has_part AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax
relationship: has_part AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax
relationship: has_part AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax
relationship: posterior_to AISM:0000098 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! neck membrane
property_value: curator_notes "The hind leg muscles sometimes attach to the second abdominal sternite. The abdominal sopiracles are different in their structure from tghe thoracic spiracles as they are opened and closed by two articulating sclerites that are moved by two sets of muscles whereas the thoracic spiracles are closed by only one occlusor muscle and opened by the flexibility of the distal tracheal region. The border between the thorax and the abdomen is sometimes marked by the anterior first abdmonial tergal conjunctiva. In Hymenoptera, the border between the abdomen and the thorax cannot be defined as the anterior first abdmonial tergal conjunctiva is absent, the sclerite that receives muscles from the metacoxa also contains the first abdominal spiracle." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}
property_value: IAO:0000589 "cuticle of insect thorax" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000109
name: insect abdomen {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle that is an insect tagmatic subdivision of the integument, posterior to the thorax." [] {creation_date="2020-11-11", IAO:0000232="Modified 2024-01-25: added 'insect tagmatic subdivision of integument'.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
is_a: UBERON:6007289 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect tagmatic subdivision of integument
intersection_of: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect region of cuticle
intersection_of: UBERON:6007289 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect tagmatic subdivision of integument
intersection_of: posterior_to AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect thorax
relationship: depiction https://ndownloader.figshare.com/files/6014256/preview/6014256/preview.jpg
relationship: has_part AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen
relationship: has_part AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
relationship: posterior_to AISM:0000108 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thorax
property_value: curator_notes "The thorax is defined based on local properties (e.g. attachment sites of coxal muscles) and therefore we can reference this class for the definition of the abdomen." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}
property_value: IAO:0000589 "cuticle of insect abdomen" xsd:string {comment="2023-04-13"}

[Term]
id: AISM:0000110
name: cardo-stipital conjunctiva
def: "The conjunctiva of the insect maxilla that connects the cardo and the stipes." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000018 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cardo
relationship: continuous_with AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla

[Term]
id: AISM:0000111
name: stipes {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Stipes: second element of maxilla, connected with cardo by a hinge; bearing endite lobes (galea and lacinia) and maxillary palp.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the sclerite of the insect maxilla that is attached to the cuticle of cardo by the cardo-stipital conjunctiva, attached to the cuticle of lacinia by the stipito-lacinial conjunctiva, attached to the cuticle of palpifer by the stipito-palpiferal conjunctiva, and attached to the cuticle of galea by the stipito-galeal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: adjacent_to AISM:0000018 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cardo
relationship: adjacent_to AISM:0000023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! galea
relationship: adjacent_to AISM:0000026 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! lacinia
relationship: adjacent_to AISM:0004001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifer
relationship: continuous_with AISM:0000110 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cardo-stipital conjunctiva
relationship: continuous_with AISM:0004009 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-lacinial conjunctiva
relationship: continuous_with AISM:0004010 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-palpiferal conjunctiva
relationship: continuous_with AISM:0004011 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-galeal conjunctiva
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla
property_value: IAO:0000589 "cuticle of stipes" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000112
name: cranio-antennal conjunctiva
def: "The conjunctiva that encircles the base of the antenna (scape) and is encircled by the head capsule as the antennal foramen." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: AISM:0000078 AISM:0000113 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles scapus
relationship: AISM:0000079 AISM:0000019 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by head capsule
relationship: continuous_with AISM:0000019 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! head capsule

[Term]
id: AISM:0000113
name: scapus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\nScapus: basal element of antenna, with two muscles attached to the pedicellus.", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the antenna that is connected to the head capsule and the antennifer by the basal antennal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
synonym: "antennomere 1" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000063 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! appendage segment
is_a: AISM:0004266 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antennomere
relationship: adjacent_to AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: adjacent_to AISM:0000190 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antennifer
relationship: continuous_with AISM:0000112 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cranio-antennal conjunctiva
property_value: IAO:0000589 "cuticle of scapus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000114
name: scapal-pedicellar conjunctiva
def: "The conjunctiva of the antenna that connects the scapus and the pedicellus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000102 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000115 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles pedicellus
relationship: AISM:0000079 AISM:0000113 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by scapus
relationship: part_of AISM:0000032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antenna

[Term]
id: AISM:0000115
name: pedicellus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pedicellus: second antennal segment in Insecta; contains Johnston’s organ and lacks intrinsic muscles.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the antenna that is attached to the scapus by the scapal-pedicellar conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
synonym: "antennomere 2" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000063 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! appendage segment
is_a: AISM:0004266 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antennomere
relationship: AISM:0000079 AISM:0000114 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by scapal-pedicellar conjunctiva
property_value: IAO:0000589 "cuticle of pedicellus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000116
name: flagellomere {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mere that is part of the antenna." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004266 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antennomere
relationship: distal_to AISM:0000115 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! pedicellus
property_value: curator_notes "Given the high number of flagellomeres occurring in some taxa, Arabic numerals are used instead of Roman numerals for practicality reasons." xsd:string {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
property_value: IAO:0000589 "cuticle of flagellomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000117
name: flagellomere 1 {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Flagellomere: segment of the flagellum.\"", IAO:0000232="Modified 2023-05-05: \"first\" replaced with \"1\"\ngmontanaro https://orcid.org/0000-0003-0836-1364", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the first flagellomere of the antenna, attached to the pedicel by the pedicel-first flagellomere conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
synonym: "antennomere 3" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! flagellomere
relationship: AISM:0000079 AISM:0000118 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by pedicellar-first flagellomeral conjunctiva
property_value: IAO:0000589 "cuticle of first flagellomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000118
name: pedicellar-first flagellomeral conjunctiva
def: "The conjunctiva of the antenna that connects the pedicellus and the first flagellomere." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: AISM:0000078 AISM:0000117 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles flagellomere 1
relationship: AISM:0000079 AISM:0000115 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by pedicellus
relationship: part_of AISM:0000032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antenna

[Term]
id: AISM:0000119
name: metapleuron
def: "The region of the cuticle on the lateral region of the metathorax that is attached to the metanotum and the metasternum, and is attached to the metacoxa by the metacoxal muscle and the basal metacoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004129 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! pleuron
relationship: adjacent_to AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum
relationship: adjacent_to AISM:0004232 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metasternum
relationship: continuous_with AISM:0000104 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal metacoxal conjunctiva
relationship: continuous_with AISM:0000146 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metacoxal muscle

[Term]
id: AISM:0000120
name: propleuro-procoxal conjunctiva
def: "The conjunctiva of the prothorax that joins the propleuron and the procoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000066 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! procoxa
relationship: continuous_with AISM:0004142 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! propleuron
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0000121
name: mesosternum
def: "The sclerite on the ventral region of the mesothorax that bears the mesofurca and is attached to the mesopleuro-mesosternal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum
relationship: continuous_with AISM:0004231 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopleuro-mesosternal conjunctiva
relationship: has_part AISM:0000141 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesofurca

[Term]
id: AISM:0000123
name: procoxal-protrochanteral conjunctiva
def: "The conjunctiva of the fore leg joining the distal margin of a procoxa and the proximal margin of a protrochanter." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004170 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxal-trochanteral conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg

[Term]
id: AISM:0000124
name: mesocoxal-mesotrochanteral conjunctiva
def: "The conjunctiva of the mid leg joining the distal margin of a mesocoxa and the proximal margin of a mesotrochanter." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004170 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxal-trochanteral conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg

[Term]
id: AISM:0000125
name: metacoxal-metatrochanteral conjunctiva
def: "The conjunctiva of the hind leg joining the distal margin of a metacoxa and the proximal margin of a metatrochanter." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004170 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxal-trochanteral conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg

[Term]
id: AISM:0000126
name: socket membrane {creation_date="2020-11-11"}
def: "The conjunctiva that corresponds to one epithelial cell and surrounds a sclerotized unicellular cuticular evagination." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: RO:0002008 CL:0000066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epithelial cell
property_value: curator_notes "Should coincide with 'exactly one' epithelial cell, but that violates OWL specs." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-26"}

[Term]
id: AISM:0000127
name: unicellular cuticular evagination
def: "The cuticular evagination that corresponds to the evagination on the membrane of a single cell and not to the evagination of a cell layer." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000027 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular evagination
relationship: RO:0002008 CL:0000066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epithelial cell
property_value: curator_notes "Should coincide with 'exactly one' epithelial cell, but that violates OWL specs." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-26"}

[Term]
id: AISM:0000128
name: multicellular cuticular evagination {creation_date="2020-11-11"}
def: "The region of cuticle that corresponds to the evagination of the single layer epithelium." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000027 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular evagination

[Term]
id: AISM:0000130
name: uniporous sensillum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The seta that has one opening distally." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_part AISM:0000039 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular seta
relationship: has_part AISM:0000177 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! pore canal
property_value: curator_notes "Should coincide with 'exactly one' pore canal, but that violates OWL specs." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-23"}

[Term]
id: AISM:0000131
name: multiporous sensillum {creation_date="2020-11-11", IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Ando, T., Sekine, S., Inagaki, S., Misaki, K., Badel, L., Moriya, H., Sami, M.M., Itakura, Y., Chihara, T., Kazama, H. and Yonemura, S., 2019. Nanopore formation in the cuticle of an insect olfactory sensillum. Current Biology, 29(9), pp.1512-1520.\nhttps://www.sciencedirect.com/science/article/pii/S0960982219303410#fig4"}
def: "The seta that has multiple cuticular pores (openings of class III exocrine glands)." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_characteristic PATO:0000984 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! porous
relationship: has_part AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular seta

[Term]
id: AISM:0000132
name: placoid sensillum {creation_date="2020-11-11"}
def: "The multiporous plate that is elongated." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000133 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! multiporous plate
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elongated

[Term]
id: AISM:0000133
name: multiporous plate {creation_date="2020-11-11"}
def: "The multiporous sensillum that is flat." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000131 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! multiporous sensillum
relationship: has_characteristic PATO:0000407 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! flat

[Term]
id: AISM:0000134
name: cuticular exocrine gland duct {creation_date="2020-11-11", term:modified="2021-12-10"}
def: "The branching cuticular invagination that corresponds to the invagination of the membrane of a single cell and does not contain taenidia." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000136 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branching cuticular invagination
relationship: RO:0002008 CL:0000066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epithelial cell
property_value: curator_notes "Should coincide with 'exactly one' epithelial cell, but that violates OWL specs." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-26"}

[Term]
id: AISM:0000135
name: insect spiracle {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Spiracle: external opening of the tracheal system.\"", term:modified="2023-01-09", IAO:0000232="Modified 2023-01-09: specifying insect spiracle.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The region of the cuticle that is continuous to the proximal region of a trachea and can be closed by muscles." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
is_a: UBERON:0000061 ! anatomical structure
relationship: attaches_to UBERON:0014895 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! somatic muscle

[Term]
id: AISM:0000136
name: branching cuticular invagination
def: "The cuticular ivagination that ramifies into umerous branches." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000006 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular invagination
relationship: has_characteristic PATO:0000402 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branched
property_value: curator_notes "Branching cuticular invaginations porvide important models for branchig morphogenesis." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000137
name: malphigian tube {creation_date="2020-11-11"}
def: "The branching cuticular invagination that is located between the mid and hindgut." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
xref: http://purl.obolibrary.org/obo/UBERON_0001054
is_a: AISM:0000136 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branching cuticular invagination

[Term]
id: AISM:0000138
name: cuticular apophysis {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Apophysis: hollow cuticular invagination.\"", term:modified="2021-12-10"}
def: "The cuticular invagination that is hollow." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000006 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular invagination
is_a: AISM:0000188 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! apodeme
relationship: RO:0002008 AISM:0000193 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with cuticular pit
property_value: curator_notes "The apophysis in HAO refers to an ivagination of the cuticle that is cylindrical as opposed to a ridge that is elongate. Beutel et al. 2014 differentiate apodemes from apophyses in that apodemes are solid and apophyses are hollow." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000140
name: taenidium {creation_date="2020-11-11", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Taenidium: spiral-shaped strengthening ridge of the tracheae.\""}
def: "The coiled ridge in the wall of the trachea." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000158 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular ridge
relationship: has_characteristic PATO:0000404 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coiled

[Term]
id: AISM:0000141
name: mesofurca
def: "The furca of the mesothorax that is attached to the mesocoxa via muscle." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000144 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! furca
relationship: part_of AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax

[Term]
id: AISM:0000142
name: metafurca
def: "The furca of the metathorax that is attached to the metacoxa via muscle." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000144 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! furca
relationship: part_of AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax

[Term]
id: AISM:0000143
name: profurca
def: "The furca of the prothorax that is attached to the procoxa via muscle." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000144 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! furca
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0000144
name: furca {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Furca (=sternal apophysis, endosternite): endoskeletal element (entapophysis) of furcasternum; paired furcal arms often connected with pleural ridge by short muscle.\""}
def: "The apophysis that is located ventromedially on the thorax and is connected to the coxa via muscles." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
synonym: "endosternite" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Furca (=sternal apophysis, endosternite): endoskeletal element (entapophysis) of furcasternum; paired furcal arms often connected with pleural ridge by short muscle.\""}
is_a: AISM:0000136 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branching cuticular invagination
is_a: AISM:0000138 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular apophysis
is_a: UBERON:0000061 ! anatomical structure
relationship: part_of AISM:0000108 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thorax
relationship: part_of BSPO:0000112 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ventro-medial region

[Term]
id: AISM:0000145
name: procoxal muscle {creation_date="2020-11-11"}
def: "The coxal muscle of the procoxa." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000086 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxal muscle
relationship: attaches_to AISM:0000066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! procoxa

[Term]
id: AISM:0000146
name: metacoxal muscle {creation_date="2020-11-11"}
def: "The coxal muscle of the metacoxa." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000086 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coxal muscle
relationship: attaches_to AISM:0000065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metacoxa

[Term]
id: AISM:0000147
name: femoral muscle
def: "The somatic muscle that inserts in the femur." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0002064 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect leg muscle
relationship: attaches_to AISM:0000076 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! femur

[Term]
id: AISM:0000148
name: tibial muscle
def: "The somatic muscle that inserts in the tibia." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0002064 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect leg muscle
relationship: attaches_to AISM:0000075 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tibia

[Term]
id: AISM:0000149
name: pretarsal muscle
def: "The somatic muscle that inserts in the pretarsus." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", term:modified="2021-12-13"}
is_a: AISM:0002064 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect leg muscle
relationship: attaches_to AISM:0000047 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! pretarsus
property_value: curator_notes "There are usually two muscle bands of the pretarsal muscle, one is arising from the femur, the other from the tibia. The muscle usually inserts on a resilin rich basal sclerite of the pretarsus, the unguitractor plate." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000150
name: profemoral muscle
def: "The somatic muscle that inserts in the profemur." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000147 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! femoral muscle
relationship: attaches_to AISM:0000070 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! profemur

[Term]
id: AISM:0000151
name: mesofemoral muscle
def: "The somatic muscle that inserts in the mesofemur." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000147 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! femoral muscle
relationship: attaches_to AISM:0000071 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesofemur

[Term]
id: AISM:0000152
name: metafemoral muscle
def: "The somatic muscle that inserts in the metafemur." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000147 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! femoral muscle
relationship: attaches_to AISM:0000072 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metafemur

[Term]
id: AISM:0000153
name: protibial muscle
def: "The somatic muscle that inserts in the protibia." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000148 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tibial muscle
relationship: attaches_to AISM:0000067 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! protibia

[Term]
id: AISM:0000154
name: mesotibial muscle
def: "The somatic muscle that inserts in the mesotibia." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000148 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tibial muscle
relationship: attaches_to AISM:0000068 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesotibia

[Term]
id: AISM:0000155
name: metatibial muscle
def: "The somatic muscle that inserts in the metatibia." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0000148 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tibial muscle
relationship: attaches_to AISM:0000069 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metatibia

[Term]
id: AISM:0000156
name: cuticular fovea {term:modified="2021-12-10"}
def: "The cuticular depression that is circular." [] {creation_date="2020-11-11", IAO:0000232="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000005 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular depression
relationship: has_characteristic PATO:0000411 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! circular

[Term]
id: AISM:0000157
name: cuticular groove {term:modified="2021-12-10", IAO:0000232="former 'impression'\nimiko https://orcid.org/0000-0003-2938-9075"}
def: "The cuticular depression that is elongated and coincides with the distal side of an insect sclerite." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", IAO:0000232="Modified 2024-01-25: to reflect subclass of definiton\njgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000005 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular depression
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elongated
property_value: curator_notes "The cuticular depression (concavity on the surface of the cuticle) that does not correspond to a cuticular invagination (epithelial fold). The cuticule is less thick at the site of a cuticular impression." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-11"}

[Term]
id: AISM:0000158
name: cuticular ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ridge: cuticular strengthening ridge.\"\n\"They are not lines of fusion or molting lines.\"(p. 12)", term:modified="2021-12-10"}
def: "The invagination on a sclerite that is elongated." [] {creation_date="2020-11-11", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000000 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular internal depression
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elongated
relationship: part_of AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite

[Term]
id: AISM:0000159
name: salivarium {def="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Salivarium: posterior part of preoral space between hypopharynx and labium, with opening of salivary ducts.\""}
def: "The conjunctiva in the head capsule that forms a pouch between the hypopharynx and the labium and bears the exocrine gland duct." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
is_a: AISM:0000160 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular pouch
relationship: continuous_with AISM:0000087 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! labium
relationship: continuous_with AISM:0000093 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! hypopharynx
relationship: continuous_with AISM:0000134 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular exocrine gland duct
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0000160
name: cuticular pouch {term:modified="2021-12-10"}
def: "The invagination of the cuticle that is largely membranous." [] {creation_date="2020-11-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000006 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular invagination
relationship: has_part AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva

[Term]
id: AISM:0000161
name: discrimenal lamella
def: "The ridge that is in the sagittal line of the ventro-medial region of the thorax." [] {creation_date="2020-11-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000158 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular ridge
relationship: RO:0002008 BSPO:0000417 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with sagittal plane

[Term]
id: AISM:0000162
name: cuticular sulcus {term:modified="2021-12-10"}
def: "The cuticular depression (concavity on cuticle surface) that corresponds with a cuticular ridge (an elongate cuticular invagination)." [] {creation_date="2020-11-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", term:modified="2021-12-10"}
is_a: AISM:0000157 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular groove
relationship: RO:0002008 AISM:0000158 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with cuticular ridge

[Term]
id: AISM:0000163
name: discrimen {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Discrimen: longitudinal ridge medially dividing the sternum\""}
def: "The longitudinal (parallel to antero-posterior axis) sulcus that corresponds to the discrimenal lamella." [] {creation_date="2020-11-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000162 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sulcus
relationship: continuous_with AISM:0000161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! discrimenal lamella
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior-posterior axis

[Term]
id: AISM:0000165
name: mouthpart {creation_date="2020-11-17", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the insect head that is encircled by the oral foraminal conjunctiva." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21", term:modified="2021-12-10"}
is_a: AISM:0000029 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect appendage
relationship: AISM:0000079 AISM:0000099 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by oral foraminal conjunctiva
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head
property_value: IAO:0000589 "cuticle of mouthpart" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000166
name: propleuro-procoxal articulation
def: "The insect articulation between the propleuron and the procoxa." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect articulation

[Term]
id: AISM:0000167
name: articular surface
def: "The region of cuticle where two sclerites meet." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of cuticle
relationship: adjacent_to AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite

[Term]
id: AISM:0000168
name: salivary sclerite
def: "The sclerite of the salivarium." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: part_of AISM:0000159 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! salivarium

[Term]
id: AISM:0000169
name: metanotum
def: "The notum or sclerite on the dorsal region of the metathorax that is posterior to the mesonotum, connected via the metanoto-metapleural conjuntiva to the dorsal margin of the metapleuron, that is not adjacent to the metacoxa, but attached to it by the metacoxal muscle." [] {x_1.1:contributor="jcgiron", creation_date="2021-04-21"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
is_a: AISM:0004128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! notum
is_a: UBERON:0000061 ! anatomical structure
relationship: attaches_to AISM:0000146 {x_1.1:contributor="jcgiron"} ! metacoxal muscle
relationship: continuous_with AISM:0004221 {x_1.1:contributor="jcgiron"} ! metanoto-metapleural conjunctiva
relationship: posterior_to AISM:0000052 {x_1.1:contributor="jcgiron"} ! mesonotum

[Term]
id: AISM:0000170
name: metapectus
def: "The sclerite that is continuous with the basal metacoxal conjunctiva and the basal wing conjunctiva and contains the metafurca." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-04-21"}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: continuous_with AISM:0000104 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal metacoxal conjunctiva
relationship: continuous_with AISM:0004203 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal wing conjunctiva
relationship: has_part AISM:0000142 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metafurca

[Term]
id: AISM:0000172
name: intertarsomeral conjunctiva
def: "The conjunctiva is encircled by a tarsomere that encircles another tarsomere." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000074 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles tarsomere
relationship: AISM:0000079 AISM:0000074 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by tarsomere
relationship: continuous_with AISM:0000074 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsomere

[Term]
id: AISM:0000173
name: basal coxal conjunctiva
def: "The conjunctiva that encircles the coxa and connects it to the ventral and lateral thoracic regions." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-17"}
is_a: AISM:0000102 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ring conjunctiva
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax
property_value: curator_notes "These conjunctivae can be used as stable reference points in insects that poseess legs, and can be used to define sclerites on the lateral side of the thorax." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-17"}

[Term]
id: AISM:0000174
name: insect region of cuticle {IAO:0000232="Modified 2023-04-13: added insect to specify.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect region of integument that is part of the chitin-based cuticle." [] {creation_date="2020-11-23", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: BFO:0000004 ! independent continuant
relationship: part_of UBERON:0001001 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! chitin-based cuticle
relationship: part_of UBERON:6007284 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect region of integument
property_value: curator_notes "The AISM focuses on anatomical structures that are part of the insect (chitinous) cuticle. These structures are acellular regions of the integument. Regions of the insect cuticle with different mechanical properties (i.e. increased and descresed flexinility, thickness, and elasticity) are continuous with each other (e.g. sclerites are continuous with conjunctivae or resilin rich regions are continuous with regions with less resilin content)." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2020-11-23"}

[Term]
id: AISM:0000177
name: pore canal {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pore canals: thin perforations of the cuticle.\""}
def: "The orifice that is contained by the cuticle and connects the inside of the insect with the outside, is tubular, and whose diameter is smaller than 100 nm." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-04"}
is_a: UBERON:0000161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! orifice
relationship: AISM:0000079 UBERON:0001002 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by cuticle
relationship: has_characteristic PATO:0001873 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cylindrical
relationship: RO:0002008 CL:0000066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epithelial cell
property_value: curator_notes "Should coincide with 'exactly one' epithelial cell, but that violates OWL specs." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-26"}

[Term]
id: AISM:0000178
name: acantha {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Acanthae: hairs without sockets, one per hypodermal cell.\""}
def: "The solid cuticular protrusion that coincides with only one epidermal cell (smaller than the diameter of the epidermal cell)." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-04"}
is_a: AISM:0000028 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! solid cuticular protrusion
relationship: part_of AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: RO:0002008 CL:0000362 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with epidermal cell
property_value: curator_notes "Should coincide with 'exactly one' epithelial cell, but that violates OWL specs." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-26"}

[Term]
id: AISM:0000180
name: tergal carina {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"}
def: "The cuticular carina on a tergite (or notum)." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"}
is_a: AISM:0000501 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"} ! cuticular carina
relationship: part_of AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"} ! notum

[Term]
id: AISM:0000181
name: tibial spur {creation_date="2025-03-17", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The cuticular spur that is continuous with the distal margin of the tibia." [] {creation_date="2025-03-17", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000040 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-17"} ! cuticular spur

[Term]
id: AISM:0000185
name: sensillum chaeticum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensillum chaeticum: shorter than sensillum trichodeum, thick-walled.\""}
def: "The hairlike seta that is short and thick walled." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-08"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_characteristic PATO:0002228 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! acuminate
relationship: has_part AISM:0000039 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular seta

[Term]
id: AISM:0000186
name: sensillum trichodeum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensillum trichodeum: hair-like sensilla, seta associated with sensory cell.\""}
def: "The cuticular seta that is elongated and acuminate." [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_characteristic PATO:0001154 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elongated
relationship: has_characteristic PATO:0002228 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! acuminate
relationship: has_part AISM:0000039 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular seta
relationship: has_part AISM:0000039 {IAO:0000232="Modified 2023-01-11: added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular seta
property_value: curator_notes "Hairlike seta that is long." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-08"}

[Term]
id: AISM:0000187
name: sensillum coeloconicum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensillum coeloconicum: sensillum with modified seta in a cavity, with narrowed external opening of surrounding cuticle.\""}
def: "Seta that is located in the middle of a depression with narrowed external opening." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-08"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla

[Term]
id: AISM:0000188
name: apodeme {AISM:0000171="Klass K-D (2001) The female abdomen of the viviparous earwig Hemimerus vosseleri (Insecta: Dermaptera: Hemimeridae), with a discussion of the postgenital abdomen of Insecta. Zoological Journal of the Linnean Society 131: 251–307. \n\nhttps://doi.org/10.1111/j.1096-3642.2001.tb02239.x \n\n\"tendon is used herein to designate sclerotized internal cuticular projections\"", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Apodeme: solid cuticular invagination serving as muscle insertion area.\""}
def: "The solid cuticular invagination of a sclerite." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000000 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular internal depression
relationship: has_characteristic PATO:0001873 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cylindrical
relationship: part_of AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite

[Term]
id: AISM:0000189
name: sensillum basiconicum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensillum basiconicum: sensillum with rounded, conical seta.\""}
def: "The seta that is conical." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_characteristic PATO:0002021 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conical
relationship: has_part AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular seta

[Term]
id: AISM:0000190
name: antennifer {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Antennifer: small cephalic process articulating with the antenna.\""}
def: "The cuticular protrusion of the head capsule thag is continuous with the antenniferal-scapal conjunctiva and adjacent to the cuticle of the scapus" [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000008 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular protrusion
relationship: adjacent_to AISM:0000113 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! scapus
relationship: continuous_with AISM:0004007 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antenniferal-scapal conjunctiva
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
property_value: curator_notes "The cuticular protrusion (process, protuberace) that bears the cranial articular surface of the cranio-antennal articulation." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-08"}

[Term]
id: AISM:0000191
name: tentorium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tentorium: cephalic endoskeleton, usually composed of paired anterior, posterior and dorsal tentorial arms and a transverse tentorial bridge (corpotentorium).\""}
def: "The solid, paired, branching cuticular invagination of the head capsule that is attached to the antenna and the mouthparts via muscles." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000136 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! branching cuticular invagination
is_a: AISM:0000188 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! apodeme
is_a: UBERON:0000061 ! anatomical structure
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! bilaterally paired
relationship: part_of AISM:0000019 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! head capsule
property_value: curator_notes "The paired apophysis that connects the posterior (ventral in prognathous head) and anterior (dorsal in prognathous head) walls of the head capsule and serves as site of isertion of atennal and mouthpart muscles." xsd:string {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-02-11"}

[Term]
id: AISM:0000192
name: tentorio-antennal muscle
def: "The insect cranial muscle that is attached to the tentorium and to the antenna." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000080 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect cranial muscle
relationship: attaches_to AISM:0000032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antenna
relationship: attaches_to AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0000193
name: cuticular pit {term:modified="2021-12-10"}
def: "The cuticular depression that corresponds to an apophysis." [] {creation_date="2021-02-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000156 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular fovea
relationship: has_characteristic PATO:0002078 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! hollow
relationship: RO:0002008 AISM:0000138 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! coincident with cuticular apophysis

[Term]
id: AISM:0000194
name: anterior tentorial pit {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anterior tentorial pit (or groove): externally visible invagination area and origin of anterior tentorial arm; adjacent with dorsolateral clypeal margin.\""}
def: "The tentorial pit that correspods to the anterior (dorsal in prognathous head) end of the tentorium." [] {creation_date="2021-02-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000196 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tentorial pit
relationship: adjacent_to AISM:0004038 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior tentorial arm

[Term]
id: AISM:0000195
name: posterior tentorial pit {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Posterior tentorial pit (or groove): externally visible invagination of posterior part of head capsule and origin of posterior tentorial arm; adjacent with foramen occipitale or gula.\""}
def: "The tentorial pit that correspods to the posterior (ventral in prognathous head) end of the tentorium." [] {creation_date="2021-02-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000196 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tentorial pit
relationship: continuous_with AISM:0004037 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! posterior tentorial arm

[Term]
id: AISM:0000196
name: tentorial pit
def: "The cuticular pit that correspods to the tentorium." [] {creation_date="2021-02-12", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", term:modified="2021-12-10"}
is_a: AISM:0000193 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular pit

[Term]
id: AISM:0000197
name: arthropod foramen
def: "The foramen encircled by insect region of cuticle." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: UBERON:0000161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! orifice
relationship: AISM:0000079 AISM:0000174 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by insect region of cuticle

[Term]
id: AISM:0000198
name: antennal foramen
def: "The arthropod foramen of the head capsule with the antennifer and surrounds the scapus via the antenniferal-scapal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "antennal socket" EXACT []
synonym: "torulus" EXACT [] {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"antennal socket = torulus = basal socket of antenna\""}
is_a: AISM:0000197 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! arthropod foramen
relationship: AISM:0000079 AISM:0000019 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by head capsule
relationship: AISM:0000079 AISM:0004007 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by antenniferal-scapal conjunctiva

[Term]
id: AISM:0000199
name: tibial carina {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-03-16"}
def: "The cuticular carina that is part of the tibia and parallel to the proximal-distal axis." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"}
is_a: AISM:0000501 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"} ! cuticular carina
relationship: parallel_to BSPO:0000015 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"} ! proximal-distal axis
relationship: part_of AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"} ! tibia

[Term]
id: AISM:0000200
name: gonocoxa IX {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The paired sclerite of the postabdomen that is attached to the abdominal tergite IX by the abdominal tergite IX-gonocoxa IX conjunctiva and is articulated with abdominal tergite IX." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-03-19"}
synonym: "second coxopodite" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
synonym: "second gonocoxite" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
synonym: "second valvifer" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
is_a: AISM:0004301 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonocoxite
relationship: continuous_with AISM:0000201 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IX-gonocoxa IX conjunctiva
property_value: IAO:0000589 "cuticle of gonocoxa IX" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0000201
name: abdominal tergite IX-gonocoxa IX conjunctiva
def: "The conjunctiva of the postabdomen that connects the abdominal tergite IX and the gonocoxa IX." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-03-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000200 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonocoxa IX
relationship: continuous_with AISM:0004117 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IX
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0000301
name: protarsomere {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The tarsomere that is part of the protarsus." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000074 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! tarsomere
relationship: part_of AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsus

[Term]
id: AISM:0000302
name: protarsomere 1 {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protarsomere distal to the protibia and encircled by the protibio-protarsal conjunctiva." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000301 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere
relationship: AISM:0000079 AISM:0004183 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! encircled by protibio-protarsal conjunctiva
relationship: distal_to AISM:0000067 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protibia

[Term]
id: AISM:0000303
name: protarsomere 2 {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protarsomere that is distal to the protarsomere 1 and is encircled by the protarsomere 1-protarsomere 2 conjunctiva." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000301 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere
relationship: AISM:0000079 AISM:0000319 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! encircled by protarsomere 1-protarsomere 2 conjunctiva
relationship: distal_to AISM:0000302 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere 1

[Term]
id: AISM:0000304
name: protarsomere 3 {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protarsomere that is distal to the protarsomere 2 and is encircled by the protarsomere 2-protarsomere 3 conjunctiva." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000301 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere
relationship: AISM:0000079 AISM:0000320 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! encircled by protarsomere 2-protarsomere 3 conjunctiva
relationship: distal_to AISM:0000303 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere 2

[Term]
id: AISM:0000305
name: protarsomere 4 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The protarsomere that is distal to the protarsomere 3 and is encircled by the protarsomere 3-protarsomere 4 conjunctiva." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000301 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere
relationship: AISM:0000079 AISM:0000321 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! encircled by protarsomere 3-protarsomere 4 conjunctiva
relationship: distal_to AISM:0000304 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere 3

[Term]
id: AISM:0000306
name: protarsomere 5 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The protarsomere that is distal to the protarsomere 4 and is encircled by the protarsomere 4-protarsomere 5 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000301 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere
relationship: AISM:0000079 AISM:0000322 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! encircled by protarsomere 4-protarsomere 5 conjunctiva
relationship: distal_to AISM:0000305 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! protarsomere 4

[Term]
id: AISM:0000307
name: mesotarsomere {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The tarsomere that is part of the mesotarsus." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000074 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! tarsomere
relationship: part_of AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus

[Term]
id: AISM:0000308
name: mesotarsomere 1 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsomere that is distal to the mesotibia and is encircled by the mesotibio-mesotarsal conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000307 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere
relationship: AISM:0000079 AISM:0004184 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotibio-mesotarsal conjunctiva
relationship: distal_to AISM:0000068 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotibia

[Term]
id: AISM:0000309
name: mesotarsomere 2 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsomere that is distal to the mesotarsomere 1 and is encircled by the mesotarsomere 1-mesotarsomere 2 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000307 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere
relationship: AISM:0000079 AISM:0000323 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 1-mesotarsomere 2 conjunctiva
relationship: distal_to AISM:0000308 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 1

[Term]
id: AISM:0000310
name: mesotarsomere 3 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsomere that is distal to the mesotarsomere 2 and is encircled by the mesotarsomere 2-mesotarsomere 3 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000307 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere
relationship: AISM:0000079 AISM:0000324 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 2-mesotarsomere 3 conjunctiva
relationship: distal_to AISM:0000309 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 2

[Term]
id: AISM:0000311
name: mesotarsomere 4 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsomere that is distal to the mesotarsomere 3 and is encircled by the mesotarsomere 3-mesotarsomere 4 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000307 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere
relationship: AISM:0000079 AISM:0000325 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 3-mesotarsomere 4 conjunctiva
relationship: distal_to AISM:0000310 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 3

[Term]
id: AISM:0000312
name: mesotarsomere 5 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsomere that is distal to the mesotarsomere 4 and is encircled by the mesotarsomere 4-mesotarsomere 5 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000307 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere
relationship: AISM:0000079 AISM:0000326 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 4-mesotarsomere 5 conjunctiva
relationship: distal_to AISM:0000311 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 4

[Term]
id: AISM:0000313
name: metatarsomere {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The tarsomere that is part of the metatarsus." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000074 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! tarsomere
relationship: part_of AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus

[Term]
id: AISM:0000314
name: metatarsomere 1 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsomere that is distal to the metatibia and is encircled by the metatibio-metatarsal conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000313 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere
relationship: AISM:0000079 AISM:0004185 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatibio-metatarsal conjunctiva
relationship: distal_to AISM:0000069 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatibia

[Term]
id: AISM:0000315
name: metatarsomere 2 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsomere that is distal to the metatarsomere 1 and is encircled by the metatarsomere 1-metatarsomere 2 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000313 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere
relationship: AISM:0000079 AISM:0000327 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 1-metatarsomere 2 conjunctiva
relationship: distal_to AISM:0000314 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 1

[Term]
id: AISM:0000316
name: metatarsomere 3 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsomere that is distal to the metatarsomere 2 and is encircled by the metatarsomere 2-metatarsomere 3 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000313 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere
relationship: AISM:0000079 AISM:0000328 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 2-metatarsomere 3 conjunctiva
relationship: distal_to AISM:0000315 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 2

[Term]
id: AISM:0000317
name: metatarsomere 4 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsomere that is distal to the metatarsomere 3 and is encircled by the metatarsomere 3-metatarsomere 4 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000313 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere
relationship: AISM:0000079 AISM:0000329 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 3-metatarsomere 4 conjunctiva
relationship: distal_to AISM:0000316 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 3

[Term]
id: AISM:0000318
name: metatarsomere 5 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsomere that is distal to the metatarsomere 4 and is encircled by the metatarsomere 4-metatarsomere 5 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000313 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere
relationship: AISM:0000079 AISM:0000330 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 4-metatarsomere 5 conjunctiva
relationship: distal_to AISM:0000317 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 4

[Term]
id: AISM:0000319
name: protarsomere 1-protarsomere 2 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the protarsus, is encircled by protarsomere 2 and encircles protarsomere 2." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000303 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles protarsomere 2
relationship: AISM:0000079 AISM:0000302 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by protarsomere 1
relationship: part_of AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsus

[Term]
id: AISM:0000320
name: protarsomere 2-protarsomere 3 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the protarsus, is encircled by protarsomere 2 and encircles protarsomere 3." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000304 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles protarsomere 3
relationship: AISM:0000079 AISM:0000303 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by protarsomere 2
relationship: part_of AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsus

[Term]
id: AISM:0000321
name: protarsomere 3-protarsomere 4 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the protarsus, is encircled by protarsomere 3 and encircles protarsomere 4." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000305 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles protarsomere 4
relationship: AISM:0000079 AISM:0000304 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by protarsomere 3
relationship: part_of AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsus

[Term]
id: AISM:0000322
name: protarsomere 4-protarsomere 5 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the protarsus, is encircled by protarsomere 4 and encircles protarsomere 5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000306 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles protarsomere 5
relationship: AISM:0000079 AISM:0000305 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by protarsomere 4
relationship: part_of AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsus

[Term]
id: AISM:0000323
name: mesotarsomere 1-mesotarsomere 2 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the mesotarsus, is encircled by mesotarsomere 1 and encircles mesotarsomere 2." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000309 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles mesotarsomere 2
relationship: AISM:0000079 AISM:0000308 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 1
relationship: part_of AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus

[Term]
id: AISM:0000324
name: mesotarsomere 2-mesotarsomere 3 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the mesotarsus, is encircled by mesotarsomere 2 and encircles mesotarsomere 3." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000310 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles mesotarsomere 3
relationship: AISM:0000079 AISM:0000309 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 2
relationship: part_of AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus

[Term]
id: AISM:0000325
name: mesotarsomere 3-mesotarsomere 4 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the mesotarsus, is encircled by mesotarsomere 3 and encircles mesotarsomere 4." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000311 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles mesotarsomere 4
relationship: AISM:0000079 AISM:0000310 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 3
relationship: part_of AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus

[Term]
id: AISM:0000326
name: mesotarsomere 4-mesotarsomere 5 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the mesotarsus, is encircled by mesotarsomere 4 and encircles mesotarsomere 5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000312 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles mesotarsomere 5
relationship: AISM:0000079 AISM:0000311 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by mesotarsomere 4
relationship: part_of AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus

[Term]
id: AISM:0000327
name: metatarsomere 1-metatarsomere 2 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the metatarsus, is encircled by metatarsomere 1 and encircles metatarsomere 2." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000315 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles metatarsomere 2
relationship: AISM:0000079 AISM:0000314 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 1
relationship: part_of AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus

[Term]
id: AISM:0000328
name: metatarsomere 2-metatarsomere 3 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the metatarsus, is encircled by metatarsomere 2 and encircles metatarsomere 3." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000316 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles metatarsomere 3
relationship: AISM:0000079 AISM:0000315 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 2
relationship: part_of AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus

[Term]
id: AISM:0000329
name: metatarsomere 3-metatarsomere 4 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the metatarsus, is encircled by metatarsomere 3 and encircles metatarsomere 4." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000317 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles metatarsomere 4
relationship: AISM:0000079 AISM:0000316 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 3
relationship: part_of AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus

[Term]
id: AISM:0000330
name: metatarsomere 4-metatarsomere 5 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the metatarsus, is encircled by metatarsomere 4 and encircles metatarsomere 5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000318 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles metatarsomere 5
relationship: AISM:0000079 AISM:0000317 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by metatarsomere 4
relationship: part_of AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus

[Term]
id: AISM:0000331
name: protarsus with 5 protarsomeres {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The protarsus with protarsomeres 1-5." [] {term:modified="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsus
relationship: has_part AISM:0000302 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsomere 1
relationship: has_part AISM:0000303 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsomere 2
relationship: has_part AISM:0000304 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsomere 3
relationship: has_part AISM:0000305 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsomere 4
relationship: has_part AISM:0000306 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! protarsomere 5

[Term]
id: AISM:0000332
name: mesotarsus with 5 mesotarsomeres {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The mesotarsus that is composed by mesotarsomeres 1-5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0004189 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsus
relationship: has_part AISM:0000308 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 1
relationship: has_part AISM:0000309 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 2
relationship: has_part AISM:0000310 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 3
relationship: has_part AISM:0000311 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 4
relationship: has_part AISM:0000312 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! mesotarsomere 5

[Term]
id: AISM:0000333
name: metatarsus with 5 metatarsomeres {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The metatarsus that is composed by metatarsomeres 1-5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0004188 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsus
relationship: has_part AISM:0000314 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 1
relationship: has_part AISM:0000315 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 2
relationship: has_part AISM:0000316 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 3
relationship: has_part AISM:0000317 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 4
relationship: has_part AISM:0000318 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! metatarsomere 5

[Term]
id: AISM:0000334
name: flagellomere 2 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 1 and is encircled by the flagellomere 1-flagellomere 2 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 4" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000344 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 1-flagellomere 2 conjunctiva
relationship: distal_to AISM:0000117 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 1

[Term]
id: AISM:0000335
name: flagellomere 3 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 2 and is encircled by the flagellomere 2-flagellomere 3 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 5" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000343 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 2-flagellomere 3 conjunctiva
relationship: distal_to AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 2

[Term]
id: AISM:0000336
name: flagellomere 4 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 3 and is encircled by the flagellomere 3-flagellomere 4 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 6" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000345 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 3-flagellomere 4 conjunctiva
relationship: distal_to AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 3

[Term]
id: AISM:0000337
name: flagellomere 5 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 4 and is encircled by the flagellomere 4-flagellomere 5 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 7" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000346 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 4-flagellomere 5 conjunctiva
relationship: distal_to AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 4

[Term]
id: AISM:0000338
name: flagellomere 6 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 5 and is encircled by the flagellomere 5-flagellomere 6 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 8" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000347 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 5-flagellomere 6 conjunctiva
relationship: distal_to AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 5

[Term]
id: AISM:0000339
name: flagellomere 7 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 6 and is encircled by the flagellomere 6-flagellomere 7 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 9" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000348 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 6-flagellomere 7 conjunctiva
relationship: distal_to AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 6

[Term]
id: AISM:0000340
name: flagellomere 8 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 7 and is encircled by the flagellomere 7-flagellomere 8 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 10" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000349 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 7-flagellomere 8 conjunctiva
relationship: distal_to AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 7

[Term]
id: AISM:0000341
name: flagellomere 9 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to the flagellomere 8 and is encircled by the flagellomere 8-flagellomere 9 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 11" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000350 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 8-flagellomere 9 conjunctiva
relationship: distal_to AISM:0000340 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 8

[Term]
id: AISM:0000342
name: flagellomere 10 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The cuticle of the flagellomere that is distal to flagellomere 9 and is encircled by the flagellomere 9-flagellomere 10 conjunctiva." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
synonym: "antennomere 12" EXACT [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000116 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere
relationship: AISM:0000079 AISM:0000351 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 9-flagellomere 10 conjunctiva
relationship: distal_to AISM:0000341 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 9

[Term]
id: AISM:0000343
name: flagellomere 2-flagellomere 3 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 2 and encircles the flagellomere 3." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 3
relationship: AISM:0000079 AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 2
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000344
name: flagellomere 1-flagellomere 2 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 1 and encircles the flagellomere 2." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 2
relationship: AISM:0000079 AISM:0000117 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 1
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000345
name: flagellomere 3-flagellomere 4 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 3 and encircles the flagellomere 4." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 4
relationship: AISM:0000079 AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 3
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000346
name: flagellomere 4-flagellomere 5 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 4 and encircles the flagellomere 5." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 5
relationship: AISM:0000079 AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 4
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000347
name: flagellomere 5-flagellomere 6 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 5 and encircles the flagellomere 6." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 6
relationship: AISM:0000079 AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 5
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000348
name: flagellomere 6-flagellomere 7 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 6 and encircles the flagellomere 7." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 7
relationship: AISM:0000079 AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 6
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000349
name: flagellomere 7-flagellomere 8 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 7 and encircles the flagellomere 8." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000340 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 8
relationship: AISM:0000079 AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 7
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000350
name: flagellomere 8-flagellomere 9 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 8 and encircles the flagellomere 9." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000341 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 9
relationship: AISM:0000079 AISM:0000340 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 8
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000351
name: flagellomere 9-flagellomere 10 conjunctiva {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The conjunctiva that is part of the antenna, is encircled by the flagellomere 9 and encircles the flagellomere 10." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! conjunctiva
relationship: AISM:0000078 AISM:0000342 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircles flagellomere 10
relationship: AISM:0000079 AISM:0000341 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! encircled by flagellomere 9
relationship: part_of AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna

[Term]
id: AISM:0000352
name: microreticulate {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "A structural quality inhering in a bearer by virtue of the bearer's having its surface covered with microscopic cuticular grooves forming a network." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000353 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! reticulate
relationship: has_part AISM:0000157 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! cuticular groove

[Term]
id: AISM:0000353
name: reticulate {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "A structural quality inhering in a bearer by virtue of the bearer's presenting on its surface a network of raised and interconnected wrinkles." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: PATO:0000150 {IAO:0000232="Modified 2024-02-14: moved as subclass of texture\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! texture

[Term]
id: AISM:0000354
name: isodiametrically microreticulate {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "A structural quality inhering in a bearer by virtue of the bearer's being microreticulate and having meshes of isometric diameter." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000352 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! microreticulate
is_a: PATO:0001573 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! isometrical

[Term]
id: AISM:0000355
name: abdomen with 7 sternites {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The insect abdomen that has abdominal sternites 1-7 and does not have abdominal sternite 8." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000109 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! insect abdomen
relationship: has_part AISM:0004100 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite I
relationship: has_part AISM:0004104 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite II
relationship: has_part AISM:0004105 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite III
relationship: has_part AISM:0004106 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite IV
relationship: has_part AISM:0004107 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite V
relationship: has_part AISM:0004108 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite VI
relationship: has_part AISM:0004109 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite VII

[Term]
id: AISM:0000356
name: abdomen with 8 sternites {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The insect abdomen that has abdominal sternites 1-8 and does not have abdominal sternite 9." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000109 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! insect abdomen
relationship: has_part AISM:0004100 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite I
relationship: has_part AISM:0004104 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite II
relationship: has_part AISM:0004105 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite III
relationship: has_part AISM:0004106 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite IV
relationship: has_part AISM:0004107 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite V
relationship: has_part AISM:0004108 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite VI
relationship: has_part AISM:0004109 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite VII
relationship: has_part AISM:0004110 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! abdominal sternite VIII

[Term]
id: AISM:0000357
name: antenna with 8 antennomeres {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The antenna that has scapus, pedicellus, and flagellomeres 1-6, and does not have flagellomere 7." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna
relationship: has_part AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 2
relationship: has_part AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 3
relationship: has_part AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 4
relationship: has_part AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 5
relationship: has_part AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 6

[Term]
id: AISM:0000358
name: antenna with 9 antennomeres {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
def: "The antenna that has scapus, pedicellus, and flagellomeres 1-7, and does not have flagellomere 8." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
is_a: AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna
relationship: has_part AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 2
relationship: has_part AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 3
relationship: has_part AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 4
relationship: has_part AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 5
relationship: has_part AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 6
relationship: has_part AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 7

[Term]
id: AISM:0000359
name: clypeal tooth {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular protrusion on the anterior margin of the clypeus." [] {term:modified="18-11-2023", creation_date="2023-03-28", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000407 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="18-11-2023", creation_date="2023-03-28"} ! cuticular tooth

[Term]
id: AISM:0000360
name: medial clypeal tooth {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The clypeal tooth that is not bilaterally paired and located in the medial region." [] {creation_date="2022-10-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000359 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! clypeal tooth
relationship: located_in BSPO:0000083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! medial region

[Term]
id: AISM:0000361
name: lateral clypeal tooth {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The clypeal tooth that is bilaterally paired and located in the lateral region." [] {creation_date="2022-10-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000359 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! clypeal tooth
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! bilaterally paired
relationship: located_in BSPO:0000082 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! lateral region

[Term]
id: AISM:0000362
name: lateral clypeal tooth 1 {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The lateral clypeal tooth that is lateral to the medial region." [] {creation_date="2022-10-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000361 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! lateral clypeal tooth
relationship: AISM:0000011 BSPO:0000083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! lateral_to medial region

[Term]
id: AISM:0000363
name: lateral clypeal tooth 2 {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The lateral clypeal tooth that is lateral to the lateral clypeal tooth 1." [] {creation_date="2022-10-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000361 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! lateral clypeal tooth
relationship: AISM:0000011 AISM:0000362 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! lateral_to lateral clypeal tooth 1

[Term]
id: AISM:0000364
name: lateral clypeal tooth 3 {creation_date="2022-10-30", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The lateral clypeal tooth that is lateral to the lateral clypeal tooth 2." [] {creation_date="2022-10-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000361 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2022-10-30"} ! lateral clypeal tooth
relationship: AISM:0000011 AISM:0000363 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! lateral_to lateral clypeal tooth 2

[Term]
id: AISM:0000365
name: tibial cuticular tooth {creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular protrusion of the cuticle of tibia." [] {term:modified="18-11-2023", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"}
is_a: AISM:0000407 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="18-11-2023", creation_date="2023-03-28"} ! cuticular tooth
relationship: part_of AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! tibia

[Term]
id: AISM:0000366
name: protibial cuticular tooth {creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular protrusion of the cuticle of protibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"}
is_a: AISM:0000365 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! tibial cuticular tooth
relationship: part_of AISM:0000067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! protibia

[Term]
id: AISM:0000367
name: dorsal protibial cuticular tooth {creation_date="2022-10-14", IAO:0000232="Modified and moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protibial cuticular tooth on the posterior margin." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2023-05-03", creation_date="2023-03-28", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000366 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! protibial cuticular tooth

[Term]
id: AISM:0000368
name: dorsal protibial cuticular tooth 1 {term:modified="2023-05-03", creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The dorsal protibial cuticular tooth that is proximal to the distal margin of the tibia." [] {creation_date="2023-03-30", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000367 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! dorsal protibial cuticular tooth

[Term]
id: AISM:0000369
name: dorsal protibial cuticular tooth 2 {term:modified="2023-05-03", creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The dorsal protibial cuticular tooth that is proximal to the dorsal protibial cuticular tooth 1." [] {creation_date="2023-03-30", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000367 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! dorsal protibial cuticular tooth
relationship: proximal_to AISM:0000368 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-30"} ! dorsal protibial cuticular tooth 1

[Term]
id: AISM:0000370
name: dorsal protibial cuticular tooth 3 {term:modified="2023-05-03", creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The dorsal protibial cuticular tooth that is proximal to the dorsal protibial cuticular tooth 2." [] {creation_date="2023-03-30", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000367 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! dorsal protibial cuticular tooth
relationship: proximal_to AISM:0000369 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-30"} ! dorsal protibial cuticular tooth 2

[Term]
id: AISM:0000371
name: dorsal protibial cuticular tooth 4 {term:modified="2023-05-03", creation_date="2022-10-14", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The dorsal protibial cuticular tooth that is proximal to the dorsal protibial cuticular tooth 3." [] {creation_date="2023-03-30", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2023-05-03", comment="", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000367 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-28"} ! dorsal protibial cuticular tooth
relationship: proximal_to AISM:0000370 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-03-30"} ! dorsal protibial cuticular tooth 3

[Term]
id: AISM:0000372
name: left paramere {IAO:0000232="Modified 2023-04-15: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-04"}
def: "The cuticle of the paramere that is located in the left side of the body." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-04"}
property_value: IAO:0000589 "cuticle of left paramere" xsd:string {creation_date="2023-04-15"}

[Term]
id: AISM:0000373
name: right paramere {IAO:0000232="Modified 2023-04-15: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-04"}
def: "The cuticle of the paramere that is located in the right side of the body." [] {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-04"}
property_value: IAO:0000589 "cuticle of right paramere" xsd:string {creation_date="2023-04-15"}

[Term]
id: AISM:0000374
name: tibial margin {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"}
def: "The anatomical margin that is part of the tibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2025-03-16"}
is_a: BSPO:0000678 ! distal margin

[Term]
id: AISM:0000375
name: anterior groove of tergite VIII {creation_date="2023-06-04", IAO:0000232="Modified and moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular groove that is parallel and distal to the proximal carina of tergite VIII." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000157 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! cuticular groove
relationship: distal_to AISM:0000377 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! proximal carina of tergite VIII
relationship: parallel_to AISM:0000377 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! proximal carina of tergite VIII

[Term]
id: AISM:0000376
name: interpunctural distance {creation_date="2023-06-04", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The distance between two cuticular punctures." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
property_value: curator_notes "Edited by jgiron https://orcid.org/0000-0002-0851-6883 \n2024-05-11\nTo make it a distance as opposed to an anatomical space and change 'adjacent to' for 'characteristic of'\nMatching existing definitions e.g. http://purl.obolibrary.org/obo/AGRO_00000318\n\nFormer definition based on suggestions at https://github.com/obophenotype/uberon/issues/3188" xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}

[Term]
id: AISM:0000377
name: proximal carina of tergite VIII {creation_date="2023-06-04", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular carina that is located on the proximal margin of the 8th tergite and is parallel to the left-right body axis." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
synonym: "pygidium basal ridge" EXACT [] {creation_date="2023-06-04", AISM:0000171="Tarasov, S. I., & Solodovnikov, A. Y. (2011). Phylogenetic analyses reveal reliable morphological markers to classify mega‐diversity in Onthophagini dung beetles (Coleoptera: Scarabaeidae: Scarabaeinae). Cladistics, 27(5), 490-528. https://doi.org/10.1111/j.1096-0031.2011.00351.x\n \nPage 526, character 30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000180 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! tergal carina
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! left-right axis
property_value: curator_notes "In Scarabaeinae, this carina (when present) is located in the proximalmost margin of the surface of the 8th tergite (pygidium) that is not covered by elytra." xsd:string {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"}

[Term]
id: AISM:0000378
name: granulate cuticular puncture {creation_date="2023-06-04", AISM:0000171="Orbigny, H. d’ (1913) [1913-1914]. Synopsis des Onthophagides d’Afrique. Annales de la Société entomologique de France, 82 : 1-742.\nhttps://www.biodiversitylibrary.org/page/8239919\n\n\"la ponctuation peut être râpeuse ou granuleuse, c'est-à-dire composée de points dont le bord antérieur s'élève en une aspérité irrégulière, ou en un granule arrondi qui ordinaireauent échancre plus ou moins ce bord antérieur\" p. 4", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular puncture that has a cuticular granule on its anterior margin." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000524 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! cuticular puncture

[Term]
id: AISM:0000379
name: ocellate cuticular puncture {creation_date="2023-06-04", AISM:0000171="Orbigny, H. d’ (1913) [1913-1914]. Synopsis des Onthophagides d’Afrique. Annales de la Société entomologique de France, 82 : 1-742.\n\nhttps://www.biodiversitylibrary.org/page/8239919\n\n\"... soit grands et à fond plat, ou ocellés, c'est-à-dire grands et à fond convexe, ou ombiliqués, c'est-à-dire grands, peu profonds et ayant dans l'intérieur un petit point plus profond\" p. 4", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular puncture that is flattened." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000380
name: posterior carina of tergite VIII {creation_date="2023-06-04", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular carina that is located along the posterior margin of abdominal tergite VIII." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
synonym: "ribordo del margine ventrale del pigidio" EXACT [] {creation_date="2023-06-04", AISM:0000171="Marchisio, R., & Zunino, M. E. (2012). Il genere Copris Müller. Tassonomia, filogenesi e note di zoogeografia (Vol. 2, pp. 1-176). world biodiversity association onlus.\n\nPage 26", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000180 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! tergal carina

[Term]
id: AISM:0000381
name: head margin at genoclypeal sulcus {creation_date="2023-06-04", IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin that is part of the anterior margin of the gena and of the lateral region of the posterior margin of the clypeus." [] {creation_date="2023-06-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: BSPO:0000006 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! anatomical margin
property_value: curator_notes "Corresponds with the region of the clypeal margin next to the distal end of the genoclypeal sulcus." xsd:string {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"}

[Term]
id: AISM:0000382
name: carina of vertex {IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-06", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular carina that is part of the vertex and parallel to the left-right body axis." [] {creation_date="2023-04-06", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! left-right axis

[Term]
id: AISM:0000383
name: clypeal carina {IAO:0000232="Moved from COLAO to AISM: 2023-05-08\ngmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-04-06", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular carina that is part of the clypeus and is parallel to the left-right body axis." [] {creation_date="2023-04-06", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-06-04"} ! left-right axis

[Term]
id: AISM:0000384
name: row of punctures {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "An anatomical row composed by cuticular punctures." [] {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: UBERON:0034926 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-03"} ! anatomical row
relationship: has_part AISM:0000524 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-03"} ! cuticular puncture

[Term]
id: AISM:0000385
name: clypeal margin {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin of the anterior region of clypeus." [] {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000386
name: genal margin {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin of the lateral region of the gena." [] {creation_date="2023-05-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000387
name: ventral conjunctiva of paramere {AISM:0000171="Rossini, M., Grebennikov, V., Merrien, T., Miraldo, A., Viljanen, H., & Tarasov, S. (2022). Paleogene forest fragmentation and out‐of‐Africa dispersal explain radiation of the Paleotropical dung beetle tribe Epactoidini trib. nov.(Coleoptera: Scarabaeinae). Systematic Entomology, 47(4), 655-667.\nhttps://doi.org/10.1111/syen.12564\n\nFigure 2d", creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The ventral region of the cuticle of paramere that has decreased thickness." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: has_characteristic PATO:0000592 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! decreased thickness

[Term]
id: AISM:0000388
name: left ventral conjunctiva of paramere {creation_date="2023-05-08", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The ventral conjunctiva of the left paramere." [] {creation_date="2023-05-08", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000387 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! ventral conjunctiva of paramere
relationship: part_of AISM:0000372 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! left paramere

[Term]
id: AISM:0000389
name: right ventral conjunctiva of paramere {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The ventral conjunctiva of the right paramere." [] {creation_date="2023-05-04", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000387 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! ventral conjunctiva of paramere
relationship: part_of AISM:0000373 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-04"} ! right paramere

[Term]
id: AISM:0000390
name: protibial apex adjacent to protibio-protarsal articulation {creation_date="2023-05-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The region of the cuticle part of the distal posterior region of protibia and adjacent to the protibio-protarsal articulation." [] {creation_date="2023-05-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000174 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-10"} ! insect region of cuticle
relationship: adjacent_to AISM:0000391 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-10"} ! insect protibio-protarsal articulation

[Term]
id: AISM:0000391
name: insect protibio-protarsal articulation {creation_date="2023-05-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The articulation between the protibia and the protarsus." [] {creation_date="2023-05-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000002 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-10"} ! insect articulation

[Term]
id: AISM:0000392
name: parameres {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The region of the insect cuticle that has left and right parameres." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000174 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! insect region of cuticle
relationship: has_part AISM:0000372 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! left paramere
relationship: has_part AISM:0000373 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! right paramere
property_value: curator_notes "This term has been created to indicate simultaneously left and right parameres, in order to be able to use on it the qualities \"symmetrical\" and \"asymmetrical\", which are not applicable to single parameres." xsd:string {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"}

[Term]
id: AISM:0000393
name: maxillary palpus with 4 palpomeres {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The maxillary palpus that has maxillary palpomeres I to IV but not maxillary palpomere V." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000051 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! maxillary palpus
relationship: has_part AISM:0002037 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! maxillary palpomere I
relationship: has_part AISM:0002038 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! maxillary palpomere II
relationship: has_part AISM:0002039 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! maxillary palpomere III
relationship: has_part AISM:0002040 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! maxillary palpomere IV

[Term]
id: AISM:0000394
name: labial palpomere I {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The labial palpomere that is adjacent to the distal margin of the palpiger." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000060 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere
relationship: AISM:0000079 AISM:0004017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! encircled by palpigero-palpal conjunctiva

[Term]
id: AISM:0000395
name: labial palpomere II {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The labial palpomere that is adjacent to the distal margin of the labial palpomere I." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000060 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere

[Term]
id: AISM:0000396
name: labial palpomere III {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The labial palpomere that is adjacent to the distal margin of the labial palpomere II." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000060 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere

[Term]
id: AISM:0000397
name: labial palpus with 3 palpomeres {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The labial palpus that has labial palpomeres I to III." [] {creation_date="2023-05-30", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000024 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpus
relationship: has_part AISM:0000394 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere I
relationship: has_part AISM:0000395 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere II
relationship: has_part AISM:0000396 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-30"} ! labial palpomere III

[Term]
id: AISM:0000405
name: antero-distal margin {creation_date="2023-11-17", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin that overlaps with the distal side and the anterior side." [] {creation_date="2023-11-17", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: BSPO:0000671 ! anterior margin
is_a: BSPO:0000678 ! distal margin

[Term]
id: AISM:0000406
name: postero-distal margin {creation_date="2023-11-17", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin that overlaps with the distal side and the posterior side." [] {creation_date="2023-11-17", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: BSPO:0000672 ! posterior margin
is_a: BSPO:0000678 ! distal margin

[Term]
id: AISM:0000407
name: cuticular tooth {creation_date="2023-11-18", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular protrusion that is located on an anatomical margin." [] {creation_date="2023-11-18", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000408
name: setigerous cuticular puncture {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular puncture that encircles a cuticular seta." [] {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000409
name: granulate setigerous cuticular puncture {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The setigerous cuticular puncture that has a cuticular granule on its anterior margin." [] {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000408 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-12-03"} ! setigerous cuticular puncture

[Term]
id: AISM:0000410
name: ocellate setigerous cuticular puncture {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The setigerous cuticular puncture that is flattened." [] {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000411
name: simple setigerous cuticular puncture {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The setigerous cuticular puncture that is flattened and does not have a cuticular granule." [] {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000408 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-12-03"} ! setigerous cuticular puncture

[Term]
id: AISM:0000412
name: cuticle with setigerous punctures {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The region of the insect cuticle that is covered by a collection of setigerous cuticular punctures." [] {creation_date="2023-12-03", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000174 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-12-03"} ! insect region of cuticle
relationship: has_member AISM:0000408 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-12-03"} ! setigerous cuticular puncture
relationship: has_part UBERON:0034925 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-12-03"} ! anatomical collection

[Term]
id: AISM:0000413
name: distal region of tergite VIII {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The region of the cuticle of tergite VIII that is posterior to the posterior carina of tergite VIII and anterior to the tergite's distal margin." [] {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000174 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! insect region of cuticle
relationship: part_of AISM:0004097 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! abdominal tergite VIII
relationship: posterior_to AISM:0000380 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! posterior carina of tergite VIII

[Term]
id: AISM:0000414
name: clypeal margin between clypeal teeth 1 and 2 {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The bilaterally paired anatomical margin part of the anterior region of the clypeal margin that is lateral to lateral clypeal teeth 1 and medial to latera clypeal tooth 2." [] {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000385 ! clypeal margin
relationship: AISM:0000011 AISM:0000362 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! lateral_to lateral clypeal tooth 1
relationship: AISM:0000012 AISM:0000363 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! medial_to lateral clypeal tooth 2
relationship: has_quality PATO:0040024 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! bilaterally paired

[Term]
id: AISM:0000415
name: clypeal margin between clypeal teeth 1 {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The not bilaterally paired anatomical margin part of the of the anterior region of the clypeal margin that is adjacent to lateral clypeal tooth 1 but not adjacent to the medial clypeal tooth." [] {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000385 ! clypeal margin
relationship: adjacent_to AISM:0000362 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! lateral clypeal tooth 1

[Term]
id: AISM:0000416
name: clypeal margin between clypeal tooth 1 and medial clypeal tooth {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The bilaterally paired anatomical margin part of the anterior region of the clypeal margin that is lateral to lateral clypeal tooth 1 and medial to latera clypeal tooth 2." [] {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000385 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! clypeal margin
relationship: AISM:0000011 AISM:0000362 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! lateral_to lateral clypeal tooth 1
relationship: AISM:0000012 AISM:0000363 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! medial_to lateral clypeal tooth 2
relationship: has_quality PATO:0040024 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! bilaterally paired

[Term]
id: AISM:0000417
name: dorsal protibial margin between protibial teeth 1 and 2 {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to dorsal protibial cuticular tooth 1 and distal to dorsal protibial cuticular tooth 2." [] {creation_date="2025-02-21", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! tibial margin
relationship: distal_to AISM:0000369 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! dorsal protibial cuticular tooth 2
relationship: proximal_to AISM:0000368 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-21"} ! dorsal protibial cuticular tooth 1

[Term]
id: AISM:0000418
name: dorsal protibial margin between protibial teeth 2 and 3 {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to dorsal protibial cuticular tooth 2 and distal to dorsal protibial cuticular tooth 3." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial margin
relationship: distal_to AISM:0000370 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 3
relationship: proximal_to AISM:0000369 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 2

[Term]
id: AISM:0000419
name: dorsal protibial margin between protibial teeth 3 and 4 {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to dorsal protibial cuticular tooth 3 and distal to dorsal protibial cuticular tooth 4." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial margin
relationship: distal_to AISM:0000371 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 4
relationship: proximal_to AISM:0000370 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 3

[Term]
id: AISM:0000420
name: dorsal protibial margin proximal to protibial tooth 4 {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to dorsal protibial cuticular tooth 4 and distal to the profemoro-protibial conjunctiva." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial margin
relationship: distal_to AISM:0004179 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! profemoro-protibial conjunctiva
relationship: proximal_to AISM:0000371 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 4

[Term]
id: AISM:0000421
name: dorsal protibial margin between protibial spur and protibial tooth 1 {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to the protibial spur and distal to the dorsal protibial cuticular tooth 1." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial margin
relationship: distal_to AISM:0000368 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 1
relationship: proximal_to AISM:0000371 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! dorsal protibial cuticular tooth 4

[Term]
id: AISM:0000422
name: protibial spur {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular spur that is encircled by the protibio-protarsal spur conjunctiva." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000181 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial spur
relationship: AISM:0000079 AISM:0000423 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! encircled by protibio-protibial spur conjunctiva

[Term]
id: AISM:0000423
name: protibio-protibial spur conjunctiva {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The conjunctiva that enricles the protibial spur and is encircled by the protibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! conjunctiva
relationship: AISM:0000078 AISM:0000422 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! encircles protibial spur
relationship: AISM:0000079 AISM:0000067 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! encircled by protibia

[Term]
id: AISM:0000424
name: mesotibial carina {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The tibial carina that is part of the mesotibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000199 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial carina
relationship: part_of AISM:0000068 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! mesotibia

[Term]
id: AISM:0000425
name: metatibial carina {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The tibial carina that is part of the metatibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000199 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! tibial carina
relationship: part_of AISM:0000069 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! metatibia

[Term]
id: AISM:0000426
name: mesotibial posteroventral carina {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial carina that is located in the postero-ventral region of the mesotibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000424 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! mesotibial carina

[Term]
id: AISM:0000427
name: mesotibial anteroventral carina {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial carina that is located in the antero-ventral region of the mesotibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000424 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! mesotibial carina

[Term]
id: AISM:0000428
name: mesotibial anterodorsal carina {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial carina that is located in the antero-dorsal region of the mesotibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000424 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! mesotibial carina

[Term]
id: AISM:0000429
name: mesotibial posterodorsal carina {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial carina that is located in the postero-dorsal region of the mesotibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000424 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! mesotibial carina

[Term]
id: AISM:0000430
name: metatibial posteroventral carina {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial carina that is located in the antero-dorsal region of the mesotibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000425 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! metatibial carina

[Term]
id: AISM:0000431
name: metatibial anteroventral carina {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The metatibial carina that is located in the postero-ventral region of the metatibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000425 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! metatibial carina

[Term]
id: AISM:0000432
name: metatibial anterodorsal carina {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The metatibial carina that is located in the antero-dorsal region of the metatibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000425 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! metatibial carina

[Term]
id: AISM:0000433
name: metatibial posterodorsal carina {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The metatibial carina that is located in the postero-dorsal region of the metatibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000425 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! metatibial carina

[Term]
id: AISM:0000434
name: mesotibial spur {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular spur encircled by the mesotibio-mesotibial spur conjunctiva." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000181 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! tibial spur
relationship: AISM:0000079 AISM:0000436 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! encircled by mesotibio-mesotibial spur conjunctiva

[Term]
id: AISM:0000435
name: metatibial spur {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The cuticular spur encircled by the metatibio-metatibial spur conjunctiva." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000181 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! tibial spur
relationship: AISM:0000079 AISM:0000437 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! encircled by metatibio-metatibial spur conjunctiva

[Term]
id: AISM:0000436
name: mesotibio-mesotibial spur conjunctiva {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The conjunctiva that enricles the mesotibial spur and is encircled by the mesotibia." [] {creation_date="2025-02-27", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! conjunctiva
relationship: AISM:0000078 AISM:0000434 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! encircles mesotibial spur
relationship: AISM:0000079 AISM:0000068 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-02-27"} ! encircled by mesotibia

[Term]
id: AISM:0000437
name: metatibio-metatibial spur conjunctiva {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The conjunctiva that enricles the metatibial spur and is encircled by the metatibia." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000004 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! conjunctiva
relationship: AISM:0000078 AISM:0000435 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! encircles metatibial spur
relationship: AISM:0000079 AISM:0000069 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! encircled by metatibia

[Term]
id: AISM:0000438
name: line connecting anterior margins of eyes {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical line parallel to the left-right body axis that is adjacent to the anterior margins of the eyes." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! left-right axis

[Term]
id: AISM:0000439
name: line connecting posterior margins of eyes {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical line parallel to the left-right body axis that is adjacent to the posterior margins of the eyes." [] {creation_date="2025-03-10", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-10"} ! left-right axis

[Term]
id: AISM:0000440
name: protarsus with 4 protarsomeres {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protarsus with protarsomeres 1-4, without protarsomere 5." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0004190 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protarsus
relationship: has_part AISM:0000302 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protarsomere 1
relationship: has_part AISM:0000303 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protarsomere 2
relationship: has_part AISM:0000304 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protarsomere 3
relationship: has_part AISM:0000305 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protarsomere 4

[Term]
id: AISM:0000441
name: protibial carina {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The tibial carina that is part of the protibia." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000199 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! tibial carina
relationship: part_of AISM:0000067 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protibia

[Term]
id: AISM:0000442
name: protibial anteroventral carina {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protibial carina that is located in the antero-ventral region of the protibia." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000441 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protibial carina

[Term]
id: AISM:0000443
name: protibial posteroventral carina {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The protibial carina that is located in the postero-ventral region of the protibia." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000441 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! protibial carina

[Term]
id: AISM:0000444
name: dorsal protibial margin proximal to protibial tooth 3 {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical margin part of the dorsal protibial margin that is proximal to dorsal protibial cuticular tooth 3 and distal to the profemoro-protibial conjunctiva." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000374 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! tibial margin
relationship: distal_to AISM:0004179 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! profemoro-protibial conjunctiva
relationship: proximal_to AISM:0000370 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! dorsal protibial cuticular tooth 3

[Term]
id: AISM:0000445
name: line adjacent to mesotarsomeres 2-4 of mesotarsus with 5 mesotarsomeres {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical line parallel to the proximal-distal axis that is adjacent to: 1) the proximal margin of mesotarsomere 2 of mesotarsus with 5 mesotarsomeres; and 2) the distal margin of mesotarsomere 4 of mesotarsus with 5 mesotarsomeres." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: BSPO:0001102 BSPO:0000015 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! parallel to proximal-distal axis

[Term]
id: AISM:0000446
name: dorsal mesotibial spur {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial spur that is located on the dorsal side of the tibial distal margin and is dorsal to the ventral protibial spur." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000447
name: ventral mesotibial spur {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The mesotibial spur that is located on the ventral side of the tibial distal margin and is ventral to the dorsal protibial spur." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}

[Term]
id: AISM:0000448
name: line adjacent to mesotarsomeres 2-5 of mesotarsus with 5 mesotarsomeres {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical line parallel to the proximal-distal axis that is adjacent to: 1) the proximal margin of mesotarsomere 2 of mesotarsus with 5 mesotarsomeres; and 2) the distal margin of mesotarsomere 5 of mesotarsus with 5 mesotarsomeres." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: BSPO:0001102 BSPO:0000015 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! parallel to proximal-distal axis

[Term]
id: AISM:0000449
name: line connecting medial margin of eyes {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The anatomical line parallel to the left-right body axis that is adjacent to the medial margins of the eyes." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
relationship: parallel_to BSPO:0000017 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! left-right axis

[Term]
id: AISM:0000450
name: membranous dorsodistal region of paramere {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
def: "The dorsodistal region of the cuticle of the paramere which has decreased thickness." [] {creation_date="2025-03-11", x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364"}
is_a: AISM:0000174 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! insect region of cuticle
relationship: has_characteristic PATO:0000592 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2025-03-11"} ! decreased thickness

[Term]
id: AISM:0000501
name: cuticular carina {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"an elevated ridge or keel, not necessarily high or acute\"", term:modified="2021-12-10"}
def: "The protrusion on a sclerite that is linear." [] {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330", creation_date="2021-05-06"}
is_a: AISM:0000008 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular protrusion
relationship: has_characteristic PATO:0001199 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! linear
relationship: part_of AISM:0000003 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! insect sclerite

[Term]
id: AISM:0000523
name: dorsal postabdomen
def: "Dorsal part of postabdomen." [] {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330", creation_date="2021-05-31"}
is_a: AISM:0004057 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! abdominal tergite
relationship: part_of AISM:0004056 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! postabdomen

[Term]
id: AISM:0000524
name: cuticular puncture {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"a small impression on the cuticle\"", term:modified="2021-12-10"}
def: "The cuticular fovea that is small." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000156 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular fovea
relationship: has_characteristic PATO:0000587 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! decreased size

[Term]
id: AISM:0000525
name: cuticular granule {term:modified="2021-12-10", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"a little grain or a minute grainlike elevation\"."}
def: "The cuticular protrusion of a sclerite that is small and convex." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000008 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular protrusion
relationship: has_characteristic PATO:0000587 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! decreased size
relationship: part_of AISM:0000003 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! insect sclerite

[Term]
id: AISM:0000526
name: cuticular tubercle {term:modified="2021-12-10", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"a small knoblike or rounded protuberance\""}
def: "The cuticular protrusion of a sclerite that is rounded (circular)." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000008 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular protrusion
relationship: has_characteristic PATO:0000411 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! circular
relationship: part_of AISM:0000003 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! insect sclerite

[Term]
id: AISM:0000527
name: cuticular spine {AISM:0000171="Richards AG, Richards PA (1979) The cuticular protuberances of insects. International Journal of Insect Morphology and Embryology 8: 143–157. \n\n\"Multicellular protuberances without differentiation of specialized cells [...] evaginations, non-movable\"", source="https://doi.org/10.1016/0020-7322(79)90013-8", term:modified="2021-12-10"}
def: "The cuticular protrusion of a sclerite that is pointed and narrow." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000008 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular protrusion
relationship: has_characteristic PATO:0000599 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-06-20"} ! decreased width
relationship: has_characteristic PATO:0002258 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! pointed
relationship: part_of AISM:0000003 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! insect sclerite

[Term]
id: AISM:0000528
name: granulated cuticle {term:modified="2021-12-10", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"covered with or made up of very small grains or granules\""}
def: "The region of cuticle that bears an anatomical collection that is composed of granules." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_member AISM:0000525 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular granule
relationship: has_part UBERON:0034925 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! anatomical collection

[Term]
id: AISM:0000529
name: punctate cuticle {term:modified="2021-12-10", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"set with fine, impressed points or punctures appearing as pin-pricks\""}
def: "The region of cuticle that bears an anatomical collection that is composed of punctures." [] {term:modified="20021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_member AISM:0000524 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular puncture
relationship: has_part UBERON:0034925 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! anatomical collection

[Term]
id: AISM:0000530
name: setose cuticle {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"furnished or covered with setae or stiff hairs\"", term:modified="2021-12-10"}
def: "The region of the cuticle that bears an anatomical collection that is composed of setae." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-07-21"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_member AISM:0000039 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular seta
relationship: has_part UBERON:0034925 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! anatomical collection

[Term]
id: AISM:0000531
name: conjunctival keel
def: "The cuticular evagination constituted by conjunctiva that is elongated." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
is_a: AISM:0000027 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular evagination
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! elongated
relationship: part_of AISM:0000004 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! conjunctiva

[Term]
id: AISM:0000532
name: conjunctival tubercle
def: "The cuticular evagination constituted by conjunctiva that is circular." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
is_a: AISM:0000027 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! cuticular evagination
relationship: has_characteristic PATO:0000411 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! circular
relationship: part_of AISM:0000004 {x_1.1:contributor="starasov https://orcid.org/0000-0001-5237-2330"} ! conjunctiva

[Term]
id: AISM:0000534
name: conjunctival fold
def: "The cuticular depression constituted by conjunctiva that is elongated." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
is_a: AISM:0000005 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular depression
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! elongated
relationship: part_of AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva

[Term]
id: AISM:0002002
name: anterior tentorio-scapal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior or dorsal tentorial arms\"\n\n\"Insertion: Anterior (ventral) basal margin of the scape\""}
def: "The cranio-antennal muscle that is attached to the dorsal tentorial arm and the proximal margin of the scapus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle
relationship: attaches_to AISM:0004039 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal tentorial arm

[Term]
id: AISM:0002003
name: posterior tentorio-scapal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior or dorsal tentorial arms\"\n\n\"Insertion: Posterior (dorsal) basal margin of the scape\""}
def: "The cranio-antennal muscle that is attached to the dorsal or anterior tentorial arm and the proximo-dorsal margin of the scapus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle

[Term]
id: AISM:0002004
name: lateral tentorio-scapal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior or dorsal tentorial arms\"\n\n\"Insertion: Lateral basal margin of the scape\""}
def: "The cranio-antennal muscle that extends between the dorsal or anterior tentorial arm and the proximo-lateral margin of the scapus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle

[Term]
id: AISM:0002005
name: medial tentorio-scapal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior or dorsal tentorial arms\"\n\n\"Insertion: Mesal basal margin of the scape\""}
def: "The cranio-antennal muscle that is attached to the dorsal or anterior tentorial arm and the proximal margin of the scapus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle
relationship: attaches_to AISM:0004039 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal tentorial arm

[Term]
id: AISM:0002006
name: fronto-pedicellar muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Frons\"\n\n\"Insertion: Lateral edge of the pedicel\""}
def: "The cranio-antennal muscle that is attached to the frons and the pedicellus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle
relationship: attaches_to AISM:0000115 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! pedicellus
relationship: attaches_to AISM:0004020 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frons

[Term]
id: AISM:0002007
name: lateral scapo-pedicellar muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Dorsal or dorsolateral wall of the scape\"\n\n\"Insertion: Lateral or dorsolateral wall of the pedicel\""}
def: "The cranio-antennal muscle that is attached to the dorsal or dorsolateral regions of the scapus and the lateral or dorsolateral regions of the pedicellus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle

[Term]
id: AISM:0002008
name: medial scapo-pedicellar muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesal or dorsomesal wall of the scape\"\n\n\"Insertion: Mesal, anteriomesal or anterior edge of the pedicel\""}
def: "The cranio-antennal muscle that is attached to the scapus and the pedicellus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000081 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-antennal muscle
relationship: attaches_to AISM:0000113 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! scapus
relationship: attaches_to AISM:0000115 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! pedicellus

[Term]
id: AISM:0002009
name: frontolabral muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesally on the frons or on the antennal base\"\n\n\"Insertion: Mesally on the outer basal wall of the labrum\""}
def: "The cranio-labral muscle that is attached to the frons and the labrum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000084 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labral muscle
relationship: attaches_to AISM:0004020 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frons

[Term]
id: AISM:0002010
name: epistoepipharyngeal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Epistomal sulcus\"\n\n\"Insertion: Basal labral wall\""}
def: "The cranio-labral muscle that is attached to the frontoclypeal ridge and the labrum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000084 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labral muscle
relationship: attaches_to AISM:0004034 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frontoclypeal ridge

[Term]
id: AISM:0002011
name: frontoepypharyngeal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesally on the frons or on the antennal base,\nusually on the same level as musculus\nfrontolabralis\"\n\n\"Insertion: Basal labral wall or tormae\""}
def: "The cranio-labral muscle that is attached to the frons and the tormae." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000084 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labral muscle
relationship: attaches_to AISM:0002012 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! torma
relationship: attaches_to AISM:0004020 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frons

[Term]
id: AISM:0002012
name: torma {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tormae: lateral apodemes of labral base\""}
def: "The apodeme at either side of the proximal margin of the labrum." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000188 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! apodeme

[Term]
id: AISM:0002013
name: transversal labral muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Ventral labral wall\"\n\n\"Insertion: Ventral labral wall of the other side\""}
def: "The cranio-labral muscle that extends betwen the sides of  the labrum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000084 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labral muscle

[Term]
id: AISM:0002014
name: internal cranio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Ventral, posterior, lateral and/or dorsal parts of\nthe head capsule and/or posterior and\nanterior tentorial arms\"\n\n\"Insertion: Tendon that inserts at the median edge of the\nmandible\""}
def: "The cranio-mandibular muscle that is attached to the head capsule and the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle

[Term]
id: AISM:0002017
name: posteroexternal cranio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Gena and postgena\"\n\n\"Insertion: Tendon that inserts at the lateral edge of the mandible\""}
def: "The cranio-mandibular muscle that extends between the gena and the lateral margin of the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! gena

[Term]
id: AISM:0002018
name: anteroexternal cranio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Gena, below the compound eye\"\n\n\"Insertion: With a tendon on the mandible, posterior to the anterior articulation complex\""}
def: "The cranio-mandibular muscle that is attached to the gena and the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! gena

[Term]
id: AISM:0002019
name: hypopharyngeal suspensorium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Suspensorium (=fulturae, hypopharyngeal arms, oral arms): sclerotized strengthening elements of proximal hypopharynx.\""}
def: "The hypopharyngeal sclerite on the proximal region of the hypopharynx." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2022-06-22"}
synonym: "fulturae" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043"}
synonym: "hypopharyngeal arms" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043"}
synonym: "oral arms" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043"}
is_a: AISM:0004275 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hypopharyngeal sclerite

[Term]
id: AISM:0002021
name: hypopharyngeomandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Small sclerite close to the loral arm\n(Thermobia), scleroticed arm that elongates\nthe loral arm (Neoptera)\"\n\n\"Insertion: Inner side of the lateral wall of the mandible\""}
def: "The cranio-mandibular muscle that is attached to the suspensorium and the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0002019 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! hypopharyngeal suspensorium

[Term]
id: AISM:0002022
name: superolateral tentorio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior and dorsal tentorial arm\"\n\n\"Insertion: Outer basal edge of the mandibular body, between processus paratentorialis and posterior articulation\""}
def: "The cranio-mandibular muscle that is attached to the dorsal tentorial arm and the proximal margin of the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004039 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal tentorial arm

[Term]
id: AISM:0002023
name: inferolateral tentorio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior tentorial arm\"\n\n\"Insertion: Ventral basal margin of the mandible\""}
def: "The cranio-mandibular muscle that extends between the anterior tentorial arm and the proximal-ventral margin of the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! anterior tentorial arm

[Term]
id: AISM:0002024
name: superomedial tentorio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior and dorsal tentorial arm below musculus tentoriomandibularis externus dorsalis\"\n\n\"Insertion: Upper inner end of the mandible, just below the posterior mandibular condyle\""}
def: "The cranio-mandibular muscle that is attached to the anterior tentorial arm and the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! anterior tentorial arm

[Term]
id: AISM:0002025
name: inferomedial tentorio-mandibular muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior tentorial arm, below musculus tentoriomandibularis lateralis superior\"\n\n\"Insertion: Mediodorsal wall of the mandibular cavity\""}
def: "The cranio-mandibular muscle that extends between the anterior tentorial arm and the dorso-medial region of the insect mandible." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000082 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-mandibular muscle
relationship: attaches_to AISM:0004038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! anterior tentorial arm

[Term]
id: AISM:0002026
name: insect cranio-maxillar muscle
def: "The somatic muscle that is attached to the head capsule and the insect maxilla." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: UBERON:0014895 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"} ! somatic muscle
relationship: attaches_to AISM:0000044 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect maxilla

[Term]
id: AISM:0002027
name: cranio-cardinal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Postgena and gena\"\n\n\"Insertion: Basal cardinal process\""}
def: "The insect cranio-maxillar muscle that is attached to the gena and the cardo." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000018 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cardo
relationship: attaches_to AISM:0004026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! gena

[Term]
id: AISM:0002028
name: cranio-lacinial muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Posterior part of the gena\"\n\n\"Insertion: Basal edge of lacinia\""}
def: "The insect cranio-maxillar muscle that is attached to the gena and the lacinia." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! lacinia
relationship: attaches_to AISM:0004026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! gena

[Term]
id: AISM:0002029
name: tentorio-cardinal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Tentorium\"\n\n\"Insertion: Distal part of the cardo, close to the carostipital\nsulcus\""}
def: "The insect cranio-maxillar muscle that is attached to the tentorium and the cardo." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000018 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cardo
relationship: attaches_to AISM:0000191 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorium

[Term]
id: AISM:0002030
name: anterior tentorio-stipital muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Tentorium\"\n\n\"Insertion: Stipital ridge\""}
def: "The insect cranio-maxillar muscle that is attached to the tentorium and the stipital ridge." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000191 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorium
relationship: attaches_to AISM:0002031 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipital ridge

[Term]
id: AISM:0002031
name: stipital ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043"}
def: "The ridge that is part of the stipes." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cuticular ridge
relationship: part_of AISM:0000111 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipes

[Term]
id: AISM:0002032
name: posterior tentorio-stipital muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Tentorium\"\n\n\"Insertion: Basally on the stipes, close to the stipitocardinal\nsuture\""}
def: "The insect cranio-maxillar muscle that is attached to the tentorium and the stipes." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000111 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipes
relationship: attaches_to AISM:0000191 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorium

[Term]
id: AISM:0002033
name: stipito-lacinial muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Lateral wall of the stipes, basal to the maxillary\npalpus\"\n\n\"Insertion: Basal edge of lacinia, in some cases common\ntendon with 0mx4\""}
def: "The insect cranio-maxillar muscle that is attached to the stipes and the lacinia." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! lacinia
relationship: attaches_to AISM:0000111 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipes

[Term]
id: AISM:0002034
name: stipito-galeal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Lateral wall of the stipes, basal to the maxillary\npalpus\"\n\n\"Insertion: Basal edge of galea\""}
def: "The insect cranio-maxillar muscle that is attached to the stipes and the galea." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000023 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! galea
relationship: attaches_to AISM:0000111 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipes

[Term]
id: AISM:0002035
name: stipito-palpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x"}
def: "The insect cranio-maxillar muscle that is attached to the stipes and the maxillary palpus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0000051 {def="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpus
relationship: attaches_to AISM:0000111 {def="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! stipes

[Term]
id: AISM:0002036
name: maxillary palpomere {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mere that is part of the maxillary palpus." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000073 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mere
relationship: part_of AISM:0000051 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpus
property_value: IAO:0000589 "cuticle of maxillary palpomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002037
name: maxillary palpomere I {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the maxillary palpomere that is attached to the distal margin of the palpiger and to the proximal margin of the maxillary palpomere II." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpomere
relationship: AISM:0000079 AISM:0004017 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by palpigero-palpal conjunctiva
property_value: IAO:0000589 "cuticle of maxillary palpomere I" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002038
name: maxillary palpomere II {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the maxillary palpomere that is attached to the distal margin of the maxillary palpomere I." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpomere
property_value: IAO:0000589 "cuticle of maxillary palpomere II" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002039
name: maxillary palpomere III {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the maxillary palpomere that is attached to the distal margin of the maxillary palpomere II." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpomere
property_value: IAO:0000589 "cuticle of maxillary palpomere III" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002040
name: maxillary palpomere IV {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the maxillary palpomere that is attached to the distal margin of the maxillary palpomere III." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpomere
property_value: IAO:0000589 "cuticle of maxillary palpomere IV" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002041
name: maxillary palpomere V {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the maxillary palpomere that is attached to the distal margin of the maxillary palpomere IV." [] {term:modified="2021-12-08", creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002036 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere
property_value: IAO:0000589 "cuticle of maxillary palpomere V" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0002042
name: first maxillar palpopalpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Basal edge of palpomere 1\"\n\n\"Insertion: Basal edge of palpomere 2\""}
def: "The insect cranio-maxillar muscle that is attached to the first maxillar palpomere and  the second maxillar palpomere." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0002037 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere I
relationship: attaches_to AISM:0002038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere II

[Term]
id: AISM:0002043
name: second maxillar palpopalpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesal edge of palpomere 2\"\n\n\"Insertion: Mesal edge of palpomere 3\""}
def: "The insect cranio-maxillar muscle that is attached to the second maxillar palpomere and  the third maxillar palpomere." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0002038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere II
relationship: attaches_to AISM:0002039 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere III

[Term]
id: AISM:0002044
name: third maxillar palpopalpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Basal edge of palpomere 3\"\n\n\"Insertion: Basal edge of palpomere 4\""}
def: "The insect cranio-maxillar muscle that is attached to the third maxillar palpomere and  the fourth maxillar palpomere." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0002039 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere III
relationship: attaches_to AISM:0002040 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere IV

[Term]
id: AISM:0002045
name: fourth maxillar palpopalpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesal edge of palpomere 4\"\n\n\"Insertion: Mesal edge of palpomere 5\""}
def: "The insect cranio-maxillar muscle that is attached to the fourth maxillar palpomere and  the fifth maxillar palpomere." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002026 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-maxillar muscle
relationship: attaches_to AISM:0002040 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere IV
relationship: attaches_to AISM:0002041 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! maxillary palpomere V

[Term]
id: AISM:0002047
name: postoccipitoglossal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Postoccipital phragma\"\n\n\"Insertion: glossa\""}
def: "The cranio-labial muscle that is attached to the postoccipital phragma and  the glossa." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000049 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! glossa
relationship: attaches_to AISM:0002049 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! postoccipital phragma

[Term]
id: AISM:0002048
name: phragma {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Phragma: large, ridge-shaped internal apodeme.\"\n\n\"Phragma (=antecosta): dorsal thoracic transverse ridge, attachment site of dorsal longitudinal indirect flight muscles.\" (p. 121)"}
def: "The internal apodeme that is continuous with the cuticle of the notum and is attached to a dorsal longitudinal muscle." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000188 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! apodeme
is_a: UBERON:0000061 ! anatomical structure
relationship: attaches_to AISM:0002066 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! dorsal longitudinal thoracic muscle
relationship: continuous_with AISM:0004128 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! notum
relationship: continuous_with UBERON:0001002 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cuticle

[Term]
id: AISM:0002049
name: postoccipital phragma {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x"}
def: "The phragma that is continuous with the postocciput." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002048 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! phragma
relationship: continuous_with AISM:0004045 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postocciput

[Term]
id: AISM:0002050
name: postoccipitopremental muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Postoccipital phragma, laterad to musculus\npostoccipitoparaglossalis\"\n\n\"Insertion: Posteriolateral angle of the prementum\""}
def: "The cranio-labial muscle that is attached to the postoccipital phragma and  the prementum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum
relationship: attaches_to AISM:0002049 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! postoccipital phragma

[Term]
id: AISM:0002051
name: tentorio-premental muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Posterior tentorial arms, cranium\"\n\n\"Insertion: Laterobasal edge of prementum\""}
def: "The cranio-labial muscle that is attached to the posterior tentorial arm and the prementum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum
relationship: attaches_to AISM:0004037 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! posterior tentorial arm

[Term]
id: AISM:0002052
name: tentorio-paraglossal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Posterior tentorial arms, postoccipital ridge or\ncranium\"\n\n\"Insertion: Paraglossa, close to the labial palp\""}
def: "The cranio-labial muscle that is attached to the posterior tentorial arm and the paraglossa." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000050 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! paraglossa
relationship: attaches_to AISM:0004037 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! posterior tentorial arm

[Term]
id: AISM:0002053
name: submentopremental muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mediobasal part of submentum or gula\"\n\n\"Insertion: Mediobasal edge of prementum, close to the gales\""}
def: "The cranio-labial muscle that is attached to the submentum and the prementum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum
relationship: attaches_to AISM:0004005 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! submentum

[Term]
id: AISM:0002054
name: submentomental muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: submentum\"\n\n\"Insertion: mentum\""}
def: "The cranio-labial muscle that is attached to the submentum and the mentum." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0004004 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect mentum
relationship: attaches_to AISM:0004005 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! submentum

[Term]
id: AISM:0002055
name: premento-paraglossal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesal on the basal edge of the prementum\"\n\n\"Insertion: Dorsobasal edge of paraglossa\""}
def: "The cranio-labial muscle that is attached to the prementum and the paraglossa." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000050 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! paraglossa
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum

[Term]
id: AISM:0002056
name: premento-glossal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Mesally on the prementum\"\n\n\"Insertion: Mediobasal edge of glossa\""}
def: "The cranio-labial muscle that is attached to the prementum and the glossa." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000049 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! glossa
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum

[Term]
id: AISM:0002057
name: premento-palpal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: prementum\"\n\n\"Insertion: labial palpus\""}
def: "The cranio-labial muscle that is attached to the prementum and the labial palpus." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0000083 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-labial muscle
relationship: attaches_to AISM:0000024 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! labial palpus
relationship: attaches_to AISM:0000057 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prementum

[Term]
id: AISM:0002058
name: cranio-hypopharyngeal muscle
def: "The somatic muscle that is attached to the head capsule and the hypopharynx." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: AISM:0000080 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranial muscle
relationship: attaches_to AISM:0000093 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! hypopharynx

[Term]
id: AISM:0002059
name: fronto-oral muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Frons\"\n\n\"Insertion: Oral arms of the suspensorial sclerites\""}
def: "The cranio-hypopharyngeal muscle that is attached to the frons and  the suspensorium." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002058 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-hypopharyngeal muscle
relationship: attaches_to AISM:0002019 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! hypopharyngeal suspensorium
relationship: attaches_to AISM:0004020 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frons

[Term]
id: AISM:0002060
name: tentorio-oral muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Anterior tentorial arm, epistomal sulcus or\nfrons close to epistomal sulcus\"\n\n\"Insertion: Oral arms of the suspensorial sclerites, well\nseperated from above\""}
def: "The cranio-hypopharyngeal muscle that is attached to the anterior tentorial arm and the suspensorium." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002058 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cranio-hypopharyngeal muscle
relationship: attaches_to AISM:0002019 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! hypopharyngeal suspensorium
relationship: attaches_to AISM:0004038 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! anterior tentorial arm

[Term]
id: AISM:0002061
name: insect cranio-tentorial muscle
def: "The somatic muscle that is attached to the head capsule and the tentorium." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"}
is_a: UBERON:0014895 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"} ! somatic muscle
relationship: attaches_to AISM:0000191 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorium

[Term]
id: AISM:0002062
name: tentorio-frontal muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Laterad on the anterior corpotentorium\"\n\n\"Insertion: Frons\""}
def: "The insect cranio-antennal muscle that is attached to the tentorial bridge and the frons." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002061 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-tentorial muscle
relationship: attaches_to AISM:0004020 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! frons
relationship: attaches_to AISM:0004024 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorial bridge

[Term]
id: AISM:0002063
name: tentorio-tentorial muscle {AISM:0000171="Wipfler B, Machida R, Mueller B, Beutel RG (2011). On the head morphology of Grylloblattodea (Insecta) and the systematic position of the order, with a new nomenclature for the head muscles of Dicondylia. Systematic Entomology, 36(2), 241-266.\n\n https://doi.org/10.1111/j.1365-3113.2010.00556.x\n\n\"Origin: Ventrolaterad on the anterior corpotentorium\"\n\n\"Insertion: Mesad on the posterior tentorium\""}
def: "The insect cranio-antennal muscle that is attached to the tentorial bridge and the tentorium." [] {creation_date="2021-04-03", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002061 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect cranio-tentorial muscle
relationship: attaches_to AISM:0004024 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! tentorial bridge

[Term]
id: AISM:0002064
name: insect leg muscle
def: "The somatic muscle that is part of the insect leg." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: AISM:0002065 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect thoracic muscle
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0002065
name: insect thoracic muscle
def: "The somatic muscle that is part of the insect thorax." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2021-12-13"}
is_a: UBERON:0014895 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! somatic muscle
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0002066
name: dorsal longitudinal thoracic muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The insect thoracic muscle that is not fan-shaped and runs along the dorsal region, parallel to the anterior-posterior axis." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect thoracic muscle
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! anterior-posterior axis
relationship: part_of BSPO:0000079 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! dorsal region

[Term]
id: AISM:0002067
name: dorso-ventral thoracic muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The insect thoracic muscle that runs parallel to the dorsal-ventral axis." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002065 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect thoracic muscle
relationship: parallel_to BSPO:0000016 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! dorsal-ventral axis

[Term]
id: AISM:0002068
name: tergo-pleural muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The insect thoracic muscle that extends between the notum (or tergum) and the pleura." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: continuous_with AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0002069
name: sterno-pleural muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The insect thoracic muscle that extends between the sternum and the pleura." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect thoracic muscle
relationship: attaches_to AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron
relationship: attaches_to AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0002070
name: ventral-longitudinal muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The insect thoracic muscle that is not fan-shaped and runs along the ventral region, parallel to the anterior-posterior axis." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect thoracic muscle
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! anterior-posterior axis
relationship: part_of BSPO:0000084 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ventral region

[Term]
id: AISM:0002071
name: prophragma-occipital muscle {def="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"origin: prophragma\"\n\"insertion: postocciput\""}
def: "The dorsal longitudinal thoracic muscle that is attached to the prophragma and the postocciput." [] {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", creation_date="2021-04-06"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle
relationship: attaches_to AISM:0002076 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prophragma
relationship: attaches_to AISM:0004045 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! postocciput

[Term]
id: AISM:0002072
name: pronoto-occipital muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"origin: pronotum\"\n\n\"insertion: postocciput\""}
def: "The dorsal longitudinal thoracic muscle that is attached to the pronotum and the postocciput." [] {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", creation_date="2021-04-06"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle
relationship: attaches_to AISM:0000059 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! pronotum
relationship: attaches_to AISM:0004045 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! postocciput

[Term]
id: AISM:0002073
name: prophragma-cervical muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"origin: prophragma\"\n\"insertion: cervical sclerite\""}
def: "The dorsal longitudinal thoracic muscle that is attached to the prophragma and the cervical sclerite." [] {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", creation_date="2021-04-06"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle
relationship: attaches_to AISM:0002076 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prophragma
relationship: attaches_to AISM:0004141 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cervical sclerite

[Term]
id: AISM:0002074
name: dorsal cervico-occipital muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"origin: cervical sclerite\"\n\n\"insertion: postocciput\""}
def: "The dorsal longitudinal thoracic muscle that is attached to the cervical sclerite and the postocciput." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle
relationship: attaches_to AISM:0004045 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! postocciput
relationship: attaches_to AISM:0004141 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! cervical sclerite

[Term]
id: AISM:0002075
name: pronoto-phragmal muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"origin: pronotum\"\n\"insertion: prophragma\""}
def: "The dorsal longitudinal thoracic muscle that is attached to the pronotum and the prophragma." [] {creation_date="2021-04-04", x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle
relationship: attaches_to AISM:0000059 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! pronotum
relationship: attaches_to AISM:0002076 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prophragma

[Term]
id: AISM:0002076
name: prophragma
def: "The phragma of the mesonotum that attaches to muscles attached to the pronotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002048 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! phragma
relationship: part_of AISM:0000052 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! mesonotum

[Term]
id: AISM:0002078
name: anterior cervico-occipital muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"The dorsoventral muscle that arises from dorsolateral postocciput and inserts on anterior tip of first lateral cervical sclerite.\""}
def: "The dorsoventral thoracic muscle of the prothorax that is attached to the anterior margin of a cervical sclerite and the dorso-lateral region of the postocciput." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle
relationship: part_of AISM:0004125 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! prothorax

[Term]
id: AISM:0002079
name: anterior pronoto-cervical muscle {def="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"The dorsoventral muscle that arises from anterolateral pronotum and inserts on atypically on middle region of anterior propleural sclerite.\""}
def: "The dorsoventral thoracic muscle that extends between the antero-lateral region of the pronotum and the medial region of the propleuron." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle

[Term]
id: AISM:0002080
name: prophragma-tentorial muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The dorsoventral thoracic muscle that extends between the tentorium and the prophragma." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle
relationship: attaches_to AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium
relationship: attaches_to AISM:0002076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prophragma

[Term]
id: AISM:0002081
name: profurca-prophragmal muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"The dorsoventral muscle that arises from posterior face of proximal profurcal arm and inserts on lateral prophragma.\""}
def: "The dorsoventral thoracic muscle that extends between the profurca and the lateral region of the prophragma." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle
relationship: attaches_to AISM:0000143 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! profurca

[Term]
id: AISM:0002082
name: profurca-occipital muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The dorsoventral thoracic muscle that extends between the posterior region (occipital region) of the head capsule and the profurca." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle
relationship: attaches_to AISM:0000143 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! profurca

[Term]
id: AISM:0002083
name: prophragma-mesophragmal muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003\n\n\"The dorsal longitudinal muscle that arises from median prophragma and inserts on median mesophragma.\""}
def: "The dorsal longitudinal thoracic muscle that extends between the medial region of the prophragma and the medial region of the mesophragma." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002066 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorsal longitudinal thoracic muscle

[Term]
id: AISM:0002084
name: profurca-mesonotal muscle {AISM:0000171="Friedrich, F., & Beutel, R. G. (2008). The thorax of Zorotypus (Hexapoda, Zoraptera) and a new nomenclature for the musculature of Neoptera. \nArthropod Structure & Development, 37(1), 29-54.\n\nhttps://doi.org/10.1016/j.asd.2007.04.003"}
def: "The dorsoventral thoracic muscle that extends between the profurca and the mesonotum." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002067 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! dorso-ventral thoracic muscle
relationship: attaches_to AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: attaches_to AISM:0000143 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! profurca

[Term]
id: AISM:0002085
name: insect abdominal muscle
def: "The somatic muscle that is part of the insect abdomen." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: UBERON:0014895 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932", term:modified="2021-12-13"} ! somatic muscle
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0002086
name: lateral abdominal muscle {AISM:0000171="Klug, R., & Bradler, S. (2006). The pregenital abdominal musculature in phasmids and its implications for the basal phylogeny of Phasmatodea (Insecta: Polyneoptera). \nOrganisms Diversity & Evolution, 6(3), 171-184.\n\nhttps://doi.org/10.1016/j.ode.2005.08.004"}
def: "The insect abdominal muscle that runs along the lateral region, parallel to the dorsal-ventral axis." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002085 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect abdominal muscle
relationship: parallel_to BSPO:0000016 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! dorsal-ventral axis
relationship: part_of BSPO:0000082 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! lateral region

[Term]
id: AISM:0002087
name: ventral longitudinal abdominal muscle {AISM:0000171="Klug, R., & Bradler, S. (2006). The pregenital abdominal musculature in phasmids and its implications for the basal phylogeny of Phasmatodea (Insecta: Polyneoptera). \nOrganisms Diversity & Evolution, 6(3), 171-184.\n\nhttps://doi.org/10.1016/j.ode.2005.08.004"}
def: "The insect abdominal muscle that runs along the ventral region, parallel to the anterior-posterior axis." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002085 {x_1.1:contributor="lagonzalezmo https://orcid.org/0000-0002-9136-9932"} ! insect abdominal muscle
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior-posterior axis
relationship: part_of BSPO:0000084 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ventral region

[Term]
id: AISM:0002088
name: dorsal longitudinal abdominal muscle {AISM:0000171="Klug, R., & Bradler, S. (2006). The pregenital abdominal musculature in phasmids and its implications for the basal phylogeny of Phasmatodea (Insecta: Polyneoptera). \nOrganisms Diversity & Evolution, 6(3), 171-184.\n\nhttps://doi.org/10.1016/j.ode.2005.08.004"}
def: "The insect abdominal muscle that runs along the dorsal region, parallel to the anterior-posterior axis." [] {creation_date="2021-04-22", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002085 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdominal muscle
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior-posterior axis
relationship: part_of BSPO:0000079 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! dorsal region

[Term]
id: AISM:0004001
name: palpifer {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Palpifer: small separate element of stipes, bears the maxillary palp.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The sclerite of the insect maxilla that is attached to the cuticle of stipes by the stipito-palpiferal conjunctiva and to the cuticle of maxillary palpus by the palpifero-palpal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000051 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpus
relationship: adjacent_to AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: continuous_with AISM:0004010 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipito-palpiferal conjunctiva
relationship: continuous_with AISM:0004012 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifero-palpal conjunctiva
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla
property_value: IAO:0000589 "cuticle of palpifer" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004002
name: mental-premental conjunctiva
def: "The conjunctiva of the labium that connects the mentum and the prementum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: continuous_with AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004003
name: postmentum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postmentum: posterior main element of labium, posteriorly adjacent with foramen occipitale in hexapods without gula or hypostomal bridge; often separated into two sclerites, the anterior mentum and the posterior submentum.\""}
def: "The sclerite of the cuticle of labium that is cmposed of the submentum and the mentum, which are connected by the submental-mental conjunctiva" [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: has_part AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum
relationship: has_part AISM:0004005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submentum
relationship: has_part AISM:0004013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submental-mental conjunctiva
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004004
name: insect mentum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Mentum: intermediate part of labium, anterior part of postmentum; bears the prementum at its distal edge.\"", IAO:0000232="Modified 2023-01-20: to specify insect mentum.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The sclerite of the labium that is anterior to the submentum and posterior to the prementum, and attached to the prementum by the mental-premental conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: anterior_to AISM:0004005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submentum
relationship: continuous_with AISM:0004002 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mental-premental conjunctiva
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium
relationship: posterior_to AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum

[Term]
id: AISM:0004005
name: submentum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Submentum: posterior part of a divided postmentum.\""}
def: "The sclerite of the labium that is anteriorly attached to the mentum by the submental-mental conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: continuous_with AISM:0004013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submental-mental conjunctiva
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium
relationship: posterior_to AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum

[Term]
id: AISM:0004006
name: palpiger {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Palpiger: small separate element of prementum, bears the labial palp.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The sclerite of the cuticle of labium that is attached to the prementum by the premental-palpigeral conjunctiva and to the cuticle of labial palpus by the palpigero-palpal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-17"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labial palpus
relationship: adjacent_to AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: continuous_with AISM:0004014 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! premental-palpigeral conjunctiva
relationship: continuous_with AISM:0004017 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpigero-palpal conjunctiva
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium
property_value: IAO:0000589 "cuticle of palpiger" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004007
name: antenniferal-scapal conjunctiva
def: "The conjunctiva of the head capsule that connects the antennifer and the scapus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: AISM:0000078 AISM:0000113 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles scapus
relationship: continuous_with AISM:0000190 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antennifer
relationship: part_of AISM:0000112 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cranio-antennal conjunctiva

[Term]
id: AISM:0004008
name: interflagellomeral conjunctiva
def: "Is the conjunctiva of the antenna that connects a flagellomere and other flagellomere." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000116 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles flagellomere
relationship: AISM:0000079 AISM:0000116 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by flagellomere
relationship: part_of AISM:0000032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! antenna

[Term]
id: AISM:0004009
name: stipito-lacinial conjunctiva
def: "The conjunctiva of the insect maxilla that connects the stipes and the lacinia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000026 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! lacinia
relationship: continuous_with AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla

[Term]
id: AISM:0004010
name: stipito-palpiferal conjunctiva
def: "The conjunctiva of the insect maxilla that connects the stipes and the palpifer." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: continuous_with AISM:0004001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifer
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla

[Term]
id: AISM:0004011
name: stipito-galeal conjunctiva
def: "The conjunctiva of the insect maxilla that connects the stipes and the galea." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! galea
relationship: continuous_with AISM:0000111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! stipes
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla

[Term]
id: AISM:0004012
name: palpifero-palpal conjunctiva
def: "The conjunctiva of the insect maxilla that connects the palpifer and the maxillary palpus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000051 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! maxillary palpus
relationship: continuous_with AISM:0004001 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpifer
relationship: part_of AISM:0000044 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect maxilla

[Term]
id: AISM:0004013
name: submental-mental conjunctiva
def: "The conjunctiva of the labium that connects the submentum and the mentum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mentum
relationship: continuous_with AISM:0004005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submentum
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004014
name: premental-palpigeral conjunctiva
def: "The conjunctiva of the labium that connects the prementum and the palpiger." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: continuous_with AISM:0004006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpiger
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004015
name: premental-paraglossal conjunctiva
def: "The conjunctiva of the labium that connects the prementum and the paraglossa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000050 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraglossa
relationship: continuous_with AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004016
name: premental-glossal conjunctiva
def: "The conjunctiva of the labium that connects the prementum and the glossa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000049 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! glossa
relationship: continuous_with AISM:0000057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prementum
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004017
name: palpigero-palpal conjunctiva
def: "The conjunctiva of the labium that connects the palpiger and the labial palpus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labial palpus
relationship: continuous_with AISM:0004006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! palpiger
relationship: part_of AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labium

[Term]
id: AISM:0004018
name: clypeo-labral conjunctiva
def: "The conjunctiva of the insect maxilla that connects the clypeus and the labrum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labrum
relationship: continuous_with AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus

[Term]
id: AISM:0004019
name: clypeus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Clypeus: anteroventral part of head capsule; primarily separated from frons by transverse frontoclypeal strengthening ridge between anterior tentorial pits; usually bearing the labrum at its distal margin.\""}
def: "The region of the head capsule that is anterior to the frons and is attached to the labrum by the clypeo-labral conjunctiva" [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labrum
relationship: anterior_to AISM:0004020 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frons
relationship: continuous_with AISM:0004018 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeo-labral conjunctiva
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004020
name: frons {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Frons: frontal part of head capsule, delimited by ecdysial lines (frontal sutures); often triangular and bearing unpaired (median) ocellus.\""}
def: "The region of cuticle of the head capsule that is located posterior to the clypeus and delimited by the frontal suture." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: continuous_with AISM:0004029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frontal suture
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: posterior_to AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus

[Term]
id: AISM:0004021
name: postoccipital ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postoccipital ridge: strengthening ridge enclosing the foramen occipitale dorsally and laterally; also serving as muscle attachment area.\""}
def: "The ridge along the dorsal and lateral regions of the head capsule that is adjacent to the foramen occipitale." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: adjacent_to AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale

[Term]
id: AISM:0004022
name: circumocular ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Circumocular ridge: internal ridge enclosing compound eye.\""}
def: "The ridge of the head capsule surrounding the eye cuticle." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-02-19"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: AISM:0000078 AISM:0000088 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles eye cuticle
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004023
name: foramen occipitale {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Foramen occipitale (=foramen magnum): posterior opening of head capsule; divided by tentorial bridge into alaforamen and neuroforamen.\""}
def: "The foramen of the head capsule that connects with the neck membrane and is divided by the tentorial bridge into alaforamen and neuroforamen." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "occipital foramen" EXACT [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000197 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! arthropod foramen
relationship: adjacent_to AISM:0004024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorial bridge
relationship: continuous_with AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: continuous_with AISM:0000098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! neck membrane
relationship: has_part AISM:0004040 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! alaforamen
relationship: has_part AISM:0004041 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! neuroforamen

[Term]
id: AISM:0004024
name: tentorial bridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tentorial bridge (=corpotentorium): transverse element connecting posterior tentorial arms, often plate-like.\""}
def: "The apophysis of the tentorium originating from each posterior tentorial arm." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "corpotentorium" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tentorial bridge (=corpotentorium): transverse element connecting posterior tentorial arms, often plate-like.\""}
is_a: AISM:0000138 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular apophysis
relationship: continuous_with AISM:0004037 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! posterior tentorial arm
relationship: part_of AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0004025
name: vertex {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Vertex: posterodorsal part of head capsule, usually medially divided by ecdysial line (coronal suture).\""}
def: "The dorsal region of the head capsule that surrounds the coronal suture, and is connected laterally to the genae." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: AISM:0000078 AISM:0004030 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles coronal suture

[Term]
id: AISM:0004026
name: gena {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gena: lateral region of head capsule; not separated from vertex by a ridge or suture.\""}
def: "The lateral region of the head capsule, connected dorsally to the lateral regions of the vertex." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004027
name: subgena {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Subgena: narrow lateral region of head capsule, above external side of mandibular base, usually separated from gena by subgenal ridge.\""}
def: "The lateral region of the head capsule that connects dorsally to the ventral side of the gena and ventrally to the mandible." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0000043 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect mandible

[Term]
id: AISM:0004028
name: cuticular suture {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Suture: ecdysial suture, zone of weakness.\"", term:modified="2021-12-10"}
def: "The region of the cuticle of the head capsule that coincides with an ecdysial line." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule
relationship: RO:0002008 AISM:0004157 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coincident with ecdysial line

[Term]
id: AISM:0004029
name: frontal suture {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Frontal suture: paired ecdysial sutures enclosing frons; anterior parts of epicranial suture.\""}
def: "The cuticular suture that surrounds the frons and is connected to the coronal suture." [] {creation_date="2021-04-03", term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004028 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular suture
relationship: AISM:0000078 AISM:0004020 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles frons
relationship: continuous_with AISM:0004030 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coronal suture
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired

[Term]
id: AISM:0004030
name: coronal suture {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coronal suture: unpaired median ecdysial sutures dividing vertex; anteriorly continuous with frontal sutures.\""}
def: "The longitudinal cuticular suture that is on the vertex and is connected to the frontal suture." [] {creation_date="2021-04-03", term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004028 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular suture
relationship: AISM:0000079 AISM:0004025 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by vertex
relationship: continuous_with AISM:0004029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frontal suture
relationship: parallel_to BSPO:0000013 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior-posterior axis

[Term]
id: AISM:0004031
name: pleurostomal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n[Pleurostomal ridge: anterior section of the subgenal ridge above the mandibular base. (p. 14)]"}
def: "The ridge of the head capsule comprising the posterior region of the subgenal ridge." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge

[Term]
id: AISM:0004032
name: subgenal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Subgenal ridge: strengthening ridge separating gena from subgena.\""}
def: "The ridge of the head capsule that separates the gena and the subgena." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: adjacent_to AISM:0004026 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gena
relationship: adjacent_to AISM:0004027 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! subgena
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004033
name: hypostomal bridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Hypostomal bridge: partial closure of foramen occipitale, formed by ventromedially adjacent extensions of lateral head capsule.\"\n[posterior section of the subgenal ridge; p. 14]"}
def: "The lateral region of the head capsule that is adjacent to the foramen occipitale" [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004034
name: frontoclypeal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Frontoclypeal (strengthening) ridge (=frontoclypeal “suture”, epistomal “suture”): internal ridge separating clypeus from frons, between anterior tentorial pits.\""}
def: "The ridge of the head capsule that separates the clypeus and the frons." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: adjacent_to AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus
relationship: adjacent_to AISM:0004020 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frons
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004035
name: gula {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gula: sclerite partially closing foramen occipitale, formed by sclerotized region of ventral cervical membrane.\""}
def: "The sclerite on the ventral region of the head capsule that is limited laterally by the gular ridges, posteriorly by the foramen occipitale and anteriorly by the submentum." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: anterior_to AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale
relationship: continuous_with AISM:0004036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gular ridge
relationship: posterior_to AISM:0004005 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! submentum

[Term]
id: AISM:0004036
name: gular ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gular ridges: lateral internal ridges enclosing the gula.\""}
def: "Each ridge on the ventral region of the head capsule marking the sides of the gula." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge

[Term]
id: AISM:0004037
name: posterior tentorial arm {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Posterior tentorial arm: paired posterior element of tentorium; originates at posterior tentorial pit.\""}
def: "The apophysis of the tentorium that originates from each posterior tentorial pit." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000138 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular apophysis
relationship: continuous_with AISM:0000195 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! posterior tentorial pit
relationship: part_of AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0004038
name: anterior tentorial arm {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anterior tentorial arm: paired tentorial element anterior to tentorial bridge; originates at anterior tentorial pit.\""}
def: "The apophysis of the tentorium that is connected to an anterior tentorial pit." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000138 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular apophysis
relationship: continuous_with AISM:0000194 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior tentorial pit
relationship: part_of AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0004039
name: dorsal tentorial arm {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Dorsal tentorial arm: paired dorsal element of tentorium, originating at anterior arm or connecting area of anterior and posterior arm; often connected with head capsule by fibrillae.\""}
def: "The apophysis of the tentorium that is connected to an anterior tentorial arm." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000138 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular apophysis
relationship: continuous_with AISM:0004038 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior tentorial arm
relationship: part_of AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0004040
name: alaforamen {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter. \n\nhttps://doi.org/10.1515/9783110264043\n\n\"Alaforamen: part of foramen occipitale above tentorial bridge; passage of oesophagus and tracheal stems.\""}
def: "The arthropod foramen that is part of the foramen occipitale and is located above the tentorial bridge." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000197 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! arthropod foramen
relationship: dorsal_to AISM:0004024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorial bridge
relationship: part_of AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale

[Term]
id: AISM:0004041
name: neuroforamen {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Neuroforamen: part of foramen occipitale below tentorial bridge; passage of cervical connectives between suboesophageal complex and prothoracic ganglion.\""}
def: "The arthropod foramen that is part of the foramen occipitale and located below the tentorial bridge." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000197 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! arthropod foramen
relationship: part_of AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale
relationship: ventral_to AISM:0004024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorial bridge

[Term]
id: AISM:0004042
name: postgena {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postgena: posterior genal region anterior to postoccipital ridge.\""}
def: "The posterior region of the head capsule that is continuous with the posterior region of the gena and is anterior to the postoccipital ridge." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004043
name: postgenal bridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postgenal bridge: partial closure of foramen occipital formed by postgenal extensions.\""}
def: "The region of the head capsule that is continuous with the postgena and adjacent to the foramen occipitale." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004023 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! foramen occipitale
relationship: continuous_with AISM:0004042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postgena
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004044
name: circumantennal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"The antennal foramen is enclosed by a circumantennal ridge, which often bears a small articulatory process, the antennifer.\""}
def: "The ridge of the head capsule that encircles the antennal foramen." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: AISM:0000078 AISM:0000198 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles antennal foramen
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! head capsule

[Term]
id: AISM:0004045
name: postocciput {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postocciput: posteriormost head region.\""}
def: "The dorsolateral region of the head capsule that is posterior to the postoccipital ridge" [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", term:modified="2022-06-17"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: posterior_to AISM:0004021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! postoccipital ridge

[Term]
id: AISM:0004046
name: hypostoma {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Hypostoma: posterior part of subgena.\""}
def: "The region of the head capsule that comprises the posterior region of the subgena." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004047
name: hypostomal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Hypostomal ridge: posterior part of subgenal ridge.\""}
def: "The ridge composing the posterior region of the subgenal ridge." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge

[Term]
id: AISM:0004048
name: occipital ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Occipital ridge (=“occipital suture”): ridge on posterior head region; present in some groups, oblique and short or more or less parallel to postocciptal rigde (Orthoptera). No true segmental border.\""}
def: "The ridge that runs along the posterior region of the head capsule." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "occipital suture" EXACT [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
is_a: BSPO:0000077 ! proximal region

[Term]
id: AISM:0004049
name: postclypeus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postclypeus: sclerotized and pigmented proximal part of clypeus.\""}
def: "The region of cuticle comprising the posterior region of the clypeus." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004050
name: anteclypeus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anteclypeus: transparent distal part of clypeus.\""}
def: "The region of the cuticle comprising the anterior region of the clypeus." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004051
name: clypeolabrum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Clypeolabrum: area comprising the fused clypeus and labrum.\""}
def: "The region of the cuticle that is composed of the clypeus and the labrum." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_part AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labrum
relationship: has_part AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus

[Term]
id: AISM:0004052
name: insect compound eye {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Compound eye: paired main light sense organs; almost always composed of numerous ommatidia.\"", IAO:0000232="Modified 2023-01-09: specifying insect compound eye.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The sense organ of the insect head that is covered by the eye cuticle." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000018 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! compound eye
relationship: has_part AISM:0000088 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! eye cuticle
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head

[Term]
id: AISM:0004053
name: insect ocellus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ocellus: relatively simple median eye with single cornea lens and always lacking a crystalline cone: three are probably present in the groundplan of Insecta, but reductions occur in many groups.\"", IAO:0000232="Modified 2023-01-09: specifying insect ocellus.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The sense organ of the insect head that is covered by eye cuticle." [] {creation_date="2021-04-03", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000020 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sense organ
relationship: has_part AISM:0000088 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! eye cuticle
relationship: part_of AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect head

[Term]
id: AISM:0004054
name: laminatentoria {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"In some groups an accessory bridge is formed by medially fused internally directed processes, the laminatentoria. This feature is sometimes erroneously referred to as “perforated corpotentorium”.\""}
def: "Are apophyses of the tentorium originating at each anterior tentorial arm." [] {creation_date="2021-02-24", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000138 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular apophysis
relationship: continuous_with AISM:0004038 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anterior tentorial arm
relationship: part_of AISM:0000191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tentorium

[Term]
id: AISM:0004055
name: preabdomen {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Preabdomen (=pregenital segments): anterior abdominal segments (I–VII).\""}
def: "The region of cuticle of the insect abdomen that is posteriorly connected to the postabdomen." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen
relationship: posteriorly_connected_to AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004056
name: postabdomen {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postabdomen: posterior segments (VIII–XI) bearing genital appendages.\""}
def: "The region of cuticle of the insect abdomen that is anteriorly connected to the preabdomen." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: anteriorly_connected_to AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004057
name: abdominal tergite {AISM:0000171="Lawrence J, Ślipiński A (2013) 1 Australian beetles volume 1: morphology, classification and keys. CSIRO Publishing, 520 pp. \n\nhttps://www.publish.csiro.au/book/6466/\n\n\"major plate of the abdominal tergum\""}
def: "The sclerite of the insect abdomen that is dorsal and medial." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "abdominal tergum" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tergum: plate-like dorsal sclerite of abdominal segment.\""}
is_a: AISM:0000003 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect sclerite
relationship: part_of AISM:0000109 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect abdomen
relationship: part_of BSPO:0000079 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! dorsal region
relationship: part_of BSPO:0000083 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! medial region

[Term]
id: AISM:0004058
name: abdominal sternite
def: "The sclerite of the insect abdomen that is ventral and medial." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "abdominal sternum" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sternum: plate-like ventral sclerite of abdominal segment.\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen
relationship: part_of BSPO:0000083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! medial region
relationship: part_of BSPO:0000084 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ventral region

[Term]
id: AISM:0004059
name: pleural membrane {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pleural membrane: lateral unsclerotized part of abdominal segments, connecting tergum and sternum; usually bearing spiracles I–VIII.\""}
def: "The conjunctiva of the insect abdomen that surrounds the spiracles." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: AISM:0000078 AISM:0000135 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles insect spiracle
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004060
name: epiproct {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Epiproct: unpaired dorsal element (tergum) of segment XI.\""}
def: "The sclerite of the postabdomen that is attached to the posterior margin of the abdominal tergite X by the abdominal tergite X-epiproct conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
synonym: "proctiger" EXACT [] {AISM:0000171="Lawrence J, Ślipiński A (2013) 1 Australian beetles volume 1: morphology, classification and keys. CSIRO Publishing, 520 pp. \n\nhttps://www.publish.csiro.au/book/6466/\n\n[not defined]"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: continuous_with AISM:0004120 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! abdominal tergite X-epiproct conjunctiva
relationship: continuous_with AISM:0004197 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect anus
relationship: dorsal_to AISM:0004197 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect anus
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004061
name: paraproct {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Paraproct: paired lateral element of segment XI.\""}
def: "The paired sclerite of the insect abdomen that is attached to the lateral margin of the abdominal tergite X by the abdominal tergite X-paraproct conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0004197 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect anus
relationship: continuous_with AISM:0004167 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite X-paraproct conjunctiva
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004062
name: aedeagus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Aedeagus (penis is often used as a synonym): male copulatory organ.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticular evagination of the postabdomen that is distal and attached to the cuticle of parameres by the paramero-aedeagal conjunctiva and is connected to the endophallus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
synonym: "insect penis" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Penis: main element of the male copulatory apparatus.\""}
is_a: AISM:0000027 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular evagination
relationship: adjacent_to AISM:0004064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramere
relationship: continuous_with AISM:0004063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! endophallus
relationship: continuous_with AISM:0004200 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramero-aedeagal conjunctiva
relationship: distal_to AISM:0004064 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! paramere
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of aedeagus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004063
name: endophallus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Endophallus: membranous extrusible internal part of aedeagus.\""}
def: "The cuticular invagination of the postabdomen that is attached distally to the gonopore and basally to the aedeagus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000006 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular invagination
relationship: adjacent_to AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! aedeagus
relationship: adjacent_to AISM:0004075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonopore
relationship: distal_to AISM:0004075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonopore
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
relationship: proximal_to AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! aedeagus

[Term]
id: AISM:0004064
name: paramere {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Parameres: paired lateral parts of aedeagus.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the paired cuticular evagination of the postabdomen that is attached to the cuticle of phallobase by the phallobasal-parameral conjunctiva and to the cuticle of aedeagus by the paramero-aedeagal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000027 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular evagination
relationship: adjacent_to AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! aedeagus
relationship: continuous_with AISM:0004200 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramero-aedeagal conjunctiva
relationship: continuous_with AISM:0004201 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! phallobasal-parameral conjunctiva
relationship: distal_to AISM:0004065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! phallobase
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of paramere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004065
name: phallobase {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Phallobase (=basal piece): part of segment IX bearing copulatory organ.\""}
def: "The region of cuticle of the postabdomen that is attached to the abdominal sternite IX by the abdominal sternite IX-phallobase conjunctiva and to the paramere by the phallobasal-parameral conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
synonym: "basal piece" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Phallobase (=basal piece): part of segment IX bearing copulatory organ.\""}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramere
relationship: adjacent_to AISM:0004119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IX
relationship: continuous_with AISM:0004124 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IX-phallobase conjunctiva
relationship: continuous_with AISM:0004201 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! phallobasal-parameral conjunctiva
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004066
name: endophallite {AISM:0000171="Génier F (2019) Endophallites: a proposed neologism for naming the sclerotized elements of the insect endophallus (Arthropoda: Insecta). Annales de la Société entomologique de France (N.S.) 55: 482–484. \n\nhttps://doi.org/10.1080/00379271.2019.1685907 \n\n\"endophallite(s) refer to the sclerotized structures of the endophallus whether the structure be circular, flat, folded or spiniform.\""}
def: "The region of cuticle of the endophallus that is thicker." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_characteristic PATO:0000591 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! increased thickness
relationship: part_of AISM:0004063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! endophallus

[Term]
id: AISM:0004067
name: bursa copulatrix {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Bursa copulatrix: evagination of the vagina, receives the copulatory organ.\""}
def: "The region of the cuticle in the postabdomen that is attached to the genital chamber." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: continuous_with AISM:0004069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! genital chamber
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004068
name: gonocoxa VIII {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The paired sclerite of the postabdomen that is attached to the abdominal sternite VII by the abdominal sternite VII-gonocoxa conjunctiva and is articulated with abdominal tergite IX. It is attached at the base of gonostylus VIII and adjacent to the gonopore." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
synonym: "first coxopodite" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
synonym: "first gonocoxite" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
synonym: "first valvifer" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
is_a: AISM:0004301 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonocoxite
relationship: adjacent_to AISM:0004075 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! gonopore
relationship: continuous_with AISM:0004084 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII-gonocoxa VIII conjunctiva
property_value: IAO:0000589 "cuticle of gonocoxa VIII" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004069
name: genital chamber {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Genital chamber: cavity formed by an inflection of the body wall, receiving the common oviduct.\""}
def: "The region of cuticle that is connected to the oviduct, the bursa copulatrix and the gonocoxa VIII, and is adjacent to the gonopore." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonopore
relationship: continuous_with AISM:0004067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bursa copulatrix
relationship: continuous_with AISM:0004068 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonocoxa VIII
relationship: continuous_with AISM:0004083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect oviduct

[Term]
id: AISM:0004070
name: gonapophysis {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gonapophysis (=valves or valvulae 1–3): distal piece of ovipositor elements of female genital segments VIII and IX, inserted on coxopodites, usually elongated.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the abdominal sternite VIII that is part of the ovipositor." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect appendage
relationship: part_of AISM:0004077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ovipositor
relationship: part_of AISM:0004110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII
property_value: IAO:0000589 "cuticle of gonapophysis" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004071
name: sensillum placodeum {IAO:0000232="Modified 2023-01-11: moved under cuticular sensilla; added has part cuticular seta.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensillum placodeum: flat sensillum with strongly modified plate-like seta.\""}
def: "The seta that is flattened." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0004304 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular sensilla
relationship: has_characteristic PATO:0000407 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! flat
relationship: has_part AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular seta

[Term]
id: AISM:0004072
name: trichobothrium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Trichobothrium: very long and fine sensillum, vibroreceptor.\""}
def: "The seta that is elongated." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular seta
relationship: has_characteristic PATO:0001154 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! elongated

[Term]
id: AISM:0004073
name: paraphyses {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Paraphyses (=titillators): paired appendages of aedeagus.\""}
def: "The proximal apodemes of the aedeagus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "titillators" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Paraphyses (=titillators): paired appendages of aedeagus.\""}
is_a: AISM:0000188 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! apodeme
relationship: proximal_to AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! aedeagus

[Term]
id: AISM:0004074
name: ductus ejaculatorius {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ductus ejaculatorius: unpaired ectodermal duct connecting vasa deferentia (i.e. vesiculae seminales) and aedeagus.\""}
def: "The region of the cuticle thar is proximally attached to the gonopore." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonopore
relationship: proximal_to AISM:0004075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonopore

[Term]
id: AISM:0004075
name: gonopore {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gonopore: external opening of the common oviduct.\"", creation_date="2021-03-05"}
def: "The orifice in the postabdomen that marks the opening of the reproductive system." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: UBERON:0000161 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! orifice
relationship: AISM:0000079 AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by postabdomen

[Term]
id: AISM:0004076
name: gonostylus VIII {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Gonostyli: appendages of gonocoxae (usually only on coxopodite IX)\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle of the postabdomen that is paired and connected to the anterior region of the gonocoxa VIII." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of gonostylus VIII" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004077
name: ovipositor {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ovipositor: paired postabdominal apparatus (segments VIII and IX) primarily used for depositing eggs.\""}
def: "The region of cuticle of the postabdomen that is distal to the genital chamber." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: distal_to AISM:0004069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! genital chamber
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004078
name: spermatheca {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Spermatheca (=receptaculum seminis): unpaired or paired evagination of female genital tract; storage of sperm; connected by spermathecal duct (=ductus receptaculi) with vagina or bursa copulatrix.\""}
def: "The region of the cuticle that is part of the oviduct and connected to the bursa copulatrix." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: continuous_with AISM:0004067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bursa copulatrix
relationship: part_of AISM:0004083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect oviduct

[Term]
id: AISM:0004079
name: spermathecal gland {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Spermathecal gland: provides nourishment for spermatozoa stored in spermatheca.\""}
def: "The region of the cuticle that is part of the oviduct and attached to the spermatheca." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: continuous_with AISM:0004078 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! spermatheca
relationship: part_of AISM:0004083 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect oviduct

[Term]
id: AISM:0004080
name: precoxal sulcus
def: "The sulcus that coincides with the precoxal ridge." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
synonym: "precoxal suture" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Precoxal suture: suture separating katepisternum and preepisternum.\""}
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular sulcus
relationship: RO:0002008 AISM:0004162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coincident with precoxal ridge

[Term]
id: AISM:0004081
name: pleural wing process {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Fulcrum (=pleural wing process): anterodorsal apex of the pleural ridge.\""}
def: "The cuticular protrusion of the pleuron that is connected lateraly to the notum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "fulcrum" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Fulcrum (=pleural wing process): anterodorsal apex of the pleural ridge.\""}
is_a: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular protrusion
relationship: AISM:0000011 AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! lateral_to notum
relationship: part_of AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0004082
name: metanoto-abdominal tergite I conjunctiva
def: "The conjunctiva between the insect thorax and the insect abdomen that connects the posterior margin of the metanotum to the anterior margin of the abdominal tergite I." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite I
relationship: continuous_with AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum

[Term]
id: AISM:0004083
name: insect oviduct {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Oviduct: female genital duct; originating as paired structures from ovarioles, uniting as common (median) oviduct.\""}
def: "The region of cuticle that is continuous with the genital chamber." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
is_a: UBERON:0000993 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! oviduct
relationship: continuous_with AISM:0004069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! genital chamber

[Term]
id: AISM:0004084
name: abdominal sternite VIII-gonocoxa VIII conjunctiva
def: "The conjunctiva of the insect abdomen that joins the abdominal sternite VIII and the gonocoxa VIII." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-01-09: correct sternite VII to VIII.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004068 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gonocoxa VIII
relationship: continuous_with AISM:0004110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004085
name: abdominal tergite II
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite I by the abdominal tergite I-abdominal tergite II conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004086 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite I-abdominal tergite II conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004086
name: abdominal tergite I-abdominal tergite II conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite I and the abdominal tergite II." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite I
relationship: continuous_with AISM:0004085 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite II
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004087
name: abdominal tergite III
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite II by the abdominal tergite II-abdominal tergite III conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004088 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite II-abdominal tergite III conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004088
name: abdominal tergite II-abdominal tergite III conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite II and the abdominal tergite III." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004085 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite II
relationship: continuous_with AISM:0004087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite III
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004089
name: abdominal tergite III-abdominal tergite IV conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite III and the abdominal tergite IV." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite III
relationship: continuous_with AISM:0004090 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IV
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004090
name: abdominal tergite IV
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite III by the abdominal tergite III-abdominal tergite IV conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004089 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite III-abdominal tergite IV conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004091
name: abdominal tergite V
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite IV by the abdominal tergite IV-abdominal tergite V conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004092 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IV-abdominal tergite V conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004092
name: abdominal tergite IV-abdominal tergite V conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite IV and the abdominal tergite V." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004090 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IV
relationship: continuous_with AISM:0004091 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite V
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004093
name: abdominal tergite VI
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite V by the abdominal tergite V-abdominal tergite VI conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004094 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite V-abdominal tergite VI conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004094
name: abdominal tergite V-abdominal tergite VI conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite V and the abdominal tergite VI." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004091 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite V
relationship: continuous_with AISM:0004093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VI
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004095
name: abdominal tergite VII
def: "Is the abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal tergite VI by the abdominal tergite VI-abdominal tergite VII conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004096 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VI-abdominal tergite VII conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004096
name: abdominal tergite VI-abdominal tergite VII conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite VI and the abdominal tergite VII." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VI
relationship: continuous_with AISM:0004095 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VII
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004097
name: abdominal tergite VIII
def: "Is the abdominal tergite of the postabdomen that is attached to the posterior margin of the abdominal tergite VII by the abdominal tergite VII-abdominal tergite VIII conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VII-abdominal tergite VIII conjunctiva
relationship: part_of AISM:0000523 ! dorsal postabdomen

[Term]
id: AISM:0004098
name: abdominal tergite VII-abdominal tergite VIII conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite VII and the abdominal tergite VIII." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004095 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VII
relationship: continuous_with AISM:0004097 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VIII
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004099
name: laterotergite {AISM:0000171="Lawrence J, Ślipiński A (2013) 1 Australian beetles volume 1: morphology, classification and keys. CSIRO Publishing, 520 pp. \n\nhttps://www.publish.csiro.au/book/6466/\n\nadditional pair of sclerites flanking each tergite"}
name: laterotergite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Laterotergite: separate lateral portion of abdominal tergum (only few groups).\""}
def: "The sclerite of the insect thorax or the insect abdomen that is on the lateral region of the notum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "paranota" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Paranota (=laterotergites): dorsolateral tergal duplicatures.\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004100
name: abdominal sternite I
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the metasternum by the metasterno-abdominal sternite I conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metasterno-abdominal sternite I conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004101
name: metapleuro-metasternal conjunctiva
def: "The conjunctiva of the metathorax that joins the metapleura and the metasternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuron
relationship: continuous_with AISM:0004232 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metasternum
relationship: part_of AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax

[Term]
id: AISM:0004102
name: metasterno-abdominal sternite I conjunctiva
def: "The conjunctiva between the insect thorax and the insect abdomen that connects the posterior margin of the metasterum to the anterior margin of the abdominal sternite I." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004100 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite I
relationship: continuous_with AISM:0004101 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuro-metasternal conjunctiva

[Term]
id: AISM:0004103
name: abdominal sternite I-abdominal sternite II conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite I and the abdominal sternite II." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004100 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite I
relationship: continuous_with AISM:0004104 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite II
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004104
name: abdominal sternite II
def: "The abdominal tergite of the preabdomen that is attached to the posterior margin of the abdominal sternite I by the abdominal sternite I-abdominal sternite II conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004103 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite I-abdominal sternite II conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004105
name: abdominal sternite III
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the abdominal sternite II by the abdominal sternite II-abdominal sternite III conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004111 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite II-abdominal sternite III conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004106
name: abdominal sternite IV
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the abdominal sternite III by the abdominal sternite III-abdominal sternite IV conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004112 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite III-abdominal sternite IV conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004107
name: abdominal sternite V
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the abdominal sternite IV by the abdominal sternite IV-abdominal sternite V conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004113 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IV-abdominal sternite V conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004108
name: abdominal sternite VI
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the abdominal sternite V by the abdominal sternite V-abdominal sternite VI conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004114 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite V-abdominal sternite VI conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004109
name: abdominal sternite VII
def: "The abdominal sternite of the preabdomen that is attached to the posterior margin of the abdominal sternite VI by the abdominal sternite VI-abdominal sternite VII conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004115 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VI-abdominal sternite VII conjunctiva
relationship: part_of AISM:0004055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! preabdomen

[Term]
id: AISM:0004110
name: abdominal sternite VIII
def: "The abdominal sternite of the postabdomen that is attached to the posterior margin of the abdominal sternite VII by the abdominal sternite VII-abdominal sternite VIII conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
relationship: posteriorly_connected_to AISM:0004123 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII-abdominal sternite IX conjunctiva

[Term]
id: AISM:0004111
name: abdominal sternite II-abdominal sternite III conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite II and the abdominal sternite III." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004104 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite II
relationship: continuous_with AISM:0004105 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite III
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004112
name: abdominal sternite III-abdominal sternite IV conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite III and the abdominal sternite IV." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004105 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite III
relationship: continuous_with AISM:0004106 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IV
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004113
name: abdominal sternite IV-abdominal sternite V conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite IV and the abdominal sternite V." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004106 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IV
relationship: continuous_with AISM:0004107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite V
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004114
name: abdominal sternite V-abdominal sternite VI conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite V and the abdominal sternite VI." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite V
relationship: continuous_with AISM:0004108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VI
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004115
name: abdominal sternite VI-abdominal sternite VII conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite VI and the abdominal sternite VII." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VI
relationship: continuous_with AISM:0004109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VII
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004116
name: abdominal sternite VII-abdominal sternite VIII conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite VII and the abdominal sternite VIII." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VII
relationship: continuous_with AISM:0004110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004117
name: abdominal tergite IX
def: "Is the abdominal tergite of the postabdomen that is attached to the posterior margin of the abdominal tergite VIII by the abdominal tergite VIII-abdominal tergite IX conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004121 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VIII-abdominal tergite IX conjunctiva
relationship: part_of AISM:0000523 ! dorsal postabdomen

[Term]
id: AISM:0004118
name: abdominal tergite X
def: "Is the abdominal tergite of the postabdomen that is attached to the posterior margin of the abdominal tergite IX by the abdominal tergite IX-abdominal tergite X conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004057 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite
relationship: anteriorly_connected_to AISM:0004122 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IX-abdominal tergite X conjunctiva
relationship: part_of AISM:0000523 ! dorsal postabdomen

[Term]
id: AISM:0004119
name: abdominal sternite IX
def: "The abdominal sternite of the postabdomen that is attached to the posterior margin of the abdominal sternite VIII by the abdominal sternite VIII-abdominal sternite IX conjunctiva." [] {creation_date="2021-03-14", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004058 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite
relationship: anteriorly_connected_to AISM:0004116 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VII-abdominal sternite VIII conjunctiva
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004120
name: abdominal tergite X-epiproct conjunctiva
def: "The conjunctiva of the postabdomen that joins the abdominal tergite X and the epiproct." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004060 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epiproct
relationship: continuous_with AISM:0004118 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite X
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004121
name: abdominal tergite VIII-abdominal tergite IX conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite VIII and the abdominal tergite IX." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004097 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite VIII
relationship: continuous_with AISM:0004117 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IX
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004122
name: abdominal tergite IX-abdominal tergite X conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal tergite IX and the abdominal tergite X." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004117 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite IX
relationship: continuous_with AISM:0004118 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite X
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004123
name: abdominal sternite VIII-abdominal sternite IX conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite VIII and the abdominal sternite IX." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite VIII
relationship: continuous_with AISM:0004119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IX
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004124
name: abdominal sternite IX-phallobase conjunctiva
def: "The conjunctiva of the insect abdomen that connects the abdominal sternite IX and the abdominal sternite X." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! phallobase
relationship: continuous_with AISM:0004119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal sternite IX
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect abdomen

[Term]
id: AISM:0004125
name: prothorax {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prothorax: 1st thoracic segment, always completely wingless in extant hexapods.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle of the insect thorax that is anteriorly connected to the head by the neck membrane, posteriorly connected to the mesothorax by the prothorax-mesothorax conjunctiva, and contains the pronotum, the propeluron, the prosternum and one pair of legs." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: anteriorly_connected_to AISM:0000098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! neck membrane
relationship: has_part AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
relationship: has_part AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum
relationship: has_part AISM:0000060 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! labial palpomere
relationship: has_part AISM:0000061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prosternum
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax
relationship: posteriorly_connected_to AISM:0000046 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothoracic-mesothoracic conjunctiva
property_value: IAO:0000589 "cuticle of prothorax" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004126
name: mesothorax {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Mesothorax: 2nd thoracic segment, anterior segment of pterothorax; bearing forewings (groundplan of Pterygota).\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle of the pterothorax that bears mid legs and fore wings." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_part AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
relationship: has_part AISM:0000037 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore wing
relationship: part_of AISM:0004166 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pterothorax
property_value: IAO:0000589 "cuticle of mesothorax" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004127
name: metathorax {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Metathorax: 3rd thoracic segment, posterior segment of pterothorax; bearing hindwings (groundplan of Pterygota).\"", term:modified="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle of the pterothorax that bears the hind legs and the hind wings." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_part AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
relationship: has_part AISM:0000038 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind wing
relationship: part_of AISM:0004166 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pterothorax
property_value: IAO:0000589 "cuticle of metathorax" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004128
name: notum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Notum: larger anterior part of tergum, composed of presutum, scutum and scutellum.\""}
def: "The dorsal region of the cuticle of the insect thorax that is attached to the dorsal margin of the pleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "tergum" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tergum: dorsal wall of a thoracic (or abdominal) segment.\""}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004129
name: pleuron {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pleuron: lateral wall of thoracic segments, almost always divided by pleural ridge into anterior episternum and posterior epimeron.\""}
def: "The region of cuticle on the lateral region of the insect thorax that is attached to the notum and the sternum and is attached to the coxae by skeletal muscle tissue and the basal coxal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
is_a: UBERON:0000061 ! anatomical structure
relationship: adjacent_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: adjacent_to AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum
relationship: continuous_with AISM:0000173 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! basal coxal conjunctiva

[Term]
id: AISM:0004130
name: sternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sternum: ventral wall of thoracic (or abdominal) segment, usually divided into presternum, basisternum, furcasternum and spinasternum in unspecialized hexapods; largely or completely invaginated in Holometabola (cryptosterny).\""}
def: "The ventral region of the cuticle of the insect thorax that is attached to the ventral margin of the pleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004131
name: pleurite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pleurite: sclerotized element of pleuron.\""}
def: "The sclerite that is part of the pleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0004132
name: pleural ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pleural ridge: internal ridge, corresponding to externally visible pleural “suture”; separates episternum and epimeron; anterodorsally forming the pleural wing process and posteroventrally the pleuro-coxal joint.\""}
def: "The ridge between the epimeron and the episternum in either the mesothorax or the metathorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: continuous_with AISM:0004133 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! episternum
relationship: continuous_with AISM:0004134 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epimeron

[Term]
id: AISM:0004133
name: episternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Episternum: part of pleuron anterior to pleural ridge.\""}
def: "The sclerite of the insect thorax that is part of the pleuron and anterior to the pleural ridge and attached to the anterior margin of the epimeron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: anterior_to AISM:0004132 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleural ridge
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0004134
name: epimeron {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Epimeron: part of pleuron posterior to pleural ridge.\""}
def: "The sclerite of the insect thorax that is part of the pleuron and posterior to the pleural ridge and attached to the posterior margin of the episternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron
relationship: posterior_to AISM:0004132 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleural ridge

[Term]
id: AISM:0004135
name: trochantin {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Trochantin: small triangular or sickle-shaped ventral pleural sclerite; anteriorly articulating with coxa (trochantino-coxal joint).\""}
def: "The sclerite that is located on the ventro-lateral region of the insect thorax and is attached to a coxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: AISM:0000079 AISM:0000173 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by basal coxal conjunctiva

[Term]
id: AISM:0004136
name: presternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Presternum: anteriormost part of sternum.\""}
def: "The part of the sternum that is attached to the anterior margin of the basisternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0004137
name: basisternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Basisternum: main part of sternum, between presternum and furcasternum.\""}
def: "The part of the sternum that is attached to the posterior margin of the presternum and to the anterior margin of the furcasternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0004138
name: furcasternum {x_1.1:contributor="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Furcasternum (=sternellum): sternal element posterior to basisternum, area of origin of furca.\""}
def: "The part of the sternum that is attached to the posterior margin of the basisternum and to the anterior margin of the spinasternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
synonym: "sternellum" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Furcasternum (=sternellum): sternal element posterior to basisternum, area of origin of furca.\""}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0004139
name: spinasternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Spinasternum: small posterior sternal element, determining the posterior segmental border; area of origin of spina.\""}
def: "The part of the sternum that is attached to the posterior margin of the furcasternum and to the anterior margin of the poststernite." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0004140
name: poststernite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Poststernite: posteriormost sternal element.\""}
def: "The part of the sternum that is attached to the posterior margin of the spinasternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum

[Term]
id: AISM:0004141
name: cervical sclerite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Cervical sclerite: articulatory sclerite embedded in the cervical membrane.\""}
def: "The sclerite that is surrounded by the neck membrane." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: AISM:0000079 AISM:0000098 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by neck membrane

[Term]
id: AISM:0004142
name: propleuron
def: "The region of the cuticle on the lateral region of the prothorax that is attached to the pronotum and the prosternum, and is attached to the procoxa by the procoxal muscle and the basal procoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron
relationship: adjacent_to AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum
relationship: adjacent_to AISM:0000061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prosternum
relationship: continuous_with AISM:0000106 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! basal procoxal conjunctiva
relationship: continuous_with AISM:0000145 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! procoxal muscle

[Term]
id: AISM:0004143
name: postnotum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postnotum: smaller posterior part of tergum, forming internal intersegmental phragma; attachment area for dorsal indirect flight muscles.\""}
def: "The sclerite of the notum that is attached to the posterior margin of the scutellum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004144
name: prescutum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prescutum: anteriormost part of notum.\""}
def: "The sclerite of the notum that is attached to the anterior margin of the scutum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004145
name: scutum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Scutum: large anterior part of notum.\""}
def: "The sclerite of the notum that is attached to the posterior margin of the prescutum and to the anterior margin of the scutellum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004146
name: scutellum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Scutellum: smaller posterior part of notum.\""}
def: "The sclerite of the notum that is attached to the posterior margin of the scutum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004147
name: alinotum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Alinotum: part of the notum connected with the wing base.\""}
def: "The sclerite that is on the lateral region of the notum and is adjacent to the wing." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000033 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing

[Term]
id: AISM:0004148
name: prealar sclerite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prealare (=prealar sclerite): small attachment area of short direct flight muscles.\""}
def: "The sclerite of the pterothorax that is attached to some muscle." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "prealare" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prealare (=prealar sclerite): small attachment area of short direct flight muscles.\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: continuous_with UBERON:0014895 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! somatic muscle
relationship: part_of AISM:0004166 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pterothorax

[Term]
id: AISM:0004149
name: prealar bridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Prealar bridge: prescutal process, bent downwards and linked with episternum.\""}
def: "The region of cuticle of the dorso-lateral region of the pterothorax that is surrounded by the noto-pleural conjunctiva and articulated with the episternum." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004133 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! episternum
relationship: continuous_with AISM:0004222 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! noto-pleural conjunctiva

[Term]
id: AISM:0004150
name: postalar bridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postalar bridge: lateral postnotal margin bent downwards and connected with the epimeron.\""}
def: "The region of cuticle of the dorso-lateral region of the pterothorax that is surrounded by the noto-pleural conjunctiva and articulated with the epimeron." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: adjacent_to AISM:0004134 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epimeron
relationship: continuous_with AISM:0004222 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! noto-pleural conjunctiva

[Term]
id: AISM:0004151
name: epipleurite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Epipleurites: basalare and subalare.\""}
def: "The sclerite of the insect thorax that is surrounded by the noto-pleural conjunctiva and is adjacent to the wing." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: adjacent_to AISM:0000033 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing
relationship: AISM:0000079 AISM:0004080 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by precoxal sulcus
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0004152
name: basalare {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Basalare: sclerite associated with wing base, more or less distinctly separated from anepisternum; usually with internal muscle disc; attachment site of direct flight muscles.\""}
def: "The epipleurite that is adjacent to the anepisternum, is attached to the pleuron via muscle, is surrounded by the noto-pleural conjunctiva, and is anterior to the first axillary sclerite." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004151 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epipleurite
is_a: UBERON:0000061 ! anatomical structure
relationship: adjacent_to AISM:0004154 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anepisternum
relationship: AISM:0000079 AISM:0004222 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by noto-pleural conjunctiva
relationship: anterior_to AISM:0000022 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! first axillary sclerite

[Term]
id: AISM:0004153
name: subalare {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Subalare: sclerite associated with wing base, usually embedded in membrane between tergum and pleuron; attachment site of direct flight muscles.\""}
def: "The epipleurite that is adjacent to the notum, is attached to the coxa via muscle, is surrounded by the noto-pleural conjunctiva, and is posterior to the first axillary sclerite." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004151 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epipleurite
is_a: UBERON:0000061 ! anatomical structure
relationship: adjacent_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: AISM:0000079 AISM:0004222 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by noto-pleural conjunctiva
relationship: posterior_to AISM:0000022 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! first axillary sclerite

[Term]
id: AISM:0004154
name: anepisternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anepisternum: dorsal part of episternum, ventrally delimited by anapleural suture.\""}
def: "The dorsal region of the episternum that is dorsal to the anapleural sulcus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: dorsal_to AISM:0004156 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anapleural sulcus
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired

[Term]
id: AISM:0004155
name: preepisternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Preepisternum: anterior part of ventral episternal region; delimited from katepisternum by precoxal suture; largest part of ventrite in Holometabola.\""}
def: "The region of cuticle on the antero-ventral region of the episternum that is anterior to the anapleural sulcus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: anterior_to AISM:0004156 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anapleural sulcus

[Term]
id: AISM:0004156
name: anapleural sulcus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anapleural suture (=paracoxal suture): suture horizontally delimiting dorsal and ventral parts of episternum and (partially) epimeron; sometimes anteriorly widened and membranous (=anapleural cleft).\""}
def: "The sulcus of the pleuron delimiting the dorsal region of the preepisternum and the ventral region of the anepisternum." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "anapleural cleft" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anapleural suture (=paracoxal suture): suture horizontally delimiting dorsal and ventral parts of episternum and (partially) epimeron; sometimes anteriorly widened and membranous (=anapleural cleft).\""}
synonym: "paracoxal suture" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anapleural suture (=paracoxal suture): suture horizontally delimiting dorsal and ventral parts of episternum and (partially) epimeron; sometimes anteriorly widened and membranous (=anapleural cleft).\""}
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular sulcus
relationship: part_of AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0004157
name: ecdysial line
def: "The anatomical line of weakness of the cuticle that allows molting and coincides with a suture." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "molting line" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Molting lines (frontal and coronal sutures [=epicranial lines or sutures])\""}
is_a: CARO:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anatomical line
relationship: RO:0002008 AISM:0004028 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coincident with cuticular suture

[Term]
id: AISM:0004158
name: katepisternum {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Katepisternum: posterior part of ventral episternal region; separated from preepisternum by precoxal suture.\""}
def: "The region of cuticle on the postero-ventral region of the episternum that is posterior to the anapleural sulcus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: posterior_to AISM:0004156 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anapleural sulcus

[Term]
id: AISM:0004159
name: anepimeron {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anepimeron: dorsal part of epimeron (present as separate element in some groups).\""}
def: "The region of the cuticle on the dorsal region of the epimeron." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired

[Term]
id: AISM:0004160
name: katepimeron {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Katepimeron: ventral part of epimeron (present as separate element in some groups).\""}
def: "The region of cuticle on the ventral region of the epimeron." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle

[Term]
id: AISM:0004161
name: axillary sclerite {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Axillary sclerites (=axillaria, pteralia): small sclerites of wing base (usually 3); articulating with notal wing processes.\""}
def: "The sclerite that is surrounded by the basal wing conjunctiva." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "pteralia" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pteralia: small sclerites of wing base (axillary sclerites + plates).\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: AISM:0000079 AISM:0004203 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircled by basal wing conjunctiva
relationship: part_of AISM:0004258 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! axillary region of the insect wing

[Term]
id: AISM:0004162
name: precoxal ridge {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Precoxal ridge: mediolaterally directed ridge in front of coxa, corresponding with externally visible precoxal suture.\""}
def: "The ridge that is anterior to a coxa, demarcated by the anapleural sulcus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000158 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular ridge
relationship: anterior_to AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: continuous_with AISM:0004156 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! anapleural sulcus

[Term]
id: AISM:0004163
name: spina {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Spina: smaller posterior endoskeletal element of thoracic segments, unpaired, arising on spinasternum.\""}
def: "The sclerite attached to the spinasternum." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: continuous_with AISM:0004139 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! spinasternum

[Term]
id: AISM:0004165
name: cercus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Cerci: tactile appendages of segment XI, primarily multisegmented and tactile bearing setae.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The bilaterally paired region of the cuticle of the postabdomen located between the epiproct and the paraproct" [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
intersection_of: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! insect region of cuticle
intersection_of: adjacent_to AISM:0004060 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! epiproct
intersection_of: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! bilaterally paired
intersection_of: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-08-01"} ! postabdomen
relationship: adjacent_to AISM:0004060 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epiproct
relationship: adjacent_to AISM:0004061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraproct
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of cercus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004166
name: pterothorax {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pterothorax: 2nd and 3nd thoracic segments; bearing wings (groundplan of Pterygota), meso- and metathorax.\""}
def: "The region of cuticle of the insect thorax that contains the mesothorax and the metathorax and bears the mid legs, the hind legs and the wings." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-05"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_part AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax
relationship: has_part AISM:0004127 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metathorax
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0004167
name: abdominal tergite X-paraproct conjunctiva
def: "The conjunctiva of the postabdomen that joins the abdominal tergite X and each paraproct." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraproct
relationship: continuous_with AISM:0004118 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite X
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004168
name: trochanter {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Trochanter: 2nd element of leg, usually small and triangular.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a leg attached to the distal margin of the coxa by the coxal-trochanteral conjunctiva and to the proximal margin of the femur by the trochantero-femoral conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! appendage segment
relationship: AISM:0000078 AISM:0004174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles trochantero-femoral conjunctiva
relationship: AISM:0000079 AISM:0004170 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by coxal-trochanteral conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of trochanter" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004169
name: tarsus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Tarsus: 5th part of leg; undivided in entognathous orders, composed of 3–5 tarsomeres in most groups of Insecta.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the leg that is composed of tarsomeres connected to each other by intertarsomeral conjunctiva. The first tarsomere is connected to the distal margin of the tibia by the tibio-tarsal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! appendage segment
relationship: AISM:0000079 AISM:0004182 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by tibio-tarsal conjunctiva
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: has_part AISM:0000074 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsomere
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg
property_value: IAO:0000589 "cuticle of tarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004170
name: coxal-trochanteral conjunctiva
def: "The conjunctiva of the leg joining the distal margin of a coxa and the proximal margin of a femur." [] {creation_date="2021-03-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000102 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles trochanter
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0004171
name: protrochanter {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a fore leg attached to the distal margin of the procoxa by the procoxal-protrochanteral conjunctiva and to the proximal margin of the profemur by the protrochantero-profemoral conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter
relationship: AISM:0000078 AISM:0004175 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles protrochantero-profemoral conjunctiva
relationship: AISM:0000079 AISM:0000123 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by procoxal-protrochanteral conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of protrochanter" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004172
name: mesotrochanter {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a mid leg attached to the distal margin of the mesocoxa by the mesocoxal-mesotrochanteral conjunctiva and to the proximal margin of the mesofemur by the mesotrochantero-mesofemoral conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter
relationship: AISM:0000078 AISM:0004176 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles mesotrochantero-mesofemoral conjunctiva
relationship: AISM:0000079 AISM:0000124 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesocoxal-mesotrochanteral conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of mesotrochanter" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004173
name: metatrochanter {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of a hind leg attached to the distal margin of the metacoxa by the metacoxal-metatrochanteral conjunctiva and to the proximal margin of the metafemur by the metatrochantero-metafemoral conjunctiva." [] {term:modified="2021-12-08", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter
relationship: AISM:0000078 AISM:0004177 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles metatrochantero-metafemoral conjunctiva
relationship: AISM:0000079 AISM:0000125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metacoxal-metatrochanteral conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metatrochanter" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004174
name: trochantero-femoral conjunctiva
def: "The conjunctiva that encircles the femur by joining the distal margin of the trochanter and the proximal margin of the femur." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-18"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles femur
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0004175
name: protrochantero-profemoral conjunctiva
def: "The conjunctiva that encircles the profemur by joining the distal margin of the protrochanter and the proximal margin of the profemur." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochantero-femoral conjunctiva
relationship: AISM:0000078 AISM:0000070 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles profemur
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg

[Term]
id: AISM:0004176
name: mesotrochantero-mesofemoral conjunctiva
def: "The conjunctiva that encircles the mesofemur by joining the distal margin of the mesotrochanter and the proximal margin of the mesofemur." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochantero-femoral conjunctiva
relationship: AISM:0000078 AISM:0000071 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles mesofemur
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg

[Term]
id: AISM:0004177
name: metatrochantero-metafemoral conjunctiva
def: "The conjunctiva that encircles the metafemur by joining the distal margin of the metatrochanter and the proximal margin of the metafemur." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochantero-femoral conjunctiva
relationship: AISM:0000078 AISM:0000072 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles metafemur
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg

[Term]
id: AISM:0004178
name: femoro-tibial conjunctiva
def: "The conjunctiva that encircles the tibia by joining the distal margin of the femur and the proximal margin of the tibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles tibia
relationship: AISM:0000079 AISM:0000076 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by femur
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0004179
name: profemoro-protibial conjunctiva
def: "The conjunctiva that encircles the protibia by joining the distal margin of the profemur and the proximal margin of the protibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004178 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femoro-tibial conjunctiva
relationship: AISM:0000078 AISM:0000067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles protibia
relationship: AISM:0000079 AISM:0000070 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by profemur
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg

[Term]
id: AISM:0004180
name: mesofemoro-mesotibial conjunctiva
def: "The conjunctiva that encircles the mesotibia by joining the distal margin of the mesofemur and the proximal margin of the mesotibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004178 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femoro-tibial conjunctiva
relationship: AISM:0000078 AISM:0000068 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles mesotibia
relationship: AISM:0000079 AISM:0000071 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesofemur
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg

[Term]
id: AISM:0004181
name: metafemoro-metatibial conjunctiva
def: "The conjunctiva that encircles the metatibia by joining the distal margin of the metafemur and the proximal margin of the metatibia." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004178 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! femoro-tibial conjunctiva
relationship: AISM:0000078 AISM:0000069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles metatibia
relationship: AISM:0000079 AISM:0000072 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metafemur
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg

[Term]
id: AISM:0004182
name: tibio-tarsal conjunctiva
def: "The conjunctiva that encircles the tarsus by joining the distal margin of the tibia and the proximal margin of the tarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles tarsus
relationship: AISM:0000079 AISM:0000075 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by tibia
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0004183
name: protibio-protarsal conjunctiva
def: "The conjunctiva that encircles the protarsus by joining the distal margin of the protibia and the proximal margin of the protarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004182 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibio-tarsal conjunctiva
relationship: AISM:0000078 AISM:0004190 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles protarsus
relationship: AISM:0000079 AISM:0000067 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by protibia
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg

[Term]
id: AISM:0004184
name: mesotibio-mesotarsal conjunctiva
def: "The conjunctiva that encircles the mesotarsus by joining the distal margin of the mesotibia and the proximal margin of the mesotarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004182 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibio-tarsal conjunctiva

[Term]
id: AISM:0004185
name: metatibio-metatarsal conjunctiva
def: "The conjunctiva that encircles the metatarsus by joining the distal margin of the metatibia and the proximal margin of the metatarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004182 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tibio-tarsal conjunctiva
relationship: AISM:0000078 AISM:0004188 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles metatarsus
relationship: AISM:0000079 AISM:0000069 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metatibia
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg

[Term]
id: AISM:0004186
name: mesopleuron
def: "The region of the cuticle on the lateral region of the mesothorax that is attached to the mesonotum and the mesosternum, and is attached to the mesocoxa by the mesocoxal muscle and the basal mesocoxal conjunctiva." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron
relationship: adjacent_to AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: adjacent_to AISM:0000121 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesosternum
relationship: continuous_with AISM:0000085 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesocoxal muscle
relationship: continuous_with AISM:0000103 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! basal mesocoxal conjunctiva

[Term]
id: AISM:0004187
name: tarso-pretarsal conjunctiva
def: "The conjunctiva that encircles the pretarsus by joining the distal margin of the distalmost tarsomere and the proximal margin of the pretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ring conjunctiva
relationship: AISM:0000078 AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles pretarsus
relationship: AISM:0000079 AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by tarsus
relationship: part_of AISM:0000031 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect leg

[Term]
id: AISM:0004188
name: metatarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the leg that is composed of metatarsomeres connected to each other by intertarsomeral conjunctiva. The first metatarsomere is connected to the distal margin of the metatibia by the metatibio-metatarsal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsus
relationship: AISM:0000079 AISM:0004185 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metatibio-metatarsal conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metatarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004189
name: mesotarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the mid leg that is composed of mesotarsomeres connected to each other by intertarsomeral conjunctiva. The first mesotarsomere is connected to the distal margin of the mesotibia by the mesotibio-mesotarsal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsus
relationship: AISM:0000079 AISM:0004184 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesotibio-mesotarsal conjunctiva
property_value: IAO:0000589 "cuticle of mesotarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004190
name: protarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the segment of the leg that is composed of protarsomeres connected to each other by intertarsomeral conjunctiva. The first protarsomere is connected to the distal margin of the protibia by the protibio-protarsal conjunctiva." [] {term:modified="2021-12-08", IAO:0000232="Modified 2023-04-13: removed distally adjacent elements to avoid problems with their absence during presence/absence reasoning.\njgiron https://orcid.org/0000-0002-0851-6883", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarsus
relationship: AISM:0000079 AISM:0004183 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by protibio-protarsal conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of protarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004191
name: protarso-propretarsal conjunctiva
def: "The conjunctiva that encircles the propretarsus by joining the distal margin of the distalmost protarsomere and the proximal margin of the propretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004187 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarso-pretarsal conjunctiva
relationship: AISM:0000078 AISM:0004194 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles propretarsus
relationship: AISM:0000079 AISM:0004190 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by protarsus

[Term]
id: AISM:0004192
name: mesotarso-mesopretarsal conjunctiva
def: "The conjunctiva that encircles the mesopretarsus by joining the distal margin of the distalmost mesotarsomere and the proximal margin of the mesopretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004187 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarso-pretarsal conjunctiva
relationship: AISM:0000078 AISM:0004195 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles mesopretarsus
relationship: AISM:0000079 AISM:0004189 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by mesotarsus

[Term]
id: AISM:0004193
name: metatarso-metapretarsal conjunctiva
def: "The conjunctiva that encircles the metapretarsus by joining the distal margin of the distalmost metatarsomere and the proximal margin of the metapretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0004187 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tarso-pretarsal conjunctiva
relationship: AISM:0000078 AISM:0004196 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircles metapretarsus
relationship: AISM:0000079 AISM:0004188 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by metatarsus

[Term]
id: AISM:0004194
name: propretarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the fore leg that is attached to the protarsus by the protarso-propretarsal conjunctiva." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: continuous_with AISM:0004191 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! protarso-propretarsal conjunctiva
relationship: part_of AISM:0000034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! fore leg
property_value: IAO:0000589 "cuticle of propretarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004195
name: mesopretarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the mid leg that is attached to the mesotarsus by the mesotarso-mesopretarsal conjunctiva." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: continuous_with AISM:0004192 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesotarso-mesopretarsal conjunctiva
relationship: part_of AISM:0000035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mid leg
property_value: IAO:0000589 "cuticle of mesopretarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004196
name: metapretarsus {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the appendage of the hind leg that is attached to the metatarsus by the metatarso-metapretarsal conjunctiva." [] {term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: continuous_with AISM:0004193 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metatarso-metapretarsal conjunctiva
relationship: part_of AISM:0000036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! hind leg
property_value: IAO:0000589 "cuticle of metapretarsus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004197
name: insect anus
def: "The orifice on the postabdomen at the posterior margin of the digestive tract, connected to the epiproct and paraprocti." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: UBERON:0000161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! orifice
relationship: adjacent_to AISM:0004060 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! epiproct
relationship: adjacent_to AISM:0004061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paraproct
relationship: AISM:0000079 AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! encircled by postabdomen

[Term]
id: AISM:0004198
name: gonostylus IX {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The region of the cuticle of the postabdomen that is paired and connected to the anterior region of the gonocoxa IX." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of gonostylus IX" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004199
name: cercomere {IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of the mere that is part of the cercus." [] {term:modified="2021-12-08", creation_date="2021-08-04", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000073 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mere
relationship: part_of AISM:0004165 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cercus
property_value: IAO:0000589 "cuticle of cercomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004200
name: paramero-aedeagal conjunctiva
def: "The conjunctiva of the postabdomen that joins the parameres and the aedeagus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! aedeagus
relationship: continuous_with AISM:0004064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramere
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004201
name: phallobasal-parameral conjunctiva
def: "The conjunctiva of the postabdomen that joins the phallobase and the parameres." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-03-28"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0004064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! paramere
relationship: continuous_with AISM:0004065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! phallobase
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen

[Term]
id: AISM:0004202
name: propleuro-prosternal conjunctiva
def: "The conjunctiva of the prothorax that joins the propleura and the prosternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prosternum
relationship: continuous_with AISM:0004142 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! propleuron
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0004203
name: basal wing conjunctiva
def: "The conjunctiva of the pterothorax that surrounds the wing." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: AISM:0000078 AISM:0000033 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! encircles insect wing
relationship: part_of AISM:0004166 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pterothorax

[Term]
id: AISM:0004204
name: tergo-trochantinal muscle
def: "The insect thoracic muscle that attaches to the notum and to the trochantin." [] {creation_date="2021-04-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: attaches_to AISM:0004135 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochantin
property_value: curator_notes "For muscular terminology, tergum has been traditionally used instead of notum, even though \"notum\" is the prererred term to refer to the dorsal region of the cuticle of the insect thorax that is attached to the dorsal margin of the pleuron." xsd:string {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}

[Term]
id: AISM:0004205
name: pronoto-protrochantinal muscle
def: "The tergo-trochantinal muscle that is attached to the pronotum and the protrochantin." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004204 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tergo-trochantinal muscle
relationship: attaches_to AISM:0000055 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! protrochantin
relationship: attaches_to AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum

[Term]
id: AISM:0004206
name: mesonoto-mesotrochantinal muscle
def: "The tergo-trochantinal muscle that is attached to the mesonotum and the mesotrochantin." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004204 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tergo-trochantinal muscle
relationship: attaches_to AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: attaches_to AISM:0000054 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesotrochantin

[Term]
id: AISM:0004207
name: metanoto-metatrochantinal muscle
def: "The tergo-trochantinal muscle that is attached to the metanotum and the metatrochantin." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004204 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! tergo-trochantinal muscle
relationship: attaches_to AISM:0000056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metatrochantin
relationship: attaches_to AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum

[Term]
id: AISM:0004208
name: tergo-tergal muscle
def: "The insect thoracic muscle that extends between two nota (or terga)." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004209
name: pronoto-mesonotal muscle
def: "The insect thoracic muscle that extends between the pronotum and the mesonotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004208 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tergo-tergal muscle
relationship: attaches_to AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: attaches_to AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum

[Term]
id: AISM:0004210
name: mesonoto-metanotal muscle
def: "The insect thoracic muscle that extends between the mesonotum and the metanotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004208 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tergo-tergal muscle
relationship: attaches_to AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: attaches_to AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum

[Term]
id: AISM:0004211
name: tergo-coxal muscle
def: "The insect thoracic muscle that extends between the notum (or tergum) and the coxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: attaches_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum

[Term]
id: AISM:0004212
name: tergo-trochanteral muscle
def: "The insect thoracic muscle that extends between the notum (or tergum) and the trochanter." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: attaches_to AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter

[Term]
id: AISM:0004213
name: pleuro-coxal muscle
def: "The insect thoracic muscle that attaches to the pleuron and to a coxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: attaches_to AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron

[Term]
id: AISM:0004214
name: furco-coxal muscle
def: "The insect thoracic muscle that is attached to a furca and to a coxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-08"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000077 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coxa
relationship: attaches_to AISM:0000144 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! furca

[Term]
id: AISM:0004215
name: furco-trochanteral muscle
def: "The insect thoracic muscle that is attached to a furca and to a trochanter." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-08"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000144 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! furca
relationship: attaches_to AISM:0004168 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! trochanter

[Term]
id: AISM:0004216
name: interfurcal muscle
def: "The insect thoracic muscle that extends between two furcae." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000144 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! furca

[Term]
id: AISM:0004217
name: profurco-mesofurcal muscle
def: "The insect thoracic muscle that extends between the profurca and the mesofurca." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004216 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! interfurcal muscle
relationship: attaches_to AISM:0000141 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesofurca
relationship: attaches_to AISM:0000143 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! profurca

[Term]
id: AISM:0004218
name: mesofurco-metafurcal muscle
def: "The insect thoracic muscle that extends between the mesofurca and the metafurca." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004216 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! interfurcal muscle
relationship: attaches_to AISM:0000141 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesofurca
relationship: attaches_to AISM:0000142 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metafurca

[Term]
id: AISM:0004219
name: mesonoto-mesopleural conjuntiva
def: "The noto-pleural conjunctiva that joins the mesonotum and the mesopleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004222 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! noto-pleural conjunctiva
relationship: continuous_with AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: continuous_with AISM:0004186 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopleuron

[Term]
id: AISM:0004220
name: pronoto-propleural conjunctiva
def: "The noto-pleural conjunctiva that joins the pronotum and the propleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004222 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! noto-pleural conjunctiva
relationship: continuous_with AISM:0000059 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pronotum
relationship: continuous_with AISM:0004142 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! propleuron

[Term]
id: AISM:0004221
name: metanoto-metapleural conjunctiva
def: "The noto-pleural conjunctiva that joins the metanotum and the metapleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004222 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! noto-pleural conjunctiva
relationship: continuous_with AISM:0000119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuron
relationship: continuous_with AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum

[Term]
id: AISM:0004222
name: noto-pleural conjunctiva
def: "The conjunctiva of the insect thorax that joins the notum and the pleuron." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0004128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! notum
relationship: continuous_with AISM:0004129 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pleuron
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0004223
name: third axillary sclerite
def: "The axillary sclerite that is connected via muscle to the mesopleuron and is  posterior to the first axillary sclerite." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! axillary sclerite
relationship: posterior_to AISM:0000022 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! first axillary sclerite

[Term]
id: AISM:0004224
name: ventral second axillary sclerite
def: "The axillary sclerite that is on the ventral region of the basal wing conjunctiva." [] {creation_date="2021-04-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004161 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! axillary sclerite

[Term]
id: AISM:0004225
name: mesophragma
def: "The phragma of the metanotum that attaches to muscles attached to the mesonotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002048 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! phragma
relationship: part_of AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum

[Term]
id: AISM:0004226
name: mesophragmo-abdominal tergite I muscle
def: "The insect thoracic muscle that extends between the mesophragma and the abdominal tergite I." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004208 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! tergo-tergal muscle
relationship: attaches_to AISM:0000021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite I
relationship: attaches_to AISM:0004225 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesophragma

[Term]
id: AISM:0004227
name: metafurco-abdominal sternite muscle
def: "The insect thoracic muscle that extends between the metafurca and an abdominal sternite." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002065 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! insect thoracic muscle
relationship: attaches_to AISM:0000142 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! metafurca
relationship: attaches_to AISM:0004058 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! abdominal sternite

[Term]
id: AISM:0004228
name: metaphragma
def: "The phragma of the abdominal tergite I that attaches to muscles attached to the metanotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0002048 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! phragma
relationship: part_of AISM:0000021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! abdominal tergite I

[Term]
id: AISM:0004229
name: mesonoto-metanotal conjunctiva
def: "The conjunctiva of the insect thorax that joins the mesonotum and the metanotum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesonotum
relationship: continuous_with AISM:0000169 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metanotum
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect thorax

[Term]
id: AISM:0004230
name: mesopleuro-mesocoxal conjunctiva
def: "The conjunctiva of the mesothorax that joins the mesopleuron and the mesocoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesocoxa
relationship: continuous_with AISM:0004186 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopleuron
relationship: part_of AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax

[Term]
id: AISM:0004231
name: mesopleuro-mesosternal conjunctiva
def: "The conjunctiva of the mesothorax that joins the mesopleura and the mesosternum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! conjunctiva
relationship: continuous_with AISM:0000061 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prosternum
relationship: continuous_with AISM:0004186 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesopleuron
relationship: part_of AISM:0004125 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! prothorax

[Term]
id: AISM:0004232
name: metasternum
def: "The sclerite on the ventral region of the metathorax that bears the metafurca and is attached to the metapleuro-metasternal conjunctiva." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0004130 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! sternum
relationship: continuous_with AISM:0004101 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metapleuro-metasternal conjunctiva
relationship: has_part AISM:0000142 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! metafurca

[Term]
id: AISM:0004233
name: mesosterno-mesocoxal conjunctiva
def: "The conjunctiva of the mesothorax that joins the mesosternum and the mesocoxa." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-04-09"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! conjunctiva
relationship: continuous_with AISM:0000064 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesocoxa
relationship: continuous_with AISM:0000121 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesosternum
relationship: part_of AISM:0004126 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! mesothorax

[Term]
id: AISM:0004234
name: circular pouch {creation_date="2021-07-21"}
def: "The pouch that is circular." [] {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075", creation_date="2021-07-21"}
is_a: AISM:0000160 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! cuticular pouch
relationship: has_characteristic PATO:0000411 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! circular

[Term]
id: AISM:0004235
name: ectodermal gland {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"cells or groups of cells with highly specialized secretory functions, producing a great variety of substances which are discharged at the exterior or into invaginations of the body wall\""}
def: "The region of cuticle that is continuous with glandular epithelial cells." [] {creation_date="2021-08-17", x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: continuous_with CL:0000150 {x_1.1:contributor="imiko https://orcid.org/0000-0003-2938-9075"} ! glandular epithelial cell

[Term]
id: AISM:0004236
name: unicellular ectodermal gland {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"one-celled gland usually larger than the cells surrounding it; discharges its products directly through the covering cuticula. [...] In many glands a minute cuticular ductule extends from the exterior into the body of each cell, allowing the secretion to pass out through an extremely thin layer of cuticula.\""}
def: "The ectodermal gland that is composed of one cell" [] {creation_date="2021-08-16", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004235 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ectodermal gland
relationship: has_part CL:0000000 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cell

[Term]
id: AISM:0004237
name: cuticular lobe {term:modified="2021-12-08", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"a rounded projection or protuberance\""}
def: "The cuticular evagination that is largely membranous." [] {creation_date="2021-06-14", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000128 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-06-14"} ! multicellular cuticular evagination
relationship: has_part AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-06-14"} ! conjunctiva

[Term]
id: AISM:0004238
name: multicellular ectodermal gland {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"many-celled glands may be a group of cells situated at the surface of the body, but most of them are invaginations of the body wall.\""}
def: "The ectodermal gland that is composed of multiple cells." [] {creation_date="2021-08-16", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004235 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! ectodermal gland

[Term]
id: AISM:0004239
name: occiput {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"dorsal part of the posterior surface of the head between the occipital and the postoccipital sutures\""}
def: "The region of cuticle on the posterodorsal region of the head capsule that is posterior to the occipital ridge and anterior to the postoccipital ridge." [] {creation_date="2021-08-16", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: anterior_to AISM:0004021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postoccipital ridge
relationship: posterior_to AISM:0004048 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! occipital ridge

[Term]
id: AISM:0004240
name: epicranial suture {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Y-shaped ecdysial sutures dividing vertex and frons, composed of\ncoronal suture and paired frontal sutures.\""}
def: "The cuticular suture composed of both the coronal suture and paired frontal sutures." [] {creation_date="2021-08-16", term:modified="2021-12-10", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004028 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular suture
relationship: has_part AISM:0004029 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frontal suture
relationship: has_part AISM:0004030 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coronal suture

[Term]
id: AISM:0004241
name: temple {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the part of the head above and behind the compound eyes\""}
def: "The region of cuticle that is behind the compound eye." [] {creation_date="2021-08-16", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: posterior_to AISM:0004052 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect compound eye

[Term]
id: AISM:0004242
name: insect wing region {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the principal areas of the wings differentiated in the wing-flexing insects (Neoptera), and often separated by distinct lines of folding, including the wing base, remigium, clavus, and jugum.\""}
def: "The region of cuticle of the insect wing that has wing veins, folds, and conjunctiva." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: has_part AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: has_part AISM:0004244 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing fold

[Term]
id: AISM:0004243
name: insect wing vein {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"sclerotized, tubular structure supporting the membrane of the wings\""}
def: "The region of cuticle of the insect wing that is less flexible than the wing conjunctiva." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: part_of AISM:0000033 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing

[Term]
id: AISM:0004244
name: insect wing fold {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"line along which wings fold at rest\""}
def: "The region of cuticle of the insect wing that is more flexible than the wing conjunctiva." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect region of cuticle
relationship: part_of AISM:0000033 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing

[Term]
id: AISM:0004245
name: anal field of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing field.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anal field (=vannus): posterior part of wings, usually enlarged in Polyneoptera.\""}
def: "The posterior region of the insect wing." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "vannus" EXACT []
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing region
relationship: posterior_to AISM:0004311 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cubital field of the insect wing

[Term]
id: AISM:0004246
name: anal vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anal veins: longitudinal veins of the anal field proximally articulated with 3rd axillary sclerite; usually unbranched and arranged like a fan.\""}
def: "The insect wing vein of the anal field that is posterior to the anal fold or the postcubitus and anterior to the jugal fold or the jugal veins." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: RO:0001018 AISM:0004245 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! obsolete contained in anal field of the insect wing

[Term]
id: AISM:0004247
name: costal vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Costa: main longitudinal vein along anterior wing margin, articulated with humeral plate.\""}
def: "The insect wing vein of the costal field that is anterior to the subcosta." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: anterior_to AISM:0004257 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! subcostal vein of the insect wing
relationship: RO:0001018 AISM:0004248 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! obsolete contained in costal field of the insect wing

[Term]
id: AISM:0004248
name: costal field of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing field.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Costal field (=remigium): anterior part of wing; usually largest region.\""}
def: "The anterior region of the insect wing." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "remigium" EXACT []
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing region
is_a: BSPO:0000078 ! distal region

[Term]
id: AISM:0004249
name: cubital vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Cubitus: 5th main longitudinal vein.\""}
def: "The insect wing vein that is posterior to the media and anterior to the postcubitus." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: anterior_to AISM:0004255 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postcubital vein of the insect wing
relationship: posterior_to AISM:0004252 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! medial vein of the insect wing

[Term]
id: AISM:0004250
name: jugal field of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing field.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Jugal field: small wing region posteriorly adjacent with anal field.\""}
def: "The insect wing region that is posterior to the jugal fold." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing region
relationship: posterior_to AISM:0004253 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! jugal fold of the insect wing

[Term]
id: AISM:0004251
name: jugal vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Jugal veins: veins of the jugal field.\""}
def: "The insect wing vein in the jugal field, posterior to the jugal fold or to the anal veins." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: RO:0001018 AISM:0004250 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! obsolete contained in jugal field of the insect wing

[Term]
id: AISM:0004252
name: medial vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Media: 4th main longitudinal vein.\""}
def: "The insect wing vein that is posterior to some radius and anterior to some cubitus." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: anterior_to AISM:0004249 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cubital vein of the insect wing
relationship: posterior_to AISM:0004256 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! radial vein of the insect wing

[Term]
id: AISM:0004253
name: jugal fold of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing fold.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect wing fold that separates the anal field and the jugal field." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "plica jugalis" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Plica jugalis: separates the anal and jugal fields.\""}
is_a: AISM:0004244 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing fold

[Term]
id: AISM:0004254
name: anal fold of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing fold.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect wing fold that is posterior to the postcubitus and separates the costal field and the anal field." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "claval furrow" EXACT [] {AISM:0000171="Chapman RF (2012) The Insects: Structure and Function. Fifth Edition. Cambridge University Press. 959 pp. \n\nhttps://doi.org/10.1017/CBO9781139035460\n\n\"longitudinal flexion line which runs close to the CuP. This furrow allows the posterior part of the wing to flap up and down with respect to the rest of the wing.\""}
synonym: "plica vannalis" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Plica vannalis: separates the costal and anal fields.\""}
is_a: AISM:0004244 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing fold
relationship: posterior_to AISM:0004255 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postcubital vein of the insect wing

[Term]
id: AISM:0004255
name: postcubital vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Postcubitus: posteriormost longitudinal vein of the remigium.\""}
def: "The insect wing vein that is posterior to the cubitus and anterior to the anal fold or the anal vein." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: posterior_to AISM:0004249 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cubital vein of the insect wing

[Term]
id: AISM:0004256
name: radial vein of the insect wing {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Radius: 3rd main longitudinal vein.\"", IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect wing vein that is posterior to the subcosta and anterior to the media." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: anterior_to AISM:0004252 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! medial vein of the insect wing
relationship: posterior_to AISM:0004257 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! subcostal vein of the insect wing

[Term]
id: AISM:0004257
name: subcostal vein of the insect wing {IAO:0000232="Modified 2023-01-09: specifying insect wing vein.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Subcosta: 2nd main longitudinal vein, following costal vein.\""}
def: "The insect wing vein that is posterior to the costa and anterior to the radius." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004243 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing vein
relationship: anterior_to AISM:0004256 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! radial vein of the insect wing
relationship: posterior_to AISM:0004247 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! costal vein of the insect wing

[Term]
id: AISM:0004258
name: axillary region of the insect wing {IAO:0000232="Modified 2023-01-21: specifying insect wing region.\njgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"The region of the wing base containing the axillary sclerites\""}
def: "The proximal region of the insect wing." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing region
is_a: BSPO:0000078 ! distal region

[Term]
id: AISM:0004259
name: basal fold of the insect wing {comment="Modified 2023-01-21: specifying insect wing fold.\njgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect wing fold that is distal to the axillary region." [] {creation_date="2021-09-07", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "plica basalis" EXACT [] {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"Plica basalis (bf).The basal fold of the wing, or line of flection between the base of the mediocubital fold and the axillary region, forming a prominent convex fold in the flexed wing extending between the median plates from the articulation of radius with the second axillary to the articulation of the vannal veins with the third axillary.\""}
is_a: AISM:0004244 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect wing fold
relationship: distal_to AISM:0004258 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! axillary region of the insect wing

[Term]
id: AISM:0004260
name: pretarsal claw {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ungues: pretarsal claws; unpaired in Collembola and Protura, usually paired in Diplura and Insecta.\""}
def: "The sclerite that is part of the pretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
synonym: "ungues" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Ungues: pretarsal claws; unpaired in Collembola and Protura, usually paired in Diplura and Insecta.\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: part_of AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus

[Term]
id: AISM:0004261
name: empodium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Empodium: a median process between the claws and pulvilli (if present). It arises from the distal end of the unguitractor plate, is spine-shaped or lobe-like and is sometimes similar in form to the pulvilli (“empodial pulvillus”).\" p. 43.", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"a spine- or lobelike process of the unguitractor\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticular protrusion that is part of the pretarsus, ventral to the tarsal claws and medial to the pulvilli (if present)." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19", IAO:0000232="Modified 2023-01-11: added medial to pulvilli.\njgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular protrusion
relationship: AISM:0000012 AISM:0004308 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! medial_to pulvillus
relationship: part_of AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: ventral_to AISM:0004260 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsal claw
property_value: IAO:0000589 "cuticle of empodium" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004262
name: frontoclypeal sulcus
def: "The sulcus that coincides with the frontoclypeal ridge and separated the frons from the clypeus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
synonym: "epistomal sulcus" EXACT [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "epistomal suture" EXACT [] {AISM:0000171="Lawrence J, Ślipiński A (2013) Adult morphology. In: Australian beetles volume 1: morphology, classification and keys. CSIRO Publishing, 30–63. \n\nhttps://www.publish.csiro.au/book/6466/\n\n[adjusted] the 'suture' separating the clypeus from the frons, representing the internal invagination of the epistomal ridge."}
synonym: "frontoclypeal suture" EXACT [] {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the suture between the frons and the clypeus\""}
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular sulcus
relationship: adjacent_to AISM:0004019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! clypeus
relationship: adjacent_to AISM:0004020 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! frons
relationship: RO:0002008 AISM:0004034 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! coincident with frontoclypeal ridge

[Term]
id: AISM:0004263
name: cibarium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Anterior part of preoral space between epipharynx and hypopharynx.\"", creation_date="2021-12-15"}
def: "The conjunctiva that is part of the head capsule and is continuous with the epipharynx and the hypopharynx." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-12-15"}
is_a: AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-12-15"} ! conjunctiva
relationship: continuous_with AISM:0000093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-12-15"} ! hypopharynx
relationship: continuous_with AISM:0000105 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-12-15"} ! epipharynx
relationship: part_of AISM:0000019 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-12-15"} ! head capsule

[Term]
id: AISM:0004264
name: epistoma {creation_date="2022-02-21", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the oral margin or sclerite directly behind the labrum\""}
def: "The region of cuticle that is posterior to the cuticle of the labrum." [] {creation_date="2022-02-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-02-21"} ! insect region of cuticle
relationship: posterior_to AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-02-21"} ! labrum

[Term]
id: AISM:0004265
name: subgenal sulcus {creation_date="2022-02-21", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the lateral submarginal groove of the cranium just above the bases of the gnathal appendages, extending between the anterior tentorial pit and the posterior tentorial pit\""}
def: "The cuticular sulcus that is adjacent to the subgena and coincides with the subgenal ridge." [] {creation_date="2022-02-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "subgenal suture" EXACT []
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-02-21"} ! cuticular sulcus
relationship: adjacent_to AISM:0004027 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-02-21"} ! subgena
relationship: RO:0002008 AISM:0004032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-02-21"} ! coincident with subgenal ridge

[Term]
id: AISM:0004266
name: antennomere {creation_date="2022-06-20", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticle of a mere that is part of the cuticle of the antenna." [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000073 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! mere
relationship: part_of AISM:0000032 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! antenna
property_value: curator_notes "Given the high number of antennomeres occurring in some taxa, Arabic numerals are used instead of Roman numerals for practicality reasons." xsd:string {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"}
property_value: IAO:0000589 "cuticle of antennomere" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004267
name: postoccipital sulcus {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n[as postoccipital suture] \"posterior submarginal groove having the posterior tentorial pits in its lower end, separatig the postocciput from the rest of the cranium\"", creation_date="2022-06-17"}
def: "The cuticular sulcus that coincides with the postoccipital ridge and is posterior to the occiput and anterior to the postocciput." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"}
synonym: "postoccipital suture" EXACT [] {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"posterior submarginal groove having the posterior tentorial pits in its lower end, separatig the postocciput from the rest of the cranium\""}
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! cuticular sulcus
relationship: anterior_to AISM:0004045 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! postocciput
relationship: posterior_to AISM:0004239 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! occiput
relationship: RO:0002008 AISM:0004021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! coincident with postoccipital ridge

[Term]
id: AISM:0004268
name: gular sulcus {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n[as gular suture] \"the line or division between the gula and the genae\""}
def: "The cuticular sulcus that coincides with the gular ridge, separating the gula fron the gena" [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"}
synonym: "gular suture" EXACT [] {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the line or division between the gula and the genae\""}
is_a: AISM:0000162 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! cuticular sulcus
relationship: adjacent_to AISM:0004026 {x_1.1:contributor="2022-06-17", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! gena
relationship: adjacent_to AISM:0004035 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! gula
relationship: RO:0002008 AISM:0004036 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-17"} ! coincident with gular ridge

[Term]
id: AISM:0004269
name: mandibular incisor lobe {creation_date="2022-06-20", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"toothed distal lobe of mandible\""}
def: "The region of the cuticle that is distal and medial on the cuticle of the insect mandible." [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! insect region of cuticle

[Term]
id: AISM:0004270
name: mandibular molar lobe {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"the ridged or roughened grinding surface of the mandible\"", creation_date="2022-06-20"}
def: "The region of the cuticle that is proximal and medial on the cuticle of the insect mandible." [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "mola" EXACT [] {AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\nmola = molar lobe = \"the ridged or roughened grinding surface of the mandible\""}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! insect region of cuticle
is_a: BSPO:0000078 ! distal region

[Term]
id: AISM:0004271
name: prostheca {creation_date="2022-06-20", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"mandibular region set with hair\""}
def: "The cuticular lobe of the cuticle of the insect mandible between the mandibular molar lobe and the mandibular incisor lobe." [] {creation_date="2022-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "lacinia mobilis" EXACT [] {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"An articulated mesal appendage, the lacinia mobilis or prostheca, occurs in several groups. It can be sclerotized or largely membranous and is often equipped with microtrichia.\""}
is_a: AISM:0004237 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! cuticular lobe
relationship: anterior_to AISM:0004270 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! mandibular molar lobe
relationship: part_of AISM:0000043 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! insect mandible
relationship: posterior_to AISM:0004269 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-20"} ! mandibular incisor lobe

[Term]
id: AISM:0004272
name: basistipes {creation_date="2022-06-23", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Basistipes: basolateral part of stipes.\""}
def: "The region of cuticle on the lateral region of the cuticle of stipes, adjacent to the distal margin of the cuticle of the cardo, to the proximal margin of the cuticle of the palpifer, and adjacent to the proximal margin of the mediostipes." [] {creation_date="2022-06-23", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-23"} ! insect region of cuticle
is_a: BSPO:0000078 ! distal region

[Term]
id: AISM:0004273
name: mediostipes {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Mediostipes: mesal part of stipes.\""}
def: "The region of cuticle on the medial region of the cuticle of stipes, adjacent to the distal margin of the cuticle of the basistipes, and to the proximal margin of the cuticle of the galea and the lacinia." [] {creation_date="2022-06-23", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-23"} ! insect region of cuticle
is_a: BSPO:0000078 ! distal region

[Term]
id: AISM:0004274
name: maxillary gland {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"Glands present in some insects opening mesally at the bases of the maxillae\""}
def: "The ectodermal gland continuous with the proximal region of the cuticle of the cardo." [] {creation_date="2022-06-23", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004235 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-23"} ! ectodermal gland

[Term]
id: AISM:0004275
name: hypopharyngeal sclerite
def: "The sclerite that is continuous with the hypopharynx." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! insect sclerite
relationship: continuous_with AISM:0000093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! hypopharynx

[Term]
id: AISM:0004276
name: thoracic foramen {creation_date="2022-06-27"}
def: "The arthropod foramen that is part of the cuticle of the insect thorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000197 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! arthropod foramen
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! insect thorax

[Term]
id: AISM:0004277
name: anterior prothoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the anterior margin of the cuticle of the prothorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004278
name: posterior prothoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the posterior margin of the cuticle of the prothorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004279
name: anterior mesothoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the anterior margin of the cuticle of the mesothorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004280
name: posterior mesothoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the posterior margin of the cuticle of the mesothorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004281
name: posterior metathoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the posterior margin of the cuticle of the metathorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004282
name: anterior metathoracic foramen {creation_date="2022-06-27"}
def: "The thoracic foramen that is at the anterior margin of the cuticle of the metathorax." [] {creation_date="2022-06-27", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004276 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2022-06-27"} ! thoracic foramen

[Term]
id: AISM:0004283
name: insect body segment {creation_date="2023-01-09", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"segment, subdivision of the body between areas of flexibility associated with muscle attachments\"", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect region of integument that is continuous with conjunctiva and attached to somatic muscle." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/fbcvq.html?query=FBbt\:00000003 "segment" {def="One of the repeated divisions of the whole organism."}
xref: http://purl.obolibrary.org/obo/HAO_0000929 "segment" {def="An anatomical structure that is metameric and is connected to other metameric subdivisions by muscles and is delimited by its sclerites."}
is_a: UBERON:6007284 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect region of integument
relationship: attaches_to UBERON:0014895 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! somatic muscle
relationship: continuous_with AISM:0000004 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! conjunctiva

[Term]
id: AISM:0004284
name: insect appendage segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Nichols, S. W. (1989) Torre-Bueno glossary of entomology. New York Entomological Society. 840 pp.\n\nhttps://ipmhouse.tamu.edu/files/2021/03/The-Torre-Bueno-Glossary-of-Entomology.pdf\n\n\"segment, subdivision of an appendage between areas of flexibility associated with muscle attachments\""}
def: "The insect region of integument that has a ring sclerirte, continuous with ring conjunctiva, and attached to somatic muscle." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: UBERON:6007284 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect region of integument
relationship: attaches_to UBERON:0014895 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! somatic muscle
relationship: continuous_with AISM:0000102 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! ring conjunctiva
relationship: has_part AISM:0000062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! ring sclerite

[Term]
id: AISM:0004285
name: insect cephalic segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that is part of the insect head." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: https://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000006 "head segment" {def="Any segment (FBbt:00000003) that is part of some head (FBbt:00000004)."}
is_a: AISM:0004283 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect body segment
is_a: PR:000050567 ! protein-containing material entity
relationship: has_part AISM:0000107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect head

[Term]
id: AISM:0004286
name: insect thoracic segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that is part of the insect thorax." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000016 "thoracic segment" {def="Any segment (FBbt:00000003) that is part of some thorax (FBbt:00000015)."}
is_a: AISM:0004283 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect body segment
relationship: has_part AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect thorax

[Term]
id: AISM:0004287
name: insect abdominal segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that is part of the insect abdomen." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000021 "abdominal segment" {def="Metameric subdivision of the abdomen."}
is_a: AISM:0004283 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect body segment
relationship: has_part AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdomen

[Term]
id: AISM:0004288
name: insect abdominal segment I {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that is part of the insect abdomen and is posterior to the insect metathoracic segment." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000022 "abdominal segment 1" {def="Most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0000021 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite I
relationship: has_part AISM:0004100 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite I
relationship: posterior_to AISM:0004300 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect metathoracic segment

[Term]
id: AISM:0004289
name: insect abdominal segment II {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment I and composed of abdominal tergite II and abdominal sternite II." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000023 "abdominal segment 2" {def="Second most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004085 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite II
relationship: has_part AISM:0004104 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite II
relationship: posterior_to AISM:0004288 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment I

[Term]
id: AISM:0004290
name: insect abdominal segment III {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment II and composed of abdominal tergite III and abdominal sternite III." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000024 "abdominal segment 3" {def="Third most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite III
relationship: has_part AISM:0004105 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite III
relationship: posterior_to AISM:0004289 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment II

[Term]
id: AISM:0004291
name: insect abdominal segment IV {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment III and composed of abdominal tergite IV and abdominal sternite IV." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000025 "abdominal segment 4" {def="Fourth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004090 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite IV
relationship: has_part AISM:0004106 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite IV
relationship: posterior_to AISM:0004290 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment III

[Term]
id: AISM:0004292
name: insect abdominal segment V {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment IV and composed of abdominal tergite V and abdominal sternite V." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000026 "abdominal segment 5" {def="Fifth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004091 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite V
relationship: has_part AISM:0004107 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite V
relationship: posterior_to AISM:0004291 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment IV

[Term]
id: AISM:0004293
name: insect abdominal segment VI {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment V and composed of abdominal tergite VI and abdominal sternite VI." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000027 "abdominal segment 6" {def="Sixth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite VI
relationship: has_part AISM:0004108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite VI
relationship: posterior_to AISM:0004292 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment V

[Term]
id: AISM:0004294
name: insect abdominal segment VII {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment VI and composed of abdominal tergite VII and abdominal sternite VII." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000028 "abdominal segment 7" {def="Seventh most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004095 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite VII
relationship: has_part AISM:0004109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite VII
relationship: posterior_to AISM:0004293 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment VI

[Term]
id: AISM:0004295
name: insect abdominal segment VIII {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment VII and composed of abdominal tergite VIII and abdominal sternite VIII." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000029 "abdominal segment 8" {def="Eigth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004097 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite VIII
relationship: has_part AISM:0004110 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite VIII
relationship: posterior_to AISM:0004294 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment VII

[Term]
id: AISM:0004296
name: insect abdominal segment IX {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment VIII and composed of abdominal tergite IX and abdominal sternite IX." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000030 "abdominal segment 9" {def="Ninth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: has_part AISM:0004117 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal tergite IX
relationship: has_part AISM:0004119 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! abdominal sternite IX
relationship: posterior_to AISM:0004295 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment VIII

[Term]
id: AISM:0004297
name: insect abdominal segment X {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect abdominal segment that is posterior to the insect abdominal segment IX and composed of abdominal tergite X and abdominal sternite X." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
xref: http://flybase.org/cgi-bin/cvreport.pl?cvterm=FBbt\:00000031 "abdominal segment 10" {def="Tenth most anterior segment of the abdomen."}
is_a: AISM:0004287 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment
relationship: posterior_to AISM:0004296 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect abdominal segment IX

[Term]
id: AISM:0004298
name: insect prothoracic segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that corresponds to the prothorax and is posterior to the insect cephalic segment." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004286 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect thoracic segment
relationship: posterior_to AISM:0004285 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect cephalic segment

[Term]
id: AISM:0004299
name: insect mesothoracic segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that corresponds to the mesothorax and is posterior to the insect prothoracic segment." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004286 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect thoracic segment
relationship: posterior_to AISM:0004298 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect prothoracic segment

[Term]
id: AISM:0004300
name: insect metathoracic segment {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The insect body segment that corresponds to the metathorax and is posterior to the insect mesothoracic segment." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004286 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect thoracic segment
relationship: posterior_to AISM:0004299 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect mesothoracic segment

[Term]
id: AISM:0004301
name: gonocoxite {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\"", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The bilaterally paired insect sclerite of the postabdomen, attached to either the abdominal tergite VIII or IX." [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
synonym: "coxopodite" EXACT [] {creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Coxopodite (=valvifer, gonocoxa, gonocoxite): short basal piece of ovipositor elements of female genital segments VIII and IX.\""}
is_a: AISM:0000003 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! insect sclerite
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0004056 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! postabdomen
property_value: IAO:0000589 "cuticle of gonocoxite" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004302
name: insect mouth {AISM:0000171="Snodgrass RE (1993) Principles of Insect Morphology. Cornell University Press, 768 pp.\n\nhttps://www.jstor.org/stable/10.7591/j.ctv1nhm1j\n\n\"Mouth. The external opening of the stomodaeum, situated in the ventral wall of the head between the labrum and the hypopharynx.\"", creation_date="2023-01-09", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The mouth that is surrounded by insect mandibles, labium, and labrum and is anterior to the hypopharynx." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883 2023-03-30", creation_date="2024-01-25"}
synonym: "preoral cavity" EXACT [] {creation_date="2023-01-09", AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"The preoral cavity is the space enclosed between the labrum and labium and the paired mandibles and maxillae\"", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: UBERON:0000165 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! mouth
relationship: anterior_to AISM:0000093 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! hypopharynx
relationship: surrounded_by AISM:0000042 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! labrum
relationship: surrounded_by AISM:0000043 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! insect mandible
relationship: surrounded_by AISM:0000087 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-09"} ! labium

[Term]
id: AISM:0004303
name: insect gland opening
def: "The orifice that is continuous with an ectodermal gland." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883 2023-03-30", creation_date="2024-01-25"}
is_a: UBERON:0000161 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! orifice
relationship: continuous_with AISM:0004235 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! ectodermal gland

[Term]
id: AISM:0004304
name: cuticular sensilla {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Sensilla are the basal functional and structural units of cuticular mechanoreceptors and chemoreceptors. They include the cuticular component (e.g., the cuticle of a seta), the sensory neuron (or neurons), the associated sheath cells with the cavities they enclose and the structures they produce\" p. 5.", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
def: "The region of cuticle that is attached to arthropod sensillum." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-10-11"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! insect region of cuticle
is_a: UBERON:0000061 ! anatomical structure
relationship: attaches_to UBERON:0002536 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! arthropod sensillum

[Term]
id: AISM:0004305
name: sensilla ampullacea {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Modified type of cuticular sensilla sunk below the external cuticular surface\"", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
def: "The cuticular sensilla that is dilated." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883 2023-03-30", creation_date="2024-01-25"}
xref: http://purl.obolibrary.org/obo/HAO_0001098 "basiconic capitate peg sensillum" {def="Mushroom-shaped sensory structure on the flagellum, particularly the\nclava; sometimes called the sensilla ampullacea."}
is_a: AISM:0004304 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular sensilla
relationship: has_characteristic PATO:0001571 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! dilated

[Term]
id: AISM:0004306
name: stridulatory file {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
def: "The region of the cuticle that bears an anatomical collection composed of cuticular carinae." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
is_a: AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! insect region of cuticle
relationship: has_member AISM:0000501 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular carina
relationship: has_part UBERON:0034925 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! anatomical collection

[Term]
id: AISM:0004307
name: pretarsal seta {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
def: "The cuticular seta that is adjacent to the cuticle of the pretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
is_a: AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! cuticular seta
relationship: adjacent_to AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"} ! pretarsus

[Term]
id: AISM:0004308
name: pulvillus {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Pulvilli: smooth or hairy paired lateral membranous lobes below the claws\". p. 44.", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The cuticular protrusion that is part of the pretarsus, ventral to the tarsal claws." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2021-11-19"}
is_a: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! cuticular protrusion
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! bilaterally paired
relationship: part_of AISM:0000047 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsus
relationship: ventral_to AISM:0004260 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"} ! pretarsal claw
property_value: IAO:0000589 "cuticle of pulvillus" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004309
name: arolium {AISM:0000171="Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Arolium: the median hollow lobe of the pretarsus. It can be completely membranous or partly sclerotized.\" p. 42.\n\"unpaired, between the claws\" p. 40.", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11", IAO:0000232="Modified 2023-04-13: removed ‘cuticle of’ from label.\nstarasov https://orcid.org/0000-0001-5237-2330"}
def: "The medial cuticular protrusion of the pretarsus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-11"}
property_value: IAO:0000589 "cuticle of arolium" xsd:string {creation_date="2023-04-13"}

[Term]
id: AISM:0004310
name: radial field of the insect wing
def: "The region of the insect wing that is posterior to the costal field of the insect wing." [] {creation_date="2023-01-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! insect wing region
relationship: posterior_to AISM:0004248 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! costal field of the insect wing

[Term]
id: AISM:0004311
name: cubital field of the insect wing
def: "The region of the insect wing that is posterior to the medial field of the insect wing." [] {creation_date="2023-01-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! insect wing region
relationship: posterior_to AISM:0004312 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! medial field of the insect wing

[Term]
id: AISM:0004312
name: medial field of the insect wing
def: "The region of the insect wing that is posterior to the radial field of the insect wing." [] {creation_date="2023-01-21", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0004242 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! insect wing region
relationship: posterior_to AISM:0004310 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-01-21"} ! radial field of the insect wing

[Term]
id: AISM:0004313
name: tracheal gill {AISM:0000171="http://insecta.bio.spbu.ru/z/antidictionary/tergalii&gills.htm\n\n\"Paraspiracular tracheal gill. Paired abdominal appendage, whose trachea arises either directly from the spiracular trachea of the same abdominal segment, or from the nearest point of tracheae branching\"", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
def: "The bilaterally paired cuticular protrusion that contains insect tracheae." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
is_a: AISM:0000008 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! cuticular protrusion
relationship: has_characteristic PATO:0040024 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! bilaterally paired
relationship: has_part AISM:0000091 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! insect trachea

[Term]
id: AISM:0004314
name: insect thoracic spiracle {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
def: "The insect spiracle that is part of the insect thorax." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
is_a: AISM:0000135 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! insect spiracle
relationship: part_of AISM:0000108 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! insect thorax

[Term]
id: AISM:0004315
name: insect abdominal insect spiracle {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
def: "The insect spiracle that is part of the insect abdomen." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"}
is_a: AISM:0000135 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! insect spiracle
relationship: part_of AISM:0000109 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2023-02-05"} ! insect abdomen

[Term]
id: AISM:0004316
name: insect external male genitalia {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"}
def: "The external male genitalia with insect cuticle and composed of phallobase, phallobasal-parameral conjunctiva, paramere (or parameres), paramero-aedeagal conjunctiva, aedeagus, and endophallus." [] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", x_1.1:creator="2024-01-12"}
is_a: UBERON:0004053 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! external male genitalia
relationship: has_component AISM:0000174 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! insect region of cuticle
relationship: has_part AISM:0004062 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! aedeagus
relationship: has_part AISM:0004063 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! endophallus
relationship: has_part AISM:0004065 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! phallobase
relationship: has_part AISM:0004200 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! paramero-aedeagal conjunctiva
relationship: has_part AISM:0004201 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-01-12"} ! phallobasal-parameral conjunctiva

[Term]
id: AISM:0004317
name: deflexed {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
def: "A quality inhering in a bearer by virtue of the bearer's surface becoming bent or curving downward or backward." [Oxford Languages through Google.] {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"}
is_a: PATO:0001591 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-02-14"} ! curvature

[Term]
id: AISM:0004318
name: antenna with 10 antennomeres {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The antenna that has scapus, pedicellus, and flagellomeres 1-8, and does not have flagellomere 9." [] {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna
relationship: has_part AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 2
relationship: has_part AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 3
relationship: has_part AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 4
relationship: has_part AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 5
relationship: has_part AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 6
relationship: has_part AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 7
relationship: has_part AISM:0000340 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-06-20"} ! flagellomere 8

[Term]
id: AISM:0004319
name: antenna with 11 antennomeres {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The antenna that has scapus, pedicellus, and flagellomeres 1-9." [] {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000032 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! antenna
relationship: has_part AISM:0000334 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 2
relationship: has_part AISM:0000335 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 3
relationship: has_part AISM:0000336 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 4
relationship: has_part AISM:0000337 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 5
relationship: has_part AISM:0000338 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 6
relationship: has_part AISM:0000339 {x_1.1:contributor="gmontanaro https://orcid.org/0000-0003-0836-1364", creation_date="2023-05-05"} ! flagellomere 7
relationship: has_part AISM:0000340 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-06-20"} ! flagellomere 8

[Term]
id: AISM:0004320
name: empodial seta {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
def: "The cuticular seta that is adjacent to the cuticle of the empodium." [] {creation_date="2024-06-20", x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883"}
is_a: AISM:0000039 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-06-20"} ! cuticular seta
relationship: adjacent_to AISM:0004261 {x_1.1:contributor="jgiron https://orcid.org/0000-0002-0851-6883", creation_date="2024-06-20"} ! empodium

[Term]
id: BFO:0000001
name: entity
property_value: BFO:0000179 "entity" xsd:string
property_value: BFO:0000180 "Entity" xsd:string
property_value: editor_note "BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81" xsd:string
property_value: editor_note "Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000004", comment="per discussion with Barry Smith", seeAlso="http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf"}
property_value: IAO:0000112 "Julius Caesar" xsd:string
property_value: IAO:0000112 "the Second World War" xsd:string
property_value: IAO:0000112 "Verdi’s Requiem" xsd:string
property_value: IAO:0000112 "your body mass index" xsd:string
property_value: IAO:0000600 "An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/001-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000002
name: continuant
def: "An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts." []
is_a: BFO:0000001 ! entity
disjoint_from: BFO:0000003 ! occurrent
relationship: part_of BFO:0000002 {all_only="true"} ! continuant
property_value: BFO:0000179 "continuant" xsd:string
property_value: BFO:0000180 "Continuant" xsd:string
property_value: editor_note "BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240" xsd:string
property_value: editor_note "Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000007"}
property_value: IAO:0000600 "A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"}
property_value: IAO:0000601 "if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"}
property_value: IAO:0000601 "if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"}
property_value: IAO:0000601 "if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"}
property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/009-002"}
property_value: IAO:0000602 "(forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/126-001"}
property_value: IAO:0000602 "(forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/008-002"}
property_value: IAO:0000602 "(forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/011-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000003
name: occurrent
def: "An entity that has temporal parts and that happens, unfolds or develops through time." []
is_a: BFO:0000001 ! entity
relationship: part_of BFO:0000003 {all_only="true"} ! occurrent
property_value: BFO:0000179 "occurrent" xsd:string
property_value: BFO:0000180 "Occurrent" xsd:string
property_value: editor_note "BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region" xsd:string
property_value: editor_note "BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players." xsd:string
property_value: editor_note "Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000006", comment="per discussion with Barry Smith"}
property_value: editor_note "Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000012"}
property_value: IAO:0000589 "processual entity (BFO)" xsd:string
property_value: IAO:0000600 "An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/077-002"}
property_value: IAO:0000601 "b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"}
property_value: IAO:0000601 "Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"}
property_value: IAO:0000602 "(forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/108-001"}
property_value: IAO:0000602 "(forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/079-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000004
name: independent continuant
def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"}
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: part_of BFO:0000004 {all_only="true"} ! independent continuant
property_value: BFO:0000179 "ic" xsd:string
property_value: BFO:0000180 "IndependentContinuant" xsd:string
property_value: IAO:0000112 "a chair" xsd:string
property_value: IAO:0000112 "a heart" xsd:string
property_value: IAO:0000112 "a leg" xsd:string
property_value: IAO:0000112 "a molecule" xsd:string
property_value: IAO:0000112 "a spatial region" xsd:string
property_value: IAO:0000112 "an atom" xsd:string
property_value: IAO:0000112 "an orchestra." xsd:string
property_value: IAO:0000112 "an organism" xsd:string
property_value: IAO:0000112 "the bottom right portion of a human torso" xsd:string
property_value: IAO:0000112 "the interior of your mouth" xsd:string
property_value: IAO:0000589 "anatomical entity (BFO)" xsd:string
property_value: IAO:0000601 "For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"}
property_value: IAO:0000601 "For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"}
property_value: IAO:0000602 "(forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/018-002"}
property_value: IAO:0000602 "(forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/134-001"}
property_value: IAO:0000602 "(iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/017-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000006
name: spatial region
is_a: BFO:0000141 ! immaterial entity
property_value: BFO:0000179 "s-region" xsd:string
property_value: BFO:0000180 "SpatialRegion" xsd:string
property_value: editor_note "BFO 2 Reference: Spatial regions do not participate in processes." xsd:string
property_value: editor_note "Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000002", comment="per discussion with Barry Smith"}
property_value: IAO:0000600 "A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/035-001"}
property_value: IAO:0000601 "All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/036-001"}
property_value: IAO:0000602 "(forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/036-001"}
property_value: IAO:0000602 "(forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/035-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000009
name: two-dimensional spatial region
is_a: BFO:0000006 ! spatial region
property_value: BFO:0000179 "2d-s-region" xsd:string
property_value: BFO:0000180 "TwoDimensionalSpatialRegion" xsd:string
property_value: IAO:0000112 "an infinitely thin plane in space." xsd:string
property_value: IAO:0000112 "the surface of a sphere-shaped part of space" xsd:string
property_value: IAO:0000600 "A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/039-001"}
property_value: IAO:0000602 "(forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/039-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000015
name: process
def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"}
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent
property_value: BFO:0000179 "process" xsd:string
property_value: BFO:0000180 "Process" xsd:string
property_value: editor_note "BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)" xsd:string
property_value: IAO:0000112 "a process of cell-division, \\ a beating of the heart" xsd:string
property_value: IAO:0000112 "a process of meiosis" xsd:string
property_value: IAO:0000112 "a process of sleeping" xsd:string
property_value: IAO:0000112 "the course of a disease" xsd:string
property_value: IAO:0000112 "the flight of a bird" xsd:string
property_value: IAO:0000112 "the life of an organism" xsd:string
property_value: IAO:0000112 "your process of aging." xsd:string
property_value: IAO:0000602 "(iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/083-003"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000016
name: disposition
is_a: BFO:0000017 ! realizable entity
disjoint_from: BFO:0000023 ! role
property_value: BFO:0000179 "disposition" xsd:string
property_value: BFO:0000180 "Disposition" xsd:string
property_value: editor_note "BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type." xsd:string
property_value: IAO:0000112 "an atom of element X has the disposition to decay to an atom of element Y" xsd:string
property_value: IAO:0000112 "certain people have a predisposition to colon cancer" xsd:string
property_value: IAO:0000112 "children are innately disposed to categorize objects in certain ways." xsd:string
property_value: IAO:0000112 "the cell wall is disposed to filter chemicals in endocytosis and exocytosis" xsd:string
property_value: IAO:0000600 "b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"}
property_value: IAO:0000601 "If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"}
property_value: IAO:0000602 "(forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/063-002"}
property_value: IAO:0000602 "(forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/062-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000017
name: realizable entity
def: "A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." []
is_a: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000019 ! quality
relationship: part_of BFO:0000017 {all_only="true"} ! realizable entity
property_value: BFO:0000179 "realizable" xsd:string
property_value: BFO:0000180 "RealizableEntity" xsd:string
property_value: IAO:0000112 "the disposition of this piece of metal to conduct electricity." xsd:string
property_value: IAO:0000112 "the disposition of your blood to coagulate" xsd:string
property_value: IAO:0000112 "the function of your reproductive organs" xsd:string
property_value: IAO:0000112 "the role of being a doctor" xsd:string
property_value: IAO:0000112 "the role of this boundary to delineate where Utah and Colorado meet" xsd:string
property_value: IAO:0000600 "To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"}
property_value: IAO:0000601 "All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"}
property_value: IAO:0000602 "(forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/060-002"}
property_value: IAO:0000602 "(forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/058-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000019
name: quality
namespace: bfo
is_a: BFO:0000020 ! specifically dependent continuant
relationship: part_of BFO:0000019 {all_only="true"} ! quality
property_value: BFO:0000179 "quality" xsd:string
property_value: BFO:0000180 "Quality" xsd:string
property_value: IAO:0000112 "the ambient temperature of this portion of air" xsd:string
property_value: IAO:0000112 "the color of a tomato" xsd:string
property_value: IAO:0000112 "the length of the circumference of your waist" xsd:string
property_value: IAO:0000112 "the mass of this piece of gold." xsd:string
property_value: IAO:0000112 "the shape of your nose" xsd:string
property_value: IAO:0000112 "the shape of your nostril" xsd:string
property_value: IAO:0000600 "a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"}
property_value: IAO:0000601 "If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"}
property_value: IAO:0000602 "(forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/105-001"}
property_value: IAO:0000602 "(forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/055-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000020
name: specifically dependent continuant
def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"}
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent continuant
property_value: BFO:0000179 "sdc" xsd:string
property_value: BFO:0000180 "SpecificallyDependentContinuant" xsd:string
property_value: editor_note "Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc." xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/0000005", comment="per discussion with Barry Smith"}
property_value: IAO:0000112 "of one-sided specifically dependent continuants: the mass of this tomato" xsd:string
property_value: IAO:0000112 "of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates." xsd:string
property_value: IAO:0000112 "Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key" xsd:string
property_value: IAO:0000112 "the disposition of this fish to decay" xsd:string
property_value: IAO:0000112 "the function of this heart: to pump blood" xsd:string
property_value: IAO:0000112 "the mutual dependence of proton donors and acceptors in chemical reactions [79" xsd:string
property_value: IAO:0000112 "the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction" xsd:string
property_value: IAO:0000112 "the pink color of a medium rare piece of grilled filet mignon at its center" xsd:string
property_value: IAO:0000112 "the role of being a doctor" xsd:string
property_value: IAO:0000112 "the shape of this hole." xsd:string
property_value: IAO:0000112 "the smell of this portion of mozzarella" xsd:string
property_value: IAO:0000602 "(iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/050-003"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000023
name: role
def: "A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts." []
is_a: BFO:0000017 ! realizable entity
property_value: BFO:0000179 "role" xsd:string
property_value: BFO:0000180 "Role" xsd:string
property_value: editor_note "BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals –  professor, sergeant, nurse – only during certain phases in their lives." xsd:string
property_value: IAO:0000112 "John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married." xsd:string
property_value: IAO:0000112 "the priest role" xsd:string
property_value: IAO:0000112 "the role of a boundary to demarcate two neighboring administrative territories" xsd:string
property_value: IAO:0000112 "the role of a building in serving as a military target" xsd:string
property_value: IAO:0000112 "the role of a stone in marking a property boundary" xsd:string
property_value: IAO:0000112 "the role of subject in a clinical trial" xsd:string
property_value: IAO:0000112 "the student role" xsd:string
property_value: IAO:0000600 "b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/061-001"}
property_value: IAO:0000602 "(forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/061-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000030
name: object
namespace: bfo
is_a: BFO:0000040 ! material entity

[Term]
id: BFO:0000031
name: generically dependent continuant
def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" [] {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"}
comment: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
is_a: BFO:0000002 ! continuant
relationship: part_of BFO:0000031 {all_only="true"} ! generically dependent continuant
property_value: BFO:0000179 "gdc" xsd:string
property_value: BFO:0000180 "GenericallyDependentContinuant" xsd:string
property_value: IAO:0000112 "The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity." xsd:string
property_value: IAO:0000112 "the pdf file on your laptop, the pdf file that is a copy thereof on my laptop" xsd:string
property_value: IAO:0000112 "the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule." xsd:string
property_value: IAO:0000602 "(iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/074-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000034
name: function
is_a: BFO:0000016 ! disposition
property_value: BFO:0000179 "function" xsd:string
property_value: BFO:0000180 "Function" xsd:string
property_value: editor_note "BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc." xsd:string
property_value: IAO:0000112 "the function of a hammer to drive in nails" xsd:string
property_value: IAO:0000112 "the function of a heart pacemaker to regulate the beating of a heart through electricity" xsd:string
property_value: IAO:0000112 "the function of amylase in saliva to break down starch into sugar" xsd:string
property_value: IAO:0000600 "A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/064-001"}
property_value: IAO:0000602 "(forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/064-001"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000040
name: material entity
namespace: bfo
def: "An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." []
is_a: BFO:0000004 ! independent continuant
disjoint_from: BFO:0000141 ! immaterial entity
property_value: BFO:0000179 "material" xsd:string
property_value: BFO:0000180 "MaterialEntity" xsd:string
property_value: editor_note "BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60" xsd:string
property_value: editor_note "BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity." xsd:string
property_value: editor_note "BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here." xsd:string
property_value: editor_note "Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time." xsd:string
property_value: IAO:0000112 "a flame" xsd:string
property_value: IAO:0000112 "a forest fire" xsd:string
property_value: IAO:0000112 "a human being" xsd:string
property_value: IAO:0000112 "a hurricane" xsd:string
property_value: IAO:0000112 "a photon" xsd:string
property_value: IAO:0000112 "a puff of smoke" xsd:string
property_value: IAO:0000112 "a sea wave" xsd:string
property_value: IAO:0000112 "a tornado" xsd:string
property_value: IAO:0000112 "an aggregate of human beings." xsd:string
property_value: IAO:0000112 "an energy wave" xsd:string
property_value: IAO:0000112 "an epidemic" xsd:string
property_value: IAO:0000112 "the undetached arm of a human being" xsd:string
property_value: IAO:0000600 "A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"}
property_value: IAO:0000601 "every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"}
property_value: IAO:0000601 "Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])" xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"}
property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/021-002"}
property_value: IAO:0000602 "(forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/020-002"}
property_value: IAO:0000602 "(forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002] " xsd:string {IAO:0010000="http://purl.obolibrary.org/obo/bfo/axiom/019-002"}
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BFO:0000141
name: immaterial entity
is_a: BFO:0000004 ! independent continuant
property_value: BFO:0000179 "immaterial" xsd:string
property_value: BFO:0000180 "ImmaterialEntity" xsd:string
property_value: editor_note "BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10" xsd:string
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl

[Term]
id: BSPO:0000000
name: left side
namespace: spatial
def: "The side of an organism that is left of the sagittal plane." [BSPO:cjm]
synonym: "left" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: left_of BSPO:0000007 ! right side
relationship: starts_axis BSPO:0000017 ! left-right axis

[Term]
id: BSPO:0000001
name: upper side
namespace: spatial
comment: Consider merging with superior side.
synonym: "upper" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: starts_axis BSPO:0000011 ! upper-lower axis

[Term]
id: BSPO:0000002
name: lower side
namespace: spatial
comment: Consider merging with inferior side.
synonym: "lower" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: finishes_axis BSPO:0000011 ! upper-lower axis

[Term]
id: BSPO:0000005
name: anatomical surface
namespace: spatial
def: "A 2D surface of an anatomical continuant." [BSPO:cjm]
comment: to be merged into CARO
synonym: "surface" EXACT []
xref: FMA:24137
is_a: CARO:0000010 ! anatomical boundary

[Term]
id: BSPO:0000006
name: anatomical margin
namespace: spatial
def: "Fiat anatomical region extending a short distance from the boundary of an object inwards." [BSPO:cjm]
synonym: "edge" EXACT []
synonym: "margin" EXACT []
is_a: BSPO:0000070 ! anatomical region

[Term]
id: BSPO:0000007
name: right side
namespace: spatial
def: "The side of an organism that is right of the sagittal plane." [BSPO:cjm, BSPO:wd]
synonym: "right" EXACT []
is_a: BSPO:0000054 ! anatomical side
relationship: finishes_axis BSPO:0000017 ! left-right axis

[Term]
id: BSPO:0000010
name: anatomical axis
namespace: spatial
def: "A straight line through space, intersecting an anatomical entity." [BSPO:cjm]
comment: Axis directions are defined in terms of axes.
xref: http://upload.wikimedia.org/wikipedia/commons/3/34/Anatomical_Directions_and_Axes.JPG
is_a: CARO:0000008 ! anatomical line
relationship: passes_through CARO:0000000 ! anatomical entity

[Term]
id: BSPO:0000011
name: upper-lower axis
namespace: spatial
def: "An anatomical axis determined by gravity." [BSPO:cjm]
synonym: "superior-inferior axis" RELATED []
is_a: BSPO:0000010 ! anatomical axis

[Term]
id: BSPO:0000013
name: anterior-posterior axis
namespace: spatial
def: "An axis that extends through an organism from head end to opposite end of body or tail." [BSPO:cjm]
comment: In sponges, AP is used to indicate the direction of movement [in larval stage] (as it is in other metazoans that move, e.g., the basal bilaterians). [PM]
synonym: "A-P axis" EXACT []
synonym: "anteroposterior axis" EXACT []
synonym: "AP axis" EXACT []
synonym: "cephalocaudal axis" NARROW [http://en.wikipedia.org/wiki/Anatomical_terms_of_location]
synonym: "craniocaudal axis" NARROW vertebrate []
synonym: "longitudinal axis" RELATED []
synonym: "rostral/caudal" NARROW vertebrate []
synonym: "rostrocaudal axis" NARROW vertebrate []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000018 ! transverse plane
relationship: approximately_perpendicular_to BSPO:0000016 ! dorsal-ventral axis
relationship: orthogonal_to BSPO:0000018 ! transverse plane

[Term]
id: BSPO:0000015
name: proximal-distal axis
namespace: spatial
def: "An axis that extends from the point of attachment of a structure (proximal) to the  point furthest away from the plane of attachment (distal)." [BSPO:curators, http://en.wikipedia.org/wiki/Anatomical_terms_of_location]
comment: In some communities, proximal and distal are used when specifying the position of parts of elements that are contained within the body, such as gill arches or vertebral spines. In these cases, use of the classes medial-lateral axis or medial-external axis are more appropriate.
synonym: "proximal/distal" EXACT []
synonym: "proximodistal" EXACT []
is_a: BSPO:0000010 ! anatomical axis

[Term]
id: BSPO:0000016
name: dorsal-ventral axis
namespace: spatial
def: "An axis that is approximately perpendicular to the anterior-posterior axis and that extends through the horizontal plane of the body." [BSPO:curators]
synonym: "anterior-posterior axis" NARROW human []
synonym: "D-V axis" EXACT []
synonym: "dorsoventral axis" EXACT []
synonym: "DV axis" EXACT []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000019 ! horizontal plane
relationship: orthogonal_to BSPO:0000019 ! horizontal plane

[Term]
id: BSPO:0000017
name: left-right axis
namespace: spatial
def: "An axis that bisects an organism from left to right sides of body, through a sagittal plane." [BSPO:cjm]
synonym: "dextro-sinister axis" EXACT []
synonym: "L-R axis" EXACT []
synonym: "left to right axis" EXACT []
synonym: "LR axis" EXACT []
synonym: "R-L axis" EXACT []
synonym: "right to left axis" EXACT []
synonym: "right-left axis" EXACT []
synonym: "RL axis" EXACT []
is_a: BSPO:0000010 ! anatomical axis
intersection_of: BSPO:0000010 ! anatomical axis
intersection_of: orthogonal_to BSPO:0000417 ! sagittal plane
relationship: orthogonal_to BSPO:0000417 ! sagittal plane

[Term]
id: BSPO:0000018
name: transverse plane
namespace: spatial
def: "Anatomical plane that divides body into anterior and posterior parts." [BSPO:mah]
synonym: "axial plane" EXACT []
synonym: "axial section" EXACT []
synonym: "cross-section" RELATED []
synonym: "transverse section" EXACT []
xref: FMA:12247
is_a: BSPO:0000400 ! anatomical plane

[Term]
id: BSPO:0000019
name: horizontal plane
namespace: spatial
def: "Anatomical plane that divides bilateral body into dorsal and ventral parts." [BSPO:mah]
synonym: "coronal section" RELATED []
synonym: "frontal plane" EXACT []
synonym: "frontal section" RELATED []
synonym: "horizontal anatomical plane" EXACT [FMA:52810]
synonym: "horizontal section" EXACT []
xref: FMA:52810
is_a: BSPO:0000400 ! anatomical plane

[Term]
id: BSPO:0000026
name: antero-dorsal region
namespace: spatial
def: "Anatomical region that overlaps the anterior and dorsal regions of a body or body part." [BSPO:wd]
synonym: "anterodorsal region " EXACT []
is_a: BSPO:0000071 ! anterior region
is_a: BSPO:0000079 ! dorsal region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000063 ! dorsal side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:01:38Z

[Term]
id: BSPO:0000027
name: antero-ventral region
namespace: spatial
def: "Anatomical region that overlaps the anterior and ventral regions of a body or body part." [BSPO:wd]
synonym: "anteroventral region " EXACT []
is_a: BSPO:0000071 ! anterior region
is_a: BSPO:0000084 ! ventral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000068 ! ventral side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:04:59Z

[Term]
id: BSPO:0000028
name: postero-lateral region
namespace: spatial
def: "Anatomical region that overlaps the posterior and lateral regions of the body or body part." [BSPO:wd]
synonym: "posterolateral region" EXACT []
is_a: BSPO:0000072 ! posterior region
is_a: BSPO:0000082 ! lateral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000066 ! lateral side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:06:01Z

[Term]
id: BSPO:0000029
name: antero-lateral region
namespace: spatial
def: "Anatomical region that overlaps the anterior and lateral regions of a body or body part." [BSPO:wd]
synonym: "anterolateral region" EXACT []
is_a: BSPO:0000071 ! anterior region
is_a: BSPO:0000082 ! lateral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000066 ! lateral side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:07:18Z

[Term]
id: BSPO:0000030
name: postero-dorsal region
namespace: spatial
def: "Anatomical region that overlaps the posterior and dorsal regions of the body or body part." [BSPO:wd]
synonym: "posterodorsal region" EXACT []
is_a: BSPO:0000072 ! posterior region
is_a: BSPO:0000079 ! dorsal region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000063 ! dorsal side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:08:13Z

[Term]
id: BSPO:0000031
name: upper region
namespace: spatial
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000001 ! upper side
relationship: overlaps BSPO:0000001 ! upper side

[Term]
id: BSPO:0000032
name: lower region
namespace: spatial
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000002 ! lower side
relationship: overlaps BSPO:0000002 ! lower side

[Term]
id: BSPO:0000035
name: postero-ventral region
namespace: spatial
def: "Anatomical region that overlaps the posterior and ventral regions of a body or body part." [BSPO:wd]
synonym: "posteroventral region" EXACT []
is_a: BSPO:0000072 ! posterior region
is_a: BSPO:0000084 ! ventral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000068 ! ventral side
created_by: Melissa  Haendel
creation_date: 2009-06-15T01:08:38Z

[Term]
id: BSPO:0000042
name: antero-medial margin
namespace: spatial
def: "Anatomical margin that is located on the antero-medial region of the body or body part." [BSPO:wd]
synonym: "anteromedial margin" EXACT []
is_a: BSPO:0000050 ! antero-medial region
is_a: BSPO:0000671 ! anterior margin
is_a: BSPO:0000683 ! medial margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:49:57Z

[Term]
id: BSPO:0000045
name: antero-lateral margin
namespace: spatial
def: "Anatomical margin that is located on the antero-lateral region of the body or body part." [BSPO:wd]
synonym: "anterolateral margin" EXACT []
is_a: BSPO:0000029 ! antero-lateral region
is_a: BSPO:0000671 ! anterior margin
is_a: BSPO:0000682 ! lateral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000066 ! lateral side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:50:37Z

[Term]
id: BSPO:0000046
name: postero-medial margin
namespace: spatial
def: "Anatomical margin that is located on the postero-medial region of the body or body part." [BSPO:wd]
synonym: "posteromedial margin" EXACT []
is_a: BSPO:0000064 ! postero-medial region
is_a: BSPO:0000672 ! posterior margin
is_a: BSPO:0000683 ! medial margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:51:07Z

[Term]
id: BSPO:0000047
name: postero-lateral margin
namespace: spatial
def: "Anatomical margin that is located on the postero-lateral region of the body or body part." [BSPO:wd]
synonym: "posterolateral margin" EXACT []
is_a: BSPO:0000028 ! postero-lateral region
is_a: BSPO:0000672 ! posterior margin
is_a: BSPO:0000682 ! lateral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000066 ! lateral side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:51:42Z

[Term]
id: BSPO:0000048
name: dorso-medial margin
namespace: spatial
def: "Anatomical margin that is located on the dorso-medial region of the body or body part." [BSPO:wd]
synonym: "dorso-medial margin" EXACT []
is_a: BSPO:0000069 ! dorso-medial region
is_a: BSPO:0000679 ! dorsal margin
is_a: BSPO:0000683 ! medial margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000063 ! dorsal side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:52:04Z

[Term]
id: BSPO:0000049
name: ventro-medial margin
namespace: spatial
def: "Anatomical margin that is located on the ventro-medial region of the body or body part." [BSPO:wd]
synonym: "ventromedial margin" EXACT []
is_a: BSPO:0000112 ! ventro-medial region
is_a: BSPO:0000683 ! medial margin
is_a: BSPO:0000684 ! ventral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000067 ! medial side
intersection_of: overlaps BSPO:0000068 ! ventral side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:52:48Z

[Term]
id: BSPO:0000050
name: antero-medial region
namespace: spatial
def: "Anatomical region that overlaps the anterior and medial regions of the body or body part." [BSPO:wd]
synonym: "anteromedial region" EXACT []
is_a: BSPO:0000071 ! anterior region
is_a: BSPO:0000083 ! medial region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:55:32Z

[Term]
id: BSPO:0000054
name: anatomical side
namespace: spatial
def: "An anatomical region bounded by a plane perpendicular to an axis through the middle." [BSPO:cjm]
xref: FBql:00005841
is_a: BSPO:0000070 ! anatomical region

[Term]
id: BSPO:0000055
name: anterior side
namespace: spatial
def: "An anatomical region that is the entire part of an anatomical structure anterior to a transverse plane and bounded on one side by the same transverse plane." [BSPO:RW]
synonym: "anterior" EXACT []
synonym: "rostral" EXACT []
xref: FBcv:0000053
xref: FBql:00005848
is_a: BSPO:0000054 ! anatomical side
relationship: anterior_to BSPO:0000056 ! posterior side
relationship: opposite_to BSPO:0000056 ! posterior side
relationship: starts_axis BSPO:0000013 ! anterior-posterior axis

[Term]
id: BSPO:0000056
name: posterior side
namespace: spatial
def: "An anatomical region that is the entire part of an anatomical structure posterior to a transverse plane and bounded on one side by the same transverse plane." [BSPO:RW, BSPO:wd]
synonym: "caudal" NARROW vertebrate []
synonym: "posterior" EXACT []
xref: FBcv:0000065
xref: FBql:00005849
is_a: BSPO:0000054 ! anatomical side
relationship: finishes_axis BSPO:0000013 ! anterior-posterior axis
relationship: posterior_to BSPO:0000055 ! anterior side

[Term]
id: BSPO:0000061
name: proximal side
namespace: spatial
synonym: "proximal" EXACT []
xref: FBcv:0000066
xref: FBql:00005852
is_a: BSPO:0000054 ! anatomical side
relationship: opposite_to BSPO:0000062 ! distal side
relationship: starts_axis BSPO:0000015 ! proximal-distal axis

[Term]
id: BSPO:0000062
name: distal side
namespace: spatial
def: "Anatomical side that is distally located on an organism or structure." [BSPO:wd]
synonym: "distal" EXACT []
xref: FBcv:0000058
xref: FBql:00005853
is_a: BSPO:0000054 ! anatomical side
relationship: distal_to BSPO:0000061 ! proximal side
relationship: finishes_axis BSPO:0000015 ! proximal-distal axis

[Term]
id: BSPO:0000063
name: dorsal side
namespace: spatial
def: "An anatomical region that is the entire part of an anatomical structure dorsal to a horizontal plane and bounded on one side by the same transverse plane." [BSPO:wd]
synonym: "dorsal" EXACT []
xref: FBcv:0000059
xref: FBql:00005842
is_a: BSPO:0000054 ! anatomical side
relationship: dorsal_to BSPO:0000066 ! lateral side
relationship: opposite_to BSPO:0000068 ! ventral side
relationship: starts_axis BSPO:0000016 ! dorsal-ventral axis

[Term]
id: BSPO:0000064
name: postero-medial region
namespace: spatial
def: "Anatomical region that overlaps the posterior and medial regions of the body or body part." [BSPO:wd]
synonym: "posteromedial region" EXACT []
is_a: BSPO:0000072 ! posterior region
is_a: BSPO:0000083 ! medial region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:56:39Z

[Term]
id: BSPO:0000066
name: lateral side
namespace: spatial
synonym: "lateral" EXACT []
xref: FBcv:0000063
xref: FBql:00005844
is_a: BSPO:0000054 ! anatomical side

[Term]
id: BSPO:0000067
name: medial side
namespace: spatial
comment: a point in the centre of the organism (where the left-right axis intersects the midsagittal plane)
synonym: "medial" EXACT []
xref: FBcv:0000064
xref: FBql:00005847
is_a: BSPO:0000054 ! anatomical side

[Term]
id: BSPO:0000068
name: ventral side
namespace: spatial
def: "An anatomical region that is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane." [BSPO:RW, BSPO:wd]
synonym: "ventral" EXACT []
xref: FBcv:0000070
xref: FBql:00005843
is_a: BSPO:0000054 ! anatomical side
relationship: finishes_axis BSPO:0000016 ! dorsal-ventral axis

[Term]
id: BSPO:0000069
name: dorso-medial region
namespace: spatial
def: "Anatomical region that overlaps the dorsal and medial regions of the body or body part." [BSPO:wd]
synonym: "dorsomedial region" EXACT []
is_a: BSPO:0000079 ! dorsal region
is_a: BSPO:0000083 ! medial region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000063 ! dorsal side
intersection_of: overlaps BSPO:0000067 ! medial side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:57:22Z

[Term]
id: BSPO:0000070
name: anatomical region
namespace: spatial
def: "A 3D region in space without well-defined compartmental boundaries; for example, the dorsal region of an ectoderm." [BSPO:cjm]
comment: to be merged into CARO
xref: FBql:00005841
is_a: CARO:0000003 ! connected anatomical structure

[Term]
id: BSPO:0000071
name: anterior region
namespace: spatial
def: "Anatomical region anteriorly located on the body or body part." [BSPO:wd]
xref: FBql:00005848
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000055 ! anterior side
relationship: overlaps BSPO:0000055 ! anterior side

[Term]
id: BSPO:0000072
name: posterior region
namespace: spatial
def: "Anatomical region posteriorly located on the body or body part." [BSPO:wd]
xref: FBql:00005849
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000056 ! posterior side
relationship: overlaps BSPO:0000056 ! posterior side

[Term]
id: BSPO:0000077
name: proximal region
namespace: spatial
def: "Anatomical region proximally located on the body or body part." [BSPO:wd]
xref: FBql:00005852
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000061 ! proximal side
relationship: overlaps BSPO:0000061 ! proximal side

[Term]
id: BSPO:0000078
name: distal region
namespace: spatial
def: "Anatomical region distally located on the body or body part." [BSPO:wd]
xref: FBql:00005853
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000062 ! distal side
relationship: overlaps BSPO:0000062 ! distal side

[Term]
id: BSPO:0000079
name: dorsal region
namespace: spatial
def: "Anatomical region dorsally located on the body or body part." [BSPO:wd]
xref: FBql:00005842
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000063 ! dorsal side
relationship: overlaps BSPO:0000063 ! dorsal side

[Term]
id: BSPO:0000080
name: dorso-lateral region
namespace: spatial
def: "Anatomical region that overlaps the dorsal and lateral regions of a body or body part." [BSPO:wd]
synonym: "dorsolateral region" EXACT []
xref: FBql:00005845
is_a: BSPO:0000079 ! dorsal region
is_a: BSPO:0000082 ! lateral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000063 ! dorsal side
intersection_of: overlaps BSPO:0000066 ! lateral side

[Term]
id: BSPO:0000082
name: lateral region
namespace: spatial
def: "Anatomical region laterally located on the body or body part." [BSPO:wd]
xref: FBql:00005844
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000066 ! lateral side
relationship: overlaps BSPO:0000066 ! lateral side

[Term]
id: BSPO:0000083
name: medial region
namespace: spatial
def: "Anatomical region medially located on the body or body part." [BSPO:wd]
xref: FBql:00005847
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000067 ! medial side
relationship: overlaps BSPO:0000067 ! medial side

[Term]
id: BSPO:0000084
name: ventral region
namespace: spatial
def: "Anatomical region ventrally located on the body or body part." [BSPO:wd]
xref: FBql:00005843
is_a: BSPO:0000070 ! anatomical region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000068 ! ventral side
relationship: overlaps BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000085
name: ventro-lateral region
namespace: spatial
def: "Anatomical region that overlaps the ventral and lateral regions of a body or body part." [BSPO:wd]
comment: This is an example of a composition of two axis positions.
synonym: "ventrolateral region" EXACT []
xref: FBql:00005846
is_a: BSPO:0000082 ! lateral region
is_a: BSPO:0000084 ! ventral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000066 ! lateral side
intersection_of: overlaps BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000112
name: ventro-medial region
namespace: spatial
def: "The region corresponding to the ventral region of the entity, towards the midline." [BSPO:wd]
synonym: "medioventral region" EXACT []
synonym: "ventromedial region" EXACT []
is_a: BSPO:0000083 ! medial region
is_a: BSPO:0000084 ! ventral region
intersection_of: BSPO:0000070 ! anatomical region
intersection_of: overlaps BSPO:0000067 ! medial side
intersection_of: overlaps BSPO:0000068 ! ventral side
created_by: Melissa  Haendel
creation_date: 2009-09-10T08:57:54Z

[Term]
id: BSPO:0000371
name: anterior surface
namespace: spatial
def: "Anatomical surface that is located on the anterior side of the body or body part." [BSPO:wd]
xref: FBql:00005848
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000055 ! anterior side
relationship: surface_of BSPO:0000055 ! anterior side

[Term]
id: BSPO:0000372
name: posterior surface
namespace: spatial
def: "Anatomical surface that is located on the posterior side of the body or body part." [BSPO:wd]
xref: FBql:00005849
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000056 ! posterior side
relationship: surface_of BSPO:0000056 ! posterior side

[Term]
id: BSPO:0000377
name: internal side
name: proximal surface
namespace: spatial
def: "Anatomical surface that is located on the proximal side of the body or body part." [BSPO:wd]
xref: FBql:00005852
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000061 ! proximal side
relationship: opposite_to BSPO:0000378 ! distal surface
relationship: surface_of BSPO:0000061 ! proximal side

[Term]
id: BSPO:0000378
name: distal surface
name: external side
namespace: spatial
def: "Anatomical surface that is located on the distal side of the body or body part." [BSPO:wd]
xref: FBql:00005853
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000062 ! distal side
relationship: opposite_to BSPO:0000377 ! internal side
relationship: surface_of BSPO:0000062 ! distal side

[Term]
id: BSPO:0000379
name: dorsal surface
namespace: spatial
def: "Anatomical surface that located on the dorsal side of the body or body part." [BSPO:wd]
xref: FBql:00005842
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000063 ! dorsal side
relationship: surface_of BSPO:0000063 ! dorsal side

[Term]
id: BSPO:0000382
name: lateral surface
namespace: spatial
def: "Anatomical surface that located on the lateral side of the body or body part." [BSPO:wd]
xref: FBql:00005844
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000066 ! lateral side
relationship: surface_of BSPO:0000066 ! lateral side

[Term]
id: BSPO:0000383
name: medial surface
namespace: spatial
def: "Anatomical surface that located on the medial side of the body or body part." [BSPO:wd]
xref: FBql:00005847
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000067 ! medial side
relationship: surface_of BSPO:0000067 ! medial side

[Term]
id: BSPO:0000384
name: ventral surface
namespace: spatial
def: "Anatomical surface that is located on the ventral side of the body or body part." [BSPO:wd]
xref: FBql:00005843
is_a: BSPO:0000005 ! anatomical surface
intersection_of: BSPO:0000005 ! anatomical surface
intersection_of: surface_of BSPO:0000068 ! ventral side
relationship: surface_of BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000400
name: anatomical plane
namespace: spatial
def: "A flat 2D plane intersecting an anatomical continuant, dividing it into two adjacent portions." [BSPO:cjm]
comment: These anatomical sections are applicable to most bilaterally symmetrical animals, but bipedal animals such as humans have more complex usage of these terms. For example, in post-embryonic humans a coronal plane is vertical and a transverse plane is horizontal, but for embryos and quadrupeds a coronal plane is horizontal and a transverse plane is vertical.
synonym: "anatomical cross-section" EXACT []
synonym: "anatomical section" EXACT []
synonym: "cross-section" RELATED []
synonym: "plane" EXACT []
synonym: "section" EXACT []
xref: FMA:242982
is_a: CARO:0000010 ! anatomical boundary

[Term]
id: BSPO:0000417
name: sagittal plane
namespace: spatial
def: "Anatomical plane that divides a bilateral body into left and right parts, not necessarily of even size." [BSPO:cjm, BSPO:DOS, BSPO:mah]
synonym: "left/right plane" EXACT []
synonym: "median plane" EXACT []
synonym: "sagittal section" EXACT []
xref: FMA:11361
is_a: BSPO:0000010 ! anatomical axis
is_a: BSPO:0000400 ! anatomical plane
intersection_of: BSPO:0000400 ! anatomical plane
intersection_of: BSPO:0001102 BSPO:0000013 ! parallel to anterior-posterior axis
intersection_of: BSPO:0001102 BSPO:0000016 ! parallel to dorsal-ventral axis
intersection_of: orthogonal_to BSPO:0000017 ! left-right axis
relationship: BSPO:0001102 BSPO:0000013 ! parallel to anterior-posterior axis
relationship: BSPO:0001102 BSPO:0000016 ! parallel to dorsal-ventral axis
relationship: orthogonal_to BSPO:0000017 ! left-right axis

[Term]
id: BSPO:0000671
name: anterior margin
namespace: spatial
def: "Anatomical margin that is located on the anterior side of a body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000071 ! anterior region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000055 ! anterior side

[Term]
id: BSPO:0000672
name: posterior margin
namespace: spatial
def: "Anatomical margin that is located on the posterior side of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000072 ! posterior region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000056 ! posterior side

[Term]
id: BSPO:0000677
name: proximal margin
namespace: spatial
def: "Anatomical margin that is located on the proximal region of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000077 ! proximal region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000061 ! proximal side

[Term]
id: BSPO:0000678
name: distal margin
namespace: spatial
def: "Anatomical margin that is located on the distal side of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000078 ! distal region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000062 ! distal side

[Term]
id: BSPO:0000679
name: dorsal margin
namespace: spatial
def: "Anatomical margin that is located on the dorsal side of body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000079 ! dorsal region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000063 ! dorsal side

[Term]
id: BSPO:0000680
name: dorso-lateral margin
namespace: spatial
def: "Anatomical margin that is located on the dorso-lateral region of the body or body part." [BSPO:wd]
synonym: "dorsolateral margin" EXACT []
is_a: BSPO:0000080 ! dorso-lateral region
is_a: BSPO:0000679 ! dorsal margin
is_a: BSPO:0000682 ! lateral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000063 ! dorsal side
intersection_of: overlaps BSPO:0000066 ! lateral side

[Term]
id: BSPO:0000682
name: lateral margin
namespace: spatial
def: "Anatomical margin that is located on the lateral side of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000082 ! lateral region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000066 ! lateral side

[Term]
id: BSPO:0000683
name: medial margin
namespace: spatial
def: "Anatomical margin that is located on the medial side of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000083 ! medial region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000067 ! medial side

[Term]
id: BSPO:0000684
name: ventral margin
namespace: spatial
def: "Anatomical margin that is located on the ventral side of the body or body part." [BSPO:wd]
is_a: BSPO:0000006 ! anatomical margin
is_a: BSPO:0000084 ! ventral region
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000685
name: ventro-lateral margin
namespace: spatial
def: "Anatomical margin that is located on the ventro-lateral region of the body or body part." [BSPO:wd]
comment: This is an example of a composition of two axis positions
synonym: "ventrolateral margin" EXACT []
is_a: BSPO:0000085 ! ventro-lateral region
is_a: BSPO:0000682 ! lateral margin
is_a: BSPO:0000684 ! ventral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000066 ! lateral side
intersection_of: overlaps BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000686
name: antero-dorsal margin
namespace: spatial
def: "Anatomical margin that is located on the antero-dorso region of the body or body part." [BSPO:wd]
synonym: "anterodorsal margin" EXACT []
is_a: BSPO:0000026 ! antero-dorsal region
is_a: BSPO:0000671 ! anterior margin
is_a: BSPO:0000679 ! dorsal margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000063 ! dorsal side

[Term]
id: BSPO:0000687
name: postero-dorsal margin
namespace: spatial
def: "Anatomical margin that is located on the postero-dorsal region of the body or body part." [BSPO:wd]
synonym: "posterodorsal margin" EXACT []
is_a: BSPO:0000030 ! postero-dorsal region
is_a: BSPO:0000672 ! posterior margin
is_a: BSPO:0000679 ! dorsal margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000063 ! dorsal side

[Term]
id: BSPO:0000688
name: antero-ventral margin
namespace: spatial
def: "Anatomical margin that is located on the antero-ventral region of the body or body part." [BSPO:wd]
synonym: "anteroventral margin" EXACT []
is_a: BSPO:0000027 ! antero-ventral region
is_a: BSPO:0000671 ! anterior margin
is_a: BSPO:0000684 ! ventral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000055 ! anterior side
intersection_of: overlaps BSPO:0000068 ! ventral side

[Term]
id: BSPO:0000689
name: postero-ventral margin
namespace: spatial
def: "Anatomical margin that is located on the postero-ventral region of the body or body part." [BSPO:wd]
synonym: "posteroventral margin" EXACT []
is_a: BSPO:0000035 ! postero-ventral region
is_a: BSPO:0000672 ! posterior margin
is_a: BSPO:0000684 ! ventral margin
intersection_of: BSPO:0000006 ! anatomical margin
intersection_of: overlaps BSPO:0000056 ! posterior side
intersection_of: overlaps BSPO:0000068 ! ventral side

[Term]
id: CARO:0000000
name: anatomical entity
namespace: spatial
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex.  Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [CAROC:Brownsville2014]
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [CARO:MAH]
comment: Following BFO, material anatomical entities may have immaterial parts (the lumen of your stomach is part of your stomach).  The granularity limit follows the limits set by the Gene Ontology on the granularity limit for GO:cellular_component. Note that substances produced by an organism (sweat, feaces, urine) do not need to be part of an organism to qualify as an anatomical structure.
is_a: BFO:0000004 ! independent continuant

[Term]
id: CARO:0000003
name: anatomical structure
name: connected anatomical structure
namespace: spatial
def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CC:DOS]
comment: Note that the definition does not say 'generated exclusively by the co-ordinated expression of the organism's own genome', so this is still valid for cases where normal morphogenesis requires the actions of a facultative symbiont, or some looser dependency such as the a requirement for the presence of gut flora for normal gut development.
is_a: CARO:0000006 ! material anatomical entity

[Term]
id: CARO:0000006
name: material anatomical entity
namespace: spatial
def: "An anatomical entity that has mass." [CC:DOS]
is_a: CARO:0000000 ! anatomical entity
disjoint_from: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000007
name: immaterial anatomical entity
namespace: spatial
def: "An anatomical entity that has no mass." [CC:DOS]
def: "Anatomical entity that has no mass." []
is_a: BFO:0000141 ! immaterial entity
is_a: CARO:0000000 ! anatomical entity

[Term]
id: CARO:0000008
name: anatomical line
namespace: spatial
def: "A one dimensional, immaterial anatomical entity." [CC:DOS]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CARO:0000010
name: anatomical boundary
namespace: spatial
def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CC:DOS]
is_a: CARO:0000007 ! immaterial anatomical entity

[Term]
id: CHEBI:10545
name: electron
namespace: chebi_ontology
def: "Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV." []
subset: 3_STAR
synonym: "beta" RELATED [IUPAC]
synonym: "beta(-)" RELATED [ChEBI]
synonym: "beta-particle" RELATED [IUPAC]
synonym: "e" RELATED [IUPAC]
synonym: "e(-)" RELATED [UniProt]
synonym: "e-" RELATED [KEGG_COMPOUND]
synonym: "electron" EXACT [KEGG_COMPOUND]
synonym: "electron" EXACT IUPAC_NAME [IUPAC]
synonym: "electron" EXACT [ChEBI]
synonym: "Elektron" RELATED [ChEBI]
synonym: "negatron" RELATED [IUPAC]
xref: KEGG:C05359
xref: PMID:21614077 {source="Europe PMC"}
xref: Wikipedia:Electron
is_a: CHEBI:36338 ! lepton
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.000548579903" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string

[Term]
id: CHEBI:131927
name: dicarboxylic acids and O-substituted derivatives
namespace: chebi_ontology
def: "A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens." []
subset: 3_STAR
synonym: "dicarboxylic acids and derivatives" RELATED [ChEBI]
is_a: CHEBI:36586 ! carbonyl compound

[Term]
id: CHEBI:132153
name: hyaluronate
namespace: chebi_ontology
def: "A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3." []
subset: 3_STAR
synonym: "hyaluronan" RELATED [UniProt]
synonym: "hyaluronate polyanion" RELATED [ChEBI]
is_a: CHEBI:61469 ! polyanionic polymer
is_a: CHEBI:63551 ! carbohydrate acid derivative anion
relationship: is_conjugate_base_of CHEBI:16336 ! hyaluronic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C14H20NO11)n.H2O" xsd:string

[Term]
id: CHEBI:136889
name: 5beta steroid
namespace: chebi_ontology
def: "Any steroid that has beta-configuration at position 5." []
subset: 3_STAR
synonym: "5beta steroids" RELATED [ChEBI]
synonym: "5beta-steroid" RELATED [ChEBI]
synonym: "5beta-steroids" RELATED [ChEBI]
is_a: CHEBI:35341 ! steroid

[Term]
id: CHEBI:138103
name: inorganic acid
namespace: chebi_ontology
def: "A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water." []
subset: 3_STAR
synonym: "inorganic acids" RELATED [ChEBI]
synonym: "mineral acid" RELATED [ChEBI]
synonym: "mineral acids" RELATED [ChEBI]
xref: Wikipedia:Mineral_acid
is_a: CHEBI:39141 ! Bronsted acid

[Term]
id: CHEBI:138366
name: bile acids
namespace: chebi_ontology
def: "Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration." []
subset: 3_STAR
is_a: CHEBI:25384 ! monocarboxylic acid
is_a: CHEBI:35350 ! hydroxy steroid
is_a: CHEBI:36078 ! cholanoid

[Term]
id: CHEBI:138675
name: gas molecular entity
namespace: chebi_ontology
def: "Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa)." []
subset: 3_STAR
synonym: "gas molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entities" RELATED [ChEBI]
synonym: "gaseous molecular entity" RELATED [ChEBI]
xref: Wikipedia:https\://en.wikipedia.org/wiki/Gas
is_a: CHEBI:33579 ! main group molecular entity

[Term]
id: CHEBI:13941
name: carbamate
namespace: chebi_ontology
subset: 3_STAR
synonym: "Carbamat" RELATED [ChEBI]
synonym: "carbamate" EXACT [UniProt]
synonym: "carbamate" EXACT IUPAC_NAME [IUPAC]
synonym: "carbamate ion" RELATED [ChemIDplus]
synonym: "carbamic acid, ion(1-)" RELATED [ChemIDplus]
synonym: "Karbamat" RELATED [ChEBI]
xref: Beilstein:3903503 {source="Beilstein"}
xref: CAS:302-11-4 {source="ChemIDplus"}
xref: Gmelin:239604 {source="Gmelin"}
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:28616 ! carbamic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.03212" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.00910" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([O-])=O" xsd:string

[Term]
id: CHEBI:142163
name: 24G7 epitope
namespace: chebi_ontology
def: "An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22." []
subset: 3_STAR
is_a: CHEBI:24433 ! group
relationship: has_role CHEBI:53000 ! epitope
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H6N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "134.136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "134.04801" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C(=CC(NC(=*)*)=*)(NC(C(C)=*)=O)*" xsd:string

[Term]
id: CHEBI:15339
name: acceptor
namespace: chebi_ontology
alt_id: CHEBI:13699
alt_id: CHEBI:2377
def: "A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity." []
subset: 3_STAR
synonym: "A" RELATED [KEGG_COMPOUND]
synonym: "accepteur" RELATED [ChEBI]
synonym: "Acceptor" EXACT [KEGG_COMPOUND]
synonym: "Akzeptor" RELATED [ChEBI]
synonym: "Hydrogen-acceptor" RELATED [KEGG_COMPOUND]
synonym: "Oxidized donor" RELATED [KEGG_COMPOUND]
xref: KEGG:C00028
xref: KEGG:C16722
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:15355
name: acetylcholine
namespace: chebi_ontology
alt_id: CHEBI:12686
alt_id: CHEBI:13715
alt_id: CHEBI:22197
alt_id: CHEBI:2416
alt_id: CHEBI:40559
def: "Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter." []
subset: 3_STAR
synonym: "2-acetyloxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC]
synonym: "ACETYLCHOLINE" EXACT [PDBeChem]
synonym: "Acetylcholine" EXACT [KEGG_COMPOUND]
synonym: "acetylcholine" EXACT [UniProt]
synonym: "ACh" RELATED [ChemIDplus]
synonym: "Azetylcholin" RELATED [ChEBI]
synonym: "choline acetate" RELATED [ChemIDplus]
synonym: "O-Acetylcholine" RELATED [KEGG_COMPOUND]
xref: Beilstein:1764436 {source="ChemIDplus"}
xref: CAS:51-84-3 {source="KEGG COMPOUND"}
xref: CAS:51-84-3 {source="ChemIDplus"}
xref: Drug_Central:65 {source="DrugCentral"}
xref: DrugBank:DB03128
xref: Gmelin:326108 {source="Gmelin"}
xref: KEGG:C01996
xref: LINCS:LSM-5888
xref: PDBeChem:ACH
xref: PMID:14764638 {source="Europe PMC"}
xref: PMID:15014918 {source="Europe PMC"}
xref: PMID:15231705 {source="Europe PMC"}
xref: PMID:15361288 {source="Europe PMC"}
xref: PMID:18050502 {source="Europe PMC"}
xref: PMID:18407448 {source="Europe PMC"}
xref: PMID:19255787 {source="Europe PMC"}
xref: PMID:20963497 {source="Europe PMC"}
xref: PMID:21130809 {source="Europe PMC"}
xref: PMID:21246223 {source="Europe PMC"}
xref: PMID:21545631 {source="Europe PMC"}
xref: PMID:21601579 {source="Europe PMC"}
xref: Wikipedia:Acetylcholine
is_a: CHEBI:35287 ! acylcholine
is_a: CHEBI:47622 ! acetate ester
relationship: has_role CHEBI:24621 ! hormone
relationship: has_role CHEBI:25512 ! neurotransmitter
relationship: has_role CHEBI:35620 ! vasodilator agent
relationship: has_role CHEBI:38325 ! muscarinic agonist
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:77746 ! human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C7H16NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OIPILFWXSMYKGL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "146.20748" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "146.11756" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)OCC[N+](C)(C)C" xsd:string

[Term]
id: CHEBI:15366
name: acetic acid
namespace: chebi_ontology
alt_id: CHEBI:22169
alt_id: CHEBI:2387
alt_id: CHEBI:40486
def: "A simple monocarboxylic acid containing two carbons." []
subset: 3_STAR
synonym: "ACETIC ACID" EXACT [PDBeChem]
synonym: "Acetic acid" EXACT [KEGG_COMPOUND]
synonym: "acetic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "acide acetique" RELATED [ChemIDplus]
synonym: "AcOH" RELATED [ChEBI]
synonym: "CH3-COOH" RELATED [IUPAC]
synonym: "CH3CO2H" RELATED [ChEBI]
synonym: "E 260" RELATED [ChEBI]
synonym: "E-260" RELATED [ChEBI]
synonym: "E260" RELATED [ChEBI]
synonym: "Essigsaeure" RELATED [ChEBI]
synonym: "Ethanoic acid" RELATED [KEGG_COMPOUND]
synonym: "ethoic acid" RELATED [ChEBI]
synonym: "Ethylic acid" RELATED [ChemIDplus]
synonym: "HOAc" RELATED [ChEBI]
synonym: "INS No. 260" RELATED [ChEBI]
synonym: "MeCO2H" RELATED [ChEBI]
synonym: "MeCOOH" RELATED [ChEBI]
synonym: "Methanecarboxylic acid" RELATED [ChemIDplus]
xref: Beilstein:506007 {source="Beilstein"}
xref: CAS:64-19-7 {source="ChemIDplus"}
xref: CAS:64-19-7 {source="NIST Chemistry WebBook"}
xref: CAS:64-19-7 {source="KEGG COMPOUND"}
xref: Drug_Central:4211 {source="DrugCentral"}
xref: Gmelin:1380 {source="Gmelin"}
xref: HMDB:HMDB0000042
xref: KEGG:C00033
xref: KEGG:D00010
xref: KNApSAcK:C00001176
xref: LIPID_MAPS_instance:LMFA01010002 {source="LIPID MAPS"}
xref: MetaCyc:ACET
xref: PDBeChem:ACT
xref: PDBeChem:ACY
xref: PMID:12005138 {source="Europe PMC"}
xref: PMID:15107950 {source="Europe PMC"}
xref: PMID:16630552 {source="Europe PMC"}
xref: PMID:16774200 {source="Europe PMC"}
xref: PMID:17190852 {source="Europe PMC"}
xref: PMID:19416101 {source="Europe PMC"}
xref: PMID:19469536 {source="Europe PMC"}
xref: PMID:22153255 {source="Europe PMC"}
xref: PMID:22173419 {source="Europe PMC"}
xref: PPDB:1333
xref: Reaxys:506007 {source="Reaxys"}
xref: Wikipedia:Acetic_acid
is_a: CHEBI:25384 ! monocarboxylic acid
relationship: has_role CHEBI:48356 ! protic solvent
relationship: has_role CHEBI:64049 ! food acidity regulator
relationship: has_role CHEBI:65256 ! antimicrobial food preservative
relationship: has_role CHEBI:83056 ! Daphnia magna metabolite
relationship: is_conjugate_acid_of CHEBI:30089 ! acetate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.05200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.02113" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(O)=O" xsd:string

[Term]
id: CHEBI:15379
name: dioxygen
namespace: chebi_ontology
alt_id: CHEBI:10745
alt_id: CHEBI:13416
alt_id: CHEBI:23833
alt_id: CHEBI:25366
alt_id: CHEBI:30491
alt_id: CHEBI:44742
alt_id: CHEBI:7860
subset: 3_STAR
synonym: "[OO]" RELATED [MolBase]
synonym: "dioxygen" EXACT IUPAC_NAME [IUPAC]
synonym: "dioxygene" RELATED [ChEBI]
synonym: "Disauerstoff" RELATED [ChEBI]
synonym: "E 948" RELATED [ChEBI]
synonym: "E-948" RELATED [ChEBI]
synonym: "E948" RELATED [ChEBI]
synonym: "molecular oxygen" RELATED [ChEBI]
synonym: "O2" RELATED [UniProt]
synonym: "O2" RELATED [IUPAC]
synonym: "O2" RELATED [KEGG_COMPOUND]
synonym: "Oxygen" RELATED [KEGG_COMPOUND]
synonym: "OXYGEN MOLECULE" RELATED [PDBeChem]
xref: CAS:7782-44-7 {source="NIST Chemistry WebBook"}
xref: CAS:7782-44-7 {source="ChemIDplus"}
xref: CAS:7782-44-7 {source="KEGG COMPOUND"}
xref: Gmelin:485 {source="Gmelin"}
xref: HMDB:HMDB0001377
xref: KEGG:C00007
xref: KEGG:D00003
xref: MetaCyc:OXYGEN-MOLECULE
xref: MolBase:750
xref: PDBeChem:OXY
xref: PMID:10906528 {source="Europe PMC"}
xref: PMID:16977326 {source="Europe PMC"}
xref: PMID:18210929 {source="Europe PMC"}
xref: PMID:18638417 {source="Europe PMC"}
xref: PMID:19840863 {source="Europe PMC"}
xref: PMID:7710549 {source="Europe PMC"}
xref: PMID:9463773 {source="Europe PMC"}
xref: Wikipedia:Oxygen
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:25362 ! elemental molecule
is_a: CHEBI:33263 ! diatomic oxygen
relationship: has_role CHEBI:27027 ! micronutrient
relationship: has_role CHEBI:33893 ! reagent
relationship: has_role CHEBI:35472 ! anti-inflammatory drug
relationship: has_role CHEBI:63248 ! oxidising agent
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: has_role CHEBI:77974 ! food packaging gas
relationship: is_conjugate_base_of CHEBI:29793 ! hydridodioxygen(1+)
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O2/c1-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYMOFIZGZYHOMD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "31.998" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=O" xsd:string

[Term]
id: CHEBI:15693
name: aldose
namespace: chebi_ontology
alt_id: CHEBI:13755
alt_id: CHEBI:22305
alt_id: CHEBI:2561
def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." []
subset: 3_STAR
synonym: "Aldose" EXACT [KEGG_COMPOUND]
synonym: "aldoses" RELATED [ChEBI]
synonym: "an aldose" RELATED [UniProt]
xref: KEGG:C01370
xref: Wikipedia:Aldose
is_a: CHEBI:35381 ! monosaccharide
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4O2(CH2O)n" xsd:string

[Term]
id: CHEBI:15841
name: polypeptide
namespace: chebi_ontology
alt_id: CHEBI:14860
alt_id: CHEBI:8314
def: "A peptide containing ten or more amino acid residues." []
subset: 3_STAR
synonym: "polipeptido" RELATED [ChEBI]
synonym: "Polypeptid" RELATED [ChEBI]
synonym: "Polypeptide" EXACT [KEGG_COMPOUND]
synonym: "polypeptides" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00403
is_a: CHEBI:16670 ! peptide
is_a: CHEBI:33839 ! macromolecule
property_value: http://purl.obolibrary.org/obo/chebi/formula "C4H6N2O3R2(C2H2NOR)n" xsd:string

[Term]
id: CHEBI:15986
name: polynucleotide
namespace: chebi_ontology
alt_id: CHEBI:13672
alt_id: CHEBI:14859
alt_id: CHEBI:8312
def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." []
subset: 3_STAR
synonym: "Polynucleotide" EXACT [KEGG_COMPOUND]
synonym: "polynucleotides" RELATED [ChEBI]
xref: KEGG:C00419
is_a: CHEBI:33695 ! information biomacromolecule
is_a: CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_part CHEBI:50319 ! nucleotide residue
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C5H8O6PR)n.C10H17O10PR2" xsd:string

[Term]
id: CHEBI:16134
name: ammonia
namespace: chebi_ontology
alt_id: CHEBI:13405
alt_id: CHEBI:13406
alt_id: CHEBI:13407
alt_id: CHEBI:13771
alt_id: CHEBI:22533
alt_id: CHEBI:44269
alt_id: CHEBI:44284
alt_id: CHEBI:44404
alt_id: CHEBI:7434
def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." []
subset: 3_STAR
synonym: "[NH3]" RELATED [MolBase]
synonym: "AMMONIA" EXACT [PDBeChem]
synonym: "Ammonia" EXACT [KEGG_COMPOUND]
synonym: "ammonia" EXACT IUPAC_NAME [IUPAC]
synonym: "ammoniac" RELATED [ChEBI]
synonym: "Ammoniak" RELATED [ChemIDplus]
synonym: "amoniaco" RELATED [ChEBI]
synonym: "azane" EXACT IUPAC_NAME [IUPAC]
synonym: "NH3" RELATED [KEGG_COMPOUND]
synonym: "NH3" RELATED [UniProt]
synonym: "NH3" RELATED [IUPAC]
synonym: "R-717" RELATED [ChEBI]
synonym: "spirit of hartshorn" RELATED [ChemIDplus]
xref: Beilstein:3587154 {source="Beilstein"}
xref: CAS:7664-41-7 {source="ChemIDplus"}
xref: CAS:7664-41-7 {source="NIST Chemistry WebBook"}
xref: CAS:7664-41-7 {source="KEGG COMPOUND"}
xref: Drug_Central:4625 {source="DrugCentral"}
xref: Gmelin:79 {source="Gmelin"}
xref: HMDB:HMDB0000051
xref: KEGG:C00014
xref: KEGG:D02916
xref: KNApSAcK:C00007267
xref: MetaCyc:AMMONIA
xref: MolBase:930
xref: PDBeChem:NH3
xref: PMID:110589 {source="Europe PMC"}
xref: PMID:11139349 {source="Europe PMC"}
xref: PMID:11540049 {source="Europe PMC"}
xref: PMID:11746427 {source="Europe PMC"}
xref: PMID:11783653 {source="Europe PMC"}
xref: PMID:13753780 {source="Europe PMC"}
xref: PMID:14663195 {source="Europe PMC"}
xref: PMID:15092448 {source="Europe PMC"}
xref: PMID:15094021 {source="Europe PMC"}
xref: PMID:15554424 {source="Europe PMC"}
xref: PMID:15969015 {source="Europe PMC"}
xref: PMID:16008360 {source="Europe PMC"}
xref: PMID:16050680 {source="Europe PMC"}
xref: PMID:16348008 {source="Europe PMC"}
xref: PMID:16349403 {source="Europe PMC"}
xref: PMID:16614889 {source="Europe PMC"}
xref: PMID:16664306 {source="Europe PMC"}
xref: PMID:16842901 {source="Europe PMC"}
xref: PMID:17025297 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17569513 {source="Europe PMC"}
xref: PMID:17737668 {source="Europe PMC"}
xref: PMID:18670398 {source="Europe PMC"}
xref: PMID:22002069 {source="Europe PMC"}
xref: PMID:22081570 {source="Europe PMC"}
xref: PMID:22088435 {source="Europe PMC"}
xref: PMID:22100291 {source="Europe PMC"}
xref: PMID:22130175 {source="Europe PMC"}
xref: PMID:22150211 {source="Europe PMC"}
xref: PMID:22240068 {source="Europe PMC"}
xref: PMID:22290316 {source="Europe PMC"}
xref: PMID:22342082 {source="Europe PMC"}
xref: PMID:22385337 {source="Europe PMC"}
xref: PMID:22443779 {source="Europe PMC"}
xref: PMID:22560242 {source="Europe PMC"}
xref: Reaxys:3587154 {source="Reaxys"}
xref: Wikipedia:Ammonia
is_a: CHEBI:138675 ! gas molecular entity
is_a: CHEBI:35107 ! azane
is_a: CHEBI:37176 ! mononuclear parent hydride
relationship: has_role CHEBI:50910 ! neurotoxin
relationship: has_role CHEBI:59740 ! nucleophilic reagent
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:77941 ! EC 3.5.1.4 (amidase) inhibitor
relationship: has_role CHEBI:78433 ! refrigerant
relationship: is_conjugate_acid_of CHEBI:29337 ! azanide
relationship: is_conjugate_base_of CHEBI:28938 ! ammonium
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H3N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.03056" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.02655" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]N([H])[H]" xsd:string

[Term]
id: CHEBI:16189
name: sulfate
namespace: chebi_ontology
alt_id: CHEBI:15135
alt_id: CHEBI:45687
alt_id: CHEBI:9335
def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." []
subset: 3_STAR
synonym: "[SO4](2-)" RELATED [IUPAC]
synonym: "SO4(2-)" RELATED [IUPAC]
synonym: "Sulfate" EXACT [KEGG_COMPOUND]
synonym: "sulfate" EXACT [UniProt]
synonym: "sulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "Sulfate anion(2-)" RELATED [HMDB]
synonym: "Sulfate dianion" RELATED [HMDB]
synonym: "SULFATE ION" RELATED [PDBeChem]
synonym: "Sulfate(2-)" RELATED [HMDB]
synonym: "Sulfuric acid ion(2-)" RELATED [HMDB]
synonym: "sulphate" RELATED [ChEBI]
synonym: "sulphate ion" RELATED [ChEBI]
synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3648446 {source="Beilstein"}
xref: CAS:14808-79-8 {source="ChemIDplus"}
xref: CAS:14808-79-8 {source="NIST Chemistry WebBook"}
xref: Gmelin:2120 {source="Gmelin"}
xref: HMDB:HMDB0001448
xref: KEGG:C00059
xref: KEGG:D05963
xref: MetaCyc:SULFATE
xref: PDBeChem:SO4
xref: PMID:11200094 {source="Europe PMC"}
xref: PMID:11452993 {source="Europe PMC"}
xref: PMID:11581495 {source="Europe PMC"}
xref: PMID:11798107 {source="Europe PMC"}
xref: PMID:12166931 {source="Europe PMC"}
xref: PMID:12668033 {source="Europe PMC"}
xref: PMID:14597181 {source="Europe PMC"}
xref: PMID:15093386 {source="Europe PMC"}
xref: PMID:15984785 {source="Europe PMC"}
xref: PMID:16186560 {source="Europe PMC"}
xref: PMID:16345535 {source="Europe PMC"}
xref: PMID:16347366 {source="Europe PMC"}
xref: PMID:16348007 {source="Europe PMC"}
xref: PMID:16483812 {source="Europe PMC"}
xref: PMID:16534979 {source="Europe PMC"}
xref: PMID:16656509 {source="Europe PMC"}
xref: PMID:16742508 {source="Europe PMC"}
xref: PMID:16742518 {source="Europe PMC"}
xref: PMID:17120760 {source="Europe PMC"}
xref: PMID:17420092 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17709180 {source="Europe PMC"}
xref: PMID:18398178 {source="Europe PMC"}
xref: PMID:18815700 {source="Europe PMC"}
xref: PMID:18846414 {source="Europe PMC"}
xref: PMID:19047345 {source="Europe PMC"}
xref: PMID:19244483 {source="Europe PMC"}
xref: PMID:19544990 {source="Europe PMC"}
xref: PMID:19628332 {source="Europe PMC"}
xref: PMID:19812358 {source="Europe PMC"}
xref: PMID:30398859 {source="Europe PMC"}
xref: Reaxys:3648446 {source="Reaxys"}
xref: Wikipedia:Sulfate
is_a: CHEBI:33482 ! sulfur oxoanion
is_a: CHEBI:48154 ! sulfur oxide
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: has_role CHEBI:23357 ! cofactor
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:45696 ! hydrogensulfate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06360" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95283" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:16336
name: hyaluronic acid
namespace: chebi_ontology
alt_id: CHEBI:14412
alt_id: CHEBI:24622
alt_id: CHEBI:24623
alt_id: CHEBI:5772
def: "A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells." []
subset: 3_STAR
synonym: "[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n" RELATED [ChEBI]
synonym: "[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n" RELATED [KEGG_COMPOUND]
synonym: "acide hyaluronique" RELATED [ChEBI]
synonym: "acido hialuronico" RELATED [ChEBI]
synonym: "hyaluronan" RELATED [ChEBI]
synonym: "Hyaluronic acid" EXACT [KEGG_COMPOUND]
synonym: "Hyaluronsaeure" RELATED [ChEBI]
xref: Beilstein:8538277 {source="Beilstein"}
xref: CAS:9004-61-9 {source="KEGG COMPOUND"}
xref: CAS:9004-61-9 {source="ChemIDplus"}
xref: HMDB:HMDB0010366
xref: KEGG:C00518
xref: KEGG:D08043
xref: KEGG:G10505
xref: PMID:11122186 {source="Europe PMC"}
xref: PMID:18056362 {source="Europe PMC"}
xref: PMID:18290544 {source="Europe PMC"}
xref: Reaxys:8187837 {source="Reaxys"}
xref: Wikipedia:Hyaluronan
is_a: CHEBI:37395 ! mucopolysaccharide
is_a: CHEBI:72813 ! exopolysaccharide
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:132153 ! hyaluronate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C14H21NO12)n" xsd:string

[Term]
id: CHEBI:16541
name: protein polypeptide chain
namespace: chebi_ontology
alt_id: CHEBI:8526
def: "A naturally occurring polypeptide synthesized at the ribosome." []
subset: 3_STAR
synonym: "a protein" RELATED [UniProt]
synonym: "polypeptide chain" RELATED [ChEBI]
synonym: "Protein" RELATED [KEGG_COMPOUND]
synonym: "protein polypeptide chains" RELATED [ChEBI]
xref: KEGG:C00017
is_a: CHEBI:15841 ! polypeptide
relationship: has_part CHEBI:33700 ! proteinogenic amino-acid residue

[Term]
id: CHEBI:16646
name: carbohydrate
namespace: chebi_ontology
alt_id: CHEBI:15131
alt_id: CHEBI:23008
alt_id: CHEBI:9318
def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." []
subset: 3_STAR
synonym: "a carbohydrate" RELATED [UniProt]
synonym: "carbohidrato" RELATED [IUPAC]
synonym: "carbohidratos" RELATED [IUPAC]
synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC]
synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC]
synonym: "glucide" RELATED [ChEBI]
synonym: "glucides" RELATED [ChEBI]
synonym: "glucido" RELATED [ChEBI]
synonym: "glucidos" RELATED [ChEBI]
synonym: "hydrates de carbone" RELATED [ChEBI]
synonym: "Kohlenhydrat" RELATED [ChEBI]
synonym: "Kohlenhydrate" RELATED [ChEBI]
synonym: "saccharide" RELATED [IUPAC]
synonym: "saccharides" RELATED [IUPAC]
synonym: "saccharidum" RELATED [ChEBI]
xref: Wikipedia:Carbohydrate
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16670
name: peptide
namespace: chebi_ontology
alt_id: CHEBI:14753
alt_id: CHEBI:25906
alt_id: CHEBI:7990
def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." []
subset: 3_STAR
synonym: "Peptid" RELATED [ChEBI]
synonym: "Peptide" EXACT [KEGG_COMPOUND]
synonym: "peptides" EXACT IUPAC_NAME [IUPAC]
synonym: "peptido" RELATED [ChEBI]
synonym: "peptidos" RELATED [ChEBI]
xref: KEGG:C00012
is_a: CHEBI:37622 ! carboxamide
is_a: CHEBI:50047 ! organic amino compound
relationship: has_part CHEBI:33708 ! amino-acid residue
relationship: is_tautomer_of CHEBI:60466 ! peptide zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "(C2H2NOR)nC2H3NOR" xsd:string

[Term]
id: CHEBI:166902
name: noradrenaline(1+)
namespace: chebi_ontology
subset: 2_STAR
synonym: "noradrenaline" RELATED [UniProt]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: is_conjugate_acid_of CHEBI:33569 ! noradrenaline
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H12NO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFLSHLFXELFNJZ-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "170.187" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "170.08117" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(=CC(=C1O)O)C(C[NH3+])O" xsd:string

[Term]
id: CHEBI:167559
name: glycan
namespace: chebi_ontology
def: "Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001." []
subset: 3_STAR
synonym: "glycans" RELATED [ChEBI]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives

[Term]
id: CHEBI:16765
name: tryptamine
namespace: chebi_ontology
alt_id: CHEBI:15274
alt_id: CHEBI:27161
alt_id: CHEBI:46157
alt_id: CHEBI:9767
def: "An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position." []
subset: 3_STAR
synonym: "1H-indole-3-ethanamine" RELATED [NIST_Chemistry_WebBook]
synonym: "2-(1H-INDOL-3-YL)ETHANAMINE" RELATED [PDBeChem]
synonym: "2-(1H-indol-3-yl)ethanamine" EXACT IUPAC_NAME [IUPAC]
synonym: "2-(3-indolyl)ethylamine" RELATED [ChemIDplus]
synonym: "3-(2-Aminoethyl)indole" RELATED [KEGG_COMPOUND]
synonym: "Tryptamine" EXACT [KEGG_COMPOUND]
xref: Beilstein:125513 {source="Beilstein"}
xref: CAS:61-54-1 {source="ChemIDplus"}
xref: CAS:61-54-1 {source="NIST Chemistry WebBook"}
xref: CAS:61-54-1 {source="KEGG COMPOUND"}
xref: DrugBank:DB08653
xref: Gmelin:603448 {source="Gmelin"}
xref: HMDB:HMDB0000303
xref: KEGG:C00398
xref: KNApSAcK:C00001434
xref: MetaCyc:TRYPTAMINE
xref: PDBeChem:TSS
xref: PMID:16126914 {source="Europe PMC"}
xref: PMID:22770225 {source="Europe PMC"}
xref: PMID:24345948 {source="Europe PMC"}
xref: PMID:24558969 {source="Europe PMC"}
xref: Reaxys:125513 {source="Reaxys"}
xref: Wikipedia:Tryptamine
is_a: CHEBI:27162 ! tryptamines
is_a: CHEBI:38631 ! aminoalkylindole
is_a: CHEBI:38958 ! indole alkaloid
is_a: CHEBI:64365 ! aralkylamino compound
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:76924 ! plant metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:57887 ! tryptaminium
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H12N2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "APJYDQYYACXCRM-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "160.21570" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "160.10005" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCCc1c[nH]c2ccccc12" xsd:string

[Term]
id: CHEBI:16990
name: bilirubin IXalpha
namespace: chebi_ontology
alt_id: CHEBI:13898
alt_id: CHEBI:22870
alt_id: CHEBI:3099
def: "A member of the class of  biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin." []
subset: 3_STAR
synonym: "1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid" RELATED [ChemIDplus]
synonym: "2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" RELATED [ChemIDplus]
synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" RELATED [IUPAC]
synonym: "3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione" RELATED [JCBN]
synonym: "Bilirubin" RELATED [KEGG_COMPOUND]
synonym: "bilirubin" EXACT IUPAC_NAME [IUPAC]
synonym: "bilirubin(Z,Z)" RELATED [ChEBI]
synonym: "bilirubin-IXalpha" RELATED [ChEBI]
xref: Beilstein:74376 {source="Beilstein"}
xref: CAS:635-65-4 {source="KEGG COMPOUND"}
xref: CAS:635-65-4 {source="ChemIDplus"}
xref: Gmelin:411033 {source="Gmelin"}
xref: HMDB:HMDB0000054
xref: KEGG:C00486
xref: KNApSAcK:C00029828
xref: MetaCyc:BILIRUBIN
xref: PDBeChem:BLR
xref: PMID:12799017 {source="Europe PMC"}
xref: PMID:18442622 {source="Europe PMC"}
xref: PMID:23763371 {source="Europe PMC"}
xref: PMID:23768684 {source="Europe PMC"}
xref: PMID:30224965 {source="Europe PMC"}
xref: PMID:8605219 {source="Europe PMC"}
xref: PMID:9587403 {source="Europe PMC"}
xref: Reaxys:74376 {source="Reaxys"}
xref: Wikipedia:Bilirubin
is_a: CHEBI:35692 ! dicarboxylic acid
is_a: CHEBI:36735 ! biladienes
relationship: has_part CHEBI:142163 ! 24G7 epitope
relationship: has_role CHEBI:22586 ! antioxidant
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:57977 ! bilirubin(2-)
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H36N4O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BPYKTIZUTYGOLE-IFADSCNNSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "584.673" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "584.26348" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(C=C)\\C(NC1=O)=C\\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\\C=C2/NC(=O)C(C=C)=C2C)N1" xsd:string

[Term]
id: CHEBI:16991
name: deoxyribonucleic acid
namespace: chebi_ontology
alt_id: CHEBI:13302
alt_id: CHEBI:21123
alt_id: CHEBI:33698
alt_id: CHEBI:4291
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." []
subset: 3_STAR
synonym: "(Deoxyribonucleotide)m" RELATED [KEGG_COMPOUND]
synonym: "(Deoxyribonucleotide)n" RELATED [KEGG_COMPOUND]
synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG_COMPOUND]
synonym: "Deoxyribonucleic acid" EXACT [KEGG_COMPOUND]
synonym: "deoxyribonucleic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "deoxyribonucleic acids" RELATED [ChEBI]
synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI]
synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus]
synonym: "DNA" RELATED [UniProt]
synonym: "DNA" RELATED [KEGG_COMPOUND]
synonym: "DNA" RELATED [IUPAC]
synonym: "DNAn" RELATED [KEGG_COMPOUND]
synonym: "DNAn+1" RELATED [KEGG_COMPOUND]
synonym: "DNS" RELATED [ChEBI]
synonym: "thymus nucleic acid" RELATED [ChEBI]
xref: CAS:9007-49-2 {source="ChemIDplus"}
xref: CAS:9007-49-2 {source="KEGG COMPOUND"}
xref: KEGG:C00039
is_a: CHEBI:33696 ! nucleic acid
relationship: has_part CHEBI:33793 ! canonical deoxyribonucleoside residue
relationship: has_part CHEBI:50298 ! canonical deoxyribonucleotide residue
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:17029
name: chitin
namespace: chebi_ontology
alt_id: CHEBI:13962
alt_id: CHEBI:23099
alt_id: CHEBI:3596
def: "An aminoglycan consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." []
subset: 3_STAR
synonym: "(1->4)-2-acetamido-2-deoxy-beta-D-glucan" EXACT IUPAC_NAME [IUPAC]
synonym: "[1,4-(N-Acetyl-beta-D-glucosaminyl)]n" RELATED [KEGG_COMPOUND]
synonym: "[4)-beta-D-GlcpNAc(1->]n" RELATED [IUPAC]
synonym: "beta-1,4-Poly-N-acetyl-D-glucosamine" RELATED [KEGG_COMPOUND]
synonym: "Chitin" EXACT [KEGG_COMPOUND]
synonym: "chitin" EXACT [IUPAC]
synonym: "chitin" EXACT [UniProt]
xref: CAS:1398-61-4 {source="KEGG COMPOUND"}
xref: KEGG:C00461
xref: KEGG:G10483
is_a: CHEBI:21638 ! N-acylglucosamine
is_a: CHEBI:22506 ! aminoglycan
relationship: has_role CHEBI:73336 ! vulnerary
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:77746 ! human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O(C8H13NO5)n" xsd:string

[Term]
id: CHEBI:17087
name: ketone
namespace: chebi_ontology
alt_id: CHEBI:13427
alt_id: CHEBI:13646
alt_id: CHEBI:24974
alt_id: CHEBI:6127
alt_id: CHEBI:8742
def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." []
subset: 3_STAR
synonym: "a ketone" RELATED [UniProt]
synonym: "cetone" RELATED [ChEBI]
synonym: "Keton" RELATED [ChEBI]
synonym: "Ketone" EXACT [KEGG_COMPOUND]
synonym: "ketones" EXACT IUPAC_NAME [IUPAC]
synonym: "ketones" RELATED [ChEBI]
synonym: "R-CO-R'" RELATED [KEGG_COMPOUND]
xref: KEGG:C01450
xref: Wikipedia:Ketone
is_a: CHEBI:36586 ! carbonyl compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "COR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "28.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C([*])=O" xsd:string

[Term]
id: CHEBI:17089
name: glycoprotein
namespace: chebi_ontology
alt_id: CHEBI:14349
alt_id: CHEBI:5481
alt_id: CHEBI:5493
def: "A compound in which a carbohydrate component is covalently bound to a protein component." []
subset: 3_STAR
synonym: "a glycoprotein" RELATED [UniProt]
synonym: "glicoproteina" RELATED [ChEBI]
synonym: "glicoproteinas" RELATED [ChEBI]
synonym: "Glycoprotein" EXACT [KEGG_COMPOUND]
synonym: "glycoproteine" RELATED [ChEBI]
synonym: "glycoproteines" RELATED [ChEBI]
synonym: "glycoproteins" EXACT IUPAC_NAME [IUPAC]
synonym: "Glykoprotein" RELATED [ChEBI]
synonym: "Glykoproteine" RELATED [ChEBI]
xref: KEGG:C00326
is_a: CHEBI:33837 ! conjugated protein
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:17234
name: glucose
namespace: chebi_ontology
alt_id: CHEBI:14313
alt_id: CHEBI:24277
alt_id: CHEBI:33929
alt_id: CHEBI:5418
def: "An aldohexose used as a source of energy and metabolic intermediate." []
subset: 3_STAR
synonym: "DL-glucose" RELATED [ChEBI]
synonym: "Glc" RELATED [JCBN]
synonym: "gluco-hexose" EXACT IUPAC_NAME [IUPAC]
synonym: "Glucose" EXACT [KEGG_COMPOUND]
synonym: "glucose" EXACT IUPAC_NAME [IUPAC]
synonym: "Glukose" RELATED [ChEBI]
xref: CAS:50-99-7 {source="KEGG COMPOUND"}
xref: KEGG:C00293
xref: Wikipedia:Glucose
is_a: CHEBI:33917 ! aldohexose
relationship: has_role CHEBI:78675 ! fundamental metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H12O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "180.15588" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "180.06339" xsd:string

[Term]
id: CHEBI:17544
name: hydrogencarbonate
namespace: chebi_ontology
alt_id: CHEBI:13363
alt_id: CHEBI:22863
alt_id: CHEBI:40961
alt_id: CHEBI:5589
def: "The carbon oxoanion resulting from the removal of a proton from carbonic acid." []
subset: 3_STAR
synonym: "[CO2(OH)](-)" RELATED [IUPAC]
synonym: "Acid carbonate" RELATED [KEGG_COMPOUND]
synonym: "Bicarbonate" RELATED [KEGG_COMPOUND]
synonym: "BICARBONATE ION" RELATED [PDBeChem]
synonym: "HCO3(-)" RELATED [IUPAC]
synonym: "HCO3-" RELATED [KEGG_COMPOUND]
synonym: "hydrogen carbonate" RELATED [PDBeChem]
synonym: "hydrogen(trioxidocarbonate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "Hydrogencarbonate" EXACT [KEGG_COMPOUND]
synonym: "hydrogencarbonate" EXACT [UniProt]
synonym: "hydrogencarbonate" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogencarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentrioxocarbonate(IV)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidodioxidocarbonate(1-)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3903504 {source="Beilstein"}
xref: CAS:71-52-3 {source="ChemIDplus"}
xref: Gmelin:49249 {source="Gmelin"}
xref: HMDB:HMDB0000595
xref: KEGG:C00288
xref: MetaCyc:HCO3
xref: PDBeChem:BCT
xref: PMID:17215880 {source="Europe PMC"}
xref: PMID:17505962 {source="Europe PMC"}
xref: PMID:18439416 {source="Europe PMC"}
xref: PMID:28732801 {source="Europe PMC"}
xref: PMID:29150416 {source="Europe PMC"}
xref: PMID:29460248 {source="Europe PMC"}
xref: PMID:29466234 {source="Europe PMC"}
xref: PMID:4208463 {source="Europe PMC"}
xref: Wikipedia:Bicarbonate
is_a: CHEBI:35604 ! carbon oxoanion
relationship: has_role CHEBI:23357 ! cofactor
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:76971 ! Escherichia coli metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:41609 ! carbonate
relationship: is_conjugate_base_of CHEBI:28976 ! carbonic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "61.01684" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "60.99312" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([O-])=O" xsd:string

[Term]
id: CHEBI:17891
name: donor
namespace: chebi_ontology
alt_id: CHEBI:14202
alt_id: CHEBI:4697
def: "A molecular entity that can transfer (\"donate\") an electron, a pair of electrons, an atom or a group to another molecular entity." []
subset: 3_STAR
synonym: "Donator" RELATED [ChEBI]
synonym: "donneur" RELATED [ChEBI]
synonym: "Donor" EXACT [KEGG_COMPOUND]
xref: KEGG:C01351
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:18059
name: lipid
namespace: chebi_ontology
alt_id: CHEBI:14517
alt_id: CHEBI:25054
alt_id: CHEBI:6486
def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." []
subset: 3_STAR
synonym: "Lipid" EXACT [KEGG_COMPOUND]
synonym: "lipids" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C01356
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:18085
name: glycosaminoglycan
namespace: chebi_ontology
alt_id: CHEBI:14361
alt_id: CHEBI:24398
alt_id: CHEBI:5495
def: "Any polysaccharide containing a substantial proportion of aminomonosaccharide residues." []
subset: 3_STAR
synonym: "glicosaminoglicano" RELATED [IUPAC]
synonym: "Glycosaminoglycan" EXACT [KEGG_COMPOUND]
synonym: "glycosaminoglycan" EXACT IUPAC_NAME [IUPAC]
synonym: "glycosaminoglycane" RELATED [IUPAC]
synonym: "glycosaminoglycans" RELATED [ChEBI]
synonym: "Glykosaminoglykan" RELATED [ChEBI]
xref: KEGG:C02545
xref: Wikipedia:Glycosaminoglycan
is_a: CHEBI:22506 ! aminoglycan

[Term]
id: CHEBI:18133
name: hexose
namespace: chebi_ontology
alt_id: CHEBI:14399
alt_id: CHEBI:24590
alt_id: CHEBI:5709
def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." []
subset: 3_STAR
synonym: "Hexose" EXACT [KEGG_COMPOUND]
synonym: "hexoses" RELATED [ChEBI]
synonym: "WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/" RELATED [GlyTouCan]
xref: GlyGen:G70994MS
xref: GlyTouCan:G70994MS
xref: KEGG:C00738
is_a: CHEBI:35381 ! monosaccharide

[Term]
id: CHEBI:18154
name: polysaccharide
namespace: chebi_ontology
alt_id: CHEBI:14864
alt_id: CHEBI:26205
alt_id: CHEBI:8322
def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." []
subset: 3_STAR
synonym: "Glycan" RELATED [KEGG_COMPOUND]
synonym: "Glycane" RELATED [ChEBI]
synonym: "glycans" RELATED [IUPAC]
synonym: "Glykan" RELATED [ChEBI]
synonym: "Glykane" RELATED [ChEBI]
synonym: "polisacarido" RELATED [ChEBI]
synonym: "polisacaridos" RELATED [IUPAC]
synonym: "Polysaccharide" EXACT [KEGG_COMPOUND]
synonym: "polysaccharides" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00420
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:18282
name: nucleobase
namespace: chebi_ontology
alt_id: CHEBI:13873
alt_id: CHEBI:25598
alt_id: CHEBI:2995
def: "That part of DNA or RNA that may be involved in pairing." []
subset: 3_STAR
synonym: "Base" RELATED [KEGG_COMPOUND]
synonym: "nucleobases" RELATED [ChEBI]
xref: KEGG:C00701
xref: Wikipedia:Nucleobase
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:18357
name: (R)-noradrenaline
namespace: chebi_ontology
alt_id: CHEBI:1
alt_id: CHEBI:14668
alt_id: CHEBI:25592
alt_id: CHEBI:258884
alt_id: CHEBI:43725
def: "The R-enantiomer of noradrenaline." []
subset: 3_STAR
synonym: "(-)-arterenol" RELATED [ChemIDplus]
synonym: "(-)-noradrenaline" RELATED [IUPHAR]
synonym: "(-)-norepinephrine" RELATED [ChemIDplus]
synonym: "(R)-(-)-norepinephrine" RELATED [ChemIDplus]
synonym: "(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol" RELATED [ChemIDplus]
synonym: "(R)-norepinephrine" RELATED [ChemIDplus]
synonym: "4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol" RELATED [KEGG_COMPOUND]
synonym: "4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC]
synonym: "Arterenol" RELATED [KEGG_COMPOUND]
synonym: "L-Noradrenaline" RELATED [KEGG_COMPOUND]
synonym: "L-NOREPINEPHRINE" RELATED [PDBeChem]
synonym: "Noradrenaline" RELATED [KEGG_COMPOUND]
synonym: "norepinefrina" RELATED INN [ChEBI]
synonym: "Norepinephrine" RELATED [KEGG_COMPOUND]
synonym: "norepinephrine" RELATED INN [ChemIDplus]
synonym: "norepinephrine" RELATED INN [WHO_MedNet]
synonym: "norepinephrinum" RELATED INN [ChEBI]
xref: Beilstein:2804840 {source="Beilstein"}
xref: Beilstein:4231961 {source="ChemIDplus"}
xref: CAS:51-41-2 {source="ChemIDplus"}
xref: CAS:51-41-2 {source="KEGG COMPOUND"}
xref: Drug_Central:1960 {source="DrugCentral"}
xref: DrugBank:DB00368
xref: HMDB:HMDB0000216
xref: KEGG:C00547
xref: KEGG:D00076
xref: KNApSAcK:C00001424
xref: PDBeChem:LNR
xref: Reaxys:2804840 {source="Reaxys"}
xref: Wikipedia:Norepinephrine
is_a: CHEBI:33569 ! noradrenaline
relationship: has_role CHEBI:25512 ! neurotransmitter
relationship: has_role CHEBI:35524 ! sympathomimetic agent
relationship: has_role CHEBI:35569 ! alpha-adrenergic agonist
relationship: has_role CHEBI:50514 ! vasoconstrictor agent
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: is_conjugate_base_of CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: is_enantiomer_of CHEBI:33571 ! (S)-noradrenaline
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11NO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFLSHLFXELFNJZ-QMMMGPOBSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "169.17780" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "169.07389" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@H](O)c1ccc(O)c(O)c1" xsd:string

[Term]
id: CHEBI:18367
name: phosphate(3-)
namespace: chebi_ontology
alt_id: CHEBI:14791
alt_id: CHEBI:45024
alt_id: CHEBI:7793
def: "A phosphate ion that is the conjugate base of hydrogenphosphate." []
subset: 3_STAR
synonym: "[PO4](3-)" RELATED [IUPAC]
synonym: "Orthophosphate" RELATED [KEGG_COMPOUND]
synonym: "Phosphate" RELATED [KEGG_COMPOUND]
synonym: "phosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "PHOSPHATE ION" RELATED [PDBeChem]
synonym: "PO4(3-)" RELATED [IUPAC]
synonym: "tetraoxidophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "tetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3903772 {source="Beilstein"}
xref: CAS:14265-44-2 {source="KEGG COMPOUND"}
xref: CAS:14265-44-2 {source="ChemIDplus"}
xref: Gmelin:1997 {source="Gmelin"}
xref: KEGG:C00009
xref: PDBeChem:PO4 {source="ChEBI"}
xref: Reaxys:3903772 {source="Reaxys"}
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79387 ! trivalent inorganic anion
relationship: is_conjugate_base_of CHEBI:43474 ! hydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-K" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "94.97136" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "94.95507" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]P([O-])([O-])=O" xsd:string

[Term]
id: CHEBI:20664
name: 5beta-cholane
namespace: chebi_ontology
subset: 3_STAR
synonym: "5beta-cholane" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:2048472 {source="Beilstein"}
is_a: CHEBI:35519 ! cholane
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H42" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18+,19+,20-,21+,22+,23+,24-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QSHQKIURKJITMZ-OBUPQJQESA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "330.59028" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.32865" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC" xsd:string

[Term]
id: CHEBI:21638
name: N-acylglucosamine
namespace: chebi_ontology
subset: 3_STAR
synonym: "N-acylglucosamine" EXACT [ChEBI]
synonym: "N-acylglucosamines" RELATED [ChEBI]
is_a: CHEBI:21656 ! N-acyl-hexosamine
is_a: CHEBI:24271 ! glucosamines

[Term]
id: CHEBI:21656
name: N-acyl-hexosamine
namespace: chebi_ontology
subset: 3_STAR
synonym: "N-acyl-hexosamine" EXACT [ChEBI]
synonym: "N-acyl-hexosamines" RELATED [ChEBI]
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:22221
name: acyl group
namespace: chebi_ontology
def: "An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids." []
subset: 3_STAR
synonym: "acyl group" EXACT [IUPAC]
synonym: "acyl groups" RELATED [ChEBI]
synonym: "alkanoyl" EXACT IUPAC_NAME [IUPAC]
synonym: "alkanoyl group" RELATED [ChEBI]
synonym: "groupe acyle" RELATED [IUPAC]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:22314
name: alkali metal atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal" RELATED [ChEBI]
synonym: "alkali metals" EXACT IUPAC_NAME [IUPAC]
synonym: "Alkalimetall" RELATED [ChEBI]
synonym: "Alkalimetalle" RELATED [ChEBI]
synonym: "metal alcalin" RELATED [ChEBI]
synonym: "metal alcalino" RELATED [ChEBI]
synonym: "metales alcalinos" RELATED [ChEBI]
synonym: "metaux alcalins" RELATED [ChEBI]
is_a: CHEBI:33318 ! main group element atom
is_a: CHEBI:33521 ! metal atom
is_a: CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:22315
name: alkaloid
namespace: chebi_ontology
def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." []
subset: 3_STAR
synonym: "alcaloide" RELATED [ChEBI]
synonym: "alcaloides" RELATED [ChEBI]
synonym: "Alkaloid" EXACT [ChEBI]
synonym: "Alkaloide" RELATED [ChEBI]
synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC]
xref: Wikipedia:Alkaloid
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_role CHEBI:25212 ! metabolite

[Term]
id: CHEBI:22506
name: aminoglycan
namespace: chebi_ontology
subset: 3_STAR
synonym: "aminoglycans" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:65212 ! polysaccharide derivative

[Term]
id: CHEBI:22563
name: anion
namespace: chebi_ontology
def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." []
subset: 3_STAR
synonym: "Anion" EXACT [ChEBI]
synonym: "anion" EXACT IUPAC_NAME [IUPAC]
synonym: "anion" EXACT [ChEBI]
synonym: "Anionen" RELATED [ChEBI]
synonym: "aniones" RELATED [ChEBI]
synonym: "anions" RELATED [IUPAC]
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:22586
name: antioxidant
namespace: chebi_ontology
def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides." []
subset: 3_STAR
synonym: "antioxidants" RELATED [ChEBI]
synonym: "antioxydant" RELATED [ChEBI]
synonym: "antoxidant" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22695
name: base
namespace: chebi_ontology
def: "A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base)." []
subset: 3_STAR
synonym: "Base" EXACT [ChEBI]
synonym: "base" EXACT [ChEBI]
synonym: "base" EXACT IUPAC_NAME [IUPAC]
synonym: "Base1" RELATED [KEGG_COMPOUND]
synonym: "Base2" RELATED [KEGG_COMPOUND]
synonym: "Basen" RELATED [ChEBI]
synonym: "bases" RELATED [ChEBI]
synonym: "Nucleobase" RELATED [KEGG_COMPOUND]
xref: KEGG:C00701
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:22728
name: benzopyrrole
namespace: chebi_ontology
subset: 3_STAR
synonym: "benzopyrroles" RELATED [ChEBI]
is_a: CHEBI:27171 ! organic heterobicyclic compound
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound
is_a: CHEBI:38180 ! polycyclic heteroarene

[Term]
id: CHEBI:22868
name: bile salt
namespace: chebi_ontology
def: "A sodium salt of the conjugate of any bile acid with either glycine or taurine." []
subset: 3_STAR
synonym: "Bile acid" RELATED [KEGG_COMPOUND]
synonym: "bile salts" RELATED [ChEBI]
xref: KEGG:C01558
is_a: CHEBI:36078 ! cholanoid
is_a: CHEBI:38700 ! organic sodium salt

[Term]
id: CHEBI:23004
name: carbamoyl group
namespace: chebi_ontology
def: "The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid." []
subset: 3_STAR
synonym: "-C(O)NH2" RELATED [ChEBI]
synonym: "-CONH2" RELATED [IUPAC]
synonym: "aminocarbonyl" RELATED [IUPAC]
synonym: "carbamoyl" EXACT IUPAC_NAME [IUPAC]
synonym: "carbamyl" RELATED [ChEBI]
synonym: "carbamyl group" RELATED [ChEBI]
synonym: "carboxamide" RELATED [IUPAC]
xref: PMID:24168430 {source="Europe PMC"}
is_a: CHEBI:27207 ! univalent carboacyl group
relationship: is_substituent_group_from CHEBI:28616 ! carbamic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2NO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.03272" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.01364" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(N)=O" xsd:string

[Term]
id: CHEBI:23019
name: carbonyl group
namespace: chebi_ontology
subset: 3_STAR
synonym: ">C=O" RELATED [IUPAC]
synonym: "carbonyl" EXACT IUPAC_NAME [IUPAC]
synonym: "carbonyl group" EXACT [ChEBI]
synonym: "carbonyl group" EXACT [UniProt]
is_a: CHEBI:51422 ! organodiyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "28.01010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "27.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=C(*)*" xsd:string

[Term]
id: CHEBI:23357
name: cofactor
namespace: chebi_ontology
def: "An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group)." []
subset: 3_STAR
synonym: "cofactor" EXACT [IUPAC]
synonym: "cofactors" EXACT IUPAC_NAME [IUPAC]
xref: Wikipedia:Cofactor_(biochemistry)
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:23367
name: molecular entity
namespace: chebi_ontology
def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [fake:2]
subset: 3_STAR
synonym: "entidad molecular" RELATED [IUPAC]
synonym: "entidades moleculares" RELATED [IUPAC]
synonym: "entite moleculaire" RELATED [IUPAC]
synonym: "molecular entities" RELATED [IUPAC]
synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC]
synonym: "molekulare Entitaet" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:23449
name: cyclic peptide
namespace: chebi_ontology
subset: 3_STAR
synonym: "cyclic peptides" RELATED [ChEBI]
synonym: "Cyclopeptid" RELATED [ChEBI]
synonym: "peptide cyclique" RELATED [IUPAC]
synonym: "peptido ciclico" RELATED [IUPAC]
synonym: "Zyklopeptid" RELATED [ChEBI]
is_a: CHEBI:16670 ! peptide

[Term]
id: CHEBI:23888
name: drug
namespace: chebi_ontology
def: "Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances." []
subset: 3_STAR
synonym: "drugs" RELATED [ChEBI]
synonym: "medicine" RELATED [ChEBI]
is_a: CHEBI:52217 ! pharmaceutical

[Term]
id: CHEBI:23906
name: monoatomic cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic cations" RELATED [ChEBI]
is_a: CHEBI:24867 ! monoatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:23924
name: enzyme inhibitor
namespace: chebi_ontology
def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." []
subset: 3_STAR
synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC]
synonym: "enzyme inhibitors" RELATED [ChEBI]
synonym: "inhibidor enzimatico" RELATED [ChEBI]
synonym: "inhibidores enzimaticos" RELATED [ChEBI]
synonym: "inhibiteur enzymatique" RELATED [ChEBI]
synonym: "inhibiteurs enzymatiques" RELATED [ChEBI]
is_a: CHEBI:35222 ! inhibitor
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:24271
name: glucosamines
namespace: chebi_ontology
def: "Any  hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group." []
subset: 3_STAR
is_a: CHEBI:24586 ! hexosamine

[Term]
id: CHEBI:24384
name: glycogens
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:37163 ! glucan

[Term]
id: CHEBI:24431
name: chemical entity
namespace: chebi_ontology
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." []
subset: 3_STAR
synonym: "chemical entity" EXACT [UniProt]
is_a: BFO:0000030 ! object

[Term]
id: CHEBI:24432
name: biological role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a biological context." []
subset: 3_STAR
synonym: "biological function" RELATED [ChEBI]
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:24433
name: group
namespace: chebi_ontology
def: "A defined linked collection of atoms or a single atom within a molecular entity." []
subset: 3_STAR
synonym: "group" EXACT IUPAC_NAME [IUPAC]
synonym: "groupe" RELATED [IUPAC]
synonym: "grupo" RELATED [IUPAC]
synonym: "grupos" RELATED [IUPAC]
synonym: "Gruppe" RELATED [ChEBI]
synonym: "Rest" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:33250 ! atom

[Term]
id: CHEBI:24532
name: organic heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." []
subset: 3_STAR
synonym: "organic heterocycle" RELATED [ChEBI]
synonym: "organic heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33832 ! organic cyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:24533
name: heterodetic cyclic peptide
namespace: chebi_ontology
def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." []
subset: 3_STAR
synonym: "heterodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC]
synonym: "heterodetic cyclic peptides" RELATED [ChEBI]
synonym: "peptide cyclique heterodetique" RELATED [IUPAC]
synonym: "peptido ciclico heterodetico" RELATED [IUPAC]
is_a: CHEBI:23449 ! cyclic peptide

[Term]
id: CHEBI:24586
name: hexosamine
namespace: chebi_ontology
def: "Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group." []
subset: 3_STAR
synonym: "hexosamine" EXACT [ChEBI]
synonym: "hexosamines" RELATED [ChEBI]
is_a: CHEBI:60926 ! amino monosaccharide

[Term]
id: CHEBI:24621
name: hormone
namespace: chebi_ontology
def: "Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds." []
subset: 3_STAR
synonym: "endocrine" RELATED [ChEBI]
synonym: "hormones" RELATED [ChEBI]
is_a: CHEBI:33280 ! molecular messenger
is_a: CHEBI:48705 ! agonist

[Term]
id: CHEBI:24651
name: hydroxides
namespace: chebi_ontology
def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." []
subset: 3_STAR
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:43176 ! hydroxy group

[Term]
id: CHEBI:24663
name: hydroxy-5beta-cholanic acid
namespace: chebi_ontology
def: "Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position." []
subset: 3_STAR
synonym: "hydroxy-5beta-cholanic acids" RELATED [ChEBI]
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:36248 ! 5beta-cholanic acids
relationship: has_functional_parent CHEBI:36238 ! 5beta-cholanic acid

[Term]
id: CHEBI:24828
name: indoles
namespace: chebi_ontology
def: "Any compound containing an indole skeleton." []
subset: 3_STAR
is_a: CHEBI:22728 ! benzopyrrole

[Term]
id: CHEBI:24833
name: oxoacid
namespace: chebi_ontology
def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." []
subset: 3_STAR
synonym: "oxacids" RELATED [ChEBI]
synonym: "oxiacids" RELATED [ChEBI]
synonym: "oxo acid" RELATED [ChEBI]
synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC]
synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC]
synonym: "oxy-acids" RELATED [ChEBI]
synonym: "oxyacids" RELATED [ChEBI]
is_a: CHEBI:24651 ! hydroxides
relationship: has_role CHEBI:39141 ! Bronsted acid

[Term]
id: CHEBI:24834
name: inorganic anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36914 ! inorganic ion

[Term]
id: CHEBI:24835
name: inorganic molecular entity
namespace: chebi_ontology
def: "A molecular entity that contains no carbon." []
subset: 3_STAR
synonym: "anorganische Verbindungen" RELATED [ChEBI]
synonym: "inorganic compounds" RELATED [ChEBI]
synonym: "inorganic entity" RELATED [ChEBI]
synonym: "inorganic molecular entities" RELATED [ChEBI]
synonym: "inorganics" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:24836
name: inorganic oxide
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic oxides" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25741 ! oxide

[Term]
id: CHEBI:24866
name: salt
namespace: chebi_ontology
def: "A salt is an assembly of cations and anions." []
subset: 3_STAR
synonym: "ionic compound" RELATED [ChEBI]
synonym: "ionic compounds" RELATED [ChEBI]
synonym: "sal" RELATED [ChEBI]
synonym: "sales" RELATED [ChEBI]
synonym: "salt" EXACT IUPAC_NAME [IUPAC]
synonym: "salts" RELATED [ChEBI]
synonym: "Salz" RELATED [ChEBI]
synonym: "Salze" RELATED [ChEBI]
synonym: "sel" RELATED [ChEBI]
synonym: "sels" RELATED [ChEBI]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_part CHEBI:22563 ! anion
relationship: has_part CHEBI:36916 ! cation

[Term]
id: CHEBI:24867
name: monoatomic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:33238 ! monoatomic entity

[Term]
id: CHEBI:24868
name: organic salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic salts" RELATED [ChEBI]
synonym: "organisches Salz" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt

[Term]
id: CHEBI:24870
name: ion
namespace: chebi_ontology
def: "A molecular entity having a net electric charge." []
subset: 3_STAR
synonym: "Ion" EXACT [ChEBI]
synonym: "ion" EXACT IUPAC_NAME [IUPAC]
synonym: "ion" EXACT [ChEBI]
synonym: "Ionen" RELATED [ChEBI]
synonym: "iones" RELATED [ChEBI]
synonym: "ions" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:25046
name: linear tetrapyrrole
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:26932 ! tetrapyrrole

[Term]
id: CHEBI:25212
name: metabolite
namespace: chebi_ontology
alt_id: CHEBI:26619
alt_id: CHEBI:35220
def: "Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites." []
subset: 3_STAR
synonym: "metabolite" EXACT IUPAC_NAME [IUPAC]
synonym: "metabolites" RELATED [ChEBI]
synonym: "primary metabolites" RELATED [ChEBI]
synonym: "secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:52206 ! biochemical role

[Term]
id: CHEBI:25213
name: metal cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "a metal cation" RELATED [UniProt]
synonym: "metal cations" RELATED [ChEBI]
is_a: CHEBI:23906 ! monoatomic cation
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:25362
name: elemental molecule
namespace: chebi_ontology
def: "A molecule all atoms of which have the same atomic number." []
subset: 3_STAR
synonym: "homoatomic molecule" RELATED [ChEBI]
synonym: "homoatomic molecules" RELATED [ChEBI]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:25367
name: molecule
namespace: chebi_ontology
def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." []
subset: 3_STAR
synonym: "molecula" RELATED [IUPAC]
synonym: "molecule" EXACT [IUPAC]
synonym: "molecules" RELATED [IUPAC]
synonym: "Molekuel" RELATED [ChEBI]
synonym: "neutral molecular compounds" RELATED [IUPAC]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:25375
name: monoamine molecular messenger
namespace: chebi_ontology
def: "A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." []
subset: 3_STAR
synonym: "monamines" RELATED [ChEBI]
synonym: "monoamines" RELATED [ChEBI]
is_a: CHEBI:63534 ! monoamine
relationship: has_role CHEBI:33280 ! molecular messenger

[Term]
id: CHEBI:25384
name: monocarboxylic acid
namespace: chebi_ontology
def: "An oxoacid containing a single carboxy group." []
subset: 3_STAR
synonym: "monocarboxylic acids" RELATED [ChEBI]
is_a: CHEBI:33575 ! carboxylic acid
relationship: is_conjugate_acid_of CHEBI:35757 ! monocarboxylic acid anion

[Term]
id: CHEBI:25414
name: monoatomic monocation
namespace: chebi_ontology
subset: 3_STAR
synonym: "monoatomic monocations" RELATED [ChEBI]
synonym: "monovalent inorganic cations" RELATED [ChEBI]
is_a: CHEBI:23906 ! monoatomic cation
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*+]" xsd:string

[Term]
id: CHEBI:25512
name: neurotransmitter
namespace: chebi_ontology
def: "An endogenous compound that is used to transmit information across the synapse between a neuron and another cell." []
subset: 3_STAR
synonym: "neurotransmitters" RELATED [ChEBI]
xref: Wikipedia:Neurotransmitter
is_a: CHEBI:33280 ! molecular messenger

[Term]
id: CHEBI:25555
name: nitrogen atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "7N" RELATED [IUPAC]
synonym: "azote" RELATED [IUPAC]
synonym: "N" RELATED [IUPAC]
synonym: "nitrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "nitrogen" RELATED [ChEBI]
synonym: "nitrogeno" RELATED [ChEBI]
synonym: "Stickstoff" RELATED [ChEBI]
xref: WebElements:N
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "14.007" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string

[Term]
id: CHEBI:25585
name: nonmetal atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "Nichtmetall" RELATED [ChEBI]
synonym: "Nichtmetalle" RELATED [ChEBI]
synonym: "no metal" RELATED [ChEBI]
synonym: "no metales" RELATED [ChEBI]
synonym: "non-metal" RELATED [ChEBI]
synonym: "non-metaux" RELATED [ChEBI]
synonym: "nonmetal" EXACT IUPAC_NAME [IUPAC]
synonym: "nonmetal" RELATED [ChEBI]
synonym: "nonmetals" RELATED [ChEBI]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:25696
name: organic anion
namespace: chebi_ontology
def: "Any organic ion with a net negative charge." []
subset: 3_STAR
synonym: "organic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:25699 ! organic ion

[Term]
id: CHEBI:25697
name: organic cation
namespace: chebi_ontology
def: "Any organic ion with a net positive charge." []
subset: 3_STAR
synonym: "organic cations" RELATED [ChEBI]
is_a: CHEBI:25699 ! organic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:25699
name: organic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:25704
name: organic sulfate
namespace: chebi_ontology
def: "Compounds of the general formula SO3HOR where R is an organyl group" []
subset: 3_STAR
synonym: "organic sulfates" RELATED [ChEBI]
is_a: CHEBI:26820 ! sulfates
relationship: is_conjugate_acid_of CHEBI:58958 ! organosulfate oxoanion

[Term]
id: CHEBI:25741
name: oxide
namespace: chebi_ontology
def: "An oxide is a chemical compound of oxygen with other chemical elements." []
subset: 3_STAR
synonym: "oxide" EXACT [ChEBI]
synonym: "oxides" RELATED [ChEBI]
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:25805
name: oxygen atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "8O" RELATED [IUPAC]
synonym: "O" RELATED [IUPAC]
synonym: "oxigeno" RELATED [ChEBI]
synonym: "oxygen" EXACT IUPAC_NAME [IUPAC]
synonym: "oxygen" RELATED [ChEBI]
synonym: "oxygene" RELATED [ChEBI]
synonym: "Sauerstoff" RELATED [ChEBI]
xref: KEGG:C00007
xref: WebElements:O
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QVGXLLKOCUKJST-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O]" xsd:string

[Term]
id: CHEBI:25806
name: oxygen molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxygen molecular entities" RELATED [ChEBI]
synonym: "oxygen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:25805 ! oxygen atom

[Term]
id: CHEBI:25905
name: peptide hormone
namespace: chebi_ontology
def: "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." []
subset: 3_STAR
synonym: "peptide hormones" RELATED [ChEBI]
synonym: "polypeptide hormone" RELATED [ChEBI]
is_a: CHEBI:16670 ! peptide
relationship: has_role CHEBI:24621 ! hormone

[Term]
id: CHEBI:26020
name: phosphate
namespace: chebi_ontology
def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." []
subset: 3_STAR
synonym: "phosphates" EXACT IUPAC_NAME [IUPAC]
synonym: "phosphates" RELATED [ChEBI]
is_a: CHEBI:26079 ! phosphoric acid derivative

[Term]
id: CHEBI:26078
name: phosphoric acid
namespace: chebi_ontology
def: "A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom." []
subset: 3_STAR
synonym: "[PO(OH)3]" RELATED [IUPAC]
synonym: "acide phosphorique" RELATED [ChEBI]
synonym: "acidum phosphoricum" RELATED [ChEBI]
synonym: "H3PO4" RELATED [IUPAC]
synonym: "Orthophosphoric acid" RELATED [KEGG_COMPOUND]
synonym: "orthophosphoric acid" RELATED [NIST_Chemistry_WebBook]
synonym: "Phosphate" RELATED [KEGG_COMPOUND]
synonym: "Phosphoric acid" EXACT [KEGG_COMPOUND]
synonym: "phosphoric acid" EXACT [IUPAC]
synonym: "Phosphorsaeure" RELATED [ChEBI]
synonym: "Phosphorsaeureloesungen" RELATED [ChEBI]
synonym: "tetraoxophosphoric acid" EXACT IUPAC_NAME [IUPAC]
synonym: "trihydrogen tetraoxophosphate(3-)" EXACT IUPAC_NAME [IUPAC]
synonym: "trihydroxidooxidophosphorus" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:1921286 {source="Beilstein"}
xref: CAS:7664-38-2 {source="NIST Chemistry WebBook"}
xref: CAS:7664-38-2 {source="KEGG COMPOUND"}
xref: CAS:7664-38-2 {source="ChemIDplus"}
xref: Drug_Central:4478 {source="DrugCentral"}
xref: Gmelin:2000 {source="Gmelin"}
xref: HMDB:HMDB0002142
xref: KEGG:C00009
xref: KEGG:D05467
xref: KNApSAcK:C00007408
xref: PMID:11455380 {source="Europe PMC"}
xref: PMID:15630224 {source="Europe PMC"}
xref: PMID:17439666 {source="Europe PMC"}
xref: PMID:17518491 {source="Europe PMC"}
xref: PMID:22282755 {source="Europe PMC"}
xref: PMID:22333268 {source="Europe PMC"}
xref: PMID:22381614 {source="Europe PMC"}
xref: PMID:22401268 {source="Europe PMC"}
xref: Reaxys:1921286 {source="Reaxys"}
xref: Wikipedia:Phosphoric_Acid
is_a: CHEBI:59698 ! phosphoric acids
relationship: has_role CHEBI:33287 ! fertilizer
relationship: has_role CHEBI:46787 ! solvent
relationship: has_role CHEBI:77746 ! human metabolite
relationship: has_role CHEBI:84735 ! algal metabolite
relationship: is_conjugate_acid_of CHEBI:39745 ! dihydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H3O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "97.99520" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.97690" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP(=O)(O[H])O[H]" xsd:string

[Term]
id: CHEBI:26079
name: phosphoric acid derivative
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:36359 ! phosphorus oxoacid derivative
relationship: has_functional_parent CHEBI:26078 ! phosphoric acid

[Term]
id: CHEBI:26082
name: phosphorus molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "phosphorus molecular entities" RELATED [ChEBI]
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:28659 ! phosphorus atom

[Term]
id: CHEBI:26708
name: sodium atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "11Na" RELATED [IUPAC]
synonym: "Na" RELATED [IUPAC]
synonym: "Natrium" RELATED [ChemIDplus]
synonym: "natrium" RELATED [IUPAC]
synonym: "sodio" RELATED [ChemIDplus]
synonym: "sodium" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium" RELATED [ChEBI]
xref: CAS:7440-23-5 {source="ChemIDplus"}
xref: Gmelin:16221 {source="Gmelin"}
xref: KEGG:C01330
xref: WebElements:Na
is_a: CHEBI:22314 ! alkali metal atom
relationship: has_role CHEBI:33937 ! macronutrient
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KEAYESYHFKHZAL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na]" xsd:string

[Term]
id: CHEBI:26712
name: sodium molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "sodium compounds" RELATED [ChEBI]
synonym: "sodium molecular entities" RELATED [ChEBI]
is_a: CHEBI:33296 ! alkali metal molecular entity
relationship: has_part CHEBI:26708 ! sodium atom

[Term]
id: CHEBI:26714
name: sodium salt
namespace: chebi_ontology
def: "Any alkali metal salt having sodium(1+) as the cation." []
subset: 3_STAR
synonym: "Natriumsalz" RELATED [ChEBI]
synonym: "Natriumsalze" RELATED [ChEBI]
synonym: "sodium salts" RELATED [ChEBI]
is_a: CHEBI:26712 ! sodium molecular entity
is_a: CHEBI:35479 ! alkali metal salt
relationship: has_part CHEBI:29101 ! sodium(1+)

[Term]
id: CHEBI:26764
name: steroid hormone
namespace: chebi_ontology
def: "Any steroid that acts as hormone." []
subset: 3_STAR
synonym: "hormona esteroide" RELATED [ChEBI]
synonym: "hormonas esteroideas" RELATED [ChEBI]
synonym: "hormone steroide" RELATED [ChEBI]
synonym: "hormones steroides" RELATED [ChEBI]
synonym: "steroid hormones" RELATED [ChEBI]
synonym: "Steroidhormon" RELATED [ChEBI]
synonym: "Steroidhormone" RELATED [ChEBI]
is_a: CHEBI:35341 ! steroid
relationship: has_role CHEBI:24621 ! hormone

[Term]
id: CHEBI:26819
name: sulfuric ester
namespace: chebi_ontology
def: "An ester of an alcohol and sulfuric acid." []
subset: 3_STAR
synonym: "sulfate ester" RELATED [ChEBI]
synonym: "sulfuric acid ester" RELATED [ChEBI]
synonym: "sulfuric acid esters" RELATED [ChEBI]
is_a: CHEBI:35701 ! ester
is_a: CHEBI:37826 ! sulfuric acid derivative
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]OS(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:26820
name: sulfates
namespace: chebi_ontology
def: "Salts and esters of sulfuric acid" []
subset: 3_STAR
synonym: "sulfates" EXACT [ChEBI]
synonym: "sulfuric acid derivative" RELATED [ChEBI]
synonym: "sulphates" RELATED [ChEBI]
is_a: CHEBI:37826 ! sulfuric acid derivative

[Term]
id: CHEBI:26833
name: sulfur atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "16S" RELATED [IUPAC]
synonym: "azufre" RELATED [ChEBI]
synonym: "Elemental sulfur" RELATED [KEGG_COMPOUND]
synonym: "S" RELATED [KEGG_COMPOUND]
synonym: "S" RELATED [IUPAC]
synonym: "Schwefel" RELATED [ChEBI]
synonym: "soufre" RELATED [ChEBI]
synonym: "sulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfur" RELATED [ChEBI]
synonym: "sulfur" RELATED [UniProt]
synonym: "sulphur" RELATED [ChEBI]
synonym: "theion" RELATED [IUPAC]
xref: CAS:7704-34-9 {source="ChemIDplus"}
xref: CAS:7704-34-9 {source="NIST Chemistry WebBook"}
xref: KEGG:C00087
xref: KEGG:D06527
xref: PPDB:605
xref: WebElements:S
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33303 ! chalcogen
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NINIDFKCEFEMDL-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "32.06600" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.97207" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[S]" xsd:string

[Term]
id: CHEBI:26835
name: sulfur molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfur molecular entities" RELATED [ChEBI]
synonym: "sulfur molecular entity" EXACT [ChEBI]
is_a: CHEBI:33304 ! chalcogen molecular entity
relationship: has_part CHEBI:26833 ! sulfur atom

[Term]
id: CHEBI:26836
name: sulfuric acid
namespace: chebi_ontology
def: "A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom." []
subset: 3_STAR
synonym: "[S(OH)2O2]" RELATED [MolBase]
synonym: "[SO2(OH)2]" RELATED [IUPAC]
synonym: "Acide sulfurique" RELATED [ChemIDplus]
synonym: "Acido sulfurico" RELATED [ChemIDplus]
synonym: "Acidum sulfuricum" RELATED [ChemIDplus]
synonym: "dihydrogen tetraoxosulfate" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidodioxidosulfur" EXACT IUPAC_NAME [IUPAC]
synonym: "H2SO4" RELATED [IUPAC]
synonym: "hydrogen tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogen tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
synonym: "Schwefelsaeureloesungen" RELATED [ChemIDplus]
synonym: "Sulfuric acid" EXACT [KEGG_COMPOUND]
synonym: "sulfuric acid" EXACT IUPAC_NAME [IUPAC]
synonym: "sulfuric acid" EXACT [ChEBI]
synonym: "sulphuric acid" RELATED [MolBase]
synonym: "tetraoxosulfuric acid" EXACT IUPAC_NAME [IUPAC]
xref: CAS:7664-93-9 {source="ChemIDplus"}
xref: CAS:7664-93-9 {source="KEGG COMPOUND"}
xref: CAS:7664-93-9 {source="NIST Chemistry WebBook"}
xref: Gmelin:2122 {source="Gmelin"}
xref: KEGG:C00059
xref: KEGG:D05963
xref: KNApSAcK:C00007530
xref: MolBase:4
xref: PMID:13568755 {source="Europe PMC"}
xref: PMID:16122922 {source="Europe PMC"}
xref: PMID:19397353 {source="Europe PMC"}
xref: PMID:22047659 {source="Europe PMC"}
xref: PMID:22136045 {source="Europe PMC"}
xref: PMID:22204399 {source="Europe PMC"}
xref: PMID:22267186 {source="Europe PMC"}
xref: PMID:22296037 {source="Europe PMC"}
xref: PMID:22364556 {source="Europe PMC"}
xref: PMID:22435616 {source="Europe PMC"}
xref: PPDB:606
xref: Reaxys:2037554 {source="Reaxys"}
xref: Wikipedia:Sulfuric_acid
is_a: CHEBI:33402 ! sulfur oxoacid
relationship: has_role CHEBI:35223 ! catalyst
relationship: is_conjugate_acid_of CHEBI:45696 ! hydrogensulfate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "98.07948" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "97.96738" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS(=O)(=O)O[H]" xsd:string

[Term]
id: CHEBI:26932
name: tetrapyrrole
namespace: chebi_ontology
def: "A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." []
subset: 3_STAR
synonym: "a tetrapyrrole" RELATED [UniProt]
synonym: "tetrapyrrole" EXACT IUPAC_NAME [IUPAC]
synonym: "tetrapyrroles" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:38077 ! polypyrrole

[Term]
id: CHEBI:27027
name: micronutrient
namespace: chebi_ontology
def: "Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions." []
subset: 3_STAR
synonym: "micronutrients" RELATED [ChEBI]
synonym: "trace elements" RELATED [ChEBI]
xref: Wikipedia:Micronutrient
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:27162
name: tryptamines
namespace: chebi_ontology
def: "Tryptamine and its substitution derivatives." []
subset: 3_STAR
is_a: CHEBI:24828 ! indoles

[Term]
id: CHEBI:27171
name: organic heterobicyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "heterobicyclic compounds" RELATED [ChEBI]
synonym: "organic heterobicyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33672 ! heterobicyclic compound
is_a: CHEBI:38166 ! organic heteropolycyclic compound

[Term]
id: CHEBI:27207
name: univalent carboacyl group
namespace: chebi_ontology
def: "A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid." []
subset: 3_STAR
synonym: "univalent acyl group" RELATED [ChEBI]
synonym: "univalent carboacyl groups" RELATED [ChEBI]
synonym: "univalent carboxylic acyl groups" RELATED [ChEBI]
is_a: CHEBI:37838 ! carboacyl group

[Term]
id: CHEBI:27369
name: zwitterion
namespace: chebi_ontology
def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." []
subset: 3_STAR
synonym: "compose zwitterionique" RELATED [IUPAC]
synonym: "compuestos zwitterionicos" RELATED [IUPAC]
synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC]
synonym: "zwitteriones" RELATED [IUPAC]
synonym: "zwitterionic compounds" RELATED [IUPAC]
synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:51151 ! dipolar compound

[Term]
id: CHEBI:27594
name: carbon atom
namespace: chebi_ontology
alt_id: CHEBI:23009
alt_id: CHEBI:3399
subset: 3_STAR
synonym: "6C" RELATED [IUPAC]
synonym: "C" RELATED [KEGG_COMPOUND]
synonym: "C" RELATED [IUPAC]
synonym: "Carbon" RELATED [KEGG_COMPOUND]
synonym: "carbon" EXACT IUPAC_NAME [IUPAC]
synonym: "carbon" RELATED [ChEBI]
synonym: "carbone" RELATED [ChEBI]
synonym: "carbonium" RELATED [ChEBI]
synonym: "carbono" RELATED [ChEBI]
synonym: "Kohlenstoff" RELATED [ChEBI]
xref: CAS:7440-44-0 {source="ChemIDplus"}
xref: CAS:7440-44-0 {source="KEGG COMPOUND"}
xref: KEGG:C06265
xref: WebElements:C
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33306 ! carbon group element atom
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OKTJSMMVPCPJKN-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "12.01070" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "12.00000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[C]" xsd:string

[Term]
id: CHEBI:28087
name: glycogen
namespace: chebi_ontology
alt_id: CHEBI:24379
alt_id: CHEBI:5466
def: "A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues." []
subset: 3_STAR
synonym: "animal starch" RELATED [ChemIDplus]
synonym: "Glycogen" EXACT [KEGG_COMPOUND]
synonym: "liver starch" RELATED [ChemIDplus]
synonym: "WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1" RELATED [GlyTouCan]
xref: CAS:9005-79-2 {source="KEGG COMPOUND"}
xref: CAS:9005-79-2 {source="ChemIDplus"}
xref: GlyGen:G99991IU
xref: GlyTouCan:G99991IU
xref: HMDB:HMDB0000757
xref: KEGG:C00182
xref: MetaCyc:CPD0-971
xref: Wikipedia:Glycogen
is_a: CHEBI:24384 ! glycogens
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:76971 ! Escherichia coli metabolite

[Term]
id: CHEBI:28616
name: carbamic acid
namespace: chebi_ontology
alt_id: CHEBI:22504
alt_id: CHEBI:23002
alt_id: CHEBI:3386
alt_id: CHEBI:44573
def: "A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised." []
subset: 3_STAR
synonym: "Aminoameisensaeure" RELATED [ChEBI]
synonym: "Aminoformic acid" RELATED [KEGG_COMPOUND]
synonym: "Carbamate" RELATED [KEGG_COMPOUND]
synonym: "CARBAMIC ACID" EXACT [PDBeChem]
synonym: "Carbamic acid" EXACT [KEGG_COMPOUND]
synonym: "carbamic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Carbamidsaeure" RELATED [ChEBI]
xref: Beilstein:1734754 {source="Beilstein"}
xref: CAS:463-77-4 {source="KEGG COMPOUND"}
xref: CAS:463-77-4 {source="ChemIDplus"}
xref: DrugBank:DB04261
xref: Gmelin:130345 {source="Gmelin"}
xref: KEGG:C01563
xref: PDBeChem:OUT
xref: Wikipedia:Carbamic_acid
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:64708 ! one-carbon compound
relationship: has_role CHEBI:76971 ! Escherichia coli metabolite
relationship: is_conjugate_acid_of CHEBI:13941 ! carbamate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH3NO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH3NO2/c2-1(3)4/h2H2,(H,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "KXDHJXZQYSOELW-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "61.04006" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "61.01638" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC(O)=O" xsd:string

[Term]
id: CHEBI:28659
name: phosphorus atom
namespace: chebi_ontology
alt_id: CHEBI:26080
alt_id: CHEBI:8168
subset: 3_STAR
synonym: "15P" RELATED [IUPAC]
synonym: "fosforo" RELATED [ChEBI]
synonym: "P" RELATED [IUPAC]
synonym: "P" RELATED [KEGG_COMPOUND]
synonym: "Phosphor" RELATED [ChEBI]
synonym: "phosphore" RELATED [ChEBI]
synonym: "Phosphorus" RELATED [KEGG_COMPOUND]
synonym: "phosphorus" EXACT IUPAC_NAME [IUPAC]
synonym: "phosphorus" RELATED [ChEBI]
xref: CAS:7723-14-0 {source="ChemIDplus"}
xref: CAS:7723-14-0 {source="KEGG COMPOUND"}
xref: Gmelin:16235 {source="Gmelin"}
xref: KEGG:C06262
xref: WebElements:P
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33300 ! pnictogen
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "OAICVXFJPJFONN-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "30.97376" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "30.97376" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[P]" xsd:string

[Term]
id: CHEBI:28790
name: serotonin
namespace: chebi_ontology
alt_id: CHEBI:1420
alt_id: CHEBI:26652
alt_id: CHEBI:49894
def: "A primary amino compound that is the 5-hydroxy derivative of tryptamine." []
subset: 3_STAR
synonym: "3-(2-Aminoethyl)-1H-indol-5-ol" RELATED [KEGG_COMPOUND]
synonym: "3-(2-aminoethyl)-1H-indol-5-ol" EXACT IUPAC_NAME [IUPAC]
synonym: "5-HT" RELATED [IUPHAR]
synonym: "5-Hydroxytryptamine" RELATED [KEGG_COMPOUND]
synonym: "Enteramine" RELATED [KEGG_COMPOUND]
synonym: "SEROTONIN" EXACT [PDBeChem]
synonym: "Serotonin" EXACT [KEGG_COMPOUND]
synonym: "serotonine" RELATED [ChEBI]
synonym: "thrombocytin" RELATED [ChemIDplus]
synonym: "thrombotonin" RELATED [ChemIDplus]
xref: Beilstein:143524 {source="Beilstein"}
xref: CAS:50-67-9 {source="KEGG COMPOUND"}
xref: CAS:50-67-9 {source="ChemIDplus"}
xref: Gmelin:1861995 {source="Gmelin"}
xref: HMDB:HMDB0000259
xref: KEGG:C00780
xref: KNApSAcK:C00001429
xref: LINCS:LSM-6589
xref: MetaCyc:SEROTONIN
xref: PDBeChem:SRO
xref: PMID:18593914 {source="Europe PMC"}
xref: PMID:22770225 {source="Europe PMC"}
xref: PMID:24136337 {source="Europe PMC"}
xref: Reaxys:143524 {source="Reaxys"}
xref: Wikipedia:Serotonin
is_a: CHEBI:25375 ! monoamine molecular messenger
is_a: CHEBI:27162 ! tryptamines
is_a: CHEBI:33853 ! phenols
is_a: CHEBI:50994 ! primary amino compound
is_a: CHEBI:84729 ! hydroxyindoles
relationship: has_functional_parent CHEBI:16765 ! tryptamine
relationship: has_role CHEBI:25512 ! neurotransmitter
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:350546 ! serotonin(1+)
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H12N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QZAYGJVTTNCVMB-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "176.215" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "176.09496" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1=CC(=CC=2C(=CNC12)CCN)O" xsd:string

[Term]
id: CHEBI:28938
name: ammonium
namespace: chebi_ontology
alt_id: CHEBI:22534
alt_id: CHEBI:49783
alt_id: CHEBI:7435
def: "An onium cation obtained by protonation of ammonia." []
subset: 3_STAR
synonym: "[NH4](+)" RELATED [MolBase]
synonym: "ammonium" EXACT IUPAC_NAME [IUPAC]
synonym: "ammonium" EXACT [ChEBI]
synonym: "ammonium cation" RELATED [ChemIDplus]
synonym: "ammonium ion" RELATED [PDBeChem]
synonym: "Ammonium(1+)" RELATED [ChemIDplus]
synonym: "azanium" EXACT IUPAC_NAME [IUPAC]
synonym: "NH4(+)" RELATED [UniProt]
synonym: "NH4(+)" RELATED [IUPAC]
synonym: "NH4+" RELATED [KEGG_COMPOUND]
xref: CAS:14798-03-9 {source="NIST Chemistry WebBook"}
xref: CAS:14798-03-9 {source="ChemIDplus"}
xref: Gmelin:84 {source="Gmelin"}
xref: KEGG:C01342
xref: MetaCyc:AMMONIUM
xref: MolBase:929
xref: PDBeChem:NH4
xref: PMID:11319011 {source="Europe PMC"}
xref: PMID:11341317 {source="Europe PMC"}
xref: PMID:12096804 {source="Europe PMC"}
xref: PMID:14512268 {source="Europe PMC"}
xref: PMID:14879753 {source="Europe PMC"}
xref: PMID:16345391 {source="Europe PMC"}
xref: PMID:16903292 {source="Europe PMC"}
xref: PMID:17392693 {source="Europe PMC"}
xref: PMID:18515490 {source="Europe PMC"}
xref: PMID:19199063 {source="Europe PMC"}
xref: PMID:19596600 {source="Europe PMC"}
xref: PMID:19682559 {source="Europe PMC"}
xref: PMID:19716251 {source="Europe PMC"}
xref: PMID:21993530 {source="Europe PMC"}
xref: PMID:22265469 {source="Europe PMC"}
xref: PMID:22524020 {source="Europe PMC"}
xref: PMID:22562341 {source="Europe PMC"}
xref: PMID:22631217 {source="Europe PMC"}
xref: Reaxys:16093784 {source="Reaxys"}
xref: Wikipedia:Ammonium
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:50313 ! onium cation
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: has_role CHEBI:23357 ! cofactor
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:76971 ! Escherichia coli metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:16134 ! ammonia
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H4N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3N/h1H3/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QGZKDVFQNNGYKY-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "18.03850" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "18.03383" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N+]([H])([H])[H]" xsd:string

[Term]
id: CHEBI:28963
name: amino sugar
namespace: chebi_ontology
alt_id: CHEBI:22481
alt_id: CHEBI:22530
alt_id: CHEBI:2662
def: "Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups." []
subset: 3_STAR
synonym: "amino sugars" RELATED [ChEBI]
synonym: "aminosugar" RELATED [ChEBI]
synonym: "Aminosugars" RELATED [KEGG_COMPOUND]
xref: KEGG:C05383
xref: PMID:18424273 {source="Europe PMC"}
xref: PMID:9056391 {source="Europe PMC"}
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:28965
name: dicarboxylic acid dianion
namespace: chebi_ontology
alt_id: CHEBI:13632
alt_id: CHEBI:23688
alt_id: CHEBI:23689
alt_id: CHEBI:38711
def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." []
subset: 3_STAR
synonym: "a dicarboxylate" RELATED [UniProt]
synonym: "dicarboxylate" RELATED [ChEBI]
synonym: "dicarboxylates" RELATED [ChEBI]
synonym: "dicarboxylic acid dianion" EXACT [ChEBI]
synonym: "dicarboxylic acid dianions" RELATED [ChEBI]
is_a: CHEBI:35693 ! dicarboxylic acid anion
is_a: CHEBI:38716 ! carboxylic acid dianion
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2O4R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "88.019" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "87.97966" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C(=O)[*]C([O-])=O" xsd:string

[Term]
id: CHEBI:28976
name: carbonic acid
namespace: chebi_ontology
alt_id: CHEBI:13351
alt_id: CHEBI:23017
alt_id: CHEBI:23744
alt_id: CHEBI:3401
subset: 3_STAR
synonym: "[CO(OH)2]" RELATED [IUPAC]
synonym: "Carbonic acid" EXACT [KEGG_COMPOUND]
synonym: "carbonic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Dihydrogen carbonate" RELATED [KEGG_COMPOUND]
synonym: "dihydroxidooxidocarbon" EXACT IUPAC_NAME [IUPAC]
synonym: "H2CO3" RELATED [KEGG_COMPOUND]
synonym: "H2CO3" RELATED [IUPAC]
synonym: "Koehlensaeure" RELATED [ChEBI]
xref: CAS:463-79-6 {source="ChemIDplus"}
xref: CAS:463-79-6 {source="KEGG COMPOUND"}
xref: Gmelin:25554 {source="Gmelin"}
xref: KEGG:C01353
xref: PDBeChem:CO3
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36961 ! chalcocarbonic acid
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: is_conjugate_acid_of CHEBI:17544 ! hydrogencarbonate
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CH2O3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "62.02478" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "62.00039" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC(O)=O" xsd:string

[Term]
id: CHEBI:29067
name: carboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13626
alt_id: CHEBI:13945
alt_id: CHEBI:23026
alt_id: CHEBI:58657
def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." []
subset: 3_STAR
synonym: "a carboxylate" RELATED [UniProt]
synonym: "carboxylic acid anions" RELATED [ChEBI]
synonym: "carboxylic anions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
relationship: is_conjugate_base_of CHEBI:33575 ! carboxylic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.00950" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:29101
name: sodium(1+)
namespace: chebi_ontology
alt_id: CHEBI:26717
alt_id: CHEBI:49766
alt_id: CHEBI:9175
def: "A monoatomic monocation obtained from sodium." []
subset: 3_STAR
synonym: "Na(+)" RELATED [UniProt]
synonym: "Na(+)" RELATED [IUPAC]
synonym: "Na+" RELATED [KEGG_COMPOUND]
synonym: "sodium cation" EXACT IUPAC_NAME [IUPAC]
synonym: "SODIUM ION" RELATED [PDBeChem]
synonym: "sodium(1+)" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium(1+) ion" EXACT IUPAC_NAME [IUPAC]
synonym: "sodium(I) cation" EXACT IUPAC_NAME [IUPAC]
xref: CAS:17341-25-2 {source="ChemIDplus"}
xref: CAS:17341-25-2 {source="NIST Chemistry WebBook"}
xref: Gmelin:15196 {source="Gmelin"}
xref: KEGG:C01330
xref: PDBeChem:NA
is_a: CHEBI:25414 ! monoatomic monocation
is_a: CHEBI:33504 ! alkali metal cation
is_a: CHEBI:37246 ! elemental sodium
is_a: CHEBI:60242 ! monovalent inorganic cation
relationship: has_role CHEBI:23357 ! cofactor
relationship: has_role CHEBI:77746 ! human metabolite
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "Na" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/Na/q+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "FKNQFGJONOIPTF-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "22.98977" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "22.98922" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[Na+]" xsd:string

[Term]
id: CHEBI:29337
name: azanide
namespace: chebi_ontology
subset: 3_STAR
synonym: "amide" EXACT IUPAC_NAME [IUPAC]
synonym: "azanide" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydridonitrate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "NH2(-)" RELATED [IUPAC]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:29340 ! hydridonitrate(2-)
relationship: is_conjugate_base_of CHEBI:16134 ! ammonia
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2N/h1H2/q-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "HYGWNUKOUCZBND-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "16.02262" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "16.01927" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][N-][H]" xsd:string

[Term]
id: CHEBI:29340
name: hydridonitrate(2-)
namespace: chebi_ontology
def: "A divalent inorganic anion resulting from the removal of two protons from ammonia." []
subset: 3_STAR
synonym: "azanediide" EXACT IUPAC_NAME [IUPAC]
synonym: "hydridonitrate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "imide" RELATED [IUPAC]
synonym: "NH(2-)" RELATED [IUPAC]
is_a: CHEBI:35106 ! nitrogen hydride
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: is_conjugate_base_of CHEBI:29337 ! azanide
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HN" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/HN/h1H/q-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "DZQYTNGKSBCIOE-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.01468" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.01200" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[N--][H]" xsd:string

[Term]
id: CHEBI:29793
name: hydridodioxygen(1+)
namespace: chebi_ontology
subset: 3_STAR
synonym: "[HO2](+)" RELATED [ChEBI]
synonym: "dioxidenium" EXACT IUPAC_NAME [IUPAC]
synonym: "HO2(+)" RELATED [IUPAC]
synonym: "HOO(+)" RELATED [ChEBI]
synonym: "hydridodioxygen(1+)" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:508 {source="Gmelin"}
is_a: CHEBI:33693 ! oxygen hydride
relationship: is_conjugate_acid_of CHEBI:15379 ! dioxygen
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/O2/c1-2/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MYMOFIZGZYHOMD-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "33.00674" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "32.99711" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][O+]=O" xsd:string

[Term]
id: CHEBI:30089
name: acetate
namespace: chebi_ontology
alt_id: CHEBI:13704
alt_id: CHEBI:22165
alt_id: CHEBI:40480
def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." []
subset: 3_STAR
synonym: "acetate" EXACT [UniProt]
synonym: "acetate" EXACT IUPAC_NAME [IUPAC]
synonym: "ACETATE ION" RELATED [PDBeChem]
synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus]
synonym: "Azetat" RELATED [ChEBI]
synonym: "CH3-COO(-)" RELATED [IUPAC]
synonym: "Ethanoat" RELATED [ChEBI]
synonym: "ethanoate" RELATED [ChEBI]
synonym: "MeCO2 anion" RELATED [NIST_Chemistry_WebBook]
xref: Beilstein:1901470 {source="Beilstein"}
xref: CAS:71-50-1 {source="ChemIDplus"}
xref: CAS:71-50-1 {source="NIST Chemistry WebBook"}
xref: DrugBank:DB03166
xref: Gmelin:1379 {source="Gmelin"}
xref: KEGG:C00033
xref: MetaCyc:ACET
xref: PDBeChem:ACT
xref: PMID:17190852 {source="Europe PMC"}
xref: PMID:22211106 {source="Europe PMC"}
xref: PMID:22371380 {source="Europe PMC"}
xref: Reaxys:1901470 {source="Reaxys"}
xref: UM-BBD_compID:c0050 {source="UM-BBD"}
xref: Wikipedia:Acetate
is_a: CHEBI:35757 ! monocarboxylic acid anion
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:15366 ! acetic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QTBSBXVTEAMEQO-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "59.04402" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01385" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC([O-])=O" xsd:string

[Term]
id: CHEBI:30212
name: photon
namespace: chebi_ontology
alt_id: CHEBI:10581
alt_id: CHEBI:14383
def: "Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force." []
subset: 3_STAR
synonym: "foton" RELATED [ChEBI]
synonym: "gamma" RELATED [IUPAC]
synonym: "hnu" RELATED [IUPAC]
synonym: "hnu" RELATED [UniProt]
synonym: "Lichtquant" RELATED [ChEBI]
synonym: "Light" RELATED [KEGG_COMPOUND]
synonym: "light quantum" RELATED [ChEBI]
synonym: "photon" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00205
is_a: CHEBI:36341 ! boson
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "0.0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "0.0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*" xsd:string

[Term]
id: CHEBI:3098
name: bile acid
namespace: chebi_ontology
def: "Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration." []
subset: 3_STAR
synonym: "5beta-bile acid" RELATED [ChEBI]
synonym: "5beta-bile acids" RELATED [ChEBI]
synonym: "Bile acid" EXACT [KEGG_COMPOUND]
synonym: "bile acids" RELATED [ChEBI]
synonym: "Bile salt" RELATED [KEGG_COMPOUND]
synonym: "Gallensaeure" RELATED [ChEBI]
synonym: "Gallensaeuren" RELATED [ChEBI]
xref: KEGG:C01558
is_a: CHEBI:138366 ! bile acids
is_a: CHEBI:24663 ! hydroxy-5beta-cholanic acid

[Term]
id: CHEBI:32952
name: amine
namespace: chebi_ontology
alt_id: CHEBI:13814
alt_id: CHEBI:22474
alt_id: CHEBI:2641
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." []
subset: 3_STAR
synonym: "Amin" RELATED [ChEBI]
synonym: "Amine" EXACT [KEGG_COMPOUND]
synonym: "amines" EXACT IUPAC_NAME [IUPAC]
synonym: "Substituted amine" RELATED [KEGG_COMPOUND]
xref: KEGG:C00706
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:32988
name: amide
namespace: chebi_ontology
alt_id: CHEBI:22473
alt_id: CHEBI:2633
def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3_STAR
synonym: "Amide" EXACT [KEGG_COMPOUND]
synonym: "amides" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00241
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:33232
name: application
namespace: chebi_ontology
def: "Intended use of the molecular entity or part thereof by humans." []
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:33233
name: fundamental particle
namespace: chebi_ontology
def: "A particle not known to have substructure." []
subset: 3_STAR
synonym: "elementary particle" EXACT IUPAC_NAME [IUPAC]
synonym: "elementary particles" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:33238
name: monoatomic entity
namespace: chebi_ontology
def: "A monoatomic entity is a molecular entity consisting of a single atom." []
subset: 3_STAR
synonym: "atomic entity" RELATED [ChEBI]
synonym: "monoatomic entities" RELATED [ChEBI]
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33241
name: oxoacid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoacid derivatives" RELATED [ChEBI]
is_a: CHEBI:37577 ! heteroatomic molecular entity
relationship: has_functional_parent CHEBI:24833 ! oxoacid

[Term]
id: CHEBI:33242
name: inorganic hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic hydrides" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:33245
name: organic fundamental parent
namespace: chebi_ontology
def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." []
subset: 3_STAR
synonym: "organic fundamental parents" RELATED [ChEBI]
synonym: "organic parent hydrides" RELATED [ChEBI]
is_a: CHEBI:37175 ! organic hydride
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33246
name: inorganic group
namespace: chebi_ontology
def: "Any substituent group which does not contain carbon." []
subset: 3_STAR
synonym: "inorganic groups" RELATED [ChEBI]
is_a: CHEBI:24433 ! group

[Term]
id: CHEBI:33247
name: organic group
namespace: chebi_ontology
def: "Any substituent group or skeleton containing carbon." []
subset: 3_STAR
synonym: "organic groups" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
is_a: CHEBI:24433 ! group
relationship: is_substituent_group_from CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33249
name: organyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having one free valence at a carbon atom." []
subset: 3_STAR
synonym: "groupe organyle" RELATED [IUPAC]
synonym: "grupo organilo" RELATED [IUPAC]
synonym: "grupos organilo" RELATED [IUPAC]
synonym: "organyl group" EXACT IUPAC_NAME [IUPAC]
synonym: "organyl groups" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:51447 ! organic univalent group

[Term]
id: CHEBI:33250
name: atom
namespace: chebi_ontology
alt_id: CHEBI:22671
alt_id: CHEBI:23907
def: "A chemical entity constituting the smallest component of an element having the chemical properties of the element." []
subset: 3_STAR
synonym: "atom" EXACT IUPAC_NAME [IUPAC]
synonym: "atome" RELATED [IUPAC]
synonym: "atomo" RELATED [IUPAC]
synonym: "atoms" RELATED [ChEBI]
synonym: "atomus" RELATED [ChEBI]
synonym: "element" RELATED [ChEBI]
synonym: "elements" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity
relationship: has_part CHEBI:10545 ! electron
relationship: has_part CHEBI:33252 ! atomic nucleus

[Term]
id: CHEBI:33252
name: atomic nucleus
namespace: chebi_ontology
def: "A nucleus is the positively charged central portion of an atom, excluding the orbital electrons." []
subset: 3_STAR
synonym: "Atomkern" RELATED [ChEBI]
synonym: "Kern" RELATED [ChEBI]
synonym: "noyau" RELATED [IUPAC]
synonym: "noyau atomique" RELATED [ChEBI]
synonym: "nuclei" RELATED [ChEBI]
synonym: "nucleo" RELATED [IUPAC]
synonym: "nucleo atomico" RELATED [ChEBI]
synonym: "nucleus" EXACT IUPAC_NAME [IUPAC]
synonym: "nucleus atomi" RELATED [ChEBI]
is_a: CHEBI:36347 ! nuclear particle
relationship: has_part CHEBI:33253 ! nucleon

[Term]
id: CHEBI:33253
name: nucleon
namespace: chebi_ontology
def: "Heavy nuclear particle: proton or neutron." []
subset: 3_STAR
synonym: "nucleon" EXACT [IUPAC]
synonym: "nucleon" EXACT IUPAC_NAME [IUPAC]
synonym: "nucleons" RELATED [ChEBI]
synonym: "Nukleon" RELATED [ChEBI]
synonym: "Nukleonen" RELATED [ChEBI]
is_a: CHEBI:36339 ! baryon
is_a: CHEBI:36347 ! nuclear particle

[Term]
id: CHEBI:33256
name: primary amide
namespace: chebi_ontology
def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." []
subset: 3_STAR
synonym: "primary amide" EXACT [IUPAC]
synonym: "primary amides" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:32988 ! amide

[Term]
id: CHEBI:33259
name: elemental molecular entity
namespace: chebi_ontology
def: "A molecular entity all atoms of which have the same atomic number." []
subset: 3_STAR
synonym: "homoatomic entity" RELATED [ChEBI]
synonym: "homoatomic molecular entities" RELATED [ChEBI]
synonym: "homoatomic molecular entity" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity

[Term]
id: CHEBI:33262
name: elemental oxygen
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:33259 ! elemental molecular entity

[Term]
id: CHEBI:33263
name: diatomic oxygen
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:33262 ! elemental oxygen
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "31.999" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "31.98983" xsd:string

[Term]
id: CHEBI:33273
name: polyatomic anion
namespace: chebi_ontology
def: "An anion consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic anions" RELATED [ChEBI]
is_a: CHEBI:22563 ! anion
is_a: CHEBI:36358 ! polyatomic ion

[Term]
id: CHEBI:33280
name: molecular messenger
namespace: chebi_ontology
subset: 3_STAR
synonym: "chemical messenger" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33281
name: antimicrobial agent
namespace: chebi_ontology
alt_id: CHEBI:22582
def: "A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans." []
subset: 3_STAR
synonym: "antibiotic" RELATED [ChEBI]
synonym: "antibiotics" RELATED [ChEBI]
synonym: "Antibiotika" RELATED [ChEBI]
synonym: "Antibiotikum" RELATED [ChEBI]
synonym: "antibiotique" RELATED [IUPAC]
synonym: "antimicrobial" RELATED [ChEBI]
synonym: "antimicrobial agents" RELATED [ChEBI]
synonym: "antimicrobials" RELATED [ChEBI]
synonym: "microbicide" RELATED [ChEBI]
synonym: "microbicides" RELATED [ChEBI]
xref: PMID:12964249 {source="Europe PMC"}
xref: PMID:22117953 {source="Europe PMC"}
xref: PMID:22439833 {source="Europe PMC"}
xref: PMID:22849268 {source="Europe PMC"}
xref: PMID:22849276 {source="Europe PMC"}
xref: PMID:22958833 {source="Europe PMC"}
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:33284
name: nutrient
namespace: chebi_ontology
def: "A nutrient is a food component that an organism uses to survive and grow." []
subset: 3_STAR
synonym: "nutrients" RELATED [ChEBI]
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:33285
name: heteroorganic entity
namespace: chebi_ontology
def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." []
subset: 3_STAR
synonym: "heteroorganic entities" RELATED [ChEBI]
synonym: "organoelement compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33286
name: agrochemical
namespace: chebi_ontology
def: "An agrochemical is a substance that is used in agriculture or horticulture." []
subset: 3_STAR
synonym: "agrichemical" RELATED [ChEBI]
synonym: "agrichemicals" RELATED [ChEBI]
synonym: "agricultural chemicals" RELATED [ChEBI]
synonym: "agrochemicals" RELATED [ChEBI]
xref: Wikipedia:Agrochemical
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33287
name: fertilizer
namespace: chebi_ontology
def: "A fertilizer is any substance that is added to soil or water to assist the growth of plants." []
subset: 3_STAR
synonym: "fertiliser" RELATED [ChEBI]
synonym: "fertilizers" RELATED [ChEBI]
is_a: CHEBI:33286 ! agrochemical

[Term]
id: CHEBI:33296
name: alkali metal molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms of an alkali metal." []
subset: 3_STAR
synonym: "alkali metal molecular entities" RELATED [ChEBI]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:22314 ! alkali metal atom

[Term]
id: CHEBI:33300
name: pnictogen
namespace: chebi_ontology
def: "Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth." []
subset: 3_STAR
synonym: "group 15 elements" RELATED [ChEBI]
synonym: "group V elements" RELATED [ChEBI]
synonym: "nitrogenoideos" RELATED [ChEBI]
synonym: "nitrogenoides" RELATED [ChEBI]
synonym: "pnictogene" RELATED [ChEBI]
synonym: "pnictogenes" RELATED [ChEBI]
synonym: "pnictogens" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33302
name: pnictogen molecular entity
namespace: chebi_ontology
def: "A p-block molecular entity containing any pnictogen." []
subset: 3_STAR
synonym: "pnictogen molecular entities" RELATED [ChEBI]
synonym: "pnictogen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33300 ! pnictogen

[Term]
id: CHEBI:33303
name: chalcogen
namespace: chebi_ontology
def: "Any p-block element belonging to the group 16 family of the periodic table." []
subset: 3_STAR
synonym: "anfigeno" RELATED [ChEBI]
synonym: "anfigenos" RELATED [ChEBI]
synonym: "calcogeno" RELATED [ChEBI]
synonym: "calcogenos" RELATED [ChEBI]
synonym: "chalcogen" EXACT IUPAC_NAME [IUPAC]
synonym: "chalcogene" RELATED [ChEBI]
synonym: "chalcogenes" RELATED [ChEBI]
synonym: "chalcogens" EXACT IUPAC_NAME [IUPAC]
synonym: "Chalkogen" RELATED [ChEBI]
synonym: "Chalkogene" RELATED [ChEBI]
synonym: "group 16 elements" RELATED [ChEBI]
synonym: "group VI elements" RELATED [ChEBI]
xref: PMID:17084588 {source="Europe PMC"}
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33304
name: chalcogen molecular entity
namespace: chebi_ontology
def: "Any p-block molecular entity containing a chalcogen." []
subset: 3_STAR
synonym: "chalcogen compounds" RELATED [ChEBI]
synonym: "chalcogen molecular entities" RELATED [ChEBI]
synonym: "chalcogen molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33303 ! chalcogen

[Term]
id: CHEBI:33306
name: carbon group element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon group element" RELATED [ChEBI]
synonym: "carbon group elements" RELATED [ChEBI]
synonym: "carbonoides" RELATED [ChEBI]
synonym: "cristallogene" RELATED [ChEBI]
synonym: "cristallogenes" RELATED [ChEBI]
synonym: "group 14 elements" EXACT IUPAC_NAME [IUPAC]
synonym: "group IV elements" RELATED [ChEBI]
is_a: CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33308
name: carboxylic ester
namespace: chebi_ontology
alt_id: CHEBI:13204
alt_id: CHEBI:23028
alt_id: CHEBI:3408
def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." []
subset: 3_STAR
synonym: "a carboxylic ester" RELATED [UniProt]
synonym: "carboxylic acid esters" RELATED [ChEBI]
synonym: "Carboxylic ester" EXACT [KEGG_COMPOUND]
synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C02391
xref: Wikipedia:Ester
is_a: CHEBI:35701 ! ester
is_a: CHEBI:36586 ! carbonyl compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)O[*]" xsd:string

[Term]
id: CHEBI:33318
name: main group element atom
namespace: chebi_ontology
def: "An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table." []
subset: 3_STAR
synonym: "Hauptgruppenelement" RELATED [ChEBI]
synonym: "Hauptgruppenelemente" RELATED [ChEBI]
synonym: "main group element" RELATED [ChEBI]
synonym: "main group elements" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33402
name: sulfur oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoacids of sulfur" RELATED [ChEBI]
synonym: "sulfur oxoacids" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33484 ! chalcogen oxoacid

[Term]
id: CHEBI:33408
name: pnictogen oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen oxoacids" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_role CHEBI:138103 ! inorganic acid

[Term]
id: CHEBI:33424
name: sulfur oxoacid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfur oxoacid derivative" EXACT [ChEBI]
synonym: "sulfur oxoacid derivatives" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33241 ! oxoacid derivative

[Term]
id: CHEBI:33457
name: phosphorus oxoacid
namespace: chebi_ontology
def: "A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons." []
subset: 3_STAR
synonym: "oxoacids of phosphorus" RELATED [ChEBI]
synonym: "Oxosaeure des Phosphors" RELATED [ChEBI]
synonym: "phosphorus oxoacid" EXACT [ChEBI]
synonym: "phosphorus oxoacids" RELATED [ChEBI]
is_a: CHEBI:33408 ! pnictogen oxoacid
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives

[Term]
id: CHEBI:33459
name: pnictogen oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen oxoanion" EXACT [ChEBI]
synonym: "pnictogen oxoanions" RELATED [ChEBI]
is_a: CHEBI:33302 ! pnictogen molecular entity
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33461
name: phosphorus oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoanions of phosphorus" RELATED [ChEBI]
synonym: "phosphorus oxoanion" EXACT [ChEBI]
synonym: "phosphorus oxoanions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion
is_a: CHEBI:26082 ! phosphorus molecular entity
is_a: CHEBI:33459 ! pnictogen oxoanion

[Term]
id: CHEBI:33482
name: sulfur oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxoanions of sulfur" RELATED [ChEBI]
synonym: "sulfur oxoanion" EXACT [ChEBI]
synonym: "sulfur oxoanions" RELATED [ChEBI]
is_a: CHEBI:26835 ! sulfur molecular entity
is_a: CHEBI:33485 ! chalcogen oxoanion

[Term]
id: CHEBI:33484
name: chalcogen oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcogen oxoacid" EXACT [ChEBI]
synonym: "chalcogen oxoacids" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
relationship: has_role CHEBI:138103 ! inorganic acid

[Term]
id: CHEBI:33485
name: chalcogen oxoanion
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcogen oxoanion" EXACT [ChEBI]
synonym: "chalcogen oxoanions" RELATED [ChEBI]
is_a: CHEBI:35406 ! oxoanion

[Term]
id: CHEBI:33504
name: alkali metal cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal cations" RELATED [ChEBI]
is_a: CHEBI:25213 ! metal cation

[Term]
id: CHEBI:33521
name: metal atom
namespace: chebi_ontology
alt_id: CHEBI:25217
alt_id: CHEBI:6788
def: "An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity." []
subset: 3_STAR
synonym: "elemental metal" RELATED [ChEBI]
synonym: "elemental metals" RELATED [ChEBI]
synonym: "metal element" RELATED [ChEBI]
synonym: "metal elements" RELATED [ChEBI]
synonym: "metals" RELATED [ChEBI]
xref: KEGG:C00050
xref: PMID:21784043 {source="Europe PMC"}
xref: Wikipedia:Metal
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33558
name: alpha-amino-acid anion
namespace: chebi_ontology
def: "An amino-acid anion obtained by deprotonation of any alpha-amino acid." []
subset: 3_STAR
synonym: "alpha-amino acid anions" RELATED [ChEBI]
synonym: "alpha-amino-acid anion" EXACT [ChEBI]
synonym: "alpha-amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:37022 ! amino-acid anion
relationship: is_conjugate_base_of CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33559
name: s-block element atom
namespace: chebi_ontology
subset: 3_STAR
synonym: "s-block element" RELATED [ChEBI]
synonym: "s-block elements" RELATED [ChEBI]
is_a: CHEBI:33250 ! atom

[Term]
id: CHEBI:33560
name: p-block element atom
namespace: chebi_ontology
def: "Any main group element atom belonging to the p-block of the periodic table." []
subset: 3_STAR
synonym: "p-block element" RELATED [ChEBI]
synonym: "p-block elements" RELATED [ChEBI]
is_a: CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33566
name: catechols
namespace: chebi_ontology
alt_id: CHEBI:134187
alt_id: CHEBI:13628
alt_id: CHEBI:18862
def: "Any compound containing an o-diphenol component." []
subset: 3_STAR
synonym: "1,2-benzenediols" RELATED [ChEBI]
synonym: "a catechol" RELATED [UniProt]
synonym: "benzene-1,2-diols" RELATED [ChEBI]
xref: KEGG:C15571
is_a: CHEBI:33570 ! benzenediols
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H2O2R4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "106.079" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "106.00548" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC1=C(O)C(*)=C(*)C(*)=C1*" xsd:string

[Term]
id: CHEBI:33567
name: catecholamine
namespace: chebi_ontology
alt_id: CHEBI:23056
alt_id: CHEBI:3468
def: "4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." []
subset: 3_STAR
synonym: "Catecholamine" EXACT [KEGG_COMPOUND]
synonym: "catecholamines" EXACT IUPAC_NAME [IUPAC]
synonym: "catecholamines" RELATED [ChEBI]
xref: KEGG:C02012
is_a: CHEBI:25375 ! monoamine molecular messenger
is_a: CHEBI:33566 ! catechols
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H9NO2R2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "151.163" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "151.06333" xsd:string

[Term]
id: CHEBI:33569
name: noradrenaline
namespace: chebi_ontology
def: "A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted." []
subset: 3_STAR
synonym: "4-(2-amino-1-hydroxyethyl)benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC]
synonym: "noradrenalina" RELATED [ChEBI]
synonym: "norepinephrine" RELATED [ChEBI]
xref: Beilstein:2210994 {source="Beilstein"}
xref: CAS:138-65-8 {source="NIST Chemistry WebBook"}
xref: CAS:138-65-8 {source="ChemIDplus"}
xref: Gmelin:863925 {source="Gmelin"}
xref: LINCS:LSM-5181
is_a: CHEBI:33567 ! catecholamine
relationship: has_role CHEBI:76967 ! human xenobiotic metabolite
relationship: is_conjugate_base_of CHEBI:166902 ! noradrenaline(1+)
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11NO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFLSHLFXELFNJZ-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "169.17788" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "169.07389" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NCC(O)c1ccc(O)c(O)c1" xsd:string

[Term]
id: CHEBI:33570
name: benzenediols
namespace: chebi_ontology
alt_id: CHEBI:22705
alt_id: CHEBI:22711
subset: 3_STAR
is_a: CHEBI:33853 ! phenols

[Term]
id: CHEBI:33571
name: (S)-noradrenaline
namespace: chebi_ontology
def: "The S-enantiomer of noradrenaline." []
subset: 3_STAR
synonym: "4-[(1S)-2-amino-1-hydroxyethyl]benzene-1,2-diol" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:2937999 {source="Beilstein"}
xref: LINCS:LSM-37072
xref: Reaxys:2937999 {source="Reaxys"}
is_a: CHEBI:33569 ! noradrenaline
relationship: is_enantiomer_of CHEBI:18357 ! (R)-noradrenaline
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H11NO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFLSHLFXELFNJZ-MRVPVSSYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "169.17788" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "169.07389" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC[C@@H](O)c1ccc(O)c(O)c1" xsd:string

[Term]
id: CHEBI:33575
name: carboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:13428
alt_id: CHEBI:13627
alt_id: CHEBI:23027
def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." []
subset: 3_STAR
synonym: "acide carboxylique" RELATED [IUPAC]
synonym: "acides carboxyliques" RELATED [IUPAC]
synonym: "acido carboxilico" RELATED [IUPAC]
synonym: "acidos carboxilicos" RELATED [IUPAC]
synonym: "Carbonsaeure" RELATED [ChEBI]
synonym: "Carbonsaeuren" RELATED [ChEBI]
synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "Karbonsaeure" RELATED [ChEBI]
synonym: "RC(=O)OH" RELATED [IUPAC]
xref: PMID:17147560 {source="Europe PMC"}
xref: PMID:18433345 {source="Europe PMC"}
xref: Wikipedia:Carboxylic_acid
is_a: CHEBI:35605 ! carbon oxoacid
is_a: CHEBI:36586 ! carbonyl compound
is_a: CHEBI:64709 ! organic acid
relationship: has_part CHEBI:46883 ! carboxy group
relationship: is_conjugate_acid_of CHEBI:29067 ! carboxylic acid anion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01740" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OC([*])=O" xsd:string

[Term]
id: CHEBI:33579
name: main group molecular entity
namespace: chebi_ontology
def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." []
subset: 3_STAR
synonym: "main group compounds" RELATED [ChEBI]
synonym: "main group molecular entities" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:33318 ! main group element atom

[Term]
id: CHEBI:33582
name: carbon group molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon group molecular entities" RELATED [ChEBI]
synonym: "carbon group molecular entity" EXACT [ChEBI]
is_a: CHEBI:33675 ! p-block molecular entity
relationship: has_part CHEBI:33306 ! carbon group element atom

[Term]
id: CHEBI:33595
name: cyclic compound
namespace: chebi_ontology
def: "Any molecule that consists of a series of atoms joined together to form a ring." []
subset: 3_STAR
synonym: "cyclic compounds" RELATED [ChEBI]
xref: Wikipedia:Cyclic_compound
is_a: CHEBI:25367 ! molecule

[Term]
id: CHEBI:33608
name: hydrogen molecular entity
namespace: chebi_ontology
subset: 3_STAR
synonym: "hydrogen compounds" RELATED [ChEBI]
synonym: "hydrogen molecular entities" RELATED [ChEBI]
is_a: CHEBI:33674 ! s-block molecular entity
relationship: has_part CHEBI:49637 ! hydrogen atom

[Term]
id: CHEBI:33635
name: polycyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "polycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33636
name: bicyclic compound
namespace: chebi_ontology
def: "A molecule that features two fused rings." []
subset: 3_STAR
synonym: "bicyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33655
name: aromatic compound
namespace: chebi_ontology
def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." []
subset: 3_STAR
synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC]
synonym: "aromatics" RELATED [ChEBI]
synonym: "aromatische Verbindungen" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:33659
name: organic aromatic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic aromatic compounds" RELATED [ChEBI]
is_a: CHEBI:33655 ! aromatic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:33671
name: heteropolycyclic compound
namespace: chebi_ontology
def: "A polycyclic compound in which at least one of the rings contains at least one non-carbon atom." []
subset: 3_STAR
synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "polyheterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33672
name: heterobicyclic compound
namespace: chebi_ontology
def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." []
subset: 3_STAR
synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33636 ! bicyclic compound
is_a: CHEBI:5686 ! heterocyclic compound

[Term]
id: CHEBI:33674
name: s-block molecular entity
namespace: chebi_ontology
def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." []
subset: 3_STAR
synonym: "s-block compounds" RELATED [ChEBI]
synonym: "s-block molecular entities" RELATED [ChEBI]
synonym: "s-block molecular entity" EXACT [ChEBI]
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33559 ! s-block element atom

[Term]
id: CHEBI:33675
name: p-block molecular entity
namespace: chebi_ontology
def: "A main group molecular entity that contains one or more atoms of a p-block element." []
subset: 3_STAR
synonym: "p-block compounds" RELATED [ChEBI]
synonym: "p-block molecular entities" RELATED [ChEBI]
synonym: "p-block molecular entitiy" RELATED [ChEBI]
is_a: CHEBI:33579 ! main group molecular entity
relationship: has_part CHEBI:33560 ! p-block element atom

[Term]
id: CHEBI:33692
name: hydrides
namespace: chebi_ontology
def: "Hydrides are chemical compounds of hydrogen with other chemical elements." []
subset: 3_STAR
is_a: CHEBI:33608 ! hydrogen molecular entity
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:33693
name: oxygen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "hydrides of oxygen" RELATED [ChEBI]
synonym: "oxygen hydride" EXACT [ChEBI]
synonym: "oxygen hydrides" RELATED [ChEBI]
is_a: CHEBI:36902 ! chalcogen hydride

[Term]
id: CHEBI:33694
name: biomacromolecule
namespace: chebi_ontology
def: "A macromolecule formed by a living organism." []
subset: 3_STAR
synonym: "biomacromolecules" RELATED [ChEBI]
synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC]
synonym: "Biopolymere" RELATED [ChEBI]
synonym: "biopolymers" RELATED [ChEBI]
is_a: CHEBI:33839 ! macromolecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33695
name: information biomacromolecule
namespace: chebi_ontology
subset: 3_STAR
synonym: "genetically encoded biomacromolecules" RELATED [ChEBI]
synonym: "genetically encoded biopolymers" RELATED [ChEBI]
synonym: "information biomacromolecules" RELATED [ChEBI]
synonym: "information biopolymers" RELATED [ChEBI]
synonym: "information macromolecule" RELATED [ChEBI]
synonym: "information macromolecules" RELATED [ChEBI]
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:33696
name: nucleic acid
namespace: chebi_ontology
def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." []
subset: 3_STAR
synonym: "acide nucleique" RELATED [ChEBI]
synonym: "acides nucleiques" RELATED [ChEBI]
synonym: "acido nucleico" RELATED [ChEBI]
synonym: "acidos nucleicos" RELATED [ChEBI]
synonym: "NA" RELATED [ChEBI]
synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "Nukleinsaeure" RELATED [ChEBI]
synonym: "Nukleinsaeuren" RELATED [ChEBI]
is_a: CHEBI:15986 ! polynucleotide
relationship: has_part CHEBI:33791 ! canonical nucleoside residue
relationship: has_part CHEBI:50297 ! canonical nucleotide residue

[Term]
id: CHEBI:33697
name: ribonucleic acid
namespace: chebi_ontology
def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." []
subset: 3_STAR
synonym: "pentosenucleic acids" RELATED [ChemIDplus]
synonym: "ribonucleic acid" EXACT [IUPAC]
synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "ribonucleic acids" RELATED [ChEBI]
synonym: "Ribonukleinsaeure" RELATED [ChEBI]
synonym: "ribose nucleic acid" RELATED [ChEBI]
synonym: "RNA" RELATED [UniProt]
synonym: "RNA" RELATED [IUPAC]
synonym: "RNS" RELATED [ChEBI]
synonym: "yeast nucleic acid" RELATED [ChEBI]
xref: CAS:63231-63-0 {source="ChemIDplus"}
is_a: CHEBI:33696 ! nucleic acid
relationship: has_part CHEBI:33792 ! canonical ribonucleoside residue
relationship: has_part CHEBI:50299 ! canonical ribonucleotide residue

[Term]
id: CHEBI:33700
name: proteinogenic amino-acid residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical amino-acid residue" RELATED [ChEBI]
synonym: "canonical amino-acid residues" RELATED [ChEBI]
synonym: "common amino acid residues" RELATED [ChEBI]
synonym: "proteinogenic amino-acid residues" RELATED [ChEBI]
synonym: "standard amino acid residues" RELATED [ChEBI]
synonym: "standard amino-acid residues" RELATED [ChEBI]
is_a: CHEBI:33710 ! alpha-amino-acid residue

[Term]
id: CHEBI:33702
name: polyatomic cation
namespace: chebi_ontology
def: "A cation consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic cations" RELATED [ChEBI]
is_a: CHEBI:36358 ! polyatomic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:33704
name: alpha-amino acid
namespace: chebi_ontology
alt_id: CHEBI:10208
alt_id: CHEBI:13779
alt_id: CHEBI:22442
alt_id: CHEBI:2642
def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." []
subset: 3_STAR
synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC]
synonym: "alpha-amino acids" RELATED [JCBN]
synonym: "alpha-amino acids" RELATED [ChEBI]
synonym: "alpha-amino carboxylic acids" RELATED [IUPAC]
synonym: "Amino acid" RELATED [KEGG_COMPOUND]
synonym: "Amino acids" RELATED [KEGG_COMPOUND]
xref: KEGG:C00045
xref: KEGG:C05167
is_a: CHEBI:33709 ! amino acid
relationship: is_conjugate_acid_of CHEBI:33558 ! alpha-amino-acid anion
relationship: is_tautomer_of CHEBI:78608 ! alpha-amino acid zwitterion
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.05870" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "NC([*])C(O)=O" xsd:string

[Term]
id: CHEBI:33708
name: amino-acid residue
namespace: chebi_ontology
def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [Dummy:dummy]
subset: 3_STAR
synonym: "amino acid residue" EXACT []
synonym: "amino acid residue" RELATED [ChEBI]
synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC]
synonym: "amino-acid residues" RELATED [JCBN]
synonym: "protein residue" NARROW [PRO:DAN]
is_a: CHEBI:33247 ! organic group
relationship: is_substituent_group_from CHEBI:33709 ! amino acid

[Term]
id: CHEBI:33709
name: amino acid
namespace: chebi_ontology
alt_id: CHEBI:13815
alt_id: CHEBI:22477
def: "A carboxylic acid containing one or more amino groups." []
subset: 3_STAR
synonym: "amino acids" RELATED [ChEBI]
synonym: "Aminocarbonsaeure" RELATED [ChEBI]
synonym: "Aminokarbonsaeure" RELATED [ChEBI]
synonym: "Aminosaeure" RELATED [ChEBI]
xref: Wikipedia:Amino_acid
is_a: CHEBI:33575 ! carboxylic acid
is_a: CHEBI:50047 ! organic amino compound
relationship: is_conjugate_acid_of CHEBI:37022 ! amino-acid anion

[Term]
id: CHEBI:33710
name: alpha-amino-acid residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "alpha-amino-acid residues" RELATED [ChEBI]
is_a: CHEBI:33708 ! amino-acid residue
relationship: is_substituent_group_from CHEBI:33704 ! alpha-amino acid

[Term]
id: CHEBI:33720
name: carbohydrate acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbohydrate acid" EXACT [ChEBI]
synonym: "carbohydrate acids" RELATED [ChEBI]
is_a: CHEBI:16646 ! carbohydrate
is_a: CHEBI:33575 ! carboxylic acid
relationship: is_conjugate_acid_of CHEBI:33721 ! carbohydrate acid anion

[Term]
id: CHEBI:33721
name: carbohydrate acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbohydrate acid anion" EXACT [ChEBI]
synonym: "carbohydrate acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:33720 ! carbohydrate acid

[Term]
id: CHEBI:33791
name: canonical nucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical nucleoside residues" RELATED [ChEBI]
synonym: "common nucleoside residues" RELATED [CBN]
synonym: "nucleoside residue" RELATED [CBN]
synonym: "standard nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:50320 ! nucleoside residue

[Term]
id: CHEBI:33792
name: canonical ribonucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical ribonucleoside residues" RELATED [ChEBI]
synonym: "common ribonucleoside residue" RELATED [CBN]
synonym: "common ribonucleoside residues" RELATED [CBN]
synonym: "N" RELATED [CBN]
synonym: "Nuc" RELATED [CBN]
synonym: "standard ribonucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33791 ! canonical nucleoside residue

[Term]
id: CHEBI:33793
name: canonical deoxyribonucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical deoxyribonucleoside residues" RELATED [ChEBI]
synonym: "common 2'-deoxyribonucleoside residue" RELATED [CBN]
synonym: "common 2'-deoxyribonucleoside residues" RELATED [CBN]
synonym: "dN" RELATED [CBN]
synonym: "dNuc" RELATED [CBN]
synonym: "standard deoxyribonucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33791 ! canonical nucleoside residue

[Term]
id: CHEBI:33822
name: organic hydroxy compound
namespace: chebi_ontology
alt_id: CHEBI:64710
def: "An organic compound having at least one hydroxy group attached to a carbon atom." []
subset: 3_STAR
synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "organic alcohol" RELATED [ChEBI]
synonym: "organic hydroxy compounds" RELATED [ChEBI]
is_a: CHEBI:24651 ! hydroxides
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:33832
name: organic cyclic compound
namespace: chebi_ontology
def: "Any organic molecule that consists of atoms connected in the form of a ring." []
subset: 3_STAR
synonym: "organic cyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:33833
name: heteroarene
namespace: chebi_ontology
def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." []
subset: 3_STAR
synonym: "hetarenes" RELATED [IUPAC]
synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33659 ! organic aromatic compound

[Term]
id: CHEBI:33837
name: conjugated protein
namespace: chebi_ontology
def: "Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion." []
subset: 3_STAR
synonym: "complex protein" RELATED [COMe]
synonym: "conjugated proteins" EXACT IUPAC_NAME [IUPAC]
xref: COMe:PRX000001
is_a: CHEBI:36080 ! protein

[Term]
id: CHEBI:33839
name: macromolecule
namespace: chebi_ontology
def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." []
subset: 3_STAR
synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC]
synonym: "macromolecules" RELATED [ChEBI]
synonym: "polymer" RELATED [ChEBI]
synonym: "polymer molecule" RELATED [IUPAC]
synonym: "polymers" RELATED [ChEBI]
xref: Wikipedia:Macromolecule
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:33853
name: phenols
namespace: chebi_ontology
alt_id: CHEBI:13664
alt_id: CHEBI:13825
alt_id: CHEBI:25969
alt_id: CHEBI:2857
def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." []
subset: 3_STAR
synonym: "a phenol" RELATED [UniProt]
synonym: "arenols" RELATED [IUPAC]
synonym: "Aryl alcohol" RELATED [KEGG_COMPOUND]
synonym: "phenols" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C15584
xref: MetaCyc:Phenols
xref: Wikipedia:Phenols
is_a: CHEBI:33659 ! organic aromatic compound
is_a: CHEBI:33822 ! organic hydroxy compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6HOR5" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "89.072" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "89.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C(C(=C1*)*)*)*)*)O" xsd:string

[Term]
id: CHEBI:33893
name: reagent
namespace: chebi_ontology
def: "A substance used in a chemical reaction to detect, measure, examine, or produce other substances." []
subset: 3_STAR
synonym: "reactif" RELATED [IUPAC]
synonym: "reactivo" RELATED [IUPAC]
synonym: "reagent" EXACT IUPAC_NAME [IUPAC]
synonym: "reagents" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:33917
name: aldohexose
namespace: chebi_ontology
alt_id: CHEBI:2558
def: "A hexose with a (potential) aldehyde group at one end." []
subset: 3_STAR
synonym: "aldohexose" EXACT [ChEBI]
synonym: "aldohexoses" RELATED [ChEBI]
is_a: CHEBI:15693 ! aldose
is_a: CHEBI:18133 ! hexose

[Term]
id: CHEBI:33937
name: macronutrient
namespace: chebi_ontology
def: "Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals." []
subset: 3_STAR
synonym: "macronutrients" RELATED [ChEBI]
is_a: CHEBI:33284 ! nutrient

[Term]
id: CHEBI:350546
name: serotonin(1+)
namespace: chebi_ontology
def: "An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3." []
subset: 3_STAR
synonym: "2-(5-hydroxy-1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC]
synonym: "serotonin" RELATED [UniProt]
synonym: "serotonin cation" RELATED [ChEBI]
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:28790 ! serotonin
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H13N2O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QZAYGJVTTNCVMB-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "177.22250" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "177.10224" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CCc1c[nH]c2ccc(O)cc12" xsd:string

[Term]
id: CHEBI:35106
name: nitrogen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "nitrogen hydrides" RELATED [ChEBI]
is_a: CHEBI:35881 ! pnictogen hydride
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35107
name: azane
namespace: chebi_ontology
def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." []
subset: 3_STAR
synonym: "azanes" RELATED [ChEBI]
is_a: CHEBI:35106 ! nitrogen hydride

[Term]
id: CHEBI:35222
name: inhibitor
namespace: chebi_ontology
def: "A substance that diminishes the rate of a chemical reaction." []
subset: 3_STAR
synonym: "inhibidor" RELATED [ChEBI]
synonym: "inhibiteur" RELATED [ChEBI]
synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC]
synonym: "inhibitors" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:35223
name: catalyst
namespace: chebi_ontology
def: "A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction." []
subset: 3_STAR
synonym: "catalizador" RELATED [ChEBI]
synonym: "catalyseur" RELATED [ChEBI]
synonym: "catalyst" EXACT IUPAC_NAME [IUPAC]
synonym: "Katalysator" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:35238
name: amino acid zwitterion
namespace: chebi_ontology
def: "The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group." []
subset: 3_STAR
synonym: "amino acid zwitterion" EXACT [ChEBI]
is_a: CHEBI:27369 ! zwitterion

[Term]
id: CHEBI:35267
name: quaternary ammonium ion
namespace: chebi_ontology
alt_id: CHEBI:26470
alt_id: CHEBI:8693
def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups." []
subset: 3_STAR
synonym: "a quaternary ammonium" RELATED [UniProt]
synonym: "Quaternary amine" RELATED [KEGG_COMPOUND]
synonym: "quaternary ammonium ion" EXACT IUPAC_NAME [IUPAC]
synonym: "quaternary ammonium ions" RELATED [ChEBI]
xref: KEGG:C06703
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "NR4" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "14.00670" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "14.00307" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*][N+]([*])([*])[*]" xsd:string

[Term]
id: CHEBI:35274
name: ammonium ion derivative
namespace: chebi_ontology
def: "A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc)." []
subset: 3_STAR
synonym: "ammonium ion derivatives" RELATED [ChEBI]
synonym: "azanium ion derivative" RELATED [ChEBI]
synonym: "azanium ion derivatives" RELATED [ChEBI]
is_a: CHEBI:33702 ! polyatomic cation
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: has_parent_hydride CHEBI:28938 ! ammonium

[Term]
id: CHEBI:35287
name: acylcholine
namespace: chebi_ontology
alt_id: CHEBI:13245
alt_id: CHEBI:22227
alt_id: CHEBI:2463
def: "A choline ester formed from choline and a carboxylic acid." []
subset: 3_STAR
synonym: "acylcholines" RELATED [ChEBI]
synonym: "an acylcholine" RELATED [UniProt]
xref: KEGG:C01777
is_a: CHEBI:35267 ! quaternary ammonium ion
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C6H13NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "131.17290" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "131.09463" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[N+](C)(C)CCOC([*])=O" xsd:string

[Term]
id: CHEBI:35341
name: steroid
namespace: chebi_ontology
alt_id: CHEBI:13687
alt_id: CHEBI:26768
alt_id: CHEBI:9263
def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene." []
subset: 3_STAR
synonym: "a steroid" RELATED [UniProt]
synonym: "Steroid" EXACT [KEGG_COMPOUND]
synonym: "steroids" EXACT IUPAC_NAME [IUPAC]
xref: KEGG:C00377
xref: MetaCyc:Steroids
is_a: CHEBI:18059 ! lipid
is_a: CHEBI:51958 ! organic polycyclic compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C19H31R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "259.450" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "259.24258" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C12C(C3C(C(CC3)*)(C)CC1)CCC4C2(CCCC4)C" xsd:string

[Term]
id: CHEBI:35350
name: hydroxy steroid
namespace: chebi_ontology
alt_id: CHEBI:24748
alt_id: CHEBI:5814
subset: 3_STAR
synonym: "hydroxy steroids" RELATED [ChEBI]
synonym: "Hydroxysteroid" RELATED [KEGG_COMPOUND]
synonym: "hydroxysteroids" RELATED [ChEBI]
xref: KEGG:C02159
is_a: CHEBI:33822 ! organic hydroxy compound
is_a: CHEBI:35341 ! steroid

[Term]
id: CHEBI:35352
name: organonitrogen compound
namespace: chebi_ontology
def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." []
subset: 3_STAR
synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC]
synonym: "organonitrogens" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:51143 ! nitrogen molecular entity

[Term]
id: CHEBI:35381
name: monosaccharide
namespace: chebi_ontology
alt_id: CHEBI:25407
alt_id: CHEBI:6984
def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." []
subset: 3_STAR
synonym: "monosacarido" RELATED [ChEBI]
synonym: "monosacaridos" RELATED [IUPAC]
synonym: "Monosaccharid" RELATED [ChEBI]
synonym: "Monosaccharide" EXACT [KEGG_COMPOUND]
synonym: "monosaccharides" EXACT IUPAC_NAME [IUPAC]
synonym: "Monosacharid" RELATED [ChEBI]
xref: KEGG:C06698
is_a: CHEBI:16646 ! carbohydrate

[Term]
id: CHEBI:35406
name: oxoanion
namespace: chebi_ontology
alt_id: CHEBI:33274
alt_id: CHEBI:33436
def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." []
subset: 3_STAR
synonym: "oxoacid anions" RELATED [ChEBI]
synonym: "oxoanion" EXACT [ChEBI]
synonym: "oxoanions" RELATED [ChEBI]
is_a: CHEBI:25741 ! oxide
is_a: CHEBI:33273 ! polyatomic anion

[Term]
id: CHEBI:35472
name: anti-inflammatory drug
namespace: chebi_ontology
def: "A substance that reduces or suppresses inflammation." []
subset: 3_STAR
synonym: "anti-inflammatory drugs" RELATED [ChEBI]
synonym: "antiinflammatory agent" RELATED [ChEBI]
synonym: "antiinflammatory drug" RELATED [ChEBI]
synonym: "antiinflammatory drugs" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:67079 ! anti-inflammatory agent

[Term]
id: CHEBI:35479
name: alkali metal salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "alkali metal salts" RELATED [ChEBI]
is_a: CHEBI:24866 ! salt
is_a: CHEBI:33296 ! alkali metal molecular entity

[Term]
id: CHEBI:35507
name: natural product fundamental parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "natural product fundamental parents" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33245 ! organic fundamental parent

[Term]
id: CHEBI:35508
name: steroid fundamental parent
namespace: chebi_ontology
subset: 3_STAR
synonym: "steroid fundamental parents" RELATED [ChEBI]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:35507 ! natural product fundamental parent

[Term]
id: CHEBI:35519
name: cholane
namespace: chebi_ontology
subset: 3_STAR
synonym: "cholane" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:35508 ! steroid fundamental parent
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H42" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H42/c1-5-8-17(2)20-12-13-21-19-11-10-18-9-6-7-15-23(18,3)22(19)14-16-24(20,21)4/h17-22H,5-16H2,1-4H3/t17-,18?,19+,20-,21+,22+,23+,24-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QSHQKIURKJITMZ-BRPMRXRMSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "330.59028" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "330.32865" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC" xsd:string

[Term]
id: CHEBI:35524
name: sympathomimetic agent
namespace: chebi_ontology
def: "A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." []
subset: 3_STAR
synonym: "sympathomimetic" RELATED [ChEBI]
synonym: "sympathomimetics" RELATED [ChEBI]
is_a: CHEBI:37962 ! adrenergic agent

[Term]
id: CHEBI:35554
name: cardiovascular drug
namespace: chebi_ontology
def: "A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume." []
subset: 3_STAR
synonym: "cardiovascular agent" RELATED [ChEBI]
synonym: "cardiovascular drugs" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:35569
name: alpha-adrenergic agonist
namespace: chebi_ontology
def: "An agent that selectively binds to and activates alpha-adrenergic receptors." []
subset: 3_STAR
synonym: "alpha-adrenergic agonists" RELATED [ChEBI]
synonym: "alpha-adrenergic receptor agonist" RELATED [ChEBI]
synonym: "alpha-adrenoceptor agonists" RELATED [IUPHAR]
is_a: CHEBI:37886 ! adrenergic agonist
is_a: CHEBI:48539 ! alpha-adrenergic drug

[Term]
id: CHEBI:35604
name: carbon oxoanion
namespace: chebi_ontology
def: "A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n." []
subset: 3_STAR
synonym: "carbon oxoanion" EXACT [ChEBI]
synonym: "carbon oxoanions" RELATED [ChEBI]
synonym: "oxocarbon anion" RELATED [ChEBI]
synonym: "oxocarbon anions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:35406 ! oxoanion
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35605
name: carbon oxoacid
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbon oxoacids" RELATED [ChEBI]
synonym: "oxoacids of carbon" RELATED [ChEBI]
is_a: CHEBI:24833 ! oxoacid
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35620
name: vasodilator agent
namespace: chebi_ontology
def: "A drug used to cause dilation of the blood vessels." []
subset: 3_STAR
synonym: "vasodilator" RELATED [ChEBI]
synonym: "vasodilator agents" RELATED [ChEBI]
is_a: CHEBI:35554 ! cardiovascular drug

[Term]
id: CHEBI:35692
name: dicarboxylic acid
namespace: chebi_ontology
alt_id: CHEBI:23692
alt_id: CHEBI:36172
alt_id: CHEBI:4501
def: "Any carboxylic acid containing two carboxy groups." []
subset: 3_STAR
synonym: "Dicarboxylic acid" EXACT [KEGG_COMPOUND]
synonym: "dicarboxylic acids" RELATED [ChEBI]
xref: KEGG:C02028
is_a: CHEBI:131927 ! dicarboxylic acids and O-substituted derivatives
is_a: CHEBI:33575 ! carboxylic acid
relationship: is_conjugate_acid_of CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: CHEBI:35693
name: dicarboxylic acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "dicarboxylic acid anion" EXACT [ChEBI]
synonym: "dicarboxylic acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:35692 ! dicarboxylic acid

[Term]
id: CHEBI:35701
name: ester
namespace: chebi_ontology
alt_id: CHEBI:23960
alt_id: CHEBI:4859
def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." []
subset: 3_STAR
synonym: "Ester" EXACT [KEGG_COMPOUND]
synonym: "esters" RELATED [ChEBI]
xref: KEGG:C00287
xref: Wikipedia:Ester
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:35722
name: sulfated glycosaminoglycan
namespace: chebi_ontology
subset: 3_STAR
synonym: "glycosaminoglycan sulfate" RELATED [ChEBI]
synonym: "glycosaminoglycan sulfates" RELATED [ChEBI]
synonym: "sulfated glycosaminoglycans" RELATED [ChEBI]
is_a: CHEBI:18085 ! glycosaminoglycan
is_a: CHEBI:35724 ! carbohydrate sulfate

[Term]
id: CHEBI:35724
name: carbohydrate sulfate
namespace: chebi_ontology
subset: 3_STAR
synonym: "carbohydrate sulfates" RELATED [ChEBI]
synonym: "carbohydrate sulphates" RELATED [ChEBI]
is_a: CHEBI:25704 ! organic sulfate
is_a: CHEBI:26819 ! sulfuric ester
is_a: CHEBI:63299 ! carbohydrate derivative

[Term]
id: CHEBI:35757
name: monocarboxylic acid anion
namespace: chebi_ontology
alt_id: CHEBI:13657
alt_id: CHEBI:25382
alt_id: CHEBI:3407
def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." []
subset: 3_STAR
synonym: "a monocarboxylate" RELATED [UniProt]
synonym: "Carboxylate" RELATED [KEGG_COMPOUND]
synonym: "Monocarboxylate" RELATED [KEGG_COMPOUND]
synonym: "monocarboxylates" RELATED [ChEBI]
synonym: "monocarboxylic acid anions" RELATED [ChEBI]
xref: KEGG:C00060
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:25384 ! monocarboxylic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "44.01000" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "43.98983" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([*])=O" xsd:string

[Term]
id: CHEBI:35780
name: phosphate ion
namespace: chebi_ontology
def: "A phosphorus oxoanion that is the conjugate base of phosphoric acid." []
subset: 3_STAR
synonym: "phosphate" RELATED [ChEBI]
synonym: "phosphate ions" RELATED [ChEBI]
synonym: "Pi" RELATED [ChEBI]
is_a: CHEBI:33461 ! phosphorus oxoanion
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:26078 ! phosphoric acid

[Term]
id: CHEBI:35881
name: pnictogen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "pnictogen hydride" EXACT [ChEBI]
synonym: "pnictogen hydrides" RELATED [ChEBI]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33302 ! pnictogen molecular entity

[Term]
id: CHEBI:35942
name: neurotransmitter agent
namespace: chebi_ontology
def: "A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function." []
subset: 3_STAR
synonym: "neurotransmitter agents" RELATED [ChEBI]
is_a: CHEBI:23888 ! drug
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:36078
name: cholanoid
namespace: chebi_ontology
alt_id: CHEBI:22867
alt_id: CHEBI:50419
subset: 3_STAR
synonym: "bile acids and derivatives" RELATED [LIPID_MAPS]
synonym: "cholanoids" RELATED [ChEBI]
xref: LIPID_MAPS_class:LMST04 {source="LIPID MAPS"}
is_a: CHEBI:35341 ! steroid
relationship: has_parent_hydride CHEBI:35519 ! cholane

[Term]
id: CHEBI:36080
name: protein
namespace: chebi_ontology
alt_id: CHEBI:13677
alt_id: CHEBI:14911
def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." []
subset: 3_STAR
synonym: "proteins" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33695 ! information biomacromolecule
relationship: has_part CHEBI:16541 ! protein polypeptide chain

[Term]
id: CHEBI:36235
name: bile acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "bile acid anions" RELATED [ChEBI]
is_a: CHEBI:35757 ! monocarboxylic acid anion
is_a: CHEBI:50160 ! steroid acid anion

[Term]
id: CHEBI:36237
name: cholanic acid
namespace: chebi_ontology
def: "A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24." []
subset: 3_STAR
synonym: "cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC]
xref: CAS:25312-65-6 {source="ChemIDplus"}
xref: Patent:JP2008069152
xref: Reaxys:13246008 {source="Reaxys"}
is_a: CHEBI:36278 ! cholanic acids
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H40O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17?,18+,19-,20+,21+,23+,24-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RPKLZQLYODPWTM-KBMWBBLPSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "360.57320" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.30283" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O" xsd:string

[Term]
id: CHEBI:36238
name: 5beta-cholanic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "(5beta)-cholan-24-oic acid" RELATED [ChemIDplus]
synonym: "(5beta,17beta)-gamma-methylandrostane-17-butanoic acid" RELATED [ChemIDplus]
synonym: "5beta-cholan-24-oic acid" EXACT IUPAC_NAME [IUPAC]
synonym: "5beta-cholanic acid" EXACT [ChemIDplus]
synonym: "5beta-cholanoic acid" RELATED [ChemIDplus]
synonym: "ursocholanic acid" RELATED [ChemIDplus]
xref: Beilstein:3214794 {source="Beilstein"}
xref: CAS:546-18-9 {source="ChemIDplus"}
xref: LIPID_MAPS_instance:LMST04010441 {source="LIPID MAPS"}
is_a: CHEBI:36237 ! cholanic acid
is_a: CHEBI:36248 ! 5beta-cholanic acids
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C24H40O2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "RPKLZQLYODPWTM-LVVAJZGHSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "360.57320" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "360.30283" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCC(O)=O" xsd:string

[Term]
id: CHEBI:36248
name: 5beta-cholanic acids
namespace: chebi_ontology
def: "Members of the class of cholanic acids based on a 5beta-cholane skeleton." []
subset: 3_STAR
is_a: CHEBI:136889 ! 5beta steroid
is_a: CHEBI:36278 ! cholanic acids
relationship: has_parent_hydride CHEBI:20664 ! 5beta-cholane

[Term]
id: CHEBI:36277
name: bile acid salt
namespace: chebi_ontology
def: "A salt of a bile acid." []
subset: 3_STAR
synonym: "bile acid salts" RELATED [ChEBI]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:36078 ! cholanoid

[Term]
id: CHEBI:36278
name: cholanic acids
namespace: chebi_ontology
alt_id: CHEBI:23166
alt_id: CHEBI:23211
subset: 1_STAR
is_a: CHEBI:36078 ! cholanoid
is_a: CHEBI:47891 ! steroid acid

[Term]
id: CHEBI:36338
name: lepton
namespace: chebi_ontology
def: "Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin)." []
subset: 3_STAR
synonym: "leptons" RELATED [ChEBI]
is_a: CHEBI:33233 ! fundamental particle
is_a: CHEBI:36340 ! fermion

[Term]
id: CHEBI:36339
name: baryon
namespace: chebi_ontology
def: "Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy)." []
subset: 3_STAR
synonym: "baryons" RELATED [ChEBI]
is_a: CHEBI:36340 ! fermion
is_a: CHEBI:36344 ! hadron

[Term]
id: CHEBI:36340
name: fermion
namespace: chebi_ontology
def: "Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi." []
subset: 3_STAR
synonym: "fermion" EXACT IUPAC_NAME [IUPAC]
synonym: "fermions" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36341
name: boson
namespace: chebi_ontology
def: "Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose." []
subset: 3_STAR
synonym: "boson" EXACT IUPAC_NAME [IUPAC]
synonym: "bosons" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36342
name: subatomic particle
namespace: chebi_ontology
def: "A particle smaller than an atom." []
subset: 3_STAR
synonym: "subatomic particles" RELATED [ChEBI]
xref: Wikipedia:Subatomic_particle

[Term]
id: CHEBI:36343
name: composite particle
namespace: chebi_ontology
def: "A subatomic particle known to have substructure (i.e. consisting of smaller particles)." []
subset: 3_STAR
synonym: "composite particles" RELATED [ChEBI]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36344
name: hadron
namespace: chebi_ontology
def: "Hadron is a subatomic particle which experiences the strong force." []
subset: 3_STAR
synonym: "hadrons" RELATED [ChEBI]
is_a: CHEBI:36343 ! composite particle

[Term]
id: CHEBI:36347
name: nuclear particle
namespace: chebi_ontology
def: "A nucleus or any of its constituents in any of their energy states." []
subset: 3_STAR
synonym: "nuclear particle" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:36342 ! subatomic particle

[Term]
id: CHEBI:36357
name: polyatomic entity
namespace: chebi_ontology
def: "Any molecular entity consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic entities" RELATED [ChEBI]
is_a: CHEBI:23367 ! molecular entity
relationship: has_part CHEBI:24433 ! group

[Term]
id: CHEBI:36358
name: polyatomic ion
namespace: chebi_ontology
def: "An ion consisting of more than one atom." []
subset: 3_STAR
synonym: "polyatomic ions" RELATED [ChEBI]
is_a: CHEBI:24870 ! ion
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:36359
name: phosphorus oxoacid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "phosphorus oxoacid derivative" EXACT [ChEBI]
is_a: CHEBI:33241 ! oxoacid derivative
is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives
relationship: has_functional_parent CHEBI:33457 ! phosphorus oxoacid

[Term]
id: CHEBI:36360
name: phosphorus oxoacids and derivatives
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:26082 ! phosphorus molecular entity

[Term]
id: CHEBI:36586
name: carbonyl compound
namespace: chebi_ontology
def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." []
subset: 3_STAR
synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:36587 ! organic oxo compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23019 ! carbonyl group

[Term]
id: CHEBI:36587
name: organic oxo compound
namespace: chebi_ontology
def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." []
subset: 3_STAR
synonym: "organic oxo compounds" RELATED [ChEBI]
synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:72695 ! organic molecule
relationship: has_part CHEBI:46629 ! oxo group

[Term]
id: CHEBI:36735
name: biladienes
namespace: chebi_ontology
def: "Compounds based on a biladiene skeleton." []
subset: 3_STAR
is_a: CHEBI:25046 ! linear tetrapyrrole

[Term]
id: CHEBI:36902
name: chalcogen hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcogen hydride" EXACT [ChEBI]
synonym: "chalcogen hydrides" RELATED [ChEBI]
is_a: CHEBI:33242 ! inorganic hydride
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36914
name: inorganic ion
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic ions" RELATED [ChEBI]
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36915
name: inorganic cation
namespace: chebi_ontology
subset: 3_STAR
synonym: "inorganic cations" RELATED [ChEBI]
is_a: CHEBI:36914 ! inorganic ion
is_a: CHEBI:36916 ! cation

[Term]
id: CHEBI:36916
name: cation
namespace: chebi_ontology
alt_id: CHEBI:23058
alt_id: CHEBI:3473
def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." []
subset: 3_STAR
synonym: "Cation" EXACT [KEGG_COMPOUND]
synonym: "cation" EXACT IUPAC_NAME [IUPAC]
synonym: "cation" EXACT [ChEBI]
synonym: "cationes" RELATED [ChEBI]
synonym: "cations" RELATED [ChEBI]
synonym: "Kation" RELATED [ChEBI]
synonym: "Kationen" RELATED [ChEBI]
xref: KEGG:C01373
is_a: CHEBI:24870 ! ion

[Term]
id: CHEBI:36961
name: chalcocarbonic acid
namespace: chebi_ontology
subset: 3_STAR
synonym: "chalcocarbonic acid" EXACT [ChEBI]
synonym: "chalcocarbonic acids" EXACT IUPAC_NAME [IUPAC]
synonym: "chalcocarbonic acids" RELATED [ChEBI]
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:36962
name: organochalcogen compound
namespace: chebi_ontology
def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." []
subset: 3_STAR
synonym: "organochalcogen compound" EXACT [ChEBI]
synonym: "organochalcogen compounds" RELATED [ChEBI]
is_a: CHEBI:33285 ! heteroorganic entity
is_a: CHEBI:33304 ! chalcogen molecular entity

[Term]
id: CHEBI:36963
name: organooxygen compound
namespace: chebi_ontology
def: "An organochalcogen compound containing at least one carbon-oxygen bond." []
subset: 3_STAR
synonym: "organooxygen compound" EXACT [ChEBI]
synonym: "organooxygen compounds" RELATED [ChEBI]
xref: PMID:17586126 {source="Europe PMC"}
is_a: CHEBI:25806 ! oxygen molecular entity
is_a: CHEBI:36962 ! organochalcogen compound

[Term]
id: CHEBI:37022
name: amino-acid anion
namespace: chebi_ontology
subset: 3_STAR
synonym: "amino acid anions" RELATED [ChEBI]
synonym: "amino-acid anion" EXACT [ChEBI]
synonym: "amino-acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
is_a: CHEBI:35352 ! organonitrogen compound
relationship: is_conjugate_base_of CHEBI:33709 ! amino acid

[Term]
id: CHEBI:37163
name: glucan
namespace: chebi_ontology
alt_id: CHEBI:24255
alt_id: CHEBI:5392
def: "A polysaccharide composed of glucose residues." []
subset: 3_STAR
synonym: "Glucan" EXACT [KEGG_COMPOUND]
synonym: "glucan" EXACT IUPAC_NAME [IUPAC]
synonym: "glucans" RELATED [ChEBI]
xref: CAS:9037-91-6 {source="ChemIDplus"}
xref: KEGG:C01379
is_a: CHEBI:37164 ! homopolysaccharide
property_value: http://purl.obolibrary.org/obo/chebi/formula "C12H22O11(C6H10O5)n" xsd:string

[Term]
id: CHEBI:37164
name: homopolysaccharide
namespace: chebi_ontology
def: "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." []
subset: 3_STAR
synonym: "homoglycan" RELATED [IUPAC]
synonym: "homopolysaccharide" EXACT IUPAC_NAME [IUPAC]
synonym: "homopolysaccharides" RELATED [ChEBI]
is_a: CHEBI:18154 ! polysaccharide

[Term]
id: CHEBI:37175
name: organic hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic hydrides" RELATED [ChEBI]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37176
name: mononuclear parent hydride
namespace: chebi_ontology
subset: 3_STAR
synonym: "mononuclear hydride" RELATED [ChEBI]
synonym: "mononuclear hydrides" RELATED [IUPAC]
synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:33692 ! hydrides

[Term]
id: CHEBI:37246
name: elemental sodium
namespace: chebi_ontology
subset: 3_STAR
is_a: CHEBI:26712 ! sodium molecular entity

[Term]
id: CHEBI:37395
name: mucopolysaccharide
namespace: chebi_ontology
alt_id: CHEBI:25425
alt_id: CHEBI:7011
def: "Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid." []
subset: 3_STAR
synonym: "mucopolisacarido" RELATED [ChEBI]
synonym: "mucopolisacaridos" RELATED [IUPAC]
synonym: "Mucopolysaccharid" RELATED [ChEBI]
synonym: "Mucopolysaccharide" EXACT [KEGG_COMPOUND]
synonym: "mucopolysaccharides" EXACT IUPAC_NAME [IUPAC]
synonym: "Mukopolysaccharid" RELATED [ChEBI]
xref: KEGG:C05114
is_a: CHEBI:18085 ! glycosaminoglycan

[Term]
id: CHEBI:37527
name: acid
namespace: chebi_ontology
alt_id: CHEBI:13800
alt_id: CHEBI:13801
alt_id: CHEBI:22209
alt_id: CHEBI:2426
def: "An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid)." []
subset: 3_STAR
synonym: "Acid" EXACT [KEGG_COMPOUND]
synonym: "acid" EXACT IUPAC_NAME [IUPAC]
synonym: "acide" RELATED [IUPAC]
synonym: "acido" RELATED [ChEBI]
synonym: "acids" RELATED [ChEBI]
synonym: "Saeure" RELATED [ChEBI]
synonym: "Saeuren" RELATED [ChEBI]
xref: KEGG:C00174
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:37577
name: heteroatomic molecular entity
namespace: chebi_ontology
def: "A molecular entity consisting of two or more chemical elements." []
subset: 3_STAR
synonym: "chemical compound" RELATED [ChEBI]
synonym: "heteroatomic molecular entities" RELATED [ChEBI]
is_a: CHEBI:36357 ! polyatomic entity

[Term]
id: CHEBI:37622
name: carboxamide
namespace: chebi_ontology
alt_id: CHEBI:35354
alt_id: CHEBI:35355
def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." []
subset: 3_STAR
synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxamides" RELATED [ChEBI]
synonym: "primary carboxamide" RELATED [ChEBI]
is_a: CHEBI:33256 ! primary amide
is_a: CHEBI:35352 ! organonitrogen compound
is_a: CHEBI:36963 ! organooxygen compound
relationship: has_part CHEBI:23004 ! carbamoyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CNOR3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "42.01680" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "41.99799" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[*]C(=O)N([*])[*]" xsd:string

[Term]
id: CHEBI:37826
name: sulfuric acid derivative
namespace: chebi_ontology
subset: 3_STAR
synonym: "sulfuric acid derivative" EXACT [ChEBI]
synonym: "sulfuric acid derivatives" RELATED [ChEBI]
is_a: CHEBI:33424 ! sulfur oxoacid derivative
relationship: has_functional_parent CHEBI:26836 ! sulfuric acid

[Term]
id: CHEBI:37838
name: carboacyl group
namespace: chebi_ontology
def: "A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid." []
subset: 3_STAR
synonym: "carboacyl groups" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acyl group" EXACT IUPAC_NAME [IUPAC]
synonym: "carboxylic acyl groups" RELATED [IUPAC]
is_a: CHEBI:22221 ! acyl group
relationship: is_substituent_group_from CHEBI:33575 ! carboxylic acid

[Term]
id: CHEBI:37886
name: adrenergic agonist
namespace: chebi_ontology
def: "An agent that selectively binds to and activates adrenergic receptors." []
subset: 3_STAR
synonym: "adrenergic agonists" RELATED [ChEBI]
synonym: "adrenergic receptor agonist" RELATED [ChEBI]
synonym: "adrenoceptor agonists" RELATED [IUPHAR]
synonym: "adrenomimetic" RELATED [ChEBI]
synonym: "adrenomimetics" RELATED [ChEBI]
is_a: CHEBI:37962 ! adrenergic agent

[Term]
id: CHEBI:37962
name: adrenergic agent
namespace: chebi_ontology
def: "Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter." []
subset: 3_STAR
synonym: "adrenergic agents" RELATED [ChEBI]
synonym: "adrenergic drug" RELATED [ChEBI]
synonym: "adrenergic drugs" RELATED [ChEBI]
synonym: "adrenergic neuron agents" RELATED [ChEBI]
synonym: "adrenergics" RELATED [ChEBI]
is_a: CHEBI:35942 ! neurotransmitter agent

[Term]
id: CHEBI:38077
name: polypyrrole
namespace: chebi_ontology
def: "A compound composed of two or more pyrrole units." []
subset: 3_STAR
synonym: "poly(pyrrole)s" RELATED [ChEBI]
synonym: "polypyrroles" RELATED [ChEBI]
synonym: "PPys" RELATED [ChEBI]
xref: Beilstein:8538310 {source="Beilstein"}
is_a: CHEBI:38101 ! organonitrogen heterocyclic compound

[Term]
id: CHEBI:38101
name: organonitrogen heterocyclic compound
namespace: chebi_ontology
def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." []
subset: 3_STAR
synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI]
synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:35352 ! organonitrogen compound

[Term]
id: CHEBI:38166
name: organic heteropolycyclic compound
namespace: chebi_ontology
alt_id: CHEBI:25429
alt_id: CHEBI:38075
subset: 3_STAR
synonym: "organic heteropolycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:24532 ! organic heterocyclic compound
is_a: CHEBI:33671 ! heteropolycyclic compound

[Term]
id: CHEBI:38180
name: polycyclic heteroarene
namespace: chebi_ontology
subset: 3_STAR
synonym: "polycyclic heteroarenes" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene

[Term]
id: CHEBI:38323
name: cholinergic drug
namespace: chebi_ontology
def: "Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons." []
subset: 3_STAR
synonym: "cholinergic agent" RELATED [ChEBI]
synonym: "cholinergic drugs" RELATED [ChEBI]
synonym: "cholinomimetic" RELATED [ChEBI]
is_a: CHEBI:35942 ! neurotransmitter agent

[Term]
id: CHEBI:38324
name: cholinergic agonist
namespace: chebi_ontology
def: "Any drug that binds to and activates cholinergic receptors." []
subset: 3_STAR
synonym: "acetylcholine agonist" RELATED [ChEBI]
synonym: "acetylcholine agonists" RELATED [ChEBI]
synonym: "acetylcholine receptor agonist" RELATED [IUPHAR]
synonym: "cholinergic agonists" RELATED [ChEBI]
synonym: "cholinomimetic" RELATED [ChEBI]
synonym: "cholinomimetics" RELATED [ChEBI]
is_a: CHEBI:38323 ! cholinergic drug

[Term]
id: CHEBI:38325
name: muscarinic agonist
namespace: chebi_ontology
def: "Any drug that binds to and activates a muscarinic cholinergic receptor." []
subset: 3_STAR
synonym: "muscarinic acetylcholine receptor agonist" RELATED [ChEBI]
synonym: "muscarinic agonists" RELATED [ChEBI]
synonym: "muscarinic cholinergic agonist" RELATED [ChEBI]
synonym: "muscarinic cholinergic agonists" RELATED [ChEBI]
is_a: CHEBI:38324 ! cholinergic agonist

[Term]
id: CHEBI:38631
name: aminoalkylindole
namespace: chebi_ontology
alt_id: CHEBI:22503
alt_id: CHEBI:24792
subset: 3_STAR
synonym: "aminoalkylindoles" RELATED [ChEBI]
is_a: CHEBI:24828 ! indoles

[Term]
id: CHEBI:38700
name: organic sodium salt
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic sodium salt" EXACT [ChEBI]
synonym: "organic sodium salts" RELATED [ChEBI]
is_a: CHEBI:24868 ! organic salt
is_a: CHEBI:26714 ! sodium salt

[Term]
id: CHEBI:38716
name: carboxylic acid dianion
namespace: chebi_ontology
def: "Any dianion containing at least one carboxy group." []
subset: 3_STAR
synonym: "carboxylic acid dianion" EXACT [ChEBI]
synonym: "carboxylic acid dianions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion

[Term]
id: CHEBI:38958
name: indole alkaloid
namespace: chebi_ontology
alt_id: CHEBI:24795
alt_id: CHEBI:5901
def: "An alkaloid containing an indole skeleton." []
subset: 3_STAR
synonym: "Indole alkaloid" EXACT [KEGG_COMPOUND]
synonym: "indole alkaloids" RELATED [ChEBI]
xref: KEGG:C06073
xref: Wikipedia:Indole_alkaloid
is_a: CHEBI:22315 ! alkaloid
relationship: has_part CHEBI:73398 ! indole skeleton

[Term]
id: CHEBI:39141
name: Bronsted acid
namespace: chebi_ontology
def: "A molecular entity capable of donating a hydron to an acceptor (Bronsted base)." []
subset: 3_STAR
synonym: "acide de Bronsted" RELATED [IUPAC]
synonym: "Bronsted acid" EXACT IUPAC_NAME [IUPAC]
synonym: "Bronsted-Saeure" RELATED [ChEBI]
synonym: "donneur d'hydron" RELATED [IUPAC]
synonym: "hydron donor" RELATED [IUPAC]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:37527 ! acid

[Term]
id: CHEBI:39142
name: Bronsted base
namespace: chebi_ontology
def: "A molecular entity capable of accepting a hydron from a donor (Bronsted acid)." []
subset: 3_STAR
synonym: "accepteur d'hydron" RELATED [IUPAC]
synonym: "base de Bronsted" RELATED [IUPAC]
synonym: "Bronsted base" EXACT IUPAC_NAME [IUPAC]
synonym: "Bronsted-Base" RELATED [ChEBI]
synonym: "hydron acceptor" RELATED [IUPAC]
is_a: CHEBI:15339 ! acceptor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39144
name: Lewis base
namespace: chebi_ontology
def: "A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct." []
subset: 3_STAR
synonym: "base de Lewis" RELATED [IUPAC]
synonym: "donneur d'une paire d'electrons" RELATED [ChEBI]
synonym: "electron donor" RELATED [ChEBI]
synonym: "Lewis base" EXACT IUPAC_NAME [IUPAC]
synonym: "Lewis-Base" RELATED [ChEBI]
is_a: CHEBI:17891 ! donor
is_a: CHEBI:22695 ! base

[Term]
id: CHEBI:39745
name: dihydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29137
alt_id: CHEBI:39739
def: "A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated." []
subset: 3_STAR
synonym: "[PO2(OH)2](-)" RELATED [IUPAC]
synonym: "dihydrogen(tetraoxidophosphate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydrogenphosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "DIHYDROGENPHOSPHATE ION" RELATED [PDBeChem]
synonym: "dihydrogentetraoxophosphate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
synonym: "dihydroxidodioxidophosphate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "H2PO4(-)" RELATED [IUPAC]
xref: DrugBank:DB02831
xref: Gmelin:1999 {source="Gmelin"}
xref: PDBeChem:2HP
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79389 ! monovalent inorganic anion
relationship: is_conjugate_acid_of CHEBI:43474 ! hydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H2O4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.98724" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96962" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OP([O-])(=O)O[H]" xsd:string

[Term]
id: CHEBI:41609
name: carbonate
namespace: chebi_ontology
alt_id: CHEBI:29201
alt_id: CHEBI:41605
subset: 3_STAR
synonym: "[CO3](2-)" RELATED [IUPAC]
synonym: "carbonate" EXACT [IUPAC]
synonym: "CARBONATE ION" RELATED [PDBeChem]
synonym: "CO3(2-)" RELATED [ChEBI]
synonym: "Karbonat" RELATED [ChEBI]
synonym: "trioxidocarbonate(2-)" EXACT IUPAC_NAME [IUPAC]
xref: Beilstein:3600898 {source="Beilstein"}
xref: CAS:3812-32-6 {source="ChemIDplus"}
xref: Gmelin:1559 {source="Gmelin"}
xref: PDBeChem:CO3
is_a: CHEBI:35604 ! carbon oxoanion
relationship: is_conjugate_base_of CHEBI:17544 ! hydrogencarbonate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BVKZGUZCCUSVTD-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "60.00890" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.98584" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]C([O-])=O" xsd:string

[Term]
id: CHEBI:43176
name: hydroxy group
namespace: chebi_ontology
alt_id: CHEBI:24706
alt_id: CHEBI:43171
subset: 3_STAR
synonym: "-OH" RELATED [IUPAC]
synonym: "hydroxy" EXACT IUPAC_NAME [IUPAC]
synonym: "HYDROXY GROUP" EXACT [PDBeChem]
synonym: "hydroxy group" EXACT [UniProt]
synonym: "hydroxyl" RELATED [ChEBI]
synonym: "hydroxyl group" RELATED [ChEBI]
xref: PDBeChem:OH
is_a: CHEBI:33246 ! inorganic group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.00734" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.00274" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*O[H]" xsd:string

[Term]
id: CHEBI:43474
name: hydrogenphosphate
namespace: chebi_ontology
alt_id: CHEBI:29139
alt_id: CHEBI:43470
def: "A phosphate ion that is the conjugate base of dihydrogenphosphate." []
subset: 3_STAR
synonym: "[P(OH)O3](2-)" RELATED [MolBase]
synonym: "[PO3(OH)](2-)" RELATED [IUPAC]
synonym: "HPO4(2-)" RELATED [IUPAC]
synonym: "hydrogen phosphate" RELATED [ChEBI]
synonym: "hydrogen(tetraoxidophosphate)(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogenphosphate" EXACT IUPAC_NAME [IUPAC]
synonym: "HYDROGENPHOSPHATE ION" RELATED [PDBeChem]
synonym: "hydrogentetraoxophosphate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxophosphate(V)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidotrioxidophosphate(2-)" EXACT IUPAC_NAME [IUPAC]
synonym: "INORGANIC PHOSPHATE GROUP" RELATED [PDBeChem]
synonym: "phosphate" RELATED [UniProt]
xref: Gmelin:1998 {source="Gmelin"}
xref: MolBase:1628
xref: PDBeChem:PI
xref: PDBeChem:PO4
is_a: CHEBI:35780 ! phosphate ion
is_a: CHEBI:79388 ! divalent inorganic anion
relationship: has_role CHEBI:23357 ! cofactor
relationship: has_role CHEBI:75772 ! Saccharomyces cerevisiae metabolite
relationship: is_conjugate_acid_of CHEBI:18367 ! phosphate(3-)
relationship: is_conjugate_base_of CHEBI:39745 ! dihydrogenphosphate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4P" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NBIIXXVUZAFLBC-UHFFFAOYSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "95.97930" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.96234" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "OP([O-])([O-])=O" xsd:string

[Term]
id: CHEBI:45696
name: hydrogensulfate
namespace: chebi_ontology
alt_id: CHEBI:29199
alt_id: CHEBI:45693
subset: 3_STAR
synonym: "[SO3(OH)](-)" RELATED [IUPAC]
synonym: "HSO4(-)" RELATED [IUPAC]
synonym: "HYDROGEN SULFATE" RELATED [PDBeChem]
synonym: "hydrogen(tetraoxidosulfate)(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogensulfate" EXACT [IUPAC]
synonym: "hydrogensulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogentetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC]
synonym: "hydroxidotrioxidosulfate(1-)" EXACT IUPAC_NAME [IUPAC]
xref: Gmelin:2121 {source="Gmelin"}
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: is_conjugate_acid_of CHEBI:16189 ! sulfate
relationship: is_conjugate_base_of CHEBI:26836 ! sulfuric acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "HO4S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "QAOWNCQODCNURD-UHFFFAOYSA-M" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "97.07154" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "96.96010" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]OS([O-])(=O)=O" xsd:string

[Term]
id: CHEBI:46629
name: oxo group
namespace: chebi_ontology
alt_id: CHEBI:29353
alt_id: CHEBI:44607
subset: 3_STAR
synonym: "=O" RELATED [IUPAC]
synonym: "oxo" EXACT IUPAC_NAME [IUPAC]
synonym: "OXO GROUP" EXACT [PDBeChem]
xref: PDBeChem:O
is_a: CHEBI:33246 ! inorganic group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "15.99940" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "15.99491" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "O=*" xsd:string

[Term]
id: CHEBI:46787
name: solvent
namespace: chebi_ontology
def: "A liquid that can dissolve other substances (solutes) without any change in their chemical composition." []
subset: 3_STAR
synonym: "Loesungsmittel" RELATED [ChEBI]
synonym: "solvant" RELATED [ChEBI]
synonym: "solvents" RELATED [ChEBI]
xref: Wikipedia:Solvent
is_a: CHEBI:33232 ! application
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:46883
name: carboxy group
namespace: chebi_ontology
alt_id: CHEBI:23025
alt_id: CHEBI:41420
subset: 3_STAR
synonym: "-C(O)OH" RELATED [IUPAC]
synonym: "-CO2H" RELATED [ChEBI]
synonym: "-COOH" RELATED [IUPAC]
synonym: "carboxy" EXACT IUPAC_NAME [IUPAC]
synonym: "CARBOXY GROUP" EXACT [PDBeChem]
synonym: "carboxyl group" RELATED [ChEBI]
xref: PDBeChem:FMT
is_a: CHEBI:33249 ! organyl group
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "CHO2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "45.01744" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "44.99765" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "*C(=O)O" xsd:string

[Term]
id: CHEBI:47622
name: acetate ester
namespace: chebi_ontology
alt_id: CHEBI:13244
alt_id: CHEBI:13799
alt_id: CHEBI:22189
alt_id: CHEBI:2406
def: "Any carboxylic ester where the carboxylic acid component is acetic acid." []
subset: 3_STAR
synonym: "acetate" RELATED [ChEBI]
synonym: "acetate esters" RELATED [ChEBI]
synonym: "acetates" RELATED [ChEBI]
synonym: "Acetic ester" RELATED [KEGG_COMPOUND]
synonym: "Acetyl ester" RELATED [KEGG_COMPOUND]
synonym: "acetyl esters" RELATED [ChEBI]
synonym: "an acetyl ester" RELATED [UniProt]
xref: KEGG:C01883
xref: Wikipedia:Acetate#Esters
is_a: CHEBI:33308 ! carboxylic ester
relationship: has_functional_parent CHEBI:15366 ! acetic acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H3O2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "59.04400" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "59.01330" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC(=O)O[*]" xsd:string

[Term]
id: CHEBI:47891
name: steroid acid
namespace: chebi_ontology
def: "Any steroid substituted by at least one carboxy group." []
subset: 3_STAR
synonym: "steroid acids" RELATED [ChEBI]
is_a: CHEBI:35341 ! steroid
is_a: CHEBI:64709 ! organic acid
relationship: is_conjugate_acid_of CHEBI:50160 ! steroid acid anion

[Term]
id: CHEBI:48154
name: sulfur oxide
namespace: chebi_ontology
subset: 3_STAR
synonym: "oxides of sulfur" RELATED [ChEBI]
synonym: "Schwefeloxide" RELATED [ChEBI]
synonym: "sulfur oxides" RELATED [ChEBI]
is_a: CHEBI:24836 ! inorganic oxide
is_a: CHEBI:26835 ! sulfur molecular entity

[Term]
id: CHEBI:48354
name: polar solvent
namespace: chebi_ontology
def: "A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds." []
subset: 3_STAR
synonym: "polar solvent" EXACT IUPAC_NAME [IUPAC]
synonym: "polar solvents" RELATED [ChEBI]
is_a: CHEBI:46787 ! solvent

[Term]
id: CHEBI:48356
name: protic solvent
namespace: chebi_ontology
def: "A polar solvent that is capable of acting as a hydron (proton) donor." []
subset: 3_STAR
synonym: "protogenic solvent" EXACT IUPAC_NAME [IUPAC]
is_a: CHEBI:39141 ! Bronsted acid
is_a: CHEBI:48354 ! polar solvent

[Term]
id: CHEBI:48539
name: alpha-adrenergic drug
namespace: chebi_ontology
def: "Any drug that acts on an alpha-adrenergic receptor." []
subset: 3_STAR
synonym: "alpha-adrenergic drugs" RELATED [ChEBI]
is_a: CHEBI:37962 ! adrenergic agent

[Term]
id: CHEBI:48705
name: agonist
namespace: chebi_ontology
def: "Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own." []
subset: 3_STAR
synonym: "agonist" EXACT IUPAC_NAME [IUPAC]
synonym: "agonista" RELATED [ChEBI]
synonym: "agoniste" RELATED [ChEBI]
synonym: "agonists" RELATED [ChEBI]
is_a: CHEBI:52210 ! pharmacological role

[Term]
id: CHEBI:49637
name: hydrogen atom
namespace: chebi_ontology
alt_id: CHEBI:24634
alt_id: CHEBI:49636
subset: 3_STAR
synonym: "1H" RELATED [IUPAC]
synonym: "H" RELATED [IUPAC]
synonym: "hidrogeno" RELATED [ChEBI]
synonym: "hydrogen" EXACT IUPAC_NAME [IUPAC]
synonym: "hydrogen" RELATED [ChEBI]
synonym: "hydrogene" RELATED [ChEBI]
synonym: "Wasserstoff" RELATED [ChEBI]
xref: WebElements:H
is_a: CHEBI:24835 ! inorganic molecular entity
is_a: CHEBI:25585 ! nonmetal atom
is_a: CHEBI:33559 ! s-block element atom
relationship: has_role CHEBI:33937 ! macronutrient
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/H" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "YZCKVEUIGOORGS-UHFFFAOYSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1.00794" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1.00783" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[H]" xsd:string

[Term]
id: CHEBI:50047
name: organic amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." []
subset: 3_STAR
synonym: "organic amino compounds" RELATED [ChEBI]
is_a: CHEBI:35352 ! organonitrogen compound
relationship: has_parent_hydride CHEBI:16134 ! ammonia
relationship: has_role CHEBI:39142 ! Bronsted base

[Term]
id: CHEBI:50160
name: steroid acid anion
namespace: chebi_ontology
def: "Any anion formed by loss of a proton from a steroid acid." []
subset: 3_STAR
synonym: "steroid acid anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: is_conjugate_base_of CHEBI:47891 ! steroid acid

[Term]
id: CHEBI:50297
name: canonical nucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50319 ! nucleotide residue

[Term]
id: CHEBI:50298
name: canonical deoxyribonucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical deoxyribonucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50297 ! canonical nucleotide residue

[Term]
id: CHEBI:50299
name: canonical ribonucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "canonical ribonucleotide residues" RELATED [ChEBI]
is_a: CHEBI:50297 ! canonical nucleotide residue

[Term]
id: CHEBI:50312
name: onium compound
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:37577 ! heteroatomic molecular entity

[Term]
id: CHEBI:50313
name: onium cation
namespace: chebi_ontology
def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." []
subset: 3_STAR
synonym: "onium cations" EXACT IUPAC_NAME [IUPAC]
synonym: "onium cations" RELATED [ChEBI]
synonym: "onium ion" RELATED [ChEBI]
synonym: "onium ions" RELATED [ChEBI]
is_a: CHEBI:50312 ! onium compound

[Term]
id: CHEBI:50319
name: nucleotide residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "nucleotide residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50320
name: nucleoside residue
namespace: chebi_ontology
subset: 3_STAR
synonym: "nucleoside residues" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:50514
name: vasoconstrictor agent
namespace: chebi_ontology
def: "Drug used to cause constriction of the blood vessels." []
subset: 3_STAR
is_a: CHEBI:35554 ! cardiovascular drug

[Term]
id: CHEBI:50860
name: organic molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25700
alt_id: CHEBI:33244
def: "Any molecular entity that contains carbon." []
subset: 3_STAR
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic entity" RELATED [ChEBI]
synonym: "organic molecular entities" RELATED [ChEBI]
is_a: CHEBI:33582 ! carbon group molecular entity
relationship: has_part CHEBI:27594 ! carbon atom

[Term]
id: CHEBI:50906
name: role
namespace: chebi_ontology
def: "A role is particular behaviour which a material entity may exhibit." []
subset: 3_STAR
is_a: PATO:0000001 ! quality

[Term]
id: CHEBI:50910
name: neurotoxin
namespace: chebi_ontology
alt_id: CHEBI:50911
def: "A poison that interferes with the functions of the nervous system." []
subset: 3_STAR
synonym: "agente neurotoxico" RELATED [ChEBI]
synonym: "nerve poison" RELATED [ChEBI]
synonym: "nerve poisons" RELATED [ChEBI]
synonym: "neurotoxic agent" RELATED [ChEBI]
synonym: "neurotoxic agents" RELATED [ChEBI]
synonym: "neurotoxicant" RELATED [ChEBI]
synonym: "neurotoxins" RELATED [ChEBI]
xref: Wikipedia:Neurotoxin
is_a: CHEBI:52209 ! aetiopathogenetic role
is_a: CHEBI:64909 ! poison

[Term]
id: CHEBI:50994
name: primary amino compound
namespace: chebi_ontology
def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." []
subset: 3_STAR
synonym: "primary amino compounds" RELATED [ChEBI]
is_a: CHEBI:50047 ! organic amino compound
relationship: is_conjugate_base_of CHEBI:65296 ! primary ammonium ion

[Term]
id: CHEBI:51086
name: chemical role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof within a chemical context." []
subset: 3_STAR
is_a: CHEBI:50906 ! role

[Term]
id: CHEBI:51143
name: nitrogen molecular entity
namespace: chebi_ontology
alt_id: CHEBI:25556
alt_id: CHEBI:7594
subset: 3_STAR
synonym: "nitrogen compounds" RELATED [ChEBI]
synonym: "nitrogen molecular entities" RELATED [ChEBI]
synonym: "Nitrogenous compounds" RELATED [KEGG_COMPOUND]
xref: KEGG:C06061
is_a: CHEBI:33302 ! pnictogen molecular entity
relationship: has_part CHEBI:25555 ! nitrogen atom

[Term]
id: CHEBI:51151
name: dipolar compound
namespace: chebi_ontology
def: "An  organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." []
subset: 3_STAR
synonym: "dipolar compounds" RELATED [ChEBI]
is_a: CHEBI:72695 ! organic molecule

[Term]
id: CHEBI:51422
name: organodiyl group
namespace: chebi_ontology
def: "Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s)." []
subset: 3_STAR
synonym: "organodiyl groups" RELATED [ChEBI]
is_a: CHEBI:51446 ! organic divalent group

[Term]
id: CHEBI:51446
name: organic divalent group
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51447
name: organic univalent group
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:51958
name: organic polycyclic compound
namespace: chebi_ontology
subset: 3_STAR
synonym: "organic polycyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33635 ! polycyclic compound
is_a: CHEBI:33832 ! organic cyclic compound

[Term]
id: CHEBI:52206
name: biochemical role
namespace: chebi_ontology
def: "A biological role played by the molecular entity or part thereof within a biochemical context." []
subset: 3_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52209
name: aetiopathogenetic role
namespace: chebi_ontology
def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." []
subset: 3_STAR
synonym: "etiopathogenetic agent" RELATED [ChEBI]
synonym: "etiopathogenetic role" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52210
name: pharmacological role
namespace: chebi_ontology
def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." []
subset: 3_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52211
name: physiological role
namespace: chebi_ontology
subset: 1_STAR
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:52217
name: pharmaceutical
namespace: chebi_ontology
alt_id: CHEBI:33293
alt_id: CHEBI:33294
def: "Any substance introduced into a living organism with therapeutic or diagnostic purpose." []
subset: 3_STAR
synonym: "farmaco" RELATED [ChEBI]
synonym: "medicament" RELATED [ChEBI]
synonym: "pharmaceuticals" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:52845
name: cyclic organic group
namespace: chebi_ontology
def: "An organic group that consists of a closed ring. It may be a substituent or a skeleton." []
subset: 3_STAR
synonym: "cyclic organic groups" RELATED [ChEBI]
is_a: CHEBI:33247 ! organic group

[Term]
id: CHEBI:53000
name: epitope
namespace: chebi_ontology
def: "The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds." []
subset: 3_STAR
synonym: "antigenic determinant" RELATED [ChEBI]
synonym: "epitope function" RELATED [ChEBI]
synonym: "epitope role" RELATED [ChEBI]
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:53309
name: polyanionic macromolecule
namespace: chebi_ontology
def: "A polymer carrying multiple negative charges." []
subset: 3_STAR
synonym: "polyanion" RELATED [ChEBI]
synonym: "polyanions" RELATED [SUBMITTER]
is_a: CHEBI:53368 ! ionic macromolecule

[Term]
id: CHEBI:53368
name: ionic macromolecule
namespace: chebi_ontology
def: "A macromolecule containing ionic groups." []
subset: 3_STAR
synonym: "ionic polymer" RELATED [ChEBI]
synonym: "polyionic macromolecule" RELATED [ChEBI]
is_a: CHEBI:33839 ! macromolecule

[Term]
id: CHEBI:5391
name: glucagon
namespace: chebi_ontology
def: "A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence." []
subset: 3_STAR
synonym: "Glucagon" EXACT [KEGG_COMPOUND]
synonym: "glucagon" RELATED INN [ChemIDplus]
synonym: "Glucagone" RELATED [ChemIDplus]
synonym: "glucagonum" RELATED INN [ChemIDplus]
synonym: "His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr" RELATED [ChEBI]
synonym: "His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr" RELATED [ChemIDplus]
synonym: "HSQGTFTSDYSKYLDSRRAQDFVQWLMNT" RELATED [ChEBI]
synonym: "L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine" EXACT IUPAC_NAME [IUPAC]
xref: CAS:16941-32-5 {source="ChemIDplus"}
xref: CAS:9007-92-5 {source="KEGG COMPOUND"}
xref: CAS:9007-92-5 {source="ChemIDplus"}
xref: Drug_Central:2994 {source="DrugCentral"}
xref: DrugBank:DB00040
xref: KEGG:C01501
xref: KEGG:D00116
xref: PMID:21940356 {source="Europe PMC"}
xref: PMID:22014161 {source="Europe PMC"}
xref: PMID:22154917 {source="Europe PMC"}
xref: PMID:22166985 {source="Europe PMC"}
xref: PMID:22167521 {source="Europe PMC"}
xref: PMID:22214853 {source="Europe PMC"}
xref: PMID:22227186 {source="Europe PMC"}
xref: PMID:22286080 {source="Europe PMC"}
xref: PMID:22294753 {source="Europe PMC"}
xref: PMID:22318544 {source="Europe PMC"}
xref: PMID:22334714 {source="Europe PMC"}
xref: PMID:22399501 {source="Europe PMC"}
xref: PMID:22438981 {source="Europe PMC"}
xref: PMID:22454291 {source="Europe PMC"}
xref: Reaxys:13191924 {source="Reaxys"}
xref: Wikipedia:Glucagon
is_a: CHEBI:25905 ! peptide hormone
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C153H225N43O49S" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "MASNOZXLGMXCHN-ZLPAWPGGSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "3482.74700" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "3480.61570" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O" xsd:string

[Term]
id: CHEBI:5686
name: heterocyclic compound
namespace: chebi_ontology
def: "A cyclic compound having as ring members atoms of at least two different elements." []
subset: 3_STAR
synonym: "compuesto heterociclico" RELATED [IUPAC]
synonym: "compuestos heterociclicos" RELATED [IUPAC]
synonym: "heterocycle" RELATED [ChEBI]
synonym: "Heterocyclic compound" EXACT [KEGG_COMPOUND]
synonym: "heterocyclic compounds" RELATED [ChEBI]
is_a: CHEBI:33595 ! cyclic compound

[Term]
id: CHEBI:57887
name: tryptaminium
namespace: chebi_ontology
def: "An  ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3." []
subset: 3_STAR
synonym: "2-(1H-indol-3-yl)ethanaminium" EXACT IUPAC_NAME [IUPAC]
synonym: "tryptamine" RELATED [UniProt]
synonym: "tryptaminium cation" RELATED [ChEBI]
synonym: "tryptaminium(1+)" RELATED [ChEBI]
xref: Gmelin:533978 {source="Gmelin"}
is_a: CHEBI:65296 ! primary ammonium ion
relationship: has_role CHEBI:75771 ! mouse metabolite
relationship: has_role CHEBI:76924 ! plant metabolite
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:16765 ! tryptamine
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C10H13N2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2/p+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "APJYDQYYACXCRM-UHFFFAOYSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "161.22310" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "161.10732" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]CCc1c[nH]c2ccccc12" xsd:string

[Term]
id: CHEBI:57977
name: bilirubin(2-)
namespace: chebi_ontology
def: "A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3." []
subset: 3_STAR
synonym: "2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate" RELATED [ChEBI]
synonym: "bilirubin dianion" RELATED [ChEBI]
synonym: "bilirubin IXalpha" RELATED [UniProt]
xref: Beilstein:4083310 {source="Beilstein"}
is_a: CHEBI:28965 ! dicarboxylic acid dianion
is_a: CHEBI:59252 ! linear tetrapyrrole anion
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_base_of CHEBI:16990 ! bilirubin IXalpha
property_value: http://purl.obolibrary.org/obo/chebi/charge "-2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C33H34N4O6" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "BPYKTIZUTYGOLE-IFADSCNNSA-L" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "582.64630" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "582.24893" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "CC1=C(C=C)\\C(NC1=O)=C\\c1[nH]c(Cc2[nH]c(\\C=C3NC(=O)C(C=C)=C/3C)c(C)c2CCC([O-])=O)c(CCC([O-])=O)c1C" xsd:string

[Term]
id: CHEBI:58958
name: organosulfate oxoanion
namespace: chebi_ontology
def: "An organic anion of general formula RS(=O)2O(-) where R is an organyl group." []
subset: 3_STAR
synonym: "organosulfate oxoanions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion
is_a: CHEBI:33482 ! sulfur oxoanion
relationship: has_functional_parent CHEBI:16189 ! sulfate
relationship: is_conjugate_base_of CHEBI:25704 ! organic sulfate
property_value: http://purl.obolibrary.org/obo/chebi/charge "-1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "O4SR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "96.06300" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "95.95173" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[O-]S(=O)(=O)O[*]" xsd:string

[Term]
id: CHEBI:59252
name: linear tetrapyrrole anion
namespace: chebi_ontology
def: "An organic anion arising from deprotonation of a acyclic tetrapyrrole compound." []
subset: 3_STAR
synonym: "acyclic tetrapyrrole anion" RELATED [ChEBI]
synonym: "acyclic tetrapyrrole anions" RELATED [ChEBI]
synonym: "linear tetrapyrrole anions" RELATED [ChEBI]
is_a: CHEBI:25696 ! organic anion

[Term]
id: CHEBI:59698
name: phosphoric acids
namespace: chebi_ontology
def: "Compounds containing one or more phosphoric acid units." []
subset: 3_STAR
is_a: CHEBI:33457 ! phosphorus oxoacid

[Term]
id: CHEBI:59740
name: nucleophilic reagent
namespace: chebi_ontology
def: "A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons." []
subset: 3_STAR
synonym: "nucleophile" RELATED [ChEBI]
synonym: "nucleophiles" RELATED [ChEBI]
synonym: "nucleophilic reagents" RELATED [ChEBI]
is_a: CHEBI:33893 ! reagent
is_a: CHEBI:39144 ! Lewis base

[Term]
id: CHEBI:59999
name: chemical substance
namespace: chebi_ontology
def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." []
subset: 3_STAR
synonym: "Chemische Substanz" RELATED [ChEBI]
is_a: CHEBI:24431 ! chemical entity

[Term]
id: CHEBI:60004
name: mixture
namespace: chebi_ontology
def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." []
subset: 3_STAR
synonym: "Mischung" RELATED [ChEBI]
is_a: CHEBI:59999 ! chemical substance

[Term]
id: CHEBI:60027
name: polymer
namespace: chebi_ontology
def: "A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.." []
subset: 3_STAR
synonym: "Kunststoff" RELATED [ChEBI]
synonym: "Polymer" EXACT [ChEBI]
xref: Wikipedia:Polymer
is_a: CHEBI:60004 ! mixture
relationship: has_part CHEBI:33839 ! macromolecule

[Term]
id: CHEBI:60164
name: ionic polymer
namespace: chebi_ontology
def: "An ionic polymer is a polymer, composed of ionic macromolecules." []
subset: 3_STAR
synonym: "polyionic polymer" RELATED [ChEBI]
is_a: CHEBI:60027 ! polymer
relationship: has_part CHEBI:53368 ! ionic macromolecule

[Term]
id: CHEBI:60242
name: monovalent inorganic cation
namespace: chebi_ontology
def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." []
subset: 3_STAR
synonym: "a monovalent cation" RELATED [UniProt]
is_a: CHEBI:36915 ! inorganic cation

[Term]
id: CHEBI:60466
name: peptide zwitterion
namespace: chebi_ontology
def: "Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged." []
subset: 3_STAR
synonym: "a peptide" RELATED [UniProt]
synonym: "peptide zwitterions" RELATED [ChEBI]
is_a: CHEBI:27369 ! zwitterion
relationship: is_tautomer_of CHEBI:16670 ! peptide
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R(C2H2NOR)n" xsd:string

[Term]
id: CHEBI:60926
name: amino monosaccharide
namespace: chebi_ontology
def: "Any  amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group." []
subset: 3_STAR
synonym: "amino monosaccharides" RELATED [ChEBI]
is_a: CHEBI:28963 ! amino sugar

[Term]
id: CHEBI:61120
name: nucleobase-containing molecular entity
namespace: chebi_ontology
def: "Any compound that has a nucleobase as a part." []
subset: 3_STAR
synonym: "nucleobase-containing compound" RELATED [SUBMITTER]
synonym: "nucleobase-containing compounds" RELATED [ChEBI]
synonym: "nucleobase-containing molecular entities" RELATED [ChEBI]
is_a: CHEBI:33833 ! heteroarene
is_a: CHEBI:51143 ! nitrogen molecular entity
relationship: has_functional_parent CHEBI:18282 ! nucleobase

[Term]
id: CHEBI:61469
name: polyanionic polymer
namespace: chebi_ontology
def: "A polymer, composed of polyanion macromolecules." []
subset: 3_STAR
synonym: "polyanion" RELATED [ChEBI]
synonym: "polyanions" RELATED [ChEBI]
is_a: CHEBI:60164 ! ionic polymer
relationship: has_part CHEBI:53309 ! polyanionic macromolecule

[Term]
id: CHEBI:63248
name: oxidising agent
namespace: chebi_ontology
def: "A substance that removes electrons from another reactant in a redox reaction." []
subset: 3_STAR
synonym: "oxidant" RELATED [ChEBI]
synonym: "oxidants" RELATED [ChEBI]
synonym: "oxidiser" RELATED [ChEBI]
synonym: "oxidisers" RELATED [ChEBI]
synonym: "oxidising agents" RELATED [ChEBI]
synonym: "oxidizer" RELATED [ChEBI]
synonym: "oxidizers" RELATED [ChEBI]
synonym: "oxidizing agent" RELATED [ChEBI]
synonym: "oxidizing agents" RELATED [ChEBI]
is_a: CHEBI:51086 ! chemical role

[Term]
id: CHEBI:63299
name: carbohydrate derivative
namespace: chebi_ontology
def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." []
subset: 3_STAR
synonym: "carbohydrate derivatives" RELATED [ChEBI]
synonym: "derivatised carbohydrate" RELATED [ChEBI]
synonym: "derivatised carbohydrates" RELATED [ChEBI]
synonym: "derivatized carbohydrate" RELATED [ChEBI]
synonym: "derivatized carbohydrates" RELATED [ChEBI]
is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives
relationship: has_functional_parent CHEBI:16646 ! carbohydrate

[Term]
id: CHEBI:63436
name: carbohydrate acid derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is formally obtained from a carbohydrate acid." []
subset: 3_STAR
synonym: "carbohydrate acid derivatives" RELATED [ChEBI]
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: has_functional_parent CHEBI:33720 ! carbohydrate acid
relationship: is_conjugate_acid_of CHEBI:63551 ! carbohydrate acid derivative anion

[Term]
id: CHEBI:63534
name: monoamine
namespace: chebi_ontology
def: "An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes." []
subset: 3_STAR
synonym: "monoamines" RELATED [ChEBI]
synonym: "naturally occurring monoamine" RELATED [ChEBI]
synonym: "naturally occurring monoamines" RELATED [ChEBI]
xref: PMID:21822758 {source="Europe PMC"}
xref: PMID:21993877 {source="Europe PMC"}
xref: PMID:22005599 {source="Europe PMC"}
xref: PMID:22082101 {source="Europe PMC"}
xref: PMID:22153577 {source="Europe PMC"}
xref: PMID:22213370 {source="Europe PMC"}
xref: PMID:22218931 {source="Europe PMC"}
xref: PMID:22342987 {source="Europe PMC"}
xref: PMID:22371656 {source="Europe PMC"}
is_a: CHEBI:64365 ! aralkylamino compound

[Term]
id: CHEBI:63551
name: carbohydrate acid derivative anion
namespace: chebi_ontology
def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." []
subset: 3_STAR
synonym: "carbohydrate acid anion derivative" RELATED [ChEBI]
synonym: "carbohydrate acid anion derivatives" RELATED [ChEBI]
synonym: "carbohydrate acid derivative anions" RELATED [ChEBI]
is_a: CHEBI:29067 ! carboxylic acid anion
relationship: has_functional_parent CHEBI:33721 ! carbohydrate acid anion
relationship: is_conjugate_base_of CHEBI:63436 ! carbohydrate acid derivative

[Term]
id: CHEBI:64047
name: food additive
namespace: chebi_ontology
def: "Any substance which is added to food to preserve or enhance its flavour and/or appearance." []
subset: 3_STAR
synonym: "food additives" RELATED [ChEBI]
xref: Wikipedia:Food_additive
is_a: CHEBI:33232 ! application
is_a: CHEBI:78295 ! food component

[Term]
id: CHEBI:64049
name: food acidity regulator
namespace: chebi_ontology
def: "A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents." []
subset: 3_STAR
synonym: "acidity regulator" RELATED [ChEBI]
synonym: "acidity regulators" RELATED [ChEBI]
synonym: "food acidity regulators" RELATED [ChEBI]
synonym: "pH control agent" RELATED [ChEBI]
synonym: "pH control agents" RELATED [ChEBI]
xref: Wikipedia:Acidity_regulator
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:64365
name: aralkylamino compound
namespace: chebi_ontology
def: "An organic amino compound in which an aminoalkyl group is linked to an arene." []
subset: 3_STAR
synonym: "aralkylamino compounds" RELATED [ChEBI]
is_a: CHEBI:50047 ! organic amino compound

[Term]
id: CHEBI:64628
name: somatostatin
namespace: chebi_ontology
def: "A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14." []
subset: 3_STAR
synonym: "Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]" RELATED [ChEBI]
synonym: "L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide" EXACT IUPAC_NAME [IUPAC]
synonym: "L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide" RELATED [ChemIDplus]
synonym: "somatostatin" RELATED INN [KEGG_DRUG]
synonym: "Somatostatin-1" RELATED [KEGG_COMPOUND]
synonym: "Somatostatin-14" RELATED [KEGG_COMPOUND]
synonym: "somatostatina" RELATED INN [ChemIDplus]
synonym: "somatostatine" RELATED INN [ChemIDplus]
synonym: "somatostatinum" RELATED INN [ChemIDplus]
synonym: "Synthetic growth hormone release-inhibiting hormone" RELATED [ChemIDplus]
xref: CAS:38916-34-6 {source="KEGG DRUG"}
xref: CAS:38916-34-6 {source="ChemIDplus"}
xref: Drug_Central:2997 {source="DrugCentral"}
xref: HMDB:HMDB0013072
xref: KEGG:C16022
xref: KEGG:D07431
xref: LINCS:LSM-5326
xref: PMID:21922516 {source="Europe PMC"}
xref: PMID:22129035 {source="Europe PMC"}
xref: PMID:22147011 {source="Europe PMC"}
xref: PMID:22251942 {source="Europe PMC"}
xref: PMID:22483686 {source="Europe PMC"}
xref: PMID:22509294 {source="Europe PMC"}
xref: Reaxys:10148626 {source="Reaxys"}
xref: Wikipedia:Somatostatin
is_a: CHEBI:24533 ! heterodetic cyclic peptide
is_a: CHEBI:25905 ! peptide hormone
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C76H104N18O19S2" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "NHXLMOGPVYXJNR-ATOGVRKGSA-N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "1637.87800" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "1636.71666" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H](C)O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N" xsd:string

[Term]
id: CHEBI:64708
name: one-carbon compound
namespace: chebi_ontology
def: "An organic molecular entity containing a single carbon atom (C1)." []
subset: 3_STAR
synonym: "one-carbon compounds" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64709
name: organic acid
namespace: chebi_ontology
def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." []
subset: 3_STAR
synonym: "organic acids" RELATED [ChEBI]
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:64909
name: poison
namespace: chebi_ontology
def: "Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism." []
subset: 3_STAR
synonym: "poisonous agent" RELATED [ChEBI]
synonym: "poisonous agents" RELATED [ChEBI]
synonym: "poisonous substance" RELATED [ChEBI]
synonym: "poisonous substances" RELATED [ChEBI]
synonym: "poisons" RELATED [ChEBI]
synonym: "toxic agent" RELATED [ChEBI]
synonym: "toxic agents" RELATED [ChEBI]
synonym: "toxic substance" RELATED [ChEBI]
synonym: "toxic substances" RELATED [ChEBI]
xref: Wikipedia:Poison
is_a: CHEBI:24432 ! biological role

[Term]
id: CHEBI:65212
name: polysaccharide derivative
namespace: chebi_ontology
def: "A carbohydrate derivative that is any derivative of a polysaccharide." []
subset: 3_STAR
synonym: "polysaccharide derivatives" RELATED [ChEBI]
is_a: CHEBI:167559 ! glycan
is_a: CHEBI:33694 ! biomacromolecule
is_a: CHEBI:63299 ! carbohydrate derivative
relationship: has_functional_parent CHEBI:18154 ! polysaccharide

[Term]
id: CHEBI:65255
name: food preservative
namespace: chebi_ontology
def: "Substances which are added to food in order to prevent decomposition caused by  microbial growth or by undesirable chemical changes." []
subset: 3_STAR
synonym: "food preservatives" RELATED [ChEBI]
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:65256
name: antimicrobial food preservative
namespace: chebi_ontology
def: "A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299)." []
subset: 3_STAR
synonym: "antimicrobial food preservatives" RELATED [ChEBI]
synonym: "antimicrobial preservative" RELATED [ChEBI]
synonym: "antimicrobial preservatives" RELATED [ChEBI]
is_a: CHEBI:33281 ! antimicrobial agent
is_a: CHEBI:65255 ! food preservative

[Term]
id: CHEBI:65296
name: primary ammonium ion
namespace: chebi_ontology
def: "An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3." []
subset: 3_STAR
synonym: "a primary amine" RELATED [UniProt]
synonym: "substituted ammonium" RELATED [ChEBI]
is_a: CHEBI:25697 ! organic cation
is_a: CHEBI:35274 ! ammonium ion derivative
relationship: is_conjugate_acid_of CHEBI:50994 ! primary amino compound
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "H3NR" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "17.031" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "17.02655" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+][*]" xsd:string

[Term]
id: CHEBI:67079
name: anti-inflammatory agent
namespace: chebi_ontology
def: "Any compound that has anti-inflammatory effects." []
subset: 3_STAR
synonym: "anti-inflammatory agents" RELATED [ChEBI]
synonym: "antiinflammatory agent" RELATED [ChEBI]
synonym: "antiinflammatory agents" RELATED [ChEBI]
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:72587
name: (R)-noradrenaline(1+)
namespace: chebi_ontology
def: "An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3." []
subset: 3_STAR
synonym: "(2R)-2-(3,4-dihydroxyphenyl)-2-hydroxyethanaminium" EXACT IUPAC_NAME [IUPAC]
synonym: "(R)-noradrenaline" RELATED [UniProt]
synonym: "(R)-noradrenaline cation" RELATED [ChEBI]
synonym: "(R)-noradrenalinium cation" RELATED [ChEBI]
synonym: "(R)-noradrenalinium(1+)" RELATED [ChEBI]
xref: PDBeChem:E5E
is_a: CHEBI:166902 ! noradrenaline(1+)
relationship: has_role CHEBI:77746 ! human metabolite
relationship: is_conjugate_acid_of CHEBI:18357 ! (R)-noradrenaline
property_value: http://purl.obolibrary.org/obo/chebi/charge "+1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8H12NO3" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchi "InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/p+1/t8-/m0/s1" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/inchikey "SFLSHLFXELFNJZ-QMMMGPOBSA-O" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "170.187" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "170.08117" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C=1(C=CC(=CC1O)[C@H](C[NH3+])O)O" xsd:string

[Term]
id: CHEBI:72695
name: organic molecule
namespace: chebi_ontology
def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." []
subset: 3_STAR
synonym: "organic compound" RELATED [ChEBI]
synonym: "organic compounds" RELATED [ChEBI]
synonym: "organic molecules" RELATED [ChEBI]
is_a: CHEBI:25367 ! molecule
is_a: CHEBI:50860 ! organic molecular entity

[Term]
id: CHEBI:72813
name: exopolysaccharide
namespace: chebi_ontology
def: "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." []
subset: 3_STAR
synonym: "exopolysaccharides" RELATED [ChEBI]
synonym: "extracellular polymeric substance" RELATED [ChEBI]
synonym: "extracellular polymeric substances" RELATED [ChEBI]
xref: MetaCyc:Exopolysaccharides
xref: PMID:11160795 {source="Europe PMC"}
xref: PMID:11785425 {source="Europe PMC"}
xref: PMID:1444258 {source="Europe PMC"}
xref: PMID:15738217 {source="Europe PMC"}
xref: PMID:16075348 {source="Europe PMC"}
xref: PMID:17440912 {source="Europe PMC"}
xref: PMID:18097339 {source="Europe PMC"}
xref: PMID:19453747 {source="Europe PMC"}
xref: PMID:20172021 {source="Europe PMC"}
xref: PMID:20631870 {source="Europe PMC"}
xref: PMID:20718297 {source="Europe PMC"}
xref: PMID:2688547 {source="Europe PMC"}
xref: PMID:6354590 {source="Europe PMC"}
xref: Wikipedia:Exopolysaccharide
xref: Wikipedia:Extracellular_polymeric_substance
is_a: CHEBI:33694 ! biomacromolecule

[Term]
id: CHEBI:73336
name: vulnerary
namespace: chebi_ontology
def: "A drug used in treating and healing of wounds." []
subset: 3_STAR
synonym: "vulneraries" RELATED [ChEBI]
synonym: "wound-healing agent" RELATED [ChEBI]
synonym: "wound-healing agents" RELATED [ChEBI]
synonym: "wound-healing drug" RELATED [ChEBI]
synonym: "wound-healing drugs" RELATED [ChEBI]
xref: Wikipedia:Wound_healing
is_a: CHEBI:23888 ! drug

[Term]
id: CHEBI:73398
name: indole skeleton
namespace: chebi_ontology
def: "A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring." []
subset: 3_STAR
is_a: CHEBI:73541 ! organic heterobicyclic ring
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C8N" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "110.09230" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "110.00307" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "C1(=C(C(=C2C(=C1*)N(C(=C2*)*)*)*)*)*" xsd:string

[Term]
id: CHEBI:73541
name: organic heterobicyclic ring
namespace: chebi_ontology
def: "A bicyclic organic group that contains both carbon and hetero atoms." []
subset: 3_STAR
synonym: "organic heterobicyclic rings" RELATED [ChEBI]
is_a: CHEBI:52845 ! cyclic organic group

[Term]
id: CHEBI:75763
name: eukaryotic metabolite
namespace: chebi_ontology
def: "Any  metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms." []
subset: 3_STAR
synonym: "eukaryotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:75767
name: animal metabolite
namespace: chebi_ontology
alt_id: CHEBI:77721
alt_id: CHEBI:77743
def: "Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals." []
subset: 3_STAR
synonym: "animal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:75768
name: mammalian metabolite
namespace: chebi_ontology
alt_id: CHEBI:77464
alt_id: CHEBI:77744
def: "Any animal metabolite produced during a metabolic reaction in mammals." []
subset: 3_STAR
synonym: "mammalian metabolites" RELATED [ChEBI]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:75771
name: mouse metabolite
namespace: chebi_ontology
def: "Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus)." []
subset: 3_STAR
synonym: "mouse metabolites" RELATED [ChEBI]
synonym: "Mus musculus metabolite" RELATED [ChEBI]
synonym: "Mus musculus metabolites" RELATED [ChEBI]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:75772
name: Saccharomyces cerevisiae metabolite
namespace: chebi_ontology
alt_id: CHEBI:76949
alt_id: CHEBI:76951
def: "Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae)." []
subset: 3_STAR
synonym: "baker's yeast metabolite" RELATED [ChEBI]
synonym: "baker's yeast metabolites" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolite" RELATED [ChEBI]
synonym: "baker's yeast secondary metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae metabolites" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolite" RELATED [ChEBI]
synonym: "S. cerevisiae secondary metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae metabolites" RELATED [ChEBI]
synonym: "Saccharomyces cerevisiae secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:76946 ! fungal metabolite

[Term]
id: CHEBI:75787
name: prokaryotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea." []
subset: 3_STAR
synonym: "prokaryotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76206
name: xenobiotic metabolite
namespace: chebi_ontology
def: "Any metabolite produced by metabolism of a xenobiotic compound." []
subset: 3_STAR
synonym: "xenobiotic metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:76759
name: EC 3.* (hydrolase) inhibitor
namespace: chebi_ontology
def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." []
subset: 3_STAR
synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.* inhibitors" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI]
synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI]
synonym: "hydrolase inhibitor" RELATED [ChEBI]
synonym: "hydrolase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Hydrolase
is_a: CHEBI:23924 ! enzyme inhibitor

[Term]
id: CHEBI:76764
name: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
namespace: chebi_ontology
def: "Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*)." []
subset: 3_STAR
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.* inhibitors" RELATED [ChEBI]
is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor

[Term]
id: CHEBI:76807
name: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*)." []
subset: 3_STAR
synonym: "EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.* inhibitors" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor" RELATED [ChEBI]
synonym: "non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors" RELATED [ChEBI]
is_a: CHEBI:76764 ! EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor

[Term]
id: CHEBI:76924
name: plant metabolite
namespace: chebi_ontology
alt_id: CHEBI:75766
alt_id: CHEBI:76925
def: "Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms." []
subset: 3_STAR
synonym: "plant metabolites" RELATED [ChEBI]
synonym: "plant secondary metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76946
name: fungal metabolite
namespace: chebi_ontology
alt_id: CHEBI:75765
alt_id: CHEBI:76947
def: "Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds." []
subset: 3_STAR
synonym: "fungal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CHEBI:76967
name: human xenobiotic metabolite
namespace: chebi_ontology
def: "Any human metabolite produced by metabolism of a xenobiotic compound in humans." []
subset: 3_STAR
synonym: "human xenobiotic metabolites" RELATED [ChEBI]
is_a: CHEBI:76206 ! xenobiotic metabolite
is_a: CHEBI:77746 ! human metabolite

[Term]
id: CHEBI:76969
name: bacterial metabolite
namespace: chebi_ontology
alt_id: CHEBI:75760
alt_id: CHEBI:76970
def: "Any prokaryotic metabolite produced during a metabolic reaction in bacteria." []
subset: 3_STAR
is_a: CHEBI:75787 ! prokaryotic metabolite

[Term]
id: CHEBI:76971
name: Escherichia coli metabolite
namespace: chebi_ontology
def: "Any bacterial metabolite produced during a metabolic reaction in Escherichia coli." []
subset: 3_STAR
synonym: "E.coli metabolite" RELATED [ChEBI]
synonym: "E.coli metabolites" RELATED [ChEBI]
synonym: "Escherichia coli metabolites" RELATED [ChEBI]
is_a: CHEBI:76969 ! bacterial metabolite

[Term]
id: CHEBI:77746
name: human metabolite
namespace: chebi_ontology
alt_id: CHEBI:75770
alt_id: CHEBI:77123
def: "Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens)." []
subset: 3_STAR
synonym: "H. sapiens metabolite" RELATED [ChEBI]
synonym: "H. sapiens metabolites" RELATED [ChEBI]
synonym: "Homo sapiens metabolite" RELATED [ChEBI]
synonym: "Homo sapiens metabolites" RELATED [ChEBI]
is_a: CHEBI:75768 ! mammalian metabolite

[Term]
id: CHEBI:77941
name: EC 3.5.1.4 (amidase) inhibitor
namespace: chebi_ontology
def: "An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4)." []
subset: 3_STAR
synonym: "acylamidase inhibitor" RELATED [ChEBI]
synonym: "acylamidase inhibitors" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "acylamide amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "amidase (EC 3.5.1.4) inhibitor" RELATED [ChEBI]
synonym: "amidase (EC 3.5.1.4) inhibitors" RELATED [ChEBI]
synonym: "amidase inhibitor" RELATED [ChEBI]
synonym: "amidase inhibitors" RELATED [ChEBI]
synonym: "amidohydrolase inhibitor" RELATED [ChEBI]
synonym: "amidohydrolase inhibitors" RELATED [ChEBI]
synonym: "deaminase inhibitor" RELATED [ChEBI]
synonym: "deaminase inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 (amidase) inhibitors" RELATED [ChEBI]
synonym: "EC 3.5.1.4 inhibitor" RELATED [ChEBI]
synonym: "EC 3.5.1.4 inhibitors" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitor" RELATED [ChEBI]
synonym: "fatty acylamidase inhibitors" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitor" RELATED [ChEBI]
synonym: "N-acetylaminohydrolase inhibitors" RELATED [ChEBI]
xref: Wikipedia:Amidase
is_a: CHEBI:76807 ! EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor

[Term]
id: CHEBI:77974
name: food packaging gas
namespace: chebi_ontology
def: "A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container." []
subset: 3_STAR
synonym: "food packaging gases" RELATED [ChEBI]
xref: Wikipedia:Packaging_gas
is_a: CHEBI:64047 ! food additive

[Term]
id: CHEBI:78295
name: food component
namespace: chebi_ontology
def: "A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants." []
subset: 3_STAR
synonym: "dietary component" RELATED [ChEBI]
synonym: "dietary components" RELATED [ChEBI]
synonym: "food components" RELATED [ChEBI]
is_a: CHEBI:52211 ! physiological role

[Term]
id: CHEBI:78433
name: refrigerant
namespace: chebi_ontology
def: "A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a \"R\" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure." []
subset: 3_STAR
synonym: "refrigerants" RELATED [ChEBI]
xref: Wikipedia:Refrigerant
is_a: CHEBI:33232 ! application

[Term]
id: CHEBI:78608
name: alpha-amino acid zwitterion
namespace: chebi_ontology
alt_id: CHEBI:83409
def: "An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3." []
subset: 3_STAR
synonym: "an alpha-amino acid" RELATED [UniProt]
xref: MetaCyc:Alpha-Amino-Acids {source="SUBMITTER"}
is_a: CHEBI:35238 ! amino acid zwitterion
relationship: is_tautomer_of CHEBI:33704 ! alpha-amino acid
property_value: http://purl.obolibrary.org/obo/chebi/charge "0" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/formula "C2H4NO2R" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/mass "74.059" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/monoisotopicmass "74.02420" xsd:string
property_value: http://purl.obolibrary.org/obo/chebi/smiles "[NH3+]C([*])C([O-])=O" xsd:string

[Term]
id: CHEBI:78616
name: carbohydrates and carbohydrate derivatives
namespace: chebi_ontology
def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." []
subset: 3_STAR
synonym: "carbohydrates and derivatives" RELATED [ChEBI]
synonym: "carbohydrates and their derivatives" RELATED [ChEBI]
is_a: CHEBI:36963 ! organooxygen compound

[Term]
id: CHEBI:78675
name: fundamental metabolite
namespace: chebi_ontology
def: "Any metabolite produced by all living cells." []
subset: 3_STAR
synonym: "essential metabolite" RELATED [ChEBI]
synonym: "essential metabolites" RELATED [ChEBI]
synonym: "fundamental metabolites" RELATED [ChEBI]
is_a: CHEBI:25212 ! metabolite

[Term]
id: CHEBI:79387
name: trivalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of three." []
subset: 3_STAR
synonym: "trivalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79388
name: divalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of two." []
subset: 3_STAR
synonym: "divalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:79389
name: monovalent inorganic anion
namespace: chebi_ontology
def: "Any inorganic anion with a valency of one." []
subset: 3_STAR
synonym: "monovalent inorganic anions" RELATED [ChEBI]
is_a: CHEBI:24834 ! inorganic anion

[Term]
id: CHEBI:83039
name: crustacean metabolite
namespace: chebi_ontology
def: "An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill." []
subset: 3_STAR
synonym: "crustacean metabolites" RELATED [ChEBI]
is_a: CHEBI:75767 ! animal metabolite

[Term]
id: CHEBI:83056
name: Daphnia magna metabolite
namespace: chebi_ontology
def: "A Daphnia metabolite produced by the species Daphnia magna." []
subset: 3_STAR
synonym: "Daphnia magna metabolites" RELATED [ChEBI]
is_a: CHEBI:83057 ! Daphnia metabolite

[Term]
id: CHEBI:83057
name: Daphnia metabolite
namespace: chebi_ontology
def: "A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia" []
subset: 3_STAR
synonym: "Daphnia metabolites" RELATED [ChEBI]
xref: Wikipedia:Daphnia
is_a: CHEBI:83039 ! crustacean metabolite

[Term]
id: CHEBI:84729
name: hydroxyindoles
namespace: chebi_ontology
def: "Any member of the class of  indoles carrying at least one hydroxy group." []
subset: 3_STAR
is_a: CHEBI:24828 ! indoles
is_a: CHEBI:33822 ! organic hydroxy compound

[Term]
id: CHEBI:84735
name: algal metabolite
namespace: chebi_ontology
def: "Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae." []
subset: 3_STAR
synonym: "algal metabolites" RELATED [ChEBI]
is_a: CHEBI:75763 ! eukaryotic metabolite

[Term]
id: CL:0000000
name: cell
namespace: cell
def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah]
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).
subset: cellxgene_subset
subset: ubprop:upper_level
xref: CALOHA:TS-2035
xref: FBbt:00007002 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:68646
xref: GO:0005623
xref: KUPO:0000002
xref: MESH:D002477
xref: VHOG:0001533
xref: WBbt:0004017
xref: XAO:0003012
xref: ZFA:0009000 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: UBERON:0000061 ! anatomical structure
disjoint_from: GO:0031012 ! extracellular matrix
disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle
relationship: has_part GO:0005634 {gci_filler="PATO:0001407", gci_relation="has_characteristic"} ! nucleus
relationship: has_part GO:0005634 {gci_filler="PATO:0001908", gci_relation="has_characteristic"} ! nucleus
relationship: in_taxon NCBITaxon:131567 ! cellular organisms
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms
property_value: editor_note "CL and GO definitions of cell differ based on inclusive or exclusive of cell wall, etc." xsd:string
property_value: editor_note "We struggled with this definition. We are worried about circularity. We also considered requiring the capability of metabolism." xsd:string

[Term]
id: CL:0000005
name: fibroblast neural crest derived
def: "Any fibroblast that is deriived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
is_a: CL:0000057 ! fibroblast
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000006
name: neuronal receptor cell
subset: cellxgene_subset
synonym: "neuronal receptor cell (sensu Animalia)" EXACT []
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000007
name: early embryonic cell (metazoa)
def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm]
is_a: CL:0002321 ! embryonic cell (metazoa)

[Term]
id: CL:0000008
name: migratory cranial neural crest cell
def: "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007091]
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000011
name: migratory trunk neural crest cell
def: "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination." [https://orcid.org/0000-0001-5208-3432, ZFA:0007095]
is_a: CL:0000333 ! migratory neural crest cell

[Term]
id: CL:0000014
name: germ line stem cell
def: "A stem cell that is the precursor of gametes." [doi:10.1016/j.stem.2012.05.016]
synonym: "germline stem cell" EXACT []
xref: FBbt:00004861
is_a: CL:0000034 {is_inferred="true"} ! stem cell
is_a: CL:0000039 ! germ line cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000015
name: male germ cell
def: "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis." [https://orcid.org/0000-0001-5208-3432, PMID:29462262]
subset: cellxgene_subset
xref: FMA:72290
xref: MA:0002765
xref: ncithesaurus:Spermatogenic_Cell
xref: VHOG:0001531
is_a: CL:0000586 {is_inferred="true"} ! germ cell
relationship: capable_of_part_of GO:0007283 ! spermatogenesis
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/574" xsd:string

[Term]
id: CL:0000017
name: spermatocyte
def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:D013090]
xref: BTO:0001275
xref: CALOHA:TS-0951
xref: EMAPA:31484
xref: FBbt:00004936
xref: FMA:84049
xref: WBbt:0006799
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0048137 ! spermatocyte division
relationship: capable_of GO:0048137 ! spermatocyte division
relationship: develops_from CL:0000020 ! spermatogonium

[Term]
id: CL:0000018
name: spermatid
def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:D013087]
synonym: "nematoblast" EXACT []
xref: BTO:0001274
xref: CALOHA:TS-0950
xref: EMAPA:31486
xref: FBbt:00004942
xref: FMA:72294
xref: WBbt:0006800
is_a: CL:0000015 ! male germ cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0001675 ! acrosome assembly
intersection_of: capable_of GO:0007288 ! sperm axoneme assembly
intersection_of: capable_of GO:0007289 ! spermatid nucleus differentiation
intersection_of: has_characteristic PATO:0001375 ! haploid
relationship: capable_of GO:0001675 ! acrosome assembly
relationship: capable_of GO:0007288 ! sperm axoneme assembly
relationship: capable_of GO:0007289 ! spermatid nucleus differentiation
relationship: develops_from CL:0000657 ! secondary spermatocyte

[Term]
id: CL:0000019
name: sperm
def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:D013094]
subset: cellxgene_subset
synonym: "sperm cell" EXACT []
synonym: "spermatozoid" EXACT []
synonym: "spermatozoon" EXACT []
xref: BTO:0001277
xref: BTO:0002046
xref: CALOHA:TS-0949
xref: FBbt:00004954
xref: FMA:67338
xref: WBbt:0006798
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000408 {is_inferred="true"} ! male gamete
relationship: develops_from CL:0000018 ! spermatid

[Term]
id: CL:0000020
name: spermatogonium
def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:D013093]
synonym: "spermatogonial cell" EXACT []
xref: BTO:0000958
xref: CALOHA:TS-2193
xref: EMAPA:31482
xref: FBbt:00004934
xref: FBbt:00004935
xref: FMA:72291
is_a: CL:0000015 ! male germ cell
intersection_of: CL:0000015 ! male germ cell
intersection_of: has_characteristic PATO:0001394 ! diploid
intersection_of: has_characteristic PATO:0001501 ! immature
relationship: has_characteristic PATO:0001394 ! diploid
relationship: has_characteristic PATO:0001501 ! immature

[Term]
id: CL:0000021
name: female germ cell
def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446]
subset: cellxgene_subset
xref: MA:0000388
xref: ncithesaurus:Egg
xref: VHOG:0001530
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0048477 ! oogenesis
relationship: capable_of GO:0048477 ! oogenesis

[Term]
id: CL:0000022
name: female germ line stem cell
def: "A stem cell that is the precursor of female gametes." [doi:10.1016/j.stem.2012.05.016]
xref: FBbt:00004873
is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0017145 ! stem cell division

[Term]
id: CL:0000023
name: oocyte
def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
synonym: "oogonium" RELATED []
xref: BTO:0000964
xref: CALOHA:TS-0711
xref: FBbt:00004886
xref: FMA:18644
xref: MESH:D009865
xref: WBbt:0006797
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: participates_in GO:0007143 ! female meiotic nuclear division

[Term]
id: CL:0000024
name: oogonial cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
xref: FMA:83673
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
intersection_of: CL:0000021 ! female germ cell
intersection_of: capable_of GO:0000278 ! mitotic cell cycle
relationship: capable_of GO:0000278 ! mitotic cell cycle
relationship: develops_from CL:0000670 ! primordial germ cell

[Term]
id: CL:0000025
name: egg cell
def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544]
synonym: "mature oocyte" EXACT []
synonym: "ovum" EXACT []
xref: BTO:0000369
xref: BTO:0003801
xref: CALOHA:TS-2191
xref: FBbt:00057012
xref: FMA:67343
xref: MESH:D010063
is_a: CL:0000675 {is_inferred="true"} ! female gamete
relationship: develops_from CL:0000023 ! oocyte
relationship: participates_in GO:0007143 ! female meiotic nuclear division
property_value: depiction "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI

[Term]
id: CL:0000027
name: smooth muscle cell neural crest derived
def: "A smooth muscle cell derived from the neural crest." [https://orcid.org/0000-0001-5208-3432]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell

[Term]
id: CL:0000029
name: neural crest derived neuron
synonym: "neuron neural crest derived" EXACT []
is_a: CL:0000540 {is_inferred="true"} ! neuron
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0002676 ! neural crest derived neuroblast

[Term]
id: CL:0000031
name: neuroblast (sensu Vertebrata)
def: "A cell that will develop into a neuron often after a migration phase." [GOC:NV, http://en.wikipedia.org/wiki/Neuroblast]
subset: cellxgene_subset
synonym: "neuroblast" EXACT []
xref: BTO:0000930
xref: FMA:70563
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000255 ! eukaryotic cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: CL:0000034
name: stem cell
def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:D013234]
comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "animal stem cell" EXACT []
xref: CALOHA:TS-2086
xref: FMA:63368
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
relationship: capable_of GO:0017145 ! stem cell division
relationship: in_taxon NCBITaxon:33208 ! Metazoa
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000035
name: single fate stem cell
def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm]
synonym: "unipotent stem cell" EXACT []
synonym: "unipotential stem cell" EXACT []
xref: FMA:70569
is_a: CL:0000723 ! somatic stem cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
intersection_of: has_characteristic PATO:0001400 ! unipotent
relationship: has_characteristic PATO:0001400 ! unipotent

[Term]
id: CL:0000037
name: hematopoietic stem cell
def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770]
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "blood forming stem cell" EXACT []
synonym: "colony forming unit hematopoietic" RELATED []
synonym: "hemopoietic stem cell" EXACT []
synonym: "HSC" RELATED OMO:0003000 []
xref: BTO:0000725
xref: CALOHA:TS-0448
xref: FMA:86475
xref: MESH:D006412
xref: VHOG:0001485
is_a: CL:0000723 ! somatic stem cell
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: capable_of GO:0048103 ! somatic stem cell division
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: capable_of GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000038
name: erythroid progenitor cell
def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000764 ! erythroid lineage cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell

[Term]
id: CL:0000039
name: germ line cell
def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544]
comment: Originally this term had some plant germ line cell children.
subset: general_cell_types_upper_slim
subset: ubprop:upper_level
is_a: CL:0000000 ! cell
relationship: capable_of GO:0022414 ! reproductive process

[Term]
id: CL:0000048
name: multi fate stem cell
def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add]
synonym: "multi-fate stem cell" EXACT []
synonym: "multifate stem cell" EXACT []
synonym: "multipotent cell" EXACT []
synonym: "multipotent stem cell" EXACT []
xref: FMA:84789
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0017145 ! stem cell division
intersection_of: has_characteristic PATO:0001402 ! multipotent
relationship: has_characteristic PATO:0001402 ! multipotent

[Term]
id: CL:0000049
name: common myeloid progenitor
def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461]
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor.  For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-GEMM" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CFU-S" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "CMP" RELATED OMO:0003000 [ISBN:0878932437]
synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437]
synonym: "common myeloid precursor" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
xref: BTO:0004730
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell
disjoint_from: CL:0000051 ! common lymphoid progenitor
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000050
name: megakaryocyte-erythroid progenitor cell
def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566]
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-EM" EXACT []
synonym: "CFU-MegE" EXACT []
synonym: "colony forming unit erythroid megakaryocyte" EXACT []
synonym: "Meg/E progenitor" EXACT []
synonym: "megakaryocyte/erythrocyte progenitor" EXACT []
synonym: "megakaryocyte/erythroid progenitor cell" EXACT []
synonym: "MEP" EXACT []
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000051
name: common lymphoid progenitor
def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251]
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CLP" RELATED OMO:0003000 []
synonym: "committed lymphopoietic stem cell" RELATED []
synonym: "common lymphocyte precursor" EXACT []
synonym: "common lymphocyte progenitor" EXACT []
synonym: "common lymphoid precursor" EXACT []
synonym: "early lymphocyte progenitor" RELATED []
synonym: "ELP" RELATED OMO:0003000 []
synonym: "lymphoid stem cell" RELATED []
synonym: "lymphopoietic stem cell" RELATED []
is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
relationship: capable_of GO:0030098 ! lymphocyte differentiation
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000052
name: totipotent stem cell
def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm]
synonym: "totipotential stem cell" EXACT []
xref: FMA:84790
xref: MESH:D039901
is_a: CL:0000723 ! somatic stem cell

[Term]
id: CL:0000055
name: non-terminally differentiated cell
def: "A precursor cell with a limited number of potential fates." [SANBI:mhl]
comment: define using PATO mulit-potent or oligopotent?
subset: cellxgene_subset
synonym: "blast cell" EXACT []
xref: BTO:0000125
xref: FMA:84782
is_a: CL:0011115 ! precursor cell

[Term]
id: CL:0000056
name: myoblast
def: "A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair." [GOC:tfm, MESH:D032446, PMID:21849021]
xref: BTO:0000222
xref: CALOHA:TS-0650
xref: FBbt:00005083
xref: FMA:70335
xref: VHOG:0001529
is_a: CL:0000680 ! muscle precursor cell

[Term]
id: CL:0000057
name: fibroblast
def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:D005347]
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
xref: BTO:0000452
xref: CALOHA:TS-0362
xref: FMA:63877
xref: NCIT:C12482
xref: VHOG:0001482
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000058
name: chondroblast
def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256]
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007009 ! prechondroblast
relationship: produces UBERON:0002418 ! cartilage tissue

[Term]
id: CL:0000064
name: ciliated cell
def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm]
subset: cellxgene_subset
xref: VHOG:0001532
xref: XAO:0000031
is_a: CL:0000255 ! eukaryotic cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000000 ! cell
intersection_of: has_part GO:0005929 ! cilium
relationship: has_part GO:0005929 ! cilium

[Term]
id: CL:0000066
name: epithelial cell
def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:D004847]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "epitheliocyte" EXACT []
xref: BTO:0000414
xref: CALOHA:TS-2026
xref: CARO:0000077
xref: FBbt:00000124 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:66768
xref: WBbt:0003672
xref: ZFA:0009034 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
disjoint_from: CL:0000738 ! leukocyte
relationship: part_of UBERON:0000483 ! epithelium
property_value: depiction "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000067
name: ciliated epithelial cell
def: "An epithelial cell that has a cilia." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70605
is_a: CL:0000064 ! ciliated cell
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: has_part GO:0005929 ! cilium

[Term]
id: CL:0000068
name: duct epithelial cell
def: "An epithelial cell that is part of a duct." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000058 ! duct
relationship: part_of UBERON:0000058 ! duct

[Term]
id: CL:0000069
name: branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell

[Term]
id: CL:0000071
name: blood vessel endothelial cell
def: "An endothelial cell that lines the vasculature." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cuboidal endothelial cell of vascular tree" EXACT []
is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell
is_a: CL:0002139 ! endothelial cell of vascular tree
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0004638 ! blood vessel endothelium
relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell
relationship: part_of UBERON:0004638 ! blood vessel endothelium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000072
name: non-branched duct epithelial cell
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002078 ! meso-epithelial cell

[Term]
id: CL:0000075
name: columnar/cuboidal epithelial cell
def: "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GO:0002065, https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000066 ! epithelial cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000076
name: squamous epithelial cell
subset: cellxgene_subset
xref: CALOHA:TS-1249
is_a: CL:0000066 ! epithelial cell

[Term]
id: CL:0000077
name: mesothelial cell
def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "mesotheliocyte" EXACT []
xref: FMA:66773
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000080
name: circulating cell
def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0000179 ! haemolymphatic fluid

[Term]
id: CL:0000081
name: blood cell
def: "A cell found predominately in the blood." [GOC:add, GOC:tfm]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
xref: FMA:62844
xref: MESH:D001773
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0008015 ! blood circulation
relationship: capable_of GO:0008015 ! blood circulation

[Term]
id: CL:0000082
name: epithelial cell of lung
def: "An epithelial cell of the lung." [https://orcid.org/0000-0001-5208-3432]
subset: cellxgene_subset
synonym: "lung epithelial cell" EXACT []
xref: BTO:0004299
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000115 ! lung epithelium

[Term]
id: CL:0000083
name: epithelial cell of pancreas
def: "An epithelial cell of the pancreas." [GOC:tfm]
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0000223 ! endodermal cell
relationship: part_of UBERON:0001264 ! pancreas

[Term]
id: CL:0000084
name: T cell
def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "immature T cell" RELATED []
synonym: "mature T cell" RELATED []
synonym: "T lymphocyte" EXACT []
synonym: "T-cell" EXACT []
synonym: "T-lymphocyte" EXACT []
xref: BTO:0000782
xref: CALOHA:TS-1001
xref: FMA:62870
xref: MESH:D013601
xref: VHOG:0001479
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: capable_of GO:0002456 ! T cell mediated immunity
relationship: capable_of GO:0002456 ! T cell mediated immunity
relationship: develops_from CL:0000827 ! pro-T cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000095
name: neuron associated cell
subset: cellxgene_subset
is_a: CL:0002319 ! neural cell
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000098
name: sensory epithelial cell
def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000099
name: interneuron
def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:D007395]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0003811
xref: FBbt:00005125
xref: FMA:67313
xref: WBbt:0005113
is_a: CL:0000540 ! neuron
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000100
name: motor neuron
def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement." [MESH:D009046, PMID:16875686]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "motoneuron" EXACT []
xref: BTO:0000312
xref: FBbt:00005123
xref: FMA:83617
xref: WBbt:0005409
is_a: CL:0000527 ! efferent neuron
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000101
name: sensory neuron
def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544]
xref: BTO:0001037
xref: FBbt:00005124
xref: FMA:84649
xref: MESH:D011984
xref: WBbt:0005759
is_a: CL:0000526 ! afferent neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception

[Term]
id: CL:0000107
name: autonomic neuron
def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm]
xref: FMA:80121
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: has_soma_location UBERON:0002410 ! autonomic nervous system
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_soma_location UBERON:0002410 ! autonomic nervous system

[Term]
id: CL:0000108
name: cholinergic neuron
def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm]
xref: BTO:0004902
xref: FBbt:00007173
xref: FMA:84796
xref: MESH:D059329
xref: WBbt:0006840
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: capable_of GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: CL:0000113
name: mononuclear phagocyte
def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0001433
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
is_a: CL:0000842 ! mononuclear cell
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: has_characteristic PATO:0001407 ! mononucleate
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000115
name: endothelial cell
def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341]
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endotheliocyte" EXACT []
xref: BTO:0001176
xref: CALOHA:TS-0278
xref: FMA:66772
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 ! meso-epithelial cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
is_a: CL:0000540 ! neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0001017 ! central nervous system

[Term]
id: CL:0000125
name: glial cell
def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:D009457]
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571
subset: cellxgene_subset
subset: general_cell_types_upper_slim
synonym: "neuroglia" RELATED []
synonym: "neuroglial cell" EXACT []
xref: BTO:0002606
xref: CALOHA:TS-0415
xref: FBbt:00005144
xref: FMA:54536
is_a: CL:0000095 ! neuron associated cell

[Term]
id: CL:0000133
name: neurectodermal cell
def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X]
synonym: "neurectoderm cell" EXACT []
is_a: CL:0000221 ! ectodermal cell

[Term]
id: CL:0000134
name: mesenchymal stem cell
def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544]
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
subset: cellxgene_subset
synonym: "BMSC" RELATED OMO:0003000 []
synonym: "bone marrow stromal cells" NARROW []
synonym: "CFU-F" RELATED OMO:0003000 []
synonym: "colony-forming unit-fibroblast" NARROW []
synonym: "marrow stromal cells" NARROW [PMID:11378515]
synonym: "mesenchymal precursor cell" RELATED []
synonym: "mesenchymal progenitor cells" RELATED OMO:0003004 [MESH:D044982]
synonym: "mesenchymal stem cell" RELATED []
synonym: "mesenchymal stromal cell" RELATED []
synonym: "mesenchymal stromal cells" RELATED OMO:0003004 []
synonym: "MSC" RELATED OMO:0003000 [PMID:11378515]
synonym: "stem cells, mesenchymal" RELATED OMO:0003004 [MESH:D044982]
xref: BTO:0002625
xref: BTO:0003298
xref: FMA:70546
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/474" xsd:string

[Term]
id: CL:0000136
name: adipocyte
def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:D017667]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "adipose cell" EXACT []
synonym: "fat cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000138
name: chondrocyte
def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:D019902]
subset: cellxgene_subset
synonym: "cartilage cell" EXACT []
xref: BTO:0000249
xref: CALOHA:TS-0138
xref: FMA:66782
is_a: CL:0000153 ! glycosaminoglycan secreting cell
is_a: CL:0000667 ! collagen secreting cell
relationship: develops_from CL:0000058 ! chondroblast
relationship: located_in UBERON:0002418 ! cartilage tissue

[Term]
id: CL:0000145
name: professional antigen presenting cell
def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149]
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "APC" RELATED OMO:0003000 []
is_a: CL:0000738 ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: CL:0000147
name: pigment cell
def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm]
synonym: "chromatocyte" EXACT []
synonym: "chromatophore" EXACT []
xref: VHOG:0001678
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000149
name: visual pigment cell
synonym: "pigment cell" BROAD []
is_a: CL:0000147 ! pigment cell

[Term]
id: CL:0000150
name: glandular epithelial cell
name: glandular secretory epithelial cell
def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm]
def: "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous." [GOC:tfm, ORCID:0000-0002-7073-9172]
subset: cellxgene_subset
synonym: "glandular epithelial cell" EXACT []
xref: CALOHA:TS-2085
xref: FMA:86494
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002530 ! gland
relationship: part_of UBERON:0002530 ! gland
relationship: part_of UBERON:0006799 ! glandular epithelium

[Term]
id: CL:0000151
name: secretory cell
def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
xref: BTO:0003659
xref: FMA:86916
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0032940 ! secretion by cell
relationship: capable_of GO:0032940 ! secretion by cell

[Term]
id: CL:0000152
name: exocrine cell
def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684]
subset: general_cell_types_upper_slim
xref: FMA:16014
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002365 ! exocrine gland
relationship: part_of UBERON:0002365 ! exocrine gland

[Term]
id: CL:0000153
name: glycosaminoglycan secreting cell
def: "A cell that secretes glycosaminoglycans." [GOC:tfm]
synonym: "GAG secreting cell" EXACT []
synonym: "hyaluronic acid secreting cell" NARROW []
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: CL:0000447 ! carbohydrate secreting cell

[Term]
id: CL:0000154
name: protein secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0009306 ! protein secretion
relationship: capable_of GO:0009306 ! protein secretion

[Term]
id: CL:0000159
name: seromucus secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000163
name: endocrine cell
def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:D055098]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "endocrinocyte" EXACT []
xref: FMA:83809
is_a: CL:0000151 ! secretory cell
is_a: CL:0000164 {gci_relation="part_of", gci_filler="UBERON:0000945"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0000160", gci_relation="part_of"} ! enteroendocrine cell
is_a: CL:0000164 {gci_filler="UBERON:0001264", gci_relation="part_of"} ! enteroendocrine cell
is_a: CL:0000255 ! eukaryotic cell
relationship: part_of UBERON:0000949 ! endocrine system
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000164
name: enteroendocrine cell
def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl]
subset: cellxgene_subset
xref: BTO:0003865
xref: FMA:62930
xref: MESH:D019858
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000163 ! endocrine cell

[Term]
id: CL:0000165
name: neuroendocrine cell
def: "A neuron that is capable of some hormone secretion in response to neuronal signals." [MESH:D055099]
comment: The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron. {xref="https://www.clinicalkey.com/#!/content/book/3-s2.0-B9780323555968000073", xref="PMID:5342440"}
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "neurosecretory cell" RELATED []
synonym: "neurosecretory neuron" RELATED []
xref: BTO:0002691
xref: FBbt:00005130
xref: FMA:83810
is_a: CL:0000163 ! endocrine cell
is_a: CL:0000527 ! efferent neuron
is_a: CL:0000710 ! neurecto-epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0046879 ! hormone secretion
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000167
name: peptide hormone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030072 ! peptide hormone secretion
relationship: capable_of GO:0030072 ! peptide hormone secretion

[Term]
id: CL:0000168
name: insulin secreting cell
xref: BTO:0000783
is_a: CL:0000154 ! protein secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0030073 ! insulin secretion
relationship: capable_of GO:0030073 ! insulin secretion

[Term]
id: CL:0000169
name: type B pancreatic cell
def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651]
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "B-cell of pancreatic islet" EXACT [FMA:70586]
synonym: "beta cell" BROAD [ZFA:0009102]
synonym: "beta cell islet" RELATED [MA:0002419]
synonym: "beta cell of pancreatic islet" EXACT [FMA:70586]
synonym: "insulin-secreting cell" EXACT [FMA:70586]
synonym: "pancreatic B cell" EXACT []
synonym: "pancreatic B-cell" EXACT [FMA:70586]
synonym: "pancreatic beta cell" EXACT [FMA:70586]
synonym: "pancreatic islet core" EXACT [MA:0002419]
synonym: "type B enteroendocrine cell" EXACT [FMA:70586]
xref: BTO:0000783
xref: EV:0200009
xref: FMA:70586
xref: MA:0002419
xref: ncithesaurus:Beta_Cell
is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0030073 ! insulin secretion
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000170
name: glucagon secreting cell
def: "A cell that secretes glucagon." [GOC:tfm]
synonym: "glucagon-secreting cell" EXACT []
xref: FMA:84045
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
relationship: capable_of GO:0070091 ! glucagon secretion

[Term]
id: CL:0000171
name: pancreatic A cell
def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "alpha cell of islet of Langerhans" EXACT []
synonym: "pancreatic alpha cell" EXACT []
xref: BTO:0000990
xref: FMA:70585
xref: MESH:D050416
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000172
name: somatostatin secreting cell
is_a: CL:0000167 ! peptide hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070253 ! somatostatin secretion
relationship: capable_of GO:0070253 ! somatostatin secretion

[Term]
id: CL:0000173
name: pancreatic D cell
def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "D-cell of pancreatic islet" EXACT []
synonym: "delta cell of islet" EXACT []
synonym: "delta cell of pancreatic islet" EXACT []
synonym: "pancreatic D-cell" EXACT []
synonym: "pancreatic delta cell" EXACT []
synonym: "somatostatin-secreting pancreatic cell" EXACT []
xref: BTO:0000803
xref: FMA:70587
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000174
name: steroid hormone secreting cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035929 ! steroid hormone secretion
relationship: capable_of GO:0035929 ! steroid hormone secretion

[Term]
id: CL:0000182
name: hepatocyte
def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:D022781, PMID:19717280]
comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive.
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000417 ! endopolyploid cell
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: capable_of GO:0006699 ! bile acid biosynthetic process
relationship: capable_of GO:0098754 ! detoxification
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002107 ! liver
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000183
name: contractile cell
def: "A cell whose primary function is to shorten." [FB:ma]
subset: cellxgene_subset
is_a: CL:0000000 ! cell

[Term]
id: CL:0000187
name: muscle cell
def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:D032342]
subset: cellxgene_subset
synonym: "muscle fiber" EXACT []
synonym: "myocyte" EXACT []
xref: BTO:0000888
xref: BTO:0000902
xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
is_a: CL:0000183 ! contractile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000393 ! electrically responsive cell
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from CL:0000056 ! myoblast
property_value: depiction "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI

[Term]
id: CL:0000188
name: cell of skeletal muscle
def: "A somatic cell located in skeletal muscle." [GOC:tfm]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "skeletal muscle cell" EXACT []
xref: BTO:0004392
xref: CALOHA:TS-2158
xref: FMA:9727
xref: https://cellxgene.cziscience.com/cellguide/CL_0000188
xref: ZFA:0009115 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of UBERON:0001134 ! skeletal muscle tissue
property_value: RO:0002175 NCBITaxon:9606
property_value: term:description "Skeletal muscle cells, or myocytes, are essential for the musculoskeletal system, featuring a striated appearance from tightly packed sarcomeres. These elongated, multi-nucleated cells convert ATP into mechanical energ and are key for voluntary movement and posture. They also are responsible for maintaining body temperature, storing nutrients, and stabilizing joints.\nSkeletal muscle cells organize themselves tightly into bundles to form muscle fibers. Embedded within each of these cells are thousands of myofibrils, which are made up of the contractile proteins, actin (the thin filament), and myosin (the thick filament). Contraction of a skeletal muscle cell occurs when these myofibrils shorten, a process driven by the sliding of actin and myosin filaments over each other in a mechanism famously known as the sliding filament theory.\nAdditionally, skeletal muscle cells exhibit a high degree of plasticity, which allows for their adaptation in response to alterations in functional demands or damages. They have an innate regenerative capacity due to the presence of satellite cells—quiescent muscle stem cells that reside within the muscle fibers. Upon muscle injury, these satellite cells become activated, proliferate, and differentiate into new muscle cells, thereby contributing to the repair and growth of injured skeletal muscle. With this, skeletal muscle cells serve not only a pivotal biomechanical function but also possess a great capacity for self-healing and regeneration.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/cphy.c160033", xref="DOI:10.3390/biology10101056", xref="https://www.nature.com/scitable/topicpage/the-sliding-filament-theory-of-muscle-contraction-14567666/", xref="https://www.ncbi.nlm.nih.gov/books/NBK537139", xref="https://www.ncbi.nlm.nih.gov/books/NBK9961/"}

[Term]
id: CL:0000192
name: smooth muscle cell
def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:D032389, PMID:9315361]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "myocytes, smooth muscle" EXACT [MESH:D032389]
synonym: "non-striated muscle cell" BROAD []
synonym: "SMCs" EXACT [PMID:9315361]
synonym: "smooth muscle fiber" EXACT []
xref: BTO:0004576
xref: CALOHA:TS-2159
xref: FMA:14072
is_a: CL:0008000 ! non-striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
relationship: develops_from CL:0000514 ! smooth muscle myoblast
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000197
name: sensory receptor cell
def: "A cell that is capable of detection of a stimulus involved in sensory perception." []
synonym: "receptor cell" EXACT []
xref: MESH:D011984
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: part_of UBERON:0001032 ! sensory system
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system

[Term]
id: CL:0000206
name: chemoreceptor cell
def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:D002628]
is_a: CL:0000197 ! sensory receptor cell
intersection_of: CL:0000197 ! sensory receptor cell
intersection_of: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: capable_of GO:0050907 ! detection of chemical stimulus involved in sensory perception

[Term]
id: CL:0000210
name: photoreceptor cell
def: "A cell specialized to detect and transduce light." [MESH:D010786]
subset: cellxgene_subset
xref: BTO:0001060
xref: CALOHA:TS-0868
xref: FMA:86740
is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception
property_value: depiction "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI

[Term]
id: CL:0000211
name: electrically active cell
def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma]
is_a: CL:0000000 ! cell

[Term]
id: CL:0000213
name: lining cell
def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb]
synonym: "boundary cell" EXACT []
is_a: CL:0000215 ! barrier cell

[Term]
id: CL:0000214
name: synovial cell
def: "A cell located in the synovial joint." []
synonym: "synoviocyte" EXACT []
xref: CALOHA:TS-0995
is_a: CL:0000213 ! lining cell
is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell
relationship: part_of UBERON:0002217 ! synovial joint

[Term]
id: CL:0000215
name: barrier cell
def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb]
is_a: CL:0000000 ! cell

[Term]
id: CL:0000216
name: Sertoli cell
def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:D012708]
subset: cellxgene_subset
xref: BTO:0001238
xref: CALOHA:TS-0922
xref: FMA:72298
xref: VHOG:0001348
is_a: CL:0000511 ! androgen binding protein secreting cell
is_a: CL:0000630 {is_inferred="true"} ! supporting cell
is_a: CL:0002625 ! seminiferous tubule epithelial cell
is_a: CL:1100001 ! secretory epithelial cell
intersection_of: CL:0000630 ! supporting cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis

[Term]
id: CL:0000219
name: motile cell
def: "A cell that moves by its own activities." [FB:ma]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0048870 ! cell motility
relationship: capable_of GO:0048870 ! cell motility

[Term]
id: CL:0000221
name: ectodermal cell
def: "A cell of the outer of the three germ layers of the embryo." [MESH:D004475]
subset: cellxgene_subset
synonym: "ectoderm cell" EXACT []
xref: FMA:72549
xref: ZFA:0009137 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000924 ! ectoderm

[Term]
id: CL:0000222
name: mesodermal cell
def: "A cell of the middle germ layer of the embryo." [MESH:D008648]
subset: cellxgene_subset
synonym: "mesoblast" EXACT []
synonym: "mesoderm cell" EXACT []
xref: FMA:72554
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000926 ! mesoderm

[Term]
id: CL:0000223
name: endodermal cell
def: "A cell of the inner of the three germ layers of the embryo." [MESH:D004707]
synonym: "endoderm cell" EXACT []
xref: FMA:72555
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: part_of UBERON:0000925 ! endoderm

[Term]
id: CL:0000225
name: anucleate cell
def: "A cell that lacks a nucleus." [FB:ma]
synonym: "non-nucleated cell" EXACT []
xref: FMA:68647
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001405 ! anucleate
disjoint_from: CL:0002242 ! nucleate cell
relationship: has_characteristic PATO:0001405 ! anucleate

[Term]
id: CL:0000226
name: single nucleate cell
def: "A cell with a single nucleus." [FB:ma, GOC:tfm]
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001407 ! mononucleate
relationship: has_characteristic PATO:0001407 ! mononucleate

[Term]
id: CL:0000227
name: binucleate cell
is_a: CL:0000228 ! multinucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001406 ! binucleate
relationship: has_characteristic PATO:0001406 ! binucleate

[Term]
id: CL:0000228
name: multinucleate cell
def: "A cell with more than one nucleus." [FB:ma]
synonym: "syncitium" EXACT []
synonym: "syncytial cell" EXACT []
synonym: "syncytium" EXACT []
xref: AEO:0000203
xref: WBbt:0008074
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001908 ! multinucleate
relationship: has_characteristic PATO:0001908 ! multinucleate

[Term]
id: CL:0000232
name: erythrocyte
def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:D004912]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "RBC" EXACT []
synonym: "red blood cell" EXACT []
xref: BTO:0000424
xref: CALOHA:TS-0290
xref: FMA:81100
is_a: CL:0000081 ! blood cell
is_a: CL:0000329 ! oxygen accumulating cell
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0008015 ! blood circulation
intersection_of: capable_of GO:0015671 ! oxygen transport
intersection_of: CL:4030045 GO:0005840 ! lacks_part ribosome
intersection_of: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
intersection_of: has_characteristic PATO:0002039 ! biconcave
relationship: CL:4030045 GO:0005840 ! lacks_part ribosome
relationship: CL:4030046 PR:000001945 ! lacks_plasma_membrane_part transferrin receptor protein 1
relationship: develops_from CL:0000558 ! reticulocyte
relationship: has_characteristic PATO:0002039 ! biconcave
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000234
name: phagocyte
def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
xref: BTO:0001044
xref: FMA:83806
xref: MESH:D010586
is_a: CL:0000219 ! motile cell
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0000473 ! defensive cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0006909 ! phagocytosis
relationship: capable_of GO:0006909 ! phagocytosis

[Term]
id: CL:0000255
name: eukaryotic cell
def: "Any cell that in taxon some Eukaryota." [FBC:Autogenerated]
subset: cellxgene_subset
xref: MESH:D005057
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: in_taxon NCBITaxon:2759 ! Eukaryota
intersection_of: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: in_taxon NCBITaxon:2759 ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota

[Term]
id: CL:0000257
name: Eumycetozoan cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: only_in_taxon NCBITaxon:142796 ! Eumycetozoa
relationship: only_in_taxon NCBITaxon:142796 ! Eumycetozoa

[Term]
id: CL:0000287
name: eye photoreceptor cell
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000970 ! eye
relationship: part_of UBERON:0000970 ! eye
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000293
name: structural cell
def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr]
is_a: CL:0000000 ! cell

[Term]
id: CL:0000300
name: gamete
def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544]
synonym: "haploid germ cell" RELATED []
synonym: "haploid nucleated cell" EXACT []
xref: CALOHA:TS-0395
xref: FBbt:00005412
xref: FMA:18649
is_a: CL:0000413 ! haploid cell
is_a: CL:0000586 {is_inferred="true"} ! germ cell
intersection_of: CL:0000586 ! germ cell
intersection_of: capable_of GO:0009566 ! fertilization
intersection_of: has_characteristic PATO:0001375 ! haploid
relationship: capable_of GO:0009566 ! fertilization

[Term]
id: CL:0000306
name: crystallin accumulating cell
subset: eye_upper_slim
synonym: "lens cell" EXACT []
is_a: CL:0000325 ! stuff accumulating cell

[Term]
id: CL:0000313
name: serous secreting cell
def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544]
subset: cellxgene_subset
synonym: "serous cell" EXACT []
xref: BTO:0003687
xref: FMA:62511
is_a: CL:0000159 ! seromucus secreting cell

[Term]
id: CL:0000319
name: mucus secreting cell
subset: cellxgene_subset
synonym: "mucous cell" EXACT []
xref: BTO:0003689
is_a: CL:0000159 ! seromucus secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0070254 ! mucus secretion
relationship: capable_of GO:0070254 ! mucus secretion

[Term]
id: CL:0000325
name: stuff accumulating cell
def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma]
subset: ubprop:upper_level
is_a: CL:0000000 ! cell

[Term]
id: CL:0000327
name: extracellular matrix secreting cell
is_a: CL:0000499 ! stromal cell

[Term]
id: CL:0000329
name: oxygen accumulating cell
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0015671 ! oxygen transport
relationship: capable_of GO:0015671 ! oxygen transport

[Term]
id: CL:0000333
name: migratory neural crest cell
def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017]
xref: FMA:86667
is_a: CL:0000219 ! motile cell
is_a: CL:0011012 ! neural crest cell
is_a: CL:0011026 ! progenitor cell
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from CL:0007004 ! premigratory neural crest cell

[Term]
id: CL:0000335
name: mesenchyme condensation cell
def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404]
is_a: CL:0008019 ! mesenchymal cell

[Term]
id: CL:0000347
name: scleral cell
def: "A cell of the sclera of the eye." [GOC:add]
subset: eye_upper_slim
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000293 ! structural cell
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001773 ! sclera
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001773 ! sclera

[Term]
id: CL:0000348
name: choroidal cell of the eye
def: "A structural cell that is part of optic choroid." [GOC:add]
subset: eye_upper_slim
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000293 ! structural cell
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000293 ! structural cell
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001776 ! optic choroid

[Term]
id: CL:0000349
name: extraembryonic cell
subset: general_cell_types_upper_slim
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000478 ! extraembryonic structure
relationship: part_of UBERON:0000478 ! extraembryonic structure

[Term]
id: CL:0000351
name: trophoblast cell
def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:D014327]
synonym: "trophoblastic cell" EXACT []
xref: FMA:83028
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
relationship: part_of UBERON:0000358 ! blastocyst

[Term]
id: CL:0000352
name: epiblast cell
def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256]
is_a: CL:0000052 ! totipotent stem cell

[Term]
id: CL:0000353
name: blastoderm cell
def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:D001756]
synonym: "blastomere" EXACT []
xref: BTO:0001473
xref: FMA:72551
is_a: CL:0000007 ! early embryonic cell (metazoa)

[Term]
id: CL:0000354
name: blastemal cell
synonym: "blastema cell" EXACT []
xref: ncithesaurus:Blastemal_Cell
is_a: CL:0000048 ! multi fate stem cell

[Term]
id: CL:0000355
name: multi-potent skeletal muscle stem cell
def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell." [PMID:18282570]
comment: Multi-potency demonstrated ex vivo.  At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo.
xref: FMA:86767
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0000188 ! cell of skeletal muscle
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0000358
name: sphincter associated smooth muscle cell
def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004590 ! sphincter muscle
relationship: part_of UBERON:0004590 ! sphincter muscle

[Term]
id: CL:0000359
name: vascular associated smooth muscle cell
def: "A smooth muscle cell associated with the vasculature." [GOC:dsd, GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "vascular smooth muscle cell" EXACT []
synonym: "VSMC" EXACT []
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:4033054 ! perivascular cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002049 ! vasculature
relationship: part_of UBERON:0002049 ! vasculature
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000362
name: epidermal cell
def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma]
subset: cellxgene_subset
synonym: "cell of epidermis" EXACT [FMA:62411]
synonym: "epithelial cell of skin" NARROW [FMA:62411]
xref: BTO:0001470
xref: CALOHA:TS-0283
xref: FMA:62411
xref: MESH:D000078404
xref: ZFA:0009183 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0007376 ! outer epithelium
relationship: part_of UBERON:0007376 ! outer epithelium

[Term]
id: CL:0000365
name: animal zygote
def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208]
synonym: "zygote" BROAD []
xref: BTO:0000854
xref: EHDAA2:0004546
xref: FMA:72395
is_a: CL:0000007 ! early embryonic cell (metazoa)
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0010017 ! zygote
intersection_of: CL:0010017 ! zygote
intersection_of: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: CL:0000393
name: electrically responsive cell
def: "A cell whose function is determined by its response to an electric signal." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000397
name: ganglion interneuron
subset: cellxgene_subset
is_a: CL:0000099 {is_inferred="true"} ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: has_soma_location UBERON:0000045 ! ganglion
relationship: has_soma_location UBERON:0000045 ! ganglion

[Term]
id: CL:0000402
name: CNS interneuron
def: "An interneuron that has its cell body in a central nervous system." [doi:10.1016/B978-0-12-817424-1.00001-X]
comment: Interneurons are commonly described as being only found in the central nervous system. However, in CL we define 'interneuron' more broadly as any neuron that is neither a motor neuron nor a sensory neuron, regardless of its location, so we need this term to refer strictly to interneurons of the central nervous system.
subset: human_reference_atlas
is_a: CL:0000099 ! interneuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000099 ! interneuron
intersection_of: has_soma_location UBERON:0001017 ! central nervous system
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000404
name: electrically signaling cell
def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma]
is_a: CL:0000211 ! electrically active cell

[Term]
id: CL:0000408
name: male gamete
xref: BTO:0001277
xref: CALOHA:TS-0949
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000300 {is_inferred="true"} ! gamete
intersection_of: CL:0000015 ! male germ cell
intersection_of: capable_of GO:0009566 ! fertilization
intersection_of: has_characteristic PATO:0001375 ! haploid

[Term]
id: CL:0000412
name: polyploid cell
def: "A cell that contains more than two haploid sets of chromosomes." [FB:ma, https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy, PMID:32646579]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001377 ! polyploid
relationship: has_characteristic PATO:0001377 ! polyploid

[Term]
id: CL:0000413
name: haploid cell
def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0001375 ! haploid
relationship: has_characteristic PATO:0001375 ! haploid

[Term]
id: CL:0000417
name: endopolyploid cell
is_a: CL:0000412 ! polyploid cell

[Term]
id: CL:0000447
name: carbohydrate secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000451
name: dendritic cell
def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "interdigitating cell" RELATED []
synonym: "veiled cell" RELATED []
xref: BTO:0002042
xref: CALOHA:TS-0194
xref: FMA:83036
xref: MESH:D003713
is_a: CL:0000113 ! mononuclear phagocyte
is_a: CL:0000145 ! professional antigen presenting cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000738 ! leukocyte
intersection_of: capable_of GO:0001816 ! cytokine production
intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: capable_of GO:0019882 ! antigen processing and presentation
intersection_of: capable_of GO:0045580 ! regulation of T cell differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: has_characteristic PATO:0001407 ! mononucleate
intersection_of: has_part GO:0042613 ! MHC class II protein complex
disjoint_from: CL:0000542 ! lymphocyte
relationship: capable_of GO:0001816 ! cytokine production
relationship: capable_of GO:0045580 ! regulation of T cell differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: has_part GO:0042613 ! MHC class II protein complex
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000457
name: biogenic amine secreting cell
is_a: CL:0000151 ! secretory cell

[Term]
id: CL:0000458
name: serotonin secreting cell
def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576]
synonym: "5-HT secreting cell" EXACT []
synonym: "5-Hydroxytryptamine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0001820 ! serotonin secretion
relationship: capable_of GO:0001820 ! serotonin secretion

[Term]
id: CL:0000459
name: noradrenergic cell
def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X]
synonym: "noradrenaline secreting cell" EXACT []
synonym: "norepinephrin secreting cell" EXACT []
synonym: "norepinephrine secreting cell" EXACT []
is_a: CL:0000457 ! biogenic amine secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0048243 ! norepinephrine secretion
relationship: capable_of GO:0048243 ! norepinephrine secretion

[Term]
id: CL:0000473
name: defensive cell
def: "A cell whose primary function is to protect the organism." [JB:jb]
is_a: CL:0000000 ! cell

[Term]
id: CL:0000488
name: visible light photoreceptor cell
def: "A photoreceptor cell that detects visible light." [GOC:tfm]
is_a: CL:0000210 ! photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: capable_of GO:0009584 ! detection of visible light
relationship: capable_of GO:0009584 ! detection of visible light

[Term]
id: CL:0000499
name: stromal cell
def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:D017154]
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
xref: BTO:0002064
xref: FMA:83624
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000502
name: type D enteroendocrine cell
def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:D019864]
subset: cellxgene_subset
synonym: "D cell" EXACT []
xref: FMA:62935
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000172 ! somatostatin secreting cell

[Term]
id: CL:0000506
name: enkephalin secreting cell
def: "An endorphine cell that secretes enkephalin." [GO:tfm]
is_a: CL:0000507 ! endorphin secreting cell

[Term]
id: CL:0000507
name: endorphin secreting cell
def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm]
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000508
name: type G enteroendocrine cell
def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:D019863]
subset: cellxgene_subset
synonym: "G cell" EXACT []
xref: BTO:0004108
xref: FMA:67609
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000506 ! enkephalin secreting cell
is_a: CL:0000509 ! gastrin secreting cell
is_a: CL:0002180 ! mucous cell of stomach
relationship: part_of UBERON:0004997 ! mucosa of pyloric antrum

[Term]
id: CL:0000509
name: gastrin secreting cell
def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm]
subset: human_reference_atlas
is_a: CL:0000167 ! peptide hormone secreting cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000511
name: androgen binding protein secreting cell
def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm]
is_a: CL:0000154 ! protein secreting cell

[Term]
id: CL:0000513
name: cardiac muscle myoblast
def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:D032386]
subset: cellxgene_subset
synonym: "cardiac muscle progenitor cell" EXACT []
synonym: "cardiomyocyte progenitor cell" EXACT []
xref: FMA:84797
is_a: CL:0002494 ! cardiocyte
is_a: CL:0010021 ! cardiac myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue
relationship: part_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: CL:0000514
name: smooth muscle myoblast
def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:D032390]
subset: cellxgene_subset
synonym: "myoblast, smooth muscle" EXACT [MESH:D032390]
synonym: "satellite cell" RELATED []
xref: FMA:84798
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000192 ! smooth muscle cell
relationship: develops_into CL:0000192 ! smooth muscle cell

[Term]
id: CL:0000515
name: skeletal muscle myoblast
def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl]
synonym: "skeletal myoblast" EXACT []
xref: FMA:84799
is_a: CL:0000056 ! myoblast
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000355 ! multi-potent skeletal muscle stem cell
relationship: develops_into CL:0008002 ! skeletal muscle fiber

[Term]
id: CL:0000518
name: phagocyte (sensu Vertebrata)
def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm]
is_a: CL:0000234 ! phagocyte
is_a: CL:0000255 ! eukaryotic cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: CL:0000521
name: fungal cell
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: only_in_taxon NCBITaxon:4751 ! Fungi
relationship: only_in_taxon NCBITaxon:4751 ! Fungi

[Term]
id: CL:0000525
name: syncytiotrophoblast cell
def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "plasmidotrophoblast cell" RELATED []
synonym: "syncytial trophoblast cell" EXACT [PMID:11787150]
synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368]
synonym: "syntrophoblast cell" RELATED []
xref: FMA:83043
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000351 ! trophoblast cell
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: has_characteristic PATO:0001908 ! multinucleate
relationship: part_of UBERON:0000371 ! syncytiotrophoblast
property_value: RO:0002175 NCBITaxon:9606
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" xsd:string

[Term]
id: CL:0000526
name: afferent neuron
def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:D009475]
subset: human_reference_atlas
synonym: "input neuron" EXACT []
xref: FMA:87653
is_a: CL:0000540 ! neuron
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000527
name: efferent neuron
def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:D009476]
synonym: "output neuron" EXACT []
is_a: CL:0000540 ! neuron

[Term]
id: CL:0000540
name: neuron
def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:D009474]
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "nerve cell" EXACT []
xref: BTO:0000938
xref: CALOHA:TS-0683
xref: FBbt:00005106
xref: FMA:54527
xref: VHOG:0001483
xref: WBbt:0003679
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0000404 ! electrically signaling cell
is_a: CL:0002319 ! neural cell
relationship: capable_of GO:0019226 ! transmission of nerve impulse
relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata)
property_value: depiction "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000542
name: lymphocyte
def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149]
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0000775
xref: CALOHA:TS-0583
xref: FMA:62863
xref: MESH:D008214
xref: VHOG:0001535
is_a: CL:0000842 ! mononuclear cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_characteristic PATO:0001407 ! mononucleate
intersection_of: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio
intersection_of: has_part CL:0017500 ! neutrophillic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
disjoint_from: CL:0000766 ! myeloid leukocyte
relationship: develops_from CL:0000051 ! common lymphoid progenitor
relationship: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio
relationship: has_part CL:0017500 ! neutrophillic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000547
name: proerythroblast
def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_characteristic PATO:0002505 ! nucleated
intersection_of: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0005730 ! nucleolus
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000038 ! erythroid progenitor cell
relationship: has_characteristic PATO:0040072 ! high nuclear/cytoplasmic ratio
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0005730 ! nucleolus
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000549
name: basophilic erythroblast
def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464]
synonym: "basophilic normoblast" EXACT [ISBN:0721601464]
synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017503 ! basophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: has_part CL:0017503 ! basophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000550
name: polychromatophilic erythroblast
def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464]
synonym: "intermediate erythroblast" EXACT [ISBN:0721601464]
synonym: "intermediate normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464]
synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017504 ! polychromatophilic cytoplasm
intersection_of: has_part GO:0000792 ! heterochromatin
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: develops_from CL:0000549 ! basophilic erythroblast
relationship: has_part CL:0017504 ! polychromatophilic cytoplasm
relationship: has_part GO:0000792 ! heterochromatin
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000552
name: orthochromatic erythroblast
def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464]
synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464]
synonym: "late erythoblast" EXACT []
synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464]
synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464]
xref: FMA:84646
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
intersection_of: CL:0000765 ! erythroblast
intersection_of: has_part CL:0017502 ! acidophilic cytoplasm
intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation
relationship: develops_from CL:0000550 ! polychromatophilic erythroblast
relationship: has_part CL:0017502 ! acidophilic cytoplasm
relationship: participates_in GO:0030263 ! apoptotic chromosome condensation

[Term]
id: CL:0000553
name: megakaryocyte progenitor cell
def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
synonym: "colony-forming unit-megakaryocyte" EXACT []
synonym: "Meg-CFC" EXACT [PMCID:PMC1794060]
synonym: "megacaryoblast" EXACT []
synonym: "megacaryocyte progenitor cell" EXACT []
synonym: "megakaryoblast" EXACT []
synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498]
synonym: "MkP" EXACT [PMID:21116988]
synonym: "promegacaryocyte" RELATED []
synonym: "promegakaryocyte" RELATED []
xref: BTO:0001164
xref: CALOHA:TS-0610
xref: FMA:84235
xref: MESH:D055016
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell
intersection_of: capable_of GO:0007113 ! endomitotic cell cycle
intersection_of: capable_of GO:0030219 ! megakaryocyte differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: capable_of GO:0007113 ! endomitotic cell cycle
relationship: capable_of GO:0030219 ! megakaryocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000556
name: megakaryocyte
def: "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533, PMID:31043076]
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "megacaryocyte" EXACT []
synonym: "megalocaryocyte" EXACT []
synonym: "megalokaryocyte" EXACT []
xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell
relationship: has_characteristic PATO:0001393 ! euploid
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000558
name: reticulocyte
def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
xref: BTO:0001173
xref: CALOHA:TS-0864
xref: MESH:D012156
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0071971 ! extracellular exosome assembly
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: capable_of GO:0071971 ! extracellular exosome assembly
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000552 ! orthochromatic erythroblast
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0000562
name: nucleate erythrocyte
def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm]
synonym: "RBC" BROAD []
synonym: "red blood cell" BROAD []
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000232 ! erythrocyte
intersection_of: has_characteristic PATO:0002505 ! nucleated
relationship: develops_from CL:0002421 ! nucleated reticulocyte

[Term]
id: CL:0000566
name: angioblastic mesenchymal cell
def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5
intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2
intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5
relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2
relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1

[Term]
id: CL:0000569
name: cardiac mesenchymal cell
def: "A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field." [PMID:18816864]
subset: cellxgene_subset
is_a: CL:0008019 ! mesenchymal cell
is_a: CL:2000073 ! migratory cardiac neural crest cell
intersection_of: CL:0008019 ! mesenchymal cell
intersection_of: develops_into CL:0002494 ! cardiocyte
relationship: develops_into CL:0002494 ! cardiocyte

[Term]
id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000575
name: corneal epithelial cell
def: "An epithelial cell of the cornea." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "epithelial cell of cornea" EXACT [FMA:70551]
xref: BTO:0004298
xref: CALOHA:TS-0173
xref: FMA:70551
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002159 ! general ecto-epithelial cell
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0001772 ! corneal epithelium
relationship: part_of UBERON:0001772 ! corneal epithelium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000586
name: germ cell
def: "The reproductive cell in multicellular organisms." [MESH:D005854]
subset: cellxgene_subset
xref: BTO:0000535
xref: NCIT:C12597
xref: VHOG:0001534
xref: WBbt:0006796
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
relationship: capable_of_part_of GO:0009566 ! fertilization

[Term]
id: CL:0000593
name: androgen secreting cell
def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm]
is_a: CL:0000174 ! steroid hormone secreting cell
intersection_of: CL:0000151 ! secretory cell
intersection_of: capable_of GO:0035935 ! androgen secretion
relationship: capable_of GO:0035935 ! androgen secretion

[Term]
id: CL:0000595
name: enucleate erythrocyte
def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm]
subset: cellxgene_subset
synonym: "RBC" RELATED OMO:0003000 []
synonym: "red blood cell" BROAD []
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000232 {is_inferred="true"} ! erythrocyte
intersection_of: CL:0000232 ! erythrocyte
intersection_of: has_characteristic PATO:0001405 ! anucleate
relationship: develops_from CL:0002422 ! enucleated reticulocyte

[Term]
id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
is_a: CL:0010009 ! camera-type eye photoreceptor cell
relationship: develops_from CL:0002672 ! retinal progenitor cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000622
name: acinar cell
def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de]
subset: cellxgene_subset
synonym: "acinic cell" EXACT []
synonym: "acinous cell" EXACT []
xref: FMA:83625
xref: MESH:D061354
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000154 ! protein secreting cell
relationship: part_of UBERON:0009842 ! glandular acinus

[Term]
id: CL:0000630
name: supporting cell
def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm]
subset: cellxgene_subset
synonym: "supportive cell" EXACT []
xref: BTO:0002315
is_a: CL:0000000 ! cell

[Term]
id: CL:0000656
name: primary spermatocyte
def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544]
xref: BTO:0001115
xref: CALOHA:TS-2194
xref: FMA:72292
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: capable_of GO:0007140 ! male meiotic nuclear division
intersection_of: has_characteristic PATO:0001394 ! diploid
relationship: capable_of GO:0007140 ! male meiotic nuclear division
relationship: has_characteristic PATO:0001394 ! diploid

[Term]
id: CL:0000657
name: secondary spermatocyte
def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544]
xref: BTO:0000709
xref: CALOHA:TS-2195
xref: FBbt:00004941
xref: FMA:72293
is_a: CL:0000017 ! spermatocyte
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000413 ! haploid cell
intersection_of: CL:0000017 ! spermatocyte
intersection_of: capable_of GO:0007142 ! male meiosis II
intersection_of: has_characteristic PATO:0001375 ! haploid
relationship: capable_of GO:0007142 ! male meiosis II
relationship: develops_from CL:0000656 ! primary spermatocyte

[Term]
id: CL:0000667
name: collagen secreting cell
def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000327 ! extracellular matrix secreting cell

[Term]
id: CL:0000670
name: primordial germ cell
def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289]
subset: cellxgene_subset
synonym: "gonocyte" EXACT []
synonym: "primitive germ cell" EXACT []
xref: FMA:70567
is_a: CL:0000039 {is_inferred="true"} ! germ line cell
is_a: CL:0000219 {is_inferred="true"} ! motile cell
intersection_of: CL:0000039 ! germ line cell
intersection_of: capable_of GO:0048870 ! cell motility
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo

[Term]
id: CL:0000675
name: female gamete
def: "A mature sexual reproductive cell of the female germline." [GOC:tfm]
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
is_a: CL:0000300 ! gamete

[Term]
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
subset: cellxgene_subset
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000255 ! eukaryotic cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_into CL:0000187 ! muscle cell
relationship: develops_from CL:0000222 ! mesodermal cell
relationship: develops_into CL:0000187 ! muscle cell

[Term]
id: CL:0000696
name: PP cell
def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415]
subset: cellxgene_subset
synonym: "type F enteroendocrine cell" EXACT []
xref: FMA:62938
xref: FMA:83409
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000167 ! peptide hormone secreting cell

[Term]
id: CL:0000710
name: neurecto-epithelial cell
def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm]
comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098).
synonym: "neuroepithelial cell" BROAD []
xref: BTO:0004301
xref: FMA:70557
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002077 ! ecto-epithelial cell
intersection_of: CL:0002077 ! ecto-epithelial cell
intersection_of: develops_from CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000133 ! neurectodermal cell

[Term]
id: CL:0000723
name: somatic stem cell
def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103]
xref: CALOHA:TS-2086
xref: MESH:D053687
is_a: CL:0000034 ! stem cell
intersection_of: CL:0000034 ! stem cell
intersection_of: capable_of GO:0048103 ! somatic stem cell division
relationship: capable_of GO:0048103 ! somatic stem cell division

[Term]
id: CL:0000737
name: striated muscle cell
def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544]
xref: BTO:0002916
xref: CALOHA:TS-2157
xref: FMA:86936
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_characteristic PATO:0001410 ! striated
intersection_of: has_part GO:0030017 ! sarcomere
disjoint_from: CL:0008000 ! non-striated muscle cell
relationship: has_characteristic PATO:0001410 ! striated
relationship: has_part GO:0030017 ! sarcomere

[Term]
id: CL:0000738
name: leukocyte
def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "immune cell" RELATED []
synonym: "leucocyte" EXACT []
synonym: "white blood cell" EXACT []
xref: BTO:0000751
xref: CALOHA:TS-0549
xref: FMA:62852
xref: MESH:D007962
xref: NCIT:C12529
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: capable_of GO:0001667 ! ameboidal-type cell migration
intersection_of: has_characteristic PATO:0002505 ! nucleated
relationship: capable_of GO:0001667 ! ameboidal-type cell migration
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0002405 ! immune system
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000740
name: retinal ganglion cell
def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
synonym: "RGC" RELATED OMO:0003000 [doi:10.1038/s41598-020-66092-9]
synonym: "RGCs" RELATED OMO:0003004 [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
is_a: CL:0000117 ! CNS neuron (sensu Vertebrata)
relationship: has_soma_location UBERON:0000966 ! retina
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000746
name: cardiac muscle cell
alt_id: FMA:83808
def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908, PMID:22426062, PMID:4711263]
comment: This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods.  The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein).  According to these refs, the cells participating in heart contraction in all cases are transversely striated.  Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.
subset: cellxgene_subset
subset: general_cell_types_upper_slim
subset: human_reference_atlas
synonym: "cardiac muscle fiber" EXACT [GO:0048739]
synonym: "cardiac myocyte" EXACT []
synonym: "cardiocyte" BROAD []
synonym: "cardiomyocyte" EXACT []
synonym: "heart muscle cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:14067
xref: MESH:D032383
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_characteristic PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
intersection_of: participates_in GO:0060047 ! heart contraction
relationship: develops_from CL:0000513 ! cardiac muscle myoblast
relationship: has_characteristic PATO:0002478 ! transversely striated
relationship: participates_in GO:0060047 ! heart contraction
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000763
name: myeloid cell
def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add]
subset: cellxgene_subset
xref: BTO:0001441
xref: CALOHA:TS-0647
xref: MESH:D022423
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
relationship: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000764
name: erythroid lineage cell
def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm]
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "erythropoietic cell" EXACT []
xref: CALOHA:TS-0290
xref: FMA:62845
xref: FMA:83516
is_a: CL:0000763 ! myeloid cell
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000765
name: erythroblast
def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "normoblast" EXACT []
xref: BTO:0001571
xref: CALOHA:TS-0289
xref: FMA:83504
xref: MESH:D004900
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0000764 ! erythroid lineage cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: CL:4030045 GO:0005730 ! lacks_part nucleolus
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_part GO:0005634 ! nucleus
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: CL:4030045 GO:0005730 ! lacks_part nucleolus
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: develops_from CL:0000547 ! proerythroblast
relationship: has_part GO:0005634 ! nucleus

[Term]
id: CL:0000766
name: myeloid leukocyte
def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add]
subset: cellxgene_subset
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
is_a: CL:0000763 ! myeloid cell
intersection_of: CL:0000738 ! leukocyte
intersection_of: develops_from CL:0000049 ! common myeloid progenitor

[Term]
id: CL:0000783
name: multinucleated phagocyte
def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm]
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata)
intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata)
intersection_of: has_characteristic PATO:0001908 ! multinucleate

[Term]
id: CL:0000827
name: pro-T cell
def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149]
subset: cellxgene_subset
synonym: "DN1 cell" NARROW []
synonym: "DN1 thymocyte" NARROW []
synonym: "pro-T lymphocyte" EXACT []
synonym: "progenitor T cell" EXACT []
synonym: "TN1 cell" NARROW []
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
intersection_of: capable_of GO:0030217 ! T cell differentiation
relationship: capable_of GO:0030217 ! T cell differentiation
relationship: develops_from CL:0000051 ! common lymphoid progenitor

[Term]
id: CL:0000837
name: hematopoietic multipotent progenitor cell
def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770]
comment: Markers differ between mouse and human.
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: has_characteristic PATO:0001402 ! multipotent
intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001869 ! lacks_plasma_membrane_part interleukin-7 receptor subunit alpha
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
relationship: develops_from CL:0000037 ! hematopoietic stem cell
relationship: has_characteristic PATO:0001402 ! multipotent
relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000838
name: lymphoid lineage restricted progenitor cell
def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
synonym: "lymphoid progenitor cell" BROAD []
xref: BTO:0004731
xref: CALOHA:TS-2025
xref: FMA:70338
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030098 ! lymphocyte differentiation
disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: capable_of GO:0030098 ! lymphocyte differentiation

[Term]
id: CL:0000839
name: myeloid lineage restricted progenitor cell
def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770]
comment: Note that this is a class of cell types, not an identified single cell type.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "myeloid progenitor cell" BROAD []
xref: BTO:0004730
xref: CALOHA:TS-2099
xref: FMA:70339
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: CL:0011026 ! progenitor cell
intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell
intersection_of: capable_of GO:0030099 ! myeloid cell differentiation
relationship: capable_of GO:0030099 ! myeloid cell differentiation
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0000842
name: mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
subset: blood_and_immune_upper_slim
subset: cellxgene_subset
synonym: "mononuclear leukocyte" EXACT []
synonym: "peripheral blood mononuclear cell" NARROW []
xref: BTO:0000878
xref: CALOHA:TS-0768
xref: FMA:86713
is_a: CL:0000226 ! single nucleate cell
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: has_characteristic PATO:0001407 ! mononucleate

[Term]
id: CL:0000850
name: serotonergic neuron
def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl]
synonym: "5-HT neuron" EXACT []
synonym: "5-hydroxytryptamine neuron" EXACT []
synonym: "serotinergic neuron" RELATED []
xref: FBbt:00005133
xref: MESH:D059326
xref: WBbt:0006837
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0060096 ! serotonin secretion, neurotransmission
relationship: capable_of GO:0060096 ! serotonin secretion, neurotransmission

[Term]
id: CL:0000988
name: hematopoietic cell
def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add]
subset: cellxgene_subset
synonym: "haematopoietic cell" EXACT []
synonym: "haemopoietic cell" EXACT []
synonym: "hemopoietic cell" EXACT []
xref: BTO:0000574
xref: CALOHA:TS-2017
xref: FMA:70366
xref: FMA:83598
is_a: CL:0000000 ! cell

[Term]
id: CL:0001035
name: bone cell
def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add]
subset: general_cell_types_upper_slim
subset: human_reference_atlas
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001474 ! bone element
relationship: part_of UBERON:0001474 ! bone element
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0001-9990-8331
creation_date: 2011-11-16T04:28:16Z

[Term]
id: CL:0001060
name: hematopoietic oligopotent progenitor cell, lineage-negative
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770]
is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
intersection_of: has_characteristic PATO:0001401 ! oligopotent
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: CL:4030046 PR:000002981 ! lacks_plasma_membrane_part lymphocyte antigen 76 (mouse)
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0001066
name: erythroid progenitor cell, mammalian
def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464]
subset: cellxgene_subset
synonym: "BFU-E" RELATED OMO:0003000 []
synonym: "blast forming unit erythroid" RELATED []
synonym: "burst forming unit erythroid" RELATED []
synonym: "CFU-E" RELATED OMO:0003000 []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
is_a: CL:0000038 ! erythroid progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000038 ! erythroid progenitor cell
intersection_of: capable_of GO:0030218 ! erythrocyte differentiation
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
intersection_of: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
intersection_of: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
intersection_of: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
intersection_of: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
intersection_of: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
intersection_of: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
intersection_of: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1
relationship: capable_of GO:0030218 ! erythrocyte differentiation
relationship: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
relationship: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
relationship: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
relationship: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
relationship: CL:4030046 PR:000001024 ! lacks_plasma_membrane_part neural cell adhesion molecule 1
relationship: CL:4030046 PR:000001083 ! lacks_plasma_membrane_part CD2 molecule
relationship: CL:4030046 PR:000001084 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD8 alpha chain
relationship: CL:4030046 PR:000001289 ! lacks_plasma_membrane_part membrane-spanning 4-domains subfamily A member 1
relationship: CL:4030046 PR:000001839 ! lacks_plasma_membrane_part T-cell surface glycoprotein CD5
relationship: CL:4030046 PR:000001889 ! lacks_plasma_membrane_part CD14 molecule
relationship: CL:4030046 PR:000002978 ! lacks_plasma_membrane_part lymphocyte antigen 6G
relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1

[Term]
id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
subset: blood_and_immune_upper_slim
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: has_characteristic PATO:0001400 ! unipotent
disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell
relationship: has_characteristic PATO:0001400 ! unipotent
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-01-06T03:43:20Z

[Term]
id: CL:0002032
name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell.  For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
subset: blood_and_immune_upper_slim
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: has_characteristic PATO:0001401 ! oligopotent
relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell
relationship: has_characteristic PATO:0001401 ! oligopotent
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-01-06T03:43:27Z

[Term]
id: CL:0002064
name: pancreatic acinar cell
def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "acinar cell of pancreas" EXACT []
xref: BTO:0000028
xref: CALOHA:TS-0737
xref: FMA:63032
is_a: CL:0000622 {is_inferred="true"} ! acinar cell
is_a: CL:1001599 ! pancreas exocrine glandular cell
intersection_of: CL:0000622 ! acinar cell
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: has_part GO:0042589 ! zymogen granule membrane
relationship: part_of UBERON:0001263 ! pancreatic acinus
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-24T03:16:29Z

[Term]
id: CL:0002067
name: type A enteroendocrine cell
def: "An enteroendocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911]
xref: FMA:62939
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000170 ! glucagon secreting cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: capable_of GO:0070091 ! glucagon secretion
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T10:48:54Z

[Term]
id: CL:0002068
name: Purkinje myocyte
def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742]
subset: human_reference_atlas
synonym: "myocytus conducens cardiacus" EXACT []
synonym: "Purkinje cell fiber" EXACT []
synonym: "Purkinje muscle cell" EXACT []
xref: BTO:0001032
xref: FMA:14146
is_a: CL:0002086 ! specialized cardiac myocyte
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-28T08:36:15Z

[Term]
id: CL:0002072
name: nodal myocyte
def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm]
synonym: "cardiac pacemaker cell" EXACT [GOC:pr]
synonym: "myocytus nodalis" EXACT []
synonym: "P cell" EXACT []
synonym: "pacemaker cell" BROAD []
xref: BTO:0004190
xref: FMA:67101
is_a: CL:0002086 ! specialized cardiac myocyte
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T11:41:37Z

[Term]
id: CL:0002073
name: transitional myocyte
def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm]
xref: FMA:67142
is_a: CL:0002086 ! specialized cardiac myocyte
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T02:39:32Z

[Term]
id: CL:0002074
name: myocardial endocrine cell
def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm]
xref: FMA:67111
is_a: CL:0000163 ! endocrine cell
is_a: CL:0002086 ! specialized cardiac myocyte
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T11:50:47Z

[Term]
id: CL:0002076
name: endo-epithelial cell
def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm]
xref: FMA:69075
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: develops_from CL:0000223 ! endodermal cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T03:38:14Z

[Term]
id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
xref: FMA:69074
xref: ZFA:0009385 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000221 ! ectodermal cell
relationship: develops_from CL:0000221 ! ectodermal cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T03:38:22Z

[Term]
id: CL:0002078
name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: develops_from CL:0000222 ! mesodermal cell
relationship: develops_from CL:0000222 ! mesodermal cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-29T03:49:14Z

[Term]
id: CL:0002079
name: pancreatic ductal cell
def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:63099
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: part_of UBERON:0001064 ! ventral pancreatic duct
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-30T08:49:43Z

[Term]
id: CL:0002080
name: pancreatic centro-acinar cell
def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160]
subset: human_reference_atlas
synonym: "centroacinar cell of Langerhans" EXACT []
synonym: "pancreatic centroacinar cell" EXACT []
xref: FMA:62455
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000083 ! epithelial cell of pancreas
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0001263 ! pancreatic acinus
relationship: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
relationship: part_of UBERON:0001263 ! pancreatic acinus
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-06-30T08:49:52Z

[Term]
id: CL:0002086
name: specialized cardiac myocyte
def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm]
xref: FMA:67968
is_a: CL:0000746 ! cardiac muscle cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-21T01:33:38Z

[Term]
id: CL:0002087
name: nongranular leukocyte
def: "A leukocyte that lacks granules." [GOC:tfm]
subset: blood_and_immune_upper_slim
synonym: "agranular leukocyte" EXACT []
xref: FMA:62855
is_a: CL:0000738 {is_inferred="true"} ! leukocyte
intersection_of: CL:0000738 ! leukocyte
intersection_of: CL:4030045 GO:0030141 ! lacks_part secretory granule
relationship: CL:4030045 GO:0030141 ! lacks_part secretory granule
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-22T11:30:33Z

[Term]
id: CL:0002088
name: interstitial cell of Cajal
def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112]
comment: Some argue this cell type is of mesenchymal origin.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "ICC" EXACT []
synonym: "intestinal pacemaker cell" EXACT [GOC:pr]
xref: BTO:0003914
xref: FMA:86573
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
intersection_of: CL:0000710 ! neurecto-epithelial cell
intersection_of: capable_of GO:0043134 ! regulation of hindgut contraction
relationship: capable_of GO:0043134 ! regulation of hindgut contraction
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-22T03:26:00Z

[Term]
id: CL:0002092
name: bone marrow cell
def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256]
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.
subset: cellxgene_subset
xref: BTO:0004850
xref: FMA:83621
xref: MESH:D001854
is_a: CL:0001035 {is_inferred="true"} ! bone cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0001035 ! bone cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0002371 ! bone marrow
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-07-22T04:48:15Z

[Term]
id: CL:0002095
name: hilus cell of ovary
def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X]
subset: human_reference_atlas
synonym: "hilar cell of ovary" EXACT []
xref: FMA:18710
is_a: CL:0000593 ! androgen secreting cell
is_a: CL:0002132 ! stromal cell of ovary
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-23T11:18:18Z

[Term]
id: CL:0002132
name: stromal cell of ovary
def: "A stomal cell of the ovary" [GOC:tfm]
subset: cellxgene_subset
synonym: "ovarian stromal cell" EXACT [GOC:cjm]
xref: FMA:72299
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0000992 ! ovary
relationship: part_of UBERON:0000992 ! ovary
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-23T12:10:31Z

[Term]
id: CL:0002139
name: endothelial cell of vascular tree
def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659]
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.
subset: cellxgene_subset
synonym: "cubodial endothelial cell of vascular tree" NARROW []
synonym: "vascular endothelial cell" EXACT []
xref: BTO:0001854
xref: CALOHA:TS-1106
xref: FMA:67755
is_a: CL:0000115 ! endothelial cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-24T02:06:40Z

[Term]
id: CL:0002144
name: capillary endothelial cell
def: "An endothelial cell found in capillaries." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0004956
xref: CALOHA:TS-0112
xref: FMA:67756
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001915 ! endothelium of capillary
relationship: part_of UBERON:0001915 ! endothelium of capillary
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-24T10:15:00Z

[Term]
id: CL:0002149
name: epithelial cell of uterus
def: "An epithelial cell of the uterus." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256161
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-24T10:45:54Z

[Term]
id: CL:0002159
name: general ecto-epithelial cell
def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm]
xref: FMA:70556
is_a: CL:0002077 ! ecto-epithelial cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-26T08:31:08Z

[Term]
id: CL:0002178
name: epithelial cell of stomach
def: "An epithelial cell found in the lining of the stomach." [GOC:tfm]
xref: FMA:62948
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: part_of UBERON:0000945 ! stomach
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-25T03:22:08Z

[Term]
id: CL:0002180
name: mucous cell of stomach
def: "A mucous cell in the epithelium of the stomach." [GOC:tfm]
xref: FMA:63464
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0002178 ! epithelial cell of stomach
intersection_of: part_of UBERON:0001199 ! mucosa of stomach
relationship: part_of UBERON:0001199 ! mucosa of stomach
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-25T03:38:51Z

[Term]
id: CL:0002183
name: stem cell of gastric gland
def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651]
xref: FMA:62953
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:0002180 ! mucous cell of stomach
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0000325 ! gastric gland
relationship: part_of UBERON:0000325 ! gastric gland
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-25T03:57:08Z

[Term]
id: CL:0002195
name: hepatic stem cell
def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363]
synonym: "HpSC" RELATED OMO:0003000 [PMID:18442648]
xref: FMA:86577
is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000048 ! multi fate stem cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-08-30T02:00:42Z

[Term]
id: CL:0002222
name: vertebrate lens cell
def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544]
subset: eye_upper_slim
xref: FMA:70950
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000306 ! crystallin accumulating cell
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: part_of UBERON:0000965 ! lens of camera-type eye
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T10:38:03Z

[Term]
id: CL:0002224
name: lens epithelial cell
def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:67559
is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell
is_a: CL:0002222 ! vertebrate lens cell
intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell
intersection_of: part_of UBERON:0001803 ! epithelium of lens
relationship: part_of UBERON:0001803 ! epithelium of lens
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T10:45:47Z

[Term]
id: CL:0002240
name: marrow fibroblast
def: "A fibroblast in the bone marrow." [GOC:tfm]
xref: FMA:84377
is_a: CL:0000057 ! fibroblast
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002371 ! bone marrow
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T02:25:18Z

[Term]
id: CL:0002241
name: pulmonary interstitial fibroblast
def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm]
subset: cellxgene_subset
synonym: "pulmonary myofibroblast" EXACT []
synonym: "pulmonary septal cell" EXACT []
xref: FMA:84467
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001004 ! respiratory system
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: part_of UBERON:0001004 ! respiratory system
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T02:29:38Z

[Term]
id: CL:0002242
name: nucleate cell
def: "A cell containing at least one nucleus." [GOC:tfm]
xref: FMA:67513
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: has_characteristic PATO:0002505 ! nucleated
relationship: has_characteristic PATO:0002505 ! nucleated
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T03:32:33Z

[Term]
id: CL:0002243
name: smooth muscle cell of sphincter of pupil
def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128]
subset: cellxgene_subset
synonym: "smooth muscle fiber of sphincter of pupil" EXACT []
synonym: "smooth muscle fibre of sphincter of pupil" RELATED []
xref: FMA:70611
is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001607 ! sphincter pupillae
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0001607 ! sphincter pupillae
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T08:53:42Z

[Term]
id: CL:0002246
name: peripheral blood stem cell
def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm]
synonym: "PBSC" EXACT []
xref: BTO:0002669
xref: FMA:86711
xref: MESH:D000072916
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
is_a: CL:0000080 ! circulating cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000178 ! blood
relationship: part_of UBERON:0000178 ! blood
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-07T03:57:09Z

[Term]
id: CL:0002251
name: epithelial cell of alimentary canal
def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544]
is_a: CL:0002076 ! endo-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T09:26:53Z

[Term]
id: CL:0002252
name: epithelial cell of esophagus
def: "An epithelial cell of the esophagus." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:63071
is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T09:28:20Z

[Term]
id: CL:0002253
name: epithelial cell of large intestine
def: "An epithelial cell of the large intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "epithelial cell of colon" RELATED []
xref: BTO:0004297
xref: FMA:256157
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T09:28:22Z

[Term]
id: CL:0002254
name: epithelial cell of small intestine
def: "An epithelial cell of the small intestine." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256159
is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell
intersection_of: CL:0002563 ! intestinal epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T09:41:46Z

[Term]
id: CL:0002255
name: stromal cell of endometrium
def: "A stromal cell of the endometrium that is fibroblastic in appearance. During decidualization this cell may differentiate into a decidual stromal cell." [https://doi.org/10.1038/s41591-020-1040-z, PMID:11331626, PMID:30013421, PMID:30309298, Wiki:Decidualization&oldid=908981933#Endometrial_stromal_cells_(ESCs)]
subset: human_reference_atlas
synonym: "endometrial stromal cell" EXACT []
synonym: "endometrial stromal fibroblast" EXACT [PMID:30309298]
xref: CALOHA:TS-1266
xref: FMA:86490
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: has_potential_to_directly_develop_into CL:2000002 ! decidual cell
relationship: part_of UBERON:0002337 ! endometrial stroma
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-08T09:50:04Z

[Term]
id: CL:0002262
name: endothelial cell of sinusoid
def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:63134
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003909 ! sinusoid
relationship: part_of UBERON:0003909 ! sinusoid
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-14T10:57:26Z

[Term]
id: CL:0002264
name: type A cell of stomach
def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm]
xref: FMA:83411
is_a: CL:0002067 ! type A enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0002067 ! type A enteroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T10:54:42Z

[Term]
id: CL:0002265
name: type D cell of colon
def: "A D cell located in the colon." [GOC:tfm]
synonym: "colon D-cell" EXACT []
synonym: "colonic delta cell" EXACT []
synonym: "delta cell of colon" EXACT []
xref: FMA:268744
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0009042 ! enteroendocrine cell of colon
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0001155 ! colon
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T11:37:35Z

[Term]
id: CL:0002266
name: type D cell of small intestine
def: "A type D cell of the small intestine." [GOC:tfm]
synonym: "delta cell of small intestine" EXACT []
synonym: "small intestine D-cell" EXACT []
synonym: "small intestine delta cell" EXACT []
xref: FMA:268736
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0009006 ! enteroendocrine cell of small intestine
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0002108 ! small intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T01:34:22Z

[Term]
id: CL:0002267
name: type D cell of stomach
def: "A type D cell found in the stomach." [GOC:tfm]
synonym: "delta cell of stomach" EXACT []
synonym: "stomach D-cell" EXACT []
synonym: "stomach delta cell" EXACT []
xref: FMA:83410
is_a: CL:0000502 ! type D enteroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000502 ! type D enteroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T01:36:03Z

[Term]
id: CL:0002275
name: pancreatic PP cell
def: "A PP cell located in the islets of the pancreas." [GOC:tfm]
comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell.
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "pancreatic polypeptide-secreting cell" EXACT []
synonym: "PP cell of pancreatic islet" EXACT []
synonym: "PP-cell of pancreatic islet" EXACT []
xref: BTO:0000805
xref: FMA:70588
xref: MESH:D050418
is_a: CL:0000696 ! PP cell
is_a: CL:0008024 ! pancreatic endocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0000006 ! islet of Langerhans
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0000006 ! islet of Langerhans
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-10T03:30:31Z

[Term]
id: CL:0002308
name: epithelial cell of skin gland
def: "An epithelial cell of a skin gland." [GOC:tfm]
synonym: "epithelial cell of gland of skin" EXACT []
xref: FMA:70657
is_a: CL:0002159 ! general ecto-epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002419 ! skin gland
relationship: part_of UBERON:0002419 ! skin gland
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-14T12:00:07Z

[Term]
id: CL:0002319
name: neural cell
def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
xref: CALOHA:TS-2040
xref: FMA:70333
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0001016 ! nervous system
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-15T01:34:57Z

[Term]
id: CL:0002320
name: connective tissue cell
def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256]
subset: cellxgene_subset
xref: CALOHA:TS-2096
xref: FMA:63875
xref: MESH:D003239
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002384 ! connective tissue
relationship: part_of UBERON:0002384 ! connective tissue
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-15T03:01:54Z

[Term]
id: CL:0002321
name: embryonic cell (metazoa)
def: "A cell of the embryo." [FMA:0618947256]
xref: CALOHA:TS-0263
xref: FMA:82840
xref: https://cellxgene.cziscience.com/cellguide/CL_0002321
xref: WBbt:0007028
xref: ZFA:0007089 {sssom:mapping_justification="vocab:UnspecifiedMatching"}
is_a: CL:0000000 ! cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
property_value: term:description "Embryonic cells in metazoans, which include all multicellular animals, are biological units in their earliest developmental stages from conception until the organism is fully formed. \nThey are derived from a fertilized egg, which undergoes a series of cell divisions to produce a multicellular organism. During the early phases of embryonic development, these cells exhibit pluripotency, meaning they possess the potential to differentiate into a diverse array of specialized cell types that constitute different body tissues and structures. \nThe balance between cell proliferation and differentiation in embryonic cells is crucial for successful development. When cells continue to divide without differentiating, overgrowth may occur leading to conditions such as teratomas (tumors of embryonic cells). Conversely, if cell differentiation proceeds at the expense of cell proliferation, developmental anomalies could occur regarding size or mass of the organism or its parts.\n\n(This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.)" xsd:string {xref="DOI:10.1002/iub.1404", xref="DOI:10.1093/molehr/gan048", xref="https://www.ncbi.nlm.nih.gov/books/NBK9906/"}
creation_date: 2010-09-15T03:39:21Z

[Term]
id: CL:0002333
name: neural crest derived adipocyte
def: "An adipocyte derived from a neural crest cell." [GOC:tfm, PMID:17507398]
is_a: CL:0000136 ! adipocyte
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000136 ! adipocyte
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
relationship: develops_from CL:0000005 ! fibroblast neural crest derived
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-20T02:25:25Z

[Term]
id: CL:0002350
name: endocardial cell
def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endocardial endothelial cell" EXACT []
synonym: "endothelial cell of endocardium" EXACT [FMA:75621]
xref: FMA:75621
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002165 ! endocardium
relationship: part_of UBERON:0002165 ! endocardium
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-21T04:33:05Z

[Term]
id: CL:0002351
name: progenitor cell of endocrine pancreas
def: "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494, PMID:22728667]
subset: cellxgene_subset
synonym: "pancreatic endocrine progenitor" EXACT []
synonym: "pancreatic islet progenitor cell" EXACT []
is_a: CL:0011026 ! progenitor cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-21T04:41:06Z

[Term]
id: CL:0002352
name: gestational hematopoietic stem cell
def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6]
is_a: CL:0000037 ! hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-22T09:05:13Z

[Term]
id: CL:0002359
name: placental hematopoietic stem cell
def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6]
is_a: CL:0002352 ! gestational hematopoietic stem cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-22T10:30:02Z

[Term]
id: CL:0002363
name: keratocyte
def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate." [GOC:tfm, ISBN:9780702029585]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
synonym: "corneal fibroblast" EXACT []
synonym: "corneal keratocyte" EXACT []
is_a: CL:0000005 ! fibroblast neural crest derived
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001777 ! substantia propria of cornea
relationship: part_of UBERON:0001777 ! substantia propria of cornea
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-22T01:57:40Z

[Term]
id: CL:0002368
name: respiratory epithelial cell
def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm]
subset: cellxgene_subset
synonym: "airway epithelial cell" EXACT []
xref: BTO:0004533
is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell
intersection_of: CL:0002076 ! endo-epithelial cell
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-23T04:38:49Z

[Term]
id: CL:0002372
name: myotube
def: "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." [GOC:dos, GOC:tfm, ISBN:0323052908, PMID:22274696]
synonym: "myotubule" EXACT []
synonym: "single cell sarcomere" EXACT []
xref: FBbt:00005812
is_a: CL:0000228 ! multinucleate cell
is_a: CL:0000737 ! striated muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_characteristic PATO:0001908 ! multinucleate
intersection_of: has_characteristic PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
relationship: has_characteristic PATO:0002478 ! transversely striated
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-09-24T01:13:01Z

[Term]
id: CL:0002421
name: nucleated reticulocyte
def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052]
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
is_a: CL:0002242 ! nucleate cell
intersection_of: CL:0000558 ! reticulocyte
intersection_of: has_characteristic PATO:0002505 ! nucleated
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-10-15T09:24:05Z

[Term]
id: CL:0002422
name: enucleated reticulocyte
def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464]
subset: cellxgene_subset
xref: CALOHA:TS-0864
xref: FMA:66785
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000558 {is_inferred="true"} ! reticulocyte
intersection_of: CL:0000558 ! reticulocyte
intersection_of: has_characteristic PATO:0001405 ! anucleate
intersection_of: has_part GO:0005840 ! ribosome
relationship: has_part GO:0005840 ! ribosome
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-10-15T09:24:08Z

[Term]
id: CL:0002494
name: cardiocyte
def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm]
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.
synonym: "heart cell" EXACT []
xref: BTO:0001539
xref: CALOHA:TS-0115
xref: FMA:83808
xref: FMA:84791
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0007100 ! primary circulatory organ
relationship: part_of UBERON:0007100 ! primary circulatory organ
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-12-07T09:37:22Z

[Term]
id: CL:0002503
name: adventitial cell
def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0002441
xref: FMA:84639
is_a: CL:0000630 ! supporting cell
is_a: CL:0002320 ! connective tissue cell
intersection_of: CL:0002320 ! connective tissue cell
intersection_of: part_of UBERON:0005742 ! adventitia
relationship: part_of UBERON:0005742 ! adventitia
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-12-07T04:03:56Z

[Term]
id: CL:0002504
name: enteric smooth muscle cell
def: "A smooth muscle cell of the intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "intestinal smooth muscle cell" EXACT []
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0000160 ! intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-01-17T03:39:38Z

[Term]
id: CL:0002518
name: kidney epithelial cell
def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ]
subset: cellxgene_subset
xref: KUPO:0001019
is_a: CL:0000066 ! epithelial cell
is_a: CL:1000497 {is_inferred="true"} ! kidney cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002113 ! kidney
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-08T10:46:34Z

[Term]
id: CL:0002521
name: subcutaneous adipocyte
def: "An adipocyte that is part of subcutaneous adipose tissue." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "subcutaneous fat cell" EXACT []
is_a: CL:0000136 {is_inferred="true"} ! adipocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000136 ! adipocyte
intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue
relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-21T02:51:22Z

[Term]
id: CL:0002538
name: intrahepatic cholangiocyte
def: "An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes." [GOC:tfm, PMID:23720296]
subset: cellxgene_subset
synonym: "small bile duct cholangiocyte" EXACT [PMID:23720296]
is_a: CL:1000488 {is_inferred="true"} ! cholangiocyte
intersection_of: CL:1000488 ! cholangiocyte
intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T01:20:20Z

[Term]
id: CL:0002539
name: aortic smooth muscle cell
def: "A smooth muscle cell of the aorta." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0004577
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue
relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T01:42:12Z

[Term]
id: CL:0002540
name: mesenchymal stem cell of the bone marrow
def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002371 ! bone marrow
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T01:47:47Z

[Term]
id: CL:0002541
name: chorionic membrane mesenchymal stem cell
def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm]
subset: human_reference_atlas
is_a: CL:0000134 ! mesenchymal stem cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003124 ! chorion membrane
relationship: part_of UBERON:0003124 ! chorion membrane
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T03:04:35Z

[Term]
id: CL:0002543
name: vein endothelial cell
def: "An endothelial cell that is part of the vein." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endothelial cell of vein" EXACT []
synonym: "venous endothelial cell" EXACT []
xref: FMA:62104
xref: KUPO:0001099
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0001638 ! vein
relationship: part_of UBERON:0001638 ! vein
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T03:48:11Z

[Term]
id: CL:0002546
name: embryonic blood vessel endothelial progenitor cell
def: "An endothelial progenitor cell that participates in angiogenesis during development." [GOC:tfm]
comment: See CL:0002619.
is_a: CL:0000222 ! mesodermal cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T04:20:39Z

[Term]
id: CL:0002547
name: fibroblast of the aortic adventitia
def: "A fibroblast of the aortic adventitia." [GOC:tfm]
is_a: CL:1000306 {is_inferred="true"} ! fibroblast of tunica adventitia of artery
intersection_of: CL:1000306 ! fibroblast of tunica adventitia of artery
intersection_of: part_of UBERON:0004664 ! aorta tunica adventitia
relationship: part_of UBERON:0004664 ! aorta tunica adventitia
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T04:43:41Z

[Term]
id: CL:0002548
name: fibroblast of cardiac tissue
def: "A fibroblast that is part of the heart." [GOC:tfm]
subset: cellxgene_subset
synonym: "cardiac fibroblast" EXACT []
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002494 {is_inferred="true"} ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T04:57:44Z

[Term]
id: CL:0002551
name: fibroblast of dermis
is_a: CL:0002620 {is_inferred="true"} ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T05:05:33Z

[Term]
id: CL:0002553
name: fibroblast of lung
def: "A fibroblast that is part of lung." [GOC:tfm]
subset: cellxgene_subset
xref: BTO:0000764
xref: CALOHA:TS-0575
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T05:11:03Z

[Term]
id: CL:0002557
name: fibroblast of pulmonary artery
def: "A fibroblast of pulmonary artery." [GOC:tfm]
subset: human_reference_atlas
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-02-28T05:22:27Z

[Term]
id: CL:0002563
name: intestinal epithelial cell
def: "An epithelial cell of the intestine." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0001277 ! intestinal epithelium
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-01T05:18:31Z

[Term]
id: CL:0002569
name: mesenchymal stem cell of umbilical cord
def: "A mesenchymal stem cell of the umbilical cord." [GOC:tfm]
is_a: CL:0000134 ! mesenchymal stem cell
is_a: CL:0000349 ! extraembryonic cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0003422 ! mesenchyme of umbilical cord
relationship: part_of UBERON:0003422 ! mesenchyme of umbilical cord
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-01T09:55:12Z

[Term]
id: CL:0002570
name: mesenchymal stem cell of adipose tissue
def: "A mesenchymal stem cell of adipose tissue." [GOC:tfm]
subset: cellxgene_subset
synonym: "mesenchymal stem cell of adipose" EXACT []
is_a: CL:0000134 ! mesenchymal stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: part_of UBERON:0001013 ! adipose tissue
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-01T09:57:17Z

[Term]
id: CL:0002571
name: hepatic mesenchymal stem cell
def: "A mesenchymal stem cell of liver." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0002195 ! hepatic stem cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002107 ! liver
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-01T09:58:51Z

[Term]
id: CL:0002572
name: vertebral mesenchymal stem cell
def: "A mesenchymal stem cell of the vertebrae." [GOC:tfm]
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0001035 ! bone cell
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0002412 ! vertebra
relationship: part_of UBERON:0002412 ! vertebra
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-01T10:40:27Z

[Term]
id: CL:0002574
name: stromal cell of pancreas
def: "A stromal cell of the pancreas." [GOC:tfm]
subset: human_reference_atlas
is_a: CL:0000499 {is_inferred="true"} ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001264 ! pancreas
relationship: part_of UBERON:0001264 ! pancreas
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-02T02:40:41Z

[Term]
id: CL:0002577
name: placental epithelial cell
def: "An epithelial cell of the placenta." [GOC:tfm]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-02T03:21:30Z

[Term]
id: CL:0002584
name: renal cortical epithelial cell
def: "An epithelial cell of the kidney cortex." [GOC:tfm]
xref: KUPO:0001016
is_a: CL:0002518 {is_inferred="true"} ! kidney epithelial cell
is_a: CL:0002681 {is_inferred="true"} ! kidney cortical cell
intersection_of: CL:0002518 ! kidney epithelial cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney

[Term]
id: CL:0002585
name: retinal blood vessel endothelial cell
def: "A blood vessel endothelial cell that is part of the retina." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
subset: human_reference_atlas
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
is_a: CL:0009004 ! retinal cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000966 ! retina
relationship: part_of UBERON:0000966 ! retina
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T03:28:27Z

[Term]
id: CL:0002589
name: smooth muscle cell of the brachiocephalic vasculature
def: "A smooth muscle cell of the bachiocephalic vasculature." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001529 ! brachiocephalic artery
relationship: part_of UBERON:0001529 ! brachiocephalic artery
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:00:58Z

[Term]
id: CL:0002590
name: smooth muscle cell of the brain vasculature
def: "A vascular associated smooth muscle cell of the brain vasculature." [GOC:tfm]
is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell
is_a: CL:0002319 ! neural cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:01:20Z

[Term]
id: CL:0002591
name: smooth muscle cell of the pulmonary artery
def: "A smooth muscle of the pulmonary artery." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0003336
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0002012 ! pulmonary artery
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:01:28Z

[Term]
id: CL:0002594
name: smooth muscle cell of the umbilical artery
def: "A smooth muscle cell of the umbilical artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: part_of UBERON:0001310 ! umbilical artery
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:01:48Z

[Term]
id: CL:0002595
name: smooth muscle cell of the subclavian artery
def: "A smooth muscle cell of the subclavian artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0001533 ! subclavian artery
relationship: part_of UBERON:0001533 ! subclavian artery
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:01:52Z

[Term]
id: CL:0002596
name: smooth muscle cell of the carotid artery
def: "Smooth muscle cell of the carotid artery." [GOC:tfm]
is_a: CL:0019018 ! blood vessel smooth muscle cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0005396 ! carotid artery segment
relationship: part_of UBERON:0005396 ! carotid artery segment
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:01:56Z

[Term]
id: CL:0002597
name: smooth muscle cell of bladder
def: "A smooth muscle cell of the bladder." [GC:tfm]
subset: human_reference_atlas
xref: KUPO:0001122
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1001319 ! bladder cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:43:24Z

[Term]
id: CL:0002599
name: smooth muscle cell of the esophagus
def: "A smooth muscle cell of the esophagus." [GOC:tfm]
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:48:17Z

[Term]
id: CL:0002601
name: uterine smooth muscle cell
def: "A smooth muscle cell of the uterus." [GOC:tfm]
subset: cellxgene_subset
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T05:53:28Z

[Term]
id: CL:0002610
name: raphe nuclei neuron
def: "A neuron of the raphe nuclei." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: has_soma_location UBERON:0004684 ! raphe nuclei
relationship: has_soma_location UBERON:0004684 ! raphe nuclei
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T07:42:06Z

[Term]
id: CL:0002612
name: neuron of the ventral spinal cord
def: "A neuron of the ventral spinal cord." [GOC:tfm]
is_a: CL:0000117 {is_inferred="true"} ! CNS neuron (sensu Vertebrata)
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000117 ! CNS neuron (sensu Vertebrata)
intersection_of: has_soma_location UBERON:0002257 ! ventral horn of spinal cord
relationship: has_soma_location UBERON:0002257 ! ventral horn of spinal cord
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-06T07:46:03Z

[Term]
id: CL:0002620
name: skin fibroblast
def: "A fibroblast of skin." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: BTO:0001255
xref: CALOHA:TS-0935
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: part_of UBERON:0002097 ! skin of body
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-14T12:31:49Z

[Term]
id: CL:0002625
name: seminiferous tubule epithelial cell
def: "A cell of the seminiferous tubule epithelium." [GOC:tfm]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000077 {is_inferred="true"} ! mesothelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of UBERON:0004813 ! seminiferous tubule epithelium
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-03-15T11:59:23Z

[Term]
id: CL:0002632
name: epithelial cell of lower respiratory tract
subset: cellxgene_subset
is_a: CL:0002368 {is_inferred="true"} ! respiratory epithelial cell
intersection_of: CL:0002368 ! respiratory epithelial cell
intersection_of: part_of UBERON:0001558 ! lower respiratory tract
relationship: part_of UBERON:0001558 ! lower respiratory tract
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-06-21T12:29:31Z

[Term]
id: CL:0002656
name: glandular cell of endometrium
def: "A glandular epithelial cell of the endometrium." [GOC:tfm]
xref: FMA:86489
is_a: CL:1001591 ! oviduct secretory cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001295 ! endometrium
relationship: part_of UBERON:0001295 ! endometrium
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-08T03:54:08Z

[Term]
id: CL:0002657
name: glandular cell of esophagus
def: "A glandular epithelial cell of the esophagus." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:86548
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002252 {is_inferred="true"} ! epithelial cell of esophagus
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001043 ! esophagus
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-08T03:55:57Z

[Term]
id: CL:0002658
name: glandular cell of the large intestine
def: "A glandular epithelial cell of the large intestine." [GOC:tfm]
xref: FMA:87194
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000059 ! large intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-08T04:03:01Z

[Term]
id: CL:0002659
name: glandular cell of stomach
def: "A glandular epithelial cell that is part of the stomach." [GOC:tfm]
xref: CALOHA:TS-1284
xref: FMA:86554
is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell
is_a: CL:0002178 ! epithelial cell of stomach
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000945 ! stomach
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-11T01:20:35Z

[Term]
id: CL:0002663
name: myocardial endocrine cell of atrium
def: "A myocardial endocrine cell that is part of the atrium." [GOC:tfm]
xref: FMA:83389
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-11T02:45:39Z

[Term]
id: CL:0002664
name: cardioblast
def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164]
comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell.
synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164]
synonym: "CPC" RELATED OMO:0003000 [PMID:19745164]
is_a: CL:0000048 ! multi fate stem cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-07-11T03:15:38Z

[Term]
id: CL:0002672
name: retinal progenitor cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186]
is_a: CL:0000048 ! multi fate stem cell
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from CL:0000133 ! neurectodermal cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-08-16T02:38:01Z

[Term]
id: CL:0002676
name: neural crest derived neuroblast
def: "A neuroblast derived from a neural crest cell." [GOC:tfm, PMID:17407019]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
is_a: CL:0011026 ! progenitor cell
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: develops_from CL:0000333 ! migratory neural crest cell
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-08-22T09:24:15Z

[Term]
id: CL:0002680
name: PP cell of intestine
def: "A PP cell found in intestine." [GOC:tfm, PMID:2420136, PMID:728970]
is_a: CL:0000696 {is_inferred="true"} ! PP cell
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000696 ! PP cell
intersection_of: part_of UBERON:0000160 ! intestine
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2011-09-27T11:59:01Z

[Term]
id: CL:0002681
name: kidney cortical cell
def: "A cell that is part of a cortex of kidney." []
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001225 ! cortex of kidney
relationship: part_of UBERON:0001225 ! cortex of kidney
property_value: term:contributor https://orcid.org/0000-0002-0956-8634
creation_date: 2011-10-25T03:49:41Z

[Term]
id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: has_soma_location UBERON:0002240 ! spinal cord
relationship: has_soma_location UBERON:0002240 ! spinal cord

[Term]
id: CL:0005009
name: renal principal cell
def: "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system." [CL:CVS]
subset: cellxgene_subset
is_a: CL:0000075 ! columnar/cuboidal epithelial cell
is_a: CL:0002518 ! kidney epithelial cell

[Term]
id: CL:0005024
name: somatomotor neuron
def: "A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic." [ZFIN:CVS]
synonym: "somatic motor neuron" EXACT []
is_a: CL:0000100 ! motor neuron
is_a: CL:0000108 ! cholinergic neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: synapsed_to CL:0008002 ! skeletal muscle fiber
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of RO:0002577 ! system
relationship: synapsed_to CL:0008002 ! skeletal muscle fiber

[Term]
id: CL:0005026
name: hepatoblast
def: "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation." [GOC:CVS, https://orcid.org/0000-0003-1940-6740, PMID:18356246, PMID:20483998, PMID:26798363]
subset: cellxgene_subset
is_a: CL:0000048 ! multi fate stem cell
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/800" xsd:string

[Term]
id: CL:0007001
name: skeletogenic cell
def: "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized)." [GO_REF:0000034]
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)
synonym: "scleroblast" EXACT [GO_REF:0000034]
is_a: CL:0000000 ! cell
property_value: term:contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-15T02:51:27Z

[Term]
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
is_a: CL:0011012 ! neural crest cell
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: develops_from CL:0000133 ! neurectodermal cell
relationship: part_of UBERON:0002342 ! neural crest
property_value: term:contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-27T08:27:35Z

[Term]
id: CL:0007009
name: prechondroblast
def: "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." [GO_REF:0000034]
is_a: CL:0000055 ! non-terminally differentiated cell
property_value: term:contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2012-06-27T10:44:01Z

[Term]
id: CL:0008000
name: non-striated muscle cell
def: "Any muscle cell in which the fibers are not organised into sarcomeres." [GOC:DOS]
is_a: CL:0000187 ! muscle cell

[Term]
id: CL:0008001
name: hematopoietic precursor cell
def: "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." [GOC:dos]
subset: cellxgene_subset
is_a: CL:0000988 ! hematopoietic cell

[Term]
id: CL:0008002
name: skeletal muscle fiber
def: "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908]
subset: cellxgene_subset
xref: MESH:D018485
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0002372 ! myotube
intersection_of: CL:0000187 ! muscle cell
intersection_of: has_characteristic PATO:0001908 ! multinucleate
intersection_of: has_characteristic PATO:0002478 ! transversely striated
intersection_of: has_part GO:0030017 ! sarcomere
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
relationship: develops_from CL:0000515 ! skeletal muscle myoblast

[Term]
id: CL:0008007
name: visceral muscle cell
def: "A muscle cell that is part of some visceral muscle." [GOC:dos]
xref: FBbt:00005070
is_a: CL:0000187 ! muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:8600004 ! visceral muscle tissue
relationship: part_of UBERON:8600004 ! visceral muscle tissue

[Term]
id: CL:0008008
name: striated visceral muscle cell
def: "A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods." [GOC:dos]
is_a: CL:0000737 ! striated muscle cell
is_a: CL:0008007 ! visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: has_characteristic PATO:0001410 {all_some="true"} ! striated

[Term]
id: CL:0008009
name: transversely striated visceral muscle cell
def: "A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods." [GOC:dos]
is_a: CL:0008008 ! striated visceral muscle cell
intersection_of: CL:0008007 ! visceral muscle cell
intersection_of: has_characteristic PATO:0002478 {all_some="true"} ! transversely striated
relationship: has_characteristic PATO:0002478 ! transversely striated

[Term]
id: CL:0008017
name: adult skeletal muscle myoblast
def: "A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers." [PMID:23303905]
comment: The vast majority of these cells develop from skeletal muscle satellite cells, although there are some reports of other origins.
synonym: "myogenic precursor cell" BROAD [PMID:23303905]
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:0000515 ! skeletal muscle myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0008002 ! skeletal muscle fiber
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: CL:0008019
name: mesenchymal cell
def: "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." []
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "mesenchyme cell" EXACT []
is_a: CL:0000219 ! motile cell
is_a: CL:0000255 ! eukaryotic cell
relationship: capable_of GO:0016477 ! cell migration
relationship: part_of UBERON:0003104 ! mesenchyme
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0008022
name: endocardial cushion cell
def: "A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves." [PMID:18816864]
is_a: CL:0000569 ! cardiac mesenchymal cell
is_a: CL:0002494 ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000569 ! cardiac mesenchymal cell
intersection_of: part_of UBERON:0002062 ! endocardial cushion
relationship: part_of UBERON:0002062 ! endocardial cushion

[Term]
id: CL:0008024
name: pancreatic endocrine cell
def: "An endocrine cell that is part of the pancreas." [GOC:dos]
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000083 ! epithelial cell of pancreas
is_a: CL:0000164 ! enteroendocrine cell
intersection_of: CL:0000163 ! endocrine cell
intersection_of: part_of UBERON:0001264 ! pancreas
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0008025
name: noradrenergic neuron
def: "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter." [GOC:dos]
is_a: CL:0000459 ! noradrenergic cell
is_a: CL:4033050 ! catecholaminergic neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission
relationship: capable_of GO:0061533 ! norepinephrine secretion, neurotransmission

[Term]
id: CL:0008028
name: visual system neuron
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of_part_of GO:0007601 ! visual perception
relationship: capable_of_part_of GO:0007601 ! visual perception
property_value: term:contributor https://orcid.org/0000-0002-7073-9172
creation_date: 2017-07-09T19:12:36Z

[Term]
id: CL:0008034
name: mural cell
def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." [Wiki:Mural_cell&oldid=930603194]
subset: added_for_HCA
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:4033054 ! perivascular cell
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0002-7073-9172
creation_date: 2020-02-29T17:33:55Z

[Term]
id: CL:0008035
name: microcirculation associated smooth muscle cell
is_a: CL:0000359 ! vascular associated smooth muscle cell
is_a: CL:0008034 ! mural cell
intersection_of: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: part_of UBERON:0010523 ! microcirculatory vessel
relationship: part_of UBERON:0010523 ! microcirculatory vessel
property_value: term:contributor https://orcid.org/0000-0002-7073-9172
creation_date: 2020-02-29T17:37:00Z

[Term]
id: CL:0009000
name: sensory neuron of spinal nerve
def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr]
synonym: "spinal sensory neuron" EXACT []
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: has_soma_location UBERON:0001780 ! spinal nerve
relationship: has_soma_location UBERON:0001780 ! spinal nerve

[Term]
id: CL:0009001
name: compound eye retinal cell
def: "Any cell in the compound eye, a light sensing organ composed of ommatidia." []
xref: GOC:pr
xref: PMID:12021768
is_a: CL:0009004 ! retinal cell

[Term]
id: CL:0009004
name: retinal cell
def: "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:pr]
subset: general_cell_types_upper_slim
xref: PMID:10702418
is_a: CL:0002319 ! neural cell
intersection_of: CL:0002319 ! neural cell
intersection_of: part_of UBERON:0005388 ! photoreceptor array
relationship: part_of UBERON:0005388 ! photoreceptor array

[Term]
id: CL:0009006
name: enteroendocrine cell of small intestine
def: "An enteroendocrine cell that is located in the small intestine." [http://orcid.org/0000-0003-3440-1876]
subset: cellxgene_subset
subset: location_grouping
synonym: "small intestine enteroendocrine cell" EXACT []
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0002108 ! small intestine
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009018
name: lymphocyte of large intestine lamina propria
def: "A lymphocyte that resides in the lamina propria of the large intestine." [https://orcid.org/0000-0003-4183-8865]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: human_reference_atlas
subset: location_grouping
synonym: "lamina propria lymphocyte of large intestine" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009019
name: nephrogenic zone cell
def: "A kidney cortical cell that is part of the nephrogenic zone." [https://orcid.org/0000-0002-3163-0115, PMID:29449449]
subset: added_for_HCA
synonym: "cortical nephrogenic niche cell" EXACT []
synonym: "cortical nephrogenic zone cell" EXACT []
is_a: CL:0002681 ! kidney cortical cell
intersection_of: CL:0002681 ! kidney cortical cell
intersection_of: part_of UBERON:0009871 ! nephrogenic zone
relationship: part_of UBERON:0009871 ! nephrogenic zone
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009021
name: stromal cell of lamina propria of large intestine
def: "A stromal cell found in the lamina propria of the large intestine." [http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
relationship: part_of UBERON:0011189 ! lamina propria of large intestine
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009022
name: stromal cell of lamina propria of small intestine
def: "A stromal cell found in the lamina propria of the small intestine." [http://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
is_a: CL:0000499 ! stromal cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: part_of UBERON:0001238 ! lamina propria of small intestine
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009024
name: mesothelial cell of small intestine
def: "A mesothelial cell that is part of the small intestine." [http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002254 ! epithelial cell of small intestine
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009025
name: mesothelial cell of colon
def: "A mesothelial cell that is part of the colon." [http://orcid.org/0000-0003-3440-1876, http://orcid.org/0000-0003-4183-8865]
subset: location_grouping
synonym: "mesothelial cell of large intestine" BROAD []
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0011108 ! colon epithelial cell
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001155 ! colon
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009040
name: stromal cell of lamina propria of colon
def: "A stromal cell found in the lamina propria of the colon." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "stromal cell of colon lamina propria" EXACT []
is_a: CL:0009021 ! stromal cell of lamina propria of large intestine
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0007177 ! lamina propria of mucosa of colon
relationship: part_of UBERON:0007177 ! lamina propria of mucosa of colon
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009042
name: enteroendocrine cell of colon
def: "An enteroendocrine cell that is located in the colon." [http://orcid.org/0000-0003-3440-1876]
subset: cellxgene_subset
subset: location_grouping
synonym: "colon enteroendocrine cell" EXACT []
is_a: CL:1001516 ! intestinal enteroendocrine cell
is_a: CL:1001588 ! colon glandular cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001155 ! colon
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009044
name: lymphocyte of small intestine lamina propria
def: "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response." [https://orcid.org/0000-0003-4183-8865, PMID:26551552]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
synonym: "gastrointestinal tract (lamina propria) lymphocyte of small intestine" EXACT []
synonym: "gastrointestinal tract small intestine (lamina propria) leukocyte" BROAD []
synonym: "lamina propria lymphocyte of small intestine" EXACT []
synonym: "small intestine lamina propria leukocyte" BROAD []
synonym: "small intestine lamina propria leukocyte (LPL)" BROAD []
synonym: "small intestine lamina propria lymphocyte" EXACT []
is_a: CL:0000542 ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine
relationship: part_of UBERON:0001238 ! lamina propria of small intestine
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009051
name: T cell of anorectum
def: "A T cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
comment: This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you.
subset: location_grouping
is_a: CL:0000084 ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: part_of UBERON:8410050 ! anorectum
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009052
name: smooth muscle cell of anorectum
def: "A smooth muscle cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum smooth muscle cell" EXACT []
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: part_of UBERON:8410050 ! anorectum
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009053
name: stromal cell of anorectum lamina propria
def: "A stromal cell found in the lamina propria of the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
is_a: CL:0009021 ! stromal cell of lamina propria of large intestine
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0011189 ! lamina propria of large intestine
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: part_of UBERON:8410050 ! anorectum
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009063
name: enteroendocrine cell of anorectum
def: "An enteroendocrine cell that is located in the anorectum." [http://orcid.org/0000-0003-3440-1876]
subset: location_grouping
synonym: "anorectum enteroendocrine cell" EXACT []
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:1001516 ! intestinal enteroendocrine cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:8410050 ! anorectum
relationship: part_of UBERON:8410050 ! anorectum
property_value: term:contributor https://orcid.org/0000-0002-2825-0621

[Term]
id: CL:0009084
name: epithelial cell of endometrial gland
def: "An epithelial cell that is part of an endometrial gland." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: human_reference_atlas
subset: location_grouping
synonym: "endometrial glandular epithelial cell" EXACT []
xref: EFO:0010710
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002451 ! endometrial gland
relationship: part_of UBERON:0002451 ! endometrial gland
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2021-11-30T16:13:30Z" xsd:dateTime

[Term]
id: CL:0009092
name: endothelial cell of placenta
def: "An endothelial cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
synonym: "placental endothelial cell" EXACT []
xref: EFO:0010708
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002577 ! placental epithelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001987 ! placenta
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2021-12-13T13:53:01Z" xsd:dateTime

[Term]
id: CL:0009093
name: smooth muscle cell of placenta
def: "A smooth muscle cell that is part of a placenta." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: location_grouping
synonym: "placental smooth muscle cell" EXACT []
xref: EFO:0010709
is_a: CL:0000192 ! smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2021-12-13T13:56:42Z" xsd:dateTime

[Term]
id: CL:0009094
name: endothelial cell of hepatic portal vein
def: "An endothelial cell that is part of a hepatic portal vein." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865, PMID:30348985]
subset: location_grouping
synonym: "portal endothelial cell" BROAD []
xref: EFO:0010704
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001639 ! hepatic portal vein
relationship: part_of UBERON:0001639 ! hepatic portal vein
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2021-12-13T14:01:05Z" xsd:dateTime

[Term]
id: CL:0009095
name: endothelial cell of uterus
def: "An endothelial cell that is part of a uterus." [https://orcid.org/0000-0003-3440-1876, https://orcid.org/0000-0003-4183-8865]
subset: cellxgene_subset
subset: location_grouping
synonym: "uterine endothelial cell" EXACT []
xref: EFO:0010711
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2021-12-13T14:39:25Z" xsd:dateTime

[Term]
id: CL:0009097
name: embryonic skeletal muscle fiber
def: "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development." [http://orcid.org/0000-0003-2034-601X, PMID:32094117, PMID:7196501]
is_a: CL:0008002 ! skeletal muscle fiber
intersection_of: CL:0008002 ! skeletal muscle fiber
intersection_of: existence_starts_and_ends_during UBERON:0000068 ! embryo stage
relationship: existence_starts_and_ends_during UBERON:0000068 ! embryo stage
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2022-02-21T15:39:10Z" xsd:dateTime

[Term]
id: CL:0009100
name: hepatic portal fibroblast
def: "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen." [https://orcid.org/0000-0001-7655-4833, PMID:20209607, PMID:24814904]
subset: human_reference_atlas
synonym: "portal fibroblast" BROAD []
is_a: CL:0000057 ! fibroblast
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001279 ! portal triad
relationship: part_of UBERON:0001279 ! portal triad
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0002-2825-0621
property_value: term:date "2022-03-17T12:00:44Z" xsd:dateTime

[Term]
id: CL:0010001
name: stromal cell of bone marrow
def: "A stromal cell that is part_of a bone marrow." []
synonym: "bone marrow stromal cell" EXACT []
is_a: CL:0000499 ! stromal cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000499 ! stromal cell
intersection_of: part_of UBERON:0002371 ! bone marrow
property_value: term:contributor https://orcid.org/0000-0002-6601-2165

[Term]
id: CL:0010002
name: epithelial cell of umbilical artery
def: "An epithelial cell that is part_of a umbilical artery." []
synonym: "umbilical artery epithelial cell" EXACT []
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001310 ! umbilical artery
relationship: part_of UBERON:0001310 ! umbilical artery
property_value: term:contributor https://orcid.org/0000-0002-6601-2165

[Term]
id: CL:0010004
name: mononuclear cell of bone marrow
def: "A mononuclear cell that is part_of a bone marrow." []
synonym: "bone marrow mononuclear cell" EXACT []
is_a: CL:0000842 ! mononuclear cell
is_a: CL:1001610 ! bone marrow hematopoietic cell
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0002371 ! bone marrow
property_value: term:contributor https://orcid.org/0000-0002-6601-2165

[Term]
id: CL:0010006
name: cardiac blood vessel endothelial cell
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: CL:0010008 ! cardiac endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0000948 ! heart

[Term]
id: CL:0010007
name: His-Purkinje system cell
is_a: CL:0002494 ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0004146 ! His-Purkinje system
relationship: part_of UBERON:0004146 ! His-Purkinje system

[Term]
id: CL:0010008
name: cardiac endothelial cell
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:0010009
name: camera-type eye photoreceptor cell
synonym: "camera type eye photoreceptor cell" EXACT []
is_a: CL:0000287 ! eye photoreceptor cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000019 ! camera-type eye
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0000019 ! camera-type eye

[Term]
id: CL:0010017
name: zygote
def: "A zygote in a plant or an animal." []
xref: MESH:D015053
is_a: CL:0000000 ! cell
relationship: seeAlso https://github.com/obophenotype/cell-ontology/issues/786

[Term]
id: CL:0010020
name: cardiac glial cell
is_a: CL:0000125 ! glial cell
is_a: CL:0002494 ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000125 ! glial cell
intersection_of: part_of UBERON:0000948 ! heart
relationship: part_of UBERON:0000948 ! heart

[Term]
id: CL:0010021
name: cardiac myoblast
xref: MESH:D032386
is_a: CL:0000056 ! myoblast
intersection_of: CL:0000056 ! myoblast
intersection_of: develops_into CL:0000746 ! cardiac muscle cell
relationship: develops_into CL:0000746 ! cardiac muscle cell

[Term]
id: CL:0010022
name: cardiac neuron
def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764]
comment: This term is used in 3 GO terms that were created as part of the heart development focus project.
subset: cellxgene_subset
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: has_soma_location UBERON:0000948 ! heart
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_soma_location UBERON:0000948 ! heart
property_value: seeAlso "https://github.com/obophenotype/cell-ontology/pull/1488" xsd:string

[Term]
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv]
is_a: CL:0000100 {is_inferred="true"} ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: has_soma_location UBERON:0002240 ! spinal cord
relationship: has_soma_location UBERON:0002240 ! spinal cord

[Term]
id: CL:0011007
name: paraxial cell
def: "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." [GOC:NV, PMID:11687492]
synonym: "paraxial mesoderm cell" EXACT []
synonym: "presomitic mesoderm cell" NARROW []
synonym: "somitic mesoderm cell" EXACT []
is_a: CL:0000222 ! mesodermal cell
intersection_of: CL:0000222 ! mesodermal cell
intersection_of: part_of UBERON:0003059 ! presomitic mesoderm
relationship: part_of UBERON:0003059 ! presomitic mesoderm

[Term]
id: CL:0011012
name: neural crest cell
def: "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." [https://orcid.org/0000-0001-5208-3432, https://orcid.org/0000-0002-9900-7880]
subset: cellxgene_subset
is_a: CL:0000048 ! multi fate stem cell
is_a: CL:0002321 ! embryonic cell (metazoa)

[Term]
id: CL:0011013
name: motile sperm cell
def: "A sperm cell that is cabaple of motion (motility)." [PMID:30612620]
is_a: CL:0000019 ! sperm
is_a: CL:0000219 ! motile cell
intersection_of: CL:0000019 ! sperm
intersection_of: capable_of GO:0097722 ! sperm motility
relationship: capable_of GO:0097722 ! sperm motility
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011016
name: flagellated sperm cell
def: "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." [https://www.lexico.com/en/definition/flagellum, PMID:30612620]
is_a: CL:0011013 ! motile sperm cell
intersection_of: CL:0011013 ! motile sperm cell
intersection_of: capable_of GO:0030317 ! flagellated sperm motility
relationship: capable_of GO:0030317 ! flagellated sperm motility
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011019
name: mesothelial cell of epicardium
def: "A mesothelial cell that is part of the epicardium." []
subset: cellxgene_subset
is_a: CL:0000077 ! mesothelial cell
is_a: CL:0002494 ! cardiocyte
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002348 ! epicardium
relationship: part_of UBERON:0002348 ! epicardium
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011021
name: fibroblast of upper back skin
def: "A fibroblast that is part of upper back skin." []
is_a: CL:0011022 ! fibroblast of skin of back
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0009015 ! upper back skin
relationship: part_of UBERON:0009015 ! upper back skin
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011022
name: fibroblast of skin of back
def: "A fibroblast that is part of skin of back." []
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001068 ! skin of back
relationship: part_of UBERON:0001068 ! skin of back
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3]
subset: cellxgene_subset
is_a: CL:0000255 ! eukaryotic cell
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_from CL:0000034 ! stem cell
relationship: develops_from CL:0000034 ! stem cell
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011027
name: skeletal muscle fibroblast
def: "Any fibroblast that is part of skeletal muscle tissue." [https://orcid.org/0000-0001-6164-0667, PMID:28369879]
subset: cellxgene_subset
synonym: "skeleton muscle fibroblast" EXACT []
is_a: CL:0000188 ! cell of skeletal muscle
is_a: CL:1001609 ! muscle fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011030
name: dermal microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of the dermis." [BTO:0004574, CL:patterns/cellPartOfAnatomicalEntity]
synonym: "dermal microvascular endothelium cell" EXACT []
synonym: "DMEC cell" EXACT []
is_a: CL:2000008 ! microvascular endothelial cell
is_a: CL:2000010 ! dermis blood vessel endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0002067 ! dermis
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: CL:0011101
name: chorionic trophoblast cell
def: "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:NV]
subset: cellxgene_subset
is_a: CL:0000351 ! trophoblast cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000351 ! trophoblast cell
intersection_of: part_of UBERON:0003124 ! chorion membrane
relationship: part_of UBERON:0003124 ! chorion membrane

[Term]
id: CL:0011108
name: colon epithelial cell
def: "Epithelial cell that is part of the colon epithelium." [GOC:NV]
subset: cellxgene_subset
synonym: "colonic epithelial cell" EXACT []
is_a: CL:0002253 ! epithelial cell of large intestine
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0000397 ! colonic epithelium

[Term]
id: CL:0011115
name: precursor cell
def: "A cell that, by division or terminal differentiation, can give rise to other cell types." [GOC:dos]
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.
subset: cellxgene_subset
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: capable_of GO:0030154 ! cell differentiation
relationship: capable_of GO:0030154 ! cell differentiation

[Term]
id: CL:0017500
name: neutrophillic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." [GOC:add]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: has_characteristic PATO:0070046 ! neutrophillic
relationship: has_characteristic PATO:0070046 ! neutrophillic
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2010-05-25T01:36:34Z

[Term]
id: CL:0017502
name: acidophilic cytoplasm
def: "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain." [GOC:add]
synonym: "eosinophilic" NARROW []
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: has_characteristic PATO:0002418 ! acidophilic
relationship: has_characteristic PATO:0002418 ! acidophilic
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2009-12-22T04:23:25Z

[Term]
id: CL:0017503
name: basophilic cytoplasm
def: "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: has_characteristic PATO:0002094 ! basophilic
relationship: has_characteristic PATO:0002094 ! basophilic
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2009-12-22T04:24:54Z

[Term]
id: CL:0017504
name: polychromatophilic cytoplasm
def: "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions." [GOC:tfm]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: has_characteristic PATO:0070047 ! polychromatophilic
relationship: has_characteristic PATO:0070047 ! polychromatophilic
property_value: term:contributor https://orcid.org/0000-0003-1980-3228
creation_date: 2009-12-28T04:25:23Z

[Term]
id: CL:0019018
name: blood vessel smooth muscle cell
def: "A smooth muscle cell that is part of any blood vessel." [PMID:9108778]
subset: human_reference_atlas
synonym: "smooth muscle cell of blood vessel" EXACT []
is_a: CL:0000359 ! vascular associated smooth muscle cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001981 ! blood vessel
relationship: part_of UBERON:0001981 ! blood vessel
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0003-2034-601X
property_value: term:date "2020-07-21T12:42:48Z" xsd:dateTime

[Term]
id: CL:0019020
name: extrahepatic cholangiocyte
def: "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes." [PMID:23720296]
synonym: "large bile duct cholangiocyte" EXACT [PMID:23720296]
is_a: CL:1000488 ! cholangiocyte
intersection_of: CL:1000488 ! cholangiocyte
intersection_of: part_of UBERON:0004822 ! extrahepatic bile duct epithelium
relationship: part_of UBERON:0004822 ! extrahepatic bile duct epithelium
property_value: term:contributor https://orcid.org/0000-0003-2034-601X
property_value: term:date "2020-09-03T12:24:24Z" xsd:dateTime

[Term]
id: CL:0019021
name: endothelial cell of periportal hepatic sinusoid
def: "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid." [PMID:27423426]
subset: cellxgene_subset
synonym: "periportal hepatic sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "periportal LSEC" EXACT [PMID:28287163]
xref: EFO:0010705
is_a: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: adjacent_to UBERON:0001279 ! portal triad
relationship: adjacent_to UBERON:0001279 ! portal triad
property_value: term:contributor https://orcid.org/0000-0003-2034-601X
property_value: term:date "2020-09-09T13:56:47Z" xsd:dateTime

[Term]
id: CL:0019022
name: endothelial cell of pericentral hepatic sinusoid
def: "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid." [PMID:27423426]
subset: cellxgene_subset
synonym: "central venous hepatic sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "pericentral LSEC" EXACT [PMID:28287163]
xref: EFO:0010706
is_a: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: CL:1000398 ! endothelial cell of hepatic sinusoid
intersection_of: adjacent_to UBERON:0006841 ! central vein of liver
relationship: adjacent_to UBERON:0006841 ! central vein of liver
property_value: term:contributor https://orcid.org/0000-0003-2034-601X
property_value: term:date "2020-09-10T12:38:29Z" xsd:dateTime

[Term]
id: CL:1000090
name: pronephric nephron tubule epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005310 ! pronephric nephron tubule
relationship: part_of UBERON:0005310 ! pronephric nephron tubule

[Term]
id: CL:1000123
name: metanephric nephron tubule epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0005146 ! metanephric nephron tubule
relationship: part_of UBERON:0005146 ! metanephric nephron tubule

[Term]
id: CL:1000222
name: stomach neuroendocrine cell
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0002659 ! glandular cell of stomach
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0000945 ! stomach
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)

[Term]
id: CL:1000223
name: lung neuroendocrine cell
def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "PNEC" RELATED OMO:0003000 [PMID:33355253]
synonym: "pulmonary neuroendocrine cell" EXACT [PMID:33355253]
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0000098 ! sensory epithelial cell
is_a: CL:0000165 ! neuroendocrine cell
is_a: CL:0000206 ! chemoreceptor cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:1000272 ! lung secretory cell
intersection_of: CL:0000165 ! neuroendocrine cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: capable_of GO:0070483 ! detection of hypoxia
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_part GO:0031045 ! dense core granule
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000271
name: lung ciliated cell
subset: cellxgene_subset
subset: human_reference_atlas
is_a: CL:4030034 ! respiratory ciliated cell
intersection_of: CL:0000064 ! ciliated cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000272
name: lung secretory cell
subset: cellxgene_subset
is_a: CL:0000151 ! secretory cell
is_a: CL:0000255 ! eukaryotic cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000151 ! secretory cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: CL:1000274
name: trophectodermal cell
synonym: "trophectoderm cell" EXACT []
is_a: CL:0000349 ! extraembryonic cell

[Term]
id: CL:1000275
name: smooth muscle cell of small intestine
def: "A smooth muscle cell that is part of the small intestine." [GOC:tfm]
subset: cellxgene_subset
synonym: "non-striated muscle fiber of small intestine" EXACT [FMA:15050]
xref: FMA:15050
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0002108 ! small intestine

[Term]
id: CL:1000276
name: smooth muscle fiber of duodenum
def: "A smooth muscle cell that is part of the duodenum." [GOC:tfm]
synonym: "non-striated muscle fiber of duodenum" EXACT [FMA:15058]
xref: FMA:15058
is_a: CL:1000275 {is_inferred="true"} ! smooth muscle cell of small intestine
intersection_of: CL:1000275 ! smooth muscle cell of small intestine
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum

[Term]
id: CL:1000279
name: smooth muscle cell of large intestine
def: "A smooth muscle cell that is part of the large intestine." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "non-striated muscle fiber of large intestine" EXACT [FMA:15653]
xref: FMA:15653
is_a: CL:0002504 {is_inferred="true"} ! enteric smooth muscle cell
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0000059 ! large intestine
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000280
name: smooth muscle cell of colon
def: "A smooth muscle cell that is part of the colon." [GOC:tfm]
synonym: "non-striated muscle fiber of colon" EXACT [FMA:15663]
xref: FMA:15663
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0002504 ! enteric smooth muscle cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon

[Term]
id: CL:1000285
name: smooth muscle cell of sigmoid colon
def: "A smooth muscle cell that is part of the sigmoid colon." [GOC:tfm]
synonym: "non-striated muscle fiber of sigmoid colon" EXACT [FMA:17521]
xref: FMA:17521
is_a: CL:1000280 {is_inferred="true"} ! smooth muscle cell of colon
intersection_of: CL:1000280 ! smooth muscle cell of colon
intersection_of: part_of UBERON:0001159 ! sigmoid colon
relationship: part_of UBERON:0001159 ! sigmoid colon

[Term]
id: CL:1000286
name: smooth muscle cell of rectum
def: "A smooth muscle cell that is part of the rectum." [GOC:tfm]
synonym: "non-striated muscle fiber of rectum" EXACT [FMA:17522]
synonym: "smooth muscle fiber of rectum" EXACT []
xref: FMA:17522
is_a: CL:1000279 ! smooth muscle cell of large intestine
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0001052 ! rectum

[Term]
id: CL:1000296
name: epithelial cell of urethra
def: "An epithelial cell that is part of the urethra." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:256165
is_a: CL:0000066 ! epithelial cell
is_a: CL:1001320 ! urethra cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000057 ! urethra

[Term]
id: CL:1000303
name: fibroblast of areolar connective tissue
def: "A fibroblast that is part of the areolar connective tissue." [GOC:tfm]
xref: FMA:261279
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0006815 ! areolar connective tissue
relationship: part_of UBERON:0006815 ! areolar connective tissue

[Term]
id: CL:1000306
name: fibroblast of tunica adventitia of artery
def: "A fibroblast that is part of the tunica adventitia of artery." [GOC:tfm]
xref: FMA:261285
is_a: CL:0000057 {is_inferred="true"} ! fibroblast
is_a: CL:0002503 ! adventitial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005734 ! tunica adventitia of blood vessel
relationship: part_of UBERON:0005734 ! tunica adventitia of blood vessel

[Term]
id: CL:1000307
name: fibroblast of dense regular elastic tissue
def: "A fibroblast that is part of the dense regular elastic tissue." [GOC:tfm]
xref: FMA:261287
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0007846 ! dense regular connective tissue
relationship: part_of UBERON:0002521 ! elastic tissue
relationship: part_of UBERON:0007846 ! dense regular connective tissue

[Term]
id: CL:1000309
name: epicardial adipocyte
def: "An adipocyte that is part of the epicardial fat." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "adipocyte of epicardial fat" EXACT [FMA:261293]
synonym: "epicardial fat cell" EXACT [FMA:261293]
xref: FMA:261293
is_a: CL:0000136 ! adipocyte
is_a: CL:0002494 ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of UBERON:0002348 ! epicardium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000310
name: adipocyte of epicardial fat of right ventricle
def: "An adipocyte that is part of the epicardial fat of right ventricle." [GOC:tfm]
synonym: "epicardial adipocyte of right ventricle" EXACT [FMA:261297]
synonym: "epicardial fat cell of right ventricle" EXACT [FMA:261297]
xref: FMA:261297
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002080 ! heart right ventricle
relationship: part_of UBERON:0002080 ! heart right ventricle

[Term]
id: CL:1000311
name: adipocyte of epicardial fat of left ventricle
def: "An adipocyte that is part of the epicardial fat of left ventricle." [GOC:tfm]
subset: cellxgene_subset
synonym: "epicardial adipocyte of left ventricle" EXACT [FMA:261300]
synonym: "epicardial fat cell of left ventricle" EXACT [FMA:261300]
xref: FMA:261300
is_a: CL:1000309 ! epicardial adipocyte
intersection_of: CL:1000309 ! epicardial adipocyte
intersection_of: part_of UBERON:0002084 ! heart left ventricle
relationship: part_of UBERON:0002084 ! heart left ventricle

[Term]
id: CL:1000361
name: transitional myocyte of interatrial septum
def: "A transitional myocyte that is part of the interatrial septum." [GOC:tfm]
xref: FMA:263152
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002085 ! interatrial septum
relationship: part_of UBERON:0002085 ! interatrial septum

[Term]
id: CL:1000362
name: transitional myocyte of interventricular septum
def: "A transitional myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263154
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000376
name: Purkinje myocyte of interventricular septum
def: "A Purkinje myocyte that is part of the interventricular septum." [GOC:tfm]
xref: FMA:263182
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000398
name: endothelial cell of hepatic sinusoid
def: "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates." [GOC:tfm, PMID:3926620]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "endotheliocyte of hepatic sinusoid" EXACT [FMA:62911]
synonym: "liver sinusoidal endothelial cell" EXACT [PMID:30348985]
synonym: "LSEC" EXACT [PMID:30348985]
xref: BTO:000125
xref: FMA:62911
is_a: CL:0002262 ! endothelial cell of sinusoid
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001281 ! hepatic sinusoid
relationship: part_of UBERON:0001281 ! hepatic sinusoid
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000409
name: myocyte of sinoatrial node
def: "A muscle cell that is part of the sinoatrial node." [FMA:67102, GOC:tfm]
synonym: "SA nodal myocyte" EXACT [FMA:67102]
synonym: "SA node cardiac muscle cell" EXACT [GOC:pr]
synonym: "sinoatrial node cell" EXACT [GOC:pr]
synonym: "sinoatrial node myocyte" EXACT []
synonym: "sinuatrial node myocyte" EXACT [FMA:67102]
xref: FMA:67102
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002351 ! sinoatrial node
relationship: part_of UBERON:0002351 ! sinoatrial node

[Term]
id: CL:1000410
name: myocyte of atrioventricular node
def: "A muscle cell that is part of the atrioventricular node." [FMA:67106, GOC:tfm]
synonym: "atrioventricular node cell" EXACT [GOC:pr]
synonym: "atrioventricular node myocyte" EXACT [FMA:67106]
synonym: "AV nodal myocyte" EXACT [FMA:67106]
synonym: "AV node cardiac muscle cell" EXACT [GOC:pr]
synonym: "AV node cell" EXACT [GOC:pr]
xref: FMA:67106
is_a: CL:0002072 ! nodal myocyte
is_a: CL:0008009 ! transversely striated visceral muscle cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0000187 ! muscle cell
intersection_of: part_of UBERON:0002352 ! atrioventricular node
relationship: part_of UBERON:0002352 ! atrioventricular node

[Term]
id: CL:1000412
name: endothelial cell of arteriole
def: "An endothelial cell that is part of the arteriole." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:67760
xref: KUPO:0001097
is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001980 ! arteriole
relationship: part_of UBERON:0001980 ! arteriole
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000413
name: endothelial cell of artery
def: "A blood vessel endothelial cell that is part of an arterial endothelium." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "arterial endothelial cell" EXACT []
xref: BTO:0004758
xref: FMA:67761
xref: KUPO:0001095
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001917 ! endothelium of artery
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000414
name: endothelial cell of venule
def: "An endothelial cell that is part of the venule." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:67762
is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0001979 ! venule
relationship: part_of UBERON:0001979 ! venule
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000415
name: epithelial cell of gallbladder
def: "An epithelial cell that is part of the gallbladder." [GOC:tfm]
xref: FMA:67780
is_a: CL:0000066 ! epithelial cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: part_of UBERON:0002110 ! gallbladder

[Term]
id: CL:1000428
name: stem cell of epidermis
def: "A somatic stem cell that is part of the epidermis." [GOC:tfm]
subset: cellxgene_subset
synonym: "epidermal stem cell" EXACT [FMA:70541]
xref: FMA:70541
is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000723 ! somatic stem cell
intersection_of: part_of UBERON:0001003 ! skin epidermis
relationship: part_of UBERON:0001003 ! skin epidermis

[Term]
id: CL:1000443
name: ciliary muscle cell
def: "A smooth muscle cell that is part of the ciliary body." [GOC:tfm]
subset: cellxgene_subset
subset: eye_upper_slim
synonym: "smooth muscle cell of ciliary body" EXACT [FMA:70610]
xref: FMA:70610
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0001775 ! ciliary body
relationship: part_of UBERON:0001775 ! ciliary body

[Term]
id: CL:1000444
name: mesothelial cell of anterior chamber of eye
def: "A mesothelial cell that is part of the anterior chamber of eyeball." [GOC:tfm]
xref: FMA:70615
is_a: CL:0000077 ! mesothelial cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001766 ! anterior chamber of eyeball
relationship: part_of UBERON:0001766 ! anterior chamber of eyeball

[Term]
id: CL:1000449
name: epithelial cell of nephron
def: "An epithelial cell that is part of the nephron." [GOC:tfm]
subset: cellxgene_subset
xref: FMA:70965
is_a: CL:0002518 ! kidney epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001285 ! nephron
relationship: part_of UBERON:0001285 ! nephron

[Term]
id: CL:1000454
name: kidney collecting duct epithelial cell
def: "An epithelial cell that is part of the collecting duct of renal tubule." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
subset: kidney_upper_slim
synonym: "epithelial cell of renal collecting tubule" EXACT [FMA:70982]
xref: FMA:70982
xref: KUPO:0001059
is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1001225 {is_inferred="true"} ! kidney collecting duct cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000456
name: mesothelial cell of parietal peritoneum
def: "A mesothelial cell that is part of the parietal peritoneum." [GOC:tfm]
xref: FMA:72142
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001366 ! parietal peritoneum
relationship: part_of UBERON:0001366 ! parietal peritoneum

[Term]
id: CL:1000457
name: mesothelial cell of visceral peritoneum
def: "A mesothelial cell that is part of the visceral peritoneum." [GOC:tfm]
subset: human_reference_atlas
xref: FMA:72143
is_a: CL:1000490 ! mesothelial cell of peritoneum
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0001178 ! visceral peritoneum
relationship: part_of UBERON:0001178 ! visceral peritoneum
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000478
name: transitional myocyte of sinoatrial node
def: "A transitional myocyte that is part of the sinoatrial node." [GOC:tfm]
synonym: "transitinal myocyte of sinuatrial node" EXACT []
xref: FMA:83384
is_a: CL:0002073 {is_inferred="true"} ! transitional myocyte
is_a: CL:1000409 ! myocyte of sinoatrial node
intersection_of: CL:0002073 ! transitional myocyte
intersection_of: part_of UBERON:0002351 ! sinoatrial node

[Term]
id: CL:1000479
name: Purkinje myocyte of atrioventricular node
def: "A Purkinje myocyte that is part of the atrioventricular node." [GOC:tfm]
xref: FMA:83386
is_a: CL:0002068 {is_inferred="true"} ! Purkinje myocyte
is_a: CL:1000410 ! myocyte of atrioventricular node
intersection_of: CL:0002068 ! Purkinje myocyte
intersection_of: part_of UBERON:0002352 ! atrioventricular node

[Term]
id: CL:1000482
name: myocardial endocrine cell of interventricular septum
def: "A myocardial endocrine cell that is part of the interventricular septum." [GOC:tfm]
xref: FMA:83390
is_a: CL:0002074 {is_inferred="true"} ! myocardial endocrine cell
is_a: CL:2000022 ! cardiac septum cell
intersection_of: CL:0002074 ! myocardial endocrine cell
intersection_of: part_of UBERON:0002094 ! interventricular septum
relationship: part_of UBERON:0002094 ! interventricular septum

[Term]
id: CL:1000488
name: cholangiocyte
def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246]
subset: cellxgene_subset
synonym: "epithelial cell of bile duct" EXACT []
xref: FMA:86481
is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
intersection_of: part_of UBERON:0002394 ! bile duct
relationship: develops_from CL:0005026 ! hepatoblast
relationship: part_of UBERON:0002394 ! bile duct

[Term]
id: CL:1000490
name: mesothelial cell of peritoneum
def: "A mesothelial cell that is part of the peritoneum." [GOC:tfm]
synonym: "peritoneal mesothelial cell" EXACT [FMA:86736]
xref: FMA:86736
is_a: CL:0000077 ! mesothelial cell
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002358 ! peritoneum
relationship: part_of UBERON:0002358 ! peritoneum

[Term]
id: CL:1000491
name: mesothelial cell of pleura
def: "A mesothelial cell that is part of the pleura." [GOC:tfm]
subset: cellxgene_subset
synonym: "pleural mesothelial cell" EXACT [FMA:86737]
xref: FMA:86737
is_a: CL:0000077 ! mesothelial cell
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0000977 ! pleura
relationship: part_of UBERON:0000977 ! pleura

[Term]
id: CL:1000492
name: mesothelial cell of parietal pleura
def: "A mesothelial cell that is part of the parietal pleura." [GOC:tfm]
xref: FMA:86738
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002400 ! parietal pleura
relationship: part_of UBERON:0002400 ! parietal pleura

[Term]
id: CL:1000493
name: mesothelial cell of visceral pleura
def: "A mesothelial cell that is part of the visceral pleura." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
xref: FMA:86739
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:1000491 ! mesothelial cell of pleura
intersection_of: CL:0000077 ! mesothelial cell
intersection_of: part_of UBERON:0002401 ! visceral pleura
relationship: part_of UBERON:0002401 ! visceral pleura
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000494
name: nephron tubule epithelial cell
def: "An epithelial cell that is part of a nephron tubule." [GOC:tfm]
comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON.
subset: cellxgene_subset
synonym: "kidney tubule epithelial cell" EXACT []
xref: FMA:86785
xref: KUPO:0001022
is_a: CL:1000449 ! epithelial cell of nephron
is_a: CL:1000507 ! kidney tubule cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004810 ! nephron tubule epithelium
relationship: part_of UBERON:0004810 ! nephron tubule epithelium

[Term]
id: CL:1000497
name: kidney cell
def: "A cell that is part of a kidney." []
subset: cellxgene_subset
xref: KUPO:0001010
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002113 ! kidney
relationship: part_of UBERON:0002113 ! kidney

[Term]
id: CL:1000500
name: kidney interstitial cell
def: "A cell that is part of kidney interstitium." []
subset: cellxgene_subset
subset: kidney_upper_slim
xref: KUPO:0001013
is_a: CL:1000497 ! kidney cell
is_a: CL:4030031 ! interstitial cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0005215 ! kidney interstitium
relationship: part_of UBERON:0005215 ! kidney interstitium

[Term]
id: CL:1000505
name: kidney pelvis cell
def: "A cell that is part of a renal pelvis." []
subset: kidney_upper_slim
xref: KUPO:0001018
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001224 ! renal pelvis
relationship: part_of UBERON:0001224 ! renal pelvis

[Term]
id: CL:1000507
name: kidney tubule cell
def: "A cell that is part of a nephron tubule." []
subset: kidney_upper_slim
xref: KUPO:0001020
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001231 ! nephron tubule
relationship: part_of UBERON:0001231 ! nephron tubule

[Term]
id: CL:1000549
name: kidney cortex collecting duct epithelial cell
def: "An epithelial cell that is part of a cortical collecting duct." []
xref: KUPO:0001063
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004203 ! cortical collecting duct
relationship: part_of UBERON:0004203 ! cortical collecting duct

[Term]
id: CL:1000600
name: lower urinary tract cell
xref: KUPO:0001115
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001556 ! lower urinary tract
relationship: part_of UBERON:0001556 ! lower urinary tract

[Term]
id: CL:1000601
name: ureteral cell
xref: KUPO:0001116
is_a: CL:0000255 ! eukaryotic cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000056 ! ureter
relationship: part_of UBERON:0000056 ! ureter

[Term]
id: CL:1000606
name: kidney nerve cell
xref: KUPO:0001015
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: has_soma_location UBERON:0002113 ! kidney
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_soma_location UBERON:0002113 ! kidney

[Term]
id: CL:1000681
name: kidney cortex interstitial cell
xref: KUPO:0001091
is_a: CL:0002584 ! renal cortical epithelial cell
is_a: CL:1000500 {is_inferred="true"} ! kidney interstitial cell
intersection_of: CL:1000500 ! kidney interstitial cell
intersection_of: part_of UBERON:0005270 ! renal cortex interstitium
relationship: part_of UBERON:0005270 ! renal cortex interstitium

[Term]
id: CL:1000692
name: kidney interstitial fibroblast
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001102
is_a: CL:0000057 ! fibroblast
is_a: CL:1000500 ! kidney interstitial cell
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005215 ! kidney interstitium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000702
name: kidney pelvis smooth muscle cell
xref: KUPO:0001113
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000505 {is_inferred="true"} ! kidney pelvis cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0004227 ! kidney pelvis smooth muscle
relationship: part_of UBERON:0004227 ! kidney pelvis smooth muscle

[Term]
id: CL:1000708
name: ureter adventitial cell
subset: human_reference_atlas
xref: KUPO:0001119
is_a: CL:0000115 ! endothelial cell
is_a: CL:0002503 ! adventitial cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:1000601 ! ureteral cell
intersection_of: part_of UBERON:0001252 ! adventitia of ureter
relationship: part_of UBERON:0001252 ! adventitia of ureter
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000714
name: kidney cortex collecting duct principal cell
subset: human_reference_atlas
xref: KUPO:0001130
is_a: CL:1000549 {is_inferred="true"} ! kidney cortex collecting duct epithelial cell
is_a: CL:1001431 ! kidney collecting duct principal cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0004203 ! cortical collecting duct
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1000979
name: ureter smooth muscle cell
xref: KUPO:0001118
is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell
is_a: CL:1000601 {is_inferred="true"} ! ureteral cell
intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0006855 ! muscular coat of ureter
relationship: part_of UBERON:0006855 ! muscular coat of ureter

[Term]
id: CL:1001225
name: kidney collecting duct cell
def: "A cell that is part of a collecting duct of renal tubule." []
subset: cellxgene_subset
xref: KUPO:0001012
xref: Wikipedia:Kidney_collecting_duct_cell
is_a: CL:1000497 ! kidney cell
intersection_of: CL:1000497 ! kidney cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of UBERON:0001232 ! collecting duct of renal tubule

[Term]
id: CL:1001319
name: bladder cell
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001120
is_a: CL:1000600 ! lower urinary tract cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
relationship: part_of UBERON:0001255 ! urinary bladder
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1001320
name: urethra cell
xref: KUPO:0001123
is_a: CL:1000600 ! lower urinary tract cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000057 ! urethra
relationship: part_of UBERON:0000057 ! urethra

[Term]
id: CL:1001431
name: kidney collecting duct principal cell
subset: cellxgene_subset
subset: human_reference_atlas
xref: KUPO:0001128
is_a: CL:0005009 {is_inferred="true"} ! renal principal cell
is_a: CL:1000454 ! kidney collecting duct epithelial cell
intersection_of: CL:0005009 ! renal principal cell
intersection_of: part_of UBERON:0001232 ! collecting duct of renal tubule
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1001433
name: epithelial cell of exocrine pancreas
def: "An epithelial cell of the exocrine pancreas." [GOC:tfm]
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "exocrine pancreas cell" EXACT []
xref: FMA:70986
is_a: CL:0000083 ! epithelial cell of pancreas
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0000017 ! exocrine pancreas
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1001516
name: intestinal enteroendocrine cell
def: "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract." [MP:0010802]
subset: cellxgene_subset
is_a: CL:0000164 ! enteroendocrine cell
is_a: CL:0002563 ! intestinal epithelial cell
intersection_of: CL:0000164 ! enteroendocrine cell
intersection_of: part_of UBERON:0001242 ! intestinal mucosa

[Term]
id: CL:1001567
name: lung endothelial cell
synonym: "endothelial cell of lung" RELATED []
synonym: "pulmonary vessel endothelial cell" RELATED []
is_a: CL:0000082 ! epithelial cell of lung
is_a: CL:0002139 ! endothelial cell of vascular tree
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0000102 ! lung vasculature

[Term]
id: CL:1001568
name: pulmonary artery endothelial cell
subset: cellxgene_subset
subset: human_reference_atlas
synonym: "PAEC cell" RELATED [BTO:0001141]
xref: BTO:0001141
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:0002139 ! endothelial cell of vascular tree
intersection_of: part_of UBERON:0002012 ! pulmonary artery
relationship: part_of UBERON:0005317 ! pulmonary artery endothelium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1001572
name: colon endothelial cell
def: "A vascular endothelial cell found in colon blood vessels." [https://orcid.org/0000-0001-5208-3432, NPX:PDR]
synonym: "colon endothelial cells" RELATED OMO:0003004 [CALOHA:TS-2397]
synonym: "colonic endothelial cell" RELATED [CALOHA:TS-2397]
xref: CALOHA:TS-2397
is_a: CL:0000115 ! endothelial cell
is_a: CL:0011108 ! colon epithelial cell
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0013695 ! colon endothelium

[Term]
id: CL:1001576
name: oral mucosa squamous cell
def: "Squamous cell of oral epithelium." [NPX:PDR]
synonym: "oral cavity mucosa squamous cell" RELATED [CALOHA:TS-1252]
synonym: "oral cavity mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cell" RELATED [CALOHA:TS-1252]
synonym: "oral mucosa squamous epithelial cells" RELATED [CALOHA:TS-1252]
xref: CALOHA:TS-1252
is_a: CL:0000076 ! squamous epithelial cell
is_a: CL:0002251 ! epithelial cell of alimentary canal
intersection_of: CL:0000076 ! squamous epithelial cell
intersection_of: part_of UBERON:0002424 ! oral epithelium
relationship: part_of UBERON:0002424 ! oral epithelium

[Term]
id: CL:1001588
name: colon glandular cell
def: "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "colon glandular cells" RELATED [CALOHA:TS-1274]
xref: CALOHA:TS-1274
is_a: CL:0002658 ! glandular cell of the large intestine
is_a: CL:0011108 ! colon epithelial cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001155 ! colon

[Term]
id: CL:1001589
name: duodenum glandular cell
def: "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell." [NPX:PDR]
subset: cellxgene_subset
synonym: "duodenum glandular cells" RELATED [CALOHA:TS-1275]
xref: CALOHA:TS-1275
is_a: CL:1001598 ! small intestine glandular cell
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0008346 ! duodenal epithelium

[Term]
id: CL:1001590
name: epididymis glandular cell
def: "Glandular cell of epididymal epithelium." [NPX:PDR]
synonym: "epididymal glandular cell" RELATED [CALOHA:TS-1276]
synonym: "epididymis glandular cells" RELATED [CALOHA:TS-1276]
xref: CALOHA:TS-1276
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001301 ! epididymis
relationship: part_of UBERON:0004544 ! epididymis epithelium

[Term]
id: CL:1001591
name: oviduct glandular cell
name: oviduct secretory cell
def: "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells." [HPA:HPA, NPX:PDR]
synonym: "fallopian tube glandular cell" RELATED [CALOHA:TS-1277]
synonym: "fallopian tube glandular cells" RELATED [CALOHA:TS-1277]
synonym: "oviduct glandular cell" RELATED []
synonym: "uterine tube glandular cell" RELATED [CALOHA:TS-1277]
xref: CALOHA:TS-1277
is_a: CL:0000150 ! glandular epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: CL:1100001 ! secretory epithelial cell
intersection_of: part_of UBERON:0000993 ! oviduct
intersection_of: part_of UBERON:0000993 ! oviduct
relationship: part_of UBERON:0004804 ! oviduct epithelium

[Term]
id: CL:1001592
name: gallbladder glandular cell
def: "Glandular cell of gallbladder epithelium." [NPX:PDR]
synonym: "gall bladder glandular cell" EXACT [FMA:7202]
synonym: "gall bladder glandular cells" RELATED [CALOHA:TS-1278]
synonym: "gallbladder glandular cells" RELATED [CALOHA:TS-1278]
xref: CALOHA:TS-1278
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:1000415 ! epithelial cell of gallbladder
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: part_of UBERON:0002029 ! epithelium of gall bladder

[Term]
id: CL:1001595
name: rectum glandular cell
def: "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells." [NPX:PDR]
synonym: "rectal glandular cell" RELATED [CALOHA:TS-1281]
synonym: "rectum glandular cells" RELATED [CALOHA:TS-1281]
xref: CALOHA:TS-1281
is_a: CL:0002658 ! glandular cell of the large intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0001052 ! rectum
relationship: part_of UBERON:0003354 ! epithelium of rectum

[Term]
id: CL:1001597
name: seminal vesicle glandular cell
def: "Glandular cell of seminal vesicle epithelium." [NPX:PDR]
subset: cellxgene_subset
synonym: "seminal vesicle glandular cells" RELATED [CALOHA:TS-1283]
xref: CALOHA:TS-1283
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0000150 ! glandular epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000998 ! seminal vesicle
relationship: part_of UBERON:0004805 ! seminal vesicle epithelium

[Term]
id: CL:1001598
name: small intestine glandular cell
def: "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." [NCI_Thesaurus:Small_Intestinal_Glandular_Cell, NPX:PDR]
synonym: "small bowel glandular cell" RELATED [CALOHA:TS-1286]
synonym: "small intestinal glandular cell" RELATED [CALOHA:TS-1286]
synonym: "small intestine glandular cells" RELATED [CALOHA:TS-1286]
xref: CALOHA:TS-1286
xref: FMA:86928
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0002254 ! epithelial cell of small intestine
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0002108 ! small intestine
relationship: part_of UBERON:0001902 ! epithelium of small intestine

[Term]
id: CL:1001599
name: pancreas exocrine glandular cell
def: "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts." [HPA:HPA, NPX:PDR]
subset: human_reference_atlas
synonym: "exocrine pancreas glandular cell" RELATED [CALOHA:TS-1242]
synonym: "pancreas exocrine glandular cells" RELATED [CALOHA:TS-1242]
xref: BTO:0000028
xref: CALOHA:TS-1242
is_a: CL:0000150 ! glandular epithelial cell
is_a: CL:0000152 ! exocrine cell
is_a: CL:1001433 ! epithelial cell of exocrine pancreas
intersection_of: CL:0000150 ! glandular epithelial cell
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
relationship: part_of UBERON:0013697 ! exocrine pancreas epithelium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: CL:1001609
name: muscle fibroblast
def: "Fibroblast from muscle organ." [NPX:PDR]
xref: CALOHA:TS-0643
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0001630 ! muscle organ

[Term]
id: CL:1001610
name: bone marrow hematopoietic cell
def: "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." [NPX:PDR]
synonym: "bone marrow hematopoietic cells" RELATED [CALOHA:TS-2109]
synonym: "bone marrow poietic cells" RELATED [CALOHA:TS-2109]
xref: CALOHA:TS-2109
is_a: CL:0000988 ! hematopoietic cell
is_a: CL:0002092 ! bone marrow cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: part_of UBERON:0002371 ! bone marrow
relationship: part_of UBERON:0012429 ! hematopoietic tissue

[Term]
id: CL:1100001
name: secretory epithelial cell
def: "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules." [https://orcid.org/0000-0002-7073-9172]
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000151 ! secretory cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: CL:0000151 ! secretory cell
property_value: term:contributor https://orcid.org/0000-0002-7073-9172
property_value: term:date "2024-07-21T09:24:44Z" xsd:dateTime

[Term]
id: CL:2000001
name: peripheral blood mononuclear cell
def: "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000080 ! circulating cell
is_a: CL:0000842 ! mononuclear cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0000178 ! blood
relationship: part_of UBERON:0000178 ! blood
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-02-11T17:29:04Z

[Term]
id: CL:2000002
name: decidual cell
def: "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization." [BTO:0002770, NCIT:C32429, PMID:30013421, PMID:30429548, Wiki:Decidual_cells&oldid=937509751, Wiki:Decidualization&oldid=908981933]
subset: cellxgene_subset
synonym: "decidua cell" EXACT [BTO:0002770, NCIT:C32429]
synonym: "decidual stromal cell" EXACT [BTO:0005756, PMID:11719592]
xref: BTO:0002770
xref: BTO:0005756
xref: NCIT:C32429
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000499 ! stromal cell
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from CL:0002255 ! stromal cell of endometrium
relationship: part_of UBERON:0002450 ! decidua
creation_date: 2014-02-20T23:06:41Z

[Term]
id: CL:2000008
name: microvascular endothelial cell
def: "Any blood vessel endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
is_a: CL:0000071 ! blood vessel endothelial cell
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
relationship: part_of UBERON:0008339 ! microvascular endothelium
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-04T15:07:42Z

[Term]
id: CL:2000010
name: dermis blood vessel endothelial cell
def: "Any blood vessel endothelial cell that is part of a dermis." [GOC:TermGenie]
is_a: CL:0000071 ! blood vessel endothelial cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000071 ! blood vessel endothelial cell
intersection_of: part_of UBERON:0002067 ! dermis
relationship: part_of UBERON:0002067 ! dermis
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-04T15:12:06Z

[Term]
id: CL:2000013
name: fibroblast of skin of abdomen
def: "Any skin fibroblast that is part of a skin of abdomen." [GOC:TermGenie]
is_a: CL:0002620 ! skin fibroblast
intersection_of: CL:0002620 ! skin fibroblast
intersection_of: part_of UBERON:0001416 ! skin of abdomen
relationship: part_of UBERON:0001416 ! skin of abdomen
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-04T15:18:16Z

[Term]
id: CL:2000016
name: lung microvascular endothelial cell
def: "Any lung endothelial cell that is part of a microvascular endothelium." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:1001567 ! lung endothelial cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:1001567 ! lung endothelial cell
intersection_of: part_of UBERON:0008339 ! microvascular endothelium
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-04T16:00:56Z

[Term]
id: CL:2000019
name: compound eye photoreceptor cell
def: "Any photoreceptor cell that is part of a compound eye." [GOC:TermGenie]
xref: FBbt:00004211
is_a: CL:0000287 ! eye photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000018 ! compound eye
relationship: part_of UBERON:0000018 ! compound eye
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-24T23:16:45Z

[Term]
id: CL:2000020
name: inner cell mass cell
def: "Any native cell that is part of a inner cell mass." [GOC:TermGenie]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0000087 ! inner cell mass
relationship: part_of UBERON:0000087 ! inner cell mass
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-24T23:16:53Z

[Term]
id: CL:2000022
name: cardiac septum cell
def: "Any native cell that is part of a cardiac septum." [GOC:TermGenie]
is_a: CL:0002494 ! cardiocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0002099 ! cardiac septum
relationship: part_of UBERON:0002099 ! cardiac septum
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-24T23:17:07Z

[Term]
id: CL:2000029
name: central nervous system neuron
def: "Any neuron that is part of a central nervous system." [GOC:TermGenie]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: has_soma_location UBERON:0001017 ! central nervous system
relationship: has_soma_location UBERON:0001017 ! central nervous system
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-25T01:17:43Z

[Term]
id: CL:2000032
name: peripheral nervous system neuron
def: "A neuron that is part of a peripheral nervous system." [GOC:TermGenie, ISBN:0721662544]
subset: cellxgene_subset
synonym: "peripheral neuron" EXACT []
synonym: "PNS neuron" EXACT []
xref: FMA:84664
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: has_soma_location UBERON:0000010 ! peripheral nervous system
relationship: has_soma_location UBERON:0000010 ! peripheral nervous system
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-06-25T02:28:17Z

[Term]
id: CL:2000040
name: bladder microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a urinary bladder." [GOC:TermGenie]
subset: human_reference_atlas
is_a: CL:1001319 ! bladder cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001255 ! urinary bladder
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-07-09T00:04:47Z

[Term]
id: CL:2000042
name: embryonic fibroblast
def: "Any fibroblast that is part of a embryo." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0000922 ! embryo
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-07-09T00:12:00Z

[Term]
id: CL:2000044
name: brain microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a brain." [GOC:TermGenie]
is_a: CL:0002319 ! neural cell
is_a: CL:2000008 ! microvascular endothelial cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0000955 ! brain
relationship: part_of UBERON:0000955 ! brain
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-07-09T00:24:53Z

[Term]
id: CL:2000046
name: ventricular cardiac muscle cell
def: "Any cardiac muscle cell that is part of a cardiac ventricle." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0000746 ! cardiac muscle cell
intersection_of: CL:0000746 ! cardiac muscle cell
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-08-12T20:50:28Z

[Term]
id: CL:2000047
name: brainstem motor neuron
def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie]
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
intersection_of: has_soma_location UBERON:0002298 ! brainstem
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_soma_location UBERON:0002298 ! brainstem
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-02T23:52:53Z

[Term]
id: CL:2000051
name: splenic fibroblast
def: "Any fibroblast that is part of a spleen." [GOC:TermGenie]
is_a: CL:0000057 ! fibroblast
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-06T18:58:47Z

[Term]
id: CL:2000052
name: umbilical artery endothelial cell
def: "Any endothelial cell of artery that is part of a umbilical cord." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=8010
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:1000413 ! endothelial cell of artery
intersection_of: CL:1000413 ! endothelial cell of artery
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-06T19:01:48Z

[Term]
id: CL:2000053
name: splenic endothelial cell
def: "Any endothelial cell that is part of a spleen." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5500
subset: human_reference_atlas
is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-06T19:06:04Z

[Term]
id: CL:2000055
name: liver dendritic cell
def: "Any dendritic cell that is part of a liver." [GOC:TermGenie]
comment: http://www.jleukbio.org/content/66/2/322.abstract
subset: cellxgene_subset
synonym: "hepatic dendritic cell" EXACT []
is_a: CL:0000451 ! dendritic cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000451 ! dendritic cell
intersection_of: part_of UBERON:0002107 ! liver
relationship: part_of UBERON:0002107 ! liver
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-06T19:16:11Z

[Term]
id: CL:2000061
name: placental amniotic mesenchymal stromal cell
def: "Any mesenchymal stem cell that is part of a placenta." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7140
subset: human_reference_atlas
is_a: CL:0000134 ! mesenchymal stem cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000134 ! mesenchymal stem cell
intersection_of: part_of UBERON:0001987 ! placenta
relationship: part_of UBERON:0001987 ! placenta
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T17:51:11Z

[Term]
id: CL:2000063
name: ovarian fibroblast
def: "Any fibroblast that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7330
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0000992 ! ovary
relationship: part_of UBERON:0000992 ! ovary
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T17:57:42Z

[Term]
id: CL:2000064
name: ovarian surface epithelial cell
def: "Any epithelial cell that is part of a female gonad." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7310
subset: cellxgene_subset
is_a: CL:0000066 ! epithelial cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000992 ! ovary
relationship: part_of UBERON:0000992 ! ovary
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T17:59:13Z

[Term]
id: CL:2000065
name: ovarian microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a female urethra." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7300
is_a: CL:1000296 ! epithelial cell of urethra
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001334 ! female urethra
relationship: part_of UBERON:0001334 ! female urethra
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:18:01Z

[Term]
id: CL:2000066
name: cardiac ventricle fibroblast
def: "Any fibroblast that is part of a cardiac ventricle." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6310
subset: human_reference_atlas
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:35:38Z

[Term]
id: CL:2000067
name: cardiac atrium fibroblast
def: "Any fibroblast that is part of a cardiac atrium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6320
subset: human_reference_atlas
is_a: CL:0002548 ! fibroblast of cardiac tissue
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002081 ! cardiac atrium
relationship: part_of UBERON:0002081 ! cardiac atrium
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:36:54Z

[Term]
id: CL:2000068
name: pericardium fibroblast
def: "Any fibroblast that is part of a pericardium." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6430
is_a: CL:0000057 ! fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002407 ! pericardium
relationship: part_of UBERON:0002407 ! pericardium
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:38:06Z

[Term]
id: CL:2000069
name: gallbladder fibroblast
def: "Any fibroblast that is part of a gallbladder." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=5430
is_a: CL:0000057 ! fibroblast
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0002110 ! gallbladder
relationship: part_of UBERON:0002110 ! gallbladder
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:41:43Z

[Term]
id: CL:2000070
name: optic choroid fibroblast
def: "Any fibroblast that is part of a optic choroid." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=6620
is_a: CL:0000057 ! fibroblast
is_a: UBERON:0010313 ! neural crest-derived structure
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0001776 ! optic choroid
relationship: part_of UBERON:0001776 ! optic choroid
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T18:50:43Z

[Term]
id: CL:2000072
name: adipose microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a adipose tissue." [GOC:TermGenie]
comment: http://www.sciencellonline.com/site/productInformation.php?keyword=7200
is_a: CL:0002320 ! connective tissue cell
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0001013 ! adipose tissue
relationship: part_of UBERON:0001013 ! adipose tissue
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-10-07T22:13:45Z

[Term]
id: CL:2000073
name: migratory cardiac neural crest cell
def: "Any migratory neural crest cell that is part of a cardiac neural crest." [GOC:TermGenie]
synonym: "cardiac neural crest cell" EXACT [PMID:33060096]
is_a: CL:0000333 ! migratory neural crest cell
intersection_of: CL:0000333 ! migratory neural crest cell
intersection_of: part_of UBERON:0000095 ! cardiac neural crest
relationship: part_of UBERON:0000095 ! cardiac neural crest
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-11-05T01:18:43Z

[Term]
id: CL:2000074
name: splenocyte
def: "Any leukocyte that is part of a spleen." [GOC:TermGenie]
comment: Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology.
is_a: CL:0000738 ! leukocyte
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000738 ! leukocyte
intersection_of: part_of UBERON:0002106 ! spleen
relationship: part_of UBERON:0002106 ! spleen
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-11-05T01:26:50Z

[Term]
id: CL:2000080
name: mesenchymal stem cell of abdominal adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an abdomen." [GOC:TermGenie]
synonym: "mesenchymal stem cell of abdominal adipose" EXACT []
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: part_of UBERON:0000916 ! abdomen
relationship: part_of UBERON:0000916 ! abdomen
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-12-02T19:10:34Z

[Term]
id: CL:2000085
name: mononuclear cell of umbilical cord
def: "Any mononuclear cell that is part of a umbilical cord." [GOC:TermGenie]
is_a: CL:0000349 ! extraembryonic cell
is_a: CL:0000842 ! mononuclear cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000842 ! mononuclear cell
intersection_of: part_of UBERON:0002331 ! umbilical cord
relationship: part_of UBERON:0002331 ! umbilical cord
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2014-12-02T20:14:16Z

[Term]
id: CL:2000091
name: endometrial microvascular endothelial cell
def: "Any microvascular endothelial cell that is part of a endometrial blood vessel." [GOC:TermGenie]
subset: human_reference_atlas
is_a: CL:0009095 ! endothelial cell of uterus
is_a: CL:2000008 ! microvascular endothelial cell
intersection_of: CL:2000008 ! microvascular endothelial cell
intersection_of: part_of UBERON:0015172 ! endometrial blood vessel
relationship: part_of UBERON:0015172 ! endometrial blood vessel
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2015-03-31T21:02:36Z

[Term]
id: CL:2000095
name: cord blood hematopoietic stem cell
def: "Any hematopoietic stem cell that is part of a umbilical cord blood." [GOC:TermGenie]
subset: cellxgene_subset
is_a: CL:0002246 ! peripheral blood stem cell
is_a: CL:0002352 ! gestational hematopoietic stem cell
intersection_of: CL:0000037 ! hematopoietic stem cell
intersection_of: part_of UBERON:0012168 ! umbilical cord blood
relationship: part_of UBERON:0012168 ! umbilical cord blood
property_value: term:contributor https://www.wikidata.org/entity/Q35563349
creation_date: 2015-05-26T18:58:34Z

[Term]
id: CL:3000000
name: ciliated epithelial cell of esophagus
def: "A ciliated epithelial cell of the esophagus." [GOC:CellBLAST, PMID:29802404]
is_a: CL:0000067 ! ciliated epithelial cell
is_a: CL:0002252 ! epithelial cell of esophagus
intersection_of: CL:0000067 ! ciliated epithelial cell
intersection_of: part_of UBERON:0001976 ! epithelium of esophagus
relationship: part_of UBERON:0001976 ! epithelium of esophagus
property_value: term:contributor https://www.wikidata.org/entity/Q97529981
creation_date: 2019-02-09T16:40:30Z

[Term]
id: CL:3000004
name: peripheral sensory neuron
def: "Peripheral sensory neuron." [GOC:CellBLAST, PMID:30096314]
is_a: CL:0000101 ! sensory neuron
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:2000032 ! peripheral nervous system neuron
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
property_value: term:contributor https://www.wikidata.org/entity/Q97529981
creation_date: 2019-02-25T19:34:33Z

[Term]
id: CL:4023072
name: brain vascular cell
def: "A cell that is part of the brain vasculature." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
is_a: CL:0002319 ! neural cell
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0008998 ! vasculature of brain
relationship: part_of UBERON:0008998 ! vasculature of brain
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor http://orcid.org/0000-0001-7258-9596

[Term]
id: CL:4023079
name: midbrain-derived inhibitory neuron
def: "A GABAergic inhibitory neuron that is derived from the midbrain." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
is_a: CL:0000540 ! neuron
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from UBERON:0001891 ! midbrain
relationship: develops_from UBERON:0001891 ! midbrain
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor http://orcid.org/0000-0001-7258-9596

[Term]
id: CL:4023168
name: somatosensory neuron
def: "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli." [PMID:22865660]
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: part_of UBERON:0003942 ! somatosensory system
relationship: part_of UBERON:0003942 ! somatosensory system
property_value: term:contributor http://orcid.org/0000-0001-7258-9596

[Term]
id: CL:4028001
name: pulmonary capillary endothelial cell
def: "Any capillary endothelial cell that is part of a lung." []
synonym: "lung capillary endothelial cell" EXACT []
is_a: CL:0002144 ! capillary endothelial cell
is_a: CL:2000016 ! lung microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0016405 ! pulmonary capillary
property_value: term:contributor https://orcid.org/0000-0002-3293-5463
creation_date: 2021-11-23T02:31:40Z

[Term]
id: CL:4030025
name: renal cortical fibroblast
def: "A fibroblast that is located in the renal cortical interstitium." [PMID:10559635]
comment: Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin. {xref="PMID:16230044"}
synonym: "kidney cortical fibroblast" EXACT []
is_a: CL:1000681 ! kidney cortex interstitial cell
is_a: CL:1000692 ! kidney interstitial fibroblast
intersection_of: CL:0000057 ! fibroblast
intersection_of: part_of UBERON:0005270 ! renal cortex interstitium
property_value: term:date "2022-07-05T15:50:17Z" xsd:dateTime

[Term]
id: CL:4030029
name: blood lymphocyte
def: "A lymphocyte located in blood." [https://orcid.org/0000-0001-9990-8331]
subset: blood_and_immune_upper_slim
is_a: CL:0000542 ! lymphocyte
is_a: CL:2000001 ! peripheral blood mononuclear cell
intersection_of: CL:0000542 ! lymphocyte
intersection_of: part_of UBERON:0000178 ! blood
property_value: term:date "2022-11-04T14:40:00Z" xsd:dateTime

[Term]
id: CL:4030031
name: interstitial cell
def: "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes." [PMID:24987007]
is_a: CL:0000255 ! eukaryotic cell
intersection_of: CL:0000000 ! cell
intersection_of: part_of UBERON:0005169 ! interstitial tissue
relationship: part_of UBERON:0005169 ! interstitial tissue
property_value: term:date "2022-11-30T14:35:08Z" xsd:dateTime

[Term]
id: CL:4030034
name: respiratory ciliated cell
def: "A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium." [PMID:18757316, PMID:21364219]
synonym: "ciliated cell of the respiratory tract" EXACT []
is_a: CL:0000064 ! ciliated cell
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: CL:0000064 ! ciliated cell
intersection_of: part_of UBERON:0004802 ! respiratory tract epithelium
relationship: part_of UBERON:0004802 ! respiratory tract epithelium
property_value: term:date "2023-01-25T11:06:01Z" xsd:dateTime

[Term]
id: CL:4030040
name: endometrial ciliated epithelial cell
def: "A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium." [doi:10.1038/s41591-020-1040-z, https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells]
comment: In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted. {xref="ttps://www.nature.com/articles/s41591-020-1040-z"}
synonym: "ciliated cell of the endometrium" EXACT []
synonym: "ciliated cell of the uterus" BROAD []
synonym: "endometrium ciliated epithelial cell" EXACT []
synonym: "uterine ciliated cell" BROAD []
is_a: CL:0000067 ! ciliated epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000064 ! ciliated cell
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0004811 ! endometrium epithelium
relationship: part_of UBERON:0004811 ! endometrium epithelium
property_value: term:date "2023-02-09T11:25:14Z" xsd:dateTime

[Term]
id: CL:4030066
name: ureteric bud cell
def: "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion." [PMID:17133361, PMID:24183650, PMID:9374839]
synonym: "UB cell" RELATED OMO:0003000 [PMID:24183650]
is_a: CL:0000068 ! duct epithelial cell
is_a: CL:0002518 ! kidney epithelial cell
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: CL:0000066 ! epithelial cell
intersection_of: part_of UBERON:0000084 ! ureteric bud
relationship: part_of UBERON:0000084 ! ureteric bud
relationship: participates_in GO:2001013 {xref="PMID:9374839"} ! epithelial cell proliferation involved in renal tubule morphogenesis
property_value: term:contributor "https://orcid.org/0000-0002-1425-877X" xsd:string
property_value: term:date "2023-10-13T11:22:42Z" xsd:dateTime

[Term]
id: CL:4033008
name: vein endothelial cell of respiratory system
def: "A(n) vein endothelial cell that is part of a(n) respiratory system." [PMID:34030460]
subset: human_reference_atlas
is_a: CL:0002543 ! vein endothelial cell
intersection_of: CL:0002543 ! vein endothelial cell
intersection_of: part_of UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0001-6677-8489

[Term]
id: CL:4033018
name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116]
subset: human_reference_atlas
synonym: "lung MKs" RELATED OMO:0003004 [PMID:33351116]
synonym: "lung resident megakaryocyte" EXACT [PMID:36524131]
synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131]
synonym: "MKL" RELATED OMO:0003000 [PMID:36524131]
is_a: CL:0000556 ! megakaryocyte
is_a: CL:0002320 ! connective tissue cell
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000556 ! megakaryocyte
intersection_of: part_of UBERON:0000114 ! lung connective tissue
relationship: part_of UBERON:0000114 ! lung connective tissue
property_value: RO:0002175 NCBITaxon:9606
property_value: term:contributor https://orcid.org/0000-0001-6677-8489
property_value: term:contributor https://orcid.org/0000-0002-9185-3994
property_value: term:date "2023-03-16T11:31:23Z" xsd:dateTime

[Term]
id: CL:4033050
name: catecholaminergic neuron
def: "A neuron that releases catecholamine as a neurotransmitter." [ISBN:0521442516, PMID:12094209]
comment: Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis. {xref="https://orcid.org/0000-0002-2244-7917", xref="PMID:12128258", xref="PMID:10191060", xref="PMID:34880760"}
is_a: CL:0000151 ! secretory cell
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: capable_of GO:0160043 ! catecholamine secretion, neurotransmission
relationship: capable_of GO:0160043 ! catecholamine secretion, neurotransmission
property_value: term:contributor https://orcid.org/0000-0001-6677-8489
property_value: term:date "2023-05-18T12:07:45Z" xsd:dateTime

[Term]
id: CL:4033054
name: perivascular cell
def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329]
is_a: CL:0000000 ! cell
intersection_of: CL:0000000 ! cell
intersection_of: adjacent_to UBERON:0002049 ! vasculature
relationship: adjacent_to UBERON:0002049 ! vasculature
property_value: term:contributor https://orcid.org/0000-0001-6677-8489
property_value: term:date "2023-08-22T13:40:28Z" xsd:dateTime

[Term]
id: CL:4033061
name: endothelial cell of central vein of liver
def: "An endothelial cell that is part of a central vein of liver." [PMID:28287163]
synonym: "endothelial cell of central vein" BROAD [PMID:28287163]
is_a: CL:0000115 ! endothelial cell
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0006841 ! central vein of liver
relationship: part_of UBERON:0006841 ! central vein of liver
property_value: term:contributor https://orcid.org/0000-0001-6677-8489

[Term]
id: CL:4040004
name: mesenchymal stem cell of orbital adipose tissue
def: "Any mesenchymal stem cell of adipose tissue that is part of an orbital region." [https://orcid.org/0000-0002-0819-0473]
synonym: "OAMSC" EXACT [PMID:31377878]
synonym: "orbital adipose-derived mesenchymal stem cell" EXACT [PMID:31377878]
synonym: "Orbital ASCs" EXACT [PMID:30210548]
is_a: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: CL:0002570 ! mesenchymal stem cell of adipose tissue
intersection_of: part_of UBERON:0004088 ! orbital region
relationship: part_of UBERON:0004088 ! orbital region
property_value: term:contributor https://orcid.org/0000-0002-0819-0473
property_value: term:date "2023-09-18T10:43:00Z" xsd:dateTime

[Term]
id: GO:0000003
name: reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_pir
subset: goslim_plant
synonym: "reproductive physiological process" EXACT []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological process

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: results_in_distribution_of GO:0005773 ! vacuole
relationship: results_in_distribution_of GO:0005773 ! vacuole
property_value: RO:0002161 NCBITaxon:4896

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
alt_id: GO:0016359
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]
subset: goslim_pombe
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0140014 ! mitotic nuclear division
relationship: part_of GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
synonym: "Golgi apparatus membrane" EXACT []
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005794 ! Golgi apparatus
relationship: bounding_layer_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_pombe
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0015630 ! microtubule cytoskeleton
relationship: results_in_organization_of GO:0015630 ! microtubule cytoskeleton
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23114" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23195" xsd:anyURI

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators]
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:18154 ! polysaccharide
relationship: has_primary_output CHEBI:18154 ! polysaccharide

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
alt_id: GO:0044244
def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]
synonym: "multicellular organismal polysaccharide catabolic process" NARROW []
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:18154 ! polysaccharide
relationship: has_primary_input CHEBI:18154 ! polysaccharide

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
alt_id: GO:0007067
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_yeast
synonym: "mitosis" RELATED []
xref: Wikipedia:Mitosis
is_a: GO:0007049 ! cell cycle
intersection_of: GO:0007049 ! cell cycle
intersection_of: has_part GO:0140014 ! mitotic nuclear division
relationship: has_part GO:0140014 ! mitotic nuclear division
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: results_in_fission_of GO:0005634 ! nucleus
relationship: results_in_fission_of GO:0005634 ! nucleus

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0043226 ! organelle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0000578
name: embryonic axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: results_in_fusion_of GO:0031965 ! nuclear membrane
relationship: results_in_fusion_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0048284 ! organelle fusion
intersection_of: results_in_fusion_of GO:0005634 ! nucleus
relationship: part_of GO:0006997 ! nucleus organization
relationship: results_in_fusion_of GO:0005634 ! nucleus

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
is_a: GO:0006949 ! syncytium formation
is_a: GO:0140253 ! cell-cell fusion
intersection_of: GO:0006949 ! syncytium formation
intersection_of: has_part GO:0045026 ! plasma membrane fusion

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
alt_id: GO:0000789
alt_id: GO:0000790
alt_id: GO:0005717
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
synonym: "chromosome scaffold" RELATED []
synonym: "cytoplasmic chromatin" NARROW []
synonym: "nuclear chromatin" NARROW []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0032993 ! protein-DNA complex
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
alt_id: GO:0005720
alt_id: GO:0035328
def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]
synonym: "nuclear heterochromatin" NARROW []
synonym: "transcriptionally inactive chromatin" EXACT []
synonym: "transcriptionally silent chromatin" EXACT []
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22355" xsd:anyURI

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0098813 ! nuclear chromosome segregation

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of CL:0000000 ! cell
relationship: results_in_morphogenesis_of CL:0000000 ! cell

[Term]
id: GO:0001101
name: response to acid chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn]
comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead.
subset: gocheck_do_not_manually_annotate
synonym: "response to acid" BROAD []
synonym: "response to acid anion" RELATED []
synonym: "response to oxoanion" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001434 ! skeletal system
relationship: results_in_development_of UBERON:0001434 ! skeletal system

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032501 ! multicellular organismal process
intersection_of: GO:0032501 ! multicellular organismal process
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001474 ! bone element
relationship: results_in_formation_of_anatomical_entity UBERON:0001474 ! bone element

[Term]
id: GO:0001508
name: action potential
namespace: biological_process
def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.
is_a: GO:0042391 ! regulation of membrane potential
property_value: RO:0002161 NCBITaxon:4895

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel
relationship: part_of GO:0048514 ! blood vessel morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel

[Term]
id: GO:0001539
name: cilium or flagellum-dependent cell motility
namespace: biological_process
def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "ciliary or bacterial-type flagellar motility" RELATED []
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001553
name: luteinization
namespace: biological_process
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of CL:0000023 ! oocyte
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048599 ! oocyte development
relationship: results_in_growth_of CL:0000023 ! oocyte

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000023 ! oocyte
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048599 ! oocyte development
relationship: results_in_maturation_of CL:0000023 ! oocyte

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016049 ! cell growth
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001981 ! blood vessel
relationship: part_of GO:0001944 ! vasculature development
relationship: results_in_development_of UBERON:0001981 ! blood vessel

[Term]
id: GO:0001569
name: branching involved in blood vessel morphogenesis
namespace: biological_process
def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "patterning of blood vessels" BROAD [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: part_of GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0001525 ! angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel
relationship: part_of GO:0048514 ! blood vessel morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001981 ! blood vessel

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: has_participant GO:0005874 ! microtubule
relationship: results_in_formation_of_anatomical_entity GO:0097427 ! microtubule bundle

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000970 ! eye
relationship: part_of GO:0150063 ! visual system development
relationship: results_in_development_of UBERON:0000970 ! eye

[Term]
id: GO:0001655
name: urogenital system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004122 ! genitourinary system
relationship: has_part GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0004122 ! genitourinary system
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22178" xsd:anyURI

[Term]
id: GO:0001656
name: metanephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000081 ! metanephros
relationship: results_in_development_of UBERON:0000081 ! metanephros

[Term]
id: GO:0001657
name: ureteric bud development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0072164 ! mesonephric tubule development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000084 ! ureteric bud
relationship: results_in_development_of UBERON:0000084 ! ureteric bud

[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: part_of GO:0060675 ! ureteric bud morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal-level homeostasis

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to intermittent hypoxia" NARROW []
synonym: "response to lowered oxygen tension" EXACT []
synonym: "response to sustained hypoxia" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0036293 ! response to decreased oxygen levels

[Term]
id: GO:0001667
name: ameboidal-type cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
comment: Note that this term refers to a mode of migration rather than to any particular cell type.
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001669
name: acrosomal vesicle
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
synonym: "acrosomal granule" EXACT [GOC:sart]
synonym: "acrosome" EXACT [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule
relationship: part_of CL:0000019 ! sperm

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: part_of CL:0000015 ! male germ cell
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: part_of CL:0000015 ! male germ cell

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: part_of CL:0000021 ! female germ cell
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: part_of CL:0000021 ! female germ cell

[Term]
id: GO:0001675
name: acrosome assembly
namespace: biological_process
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0001669 ! acrosomal vesicle
relationship: part_of GO:0007286 ! spermatid development
relationship: results_in_assembly_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! protein-RNA complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0044207 ! translation initiation ternary complex
relationship: part_of GO:0006413 ! translational initiation
relationship: results_in_assembly_of GO:0044207 ! translation initiation ternary complex

[Term]
id: GO:0001696
name: gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching
relationship: in_taxon NCBITaxon:50557 {all_only="true"} ! Insecta
relationship: only_in_taxon NCBITaxon:50557 ! Insecta

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development
relationship: in_taxon NCBITaxon:32525 {all_only="true"} ! Theria <mammals>
relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>

[Term]
id: GO:0001702
name: gastrulation with mouth forming second
namespace: biological_process
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation
relationship: in_taxon NCBITaxon:33511 {all_only="true"} ! Deuterostomia
relationship: only_in_taxon NCBITaxon:33511 ! Deuterostomia

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000923 ! germ layer
relationship: part_of GO:0007369 ! gastrulation
relationship: results_in_formation_of_anatomical_entity UBERON:0000923 ! germ layer

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000924 ! ectoderm
relationship: part_of GO:0007398 ! ectoderm development
relationship: results_in_formation_of_anatomical_entity UBERON:0000924 ! ectoderm

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000925 ! endoderm
relationship: part_of GO:0007492 ! endoderm development
relationship: results_in_formation_of_anatomical_entity UBERON:0000925 ! endoderm

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000926 ! mesoderm
relationship: part_of GO:0048332 ! mesoderm morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000926 ! mesoderm

[Term]
id: GO:0001743
name: lens placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
synonym: "optic placode formation" RELATED []
is_a: GO:0060788 ! ectodermal placode formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003073 ! lens placode
relationship: part_of GO:0048598 ! embryonic morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003073 ! lens placode

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000018 ! compound eye
relationship: in_taxon NCBITaxon:6656 {all_only="true"} ! Arthropoda
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of GO:0048749 ! compound eye development
relationship: results_in_morphogenesis_of UBERON:0000018 ! compound eye

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:2000019 ! compound eye photoreceptor cell
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: results_in_acquisition_of_features_of CL:2000019 ! compound eye photoreceptor cell

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000287 ! eye photoreceptor cell
relationship: part_of GO:0048592 ! eye morphogenesis
relationship: results_in_acquisition_of_features_of CL:0000287 ! eye photoreceptor cell

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0090497 ! mesenchymal cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000333 ! migratory neural crest cell
relationship: part_of GO:0014032 ! neural crest cell development
relationship: results_in_movement_of CL:0000333 ! migratory neural crest cell

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002329 ! somite
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: part_of GO:0061053 ! somite development
relationship: results_in_formation_of_anatomical_entity UBERON:0002329 ! somite

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]
synonym: "neuron chemotaxis" EXACT []
synonym: "neuron guidance" RELATED []
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000540 ! neuron
relationship: part_of GO:0048699 ! generation of neurons
relationship: results_in_movement_of CL:0000540 ! neuron

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: occurs_in CL:0000542 ! lymphocyte
relationship: occurs_in CL:0000542 ! lymphocyte
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: occurs_in CL:0000084 ! T cell
relationship: occurs_in CL:0000084 ! T cell
relationship: part_of GO:0042110 ! T cell activation

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0032501 ! multicellular organismal process
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24416" xsd:anyURI

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000738 ! leukocyte
relationship: acts_on_population_of CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000084 ! T cell
intersection_of: part_of GO:0042592 ! homeostatic process
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
alt_id: GO:0042032
alt_id: GO:0042089
alt_id: GO:0042107
alt_id: GO:0050663
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "cytokine biosynthetic process" NARROW []
synonym: "cytokine metabolic process" NARROW []
synonym: "cytokine secretion" NARROW []
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interferon secretion" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F]
is_a: GO:0010467 ! gene expression
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19116" xsd:anyURI

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
alt_id: GO:0042035
alt_id: GO:0050707
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine biosynthetic process" NARROW []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine secretion" NARROW []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001816 ! cytokine production
relationship: regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
alt_id: GO:0042036
alt_id: GO:0050710
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "inhibition of cytokine production" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine secretion" NARROW []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001816 ! cytokine production
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
alt_id: GO:0042108
alt_id: GO:0050715
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "positive regulation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001816 ! cytokine production
relationship: positively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0001822
name: kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
synonym: "nephrogenesis" RELATED [GOC:rph]
xref: Wikipedia:Kidney_development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002113 ! kidney
relationship: part_of GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0002113 ! kidney

[Term]
id: GO:0001823
name: mesonephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]
synonym: "Wolffian body development" EXACT [GOC:dph]
is_a: GO:0001822 ! kidney development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000080 ! mesonephros
relationship: results_in_development_of UBERON:0000080 ! mesonephros

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000358 ! blastocyst
relationship: in_taxon NCBITaxon:32525 {all_only="true"} ! Theria <mammals>
relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: results_in_development_of UBERON:0000358 ! blastocyst

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000358 ! blastocyst
relationship: part_of GO:0001824 ! blastocyst development
relationship: results_in_formation_of_anatomical_entity UBERON:0000358 ! blastocyst

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell
relationship: part_of GO:0001825 ! blastocyst formation
relationship: results_in_acquisition_of_features_of CL:2000020 ! inner cell mass cell

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell
relationship: part_of GO:0001825 ! blastocyst formation
relationship: results_in_acquisition_of_features_of CL:1000274 ! trophectodermal cell

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell
relationship: part_of GO:0001829 ! trophectodermal cell differentiation
relationship: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of UBERON:0000358 ! blastocyst
relationship: part_of GO:0001824 ! blastocyst development
relationship: results_in_growth_of UBERON:0000358 ! blastocyst

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:2000020 ! inner cell mass cell
relationship: acts_on_population_of CL:2000020 ! inner cell mass cell
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:1000274 ! trophectodermal cell
relationship: acts_on_population_of CL:1000274 ! trophectodermal cell
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: has_primary_input CL:0000066 ! epithelial cell
intersection_of: results_in_acquisition_of_features_of CL:0008019 ! mesenchymal cell
relationship: has_primary_input CL:0000066 ! epithelial cell

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003075 ! neural plate
relationship: part_of GO:0001840 ! neural plate development
relationship: results_in_morphogenesis_of UBERON:0003075 ! neural plate

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003075 ! neural plate
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: results_in_development_of UBERON:0003075 ! neural plate

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001049 ! neural tube
relationship: part_of GO:0021915 ! neural tube development
relationship: results_in_formation_of_anatomical_entity UBERON:0001049 ! neural tube

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005062 ! neural fold
relationship: part_of GO:0014020 ! primary neural tube formation
relationship: results_in_formation_of_anatomical_entity UBERON:0005062 ! neural fold

[Term]
id: GO:0001878
name: response to yeast
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]
comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast.
is_a: GO:0009620 ! response to fungus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input NCBITaxon:147537 ! Saccharomycotina
relationship: has_primary_input NCBITaxon:147537 ! Saccharomycotina

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000115 ! endothelial cell
relationship: part_of GO:0045446 ! endothelial cell differentiation
relationship: results_in_development_of CL:0000115 ! endothelial cell

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of CL:0000115 ! endothelial cell
relationship: part_of GO:0001885 ! endothelial cell development
relationship: results_in_morphogenesis_of CL:0000115 ! endothelial cell

[Term]
id: GO:0001889
name: liver development
namespace: biological_process
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002107 ! liver
relationship: part_of GO:0061008 ! hepaticobiliary system development
relationship: results_in_development_of UBERON:0002107 ! liver

[Term]
id: GO:0001890
name: placenta development
namespace: biological_process
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001987 ! placenta
relationship: in_taxon NCBITaxon:32525 {all_only="true"} ! Theria <mammals>
relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>
relationship: results_in_development_of UBERON:0001987 ! placenta

[Term]
id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0007106 ! chorionic villus
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development
relationship: results_in_development_of UBERON:0007106 ! chorionic villus

[Term]
id: GO:0001893
name: maternal placenta development
namespace: biological_process
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0060135 ! maternal process involved in female pregnancy
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002450 ! decidua
relationship: part_of GO:0001890 ! placenta development
relationship: results_in_development_of UBERON:0002450 ! decidua

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000115 ! endothelial cell
relationship: acts_on_population_of CL:0000115 ! endothelial cell

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001935 ! endothelial cell proliferation
relationship: regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation
relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation
relationship: positively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002049 ! vasculature
relationship: part_of GO:0072359 ! circulatory system development
relationship: results_in_development_of UBERON:0002049 ! vasculature

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001981 ! blood vessel
relationship: part_of GO:0001568 ! blood vessel development
relationship: results_in_maturation_of UBERON:0001981 ! blood vessel

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion
relationship: positively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
synonym: "intramembranous bone ossification" RELATED [GOC:cjm]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
synonym: "epithelium morphogenesis" EXACT []
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000483 ! epithelium
relationship: part_of GO:0060429 ! epithelium development
relationship: results_in_morphogenesis_of UBERON:0000483 ! epithelium

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0010136 ! epithelial sheet
relationship: results_in_morphogenesis_of UBERON:0010136 ! epithelial sheet

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction

[Term]
id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006814 ! sodium ion transport
relationship: regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation
relationship: positively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation
relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000138 ! chondrocyte
relationship: part_of GO:0051216 ! cartilage development
relationship: results_in_acquisition_of_features_of CL:0000138 ! chondrocyte

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000138 ! chondrocyte
relationship: part_of GO:0002062 ! chondrocyte differentiation
relationship: results_in_development_of CL:0000138 ! chondrocyte

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000066 ! epithelial cell
relationship: part_of GO:0030855 ! epithelial cell differentiation
relationship: results_in_development_of CL:0000066 ! epithelial cell

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000075 ! columnar/cuboidal epithelial cell
relationship: results_in_acquisition_of_features_of CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000075 ! columnar/cuboidal epithelial cell
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation
relationship: results_in_development_of CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000150 ! glandular epithelial cell
relationship: results_in_acquisition_of_features_of CL:0000150 ! glandular epithelial cell

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000150 ! glandular epithelial cell
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation
relationship: results_in_development_of CL:0000150 ! glandular epithelial cell

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: results_in_maturation_of CL:0000075 ! columnar/cuboidal epithelial cell

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000066 ! epithelial cell
relationship: part_of GO:0002064 ! epithelial cell development
relationship: results_in_maturation_of CL:0000066 ! epithelial cell

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000150 ! glandular epithelial cell
relationship: part_of GO:0002068 ! glandular epithelial cell development
relationship: results_in_maturation_of CL:0000150 ! glandular epithelial cell

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003072 ! optic cup
relationship: part_of GO:0060900 ! embryonic camera-type eye formation
relationship: results_in_morphogenesis_of UBERON:0003072 ! optic cup

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0001669 ! acrosomal vesicle
relationship: bounding_layer_of GO:0001669 ! acrosomal vesicle
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation
relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by nervous system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT []
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000965 ! lens of camera-type eye
relationship: part_of GO:0043010 ! camera-type eye development
relationship: results_in_development_of UBERON:0000965 ! lens of camera-type eye

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000965 ! lens of camera-type eye
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: results_in_morphogenesis_of UBERON:0000965 ! lens of camera-type eye

[Term]
id: GO:0002119
name: nematode larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0009850 ! nematode larva
relationship: in_taxon NCBITaxon:33213 {all_only="true"} ! Bilateria
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: results_in_development_of UBERON:0009850 ! nematode larva

[Term]
id: GO:0002164
name: larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
is_a: GO:0007275 ! multicellular organism development
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002176
name: male germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]
is_a: GO:0036093 ! germ cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000015 ! male germ cell
relationship: acts_on_population_of CL:0000015 ! male germ cell
created_by: hjd
creation_date: 2010-11-18T02:35:14Z

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0006952 ! defense response
intersection_of: GO:0006952 ! defense response
intersection_of: has_primary_input NCBITaxon:50557 ! Insecta
relationship: has_primary_input NCBITaxon:50557 ! Insecta

[Term]
id: GO:0002215
name: defense response to nematode
namespace: biological_process
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0006952 ! defense response
intersection_of: GO:0006952 ! defense response
intersection_of: has_primary_input NCBITaxon:6231 ! Nematoda
relationship: has_primary_input NCBITaxon:6231 ! Nematoda

[Term]
id: GO:0002244
name: hematopoietic progenitor cell differentiation
namespace: biological_process
def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0008001 ! hematopoietic precursor cell
relationship: part_of GO:0030097 ! hemopoiesis
relationship: results_in_acquisition_of_features_of CL:0008001 ! hematopoietic precursor cell

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "acquired immune response" EXACT [ISBN:068340007X]
synonym: "immune memory response" EXACT [GOC:add]
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal]
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]
is_a: GO:0002376 ! immune system process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18737" xsd:anyURI

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000542 ! lymphocyte
relationship: acts_on_population_of CL:0000542 ! lymphocyte

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000763 ! myeloid cell
relationship: acts_on_population_of CL:0000763 ! myeloid cell

[Term]
id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0001775 ! cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation
intersection_of: GO:0042118 ! endothelial cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000766 ! myeloid leukocyte
relationship: has_primary_input CL:0000766 ! myeloid leukocyte

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0046649 ! lymphocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0042110 ! T cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation
intersection_of: GO:0030217 ! T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0042098 ! T cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000839 ! myeloid lineage restricted progenitor cell
relationship: results_in_acquisition_of_features_of CL:0000839 ! myeloid lineage restricted progenitor cell

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000838 ! lymphoid lineage restricted progenitor cell
relationship: results_in_acquisition_of_features_of CL:0000838 ! lymphoid lineage restricted progenitor cell

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002374
alt_id: GO:0002375
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "cytokine biosynthetic process involved in immune response" NARROW []
synonym: "cytokine production during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "cytokine secretion involved in immune response" RELATED []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: process_has_causal_agent CL:0000084 ! T cell

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0001816 ! cytokine production
intersection_of: process_has_causal_agent CL:0000451 ! dendritic cell
relationship: process_has_causal_agent CL:0000451 ! dendritic cell

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological process
property_value: RO:0002161 NCBITaxon:4895

[Term]
id: GO:0002384
name: hepatic immune response
namespace: biological_process
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149]
is_a: GO:0002251 ! organ or tissue specific immune response
intersection_of: GO:0006955 ! immune response
intersection_of: occurs_in UBERON:0002107 ! liver
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: occurs_in UBERON:0002107 ! liver
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0065003 ! protein-containing complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0042611 ! MHC protein complex
relationship: results_in_assembly_of GO:0042611 ! MHC protein complex

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0042613 ! MHC class II protein complex
relationship: results_in_assembly_of GO:0042613 ! MHC class II protein complex

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
subset: gocheck_do_not_annotate
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process
is_a: GO:0010467 ! gene expression

[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0002376 ! immune system process
intersection_of: process_has_causal_agent CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: process_has_causal_agent CL:0000738 ! leukocyte

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: process_has_causal_agent CL:0000766 ! myeloid leukocyte
relationship: process_has_causal_agent CL:0000766 ! myeloid leukocyte

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity
intersection_of: GO:0002376 ! immune system process
intersection_of: process_has_causal_agent CL:0000542 ! lymphocyte
relationship: process_has_causal_agent CL:0000542 ! lymphocyte

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149]
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0002376 ! immune system process
intersection_of: process_has_causal_agent CL:0000084 ! T cell
relationship: process_has_causal_agent CL:0000084 ! T cell

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: occurs_in CL:0000084 ! T cell
relationship: occurs_in CL:0000084 ! T cell
relationship: part_of GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation
intersection_of: GO:0019882 ! antigen processing and presentation
intersection_of: occurs_in CL:0000451 ! dendritic cell
relationship: occurs_in CL:0000451 ! dendritic cell

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002405 ! immune system
relationship: results_in_development_of UBERON:0002405 ! immune system

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000738 ! leukocyte
relationship: part_of GO:0030097 ! hemopoiesis
relationship: results_in_acquisition_of_features_of CL:0000738 ! leukocyte

[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
subset: gocheck_do_not_annotate
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000827 ! pro-T cell
relationship: part_of GO:0030217 ! T cell differentiation
relationship: results_in_acquisition_of_features_of CL:0000827 ! pro-T cell

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte
relationship: results_in_acquisition_of_features_of CL:0000766 ! myeloid leukocyte

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019882 ! antigen processing and presentation
relationship: regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019882 ! antigen processing and presentation
relationship: positively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002457 ! T cell antigen processing and presentation
relationship: regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002376 ! immune system process
relationship: regulates GO:0002376 ! immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002376 ! immune system process
relationship: negatively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002376 ! immune system process
relationship: positively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050900 ! leukocyte migration
relationship: regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050900 ! leukocyte migration
relationship: negatively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050900 ! leukocyte migration
relationship: positively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045321 ! leukocyte activation
relationship: regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045321 ! leukocyte activation
relationship: negatively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045321 ! leukocyte activation
relationship: positively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002252 ! immune effector process
relationship: regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002252 ! immune effector process
relationship: negatively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002252 ! immune effector process
relationship: positively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0010468 ! regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002440 ! production of molecular mediator of immune response
relationship: regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010629 ! negative regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0010628 ! positive regulation of gene expression
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002443 ! leukocyte mediated immunity
relationship: regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity
relationship: regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002456 ! T cell mediated immunity
relationship: regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002456 ! T cell mediated immunity
relationship: negatively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002456 ! T cell mediated immunity
relationship: positively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002739
alt_id: GO:0002742
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002367 ! cytokine production involved in immune response
relationship: regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002740
alt_id: GO:0002743
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "negative regulation of cytokine secretion involved in immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
alt_id: GO:0002741
alt_id: GO:0002744
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "positive regulation of cytokine secretion involved in immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002369 ! T cell cytokine production
relationship: regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002369 ! T cell cytokine production
relationship: negatively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002369 ! T cell cytokine production
relationship: positively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002371 ! dendritic cell cytokine production
relationship: regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or a tissue." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:16670 ! peptide

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002790 ! peptide secretion
relationship: regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002790 ! peptide secretion
relationship: negatively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002790 ! peptide secretion
relationship: positively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002250 ! adaptive immune response
relationship: regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002250 ! adaptive immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002250 ! adaptive immune response
relationship: positively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: in_taxon NCBITaxon:7776 {all_only="true"} ! Gnathostomata <vertebrates>
relationship: only_in_taxon NCBITaxon:7776 ! Gnathostomata <vertebrates>
relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009607 ! response to biotic stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002932
name: tendon sheath development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000304 ! tendon sheath
relationship: part_of GO:0035989 ! tendon development
relationship: results_in_development_of UBERON:0000304 ! tendon sheath
created_by: hjd
creation_date: 2012-04-23T02:11:22Z

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "puberty" NARROW [GOC:dph]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: part_of GO:0000003 ! reproduction

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007100 ! primary circulatory organ
relationship: part_of GO:0007507 ! heart development
relationship: results_in_morphogenesis_of UBERON:0007100 ! primary circulatory organ

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: occurs_in UBERON:0001134 ! skeletal muscle tissue
relationship: occurs_in UBERON:0001134 ! skeletal muscle tissue
relationship: part_of GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
subset: goslim_drosophila
subset: goslim_generic
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_chembl
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003014
name: renal system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]
subset: goslim_generic
synonym: "excretory system process" EXACT []
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
alt_id: GO:0010802
def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
subset: goslim_generic
synonym: "respiratory gaseous exchange" EXACT []
is_a: GO:0003008 ! system process
relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003096
name: renal sodium ion transport
namespace: biological_process
def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport
intersection_of: GO:0006814 ! sodium ion transport
intersection_of: occurs_in UBERON:0001008 ! renal system
relationship: occurs_in UBERON:0001008 ! renal system

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000223 ! endodermal cell
intersection_of: has_start_location CL:0000222 ! mesodermal cell
relationship: has_end_location CL:0000223 ! endodermal cell
relationship: has_start_location CL:0000222 ! mesodermal cell
created_by: tb
creation_date: 2009-09-22T03:07:34Z

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000222 ! mesodermal cell
intersection_of: has_start_location CL:0000223 ! endodermal cell
relationship: has_end_location CL:0000222 ! mesodermal cell
relationship: has_start_location CL:0000223 ! endodermal cell
created_by: tb
creation_date: 2009-09-22T03:10:29Z

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004139 ! cardiogenic plate
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004139 ! cardiogenic plate
created_by: tb
creation_date: 2009-09-22T04:12:18Z

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004141 ! heart tube
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development
relationship: part_of GO:0048562 ! embryonic organ morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004141 ! heart tube
created_by: tb
creation_date: 2009-09-22T04:21:17Z

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004141 ! heart tube
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0004141 ! heart tube
created_by: tb
creation_date: 2009-09-22T04:22:34Z

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation
created_by: tb
creation_date: 2009-09-22T04:26:03Z

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development
created_by: tb
creation_date: 2009-09-22T04:29:55Z

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004142 ! outflow tract septum
relationship: part_of GO:0003151 ! outflow tract morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004142 ! outflow tract septum
created_by: tb
creation_date: 2009-09-22T07:51:01Z

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004666 ! interventricular septum membranous part
created_by: tb
creation_date: 2009-09-22T07:51:41Z

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004667 ! interventricular septum muscular part
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004667 ! interventricular septum muscular part
created_by: tb
creation_date: 2009-09-22T07:53:28Z

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004145 ! outflow tract
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004145 ! outflow tract
created_by: tb
creation_date: 2009-09-22T07:59:24Z

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: part_of GO:0003144 ! embryonic heart tube formation
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tb
creation_date: 2009-09-23T10:10:24Z

[Term]
id: GO:0003156
name: regulation of animal organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048645 ! animal organ formation
relationship: regulates GO:0048645 ! animal organ formation
created_by: tb
creation_date: 2009-09-30T11:21:09Z

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002165 ! endocardium
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0002165 ! endocardium
created_by: dph
creation_date: 2009-10-01T12:42:27Z

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001986 ! endothelium
relationship: results_in_development_of UBERON:0001986 ! endothelium
created_by: dph
creation_date: 2009-10-01T12:50:57Z

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001986 ! endothelium
relationship: part_of GO:0003158 ! endothelium development
relationship: results_in_morphogenesis_of UBERON:0001986 ! endothelium
created_by: dph
creation_date: 2009-10-01T01:34:06Z

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002165 ! endocardium
relationship: part_of GO:0003157 ! endocardium development
relationship: results_in_morphogenesis_of UBERON:0002165 ! endocardium
created_by: dph
creation_date: 2009-10-01T01:37:26Z

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002350 ! conducting system of heart
relationship: results_in_development_of UBERON:0002350 ! conducting system of heart
created_by: dph
creation_date: 2009-10-01T01:57:16Z

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002352 ! atrioventricular node
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: results_in_development_of UBERON:0002352 ! atrioventricular node
created_by: dph
creation_date: 2009-10-01T02:05:13Z

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0003228 ! atrial cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002351 ! sinoatrial node
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: results_in_development_of UBERON:0002351 ! sinoatrial node
created_by: dph
creation_date: 2009-10-01T02:06:09Z

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004146 ! His-Purkinje system
relationship: part_of GO:0003161 ! cardiac conduction system development
relationship: results_in_development_of UBERON:0004146 ! His-Purkinje system
created_by: dph
creation_date: 2009-10-01T02:07:12Z

[Term]
id: GO:0003165
name: Purkinje myocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber development" EXACT []
is_a: GO:0003229 ! ventricular cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002354 ! cardiac Purkinje fiber
relationship: part_of GO:0003164 ! His-Purkinje system development
relationship: results_in_development_of UBERON:0002354 ! cardiac Purkinje fiber
created_by: dph
creation_date: 2009-10-01T02:07:50Z

[Term]
id: GO:0003168
name: Purkinje myocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "cardiac Purkinje fiber cell differentiation" EXACT []
is_a: GO:0060932 ! His-Purkinje system cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002068 ! Purkinje myocyte
relationship: part_of GO:0003165 ! Purkinje myocyte development
relationship: results_in_acquisition_of_features_of CL:0002068 ! Purkinje myocyte
created_by: dph
creation_date: 2009-10-01T02:49:54Z

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004148 ! cardiac vein
relationship: results_in_morphogenesis_of UBERON:0004148 ! cardiac vein
created_by: dph
creation_date: 2009-10-08T10:45:41Z

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002062 ! endocardial cushion
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0002062 ! endocardial cushion
created_by: dph
creation_date: 2009-10-08T01:17:43Z

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002062 ! endocardial cushion
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development
relationship: results_in_morphogenesis_of UBERON:0002062 ! endocardial cushion
created_by: dph
creation_date: 2009-10-08T01:43:22Z

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004292 ! cardiac skeleton
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0004292 ! cardiac skeleton
created_by: dph
creation_date: 2009-10-13T09:05:04Z

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004151 ! cardiac chamber
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0004151 ! cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:11:18Z

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004151 ! cardiac chamber
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development
relationship: results_in_morphogenesis_of UBERON:0004151 ! cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:14:51Z

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004151 ! cardiac chamber
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0004151 ! cardiac chamber
created_by: dph
creation_date: 2009-10-13T09:29:13Z

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002082 ! cardiac ventricle
relationship: part_of GO:0003231 ! cardiac ventricle development
relationship: results_in_morphogenesis_of UBERON:0002082 ! cardiac ventricle
created_by: dph
creation_date: 2009-10-13T09:38:44Z

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002081 ! cardiac atrium
relationship: part_of GO:0003230 ! cardiac atrium development
relationship: results_in_morphogenesis_of UBERON:0002081 ! cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:39:44Z

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002081 ! cardiac atrium
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002081 ! cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:44:25Z

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002082 ! cardiac ventricle
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002082 ! cardiac ventricle
created_by: dph
creation_date: 2009-10-13T09:46:27Z

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002079 ! left cardiac atrium
relationship: results_in_morphogenesis_of UBERON:0002079 ! left cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:48:16Z

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002078 ! right cardiac atrium
relationship: results_in_morphogenesis_of UBERON:0002078 ! right cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:49:03Z

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002084 ! heart left ventricle
relationship: results_in_morphogenesis_of UBERON:0002084 ! heart left ventricle
created_by: dph
creation_date: 2009-10-13T09:50:08Z

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002080 ! heart right ventricle
relationship: results_in_morphogenesis_of UBERON:0002080 ! heart right ventricle
created_by: dph
creation_date: 2009-10-13T09:50:57Z

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002079 ! left cardiac atrium
relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002079 ! left cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:52:31Z

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002078 ! right cardiac atrium
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002078 ! right cardiac atrium
created_by: dph
creation_date: 2009-10-13T09:53:12Z

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002084 ! heart left ventricle
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002084 ! heart left ventricle
created_by: dph
creation_date: 2009-10-13T09:54:33Z

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002080 ! heart right ventricle
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002080 ! heart right ventricle
created_by: dph
creation_date: 2009-10-13T09:55:38Z

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003382 ! cardiac muscle of left ventricle
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
relationship: results_in_morphogenesis_of UBERON:0003382 ! cardiac muscle of left ventricle
created_by: dph
creation_date: 2009-10-13T10:18:05Z

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003381 ! cardiac muscle of right ventricle
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
relationship: results_in_morphogenesis_of UBERON:0003381 ! cardiac muscle of right ventricle
created_by: dph
creation_date: 2009-10-13T10:26:33Z

[Term]
id: GO:0003222
name: ventricular trabecula myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
is_a: GO:0061384 ! heart trabecula morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004126 ! trabecular layer of ventricle
relationship: results_in_morphogenesis_of UBERON:0004126 ! trabecular layer of ventricle
created_by: dph
creation_date: 2009-10-13T10:33:00Z

[Term]
id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005064 ! left ventricular trabecular myocardium
relationship: results_in_morphogenesis_of UBERON:0005064 ! left ventricular trabecular myocardium
created_by: dph
creation_date: 2009-10-13T10:45:09Z

[Term]
id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005066 ! right ventricular trabecular myocardium
relationship: results_in_morphogenesis_of UBERON:0005066 ! right ventricular trabecular myocardium
created_by: dph
creation_date: 2009-10-13T10:50:59Z

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium
relationship: results_in_development_of UBERON:0004490 ! cardiac muscle tissue of atrium
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22614" xsd:anyURI
created_by: dph
creation_date: 2009-10-13T10:53:18Z

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: results_in_development_of UBERON:0018649 ! cardiac muscle tissue of ventricle
created_by: dph
creation_date: 2009-10-13T10:56:01Z

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002081 ! cardiac atrium
relationship: results_in_development_of UBERON:0002081 ! cardiac atrium
created_by: dph
creation_date: 2009-10-13T11:02:07Z

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002082 ! cardiac ventricle
relationship: results_in_development_of UBERON:0002082 ! cardiac ventricle
created_by: dph
creation_date: 2009-10-13T11:03:16Z

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002063 ! sinus venosus
relationship: results_in_development_of UBERON:0002063 ! sinus venosus
created_by: dph
creation_date: 2009-10-13T11:12:34Z

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002063 ! sinus venosus
relationship: part_of GO:0003235 ! sinus venosus development
relationship: results_in_morphogenesis_of UBERON:0002063 ! sinus venosus
created_by: dph
creation_date: 2009-10-13T11:16:52Z

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002063 ! sinus venosus
relationship: part_of GO:0003236 ! sinus venosus morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002063 ! sinus venosus
created_by: dph
creation_date: 2009-10-13T11:18:34Z

[Term]
id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003983 ! conus arteriosus
relationship: results_in_development_of UBERON:0003983 ! conus arteriosus
created_by: dph
creation_date: 2009-10-13T11:20:57Z

[Term]
id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003983 ! conus arteriosus
relationship: part_of GO:0003238 ! conus arteriosus development
relationship: results_in_morphogenesis_of UBERON:0003983 ! conus arteriosus
created_by: dph
creation_date: 2009-10-13T11:25:04Z

[Term]
id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003983 ! conus arteriosus
relationship: part_of GO:0003239 ! conus arteriosus morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003983 ! conus arteriosus
created_by: dph
creation_date: 2009-10-13T11:25:47Z

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
intersection_of: GO:0040007 ! growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0060419 ! heart growth
created_by: dph
creation_date: 2009-10-13T11:28:46Z

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
intersection_of: GO:0055017 ! cardiac muscle tissue growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2009-10-13T11:44:21Z

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0006966 ! coronary capillary
relationship: part_of GO:0060419 ! heart growth
relationship: part_of GO:0060976 ! coronary vasculature development
relationship: results_in_growth_of UBERON:0006966 ! coronary capillary
created_by: dph
creation_date: 2009-10-13T11:53:12Z

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-13T02:14:16Z

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0002664 ! cardioblast
relationship: results_in_movement_of CL:0002664 ! cardioblast
created_by: dph
creation_date: 2009-10-15T01:52:25Z

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002062 ! endocardial cushion
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002062 ! endocardial cushion
created_by: dph
creation_date: 2009-10-20T08:53:19Z

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0003272 ! endocardial cushion formation
relationship: part_of GO:0003272 ! endocardial cushion formation
created_by: dph
creation_date: 2009-10-20T09:08:44Z

[Term]
id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in outflow tract morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-20T09:30:01Z

[Term]
id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T09:37:03Z

[Term]
id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart]
synonym: "apoptosis involved in heart morphogenesis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-20T09:40:22Z

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002099 ! cardiac septum
relationship: part_of GO:0003205 ! cardiac chamber development
relationship: results_in_development_of UBERON:0002099 ! cardiac septum
created_by: dph
creation_date: 2009-10-20T09:45:13Z

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002094 ! interventricular septum
relationship: part_of GO:0003231 ! cardiac ventricle development
relationship: results_in_development_of UBERON:0002094 ! interventricular septum
created_by: dph
creation_date: 2009-10-20T10:04:51Z

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002085 ! interatrial septum
relationship: part_of GO:0003230 ! cardiac atrium development
relationship: results_in_development_of UBERON:0002085 ! interatrial septum
created_by: dph
creation_date: 2009-10-20T10:10:38Z

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:2000022 ! cardiac septum cell
relationship: part_of GO:0003279 ! cardiac septum development
relationship: results_in_acquisition_of_features_of CL:2000022 ! cardiac septum cell
created_by: dph
creation_date: 2009-10-20T11:03:46Z

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T09:24:51Z

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T10:33:56Z

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
is_a: GO:0003298 ! physiological muscle hypertrophy
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: part_of GO:0055017 ! cardiac muscle tissue growth
created_by: dph
creation_date: 2009-10-22T10:38:10Z

[Term]
id: GO:0003309
name: type B pancreatic cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772]
synonym: "pancreatic B cell differentiation" EXACT [GOC:mah]
synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell
relationship: part_of GO:0031018 ! endocrine pancreas development
relationship: results_in_acquisition_of_features_of CL:0000169 ! type B pancreatic cell
created_by: dph
creation_date: 2009-10-26T09:27:23Z

[Term]
id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772]
synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell
relationship: part_of GO:0031018 ! endocrine pancreas development
relationship: results_in_acquisition_of_features_of CL:0000171 ! pancreatic A cell
created_by: dph
creation_date: 2009-10-26T09:28:05Z

[Term]
id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772]
synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell
relationship: part_of GO:0031018 ! endocrine pancreas development
relationship: results_in_acquisition_of_features_of CL:0000173 ! pancreatic D cell
created_by: dph
creation_date: 2009-10-26T09:30:27Z

[Term]
id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]
synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell
relationship: part_of GO:0031018 ! endocrine pancreas development
relationship: results_in_acquisition_of_features_of CL:0002275 ! pancreatic PP cell
created_by: dph
creation_date: 2009-10-26T09:32:32Z

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004291 ! heart rudiment
relationship: part_of GO:0035050 ! embryonic heart tube development
relationship: results_in_development_of UBERON:0004291 ! heart rudiment
created_by: dph
creation_date: 2009-10-27T08:32:40Z

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004291 ! heart rudiment
relationship: part_of GO:0003313 ! heart rudiment development
relationship: results_in_morphogenesis_of UBERON:0004291 ! heart rudiment
created_by: dph
creation_date: 2009-10-27T08:38:04Z

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004291 ! heart rudiment
relationship: part_of GO:0003314 ! heart rudiment morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0004291 ! heart rudiment
created_by: dph
creation_date: 2009-10-27T08:43:37Z

[Term]
id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
synonym: "pancreatic alpha cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000171 ! pancreatic A cell
relationship: part_of GO:0003310 ! pancreatic A cell differentiation
relationship: results_in_development_of CL:0000171 ! pancreatic A cell
created_by: dph
creation_date: 2009-11-02T08:13:55Z

[Term]
id: GO:0003323
name: type B pancreatic cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell development" EXACT [GOC:mah]
synonym: "pancreatic beta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000169 ! type B pancreatic cell
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation
relationship: results_in_development_of CL:0000169 ! type B pancreatic cell
created_by: dph
creation_date: 2009-11-02T08:20:11Z

[Term]
id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
synonym: "pancreatic delta cell development" EXACT [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000173 ! pancreatic D cell
relationship: part_of GO:0003311 ! pancreatic D cell differentiation
relationship: results_in_development_of CL:0000173 ! pancreatic D cell
created_by: dph
creation_date: 2009-11-02T08:23:26Z

[Term]
id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0002068 ! glandular epithelial cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0002275 ! pancreatic PP cell
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation
relationship: results_in_development_of CL:0002275 ! pancreatic PP cell
created_by: dph
creation_date: 2009-11-02T08:25:03Z

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "amino acid membrane transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:1903825 ! organic acid transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33709 ! amino acid
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: dph
creation_date: 2009-11-02T02:36:11Z

[Term]
id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
is_a: GO:0072202 ! cell differentiation involved in metanephros development
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis
created_by: dph
creation_date: 2009-11-24T09:29:49Z

[Term]
id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf]
is_a: GO:0060993 ! kidney morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000081 ! metanephros
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_morphogenesis_of UBERON:0000081 ! metanephros
created_by: dph
creation_date: 2009-11-24T09:32:09Z

[Term]
id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:43:04Z

[Term]
id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:46:12Z

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
alt_id: GO:0036142
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliary motility" RELATED []
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "flagellar motility" RELATED []
synonym: "flagellar movement" NARROW [GOC:bf]
synonym: "flagellum movement" NARROW []
synonym: "microtubule-based flagellum movement" EXACT []
is_a: GO:0007018 ! microtubule-based movement
intersection_of: GO:0007018 ! microtubule-based movement
intersection_of: process_has_causal_agent GO:0005874 ! microtubule
intersection_of: results_in_movement_of GO:0005929 ! cilium
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: results_in_movement_of GO:0005929 ! cilium
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI
property_value: RO:0002161 NCBITaxon:3176
property_value: RO:0002161 NCBITaxon:3312
property_value: RO:0002161 NCBITaxon:3378
property_value: RO:0002161 NCBITaxon:3398
property_value: RO:0002161 NCBITaxon:4890
property_value: RO:0002161 NCBITaxon:5782
created_by: dph
creation_date: 2009-11-24T09:56:26Z

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004160 ! proepicardium
relationship: part_of GO:0003343 ! septum transversum development
relationship: results_in_development_of UBERON:0004160 ! proepicardium
created_by: dph
creation_date: 2009-12-01T10:30:17Z

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004161 ! septum transversum
relationship: results_in_development_of UBERON:0004161 ! septum transversum
created_by: dph
creation_date: 2009-12-01T10:40:17Z

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002407 ! pericardium
relationship: part_of GO:0060039 ! pericardium development
relationship: results_in_morphogenesis_of UBERON:0002407 ! pericardium
created_by: dph
creation_date: 2009-12-01T10:46:34Z

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0045446 ! endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010008 ! cardiac endothelial cell
relationship: results_in_acquisition_of_features_of CL:0010008 ! cardiac endothelial cell
created_by: dph
creation_date: 2009-12-01T11:12:05Z

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
alt_id: GO:1900172
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "regulation of flagellum movement" RELATED []
synonym: "regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003341 ! cilium movement
relationship: regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:12:00Z

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
alt_id: GO:1900174
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie]
synonym: "positive regulation of flagellum movement" RELATED []
synonym: "positive regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003341 ! cilium movement
relationship: positively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:16:10Z

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
alt_id: GO:1900173
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "negative regulation of flagellum movement" RELATED []
synonym: "negative regulation of microtubule-based flagellum movement" EXACT []
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003341 ! cilium movement
relationship: negatively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:17:47Z

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0008025 ! noradrenergic neuron
relationship: results_in_acquisition_of_features_of CL:0008025 ! noradrenergic neuron
created_by: dph
creation_date: 2009-12-03T10:34:30Z

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0008025 ! noradrenergic neuron
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation
relationship: results_in_development_of CL:0008025 ! noradrenergic neuron
created_by: dph
creation_date: 2009-12-03T10:38:37Z

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002298 ! brainstem
relationship: results_in_development_of UBERON:0002298 ! brainstem
created_by: dph
creation_date: 2009-12-03T10:47:20Z

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003360 ! brainstem development
created_by: dph
creation_date: 2009-12-03T10:53:30Z

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0001667 ! ameboidal-type cell migration
property_value: RO:0002161 NCBITaxon:4751
created_by: dph
creation_date: 2009-12-08T04:50:41Z

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0001667 ! ameboidal-type cell migration
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T05:42:46Z

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0042074 ! cell migration involved in gastrulation
created_by: dph
creation_date: 2009-12-09T06:54:44Z

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
created_by: dph
creation_date: 2009-12-09T07:10:57Z

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0003382 ! epithelial cell morphogenesis
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-12-09T07:18:53Z

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_maturation_of CL:0000066 ! epithelial cell
relationship: part_of GO:0002064 ! epithelial cell development
relationship: results_in_maturation_of CL:0000066 ! epithelial cell
created_by: dph
creation_date: 2009-12-09T07:21:06Z

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004128 ! optic vesicle
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
relationship: part_of GO:0060900 ! embryonic camera-type eye formation
relationship: results_in_formation_of_anatomical_entity UBERON:0004128 ! optic vesicle
created_by: dph
creation_date: 2009-12-21T01:42:37Z

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004128 ! optic vesicle
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004128 ! optic vesicle
created_by: dph
creation_date: 2009-12-21T01:54:34Z

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003902 ! retinal neural layer
relationship: part_of GO:0060041 ! retina development in camera-type eye
relationship: results_in_development_of UBERON:0003902 ! retinal neural layer
created_by: dph
creation_date: 2009-12-21T02:15:14Z

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T03:04:27Z

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
intersection_of: GO:0002062 ! chondrocyte differentiation
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:39:58Z

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
intersection_of: GO:0090171 ! chondrocyte morphogenesis
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:42:55Z

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0098868 ! bone growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0002513 ! endochondral bone
relationship: results_in_growth_of UBERON:0002513 ! endochondral bone
created_by: dph
creation_date: 2009-12-22T08:52:55Z

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
intersection_of: GO:0002063 ! chondrocyte development
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T12:42:44Z

[Term]
id: GO:0003674
name: gene product or complex activity
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]
def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "molecular function" EXACT []
is_a: BFO:0000015 ! process
disjoint_from: GO:0005575 ! cellular_component
disjoint_from: GO:0008150 ! biological process
property_value: editor_note "This is the same as GO molecular function" xsd:string

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0004518
name: nuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_plant
subset: goslim_yeast
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0004536
name: DNA nuclease activity
namespace: molecular_function
alt_id: GO:0004537
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
synonym: "caspase-activated deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activity" EXACT []
xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40"
xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2"
xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)"
is_a: GO:0004518 ! nuclease activity
is_a: GO:0140097 ! catalytic activity, acting on DNA
relationship: part_of GO:0006259 ! DNA metabolic process

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules.
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
synonym: "carrier" RELATED []
xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion"
xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005279
def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]
synonym: "amine/amide/polyamine channel activity" BROAD []
synonym: "amine/polyamine transmembrane transporter activity" EXACT []
synonym: "amino acid-polyamine transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:32952 ! amine
relationship: has_primary_input CHEBI:32952 ! amine
relationship: part_of GO:0015837 ! amine transport

[Term]
id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles"
is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:1901375 ! acetate ester transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
relationship: has_primary_input CHEBI:15355 ! acetylcholine

[Term]
id: GO:0005310
name: dicarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005312
alt_id: GO:0015365
def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED []
synonym: "dicarboxylate carrier" NARROW []
synonym: "dicarboxylic acid permease activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate"
xref: Reactome:R-HSA-372843 "SLC25A10 mediates exchange of malate and phosphate"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:35692 ! dicarboxylic acid
relationship: has_primary_input CHEBI:35692 ! dicarboxylic acid
relationship: part_of GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0005319
name: lipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]
synonym: "apolipoprotein" RELATED []
synonym: "lipophorin" NARROW []
xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux"
xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx"
xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region"
xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body"
xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane"
xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol"
xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: has_primary_input CHEBI:18059 ! lipid
relationship: has_primary_input CHEBI:18059 ! lipid
relationship: part_of GO:0006869 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! lipid transport

[Term]
id: GO:0005326
name: neurotransmitter transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]
synonym: "neurotransmitter transporter activity" RELATED []
xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline"
xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft"
relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of GO:0006836 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! neurotransmitter transport

[Term]
id: GO:0005342
name: organic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:64709 ! organic acid
relationship: has_primary_input CHEBI:64709 ! organic acid
relationship: part_of GO:1903825 ! organic acid transmembrane transport

[Term]
id: GO:0005355
name: glucose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015579
def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED []
synonym: "glucose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2"
xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen"
is_a: GO:0015149 ! hexose transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:17234 ! glucose
relationship: has_primary_input CHEBI:17234 ! glucose
relationship: part_of GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell or subcellular entity" EXACT []
synonym: "cellular component" EXACT []
synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315]
xref: NIF_Subcellular:sao1337158144
is_a: BFO:0000040 ! material entity
disjoint_from: GO:0008150 ! biological process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17729" xsd:anyURI

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0110165 ! cellular anatomical entity

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
synonym: "fibrinogen" EXACT []
synonym: "fibrinogen alpha chain" NARROW []
synonym: "fibrinogen beta chain" NARROW []
synonym: "fibrinogen gamma chain" NARROW []
is_a: GO:0032991 ! protein-containing complex
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005581
name: collagen trimer
namespace: cellular_component
def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen
is_a: GO:0032991 ! protein-containing complex
relationship: in_taxon NCBITaxon:33208 {all_only="true", source="PMID:12382326"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 {source="PMID:12382326"} ! Metazoa

[Term]
id: GO:0005583
name: fibrillar collagen trimer
namespace: cellular_component
def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0098643 ! banded collagen fibril
disjoint_from: GO:0030936 ! transmembrane collagen trimer
relationship: part_of GO:0098643 ! banded collagen fibril

[Term]
id: GO:0005587
name: collagen type IV trimer
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911]
xref: Wikipedia:Collagen_type_IV
is_a: GO:0098642 ! network-forming collagen trimer
is_a: GO:0098651 ! basement membrane collagen trimer

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
alt_id: GO:0005605
alt_id: GO:0008003
def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]
comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina" RELATED []
synonym: "basement lamina" RELATED []
synonym: "lamina densa" RELATED []
xref: Wikipedia:Basement_membrane
is_a: GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
synonym: "intercellular space" RELATED []
xref: NIF_Subcellular:sao1425028079
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0005622
name: intracellular anatomical structure
namespace: cellular_component
def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "internal to cell" EXACT []
synonym: "intracellular" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17776" xsd:anyURI

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757]
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
disjoint_from: GO:0005737 ! cytoplasm
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
xref: Wikipedia:Nuclear_envelope
is_a: GO:0031967 ! organelle envelope
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
synonym: "nucleus outer envelope" EXACT []
synonym: "perinuclear membrane" EXACT []
xref: NIF_Subcellular:sao1617136075
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005634 ! nucleus
relationship: bounding_layer_of GO:0005634 ! nucleus
relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:Cytoplasm
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of GO:0005622 ! intracellular anatomical structure
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23023" xsd:anyURI

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005773 ! vacuole
relationship: bounding_layer_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732]
is_a: GO:0070013 ! intracellular organelle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
synonym: "Golgi vesicle" RELATED []
synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748]
xref: NIF_Subcellular:sao819927218
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
alt_id: GO:0033279
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046]
synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653]
synonym: "ribosomal RNA" RELATED []
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: PR:000050567 ! protein-containing material entity
relationship: capable_of_part_of GO:0006412 ! translation
relationship: has_part CHEBI:33697 ! ribonucleic acid

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
subset: goslim_metagenomics
synonym: "microtubuli" EXACT []
synonym: "microtubulus" EXACT []
synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196]
xref: NIF_Subcellular:sao1846835077
xref: Wikipedia:Microtubule
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194]
is_a: GO:0005881 ! cytoplasmic microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005930 ! axoneme
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
synonym: "non-spindle-associated astral microtubule" NARROW []
is_a: GO:0005874 ! microtubule
intersection_of: GO:0005874 ! microtubule
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]
synonym: "microfilament" EXACT []
xref: FMA:63850
xref: NIF_Subcellular:sao1588493326
xref: Wikipedia:Actin
is_a: GO:0099513 ! polymeric cytoskeletal fiber
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005887
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645]
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "integral component of plasma membrane" NARROW []
synonym: "integral to plasma membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673]
xref: NIF_Subcellular:sao671419673
xref: Wikipedia:Microvillus
is_a: GO:0098858 ! actin-based cell projection
relationship: has_part GO:0032432 ! actin filament bundle
relationship: part_of CL:0000066 ! epithelial cell
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0005911
name: cell-cell junction
namespace: cellular_component
def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]
synonym: "cell-cell contact region" BROAD []
synonym: "cell-cell contact zone" BROAD []
synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368]
xref: NIF_Subcellular:sao1922892319
is_a: GO:0070161 ! anchoring junction
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22122" xsd:anyURI

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
alt_id: GO:0072372
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
synonym: "eukaryotic flagellum" EXACT []
synonym: "flagellum" RELATED []
synonym: "microtubule-based flagellum" EXACT []
synonym: "primary cilium" NARROW []
xref: FMA:67181
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0120025 ! plasma membrane bounded cell projection
is_a: PR:000050567 ! protein-containing material entity
relationship: has_part GO:0030990 ! intraciliary transport particle
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
property_value: RO:0002161 NCBITaxon:3176
property_value: RO:0002161 NCBITaxon:3312
property_value: RO:0002161 NCBITaxon:3378
property_value: RO:0002161 NCBITaxon:3398
property_value: RO:0002161 NCBITaxon:4890
property_value: RO:0002161 NCBITaxon:5782

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
alt_id: GO:0035085
alt_id: GO:0035086
def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.
subset: goslim_pir
synonym: "ciliary axoneme" EXACT []
synonym: "cilium axoneme" EXACT []
synonym: "flagellar axoneme" EXACT []
synonym: "flagellum axoneme" EXACT []
xref: Wikipedia:Axoneme
is_a: GO:0110165 ! cellular anatomical entity
relationship: has_part GO:0005874 ! microtubule
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0097014 ! ciliary plasm

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "ectoplasm" NARROW []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0071944 ! cell periphery
relationship: part_of GO:0071944 ! cell periphery
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26298" xsd:anyURI

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
alt_id: GO:0044261
alt_id: GO:0044723
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "carbohydrate metabolism" EXACT []
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:16646 ! carbohydrate
relationship: has_primary_input_or_output CHEBI:16646 ! carbohydrate
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22880" xsd:anyURI
created_by: jl
creation_date: 2012-10-23T15:40:34Z

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
alt_id: GO:0044263
def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684]
subset: goslim_pir
synonym: "glycan metabolic process" NARROW []
synonym: "glycan metabolism" NARROW []
synonym: "multicellular organismal polysaccharide metabolic process" NARROW []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:18154 ! polysaccharide
relationship: has_primary_input_or_output CHEBI:18154 ! polysaccharide

[Term]
id: GO:0005977
name: glycogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]
synonym: "glycogen metabolism" EXACT []
is_a: GO:0006112 ! energy reserve metabolic process
is_a: GO:0044042 ! glucan metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:28087 ! glycogen
relationship: has_primary_input_or_output CHEBI:28087 ! glycogen

[Term]
id: GO:0005978
name: glycogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
synonym: "glycogen anabolism" EXACT []
synonym: "glycogen biosynthesis" EXACT []
synonym: "glycogen formation" EXACT []
synonym: "glycogen synthesis" EXACT []
xref: MetaCyc:GLYCOGENSYNTH-PWY
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009250 ! glucan biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:28087 ! glycogen
relationship: has_primary_output CHEBI:28087 ! glycogen

[Term]
id: GO:0005979
name: regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "regulation of glycogen anabolism" EXACT []
synonym: "regulation of glycogen biosynthesis" EXACT []
synonym: "regulation of glycogen formation" EXACT []
synonym: "regulation of glycogen synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005978 ! glycogen biosynthetic process
relationship: regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0005980
name: glycogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]
synonym: "glycogen breakdown" EXACT []
synonym: "glycogen catabolism" EXACT []
synonym: "glycogen degradation" EXACT []
synonym: "glycogenolysis" EXACT [GOC:sl]
xref: MetaCyc:GLYCOCAT-PWY
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009251 ! glucan catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:28087 ! glycogen
relationship: has_primary_input CHEBI:28087 ! glycogen

[Term]
id: GO:0005981
name: regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "regulation of glycogen breakdown" EXACT []
synonym: "regulation of glycogen catabolism" EXACT []
synonym: "regulation of glycogen degradation" EXACT []
synonym: "regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005980 ! glycogen catabolic process
relationship: regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0005996
name: monosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]
synonym: "monosaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044281 ! small molecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35381 ! monosaccharide
relationship: has_primary_input_or_output CHEBI:35381 ! monosaccharide

[Term]
id: GO:0006006
name: glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]
synonym: "cellular glucose metabolic process" EXACT [GOC:vw]
synonym: "glucose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:17234 ! glucose
relationship: has_primary_input_or_output CHEBI:17234 ! glucose

[Term]
id: GO:0006007
name: glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
synonym: "glucose breakdown" EXACT []
synonym: "glucose catabolism" EXACT []
synonym: "glucose degradation" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019320 ! hexose catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:17234 ! glucose
relationship: has_primary_input CHEBI:17234 ! glucose

[Term]
id: GO:0006022
name: aminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:22506 ! aminoglycan
relationship: has_primary_input_or_output CHEBI:22506 ! aminoglycan

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan anabolism" EXACT []
synonym: "aminoglycan biosynthesis" EXACT []
synonym: "aminoglycan formation" EXACT []
synonym: "aminoglycan synthesis" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:22506 ! aminoglycan
relationship: has_primary_output CHEBI:22506 ! aminoglycan

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan anabolism" EXACT []
synonym: "glycosaminoglycan biosynthesis" EXACT []
synonym: "glycosaminoglycan formation" EXACT []
synonym: "glycosaminoglycan synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:18085 ! glycosaminoglycan
relationship: has_primary_output CHEBI:18085 ! glycosaminoglycan

[Term]
id: GO:0006026
name: aminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732]
synonym: "aminoglycan breakdown" EXACT []
synonym: "aminoglycan catabolism" EXACT []
synonym: "aminoglycan degradation" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:22506 ! aminoglycan
relationship: has_primary_input CHEBI:22506 ! aminoglycan

[Term]
id: GO:0006027
name: glycosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan breakdown" EXACT []
synonym: "glycosaminoglycan catabolism" EXACT []
synonym: "glycosaminoglycan degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:18085 ! glycosaminoglycan
relationship: has_primary_input CHEBI:18085 ! glycosaminoglycan

[Term]
id: GO:0006030
name: chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT []
synonym: "chitin metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:17029 ! chitin
relationship: has_primary_input_or_output CHEBI:17029 ! chitin

[Term]
id: GO:0006031
name: chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT []
synonym: "chitin anabolism" EXACT []
synonym: "chitin biosynthesis" EXACT []
synonym: "chitin formation" EXACT []
synonym: "chitin synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:17029 ! chitin
relationship: has_primary_output CHEBI:17029 ! chitin

[Term]
id: GO:0006032
name: chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]
synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT []
synonym: "chitin breakdown" EXACT []
synonym: "chitin catabolism" EXACT []
synonym: "chitin degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:1901072 ! glucosamine-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:17029 ! chitin
relationship: has_primary_input CHEBI:17029 ! chitin

[Term]
id: GO:0006040
name: amino sugar metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
synonym: "amino sugar metabolism" EXACT []
synonym: "aminosaccharide metabolic process" EXACT []
synonym: "aminosaccharide metabolism" EXACT []
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:28963 ! amino sugar
relationship: has_primary_input_or_output CHEBI:28963 ! amino sugar

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: goslim_pir
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:64709 ! organic acid
relationship: has_primary_input_or_output CHEBI:64709 ! organic acid

[Term]
id: GO:0006083
name: acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:30089 ! acetate
relationship: has_primary_input_or_output CHEBI:30089 ! acetate

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006094
name: gluconeogenesis
namespace: biological_process
def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]
synonym: "glucose biosynthesis" EXACT []
synonym: "glucose biosynthetic process" EXACT []
xref: MetaCyc:GLUCONEO-PWY
xref: Wikipedia:Gluconeogenesis
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:17234 ! glucose
relationship: has_primary_output CHEBI:17234 ! glucose

[Term]
id: GO:0006109
name: regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
synonym: "regulation of carbohydrate metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005975 ! carbohydrate metabolic process
relationship: regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0006111
name: regulation of gluconeogenesis
namespace: biological_process
alt_id: GO:0090526
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators]
synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED []
synonym: "regulation of glucose biosynthesis" BROAD []
synonym: "regulation of glucose biosynthetic process" BROAD []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006094 ! gluconeogenesis
relationship: regulates GO:0006094 ! gluconeogenesis
created_by: tb
creation_date: 2013-01-18T12:47:43Z

[Term]
id: GO:0006112
name: energy reserve metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]
subset: goslim_pir
synonym: "energy reserve metabolism" EXACT []
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006139
name: nucleobase-containing compound metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_primary_input_or_output CHEBI:61120 ! nucleobase-containing molecular entity

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
synonym: "cellular DNA metabolism" EXACT []
synonym: "DNA metabolism" EXACT []
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid
relationship: has_primary_input_or_output CHEBI:16991 ! deoxyribonucleic acid

[Term]
id: GO:0006308
name: DNA catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]
synonym: "DNA breakdown" EXACT []
synonym: "DNA catabolism" EXACT []
synonym: "DNA degradation" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
relationship: has_part GO:0004536 ! DNA nuclease activity
relationship: has_primary_input CHEBI:16991 ! deoxyribonucleic acid

[Term]
id: GO:0006309
name: apoptotic DNA fragmentation
namespace: biological_process
alt_id: GO:0008178
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis]
synonym: "DNA catabolic process during apoptosis" EXACT []
synonym: "DNA catabolism during apoptosis" EXACT []
synonym: "DNA fragmentation" BROAD []
synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb]
synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT []
is_a: GO:0006308 ! DNA catabolic process
intersection_of: GO:0006308 ! DNA catabolic process
intersection_of: part_of GO:0030262 ! apoptotic nuclear changes
relationship: part_of GO:0030262 ! apoptotic nuclear changes
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24396" xsd:anyURI

[Term]
id: GO:0006325
name: chromatin organization
namespace: biological_process
alt_id: GO:0006333
alt_id: GO:0006336
alt_id: GO:0016568
alt_id: GO:0031497
alt_id: GO:0034724
def: "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "chromatin assembly" NARROW []
synonym: "chromatin assembly or disassembly" RELATED []
synonym: "chromatin assembly/disassembly" RELATED []
synonym: "chromatin maintenance" BROAD []
synonym: "chromatin modification" RELATED []
synonym: "chromatin organisation" EXACT [GOC:mah]
synonym: "DNA replication-independent chromatin assembly" NARROW []
synonym: "DNA replication-independent chromatin organization" NARROW []
synonym: "DNA replication-independent nucleosome organisation" NARROW []
synonym: "DNA replication-independent nuclesome assembly" NARROW []
synonym: "establishment of chromatin architecture" EXACT [GOC:mah]
synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah]
synonym: "transcription-coupled nucleosome assembly" NARROW []
is_a: GO:0071824 ! protein-DNA complex organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0000785 ! chromatin
relationship: results_in_organization_of GO:0000785 ! chromatin
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22130" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23549" xsd:anyURI

[Term]
id: GO:0006401
name: RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_yeast
synonym: "RNA breakdown" EXACT []
synonym: "RNA catabolism" EXACT []
synonym: "RNA degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0034655 ! nucleobase-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid
relationship: has_primary_input CHEBI:33697 ! ribonucleic acid

[Term]
id: GO:0006403
name: RNA localization
namespace: biological_process
def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "establishment and maintenance of RNA localization" EXACT []
synonym: "RNA localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT []
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Wikipedia:Translation_(genetics)
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043043 ! peptide biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:16541 ! protein polypeptide chain
intersection_of: part_of GO:0010467 ! gene expression
relationship: ends_with GO:0006415 ! translational termination
relationship: has_part GO:0006414 ! translational elongation
relationship: has_primary_output CHEBI:16541 ! protein polypeptide chain
relationship: part_of GO:0010467 ! gene expression
relationship: starts_with GO:0006413 ! translational initiation

[Term]
id: GO:0006413
name: translational initiation
namespace: biological_process
alt_id: GO:0006440
alt_id: GO:0006454
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
subset: goslim_yeast
synonym: "biopolymerisation" BROAD []
synonym: "biopolymerization" BROAD []
synonym: "protein synthesis initiation" BROAD []
synonym: "translation initiation" EXACT []
is_a: GO:0044237 ! cellular metabolic process
relationship: part_of GO:0006412 ! translation
relationship: starts_with GO:0001677 ! formation of translation initiation ternary complex

[Term]
id: GO:0006414
name: translational elongation
namespace: biological_process
alt_id: GO:0006442
alt_id: GO:0006455
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
subset: goslim_yeast
synonym: "protein synthesis elongation" BROAD []
synonym: "translation elongation" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006415
name: translational termination
namespace: biological_process
alt_id: GO:0006443
alt_id: GO:0006456
def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
synonym: "protein synthesis termination" BROAD []
synonym: "translation termination" EXACT []
synonym: "translational complex disassembly" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006417
name: regulation of translation
namespace: biological_process
alt_id: GO:0006445
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
subset: goslim_yeast
synonym: "regulation of protein anabolism" EXACT []
synonym: "regulation of protein biosynthesis" EXACT []
synonym: "regulation of protein formation" EXACT []
synonym: "regulation of protein synthesis" EXACT []
is_a: GO:0010608 ! post-transcriptional regulation of gene expression
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006412 ! translation
relationship: regulates GO:0006412 ! translation

[Term]
id: GO:0006446
name: regulation of translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006413 ! translational initiation
relationship: regulates GO:0006413 ! translational initiation

[Term]
id: GO:0006448
name: regulation of translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006414 ! translational elongation
relationship: regulates GO:0006414 ! translational elongation

[Term]
id: GO:0006449
name: regulation of translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006415 ! translational termination
relationship: regulates GO:0006415 ! translational termination

[Term]
id: GO:0006516
name: glycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycoprotein breakdown" EXACT []
synonym: "glycoprotein catabolism" EXACT []
synonym: "glycoprotein degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:17089 ! glycoprotein
relationship: has_primary_input CHEBI:17089 ! glycoprotein

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]
subset: goslim_pir
synonym: "peptide metabolism" EXACT []
is_a: GO:0043603 ! amide metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:16670 ! peptide
relationship: has_primary_input_or_output CHEBI:16670 ! peptide

[Term]
id: GO:0006520
name: amino acid metabolic process
namespace: biological_process
alt_id: GO:0006519
def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "amino acid and derivative metabolism" RELATED []
synonym: "cellular amino acid and derivative metabolic process" RELATED []
synonym: "cellular amino acid metabolic process" EXACT []
synonym: "cellular amino acid metabolism" EXACT []
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35238 ! amino acid zwitterion
relationship: has_primary_input_or_output CHEBI:35238 ! amino acid zwitterion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI

[Term]
id: GO:0006521
name: regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators]
synonym: "regulation of amino acid metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006520 ! amino acid metabolic process
relationship: regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0006576
name: biogenic amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine metabolism" EXACT []
synonym: "cellular biogenic amine metabolic process" EXACT []
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0006581
name: acetylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
relationship: has_primary_input CHEBI:15355 ! acetylcholine

[Term]
id: GO:0006584
name: catecholamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine metabolism" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009712 ! catechol-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33567 ! catecholamine
relationship: has_primary_input_or_output CHEBI:33567 ! catecholamine

[Term]
id: GO:0006586
name: indolalkylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators]
synonym: "indolalkylamine metabolism" EXACT []
synonym: "indolamine metabolic process" BROAD []
synonym: "indolamine metabolism" BROAD []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:38631 ! aminoalkylindole
relationship: has_primary_input_or_output CHEBI:38631 ! aminoalkylindole

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "lipid metabolism" EXACT []
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:18059 ! lipid
relationship: has_primary_input_or_output CHEBI:18059 ! lipid

[Term]
id: GO:0006694
name: steroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
synonym: "steroid anabolism" EXACT []
synonym: "steroid biosynthesis" EXACT []
synonym: "steroid formation" EXACT []
synonym: "steroid synthesis" EXACT []
synonym: "steroidogenesis" EXACT []
xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:35341 ! steroid
relationship: has_primary_output CHEBI:35341 ! steroid

[Term]
id: GO:0006699
name: bile acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid anabolism" EXACT []
synonym: "bile acid biosynthesis" EXACT []
synonym: "bile acid formation" EXACT []
synonym: "bile acid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:36235 ! bile acid anion
relationship: has_primary_output CHEBI:36235 ! bile acid anion

[Term]
id: GO:0006706
name: steroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]
synonym: "steroid breakdown" EXACT []
synonym: "steroid catabolism" EXACT []
synonym: "steroid degradation" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:35341 ! steroid
relationship: has_primary_input CHEBI:35341 ! steroid

[Term]
id: GO:0006725
name: cellular aromatic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
synonym: "aromatic compound metabolism" EXACT []
synonym: "aromatic hydrocarbon metabolic process" NARROW []
synonym: "aromatic hydrocarbon metabolism" NARROW []
is_a: GO:0044237 ! cellular metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33655 ! aromatic compound
relationship: has_primary_input_or_output CHEBI:33655 ! aromatic compound

[Term]
id: GO:0006790
name: sulfur compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "sulfur metabolism" EXACT []
synonym: "sulphur metabolic process" EXACT []
synonym: "sulphur metabolism" EXACT []
xref: Wikipedia:Sulfur_metabolism
is_a: GO:0044237 ! cellular metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:26835 ! sulfur molecular entity
relationship: has_primary_input_or_output CHEBI:26835 ! sulfur molecular entity

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai]
subset: goslim_pir
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:26082 ! phosphorus molecular entity
relationship: has_primary_input_or_output CHEBI:26082 ! phosphorus molecular entity

[Term]
id: GO:0006796
name: phosphate-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
synonym: "phosphate metabolic process" RELATED []
synonym: "phosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:26020 ! phosphate
relationship: has_primary_input_or_output CHEBI:26020 ! phosphate

[Term]
id: GO:0006807
name: nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]
subset: gocheck_do_not_annotate
subset: goslim_metagenomics
subset: goslim_pir
synonym: "nitrogen compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:51143 ! nitrogen molecular entity
relationship: has_primary_input_or_output CHEBI:51143 ! nitrogen molecular entity
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
alt_id: GO:0044765
def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
synonym: "single-organism transport" RELATED []
is_a: GO:0051234 ! establishment of localization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20292" xsd:anyURI
created_by: jl
creation_date: 2012-12-13T16:25:32Z

[Term]
id: GO:0006811
name: monoatomic ion transport
namespace: biological_process
def: "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "ion transport" BROAD []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:24867 ! monoatomic ion
relationship: has_primary_input CHEBI:24867 ! monoatomic ion

[Term]
id: GO:0006812
name: monoatomic cation transport
namespace: biological_process
alt_id: GO:0006819
alt_id: GO:0015674
alt_id: GO:0072512
def: "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]
synonym: "cation transport" BROAD []
synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah]
synonym: "trivalent inorganic cation transport" NARROW []
is_a: GO:0006811 ! monoatomic ion transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation
relationship: has_primary_input CHEBI:23906 ! monoatomic cation

[Term]
id: GO:0006814
name: sodium ion transport
namespace: biological_process
alt_id: GO:0006834
alt_id: GO:0016974
def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "sodium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
synonym: "sodium:calcium exchange" NARROW []
synonym: "sodium:solute transport" NARROW []
is_a: GO:0030001 ! metal ion transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:29101 ! sodium(1+)
relationship: has_primary_input CHEBI:29101 ! sodium(1+)

[Term]
id: GO:0006817
name: phosphate ion transport
namespace: biological_process
def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "phosphate transport" RELATED []
is_a: GO:0015698 ! inorganic anion transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:35780 ! phosphate ion
relationship: has_primary_input CHEBI:35780 ! phosphate ion

[Term]
id: GO:0006835
name: dicarboxylic acid transport
namespace: biological_process
alt_id: GO:0006841
def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sodium:dicarboxylate transport" RELATED []
is_a: GO:0046942 ! carboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:35693 ! dicarboxylic acid anion
relationship: has_primary_input CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
is_a: GO:0006810 ! transport
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+)
relationship: has_primary_input CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0006846
name: acetate transport
namespace: biological_process
def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:30089 ! acetate
relationship: has_primary_input CHEBI:30089 ! acetate

[Term]
id: GO:0006847
name: plasma membrane acetate transport
namespace: biological_process
def: "The directed movement of acetate across a plasma membrane." [GOC:ai]
is_a: GO:0035433 ! acetate transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:30089 ! acetate
intersection_of: results_in_transport_across GO:0005886 ! plasma membrane
relationship: results_in_transport_across GO:0005886 ! plasma membrane

[Term]
id: GO:0006858
name: extracellular transport
namespace: biological_process
def: "The transport of substances that occurs outside cells." [GOC:go_curators]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region

[Term]
id: GO:0006860
name: extracellular amino acid transport
namespace: biological_process
def: "The directed extracellular movement of amino acids." [GOC:ai]
is_a: GO:0006858 ! extracellular transport
is_a: GO:0006865 ! amino acid transport
intersection_of: GO:0006865 ! amino acid transport
intersection_of: occurs_in GO:0005576 ! extracellular region

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0015849 ! organic acid transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33709 ! amino acid
relationship: has_primary_input CHEBI:33709 ! amino acid

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18059 ! lipid
relationship: has_primary_input CHEBI:18059 ! lipid
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0006886
name: intracellular protein transport
namespace: biological_process
alt_id: GO:0032779
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "copper-induced intracellular protein transport" RELATED [GOC:al]
is_a: GO:0015031 ! protein transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0006887
name: exocytosis
namespace: biological_process
alt_id: GO:0016194
alt_id: GO:0016195
def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]
subset: goslim_yeast
synonym: "nonselective vesicle exocytosis" RELATED []
synonym: "vesicle exocytosis" EXACT []
xref: Wikipedia:Exocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0006810 ! transport
intersection_of: process_has_causal_agent GO:0070382 ! exocytic vesicle
relationship: has_part GO:0099500 ! vesicle fusion to plasma membrane
relationship: process_has_causal_agent GO:0070382 ! exocytic vesicle

[Term]
id: GO:0006892
name: post-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
synonym: "post-Golgi transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006893
name: Golgi to plasma membrane transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]
synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: has_target_end_location GO:0005886 ! plasma membrane
intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus
relationship: has_target_start_location GO:0005794 ! Golgi apparatus

[Term]
id: GO:0006896
name: Golgi to vacuole transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
synonym: "Golgi to vacuole vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007034 ! vacuolar transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: has_target_end_location GO:0005773 ! vacuole
intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
relationship: has_target_end_location GO:0005773 ! vacuole
relationship: has_target_start_location GO:0005794 ! Golgi apparatus

[Term]
id: GO:0006897
name: endocytosis
namespace: biological_process
alt_id: GO:0016193
alt_id: GO:0016196
alt_id: GO:0098701
def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]
subset: goslim_yeast
synonym: "endocytic import into cell" EXACT []
synonym: "nonselective vesicle endocytosis" RELATED []
synonym: "plasma membrane invagination" NARROW []
synonym: "vesicle endocytosis" EXACT []
xref: Wikipedia:Endocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0098657 ! import into cell
relationship: has_part GO:0006900 ! vesicle budding from membrane
relationship: has_part GO:0010324 ! membrane invagination
relationship: has_target_end_location GO:0031410 ! cytoplasmic vesicle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25268" xsd:anyURI

[Term]
id: GO:0006900
name: vesicle budding from membrane
namespace: biological_process
alt_id: GO:0006902
alt_id: GO:1902591
def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]
synonym: "membrane evagination" EXACT []
synonym: "nonselective vesicle assembly" RELATED []
synonym: "single organism membrane budding" RELATED [GOC:TermGenie]
synonym: "single-organism membrane budding" RELATED []
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle budding" RELATED []
synonym: "vesicle formation" EXACT []
is_a: GO:0016050 ! vesicle organization
is_a: GO:0061024 ! membrane organization
relationship: part_of GO:0016192 ! vesicle-mediated transport
created_by: jl
creation_date: 2013-12-19T15:26:17Z

[Term]
id: GO:0006903
name: vesicle targeting
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0016192 ! vesicle-mediated transport
relationship: part_of GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0006906
name: vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0012506 ! vesicle membrane
relationship: part_of GO:0016192 ! vesicle-mediated transport
relationship: results_in_fusion_of GO:0012506 ! vesicle membrane

[Term]
id: GO:0006909
name: phagocytosis
namespace: biological_process
def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]
xref: Wikipedia:Phagocytosis
is_a: GO:0006897 ! endocytosis
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0006915
name: apoptotic process
namespace: biological_process
alt_id: GO:0006917
alt_id: GO:0008632
def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
synonym: "activation of apoptosis" NARROW []
synonym: "apoptosis" NARROW []
synonym: "apoptosis activator activity" RELATED []
synonym: "apoptosis signaling" NARROW []
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "caspase-dependent programmed cell death" RELATED []
synonym: "cell suicide" BROAD []
synonym: "cellular suicide" BROAD []
synonym: "commitment to apoptosis" RELATED []
synonym: "induction of apoptosis" RELATED []
synonym: "induction of apoptosis by p53" RELATED []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death
relationship: ends_with GO:0097194 ! execution phase of apoptosis
relationship: in_taxon NCBITaxon:33154 {all_only="true"} ! Opisthokonta
relationship: only_in_taxon NCBITaxon:33154 ! Opisthokonta
relationship: starts_with GO:0097190 ! apoptotic signaling pathway
property_value: RO:0002161 NCBITaxon:2
property_value: RO:0002161 NCBITaxon:4896

[Term]
id: GO:0006921
name: cellular component disassembly involved in execution phase of apoptosis
namespace: biological_process
def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb]
synonym: "cellular component disassembly involved in apoptosis" NARROW []
synonym: "cellular component disassembly involved in apoptotic process" BROAD []
synonym: "disassembly of cell structures" BROAD []
is_a: GO:0022411 ! cellular component disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: part_of GO:0097194 ! execution phase of apoptosis
relationship: part_of GO:0097194 ! execution phase of apoptosis

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Muscle_contraction
is_a: GO:0003012 ! muscle system process
relationship: occurs_in UBERON:0002385 ! muscle tissue

[Term]
id: GO:0006937
name: regulation of muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006936 ! muscle contraction
relationship: regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0006939
name: smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "visceral muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: occurs_in UBERON:0001135 ! smooth muscle tissue
relationship: occurs_in UBERON:0001135 ! smooth muscle tissue

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006939 ! smooth muscle contraction
relationship: regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0006941
name: striated muscle contraction
namespace: biological_process
def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732]
synonym: "sarcomeric muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction
relationship: occurs_in UBERON:0002036 ! striated muscle tissue

[Term]
id: GO:0006942
name: regulation of striated muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006941 ! striated muscle contraction
relationship: regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity CL:0000228 ! multinucleate cell
relationship: results_in_formation_of_anatomical_entity CL:0000228 ! multinucleate cell

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
namespace: biological_process
alt_id: GO:0002217
alt_id: GO:0042829
def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
synonym: "antimicrobial peptide activity" RELATED []
synonym: "defence response" EXACT []
synonym: "defense/immunity protein activity" RELATED []
synonym: "physiological defense response" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006954
name: inflammatory response
namespace: biological_process
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732]
subset: goslim_generic
synonym: "inflammation" BROAD []
xref: Wikipedia:Inflammation
is_a: GO:0006952 ! defense response
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: GO:0006955
name: immune response
namespace: biological_process
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]
subset: goslim_drosophila
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
alt_id: GO:1902589
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
synonym: "organelle organisation" EXACT []
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
synonym: "single organism organelle organization" EXACT [GOC:TermGenie]
synonym: "single-organism organelle organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0043226 ! organelle
relationship: results_in_organization_of GO:0043226 ! organelle
created_by: jl
creation_date: 2013-12-19T15:25:51Z

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT []
synonym: "nuclear organization" EXACT []
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005634 ! nucleus
relationship: results_in_organization_of GO:0005634 ! nucleus

[Term]
id: GO:0006998
name: nuclear envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
synonym: "nuclear envelope organisation" EXACT [GOC:mah]
synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005635 ! nuclear envelope
relationship: part_of GO:0006997 ! nucleus organization
relationship: part_of GO:0010256 ! endomembrane system organization
relationship: results_in_organization_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0007000
name: nucleolus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]
synonym: "nucleolus organisation" EXACT []
synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005730 ! nucleolus
relationship: results_in_organization_of GO:0005730 ! nucleolus

[Term]
id: GO:0007009
name: plasma membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
synonym: "plasma membrane organisation" EXACT []
synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005886 ! plasma membrane
relationship: part_of GO:0010256 ! endomembrane system organization
relationship: results_in_organization_of GO:0005886 ! plasma membrane

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT []
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005856 ! cytoskeleton
relationship: results_in_organization_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0007015
name: actin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
synonym: "actin filament organisation" EXACT []
synonym: "regulation of actin filament localization" NARROW []
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005884 ! actin filament
relationship: part_of GO:0030036 ! actin cytoskeleton organization
relationship: results_in_organization_of GO:0005884 ! actin filament

[Term]
id: GO:0007017
name: microtubule-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
subset: goslim_chembl
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: process_has_causal_agent GO:0005874 ! microtubule
relationship: process_has_causal_agent GO:0005874 ! microtubule
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI

[Term]
id: GO:0007018
name: microtubule-based movement
namespace: biological_process
def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
subset: goslim_drosophila
subset: goslim_generic
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0007019
name: microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule depolymerization during nuclear congression" NARROW []
synonym: "microtubule disassembly" EXACT []
synonym: "microtubule shortening" EXACT []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005874 ! microtubule
relationship: results_in_disassembly_of GO:0005874 ! microtubule

[Term]
id: GO:0007020
name: microtubule nucleation
namespace: biological_process
def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]
xref: Wikipedia:Microtubule_nucleation
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0046785 ! microtubule polymerization

[Term]
id: GO:0007026
name: negative regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
synonym: "down regulation of microtubule depolymerization" EXACT []
synonym: "down-regulation of microtubule depolymerization" EXACT []
synonym: "downregulation of microtubule depolymerization" EXACT []
synonym: "inhibition of microtubule depolymerization" NARROW []
synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of microtubule disassembly" EXACT []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901880 ! negative regulation of protein depolymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007019 ! microtubule depolymerization
relationship: negatively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0007027
name: negative regulation of axonemal microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah]
synonym: "axonemal microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization
relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "cytoplasm organisation" EXACT []
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005737 ! cytoplasm
relationship: results_in_organization_of GO:0005737 ! cytoplasm

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi apparatus organization" EXACT []
synonym: "Golgi organisation" EXACT []
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0010256 ! endomembrane system organization
relationship: results_in_organization_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT []
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005773 ! vacuole
relationship: results_in_organization_of GO:0005773 ! vacuole

[Term]
id: GO:0007034
name: vacuolar transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai]
subset: goslim_chembl
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: results_in_transport_to_from_or_in GO:0005773 ! vacuole
relationship: results_in_transport_to_from_or_in GO:0005773 ! vacuole

[Term]
id: GO:0007039
name: protein catabolic process in the vacuole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw]
synonym: "vacuolar protein breakdown" RELATED []
synonym: "vacuolar protein catabolic process" RELATED []
synonym: "vacuolar protein catabolism" RELATED []
synonym: "vacuolar protein degradation" RELATED []
is_a: GO:0030163 ! protein catabolic process
intersection_of: GO:0030163 ! protein catabolic process
intersection_of: occurs_in GO:0005773 ! vacuole
relationship: occurs_in GO:0005773 ! vacuole

[Term]
id: GO:0007043
name: cell-cell junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
synonym: "intercellular junction assembly" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0045216 ! cell-cell junction organization
intersection_of: GO:0034329 ! cell junction assembly
intersection_of: results_in_assembly_of GO:0005911 ! cell-cell junction
relationship: results_in_assembly_of GO:0005911 ! cell-cell junction

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle]
subset: gocheck_do_not_manually_annotate
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_pir
subset: goslim_plant
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0007076
name: mitotic chromosome condensation
namespace: biological_process
def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007077
name: mitotic nuclear membrane disassembly
namespace: biological_process
def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252]
synonym: "local NEB" BROAD []
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" RELATED []
synonym: "mitotic nuclear envelope degradation" RELATED []
synonym: "mitotic nuclear envelope disassembly" RELATED []
synonym: "NEB" BROAD []
synonym: "nuclear envelope breakdown" BROAD []
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007088
name: regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "regulation of mitosis" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0140014 ! mitotic nuclear division
relationship: regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0007097
name: nuclear migration
namespace: biological_process
alt_id: GO:0040023
def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
synonym: "establishment of cell nucleus localization" RELATED []
synonym: "establishment of localization of nucleus" RELATED []
synonym: "establishment of nucleus localisation" RELATED [GOC:mah]
synonym: "establishment of nucleus localization" RELATED []
synonym: "establishment of position of nucleus" EXACT []
synonym: "nuclear movement" EXACT []
synonym: "nuclear positioning" EXACT []
synonym: "nucleus migration" EXACT []
synonym: "nucleus positioning" EXACT []
synonym: "positioning of nucleus" EXACT []
is_a: GO:0046907 ! intracellular transport
is_a: GO:0051647 ! nucleus localization
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input GO:0005634 ! nucleus

[Term]
id: GO:0007113
name: endomitotic cell cycle
namespace: biological_process
def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins.
synonym: "endomitosis" RELATED []
xref: Wikipedia:Mitosis#Endomitosis
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007135
name: meiosis II
namespace: biological_process
def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684]
synonym: "meiosis II nuclear division" EXACT []
xref: Wikipedia:Meiosis#Meiosis_II
is_a: GO:0061983 ! meiosis II cell cycle process
is_a: GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0007140
name: male meiotic nuclear division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw]
synonym: "male meiosis" RELATED []
synonym: "male nuclear division" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0140013 ! meiotic nuclear division
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0048232 ! male gamete generation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0048232 ! male gamete generation
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0007142
name: male meiosis II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah]
synonym: "male meiosis II nuclear division" EXACT []
is_a: GO:0007135 ! meiosis II
is_a: GO:0007140 ! male meiotic nuclear division
intersection_of: GO:0007135 ! meiosis II
intersection_of: part_of GO:0048232 ! male gamete generation
intersection_of: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0007143
name: female meiotic nuclear division
namespace: biological_process
def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw]
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'.
synonym: "female meiosis" BROAD []
synonym: "female meiotic division" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0140013 ! meiotic nuclear division
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0007292 ! female gamete generation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007292 ! female gamete generation
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0007147
name: female meiosis II
namespace: biological_process
def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah]
synonym: "female meiosis II nuclear division" EXACT []
is_a: GO:0007135 ! meiosis II
is_a: GO:0007143 ! female meiotic nuclear division
intersection_of: GO:0007135 ! meiosis II
intersection_of: part_of GO:0007292 ! female gamete generation
intersection_of: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_pir
subset: goslim_plant
xref: Wikipedia:Cell_signaling
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
alt_id: GO:0098602
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell adhesion molecule activity" RELATED []
synonym: "single organism cell adhesion" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0009987 ! cellular process
created_by: dos
creation_date: 2014-04-15T15:59:10Z

[Term]
id: GO:0007159
name: leukocyte cell-cell adhesion
namespace: biological_process
def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators]
synonym: "leukocyte adhesion" EXACT []
synonym: "leukocyte cell adhesion" EXACT []
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: has_participant CL:0000738 ! leukocyte
relationship: has_participant CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "cell adhesion receptor inhibitor activity" RELATED []
synonym: "down regulation of cell adhesion" EXACT []
synonym: "down-regulation of cell adhesion" EXACT []
synonym: "downregulation of cell adhesion" EXACT []
synonym: "inhibition of cell adhesion" NARROW []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007155 ! cell adhesion
relationship: negatively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0007163
name: establishment or maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030012
alt_id: GO:0030467
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cell polarity" RELATED [GOC:mah, GOC:vw]
synonym: "establishment and/or maintenance of cell polarity" RELATED []
synonym: "establishment and/or maintenance of cell polarization" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
alt_id: GO:0023014
alt_id: GO:0023015
alt_id: GO:0023016
alt_id: GO:0023033
alt_id: GO:0023045
def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "signal transduction by cis-phosphorylation" NARROW []
synonym: "signal transduction by conformational transition" NARROW []
synonym: "signal transduction by protein phosphorylation" NARROW []
synonym: "signal transduction by trans-phosphorylation" NARROW []
synonym: "signaling cascade" NARROW []
synonym: "signaling pathway" RELATED []
synonym: "signalling cascade" NARROW []
synonym: "signalling pathway" RELATED [GOC:mah]
xref: Wikipedia:Signal_transduction
is_a: GO:0009987 ! cellular process
is_a: GO:0050794 ! regulation of cellular process
relationship: part_of GO:0007154 ! cell communication
relationship: part_of GO:0023052 ! signaling
relationship: part_of GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0007267
name: cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]
subset: goslim_chembl
subset: goslim_plant
synonym: "cell-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023052 ! signaling

[Term]
id: GO:0007268
name: chemical synaptic transmission
namespace: biological_process
def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]
subset: goslim_synapse
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "signal transmission across a synapse" BROAD []
synonym: "synaptic transmission" BROAD []
xref: Wikipedia:Neurotransmission
is_a: GO:0098916 ! anterograde trans-synaptic signaling
relationship: has_participant GO:0045202 ! synapse

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
alt_id: GO:0010554
def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph]
comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
subset: goslim_synapse
synonym: "neurotransmitter release" EXACT []
synonym: "neurotransmitter secretory pathway" EXACT []
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099643 ! signal release from synapse
relationship: occurs_in GO:0098793 ! presynapse

[Term]
id: GO:0007271
name: synaptic transmission, cholinergic
namespace: biological_process
def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic]
synonym: "cholinergic synaptic transmission" EXACT []
is_a: GO:0007268 ! chemical synaptic transmission
relationship: has_participant CHEBI:15355 ! acetylcholine

[Term]
id: GO:0007274
name: neuromuscular synaptic transmission
namespace: biological_process
def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]
is_a: GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0007275
name: multicellular organism development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_developmental_progression_of UBERON:0000468 ! multicellular organism
relationship: results_in_developmental_progression_of UBERON:0000468 ! multicellular organism
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21234" xsd:anyURI

[Term]
id: GO:0007276
name: gamete generation
namespace: biological_process
alt_id: GO:0009552
def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
synonym: "gametogenesis" RELATED []
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0019953 ! sexual reproduction
property_value: RO:0002161 NCBITaxon_Union:0000023

[Term]
id: GO:0007281
name: germ cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
synonym: "gametogenesis" NARROW []
synonym: "germ-cell development" EXACT []
synonym: "primordial germ cell development" NARROW []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000586 ! germ cell
relationship: part_of GO:0007276 ! gamete generation
relationship: results_in_development_of CL:0000586 ! germ cell

[Term]
id: GO:0007283
name: spermatogenesis
namespace: biological_process
def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
synonym: "generation of spermatozoa" EXACT systematic_synonym []
xref: Wikipedia:Spermatogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048232 ! male gamete generation

[Term]
id: GO:0007284
name: spermatogonial cell division
namespace: biological_process
def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238]
comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'.
synonym: "spermatogonium division" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000020 ! spermatogonium
relationship: has_primary_input CL:0000020 ! spermatogonium
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007285
name: primary spermatocyte growth
namespace: biological_process
def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of CL:0000656 ! primary spermatocyte
relationship: part_of GO:0007283 ! spermatogenesis
relationship: results_in_growth_of CL:0000656 ! primary spermatocyte

[Term]
id: GO:0007286
name: spermatid development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]
synonym: "spermatid cell development" EXACT []
synonym: "spermiogenesis" EXACT []
xref: Wikipedia:Spermiogenesis
is_a: GO:0007281 ! germ cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000018 ! spermatid
relationship: part_of GO:0048515 ! spermatid differentiation
relationship: results_in_development_of CL:0000018 ! spermatid

[Term]
id: GO:0007288
name: sperm axoneme assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0035082 ! axoneme assembly
intersection_of: GO:0035082 ! axoneme assembly
intersection_of: occurs_in CL:0000019 ! sperm
relationship: occurs_in CL:0000019 ! sperm
relationship: part_of GO:0120316 ! sperm flagellum assembly

[Term]
id: GO:0007289
name: spermatid nucleus differentiation
namespace: biological_process
def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.
synonym: "spermatid nuclear differentiation" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007292
name: female gamete generation
namespace: biological_process
def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007293
name: germarium-derived egg chamber formation
namespace: biological_process
def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: in_taxon NCBITaxon:6656 {all_only="true"} ! Arthropoda
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007308
name: oocyte construction
namespace: biological_process
alt_id: GO:0048110
def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732]
synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_formation_of_anatomical_entity CL:0000023 ! oocyte
relationship: part_of GO:0048599 ! oocyte development
relationship: results_in_formation_of_anatomical_entity CL:0000023 ! oocyte

[Term]
id: GO:0007309
name: oocyte axis specification
namespace: biological_process
alt_id: GO:0048111
def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte axis determination" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009798 ! axis specification
intersection_of: GO:0009798 ! axis specification
intersection_of: occurs_in CL:0000023 ! oocyte
relationship: occurs_in CL:0000023 ! oocyte
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0007314
name: oocyte anterior/posterior axis specification
namespace: biological_process
alt_id: GO:0048112
def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
intersection_of: GO:0009948 ! anterior/posterior axis specification
intersection_of: occurs_in CL:0000023 ! oocyte
relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo

[Term]
id: GO:0007320
name: insemination
namespace: biological_process
def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089]
xref: Wikipedia:Insemination
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0007338
name: single fertilization
namespace: biological_process
def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
synonym: "zygote biosynthesis" RELATED []
synonym: "zygote formation" RELATED []
is_a: GO:0009566 ! fertilization
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
property_value: RO:0002161 NCBITaxon:58024

[Term]
id: GO:0007343
name: egg activation
namespace: biological_process
def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
xref: Wikipedia:Egg_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000025 ! egg cell
relationship: has_primary_input CL:0000025 ! egg cell
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007346
name: regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000278 ! mitotic cell cycle
relationship: regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007350
name: blastoderm segmentation
namespace: biological_process
def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
is_a: GO:0035282 ! segmentation

[Term]
id: GO:0007351
name: tripartite regional subdivision
namespace: biological_process
def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007354
name: zygotic determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo
intersection_of: GO:0008595 ! anterior/posterior axis specification, embryo
intersection_of: occurs_in CL:0000365 ! animal zygote
relationship: occurs_in CL:0000365 ! animal zygote

[Term]
id: GO:0007369
name: gastrulation
namespace: biological_process
def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]
subset: goslim_drosophila
xref: Wikipedia:Gastrulation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: has_part GO:0001705 ! ectoderm formation
relationship: has_part GO:0001706 ! endoderm formation
relationship: has_part GO:0001707 ! mesoderm formation

[Term]
id: GO:0007389
name: pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
subset: goslim_drosophila
synonym: "pattern biosynthesis" RELATED []
synonym: "pattern formation" RELATED []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0007398
name: ectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000924 ! ectoderm
relationship: results_in_development_of UBERON:0000924 ! ectoderm

[Term]
id: GO:0007399
name: nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
subset: goslim_drosophila
synonym: "pan-neural process" RELATED []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001016 ! nervous system
relationship: results_in_development_of UBERON:0001016 ! nervous system

[Term]
id: GO:0007405
name: neuroblast proliferation
namespace: biological_process
alt_id: GO:0043349
alt_id: GO:0043350
def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: acts_on_population_of CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007406
name: negative regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
synonym: "down regulation of neuroblast proliferation" EXACT []
synonym: "down-regulation of neuroblast proliferation" EXACT []
synonym: "downregulation of neuroblast proliferation" EXACT []
synonym: "inhibition of neuroblast proliferation" NARROW []
synonym: "suppression of neuroblast proliferation" EXACT []
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:1902692 ! regulation of neuroblast proliferation
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007405 ! neuroblast proliferation
relationship: negatively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0007407
name: neuroblast activation
namespace: biological_process
alt_id: GO:0043351
alt_id: GO:0043352
def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_primary_input CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]
subset: goslim_synapse
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0050808 ! synapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_assembly_of GO:0045202 ! synapse
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_assembly_of GO:0045202 ! synapse

[Term]
id: GO:0007417
name: central nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]
synonym: "CNS development" EXACT []
xref: Wikipedia:Neural_development
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001017 ! central nervous system
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_development_of UBERON:0001017 ! central nervous system

[Term]
id: GO:0007420
name: brain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000955 ! brain
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0060322 ! head development
relationship: results_in_development_of UBERON:0000955 ! brain

[Term]
id: GO:0007422
name: peripheral nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000010 ! peripheral nervous system
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_development_of UBERON:0000010 ! peripheral nervous system

[Term]
id: GO:0007423
name: sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
subset: goslim_drosophila
synonym: "sense organ development" EXACT [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000020 ! sense organ
relationship: results_in_development_of UBERON:0000020 ! sense organ

[Term]
id: GO:0007439
name: ectodermal digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators]
synonym: "ectodermal gut development" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004906 ! ectodermal part of digestive tract
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_formation_of_anatomical_entity UBERON:0004906 ! ectodermal part of digestive tract

[Term]
id: GO:0007440
name: foregut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001041 ! foregut
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001041 ! foregut

[Term]
id: GO:0007442
name: hindgut morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001046 ! hindgut
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0061525 ! hindgut development
relationship: results_in_morphogenesis_of UBERON:0001046 ! hindgut

[Term]
id: GO:0007492
name: endoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000925 ! endoderm
relationship: results_in_development_of UBERON:0000925 ! endoderm

[Term]
id: GO:0007494
name: midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045]
is_a: GO:0048565 ! digestive tract development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001045 ! midgut
relationship: results_in_development_of UBERON:0001045 ! midgut

[Term]
id: GO:0007498
name: mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000926 ! mesoderm
relationship: results_in_development_of UBERON:0000926 ! mesoderm

[Term]
id: GO:0007506
name: gonadal mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003855 ! gonad mesenchyme
relationship: part_of GO:0008406 ! gonad development
relationship: results_in_development_of UBERON:0003855 ! gonad mesenchyme

[Term]
id: GO:0007507
name: heart development
namespace: biological_process
alt_id: GO:0007511
def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]
synonym: "cardiac development" RELATED []
synonym: "dorsal vessel development" NARROW []
xref: Wikipedia:Heart_development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0007100 ! primary circulatory organ
relationship: part_of GO:0072359 ! circulatory system development
relationship: results_in_development_of UBERON:0007100 ! primary circulatory organ

[Term]
id: GO:0007517
name: muscle organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]
is_a: GO:0048513 ! animal organ development
is_a: GO:0061061 ! muscle structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001630 ! muscle organ
relationship: results_in_development_of UBERON:0001630 ! muscle organ

[Term]
id: GO:0007519
name: skeletal muscle tissue development
namespace: biological_process
alt_id: GO:0048637
def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle]
synonym: "myogenesis" RELATED []
is_a: GO:0014706 ! striated muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of GO:0060538 ! skeletal muscle organ development
relationship: results_in_development_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: GO:0007525
name: somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle]
is_a: GO:0061061 ! muscle structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0014895 ! somatic muscle
relationship: results_in_development_of UBERON:0014895 ! somatic muscle

[Term]
id: GO:0007528
name: neuromuscular junction development
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]
synonym: "neuromuscular junction organization" EXACT []
synonym: "neuromuscular junction stability" RELATED [GOC:pr]
synonym: "NMJ stability" RELATED [GOC:pr]
is_a: GO:0050808 ! synapse organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0031594 ! neuromuscular junction
relationship: results_in_organization_of GO:0031594 ! neuromuscular junction

[Term]
id: GO:0007548
name: sex differentiation
namespace: biological_process
def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai]
xref: Wikipedia:Sexual_differentiation
is_a: GO:0003006 ! developmental process involved in reproduction

[Term]
id: GO:0007565
name: female pregnancy
namespace: biological_process
def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825]
subset: goslim_chembl
synonym: "carrying of young" RELATED []
synonym: "gestation" EXACT []
xref: Wikipedia:Gestation
is_a: GO:0044703 ! multi-organism reproductive process
is_a: GO:0044706 ! multi-multicellular organism process
relationship: in_taxon NCBITaxon:40674 {all_only="true"} ! Mammalia
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia

[Term]
id: GO:0007566
name: embryo implantation
namespace: biological_process
def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com]
synonym: "blastocyst implantation" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0007585
name: respiratory gaseous exchange by respiratory system
namespace: biological_process
def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732]
subset: goslim_chembl
synonym: "breathing" BROAD []
synonym: "respiration" BROAD []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
xref: Wikipedia:Digestion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: gocheck_do_not_annotate
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0003008 ! system process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI

[Term]
id: GO:0007589
name: body fluid secretion
namespace: biological_process
def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007600
name: sensory perception
namespace: biological_process
def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
subset: goslim_drosophila
xref: Wikipedia:Perception
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0007601
name: visual perception
namespace: biological_process
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
synonym: "sense of sight" EXACT []
synonym: "sensory visual perception" EXACT []
synonym: "vision" EXACT []
xref: Wikipedia:Visual_perception
is_a: GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0007605
name: sensory perception of sound
namespace: biological_process
def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
synonym: "hearing" EXACT []
synonym: "perception of sound" EXACT []
xref: Wikipedia:Hearing_(sense)
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemosensory perception" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
alt_id: GO:0023032
alt_id: GO:0044708
alt_id: GO:0044709
def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).
subset: gocheck_do_not_manually_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
synonym: "single-organism behavior" RELATED []
xref: Wikipedia:Behavior
is_a: GO:0032501 ! multicellular organismal process
disjoint_from: GO:0032502 ! developmental process
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: process_has_causal_agent UBERON:0001016 ! nervous system
created_by: jl
creation_date: 2012-09-20T14:06:08Z

[Term]
id: GO:0007617
name: mating behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
synonym: "mating behaviour" EXACT []
xref: Wikipedia:Mating_behaviour
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0007620
name: copulation
namespace: biological_process
def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544]
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0007626
name: locomotory behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
subset: goslim_drosophila
synonym: "behavior via locomotion" EXACT []
synonym: "locomotion in response to stimulus" EXACT []
synonym: "locomotory behavioral response to stimulus" EXACT []
synonym: "locomotory behaviour" EXACT []
synonym: "locomotory behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
alt_id: GO:0070261
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008016
name: regulation of heart contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cardiac contraction" EXACT []
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060047 ! heart contraction
relationship: regulates GO:0060047 ! heart contraction

[Term]
id: GO:0008028
name: monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008505
def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol"
xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:25384 ! monocarboxylic acid
relationship: has_primary_input CHEBI:25384 ! monocarboxylic acid
relationship: part_of GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0008078
name: mesodermal cell migration
namespace: biological_process
def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047]
synonym: "mesoderm cell migration" EXACT []
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000222 ! mesodermal cell
relationship: results_in_movement_of CL:0000222 ! mesodermal cell

[Term]
id: GO:0008088
name: axo-dendritic transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axon cargo transport" NARROW []
synonym: "axonal transport" NARROW []
synonym: "axoplasmic transport" NARROW []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0010970 ! transport along microtubule
intersection_of: GO:0046907 ! intracellular transport
intersection_of: occurs_in GO:0043005 ! neuron projection
intersection_of: results_in_transport_along GO:0005874 ! microtubule
relationship: occurs_in GO:0043005 ! neuron projection

[Term]
id: GO:0008104
name: protein localization
namespace: biological_process
alt_id: GO:0008105
alt_id: GO:0016249
alt_id: GO:0034613
def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]
subset: goslim_drosophila
synonym: "asymmetric protein localisation" RELATED [GOC:mah]
synonym: "asymmetric protein localization" RELATED []
synonym: "cellular protein localisation" EXACT [GOC:mah]
synonym: "cellular protein localization" EXACT []
synonym: "channel localizer activity" NARROW [GOC:mah]
synonym: "establishment and maintenance of asymmetric protein localization" RELATED []
synonym: "establishment and maintenance of protein localization" RELATED []
synonym: "protein localisation" EXACT [GOC:mah]
is_a: GO:0070727 ! cellular macromolecule localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input PR:000000001 ! protein
relationship: has_primary_input PR:000000001 ! protein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0008150
name: biological process
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
alt_id: GO:0044699
def: "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]
def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
subset: goslim_candida
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
synonym: "biological process" EXACT []
synonym: "physiological process" EXACT []
synonym: "single organism process" RELATED []
synonym: "single-organism process" RELATED []
xref: Wikipedia:Biological_process
is_a: BFO:0000015 ! process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24968" xsd:anyURI
created_by: jl
creation_date: 2012-09-19T15:05:24Z

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
alt_id: GO:0044236
alt_id: GO:0044710
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: gocheck_do_not_manually_annotate
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
synonym: "metabolic process resulting in cell growth" NARROW []
synonym: "metabolism" EXACT []
synonym: "metabolism resulting in cell growth" NARROW []
synonym: "multicellular organism metabolic process" NARROW []
synonym: "single-organism metabolic process" RELATED []
xref: Wikipedia:Metabolism
is_a: GO:0008150 ! biological process
disjoint_from: GO:0051179 ! localization
created_by: jl
creation_date: 2012-10-17T15:46:40Z

[Term]
id: GO:0008202
name: steroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]
synonym: "steroid metabolism" EXACT []
xref: Wikipedia:Steroid_metabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35341 ! steroid
relationship: has_primary_input_or_output CHEBI:35341 ! steroid

[Term]
id: GO:0008206
name: bile acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators]
synonym: "bile acid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:36235 ! bile acid anion
relationship: has_primary_input_or_output CHEBI:36235 ! bile acid anion

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]
comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms.
subset: gocheck_do_not_annotate
synonym: "accidental cell death" RELATED []
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI

[Term]
id: GO:0008272
name: sulfate transport
namespace: biological_process
alt_id: GO:0006870
def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0072348 ! sulfur compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:16189 ! sulfate
relationship: has_primary_input CHEBI:16189 ! sulfate

[Term]
id: GO:0008283
name: cell population proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "cell proliferation" RELATED []
is_a: GO:0009987 ! cellular process
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0008284
name: positive regulation of cell population proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "activation of cell proliferation" NARROW []
synonym: "positive regulation of cell proliferation" RELATED []
synonym: "stimulation of cell proliferation" NARROW []
synonym: "up regulation of cell proliferation" EXACT []
synonym: "up-regulation of cell proliferation" EXACT []
synonym: "upregulation of cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008283 ! cell population proliferation
relationship: positively_regulates GO:0008283 ! cell population proliferation
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0008285
name: negative regulation of cell population proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "down regulation of cell proliferation" EXACT []
synonym: "down-regulation of cell proliferation" EXACT []
synonym: "downregulation of cell proliferation" EXACT []
synonym: "inhibition of cell proliferation" NARROW []
synonym: "negative regulation of cell proliferation" RELATED []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008283 ! cell population proliferation
relationship: negatively_regulates GO:0008283 ! cell population proliferation
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0008291
name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:1900619 ! acetate ester metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:15355 ! acetylcholine
relationship: has_primary_input_or_output CHEBI:15355 ! acetylcholine

[Term]
id: GO:0008292
name: acetylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine anabolism" EXACT []
synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:1900620 ! acetate ester biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:15355 ! acetylcholine
relationship: has_primary_output CHEBI:15355 ! acetylcholine

[Term]
id: GO:0008320
name: protein transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015266
alt_id: GO:0015463
def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl]
synonym: "protein channel activity" RELATED []
xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space"
xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix"
xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex"
xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane"
xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria"
xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)"
xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol"
xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen"
xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol"
xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol"
xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane"
xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol"
xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation"
xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation"
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0140318 ! protein transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: part_of GO:0071806 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! protein transmembrane transport

[Term]
id: GO:0008324
name: monoatomic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "cation transmembrane transporter activity" BROAD []
synonym: "transmembrane cation transporter activity" EXACT []
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation
relationship: has_primary_input CHEBI:23906 ! monoatomic cation
relationship: part_of GO:0098655 ! monoatomic cation transmembrane transport
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI

[Term]
id: GO:0008347
name: glial cell migration
namespace: biological_process
alt_id: GO:0043359
def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
synonym: "glia cell migration" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000125 ! glial cell
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0042063 ! gliogenesis
relationship: results_in_movement_of CL:0000125 ! glial cell

[Term]
id: GO:0008354
name: germ cell migration
namespace: biological_process
def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
synonym: "germ-cell migration" EXACT []
synonym: "primordial germ cell migration" RELATED []
is_a: GO:0016477 ! cell migration
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000586 ! germ cell
relationship: part_of GO:0007276 ! gamete generation
relationship: results_in_movement_of CL:0000586 ! germ cell

[Term]
id: GO:0008356
name: asymmetric cell division
namespace: biological_process
def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
synonym: "asymmetric cytokinesis" RELATED []
synonym: "asymmetrical cell division" EXACT []
synonym: "asymmetrical cytokinesis" RELATED []
xref: Wikipedia:Asymmetric_cell_division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0008358
name: maternal determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0008406
name: gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732]
synonym: "gonadogenesis" EXACT [GOC:cjm]
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000991 ! gonad
relationship: part_of GO:0045137 ! development of primary sexual characteristics
relationship: results_in_development_of UBERON:0000991 ! gonad

[Term]
id: GO:0008504
name: monoamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015201
def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah]
xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles"
xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles"
xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse"
xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines"
xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol"
is_a: GO:0022804 ! active transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:63534 ! monoamine
relationship: has_primary_input CHEBI:63534 ! monoamine
relationship: part_of GO:0015844 ! monoamine transport

[Term]
id: GO:0008514
name: organic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]
xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5"
xref: Reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids"
xref: Reactome:R-HSA-9794830 "SLC22A8 transports Cipro into renal cell"
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:25696 ! organic anion
relationship: has_primary_input CHEBI:25696 ! organic anion
relationship: part_of GO:0015711 ! organic anion transport

[Term]
id: GO:0008544
name: epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]
synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0009888 ! tissue development
property_value: RO:0002161 NCBITaxon:33090

[Term]
id: GO:0008584
name: male gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid]
synonym: "testicular development" EXACT [GOC:sl]
synonym: "testis development" EXACT [GOC:sl]
is_a: GO:0008406 ! gonad development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000473 ! testis
relationship: part_of GO:0046546 ! development of primary male sexual characteristics
relationship: results_in_development_of UBERON:0000473 ! testis

[Term]
id: GO:0008585
name: female gonad development
namespace: biological_process
alt_id: GO:0061039
def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]
synonym: "ovarian development" RELATED [GOC:sl]
synonym: "ovary development" RELATED [GOC:sl]
is_a: GO:0008406 ! gonad development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000992 ! ovary
relationship: part_of GO:0046545 ! development of primary female sexual characteristics
relationship: results_in_development_of UBERON:0000992 ! ovary
property_value: RO:0002161 NCBITaxon:3398

[Term]
id: GO:0008594
name: photoreceptor cell morphogenesis
namespace: biological_process
def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah]
synonym: "photoreceptor development" RELATED []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of CL:0000210 ! photoreceptor cell
relationship: part_of GO:0042461 ! photoreceptor cell development
relationship: results_in_morphogenesis_of CL:0000210 ! photoreceptor cell

[Term]
id: GO:0008595
name: anterior/posterior axis specification, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0007351 ! tripartite regional subdivision

[Term]
id: GO:0008610
name: lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid anabolism" EXACT []
synonym: "lipid biosynthesis" EXACT []
synonym: "lipid formation" EXACT []
synonym: "lipid synthesis" EXACT []
synonym: "lipogenesis" EXACT [GOC:sl]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:18059 ! lipid
relationship: has_primary_output CHEBI:18059 ! lipid

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
alt_id: GO:0006861
alt_id: GO:0008644
def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "sugar transport" NARROW []
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:16646 ! carbohydrate
relationship: has_primary_input CHEBI:16646 ! carbohydrate

[Term]
id: GO:0008645
name: hexose transmembrane transport
namespace: biological_process
alt_id: GO:0008646
alt_id: GO:0008647
alt_id: GO:0035428
def: "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "hexose membrane transport" RELATED []
synonym: "hexose transport" RELATED []
synonym: "high-affinity hexose transport" NARROW []
synonym: "low-affinity hexose transport" NARROW []
is_a: GO:0015749 ! monosaccharide transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18133 ! hexose
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:18133 ! hexose
created_by: bf
creation_date: 2010-04-08T10:27:23Z

[Term]
id: GO:0008652
name: amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]
synonym: "amino acid anabolism" EXACT []
synonym: "amino acid biosynthesis" EXACT []
synonym: "amino acid formation" EXACT []
synonym: "amino acid synthesis" EXACT []
synonym: "cellular amino acid biosynthetic process" EXACT []
xref: Wikipedia:Amino_acid_synthesis
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:37022 ! amino-acid anion
relationship: has_primary_output CHEBI:37022 ! amino-acid anion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI

[Term]
id: GO:0009056
name: catabolic process
namespace: biological_process
alt_id: GO:0044243
alt_id: GO:0044712
def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_plant
synonym: "breakdown" EXACT []
synonym: "catabolism" EXACT []
synonym: "degradation" EXACT []
synonym: "multicellular organismal catabolic process" NARROW []
synonym: "single-organism catabolic process" RELATED []
xref: Wikipedia:Catabolism
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2012-10-17T15:52:35Z

[Term]
id: GO:0009057
name: macromolecule catabolic process
namespace: biological_process
alt_id: GO:0043285
alt_id: GO:0044266
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: goslim_pir
synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule catabolic process" RELATED []
synonym: "cellular macromolecule catabolism" RELATED []
synonym: "cellular macromolecule degradation" RELATED []
synonym: "macromolecule breakdown" EXACT []
synonym: "macromolecule catabolism" EXACT []
synonym: "macromolecule degradation" EXACT []
synonym: "multicellular organismal macromolecule catabolic process" NARROW []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33694 ! biomacromolecule
relationship: has_primary_input CHEBI:33694 ! biomacromolecule

[Term]
id: GO:0009058
name: biosynthetic process
namespace: biological_process
alt_id: GO:0044274
alt_id: GO:0044711
def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
subset: goslim_chembl
subset: goslim_metagenomics
subset: goslim_plant
synonym: "anabolism" EXACT []
synonym: "biosynthesis" EXACT []
synonym: "formation" BROAD []
synonym: "multicellular organismal biosynthetic process" NARROW []
synonym: "single-organism biosynthetic process" RELATED []
synonym: "synthesis" EXACT []
xref: Wikipedia:Anabolism
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2012-10-17T15:52:18Z

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: goslim_pir
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33694 ! biomacromolecule
relationship: has_primary_output CHEBI:33694 ! biomacromolecule
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15249" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25418" xsd:anyURI

[Term]
id: GO:0009063
name: amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
synonym: "amino acid breakdown" EXACT []
synonym: "amino acid catabolism" EXACT []
synonym: "amino acid degradation" EXACT []
synonym: "cellular amino acid catabolic process" EXACT []
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:37022 ! amino-acid anion
relationship: has_primary_input CHEBI:37022 ! amino-acid anion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17904" xsd:anyURI

[Term]
id: GO:0009100
name: glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
subset: goslim_drosophila
synonym: "glycoprotein metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:1901135 ! carbohydrate derivative metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:17089 ! glycoprotein
relationship: has_primary_input_or_output CHEBI:17089 ! glycoprotein

[Term]
id: GO:0009101
name: glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]
synonym: "glycoprotein anabolism" EXACT []
synonym: "glycoprotein biosynthesis" EXACT []
synonym: "glycoprotein formation" EXACT []
synonym: "glycoprotein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:17089 ! glycoprotein
relationship: has_primary_output CHEBI:17089 ! glycoprotein

[Term]
id: GO:0009112
name: nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]
synonym: "nucleobase metabolism" EXACT []
is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:18282 ! nucleobase
relationship: has_primary_input_or_output CHEBI:18282 ! nucleobase

[Term]
id: GO:0009250
name: glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
synonym: "glucan anabolism" EXACT []
synonym: "glucan biosynthesis" EXACT []
synonym: "glucan formation" EXACT []
synonym: "glucan synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0044042 ! glucan metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:37163 ! glucan
relationship: has_primary_output CHEBI:37163 ! glucan

[Term]
id: GO:0009251
name: glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
synonym: "glucan breakdown" EXACT []
synonym: "glucan catabolism" EXACT []
synonym: "glucan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044042 ! glucan metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:37163 ! glucan
relationship: has_primary_input CHEBI:37163 ! glucan

[Term]
id: GO:0009306
name: protein secretion
namespace: biological_process
alt_id: GO:0045166
alt_id: GO:0045731
def: "The controlled release of proteins from a cell." [GOC:ai]
synonym: "glycoprotein secretion" NARROW []
synonym: "protein secretion during cell fate commitment" NARROW []
synonym: "protein secretion resulting in cell fate commitment" NARROW []
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell
is_a: GO:0035592 ! establishment of protein localization to extracellular region
is_a: GO:0071692 ! protein localization to extracellular region
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input PR:000000001 ! protein

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
alt_id: GO:0044106
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: goslim_chembl
subset: goslim_pir
synonym: "amine metabolism" EXACT []
synonym: "cellular amine metabolic process" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:32952 ! amine
relationship: has_primary_input_or_output CHEBI:32952 ! amine
created_by: jl
creation_date: 2009-07-15T11:55:44Z

[Term]
id: GO:0009309
name: amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine anabolism" EXACT []
synonym: "amine biosynthesis" EXACT []
synonym: "amine formation" EXACT []
synonym: "amine synthesis" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:32952 ! amine
relationship: has_primary_output CHEBI:32952 ! amine

[Term]
id: GO:0009310
name: amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
synonym: "amine breakdown" EXACT []
synonym: "amine catabolism" EXACT []
synonym: "amine degradation" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:32952 ! amine
relationship: has_primary_input CHEBI:32952 ! amine

[Term]
id: GO:0009314
name: response to radiation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
synonym: "response to electromagnetic radiation stimulus" EXACT []
synonym: "response to radiation stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009416
name: response to light stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
subset: goslim_plant
is_a: GO:0009314 ! response to radiation
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:30212 ! photon
relationship: has_primary_input CHEBI:30212 ! photon

[Term]
id: GO:0009566
name: fertilization
namespace: biological_process
def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]
synonym: "syngamy" EXACT []
xref: Wikipedia:Fertilisation
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0022414 ! reproductive process
intersection_of: results_in_formation_of_anatomical_entity CL:0010017 ! zygote
intersection_of: results_in_fusion_of GO:0043073 ! germ cell nucleus
relationship: part_of GO:0019953 ! sexual reproduction
relationship: results_in_formation_of_anatomical_entity CL:0010017 ! zygote
relationship: results_in_fusion_of GO:0043073 ! germ cell nucleus
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20176" xsd:anyURI

[Term]
id: GO:0009581
name: detection of external stimulus
namespace: biological_process
def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of external stimulus" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
namespace: biological_process
def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of abiotic stimulus" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
namespace: biological_process
def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators]
synonym: "detection of light" EXACT []
synonym: "perception of light" RELATED []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
namespace: biological_process
def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]
synonym: "perception of visible light" RELATED []
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009593
name: detection of chemical stimulus
namespace: biological_process
def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "chemoperception" EXACT []
synonym: "chemoreception" RELATED []
synonym: "detection of chemical substance" EXACT []
synonym: "perception of chemical stimulus" RELATED []
synonym: "perception of chemical substance" RELATED []
is_a: GO:0051606 ! detection of stimulus
relationship: part_of GO:0042221 ! response to chemical

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_drosophila
subset: goslim_plant
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009617
name: response to bacterium
namespace: biological_process
alt_id: GO:0009618
alt_id: GO:0009680
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
synonym: "response to bacteria" EXACT []
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input NCBITaxon:2 ! Bacteria
relationship: has_primary_input NCBITaxon:2 ! Bacteria

[Term]
id: GO:0009620
name: response to fungus
namespace: biological_process
alt_id: GO:0009621
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
synonym: "response to fungi" EXACT []
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input NCBITaxon:4751 ! Fungi
relationship: has_primary_input NCBITaxon:4751 ! Fungi

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_metagenomics
subset: goslim_plant
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16572" xsd:anyURI

[Term]
id: GO:0009636
name: response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]
subset: goslim_chembl
synonym: "detoxification response" NARROW []
synonym: "toxin resistance" RELATED []
synonym: "toxin susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
namespace: biological_process
def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
synonym: "anatomical structure organization" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "morphogenesis" EXACT []
xref: Wikipedia:Morphogenesis
is_a: GO:0032502 ! developmental process
disjoint_from: GO:0048856 ! anatomical structure development
disjoint_from: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0009712
name: catechol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684]
synonym: "catechol metabolic process" RELATED []
synonym: "catechol metabolism" RELATED []
is_a: GO:0018958 ! phenol-containing compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33566 ! catechols
relationship: has_primary_input_or_output CHEBI:33566 ! catechols

[Term]
id: GO:0009713
name: catechol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol anabolism" RELATED []
synonym: "catechol biosynthesis" RELATED []
synonym: "catechol biosynthetic process" RELATED []
synonym: "catechol formation" RELATED []
synonym: "catechol synthesis" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0046189 ! phenol-containing compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33566 ! catechols
relationship: has_primary_output CHEBI:33566 ! catechols

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_plant
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009725
name: response to hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]
synonym: "growth regulator" RELATED []
synonym: "response to hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009743
name: response to carbohydrate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl]
synonym: "response to carbohydrate stimulus" EXACT [GOC:dos]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:16646 ! carbohydrate
relationship: has_primary_input CHEBI:16646 ! carbohydrate

[Term]
id: GO:0009746
name: response to hexose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl]
synonym: "response to hexose stimulus" EXACT [GOC:dos]
is_a: GO:0034284 ! response to monosaccharide
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:18133 ! hexose
relationship: has_primary_input CHEBI:18133 ! hexose

[Term]
id: GO:0009749
name: response to glucose
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl]
synonym: "response to glucose stimulus" EXACT [GOC:dos]
is_a: GO:0009746 ! response to hexose
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:17234 ! glucose
relationship: has_primary_input CHEBI:17234 ! glucose

[Term]
id: GO:0009786
name: regulation of asymmetric cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008356 ! asymmetric cell division
relationship: regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0009790
name: embryo development
namespace: biological_process
alt_id: GO:0009795
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: gocheck_do_not_manually_annotate
subset: goslim_chembl
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Wikipedia:Embryogenesis
is_a: GO:0007275 ! multicellular organism development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000922 ! embryo
relationship: results_in_development_of UBERON:0000922 ! embryo

[Term]
id: GO:0009791
name: post-embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0009792
name: embryo development ending in birth or egg hatching
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0009790 ! embryo development
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0009798
name: axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "axis determination" RELATED []
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009820
name: alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
subset: goslim_chembl
synonym: "alkaloid metabolism" EXACT []
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:22315 ! alkaloid
relationship: has_primary_input_or_output CHEBI:22315 ! alkaloid

[Term]
id: GO:0009821
name: alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
synonym: "alkaloid anabolism" EXACT []
synonym: "alkaloid biosynthesis" EXACT []
synonym: "alkaloid formation" EXACT []
synonym: "alkaloid synthesis" EXACT []
xref: UM-BBD_enzymeID:e0711
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044550 ! secondary metabolite biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:22315 ! alkaloid
relationship: has_primary_output CHEBI:22315 ! alkaloid

[Term]
id: GO:0009822
name: alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
synonym: "alkaloid breakdown" EXACT []
synonym: "alkaloid catabolism" EXACT []
synonym: "alkaloid degradation" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:22315 ! alkaloid
relationship: has_primary_input CHEBI:22315 ! alkaloid

[Term]
id: GO:0009880
name: embryonic pattern specification
namespace: biological_process
def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
synonym: "embryonic pattern biosynthesis" BROAD []
synonym: "embryonic pattern formation" BROAD []
synonym: "ventral/lateral system" RELATED []
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0009887
name: animal organ morphogenesis
namespace: biological_process
def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]
synonym: "histogenesis and organogenesis" BROAD []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000062 ! organ
relationship: part_of GO:0048513 ! animal organ development
relationship: results_in_morphogenesis_of UBERON:0000062 ! organ

[Term]
id: GO:0009888
name: tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
synonym: "histogenesis" EXACT []
synonym: "histogenesis and organogenesis" BROAD []
xref: Wikipedia:Histogenesis
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000479 ! tissue
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: results_in_development_of UBERON:0000479 ! tissue
property_value: RO:0002161 NCBITaxon:147554
property_value: RO:0002161 NCBITaxon:33630
property_value: RO:0002161 NCBITaxon:33682
property_value: RO:0002161 NCBITaxon:38254
property_value: RO:0002161 NCBITaxon:4891

[Term]
id: GO:0009889
name: regulation of biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "regulation of anabolism" EXACT []
synonym: "regulation of biosynthesis" EXACT []
synonym: "regulation of formation" EXACT []
synonym: "regulation of synthesis" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009058 ! biosynthetic process
relationship: regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "down regulation of biosynthetic process" EXACT []
synonym: "down-regulation of biosynthetic process" EXACT []
synonym: "downregulation of biosynthetic process" EXACT []
synonym: "inhibition of biosynthetic process" NARROW []
synonym: "negative regulation of anabolism" EXACT []
synonym: "negative regulation of biosynthesis" EXACT []
synonym: "negative regulation of formation" EXACT []
synonym: "negative regulation of synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009058 ! biosynthetic process
relationship: negatively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009891
name: positive regulation of biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
synonym: "activation of biosynthetic process" NARROW []
synonym: "positive regulation of anabolism" EXACT []
synonym: "positive regulation of biosynthesis" EXACT []
synonym: "positive regulation of formation" EXACT []
synonym: "positive regulation of synthesis" EXACT []
synonym: "stimulation of biosynthetic process" NARROW []
synonym: "up regulation of biosynthetic process" EXACT []
synonym: "up-regulation of biosynthetic process" EXACT []
synonym: "upregulation of biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009058 ! biosynthetic process
relationship: positively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009892
name: negative regulation of metabolic process
namespace: biological_process
alt_id: GO:0044252
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "down regulation of metabolic process" EXACT []
synonym: "down-regulation of metabolic process" EXACT []
synonym: "downregulation of metabolic process" EXACT []
synonym: "inhibition of metabolic process" NARROW []
synonym: "inhibition of organismal metabolic process" NARROW []
synonym: "negative regulation of metabolism" EXACT []
synonym: "negative regulation of multicellular organismal metabolic process" NARROW []
synonym: "negative regulation of organismal metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008152 ! metabolic process
relationship: negatively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
namespace: biological_process
alt_id: GO:0044253
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
synonym: "activation of metabolic process" NARROW []
synonym: "positive regulation of metabolism" EXACT []
synonym: "positive regulation of multicellular organismal metabolic process" NARROW []
synonym: "positive regulation of organismal metabolism" NARROW []
synonym: "stimulation of metabolic process" NARROW []
synonym: "stimulation of organismal metabolic process" NARROW []
synonym: "up regulation of metabolic process" EXACT []
synonym: "up-regulation of metabolic process" EXACT []
synonym: "up-regulation of organismal metabolic process" NARROW []
synonym: "upregulation of metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008152 ! metabolic process
relationship: positively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009894
name: regulation of catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "regulation of breakdown" EXACT []
synonym: "regulation of catabolism" EXACT []
synonym: "regulation of degradation" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009056 ! catabolic process
relationship: regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009895
name: negative regulation of catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "down regulation of catabolic process" EXACT []
synonym: "down-regulation of catabolic process" EXACT []
synonym: "downregulation of catabolic process" EXACT []
synonym: "inhibition of catabolic process" NARROW []
synonym: "negative regulation of breakdown" EXACT []
synonym: "negative regulation of catabolism" EXACT []
synonym: "negative regulation of degradation" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009056 ! catabolic process
relationship: negatively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009896
name: positive regulation of catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
synonym: "activation of catabolic process" NARROW []
synonym: "positive regulation of breakdown" EXACT []
synonym: "positive regulation of catabolism" EXACT []
synonym: "positive regulation of degradation" EXACT []
synonym: "stimulation of catabolic process" NARROW []
synonym: "up regulation of catabolic process" EXACT []
synonym: "up-regulation of catabolic process" EXACT []
synonym: "upregulation of catabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009056 ! catabolic process
relationship: positively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009913
name: epidermal cell differentiation
namespace: biological_process
alt_id: GO:0043355
def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000362 ! epidermal cell
relationship: part_of GO:0008544 ! epidermis development
relationship: results_in_acquisition_of_features_of CL:0000362 ! epidermal cell

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0009948
name: anterior/posterior axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "anterior/posterior axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009952 ! anterior/posterior pattern specification

[Term]
id: GO:0009952
name: anterior/posterior pattern specification
namespace: biological_process
def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "anterior/posterior pattern formation" RELATED []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009966
name: regulation of signal transduction
namespace: biological_process
alt_id: GO:0035466
def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "regulation of signaling pathway" RELATED []
synonym: "regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007165 ! signal transduction
relationship: regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009967
name: positive regulation of signal transduction
namespace: biological_process
alt_id: GO:0035468
def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "activation of signal transduction" NARROW []
synonym: "positive regulation of signaling pathway" RELATED []
synonym: "positive regulation of signalling pathway" RELATED [GOC:mah]
synonym: "stimulation of signal transduction" NARROW []
synonym: "up regulation of signal transduction" EXACT []
synonym: "up-regulation of signal transduction" EXACT []
synonym: "upregulation of signal transduction" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007165 ! signal transduction
relationship: positively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009968
name: negative regulation of signal transduction
namespace: biological_process
alt_id: GO:0035467
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
synonym: "down regulation of signal transduction" EXACT []
synonym: "down-regulation of signal transduction" EXACT []
synonym: "downregulation of signal transduction" EXACT []
synonym: "inhibition of signal transduction" NARROW []
synonym: "negative regulation of signaling pathway" RELATED []
synonym: "negative regulation of signalling pathway" RELATED [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007165 ! signal transduction
relationship: negatively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0044763
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
subset: goslim_plant
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
synonym: "single-organism cellular process" RELATED []
is_a: GO:0008150 ! biological process
created_by: jl
creation_date: 2012-12-11T16:56:55Z

[Term]
id: GO:0009994
name: oocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
synonym: "oocyte cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000023 ! oocyte
relationship: part_of GO:0048477 ! oogenesis
relationship: results_in_acquisition_of_features_of CL:0000023 ! oocyte

[Term]
id: GO:0010001
name: glial cell differentiation
namespace: biological_process
alt_id: GO:0007404
alt_id: GO:0043360
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
synonym: "glia cell differentiation" EXACT []
synonym: "neuroglia differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000125 ! glial cell
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0042063 ! gliogenesis
relationship: results_in_acquisition_of_features_of CL:0000125 ! glial cell

[Term]
id: GO:0010002
name: cardioblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart]
synonym: "cardioblast cell differentiation" EXACT []
synonym: "cardiomyocyte generation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002664 ! cardioblast
relationship: results_in_acquisition_of_features_of CL:0002664 ! cardioblast

[Term]
id: GO:0010032
name: meiotic chromosome condensation
namespace: biological_process
def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030261 ! chromosome condensation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0030261 ! chromosome condensation
intersection_of: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0010033
name: response to organic substance
namespace: biological_process
alt_id: GO:1990367
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]
synonym: "process resulting in tolerance to organic substance" NARROW []
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0042221 ! response to chemical
intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity
relationship: has_primary_input CHEBI:50860 ! organic molecular entity

[Term]
id: GO:0010034
name: response to acetate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:30089 ! acetate
relationship: has_primary_input CHEBI:30089 ! acetate

[Term]
id: GO:0010035
name: response to inorganic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:24835 ! inorganic molecular entity
relationship: has_primary_input CHEBI:24835 ! inorganic molecular entity

[Term]
id: GO:0010038
name: response to metal ion
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
synonym: "heavy metal sensitivity/resistance" RELATED []
synonym: "response to heavy metal" NARROW []
synonym: "response to metal" EXACT []
is_a: GO:0010035 ! response to inorganic substance
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:25213 ! metal cation
relationship: has_primary_input CHEBI:25213 ! metal cation

[Term]
id: GO:0010070
name: zygote asymmetric cell division
namespace: biological_process
def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb]
synonym: "zygote asymmetric cytokinesis" RELATED []
is_a: GO:0008356 ! asymmetric cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: has_primary_input CL:0000365 ! animal zygote
relationship: has_primary_input CL:0000365 ! animal zygote

[Term]
id: GO:0010160
name: formation of animal organ boundary
namespace: biological_process
alt_id: GO:0048862
def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175]
synonym: "organ boundary specification" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048859 ! formation of anatomical boundary
intersection_of: occurs_in UBERON:0000062 ! organ
relationship: occurs_in UBERON:0000062 ! organ
relationship: part_of GO:0048645 ! animal organ formation

[Term]
id: GO:0010171
name: body morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000468 ! multicellular organism
relationship: results_in_morphogenesis_of UBERON:0000468 ! multicellular organism

[Term]
id: GO:0010200
name: response to chitin
namespace: biological_process
def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:17029 ! chitin
relationship: has_primary_input CHEBI:17029 ! chitin

[Term]
id: GO:0010243
name: response to organonitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419]
synonym: "response to organic nitrogen" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:35352 ! organonitrogen compound
relationship: has_primary_input CHEBI:35352 ! organonitrogen compound

[Term]
id: GO:0010256
name: endomembrane system organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]
subset: goslim_drosophila
synonym: "endomembrane organization" EXACT []
synonym: "endomembrane system organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0012505 ! endomembrane system
relationship: results_in_organization_of GO:0012505 ! endomembrane system

[Term]
id: GO:0010324
name: membrane invagination
namespace: biological_process
alt_id: GO:1902534
def: "The infolding of a membrane." [GOC:tb]
subset: goslim_yeast
synonym: "single-organism membrane invagination" RELATED []
is_a: GO:0061024 ! membrane organization
created_by: jl
creation_date: 2013-12-02T13:58:34Z

[Term]
id: GO:0010453
name: regulation of cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045165 ! cell fate commitment
relationship: regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010454
name: negative regulation of cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045165 ! cell fate commitment
relationship: negatively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010455
name: positive regulation of cell fate commitment
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045165 ! cell fate commitment
relationship: positively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010463
name: mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0008019 ! mesenchymal cell
relationship: acts_on_population_of CL:0008019 ! mesenchymal cell

[Term]
id: GO:0010464
name: regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010463 ! mesenchymal cell proliferation
relationship: regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0010467
name: gene expression
namespace: biological_process
def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
subset: goslim_flybase_ribbon
xref: Wikipedia:Gene_expression
is_a: GO:0009059 ! macromolecule biosynthetic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25419" xsd:anyURI

[Term]
id: GO:0010468
name: regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.
synonym: "gene regulation" RELATED [GOC:cjm]
synonym: "regulation of gene product expression" RELATED []
synonym: "regulation of protein expression" NARROW []
xref: Wikipedia:Regulation_of_gene_expression
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010467 ! gene expression
relationship: regulates GO:0010467 ! gene expression
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI

[Term]
id: GO:0010470
name: regulation of gastrulation
namespace: biological_process
def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007369 ! gastrulation
relationship: regulates GO:0007369 ! gastrulation

[Term]
id: GO:0010481
name: epidermal cell division
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124]
synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000362 ! epidermal cell
relationship: has_primary_input CL:0000362 ! epidermal cell

[Term]
id: GO:0010482
name: regulation of epidermal cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124]
synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010481 ! epidermal cell division
relationship: regulates GO:0010481 ! epidermal cell division

[Term]
id: GO:0010496
name: intercellular transport
namespace: biological_process
alt_id: GO:1902585
def: "The movement of substances between cells." [GOC:dhl]
synonym: "single organism intercellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intercellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: has_target_end_location CL:0000000 ! cell
intersection_of: has_target_start_location CL:0000000 ! cell
intersection_of: results_in_transport_across GO:0005615 ! extracellular space
relationship: has_target_end_location CL:0000000 ! cell
relationship: has_target_start_location CL:0000000 ! cell
relationship: results_in_transport_across GO:0005615 ! extracellular space
created_by: jl
creation_date: 2013-12-19T13:24:56Z

[Term]
id: GO:0010549
name: regulation of membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030397 ! membrane disassembly
relationship: regulates GO:0030397 ! membrane disassembly

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process
relationship: regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010557
name: positive regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process
relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process
relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010559
name: regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010560
name: positive regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010561
name: negative regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process
relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010562
name: positive regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006793 ! phosphorus metabolic process
relationship: positively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010563
name: negative regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006793 ! phosphorus metabolic process
relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010564
name: regulation of cell cycle process
namespace: biological_process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022402 ! cell cycle process
relationship: regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010565
name: regulation of cellular ketone metabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042180 ! cellular ketone metabolic process
relationship: regulates GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0010566
name: regulation of ketone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042181 ! ketone biosynthetic process
relationship: regulates GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0010567
name: regulation of ketone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042182 ! ketone catabolic process
relationship: regulates GO:0042182 ! ketone catabolic process

[Term]
id: GO:0010594
name: regulation of endothelial cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043542 ! endothelial cell migration
relationship: regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010595
name: positive regulation of endothelial cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0010634 ! positive regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043542 ! endothelial cell migration
relationship: positively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010596
name: negative regulation of endothelial cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0010633 ! negative regulation of epithelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043542 ! endothelial cell migration
relationship: negatively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process
relationship: positively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process
relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010608
name: post-transcriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
synonym: "posttranscriptional regulation of gene expression" EXACT []
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0010611
name: regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010612
name: regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb]
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014887 ! cardiac muscle adaptation
relationship: regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010613
name: positive regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010614
name: negative regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy
relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010615
name: positive regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014744 ! positive regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014887 ! cardiac muscle adaptation
relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010616
name: negative regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014745 ! negative regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014887 ! cardiac muscle adaptation
relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010623
name: programmed cell death involved in cell development
namespace: biological_process
def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure.
synonym: "developmental programmed cell death" BROAD []
synonym: "programmed cell death involved in development" BROAD []
is_a: GO:0012501 ! programmed cell death
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0012501 ! programmed cell death
intersection_of: part_of GO:0048468 ! cell development
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0010628
name: positive regulation of gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010467 ! gene expression
relationship: positively_regulates GO:0010467 ! gene expression
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI

[Term]
id: GO:0010629
name: negative regulation of gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]
comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
synonym: "gene silencing" RELATED []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010467 ! gene expression
relationship: negatively_regulates GO:0010467 ! gene expression
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI

[Term]
id: GO:0010631
name: epithelial cell migration
namespace: biological_process
def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000066 ! epithelial cell
relationship: part_of GO:0090132 ! epithelium migration
relationship: results_in_movement_of CL:0000066 ! epithelial cell

[Term]
id: GO:0010632
name: regulation of epithelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010631 ! epithelial cell migration
relationship: regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010633
name: negative regulation of epithelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010631 ! epithelial cell migration
relationship: negatively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010634
name: positive regulation of epithelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010631 ! epithelial cell migration
relationship: positively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010638
name: positive regulation of organelle organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "positive regulation of organelle organisation" EXACT [GOC:mah]
synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006996 ! organelle organization
relationship: positively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010639
name: negative regulation of organelle organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of organelle organisation" EXACT [GOC:mah]
synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006996 ! organelle organization
relationship: negatively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010646
name: regulation of cell communication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007154 ! cell communication
relationship: regulates GO:0007154 ! cell communication

[Term]
id: GO:0010647
name: positive regulation of cell communication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007154 ! cell communication
relationship: positively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010648
name: negative regulation of cell communication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007154 ! cell communication
relationship: negatively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010656
name: negative regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "negative regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010657 ! muscle cell apoptotic process
relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010657
name: muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "muscle cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000187 ! muscle cell
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in CL:0000187 ! muscle cell
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0010658
name: striated muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "striated muscle cell apoptosis" NARROW []
is_a: GO:0010657 ! muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000737 ! striated muscle cell
relationship: occurs_in CL:0000737 ! striated muscle cell

[Term]
id: GO:0010659
name: cardiac muscle cell apoptotic process
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010658 ! striated muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000746 ! cardiac muscle cell
relationship: occurs_in CL:0000746 ! cardiac muscle cell

[Term]
id: GO:0010660
name: regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of muscle cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010657 ! muscle cell apoptotic process
relationship: regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010661
name: positive regulation of muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010657 ! muscle cell apoptotic process
relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process

[Term]
id: GO:0010662
name: regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010663
name: positive regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010664
name: negative regulation of striated muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of striated muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process
relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process

[Term]
id: GO:0010665
name: regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010666
name: positive regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb]
synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010667
name: negative regulation of cardiac muscle cell apoptotic process
namespace: biological_process
def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb]
synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb]
synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW []
is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process
relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process

[Term]
id: GO:0010668
name: ectodermal cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000221 ! ectodermal cell
relationship: part_of GO:0007398 ! ectoderm development
relationship: results_in_acquisition_of_features_of CL:0000221 ! ectodermal cell

[Term]
id: GO:0010700
name: negative regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048243 ! norepinephrine secretion
relationship: negatively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010701
name: positive regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048243 ! norepinephrine secretion
relationship: positively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010710
name: regulation of collagen catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030574 ! collagen catabolic process
relationship: regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010711
name: negative regulation of collagen catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030574 ! collagen catabolic process
relationship: negatively_regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010712
name: regulation of collagen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032963 ! collagen metabolic process
relationship: regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010713
name: negative regulation of collagen metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032963 ! collagen metabolic process
relationship: negatively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010714
name: positive regulation of collagen metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032963 ! collagen metabolic process
relationship: positively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010715
name: regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022617 ! extracellular matrix disassembly
relationship: regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010716
name: negative regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022617 ! extracellular matrix disassembly
relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010717
name: regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010718
name: positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010719
name: negative regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition
relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010720
name: positive regulation of cell development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048468 ! cell development
relationship: positively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010721
name: negative regulation of cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048468 ! cell development
relationship: negatively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010761
name: fibroblast migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000057 ! fibroblast
relationship: results_in_movement_of CL:0000057 ! fibroblast

[Term]
id: GO:0010762
name: regulation of fibroblast migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010761 ! fibroblast migration
relationship: regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010763
name: positive regulation of fibroblast migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010761 ! fibroblast migration
relationship: positively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010764
name: negative regulation of fibroblast migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010761 ! fibroblast migration
relationship: negatively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010765
name: positive regulation of sodium ion transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006814 ! sodium ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010766
name: negative regulation of sodium ion transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006814 ! sodium ion transport
relationship: negatively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010770
name: positive regulation of cell morphogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000902 ! cell morphogenesis
relationship: positively_regulates GO:0000902 ! cell morphogenesis
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI

[Term]
id: GO:0010771
name: negative regulation of cell morphogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0022604 ! regulation of cell morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000902 ! cell morphogenesis
relationship: negatively_regulates GO:0000902 ! cell morphogenesis
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI

[Term]
id: GO:0010817
name: regulation of hormone levels
namespace: biological_process
def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]

[Term]
id: GO:0010827
name: regulation of glucose transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
synonym: "regulation of glucose transport" RELATED []
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904659 ! glucose transmembrane transport
relationship: regulates GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0010828
name: positive regulation of glucose transmembrane transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of glucose transport" RELATED []
is_a: GO:0010827 ! regulation of glucose transmembrane transport
is_a: GO:0034764 ! positive regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904659 ! glucose transmembrane transport
relationship: positively_regulates GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0010829
name: negative regulation of glucose transmembrane transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of glucose transport" RELATED []
is_a: GO:0010827 ! regulation of glucose transmembrane transport
is_a: GO:0034763 ! negative regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904659 ! glucose transmembrane transport
relationship: negatively_regulates GO:1904659 ! glucose transmembrane transport

[Term]
id: GO:0010830
name: regulation of myotube differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014902 ! myotube differentiation
relationship: regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010831
name: positive regulation of myotube differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014902 ! myotube differentiation
relationship: positively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010832
name: negative regulation of myotube differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014902 ! myotube differentiation
relationship: negatively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010842
name: retina layer formation
namespace: biological_process
def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]
synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb]
synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001781 ! layer of retina
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye
relationship: results_in_formation_of_anatomical_entity UBERON:0001781 ! layer of retina

[Term]
id: GO:0010876
name: lipid localization
namespace: biological_process
def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "lipid localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: has_primary_input CHEBI:18059 ! lipid
relationship: has_primary_input CHEBI:18059 ! lipid

[Term]
id: GO:0010893
name: positive regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006694 ! steroid biosynthetic process
relationship: positively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010894
name: negative regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006694 ! steroid biosynthetic process
relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010906
name: regulation of glucose metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006006 ! glucose metabolic process
relationship: regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010907
name: positive regulation of glucose metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006006 ! glucose metabolic process
relationship: positively_regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
namespace: biological_process
def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0032989 ! cellular anatomical entity morphogenesis

[Term]
id: GO:0010937
name: regulation of cytoplasmic microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb]
is_a: GO:0031114 ! regulation of microtubule depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010938 ! cytoplasmic microtubule depolymerization
relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization

[Term]
id: GO:0010938
name: cytoplasmic microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0031122 ! cytoplasmic microtubule organization
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0010948
name: negative regulation of cell cycle process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022402 ! cell cycle process
relationship: negatively_regulates GO:0022402 ! cell cycle process
created_by: tb
creation_date: 2009-04-27T09:53:22Z

[Term]
id: GO:0010959
name: regulation of metal ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0043269 ! regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030001 ! metal ion transport
relationship: regulates GO:0030001 ! metal ion transport
created_by: tb
creation_date: 2009-05-06T11:40:55Z

[Term]
id: GO:0010962
name: regulation of glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009250 ! glucan biosynthetic process
relationship: regulates GO:0009250 ! glucan biosynthetic process
created_by: tb
creation_date: 2009-05-11T12:17:53Z

[Term]
id: GO:0010966
name: regulation of phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006817 ! phosphate ion transport
relationship: regulates GO:0006817 ! phosphate ion transport
created_by: tb
creation_date: 2009-05-20T11:42:50Z

[Term]
id: GO:0010968
name: regulation of microtubule nucleation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0031113 ! regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007020 ! microtubule nucleation
relationship: regulates GO:0007020 ! microtubule nucleation
created_by: tb
creation_date: 2009-05-20T11:51:21Z

[Term]
id: GO:0010970
name: transport along microtubule
namespace: biological_process
def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph]
synonym: "microtubule-based transport" BROAD []
synonym: "movement along microtubule" EXACT []
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0099111 ! microtubule-based transport
intersection_of: GO:0006810 ! transport
intersection_of: results_in_transport_along GO:0005874 ! microtubule
relationship: results_in_transport_along GO:0005874 ! microtubule
created_by: tb
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0010975
name: regulation of neuron projection development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "regulation of neurite development" NARROW [GOC:mah]
synonym: "regulation of neurite formation" NARROW [GOC:mah]
synonym: "regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031175 ! neuron projection development
relationship: regulates GO:0031175 ! neuron projection development
created_by: tb
creation_date: 2009-06-01T10:44:45Z

[Term]
id: GO:0010976
name: positive regulation of neuron projection development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "positive regulation of neurite development" NARROW [GOC:mah]
synonym: "positive regulation of neurite formation" NARROW [GOC:mah]
synonym: "positive regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031346 ! positive regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031175 ! neuron projection development
relationship: positively_regulates GO:0031175 ! neuron projection development
created_by: tb
creation_date: 2009-06-01T10:46:44Z

[Term]
id: GO:0010977
name: negative regulation of neuron projection development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "growth cone collapse" RELATED [GOC:pr]
synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "negative regulation of neurite development" NARROW [GOC:mah]
synonym: "negative regulation of neurite formation" NARROW [GOC:mah]
synonym: "negative regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031345 ! negative regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031175 ! neuron projection development
relationship: negatively_regulates GO:0031175 ! neuron projection development
created_by: tb
creation_date: 2009-06-01T10:47:42Z

[Term]
id: GO:0012501
name: programmed cell death
namespace: biological_process
alt_id: GO:0016244
def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
subset: goslim_prokaryote
synonym: "caspase-independent apoptosis" RELATED []
synonym: "caspase-independent cell death" NARROW []
synonym: "non-apoptotic programmed cell death" NARROW []
synonym: "nonapoptotic programmed cell death" NARROW []
synonym: "PCD" RELATED []
synonym: "RCD" RELATED []
synonym: "regulated cell death" BROAD []
xref: Wikipedia:Programmed_cell_death
is_a: GO:0008219 ! cell death
intersection_of: GO:0008219 ! cell death
intersection_of: starts_with GO:0007165 ! signal transduction
relationship: starts_with GO:0007165 ! signal transduction
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24835" xsd:anyURI

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_flybase_ribbon
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0110165 ! cellular anatomical entity
relationship: has_part GO:0005773 ! vacuole
relationship: has_part GO:0005886 ! plasma membrane
relationship: part_of CL:0000000 ! cell

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]
xref: NIF_Subcellular:sao1153182838
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0031982 ! vesicle
relationship: part_of GO:0031982 ! vesicle

[Term]
id: GO:0014009
name: glial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
synonym: "glia proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000125 ! glial cell
relationship: acts_on_population_of CL:0000125 ! glial cell
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0014013
name: regulation of gliogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
is_a: GO:0050767 ! regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042063 ! gliogenesis
relationship: regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014014
name: negative regulation of gliogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "down regulation of gliogenesis" EXACT []
synonym: "down-regulation of gliogenesis" EXACT []
synonym: "downregulation of gliogenesis" EXACT []
synonym: "inhibition of gliogenesis" NARROW []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042063 ! gliogenesis
relationship: negatively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014015
name: positive regulation of gliogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "activation of gliogenesis" NARROW []
synonym: "stimulation of gliogenesis" NARROW []
synonym: "up regulation of gliogenesis" EXACT []
synonym: "up-regulation of gliogenesis" EXACT []
synonym: "upregulation of gliogenesis" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042063 ! gliogenesis
relationship: positively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014016
name: neuroblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of GO:0048699 ! generation of neurons
relationship: results_in_acquisition_of_features_of CL:0000031 ! neuroblast (sensu Vertebrata)

[Term]
id: GO:0014019
name: neuroblast development
namespace: biological_process
def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of GO:0014016 ! neuroblast differentiation
relationship: results_in_development_of CL:0000031 ! neuroblast (sensu Vertebrata)

[Term]
id: GO:0014020
name: primary neural tube formation
namespace: biological_process
alt_id: GO:0014024
def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585, PMID:15327780]
synonym: "neural rod cavitation" RELATED []
synonym: "primary neural tube morphogenesis" EXACT [GOC:dph]
synonym: "primary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014023
name: neural rod formation
namespace: biological_process
def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005068 ! neural rod
relationship: in_taxon NCBITaxon:32443 {all_only="true"} ! Teleostei
relationship: only_in_taxon NCBITaxon:32443 ! Teleostei
relationship: part_of GO:0014020 ! primary neural tube formation
relationship: results_in_formation_of_anatomical_entity UBERON:0005068 ! neural rod

[Term]
id: GO:0014025
name: neural keel formation
namespace: biological_process
def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0007135 ! neural keel
relationship: part_of GO:0014023 ! neural rod formation
relationship: results_in_formation_of_anatomical_entity UBERON:0007135 ! neural keel

[Term]
id: GO:0014028
name: notochord formation
namespace: biological_process
def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002328 ! notochord
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0048570 ! notochord morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002328 ! notochord

[Term]
id: GO:0014029
name: neural crest formation
namespace: biological_process
def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002342 ! neural crest
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: results_in_formation_of_anatomical_entity UBERON:0002342 ! neural crest

[Term]
id: GO:0014031
name: mesenchymal cell development
namespace: biological_process
def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0008019 ! mesenchymal cell
relationship: part_of GO:0048762 ! mesenchymal cell differentiation
relationship: results_in_development_of CL:0008019 ! mesenchymal cell

[Term]
id: GO:0014032
name: neural crest cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048864 ! stem cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0011012 ! neural crest cell
relationship: part_of GO:0014033 ! neural crest cell differentiation
relationship: results_in_development_of CL:0011012 ! neural crest cell

[Term]
id: GO:0014033
name: neural crest cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000333 ! migratory neural crest cell
relationship: results_in_acquisition_of_features_of CL:0000333 ! migratory neural crest cell

[Term]
id: GO:0014041
name: regulation of neuron maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042551 ! neuron maturation
relationship: regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014042
name: positive regulation of neuron maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "activation of neuron maturation" NARROW []
synonym: "stimulation of neuron maturation" NARROW []
synonym: "up regulation of neuron maturation" EXACT []
synonym: "up-regulation of neuron maturation" EXACT []
synonym: "upregulation of neuron maturation" EXACT []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903431 ! positive regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042551 ! neuron maturation
relationship: positively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014043
name: negative regulation of neuron maturation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "down regulation of neuron maturation" EXACT []
synonym: "down-regulation of neuron maturation" EXACT []
synonym: "downregulation of neuron maturation" EXACT []
synonym: "inhibition of neuron maturation" NARROW []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:1903430 ! negative regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042551 ! neuron maturation
relationship: negatively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014055
name: acetylcholine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0061526 ! acetylcholine secretion
intersection_of: GO:0061526 ! acetylcholine secretion
intersection_of: part_of GO:0007271 ! synaptic transmission, cholinergic
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0014056
name: regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014057
name: positive regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "activation of acetylcholine secretion" NARROW []
synonym: "stimulation of acetylcholine secretion" NARROW []
synonym: "up regulation of acetylcholine secretion" EXACT []
synonym: "up-regulation of acetylcholine secretion" EXACT []
synonym: "upregulation of acetylcholine secretion" EXACT []
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic
is_a: GO:0051954 ! positive regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014058
name: negative regulation of acetylcholine secretion, neurotransmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "down regulation of acetylcholine secretion" EXACT []
synonym: "down-regulation of acetylcholine secretion" EXACT []
synonym: "downregulation of acetylcholine secretion" EXACT []
synonym: "inhibition of acetylcholine secretion" NARROW []
is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission
is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission
relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission

[Term]
id: GO:0014061
name: regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef]
synonym: "regulation of noradrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048243 ! norepinephrine secretion
relationship: regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0014062
name: regulation of serotonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001820 ! serotonin secretion
relationship: regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014063
name: negative regulation of serotonin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "down regulation of serotonin secretion" EXACT []
synonym: "down-regulation of serotonin secretion" EXACT []
synonym: "downregulation of serotonin secretion" EXACT []
synonym: "inhibition of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001820 ! serotonin secretion
relationship: negatively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014064
name: positive regulation of serotonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "activation of serotonin secretion" NARROW []
synonym: "positive regulation of serotonin release" RELATED [GOC:tb]
synonym: "stimulation of serotonin secretion" NARROW []
synonym: "up regulation of serotonin secretion" EXACT []
synonym: "up-regulation of serotonin secretion" EXACT []
synonym: "upregulation of serotonin secretion" EXACT []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001820 ! serotonin secretion
relationship: positively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014070
name: response to organic cyclic compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef]
synonym: "response to organic cyclic substance" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:33832 ! organic cyclic compound
relationship: has_primary_input CHEBI:33832 ! organic cyclic compound

[Term]
id: GO:0014075
name: response to amine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef]
synonym: "response to amine stimulus" EXACT [GOC:dos]
is_a: GO:0010243 ! response to organonitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:32952 ! amine
relationship: has_primary_input CHEBI:32952 ! amine

[Term]
id: GO:0014706
name: striated muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]
is_a: GO:0060537 ! muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002036 ! striated muscle tissue
relationship: results_in_development_of UBERON:0002036 ! striated muscle tissue

[Term]
id: GO:0014733
name: regulation of skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043501 ! skeletal muscle adaptation
relationship: regulates GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014734
name: skeletal muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014897 ! striated muscle hypertrophy
is_a: GO:0043501 ! skeletal muscle adaptation
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: occurs_in UBERON:0001134 ! skeletal muscle tissue

[Term]
id: GO:0014741
name: negative regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014896 ! muscle hypertrophy
relationship: negatively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014742
name: positive regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014896 ! muscle hypertrophy
relationship: positively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014743
name: regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014896 ! muscle hypertrophy
relationship: regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014744
name: positive regulation of muscle adaptation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "positive regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043500 ! muscle adaptation
relationship: positively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014745
name: negative regulation of muscle adaptation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "negative regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043500 ! muscle adaptation
relationship: negatively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014805
name: smooth muscle adaptation
namespace: biological_process
def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "smooth muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: occurs_in UBERON:0001135 ! smooth muscle tissue
relationship: occurs_in UBERON:0001135 ! smooth muscle tissue

[Term]
id: GO:0014807
name: regulation of somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001756 ! somitogenesis
relationship: regulates GO:0001756 ! somitogenesis

[Term]
id: GO:0014812
name: muscle cell migration
namespace: biological_process
def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000187 ! muscle cell
relationship: results_in_movement_of CL:0000187 ! muscle cell

[Term]
id: GO:0014819
name: regulation of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0006942 ! regulation of striated muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003009 ! skeletal muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0014821
name: phasic smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014827
name: intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014831
name: gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014832
name: urinary bladder smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0014848 ! urinary tract smooth muscle contraction
property_value: RO:0002161 NCBITaxon:8782

[Term]
id: GO:0014848
name: urinary tract smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014849
name: ureter smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014852
name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014855
name: striated muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle]
is_a: GO:0033002 ! muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000737 ! striated muscle cell
relationship: acts_on_population_of CL:0000737 ! striated muscle cell

[Term]
id: GO:0014856
name: skeletal muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0014855 ! striated muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000188 ! cell of skeletal muscle
relationship: acts_on_population_of CL:0000188 ! cell of skeletal muscle

[Term]
id: GO:0014857
name: regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014858
name: positive regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014859
name: negative regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation
relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014860
name: neurotransmitter secretion involved in regulation of skeletal muscle contraction
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb]
synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007269 ! neurotransmitter secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: part_of GO:0014819 ! regulation of skeletal muscle contraction
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014861
name: regulation of skeletal muscle contraction via regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED []
is_a: GO:0014819 ! regulation of skeletal muscle contraction
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential
relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential

[Term]
id: GO:0014866
name: skeletal myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0030239 ! myofibril assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0098723 ! skeletal muscle myofibril
relationship: results_in_assembly_of GO:0098723 ! skeletal muscle myofibril

[Term]
id: GO:0014872
name: myoblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle]
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000056 ! myoblast
relationship: has_primary_input CL:0000056 ! myoblast

[Term]
id: GO:0014874
name: response to stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0050896 ! response to stimulus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation
relationship: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014878
name: response to electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
is_a: GO:0051602 ! response to electrical stimulus
intersection_of: GO:0051602 ! response to electrical stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014879
name: detection of electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
is_a: GO:0050981 ! detection of electrical stimulus
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0043502 ! regulation of muscle adaptation

[Term]
id: GO:0014887
name: cardiac muscle adaptation
namespace: biological_process
def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]
synonym: "cardiac muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: occurs_in UBERON:0001133 ! cardiac muscle tissue
relationship: occurs_in UBERON:0001133 ! cardiac muscle tissue

[Term]
id: GO:0014888
name: striated muscle adaptation
namespace: biological_process
def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "striated muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: occurs_in UBERON:0002036 ! striated muscle tissue
relationship: occurs_in UBERON:0002036 ! striated muscle tissue

[Term]
id: GO:0014895
name: smooth muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014896 ! muscle hypertrophy
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: occurs_in UBERON:0001135 ! smooth muscle tissue

[Term]
id: GO:0014896
name: muscle hypertrophy
namespace: biological_process
def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
xref: Wikipedia:Muscle_hypertrophy
is_a: GO:0003012 ! muscle system process
relationship: occurs_in UBERON:0002385 ! muscle tissue

[Term]
id: GO:0014897
name: striated muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014896 ! muscle hypertrophy
intersection_of: GO:0014896 ! muscle hypertrophy
intersection_of: has_primary_input UBERON:0002036 ! striated muscle tissue
relationship: has_primary_input UBERON:0002036 ! striated muscle tissue

[Term]
id: GO:0014902
name: myotube differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0051146 ! striated muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002372 ! myotube
relationship: results_in_acquisition_of_features_of CL:0002372 ! myotube

[Term]
id: GO:0014904
name: myotube cell development
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0055002 ! striated muscle cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0002372 ! myotube
relationship: part_of GO:0014902 ! myotube differentiation
relationship: results_in_development_of CL:0002372 ! myotube

[Term]
id: GO:0014909
name: smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000192 ! smooth muscle cell
relationship: results_in_movement_of CL:0000192 ! smooth muscle cell

[Term]
id: GO:0014910
name: regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014909 ! smooth muscle cell migration
relationship: regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014911
name: positive regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014909 ! smooth muscle cell migration
relationship: positively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014912
name: negative regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014909 ! smooth muscle cell migration
relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_yeast
synonym: "enzyme transport" NARROW []
is_a: GO:0008104 ! protein localization
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input PR:000000001 ! protein

[Term]
id: GO:0015075
name: monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]
synonym: "ion transmembrane transporter activity" BROAD []
synonym: "ion transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:24867 ! monoatomic ion
relationship: has_primary_input CHEBI:24867 ! monoatomic ion
relationship: part_of GO:0034220 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! monoatomic ion transmembrane transport
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI

[Term]
id: GO:0015081
name: sodium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022816
def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF, RHEA:34963]
synonym: "sodium transporter activity" EXACT []
xref: RHEA:34963
is_a: GO:0046873 ! metal ion transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:29101 ! sodium(1+)
relationship: has_participant CHEBI:29101 ! sodium(1+)
relationship: has_primary_input CHEBI:29101 ! sodium(1+)
relationship: part_of GO:0035725 ! sodium ion transmembrane transport
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24076" xsd:anyURI

[Term]
id: GO:0015101
name: organic cation transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]"
xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells"
xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney"
xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations"
xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells"
xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney"
xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations"
xref: Reactome:R-HSA-9794270 "SLCO1A2 transports Cipro(1+) into the cytosol"
xref: Reactome:R-HSA-9794523 "SLC22A1 transports Cipro into renal cell"
xref: Reactome:R-HSA-9795207 "SLC22A1 transports Cipro into hepatic cell"
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:25697 ! organic cation
relationship: has_primary_input CHEBI:25697 ! organic cation
relationship: part_of GO:0015695 ! organic cation transport

[Term]
id: GO:0015103
name: inorganic anion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:24834 ! inorganic anion
relationship: has_primary_input CHEBI:24834 ! inorganic anion
relationship: part_of GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015106
name: bicarbonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region"
xref: RHEA:28695
is_a: GO:0008514 ! organic anion transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate
relationship: has_participant CHEBI:17544 ! hydrogencarbonate
relationship: has_primary_input CHEBI:17544 ! hydrogencarbonate
relationship: part_of GO:0015701 ! bicarbonate transport

[Term]
id: GO:0015114
name: phosphate ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901677
def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw]
xref: RHEA:32823
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:35780 ! phosphate ion
relationship: has_participant CHEBI:43474 ! hydrogenphosphate
relationship: has_primary_input CHEBI:35780 ! phosphate ion
relationship: part_of GO:0035435 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! phosphate ion transmembrane transport
created_by: pr
creation_date: 2012-11-22T15:43:10Z

[Term]
id: GO:0015116
name: sulfate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]
synonym: "sulfate permease activity" RELATED []
synonym: "sulphate transporter activity" EXACT []
xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol"
xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol"
xref: RHEA:34983
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
is_a: GO:1901682 ! sulfur compound transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:16189 ! sulfate
relationship: has_participant CHEBI:16189 ! sulfate
relationship: has_primary_input CHEBI:16189 ! sulfate
relationship: part_of GO:1902358 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! sulfate transmembrane transport

[Term]
id: GO:0015123
name: acetate transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai]
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:30089 ! acetate
relationship: has_primary_input CHEBI:30089 ! acetate
relationship: part_of GO:0035433 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! acetate transmembrane transport

[Term]
id: GO:0015125
name: bile acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai]
xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol"
xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A"
xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)"
xref: Reactome:R-HSA-9733964 "SLC51A:SLC51B transports bile salts from cytosol to extracellular region"
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:3098 ! bile acid
relationship: has_primary_input CHEBI:3098 ! bile acid
relationship: part_of GO:0015721 ! bile acid and bile salt transport

[Term]
id: GO:0015127
name: bilirubin transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684]
xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region"
xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region"
xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:57977 ! bilirubin(2-)
relationship: has_primary_input CHEBI:57977 ! bilirubin(2-)
relationship: part_of GO:0015723 ! bilirubin transport

[Term]
id: GO:0015144
name: carbohydrate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:1901476
def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
synonym: "carbohydrate transporter activity" RELATED []
synonym: "sugar transporter" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:16646 ! carbohydrate
relationship: has_primary_input CHEBI:16646 ! carbohydrate
relationship: part_of GO:0034219 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! carbohydrate transmembrane transport

[Term]
id: GO:0015145
name: monosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0051119 ! sugar transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:35381 ! monosaccharide
relationship: has_primary_input CHEBI:35381 ! monosaccharide
relationship: part_of GO:0015749 ! monosaccharide transmembrane transport

[Term]
id: GO:0015149
name: hexose transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region"
xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:18133 ! hexose
relationship: has_primary_input CHEBI:18133 ! hexose
relationship: part_of GO:0008645 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! hexose transmembrane transport

[Term]
id: GO:0015159
name: polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:18154 ! polysaccharide
relationship: has_primary_input CHEBI:18154 ! polysaccharide
relationship: part_of GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015171
name: amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015359
def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "amino acid permease activity" EXACT []
synonym: "amino acid transporter activity" BROAD []
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "general amino acid permease activity" RELATED []
synonym: "hydroxy/aromatic amino acid permease activity" RELATED []
xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes"
xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons"
xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol"
xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine"
xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine"
xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol"
xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake"
xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids"
xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine"
xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids"
xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine"
xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine"
xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids"
xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol"
xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine"
xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine"
xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine"
xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine"
xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane"
xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane"
xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine"
xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids"
xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids"
xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate"
xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine"
xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol"
xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol"
xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol"
xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu"
xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane"
xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen"
xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol"
is_a: GO:0005342 ! organic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:33709 ! amino acid
relationship: has_primary_input CHEBI:33709 ! amino acid
relationship: part_of GO:0003333 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! amino acid transmembrane transport

[Term]
id: GO:0015205
name: nucleobase transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015392
def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:18282 ! nucleobase
relationship: has_primary_input CHEBI:18282 ! nucleobase
relationship: part_of GO:0015851 ! nucleobase transport

[Term]
id: GO:0015318
name: inorganic molecular entity transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729]
subset: gocheck_do_not_annotate
synonym: "inorganic solute uptake transmembrane transporter activity" EXACT []
synonym: "inorganic uptake permease activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:24835 ! inorganic molecular entity
relationship: has_primary_input CHEBI:24835 ! inorganic molecular entity
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14372" xsd:anyURI

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0015671
name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:15379 ! dioxygen
relationship: has_primary_input CHEBI:15379 ! dioxygen

[Term]
id: GO:0015695
name: organic cation transport
namespace: biological_process
def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:25697 ! organic cation
relationship: has_primary_input CHEBI:25697 ! organic cation

[Term]
id: GO:0015698
name: inorganic anion transport
namespace: biological_process
def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:24834 ! inorganic anion
relationship: has_primary_input CHEBI:24834 ! inorganic anion

[Term]
id: GO:0015701
name: bicarbonate transport
namespace: biological_process
def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015711 ! organic anion transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:17544 ! hydrogencarbonate
relationship: has_primary_input CHEBI:17544 ! hydrogencarbonate

[Term]
id: GO:0015711
name: organic anion transport
namespace: biological_process
def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:25696 ! organic anion
relationship: has_primary_input CHEBI:25696 ! organic anion

[Term]
id: GO:0015718
name: monocarboxylic acid transport
namespace: biological_process
def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0046942 ! carboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:35757 ! monocarboxylic acid anion
relationship: has_primary_input CHEBI:35757 ! monocarboxylic acid anion

[Term]
id: GO:0015721
name: bile acid and bile salt transport
namespace: biological_process
def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
synonym: "bile acid transport" NARROW []
synonym: "bile salt transport" NARROW []
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015849 ! organic acid transport
is_a: GO:0015850 ! organic hydroxy compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:3098 ! bile acid
relationship: has_primary_input CHEBI:3098 ! bile acid

[Term]
id: GO:0015723
name: bilirubin transport
namespace: biological_process
def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:57977 ! bilirubin(2-)
relationship: has_primary_input CHEBI:57977 ! bilirubin(2-)

[Term]
id: GO:0015749
name: monosaccharide transmembrane transport
namespace: biological_process
alt_id: GO:1905950
def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw]
synonym: "monosaccharide transport" RELATED []
is_a: GO:0034219 ! carbohydrate transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:35381 ! monosaccharide
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:35381 ! monosaccharide
created_by: vw
creation_date: 2017-02-19T10:41:27Z

[Term]
id: GO:0015774
name: polysaccharide transport
namespace: biological_process
def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18154 ! polysaccharide
relationship: has_primary_input CHEBI:18154 ! polysaccharide
relationship: part_of GO:0033037 ! polysaccharide localization

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
is_a: GO:0042886 ! amide transport
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:16670 ! peptide
relationship: has_primary_input CHEBI:16670 ! peptide

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:32952 ! amine
relationship: has_primary_input CHEBI:32952 ! amine

[Term]
id: GO:0015844
name: monoamine transport
namespace: biological_process
alt_id: GO:0015873
def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:63534 ! monoamine
relationship: has_primary_input CHEBI:63534 ! monoamine

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:64709 ! organic acid
relationship: has_primary_input CHEBI:64709 ! organic acid

[Term]
id: GO:0015850
name: organic hydroxy compound transport
namespace: biological_process
def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]
synonym: "organic alcohol transport" EXACT []
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound
relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound

[Term]
id: GO:0015851
name: nucleobase transport
namespace: biological_process
def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
synonym: "nucleobase transmembrane transport" EXACT [GOC:mah]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18282 ! nucleobase
relationship: has_primary_input CHEBI:18282 ! nucleobase

[Term]
id: GO:0015869
name: protein-DNA complex transport
namespace: biological_process
def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "DNA-protein complex transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0015931 ! nucleobase-containing compound transport
is_a: GO:0031503 ! protein-containing complex localization
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input GO:0032993 ! protein-DNA complex
relationship: has_primary_input GO:0032993 ! protein-DNA complex

[Term]
id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0015695 ! organic cation transport
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:1901374 ! acetate ester transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
relationship: has_primary_input CHEBI:15355 ! acetylcholine

[Term]
id: GO:0015874
name: norepinephrine transport
namespace: biological_process
def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732]
synonym: "levarterenol transport" EXACT []
synonym: "noradrenaline transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)

[Term]
id: GO:0015931
name: nucleobase-containing compound transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0071702 ! organic substance transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity

[Term]
id: GO:0015932
name: nucleobase-containing compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity
relationship: part_of GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0015980
name: energy derivation by oxidation of organic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
synonym: "chemoorganotrophy" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
alt_id: GO:0016021
alt_id: GO:0098589
alt_id: GO:0098805
def: "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "integral component of membrane" NARROW []
synonym: "integral to membrane" NARROW []
synonym: "membrane region" NARROW []
synonym: "region of membrane" NARROW []
synonym: "transmembrane" RELATED [GOC:mah]
synonym: "whole membrane" NARROW []
xref: Wikipedia:Biological_membrane
xref: Wikipedia:Transmembrane_protein
is_a: GO:0110165 ! cellular anatomical entity
disjoint_from: GO:0031012 ! extracellular matrix
creation_date: 2014-03-06T11:37:54Z

[Term]
id: GO:0016042
name: lipid catabolic process
namespace: biological_process
alt_id: GO:0006724
alt_id: GO:0044240
def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
synonym: "lipid breakdown" EXACT []
synonym: "lipid catabolism" EXACT []
synonym: "lipid degradation" EXACT []
synonym: "lipolysis" EXACT []
synonym: "multicellular organism lipid catabolic process" NARROW []
synonym: "multicellular organismal lipid catabolic process" NARROW []
xref: Wikipedia:Lipid_catabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:18059 ! lipid
relationship: has_primary_input CHEBI:18059 ! lipid

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
alt_id: GO:0044235
alt_id: GO:0071842
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: goslim_agr
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
synonym: "cellular component organisation at cellular level" EXACT [GOC:mah]
synonym: "cellular component organisation in other organism" EXACT [GOC:mah]
synonym: "cellular component organization at cellular level" EXACT []
synonym: "cellular component organization in other organism" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_organization_of GO:0005575 ! cellular_component
relationship: results_in_organization_of GO:0005575 ! cellular_component

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
alt_id: GO:0048591
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: gocheck_do_not_annotate
subset: goslim_drosophila
subset: goslim_pir
subset: goslim_plant
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0040007 ! growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of CL:0000000 ! cell
relationship: results_in_growth_of CL:0000000 ! cell

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT []
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0031982 ! vesicle
relationship: results_in_organization_of GO:0031982 ! vesicle

[Term]
id: GO:0016051
name: carbohydrate biosynthetic process
namespace: biological_process
alt_id: GO:0006093
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "anabolic carbohydrate metabolic process" EXACT []
synonym: "anabolic carbohydrate metabolism" EXACT []
synonym: "carbohydrate anabolism" EXACT []
synonym: "carbohydrate biosynthesis" EXACT []
synonym: "carbohydrate formation" EXACT []
synonym: "carbohydrate synthesis" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:16646 ! carbohydrate
relationship: has_primary_output CHEBI:16646 ! carbohydrate

[Term]
id: GO:0016052
name: carbohydrate catabolic process
namespace: biological_process
alt_id: GO:0006095
alt_id: GO:0044276
alt_id: GO:0044724
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]
synonym: "carbohydrate breakdown" EXACT []
synonym: "carbohydrate catabolism" EXACT []
synonym: "carbohydrate degradation" EXACT []
synonym: "catabolic carbohydrate metabolic process" EXACT []
synonym: "catabolic carbohydrate metabolism" EXACT []
synonym: "multicellular organismal carbohydrate catabolic process" NARROW []
synonym: "single-organism carbohydrate catabolic process" RELATED []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:16646 ! carbohydrate
relationship: has_primary_input CHEBI:16646 ! carbohydrate
created_by: jl
creation_date: 2012-10-23T16:34:39Z

[Term]
id: GO:0016053
name: organic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid anabolism" EXACT []
synonym: "organic acid biosynthesis" EXACT []
synonym: "organic acid formation" EXACT []
synonym: "organic acid synthesis" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:64709 ! organic acid
relationship: has_primary_output CHEBI:64709 ! organic acid

[Term]
id: GO:0016054
name: organic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
synonym: "organic acid breakdown" EXACT []
synonym: "organic acid catabolism" EXACT []
synonym: "organic acid degradation" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:64709 ! organic acid
relationship: has_primary_input CHEBI:64709 ! organic acid

[Term]
id: GO:0016057
name: regulation of membrane potential in photoreceptor cell
namespace: biological_process
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
intersection_of: GO:0042391 ! regulation of membrane potential
intersection_of: occurs_in CL:0000210 ! photoreceptor cell
relationship: occurs_in CL:0000210 ! photoreceptor cell

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_prokaryote
synonym: "RNA metabolism" EXACT []
is_a: GO:0090304 ! nucleic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33697 ! ribonucleic acid
relationship: has_primary_input_or_output CHEBI:33697 ! ribonucleic acid

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: process_has_causal_agent GO:0031982 ! vesicle
relationship: process_has_causal_agent GO:0031982 ! vesicle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25421" xsd:anyURI

[Term]
id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014706 ! striated muscle tissue development
relationship: regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0016301
name: kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
synonym: "phosphokinase activity" EXACT []
xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm"
xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016310
name: phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]
subset: goslim_chembl
subset: goslim_metagenomics
xref: Wikipedia:Phosphorylation
is_a: GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0045132 ! meiotic chromosome segregation
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0007143 ! female meiotic nuclear division
relationship: part_of GO:0007143 ! female meiotic nuclear division

[Term]
id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
alt_id: GO:0048130
def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
synonym: "oocyte microtubule cytoskeleton organisation" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity
intersection_of: GO:0016043 ! cellular component organization
intersection_of: occurs_in CL:0000023 ! oocyte
intersection_of: results_in_organization_of GO:0015630 ! microtubule cytoskeleton
relationship: occurs_in CL:0000023 ! oocyte
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0016477
name: cell migration
namespace: biological_process
def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
xref: Wikipedia:Cell_migration
is_a: GO:0048870 ! cell motility
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24787" xsd:anyURI
property_value: RO:0002161 NCBITaxon:4890

[Term]
id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]
synonym: "down regulation of angiogenesis" EXACT []
synonym: "down-regulation of angiogenesis" EXACT []
synonym: "downregulation of angiogenesis" EXACT []
synonym: "inhibition of angiogenesis" NARROW []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001525 ! angiogenesis
relationship: negatively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]
xref: Wikipedia:Sarcoplasm
is_a: GO:0005737 ! cytoplasm
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of CL:0000187 ! muscle cell
relationship: part_of CL:0000187 ! muscle cell
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:2.-.-.-
xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2"
xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1"
xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK"
xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
subset: goslim_chembl
xref: EC:2.7.-.-
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
subset: goslim_prokaryote
subset: goslim_yeast
xref: EC:3.-.-.-
xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes"
xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation"
xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE"
xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB"
xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS"
xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP"
xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP"
xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016788
name: hydrolase activity, acting on ester bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl]
subset: goslim_chembl
synonym: "esterase activity" EXACT []
xref: EC:3.1.-.-
xref: Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid"
xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin"
xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin"
xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0017085
name: response to insecticide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]
synonym: "insecticide resistance" RELATED []
synonym: "insecticide susceptibility/resistance" RELATED []
is_a: GO:0009636 ! response to toxic substance

[Term]
id: GO:0017126
name: nucleologenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732]
synonym: "nucleolus assembly" NARROW [GOC:mah]
synonym: "nucleolus biogenesis" EXACT []
is_a: GO:0007000 ! nucleolus organization
is_a: GO:0044085 ! cellular component biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: has_primary_output GO:0005730 ! nucleolus
relationship: has_primary_output GO:0005730 ! nucleolus

[Term]
id: GO:0017145
name: stem cell division
namespace: biological_process
def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]
synonym: "stem cell renewal" EXACT []
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000034 ! stem cell
relationship: has_primary_input CL:0000034 ! stem cell
property_value: RO:0002161 NCBITaxon_Union:0000023

[Term]
id: GO:0017148
name: negative regulation of translation
namespace: biological_process
alt_id: GO:0016478
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]
synonym: "down regulation of protein biosynthetic process" EXACT []
synonym: "down-regulation of protein biosynthetic process" EXACT []
synonym: "downregulation of protein biosynthetic process" EXACT []
synonym: "inhibition of protein biosynthetic process" NARROW []
synonym: "negative regulation of protein anabolism" EXACT []
synonym: "negative regulation of protein biosynthesis" EXACT []
synonym: "negative regulation of protein biosynthetic process" EXACT []
synonym: "negative regulation of protein formation" EXACT []
synonym: "negative regulation of protein synthesis" EXACT []
synonym: "protein biosynthesis inhibitor activity" RELATED []
synonym: "protein biosynthetic process inhibitor activity" RELATED []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006412 ! translation
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0017157
name: regulation of exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006887 ! exocytosis
relationship: regulates GO:0006887 ! exocytosis

[Term]
id: GO:0018130
name: heterocycle biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]
synonym: "heterocycle anabolism" EXACT []
synonym: "heterocycle biosynthesis" EXACT []
synonym: "heterocycle formation" EXACT []
synonym: "heterocycle synthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046483 ! heterocycle metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:5686 ! heterocyclic compound
relationship: has_primary_output CHEBI:5686 ! heterocyclic compound

[Term]
id: GO:0018958
name: phenol-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
synonym: "carbolic acid metabolic process" EXACT []
synonym: "carbolic acid metabolism" EXACT []
synonym: "hydroxybenzene metabolic process" EXACT []
synonym: "hydroxybenzene metabolism" EXACT []
synonym: "phenol-containing compound metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33853 ! phenols
relationship: has_primary_input_or_output CHEBI:33853 ! phenols

[Term]
id: GO:0019098
name: reproductive behavior
namespace: biological_process
alt_id: GO:0033057
alt_id: GO:0044704
alt_id: GO:0044705
def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr]
synonym: "multi-organism reproductive behavior" NARROW []
synonym: "multicellular organism reproductive behavior" NARROW []
synonym: "reproductive behavior in a multicellular organism" EXACT []
synonym: "reproductive behaviour" EXACT []
synonym: "single-organism reproductive behavior" RELATED []
is_a: GO:0007610 ! behavior
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0007610 ! behavior
intersection_of: part_of GO:0032504 ! multicellular organism reproduction
relationship: part_of GO:0032504 ! multicellular organism reproduction
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23491" xsd:anyURI
created_by: jl
creation_date: 2012-09-19T16:01:37Z

[Term]
id: GO:0019216
name: regulation of lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "regulation of lipid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006629 ! lipid metabolic process
relationship: regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0019218
name: regulation of steroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "regulation of steroid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008202 ! steroid metabolic process
relationship: regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0019220
name: regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "regulation of phosphate metabolism" EXACT []
is_a: GO:0051174 ! regulation of phosphorus metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0019222
name: regulation of metabolic process
namespace: biological_process
alt_id: GO:0044246
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: goslim_metagenomics
synonym: "regulation of metabolism" EXACT []
synonym: "regulation of multicellular organismal metabolic process" NARROW []
synonym: "regulation of organismal metabolic process" NARROW [GOC:tb]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008152 ! metabolic process
relationship: regulates GO:0008152 ! metabolic process

[Term]
id: GO:0019226
name: transmission of nerve impulse
namespace: biological_process
def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]
synonym: "conduction of nerve impulse" EXACT [GOC:dph]
synonym: "signal transmission along a neuron" EXACT []
is_a: GO:0050877 ! nervous system process
relationship: has_part GO:0001508 ! action potential
relationship: has_part GO:0007268 ! chemical synaptic transmission
relationship: part_of GO:0007154 ! cell communication

[Term]
id: GO:0019228
name: neuronal action potential
namespace: biological_process
def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001508 ! action potential
intersection_of: GO:0001508 ! action potential
intersection_of: occurs_in CL:0000540 ! neuron
relationship: occurs_in CL:0000540 ! neuron
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019233
name: sensory perception of pain
namespace: biological_process
def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators]
synonym: "nociception" RELATED []
synonym: "perception of physiological pain" NARROW []
xref: Wikipedia:Nociception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0019318
name: hexose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:18133 ! hexose
relationship: has_primary_input_or_output CHEBI:18133 ! hexose

[Term]
id: GO:0019319
name: hexose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose anabolism" EXACT []
synonym: "hexose biosynthesis" EXACT []
synonym: "hexose formation" EXACT []
synonym: "hexose synthesis" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:18133 ! hexose
relationship: has_primary_output CHEBI:18133 ! hexose

[Term]
id: GO:0019320
name: hexose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]
synonym: "hexose breakdown" EXACT []
synonym: "hexose catabolism" EXACT []
synonym: "hexose degradation" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:18133 ! hexose
relationship: has_primary_input CHEBI:18133 ! hexose

[Term]
id: GO:0019336
name: phenol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]
synonym: "phenol-containing compound breakdown" EXACT []
synonym: "phenol-containing compound catabolism" EXACT []
synonym: "phenol-containing compound degradation" EXACT []
xref: MetaCyc:PHENOLDEG-PWY
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901616 ! organic hydroxy compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33853 ! phenols
relationship: has_primary_input CHEBI:33853 ! phenols

[Term]
id: GO:0019413
name: acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate anabolism" EXACT []
synonym: "acetate biosynthesis" EXACT []
synonym: "acetate formation" EXACT []
synonym: "acetate synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072330 ! monocarboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:30089 ! acetate
relationship: has_primary_output CHEBI:30089 ! acetate

[Term]
id: GO:0019438
name: aromatic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
synonym: "aromatic compound anabolism" EXACT []
synonym: "aromatic compound biosynthesis" EXACT []
synonym: "aromatic compound formation" EXACT []
synonym: "aromatic compound synthesis" EXACT []
synonym: "aromatic hydrocarbon biosynthesis" NARROW []
synonym: "aromatic hydrocarbon biosynthetic process" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33655 ! aromatic compound
relationship: has_primary_output CHEBI:33655 ! aromatic compound

[Term]
id: GO:0019439
name: aromatic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
synonym: "aromatic compound breakdown" EXACT []
synonym: "aromatic compound catabolism" EXACT []
synonym: "aromatic compound degradation" EXACT []
synonym: "aromatic hydrocarbon catabolic process" NARROW []
synonym: "aromatic hydrocarbon catabolism" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044248 ! cellular catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33655 ! aromatic compound
relationship: has_primary_input CHEBI:33655 ! aromatic compound

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
alt_id: GO:0044267
alt_id: GO:0044268
def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_plant
synonym: "cellular protein metabolic process" EXACT []
synonym: "cellular protein metabolism" EXACT []
synonym: "multicellular organismal protein metabolic process" NARROW []
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0044238 ! primary metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output PR:000000001 ! protein
relationship: has_primary_input_or_output PR:000000001 ! protein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0019614
name: catechol-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
synonym: "catechol breakdown" RELATED []
synonym: "catechol catabolic process" RELATED []
synonym: "catechol catabolism" RELATED []
synonym: "catechol degradation" RELATED []
is_a: GO:0009712 ! catechol-containing compound metabolic process
is_a: GO:0019336 ! phenol-containing compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33566 ! catechols
relationship: has_primary_input CHEBI:33566 ! catechols

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_plant
is_a: GO:0042592 ! homeostatic process
intersection_of: GO:0042592 ! homeostatic process
intersection_of: occurs_in CL:0000000 ! cell
disjoint_from: GO:0048872 ! homeostasis of number of cells
relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms
relationship: occurs_in CL:0000000 ! cell
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
synonym: "secondary metabolism" EXACT []
synonym: "secondary metabolite metabolic process" EXACT []
synonym: "secondary metabolite metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "carboxylic acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:29067 ! carboxylic acid anion
relationship: has_primary_input_or_output CHEBI:29067 ! carboxylic acid anion

[Term]
id: GO:0019755
name: one-carbon compound transport
namespace: biological_process
def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "one carbon compound transport" EXACT []
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:64708 ! one-carbon compound
relationship: has_primary_input CHEBI:64708 ! one-carbon compound

[Term]
id: GO:0019827
name: stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]
synonym: "maintenance of pluripotency" RELATED [GOC:vk]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0098727 ! maintenance of cell number
intersection_of: GO:0098727 ! maintenance of cell number
intersection_of: acts_on_population_of CL:0000034 ! stem cell
relationship: acts_on_population_of CL:0000034 ! stem cell

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
subset: goslim_metagenomics
is_a: GO:0016020 ! membrane

[Term]
id: GO:0019882
name: antigen processing and presentation
namespace: biological_process
alt_id: GO:0030333
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
synonym: "antigen presentation" EXACT []
synonym: "antigen processing" EXACT []
xref: Wikipedia:Antigen_presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019953
name: sexual reproduction
namespace: biological_process
def: "A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction]
comment: Note that gametes may come from two organisms or from a single organism in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. Note also that sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.
xref: Wikipedia:Sexual_reproduction
is_a: GO:0000003 ! reproduction
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22929" xsd:anyURI

[Term]
id: GO:0021501
name: prechordal plate formation
namespace: biological_process
def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003063 ! prechordal plate
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_formation_of_anatomical_entity UBERON:0003063 ! prechordal plate

[Term]
id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002240 ! spinal cord
relationship: part_of GO:0007417 ! central nervous system development
relationship: results_in_development_of UBERON:0002240 ! spinal cord

[Term]
id: GO:0021514
name: ventral spinal cord interneuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: occurs_in UBERON:0002240 ! spinal cord
intersection_of: results_in_acquisition_of_features_of CL:0000099 ! interneuron
relationship: part_of GO:0021517 ! ventral spinal cord development
relationship: results_in_acquisition_of_features_of CL:0000099 ! interneuron

[Term]
id: GO:0021515
name: cell differentiation in spinal cord
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: occurs_in UBERON:0002240 ! spinal cord
relationship: occurs_in UBERON:0002240 ! spinal cord
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021517
name: ventral spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002257 ! ventral horn of spinal cord
relationship: part_of GO:0021510 ! spinal cord development
relationship: results_in_development_of UBERON:0002257 ! ventral horn of spinal cord

[Term]
id: GO:0021522
name: spinal cord motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0021953 ! central nervous system neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0011001 ! spinal cord motor neuron
relationship: part_of GO:0021517 ! ventral spinal cord development
relationship: results_in_acquisition_of_features_of CL:0011001 ! spinal cord motor neuron

[Term]
id: GO:0021523
name: somatic motor neuron differentiation
namespace: biological_process
def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0021522 ! spinal cord motor neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0005024 ! somatomotor neuron
relationship: results_in_acquisition_of_features_of CL:0005024 ! somatomotor neuron

[Term]
id: GO:0021532
name: neural tube patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0021533
name: cell differentiation in hindbrain
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: occurs_in UBERON:0002028 ! hindbrain
relationship: in_taxon NCBITaxon:89593 {all_only="true"} ! Craniata <chordates>
relationship: occurs_in UBERON:0002028 ! hindbrain
relationship: only_in_taxon NCBITaxon:89593 ! Craniata <chordates>
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021534
name: cell proliferation in hindbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: occurs_in UBERON:0002028 ! hindbrain
relationship: in_taxon NCBITaxon:89593 {all_only="true"} ! Craniata <chordates>
relationship: occurs_in UBERON:0002028 ! hindbrain
relationship: only_in_taxon NCBITaxon:89593 ! Craniata <chordates>
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021535
name: cell migration in hindbrain
namespace: biological_process
def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: occurs_in UBERON:0002028 ! hindbrain
relationship: in_taxon NCBITaxon:89593 {all_only="true"} ! Craniata <chordates>
relationship: occurs_in UBERON:0002028 ! hindbrain
relationship: only_in_taxon NCBITaxon:89593 ! Craniata <chordates>
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021545
name: cranial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021675 ! nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001785 ! cranial nerve
relationship: results_in_development_of UBERON:0001785 ! cranial nerve

[Term]
id: GO:0021546
name: rhombomere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001892 ! rhombomere
relationship: part_of GO:0030902 ! hindbrain development
relationship: results_in_development_of UBERON:0001892 ! rhombomere

[Term]
id: GO:0021547
name: midbrain-hindbrain boundary initiation
namespace: biological_process
def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513]
synonym: "isthmus biosynthesis" RELATED [GOC:cls]
synonym: "isthmus formation" RELATED [GOC:cls]
synonym: "MHB biosynthesis" EXACT [GOC:cls]
synonym: "MHB formation" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls]
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003052 ! midbrain-hindbrain boundary
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development
relationship: results_in_formation_of_anatomical_entity UBERON:0003052 ! midbrain-hindbrain boundary

[Term]
id: GO:0021548
name: pons development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000988 ! pons
relationship: part_of GO:0022037 ! metencephalon development
relationship: results_in_development_of UBERON:0000988 ! pons

[Term]
id: GO:0021550
name: medulla oblongata development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla development" RELATED [GOC:cls]
synonym: "myelencephalon development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001896 ! medulla oblongata
relationship: part_of GO:0030902 ! hindbrain development
relationship: results_in_development_of UBERON:0001896 ! medulla oblongata

[Term]
id: GO:0021551
name: central nervous system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001017 ! central nervous system
relationship: part_of GO:0007417 ! central nervous system development
relationship: results_in_morphogenesis_of UBERON:0001017 ! central nervous system

[Term]
id: GO:0021555
name: midbrain-hindbrain boundary morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus morphogenesis" EXACT [GOC:cls]
synonym: "MHB morphogenesis" EXACT [GOC:cls]
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003052 ! midbrain-hindbrain boundary
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development
relationship: results_in_morphogenesis_of UBERON:0003052 ! midbrain-hindbrain boundary

[Term]
id: GO:0021556
name: central nervous system formation
namespace: biological_process
def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001017 ! central nervous system
relationship: part_of GO:0021551 ! central nervous system morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001017 ! central nervous system

[Term]
id: GO:0021559
name: trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V development" RELATED [GOC:cls]
synonym: "cranial nerve 5 development" EXACT [GOC:cls]
synonym: "cranial nerve V development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001645 ! trigeminal nerve
relationship: results_in_development_of UBERON:0001645 ! trigeminal nerve

[Term]
id: GO:0021575
name: hindbrain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "rhombencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002028 ! hindbrain
relationship: part_of GO:0030902 ! hindbrain development
relationship: results_in_morphogenesis_of UBERON:0002028 ! hindbrain

[Term]
id: GO:0021576
name: hindbrain formation
namespace: biological_process
def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002028 ! hindbrain
relationship: part_of GO:0021575 ! hindbrain morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002028 ! hindbrain

[Term]
id: GO:0021578
name: hindbrain maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0002028 ! hindbrain
relationship: part_of GO:0021626 ! central nervous system maturation
relationship: part_of GO:0030902 ! hindbrain development
relationship: results_in_maturation_of UBERON:0002028 ! hindbrain

[Term]
id: GO:0021579
name: medulla oblongata morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla morphogenesis" RELATED []
synonym: "myelencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001896 ! medulla oblongata
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021575 ! hindbrain morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001896 ! medulla oblongata

[Term]
id: GO:0021580
name: medulla oblongata formation
namespace: biological_process
def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla biosynthesis" RELATED []
synonym: "medulla formation" RELATED []
synonym: "myelencephalon biosynthesis" RELATED []
synonym: "myelencephalon formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001896 ! medulla oblongata
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001896 ! medulla oblongata

[Term]
id: GO:0021582
name: medulla oblongata maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "medulla maturation" RELATED []
synonym: "myelencephalon maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001896 ! medulla oblongata
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021578 ! hindbrain maturation
relationship: results_in_maturation_of UBERON:0001896 ! medulla oblongata

[Term]
id: GO:0021583
name: pons morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000988 ! pons
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021575 ! hindbrain morphogenesis
relationship: results_in_morphogenesis_of UBERON:0000988 ! pons

[Term]
id: GO:0021584
name: pons formation
namespace: biological_process
def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000988 ! pons
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000988 ! pons

[Term]
id: GO:0021586
name: pons maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0000988 ! pons
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021578 ! hindbrain maturation
relationship: results_in_maturation_of UBERON:0000988 ! pons

[Term]
id: GO:0021593
name: rhombomere morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001892 ! rhombomere
relationship: part_of GO:0021546 ! rhombomere development
relationship: results_in_morphogenesis_of UBERON:0001892 ! rhombomere

[Term]
id: GO:0021594
name: rhombomere formation
namespace: biological_process
def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001892 ! rhombomere
relationship: part_of GO:0021593 ! rhombomere morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001892 ! rhombomere

[Term]
id: GO:0021602
name: cranial nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001785 ! cranial nerve
relationship: part_of GO:0021545 ! cranial nerve development
relationship: results_in_morphogenesis_of UBERON:0001785 ! cranial nerve

[Term]
id: GO:0021603
name: cranial nerve formation
namespace: biological_process
def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001785 ! cranial nerve
relationship: part_of GO:0021602 ! cranial nerve morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001785 ! cranial nerve

[Term]
id: GO:0021605
name: cranial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0021682 ! nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001785 ! cranial nerve
relationship: part_of GO:0021545 ! cranial nerve development
relationship: results_in_maturation_of UBERON:0001785 ! cranial nerve

[Term]
id: GO:0021626
name: central nervous system maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001017 ! central nervous system
relationship: part_of GO:0007417 ! central nervous system development
relationship: results_in_maturation_of UBERON:0001017 ! central nervous system

[Term]
id: GO:0021635
name: trigeminal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001645 ! trigeminal nerve
relationship: part_of GO:0021559 ! trigeminal nerve development
relationship: results_in_maturation_of UBERON:0001645 ! trigeminal nerve

[Term]
id: GO:0021636
name: trigeminal nerve morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001645 ! trigeminal nerve
relationship: part_of GO:0021559 ! trigeminal nerve development
relationship: results_in_morphogenesis_of UBERON:0001645 ! trigeminal nerve

[Term]
id: GO:0021638
name: trigeminal nerve formation
namespace: biological_process
def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "CN V biosynthesis" RELATED []
synonym: "CN V formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001645 ! trigeminal nerve
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001645 ! trigeminal nerve

[Term]
id: GO:0021654
name: rhombomere boundary formation
namespace: biological_process
def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0018239 ! rhombomere boundary
relationship: part_of GO:0021594 ! rhombomere formation
relationship: results_in_formation_of_anatomical_entity UBERON:0018239 ! rhombomere boundary

[Term]
id: GO:0021675
name: nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001021 ! nerve
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_development_of UBERON:0001021 ! nerve

[Term]
id: GO:0021682
name: nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001021 ! nerve
relationship: part_of GO:0021675 ! nerve development
relationship: results_in_maturation_of UBERON:0001021 ! nerve

[Term]
id: GO:0021700
name: developmental maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
subset: goslim_chembl
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0021703
name: locus ceruleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "locus caeruleus development" EXACT []
synonym: "locus coeruleus development" EXACT []
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002148 ! locus ceruleus
relationship: part_of GO:0021548 ! pons development
relationship: results_in_development_of UBERON:0002148 ! locus ceruleus

[Term]
id: GO:0021704
name: locus ceruleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002148 ! locus ceruleus
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021703 ! locus ceruleus development
relationship: results_in_morphogenesis_of UBERON:0002148 ! locus ceruleus

[Term]
id: GO:0021705
name: locus ceruleus formation
namespace: biological_process
def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002148 ! locus ceruleus
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021704 ! locus ceruleus morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002148 ! locus ceruleus

[Term]
id: GO:0021706
name: locus ceruleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0002148 ! locus ceruleus
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021703 ! locus ceruleus development
relationship: results_in_maturation_of UBERON:0002148 ! locus ceruleus

[Term]
id: GO:0021718
name: superior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0007247 ! nucleus of superior olivary complex
relationship: part_of GO:0021548 ! pons development
relationship: results_in_development_of UBERON:0007247 ! nucleus of superior olivary complex

[Term]
id: GO:0021719
name: superior olivary nucleus morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007247 ! nucleus of superior olivary complex
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021718 ! superior olivary nucleus development
relationship: results_in_morphogenesis_of UBERON:0007247 ! nucleus of superior olivary complex

[Term]
id: GO:0021720
name: superior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0007247 ! nucleus of superior olivary complex
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0007247 ! nucleus of superior olivary complex

[Term]
id: GO:0021722
name: superior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
synonym: "superior olive maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0007247 ! nucleus of superior olivary complex
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021718 ! superior olivary nucleus development
relationship: results_in_maturation_of UBERON:0007247 ! nucleus of superior olivary complex

[Term]
id: GO:0021732
name: midbrain-hindbrain boundary maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513]
synonym: "isthmus maturation" RELATED []
synonym: "MHB maturation" RELATED []
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0003052 ! midbrain-hindbrain boundary
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development
relationship: results_in_maturation_of UBERON:0003052 ! midbrain-hindbrain boundary

[Term]
id: GO:0021751
name: salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048857 ! neural nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004133 ! salivatory nucleus
relationship: part_of GO:0021548 ! pons development
relationship: results_in_development_of UBERON:0004133 ! salivatory nucleus

[Term]
id: GO:0021753
name: superior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0021751 ! salivary nucleus development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002149 ! superior salivatory nucleus
relationship: results_in_development_of UBERON:0002149 ! superior salivatory nucleus

[Term]
id: GO:0021782
name: glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000125 ! glial cell
relationship: part_of GO:0010001 ! glial cell differentiation
relationship: results_in_development_of CL:0000125 ! glial cell

[Term]
id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
is_a: GO:0048859 ! formation of anatomical boundary
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005076 ! hindbrain-spinal cord boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning
relationship: results_in_formation_of_anatomical_entity UBERON:0005076 ! hindbrain-spinal cord boundary

[Term]
id: GO:0021915
name: neural tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001049 ! neural tube
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: results_in_development_of UBERON:0001049 ! neural tube

[Term]
id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:2000029 ! central nervous system neuron
relationship: part_of GO:0007417 ! central nervous system development
relationship: results_in_acquisition_of_features_of CL:2000029 ! central nervous system neuron

[Term]
id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:2000029 ! central nervous system neuron
relationship: part_of GO:0021953 ! central nervous system neuron differentiation
relationship: results_in_development_of CL:2000029 ! central nervous system neuron

[Term]
id: GO:0021990
name: neural plate formation
namespace: biological_process
def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003075 ! neural plate
relationship: part_of GO:0001839 ! neural plate morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003075 ! neural plate

[Term]
id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0022008
name: neurogenesis
namespace: biological_process
def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
synonym: "nervous system cell generation" EXACT systematic_synonym []
synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph]
xref: Wikipedia:Neurogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001570 ! vasculogenesis
intersection_of: GO:0001570 ! vasculogenesis
intersection_of: results_in_maturation_of UBERON:0001017 ! central nervous system
relationship: results_in_maturation_of UBERON:0001017 ! central nervous system
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21480" xsd:anyURI

[Term]
id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700]
is_a: GO:0021535 ! cell migration in hindbrain
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_transport_to_from_or_in UBERON:0001892 ! rhombomere
relationship: part_of GO:0021546 ! rhombomere development
relationship: results_in_transport_to_from_or_in UBERON:0001892 ! rhombomere

[Term]
id: GO:0022037
name: metencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001895 ! metencephalon
relationship: part_of GO:0030902 ! hindbrain development
relationship: results_in_development_of UBERON:0001895 ! metencephalon

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0007049 ! cell cycle
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098609 ! cell-cell adhesion
relationship: regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "down regulation of cell-cell adhesion" EXACT []
synonym: "down-regulation of cell-cell adhesion" EXACT []
synonym: "downregulation of cell-cell adhesion" EXACT []
synonym: "inhibition of cell-cell adhesion" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098609 ! cell-cell adhesion
relationship: negatively_regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "activation of cell-cell adhesion" NARROW []
synonym: "stimulation of cell-cell adhesion" NARROW []
synonym: "up regulation of cell-cell adhesion" EXACT []
synonym: "up-regulation of cell-cell adhesion" EXACT []
synonym: "upregulation of cell-cell adhesion" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098609 ! cell-cell adhesion
relationship: positively_regulates GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
alt_id: GO:0071845
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
subset: goslim_pir
synonym: "cell structure disassembly" EXACT []
synonym: "cellular component disassembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_disassembly_of GO:0005575 ! cellular_component
disjoint_from: GO:0022607 ! cellular component assembly
relationship: results_in_disassembly_of GO:0005575 ! cellular_component

[Term]
id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]
synonym: "reproductive cellular process in multicellular organism" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0032504 ! multicellular organism reproduction
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
alt_id: GO:0044702
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: goslim_generic
synonym: "single organism reproductive process" RELATED []
is_a: GO:0008150 ! biological process
intersection_of: GO:0008150 ! biological process
intersection_of: part_of GO:0000003 ! reproduction
relationship: part_of GO:0000003 ! reproduction
created_by: jl
creation_date: 2012-09-19T15:56:06Z

[Term]
id: GO:0022600
name: digestive system process
namespace: biological_process
def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]
subset: goslim_generic
is_a: GO:0003008 ! system process
intersection_of: GO:0003008 ! system process
intersection_of: part_of GO:0007586 ! digestion
relationship: part_of GO:0007586 ! digestion

[Term]
id: GO:0022602
name: ovulation cycle process
namespace: biological_process
def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete]
synonym: "estrous cycle process" RELATED []
synonym: "menstrual cycle process" RELATED []
is_a: GO:0022414 ! reproductive process
is_a: GO:0048511 ! rhythmic process
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0042698 ! ovulation cycle

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]
synonym: "regulation of morphogenesis" EXACT []
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis
relationship: regulates GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]
synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000902 ! cell morphogenesis
relationship: regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
alt_id: GO:0071844
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: goslim_chembl
subset: goslim_pir
synonym: "cell structure assembly" EXACT []
synonym: "cellular component assembly at cellular level" EXACT []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_assembly_of GO:0005575 ! cellular_component
relationship: part_of GO:0044085 ! cellular component biogenesis
relationship: results_in_assembly_of GO:0005575 ! cellular_component

[Term]
id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002530 ! gland
relationship: part_of GO:0048732 ! gland development
relationship: results_in_morphogenesis_of UBERON:0002530 ! gland

[Term]
id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]
synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah]
synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022617
name: extracellular matrix disassembly
namespace: biological_process
def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0031012 ! extracellular matrix
relationship: results_in_disassembly_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0022618
name: protein-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
subset: goslim_chembl
synonym: "ribonucleoprotein complex assembly" EXACT []
synonym: "RNA-protein complex assembly" EXACT []
synonym: "RNP complex assembly" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071826 ! protein-RNA complex organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex

[Term]
id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
synonym: "active carrier activity" EXACT []
synonym: "carrier activity" EXACT []
synonym: "permease activity" EXACT []
synonym: "pump activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022853
name: active monoatomic ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
synonym: "active ion transmembrane transporter activity" BROAD []
is_a: GO:0015075 ! monoatomic ion transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity
intersection_of: GO:0022804 ! active transmembrane transporter activity
intersection_of: has_primary_input CHEBI:24867 ! monoatomic ion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI

[Term]
id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005386
alt_id: GO:0015563
alt_id: GO:0015646
alt_id: GO:0022891
alt_id: GO:0022892
def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "substrate-specific transmembrane transporter activity" RELATED []
synonym: "substrate-specific transporter activity" RELATED []
synonym: "uptake permease activity" RELATED []
synonym: "uptake transmembrane transporter activity" RELATED []
xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61"
xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate"
xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate"
xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA"
xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome"
xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: part_of GO:0055085 ! transmembrane transport
relationship: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:33694 ! biomacromolecule
relationship: has_primary_input CHEBI:33694 ! biomacromolecule

[Term]
id: GO:0022890
name: inorganic cation transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015077
alt_id: GO:0015082
alt_id: GO:0072509
alt_id: GO:0072510
def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah]
synonym: "divalent inorganic cation transmembrane transporter activity" NARROW []
synonym: "monovalent inorganic cation transmembrane transporter activity" NARROW []
synonym: "trivalent inorganic cation transmembrane transporter activity" NARROW []
is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:36915 ! inorganic cation
relationship: has_primary_input CHEBI:36915 ! inorganic cation

[Term]
id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
subset: gocheck_do_not_annotate
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022857 ! transmembrane transporter activity
relationship: regulates GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0023019
name: signal transduction involved in regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0010468 ! regulation of gene expression
relationship: part_of GO:0010468 ! regulation of gene expression
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023051
name: regulation of signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "regulation of signaling process" RELATED [GOC:bf]
synonym: "regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0023052 ! signaling
relationship: regulates GO:0023052 ! signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023052
name: signaling
namespace: biological_process
alt_id: GO:0023046
alt_id: GO:0044700
def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_mouse
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "biological signaling" EXACT []
synonym: "signaling process" EXACT []
synonym: "signalling" EXACT []
synonym: "signalling process" RELATED [GOC:mah]
synonym: "single organism signaling" RELATED []
is_a: GO:0050789 ! regulation of biological process
created_by: jl
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023056
name: positive regulation of signaling
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "positive regulation of signaling process" RELATED [GOC:bf]
synonym: "positive regulation of signalling process" EXACT [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0023052 ! signaling
relationship: positively_regulates GO:0023052 ! signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023057
name: negative regulation of signaling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
synonym: "negative regulation of signaling process" RELATED [GOC:bf]
synonym: "negative regulation of signalling process" RELATED [GOC:mah]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0023052 ! signaling
relationship: negatively_regulates GO:0023052 ! signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0023061
name: signal release
namespace: biological_process
def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal]
synonym: "signal secretion" EXACT [GOC:bf]
is_a: GO:0032940 ! secretion by cell
intersection_of: GO:0032940 ! secretion by cell
intersection_of: part_of GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007267 ! cell-cell signaling
creation_date: 2010-02-16T09:30:50Z

[Term]
id: GO:0030001
name: metal ion transport
namespace: biological_process
alt_id: GO:0070838
alt_id: GO:0070839
def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "divalent metal ion export" NARROW []
synonym: "divalent metal ion transport" NARROW []
synonym: "heavy metal ion transport" NARROW []
synonym: "metal ion export" NARROW []
is_a: GO:0006812 ! monoatomic cation transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:25213 ! metal cation
relationship: has_primary_input CHEBI:25213 ! metal cation
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23033" xsd:anyURI
created_by: mah
creation_date: 2009-07-31T01:07:46Z

[Term]
id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
alt_id: GO:0000283
alt_id: GO:0030468
def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
synonym: "bud site selection/establishment of cell polarity" NARROW []
synonym: "cell polarization" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
xref: Wikipedia:Myofibril
is_a: GO:0043292 ! contractile fiber
intersection_of: GO:0043292 ! contractile fiber
intersection_of: part_of CL:0000737 ! striated muscle cell
relationship: part_of CL:0000737 ! striated muscle cell

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
xref: Wikipedia:Sarcomere
is_a: GO:0110165 ! cellular anatomical entity
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0030029
name: actin filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "microfilament-based process" RELATED []
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: process_has_causal_agent GO:0005884 ! actin filament
relationship: process_has_causal_agent GO:0005884 ! actin filament

[Term]
id: GO:0030030
name: cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_prokaryote
synonym: "cell projection organisation" EXACT []
synonym: "cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0042995 ! cell projection
relationship: results_in_organization_of GO:0042995 ! cell projection
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26279" xsd:anyURI

[Term]
id: GO:0030031
name: cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
synonym: "cell projection biogenesis" RELATED [GOC:mah]
synonym: "formation of a cell surface projection" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0042995 ! cell projection
relationship: results_in_assembly_of GO:0042995 ! cell projection

[Term]
id: GO:0030033
name: microvillus assembly
namespace: biological_process
def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]
synonym: "microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005902 ! microvillus
relationship: results_in_assembly_of GO:0005902 ! microvillus

[Term]
id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pombe
synonym: "actin cytoskeleton organisation" EXACT []
synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "actin modulating activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0030029 ! actin filament-based process
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0015629 ! actin cytoskeleton
relationship: results_in_organization_of GO:0015629 ! actin cytoskeleton
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23114" xsd:anyURI

[Term]
id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]
is_a: GO:0030029 ! actin filament-based process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI

[Term]
id: GO:0030050
name: vesicle transport along actin filament
namespace: biological_process
def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input GO:0031982 ! vesicle
intersection_of: results_in_transport_along GO:0005884 ! actin filament

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
xref: Wikipedia:Cell_junction
is_a: GO:0110165 ! cellular anatomical entity
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0030072
name: peptide hormone secretion
namespace: biological_process
def: "The regulated release of a peptide hormone from a cell." [GOC:mah]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:25905 ! peptide hormone
relationship: has_primary_input CHEBI:25905 ! peptide hormone

[Term]
id: GO:0030073
name: insulin secretion
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732]
is_a: GO:0009306 ! protein secretion
is_a: GO:0030072 ! peptide hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input PR:000009054 ! insulin gene translation product
relationship: has_primary_input PR:000009054 ! insulin gene translation product
relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045" xsd:anyURI

[Term]
id: GO:0030097
name: hemopoiesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]
synonym: "blood cell biosynthesis" EXACT []
synonym: "blood cell formation" EXACT []
synonym: "haemopoiesis" EXACT []
synonym: "hematopoiesis" EXACT []
xref: Wikipedia:Haematopoiesis
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000988 ! hematopoietic cell
relationship: results_in_development_of CL:0000988 ! hematopoietic cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22178" xsd:anyURI

[Term]
id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
alt_id: GO:0046650
def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "lymphocyte cell differentiation" EXACT []
synonym: "lymphocyte development" RELATED [GOC:add]
synonym: "lymphocytic blood cell differentiation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000542 ! lymphocyte
relationship: results_in_acquisition_of_features_of CL:0000542 ! lymphocyte

[Term]
id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000763 ! myeloid cell
relationship: part_of GO:0030097 ! hemopoiesis
relationship: results_in_acquisition_of_features_of CL:0000763 ! myeloid cell

[Term]
id: GO:0030100
name: regulation of endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006897 ! endocytosis
relationship: regulates GO:0006897 ! endocytosis

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
synonym: "constitutive secretory pathway transport vesicle" EXACT []
synonym: "Golgi to vacuole transport vesicle" NARROW []
synonym: "Golgi-vacuole transport vesicle" NARROW []
synonym: "secretory vesicle" RELATED []
xref: NIF_Subcellular:sao885490876
is_a: GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
synonym: "secretory vesicle" BROAD []
is_a: GO:0099503 ! secretory vesicle
relationship: part_of GO:0012505 ! endomembrane system
property_value: RO:0002161 NCBITaxon:4890

[Term]
id: GO:0030154
name: cell differentiation
namespace: biological_process
def: "The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_mouse
subset: goslim_plant
xref: Wikipedia:Cellular_differentiation
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0048869 ! cellular developmental process
intersection_of: results_in_acquisition_of_features_of CL:0000000 ! cell
relationship: results_in_acquisition_of_features_of CL:0000000 ! cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI

[Term]
id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
synonym: "cell adhesion receptor regulator activity" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007155 ! cell adhesion
relationship: regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
alt_id: GO:0044254
alt_id: GO:0044257
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular protein breakdown" EXACT []
synonym: "cellular protein catabolic process" EXACT []
synonym: "cellular protein catabolism" EXACT []
synonym: "cellular protein degradation" EXACT []
synonym: "multicellular organismal protein catabolic process" NARROW []
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0019538 ! protein metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input PR:000000001 ! protein
relationship: has_primary_input PR:000000001 ! protein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0030182
name: neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000540 ! neuron
relationship: part_of GO:0048699 ! generation of neurons
relationship: results_in_acquisition_of_features_of CL:0000540 ! neuron

[Term]
id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
synonym: "extracellular matrix organisation" EXACT []
synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization
is_a: GO:0045229 ! external encapsulating structure organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0031012 ! extracellular matrix
relationship: results_in_organization_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]
synonym: "collagen fibril organisation" EXACT []
synonym: "fibrillar collagen organization" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0098643 ! banded collagen fibril
relationship: results_in_organization_of GO:0098643 ! banded collagen fibril
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
synonym: "glycosaminoglycan metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:18085 ! glycosaminoglycan
relationship: has_primary_input_or_output CHEBI:18085 ! glycosaminoglycan

[Term]
id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan metabolism" EXACT []
is_a: GO:1903510 ! mucopolysaccharide metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:16336 ! hyaluronic acid
relationship: has_primary_input_or_output CHEBI:16336 ! hyaluronic acid

[Term]
id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan anabolism" EXACT []
synonym: "hyaluronan biosynthesis" EXACT []
synonym: "hyaluronan formation" EXACT []
synonym: "hyaluronan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030212 ! hyaluronan metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:16336 ! hyaluronic acid
relationship: has_primary_output CHEBI:16336 ! hyaluronic acid

[Term]
id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]
synonym: "hyaluronan breakdown" EXACT []
synonym: "hyaluronan catabolism" EXACT []
synonym: "hyaluronan degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030212 ! hyaluronan metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:16336 ! hyaluronic acid
relationship: has_primary_input CHEBI:16336 ! hyaluronic acid

[Term]
id: GO:0030217
name: T cell differentiation
namespace: biological_process
alt_id: GO:0042112
alt_id: GO:0046652
def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah]
comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development" RELATED [GOC:add]
synonym: "T lymphocyte differentiation" EXACT []
synonym: "T-cell differentiation" EXACT []
synonym: "T-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000084 ! T cell
relationship: results_in_acquisition_of_features_of CL:0000084 ! T cell

[Term]
id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]
synonym: "erythrocyte cell differentiation" EXACT []
synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph]
synonym: "RBC differentiation" EXACT [CL:0000232]
synonym: "red blood cell differentiation" EXACT [CL:0000232]
xref: Wikipedia:Erythropoiesis
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000232 ! erythrocyte
relationship: part_of GO:0034101 ! erythrocyte homeostasis
relationship: results_in_acquisition_of_features_of CL:0000232 ! erythrocyte

[Term]
id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]
synonym: "megakaryocyte cell differentiation" EXACT []
is_a: GO:0030099 ! myeloid cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000556 ! megakaryocyte
relationship: results_in_acquisition_of_features_of CL:0000556 ! megakaryocyte

[Term]
id: GO:0030239
name: myofibril assembly
namespace: biological_process
def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0097435 ! supramolecular fiber organization
is_a: GO:0140694 ! non-membrane-bounded organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0030016 ! myofibril
relationship: part_of GO:0055002 ! striated muscle cell development
relationship: results_in_assembly_of GO:0030016 ! myofibril

[Term]
id: GO:0030261
name: chromosome condensation
namespace: biological_process
alt_id: GO:0000068
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation]
synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf]
synonym: "nuclear chromosome condensation" EXACT [GOC:bf]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptotic nuclear change" NARROW []
is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
namespace: biological_process
def: "The compaction of chromatin during apoptosis." [GOC:mah]
synonym: "pyknosis" EXACT []
xref: Wikipedia:Pyknosis
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030264
name: nuclear fragmentation involved in apoptotic nuclear change
namespace: biological_process
def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]
synonym: "apoptotic nuclear fragmentation" EXACT []
synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "nucleus fragmentation" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0071763 ! nuclear membrane organization
intersection_of: part_of GO:0030262 ! apoptotic nuclear changes
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030278
name: regulation of ossification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "regulation of bone biosynthesis" EXACT []
synonym: "regulation of bone formation" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001503 ! ossification
relationship: regulates GO:0001503 ! ossification

[Term]
id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "down regulation of ossification" EXACT []
synonym: "down-regulation of ossification" EXACT []
synonym: "downregulation of ossification" EXACT []
synonym: "inhibition of ossification" NARROW []
synonym: "negative regulation of bone biosynthesis" EXACT []
synonym: "negative regulation of bone formation" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001503 ! ossification
relationship: negatively_regulates GO:0001503 ! ossification

[Term]
id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "activation of cell growth" NARROW []
synonym: "stimulation of cell growth" NARROW []
synonym: "up regulation of cell growth" EXACT []
synonym: "up-regulation of cell growth" EXACT []
synonym: "upregulation of cell growth" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016049 ! cell growth
relationship: positively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
synonym: "down regulation of cell growth" EXACT []
synonym: "down-regulation of cell growth" EXACT []
synonym: "downregulation of cell growth" EXACT []
synonym: "inhibition of cell growth" NARROW []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016049 ! cell growth
relationship: negatively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators]
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell
relationship: part_of GO:0071944 ! cell periphery

[Term]
id: GO:0030317
name: flagellated sperm motility
namespace: biological_process
alt_id: GO:0097724
alt_id: GO:1905419
def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]
synonym: "flagellated sperm movement" EXACT []
synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc]
synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT []
synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie]
synonym: "sperm motility" BROAD []
synonym: "sperm movement" BROAD []
xref: Wikipedia:Sperm_motility
is_a: GO:0060285 ! cilium-dependent cell motility
is_a: GO:0060294 ! cilium movement involved in cell motility
is_a: GO:0097722 ! sperm motility
intersection_of: GO:0060285 ! cilium-dependent cell motility
intersection_of: results_in_movement_of CL:0000019 ! sperm

[Term]
id: GO:0030323
name: respiratory tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000117 ! respiratory tube
relationship: results_in_development_of UBERON:0000117 ! respiratory tube

[Term]
id: GO:0030324
name: lung development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002048 ! lung
relationship: part_of GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development
relationship: results_in_development_of UBERON:0002048 ! lung

[Term]
id: GO:0030334
name: regulation of cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016477 ! cell migration
relationship: regulates GO:0016477 ! cell migration
property_value: RO:0002161 NCBITaxon:4890

[Term]
id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "activation of cell migration" NARROW []
synonym: "stimulation of cell migration" NARROW []
synonym: "up regulation of cell migration" EXACT []
synonym: "up-regulation of cell migration" EXACT []
synonym: "upregulation of cell migration" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016477 ! cell migration
relationship: positively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "down regulation of cell migration" EXACT []
synonym: "down-regulation of cell migration" EXACT []
synonym: "downregulation of cell migration" EXACT []
synonym: "inhibition of cell migration" NARROW []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016477 ! cell migration
relationship: negatively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030397
name: membrane disassembly
namespace: biological_process
def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]
synonym: "membrane breakdown" EXACT []
synonym: "membrane catabolism" EXACT []
synonym: "membrane degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0016020 ! membrane
relationship: results_in_disassembly_of GO:0016020 ! membrane

[Term]
id: GO:0030421
name: defecation
namespace: biological_process
def: "The expulsion of feces from the rectum." [GOC:mah]
xref: Wikipedia:Defecation
is_a: GO:0007588 ! excretion
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030432
name: peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732]
xref: Wikipedia:Peristalsis
is_a: GO:0014821 ! phasic smooth muscle contraction

[Term]
id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
alt_id: GO:0000065
def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT []
synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT []
synonym: "microtubule-dependent nuclear positioning" EXACT []
synonym: "microtubule-dependent nucleus positioning" EXACT []
synonym: "microtubule-mediated nuclear migration" EXACT []
synonym: "nuclear migration, microtubule-mediated" EXACT []
synonym: "nuclear movement, microtubule-mediated" BROAD []
synonym: "nucleus migration" BROAD []
synonym: "transport of nucleus by microtubules" EXACT []
synonym: "transport of nucleus, microtubule-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0072384 ! organelle transport along microtubule
intersection_of: GO:0007097 ! nuclear migration
intersection_of: results_in_transport_along GO:0015630 ! microtubule cytoskeleton
relationship: results_in_transport_along GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
is_a: GO:0043292 ! contractile fiber
intersection_of: GO:0043292 ! contractile fiber
intersection_of: part_of CL:0000192 ! smooth muscle cell
relationship: part_of CL:0000192 ! smooth muscle cell

[Term]
id: GO:0030539
name: male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888]
synonym: "male genital development" EXACT []
is_a: GO:0048806 ! genitalia development
is_a: GO:0061458 ! reproductive system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000079 ! male reproductive system
relationship: part_of GO:0046661 ! male sex differentiation
relationship: results_in_development_of UBERON:0000079 ! male reproductive system

[Term]
id: GO:0030573
name: bile acid catabolic process
namespace: biological_process
alt_id: GO:0019613
def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW []
synonym: "bile acid breakdown" EXACT []
synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:36235 ! bile acid anion
relationship: has_primary_input CHEBI:36235 ! bile acid anion

[Term]
id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]
synonym: "collagen breakdown" EXACT []
synonym: "collagen catabolism" EXACT []
synonym: "collagen degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0032963 ! collagen metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input GO:0005581 ! collagen trimer
relationship: has_primary_input GO:0005581 ! collagen trimer

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
synonym: "constitutive secretory pathway transport vesicle membrane" EXACT []
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0030133 ! transport vesicle
relationship: bounding_layer_of GO:0030133 ! transport vesicle
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
is_a: GO:0012506 ! vesicle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0031410 ! cytoplasmic vesicle
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
synonym: "Golgi vesicle membrane" RELATED []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005798 ! Golgi-associated vesicle
relationship: bounding_layer_of GO:0005798 ! Golgi-associated vesicle
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0030141 ! secretory granule
relationship: bounding_layer_of GO:0030141 ! secretory granule
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber
relationship: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber

[Term]
id: GO:0030718
name: germ-line stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]
is_a: GO:0019827 ! stem cell population maintenance
intersection_of: GO:0098727 ! maintenance of cell number
intersection_of: acts_on_population_of CL:0000014 ! germ line stem cell
relationship: acts_on_population_of CL:0000014 ! germ line stem cell

[Term]
id: GO:0030720
name: oocyte localization involved in germarium-derived egg chamber formation
namespace: biological_process
def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT []
synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT []
synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah]
synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte localization during oogenesis" RELATED []
synonym: "oocyte positioning during oogenesis" NARROW []
synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT []
synonym: "oogenesis, oocyte localization" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051674 ! localization of cell
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input CL:0000023 ! oocyte
relationship: has_primary_input CL:0000023 ! oocyte
relationship: in_taxon NCBITaxon:50557 {all_only="true"} ! Insecta
relationship: only_in_taxon NCBITaxon:50557 ! Insecta
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000066 ! epithelial cell
relationship: part_of GO:0060429 ! epithelium development
relationship: results_in_acquisition_of_features_of CL:0000066 ! epithelial cell

[Term]
id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030855 ! epithelial cell differentiation
relationship: regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of epithelial cell differentiation" EXACT []
synonym: "down-regulation of epithelial cell differentiation" EXACT []
synonym: "downregulation of epithelial cell differentiation" EXACT []
synonym: "inhibition of epithelial cell differentiation" NARROW []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030855 ! epithelial cell differentiation
relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "activation of epithelial cell differentiation" NARROW []
synonym: "stimulation of epithelial cell differentiation" NARROW []
synonym: "up regulation of epithelial cell differentiation" EXACT []
synonym: "up-regulation of epithelial cell differentiation" EXACT []
synonym: "upregulation of epithelial cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030855 ! epithelial cell differentiation
relationship: positively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030901
name: midbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]
synonym: "mesencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001891 ! midbrain
relationship: part_of GO:0007420 ! brain development
relationship: results_in_development_of UBERON:0001891 ! midbrain

[Term]
id: GO:0030902
name: hindbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain]
synonym: "rhombencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002028 ! hindbrain
relationship: part_of GO:0007420 ! brain development
relationship: results_in_development_of UBERON:0002028 ! hindbrain

[Term]
id: GO:0030903
name: notochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]
is_a: GO:0048568 ! embryonic organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002328 ! notochord
relationship: results_in_development_of UBERON:0002328 ! notochord

[Term]
id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]
synonym: "isthmic organizer development" EXACT []
synonym: "isthmomesencephalic boundary development" EXACT []
synonym: "isthmus development" EXACT []
synonym: "MHB development" EXACT []
synonym: "midbrain-hindbrain orgainizer development" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003052 ! midbrain-hindbrain boundary
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning
relationship: results_in_development_of UBERON:0003052 ! midbrain-hindbrain boundary

[Term]
id: GO:0030936
name: transmembrane collagen trimer
namespace: cellular_component
def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976]
synonym: "MACIT" EXACT [ISBN:0198599587]
is_a: GO:0005581 ! collagen trimer
is_a: GO:0098797 ! plasma membrane protein complex
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]
synonym: "cytoskeleton polarization" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030990
name: intraciliary transport particle
namespace: cellular_component
def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]
comment: Note that we deem cilia and microtubule-based flagella to be equivalent.
subset: goslim_pir
synonym: "IFT complex" RELATED []
synonym: "intraflagellar transport complex" EXACT []
synonym: "intraflagellar transport particle" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: capable_of_part_of GO:0035735 ! intraciliary transport involved in cilium assembly

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
alt_id: GO:0005578
def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
synonym: "matrisome" NARROW []
synonym: "proteinaceous extracellular matrix" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090513
xref: Wikipedia:Extracellular_matrix
is_a: GO:0030312 ! external encapsulating structure
disjoint_from: GO:0032991 ! protein-containing complex
disjoint_from: GO:0043226 ! organelle

[Term]
id: GO:0031016
name: pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones." [GOC:cvs]
xref: Wikipedia:Pancreas
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001264 ! pancreas
relationship: results_in_development_of UBERON:0001264 ! pancreas
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23777" xsd:anyURI

[Term]
id: GO:0031017
name: exocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000017 ! exocrine pancreas
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035272 ! exocrine system development
relationship: part_of GO:0055123 ! digestive system development
relationship: results_in_development_of UBERON:0000017 ! exocrine pancreas

[Term]
id: GO:0031018
name: endocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000016 ! endocrine pancreas
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035270 ! endocrine system development
relationship: results_in_development_of UBERON:0000016 ! endocrine pancreas

[Term]
id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]
synonym: "nuclear migration, microfilament-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0099515 ! actin filament-based transport
intersection_of: GO:0007097 ! nuclear migration
intersection_of: results_in_transport_along GO:0005884 ! actin filament

[Term]
id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
synonym: "actomyosin organization" EXACT []
synonym: "actomyosin structure organisation" EXACT []
synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0042641 ! actomyosin
relationship: results_in_organization_of GO:0042641 ! actomyosin

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]
synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv]
xref: NIF_Subcellular:sao772007592
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "embryonic eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]
synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606]
xref: NIF_Subcellular:sao830981606
is_a: GO:0016020 ! membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031109
name: microtubule polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
synonym: "microtubule dynamics" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23195" xsd:anyURI

[Term]
id: GO:0031110
name: regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031111
name: negative regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "downregulation of microtubule polymerization or depolymerization" EXACT []
synonym: "inhibition of microtubule polymerization or depolymerization" NARROW []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031112
name: positive regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "activation of microtubule polymerization or depolymerization" NARROW []
synonym: "stimulation of microtubule polymerization or depolymerization" NARROW []
synonym: "up regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "upregulation of microtubule polymerization or depolymerization" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization
relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031113
name: regulation of microtubule polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah]
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046785 ! microtubule polymerization
relationship: regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031114
name: regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "regulation of microtubule disassembly" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:1901879 ! regulation of protein depolymerization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007019 ! microtubule depolymerization
relationship: regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031115
name: negative regulation of microtubule polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization" EXACT []
synonym: "down-regulation of microtubule polymerization" EXACT []
synonym: "downregulation of microtubule polymerization" EXACT []
synonym: "inhibition of microtubule polymerization" NARROW []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046785 ! microtubule polymerization
relationship: negatively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031116
name: positive regulation of microtubule polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "activation of microtubule polymerization" NARROW []
synonym: "stimulation of microtubule polymerization" NARROW []
synonym: "up regulation of microtubule polymerization" EXACT []
synonym: "up-regulation of microtubule polymerization" EXACT []
synonym: "upregulation of microtubule polymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046785 ! microtubule polymerization
relationship: positively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031117
name: positive regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "activation of microtubule depolymerization" NARROW []
synonym: "microtubule destabilization" EXACT []
synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of microtubule disassembly" EXACT []
synonym: "stimulation of microtubule depolymerization" NARROW []
synonym: "up regulation of microtubule depolymerization" EXACT []
synonym: "up-regulation of microtubule depolymerization" EXACT []
synonym: "upregulation of microtubule depolymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:1901881 ! positive regulation of protein depolymerization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007019 ! microtubule depolymerization
relationship: positively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031122
name: cytoplasmic microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
synonym: "cytoplasmic microtubule organisation" EXACT []
synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005881 ! cytoplasmic microtubule
relationship: results_in_organization_of GO:0005881 ! cytoplasmic microtubule

[Term]
id: GO:0031128
name: developmental induction
namespace: biological_process
def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535]
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment
relationship: has_part GO:0045168 ! cell-cell signaling involved in cell fate commitment
property_value: RO:0002161 NCBITaxon:4895

[Term]
id: GO:0031175
name: neuron projection development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite development" NARROW [GOC:dph]
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite outgrowth" NARROW []
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: part_of GO:0048666 ! neuron development
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]
synonym: "membrane extension" RELATED []
synonym: "membrane projection" RELATED []
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0120025 ! plasma membrane bounded cell projection
relationship: bounding_layer_of GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0031323
name: regulation of cellular metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "regulation of cellular metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044237 ! cellular metabolic process
relationship: regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031324
name: negative regulation of cellular metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular metabolic process" EXACT []
synonym: "down-regulation of cellular metabolic process" EXACT []
synonym: "downregulation of cellular metabolic process" EXACT []
synonym: "inhibition of cellular metabolic process" NARROW []
synonym: "negative regulation of cellular metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process
relationship: negatively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031325
name: positive regulation of cellular metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of cellular metabolic process" NARROW []
synonym: "positive regulation of cellular metabolism" EXACT []
synonym: "stimulation of cellular metabolic process" NARROW []
synonym: "up regulation of cellular metabolic process" EXACT []
synonym: "up-regulation of cellular metabolic process" EXACT []
synonym: "upregulation of cellular metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044237 ! cellular metabolic process
relationship: positively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031326
name: regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
synonym: "regulation of cellular anabolism" EXACT []
synonym: "regulation of cellular biosynthesis" EXACT []
synonym: "regulation of cellular formation" EXACT []
synonym: "regulation of cellular synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044249 ! cellular biosynthetic process
relationship: regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031327
name: negative regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
synonym: "down regulation of cellular biosynthetic process" EXACT []
synonym: "down-regulation of cellular biosynthetic process" EXACT []
synonym: "downregulation of cellular biosynthetic process" EXACT []
synonym: "inhibition of cellular biosynthetic process" NARROW []
synonym: "negative regulation of cellular anabolism" EXACT []
synonym: "negative regulation of cellular biosynthesis" EXACT []
synonym: "negative regulation of cellular formation" EXACT []
synonym: "negative regulation of cellular synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process
relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031328
name: positive regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
synonym: "activation of cellular biosynthetic process" NARROW []
synonym: "positive regulation of cellular anabolism" EXACT []
synonym: "positive regulation of cellular biosynthesis" EXACT []
synonym: "positive regulation of cellular formation" EXACT []
synonym: "positive regulation of cellular synthesis" EXACT []
synonym: "stimulation of cellular biosynthetic process" NARROW []
synonym: "up regulation of cellular biosynthetic process" EXACT []
synonym: "up-regulation of cellular biosynthetic process" EXACT []
synonym: "upregulation of cellular biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process
relationship: positively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031329
name: regulation of cellular catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
synonym: "regulation of cellular breakdown" EXACT []
synonym: "regulation of cellular catabolism" EXACT []
synonym: "regulation of cellular degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044248 ! cellular catabolic process
relationship: regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031330
name: negative regulation of cellular catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
synonym: "down regulation of cellular catabolic process" EXACT []
synonym: "down-regulation of cellular catabolic process" EXACT []
synonym: "downregulation of cellular catabolic process" EXACT []
synonym: "inhibition of cellular catabolic process" NARROW []
synonym: "negative regulation of cellular breakdown" EXACT []
synonym: "negative regulation of cellular catabolism" EXACT []
synonym: "negative regulation of cellular degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process
relationship: negatively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031331
name: positive regulation of cellular catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
synonym: "activation of cellular catabolic process" NARROW []
synonym: "positive regulation of cellular breakdown" EXACT []
synonym: "positive regulation of cellular catabolism" EXACT []
synonym: "positive regulation of cellular degradation" EXACT []
synonym: "stimulation of cellular catabolic process" NARROW []
synonym: "up regulation of cellular catabolic process" EXACT []
synonym: "up-regulation of cellular catabolic process" EXACT []
synonym: "upregulation of cellular catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044248 ! cellular catabolic process
relationship: positively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031333
name: negative regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "down regulation of protein complex assembly" EXACT []
synonym: "down-regulation of protein complex assembly" EXACT []
synonym: "downregulation of protein complex assembly" EXACT []
synonym: "inhibition of protein complex assembly" NARROW []
synonym: "negative regulation of protein complex assembly" RELATED []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0065003 ! protein-containing complex assembly
relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0031334
name: positive regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
synonym: "activation of protein complex assembly" NARROW []
synonym: "positive regulation of protein complex assembly" RELATED []
synonym: "stimulation of protein complex assembly" NARROW []
synonym: "up regulation of protein complex assembly" EXACT []
synonym: "up-regulation of protein complex assembly" EXACT []
synonym: "upregulation of protein complex assembly" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0065003 ! protein-containing complex assembly
relationship: positively_regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0031338
name: regulation of vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006906 ! vesicle fusion
relationship: regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031339
name: negative regulation of vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "down regulation of vesicle fusion" EXACT []
synonym: "down-regulation of vesicle fusion" EXACT []
synonym: "downregulation of vesicle fusion" EXACT []
synonym: "inhibition of vesicle fusion" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006906 ! vesicle fusion
relationship: negatively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031340
name: positive regulation of vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "activation of vesicle fusion" NARROW []
synonym: "stimulation of vesicle fusion" NARROW []
synonym: "up regulation of vesicle fusion" EXACT []
synonym: "up-regulation of vesicle fusion" EXACT []
synonym: "upregulation of vesicle fusion" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006906 ! vesicle fusion
relationship: positively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031344
name: regulation of cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "regulation of cell projection organisation" EXACT []
synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030030 ! cell projection organization
relationship: regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031345
name: negative regulation of cell projection organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "down regulation of cell projection organization" EXACT [GOC:mah]
synonym: "down-regulation of cell projection organization" EXACT []
synonym: "downregulation of cell projection organization" EXACT []
synonym: "inhibition of cell projection organization" NARROW []
synonym: "negative regulation of cell projection organisation" EXACT []
synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030030 ! cell projection organization
relationship: negatively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031346
name: positive regulation of cell projection organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "activation of cell projection organization" NARROW []
synonym: "positive regulation of cell projection organisation" EXACT []
synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell projection organization" NARROW []
synonym: "up regulation of cell projection organization" EXACT []
synonym: "up-regulation of cell projection organization" EXACT []
synonym: "upregulation of cell projection organization" EXACT []
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030030 ! cell projection organization
relationship: positively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031347
name: regulation of defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]
is_a: GO:0080134 ! regulation of response to stress
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006952 ! defense response
relationship: regulates GO:0006952 ! defense response

[Term]
id: GO:0031348
name: negative regulation of defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "down regulation of defense response" EXACT []
synonym: "down-regulation of defense response" EXACT []
synonym: "downregulation of defense response" EXACT []
synonym: "inhibition of defense response" NARROW []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006952 ! defense response
relationship: negatively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031349
name: positive regulation of defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "activation of defense response" NARROW []
synonym: "stimulation of defense response" NARROW []
synonym: "up regulation of defense response" EXACT []
synonym: "up-regulation of defense response" EXACT []
synonym: "upregulation of defense response" EXACT []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006952 ! defense response
relationship: positively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
alt_id: GO:0016023
def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]
subset: goslim_agr
subset: goslim_candida
subset: goslim_chembl
subset: goslim_generic
subset: goslim_mouse
subset: goslim_yeast
synonym: "cytoplasmic membrane bounded vesicle" RELATED []
synonym: "cytoplasmic membrane-enclosed vesicle" RELATED []
synonym: "cytoplasmic, membrane-bounded vesicle" RELATED []
xref: NIF_Subcellular:sao180601769
is_a: GO:0097708 ! intracellular vesicle
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0031503
name: protein-containing complex localization
namespace: biological_process
alt_id: GO:0034629
def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "cellular protein complex localisation" RELATED [GOC:mah]
synonym: "cellular protein complex localization" RELATED []
synonym: "cellular protein-containing complex localization" RELATED []
synonym: "establishment and maintenance of cellular protein complex localization" RELATED []
synonym: "establishment and maintenance of protein complex localization" EXACT []
synonym: "protein complex localisation" EXACT [GOC:mah]
synonym: "protein complex localization" RELATED []
is_a: GO:0051179 ! localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0032991 ! protein-containing complex
relationship: has_primary_input GO:0032991 ! protein-containing complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI

[Term]
id: GO:0031514
name: motile cilium
namespace: cellular_component
alt_id: GO:0009434
alt_id: GO:0031512
def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]
synonym: "microtubule-based flagellum" RELATED []
synonym: "motile cilia" EXACT []
synonym: "motile primary cilia" RELATED []
synonym: "motile primary cilium" RELATED []
synonym: "motile secondary cilium" RELATED []
synonym: "nodal cilium" RELATED []
is_a: GO:0005929 ! cilium
intersection_of: GO:0005929 ! cilium
intersection_of: capable_of GO:0003341 ! cilium movement
relationship: capable_of GO:0003341 ! cilium movement

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512]
synonym: "NMJ" RELATED [GOC:ha]
xref: NIF_Subcellular:sao1124888485
xref: Wikipedia:Neuromuscular_junction
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: overlaps CL:0000100 ! motor neuron
intersection_of: overlaps CL:0000187 ! muscle cell
relationship: overlaps CL:0000100 ! motor neuron
relationship: overlaps CL:0000187 ! muscle cell

[Term]
id: GO:0031644
name: regulation of nervous system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurological system process" EXACT []
synonym: "regulation of neurophysiological process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050877 ! nervous system process
relationship: regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031645
name: negative regulation of nervous system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of neurological process" EXACT []
synonym: "down-regulation of neurological process" EXACT []
synonym: "downregulation of neurological process" EXACT []
synonym: "inhibition of neurological process" NARROW []
synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of neurological system process" EXACT []
synonym: "negative regulation of neurophysiological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050877 ! nervous system process
relationship: negatively_regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031646
name: positive regulation of nervous system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of neurological process" NARROW []
synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of neurological system process" EXACT []
synonym: "positive regulation of neurophysiological process" EXACT []
synonym: "stimulation of neurological process" NARROW []
synonym: "up regulation of neurological process" EXACT []
synonym: "up-regulation of neurological process" EXACT []
synonym: "upregulation of neurological process" EXACT []
is_a: GO:0031644 ! regulation of nervous system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050877 ! nervous system process
relationship: positively_regulates GO:0050877 ! nervous system process

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
xref: NIF_Subcellular:sao1687101204
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: goslim_mouse
is_a: GO:0031975 ! envelope
relationship: part_of GO:0043227 ! membrane-bounded organelle
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0043226 ! organelle
intersection_of: part_of GO:0031967 ! organelle envelope
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]
is_a: GO:0110165 ! cellular anatomical entity
disjoint_from: GO:0045202 ! synapse

[Term]
id: GO:0031975
name: envelope
namespace: cellular_component
def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz]
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
alt_id: GO:0031988
def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]
subset: goslim_pir
synonym: "membrane-bounded vesicle" RELATED []
synonym: "membrane-enclosed vesicle" RELATED []
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031987
name: locomotion involved in locomotory behavior
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
synonym: "locomotion during locomotory behaviour" EXACT []
is_a: GO:0040011 ! locomotion
intersection_of: GO:0040011 ! locomotion
intersection_of: part_of GO:0007626 ! locomotory behavior
relationship: part_of GO:0007626 ! locomotory behavior

[Term]
id: GO:0032024
name: positive regulation of insulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]
synonym: "activation of insulin secretion" NARROW []
synonym: "stimulation of insulin secretion" NARROW []
synonym: "up regulation of insulin secretion" EXACT []
synonym: "up-regulation of insulin secretion" EXACT []
synonym: "upregulation of insulin secretion" EXACT []
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030073 ! insulin secretion
relationship: positively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0032057
name: negative regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation initiation in response to stress" EXACT []
synonym: "down-regulation of translation initiation in response to stress" EXACT []
synonym: "downregulation of translation initiation in response to stress" EXACT []
synonym: "inhibition of translation initiation in response to stress" NARROW []
is_a: GO:0045947 ! negative regulation of translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006413 ! translational initiation
intersection_of: part_of GO:0006950 ! response to stress
relationship: part_of GO:0006950 ! response to stress

[Term]
id: GO:0032058
name: positive regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation initiation in response to stress" NARROW []
synonym: "stimulation of translation initiation in response to stress" NARROW []
synonym: "up regulation of translation initiation in response to stress" EXACT []
synonym: "up-regulation of translation initiation in response to stress" EXACT []
synonym: "upregulation of translation initiation in response to stress" EXACT []
is_a: GO:0045948 ! positive regulation of translational initiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: part_of GO:0006950 ! response to stress
intersection_of: positively_regulates GO:0006413 ! translational initiation
relationship: part_of GO:0006950 ! response to stress

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
subset: goslim_pir
synonym: "plasma membrane bleb" EXACT [GOC:pr]
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0032060
name: bleb assembly
namespace: biological_process
def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
synonym: "blebbing" BROAD [GOC:pr]
synonym: "cell blebbing" EXACT []
synonym: "membrane blebbing" BROAD [GOC:pr]
synonym: "plasma membrane bleb assembly" EXACT [GOC:pr]
synonym: "plasma membrane blebbing" EXACT [GOC:pr]
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0032059 ! bleb
relationship: results_in_assembly_of GO:0032059 ! bleb

[Term]
id: GO:0032069
name: regulation of nuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "nuclease regulator activity" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004518 ! nuclease activity
relationship: regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032070
name: regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "deoxyribonuclease regulator" RELATED []
synonym: "DNase regulator" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004536 ! DNA nuclease activity
relationship: regulates GO:0004536 ! DNA nuclease activity

[Term]
id: GO:0032074
name: negative regulation of nuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of nuclease activity" EXACT []
synonym: "down-regulation of nuclease activity" EXACT []
synonym: "downregulation of nuclease activity" EXACT []
synonym: "inhibition of nuclease activity" NARROW []
synonym: "nuclease inhibitor" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051346 ! negative regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004518 ! nuclease activity
relationship: negatively_regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032075
name: positive regulation of nuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of nuclease activity" NARROW []
synonym: "nuclease activator" RELATED []
synonym: "stimulation of nuclease activity" NARROW []
synonym: "up regulation of nuclease activity" EXACT []
synonym: "up-regulation of nuclease activity" EXACT []
synonym: "upregulation of nuclease activity" EXACT []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051345 ! positive regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004518 ! nuclease activity
relationship: positively_regulates GO:0004518 ! nuclease activity

[Term]
id: GO:0032076
name: negative regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "deoxyribonuclease inhibitor" RELATED []
synonym: "DNase inhibitor" RELATED []
synonym: "down regulation of deoxyribonuclease activity" EXACT []
synonym: "down-regulation of deoxyribonuclease activity" EXACT []
synonym: "downregulation of deoxyribonuclease activity" EXACT []
synonym: "inhibition of deoxyribonuclease activity" NARROW []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0051053 ! negative regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0004536 ! DNA nuclease activity
relationship: negatively_regulates GO:0004536 ! DNA nuclease activity

[Term]
id: GO:0032077
name: positive regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activator" RELATED []
synonym: "DNase activator" RELATED []
synonym: "stimulation of deoxyribonuclease activity" NARROW []
synonym: "up regulation of deoxyribonuclease activity" EXACT []
synonym: "up-regulation of deoxyribonuclease activity" EXACT []
synonym: "upregulation of deoxyribonuclease activity" EXACT []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0051054 ! positive regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0004536 ! DNA nuclease activity
relationship: positively_regulates GO:0004536 ! DNA nuclease activity

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009605 ! response to external stimulus
relationship: regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009605 ! response to external stimulus
relationship: negatively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009605 ! response to external stimulus
relationship: positively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
synonym: "dense core vesicle membrane" EXACT [GOC:kmv]
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0031045 ! dense core granule
relationship: bounding_layer_of GO:0031045 ! dense core granule
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0032222
name: regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032223
name: negative regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "down regulation of synaptic transmission, cholinergic" EXACT []
synonym: "down-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "downregulation of synaptic transmission, cholinergic" EXACT []
synonym: "inhibition of synaptic transmission, cholinergic" NARROW []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032224
name: positive regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "activation of synaptic transmission, cholinergic" NARROW []
synonym: "stimulation of synaptic transmission, cholinergic" NARROW []
synonym: "up regulation of synaptic transmission, cholinergic" EXACT []
synonym: "up-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "upregulation of synaptic transmission, cholinergic" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007271 ! synaptic transmission, cholinergic
relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032231
name: regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0110053 ! regulation of actin filament organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051017 ! actin filament bundle assembly
relationship: regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032232
name: negative regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "down regulation of actin filament bundle formation" EXACT []
synonym: "down-regulation of actin filament bundle formation" EXACT []
synonym: "downregulation of actin filament bundle formation" EXACT []
synonym: "inhibition of actin filament bundle formation" NARROW []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051017 ! actin filament bundle assembly
relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032233
name: positive regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "activation of actin filament bundle formation" NARROW []
synonym: "stimulation of actin filament bundle formation" NARROW []
synonym: "up regulation of actin filament bundle formation" EXACT []
synonym: "up-regulation of actin filament bundle formation" EXACT []
synonym: "upregulation of actin filament bundle formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051017 ! actin filament bundle assembly
relationship: positively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032239
name: regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015931 ! nucleobase-containing compound transport
relationship: regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032240
name: negative regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015931 ! nucleobase-containing compound transport
relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032241
name: positive regulation of nucleobase-containing compound transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb]
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase-containing compound transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015931 ! nucleobase-containing compound transport
relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport

[Term]
id: GO:0032252
name: secretory granule localization
namespace: biological_process
def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "secretory granule clustering" RELATED []
synonym: "secretory granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0030141 ! secretory granule
relationship: has_primary_input GO:0030141 ! secretory granule

[Term]
id: GO:0032253
name: dense core granule localization
namespace: biological_process
def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "dense core granule clustering" RELATED []
synonym: "dense core granule localisation" EXACT [GOC:mah]
synonym: "dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032252 ! secretory granule localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0031045 ! dense core granule
relationship: has_primary_input GO:0031045 ! dense core granule

[Term]
id: GO:0032271
name: regulation of protein polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "regulation of protein polymerisation" EXACT []
is_a: GO:0043254 ! regulation of protein-containing complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051258 ! protein polymerization
relationship: regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032272
name: negative regulation of protein polymerization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "down regulation of protein polymerization" EXACT []
synonym: "down-regulation of protein polymerization" EXACT []
synonym: "downregulation of protein polymerization" EXACT []
synonym: "inhibition of protein polymerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051258 ! protein polymerization
relationship: negatively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032273
name: positive regulation of protein polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "activation of protein polymerization" NARROW []
synonym: "stimulation of protein polymerization" NARROW []
synonym: "up regulation of protein polymerization" EXACT []
synonym: "up-regulation of protein polymerization" EXACT []
synonym: "upregulation of protein polymerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051258 ! protein polymerization
relationship: positively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032330
name: regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002062 ! chondrocyte differentiation
relationship: regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032331
name: negative regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "down regulation of chondrocyte differentiation" EXACT []
synonym: "down-regulation of chondrocyte differentiation" EXACT []
synonym: "downregulation of chondrocyte differentiation" EXACT []
synonym: "inhibition of chondrocyte differentiation" NARROW []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0061037 ! negative regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002062 ! chondrocyte differentiation
relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032332
name: positive regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "activation of chondrocyte differentiation" NARROW []
synonym: "stimulation of chondrocyte differentiation" NARROW []
synonym: "up regulation of chondrocyte differentiation" EXACT []
synonym: "up-regulation of chondrocyte differentiation" EXACT []
synonym: "upregulation of chondrocyte differentiation" EXACT []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0061036 ! positive regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002062 ! chondrocyte differentiation
relationship: positively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032365
name: intracellular lipid transport
namespace: biological_process
def: "The directed movement of lipids within cells." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18059 ! lipid
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0032368
name: regulation of lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006869 ! lipid transport
relationship: regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032369
name: negative regulation of lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of lipid transport" EXACT []
synonym: "down-regulation of lipid transport" EXACT []
synonym: "downregulation of lipid transport" EXACT []
synonym: "inhibition of lipid transport" NARROW []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:1905953 ! negative regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006869 ! lipid transport
relationship: negatively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032370
name: positive regulation of lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of lipid transport" NARROW []
synonym: "stimulation of lipid transport" NARROW []
synonym: "up regulation of lipid transport" EXACT []
synonym: "up-regulation of lipid transport" EXACT []
synonym: "upregulation of lipid transport" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:1905954 ! positive regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006869 ! lipid transport
relationship: positively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032377
name: regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032365 ! intracellular lipid transport
relationship: regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032378
name: negative regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "down regulation of intracellular lipid transport" EXACT []
synonym: "down-regulation of intracellular lipid transport" EXACT []
synonym: "downregulation of intracellular lipid transport" EXACT []
synonym: "inhibition of intracellular lipid transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032387 ! negative regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032365 ! intracellular lipid transport
relationship: negatively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032379
name: positive regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "activation of intracellular lipid transport" NARROW []
synonym: "stimulation of intracellular lipid transport" NARROW []
synonym: "up regulation of intracellular lipid transport" EXACT []
synonym: "up-regulation of intracellular lipid transport" EXACT []
synonym: "upregulation of intracellular lipid transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032388 ! positive regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032365 ! intracellular lipid transport
relationship: positively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032386
name: regulation of intracellular transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046907 ! intracellular transport
relationship: regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032387
name: negative regulation of intracellular transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "down regulation of intracellular transport" EXACT []
synonym: "down-regulation of intracellular transport" EXACT []
synonym: "downregulation of intracellular transport" EXACT []
synonym: "inhibition of intracellular transport" NARROW []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046907 ! intracellular transport
relationship: negatively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032388
name: positive regulation of intracellular transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "activation of intracellular transport" NARROW []
synonym: "stimulation of intracellular transport" NARROW []
synonym: "up regulation of intracellular transport" EXACT []
synonym: "up-regulation of intracellular transport" EXACT []
synonym: "upregulation of intracellular transport" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046907 ! intracellular transport
relationship: positively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032409
name: regulation of transporter activity
namespace: biological_process
def: "Any process that modulates the activity of a transporter." [GOC:mah]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005215 ! transporter activity
relationship: regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032410
name: negative regulation of transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a transporter." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of transporter activity" EXACT []
synonym: "down-regulation of transporter activity" EXACT []
synonym: "downregulation of transporter activity" EXACT []
synonym: "inhibition of transporter activity" NARROW []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005215 ! transporter activity
relationship: negatively_regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032411
name: positive regulation of transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a transporter." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "activation of transporter activity" NARROW []
synonym: "stimulation of transporter activity" NARROW []
synonym: "up regulation of transporter activity" EXACT []
synonym: "up-regulation of transporter activity" EXACT []
synonym: "upregulation of transporter activity" EXACT []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005215 ! transporter activity
relationship: positively_regulates GO:0005215 ! transporter activity

[Term]
id: GO:0032412
name: regulation of monoatomic ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "regulation of ion transmembrane transporter activity" BROAD []
synonym: "regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015075 ! monoatomic ion transmembrane transporter activity
relationship: regulates GO:0015075 ! monoatomic ion transmembrane transporter activity

[Term]
id: GO:0032413
name: negative regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "down regulation of ion transporter activity" EXACT []
synonym: "down-regulation of ion transporter activity" EXACT []
synonym: "downregulation of ion transporter activity" EXACT []
synonym: "inhibition of ion transporter activity" NARROW []
synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015075 ! monoatomic ion transmembrane transporter activity
relationship: negatively_regulates GO:0015075 ! monoatomic ion transmembrane transporter activity

[Term]
id: GO:0032414
name: positive regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gocheck_do_not_annotate
synonym: "activation of ion transporter activity" NARROW []
synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb]
synonym: "stimulation of ion transporter activity" NARROW []
synonym: "up regulation of ion transporter activity" EXACT []
synonym: "up-regulation of ion transporter activity" EXACT []
synonym: "upregulation of ion transporter activity" EXACT []
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015075 ! monoatomic ion transmembrane transporter activity
relationship: positively_regulates GO:0015075 ! monoatomic ion transmembrane transporter activity

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
alt_id: GO:0000141
alt_id: GO:0030482
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
synonym: "actin cable" RELATED [GOC:mah]
is_a: GO:0110165 ! cellular anatomical entity
relationship: has_part GO:0005884 ! actin filament
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0044707
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
synonym: "single-multicellular organism process" RELATED []
is_a: GO:0008150 ! biological process
property_value: RO:0002161 NCBITaxon:2
property_value: RO:0002161 NCBITaxon:2157
property_value: RO:0002161 NCBITaxon:4896
property_value: RO:0002161 NCBITaxon:4932
created_by: jl
creation_date: 2012-09-19T16:07:47Z

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
alt_id: GO:0044767
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_pir
synonym: "development" NARROW []
synonym: "single-organism developmental process" RELATED []
is_a: GO:0008150 ! biological process
created_by: jl
creation_date: 2012-12-19T12:21:31Z

[Term]
id: GO:0032504
name: multicellular organism reproduction
namespace: biological_process
def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]
subset: goslim_drosophila
is_a: GO:0000003 ! reproduction
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0032528
name: microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah]
synonym: "microvillus organisation" EXACT [GOC:mah]
synonym: "microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005902 ! microvillus
relationship: results_in_organization_of GO:0005902 ! microvillus
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0032530
name: regulation of microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah]
synonym: "regulation of microvillus organisation" EXACT [GOC:mah]
synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032528 ! microvillus organization
relationship: regulates GO:0032528 ! microvillus organization

[Term]
id: GO:0032534
name: regulation of microvillus assembly
namespace: biological_process
def: "A process that modulates the formation of a microvillus." [GOC:mah]
synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030033 ! microvillus assembly
relationship: regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:0032589
name: neuron projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0043005 ! neuron projection
relationship: bounding_layer_of GO:0043005 ! neuron projection
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0032594
name: protein transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah]
synonym: "protein translocation within membrane" EXACT []
synonym: "receptor translocation within membrane" NARROW []
synonym: "receptor transport within lipid bilayer" NARROW []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0015031 ! protein transport
intersection_of: occurs_in GO:0016020 ! membrane
relationship: occurs_in GO:0016020 ! membrane

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
alt_id: GO:0062103
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]
comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study.
subset: gocheck_do_not_annotate
synonym: "double-stranded RNA biosynthesis" NARROW []
synonym: "double-stranded RNA biosynthetic process" NARROW []
synonym: "dsRNA biosynthesis" NARROW []
synonym: "dsRNA biosynthetic process" NARROW [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl]
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
intersection_of: GO:0009059 ! macromolecule biosynthetic process
intersection_of: has_primary_output CHEBI:33697 ! ribonucleic acid
relationship: has_primary_output CHEBI:33697 ! ribonucleic acid

[Term]
id: GO:0032782
name: bile acid secretion
namespace: biological_process
def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd]
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0046717 ! acid secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:36235 ! bile acid anion
relationship: has_primary_input CHEBI:36235 ! bile acid anion

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]
subset: goslim_yeast
synonym: "monocarboxylate metabolic process" EXACT []
synonym: "monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35757 ! monocarboxylic acid anion
relationship: has_primary_input_or_output CHEBI:35757 ! monocarboxylic acid anion

[Term]
id: GO:0032790
name: ribosome disassembly
namespace: biological_process
def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
synonym: "ribosome dissociation factor" RELATED []
synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391]
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005840 ! ribosome
relationship: results_in_disassembly_of GO:0005840 ! ribosome

[Term]
id: GO:0032838
name: plasma membrane bounded cell projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah]
is_a: GO:0099568 ! cytoplasmic region
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0120025 ! plasma membrane bounded cell projection
relationship: part_of GO:0120025 ! plasma membrane bounded cell projection

[Term]
id: GO:0032868
name: response to insulin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]
synonym: "response to insulin stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone
intersection_of: GO:0042221 ! response to chemical
intersection_of: has_primary_input PR:000009054 ! insulin gene translation product
relationship: has_primary_input PR:000009054 ! insulin gene translation product

[Term]
id: GO:0032871
name: regulation of karyogamy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah]
is_a: GO:1903353 ! regulation of nucleus organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000741 ! karyogamy
relationship: regulates GO:0000741 ! karyogamy

[Term]
id: GO:0032878
name: regulation of establishment or maintenance of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity
relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "regulation of localisation" EXACT [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051179 ! localization
relationship: regulates GO:0051179 ! localization

[Term]
id: GO:0032880
name: regulation of protein localization
namespace: biological_process
alt_id: GO:1903827
def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_chembl
synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein localization" EXACT []
synonym: "regulation of protein localisation" EXACT [GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008104 ! protein localization
relationship: regulates GO:0008104 ! protein localization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI
created_by: jl
creation_date: 2015-01-20T14:32:14Z

[Term]
id: GO:0032881
name: regulation of polysaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005976 ! polysaccharide metabolic process
relationship: regulates GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0032882
name: regulation of chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah]
synonym: "regulation of chitin metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006030 ! chitin metabolic process
relationship: regulates GO:0006030 ! chitin metabolic process

[Term]
id: GO:0032883
name: regulation of chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah]
synonym: "regulation of chitin anabolism" EXACT []
synonym: "regulation of chitin biosynthesis" RELATED []
synonym: "regulation of chitin formation" EXACT []
synonym: "regulation of chitin synthesis" EXACT []
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006031 ! chitin biosynthetic process
relationship: regulates GO:0006031 ! chitin biosynthetic process

[Term]
id: GO:0032885
name: regulation of polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000271 ! polysaccharide biosynthetic process
relationship: regulates GO:0000271 ! polysaccharide biosynthetic process

[Term]
id: GO:0032886
name: regulation of microtubule-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007017 ! microtubule-based process
relationship: regulates GO:0007017 ! microtubule-based process

[Term]
id: GO:0032890
name: regulation of organic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015849 ! organic acid transport
relationship: regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032891
name: negative regulation of organic acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of organic acid transport" EXACT []
synonym: "down-regulation of organic acid transport" EXACT []
synonym: "downregulation of organic acid transport" EXACT []
synonym: "inhibition of organic acid transport" NARROW []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015849 ! organic acid transport
relationship: negatively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032892
name: positive regulation of organic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "activation of organic acid transport" NARROW []
synonym: "stimulation of organic acid transport" NARROW []
synonym: "up regulation of organic acid transport" EXACT []
synonym: "up-regulation of organic acid transport" EXACT []
synonym: "upregulation of organic acid transport" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015849 ! organic acid transport
relationship: positively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032940
name: secretion by cell
namespace: biological_process
def: "The controlled release of a substance by a cell." [GOC:mah]
synonym: "cellular secretion" EXACT []
xref: Wikipedia:Secretion
is_a: GO:0046903 ! secretion
is_a: GO:0140352 ! export from cell

[Term]
id: GO:0032941
name: secretion by tissue
namespace: biological_process
def: "The controlled release of a substance by a tissue." [GOC:mah]
synonym: "expulsion of gland contents" RELATED [GOC:mah]
synonym: "tissue secretion" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032943
name: mononuclear cell proliferation
namespace: biological_process
def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "PBMC proliferation" NARROW []
synonym: "peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070661 ! leukocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000842 ! mononuclear cell
relationship: acts_on_population_of CL:0000842 ! mononuclear cell

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "regulation of PBMC proliferation" NARROW []
synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032943 ! mononuclear cell proliferation
relationship: regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "negative regulation of PBMC proliferation" NARROW []
synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032943 ! mononuclear cell proliferation
relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032946
name: positive regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "activation of mononuclear cell proliferation" NARROW []
synonym: "positive regulation of PBMC proliferation" NARROW []
synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW []
synonym: "stimulation of mononuclear cell proliferation" NARROW []
synonym: "up regulation of mononuclear cell proliferation" EXACT []
synonym: "up-regulation of mononuclear cell proliferation" EXACT []
synonym: "upregulation of mononuclear cell proliferation" EXACT []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032943 ! mononuclear cell proliferation
relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032956
name: regulation of actin cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030036 ! actin cytoskeleton organization
relationship: regulates GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0032963
name: collagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output GO:0005581 ! collagen trimer
relationship: has_primary_input_or_output GO:0005581 ! collagen trimer

[Term]
id: GO:0032964
name: collagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]
synonym: "collagen anabolism" EXACT []
synonym: "collagen biosynthesis" EXACT []
synonym: "collagen formation" EXACT []
synonym: "collagen synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0032963 ! collagen metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output GO:0005581 ! collagen trimer
relationship: has_primary_output GO:0005581 ! collagen trimer

[Term]
id: GO:0032965
name: regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "regulation of collagen anabolism" EXACT []
synonym: "regulation of collagen biosynthesis" EXACT []
synonym: "regulation of collagen formation" EXACT []
synonym: "regulation of collagen synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0010712 ! regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032964 ! collagen biosynthetic process
relationship: regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032966
name: negative regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "negative regulation of collagen anabolism" EXACT []
synonym: "negative regulation of collagen biosynthesis" EXACT []
synonym: "negative regulation of collagen formation" EXACT []
synonym: "negative regulation of collagen synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032964 ! collagen biosynthetic process
relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032967
name: positive regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "positive regulation of collagen anabolism" EXACT []
synonym: "positive regulation of collagen biosynthesis" EXACT []
synonym: "positive regulation of collagen formation" EXACT []
synonym: "positive regulation of collagen synthesis" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032964 ! collagen biosynthetic process
relationship: positively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032970
name: regulation of actin filament-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030029 ! actin filament-based process
relationship: regulates GO:0030029 ! actin filament-based process

[Term]
id: GO:0032984
name: protein-containing complex disassembly
namespace: biological_process
alt_id: GO:0034623
alt_id: GO:0043241
alt_id: GO:0043624
def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]
synonym: "cellular macromolecule complex disassembly" RELATED []
synonym: "cellular protein complex disassembly" RELATED []
synonym: "macromolecule complex disassembly" RELATED []
synonym: "protein complex disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0032991 ! protein-containing complex
relationship: results_in_disassembly_of GO:0032991 ! protein-containing complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI

[Term]
id: GO:0032986
name: protein-DNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah]
synonym: "DNA-protein complex disassembly" EXACT [GOC:mah]
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071824 ! protein-DNA complex organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0032993 ! protein-DNA complex
relationship: results_in_disassembly_of GO:0032993 ! protein-DNA complex

[Term]
id: GO:0032988
name: protein-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]
synonym: "ribonucleoprotein complex disassembly" EXACT []
synonym: "RNA-protein complex disassembly" EXACT []
synonym: "RNP complex disassembly" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly
is_a: GO:0071826 ! protein-RNA complex organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:1990904 ! ribonucleoprotein complex
relationship: results_in_disassembly_of GO:1990904 ! ribonucleoprotein complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI

[Term]
id: GO:0032989
name: cellular anatomical entity morphogenesis
namespace: biological_process
def: "The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
synonym: "cellular component morphogenesis" EXACT []
synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of GO:0110165 ! cellular anatomical entity
relationship: results_in_morphogenesis_of GO:0110165 ! cellular anatomical entity
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25496" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26249" xsd:anyURI

[Term]
id: GO:0032991
name: protein-containing complex
namespace: cellular_component
alt_id: GO:0043234
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "macromolecular complex" EXACT []
synonym: "macromolecule complex" EXACT []
synonym: "protein complex" NARROW []
synonym: "protein containing complex" EXACT []
synonym: "protein-protein complex" NARROW []
is_a: GO:0005575 ! cellular_component
is_a: PR:000050567 ! protein-containing material entity
disjoint_from: GO:0110165 ! cellular anatomical entity

[Term]
id: GO:0032993
name: protein-DNA complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah]
comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.
subset: goslim_pir
synonym: "DNA-protein complex" EXACT [GOC:mah]
is_a: GO:0032991 ! protein-containing complex
relationship: has_part CHEBI:16991 ! deoxyribonucleic acid

[Term]
id: GO:0033002
name: muscle cell proliferation
namespace: biological_process
def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]
synonym: "myocyte proliferation" EXACT []
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000187 ! muscle cell
relationship: acts_on_population_of CL:0000187 ! muscle cell

[Term]
id: GO:0033013
name: tetrapyrrole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "tetrapyrrole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:26932 ! tetrapyrrole
relationship: has_primary_input_or_output CHEBI:26932 ! tetrapyrrole

[Term]
id: GO:0033014
name: tetrapyrrole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
synonym: "tetrapyrrole anabolism" EXACT []
synonym: "tetrapyrrole biosynthesis" EXACT []
synonym: "tetrapyrrole formation" EXACT []
synonym: "tetrapyrrole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:26932 ! tetrapyrrole
relationship: has_primary_output CHEBI:26932 ! tetrapyrrole

[Term]
id: GO:0033015
name: tetrapyrrole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]
synonym: "tetrapyrrole breakdown" EXACT []
synonym: "tetrapyrrole catabolism" EXACT []
synonym: "tetrapyrrole degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:26932 ! tetrapyrrole
relationship: has_primary_input CHEBI:26932 ! tetrapyrrole

[Term]
id: GO:0033028
name: myeloid cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093]
synonym: "apoptosis of myeloid cells" EXACT []
synonym: "myeloid cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000763 ! myeloid cell
relationship: occurs_in CL:0000763 ! myeloid cell

[Term]
id: GO:0033032
name: regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033028 ! myeloid cell apoptotic process
relationship: regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033033
name: negative regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of myeloid cell apoptosis" EXACT []
synonym: "down-regulation of myeloid cell apoptosis" EXACT []
synonym: "downregulation of myeloid cell apoptosis" EXACT []
synonym: "inhibition of myeloid cell apoptosis" NARROW []
synonym: "negative regulation of myeloid cell apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033028 ! myeloid cell apoptotic process
relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033034
name: positive regulation of myeloid cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "activation of myeloid cell apoptosis" NARROW []
synonym: "positive regulation of myeloid cell apoptosis" NARROW []
synonym: "stimulation of myeloid cell apoptosis" NARROW []
synonym: "up regulation of myeloid cell apoptosis" EXACT []
synonym: "up-regulation of myeloid cell apoptosis" EXACT []
synonym: "upregulation of myeloid cell apoptosis" EXACT []
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033028 ! myeloid cell apoptotic process
relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process

[Term]
id: GO:0033036
name: macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]
subset: goslim_flybase_ribbon
synonym: "macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization

[Term]
id: GO:0033037
name: polysaccharide localization
namespace: biological_process
def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "polysaccharide localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
intersection_of: GO:0033036 ! macromolecule localization
intersection_of: has_primary_input CHEBI:18154 ! polysaccharide
relationship: has_primary_input CHEBI:18154 ! polysaccharide

[Term]
id: GO:0033043
name: regulation of organelle organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]
subset: goslim_yeast
synonym: "regulation of organelle organisation" EXACT [GOC:mah]
synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006996 ! organelle organization
relationship: regulates GO:0006996 ! organelle organization

[Term]
id: GO:0033044
name: regulation of chromosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]
synonym: "regulation of chromosome organisation" EXACT [GOC:mah]
synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051276 ! chromosome organization
relationship: regulates GO:0051276 ! chromosome organization

[Term]
id: GO:0033045
name: regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000819 ! sister chromatid segregation
relationship: regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033046
name: negative regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000819 ! sister chromatid segregation
relationship: negatively_regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033047
name: regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033045 ! regulation of sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000070 ! mitotic sister chromatid segregation
relationship: regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033048
name: negative regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation
relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033059
name: cellular pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]
is_a: GO:0009987 ! cellular process
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033157
name: regulation of intracellular protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051223 ! regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006886 ! intracellular protein transport
relationship: regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0033238
name: regulation of amine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah]
synonym: "regulation of amine metabolism" EXACT []
synonym: "regulation of cellular amine metabolic process" EXACT []
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009308 ! amine metabolic process
relationship: regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033239
name: negative regulation of amine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "negative regulation of amine metabolism" EXACT []
synonym: "negative regulation of cellular amine metabolic process" EXACT []
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009308 ! amine metabolic process
relationship: negatively_regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033240
name: positive regulation of amine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "positive regulation of amine metabolism" EXACT []
synonym: "positive regulation of cellular amine metabolic process" EXACT []
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009308 ! amine metabolic process
relationship: positively_regulates GO:0009308 ! amine metabolic process

[Term]
id: GO:0033241
name: regulation of amine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "regulation of amine breakdown" EXACT []
synonym: "regulation of amine catabolism" EXACT []
synonym: "regulation of amine degradation" EXACT []
synonym: "regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009310 ! amine catabolic process
relationship: regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033242
name: negative regulation of amine catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "negative regulation of amine breakdown" EXACT []
synonym: "negative regulation of amine catabolism" EXACT []
synonym: "negative regulation of amine degradation" EXACT []
synonym: "negative regulation of cellular amine catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009310 ! amine catabolic process
relationship: negatively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033243
name: positive regulation of amine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "positive regulation of amine breakdown" EXACT []
synonym: "positive regulation of amine catabolism" EXACT []
synonym: "positive regulation of amine degradation" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0033241 ! regulation of amine catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009310 ! amine catabolic process
relationship: positively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033278
name: cell proliferation in midbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf]
synonym: "cell proliferation in mesencephalon" EXACT []
synonym: "mesencepahalic cell proliferation" RELATED []
is_a: GO:0061351 ! neural precursor cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: occurs_in UBERON:0001891 ! midbrain
relationship: occurs_in UBERON:0001891 ! midbrain
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0033363
name: secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "secretory granule organisation" EXACT [GOC:mah]
synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0030141 ! secretory granule
relationship: part_of GO:0010256 ! endomembrane system organization
relationship: results_in_organization_of GO:0030141 ! secretory granule

[Term]
id: GO:0033365
name: protein localization to organelle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]
synonym: "protein localisation to organelle" EXACT [GOC:mah]
synonym: "protein localization in organelle" EXACT [GOC:mah]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0043226 ! organelle
relationship: has_target_end_location GO:0043226 ! organelle

[Term]
id: GO:0033366
name: protein localization to secretory granule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah]
synonym: "protein localisation in secretory granule" EXACT [GOC:mah]
synonym: "protein localization in secretory granule" EXACT []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0030141 ! secretory granule
relationship: has_target_end_location GO:0030141 ! secretory granule

[Term]
id: GO:0033371
name: T cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "T cell secretory granule organisation" EXACT [GOC:mah]
synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah]
synonym: "T lymphocyte secretory granule organization" EXACT []
synonym: "T-cell secretory granule organization" EXACT []
synonym: "T-lymphocyte secretory granule maturation" RELATED []
synonym: "T-lymphocyte secretory granule organization" EXACT []
is_a: GO:0033363 ! secretory granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: occurs_in CL:0000084 ! T cell
intersection_of: results_in_organization_of GO:0030141 ! secretory granule
relationship: occurs_in CL:0000084 ! T cell

[Term]
id: GO:0033604
name: negative regulation of catecholamine secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "down regulation of catecholamine secretion" EXACT []
synonym: "down-regulation of catecholamine secretion" EXACT []
synonym: "downregulation of catecholamine secretion" EXACT []
synonym: "inhibition of catecholamine secretion" NARROW []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050432 ! catecholamine secretion
relationship: negatively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033605
name: positive regulation of catecholamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "activation of catecholamine secretion" NARROW []
synonym: "stimulation of catecholamine secretion" NARROW []
synonym: "up regulation of catecholamine secretion" EXACT []
synonym: "up-regulation of catecholamine secretion" EXACT []
synonym: "upregulation of catecholamine secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050432 ! catecholamine secretion
relationship: positively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033673
name: negative regulation of kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "down regulation of kinase activity" EXACT []
synonym: "down-regulation of kinase activity" EXACT []
synonym: "downregulation of kinase activity" EXACT []
synonym: "inhibition of kinase activity" NARROW []
synonym: "kinase inhibitor" NARROW []
is_a: GO:0042326 ! negative regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051348 ! negative regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016301 ! kinase activity
relationship: negatively_regulates GO:0016301 ! kinase activity

[Term]
id: GO:0033674
name: positive regulation of kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "kinase activator" NARROW []
synonym: "stimulation of kinase activity" NARROW []
synonym: "up regulation of kinase activity" EXACT []
synonym: "up-regulation of kinase activity" EXACT []
synonym: "upregulation of kinase activity" EXACT []
is_a: GO:0042327 ! positive regulation of phosphorylation
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051347 ! positive regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016301 ! kinase activity
relationship: positively_regulates GO:0016301 ! kinase activity

[Term]
id: GO:0033750
name: ribosome localization
namespace: biological_process
alt_id: GO:0033753
def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "establishment of ribosome localisation" RELATED []
synonym: "establishment of ribosome localization" RELATED []
synonym: "ribosome localisation" RELATED []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0005840 ! ribosome
relationship: has_primary_input GO:0005840 ! ribosome

[Term]
id: GO:0033762
name: response to glucagon
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl]
synonym: "response to glucagon stimulus" EXACT [GOC:dos]
is_a: GO:0043434 ! response to peptide hormone
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:5391 ! glucagon
relationship: has_primary_input CHEBI:5391 ! glucagon

[Term]
id: GO:0033993
name: response to lipid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]
is_a: GO:0010033 ! response to organic substance
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:18059 ! lipid
relationship: has_primary_input CHEBI:18059 ! lipid

[Term]
id: GO:0034067
name: protein localization to Golgi apparatus
namespace: biological_process
alt_id: GO:0000042
alt_id: GO:0072600
def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]
synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah]
synonym: "establishment of protein localization in Golgi" NARROW []
synonym: "establishment of protein localization to Golgi" NARROW []
synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah]
synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah]
synonym: "protein localization in Golgi apparatus" EXACT []
synonym: "protein targeting to Golgi" RELATED []
synonym: "protein-Golgi targeting" RELATED []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005794 ! Golgi apparatus
relationship: has_target_end_location GO:0005794 ! Golgi apparatus
created_by: mah
creation_date: 2011-02-14T02:26:36Z

[Term]
id: GO:0034101
name: erythrocyte homeostasis
namespace: biological_process
def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]
synonym: "RBC homeostasis" EXACT [CL:0000232]
synonym: "red blood cell homeostasis" EXACT [CL:0000232]
is_a: GO:0002262 ! myeloid cell homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000232 ! erythrocyte
relationship: acts_on_population_of CL:0000232 ! erythrocyte

[Term]
id: GO:0034219
name: carbohydrate transmembrane transport
namespace: biological_process
def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "carbohydrate membrane transport" EXACT []
synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:16646 ! carbohydrate
intersection_of: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0034220
name: monoatomic ion transmembrane transport
namespace: biological_process
alt_id: GO:0099131
def: "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW []
synonym: "ion membrane transport" EXACT []
synonym: "ion transmembrane transport" BROAD []
synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006811 ! monoatomic ion transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:24867 ! monoatomic ion
intersection_of: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0034242
name: negative regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034248
name: regulation of amide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "regulation of amide metabolism" EXACT []
synonym: "regulation of cellular amide metabolic process" EXACT []
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043603 ! amide metabolic process
relationship: regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034249
name: negative regulation of amide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "negative regulation of amide metabolism" EXACT []
synonym: "negative regulation of cellular amide metabolic process" EXACT []
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043603 ! amide metabolic process
relationship: negatively_regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034250
name: positive regulation of amide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "positive regulation of amide metabolism" EXACT []
synonym: "positive regulation of cellular amide metabolic process" EXACT []
is_a: GO:0034248 ! regulation of amide metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043603 ! amide metabolic process
relationship: positively_regulates GO:0043603 ! amide metabolic process

[Term]
id: GO:0034251
name: regulation of amide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "regulation of amide breakdown" EXACT []
synonym: "regulation of amide catabolism" EXACT []
synonym: "regulation of amide degradation" EXACT []
synonym: "regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0034248 ! regulation of amide metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043605 ! amide catabolic process
relationship: regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034252
name: negative regulation of amide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "negative regulation of amide breakdown" EXACT []
synonym: "negative regulation of amide catabolism" EXACT []
synonym: "negative regulation of amide degradation" RELATED []
synonym: "negative regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0034249 ! negative regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043605 ! amide catabolic process
relationship: negatively_regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034253
name: positive regulation of amide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "positive regulation of amide breakdown" EXACT []
synonym: "positive regulation of amide catabolism" EXACT []
synonym: "positive regulation of amide degradation" RELATED []
synonym: "positive regulation of cellular amide catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0034251 ! regulation of amide catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043605 ! amide catabolic process
relationship: positively_regulates GO:0043605 ! amide catabolic process

[Term]
id: GO:0034284
name: response to monosaccharide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
synonym: "response to monosaccharide stimulus" EXACT [GOC:dos]
is_a: GO:0009743 ! response to carbohydrate
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:35381 ! monosaccharide
relationship: has_primary_input CHEBI:35381 ! monosaccharide

[Term]
id: GO:0034329
name: cell junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0030054 ! cell junction
relationship: results_in_assembly_of GO:0030054 ! cell junction

[Term]
id: GO:0034330
name: cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_generic
synonym: "cell junction assembly and maintenance" EXACT []
synonym: "cell junction biogenesis" RELATED []
synonym: "cell junction organisation" EXACT [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0030054 ! cell junction
relationship: results_in_organization_of GO:0030054 ! cell junction

[Term]
id: GO:0034349
name: glial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart]
synonym: "apoptosis of glia" EXACT []
synonym: "apoptosis of glial cells" EXACT []
synonym: "glia apoptosis" EXACT []
synonym: "glia programmed cell death by apoptosis" EXACT []
synonym: "glial cell apoptosis" NARROW []
synonym: "glial cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of glia by apoptosis" EXACT []
synonym: "programmed cell death of glial cells by apoptosis" EXACT []
synonym: "programmed cell death, glia" EXACT []
synonym: "programmed cell death, glial cells" EXACT []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000125 ! glial cell
relationship: occurs_in CL:0000125 ! glial cell

[Term]
id: GO:0034350
name: regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of glial cell apoptosis" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034349 ! glial cell apoptotic process
relationship: regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034351
name: negative regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "down regulation of glial cell apoptosis" EXACT []
synonym: "down-regulation of glial cell apoptosis" EXACT []
synonym: "downregulation of glial cell apoptosis" EXACT []
synonym: "inhibition of glial cell apoptosis" NARROW []
synonym: "negative regulation of glial cell apoptosis" NARROW []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043066 ! negative regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034349 ! glial cell apoptotic process
relationship: negatively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034352
name: positive regulation of glial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "activation of glial cell apoptosis" NARROW []
synonym: "positive regulation of glial cell apoptosis" NARROW []
synonym: "stimulation of glial cell apoptosis" NARROW []
synonym: "up regulation of glial cell apoptosis" EXACT []
synonym: "up-regulation of glial cell apoptosis" EXACT []
synonym: "upregulation of glial cell apoptosis" EXACT []
is_a: GO:0034350 ! regulation of glial cell apoptotic process
is_a: GO:0043065 ! positive regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034349 ! glial cell apoptotic process
relationship: positively_regulates GO:0034349 ! glial cell apoptotic process

[Term]
id: GO:0034390
name: smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]
synonym: "apoptosis of smooth muscle cells" EXACT []
synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT []
synonym: "programmed cell death, smooth muscle cells" EXACT []
synonym: "SMC apoptosis" EXACT []
synonym: "smooth muscle cell apoptosis" NARROW []
synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT []
is_a: GO:0010657 ! muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000192 ! smooth muscle cell
relationship: occurs_in CL:0000192 ! smooth muscle cell

[Term]
id: GO:0034391
name: regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "regulation of SMC apoptosis" EXACT []
synonym: "regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010660 ! regulation of muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034392
name: negative regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "down regulation of smooth muscle cell apoptosis" EXACT []
synonym: "down-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "downregulation of smooth muscle cell apoptosis" EXACT []
synonym: "inhibition of smooth muscle cell apoptosis" NARROW []
synonym: "negative regulation of SMC apoptosis" EXACT []
synonym: "negative regulation of smooth muscle cell apoptosis" NARROW []
is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034393
name: positive regulation of smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl]
synonym: "activation of smooth muscle cell apoptosis" NARROW []
synonym: "positive regulation of SMC apoptosis" EXACT []
synonym: "positive regulation of smooth muscle cell apoptosis" NARROW []
synonym: "stimulation of smooth muscle cell apoptosis" NARROW []
synonym: "up regulation of smooth muscle cell apoptosis" EXACT []
synonym: "up-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "upregulation of smooth muscle cell apoptosis" EXACT []
is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process
relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process

[Term]
id: GO:0034436
name: glycoprotein transport
namespace: biological_process
def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:1901264 ! carbohydrate derivative transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:17089 ! glycoprotein
relationship: has_primary_input CHEBI:17089 ! glycoprotein

[Term]
id: GO:0034486
name: vacuolar transmembrane transport
namespace: biological_process
def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar membrane transport" EXACT []
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: results_in_transport_across GO:0016020 ! membrane
intersection_of: results_in_transport_to_from_or_in GO:0005773 ! vacuole
relationship: results_in_transport_to_from_or_in GO:0005773 ! vacuole

[Term]
id: GO:0034487
name: vacuolar amino acid transmembrane transport
namespace: biological_process
def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "vacuolar amino acid membrane transport" EXACT []
is_a: GO:0003333 ! amino acid transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33709 ! amino acid
intersection_of: results_in_transport_across GO:0005774 ! vacuolar membrane
relationship: results_in_transport_across GO:0005774 ! vacuolar membrane

[Term]
id: GO:0034502
name: protein localization to chromosome
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]
synonym: "condensin localization to chromosome" NARROW []
synonym: "protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005694 ! chromosome
relationship: has_target_end_location GO:0005694 ! chromosome

[Term]
id: GO:0034504
name: protein localization to nucleus
namespace: biological_process
alt_id: GO:0044744
def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]
synonym: "protein localisation to nucleus" EXACT [GOC:mah]
synonym: "protein localization in cell nucleus" EXACT []
synonym: "protein localization in nucleus" EXACT [GOC:mah]
synonym: "protein targeting to nucleus" RELATED []
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005634 ! nucleus
relationship: has_target_end_location GO:0005634 ! nucleus
creation_date: 2012-11-07T15:45:54Z

[Term]
id: GO:0034641
name: cellular nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_chembl
synonym: "cellular nitrogen compound metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0034654
name: nucleobase-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_primary_output CHEBI:61120 ! nucleobase-containing molecular entity

[Term]
id: GO:0034655
name: nucleobase-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: goslim_chembl
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity
relationship: has_primary_input CHEBI:61120 ! nucleobase-containing molecular entity

[Term]
id: GO:0034672
name: anterior/posterior pattern specification involved in pronephros development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah]
synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0039017 ! pattern specification involved in pronephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0034762
name: regulation of transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of membrane transport" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055085 ! transmembrane transport
relationship: regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034763
name: negative regulation of transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane transport" EXACT []
synonym: "down-regulation of transmembrane transport" EXACT []
synonym: "downregulation of transmembrane transport" EXACT []
synonym: "inhibition of transmembrane transport" NARROW []
synonym: "negative regulation of membrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055085 ! transmembrane transport
relationship: negatively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034764
name: positive regulation of transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane transport" NARROW []
synonym: "positive regulation of membrane transport" EXACT []
synonym: "stimulation of transmembrane transport" NARROW []
synonym: "up regulation of transmembrane transport" EXACT []
synonym: "up-regulation of transmembrane transport" EXACT []
synonym: "upregulation of transmembrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055085 ! transmembrane transport
relationship: positively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034765
name: regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of ion membrane transport" EXACT []
synonym: "regulation of ion transmembrane transport" BROAD []
synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0043269 ! regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034220 ! monoatomic ion transmembrane transport
relationship: regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034766
name: negative regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane ion transport" EXACT []
synonym: "down-regulation of transmembrane ion transport" EXACT []
synonym: "downregulation of transmembrane ion transport" EXACT []
synonym: "inhibition of transmembrane ion transport" NARROW []
synonym: "negative regulation of ion membrane transport" EXACT []
synonym: "negative regulation of ion transmembrane transport" BROAD []
synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043271 ! negative regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034220 ! monoatomic ion transmembrane transport
relationship: negatively_regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034767
name: positive regulation of monoatomic ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane ion transport" NARROW []
synonym: "positive regulation of ion membrane transport" EXACT []
synonym: "positive regulation of ion transmembrane transport" BROAD []
synonym: "positive regulation of transmembrane ion transport" EXACT []
synonym: "stimulation of transmembrane ion transport" NARROW []
synonym: "up regulation of transmembrane ion transport" EXACT []
synonym: "up-regulation of transmembrane ion transport" EXACT []
synonym: "upregulation of transmembrane ion transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
is_a: GO:0043270 ! positive regulation of monoatomic ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034220 ! monoatomic ion transmembrane transport
relationship: positively_regulates GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0034769
name: basement membrane disassembly
namespace: biological_process
alt_id: GO:0060881
def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer.
synonym: "basal lamina disassembly" RELATED []
is_a: GO:0022617 ! extracellular matrix disassembly
is_a: GO:0071711 ! basement membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005604 ! basement membrane
relationship: results_in_disassembly_of GO:0005604 ! basement membrane
created_by: dph
creation_date: 2009-08-13T11:27:24Z

[Term]
id: GO:0035019
name: somatic stem cell population maintenance
namespace: biological_process
def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
is_a: GO:0019827 ! stem cell population maintenance
intersection_of: GO:0098727 ! maintenance of cell number
intersection_of: acts_on_population_of CL:0000723 ! somatic stem cell
relationship: acts_on_population_of CL:0000723 ! somatic stem cell

[Term]
id: GO:0035039
name: male pronucleus assembly
namespace: biological_process
def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001]
synonym: "male pronucleus formation" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0022414 ! reproductive process
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0001940 ! male pronucleus
relationship: part_of GO:0007338 ! single fertilization
relationship: results_in_assembly_of GO:0001940 ! male pronucleus

[Term]
id: GO:0035040
name: sperm nuclear envelope removal
namespace: biological_process
def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051081 ! nuclear membrane disassembly
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: occurs_in CL:0000019 ! sperm
relationship: occurs_in CL:0000019 ! sperm
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035045
name: sperm plasma membrane disassembly
namespace: biological_process
def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238]
synonym: "sperm plasma membrane breakdown" EXACT []
synonym: "sperm plasma membrane catabolism" EXACT []
synonym: "sperm plasma membrane degradation" EXACT []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030397 ! membrane disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0097524 ! sperm plasma membrane
relationship: part_of GO:0007338 ! single fertilization
relationship: results_in_disassembly_of GO:0097524 ! sperm plasma membrane

[Term]
id: GO:0035050
name: embryonic heart tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004141 ! heart tube
relationship: part_of GO:0007507 ! heart development
relationship: part_of GO:0048568 ! embryonic organ development
relationship: results_in_development_of UBERON:0004141 ! heart tube

[Term]
id: GO:0035051
name: cardiocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
synonym: "cardiac cell differentiation" EXACT []
synonym: "heart cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002494 ! cardiocyte
relationship: part_of GO:0007507 ! heart development
relationship: results_in_acquisition_of_features_of CL:0002494 ! cardiocyte

[Term]
id: GO:0035082
name: axoneme assembly
namespace: biological_process
alt_id: GO:0035083
alt_id: GO:0035084
def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "axoneme biogenesis" RELATED [GOC:mah]
synonym: "ciliary axoneme assembly" EXACT []
synonym: "cilium axoneme assembly" EXACT []
synonym: "cilium axoneme biogenesis" RELATED [GOC:mah]
synonym: "flagellar axoneme assembly" EXACT []
synonym: "flagellum axoneme assembly" EXACT []
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005930 ! axoneme
relationship: part_of GO:0060271 ! cilium assembly
relationship: results_in_assembly_of GO:0005930 ! axoneme

[Term]
id: GO:0035107
name: appendage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000026 ! appendage
relationship: part_of GO:0048736 ! appendage development
relationship: results_in_morphogenesis_of UBERON:0000026 ! appendage

[Term]
id: GO:0035112
name: genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf]
synonym: "genital morphogenesis" RELATED []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000990 ! reproductive system
relationship: part_of GO:0048806 ! genitalia development
relationship: results_in_morphogenesis_of UBERON:0000990 ! reproductive system

[Term]
id: GO:0035148
name: tube formation
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]
synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah]
synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000025 ! tube
relationship: part_of GO:0035239 ! tube morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000025 ! tube

[Term]
id: GO:0035190
name: syncytial nuclear migration
namespace: biological_process
def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
is_a: GO:0007097 ! nuclear migration
intersection_of: GO:0007097 ! nuclear migration
intersection_of: occurs_in CL:0000228 ! multinucleate cell
relationship: occurs_in CL:0000228 ! multinucleate cell
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0035234
name: ectopic germ cell programmed cell death
namespace: biological_process
def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
synonym: "programmed cell death of ectopic germ cells" EXACT []
synonym: "programmed cell death, ectopic germ cells" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010623 ! programmed cell death involved in cell development
intersection_of: GO:0012501 ! programmed cell death
intersection_of: occurs_in CL:0000586 ! germ cell
relationship: occurs_in CL:0000586 ! germ cell

[Term]
id: GO:0035239
name: tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000025 ! tube
relationship: part_of GO:0035295 ! tube development
relationship: results_in_morphogenesis_of UBERON:0000025 ! tube

[Term]
id: GO:0035260
name: internal genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004175 ! internal genitalia
relationship: results_in_morphogenesis_of UBERON:0004175 ! internal genitalia

[Term]
id: GO:0035261
name: external genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004176 ! external genitalia
relationship: results_in_morphogenesis_of UBERON:0004176 ! external genitalia

[Term]
id: GO:0035262
name: gonad morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000991 ! gonad
relationship: part_of GO:0008406 ! gonad development
relationship: results_in_morphogenesis_of UBERON:0000991 ! gonad

[Term]
id: GO:0035264
name: multicellular organism growth
namespace: biological_process
def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
synonym: "body growth" RELATED []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0000468 ! multicellular organism
relationship: results_in_growth_of UBERON:0000468 ! multicellular organism

[Term]
id: GO:0035265
name: organ growth
namespace: biological_process
def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0000062 ! organ
relationship: results_in_growth_of UBERON:0000062 ! organ

[Term]
id: GO:0035270
name: endocrine system development
namespace: biological_process
def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000949 ! endocrine system
relationship: results_in_development_of UBERON:0000949 ! endocrine system

[Term]
id: GO:0035272
name: exocrine system development
namespace: biological_process
def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002330 ! exocrine system
relationship: results_in_development_of UBERON:0002330 ! exocrine system

[Term]
id: GO:0035282
name: segmentation
namespace: biological_process
def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
xref: Wikipedia:Segmentation_(biology)
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0035290
name: trunk segmentation
namespace: biological_process
def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0035295
name: tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000025 ! tube
relationship: part_of GO:0007275 ! multicellular organism development
relationship: results_in_development_of UBERON:0000025 ! tube

[Term]
id: GO:0035372
name: protein localization to microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb]
synonym: "protein localisation to microtubule" EXACT [GOC:mah]
is_a: GO:0072698 ! protein localization to microtubule cytoskeleton
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005874 ! microtubule
relationship: has_target_end_location GO:0005874 ! microtubule
created_by: bf
creation_date: 2010-03-11T11:00:56Z

[Term]
id: GO:0035418
name: protein localization to synapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]
synonym: "protein localisation to synapse" EXACT [GOC:mah]
is_a: GO:1902414 ! protein localization to cell junction
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0045202 ! synapse
relationship: has_target_end_location GO:0045202 ! synapse
created_by: bf
creation_date: 2010-03-29T10:58:53Z

[Term]
id: GO:0035433
name: acetate transmembrane transport
namespace: biological_process
def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "acetate membrane transport" EXACT []
is_a: GO:0006846 ! acetate transport
is_a: GO:1905039 ! carboxylic acid transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:30089 ! acetate
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: bf
creation_date: 2010-04-08T10:59:01Z

[Term]
id: GO:0035435
name: phosphate ion transmembrane transport
namespace: biological_process
def: "The process in which a phosphate is transported across a membrane." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "phosphate ion membrane transport" EXACT []
is_a: GO:0006817 ! phosphate ion transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:35780 ! phosphate ion
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: bf
creation_date: 2010-04-08T11:24:06Z

[Term]
id: GO:0035441
name: cell migration involved in vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001570 ! vasculogenesis
relationship: part_of GO:0001570 ! vasculogenesis
created_by: bf
creation_date: 2010-04-09T03:53:01Z

[Term]
id: GO:0035556
name: intracellular signal transduction
namespace: biological_process
alt_id: GO:0007242
alt_id: GO:0007243
alt_id: GO:0023013
alt_id: GO:0023034
def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
subset: goslim_drosophila
synonym: "intracellular signal transduction pathway" NARROW []
synonym: "intracellular signaling cascade" RELATED [GOC:signaling]
synonym: "intracellular signaling pathway" RELATED []
synonym: "signal transmission via intracellular cascade" NARROW []
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
relationship: occurs_in GO:0005622 ! intracellular anatomical structure
created_by: bf
creation_date: 2010-05-14T01:14:37Z

[Term]
id: GO:0035592
name: establishment of protein localization to extracellular region
namespace: biological_process
def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]
synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "establishment of protein localization in extracellular region" EXACT []
is_a: GO:0045184 ! establishment of protein localization
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0005576 ! extracellular region
relationship: has_target_end_location GO:0005576 ! extracellular region
created_by: bf
creation_date: 2010-11-09T10:25:08Z

[Term]
id: GO:0035622
name: intrahepatic bile duct development
namespace: biological_process
def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624]
synonym: "IHBD development" EXACT [PMID:20614624]
synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624]
is_a: GO:0061009 ! common bile duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003704 ! intrahepatic bile duct
relationship: part_of GO:0001889 ! liver development
relationship: results_in_development_of UBERON:0003704 ! intrahepatic bile duct
created_by: bf
creation_date: 2010-12-08T04:10:50Z

[Term]
id: GO:0035628
name: cystic duct development
namespace: biological_process
def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct." [PMID:20614624]
is_a: GO:0061009 ! common bile duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001152 ! cystic duct
relationship: results_in_development_of UBERON:0001152 ! cystic duct
created_by: bf
creation_date: 2010-12-10T01:24:28Z

[Term]
id: GO:0035645
name: enteric smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF]
synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504]
is_a: GO:0051145 ! smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002504 ! enteric smooth muscle cell
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_acquisition_of_features_of CL:0002504 ! enteric smooth muscle cell
created_by: bf
creation_date: 2011-01-21T02:58:58Z

[Term]
id: GO:0035701
name: hematopoietic stem cell migration
namespace: biological_process
def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092]
synonym: "hemopoietic stem cell migration" EXACT [CL:0000037]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000037 ! hematopoietic stem cell
relationship: results_in_movement_of CL:0000037 ! hematopoietic stem cell
created_by: bf
creation_date: 2011-02-28T03:20:36Z

[Term]
id: GO:0035725
name: sodium ion transmembrane transport
namespace: biological_process
def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "sodium ion membrane transport" EXACT []
is_a: GO:0006814 ! sodium ion transport
is_a: GO:0098655 ! monoatomic cation transmembrane transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: has_primary_input CHEBI:29101 ! sodium(1+)
created_by: bf
creation_date: 2011-03-10T02:52:36Z

[Term]
id: GO:0035735
name: intraciliary transport involved in cilium assembly
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2]
synonym: "intraciliary transport involved in cilium morphogenesis" RELATED []
synonym: "intraflagellar transport" BROAD []
synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED []
xref: Reactome:R-HSA-5620924.2
is_a: GO:0042073 ! intraciliary transport
intersection_of: GO:0042073 ! intraciliary transport
intersection_of: part_of GO:0060271 ! cilium assembly
relationship: part_of GO:0060271 ! cilium assembly
created_by: bf
creation_date: 2011-03-17T10:55:42Z

[Term]
id: GO:0035736
name: cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0001745 ! compound eye morphogenesis
relationship: part_of GO:0001745 ! compound eye morphogenesis
created_by: bf
creation_date: 2011-03-17T10:57:03Z

[Term]
id: GO:0035778
name: pronephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069]
is_a: GO:0039014 ! cell differentiation involved in pronephros development
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000090 ! pronephric nephron tubule epithelial cell
relationship: part_of GO:0039020 ! pronephric nephron tubule development
relationship: results_in_acquisition_of_features_of CL:1000090 ! pronephric nephron tubule epithelial cell
created_by: bf
creation_date: 2011-04-04T11:07:47Z

[Term]
id: GO:0035779
name: angioblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf]
synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566]
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000566 ! angioblastic mesenchymal cell
relationship: part_of GO:0001568 ! blood vessel development
relationship: results_in_acquisition_of_features_of CL:0000566 ! angioblastic mesenchymal cell
created_by: bf
creation_date: 2011-04-04T11:10:38Z

[Term]
id: GO:0035787
name: cell migration involved in kidney development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: bf
creation_date: 2011-04-06T10:39:52Z

[Term]
id: GO:0035788
name: cell migration involved in metanephros development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf]
synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf]
is_a: GO:0035787 ! cell migration involved in kidney development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: bf
creation_date: 2011-04-06T10:42:21Z

[Term]
id: GO:0035799
name: ureter maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463]
is_a: GO:0048799 ! animal organ maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: results_in_maturation_of UBERON:0000056 ! ureter
relationship: part_of GO:0072189 ! ureter development
relationship: results_in_maturation_of UBERON:0000056 ! ureter
created_by: bf
creation_date: 2011-04-14T01:13:39Z

[Term]
id: GO:0035805
name: egg coat
namespace: cellular_component
def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408]
synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408]
synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408]
is_a: GO:0031012 ! extracellular matrix
intersection_of: GO:0031012 ! extracellular matrix
intersection_of: part_of CL:0000025 ! egg cell
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of CL:0000025 ! egg cell
created_by: bf
creation_date: 2011-04-19T02:07:23Z

[Term]
id: GO:0035809
name: regulation of urine volume
namespace: biological_process
def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf]
synonym: "regulation of urinary volume" EXACT []
synonym: "regulation of urine flow" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050878 ! regulation of body fluid levels
created_by: bf
creation_date: 2011-04-20T01:17:38Z

[Term]
id: GO:0035834
name: indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf]
synonym: "indole alkaloid metabolism" EXACT [GOC:bf]
is_a: GO:0009820 ! alkaloid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:38958 ! indole alkaloid
relationship: has_primary_input_or_output CHEBI:38958 ! indole alkaloid
created_by: bf
creation_date: 2011-05-04T03:17:44Z

[Term]
id: GO:0035835
name: indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf]
synonym: "indole alkaloid anabolism" EXACT [GOC:bf]
synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf]
synonym: "indole alkaloid formation" EXACT [GOC:bf]
synonym: "indole alkaloid synthesis" EXACT [GOC:bf]
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0035834 ! indole alkaloid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:38958 ! indole alkaloid
relationship: has_primary_output CHEBI:38958 ! indole alkaloid
created_by: bf
creation_date: 2011-05-04T03:18:31Z

[Term]
id: GO:0035844
name: cloaca development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089]
synonym: "cloacal development" EXACT [GOC:bf]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000162 ! cloaca
relationship: part_of GO:0001655 ! urogenital system development
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: results_in_development_of UBERON:0000162 ! cloaca
created_by: bf
creation_date: 2011-05-06T01:54:35Z

[Term]
id: GO:0035846
name: oviduct epithelium development
namespace: biological_process
def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube epithelium development" NARROW [GOC:yaf]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004804 ! oviduct epithelium
relationship: part_of GO:0060066 ! oviduct development
relationship: results_in_development_of UBERON:0004804 ! oviduct epithelium
created_by: bf
creation_date: 2011-05-10T10:53:05Z

[Term]
id: GO:0035847
name: uterine epithelium development
namespace: biological_process
def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf]
synonym: "uterus epithelial development" EXACT [GOC:yaf]
is_a: GO:0035846 ! oviduct epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006955 ! uterine epithelium
relationship: part_of GO:0060065 ! uterus development
relationship: results_in_development_of UBERON:0006955 ! uterine epithelium
created_by: bf
creation_date: 2011-05-10T10:57:45Z

[Term]
id: GO:0035848
name: oviduct morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000993 ! oviduct
relationship: part_of GO:0060066 ! oviduct development
relationship: results_in_morphogenesis_of UBERON:0000993 ! oviduct
created_by: bf
creation_date: 2011-05-10T11:01:20Z

[Term]
id: GO:0035850
name: epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
created_by: bf
creation_date: 2011-05-11T11:34:21Z

[Term]
id: GO:0035855
name: megakaryocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk]
synonym: "megakaryocyte cell development" EXACT [GOC:bf]
is_a: GO:0061515 ! myeloid cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0000556 ! megakaryocyte
relationship: part_of GO:0030219 ! megakaryocyte differentiation
relationship: results_in_development_of CL:0000556 ! megakaryocyte
created_by: bf
creation_date: 2011-05-13T01:28:06Z

[Term]
id: GO:0035869
name: ciliary transition zone
namespace: cellular_component
def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]
comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone.
synonym: "cilial transition zone" EXACT []
synonym: "cilium transition zone" EXACT []
synonym: "connecting cilium" RELATED []
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of GO:0005929 ! cilium
created_by: bf
creation_date: 2011-05-25T03:09:58Z

[Term]
id: GO:0035883
name: enteroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf]
is_a: GO:0002067 ! glandular epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000164 ! enteroendocrine cell
relationship: results_in_acquisition_of_features_of CL:0000164 ! enteroendocrine cell
created_by: bf
creation_date: 2011-06-06T11:48:51Z

[Term]
id: GO:0035886
name: vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954]
synonym: "vascular smooth muscle cell differentiation" EXACT []
synonym: "VSMC differentiation" EXACT [PMID:16151017]
is_a: GO:0051145 ! smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000359 ! vascular associated smooth muscle cell
relationship: part_of GO:0001944 ! vasculature development
relationship: results_in_acquisition_of_features_of CL:0000359 ! vascular associated smooth muscle cell
created_by: bf
creation_date: 2011-06-08T11:23:52Z

[Term]
id: GO:0035887
name: aortic smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl]
is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002539 ! aortic smooth muscle cell
relationship: results_in_acquisition_of_features_of CL:0002539 ! aortic smooth muscle cell
created_by: bf
creation_date: 2011-06-08T11:34:26Z

[Term]
id: GO:0035904
name: aorta development
namespace: biological_process
def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0060840 ! artery development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000947 ! aorta
relationship: results_in_development_of UBERON:0000947 ! aorta
created_by: bf
creation_date: 2011-06-24T11:00:07Z

[Term]
id: GO:0035905
name: ascending aorta development
namespace: biological_process
def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001496 ! ascending aorta
relationship: part_of GO:0035904 ! aorta development
relationship: results_in_development_of UBERON:0001496 ! ascending aorta
created_by: bf
creation_date: 2011-06-24T11:02:01Z

[Term]
id: GO:0035906
name: descending aorta development
namespace: biological_process
def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001514 ! descending aorta
relationship: part_of GO:0035904 ! aorta development
relationship: results_in_development_of UBERON:0001514 ! descending aorta
created_by: bf
creation_date: 2011-06-24T11:05:22Z

[Term]
id: GO:0035907
name: dorsal aorta development
namespace: biological_process
def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035904 ! aorta development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005805 ! dorsal aorta
relationship: results_in_development_of UBERON:0005805 ! dorsal aorta
created_by: bf
creation_date: 2011-06-24T11:07:01Z

[Term]
id: GO:0035909
name: aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000947 ! aorta
relationship: part_of GO:0035904 ! aorta development
relationship: results_in_morphogenesis_of UBERON:0000947 ! aorta
created_by: bf
creation_date: 2011-06-24T11:11:11Z

[Term]
id: GO:0035910
name: ascending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001496 ! ascending aorta
relationship: part_of GO:0035905 ! ascending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001496 ! ascending aorta
created_by: bf
creation_date: 2011-06-24T11:14:52Z

[Term]
id: GO:0035911
name: descending aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001514 ! descending aorta
relationship: part_of GO:0035906 ! descending aorta development
relationship: part_of GO:0035909 ! aorta morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001514 ! descending aorta
created_by: bf
creation_date: 2011-06-24T11:19:24Z

[Term]
id: GO:0035912
name: dorsal aorta morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014]
is_a: GO:0035909 ! aorta morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005805 ! dorsal aorta
relationship: part_of GO:0035907 ! dorsal aorta development
relationship: results_in_morphogenesis_of UBERON:0005805 ! dorsal aorta
created_by: bf
creation_date: 2011-06-24T11:22:14Z

[Term]
id: GO:0035914
name: skeletal muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000188 ! cell of skeletal muscle
relationship: part_of GO:0007519 ! skeletal muscle tissue development
relationship: results_in_acquisition_of_features_of CL:0000188 ! cell of skeletal muscle
created_by: bf
creation_date: 2011-06-24T02:36:19Z

[Term]
id: GO:0035929
name: steroid hormone secretion
namespace: biological_process
def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl]
is_a: GO:0060986 ! endocrine hormone secretion
is_a: GO:0140353 ! lipid export from cell
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:26764 ! steroid hormone
relationship: has_primary_input CHEBI:26764 ! steroid hormone
created_by: bf
creation_date: 2011-07-20T01:01:00Z

[Term]
id: GO:0035935
name: androgen secretion
namespace: biological_process
def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl]
is_a: GO:0035929 ! steroid hormone secretion
created_by: bf
creation_date: 2011-07-20T01:11:31Z

[Term]
id: GO:0035987
name: endodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332]
synonym: "endoderm cell differentiation" EXACT [CL:0000223]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000223 ! endodermal cell
relationship: part_of GO:0001706 ! endoderm formation
relationship: results_in_acquisition_of_features_of CL:0000223 ! endodermal cell
created_by: bf
creation_date: 2011-08-25T04:50:36Z

[Term]
id: GO:0035989
name: tendon development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043]
synonym: "sinew development" RELATED [UBERON:0000043]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000043 ! tendon
relationship: results_in_development_of UBERON:0000043 ! tendon
created_by: bf
creation_date: 2011-08-26T04:14:30Z

[Term]
id: GO:0035992
name: tendon formation
namespace: biological_process
def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000043 ! tendon
relationship: part_of GO:0035989 ! tendon development
relationship: results_in_formation_of_anatomical_entity UBERON:0000043 ! tendon
created_by: bf
creation_date: 2011-08-30T01:35:10Z

[Term]
id: GO:0036072
name: direct ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034]
is_a: GO:0001503 ! ossification
created_by: bf
creation_date: 2011-12-19T01:47:22Z

[Term]
id: GO:0036093
name: germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv]
is_a: GO:0008283 ! cell population proliferation
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000586 ! germ cell
relationship: acts_on_population_of CL:0000586 ! germ cell
relationship: part_of GO:0007276 ! gamete generation
created_by: bf
creation_date: 2012-01-17T04:06:27Z

[Term]
id: GO:0036099
name: female germ-line stem cell population maintenance
namespace: biological_process
def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]
is_a: GO:0030718 ! germ-line stem cell population maintenance
intersection_of: GO:0098727 ! maintenance of cell number
intersection_of: acts_on_population_of CL:0000022 ! female germ line stem cell
relationship: acts_on_population_of CL:0000022 ! female germ line stem cell
created_by: bf
creation_date: 2012-01-26T01:58:10Z

[Term]
id: GO:0036145
name: dendritic cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]
synonym: "DC homeostasis" RELATED [PMID:19176316]
is_a: GO:0001776 ! leukocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000451 ! dendritic cell
relationship: acts_on_population_of CL:0000451 ! dendritic cell
created_by: bf
creation_date: 2012-03-12T11:05:36Z

[Term]
id: GO:0036194
name: muscle cell projection
namespace: cellular_component
def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
synonym: "muscle arm" NARROW [GOC:kmv]
synonym: "myocyte projection" EXACT [CL:0000187]
synonym: "myopodia" NARROW [GOC:kmv]
is_a: GO:0120025 ! plasma membrane bounded cell projection
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: part_of CL:0000187 ! muscle cell
relationship: part_of CL:0000187 ! muscle cell
created_by: bf
creation_date: 2012-04-20T10:20:47Z

[Term]
id: GO:0036195
name: muscle cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]
is_a: GO:0031253 ! cell projection membrane
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: GO:0031253 ! cell projection membrane
intersection_of: part_of GO:0036194 ! muscle cell projection
relationship: part_of GO:0036194 ! muscle cell projection
created_by: bf
creation_date: 2012-04-20T10:21:51Z

[Term]
id: GO:0036293
name: response to decreased oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]
comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'.
synonym: "response to lowered oxygen levels" EXACT [GOC:bf]
is_a: GO:0070482 ! response to oxygen levels
created_by: bf
creation_date: 2012-07-20T01:05:46Z

[Term]
id: GO:0036304
name: umbilical cord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002331 ! umbilical cord
relationship: part_of GO:0061027 ! umbilical cord development
relationship: results_in_morphogenesis_of UBERON:0002331 ! umbilical cord
created_by: bf
creation_date: 2012-08-08T10:12:11Z

[Term]
id: GO:0036333
name: hepatocyte homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874]
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000182 ! hepatocyte
relationship: acts_on_population_of CL:0000182 ! hepatocyte
created_by: bf
creation_date: 2012-09-05T10:17:07Z

[Term]
id: GO:0036334
name: epidermal stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529]
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:1000428 ! stem cell of epidermis
relationship: acts_on_population_of CL:1000428 ! stem cell of epidermis
created_by: bf
creation_date: 2012-09-05T10:21:23Z

[Term]
id: GO:0036336
name: dendritic cell migration
namespace: biological_process
def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990]
is_a: GO:0071674 ! mononuclear cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000451 ! dendritic cell
relationship: results_in_movement_of CL:0000451 ! dendritic cell
created_by: bf
creation_date: 2012-09-05T10:24:46Z

[Term]
id: GO:0036342
name: post-anal tail morphogenesis
namespace: biological_process
def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007812 ! post-anal tail
relationship: in_taxon NCBITaxon:7711 {all_only="true"} ! Chordata
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: results_in_morphogenesis_of UBERON:0007812 ! post-anal tail
created_by: bf
creation_date: 2012-09-11T13:54:49Z

[Term]
id: GO:0036477
name: somatodendritic compartment
namespace: cellular_component
def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000540 ! neuron
created_by: bf
creation_date: 2014-07-24T10:06:19Z

[Term]
id: GO:0036484
name: trunk neural crest cell migration
namespace: biological_process
def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]
synonym: "trunk NCC migration" EXACT [PMID:2387238]
is_a: GO:0001755 ! neural crest cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000011 ! migratory trunk neural crest cell
relationship: part_of GO:0035290 ! trunk segmentation
relationship: results_in_movement_of CL:0000011 ! migratory trunk neural crest cell
created_by: bf
creation_date: 2014-08-26T15:27:44Z

[Term]
id: GO:0036504
name: Golgi membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691]
synonym: "Golgi apparatus membrane fusion" EXACT []
synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf]
synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609]
is_a: GO:0090174 ! organelle membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: results_in_fusion_of GO:0000139 ! Golgi membrane
relationship: part_of GO:0090168 ! Golgi reassembly
relationship: results_in_fusion_of GO:0000139 ! Golgi membrane
created_by: bf
creation_date: 2015-05-21T10:05:06Z

[Term]
id: GO:0039006
name: pronephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005310 ! pronephric nephron tubule
relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis
relationship: part_of GO:0072116 ! pronephros formation
relationship: results_in_formation_of_anatomical_entity UBERON:0005310 ! pronephric nephron tubule
created_by: bf
creation_date: 2010-07-02T09:37:27Z

[Term]
id: GO:0039007
name: pronephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005309 ! pronephric nephron
relationship: part_of GO:0039019 ! pronephric nephron development
relationship: part_of GO:0072114 ! pronephros morphogenesis
relationship: results_in_morphogenesis_of UBERON:0005309 ! pronephric nephron
created_by: bf
creation_date: 2010-07-02T09:38:53Z

[Term]
id: GO:0039008
name: pronephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558]
is_a: GO:0072078 ! nephron tubule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005310 ! pronephric nephron tubule
relationship: part_of GO:0039007 ! pronephric nephron morphogenesis
relationship: part_of GO:0039020 ! pronephric nephron tubule development
relationship: results_in_morphogenesis_of UBERON:0005310 ! pronephric nephron tubule
created_by: bf
creation_date: 2010-07-02T09:45:55Z

[Term]
id: GO:0039014
name: cell differentiation involved in pronephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: bf
creation_date: 2010-07-02T09:59:25Z

[Term]
id: GO:0039015
name: cell proliferation involved in pronephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10]
synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: bf
creation_date: 2010-07-02T10:01:49Z

[Term]
id: GO:0039016
name: cell-cell signaling involved in pronephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: bf
creation_date: 2010-07-02T10:03:16Z

[Term]
id: GO:0039017
name: pattern specification involved in pronephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0048793 ! pronephros development
relationship: part_of GO:0048793 ! pronephros development
created_by: bf
creation_date: 2010-07-02T10:04:39Z

[Term]
id: GO:0039019
name: pronephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785]
is_a: GO:0072006 ! nephron development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005309 ! pronephric nephron
relationship: part_of GO:0048793 ! pronephros development
relationship: results_in_development_of UBERON:0005309 ! pronephric nephron
created_by: bf
creation_date: 2010-07-02T10:10:20Z

[Term]
id: GO:0039020
name: pronephric nephron tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568]
is_a: GO:0072080 ! nephron tubule development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005310 ! pronephric nephron tubule
relationship: part_of GO:0039019 ! pronephric nephron development
relationship: results_in_development_of UBERON:0005310 ! pronephric nephron tubule
created_by: bf
creation_date: 2010-07-02T10:11:36Z

[Term]
id: GO:0039022
name: pronephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]
is_a: GO:0072176 ! nephric duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003060 ! pronephric duct
relationship: part_of GO:0048793 ! pronephros development
relationship: results_in_development_of UBERON:0003060 ! pronephric duct
created_by: bf
creation_date: 2010-07-02T10:15:03Z

[Term]
id: GO:0039023
name: pronephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150]
is_a: GO:0072178 ! nephric duct morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003060 ! pronephric duct
relationship: part_of GO:0039022 ! pronephric duct development
relationship: part_of GO:0072114 ! pronephros morphogenesis
relationship: results_in_morphogenesis_of UBERON:0003060 ! pronephric duct
created_by: bf
creation_date: 2010-07-02T10:18:09Z

[Term]
id: GO:0040003
name: chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "chitin-based cuticle anabolism" EXACT []
synonym: "chitin-based cuticle biosynthetic process" EXACT []
synonym: "chitin-based cuticle formation" EXACT []
synonym: "chitin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001001 ! chitin-based cuticle
relationship: in_taxon NCBITaxon:6656 {all_only="true"} ! Arthropoda
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: results_in_development_of UBERON:0001001 ! chitin-based cuticle

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_pir
subset: goslim_plant
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
is_a: GO:0008150 ! biological process
relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms

[Term]
id: GO:0040008
name: regulation of growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040007 ! growth
relationship: regulates GO:0040007 ! growth

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological process
property_value: RO:0002161 NCBITaxon:451864

[Term]
id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0040011 ! locomotion
relationship: regulates GO:0040011 ! locomotion

[Term]
id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "down regulation of locomotion" EXACT []
synonym: "down-regulation of locomotion" EXACT []
synonym: "downregulation of locomotion" EXACT []
synonym: "inhibition of locomotion" NARROW []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040011 ! locomotion
relationship: negatively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035264 ! multicellular organism growth
relationship: regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035264 ! multicellular organism growth
relationship: negatively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040016
name: embryonic cleavage
namespace: biological_process
def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "activation of locomotion" NARROW []
synonym: "stimulation of locomotion" NARROW []
synonym: "up regulation of locomotion" EXACT []
synonym: "up-regulation of locomotion" EXACT []
synonym: "upregulation of locomotion" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040011 ! locomotion
relationship: positively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035264 ! multicellular organism growth
relationship: positively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "activation of embryonic development" NARROW []
synonym: "stimulation of embryonic development" NARROW []
synonym: "up regulation of embryonic development" EXACT []
synonym: "up-regulation of embryonic development" EXACT []
synonym: "upregulation of embryonic development" EXACT []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009790 ! embryo development
relationship: positively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0040020
name: regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
synonym: "regulation of meiosis" BROAD [GOC:vw]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0140013 ! meiotic nuclear division
relationship: regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]
synonym: "developmental timing" RELATED []
synonym: "heterochronic regulation of development" EXACT []
synonym: "temporal regulation of development" EXACT []
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0042063
name: gliogenesis
namespace: biological_process
def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]
synonym: "glial cell generation" EXACT systematic_synonym []
is_a: GO:0022008 ! neurogenesis
intersection_of: GO:0008150 ! biological process
intersection_of: results_in_formation_of_anatomical_entity CL:0000125 ! glial cell
relationship: results_in_formation_of_anatomical_entity CL:0000125 ! glial cell

[Term]
id: GO:0042065
name: glial cell growth
namespace: biological_process
def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of CL:0000125 ! glial cell
relationship: part_of GO:0042063 ! gliogenesis
relationship: results_in_growth_of CL:0000125 ! glial cell

[Term]
id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]
synonym: "regulation of catecholamine metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006584 ! catecholamine metabolic process
relationship: regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042073
name: intraciliary transport
namespace: biological_process
alt_id: GO:0035734
def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "IFT" RELATED []
synonym: "intraflagellar transport" EXACT []
synonym: "intraflagellar transport involved in cilium organization" EXACT []
synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT []
xref: Wikipedia:Intraflagellar_transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0031503 ! protein-containing complex localization
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input GO:0032991 ! protein-containing complex
intersection_of: occurs_in GO:0005929 ! cilium
intersection_of: results_in_transport_along GO:0005874 ! microtubule
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: occurs_in GO:0005929 ! cilium
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0044782 ! cilium organization
property_value: RO:0002161 NCBITaxon:3176
property_value: RO:0002161 NCBITaxon:3312
property_value: RO:0002161 NCBITaxon:3378
property_value: RO:0002161 NCBITaxon:3398
property_value: RO:0002161 NCBITaxon:4890
property_value: RO:0002161 NCBITaxon:5782

[Term]
id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
alt_id: GO:0048131
def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]
synonym: "germ-line stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000014 ! germ line stem cell
relationship: has_primary_input CL:0000014 ! germ line stem cell
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0042098
name: T cell proliferation
namespace: biological_process
alt_id: GO:0042111
def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl]
synonym: "T lymphocyte proliferation" EXACT []
synonym: "T-cell proliferation" EXACT []
synonym: "T-lymphocyte proliferation" EXACT []
is_a: GO:0042110 ! T cell activation
is_a: GO:0046651 ! lymphocyte proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000084 ! T cell
relationship: acts_on_population_of CL:0000084 ! T cell

[Term]
id: GO:0042102
name: positive regulation of T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai]
synonym: "activation of T cell proliferation" NARROW []
synonym: "positive regulation of T lymphocyte proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte proliferation" EXACT []
synonym: "stimulation of T cell proliferation" NARROW []
synonym: "up regulation of T cell proliferation" EXACT []
synonym: "up-regulation of T cell proliferation" EXACT []
synonym: "upregulation of T cell proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042098 ! T cell proliferation
relationship: positively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]
synonym: "activation of T cell homeostatic proliferation" NARROW []
synonym: "positive regulation of resting T cell proliferation" EXACT []
synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "positive regulation of T-cell homeostatic proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT []
synonym: "stimulation of T cell homeostatic proliferation" NARROW []
synonym: "up regulation of T cell homeostatic proliferation" EXACT []
synonym: "up-regulation of T cell homeostatic proliferation" EXACT []
synonym: "upregulation of T cell homeostatic proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001777 ! T cell homeostatic proliferation
relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0042110
name: T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149]
synonym: "T lymphocyte activation" EXACT []
synonym: "T-cell activation" EXACT []
synonym: "T-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000084 ! T cell
relationship: has_primary_input CL:0000084 ! T cell

[Term]
id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000115 ! endothelial cell
relationship: has_primary_input CL:0000115 ! endothelial cell

[Term]
id: GO:0042127
name: regulation of cell population proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
synonym: "regulation of cell proliferation" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008283 ! cell population proliferation
relationship: regulates GO:0008283 ! cell population proliferation
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0042129
name: regulation of T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl]
synonym: "regulation of T lymphocyte proliferation" EXACT []
synonym: "regulation of T-cell proliferation" EXACT []
synonym: "regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042098 ! T cell proliferation
relationship: regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl]
synonym: "down regulation of T cell proliferation" EXACT []
synonym: "down-regulation of T cell proliferation" EXACT []
synonym: "downregulation of T cell proliferation" EXACT []
synonym: "inhibition of T cell proliferation" NARROW []
synonym: "negative regulation of T lymphocyte proliferation" EXACT []
synonym: "negative regulation of T-cell proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042098 ! T cell proliferation
relationship: negatively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042175
name: nuclear outer membrane-endoplasmic reticulum membrane network
namespace: cellular_component
def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]
synonym: "NE-ER continuum" RELATED []
synonym: "NE-ER network" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED []
synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah]
synonym: "nuclear envelope-ER network" RELATED []
synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah]
synonym: "nuclear membrane-ER network" EXACT [GOC:mah]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903362
alt_id: GO:2000598
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein catabolic process" EXACT []
synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "regulation of cyclin catabolic process" NARROW []
synonym: "regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "regulation of protein breakdown" EXACT []
synonym: "regulation of protein catabolism" EXACT []
synonym: "regulation of protein degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030163 ! protein catabolic process
relationship: regulates GO:0030163 ! protein catabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI
created_by: kmv
creation_date: 2014-08-21T15:05:45Z

[Term]
id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903363
alt_id: GO:2000599
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]
synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of protein catabolic process" EXACT []
synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process" EXACT []
synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein catabolic process" EXACT []
synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of protein catabolic process" NARROW []
synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein catabolic process" EXACT []
synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein breakdown" EXACT []
synonym: "negative regulation of protein catabolism" EXACT []
synonym: "negative regulation of protein degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030163 ! protein catabolic process
relationship: negatively_regulates GO:0030163 ! protein catabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0042180
name: cellular ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
synonym: "ketone metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:17087 ! ketone
relationship: has_primary_input_or_output CHEBI:17087 ! ketone

[Term]
id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
synonym: "ketone anabolism" EXACT []
synonym: "ketone biosynthesis" EXACT []
synonym: "ketone formation" EXACT []
synonym: "ketone synthesis" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:17087 ! ketone
relationship: has_primary_output CHEBI:17087 ! ketone

[Term]
id: GO:0042182
name: ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
synonym: "ketone breakdown" EXACT []
synonym: "ketone catabolism" EXACT []
synonym: "ketone degradation" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:17087 ! ketone
relationship: has_primary_input CHEBI:17087 ! ketone

[Term]
id: GO:0042221
name: response to chemical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_candida
subset: goslim_drosophila
subset: goslim_metagenomics
subset: goslim_plant
subset: goslim_yeast
synonym: "response to chemical stimulus" EXACT [GOC:dos]
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:24431 ! chemical entity
relationship: has_primary_input CHEBI:24431 ! chemical entity

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]
subset: goslim_candida
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "ribosome biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0042255
name: ribosome assembly
namespace: biological_process
alt_id: GO:0042257
def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]
subset: goslim_yeast
synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw]
is_a: GO:0140694 ! non-membrane-bounded organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005840 ! ribosome
relationship: part_of GO:0042254 ! ribosome biogenesis
relationship: results_in_assembly_of GO:0005840 ! ribosome

[Term]
id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016310 ! phosphorylation
relationship: regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]
synonym: "down regulation of phosphorylation" EXACT []
synonym: "down-regulation of phosphorylation" EXACT []
synonym: "downregulation of phosphorylation" EXACT []
synonym: "inhibition of phosphorylation" NARROW []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016310 ! phosphorylation
relationship: negatively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
synonym: "activation of phosphorylation" NARROW []
synonym: "stimulation of phosphorylation" NARROW []
synonym: "up regulation of phosphorylation" EXACT []
synonym: "up-regulation of phosphorylation" EXACT []
synonym: "upregulation of phosphorylation" EXACT []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016310 ! phosphorylation
relationship: positively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042335
name: cuticle development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]
subset: goslim_drosophila
synonym: "cuticle anabolism" EXACT []
synonym: "cuticle biosynthesis" EXACT []
synonym: "cuticle biosynthetic process" EXACT []
synonym: "cuticle formation" EXACT []
synonym: "cuticle synthesis" EXACT []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001002 ! cuticle
relationship: part_of GO:0007275 ! multicellular organism development
relationship: results_in_development_of UBERON:0001002 ! cuticle

[Term]
id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
is_a: BFO:0000003 ! occurrent
relationship: has_part GO:0034220 ! monoatomic ion transmembrane transport

[Term]
id: GO:0042401
name: biogenic amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
synonym: "biogenic amine anabolism" EXACT []
synonym: "biogenic amine biosynthesis" EXACT []
synonym: "biogenic amine formation" EXACT []
synonym: "biogenic amine synthesis" EXACT []
synonym: "cellular biogenic amine biosynthetic process" EXACT []
is_a: GO:0006576 ! biogenic amine metabolic process
is_a: GO:0009309 ! amine biosynthetic process

[Term]
id: GO:0042402
name: cellular biogenic amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732]
synonym: "biogenic amine breakdown" EXACT []
synonym: "biogenic amine catabolism" EXACT []
synonym: "biogenic amine degradation" EXACT []
is_a: GO:0009310 ! amine catabolic process

[Term]
id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol metabolic process" EXACT []
synonym: "levarterenol metabolism" EXACT []
synonym: "noradrenaline metabolic process" EXACT []
synonym: "noradrenaline metabolism" EXACT []
synonym: "norepinephrine metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: has_primary_input_or_output CHEBI:72587 ! (R)-noradrenaline(1+)

[Term]
id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol biosynthesis" EXACT []
synonym: "levarterenol biosynthetic process" EXACT []
synonym: "noradrenaline biosynthesis" EXACT []
synonym: "noradrenaline biosynthetic process" EXACT []
synonym: "norepinephrine anabolism" EXACT []
synonym: "norepinephrine biosynthesis" EXACT []
synonym: "norepinephrine formation" EXACT []
synonym: "norepinephrine synthesis" EXACT []
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: has_primary_output CHEBI:72587 ! (R)-noradrenaline(1+)

[Term]
id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]
synonym: "levarterenol catabolic process" EXACT []
synonym: "levarterenol catabolism" EXACT []
synonym: "noradrenaline catabolic process" EXACT []
synonym: "noradrenaline catabolism" EXACT []
synonym: "norepinephrine breakdown" EXACT []
synonym: "norepinephrine catabolism" EXACT []
synonym: "norepinephrine degradation" EXACT []
xref: Wikipedia:Norepinephrine#Degradation
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)

[Term]
id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine anabolism" EXACT []
synonym: "catecholamine biosynthesis" EXACT []
synonym: "catecholamine formation" EXACT []
synonym: "catecholamine synthesis" EXACT []
xref: Wikipedia:Catecholamines
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0009713 ! catechol-containing compound biosynthetic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33567 ! catecholamine
relationship: has_primary_output CHEBI:33567 ! catecholamine

[Term]
id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]
synonym: "catecholamine breakdown" EXACT []
synonym: "catecholamine catabolism" EXACT []
synonym: "catecholamine degradation" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0019614 ! catechol-containing compound catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33567 ! catecholamine
relationship: has_primary_input CHEBI:33567 ! catecholamine

[Term]
id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin anabolism" EXACT []
synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042428 ! serotonin metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:350546 ! serotonin(1+)
relationship: has_primary_output CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0097164 ! ammonium ion metabolic process
is_a: GO:1901160 ! primary amino compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:350546 ! serotonin(1+)
relationship: has_primary_input_or_output CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]
synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042428 ! serotonin metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+)
relationship: has_primary_input CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0042430
name: indole-containing compound metabolic process
namespace: biological_process
alt_id: GO:0042434
def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah]
synonym: "indole and derivative metabolic process" EXACT []
synonym: "indole and derivative metabolism" EXACT []
synonym: "indole derivative metabolic process" NARROW []
synonym: "indole derivative metabolism" NARROW []
synonym: "indole-containing compound metabolism" EXACT []
synonym: "ketole metabolic process" EXACT []
synonym: "ketole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:24828 ! indoles
relationship: has_primary_input_or_output CHEBI:24828 ! indoles

[Term]
id: GO:0042435
name: indole-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative biosynthesis" EXACT []
synonym: "indole derivative biosynthetic process" EXACT []
synonym: "indole-containing compound anabolism" EXACT []
synonym: "indole-containing compound biosynthesis" EXACT []
synonym: "indole-containing compound formation" EXACT []
synonym: "indole-containing compound synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:24828 ! indoles
relationship: has_primary_output CHEBI:24828 ! indoles

[Term]
id: GO:0042436
name: indole-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]
synonym: "indole derivative catabolic process" EXACT []
synonym: "indole derivative catabolism" EXACT []
synonym: "indole-containing compound breakdown" EXACT []
synonym: "indole-containing compound catabolism" EXACT []
synonym: "indole-containing compound degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042430 ! indole-containing compound metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:24828 ! indoles
relationship: has_primary_input CHEBI:24828 ! indoles

[Term]
id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
alt_id: GO:0046531
def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
synonym: "photoreceptor morphogenesis" EXACT []
is_a: GO:0048666 ! neuron development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000210 ! photoreceptor cell
relationship: part_of GO:0046530 ! photoreceptor cell differentiation
relationship: results_in_development_of CL:0000210 ! photoreceptor cell

[Term]
id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
is_a: GO:0042461 ! photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000287 ! eye photoreceptor cell
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation
relationship: results_in_development_of CL:0000287 ! eye photoreceptor cell

[Term]
id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "regulation of eye photoreceptor development" EXACT []
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042462 ! eye photoreceptor cell development
relationship: regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "activation of eye photoreceptor cell development" NARROW []
synonym: "positive regulation of eye photoreceptor development" EXACT []
synonym: "stimulation of eye photoreceptor cell development" NARROW []
synonym: "up regulation of eye photoreceptor cell development" EXACT []
synonym: "up-regulation of eye photoreceptor cell development" EXACT []
synonym: "upregulation of eye photoreceptor cell development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042462 ! eye photoreceptor cell development
relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "down regulation of eye photoreceptor cell development" EXACT []
synonym: "down-regulation of eye photoreceptor cell development" EXACT []
synonym: "downregulation of eye photoreceptor cell development" EXACT []
synonym: "inhibition of eye photoreceptor cell development" NARROW []
synonym: "negative regulation of eye photoreceptor development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042462 ! eye photoreceptor cell development
relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042551
name: neuron maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000540 ! neuron
relationship: part_of GO:0048666 ! neuron development
relationship: results_in_maturation_of CL:0000540 ! neuron

[Term]
id: GO:0042588
name: zymogen granule
namespace: cellular_component
def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0042588 ! zymogen granule
relationship: bounding_layer_of GO:0042588 ! zymogen granule
relationship: part_of GO:0042588 ! zymogen granule

[Term]
id: GO:0042592
name: homeostatic process
namespace: biological_process
alt_id: GO:0032844
alt_id: GO:0032845
alt_id: GO:0032846
def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_mouse
synonym: "activation of homeostatic process" NARROW []
synonym: "homeostasis" EXACT []
synonym: "inhibition of homeostatic process" NARROW []
synonym: "negative regulation of homeostatic process" RELATED []
synonym: "positive regulation of homeostatic process" RELATED []
synonym: "regulation of homeostatic process" RELATED []
is_a: GO:0008150 ! biological process

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0098797 ! plasma membrane protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
synonym: "actomyosin complex" EXACT []
synonym: "actomyosin structure" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000573 ! retinal cone cell
relationship: results_in_acquisition_of_features_of CL:0000573 ! retinal cone cell

[Term]
id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]
synonym: "myogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000187 ! muscle cell
relationship: part_of GO:0061061 ! muscle structure development
relationship: results_in_acquisition_of_features_of CL:0000187 ! muscle cell

[Term]
id: GO:0042698
name: ovulation cycle
namespace: biological_process
def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544]
is_a: GO:0048511 ! rhythmic process
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota

[Term]
id: GO:0042702
name: uterine wall growth
namespace: biological_process
def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0040007 ! growth
intersection_of: results_in_growth_of UBERON:0000459 ! uterine wall
relationship: part_of GO:0001553 ! luteinization
relationship: results_in_growth_of UBERON:0000459 ! uterine wall

[Term]
id: GO:0042713
name: sperm ejaculation
namespace: biological_process
def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042742
name: defense response to bacterium
namespace: biological_process
alt_id: GO:0009816
alt_id: GO:0042830
def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
synonym: "antibacterial peptide activity" RELATED []
synonym: "defence response to bacteria" EXACT []
synonym: "defence response to bacterium" EXACT []
synonym: "defense response to bacteria" EXACT []
synonym: "defense response to bacterium, incompatible interaction" NARROW []
synonym: "resistance response to pathogenic bacteria" NARROW []
synonym: "resistance response to pathogenic bacterium" NARROW []
is_a: GO:0009617 ! response to bacterium
is_a: GO:0098542 ! defense response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: has_primary_input NCBITaxon:2 ! Bacteria

[Term]
id: GO:0042762
name: regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators]
synonym: "regulation of sulfur metabolism" EXACT []
synonym: "regulation of sulphur metabolic process" EXACT []
synonym: "regulation of sulphur metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006790 ! sulfur compound metabolic process
relationship: regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:32988 ! amide
relationship: has_primary_input CHEBI:32988 ! amide

[Term]
id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:32988 ! amide
relationship: has_primary_input CHEBI:32988 ! amide
relationship: part_of GO:0042886 ! amide transport

[Term]
id: GO:0042981
name: regulation of apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "apoptosis regulator activity" RELATED []
synonym: "regulation of apoptosis" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006915 ! apoptotic process
relationship: regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell

[Term]
id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT []
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport
relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]
is_a: GO:0006893 ! Golgi to plasma membrane transport
is_a: GO:0015031 ! protein transport
is_a: GO:0061951 ! establishment of protein localization to plasma membrane
is_a: GO:0072659 ! protein localization to plasma membrane
intersection_of: GO:0015031 ! protein transport
intersection_of: has_target_end_location GO:0005886 ! plasma membrane
intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus
intersection_of: process_has_causal_agent GO:0031982 ! vesicle

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
synonym: "nerve fiber" RELATED [GOC:dph]
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889]
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao867568886
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: part_of CL:0000540 ! neuron
relationship: part_of CL:0000540 ! neuron
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching
relationship: in_taxon NCBITaxon:7711 {all_only="true"} ! Chordata
relationship: only_in_taxon NCBITaxon:7711 ! Chordata

[Term]
id: GO:0043010
name: camera-type eye development
namespace: biological_process
alt_id: GO:0001747
alt_id: GO:0031075
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000019 ! camera-type eye
relationship: results_in_development_of UBERON:0000019 ! camera-type eye
property_value: RO:0002161 NCBITaxon:6656

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body
intersection_of: GO:0044297 ! cell body
intersection_of: part_of CL:0000540 ! neuron
relationship: part_of GO:0036477 ! somatodendritic compartment

[Term]
id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149]
comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "T lymphocyte homeostasis" EXACT []
synonym: "T-cell homeostasis" EXACT []
synonym: "T-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000084 ! T cell
relationship: acts_on_population_of CL:0000084 ! T cell

[Term]
id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]
synonym: "peptide anabolism" EXACT []
synonym: "peptide biosynthesis" EXACT []
synonym: "peptide formation" EXACT []
synonym: "peptide synthesis" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:16670 ! peptide
relationship: has_primary_output CHEBI:16670 ! peptide

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: goslim_prokaryote
synonym: "extracellular structure organisation" EXACT []
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005576 ! extracellular region
relationship: results_in_organization_of GO:0005576 ! extracellular region

[Term]
id: GO:0043065
name: positive regulation of apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
subset: goslim_chembl
synonym: "activation of apoptosis" NARROW []
synonym: "positive regulation of apoptosis" NARROW []
synonym: "pro-apoptosis" RELATED []
synonym: "stimulation of apoptosis" NARROW []
synonym: "up regulation of apoptosis" EXACT []
synonym: "up-regulation of apoptosis" EXACT []
synonym: "upregulation of apoptosis" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043068 ! positive regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006915 ! apoptotic process
relationship: positively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043066
name: negative regulation of apoptotic process
namespace: biological_process
alt_id: GO:0006916
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]
comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used.
synonym: "anti-apoptosis" EXACT []
synonym: "apoptosis inhibitor activity" RELATED []
synonym: "down regulation of apoptosis" EXACT []
synonym: "down-regulation of apoptosis" EXACT []
synonym: "downregulation of apoptosis" EXACT []
synonym: "inhibition of apoptosis" NARROW []
synonym: "negative regulation of apoptosis" NARROW []
synonym: "pro-survival" RELATED []
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0043069 ! negative regulation of programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006915 ! apoptotic process
relationship: negatively_regulates GO:0006915 ! apoptotic process

[Term]
id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043070
def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0012501 ! programmed cell death
relationship: regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043071
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "activation of programmed cell death" NARROW []
synonym: "positive regulation of non-apoptotic programmed cell death" NARROW []
synonym: "stimulation of programmed cell death" NARROW []
synonym: "up regulation of programmed cell death" EXACT []
synonym: "up-regulation of programmed cell death" EXACT []
synonym: "upregulation of programmed cell death" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0012501 ! programmed cell death
relationship: positively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043072
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "down regulation of programmed cell death" EXACT []
synonym: "down-regulation of programmed cell death" EXACT []
synonym: "downregulation of programmed cell death" EXACT []
synonym: "inhibition of programmed cell death" NARROW []
synonym: "negative regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0012501 ! programmed cell death
relationship: negatively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators]
synonym: "germ-cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus
intersection_of: GO:0005634 ! nucleus
intersection_of: part_of CL:0000586 ! germ cell
relationship: part_of CL:0000586 ! germ cell

[Term]
id: GO:0043085
name: positive regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048554
def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_chembl
synonym: "activation of enzyme activity" NARROW []
synonym: "activation of metalloenzyme activity" NARROW []
synonym: "positive regulation of enzyme activity" EXACT [GOC:tb]
synonym: "positive regulation of metalloenzyme activity" NARROW []
synonym: "stimulation of enzyme activity" NARROW []
synonym: "stimulation of metalloenzyme activity" NARROW []
synonym: "up regulation of enzyme activity" EXACT []
synonym: "up regulation of metalloenzyme activity" NARROW []
synonym: "up-regulation of enzyme activity" EXACT []
synonym: "up-regulation of metalloenzyme activity" NARROW []
synonym: "upregulation of enzyme activity" EXACT []
synonym: "upregulation of metalloenzyme activity" NARROW []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003824 ! catalytic activity
relationship: positively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0043086
name: negative regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048553
def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
subset: gocheck_do_not_annotate
synonym: "down regulation of enzyme activity" EXACT []
synonym: "down regulation of metalloenzyme activity" NARROW []
synonym: "down-regulation of enzyme activity" EXACT []
synonym: "down-regulation of metalloenzyme activity" EXACT []
synonym: "downregulation of enzyme activity" EXACT []
synonym: "downregulation of metalloenzyme activity" NARROW []
synonym: "inhibition of enzyme activity" NARROW []
synonym: "inhibition of metalloenzyme activity" NARROW []
synonym: "negative regulation of enzyme activity" EXACT [GOC:tb]
synonym: "negative regulation of metalloenzyme activity" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003824 ! catalytic activity
relationship: negatively_regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0043133
name: hindgut contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0022600 ! digestive system process
intersection_of: GO:0006939 ! smooth muscle contraction
intersection_of: occurs_in UBERON:0001046 ! hindgut
relationship: occurs_in UBERON:0001046 ! hindgut

[Term]
id: GO:0043134
name: regulation of hindgut contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044058 ! regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043133 ! hindgut contraction
relationship: regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0043143
name: regulation of translation by machinery localization
namespace: biological_process
def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
synonym: "establishment and maintenance of translational machinery localization" EXACT []
synonym: "establishment and maintenance of translational protein localization" EXACT []
synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah]
synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb]
synonym: "translational protein localization" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: part_of GO:0006412 ! translation
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
alt_id: GO:0043283
alt_id: GO:0044259
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
synonym: "multicellular organismal macromolecule metabolic process" NARROW []
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33694 ! biomacromolecule
relationship: has_primary_input_or_output CHEBI:33694 ! biomacromolecule
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]
synonym: "peptide breakdown" EXACT []
synonym: "peptide catabolism" EXACT []
synonym: "peptide degradation" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:16670 ! peptide
relationship: has_primary_input CHEBI:16670 ! peptide

[Term]
id: GO:0043200
name: response to amino acid
namespace: biological_process
alt_id: GO:0010237
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg]
synonym: "response to amino acid stimulus" EXACT [GOC:dos]
is_a: GO:0001101 ! response to acid chemical
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:33709 ! amino acid
relationship: has_primary_input CHEBI:33709 ! amino acid

[Term]
id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_prokaryote
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0110165 ! cellular anatomical entity

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: has_part GO:0016020 ! membrane
disjoint_from: GO:0043228 ! non-membrane-bounded organelle
relationship: has_part GO:0016020 ! membrane

[Term]
id: GO:0043228
name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_mouse
synonym: "biological condensate" RELATED []
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21881" xsd:anyURI

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: part_of GO:0005622 ! intracellular anatomical structure
disjoint_from: GO:0043230 ! extracellular organelle
relationship: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
is_a: GO:0043226 ! organelle
intersection_of: GO:0043226 ! organelle
intersection_of: part_of GO:0005576 ! extracellular region
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle
intersection_of: GO:0043227 ! membrane-bounded organelle
intersection_of: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0043232
name: intracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_pir
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle
intersection_of: GO:0043228 ! non-membrane-bounded organelle
intersection_of: part_of GO:0005622 ! intracellular anatomical structure

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]
subset: goslim_mouse
is_a: GO:0031974 ! membrane-enclosed lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0043226 ! organelle
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0043242
name: negative regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "down regulation of protein complex disassembly" EXACT []
synonym: "down-regulation of protein complex disassembly" EXACT []
synonym: "downregulation of protein complex disassembly" EXACT []
synonym: "inhibition of protein complex disassembly" NARROW []
synonym: "negative regulation of protein complex disassembly" RELATED []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032984 ! protein-containing complex disassembly
relationship: negatively_regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043243
name: positive regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "activation of protein complex disassembly" NARROW []
synonym: "positive regulation of protein complex disassembly" RELATED []
synonym: "stimulation of protein complex disassembly" NARROW []
synonym: "up regulation of protein complex disassembly" EXACT []
synonym: "up-regulation of protein complex disassembly" EXACT []
synonym: "upregulation of protein complex disassembly" EXACT []
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032984 ! protein-containing complex disassembly
relationship: positively_regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043244
name: regulation of protein-containing complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "regulation of protein complex disassembly" RELATED []
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032984 ! protein-containing complex disassembly
relationship: regulates GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]
synonym: "RBC maturation" EXACT [CL:0000232]
synonym: "red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000232 ! erythrocyte
relationship: part_of GO:0048821 ! erythrocyte development
relationship: results_in_maturation_of CL:0000232 ! erythrocyte

[Term]
id: GO:0043254
name: regulation of protein-containing complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]
synonym: "regulation of protein complex assembly" RELATED []
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0065003 ! protein-containing complex assembly
relationship: regulates GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]
synonym: "regulation of carbohydrate anabolism" EXACT []
synonym: "regulation of carbohydrate biosynthesis" EXACT []
synonym: "regulation of carbohydrate formation" EXACT []
synonym: "regulation of carbohydrate synthesis" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016051 ! carbohydrate biosynthetic process
relationship: regulates GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0043264
name: extracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
synonym: "extracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle
intersection_of: GO:0043228 ! non-membrane-bounded organelle
intersection_of: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0043269
name: regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of ion transport" BROAD []
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006811 ! monoatomic ion transport
relationship: regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043270
name: positive regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "activation of ion transport" NARROW []
synonym: "stimulation of ion transport" NARROW []
synonym: "up regulation of ion transport" EXACT []
synonym: "up-regulation of ion transport" EXACT []
synonym: "upregulation of ion transport" EXACT []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006811 ! monoatomic ion transport
relationship: positively_regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043271
name: negative regulation of monoatomic ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of ion transport" EXACT []
synonym: "down-regulation of ion transport" EXACT []
synonym: "downregulation of ion transport" EXACT []
synonym: "inhibition of ion transport" NARROW []
synonym: "negative regulation of ion transport" BROAD []
is_a: GO:0043269 ! regulation of monoatomic ion transport
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006811 ! monoatomic ion transport
relationship: negatively_regulates GO:0006811 ! monoatomic ion transport

[Term]
id: GO:0043279
name: response to alkaloid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl]
is_a: GO:0010243 ! response to organonitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:22315 ! alkaloid
relationship: has_primary_input CHEBI:22315 ! alkaloid

[Term]
id: GO:0043292
name: contractile fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
synonym: "contractile fibre" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0099512 ! supramolecular fiber
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: part_of CL:0000187 ! muscle cell
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0043353
name: enucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "enucleate RBC differentiation" EXACT [CL:0000232]
synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000595 ! enucleate erythrocyte
relationship: results_in_acquisition_of_features_of CL:0000595 ! enucleate erythrocyte

[Term]
id: GO:0043354
name: enucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators]
synonym: "enucleate RBC maturation" EXACT [CL:0000232]
synonym: "enucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000595 ! enucleate erythrocyte
relationship: part_of GO:0048822 ! enucleate erythrocyte development
relationship: results_in_maturation_of CL:0000595 ! enucleate erythrocyte

[Term]
id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]
synonym: "nucleate RBC maturation" EXACT [CL:0000232]
synonym: "nucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000562 ! nucleate erythrocyte
relationship: part_of GO:0048823 ! nucleate erythrocyte development
relationship: results_in_maturation_of CL:0000562 ! nucleate erythrocyte

[Term]
id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]
synonym: "nucleate RBC differentiation" EXACT [CL:0000232]
synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000562 ! nucleate erythrocyte
relationship: results_in_acquisition_of_features_of CL:0000562 ! nucleate erythrocyte

[Term]
id: GO:0043434
name: response to peptide hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
synonym: "response to peptide hormone stimulus" EXACT [GOC:dos]
synonym: "response to polypeptide hormone stimulus" EXACT []
is_a: GO:0009725 ! response to hormone
is_a: GO:1901652 ! response to peptide
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:25905 ! peptide hormone
relationship: has_primary_input CHEBI:25905 ! peptide hormone

[Term]
id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]
synonym: "keto acid metabolic process" EXACT []
synonym: "keto acid metabolism" EXACT []
synonym: "ketoacid metabolic process" EXACT []
synonym: "ketoacid metabolism" EXACT []
synonym: "oxo acid metabolic process" EXACT []
synonym: "oxo acid metabolism" EXACT []
synonym: "oxoacid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35406 ! oxoanion
relationship: has_primary_input_or_output CHEBI:35406 ! oxoanion

[Term]
id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
synonym: "regulation of secondary metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019748 ! secondary metabolic process
relationship: regulates GO:0019748 ! secondary metabolic process

[Term]
id: GO:0043467
name: regulation of generation of precursor metabolites and energy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006091 ! generation of precursor metabolites and energy
relationship: regulates GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016052 ! carbohydrate catabolic process
relationship: regulates GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]
subset: goslim_chembl
subset: goslim_pir
is_a: GO:0008150 ! biological process
relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0003012 ! muscle system process
is_a: GO:0050896 ! response to stimulus
relationship: occurs_in UBERON:0002385 ! muscle tissue

[Term]
id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation
intersection_of: GO:0043500 ! muscle adaptation
intersection_of: occurs_in UBERON:0001134 ! skeletal muscle tissue
relationship: occurs_in UBERON:0001134 ! skeletal muscle tissue

[Term]
id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]
synonym: "regulation of muscle plasticity" RELATED []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0090257 ! regulation of muscle system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043500 ! muscle adaptation
relationship: regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0043523
name: regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of neuronal cells" EXACT []
synonym: "regulation of apoptosis of neurons" EXACT []
synonym: "regulation of neuron apoptosis" NARROW []
synonym: "regulation of neuron programmed cell death" EXACT []
synonym: "regulation of neuronal cell programmed cell death" EXACT []
synonym: "regulation of programmed cell death of neuronal cells" EXACT []
synonym: "regulation of programmed cell death, neurons" EXACT []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051402 ! neuron apoptotic process
relationship: regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043524
name: negative regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "down regulation of neuron apoptosis" EXACT []
synonym: "down-regulation of neuron apoptosis" EXACT []
synonym: "downregulation of neuron apoptosis" EXACT []
synonym: "inhibition of neuron apoptosis" NARROW []
synonym: "negative regulation of neuron apoptosis" NARROW []
synonym: "negative regulation of programmed cell death, neurons" EXACT []
synonym: "neuron survival" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process
relationship: negatively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043525
name: positive regulation of neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]
synonym: "activation of neuron apoptosis" NARROW []
synonym: "positive regulation of neuron apoptosis" NARROW []
synonym: "positive regulation of programmed cell death, neurons" EXACT []
synonym: "stimulation of neuron apoptosis" NARROW []
synonym: "up regulation of neuron apoptosis" EXACT []
synonym: "up-regulation of neuron apoptosis" EXACT []
synonym: "upregulation of neuron apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051402 ! neuron apoptotic process
relationship: positively_regulates GO:0051402 ! neuron apoptotic process

[Term]
id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]
is_a: GO:0043542 ! endothelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000071 ! blood vessel endothelial cell
relationship: results_in_movement_of CL:0000071 ! blood vessel endothelial cell

[Term]
id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
is_a: GO:0010594 ! regulation of endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "activation of blood vessel endothelial cell migration" NARROW []
synonym: "stimulation of blood vessel endothelial cell migration" NARROW []
synonym: "up regulation of blood vessel endothelial cell migration" EXACT []
synonym: "up-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "upregulation of blood vessel endothelial cell migration" EXACT []
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "down regulation of blood vessel endothelial cell migration" EXACT []
synonym: "down-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "downregulation of blood vessel endothelial cell migration" EXACT []
synonym: "inhibition of blood vessel endothelial cell migration" NARROW []
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration
relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]
is_a: GO:0010631 ! epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000115 ! endothelial cell
relationship: results_in_movement_of CL:0000115 ! endothelial cell

[Term]
id: GO:0043549
name: regulation of kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]
subset: gocheck_do_not_annotate
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016301 ! kinase activity
relationship: regulates GO:0016301 ! kinase activity

[Term]
id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system

[Term]
id: GO:0043588
name: skin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
synonym: "animal skin development" EXACT []
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002097 ! skin of body
relationship: results_in_development_of UBERON:0002097 ! skin of body
property_value: RO:0002161 NCBITaxon:50557
property_value: RO:0002161 NCBITaxon:6656

[Term]
id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002097 ! skin of body
relationship: part_of GO:0043588 ! skin development
relationship: results_in_morphogenesis_of UBERON:0002097 ! skin of body

[Term]
id: GO:0043603
name: amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]
subset: goslim_pir
synonym: "amide metabolism" EXACT []
synonym: "cellular amide metabolic process" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:32988 ! amide
relationship: has_primary_input_or_output CHEBI:32988 ! amide

[Term]
id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
is_a: GO:0043603 ! amide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:32988 ! amide
relationship: has_primary_output CHEBI:32988 ! amide

[Term]
id: GO:0043605
name: amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]
synonym: "cellular amide catabolic process" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043603 ! amide metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_output CHEBI:32988 ! amide
relationship: has_primary_output CHEBI:32988 ! amide

[Term]
id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]
synonym: "dicarboxylate metabolic process" EXACT []
synonym: "dicarboxylate metabolism" EXACT []
synonym: "dicarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35693 ! dicarboxylic acid anion
relationship: has_primary_input_or_output CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate catabolic process" EXACT []
synonym: "dicarboxylate catabolism" EXACT []
synonym: "dicarboxylic acid breakdown" EXACT []
synonym: "dicarboxylic acid catabolism" EXACT []
synonym: "dicarboxylic acid degradation" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:35693 ! dicarboxylic acid anion
relationship: has_primary_input CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "dicarboxylate biosynthesis" EXACT []
synonym: "dicarboxylate biosynthetic process" EXACT []
synonym: "dicarboxylic acid anabolism" EXACT []
synonym: "dicarboxylic acid biosynthesis" EXACT []
synonym: "dicarboxylic acid formation" EXACT []
synonym: "dicarboxylic acid synthesis" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:35693 ! dicarboxylic acid anion
relationship: has_primary_output CHEBI:35693 ! dicarboxylic acid anion

[Term]
id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]
synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034]
synonym: "ossification involved in skeletal development" EXACT [GOC:dph]
is_a: GO:0001503 ! ossification
intersection_of: GO:0001503 ! ossification
intersection_of: part_of GO:0070977 ! bone maturation
relationship: part_of GO:0070977 ! bone maturation

[Term]
id: GO:0043933
name: protein-containing complex organization
namespace: biological_process
alt_id: GO:0034600
alt_id: GO:0034621
alt_id: GO:0071822
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]
synonym: "cellular macromolecular complex organization" RELATED []
synonym: "cellular macromolecular complex subunit organisation" RELATED []
synonym: "cellular macromolecular complex subunit organization" RELATED []
synonym: "macromolecular complex organization" RELATED []
synonym: "macromolecular complex subunit organisation" RELATED []
synonym: "macromolecular complex subunit organization" RELATED []
synonym: "protein complex subunit organisation" EXACT [GOC:mah]
synonym: "protein complex subunit organization" EXACT []
synonym: "protein-containing complex subunit organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0032991 ! protein-containing complex
relationship: results_in_organization_of GO:0032991 ! protein-containing complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI
created_by: mah
creation_date: 2010-09-08T10:01:42Z

[Term]
id: GO:0044042
name: glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]
synonym: "glucan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:37163 ! glucan
relationship: has_primary_input_or_output CHEBI:37163 ! glucan

[Term]
id: GO:0044057
name: regulation of system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003008 ! system process
relationship: regulates GO:0003008 ! system process

[Term]
id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022600 ! digestive system process
relationship: regulates GO:0022600 ! digestive system process

[Term]
id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
synonym: "regulation of endocrine system process" EXACT []
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050886 ! endocrine process
relationship: regulates GO:0050886 ! endocrine process

[Term]
id: GO:0044062
name: regulation of excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007588 ! excretion
relationship: regulates GO:0007588 ! excretion

[Term]
id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003016 ! respiratory system process
relationship: regulates GO:0003016 ! respiratory system process

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
alt_id: GO:0071843
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "cellular component biogenesis at cellular level" EXACT []
is_a: GO:0071840 ! cellular component organization or biogenesis

[Term]
id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044085 ! cellular component biogenesis
relationship: regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007033 ! vacuole organization
relationship: regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044085 ! cellular component biogenesis
relationship: positively_regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044088 ! regulation of vacuole organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007033 ! vacuole organization
relationship: positively_regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]
is_a: GO:0044085 ! cellular component biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: has_primary_output GO:0016020 ! membrane
relationship: has_primary_output GO:0016020 ! membrane

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003674 ! molecular_function
relationship: negatively_regulates GO:0003674 ! molecular_function
created_by: jl
creation_date: 2009-04-21T04:07:27Z

[Term]
id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
subset: gocheck_do_not_annotate
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003674 ! molecular_function
relationship: positively_regulates GO:0003674 ! molecular_function
created_by: jl
creation_date: 2009-04-21T04:11:06Z

[Term]
id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]
synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW []
synonym: "translation initiation (ternary) complex" EXACT []
is_a: GO:1990904 ! ribonucleoprotein complex
relationship: part_of GO:0005737 ! cytoplasm
created_by: jl
creation_date: 2009-10-22T02:38:55Z

[Term]
id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
comment: This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.
subset: gocheck_do_not_annotate
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_a: GO:0008152 ! metabolic process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "primary metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0044248
name: cellular catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]
synonym: "cellular breakdown" EXACT []
synonym: "cellular catabolism" EXACT []
synonym: "cellular degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044249
name: cellular biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]
synonym: "cellular anabolism" EXACT []
synonym: "cellular biosynthesis" EXACT []
synonym: "cellular formation" EXACT []
synonym: "cellular synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044258
name: intestinal lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "intestinal lipid breakdown" EXACT []
synonym: "intestinal lipid catabolism" EXACT []
synonym: "intestinal lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
intersection_of: GO:0016042 ! lipid catabolic process
intersection_of: occurs_in UBERON:0000160 ! intestine
relationship: occurs_in UBERON:0000160 ! intestine

[Term]
id: GO:0044270
name: cellular nitrogen compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
synonym: "nitrogen compound breakdown" BROAD []
synonym: "nitrogen compound catabolism" BROAD []
synonym: "nitrogen compound degradation" BROAD []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044271
name: cellular nitrogen compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]
synonym: "nitrogen compound anabolism" BROAD []
synonym: "nitrogen compound biosynthesis" BROAD []
synonym: "nitrogen compound formation" BROAD []
synonym: "nitrogen compound synthesis" BROAD []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044272
name: sulfur compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
synonym: "sulfur biosynthesis" NARROW []
synonym: "sulfur biosynthetic process" NARROW []
synonym: "sulfur compound anabolism" EXACT []
synonym: "sulfur compound biosynthesis" EXACT []
synonym: "sulfur compound formation" EXACT []
synonym: "sulfur compound synthesis" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:26835 ! sulfur molecular entity
relationship: has_primary_output CHEBI:26835 ! sulfur molecular entity

[Term]
id: GO:0044273
name: sulfur compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
synonym: "sulfur catabolic process" NARROW []
synonym: "sulfur catabolism" NARROW []
synonym: "sulfur compound breakdown" EXACT []
synonym: "sulfur compound catabolism" EXACT []
synonym: "sulfur compound degradation" EXACT []
is_a: GO:0006790 ! sulfur compound metabolic process
is_a: GO:0044248 ! cellular catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity
relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity

[Term]
id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "small molecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
created_by: jl
creation_date: 2010-01-26T12:05:20Z

[Term]
id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
synonym: "small molecule catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044281 ! small molecule metabolic process
created_by: jl
creation_date: 2010-01-26T12:06:10Z

[Term]
id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]
comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
subset: goslim_prokaryote
synonym: "small molecule biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044281 ! small molecule metabolic process
created_by: jl
creation_date: 2010-01-26T12:06:49Z

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
synonym: "cell soma" EXACT []
xref: FBbt:00005107
xref: FMA:67301
xref: Wikipedia:Cell_body
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell
property_value: RO:0002161 NCBITaxon:4890
created_by: jl
creation_date: 2010-02-05T10:37:16Z

[Term]
id: GO:0044342
name: type B pancreatic cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]
synonym: "pancreatic B cell proliferation" EXACT [GOC:mah]
synonym: "pancreatic beta cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000169 ! type B pancreatic cell
relationship: acts_on_population_of CL:0000169 ! type B pancreatic cell
created_by: jl
creation_date: 2010-08-25T01:44:51Z

[Term]
id: GO:0044346
name: fibroblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]
synonym: "fibroblast apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000057 ! fibroblast
relationship: occurs_in CL:0000057 ! fibroblast
created_by: jl
creation_date: 2010-09-23T11:33:38Z

[Term]
id: GO:0044380
name: protein localization to cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]
synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005856 ! cytoskeleton
relationship: has_target_end_location GO:0005856 ! cytoskeleton
created_by: jl
creation_date: 2011-12-13T11:43:24Z

[Term]
id: GO:0044419
name: biological process involved in interspecies interaction between organisms
namespace: biological_process
def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction between organisms" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0008150 ! biological process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20191" xsd:anyURI
property_value: RO:0002161 NCBITaxon:4895

[Term]
id: GO:0044458
name: motile cilium assembly
namespace: biological_process
alt_id: GO:1903887
def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]
synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "motile primary cilium assembly" RELATED []
synonym: "motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0060271 ! cilium assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0031514 ! motile cilium
relationship: results_in_assembly_of GO:0031514 ! motile cilium
created_by: krc
creation_date: 2015-02-06T17:23:23Z

[Term]
id: GO:0044550
name: secondary metabolite biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
subset: goslim_prokaryote
synonym: "secondary metabolite biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0019748 ! secondary metabolic process
created_by: jl
creation_date: 2012-03-29T01:55:18Z

[Term]
id: GO:0044565
name: dendritic cell proliferation
namespace: biological_process
def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816]
is_a: GO:0032943 ! mononuclear cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000451 ! dendritic cell
relationship: acts_on_population_of CL:0000451 ! dendritic cell
created_by: jl
creation_date: 2012-04-05T04:31:39Z

[Term]
id: GO:0044566
name: chondrocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000138 ! chondrocyte
relationship: has_primary_input CL:0000138 ! chondrocyte
created_by: jl
creation_date: 2012-04-05T04:45:38Z

[Term]
id: GO:0044703
name: multi-organism reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]
subset: goslim_drosophila
is_a: GO:0022414 ! reproductive process
created_by: jl
creation_date: 2012-09-19T15:56:30Z

[Term]
id: GO:0044706
name: multi-multicellular organism process
namespace: biological_process
def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]
is_a: GO:0032501 ! multicellular organismal process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21459" xsd:anyURI
created_by: jl
creation_date: 2012-09-19T16:06:16Z

[Term]
id: GO:0044782
name: cilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
subset: goslim_drosophila
subset: goslim_generic
synonym: "microtubule-based flagellum organization" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005929 ! cilium
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: results_in_organization_of GO:0005929 ! cilium
created_by: jl
creation_date: 2013-03-27T15:09:58Z

[Term]
id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
alt_id: GO:0006947
def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" BROAD []
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0061025 ! membrane fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0005886 ! plasma membrane
relationship: results_in_fusion_of GO:0005886 ! plasma membrane

[Term]
id: GO:0045120
name: pronucleus
namespace: cellular_component
def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732]
xref: Wikipedia:Pronucleus
is_a: GO:0005634 ! nucleus
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
is_a: GO:0098813 ! nuclear chromosome segregation
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0098813 ! nuclear chromosome segregation
intersection_of: part_of GO:0140013 ! meiotic nuclear division
relationship: part_of GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! developmental process involved in reproduction
relationship: part_of GO:0007275 ! multicellular organism development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
synonym: "meiosis II, chromosome segregation" EXACT []
is_a: GO:0000819 ! sister chromatid segregation
is_a: GO:0045132 ! meiotic chromosome segregation
is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle
intersection_of: GO:0000819 ! sister chromatid segregation
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0045165
name: cell fate commitment
namespace: biological_process
def: "The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]
comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI

[Term]
id: GO:0045168
name: cell-cell signaling involved in cell fate commitment
namespace: biological_process
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell fate commitment, cell-cell signaling" EXACT []
synonym: "cell fate commitment, cell-cell signalling" EXACT []
synonym: "cell-cell signaling during in cell fate commitment" EXACT []
synonym: "cell-cell signaling resulting in cell fate commitment" EXACT []
synonym: "cell-cell signalling during cell fate commitment" EXACT []
synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb]
synonym: "cell-cell signalling resulting in cell fate commitment" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0045165 ! cell fate commitment
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0045184
name: establishment of protein localization
namespace: biological_process
def: "The directed movement of a protein to a specific location." [GOC:bf]
synonym: "establishment of protein localisation" EXACT [GOC:mah]
synonym: "protein positioning" EXACT []
synonym: "protein recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: has_primary_input CHEBI:36080 ! protein
relationship: has_primary_input CHEBI:36080 ! protein

[Term]
id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043339
alt_id: GO:0043342
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]
synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
alt_id: GO:0043340
alt_id: GO:0043343
def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "establishment of neuroblast cell polarity" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: occurs_in CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: occurs_in CL:0000031 ! neuroblast (sensu Vertebrata)

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]
subset: goslim_agr
subset: goslim_drosophila
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_synapse
synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124]
synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497]
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0030054 ! cell junction
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0045214
name: sarcomere organization
namespace: biological_process
alt_id: GO:0006938
def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
synonym: "sarcomere alignment" EXACT []
synonym: "sarcomere organisation" EXACT []
is_a: GO:0031032 ! actomyosin structure organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0030017 ! sarcomere
relationship: part_of GO:0030239 ! myofibril assembly
relationship: results_in_organization_of GO:0030017 ! sarcomere

[Term]
id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "cell-cell junction assembly and maintenance" EXACT []
synonym: "cell-cell junction biogenesis" RELATED []
synonym: "cell-cell junction organisation" EXACT [GOC:mah]
synonym: "intercellular junction assembly and maintenance" EXACT []
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0034330 ! cell junction organization
intersection_of: results_in_organization_of GO:0005911 ! cell-cell junction
relationship: results_in_organization_of GO:0005911 ! cell-cell junction

[Term]
id: GO:0045222
name: CD4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732]
synonym: "CD4 anabolism" EXACT []
synonym: "CD4 biosynthesis" EXACT []
synonym: "CD4 formation" EXACT []
synonym: "CD4 synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0019538 ! protein metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output PR:000001004 ! CD4 molecule
relationship: has_primary_output PR:000001004 ! CD4 molecule

[Term]
id: GO:0045223
name: regulation of CD4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "regulation of CD4 anabolism" EXACT []
synonym: "regulation of CD4 biosynthesis" EXACT []
synonym: "regulation of CD4 biosynthetic process" EXACT []
synonym: "regulation of CD4 formation" EXACT []
synonym: "regulation of CD4 synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045222 ! CD4 biosynthetic process
relationship: regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045224
name: positive regulation of CD4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "activation of CD4 biosynthetic process" NARROW []
synonym: "positive regulation of CD4 anabolism" EXACT []
synonym: "positive regulation of CD4 biosynthesis" EXACT []
synonym: "positive regulation of CD4 biosynthetic process" EXACT []
synonym: "positive regulation of CD4 formation" EXACT []
synonym: "positive regulation of CD4 synthesis" EXACT []
synonym: "stimulation of CD4 biosynthetic process" NARROW []
synonym: "up regulation of CD4 biosynthetic process" EXACT []
synonym: "up-regulation of CD4 biosynthetic process" EXACT []
synonym: "upregulation of CD4 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 production
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045225
name: negative regulation of CD4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "down regulation of CD4 biosynthetic process" EXACT []
synonym: "down-regulation of CD4 biosynthetic process" EXACT []
synonym: "downregulation of CD4 biosynthetic process" EXACT []
synonym: "inhibition of CD4 biosynthetic process" NARROW []
synonym: "negative regulation of CD4 anabolism" EXACT []
synonym: "negative regulation of CD4 biosynthesis" EXACT []
synonym: "negative regulation of CD4 biosynthetic process" EXACT []
synonym: "negative regulation of CD4 formation" EXACT []
synonym: "negative regulation of CD4 synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 production
is_a: GO:0051248 ! negative regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045222 ! CD4 biosynthetic process
relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "external encapsulating structure organisation" EXACT []
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0030312 ! external encapsulating structure
relationship: results_in_organization_of GO:0030312 ! external encapsulating structure

[Term]
id: GO:0045321
name: leukocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]
synonym: "immune cell activation" EXACT []
synonym: "leucocyte activation" EXACT []
xref: Wikipedia:Immunologic_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000738 ! leukocyte
relationship: has_primary_input CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: GO:0045444
name: fat cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators]
synonym: "adipocyte cell differentiation" EXACT []
synonym: "adipocyte differentiation" EXACT []
synonym: "adipogenesis" RELATED []
synonym: "adipose cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000136 ! adipocyte
relationship: results_in_acquisition_of_features_of CL:0000136 ! adipocyte

[Term]
id: GO:0045445
name: myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "myoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000056 ! myoblast
relationship: part_of GO:0061061 ! muscle structure development
relationship: results_in_acquisition_of_features_of CL:0000056 ! myoblast

[Term]
id: GO:0045446
name: endothelial cell differentiation
namespace: biological_process
def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000115 ! endothelial cell
relationship: part_of GO:0003158 ! endothelium development
relationship: results_in_acquisition_of_features_of CL:0000115 ! endothelial cell

[Term]
id: GO:0045580
name: regulation of T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of T cell development" RELATED [GOC:add]
synonym: "regulation of T lymphocyte differentiation" EXACT []
synonym: "regulation of T-cell differentiation" EXACT []
synonym: "regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030217 ! T cell differentiation
relationship: regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045581
name: negative regulation of T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of T cell differentiation" EXACT []
synonym: "down-regulation of T cell differentiation" EXACT []
synonym: "downregulation of T cell differentiation" EXACT []
synonym: "inhibition of T cell differentiation" NARROW []
synonym: "negative regulation of T cell development" RELATED [GOC:add]
synonym: "negative regulation of T lymphocyte differentiation" EXACT []
synonym: "negative regulation of T-cell differentiation" EXACT []
synonym: "negative regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050868 ! negative regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030217 ! T cell differentiation
relationship: negatively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of T cell differentiation" NARROW []
synonym: "positive regulation of T cell development" RELATED [GOC:add]
synonym: "positive regulation of T lymphocyte differentiation" EXACT []
synonym: "positive regulation of T-cell differentiation" EXACT []
synonym: "positive regulation of T-lymphocyte differentiation" EXACT []
synonym: "stimulation of T cell differentiation" NARROW []
synonym: "up regulation of T cell differentiation" EXACT []
synonym: "up-regulation of T cell differentiation" EXACT []
synonym: "upregulation of T cell differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030217 ! T cell differentiation
relationship: positively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045595
name: regulation of cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030154 ! cell differentiation
relationship: regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045596
name: negative regulation of cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "down regulation of cell differentiation" EXACT []
synonym: "down-regulation of cell differentiation" EXACT []
synonym: "downregulation of cell differentiation" EXACT []
synonym: "inhibition of cell differentiation" NARROW []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030154 ! cell differentiation
relationship: negatively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]
synonym: "activation of cell differentiation" NARROW []
synonym: "stimulation of cell differentiation" NARROW []
synonym: "up regulation of cell differentiation" EXACT []
synonym: "up-regulation of cell differentiation" EXACT []
synonym: "upregulation of cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030154 ! cell differentiation
relationship: positively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045598
name: regulation of fat cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "regulation of adipocyte cell differentiation" EXACT []
synonym: "regulation of adipocyte differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045444 ! fat cell differentiation
relationship: regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045599
name: negative regulation of fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "down regulation of fat cell differentiation" EXACT []
synonym: "down-regulation of fat cell differentiation" EXACT []
synonym: "downregulation of fat cell differentiation" EXACT []
synonym: "inhibition of fat cell differentiation" NARROW []
synonym: "negative regulation of adipocyte cell differentiation" EXACT []
synonym: "negative regulation of adipocyte differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045444 ! fat cell differentiation
relationship: negatively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045600
name: positive regulation of fat cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "activation of fat cell differentiation" NARROW []
synonym: "positive regulation of adipocyte cell differentiation" EXACT []
synonym: "positive regulation of adipocyte differentiation" EXACT []
synonym: "stimulation of fat cell differentiation" NARROW []
synonym: "up regulation of fat cell differentiation" EXACT []
synonym: "up-regulation of fat cell differentiation" EXACT []
synonym: "upregulation of fat cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045444 ! fat cell differentiation
relationship: positively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045601
name: regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045446 ! endothelial cell differentiation
relationship: regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045602
name: negative regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "down regulation of endothelial cell differentiation" EXACT []
synonym: "down-regulation of endothelial cell differentiation" EXACT []
synonym: "downregulation of endothelial cell differentiation" EXACT []
synonym: "inhibition of endothelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045446 ! endothelial cell differentiation
relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045603
name: positive regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "activation of endothelial cell differentiation" NARROW []
synonym: "stimulation of endothelial cell differentiation" NARROW []
synonym: "up regulation of endothelial cell differentiation" EXACT []
synonym: "up-regulation of endothelial cell differentiation" EXACT []
synonym: "upregulation of endothelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045446 ! endothelial cell differentiation
relationship: positively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045604
name: regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045682 ! regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009913 ! epidermal cell differentiation
relationship: regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045605
name: negative regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "down regulation of epidermal cell differentiation" EXACT []
synonym: "down-regulation of epidermal cell differentiation" EXACT []
synonym: "downregulation of epidermal cell differentiation" EXACT []
synonym: "inhibition of epidermal cell differentiation" NARROW []
synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045683 ! negative regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009913 ! epidermal cell differentiation
relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045606
name: positive regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "activation of epidermal cell differentiation" NARROW []
synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermal cell differentiation" NARROW []
synonym: "up regulation of epidermal cell differentiation" EXACT []
synonym: "up-regulation of epidermal cell differentiation" EXACT []
synonym: "upregulation of epidermal cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045684 ! positive regulation of epidermis development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009913 ! epidermal cell differentiation
relationship: positively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0051249 ! regulation of lymphocyte activation
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030098 ! lymphocyte differentiation
relationship: regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045620
name: negative regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of lymphocyte differentiation" EXACT []
synonym: "down-regulation of lymphocyte differentiation" EXACT []
synonym: "downregulation of lymphocyte differentiation" EXACT []
synonym: "inhibition of lymphocyte differentiation" NARROW []
synonym: "negative regulation of lymphocyte development" RELATED [GOC:add]
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030098 ! lymphocyte differentiation
relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of lymphocyte differentiation" NARROW []
synonym: "positive regulation of lymphocyte development" RELATED [GOC:add]
synonym: "stimulation of lymphocyte differentiation" NARROW []
synonym: "up regulation of lymphocyte differentiation" EXACT []
synonym: "up-regulation of lymphocyte differentiation" EXACT []
synonym: "upregulation of lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030098 ! lymphocyte differentiation
relationship: positively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045637
name: regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030099 ! myeloid cell differentiation
relationship: regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045638
name: negative regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "down regulation of myeloid cell differentiation" EXACT []
synonym: "down-regulation of myeloid cell differentiation" EXACT []
synonym: "downregulation of myeloid cell differentiation" EXACT []
synonym: "inhibition of myeloid cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030099 ! myeloid cell differentiation
relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045639
name: positive regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "activation of myeloid cell differentiation" NARROW []
synonym: "stimulation of myeloid cell differentiation" NARROW []
synonym: "up regulation of myeloid cell differentiation" EXACT []
synonym: "up-regulation of myeloid cell differentiation" EXACT []
synonym: "upregulation of myeloid cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030099 ! myeloid cell differentiation
relationship: positively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045646
name: regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030218 ! erythrocyte differentiation
relationship: regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045647
name: negative regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "down regulation of erythrocyte differentiation" EXACT []
synonym: "down-regulation of erythrocyte differentiation" EXACT []
synonym: "downregulation of erythrocyte differentiation" EXACT []
synonym: "inhibition of erythrocyte differentiation" NARROW []
synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030218 ! erythrocyte differentiation
relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045648
name: positive regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "activation of erythrocyte differentiation" NARROW []
synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232]
synonym: "stimulation of erythrocyte differentiation" NARROW []
synonym: "up regulation of erythrocyte differentiation" EXACT []
synonym: "up-regulation of erythrocyte differentiation" EXACT []
synonym: "upregulation of erythrocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030218 ! erythrocyte differentiation
relationship: positively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045652
name: regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030219 ! megakaryocyte differentiation
relationship: regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045653
name: negative regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "down regulation of megakaryocyte differentiation" EXACT []
synonym: "down-regulation of megakaryocyte differentiation" EXACT []
synonym: "downregulation of megakaryocyte differentiation" EXACT []
synonym: "inhibition of megakaryocyte differentiation" NARROW []
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030219 ! megakaryocyte differentiation
relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045654
name: positive regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "activation of megakaryocyte differentiation" NARROW []
synonym: "stimulation of megakaryocyte differentiation" NARROW []
synonym: "up regulation of megakaryocyte differentiation" EXACT []
synonym: "up-regulation of megakaryocyte differentiation" EXACT []
synonym: "upregulation of megakaryocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030219 ! megakaryocyte differentiation
relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045661
name: regulation of myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045445 ! myoblast differentiation
relationship: regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045662
name: negative regulation of myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "down regulation of myoblast differentiation" EXACT []
synonym: "down-regulation of myoblast differentiation" EXACT []
synonym: "downregulation of myoblast differentiation" EXACT []
synonym: "inhibition of myoblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045445 ! myoblast differentiation
relationship: negatively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045663
name: positive regulation of myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "activation of myoblast differentiation" NARROW []
synonym: "stimulation of myoblast differentiation" NARROW []
synonym: "up regulation of myoblast differentiation" EXACT []
synonym: "up-regulation of myoblast differentiation" EXACT []
synonym: "upregulation of myoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045661 ! regulation of myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045445 ! myoblast differentiation
relationship: positively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045664
name: regulation of neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030182 ! neuron differentiation
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045665
name: negative regulation of neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "down regulation of neuron differentiation" EXACT []
synonym: "down-regulation of neuron differentiation" EXACT []
synonym: "downregulation of neuron differentiation" EXACT []
synonym: "inhibition of neuron differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030182 ! neuron differentiation
relationship: negatively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045666
name: positive regulation of neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "activation of neuron differentiation" NARROW []
synonym: "stimulation of neuron differentiation" NARROW []
synonym: "up regulation of neuron differentiation" EXACT []
synonym: "up-regulation of neuron differentiation" EXACT []
synonym: "upregulation of neuron differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030182 ! neuron differentiation
relationship: positively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045682
name: regulation of epidermis development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "regulation of epidermal development" EXACT []
synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008544 ! epidermis development
relationship: regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045683
name: negative regulation of epidermis development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "down regulation of epidermis development" EXACT []
synonym: "down-regulation of epidermis development" EXACT []
synonym: "downregulation of epidermis development" EXACT []
synonym: "inhibition of epidermis development" NARROW []
synonym: "negative regulation of epidermal development" EXACT []
synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008544 ! epidermis development
relationship: negatively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045684
name: positive regulation of epidermis development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "activation of epidermis development" NARROW []
synonym: "positive regulation of epidermal development" EXACT []
synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermis development" NARROW []
synonym: "up regulation of epidermis development" EXACT []
synonym: "up-regulation of epidermis development" EXACT []
synonym: "upregulation of epidermis development" EXACT []
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008544 ! epidermis development
relationship: positively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045685
name: regulation of glial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "regulation of glia cell differentiation" EXACT []
synonym: "regulation of neuroglia differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010001 ! glial cell differentiation
relationship: regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045686
name: negative regulation of glial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "down regulation of glial cell differentiation" EXACT []
synonym: "down-regulation of glial cell differentiation" EXACT []
synonym: "downregulation of glial cell differentiation" EXACT []
synonym: "inhibition of glial cell differentiation" NARROW []
synonym: "negative regulation of glia cell differentiation" EXACT []
synonym: "negative regulation of neuroglia differentiation" EXACT []
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010001 ! glial cell differentiation
relationship: negatively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045687
name: positive regulation of glial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "activation of glial cell differentiation" NARROW []
synonym: "positive regulation of glia cell differentiation" EXACT []
synonym: "positive regulation of neuroglia differentiation" EXACT []
synonym: "stimulation of glial cell differentiation" NARROW []
synonym: "up regulation of glial cell differentiation" EXACT []
synonym: "up-regulation of glial cell differentiation" EXACT []
synonym: "upregulation of glial cell differentiation" EXACT []
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010001 ! glial cell differentiation
relationship: positively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045700
name: regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:1903353 ! regulation of nucleus organization
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007289 ! spermatid nucleus differentiation
relationship: regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045701
name: negative regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "down regulation of spermatid nuclear differentiation" EXACT []
synonym: "down-regulation of spermatid nuclear differentiation" EXACT []
synonym: "downregulation of spermatid nuclear differentiation" EXACT []
synonym: "inhibition of spermatid nuclear differentiation" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007289 ! spermatid nucleus differentiation
relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045702
name: positive regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "activation of spermatid nuclear differentiation" NARROW []
synonym: "stimulation of spermatid nuclear differentiation" NARROW []
synonym: "up regulation of spermatid nuclear differentiation" EXACT []
synonym: "up-regulation of spermatid nuclear differentiation" EXACT []
synonym: "upregulation of spermatid nuclear differentiation" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007289 ! spermatid nucleus differentiation
relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045719
name: negative regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "down regulation of glycogen biosynthetic process" EXACT []
synonym: "down-regulation of glycogen biosynthetic process" EXACT []
synonym: "downregulation of glycogen biosynthetic process" EXACT []
synonym: "inhibition of glycogen biosynthetic process" NARROW []
synonym: "negative regulation of glycogen anabolism" EXACT []
synonym: "negative regulation of glycogen biosynthesis" EXACT []
synonym: "negative regulation of glycogen formation" EXACT []
synonym: "negative regulation of glycogen synthesis" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005978 ! glycogen biosynthetic process
relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045721
name: negative regulation of gluconeogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
synonym: "down regulation of gluconeogenesis" EXACT []
synonym: "down-regulation of gluconeogenesis" EXACT []
synonym: "downregulation of gluconeogenesis" EXACT []
synonym: "inhibition of gluconeogenesis" NARROW []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006094 ! gluconeogenesis
relationship: negatively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045722
name: positive regulation of gluconeogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
synonym: "activation of gluconeogenesis" NARROW []
synonym: "stimulation of gluconeogenesis" NARROW []
synonym: "up regulation of gluconeogenesis" EXACT []
synonym: "up-regulation of gluconeogenesis" EXACT []
synonym: "upregulation of gluconeogenesis" EXACT []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006094 ! gluconeogenesis
relationship: positively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045724
name: positive regulation of cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]
synonym: "activation of cilium assembly" NARROW []
synonym: "positive regulation of flagellum assembly" BROAD []
synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cilium assembly" NARROW []
synonym: "up regulation of cilium assembly" EXACT []
synonym: "up-regulation of cilium assembly" EXACT []
synonym: "upregulation of cilium assembly" EXACT []
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902117 ! positive regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060271 ! cilium assembly
relationship: positively_regulates GO:0060271 ! cilium assembly

[Term]
id: GO:0045725
name: positive regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
synonym: "activation of glycogen biosynthetic process" NARROW []
synonym: "positive regulation of glycogen anabolism" EXACT []
synonym: "positive regulation of glycogen biosynthesis" EXACT []
synonym: "positive regulation of glycogen formation" EXACT []
synonym: "positive regulation of glycogen synthesis" EXACT []
synonym: "stimulation of glycogen biosynthetic process" NARROW []
synonym: "up regulation of glycogen biosynthetic process" EXACT []
synonym: "up-regulation of glycogen biosynthetic process" EXACT []
synonym: "upregulation of glycogen biosynthetic process" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005978 ! glycogen biosynthetic process
relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045727
name: positive regulation of translation
namespace: biological_process
alt_id: GO:0045946
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of protein biosynthetic process" NARROW []
synonym: "positive regulation of protein anabolism" EXACT []
synonym: "positive regulation of protein biosynthesis" EXACT []
synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb]
synonym: "positive regulation of protein formation" EXACT []
synonym: "positive regulation of protein synthesis" EXACT []
synonym: "stimulation of protein biosynthetic process" NARROW []
synonym: "up regulation of protein biosynthetic process" EXACT []
synonym: "up-regulation of protein biosynthetic process" EXACT []
synonym: "upregulation of protein biosynthetic process" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0034250 ! positive regulation of amide metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006412 ! translation
relationship: positively_regulates GO:0006412 ! translation

[Term]
id: GO:0045732
name: positive regulation of protein catabolic process
namespace: biological_process
alt_id: GO:1903364
alt_id: GO:2000600
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie]
synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie]
synonym: "activation of protein catabolic process" NARROW []
synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein catabolic process" EXACT []
synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol]
synonym: "positive regulation of cyclin catabolic process" NARROW []
synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol]
synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol]
synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol]
synonym: "positive regulation of protein breakdown" EXACT []
synonym: "positive regulation of protein catabolism" EXACT []
synonym: "positive regulation of protein degradation" EXACT []
synonym: "stimulation of protein catabolic process" NARROW []
synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein catabolic process" EXACT []
synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process" EXACT []
synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030163 ! protein catabolic process
relationship: positively_regulates GO:0030163 ! protein catabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0045733
name: acetate catabolic process
namespace: biological_process
alt_id: GO:0019663
def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "acetate breakdown" EXACT []
synonym: "acetate catabolism" EXACT []
synonym: "acetate degradation" EXACT []
synonym: "homoacetate catabolic process" RELATED []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0072329 ! monocarboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:30089 ! acetate
relationship: has_primary_input CHEBI:30089 ! acetate

[Term]
id: GO:0045734
name: regulation of acetate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
synonym: "regulation of acetate breakdown" EXACT []
synonym: "regulation of acetate catabolism" EXACT []
synonym: "regulation of acetate degradation" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045733 ! acetate catabolic process
relationship: regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045753
name: negative regulation of acetate catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "down regulation of acetate catabolic process" EXACT []
synonym: "down-regulation of acetate catabolic process" EXACT []
synonym: "downregulation of acetate catabolic process" EXACT []
synonym: "inhibition of acetate catabolic process" NARROW []
synonym: "negative regulation of acetate breakdown" EXACT []
synonym: "negative regulation of acetate catabolism" EXACT []
synonym: "negative regulation of acetate degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045733 ! acetate catabolic process
relationship: negatively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045754
name: positive regulation of acetate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
synonym: "activation of acetate catabolic process" NARROW []
synonym: "positive regulation of acetate breakdown" EXACT []
synonym: "positive regulation of acetate catabolism" EXACT []
synonym: "positive regulation of acetate degradation" EXACT []
synonym: "stimulation of acetate catabolic process" NARROW []
synonym: "up regulation of acetate catabolic process" EXACT []
synonym: "up-regulation of acetate catabolic process" EXACT []
synonym: "upregulation of acetate catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045733 ! acetate catabolic process
relationship: positively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045759
name: negative regulation of action potential
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "down regulation of action potential" EXACT []
synonym: "down-regulation of action potential" EXACT []
synonym: "downregulation of action potential" EXACT []
synonym: "inhibition of action potential" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001508 ! action potential
relationship: negatively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045760
name: positive regulation of action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators]
synonym: "activation of action potential" NARROW []
synonym: "stimulation of action potential" NARROW []
synonym: "up regulation of action potential" EXACT []
synonym: "up-regulation of action potential" EXACT []
synonym: "upregulation of action potential" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001508 ! action potential
relationship: positively_regulates GO:0001508 ! action potential

[Term]
id: GO:0045763
name: negative regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "down regulation of amino acid metabolic process" EXACT []
synonym: "down-regulation of amino acid metabolic process" EXACT []
synonym: "downregulation of amino acid metabolic process" EXACT []
synonym: "inhibition of amino acid metabolic process" NARROW []
synonym: "negative regulation of amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006520 ! amino acid metabolic process
relationship: negatively_regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0045764
name: positive regulation of amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
synonym: "activation of amino acid metabolic process" NARROW []
synonym: "positive regulation of amino acid metabolism" EXACT []
synonym: "positive regulation of cellular amino acid metabolic process" EXACT []
synonym: "stimulation of amino acid metabolic process" NARROW []
synonym: "up regulation of amino acid metabolic process" EXACT []
synonym: "up-regulation of amino acid metabolic process" EXACT []
synonym: "upregulation of amino acid metabolic process" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006520 ! amino acid metabolic process
relationship: positively_regulates GO:0006520 ! amino acid metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001525 ! angiogenesis
relationship: regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
namespace: biological_process
def: "Any process that activates or increases angiogenesis." [GOC:go_curators]
synonym: "activation of angiogenesis" NARROW []
synonym: "stimulation of angiogenesis" NARROW []
synonym: "up regulation of angiogenesis" EXACT []
synonym: "up-regulation of angiogenesis" EXACT []
synonym: "upregulation of angiogenesis" EXACT []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:1904018 ! positive regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001525 ! angiogenesis
relationship: positively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045769
name: negative regulation of asymmetric cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "down regulation of asymmetric cell division" EXACT []
synonym: "down-regulation of asymmetric cell division" EXACT []
synonym: "downregulation of asymmetric cell division" EXACT []
synonym: "inhibition of asymmetric cell division" NARROW []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051782 ! negative regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008356 ! asymmetric cell division
relationship: negatively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045770
name: positive regulation of asymmetric cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "activation of asymmetric cell division" NARROW []
synonym: "stimulation of asymmetric cell division" NARROW []
synonym: "up regulation of asymmetric cell division" EXACT []
synonym: "up-regulation of asymmetric cell division" EXACT []
synonym: "upregulation of asymmetric cell division" EXACT []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051781 ! positive regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008356 ! asymmetric cell division
relationship: positively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045778
name: positive regulation of ossification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators]
synonym: "activation of ossification" NARROW []
synonym: "positive regulation of bone biosynthesis" EXACT []
synonym: "positive regulation of bone formation" EXACT []
synonym: "stimulation of ossification" NARROW []
synonym: "up regulation of ossification" EXACT []
synonym: "up-regulation of ossification" EXACT []
synonym: "upregulation of ossification" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001503 ! ossification
relationship: positively_regulates GO:0001503 ! ossification

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "activation of cell adhesion" NARROW []
synonym: "stimulation of cell adhesion" NARROW []
synonym: "up regulation of cell adhesion" EXACT []
synonym: "up-regulation of cell adhesion" EXACT []
synonym: "upregulation of cell adhesion" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007155 ! cell adhesion
relationship: positively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0045786
name: negative regulation of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "negative regulation of progression through cell cycle" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007049 ! cell cycle
relationship: negatively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045787
name: positive regulation of cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
synonym: "activation of progression through cell cycle" NARROW []
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through cell cycle" NARROW []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007049 ! cell cycle
relationship: positively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045806
name: negative regulation of endocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "down regulation of endocytosis" EXACT []
synonym: "down-regulation of endocytosis" EXACT []
synonym: "downregulation of endocytosis" EXACT []
synonym: "inhibition of endocytosis" NARROW []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006897 ! endocytosis
relationship: negatively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045807
name: positive regulation of endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "activation of endocytosis" NARROW []
synonym: "stimulation of endocytosis" NARROW []
synonym: "up regulation of endocytosis" EXACT []
synonym: "up-regulation of endocytosis" EXACT []
synonym: "upregulation of endocytosis" EXACT []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051130 ! positive regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006897 ! endocytosis
relationship: positively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045818
name: negative regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "down regulation of glycogen catabolic process" EXACT []
synonym: "down-regulation of glycogen catabolic process" EXACT []
synonym: "downregulation of glycogen catabolic process" EXACT []
synonym: "inhibition of glycogen catabolic process" NARROW []
synonym: "negative regulation of glycogen breakdown" EXACT []
synonym: "negative regulation of glycogen catabolism" EXACT []
synonym: "negative regulation of glycogen degradation" EXACT []
synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl]
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005980 ! glycogen catabolic process
relationship: negatively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045819
name: positive regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
synonym: "activation of glycogen catabolic process" NARROW []
synonym: "positive regulation of glycogen breakdown" EXACT []
synonym: "positive regulation of glycogen catabolism" EXACT []
synonym: "positive regulation of glycogen degradation" EXACT []
synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl]
synonym: "stimulation of glycogen catabolic process" NARROW []
synonym: "up regulation of glycogen catabolic process" EXACT []
synonym: "up-regulation of glycogen catabolic process" EXACT []
synonym: "upregulation of glycogen catabolic process" EXACT []
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005980 ! glycogen catabolic process
relationship: positively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045822
name: negative regulation of heart contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "down regulation of heart contraction" EXACT []
synonym: "down-regulation of heart contraction" EXACT []
synonym: "downregulation of heart contraction" EXACT []
synonym: "inhibition of heart contraction" NARROW []
synonym: "negative regulation of cardiac contraction" RELATED []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903523 ! negative regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060047 ! heart contraction
relationship: negatively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045823
name: positive regulation of heart contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "activation of heart contraction" NARROW []
synonym: "positive regulation of cardiac contraction" EXACT []
synonym: "stimulation of heart contraction" NARROW []
synonym: "up regulation of heart contraction" EXACT []
synonym: "up-regulation of heart contraction" EXACT []
synonym: "upregulation of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:1903524 ! positive regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060047 ! heart contraction
relationship: positively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045833
name: negative regulation of lipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "down regulation of lipid metabolic process" EXACT []
synonym: "down-regulation of lipid metabolic process" EXACT []
synonym: "downregulation of lipid metabolic process" EXACT []
synonym: "inhibition of lipid metabolic process" NARROW []
synonym: "negative regulation of lipid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006629 ! lipid metabolic process
relationship: negatively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045834
name: positive regulation of lipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
synonym: "activation of lipid metabolic process" NARROW []
synonym: "positive regulation of lipid metabolism" EXACT []
synonym: "stimulation of lipid metabolic process" NARROW []
synonym: "up regulation of lipid metabolic process" EXACT []
synonym: "up-regulation of lipid metabolic process" EXACT []
synonym: "upregulation of lipid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006629 ! lipid metabolic process
relationship: positively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045835
name: negative regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
synonym: "negative regulation of meiosis" EXACT []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0140013 ! meiotic nuclear division
relationship: negatively_regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045836
name: positive regulation of meiotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "activation of meiosis" NARROW []
synonym: "positive regulation of meiosis" EXACT []
synonym: "stimulation of meiosis" NARROW []
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
is_a: GO:0040020 ! regulation of meiotic nuclear division
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0140013 ! meiotic nuclear division
relationship: positively_regulates GO:0140013 ! meiotic nuclear division

[Term]
id: GO:0045839
name: negative regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
synonym: "negative regulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0140014 ! mitotic nuclear division
relationship: negatively_regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0045840
name: positive regulation of mitotic nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "positive regulation of mitosis" EXACT []
synonym: "stimulation of mitosis" NARROW []
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitotic nuclear division
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0140014 ! mitotic nuclear division
relationship: positively_regulates GO:0140014 ! mitotic nuclear division

[Term]
id: GO:0045843
name: negative regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "down regulation of striated muscle development" EXACT []
synonym: "down-regulation of striated muscle development" EXACT []
synonym: "downregulation of striated muscle development" EXACT []
synonym: "inhibition of striated muscle development" NARROW []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048635 ! negative regulation of muscle organ development
is_a: GO:1901862 ! negative regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014706 ! striated muscle tissue development
relationship: negatively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045844
name: positive regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "activation of striated muscle development" NARROW []
synonym: "stimulation of striated muscle development" NARROW []
synonym: "up regulation of striated muscle development" EXACT []
synonym: "up-regulation of striated muscle development" EXACT []
synonym: "upregulation of striated muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048636 ! positive regulation of muscle organ development
is_a: GO:1901863 ! positive regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014706 ! striated muscle tissue development
relationship: positively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045900
name: negative regulation of translational elongation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "down regulation of translational elongation" EXACT []
synonym: "down-regulation of translational elongation" EXACT []
synonym: "downregulation of translational elongation" EXACT []
synonym: "inhibition of translational elongation" NARROW []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006414 ! translational elongation
relationship: negatively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045901
name: positive regulation of translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
synonym: "activation of translational elongation" NARROW []
synonym: "stimulation of translational elongation" NARROW []
synonym: "up regulation of translational elongation" EXACT []
synonym: "up-regulation of translational elongation" EXACT []
synonym: "upregulation of translational elongation" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006414 ! translational elongation
relationship: positively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045904
name: negative regulation of translational termination
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "down regulation of translational termination" EXACT []
synonym: "down-regulation of translational termination" EXACT []
synonym: "downregulation of translational termination" EXACT []
synonym: "inhibition of translational termination" NARROW []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006415 ! translational termination
relationship: negatively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045905
name: positive regulation of translational termination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
synonym: "activation of translational termination" NARROW []
synonym: "stimulation of translational termination" NARROW []
synonym: "up regulation of translational termination" EXACT []
synonym: "up-regulation of translational termination" EXACT []
synonym: "upregulation of translational termination" EXACT []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006415 ! translational termination
relationship: positively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045912
name: negative regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "down regulation of carbohydrate metabolic process" EXACT []
synonym: "down-regulation of carbohydrate metabolic process" EXACT []
synonym: "downregulation of carbohydrate metabolic process" EXACT []
synonym: "inhibition of carbohydrate metabolic process" NARROW []
synonym: "negative regulation of carbohydrate metabolism" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005975 ! carbohydrate metabolic process
relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045913
name: positive regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
synonym: "activation of carbohydrate metabolic process" NARROW []
synonym: "positive regulation of carbohydrate metabolism" EXACT []
synonym: "stimulation of carbohydrate metabolic process" NARROW []
synonym: "up regulation of carbohydrate metabolic process" EXACT []
synonym: "up-regulation of carbohydrate metabolic process" EXACT []
synonym: "upregulation of carbohydrate metabolic process" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005975 ! carbohydrate metabolic process
relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045914
name: negative regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
synonym: "down regulation of catecholamine metabolic process" EXACT []
synonym: "down-regulation of catecholamine metabolic process" EXACT []
synonym: "downregulation of catecholamine metabolic process" EXACT []
synonym: "inhibition of catecholamine metabolic process" NARROW []
synonym: "negative regulation of catecholamine metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006584 ! catecholamine metabolic process
relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045915
name: positive regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
synonym: "activation of catecholamine metabolic process" NARROW []
synonym: "positive regulation of catecholamine metabolism" EXACT []
synonym: "stimulation of catecholamine metabolic process" NARROW []
synonym: "up regulation of catecholamine metabolic process" EXACT []
synonym: "up-regulation of catecholamine metabolic process" EXACT []
synonym: "upregulation of catecholamine metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006584 ! catecholamine metabolic process
relationship: positively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045920
name: negative regulation of exocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "down regulation of exocytosis" EXACT []
synonym: "down-regulation of exocytosis" EXACT []
synonym: "downregulation of exocytosis" EXACT []
synonym: "inhibition of exocytosis" NARROW []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006887 ! exocytosis
relationship: negatively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045921
name: positive regulation of exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "activation of exocytosis" NARROW []
synonym: "stimulation of exocytosis" NARROW []
synonym: "up regulation of exocytosis" EXACT []
synonym: "up-regulation of exocytosis" EXACT []
synonym: "upregulation of exocytosis" EXACT []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006887 ! exocytosis
relationship: positively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045926
name: negative regulation of growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "down regulation of growth" EXACT []
synonym: "down-regulation of growth" EXACT []
synonym: "downregulation of growth" EXACT []
synonym: "inhibition of growth" NARROW []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0040007 ! growth
relationship: negatively_regulates GO:0040007 ! growth

[Term]
id: GO:0045927
name: positive regulation of growth
namespace: biological_process
def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
synonym: "activation of growth" NARROW []
synonym: "stimulation of growth" NARROW []
synonym: "up regulation of growth" EXACT []
synonym: "up-regulation of growth" EXACT []
synonym: "upregulation of growth" EXACT []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0040007 ! growth
relationship: positively_regulates GO:0040007 ! growth

[Term]
id: GO:0045930
name: negative regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle
relationship: negatively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045931
name: positive regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle
relationship: positively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045932
name: negative regulation of muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "down regulation of muscle contraction" EXACT []
synonym: "down-regulation of muscle contraction" EXACT []
synonym: "downregulation of muscle contraction" EXACT []
synonym: "inhibition of muscle contraction" NARROW []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006936 ! muscle contraction
relationship: negatively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045933
name: positive regulation of muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "activation of muscle contraction" NARROW []
synonym: "stimulation of muscle contraction" NARROW []
synonym: "up regulation of muscle contraction" EXACT []
synonym: "up-regulation of muscle contraction" EXACT []
synonym: "upregulation of muscle contraction" EXACT []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006936 ! muscle contraction
relationship: positively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045934
name: negative regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045935
name: positive regulation of nucleobase-containing compound metabolic process
namespace: biological_process
def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process
relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process

[Term]
id: GO:0045936
name: negative regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "down regulation of phosphate metabolic process" EXACT []
synonym: "down-regulation of phosphate metabolic process" EXACT []
synonym: "downregulation of phosphate metabolic process" EXACT []
synonym: "inhibition of phosphate metabolic process" NARROW []
synonym: "negative regulation of phosphate metabolism" EXACT []
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045937
name: positive regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
synonym: "activation of phosphate metabolic process" NARROW []
synonym: "positive regulation of phosphate metabolism" EXACT []
synonym: "stimulation of phosphate metabolic process" NARROW []
synonym: "up regulation of phosphate metabolic process" EXACT []
synonym: "up-regulation of phosphate metabolic process" EXACT []
synonym: "upregulation of phosphate metabolic process" EXACT []
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process
relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process

[Term]
id: GO:0045939
name: negative regulation of steroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "down regulation of steroid metabolic process" EXACT []
synonym: "down-regulation of steroid metabolic process" EXACT []
synonym: "downregulation of steroid metabolic process" EXACT []
synonym: "inhibition of steroid metabolic process" NARROW []
synonym: "negative regulation of steroid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008202 ! steroid metabolic process
relationship: negatively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045940
name: positive regulation of steroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
synonym: "activation of steroid metabolic process" NARROW []
synonym: "positive regulation of steroid metabolism" EXACT []
synonym: "stimulation of steroid metabolic process" NARROW []
synonym: "up regulation of steroid metabolic process" EXACT []
synonym: "up-regulation of steroid metabolic process" EXACT []
synonym: "upregulation of steroid metabolic process" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008202 ! steroid metabolic process
relationship: positively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045947
name: negative regulation of translational initiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "down regulation of translational initiation" EXACT []
synonym: "down-regulation of translational initiation" EXACT []
synonym: "downregulation of translational initiation" EXACT []
synonym: "inhibition of translational initiation" NARROW []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0017148 ! negative regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006413 ! translational initiation
relationship: negatively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045948
name: positive regulation of translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
synonym: "activation of translational initiation" NARROW []
synonym: "stimulation of translational initiation" NARROW []
synonym: "up regulation of translational initiation" EXACT []
synonym: "up-regulation of translational initiation" EXACT []
synonym: "upregulation of translational initiation" EXACT []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0045727 ! positive regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006413 ! translational initiation
relationship: positively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045986
name: negative regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of smooth muscle contraction" EXACT []
synonym: "down-regulation of smooth muscle contraction" EXACT []
synonym: "downregulation of smooth muscle contraction" EXACT []
synonym: "inhibition of smooth muscle contraction" NARROW []
synonym: "smooth muscle relaxation" RELATED []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006939 ! smooth muscle contraction
relationship: negatively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045987
name: positive regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "activation of smooth muscle contraction" NARROW []
synonym: "stimulation of smooth muscle contraction" NARROW []
synonym: "up regulation of smooth muscle contraction" EXACT []
synonym: "up-regulation of smooth muscle contraction" EXACT []
synonym: "upregulation of smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006939 ! smooth muscle contraction
relationship: positively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045988
name: negative regulation of striated muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "down regulation of striated muscle contraction" EXACT []
synonym: "down-regulation of striated muscle contraction" EXACT []
synonym: "downregulation of striated muscle contraction" EXACT []
synonym: "inhibition of striated muscle contraction" NARROW []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006941 ! striated muscle contraction
relationship: negatively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045989
name: positive regulation of striated muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "activation of striated muscle contraction" NARROW []
synonym: "stimulation of striated muscle contraction" NARROW []
synonym: "up regulation of striated muscle contraction" EXACT []
synonym: "up-regulation of striated muscle contraction" EXACT []
synonym: "upregulation of striated muscle contraction" EXACT []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006941 ! striated muscle contraction
relationship: positively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045992
name: negative regulation of embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "down regulation of embryonic development" EXACT []
synonym: "down-regulation of embryonic development" EXACT []
synonym: "downregulation of embryonic development" EXACT []
synonym: "inhibition of embryonic development" NARROW []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009790 ! embryo development
relationship: negatively_regulates GO:0009790 ! embryo development

[Term]
id: GO:0045995
name: regulation of embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009790 ! embryo development
relationship: regulates GO:0009790 ! embryo development

[Term]
id: GO:0046013
name: regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "regulation of resting T cell proliferation" EXACT []
synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "regulation of T-cell homeostatic proliferation" EXACT []
synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001777 ! T cell homeostatic proliferation
relationship: regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046014
name: negative regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "down regulation of T cell homeostatic proliferation" EXACT []
synonym: "down-regulation of T cell homeostatic proliferation" EXACT []
synonym: "downregulation of T cell homeostatic proliferation" EXACT []
synonym: "inhibition of T cell homeostatic proliferation" NARROW []
synonym: "negative regulation of resting T cell proliferation" EXACT []
synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "negative regulation of T-cell homeostatic proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001777 ! T cell homeostatic proliferation
relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046112
name: nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
synonym: "nucleobase anabolism" EXACT []
synonym: "nucleobase biosynthesis" EXACT []
synonym: "nucleobase formation" EXACT []
synonym: "nucleobase synthesis" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:18282 ! nucleobase
relationship: has_primary_output CHEBI:18282 ! nucleobase

[Term]
id: GO:0046113
name: nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
synonym: "nucleobase breakdown" EXACT []
synonym: "nucleobase catabolism" EXACT []
synonym: "nucleobase degradation" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:1901361 ! organic cyclic compound catabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:18282 ! nucleobase
relationship: has_primary_input CHEBI:18282 ! nucleobase

[Term]
id: GO:0046189
name: phenol-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai]
synonym: "phenol-containing compound anabolism" EXACT []
synonym: "phenol-containing compound biosynthesis" EXACT []
synonym: "phenol-containing compound formation" EXACT []
synonym: "phenol-containing compound synthesis" EXACT []
is_a: GO:0018958 ! phenol-containing compound metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:1901362 ! organic cyclic compound biosynthetic process
is_a: GO:1901617 ! organic hydroxy compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33853 ! phenols
relationship: has_primary_output CHEBI:33853 ! phenols

[Term]
id: GO:0046219
name: indolalkylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators]
synonym: "indolalkylamine anabolism" EXACT []
synonym: "indolalkylamine biosynthesis" EXACT []
synonym: "indolalkylamine formation" EXACT []
synonym: "indolalkylamine synthesis" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0042401 ! biogenic amine biosynthetic process
is_a: GO:0042435 ! indole-containing compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:38631 ! aminoalkylindole
relationship: has_primary_output CHEBI:38631 ! aminoalkylindole

[Term]
id: GO:0046348
name: amino sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators]
synonym: "amino sugar breakdown" EXACT []
synonym: "amino sugar catabolism" EXACT []
synonym: "amino sugar degradation" EXACT []
synonym: "aminosaccharide catabolic process" EXACT []
synonym: "aminosaccharide catabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901136 ! carbohydrate derivative catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:28963 ! amino sugar
relationship: has_primary_input CHEBI:28963 ! amino sugar

[Term]
id: GO:0046349
name: amino sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators]
synonym: "amino sugar anabolism" EXACT []
synonym: "amino sugar biosynthesis" EXACT []
synonym: "amino sugar formation" EXACT []
synonym: "amino sugar synthesis" EXACT []
synonym: "aminosaccharide biosynthesis" EXACT []
synonym: "aminosaccharide biosynthetic process" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:1901137 ! carbohydrate derivative biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:28963 ! amino sugar
relationship: has_primary_output CHEBI:28963 ! amino sugar

[Term]
id: GO:0046364
name: monosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
synonym: "monosaccharide anabolism" EXACT []
synonym: "monosaccharide biosynthesis" EXACT []
synonym: "monosaccharide formation" EXACT []
synonym: "monosaccharide synthesis" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:35381 ! monosaccharide
relationship: has_primary_output CHEBI:35381 ! monosaccharide

[Term]
id: GO:0046365
name: monosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732]
synonym: "monosaccharide breakdown" EXACT []
synonym: "monosaccharide catabolism" EXACT []
synonym: "monosaccharide degradation" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044282 ! small molecule catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:35381 ! monosaccharide
relationship: has_primary_input CHEBI:35381 ! monosaccharide

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid anabolism" EXACT []
synonym: "carboxylic acid biosynthesis" EXACT []
synonym: "carboxylic acid formation" EXACT []
synonym: "carboxylic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:29067 ! carboxylic acid anion
relationship: has_primary_output CHEBI:29067 ! carboxylic acid anion

[Term]
id: GO:0046395
name: carboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]
synonym: "carboxylic acid breakdown" EXACT []
synonym: "carboxylic acid catabolism" EXACT []
synonym: "carboxylic acid degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion
relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion

[Term]
id: GO:0046483
name: heterocycle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]
subset: goslim_pir
synonym: "heterocycle metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:5686 ! heterocyclic compound
relationship: has_primary_input_or_output CHEBI:5686 ! heterocyclic compound

[Term]
id: GO:0046530
name: photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0007467
def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000210 ! photoreceptor cell
relationship: results_in_acquisition_of_features_of CL:0000210 ! photoreceptor cell

[Term]
id: GO:0046532
name: regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045673
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046530 ! photoreceptor cell differentiation
relationship: regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046533
name: negative regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045674
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "down regulation of photoreceptor cell differentiation" EXACT []
synonym: "down regulation of photoreceptor differentiation" EXACT []
synonym: "down-regulation of photoreceptor cell differentiation" EXACT []
synonym: "down-regulation of photoreceptor differentiation" EXACT []
synonym: "downregulation of photoreceptor cell differentiation" EXACT []
synonym: "downregulation of photoreceptor differentiation" EXACT []
synonym: "inhibition of photoreceptor cell differentiation" NARROW []
synonym: "inhibition of photoreceptor differentiation" NARROW []
synonym: "negative regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046530 ! photoreceptor cell differentiation
relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046534
name: positive regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045675
def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "activation of photoreceptor cell differentiation" NARROW []
synonym: "activation of photoreceptor differentiation" NARROW []
synonym: "positive regulation of photoreceptor differentiation" EXACT []
synonym: "stimulation of photoreceptor cell differentiation" NARROW []
synonym: "stimulation of photoreceptor differentiation" NARROW []
synonym: "up regulation of photoreceptor cell differentiation" EXACT []
synonym: "up regulation of photoreceptor differentiation" EXACT []
synonym: "up-regulation of photoreceptor cell differentiation" EXACT []
synonym: "up-regulation of photoreceptor differentiation" EXACT []
synonym: "upregulation of photoreceptor cell differentiation" EXACT []
synonym: "upregulation of photoreceptor differentiation" EXACT []
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046530 ! photoreceptor cell differentiation
relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046545
name: development of primary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0046546
name: development of primary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046548
name: retinal rod cell development
namespace: biological_process
def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000604 ! retinal rod cell
relationship: part_of GO:0060221 ! retinal rod cell differentiation
relationship: results_in_development_of CL:0000604 ! retinal rod cell

[Term]
id: GO:0046549
name: retinal cone cell development
namespace: biological_process
def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732]
is_a: GO:0042462 ! eye photoreceptor cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000573 ! retinal cone cell
relationship: part_of GO:0042670 ! retinal cone cell differentiation
relationship: results_in_development_of CL:0000573 ! retinal cone cell

[Term]
id: GO:0046620
name: regulation of organ growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035265 ! organ growth
relationship: regulates GO:0035265 ! organ growth

[Term]
id: GO:0046621
name: negative regulation of organ growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035265 ! organ growth
relationship: negatively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046622
name: positive regulation of organ growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035265 ! organ growth
relationship: positively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046649
name: lymphocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000542 ! lymphocyte
relationship: has_primary_input CL:0000542 ! lymphocyte

[Term]
id: GO:0046651
name: lymphocyte proliferation
namespace: biological_process
def: "The expansion of a lymphocyte population by cell division." [GOC:ai]
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000542 ! lymphocyte
relationship: acts_on_population_of CL:0000542 ! lymphocyte

[Term]
id: GO:0046660
name: female sex differentiation
namespace: biological_process
def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046661
name: male sex differentiation
namespace: biological_process
def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organism development

[Term]
id: GO:0046666
name: retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the developing retina." [GOC:bf]
synonym: "programmed cell death, retina cells" EXACT []
synonym: "programmed cell death, retinal cells" EXACT []
synonym: "retina cell programmed cell death" EXACT []
synonym: "retina programmed cell death" EXACT []
synonym: "retinal programmed cell death" EXACT []
is_a: GO:0010623 ! programmed cell death involved in cell development
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0046667
name: compound eye retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
is_a: GO:0046666 ! retinal cell programmed cell death
intersection_of: GO:0046666 ! retinal cell programmed cell death
intersection_of: results_in_maturation_of UBERON:0000018 ! compound eye
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: results_in_maturation_of UBERON:0000018 ! compound eye

[Term]
id: GO:0046668
name: regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046666 ! retinal cell programmed cell death
relationship: regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046669
name: regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046670
name: positive regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "activation of retinal programmed cell death" NARROW []
synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb]
synonym: "stimulation of retinal programmed cell death" NARROW []
synonym: "up regulation of retinal programmed cell death" EXACT []
synonym: "up-regulation of retinal programmed cell death" EXACT []
synonym: "upregulation of retinal programmed cell death" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046666 ! retinal cell programmed cell death
relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046671
name: negative regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "down regulation of retinal programmed cell death" EXACT []
synonym: "down-regulation of retinal programmed cell death" EXACT []
synonym: "downregulation of retinal programmed cell death" EXACT []
synonym: "inhibition of retinal programmed cell death" NARROW []
synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046666 ! retinal cell programmed cell death
relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046672
name: positive regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "activation of retinal cell programmed cell death" BROAD []
synonym: "positive regulation of retinal cell programmed cell death" BROAD []
synonym: "stimulation of retinal cell programmed cell death" BROAD []
synonym: "up regulation of retinal cell programmed cell death" BROAD []
synonym: "up-regulation of retinal cell programmed cell death" BROAD []
synonym: "upregulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046673
name: negative regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "down regulation of retinal cell programmed cell death" BROAD []
synonym: "down-regulation of retinal cell programmed cell death" BROAD []
synonym: "downregulation of retinal cell programmed cell death" BROAD []
synonym: "inhibition of retinal cell programmed cell death" BROAD []
synonym: "negative regulation of retina cell programmed cell death" BROAD []
synonym: "negative regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death
relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046676
name: negative regulation of insulin secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
synonym: "down regulation of insulin secretion" EXACT []
synonym: "down-regulation of insulin secretion" EXACT []
synonym: "downregulation of insulin secretion" EXACT []
synonym: "inhibition of insulin secretion" NARROW []
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030073 ! insulin secretion
relationship: negatively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0046681
name: response to carbamate
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544]
synonym: "carbamate resistance" RELATED []
synonym: "carbamate susceptibility/resistance" RELATED []
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:0017085 ! response to insecticide
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:13941 ! carbamate
relationship: has_primary_input CHEBI:13941 ! carbamate

[Term]
id: GO:0046700
name: heterocycle catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]
synonym: "heterocycle breakdown" EXACT []
synonym: "heterocycle catabolism" EXACT []
synonym: "heterocycle degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0046483 ! heterocycle metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:5686 ! heterocyclic compound
relationship: has_primary_input CHEBI:5686 ! heterocyclic compound

[Term]
id: GO:0046716
name: muscle cell cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb]
synonym: "muscle homeostasis" RELATED [GOC:dph]
is_a: GO:0019725 ! cellular homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: occurs_in CL:0000187 ! muscle cell
relationship: occurs_in CL:0000187 ! muscle cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0046717
name: acid secretion
namespace: biological_process
def: "The controlled release of acid by a cell or a tissue." [GOC:ai]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046785
name: microtubule polymerization
namespace: biological_process
def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]
synonym: "microtubule assembly" EXACT []
synonym: "microtubule formation" RELATED []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005874 ! microtubule
relationship: results_in_assembly_of GO:0005874 ! microtubule
relationship: starts_with GO:0007020 ! microtubule nucleation

[Term]
id: GO:0046873
name: metal ion transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
synonym: "heavy metal ion porter activity" NARROW []
synonym: "heavy metal ion transporter activity" NARROW []
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "heavy metal-exporting ATPase activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
is_a: GO:0008324 ! monoatomic cation transmembrane transporter activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:25213 ! metal cation
relationship: has_primary_input CHEBI:25213 ! metal cation
relationship: part_of GO:0030001 ! metal ion transport

[Term]
id: GO:0046879
name: hormone secretion
namespace: biological_process
def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732]
is_a: GO:0009914 ! hormone transport
is_a: GO:0023061 ! signal release

[Term]
id: GO:0046883
name: regulation of hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0023051 ! regulation of signaling
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046879 ! hormone secretion
relationship: regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046887
name: positive regulation of hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "activation of hormone secretion" NARROW []
synonym: "stimulation of hormone secretion" NARROW []
synonym: "up regulation of hormone secretion" EXACT []
synonym: "up-regulation of hormone secretion" EXACT []
synonym: "upregulation of hormone secretion" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046879 ! hormone secretion
relationship: positively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046888
name: negative regulation of hormone secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]
synonym: "down regulation of hormone secretion" EXACT []
synonym: "down-regulation of hormone secretion" EXACT []
synonym: "downregulation of hormone secretion" EXACT []
synonym: "inhibition of hormone secretion" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046879 ! hormone secretion
relationship: negatively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046889
name: positive regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "activation of lipid biosynthetic process" NARROW []
synonym: "positive regulation of lipid anabolism" EXACT []
synonym: "positive regulation of lipid biosynthesis" EXACT []
synonym: "positive regulation of lipid formation" EXACT []
synonym: "positive regulation of lipid synthesis" EXACT []
synonym: "positive regulation of lipogenesis" EXACT [GOC:sl]
synonym: "stimulation of lipid biosynthetic process" NARROW []
synonym: "up regulation of lipid biosynthetic process" EXACT []
synonym: "up-regulation of lipid biosynthetic process" EXACT []
synonym: "upregulation of lipid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008610 ! lipid biosynthetic process
relationship: positively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046890
name: regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "regulation of lipid anabolism" EXACT []
synonym: "regulation of lipid biosynthesis" EXACT []
synonym: "regulation of lipid formation" EXACT []
synonym: "regulation of lipid synthesis" EXACT []
synonym: "regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008610 ! lipid biosynthetic process
relationship: regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell or a tissue." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport

[Term]
id: GO:0046907
name: intracellular transport
namespace: biological_process
alt_id: GO:1902582
def: "The directed movement of substances within a cell." [GOC:ai]
synonym: "single organism intracellular transport" RELATED [GOC:TermGenie]
synonym: "single-organism intracellular transport" RELATED []
is_a: GO:0006810 ! transport
is_a: GO:0051641 ! cellular localization
is_a: GO:0051649 ! establishment of localization in cell
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
relationship: occurs_in GO:0005622 ! intracellular anatomical structure
created_by: jl
creation_date: 2013-12-18T14:04:50Z

[Term]
id: GO:0046928
name: regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007269 ! neurotransmitter secretion
relationship: regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046929
name: negative regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]
synonym: "conotoxin activity" NARROW []
synonym: "down regulation of neurotransmitter secretion" EXACT []
synonym: "down-regulation of neurotransmitter secretion" EXACT []
synonym: "downregulation of neurotransmitter secretion" EXACT []
synonym: "inhibition of neurotransmitter secretion" NARROW []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007269 ! neurotransmitter secretion
relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046942
name: carboxylic acid transport
namespace: biological_process
def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
is_a: GO:0015711 ! organic anion transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion
relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion

[Term]
id: GO:0046943
name: carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane"
is_a: GO:0008514 ! organic anion transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion
relationship: has_primary_input CHEBI:29067 ! carboxylic acid anion
relationship: part_of GO:1905039 ! carboxylic acid transmembrane transport

[Term]
id: GO:0047496
name: vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]
synonym: "microtubule-based vesicle localization" EXACT [GOC:rl]
is_a: GO:0072384 ! organelle transport along microtubule
is_a: GO:0099518 ! vesicle cytoskeletal trafficking
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input GO:0031982 ! vesicle
intersection_of: results_in_transport_along GO:0005874 ! microtubule

[Term]
id: GO:0048048
name: embryonic eye morphogenesis
namespace: biological_process
def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048066
name: developmental pigmentation
namespace: biological_process
def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]
synonym: "pigmentation during development" RELATED []
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0048070
name: regulation of developmental pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0120305 ! regulation of pigmentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048066 ! developmental pigmentation
relationship: regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048086
name: negative regulation of developmental pigmentation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of pigmentation" NARROW []
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048066 ! developmental pigmentation
relationship: negatively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048087
name: positive regulation of developmental pigmentation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb]
synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb]
synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph]
synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048070 ! regulation of developmental pigmentation
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048066 ! developmental pigmentation
relationship: positively_regulates GO:0048066 ! developmental pigmentation

[Term]
id: GO:0048103
name: somatic stem cell division
namespace: biological_process
def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]
synonym: "somatic stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000723 ! somatic stem cell
relationship: has_primary_input CL:0000723 ! somatic stem cell

[Term]
id: GO:0048132
name: female germ-line stem cell asymmetric division
namespace: biological_process
alt_id: GO:0048141
def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu]
synonym: "female germ-line stem cell renewal" EXACT []
is_a: GO:0098728 ! germline stem cell asymmetric division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: has_primary_input CL:0000022 ! female germ line stem cell
relationship: has_primary_input CL:0000022 ! female germ line stem cell
relationship: in_taxon NCBITaxon:6656 {all_only="true"} ! Arthropoda
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048137
name: spermatocyte division
namespace: biological_process
def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238]
synonym: "spermatocyte cell division" EXACT []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000017 ! spermatocyte
relationship: has_primary_input CL:0000017 ! spermatocyte
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048144
name: fibroblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000057 ! fibroblast
relationship: acts_on_population_of CL:0000057 ! fibroblast

[Term]
id: GO:0048145
name: regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048144 ! fibroblast proliferation
relationship: regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048146
name: positive regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "activation of fibroblast proliferation" NARROW []
synonym: "stimulation of fibroblast proliferation" NARROW []
synonym: "up regulation of fibroblast proliferation" EXACT []
synonym: "up-regulation of fibroblast proliferation" EXACT []
synonym: "upregulation of fibroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048144 ! fibroblast proliferation
relationship: positively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048147
name: negative regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid]
synonym: "down regulation of fibroblast proliferation" EXACT []
synonym: "down-regulation of fibroblast proliferation" EXACT []
synonym: "downregulation of fibroblast proliferation" EXACT []
synonym: "inhibition of fibroblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048144 ! fibroblast proliferation
relationship: negatively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048193
name: Golgi vesicle transport
namespace: biological_process
def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]
subset: goslim_yeast
synonym: "Golgi-derived vesicle transport" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0006810 ! transport
intersection_of: results_in_transport_to_from_or_in GO:0005798 ! Golgi-associated vesicle
relationship: results_in_transport_to_from_or_in GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0048194
name: Golgi vesicle budding
namespace: biological_process
def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle budding" NARROW []
synonym: "Golgi-derived vesicle budding" EXACT []
is_a: GO:0006900 ! vesicle budding from membrane
intersection_of: GO:0006900 ! vesicle budding from membrane
intersection_of: has_primary_output GO:0005798 ! Golgi-associated vesicle
intersection_of: occurs_in GO:0000139 ! Golgi membrane
relationship: has_primary_output GO:0005798 ! Golgi-associated vesicle
relationship: occurs_in GO:0000139 ! Golgi membrane
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048199
name: vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle targeting" NARROW []
synonym: "Golgi vesicle targeting" EXACT []
synonym: "vesicle targeting, to, from or within dictyosome" NARROW []
is_a: GO:0006903 ! vesicle targeting
intersection_of: GO:0006903 ! vesicle targeting
intersection_of: has_primary_input GO:0005798 ! Golgi-associated vesicle
intersection_of: results_in_transport_to_from_or_in GO:0005794 ! Golgi apparatus
relationship: has_primary_input GO:0005798 ! Golgi-associated vesicle
relationship: part_of GO:0048193 ! Golgi vesicle transport
relationship: results_in_transport_to_from_or_in GO:0005794 ! Golgi apparatus

[Term]
id: GO:0048209
name: regulation of vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "regulation of Golgi vesicle targeting" EXACT []
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048232
name: male gamete generation
namespace: biological_process
def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0048240
name: sperm capacitation
namespace: biological_process
def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]
comment: Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract.
synonym: "sperm activation" RELATED [PMID:23180860]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0048243
name: norepinephrine secretion
namespace: biological_process
def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid]
synonym: "noradrenaline secretion" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)

[Term]
id: GO:0048251
name: elastic fiber assembly
namespace: biological_process
def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674]
synonym: "elastic fibre assembly" EXACT []
synonym: "elastin fiber assembly" EXACT [GOC:BHF]
synonym: "elastin fibre assembly" EXACT [GOC:BHF]
is_a: GO:0085029 ! extracellular matrix assembly
is_a: GO:0097435 ! supramolecular fiber organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0071953 ! elastic fiber
relationship: results_in_assembly_of GO:0071953 ! elastic fiber

[Term]
id: GO:0048280
name: vesicle fusion with Golgi apparatus
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0007030 ! Golgi organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0005794 ! Golgi apparatus
intersection_of: results_in_fusion_of GO:0031982 ! vesicle
relationship: part_of GO:0048193 ! Golgi vesicle transport
relationship: results_in_fusion_of GO:0005794 ! Golgi apparatus
relationship: results_in_fusion_of GO:0031982 ! vesicle

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0043226 ! organelle
relationship: results_in_fusion_of GO:0043226 ! organelle

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fission_of GO:0043226 ! organelle
relationship: results_in_fission_of GO:0043226 ! organelle

[Term]
id: GO:0048288
name: nuclear membrane fusion involved in karyogamy
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid]
synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000740 ! nuclear membrane fusion
intersection_of: GO:0000740 ! nuclear membrane fusion
intersection_of: part_of GO:0000741 ! karyogamy
relationship: part_of GO:0000741 ! karyogamy

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048313
name: Golgi inheritance
namespace: biological_process
def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069]
synonym: "Golgi apparatus inheritance" EXACT []
synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi partitioning" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0048308 ! organelle inheritance
intersection_of: GO:0048308 ! organelle inheritance
intersection_of: results_in_distribution_of GO:0005794 ! Golgi apparatus
relationship: results_in_distribution_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0048318
name: axial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003068 ! axial mesoderm
relationship: results_in_development_of UBERON:0003068 ! axial mesoderm

[Term]
id: GO:0048319
name: axial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003068 ! axial mesoderm
relationship: part_of GO:0048318 ! axial mesoderm development
relationship: results_in_morphogenesis_of UBERON:0003068 ! axial mesoderm

[Term]
id: GO:0048320
name: axial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003068 ! axial mesoderm
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003068 ! axial mesoderm

[Term]
id: GO:0048332
name: mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000926 ! mesoderm
relationship: part_of GO:0007498 ! mesoderm development
relationship: results_in_morphogenesis_of UBERON:0000926 ! mesoderm

[Term]
id: GO:0048333
name: mesodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]
synonym: "mesoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000222 ! mesodermal cell
relationship: part_of GO:0001707 ! mesoderm formation
relationship: results_in_acquisition_of_features_of CL:0000222 ! mesodermal cell

[Term]
id: GO:0048339
name: paraxial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003077 ! paraxial mesoderm
relationship: results_in_development_of UBERON:0003077 ! paraxial mesoderm

[Term]
id: GO:0048340
name: paraxial mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003077 ! paraxial mesoderm
relationship: part_of GO:0048339 ! paraxial mesoderm development
relationship: results_in_morphogenesis_of UBERON:0003077 ! paraxial mesoderm

[Term]
id: GO:0048341
name: paraxial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003077 ! paraxial mesoderm
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003077 ! paraxial mesoderm

[Term]
id: GO:0048368
name: lateral mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "lateral plate mesoderm development" EXACT []
is_a: GO:0007498 ! mesoderm development
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003081 ! lateral plate mesoderm
relationship: results_in_development_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: GO:0048369
name: lateral mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators]
synonym: "lateral plate mesoderm morphogenesis" EXACT []
is_a: GO:0048332 ! mesoderm morphogenesis
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003081 ! lateral plate mesoderm
relationship: part_of GO:0048368 ! lateral mesoderm development
relationship: results_in_morphogenesis_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: GO:0048370
name: lateral mesoderm formation
namespace: biological_process
def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid]
synonym: "lateral plate mesoderm biosynthesis" EXACT []
synonym: "lateral plate mesoderm formation" EXACT []
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003081 ! lateral plate mesoderm
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis
relationship: results_in_morphogenesis_of UBERON:0003081 ! lateral plate mesoderm

[Term]
id: GO:0048389
name: intermediate mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003064 ! intermediate mesoderm
relationship: results_in_development_of UBERON:0003064 ! intermediate mesoderm

[Term]
id: GO:0048390
name: intermediate mesoderm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003064 ! intermediate mesoderm
relationship: part_of GO:0048389 ! intermediate mesoderm development
relationship: results_in_morphogenesis_of UBERON:0003064 ! intermediate mesoderm

[Term]
id: GO:0048391
name: intermediate mesoderm formation
namespace: biological_process
def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003064 ! intermediate mesoderm
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003064 ! intermediate mesoderm

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]
subset: goslim_candida
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0048869 ! cellular developmental process
intersection_of: GO:0008150 ! biological process
intersection_of: results_in_development_of CL:0000000 ! cell
relationship: part_of GO:0030154 ! cell differentiation
relationship: results_in_development_of CL:0000000 ! cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000000 ! cell
relationship: part_of GO:0048468 ! cell development
relationship: results_in_maturation_of CL:0000000 ! cell
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24390" xsd:anyURI

[Term]
id: GO:0048477
name: oogenesis
namespace: biological_process
alt_id: GO:0009993
alt_id: GO:0048157
def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]
synonym: "ovum development" EXACT systematic_synonym []
xref: Wikipedia:Oogenesis
is_a: GO:0007281 ! germ cell development
is_a: GO:0007292 ! female gamete generation
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0000025 ! egg cell
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: results_in_development_of CL:0000025 ! egg cell

[Term]
id: GO:0048483
name: autonomic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002410 ! autonomic nervous system
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_development_of UBERON:0002410 ! autonomic nervous system

[Term]
id: GO:0048485
name: sympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000013 ! sympathetic nervous system
relationship: part_of GO:0048483 ! autonomic nervous system development
relationship: results_in_development_of UBERON:0000013 ! sympathetic nervous system

[Term]
id: GO:0048505
name: regulation of timing of cell differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb]
synonym: "timing of cell differentiation" RELATED []
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0045595 ! regulation of cell differentiation

[Term]
id: GO:0048511
name: rhythmic process
namespace: biological_process
def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
subset: goslim_pir
synonym: "rhythm" RELATED []
is_a: GO:0008150 ! biological process
relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms

[Term]
id: GO:0048513
name: animal organ development
namespace: biological_process
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]
synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25943" xsd:anyURI

[Term]
id: GO:0048514
name: blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid]
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001981 ! blood vessel
relationship: part_of GO:0001568 ! blood vessel development
relationship: results_in_morphogenesis_of UBERON:0001981 ! blood vessel

[Term]
id: GO:0048515
name: spermatid differentiation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid]
synonym: "spermatid cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000018 ! spermatid
relationship: part_of GO:0007283 ! spermatogenesis
relationship: results_in_acquisition_of_features_of CL:0000018 ! spermatid

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
alt_id: GO:0043119
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008150 ! biological process
relationship: positively_regulates GO:0008150 ! biological process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
alt_id: GO:0043118
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008150 ! biological process
relationship: negatively_regulates GO:0008150 ! biological process

[Term]
id: GO:0048520
name: positive regulation of behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "activation of behavior" NARROW []
synonym: "stimulation of behavior" NARROW []
synonym: "up regulation of behavior" EXACT []
synonym: "up-regulation of behavior" EXACT []
synonym: "upregulation of behavior" EXACT []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007610 ! behavior
relationship: positively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048521
name: negative regulation of behavior
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr]
synonym: "down regulation of behavior" EXACT []
synonym: "down-regulation of behavior" EXACT []
synonym: "downregulation of behavior" EXACT []
synonym: "inhibition of behavior" NARROW []
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007610 ! behavior
relationship: negatively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
alt_id: GO:0051242
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009987 ! cellular process
relationship: positively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
alt_id: GO:0051243
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]
subset: gocheck_do_not_annotate
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009987 ! cellular process
relationship: negatively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048534
name: hematopoietic or lymphoid organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]
synonym: "haematopoietic or lymphoid organ development" EXACT []
synonym: "haemopoietic or lymphoid organ development" EXACT []
synonym: "hemopoietic or lymphoid organ development" EXACT []
is_a: GO:0048513 ! animal organ development
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0048536
name: spleen development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149]
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002106 ! spleen
relationship: results_in_development_of UBERON:0002106 ! spleen

[Term]
id: GO:0048539
name: bone marrow development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149]
is_a: GO:0009888 ! tissue development
is_a: GO:0048534 ! hematopoietic or lymphoid organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002371 ! bone marrow
relationship: part_of GO:0060348 ! bone development
relationship: results_in_development_of UBERON:0002371 ! bone marrow

[Term]
id: GO:0048545
name: response to steroid hormone
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]
synonym: "response to steroid hormone stimulus" EXACT [GOC:dos]
is_a: GO:0009725 ! response to hormone
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:26764 ! steroid hormone
relationship: has_primary_input CHEBI:26764 ! steroid hormone

[Term]
id: GO:0048546
name: digestive tract morphogenesis
namespace: biological_process
alt_id: GO:0048547
def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]
synonym: "alimentary canal morphogenesis" EXACT []
synonym: "digestive tube morphogenesis" EXACT []
synonym: "gastrointestinal tract morphogenesis" EXACT []
synonym: "gut morphogenesis" BROAD [GOC:dph]
synonym: "intestinal morphogenesis" NARROW []
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001555 ! digestive tract
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_morphogenesis_of UBERON:0001555 ! digestive tract

[Term]
id: GO:0048562
name: embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0048565
name: digestive tract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]
synonym: "gut development" BROAD [GOC:dph]
synonym: "intestinal development" NARROW []
synonym: "intestine development" NARROW []
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001555 ! digestive tract
relationship: part_of GO:0055123 ! digestive system development
relationship: results_in_development_of UBERON:0001555 ! digestive tract

[Term]
id: GO:0048568
name: embryonic organ development
namespace: biological_process
def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]
synonym: "embryonic organogenesis" EXACT []
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: part_of GO:0009790 ! embryo development
intersection_of: results_in_development_of UBERON:0000062 ! organ
relationship: part_of GO:0009790 ! embryo development
relationship: results_in_development_of UBERON:0000062 ! organ

[Term]
id: GO:0048570
name: notochord morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid]
is_a: GO:0048562 ! embryonic organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002328 ! notochord
relationship: part_of GO:0030903 ! notochord development
relationship: results_in_morphogenesis_of UBERON:0002328 ! notochord

[Term]
id: GO:0048580
name: regulation of post-embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009791 ! post-embryonic development
relationship: regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048581
name: negative regulation of post-embryonic development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "down regulation of post-embryonic development" EXACT []
synonym: "down-regulation of post-embryonic development" EXACT []
synonym: "downregulation of post-embryonic development" EXACT []
synonym: "inhibition of post-embryonic development" NARROW []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009791 ! post-embryonic development
relationship: negatively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048582
name: positive regulation of post-embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid]
synonym: "activation of post-embryonic development" NARROW []
synonym: "stimulation of post-embryonic development" NARROW []
synonym: "up regulation of post-embryonic development" EXACT []
synonym: "up-regulation of post-embryonic development" EXACT []
synonym: "upregulation of post-embryonic development" EXACT []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009791 ! post-embryonic development
relationship: positively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050896 ! response to stimulus
relationship: regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050896 ! response to stimulus
relationship: positively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050896 ! response to stimulus
relationship: negatively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
subset: gocheck_do_not_annotate
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048468 ! cell development
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0048589
name: developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0040007 ! growth
intersection_of: GO:0040007 ! growth
intersection_of: part_of GO:0032502 ! developmental process
relationship: part_of GO:0032502 ! developmental process

[Term]
id: GO:0048592
name: eye morphogenesis
namespace: biological_process
alt_id: GO:0048748
def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0090596 ! sensory organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000970 ! eye
relationship: part_of GO:0001654 ! eye development
relationship: results_in_morphogenesis_of UBERON:0000970 ! eye

[Term]
id: GO:0048593
name: camera-type eye morphogenesis
namespace: biological_process
alt_id: GO:0048594
alt_id: GO:0048595
def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu]
synonym: "camera-style eye morphogenesis" EXACT [GOC:dph]
is_a: GO:0048592 ! eye morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000019 ! camera-type eye
relationship: part_of GO:0043010 ! camera-type eye development
relationship: results_in_morphogenesis_of UBERON:0000019 ! camera-type eye

[Term]
id: GO:0048596
name: embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic eye morphogenesis" BROAD []
is_a: GO:0048048 ! embryonic eye morphogenesis
relationship: part_of GO:0031076 ! embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048598
name: embryonic morphogenesis
namespace: biological_process
alt_id: GO:0048828
def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]
synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009790 ! embryo development

[Term]
id: GO:0048599
name: oocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
is_a: GO:0007281 ! germ cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000023 ! oocyte
relationship: part_of GO:0009994 ! oocyte differentiation
relationship: results_in_development_of CL:0000023 ! oocyte

[Term]
id: GO:0048601
name: oocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
synonym: "oocyte morphogenesis during differentiation" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0003006 ! developmental process involved in reproduction
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of CL:0000023 ! oocyte
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0048599 ! oocyte development
relationship: results_in_morphogenesis_of CL:0000023 ! oocyte

[Term]
id: GO:0048608
name: reproductive structure development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061458 ! reproductive system development
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23445" xsd:anyURI

[Term]
id: GO:0048609
name: multicellular organismal reproductive process
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]
synonym: "organismal reproductive process" BROAD []
synonym: "reproductive process in a multicellular organism" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0048627
name: myoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000056 ! myoblast
relationship: part_of GO:0045445 ! myoblast differentiation
relationship: results_in_development_of CL:0000056 ! myoblast

[Term]
id: GO:0048628
name: myoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048469 ! cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000056 ! myoblast
relationship: part_of GO:0048627 ! myoblast development
relationship: results_in_maturation_of CL:0000056 ! myoblast

[Term]
id: GO:0048630
name: skeletal muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0001134 ! skeletal muscle tissue
relationship: part_of GO:0007519 ! skeletal muscle tissue development
relationship: results_in_growth_of UBERON:0001134 ! skeletal muscle tissue

[Term]
id: GO:0048631
name: regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048630 ! skeletal muscle tissue growth
relationship: regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048632
name: negative regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "down regulation of skeletal muscle growth" EXACT []
synonym: "down-regulation of skeletal muscle growth" EXACT []
synonym: "downregulation of skeletal muscle growth" EXACT []
synonym: "inhibition of skeletal muscle growth" NARROW []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048640 ! negative regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048630 ! skeletal muscle tissue growth
relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048633
name: positive regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "activation of skeletal muscle growth" NARROW []
synonym: "stimulation of skeletal muscle growth" NARROW []
synonym: "up regulation of skeletal muscle growth" EXACT []
synonym: "up-regulation of skeletal muscle growth" EXACT []
synonym: "upregulation of skeletal muscle growth" EXACT []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048630 ! skeletal muscle tissue growth
relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048634
name: regulation of muscle organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007517 ! muscle organ development
relationship: regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048635
name: negative regulation of muscle organ development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
synonym: "down regulation of muscle development" EXACT []
synonym: "down-regulation of muscle development" EXACT []
synonym: "downregulation of muscle development" EXACT []
synonym: "inhibition of muscle development" NARROW []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007517 ! muscle organ development
relationship: negatively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048636
name: positive regulation of muscle organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
synonym: "activation of muscle development" NARROW []
synonym: "stimulation of muscle development" NARROW []
synonym: "up regulation of muscle development" EXACT []
synonym: "up-regulation of muscle development" EXACT []
synonym: "upregulation of muscle development" EXACT []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007517 ! muscle organ development
relationship: positively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048638
name: regulation of developmental growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048589 ! developmental growth
relationship: regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048639
name: positive regulation of developmental growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators]
synonym: "activation of developmental growth" NARROW []
synonym: "stimulation of developmental growth" NARROW []
synonym: "up regulation of developmental growth" EXACT []
synonym: "up-regulation of developmental growth" EXACT []
synonym: "upregulation of developmental growth" EXACT []
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051094 ! positive regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048589 ! developmental growth
relationship: positively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048640
name: negative regulation of developmental growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
synonym: "down regulation of developmental growth" EXACT []
synonym: "down-regulation of developmental growth" EXACT []
synonym: "downregulation of developmental growth" EXACT []
synonym: "inhibition of developmental growth" NARROW []
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051093 ! negative regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048589 ! developmental growth
relationship: negatively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048641
name: regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007519 ! skeletal muscle tissue development
relationship: regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048642
name: negative regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
synonym: "down regulation of skeletal muscle development" EXACT []
synonym: "down-regulation of skeletal muscle development" EXACT []
synonym: "downregulation of skeletal muscle development" EXACT []
synonym: "inhibition of skeletal muscle development" NARROW []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007519 ! skeletal muscle tissue development
relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048643
name: positive regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators]
synonym: "activation of skeletal muscle development" NARROW []
synonym: "stimulation of skeletal muscle development" NARROW []
synonym: "up regulation of skeletal muscle development" EXACT []
synonym: "up-regulation of skeletal muscle development" EXACT []
synonym: "upregulation of skeletal muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007519 ! skeletal muscle tissue development
relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048644
name: muscle organ morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001630 ! muscle organ
relationship: part_of GO:0007517 ! muscle organ development
relationship: results_in_morphogenesis_of UBERON:0001630 ! muscle organ

[Term]
id: GO:0048645
name: animal organ formation
namespace: biological_process
def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid]
synonym: "animal organ primordium initiation" NARROW []
synonym: "initiation of an animal organ primordium" NARROW []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003103 ! compound organ
relationship: part_of GO:0009887 ! animal organ morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003103 ! compound organ

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
subset: goslim_chembl
synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048659
name: smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698]
synonym: "SMC proliferation" EXACT []
is_a: GO:0033002 ! muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000192 ! smooth muscle cell
relationship: acts_on_population_of CL:0000192 ! smooth muscle cell

[Term]
id: GO:0048660
name: regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "regulation of SMC proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048659 ! smooth muscle cell proliferation
relationship: regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048661
name: positive regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "activation of smooth muscle cell proliferation" NARROW []
synonym: "positive regulation of SMC proliferation" EXACT []
synonym: "stimulation of smooth muscle cell proliferation" NARROW []
synonym: "up regulation of smooth muscle cell proliferation" EXACT []
synonym: "up-regulation of smooth muscle cell proliferation" EXACT []
synonym: "upregulation of smooth muscle cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048659 ! smooth muscle cell proliferation
relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048662
name: negative regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "down regulation of smooth muscle cell proliferation" EXACT []
synonym: "down-regulation of smooth muscle cell proliferation" EXACT []
synonym: "downregulation of smooth muscle cell proliferation" EXACT []
synonym: "inhibition of smooth muscle cell proliferation" NARROW []
synonym: "negative regulation of SMC proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048659 ! smooth muscle cell proliferation
relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048666
name: neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000540 ! neuron
relationship: part_of GO:0030182 ! neuron differentiation
relationship: results_in_development_of CL:0000540 ! neuron

[Term]
id: GO:0048667
name: cell morphogenesis involved in neuron differentiation
namespace: biological_process
def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0030182 ! neuron differentiation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0048699
name: generation of neurons
namespace: biological_process
def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
synonym: "neuron generation" EXACT []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0048705
name: skeletal system morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb]
synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001434 ! skeletal system
relationship: part_of GO:0001501 ! skeletal system development
relationship: results_in_morphogenesis_of UBERON:0001434 ! skeletal system

[Term]
id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000479 ! tissue
relationship: part_of GO:0009888 ! tissue development
relationship: results_in_morphogenesis_of UBERON:0000479 ! tissue

[Term]
id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]
synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007376 ! outer epithelium
relationship: part_of GO:0008544 ! epidermis development
relationship: results_in_morphogenesis_of UBERON:0007376 ! outer epithelium

[Term]
id: GO:0048731
name: system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]
subset: goslim_mouse
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000467 ! anatomical system
relationship: part_of GO:0007275 ! multicellular organism development
relationship: results_in_development_of UBERON:0000467 ! anatomical system

[Term]
id: GO:0048732
name: gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002530 ! gland
relationship: results_in_development_of UBERON:0002530 ! gland

[Term]
id: GO:0048736
name: appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000026 ! appendage
relationship: part_of GO:0007275 ! multicellular organism development
relationship: results_in_development_of UBERON:0000026 ! appendage

[Term]
id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
synonym: "heart muscle development" EXACT []
is_a: GO:0014706 ! striated muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001133 ! cardiac muscle tissue
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "skeletal muscle fibre development" EXACT []
synonym: "skeletal myofiber development" EXACT []
synonym: "skeletal myofibre development" EXACT []
is_a: GO:0014904 ! myotube cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0008002 ! skeletal muscle fiber
relationship: part_of GO:0007519 ! skeletal muscle tissue development
relationship: results_in_development_of CL:0008002 ! skeletal muscle fiber

[Term]
id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]
synonym: "regulation of skeletal muscle fibre development" EXACT []
synonym: "regulation of skeletal myofiber development" EXACT []
synonym: "regulation of skeletal myofibre development" EXACT []
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048741 ! skeletal muscle fiber development
relationship: regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "activation of skeletal muscle fiber development" NARROW []
synonym: "positive regulation of skeletal muscle fibre development" EXACT []
synonym: "positive regulation of skeletal myofiber development" EXACT []
synonym: "positive regulation of skeletal myofibre development" EXACT []
synonym: "stimulation of skeletal muscle fiber development" NARROW []
synonym: "up regulation of skeletal muscle fiber development" EXACT []
synonym: "up-regulation of skeletal muscle fiber development" EXACT []
synonym: "upregulation of skeletal muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048741 ! skeletal muscle fiber development
relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]
synonym: "down regulation of skeletal muscle fiber development" EXACT []
synonym: "down-regulation of skeletal muscle fiber development" EXACT []
synonym: "downregulation of skeletal muscle fiber development" EXACT []
synonym: "inhibition of skeletal muscle fiber development" NARROW []
synonym: "negative regulation of skeletal muscle fibre development" EXACT []
synonym: "negative regulation of skeletal myofiber development" EXACT []
synonym: "negative regulation of skeletal myofibre development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048741 ! skeletal muscle fiber development
relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]
is_a: GO:0060537 ! muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001135 ! smooth muscle tissue
relationship: results_in_development_of UBERON:0001135 ! smooth muscle tissue

[Term]
id: GO:0048749
name: compound eye development
namespace: biological_process
alt_id: GO:0007456
def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]
synonym: "insect-type retina development" EXACT [PMID:11735386]
is_a: GO:0001654 ! eye development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000018 ! compound eye
relationship: results_in_development_of UBERON:0000018 ! compound eye

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT []
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0048770 ! pigment granule
relationship: part_of GO:0033059 ! cellular pigmentation
relationship: results_in_organization_of GO:0048770 ! pigment granule

[Term]
id: GO:0048754
name: branching morphogenesis of an epithelial tube
namespace: biological_process
def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]
synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: results_in_morphogenesis_of UBERON:0000025 ! tube
relationship: part_of GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid]
is_a: GO:0001763 ! morphogenesis of a branching structure
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: results_in_morphogenesis_of UBERON:0001021 ! nerve
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_morphogenesis_of UBERON:0001021 ! nerve

[Term]
id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0008019 ! mesenchymal cell
relationship: part_of GO:0060485 ! mesenchyme development
relationship: results_in_acquisition_of_features_of CL:0008019 ! mesenchymal cell

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0048793
name: pronephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]
synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0001822 ! kidney development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002120 ! pronephros
relationship: results_in_development_of UBERON:0002120 ! pronephros

[Term]
id: GO:0048799
name: animal organ maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0000062 ! organ
relationship: part_of GO:0048513 ! animal organ development
relationship: results_in_maturation_of UBERON:0000062 ! organ

[Term]
id: GO:0048806
name: genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]
synonym: "genital development" EXACT []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048808
name: male genitalia morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888]
synonym: "male genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0090598 ! male anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000079 ! male reproductive system
relationship: part_of GO:0030539 ! male genitalia development
relationship: results_in_morphogenesis_of UBERON:0000079 ! male reproductive system

[Term]
id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of GO:0043005 ! neuron projection
relationship: part_of GO:0031175 ! neuron projection development
relationship: results_in_morphogenesis_of GO:0043005 ! neuron projection

[Term]
id: GO:0048821
name: erythrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol]
synonym: "RBC development" EXACT [CL:0000232]
synonym: "red blood cell development" EXACT [CL:0000232]
is_a: GO:0061515 ! myeloid cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000232 ! erythrocyte
relationship: part_of GO:0030218 ! erythrocyte differentiation
relationship: results_in_development_of CL:0000232 ! erythrocyte

[Term]
id: GO:0048822
name: enucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "enucleate RBC development" EXACT [CL:0000232]
synonym: "enucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000595 ! enucleate erythrocyte
relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation
relationship: results_in_development_of CL:0000595 ! enucleate erythrocyte

[Term]
id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "nucleate RBC development" EXACT [CL:0000232]
synonym: "nucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000562 ! nucleate erythrocyte
relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation
relationship: results_in_development_of CL:0000562 ! nucleate erythrocyte

[Term]
id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]
synonym: "arterial morphogenesis" EXACT []
synonym: "arteriogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001637 ! artery
relationship: part_of GO:0060840 ! artery development
relationship: results_in_morphogenesis_of UBERON:0001637 ! artery

[Term]
id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]
synonym: "vein morphogenesis" BROAD []
synonym: "venous morphogenesis" EXACT []
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001638 ! vein
relationship: part_of GO:0060841 ! venous blood vessel development
relationship: results_in_morphogenesis_of UBERON:0001638 ! vein

[Term]
id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000955 ! brain
relationship: part_of GO:0007420 ! brain development
relationship: results_in_morphogenesis_of UBERON:0000955 ! brain

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
subset: gocheck_do_not_annotate
subset: goslim_chembl
subset: goslim_generic
subset: goslim_plant
synonym: "development of an anatomical structure" EXACT []
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of UBERON:0000061 ! anatomical structure
relationship: results_in_development_of UBERON:0000061 ! anatomical structure
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI

[Term]
id: GO:0048857
name: neural nucleus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000125 ! neural nucleus
relationship: results_in_development_of UBERON:0000125 ! neural nucleus

[Term]
id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021]
is_a: GO:0030030 ! cell projection organization
is_a: GO:0032989 ! cellular anatomical entity morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of GO:0042995 ! cell projection
relationship: part_of GO:0000902 ! cell morphogenesis
relationship: results_in_morphogenesis_of GO:0042995 ! cell projection

[Term]
id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0007651 ! anatomical junction
relationship: results_in_formation_of_anatomical_entity UBERON:0007651 ! anatomical junction

[Term]
id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
xref: Wikipedia:Stem_cell_differentiation
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000034 ! stem cell
relationship: results_in_acquisition_of_features_of CL:0000034 ! stem cell
property_value: RO:0002161 NCBITaxon:4751

[Term]
id: GO:0048864
name: stem cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000034 ! stem cell
relationship: part_of GO:0048863 ! stem cell differentiation
relationship: results_in_development_of CL:0000034 ! stem cell

[Term]
id: GO:0048869
name: cellular developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]
is_a: GO:0009987 ! cellular process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048870
name: cell motility
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_prokaryote
synonym: "cell locomotion" EXACT []
synonym: "cell movement" RELATED []
synonym: "movement of a cell" EXACT []
is_a: GO:0009987 ! cellular process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI

[Term]
id: GO:0048871
name: multicellular organismal-level homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]
synonym: "cell population homeostasis" EXACT []
synonym: "homeostasis of cell number" EXACT [GOC:dph]
is_a: GO:0048871 ! multicellular organismal-level homeostasis
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI

[Term]
id: GO:0048880
name: sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001032 ! sensory system
relationship: results_in_development_of UBERON:0001032 ! sensory system

[Term]
id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:2000032 ! peripheral nervous system neuron
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: results_in_acquisition_of_features_of CL:2000032 ! peripheral nervous system neuron

[Term]
id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:2000032 ! peripheral nervous system neuron
relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation
relationship: results_in_development_of CL:2000032 ! peripheral nervous system neuron

[Term]
id: GO:0050000
name: chromosome localization
namespace: biological_process
def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "chromosome localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of chromosome localization" EXACT []
synonym: "establishment and maintenance of chromosome position" EXACT []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0005694 ! chromosome
relationship: has_primary_input GO:0005694 ! chromosome

[Term]
id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:33567 ! catecholamine

[Term]
id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050432 ! catecholamine secretion
relationship: regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
is_a: GO:0015931 ! nucleobase-containing compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33696 ! nucleic acid
relationship: has_primary_input CHEBI:33696 ! nucleic acid

[Term]
id: GO:0050658
name: RNA transport
namespace: biological_process
def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
is_a: GO:0051236 ! establishment of RNA localization
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid
relationship: has_primary_input CHEBI:33697 ! ribonucleic acid

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai]
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046651 ! lymphocyte proliferation
relationship: regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050671
name: positive regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "activation of lymphocyte proliferation" NARROW []
synonym: "stimulation of lymphocyte proliferation" NARROW []
synonym: "up regulation of lymphocyte proliferation" EXACT []
synonym: "up-regulation of lymphocyte proliferation" EXACT []
synonym: "upregulation of lymphocyte proliferation" EXACT []
is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046651 ! lymphocyte proliferation
relationship: positively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "down regulation of lymphocyte proliferation" EXACT []
synonym: "down-regulation of lymphocyte proliferation" EXACT []
synonym: "downregulation of lymphocyte proliferation" EXACT []
synonym: "inhibition of lymphocyte proliferation" NARROW []
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046651 ! lymphocyte proliferation
relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000066 ! epithelial cell
relationship: acts_on_population_of CL:0000066 ! epithelial cell

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050673 ! epithelial cell proliferation
relationship: regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "activation of epithelial cell proliferation" NARROW []
synonym: "stimulation of epithelial cell proliferation" NARROW []
synonym: "up regulation of epithelial cell proliferation" EXACT []
synonym: "up-regulation of epithelial cell proliferation" EXACT []
synonym: "upregulation of epithelial cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050673 ! epithelial cell proliferation
relationship: positively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "down regulation of epithelial cell proliferation" EXACT []
synonym: "down-regulation of epithelial cell proliferation" EXACT []
synonym: "downregulation of epithelial cell proliferation" EXACT []
synonym: "inhibition of epithelial cell proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050673 ! epithelial cell proliferation
relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009306 ! protein secretion
relationship: regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "down regulation of protein secretion" EXACT []
synonym: "down-regulation of protein secretion" EXACT []
synonym: "downregulation of protein secretion" EXACT []
synonym: "inhibition of protein secretion" NARROW []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:1903531 ! negative regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009306 ! protein secretion
relationship: negatively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]
synonym: "activation of protein secretion" NARROW []
synonym: "stimulation of protein secretion" NARROW []
synonym: "up regulation of protein secretion" EXACT []
synonym: "up-regulation of protein secretion" EXACT []
synonym: "upregulation of protein secretion" EXACT []
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:1903532 ! positive regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009306 ! protein secretion
relationship: positively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006954 ! inflammatory response
relationship: regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
alt_id: GO:0030236
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "anti-inflammatory response" EXACT []
synonym: "down regulation of inflammatory response" EXACT []
synonym: "down-regulation of inflammatory response" EXACT []
synonym: "downregulation of inflammatory response" EXACT []
synonym: "inhibition of inflammatory response" NARROW []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006954 ! inflammatory response
relationship: negatively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "activation of inflammatory response" NARROW []
synonym: "stimulation of inflammatory response" NARROW []
synonym: "up regulation of inflammatory response" EXACT []
synonym: "up-regulation of inflammatory response" EXACT []
synonym: "upregulation of inflammatory response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006954 ! inflammatory response
relationship: positively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]
is_a: GO:0030100 ! regulation of endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006909 ! phagocytosis
relationship: regulates GO:0006909 ! phagocytosis
property_value: RO:0002161 NCBITaxon:147537

[Term]
id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "down regulation of phagocytosis" EXACT []
synonym: "down-regulation of phagocytosis" EXACT []
synonym: "downregulation of phagocytosis" EXACT []
synonym: "inhibition of phagocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006909 ! phagocytosis
relationship: negatively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050766
name: positive regulation of phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "activation of phagocytosis" NARROW []
synonym: "stimulation of phagocytosis" NARROW []
synonym: "up regulation of phagocytosis" EXACT []
synonym: "up-regulation of phagocytosis" EXACT []
synonym: "upregulation of phagocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006909 ! phagocytosis
relationship: positively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022008 ! neurogenesis
relationship: regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "down regulation of neurogenesis" EXACT []
synonym: "down-regulation of neurogenesis" EXACT []
synonym: "downregulation of neurogenesis" EXACT []
synonym: "inhibition of neurogenesis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051961 ! negative regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022008 ! neurogenesis
relationship: negatively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]
synonym: "activation of neurogenesis" NARROW []
synonym: "stimulation of neurogenesis" NARROW []
synonym: "up regulation of neurogenesis" EXACT []
synonym: "up-regulation of neurogenesis" EXACT []
synonym: "upregulation of neurogenesis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
is_a: GO:0051962 ! positive regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022008 ! neurogenesis
relationship: positively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050776
name: regulation of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006955 ! immune response
relationship: regulates GO:0006955 ! immune response

[Term]
id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "down regulation of immune response" EXACT []
synonym: "down-regulation of immune response" EXACT []
synonym: "downregulation of immune response" EXACT []
synonym: "inhibition of immune response" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006955 ! immune response
relationship: negatively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "stimulation of immune response" NARROW []
synonym: "up regulation of immune response" EXACT []
synonym: "up-regulation of immune response" EXACT []
synonym: "upregulation of immune response" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006955 ! immune response
relationship: positively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: gocheck_do_not_annotate
subset: goslim_candida
subset: goslim_pir
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008150 ! biological process
relationship: regulates GO:0008150 ! biological process

[Term]
id: GO:0050790
name: regulation of catalytic activity
namespace: biological_process
alt_id: GO:0048552
def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_chembl
synonym: "regulation of enzyme activity" EXACT []
synonym: "regulation of metalloenzyme activity" NARROW []
is_a: GO:0065009 ! regulation of molecular function
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003824 ! catalytic activity
relationship: regulates GO:0003824 ! catalytic activity

[Term]
id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032502 ! developmental process
relationship: regulates GO:0032502 ! developmental process

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gocheck_do_not_annotate
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009987 ! cellular process
relationship: regulates GO:0009987 ! cellular process

[Term]
id: GO:0050795
name: regulation of behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]
synonym: "regulation of behaviour" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007610 ! behavior
relationship: regulates GO:0007610 ! behavior

[Term]
id: GO:0050796
name: regulation of insulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030073 ! insulin secretion
relationship: regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0050803
name: regulation of synapse structure or activity
namespace: biological_process
def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa

[Term]
id: GO:0050804
name: modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]
subset: goslim_synapse
synonym: "modulation of synaptic transmission" BROAD []
synonym: "regulation of chemical synaptic transmission" EXACT []
synonym: "regulation of synaptic transmission" EXACT []
is_a: GO:0099177 ! regulation of trans-synaptic signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007268 ! chemical synaptic transmission
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "down regulation of synaptic transmission" EXACT []
synonym: "down-regulation of synaptic transmission" EXACT []
synonym: "downregulation of synaptic transmission" EXACT []
synonym: "inhibition of synaptic transmission" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007268 ! chemical synaptic transmission
relationship: negatively_regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "activation of synaptic transmission" NARROW []
synonym: "stimulation of synaptic transmission" NARROW []
synonym: "up regulation of synaptic transmission" EXACT []
synonym: "up-regulation of synaptic transmission" EXACT []
synonym: "upregulation of synaptic transmission" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007268 ! chemical synaptic transmission
relationship: positively_regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of synapse organisation" EXACT [GOC:mah]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050808 ! synapse organization
relationship: part_of GO:0050803 ! regulation of synapse structure or activity
relationship: regulates GO:0050808 ! synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]
subset: goslim_drosophila
subset: goslim_synapse
synonym: "synapse development" RELATED [GOC:aruk]
synonym: "synapse morphogenesis" RELATED [GOC:BHF]
synonym: "synapse organisation" EXACT []
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_organization_of GO:0045202 ! synapse
relationship: results_in_organization_of GO:0045202 ! synapse

[Term]
id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]
synonym: "regulation of steroid anabolism" EXACT []
synonym: "regulation of steroid biosynthesis" EXACT []
synonym: "regulation of steroid formation" EXACT []
synonym: "regulation of steroid synthesis" EXACT []
synonym: "regulation of steroidogenesis" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006694 ! steroid biosynthetic process
relationship: regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0050832
name: defense response to fungus
namespace: biological_process
alt_id: GO:0009623
alt_id: GO:0009817
alt_id: GO:0042831
def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to fungi" EXACT []
synonym: "defence response to fungus" EXACT []
synonym: "defense response to fungi" EXACT []
synonym: "defense response to fungus, incompatible interaction" NARROW []
synonym: "resistance response to pathogenic fungi" NARROW []
synonym: "resistance response to pathogenic fungus" NARROW []
synonym: "response to parasitic fungi" NARROW []
synonym: "response to parasitic fungus" NARROW []
is_a: GO:0009620 ! response to fungus
is_a: GO:0098542 ! defense response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: has_primary_input NCBITaxon:4751 ! Fungi

[Term]
id: GO:0050863
name: regulation of T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "regulation of T lymphocyte activation" EXACT []
synonym: "regulation of T-cell activation" EXACT []
synonym: "regulation of T-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042110 ! T cell activation
relationship: regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001775 ! cell activation
relationship: regulates GO:0001775 ! cell activation

[Term]
id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai]
synonym: "down regulation of cell activation" EXACT []
synonym: "down-regulation of cell activation" EXACT []
synonym: "downregulation of cell activation" EXACT []
synonym: "inhibition of cell activation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001775 ! cell activation
relationship: negatively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai]
synonym: "activation of cell activation" NARROW []
synonym: "stimulation of cell activation" NARROW []
synonym: "up regulation of cell activation" EXACT []
synonym: "up-regulation of cell activation" EXACT []
synonym: "upregulation of cell activation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001775 ! cell activation
relationship: positively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "down regulation of T cell activation" EXACT []
synonym: "down-regulation of T cell activation" EXACT []
synonym: "downregulation of T cell activation" EXACT []
synonym: "inhibition of T cell activation" NARROW []
synonym: "negative regulation of T lymphocyte activation" EXACT []
synonym: "negative regulation of T-cell activation" EXACT []
synonym: "negative regulation of T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042110 ! T cell activation
relationship: negatively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "activation of T cell activation" NARROW []
synonym: "positive regulation of T lymphocyte activation" EXACT []
synonym: "positive regulation of T-cell activation" EXACT []
synonym: "positive regulation of T-lymphocyte activation" EXACT []
synonym: "stimulation of T cell activation" NARROW []
synonym: "up regulation of T cell activation" EXACT []
synonym: "up-regulation of T cell activation" EXACT []
synonym: "upregulation of T cell activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042110 ! T cell activation
relationship: positively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050877
name: nervous system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_agr
subset: goslim_chembl
subset: goslim_flybase_ribbon
subset: goslim_generic
subset: goslim_pir
synonym: "neurological system process" EXACT []
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0003008 ! system process
intersection_of: GO:0003008 ! system process
intersection_of: has_participant UBERON:0001016 ! nervous system
relationship: has_participant UBERON:0001016 ! nervous system
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13824" xsd:anyURI

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]
is_a: GO:0050879 ! multicellular organismal movement
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]
subset: goslim_generic
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050890
name: cognition
namespace: biological_process
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]
subset: goslim_drosophila
xref: Wikipedia:Cognition
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
subset: goslim_prokaryote
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological process

[Term]
id: GO:0050900
name: leukocyte migration
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration" EXACT []
synonym: "immune cell trafficking" EXACT []
synonym: "leucocyte migration" EXACT []
synonym: "leucocyte trafficking" EXACT []
synonym: "leukocyte trafficking" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: results_in_movement_of CL:0000738 ! leukocyte

[Term]
id: GO:0050905
name: neuromuscular process
namespace: biological_process
def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
synonym: "neuromotor process" EXACT []
synonym: "neuromuscular physiological process" EXACT []
is_a: GO:0050877 ! nervous system process

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]
synonym: "sensory detection of stimulus" EXACT []
synonym: "sensory perception, sensory transduction of stimulus" EXACT []
synonym: "sensory perception, stimulus detection" EXACT []
synonym: "sensory transduction" EXACT []
xref: Wikipedia:Transduction_(physiology)
is_a: GO:0051606 ! detection of stimulus
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "sensory detection of light during visual perception" EXACT []
synonym: "sensory detection of light stimulus during visual perception" EXACT []
synonym: "sensory transduction of light during visual perception" EXACT []
synonym: "sensory transduction of light stimulus during visual perception" EXACT []
synonym: "visual perception, detection of light stimulus" EXACT []
synonym: "visual perception, sensory transduction during perception of light" EXACT []
synonym: "visual perception, sensory transduction of light stimulus" EXACT []
is_a: GO:0009584 ! detection of visible light
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: part_of GO:0007601 ! visual perception
relationship: part_of GO:0007601 ! visual perception

[Term]
id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
alt_id: GO:0043357
alt_id: GO:0043358
def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]
comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
synonym: "chromatophore differentiation" EXACT []
synonym: "pigmented cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000147 ! pigment cell
relationship: part_of GO:0048066 ! developmental pigmentation
relationship: results_in_acquisition_of_features_of CL:0000147 ! pigment cell

[Term]
id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050931 ! pigment cell differentiation
relationship: regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "down regulation of pigment cell differentiation" EXACT []
synonym: "down-regulation of pigment cell differentiation" EXACT []
synonym: "downregulation of pigment cell differentiation" EXACT []
synonym: "inhibition of pigment cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048086 ! negative regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050931 ! pigment cell differentiation
relationship: negatively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "activation of pigment cell differentiation" NARROW []
synonym: "stimulation of pigment cell differentiation" NARROW []
synonym: "up regulation of pigment cell differentiation" EXACT []
synonym: "up-regulation of pigment cell differentiation" EXACT []
synonym: "upregulation of pigment cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048087 ! positive regulation of developmental pigmentation
is_a: GO:0050932 ! regulation of pigment cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050931 ! pigment cell differentiation
relationship: positively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050952
name: sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanosensory perception" EXACT []
synonym: "perception of mechanical stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050956
name: electroception
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception]
synonym: "electroception sense" EXACT []
synonym: "electroceptive sense" EXACT []
xref: Wikipedia:Electroreception
is_a: GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]
synonym: "sensory detection of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of light stimulus" EXACT []
synonym: "sensory perception, sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus during sensory perception" EXACT []
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0009583 ! detection of light stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0050963
name: detection of electrical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]
synonym: "sensory detection of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050981 ! detection of electrical stimulus
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0007600 ! sensory perception
relationship: part_of GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050964
name: detection of electrical stimulus involved in electroception
namespace: biological_process
def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb]
synonym: "electroception, detection of electrical stimulus" EXACT []
synonym: "electroception, sensory detection of electrical stimulus" EXACT []
synonym: "electroception, sensory transduction" EXACT []
synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during electroception" RELATED []
synonym: "sensory transduction of electrical stimulus during electroception" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0050956 ! electroception
relationship: part_of GO:0050956 ! electroception

[Term]
id: GO:0050967
name: detection of electrical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb]
synonym: "perception of pain, detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during perception of pain" RELATED []
synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
intersection_of: GO:0050981 ! detection of electrical stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]
synonym: "chemical nociception" RELATED [GOC:pr]
synonym: "perception of pain, detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
synonym: "perception of touch" EXACT []
synonym: "tactile sense" EXACT []
synonym: "taction" EXACT []
synonym: "tactition" EXACT []
xref: Wikipedia:Touch
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050981
name: detection of electrical stimulus
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "regulation of lipid breakdown" EXACT []
synonym: "regulation of lipid catabolism" EXACT []
synonym: "regulation of lipid degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016042 ! lipid catabolic process
relationship: regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "down regulation of lipid catabolic process" EXACT []
synonym: "down-regulation of lipid catabolic process" EXACT []
synonym: "downregulation of lipid catabolic process" EXACT []
synonym: "inhibition of lipid catabolic process" NARROW []
synonym: "negative regulation of lipid breakdown" EXACT []
synonym: "negative regulation of lipid catabolism" EXACT []
synonym: "negative regulation of lipid degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016042 ! lipid catabolic process
relationship: negatively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "activation of lipid catabolic process" NARROW []
synonym: "positive regulation of lipid breakdown" EXACT []
synonym: "positive regulation of lipid catabolism" EXACT []
synonym: "positive regulation of lipid degradation" EXACT []
synonym: "stimulation of lipid catabolic process" NARROW []
synonym: "up regulation of lipid catabolic process" EXACT []
synonym: "up-regulation of lipid catabolic process" EXACT []
synonym: "upregulation of lipid catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016042 ! lipid catabolic process
relationship: positively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
alt_id: GO:0045011
def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
synonym: "actin bundling activity" RELATED []
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061572 ! actin filament bundle organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0032432 ! actin filament bundle
relationship: results_in_assembly_of GO:0032432 ! actin filament bundle

[Term]
id: GO:0051027
name: DNA transport
namespace: biological_process
def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
relationship: has_primary_input CHEBI:16991 ! deoxyribonucleic acid

[Term]
id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]
is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:33696 ! nucleic acid
relationship: has_primary_input CHEBI:33696 ! nucleic acid
relationship: part_of GO:0050657 ! nucleic acid transport

[Term]
id: GO:0051033
name: RNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol"
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid
relationship: has_primary_input CHEBI:33697 ! ribonucleic acid
relationship: part_of GO:0050658 ! RNA transport

[Term]
id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
relationship: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
relationship: part_of GO:0051027 ! DNA transport

[Term]
id: GO:0051046
name: regulation of secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046903 ! secretion
relationship: regulates GO:0046903 ! secretion

[Term]
id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "activation of secretion" NARROW []
synonym: "stimulation of secretion" NARROW []
synonym: "up regulation of secretion" EXACT []
synonym: "up-regulation of secretion" EXACT []
synonym: "upregulation of secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046903 ! secretion
relationship: positively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]
synonym: "down regulation of secretion" EXACT []
synonym: "down-regulation of secretion" EXACT []
synonym: "downregulation of secretion" EXACT []
synonym: "inhibition of secretion" NARROW []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051051 ! negative regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046903 ! secretion
relationship: negatively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051049
name: regulation of transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_yeast
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006810 ! transport
relationship: regulates GO:0006810 ! transport

[Term]
id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of transport" NARROW []
synonym: "stimulation of transport" NARROW []
synonym: "up regulation of transport" EXACT []
synonym: "up-regulation of transport" EXACT []
synonym: "upregulation of transport" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006810 ! transport
relationship: positively_regulates GO:0006810 ! transport

[Term]
id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of transport" EXACT []
synonym: "down-regulation of transport" EXACT []
synonym: "downregulation of transport" EXACT []
synonym: "inhibition of transport" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006810 ! transport
relationship: negatively_regulates GO:0006810 ! transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: goslim_yeast
synonym: "regulation of DNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006259 ! DNA metabolic process
relationship: regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "down regulation of DNA metabolic process" EXACT []
synonym: "down-regulation of DNA metabolic process" EXACT []
synonym: "downregulation of DNA metabolic process" EXACT []
synonym: "inhibition of DNA metabolic process" NARROW []
synonym: "negative regulation of DNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process
relationship: negatively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
synonym: "activation of DNA metabolic process" NARROW []
synonym: "positive regulation of DNA metabolism" EXACT []
synonym: "stimulation of DNA metabolic process" NARROW []
synonym: "up regulation of DNA metabolic process" EXACT []
synonym: "up-regulation of DNA metabolic process" EXACT []
synonym: "upregulation of DNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006259 ! DNA metabolic process
relationship: positively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
synonym: "down regulation of lipid biosynthetic process" EXACT []
synonym: "down-regulation of lipid biosynthetic process" EXACT []
synonym: "downregulation of lipid biosynthetic process" EXACT []
synonym: "inhibition of lipid biosynthetic process" NARROW []
synonym: "negative regulation of lipid anabolism" EXACT []
synonym: "negative regulation of lipid biosynthesis" EXACT []
synonym: "negative regulation of lipid formation" EXACT []
synonym: "negative regulation of lipid synthesis" EXACT []
synonym: "negative regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008610 ! lipid biosynthetic process
relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0051078
name: meiotic nuclear membrane disassembly
namespace: biological_process
def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf]
synonym: "meiotic nuclear envelope breakdown" RELATED []
synonym: "meiotic nuclear envelope catabolism" RELATED []
synonym: "meiotic nuclear envelope degradation" RELATED []
synonym: "meiotic nuclear envelope disassembly" RELATED []
is_a: GO:0051081 ! nuclear membrane disassembly
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051080
name: meiosis II nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf]
synonym: "meiosis II nuclear envelope breakdown" RELATED []
synonym: "meiosis II nuclear envelope catabolism" RELATED []
synonym: "meiosis II nuclear envelope degradation" RELATED []
synonym: "meiosis II nuclear envelope disassembly" RELATED []
is_a: GO:0051078 ! meiotic nuclear membrane disassembly
intersection_of: GO:0051081 ! nuclear membrane disassembly
intersection_of: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051081
name: nuclear membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai]
synonym: "nuclear envelope breakdown" RELATED []
synonym: "nuclear envelope catabolism" RELATED []
synonym: "nuclear envelope degradation" RELATED []
synonym: "nuclear envelope disassembly" RELATED []
is_a: GO:0030397 ! membrane disassembly
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0031965 ! nuclear membrane
relationship: results_in_disassembly_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "down regulation of developmental process" EXACT []
synonym: "down-regulation of developmental process" EXACT []
synonym: "downregulation of developmental process" EXACT []
synonym: "inhibition of developmental process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032502 ! developmental process
relationship: negatively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
synonym: "activation of developmental process" NARROW []
synonym: "stimulation of developmental process" NARROW []
synonym: "up regulation of developmental process" EXACT []
synonym: "up-regulation of developmental process" EXACT []
synonym: "upregulation of developmental process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032502 ! developmental process
relationship: positively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051119
name: sugar transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "sugar/polyol channel activity" NARROW []
xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose"
xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol"
xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region"
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "regulation of cell organisation" RELATED [GOC:mah]
synonym: "regulation of cell organization" RELATED [GOC:mah]
synonym: "regulation of cellular component organisation" EXACT []
synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016043 ! cellular component organization
relationship: regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "down regulation of cell organization" EXACT []
synonym: "down-regulation of cell organization" EXACT []
synonym: "downregulation of cell organization" EXACT []
synonym: "inhibition of cell organization" NARROW []
synonym: "negative regulation of cell organisation" RELATED [GOC:mah]
synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016043 ! cellular component organization
relationship: negatively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "activation of cell organization" NARROW []
synonym: "positive regulation of cell organisation" EXACT []
synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell organization" NARROW []
synonym: "up regulation of cell organization" EXACT []
synonym: "up-regulation of cell organization" EXACT []
synonym: "upregulation of cell organization" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016043 ! cellular component organization
relationship: positively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]
synonym: "nonstriated muscle cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000192 ! smooth muscle cell
relationship: results_in_acquisition_of_features_of CL:0000192 ! smooth muscle cell

[Term]
id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]
synonym: "voluntary muscle cell differentiation" NARROW []
is_a: GO:0042692 ! muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000737 ! striated muscle cell
relationship: results_in_acquisition_of_features_of CL:0000737 ! striated muscle cell

[Term]
id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042692 ! muscle cell differentiation
relationship: regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "down regulation of muscle cell differentiation" EXACT []
synonym: "down-regulation of muscle cell differentiation" EXACT []
synonym: "downregulation of muscle cell differentiation" EXACT []
synonym: "inhibition of muscle cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042692 ! muscle cell differentiation
relationship: negatively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "activation of muscle cell differentiation" NARROW []
synonym: "stimulation of muscle cell differentiation" NARROW []
synonym: "up regulation of muscle cell differentiation" EXACT []
synonym: "up-regulation of muscle cell differentiation" EXACT []
synonym: "upregulation of muscle cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042692 ! muscle cell differentiation
relationship: positively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051145 ! smooth muscle cell differentiation
relationship: regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "down regulation of smooth muscle cell differentiation" EXACT []
synonym: "down-regulation of smooth muscle cell differentiation" EXACT []
synonym: "downregulation of smooth muscle cell differentiation" EXACT []
synonym: "inhibition of smooth muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051145 ! smooth muscle cell differentiation
relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "activation of smooth muscle cell differentiation" NARROW []
synonym: "stimulation of smooth muscle cell differentiation" NARROW []
synonym: "up regulation of smooth muscle cell differentiation" EXACT []
synonym: "up-regulation of smooth muscle cell differentiation" EXACT []
synonym: "upregulation of smooth muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051145 ! smooth muscle cell differentiation
relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051146 ! striated muscle cell differentiation
relationship: regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "down regulation of striated muscle cell differentiation" EXACT []
synonym: "down-regulation of striated muscle cell differentiation" EXACT []
synonym: "downregulation of striated muscle cell differentiation" EXACT []
synonym: "inhibition of striated muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051146 ! striated muscle cell differentiation
relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "activation of striated muscle cell differentiation" NARROW []
synonym: "stimulation of striated muscle cell differentiation" NARROW []
synonym: "up regulation of striated muscle cell differentiation" EXACT []
synonym: "up-regulation of striated muscle cell differentiation" EXACT []
synonym: "upregulation of striated muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051146 ! striated muscle cell differentiation
relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051169
name: nuclear transport
namespace: biological_process
def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai]
subset: goslim_yeast
synonym: "nucleus transport" EXACT []
xref: Wikipedia:Nuclear_transport
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
intersection_of: results_in_transport_to_from_or_in GO:0005634 ! nucleus
relationship: results_in_transport_to_from_or_in GO:0005634 ! nucleus

[Term]
id: GO:0051171
name: regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "regulation of nitrogen metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process
relationship: regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051172
name: negative regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "down regulation of nitrogen metabolic process" EXACT []
synonym: "down-regulation of nitrogen metabolic process" EXACT []
synonym: "downregulation of nitrogen metabolic process" EXACT []
synonym: "inhibition of nitrogen metabolic process" NARROW []
synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "negative regulation of nitrogen metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process
relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051173
name: positive regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "activation of nitrogen metabolic process" NARROW []
synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "positive regulation of nitrogen metabolism" EXACT []
synonym: "stimulation of nitrogen metabolic process" NARROW []
synonym: "up regulation of nitrogen metabolic process" EXACT []
synonym: "up-regulation of nitrogen metabolic process" EXACT []
synonym: "upregulation of nitrogen metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process
relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]
synonym: "regulation of phosphorus metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006793 ! phosphorus metabolic process
relationship: regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0051175
name: negative regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
synonym: "down regulation of sulfur metabolic process" EXACT []
synonym: "down-regulation of sulfur metabolic process" EXACT []
synonym: "downregulation of sulfur metabolic process" EXACT []
synonym: "inhibition of sulfur metabolic process" NARROW []
synonym: "negative regulation of sulfur metabolism" EXACT []
synonym: "negative regulation of sulphur metabolic process" EXACT []
synonym: "negative regulation of sulphur metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006790 ! sulfur compound metabolic process
relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051176
name: positive regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
synonym: "activation of sulfur metabolic process" NARROW []
synonym: "positive regulation of sulfur metabolism" EXACT []
synonym: "positive regulation of sulphur metabolic process" EXACT []
synonym: "positive regulation of sulphur metabolism" EXACT []
synonym: "stimulation of sulfur metabolic process" NARROW []
synonym: "up regulation of sulfur metabolic process" EXACT []
synonym: "up-regulation of sulfur metabolic process" EXACT []
synonym: "upregulation of sulfur metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006790 ! sulfur compound metabolic process
relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0051179
name: localization
namespace: biological_process
alt_id: GO:1902578
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]
subset: goslim_pir
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
synonym: "single organism localization" RELATED [GOC:TermGenie]
synonym: "single-organism localization" RELATED []
is_a: GO:0008150 ! biological process
created_by: jl
creation_date: 2013-12-18T13:51:04Z

[Term]
id: GO:0051216
name: cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424]
synonym: "cartilage biogenesis" EXACT []
synonym: "cartilage biosynthesis" EXACT []
synonym: "cartilage element development" EXACT []
synonym: "cartilage formation" EXACT []
synonym: "cartilage organ development" EXACT []
synonym: "chondrogenesis" EXACT []
xref: Wikipedia:Chondrogenesis
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0007844 ! cartilage element
relationship: part_of GO:0001501 ! skeletal system development
relationship: part_of GO:0061448 ! connective tissue development
relationship: results_in_development_of UBERON:0007844 ! cartilage element

[Term]
id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of protein transport" NARROW []
synonym: "stimulation of protein transport" NARROW []
synonym: "up regulation of protein transport" EXACT []
synonym: "up-regulation of protein transport" EXACT []
synonym: "upregulation of protein transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904951 ! positive regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015031 ! protein transport
relationship: positively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015031 ! protein transport
relationship: regulates GO:0015031 ! protein transport

[Term]
id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of protein transport" EXACT []
synonym: "down-regulation of protein transport" EXACT []
synonym: "downregulation of protein transport" EXACT []
synonym: "inhibition of protein transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904950 ! negative regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015031 ! protein transport
relationship: negatively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_agr
subset: goslim_flybase_ribbon
subset: goslim_mouse
subset: goslim_pir
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI

[Term]
id: GO:0051236
name: establishment of RNA localization
namespace: biological_process
def: "The directed movement of RNA to a specific location." [GOC:ai]
synonym: "establishment of RNA localisation" EXACT [GOC:mah]
synonym: "RNA positioning" EXACT []
synonym: "RNA recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032501 ! multicellular organismal process
relationship: regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "activation of multicellular organismal process" NARROW []
synonym: "stimulation of multicellular organismal process" NARROW []
synonym: "up regulation of multicellular organismal process" EXACT []
synonym: "up-regulation of multicellular organismal process" EXACT []
synonym: "upregulation of multicellular organismal process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032501 ! multicellular organismal process
relationship: positively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "down regulation of multicellular organismal process" EXACT []
synonym: "down-regulation of multicellular organismal process" EXACT []
synonym: "downregulation of multicellular organismal process" EXACT []
synonym: "inhibition of multicellular organismal process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032501 ! multicellular organismal process
relationship: negatively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032268
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "regulation of cellular protein metabolic process" RELATED []
synonym: "regulation of cellular protein metabolism" RELATED []
synonym: "regulation of protein metabolism" EXACT []
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019538 ! protein metabolic process
relationship: regulates GO:0019538 ! protein metabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032270
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "activation of cellular protein metabolic process" NARROW []
synonym: "activation of protein metabolic process" NARROW []
synonym: "positive regulation of cellular protein metabolic process" EXACT []
synonym: "positive regulation of cellular protein metabolism" EXACT []
synonym: "positive regulation of protein metabolism" EXACT []
synonym: "stimulation of cellular protein metabolic process" NARROW []
synonym: "stimulation of protein metabolic process" NARROW []
synonym: "up regulation of cellular protein metabolic process" EXACT []
synonym: "up regulation of protein metabolic process" EXACT []
synonym: "up-regulation of cellular protein metabolic process" EXACT []
synonym: "up-regulation of protein metabolic process" EXACT []
synonym: "upregulation of cellular protein metabolic process" EXACT []
synonym: "upregulation of protein metabolic process" EXACT []
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019538 ! protein metabolic process
relationship: positively_regulates GO:0019538 ! protein metabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
alt_id: GO:0032269
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]
synonym: "down regulation of cellular protein metabolic process" EXACT []
synonym: "down regulation of protein metabolic process" EXACT []
synonym: "down-regulation of cellular protein metabolic process" EXACT []
synonym: "down-regulation of protein metabolic process" EXACT []
synonym: "downregulation of cellular protein metabolic process" EXACT []
synonym: "downregulation of protein metabolic process" EXACT []
synonym: "inhibition of cellular protein metabolic process" NARROW []
synonym: "inhibition of protein metabolic process" NARROW []
synonym: "negative regulation of cellular protein metabolic process" EXACT []
synonym: "negative regulation of cellular protein metabolism" EXACT []
synonym: "negative regulation of protein metabolism" EXACT []
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019538 ! protein metabolic process
relationship: negatively_regulates GO:0019538 ! protein metabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23112" xsd:anyURI

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai]
is_a: GO:0002694 ! regulation of leukocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0046649 ! lymphocyte activation
relationship: regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "down regulation of lymphocyte activation" EXACT []
synonym: "down-regulation of lymphocyte activation" EXACT []
synonym: "downregulation of lymphocyte activation" EXACT []
synonym: "inhibition of lymphocyte activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0046649 ! lymphocyte activation
relationship: negatively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "activation of lymphocyte activation" NARROW []
synonym: "stimulation of lymphocyte activation" NARROW []
synonym: "up regulation of lymphocyte activation" EXACT []
synonym: "up-regulation of lymphocyte activation" EXACT []
synonym: "upregulation of lymphocyte activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0046649 ! lymphocyte activation
relationship: positively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "regulation of RNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016070 ! RNA metabolic process
relationship: regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "down regulation of RNA metabolic process" EXACT []
synonym: "down-regulation of RNA metabolic process" EXACT []
synonym: "downregulation of RNA metabolic process" EXACT []
synonym: "inhibition of RNA metabolic process" NARROW []
synonym: "negative regulation of RNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process
relationship: negatively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
synonym: "activation of RNA metabolic process" NARROW []
synonym: "positive regulation of RNA metabolism" EXACT []
synonym: "stimulation of RNA metabolic process" NARROW []
synonym: "up regulation of RNA metabolic process" EXACT []
synonym: "up-regulation of RNA metabolic process" EXACT []
synonym: "upregulation of RNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016070 ! RNA metabolic process
relationship: positively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
is_a: GO:0065003 ! protein-containing complex assembly

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0032984 ! protein-containing complex disassembly

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
alt_id: GO:0006323
alt_id: GO:0007001
alt_id: GO:0051277
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "DNA condensation" EXACT []
synonym: "DNA packaging" NARROW []
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005694 ! chromosome
relationship: results_in_organization_of GO:0005694 ! chromosome
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22811" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/4585" xsd:anyURI

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_pir
xref: Wikipedia:Cell_division
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051302
name: regulation of cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051301 ! cell division
relationship: regulates GO:0051301 ! cell division

[Term]
id: GO:0051303
name: establishment of chromosome localization
namespace: biological_process
def: "The directed movement of a chromosome to a specific location." [GOC:ai]
synonym: "chromosome positioning" EXACT []
synonym: "establishment of chromosome localisation" EXACT [GOC:mah]
is_a: GO:0050000 ! chromosome localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: has_primary_input GO:0005694 ! chromosome

[Term]
id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
alt_id: GO:0007126
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]
comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle.
subset: goslim_drosophila
subset: goslim_yeast
synonym: "meiosis" RELATED []
xref: Wikipedia:Meiosis
is_a: GO:0007049 ! cell cycle
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0007049 ! cell cycle
intersection_of: has_part GO:0140013 ! meiotic nuclear division
relationship: has_part GO:0140013 ! meiotic nuclear division
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0019953 ! sexual reproduction
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24599" xsd:anyURI

[Term]
id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "hydrolase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016787 ! hydrolase activity
relationship: regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_annotate
subset: gocheck_do_not_manually_annotate
synonym: "transferase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016740 ! transferase activity
relationship: regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051345
name: positive regulation of hydrolase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "activation of hydrolase activity" NARROW []
synonym: "hydrolase activator" EXACT []
synonym: "stimulation of hydrolase activity" NARROW []
synonym: "up regulation of hydrolase activity" EXACT []
synonym: "up-regulation of hydrolase activity" EXACT []
synonym: "upregulation of hydrolase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016787 ! hydrolase activity
relationship: positively_regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051346
name: negative regulation of hydrolase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gocheck_do_not_annotate
synonym: "down regulation of hydrolase activity" EXACT []
synonym: "down-regulation of hydrolase activity" EXACT []
synonym: "downregulation of hydrolase activity" EXACT []
synonym: "hydrolase inhibitor" EXACT []
synonym: "inhibition of hydrolase activity" NARROW []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016787 ! hydrolase activity
relationship: negatively_regulates GO:0016787 ! hydrolase activity

[Term]
id: GO:0051347
name: positive regulation of transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_annotate
subset: gocheck_do_not_manually_annotate
synonym: "activation of transferase activity" NARROW []
synonym: "stimulation of transferase activity" NARROW []
synonym: "transferase activator" EXACT []
synonym: "up regulation of transferase activity" EXACT []
synonym: "up-regulation of transferase activity" EXACT []
synonym: "upregulation of transferase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016740 ! transferase activity
relationship: positively_regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051348
name: negative regulation of transferase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead.
subset: gocheck_do_not_annotate
subset: gocheck_do_not_manually_annotate
synonym: "down regulation of transferase activity" EXACT []
synonym: "down-regulation of transferase activity" EXACT []
synonym: "downregulation of transferase activity" EXACT []
synonym: "inhibition of transferase activity" NARROW []
synonym: "transferase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016740 ! transferase activity
relationship: negatively_regulates GO:0016740 ! transferase activity

[Term]
id: GO:0051402
name: neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]
synonym: "apoptosis of neuronal cells" EXACT []
synonym: "apoptosis of neurons" EXACT []
synonym: "neuron apoptosis" NARROW []
synonym: "neuron programmed cell death by apoptosis" EXACT []
synonym: "neuronal cell apoptosis" EXACT []
synonym: "neuronal cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neuronal cells by apoptosis" EXACT []
synonym: "programmed cell death of neurons by apoptosis" EXACT []
synonym: "programmed cell death, neuronal cells" EXACT []
synonym: "programmed cell death, neurons" EXACT []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000540 ! neuron
relationship: occurs_in CL:0000540 ! neuron

[Term]
id: GO:0051410
name: detoxification of nitrogen compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai]
synonym: "detoxification of nitrogenous compound" EXACT []
synonym: "nitric oxide (NO) detoxification" NARROW []
is_a: GO:0098754 ! detoxification
intersection_of: GO:0098754 ! detoxification
intersection_of: has_primary_input CHEBI:51143 ! nitrogen molecular entity
relationship: has_primary_input CHEBI:51143 ! nitrogen molecular entity
relationship: part_of GO:1901698 ! response to nitrogen compound

[Term]
id: GO:0051445
name: regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051321 ! meiotic cell cycle
relationship: regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051446
name: positive regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051321 ! meiotic cell cycle
relationship: positively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051447
name: negative regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle
relationship: negatively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051450
name: myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000056 ! myoblast
relationship: acts_on_population_of CL:0000056 ! myoblast

[Term]
id: GO:0051451
name: myoblast migration
namespace: biological_process
def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000056 ! myoblast
relationship: results_in_movement_of CL:0000056 ! myoblast

[Term]
id: GO:0051469
name: vesicle fusion with vacuole
namespace: biological_process
alt_id: GO:0042146
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai]
synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED []
synonym: "heterotypic vacuole fusion, non-autophagic" RELATED []
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0097576 ! vacuole fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0005773 ! vacuole
intersection_of: results_in_fusion_of GO:0031982 ! vesicle
relationship: results_in_fusion_of GO:0031982 ! vesicle

[Term]
id: GO:0051493
name: regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007010 ! cytoskeleton organization
relationship: regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051494
name: negative regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "down regulation of cytoskeleton organization" EXACT []
synonym: "down-regulation of cytoskeleton organization" EXACT []
synonym: "downregulation of cytoskeleton organization" EXACT []
synonym: "inhibition of cytoskeleton organization" NARROW []
synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007010 ! cytoskeleton organization
relationship: negatively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051495
name: positive regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "activation of cytoskeleton organization" NARROW []
synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah]
synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cytoskeleton organization" NARROW []
synonym: "up regulation of cytoskeleton organization" EXACT []
synonym: "up-regulation of cytoskeleton organization" EXACT []
synonym: "upregulation of cytoskeleton organization" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007010 ! cytoskeleton organization
relationship: positively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051588
name: regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006836 ! neurotransmitter transport
relationship: regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051589
name: negative regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of neurotransmitter transport" EXACT []
synonym: "down-regulation of neurotransmitter transport" EXACT []
synonym: "downregulation of neurotransmitter transport" EXACT []
synonym: "inhibition of neurotransmitter transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006836 ! neurotransmitter transport
relationship: negatively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051590
name: positive regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of neurotransmitter transport" NARROW []
synonym: "stimulation of neurotransmitter transport" NARROW []
synonym: "up regulation of neurotransmitter transport" EXACT []
synonym: "up-regulation of neurotransmitter transport" EXACT []
synonym: "upregulation of neurotransmitter transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006836 ! neurotransmitter transport
relationship: positively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051602
name: response to electrical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai]
synonym: "response to electricity" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051620
name: norepinephrine uptake
namespace: biological_process
def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "levarterenol reuptake" EXACT []
synonym: "levarterenol uptake" EXACT []
synonym: "noradrenaline reuptake" EXACT []
synonym: "noradrenaline uptake" EXACT []
synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "norepinephrine reuptake" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0090493 ! catecholamine uptake
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure
intersection_of: has_target_start_location GO:0005576 ! extracellular region

[Term]
id: GO:0051621
name: regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai]
synonym: "regulation of levarterenol uptake" EXACT []
synonym: "regulation of noradrenaline uptake" EXACT []
synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051620 ! norepinephrine uptake
relationship: regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051622
name: negative regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "down regulation of norepinephrine uptake" EXACT []
synonym: "down-regulation of norepinephrine uptake" EXACT []
synonym: "downregulation of norepinephrine uptake" EXACT []
synonym: "negative regulation of levarterenol uptake" EXACT []
synonym: "negative regulation of noradrenaline uptake" EXACT []
synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051620 ! norepinephrine uptake
relationship: negatively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051623
name: positive regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "activation of norepinephrine uptake" NARROW []
synonym: "positive regulation of levarterenol uptake" EXACT []
synonym: "positive regulation of noradrenaline uptake" EXACT []
synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of norepinephrine uptake" NARROW []
synonym: "up regulation of norepinephrine uptake" EXACT []
synonym: "up-regulation of norepinephrine uptake" EXACT []
synonym: "upregulation of norepinephrine uptake" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051621 ! regulation of norepinephrine uptake
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051620 ! norepinephrine uptake
relationship: positively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051630
name: acetylcholine uptake
namespace: biological_process
def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai]
synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015870 ! acetylcholine transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure
intersection_of: has_target_start_location GO:0005576 ! extracellular region
relationship: has_target_end_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_start_location GO:0005576 ! extracellular region

[Term]
id: GO:0051631
name: regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051630 ! acetylcholine uptake
relationship: regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051632
name: negative regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "down regulation of acetylcholine uptake" EXACT []
synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051630 ! acetylcholine uptake
relationship: negatively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051633
name: positive regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "activation of acetylcholine uptake" NARROW []
synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of acetylcholine uptake" NARROW []
synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051630 ! acetylcholine uptake
relationship: positively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
synonym: "organelle localisation" EXACT [GOC:mah]
is_a: GO:0051179 ! localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0043226 ! organelle
relationship: has_primary_input GO:0043226 ! organelle
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19809" xsd:anyURI

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
alt_id: GO:1902580
def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]
subset: goslim_pir
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
synonym: "single organism cellular localization" EXACT [GOC:TermGenie]
synonym: "single-organism cellular localization" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
created_by: jl
creation_date: 2013-12-18T14:04:32Z

[Term]
id: GO:0051645
name: Golgi localization
namespace: biological_process
def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of Golgi localization" EXACT []
synonym: "Golgi apparatus localization" EXACT []
synonym: "Golgi body localization" EXACT []
synonym: "Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0005794 ! Golgi apparatus
relationship: has_primary_input GO:0005794 ! Golgi apparatus

[Term]
id: GO:0051647
name: nucleus localization
namespace: biological_process
def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "cell nucleus localization" EXACT []
synonym: "establishment and maintenance of nucleus localization" EXACT []
synonym: "localization of nucleus" EXACT []
synonym: "nucleus localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0005634 ! nucleus
relationship: has_primary_input GO:0005634 ! nucleus

[Term]
id: GO:0051648
name: vesicle localization
namespace: biological_process
def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cytoplasmic vesicle localization" EXACT []
synonym: "establishment and maintenance of vesicle localization" EXACT []
synonym: "vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0031982 ! vesicle
relationship: has_primary_input GO:0031982 ! vesicle

[Term]
id: GO:0051649
name: establishment of localization in cell
namespace: biological_process
def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of intracellular localization" NARROW []
synonym: "establishment of localisation in cell" EXACT [GOC:mah]
synonym: "establishment of localization within cell" NARROW []
synonym: "positioning within cell" NARROW []
is_a: GO:0051234 ! establishment of localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: occurs_in CL:0000000 ! cell
relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms
relationship: occurs_in CL:0000000 ! cell
relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051650
name: establishment of vesicle localization
namespace: biological_process
def: "The directed movement of a vesicle to a specific location." [GOC:ai]
synonym: "establishment of vesicle localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: has_primary_input GO:0031982 ! vesicle

[Term]
id: GO:0051656
name: establishment of organelle localization
namespace: biological_process
def: "The directed movement of an organelle to a specific location." [GOC:ai]
synonym: "establishment of organelle localisation" EXACT [GOC:mah]
is_a: GO:0051234 ! establishment of localization
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: has_primary_input GO:0043226 ! organelle

[Term]
id: GO:0051668
name: localization within membrane
namespace: biological_process
def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]
synonym: "establishment and maintenance of localization in membrane" EXACT []
synonym: "establishment and maintenance of position in membrane" EXACT []
synonym: "localisation within membrane" EXACT [GOC:mah]
synonym: "localization to membrane" EXACT []
synonym: "positioning within membrane" NARROW []
is_a: GO:0051641 ! cellular localization
intersection_of: GO:0051179 ! localization
intersection_of: has_target_end_location GO:0016020 ! membrane
relationship: has_target_end_location GO:0016020 ! membrane

[Term]
id: GO:0051674
name: localization of cell
namespace: biological_process
def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cell localization" EXACT []
synonym: "establishment and maintenance of cell localization" EXACT []
synonym: "establishment and maintenance of localization of cell" EXACT []
synonym: "localisation of cell" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input CL:0000000 ! cell
relationship: has_primary_input CL:0000000 ! cell

[Term]
id: GO:0051683
name: establishment of Golgi localization
namespace: biological_process
def: "The directed movement of the Golgi to a specific location." [GOC:ai]
synonym: "establishment of Golgi apparatus localization" EXACT []
synonym: "establishment of Golgi body localization" EXACT []
synonym: "establishment of Golgi localisation" EXACT [GOC:mah]
is_a: GO:0051645 ! Golgi localization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0051234 ! establishment of localization
intersection_of: has_primary_input GO:0005794 ! Golgi apparatus

[Term]
id: GO:0051707
name: response to other organism
namespace: biological_process
alt_id: GO:0009613
alt_id: GO:0042828
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input NCBITaxon_Union:0000030
relationship: has_primary_input NCBITaxon_Union:0000030

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051726
name: regulation of cell cycle
namespace: biological_process
alt_id: GO:0000074
alt_id: GO:0007050
alt_id: GO:0071156
alt_id: GO:0071157
alt_id: GO:0071158
alt_id: GO:0071850
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah]
synonym: "cell cycle arrest" NARROW []
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
synonym: "cell cycle regulator" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "mitotic cell cycle arrest" NARROW []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "negative regulation of cell cycle arrest" NARROW []
synonym: "positive regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle arrest" NARROW []
synonym: "regulation of cell cycle progression" EXACT []
synonym: "regulation of progression through cell cycle" EXACT []
synonym: "tumor suppressor" RELATED []
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007049 ! cell cycle
relationship: regulates GO:0007049 ! cell cycle

[Term]
id: GO:0051781
name: positive regulation of cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
synonym: "activation of cell division" NARROW []
synonym: "stimulation of cell division" NARROW []
synonym: "up regulation of cell division" EXACT []
synonym: "up-regulation of cell division" EXACT []
synonym: "upregulation of cell division" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051301 ! cell division
relationship: positively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051782
name: negative regulation of cell division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai]
synonym: "down regulation of cell division" EXACT []
synonym: "down-regulation of cell division" EXACT []
synonym: "downregulation of cell division" EXACT []
synonym: "inhibition of cell division" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051301 ! cell division
relationship: negatively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051783
name: regulation of nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000280 ! nuclear division
relationship: regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051784
name: negative regulation of nuclear division
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "down regulation of nuclear division" EXACT []
synonym: "down-regulation of nuclear division" EXACT []
synonym: "downregulation of nuclear division" EXACT []
synonym: "inhibition of nuclear division" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000280 ! nuclear division
relationship: negatively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051785
name: positive regulation of nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "activation of nuclear division" NARROW []
synonym: "stimulation of nuclear division" NARROW []
synonym: "up regulation of nuclear division" EXACT []
synonym: "up-regulation of nuclear division" EXACT []
synonym: "upregulation of nuclear division" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000280 ! nuclear division
relationship: positively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051875
name: pigment granule localization
namespace: biological_process
def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051648 ! vesicle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0048770 ! pigment granule
relationship: has_primary_input GO:0048770 ! pigment granule
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0051890
name: regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
is_a: GO:1905207 ! regulation of cardiocyte differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010002 ! cardioblast differentiation
relationship: regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051891
name: positive regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "activation of cardioblast differentiation" NARROW []
synonym: "stimulation of cardioblast differentiation" NARROW []
synonym: "up regulation of cardioblast differentiation" EXACT []
synonym: "up-regulation of cardioblast differentiation" EXACT []
synonym: "upregulation of cardioblast differentiation" EXACT []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010002 ! cardioblast differentiation
relationship: positively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051892
name: negative regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "down regulation of cardioblast differentiation" EXACT []
synonym: "down-regulation of cardioblast differentiation" EXACT []
synonym: "downregulation of cardioblast differentiation" EXACT []
synonym: "inhibition of cardioblast differentiation" NARROW []
is_a: GO:0051890 ! regulation of cardioblast differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010002 ! cardioblast differentiation
relationship: negatively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051904
name: pigment granule transport
namespace: biological_process
def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "pigment granule translocation" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0051875 ! pigment granule localization
is_a: GO:0051905 ! establishment of pigment granule localization
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input GO:0048770 ! pigment granule

[Term]
id: GO:0051905
name: establishment of pigment granule localization
namespace: biological_process
def: "The directed movement of a pigment granule to a specific location." [GOC:ai]
synonym: "establishment of pigment granule localisation" EXACT [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051930
name: regulation of sensory perception of pain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0051931 ! regulation of sensory perception
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019233 ! sensory perception of pain
relationship: regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:0051931
name: regulation of sensory perception
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0031644 ! regulation of nervous system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007600 ! sensory perception
relationship: regulates GO:0007600 ! sensory perception

[Term]
id: GO:0051937
name: catecholamine transport
namespace: biological_process
def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732]
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic hydroxy compound transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33567 ! catecholamine
relationship: has_primary_input CHEBI:33567 ! catecholamine

[Term]
id: GO:0051952
name: regulation of amine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015837 ! amine transport
relationship: regulates GO:0015837 ! amine transport

[Term]
id: GO:0051953
name: negative regulation of amine transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amine transport" EXACT []
synonym: "down-regulation of amine transport" EXACT []
synonym: "downregulation of amine transport" EXACT []
synonym: "inhibition of amine transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015837 ! amine transport
relationship: negatively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051954
name: positive regulation of amine transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amine transport" NARROW []
synonym: "stimulation of amine transport" NARROW []
synonym: "up regulation of amine transport" EXACT []
synonym: "up-regulation of amine transport" EXACT []
synonym: "upregulation of amine transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015837 ! amine transport
relationship: positively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051955
name: regulation of amino acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051952 ! regulation of amine transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006865 ! amino acid transport
relationship: regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051956
name: negative regulation of amino acid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amino acid transport" EXACT []
synonym: "down-regulation of amino acid transport" EXACT []
synonym: "downregulation of amino acid transport" EXACT []
synonym: "inhibition of amino acid transport" NARROW []
synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006865 ! amino acid transport
relationship: negatively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051957
name: positive regulation of amino acid transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amino acid transport" NARROW []
synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah]
synonym: "stimulation of amino acid transport" NARROW []
synonym: "up regulation of amino acid transport" EXACT []
synonym: "up-regulation of amino acid transport" EXACT []
synonym: "upregulation of amino acid transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006865 ! amino acid transport
relationship: positively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051960
name: regulation of nervous system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007399 ! nervous system development
relationship: regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051961
name: negative regulation of nervous system development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "down regulation of nervous system development" EXACT []
synonym: "down-regulation of nervous system development" EXACT []
synonym: "downregulation of nervous system development" EXACT []
synonym: "inhibition of nervous system development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007399 ! nervous system development
relationship: negatively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051962
name: positive regulation of nervous system development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "activation of nervous system development" NARROW []
synonym: "stimulation of nervous system development" NARROW []
synonym: "up regulation of nervous system development" EXACT []
synonym: "up-regulation of nervous system development" EXACT []
synonym: "upregulation of nervous system development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051960 ! regulation of nervous system development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007399 ! nervous system development
relationship: positively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051963
name: regulation of synapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
subset: goslim_synapse
synonym: "regulation of synapse biogenesis" EXACT []
synonym: "regulation of synaptogenesis" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007416 ! synapse assembly
relationship: regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051964
name: negative regulation of synapse assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "down regulation of synapse assembly" EXACT []
synonym: "down-regulation of synapse assembly" EXACT []
synonym: "downregulation of synapse assembly" EXACT []
synonym: "inhibition of synapse assembly" NARROW []
synonym: "negative regulation of synapse biogenesis" EXACT []
synonym: "negative regulation of synaptogenesis" EXACT []
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901889 ! negative regulation of cell junction assembly
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007416 ! synapse assembly
relationship: negatively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051965
name: positive regulation of synapse assembly
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]
synonym: "activation of synapse assembly" NARROW []
synonym: "positive regulation of synapse biogenesis" EXACT []
synonym: "positive regulation of synaptogenesis" EXACT []
synonym: "stimulation of synapse assembly" NARROW []
synonym: "up regulation of synapse assembly" EXACT []
synonym: "up-regulation of synapse assembly" EXACT []
synonym: "upregulation of synapse assembly" EXACT []
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:1901890 ! positive regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007416 ! synapse assembly
relationship: positively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051969
name: regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031644 ! regulation of nervous system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019226 ! transmission of nerve impulse
relationship: regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051970
name: negative regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "down regulation of transmission of nerve impulse" EXACT []
synonym: "down-regulation of transmission of nerve impulse" EXACT []
synonym: "downregulation of transmission of nerve impulse" EXACT []
synonym: "inhibition of transmission of nerve impulse" NARROW []
synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019226 ! transmission of nerve impulse
relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051971
name: positive regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "activation of transmission of nerve impulse" NARROW []
synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph]
synonym: "stimulation of transmission of nerve impulse" NARROW []
synonym: "up regulation of transmission of nerve impulse" EXACT []
synonym: "up-regulation of transmission of nerve impulse" EXACT []
synonym: "upregulation of transmission of nerve impulse" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019226 ! transmission of nerve impulse
relationship: positively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051983
name: regulation of chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007059 ! chromosome segregation
relationship: regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051984
name: positive regulation of chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "activation of chromosome segregation" NARROW []
synonym: "stimulation of chromosome segregation" NARROW []
synonym: "up regulation of chromosome segregation" EXACT []
synonym: "up-regulation of chromosome segregation" EXACT []
synonym: "upregulation of chromosome segregation" EXACT []
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0090068 ! positive regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007059 ! chromosome segregation
relationship: positively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051985
name: negative regulation of chromosome segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "down regulation of chromosome segregation" EXACT []
synonym: "down-regulation of chromosome segregation" EXACT []
synonym: "downregulation of chromosome segregation" EXACT []
synonym: "inhibition of chromosome segregation" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051983 ! regulation of chromosome segregation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007059 ! chromosome segregation
relationship: negatively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0055001
name: muscle cell development
namespace: biological_process
alt_id: GO:0048747
def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]
synonym: "muscle fiber development" EXACT []
synonym: "muscle fibre development" EXACT []
synonym: "myofiber development" EXACT []
synonym: "myofibre development" EXACT []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000187 ! muscle cell
relationship: part_of GO:0042692 ! muscle cell differentiation
relationship: results_in_development_of CL:0000187 ! muscle cell

[Term]
id: GO:0055002
name: striated muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol]
is_a: GO:0055001 ! muscle cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000737 ! striated muscle cell
relationship: part_of GO:0051146 ! striated muscle cell differentiation
relationship: results_in_development_of CL:0000737 ! striated muscle cell

[Term]
id: GO:0055003
name: cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "cardiac myofibril development" EXACT []
synonym: "cardiac myofibril morphogenesis" EXACT []
synonym: "heart myofibril assembly" RELATED []
is_a: GO:0030239 ! myofibril assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0097512 ! cardiac myofibril
relationship: part_of GO:0055013 ! cardiac muscle cell development
relationship: results_in_assembly_of GO:0097512 ! cardiac myofibril

[Term]
id: GO:0055006
name: cardiac cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]
synonym: "cardiocyte development" EXACT [GOC:dph]
synonym: "heart cell development" RELATED []
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0002494 ! cardiocyte
relationship: part_of GO:0035051 ! cardiocyte differentiation
relationship: results_in_development_of CL:0002494 ! cardiocyte

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
namespace: biological_process
def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte differentiation" EXACT []
synonym: "heart muscle cell differentiation" RELATED []
is_a: GO:0035051 ! cardiocyte differentiation
is_a: GO:0051146 ! striated muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000746 ! cardiac muscle cell
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: results_in_acquisition_of_features_of CL:0000746 ! cardiac muscle cell

[Term]
id: GO:0055008
name: cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol]
synonym: "heart muscle morphogenesis" EXACT []
synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001133 ! cardiac muscle tissue
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: results_in_morphogenesis_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: GO:0055009
name: atrial cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol]
synonym: "atrial heart muscle morphogenesis" EXACT []
synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac atrium muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004490 ! cardiac muscle tissue of atrium
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development
relationship: results_in_morphogenesis_of UBERON:0004490 ! cardiac muscle tissue of atrium

[Term]
id: GO:0055010
name: ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol]
synonym: "cardiac ventricle muscle morphogenesis" EXACT []
synonym: "ventricular heart muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0018649 ! cardiac muscle tissue of ventricle
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development
relationship: results_in_morphogenesis_of UBERON:0018649 ! cardiac muscle tissue of ventricle

[Term]
id: GO:0055013
name: cardiac muscle cell development
namespace: biological_process
alt_id: GO:0048739
def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiac muscle fiber development" EXACT []
synonym: "cardiac muscle fibre development" EXACT []
synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle]
synonym: "heart muscle cell development" EXACT []
synonym: "heart muscle fiber development" RELATED []
is_a: GO:0055002 ! striated muscle cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000746 ! cardiac muscle cell
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation
relationship: results_in_development_of CL:0000746 ! cardiac muscle cell

[Term]
id: GO:0055017
name: cardiac muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol]
synonym: "heart muscle growth" EXACT []
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0001133 ! cardiac muscle tissue
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0060419 ! heart growth
relationship: results_in_growth_of UBERON:0001133 ! cardiac muscle tissue

[Term]
id: GO:0055018
name: regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "regulation of cardiac muscle fibre development" EXACT []
synonym: "regulation of heart muscle fiber development" EXACT []
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055013 ! cardiac muscle cell development
relationship: regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055019
name: negative regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "down regulation of cardiac muscle fiber development" EXACT []
synonym: "down-regulation of cardiac muscle fiber development" EXACT []
synonym: "downregulation of cardiac muscle fiber development" EXACT []
synonym: "inhibition of cardiac muscle fiber development" NARROW []
synonym: "negative regulation of cardiac muscle fibre development" EXACT []
synonym: "negative regulation of heart muscle fiber development" RELATED []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055013 ! cardiac muscle cell development
relationship: negatively_regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055020
name: positive regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "activation of cardiac muscle fiber development" NARROW []
synonym: "positive regulation of cardiac muscle fibre development" EXACT []
synonym: "positive regulation of heart muscle fiber development" EXACT []
synonym: "stimulation of cardiac muscle fiber development" NARROW []
synonym: "up regulation of cardiac muscle fiber development" EXACT []
synonym: "up-regulation of cardiac muscle fiber development" EXACT []
synonym: "upregulation of cardiac muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055013 ! cardiac muscle cell development
relationship: positively_regulates GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055021
name: regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055017 ! cardiac muscle tissue growth
relationship: regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055022
name: negative regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "down regulation of cardiac muscle growth" EXACT []
synonym: "down-regulation of cardiac muscle growth" EXACT []
synonym: "downregulation of cardiac muscle growth" EXACT []
synonym: "inhibition of cardiac muscle growth" NARROW []
synonym: "negative regulation of heart muscle growth" RELATED []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0061117 ! negative regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055017 ! cardiac muscle tissue growth
relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055023
name: positive regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "activation of cardiac muscle growth" NARROW []
synonym: "positive regulation of heart muscle growth" EXACT []
synonym: "stimulation of cardiac muscle growth" NARROW []
synonym: "up regulation of cardiac muscle growth" EXACT []
synonym: "up-regulation of cardiac muscle growth" EXACT []
synonym: "upregulation of cardiac muscle growth" EXACT []
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
is_a: GO:0060421 ! positive regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055017 ! cardiac muscle tissue growth
relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055024
name: regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "regulation of heart muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048738 ! cardiac muscle tissue development
relationship: regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055025
name: positive regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "activation of cardiac muscle development" NARROW []
synonym: "positive regulation of heart muscle development" EXACT []
synonym: "stimulation of cardiac muscle development" NARROW []
synonym: "up regulation of cardiac muscle development" EXACT []
synonym: "up-regulation of cardiac muscle development" EXACT []
synonym: "upregulation of cardiac muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048738 ! cardiac muscle tissue development
relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055026
name: negative regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "down regulation of cardiac muscle development" EXACT []
synonym: "down-regulation of cardiac muscle development" EXACT []
synonym: "downregulation of cardiac muscle development" EXACT []
synonym: "inhibition of cardiac muscle development" NARROW []
synonym: "negative regulation of heart muscle development" EXACT []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048738 ! cardiac muscle tissue development
relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055057
name: neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
synonym: "neuroblast cell division" EXACT []
is_a: GO:0051301 ! cell division
intersection_of: GO:0051301 ! cell division
intersection_of: has_primary_input CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: has_primary_input CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0055059
name: asymmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0055057 ! neuroblast division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: has_primary_input CL:0000031 ! neuroblast (sensu Vertebrata)

[Term]
id: GO:0055085
name: transmembrane transport
namespace: biological_process
alt_id: GO:0090662
def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
synonym: "ATP hydrolysis coupled transmembrane transport" NARROW []
synonym: "membrane transport" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: results_in_transport_across GO:0016020 ! membrane
created_by: tb
creation_date: 2015-10-21T13:22:47Z

[Term]
id: GO:0055086
name: nucleobase-containing small molecule metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw]
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
subset: goslim_yeast
synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED []
synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT []
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0055107
name: Golgi to secretory granule transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: has_target_end_location GO:0030141 ! secretory granule
intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: has_target_end_location GO:0030141 ! secretory granule
relationship: has_target_start_location GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0055108
name: Golgi to transport vesicle transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid]
is_a: GO:0046907 ! intracellular transport
intersection_of: GO:0006810 ! transport
intersection_of: has_target_end_location GO:0030133 ! transport vesicle
intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus
intersection_of: occurs_in GO:0005737 ! cytoplasm
relationship: has_target_end_location GO:0030133 ! transport vesicle
relationship: has_target_start_location GO:0005794 ! Golgi apparatus
relationship: occurs_in GO:0005737 ! cytoplasm
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0055111
name: ingression involved in gastrulation with mouth forming second
namespace: biological_process
def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0042074 ! cell migration involved in gastrulation
intersection_of: GO:0001667 ! ameboidal-type cell migration
intersection_of: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055117
name: regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060048 ! cardiac muscle contraction
relationship: regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055118
name: negative regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0045822 ! negative regulation of heart contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060048 ! cardiac muscle contraction
relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055123
name: digestive system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001007 ! digestive system
relationship: results_in_development_of UBERON:0001007 ! digestive system

[Term]
id: GO:0060008
name: Sertoli cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000216 ! Sertoli cell
relationship: part_of GO:0008584 ! male gonad development
relationship: results_in_acquisition_of_features_of CL:0000216 ! Sertoli cell

[Term]
id: GO:0060009
name: Sertoli cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0003006 ! developmental process involved in reproduction
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000216 ! Sertoli cell
relationship: part_of GO:0060008 ! Sertoli cell differentiation
relationship: results_in_development_of CL:0000216 ! Sertoli cell

[Term]
id: GO:0060011
name: Sertoli cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000216 ! Sertoli cell
relationship: acts_on_population_of CL:0000216 ! Sertoli cell
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060021
name: roof of mouth development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544]
synonym: "palatum development" EXACT [ISBN:0721662544]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0007375 ! roof of mouth
relationship: results_in_development_of UBERON:0007375 ! roof of mouth

[Term]
id: GO:0060037
name: pharyngeal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0008814 ! pharyngeal arch system
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: results_in_development_of UBERON:0008814 ! pharyngeal arch system

[Term]
id: GO:0060038
name: cardiac muscle cell proliferation
namespace: biological_process
def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571]
synonym: "cardiac myocyte proliferation" EXACT []
synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473]
synonym: "heart muscle cell proliferation" EXACT []
is_a: GO:0014855 ! striated muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000746 ! cardiac muscle cell
relationship: acts_on_population_of CL:0000746 ! cardiac muscle cell
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0060039
name: pericardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002407 ! pericardium
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0002407 ! pericardium

[Term]
id: GO:0060041
name: retina development in camera-type eye
namespace: biological_process
alt_id: GO:0002073
def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729]
synonym: "retina development in camera-style eye" EXACT []
synonym: "retinal development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: part_of GO:0043010 ! camera-type eye development
intersection_of: results_in_development_of UBERON:0000966 ! retina
relationship: part_of GO:0043010 ! camera-type eye development
relationship: results_in_development_of UBERON:0000966 ! retina

[Term]
id: GO:0060042
name: retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu]
synonym: "retina morphogenesis in camera-style eye" EXACT []
synonym: "retinogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000966 ! retina
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0060041 ! retina development in camera-type eye
relationship: results_in_morphogenesis_of UBERON:0000966 ! retina

[Term]
id: GO:0060043
name: regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph]
synonym: "regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060044
name: negative regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "negative regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060045
name: positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "positive regulation of heart muscle cell proliferation" RELATED []
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060038 ! cardiac muscle cell proliferation
relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060047
name: heart contraction
namespace: biological_process
def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
synonym: "cardiac contraction" RELATED []
synonym: "heart beating" EXACT []
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003015 ! heart process
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0060048
name: cardiac muscle contraction
namespace: biological_process
def: "Muscle contraction of cardiac muscle tissue." [GOC:dph]
synonym: "heart muscle contraction" EXACT []
is_a: GO:0006941 ! striated muscle contraction
intersection_of: GO:0006936 ! muscle contraction
intersection_of: occurs_in UBERON:0001133 ! cardiac muscle tissue
relationship: occurs_in UBERON:0001133 ! cardiac muscle tissue
relationship: part_of GO:0060047 ! heart contraction

[Term]
id: GO:0060065
name: uterus development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048513 ! animal organ development
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000995 ! uterus
relationship: results_in_development_of UBERON:0000995 ! uterus

[Term]
id: GO:0060066
name: oviduct development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct]
synonym: "fallopian tube development" NARROW [GOC:bf]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003889 ! fallopian tube
relationship: results_in_development_of UBERON:0003889 ! fallopian tube

[Term]
id: GO:0060073
name: micturition
namespace: biological_process
def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph]
synonym: "urination" EXACT []
synonym: "urine voiding" EXACT []
xref: Wikipedia:Urination
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion

[Term]
id: GO:0060083
name: smooth muscle contraction involved in micturition
namespace: biological_process
def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347]
synonym: "smooth muscle contraction involved in urination" RELATED []
synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph]
is_a: GO:0014832 ! urinary bladder smooth muscle contraction
intersection_of: GO:0006939 ! smooth muscle contraction
intersection_of: part_of GO:0060073 ! micturition
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060084
name: synaptic transmission involved in micturition
namespace: biological_process
def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" RELATED []
is_a: GO:0007274 ! neuromuscular synaptic transmission
intersection_of: GO:0007268 ! chemical synaptic transmission
intersection_of: part_of GO:0060073 ! micturition
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
namespace: biological_process
def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph]
synonym: "serotonin release, neurotransmission" RELATED [GOC:tb]
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+)

[Term]
id: GO:0060135
name: maternal process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0060136
name: embryonic process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph]
is_a: GO:0048609 ! multicellular organismal reproductive process
intersection_of: GO:0022414 ! reproductive process
intersection_of: part_of GO:0007565 ! female pregnancy
intersection_of: part_of GO:0009790 ! embryo development
relationship: part_of GO:0007565 ! female pregnancy
relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0060142
name: regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060143
name: positive regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060157
name: urinary bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, PMID:11768524, PMID:18276178, PMID:538956]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001255 ! urinary bladder
relationship: part_of GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0001255 ! urinary bladder
property_value: RO:0002161 NCBITaxon:8782

[Term]
id: GO:0060170
name: ciliary membrane
namespace: cellular_component
alt_id: GO:0020017
def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]
comment: Note that cilia and eukaryotic flagella are deemed to be equivalent.
synonym: "cilial membrane" EXACT []
synonym: "cilium membrane" EXACT []
synonym: "flagellar membrane" NARROW []
synonym: "flagellum membrane" NARROW []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0005929 ! cilium
relationship: bounding_layer_of GO:0005929 ! cilium
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0060173
name: limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]
synonym: "limb bud development" NARROW [GOC:dph]
synonym: "paired limb/fin development" EXACT []
xref: Wikipedia:Limb_development
is_a: GO:0048736 ! appendage development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004708 ! paired limb/fin
relationship: results_in_development_of UBERON:0004708 ! paired limb/fin

[Term]
id: GO:0060214
name: endocardium formation
namespace: biological_process
def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002165 ! endocardium
relationship: part_of GO:0003160 ! endocardium morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002165 ! endocardium

[Term]
id: GO:0060218
name: hematopoietic stem cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083]
synonym: "haematopoietic stem cell differentiation" EXACT []
synonym: "haemopoietic stem cell differentiation" EXACT []
synonym: "hemopoietic stem cell differentiation" EXACT []
is_a: GO:0002244 ! hematopoietic progenitor cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000037 ! hematopoietic stem cell
relationship: results_in_acquisition_of_features_of CL:0000037 ! hematopoietic stem cell

[Term]
id: GO:0060219
name: camera-type eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010009 ! camera-type eye photoreceptor cell
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye
relationship: results_in_acquisition_of_features_of CL:0010009 ! camera-type eye photoreceptor cell

[Term]
id: GO:0060221
name: retinal rod cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000604 ! retinal rod cell
relationship: results_in_acquisition_of_features_of CL:0000604 ! retinal rod cell

[Term]
id: GO:0060231
name: mesenchymal to epithelial transition
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl]
synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: has_primary_input CL:0008019 ! mesenchymal cell
intersection_of: results_in_acquisition_of_features_of CL:0000066 ! epithelial cell
relationship: has_primary_input CL:0008019 ! mesenchymal cell

[Term]
id: GO:0060251
name: regulation of glial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014009 ! glial cell proliferation
relationship: regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060252
name: positive regulation of glial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014009 ! glial cell proliferation
relationship: positively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060253
name: negative regulation of glial cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014009 ! glial cell proliferation
relationship: negatively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043170 ! macromolecule metabolic process
relationship: regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0060271
name: cilium assembly
namespace: biological_process
alt_id: GO:0042384
def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "ciliogenesis" EXACT []
synonym: "cilium biogenesis" RELATED [GOC:mah]
synonym: "cilium formation" EXACT []
synonym: "cilium morphogenesis" RELATED []
synonym: "cilium organization" RELATED [GOC:dph]
synonym: "microtubule-based flagellum assembly" EXACT []
xref: Reactome:R-HSA-5617833.2
is_a: GO:0044782 ! cilium organization
is_a: GO:0070925 ! organelle assembly
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005929 ! cilium
relationship: has_part GO:0035082 ! axoneme assembly
relationship: has_part GO:0035735 ! intraciliary transport involved in cilium assembly
relationship: has_part GO:0061512 ! protein localization to cilium
relationship: has_part GO:0097712 ! vesicle targeting, trans-Golgi to periciliary membrane compartment
relationship: has_part GO:1905349 ! ciliary transition zone assembly
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: results_in_assembly_of GO:0005929 ! cilium
relationship: starts_with GO:0097711 ! ciliary basal body-plasma membrane docking
property_value: RO:0002161 NCBITaxon:3176
property_value: RO:0002161 NCBITaxon:3312
property_value: RO:0002161 NCBITaxon:3378
property_value: RO:0002161 NCBITaxon:3398
property_value: RO:0002161 NCBITaxon:4890
property_value: RO:0002161 NCBITaxon:5782

[Term]
id: GO:0060281
name: regulation of oocyte development
namespace: biological_process
def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318]
is_a: GO:1905879 ! regulation of oogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048599 ! oocyte development
relationship: regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060282
name: positive regulation of oocyte development
namespace: biological_process
def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048599 ! oocyte development
relationship: positively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060283
name: negative regulation of oocyte development
namespace: biological_process
def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048599 ! oocyte development
relationship: negatively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060284
name: regulation of cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048468 ! cell development
relationship: regulates GO:0048468 ! cell development

[Term]
id: GO:0060285
name: cilium-dependent cell motility
namespace: biological_process
alt_id: GO:0071974
def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]
comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent.
synonym: "ciliary cell motility" RELATED []
synonym: "cilium cell motility" EXACT []
synonym: "microtubule-based flagellar cell motility" EXACT []
is_a: GO:0001539 ! cilium or flagellum-dependent cell motility
relationship: has_part GO:0003341 ! cilium movement

[Term]
id: GO:0060294
name: cilium movement involved in cell motility
namespace: biological_process
def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
intersection_of: GO:0003341 ! cilium movement
intersection_of: part_of GO:0048870 ! cell motility
relationship: part_of GO:0060285 ! cilium-dependent cell motility

[Term]
id: GO:0060295
name: regulation of cilium movement involved in cell motility
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060294 ! cilium movement involved in cell motility
relationship: regulates GO:0060294 ! cilium movement involved in cell motility

[Term]
id: GO:0060297
name: regulation of sarcomere organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045214 ! sarcomere organization
relationship: regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060298
name: positive regulation of sarcomere organization
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045214 ! sarcomere organization
relationship: positively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060299
name: negative regulation of sarcomere organization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045214 ! sarcomere organization
relationship: negatively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060322
name: head development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000033 ! head
relationship: results_in_development_of UBERON:0000033 ! head

[Term]
id: GO:0060323
name: head morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000033 ! head
relationship: part_of GO:0010171 ! body morphogenesis
relationship: part_of GO:0060322 ! head development
relationship: results_in_morphogenesis_of UBERON:0000033 ! head

[Term]
id: GO:0060324
name: face development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001456 ! face
relationship: part_of GO:0060322 ! head development
relationship: results_in_development_of UBERON:0001456 ! face

[Term]
id: GO:0060325
name: face morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001456 ! face
relationship: part_of GO:0060323 ! head morphogenesis
relationship: part_of GO:0060324 ! face development
relationship: results_in_morphogenesis_of UBERON:0001456 ! face

[Term]
id: GO:0060341
name: regulation of cellular localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cellular localisation" EXACT [GOC:mah]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051641 ! cellular localization
relationship: regulates GO:0051641 ! cellular localization

[Term]
id: GO:0060343
name: trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
synonym: "trabecula biogenesis" RELATED [GOC:dph]
synonym: "trabeculation" EXACT [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000440 ! trabecula
relationship: part_of GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0061383 ! trabecula morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000440 ! trabecula

[Term]
id: GO:0060344
name: liver trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "liver trabecula biogenesis" RELATED []
synonym: "liver trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0010183 ! liver trabecula
relationship: part_of GO:0001889 ! liver development
relationship: results_in_formation_of_anatomical_entity UBERON:0010183 ! liver trabecula

[Term]
id: GO:0060345
name: spleen trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "spleen trabecula biogenesis" RELATED [GOC:dph]
synonym: "spleen trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001265 ! trabecula of spleen
relationship: part_of GO:0048536 ! spleen development
relationship: results_in_formation_of_anatomical_entity UBERON:0001265 ! trabecula of spleen

[Term]
id: GO:0060347
name: heart trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "cardiac trabecula formation" EXACT [GOC:dph]
synonym: "cardiac trabeculation" EXACT [GOC:dph]
synonym: "heart trabecula biogenesis" RELATED [GOC:dph]
synonym: "heart trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002511 ! trabecula carnea
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0061384 ! heart trabecula morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002511 ! trabecula carnea

[Term]
id: GO:0060348
name: bone development
namespace: biological_process
def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048513 ! animal organ development
intersection_of: results_in_development_of UBERON:0001474 ! bone element
relationship: part_of GO:0001501 ! skeletal system development
relationship: results_in_development_of UBERON:0001474 ! bone element

[Term]
id: GO:0060349
name: bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001474 ! bone element
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0060348 ! bone development
relationship: results_in_morphogenesis_of UBERON:0001474 ! bone element

[Term]
id: GO:0060350
name: endochondral bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002513 ! endochondral bone
relationship: results_in_morphogenesis_of UBERON:0002513 ! endochondral bone

[Term]
id: GO:0060351
name: cartilage development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph]
is_a: GO:0051216 ! cartilage development
intersection_of: GO:0051216 ! cartilage development
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0060359
name: response to ammonium ion
namespace: biological_process
alt_id: GO:1903717
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267]
synonym: "response to ammonia" EXACT []
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:28938 ! ammonium
relationship: has_primary_input CHEBI:28938 ! ammonium

[Term]
id: GO:0060379
name: cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]
synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb]
synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
is_a: GO:0045445 ! myoblast differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000513 ! cardiac muscle myoblast
relationship: results_in_acquisition_of_features_of CL:0000513 ! cardiac muscle myoblast

[Term]
id: GO:0060404
name: axonemal microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010938 ! cytoplasmic microtubule depolymerization
is_a: GO:0061523 ! cilium disassembly
intersection_of: GO:0007019 ! microtubule depolymerization
intersection_of: occurs_in GO:0005930 ! axoneme
relationship: occurs_in GO:0005930 ! axoneme

[Term]
id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033238 ! regulation of amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008291 ! acetylcholine metabolic process
relationship: regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033240 ! positive regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008291 ! acetylcholine metabolic process
relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033239 ! negative regulation of amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008291 ! acetylcholine metabolic process
relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060411
name: cardiac septum morphogenesis
namespace: biological_process
alt_id: GO:0003280
def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]
synonym: "heart septum morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002099 ! cardiac septum
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003279 ! cardiac septum development
relationship: results_in_morphogenesis_of UBERON:0002099 ! cardiac septum

[Term]
id: GO:0060412
name: ventricular septum morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph]
synonym: "interventricular septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002094 ! interventricular septum
relationship: part_of GO:0003281 ! ventricular septum development
relationship: results_in_morphogenesis_of UBERON:0002094 ! interventricular septum

[Term]
id: GO:0060413
name: atrial septum morphogenesis
namespace: biological_process
alt_id: GO:0003287
def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart]
synonym: "interatrial septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002085 ! interatrial septum
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003283 ! atrial septum development
relationship: results_in_morphogenesis_of UBERON:0002085 ! interatrial septum

[Term]
id: GO:0060414
name: aorta smooth muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta]
is_a: GO:0060415 ! muscle tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004178 ! aorta smooth muscle tissue
relationship: part_of GO:0035909 ! aorta morphogenesis
relationship: part_of GO:0048745 ! smooth muscle tissue development
relationship: results_in_morphogenesis_of UBERON:0004178 ! aorta smooth muscle tissue

[Term]
id: GO:0060415
name: muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0048729 ! tissue morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002385 ! muscle tissue
relationship: part_of GO:0048644 ! muscle organ morphogenesis
relationship: results_in_morphogenesis_of UBERON:0002385 ! muscle tissue

[Term]
id: GO:0060419
name: heart growth
namespace: biological_process
def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0000948 ! heart
relationship: part_of GO:0007507 ! heart development
relationship: results_in_growth_of UBERON:0000948 ! heart

[Term]
id: GO:0060420
name: regulation of heart growth
namespace: biological_process
def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060419 ! heart growth
relationship: regulates GO:0060419 ! heart growth

[Term]
id: GO:0060421
name: positive regulation of heart growth
namespace: biological_process
def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060419 ! heart growth
relationship: positively_regulates GO:0060419 ! heart growth

[Term]
id: GO:0060425
name: lung morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002048 ! lung
relationship: part_of GO:0030324 ! lung development
relationship: results_in_morphogenesis_of UBERON:0002048 ! lung

[Term]
id: GO:0060426
name: lung vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0001944 ! vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000102 ! lung vasculature
relationship: part_of GO:0030324 ! lung development
relationship: results_in_development_of UBERON:0000102 ! lung vasculature

[Term]
id: GO:0060427
name: lung connective tissue development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary connective tissue development" EXACT []
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000114 ! lung connective tissue
relationship: part_of GO:0030324 ! lung development
relationship: results_in_development_of UBERON:0000114 ! lung connective tissue

[Term]
id: GO:0060428
name: lung epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000115 ! lung epithelium
relationship: part_of GO:0030324 ! lung development
relationship: results_in_development_of UBERON:0000115 ! lung epithelium

[Term]
id: GO:0060429
name: epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
subset: goslim_drosophila
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000483 ! epithelium
relationship: results_in_development_of UBERON:0000483 ! epithelium

[Term]
id: GO:0060431
name: primary lung bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung]
synonym: "lung formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! animal organ formation
is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis
is_a: GO:0060572 ! morphogenesis of an epithelial bud
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002048 ! lung
relationship: results_in_formation_of_anatomical_entity UBERON:0002048 ! lung

[Term]
id: GO:0060437
name: lung growth
namespace: biological_process
def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0002048 ! lung
relationship: part_of GO:0030324 ! lung development
relationship: results_in_growth_of UBERON:0002048 ! lung

[Term]
id: GO:0060438
name: trachea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001005 ! respiratory airway
relationship: part_of GO:0060541 ! respiratory system development
relationship: results_in_development_of UBERON:0001005 ! respiratory airway

[Term]
id: GO:0060439
name: trachea morphogenesis
namespace: biological_process
def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001005 ! respiratory airway
relationship: part_of GO:0060438 ! trachea development
relationship: results_in_morphogenesis_of UBERON:0001005 ! respiratory airway

[Term]
id: GO:0060440
name: trachea formation
namespace: biological_process
def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048645 ! animal organ formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001005 ! respiratory airway
relationship: part_of GO:0060439 ! trachea morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001005 ! respiratory airway

[Term]
id: GO:0060441
name: epithelial tube branching involved in lung morphogenesis
namespace: biological_process
def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung]
synonym: "lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: GO:0048754 ! branching morphogenesis of an epithelial tube
intersection_of: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis

[Term]
id: GO:0060450
name: positive regulation of hindgut contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0060456 ! positive regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0043133 ! hindgut contraction
relationship: positively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060451
name: negative regulation of hindgut contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0060457 ! negative regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0043133 ! hindgut contraction
relationship: negatively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060452
name: positive regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060048 ! cardiac muscle contraction
relationship: positively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0060453
name: regulation of gastric acid secretion
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001696 ! gastric acid secretion
relationship: regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060454
name: positive regulation of gastric acid secretion
namespace: biological_process
def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060456 ! positive regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001696 ! gastric acid secretion
relationship: positively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060455
name: negative regulation of gastric acid secretion
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060457 ! negative regulation of digestive system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001696 ! gastric acid secretion
relationship: negatively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060456
name: positive regulation of digestive system process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022600 ! digestive system process
relationship: positively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060457
name: negative regulation of digestive system process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022600 ! digestive system process
relationship: negatively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060458
name: right lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0030324 ! lung development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002167 ! right lung
relationship: results_in_development_of UBERON:0002167 ! right lung

[Term]
id: GO:0060459
name: left lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "left pulmonary development" EXACT [GOC:dph]
is_a: GO:0030324 ! lung development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002168 ! left lung
relationship: results_in_development_of UBERON:0002168 ! left lung

[Term]
id: GO:0060460
name: left lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph]
is_a: GO:0060425 ! lung morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002168 ! left lung
relationship: part_of GO:0060459 ! left lung development
relationship: results_in_morphogenesis_of UBERON:0002168 ! left lung

[Term]
id: GO:0060461
name: right lung morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060425 ! lung morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002167 ! right lung
relationship: part_of GO:0060458 ! right lung development
relationship: results_in_morphogenesis_of UBERON:0002167 ! right lung

[Term]
id: GO:0060462
name: lung lobe development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000101 ! lobe of lung
relationship: part_of GO:0030324 ! lung development
relationship: results_in_development_of UBERON:0000101 ! lobe of lung

[Term]
id: GO:0060463
name: lung lobe morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000101 ! lobe of lung
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060462 ! lung lobe development
relationship: results_in_morphogenesis_of UBERON:0000101 ! lobe of lung

[Term]
id: GO:0060464
name: lung lobe formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000101 ! lobe of lung
relationship: part_of GO:0060463 ! lung lobe morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000101 ! lobe of lung

[Term]
id: GO:0060465
name: pharynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]
synonym: "pharyngeal development" RELATED []
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006562 ! pharynx
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_development_of UBERON:0006562 ! pharynx

[Term]
id: GO:0060467
name: negative regulation of fertilization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009566 ! fertilization
relationship: negatively_regulates GO:0009566 ! fertilization

[Term]
id: GO:0060468
name: prevention of polyspermy
namespace: biological_process
def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph]
synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph]
synonym: "polyspermy block" EXACT [GOC:dph]
is_a: GO:0022414 ! reproductive process
is_a: GO:0060467 ! negative regulation of fertilization
intersection_of: GO:0060467 ! negative regulation of fertilization
intersection_of: part_of GO:0007343 ! egg activation
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060474
name: positive regulation of flagellated sperm motility involved in capacitation
namespace: biological_process
def: "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." [GOC:cilia, GOC:dph, GOC:krc]
synonym: "positive regulation of sperm motility involved in capacitation" RELATED []
is_a: GO:0022414 ! reproductive process
is_a: GO:1902093 ! positive regulation of flagellated sperm motility
intersection_of: GO:1902093 ! positive regulation of flagellated sperm motility
intersection_of: part_of GO:0048240 ! sperm capacitation
relationship: part_of GO:0048240 ! sperm capacitation

[Term]
id: GO:0060479
name: lung cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060485
name: mesenchyme development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]
synonym: "mesenchymal development" EXACT [GOC:dph]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003104 ! mesenchyme
relationship: part_of GO:0048513 ! animal organ development
relationship: results_in_development_of UBERON:0003104 ! mesenchyme

[Term]
id: GO:0060487
name: lung epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]
synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060479 ! lung cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000082 ! epithelial cell of lung
relationship: part_of GO:0060428 ! lung epithelium development
relationship: results_in_acquisition_of_features_of CL:0000082 ! epithelial cell of lung

[Term]
id: GO:0060491
name: regulation of cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb]
synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030031 ! cell projection assembly
relationship: regulates GO:0030031 ! cell projection assembly

[Term]
id: GO:0060495
name: cell-cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung]
synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060496
name: mesenchymal-epithelial cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: GO:0060638 ! mesenchymal-epithelial cell signaling
intersection_of: part_of GO:0030324 ! lung development

[Term]
id: GO:0060497
name: mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph]
synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000223 ! endodermal cell
intersection_of: has_start_location CL:0008019 ! mesenchymal cell
relationship: has_end_location CL:0000223 ! endodermal cell
relationship: has_start_location CL:0008019 ! mesenchymal cell

[Term]
id: GO:0060501
name: positive regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:0060502
name: epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060536
name: cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007844 ! cartilage element
relationship: part_of GO:0051216 ! cartilage development
relationship: results_in_morphogenesis_of UBERON:0007844 ! cartilage element
created_by: dph
creation_date: 2009-04-10T09:13:27Z

[Term]
id: GO:0060537
name: muscle tissue development
namespace: biological_process
def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002385 ! muscle tissue
relationship: results_in_development_of UBERON:0002385 ! muscle tissue
created_by: dph
creation_date: 2009-04-10T08:05:37Z

[Term]
id: GO:0060538
name: skeletal muscle organ development
namespace: biological_process
def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]
is_a: GO:0007517 ! muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0014892 ! skeletal muscle organ, vertebrate
relationship: results_in_development_of UBERON:0014892 ! skeletal muscle organ, vertebrate
created_by: dph
creation_date: 2009-04-10T08:25:12Z

[Term]
id: GO:0060539
name: diaphragm development
namespace: biological_process
def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph]
is_a: GO:0060538 ! skeletal muscle organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001103 ! diaphragm
relationship: part_of GO:0060541 ! respiratory system development
relationship: results_in_development_of UBERON:0001103 ! diaphragm
property_value: RO:0002161 NCBITaxon:8782
created_by: dph
creation_date: 2009-04-10T08:44:56Z

[Term]
id: GO:0060540
name: diaphragm morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph]
is_a: GO:0048644 ! muscle organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001103 ! diaphragm
relationship: part_of GO:0060539 ! diaphragm development
relationship: results_in_morphogenesis_of UBERON:0001103 ! diaphragm
property_value: RO:0002161 NCBITaxon:8782
created_by: dph
creation_date: 2009-04-10T08:47:51Z

[Term]
id: GO:0060541
name: respiratory system development
namespace: biological_process
def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001004 ! respiratory system
relationship: results_in_development_of UBERON:0001004 ! respiratory system
created_by: dph
creation_date: 2009-04-10T08:55:42Z

[Term]
id: GO:0060560
name: developmental growth involved in morphogenesis
namespace: biological_process
def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]
synonym: "differential growth" EXACT [GOC:dph]
is_a: GO:0048589 ! developmental growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
created_by: dph
creation_date: 2009-04-28T08:42:53Z

[Term]
id: GO:0060561
name: apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis]
synonym: "apoptosis involved in development" RELATED []
synonym: "apoptosis involved in morphogenesis" NARROW []
synonym: "morphogenetic apoptosis" RELATED [GOC:dph]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009653 ! anatomical structure morphogenesis
created_by: dph
creation_date: 2009-04-28T09:17:27Z

[Term]
id: GO:0060562
name: epithelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003914 ! epithelial tube
relationship: results_in_morphogenesis_of UBERON:0003914 ! epithelial tube
created_by: dph
creation_date: 2009-04-28T09:33:36Z

[Term]
id: GO:0060563
name: neuroepithelial cell differentiation
namespace: biological_process
def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000710 ! neurecto-epithelial cell
relationship: results_in_acquisition_of_features_of CL:0000710 ! neurecto-epithelial cell
created_by: dph
creation_date: 2009-04-29T01:50:05Z

[Term]
id: GO:0060571
name: morphogenesis of an epithelial fold
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph]
synonym: "epithelial folding" EXACT [GOC:dph]
synonym: "folding of an epithelial sheet" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005157 ! epithelial fold
relationship: results_in_morphogenesis_of UBERON:0005157 ! epithelial fold
created_by: dph
creation_date: 2009-04-30T09:27:17Z

[Term]
id: GO:0060572
name: morphogenesis of an epithelial bud
namespace: biological_process
def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005153 ! epithelial bud
relationship: results_in_morphogenesis_of UBERON:0005153 ! epithelial bud
created_by: dph
creation_date: 2009-04-30T09:38:35Z

[Term]
id: GO:0060574
name: intestinal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0002563 ! intestinal epithelial cell
relationship: part_of GO:0060576 ! intestinal epithelial cell development
relationship: results_in_maturation_of CL:0002563 ! intestinal epithelial cell
created_by: dph
creation_date: 2009-05-06T08:10:41Z

[Term]
id: GO:0060575
name: intestinal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002563 ! intestinal epithelial cell
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_acquisition_of_features_of CL:0002563 ! intestinal epithelial cell
created_by: dph
creation_date: 2009-05-06T08:17:56Z

[Term]
id: GO:0060576
name: intestinal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0002563 ! intestinal epithelial cell
relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation
relationship: results_in_development_of CL:0002563 ! intestinal epithelial cell
created_by: dph
creation_date: 2009-05-06T08:20:24Z

[Term]
id: GO:0060577
name: pulmonary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph]
synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002016 ! pulmonary vein
relationship: results_in_morphogenesis_of UBERON:0002016 ! pulmonary vein
created_by: dph
creation_date: 2009-05-06T08:44:04Z

[Term]
id: GO:0060578
name: superior vena cava morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001585 ! anterior vena cava
relationship: results_in_morphogenesis_of UBERON:0001585 ! anterior vena cava
created_by: dph
creation_date: 2009-05-06T08:47:21Z

[Term]
id: GO:0060581
name: cell fate commitment involved in pattern specification
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: part_of GO:0007389 ! pattern specification process
relationship: part_of GO:0007389 ! pattern specification process
created_by: dph
creation_date: 2009-05-07T12:40:55Z

[Term]
id: GO:0060591
name: chondroblast differentiation
namespace: biological_process
def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph]
synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000058 ! chondroblast
relationship: part_of GO:0051216 ! cartilage development
relationship: results_in_acquisition_of_features_of CL:0000058 ! chondroblast
created_by: dph
creation_date: 2009-05-11T07:47:36Z

[Term]
id: GO:0060612
name: adipose tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph]
synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001013 ! adipose tissue
relationship: part_of GO:0048513 ! animal organ development
relationship: results_in_development_of UBERON:0001013 ! adipose tissue
created_by: dph
creation_date: 2009-05-15T12:36:28Z

[Term]
id: GO:0060623
name: regulation of chromosome condensation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030261 ! chromosome condensation
relationship: regulates GO:0030261 ! chromosome condensation
created_by: dph
creation_date: 2009-05-18T02:12:13Z

[Term]
id: GO:0060627
name: regulation of vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016192 ! vesicle-mediated transport
relationship: regulates GO:0016192 ! vesicle-mediated transport
created_by: dph
creation_date: 2009-05-18T02:29:43Z

[Term]
id: GO:0060632
name: regulation of microtubule-based movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007018 ! microtubule-based movement
relationship: regulates GO:0007018 ! microtubule-based movement
created_by: dph
creation_date: 2009-05-18T03:07:02Z

[Term]
id: GO:0060638
name: mesenchymal-epithelial cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph]
synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000066 ! epithelial cell
intersection_of: has_start_location CL:0008019 ! mesenchymal cell
relationship: has_end_location CL:0000066 ! epithelial cell
relationship: has_start_location CL:0008019 ! mesenchymal cell
created_by: dph
creation_date: 2009-05-19T03:59:05Z

[Term]
id: GO:0060669
name: embryonic placenta morphogenesis
namespace: biological_process
def: "The process in which the embryonic placenta is generated and organized." [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007106 ! chorionic villus
relationship: part_of GO:0001892 ! embryonic placenta development
relationship: results_in_morphogenesis_of UBERON:0007106 ! chorionic villus
created_by: dph
creation_date: 2009-06-02T09:33:37Z

[Term]
id: GO:0060670
name: branching involved in labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0060713 ! labyrinthine layer morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis
created_by: dph
creation_date: 2009-06-02T10:40:40Z

[Term]
id: GO:0060671
name: epithelial cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
intersection_of: GO:0030855 ! epithelial cell differentiation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development
created_by: dph
creation_date: 2009-06-02T11:40:52Z

[Term]
id: GO:0060673
name: cell-cell signaling involved in placenta development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377]
synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001890 ! placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-02T12:58:03Z

[Term]
id: GO:0060674
name: placenta blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0001890 ! placenta development
created_by: dph
creation_date: 2009-06-02T01:09:43Z

[Term]
id: GO:0060675
name: ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000084 ! ureteric bud
relationship: part_of GO:0001657 ! ureteric bud development
relationship: results_in_morphogenesis_of UBERON:0000084 ! ureteric bud
created_by: dph
creation_date: 2009-06-02T01:31:41Z

[Term]
id: GO:0060676
name: ureteric bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378]
is_a: GO:0072172 ! mesonephric tubule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000084 ! ureteric bud
relationship: part_of GO:0060675 ! ureteric bud morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000084 ! ureteric bud
created_by: dph
creation_date: 2009-06-02T01:47:23Z

[Term]
id: GO:0060684
name: epithelial-mesenchymal cell signaling
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0008019 ! mesenchymal cell
intersection_of: has_start_location CL:0000066 ! epithelial cell
relationship: has_end_location CL:0008019 ! mesenchymal cell
relationship: has_start_location CL:0000066 ! epithelial cell
created_by: dph
creation_date: 2009-06-03T06:36:46Z

[Term]
id: GO:0060688
name: regulation of morphogenesis of a branching structure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001763 ! morphogenesis of a branching structure
relationship: regulates GO:0001763 ! morphogenesis of a branching structure
created_by: dph
creation_date: 2009-06-05T12:41:44Z

[Term]
id: GO:0060706
name: cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-09T10:26:42Z

[Term]
id: GO:0060711
name: labyrinthine layer development
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003946 ! placenta labyrinth
relationship: part_of GO:0001892 ! embryonic placenta development
relationship: results_in_development_of UBERON:0003946 ! placenta labyrinth
created_by: dph
creation_date: 2009-06-09T03:27:43Z

[Term]
id: GO:0060713
name: labyrinthine layer morphogenesis
namespace: biological_process
def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003946 ! placenta labyrinth
relationship: part_of GO:0060669 ! embryonic placenta morphogenesis
relationship: part_of GO:0060711 ! labyrinthine layer development
relationship: results_in_morphogenesis_of UBERON:0003946 ! placenta labyrinth
created_by: dph
creation_date: 2009-06-10T08:10:19Z

[Term]
id: GO:0060714
name: labyrinthine layer formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003946 ! placenta labyrinth
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003946 ! placenta labyrinth
created_by: dph
creation_date: 2009-06-10T08:13:14Z

[Term]
id: GO:0060716
name: labyrinthine layer blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
is_a: GO:0060674 ! placenta blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004183 ! placental labyrinth blood vessel
relationship: part_of GO:0060711 ! labyrinthine layer development
relationship: results_in_development_of UBERON:0004183 ! placental labyrinth blood vessel
created_by: dph
creation_date: 2009-06-11T09:04:38Z

[Term]
id: GO:0060717
name: chorion development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph]
is_a: GO:1903867 ! extraembryonic membrane development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003124 ! chorion membrane
relationship: results_in_development_of UBERON:0003124 ! chorion membrane
created_by: dph
creation_date: 2009-06-11T02:37:50Z

[Term]
id: GO:0060718
name: chorionic trophoblast cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0011101 ! chorionic trophoblast cell
relationship: part_of GO:0060717 ! chorion development
relationship: results_in_acquisition_of_features_of CL:0011101 ! chorionic trophoblast cell
created_by: dph
creation_date: 2009-06-11T02:48:27Z

[Term]
id: GO:0060719
name: chorionic trophoblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph]
is_a: GO:0048468 ! cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0011101 ! chorionic trophoblast cell
relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation
relationship: results_in_development_of CL:0011101 ! chorionic trophoblast cell
created_by: dph
creation_date: 2009-06-11T02:58:45Z

[Term]
id: GO:0060722
name: cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0001892 ! embryonic placenta development
relationship: part_of GO:0001892 ! embryonic placenta development
created_by: dph
creation_date: 2009-06-12T12:46:04Z

[Term]
id: GO:0060723
name: regulation of cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development
relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development
created_by: dph
creation_date: 2009-06-12T12:50:23Z

[Term]
id: GO:0060788
name: ectodermal placode formation
namespace: biological_process
def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005085 ! ectodermal placode
relationship: part_of GO:0071697 ! ectodermal placode morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005085 ! ectodermal placode
created_by: dph
creation_date: 2009-08-04T12:15:57Z

[Term]
id: GO:0060795
name: cell fate commitment involved in formation of primary germ layer
namespace: biological_process
def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
intersection_of: GO:0045165 ! cell fate commitment
intersection_of: part_of GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0001704 ! formation of primary germ layer
created_by: dph
creation_date: 2009-08-04T03:11:22Z

[Term]
id: GO:0060800
name: regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T01:20:25Z

[Term]
id: GO:0060806
name: negative regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development
created_by: dph
creation_date: 2009-08-06T02:02:18Z

[Term]
id: GO:0060815
name: regulation of translation involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0006417 ! regulation of translation
intersection_of: part_of GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0009948 ! anterior/posterior axis specification
created_by: dph
creation_date: 2009-08-07T10:02:31Z

[Term]
id: GO:0060837
name: blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000071 ! blood vessel endothelial cell
relationship: part_of GO:0001568 ! blood vessel development
relationship: results_in_acquisition_of_features_of CL:0000071 ! blood vessel endothelial cell
created_by: dph
creation_date: 2009-08-11T03:47:36Z

[Term]
id: GO:0060840
name: artery development
namespace: biological_process
def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001637 ! artery
relationship: results_in_development_of UBERON:0001637 ! artery
created_by: dph
creation_date: 2009-08-12T10:10:51Z

[Term]
id: GO:0060841
name: venous blood vessel development
namespace: biological_process
def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001638 ! vein
relationship: results_in_development_of UBERON:0001638 ! vein
created_by: dph
creation_date: 2009-08-12T10:14:07Z

[Term]
id: GO:0060842
name: arterial endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000413 ! endothelial cell of artery
relationship: results_in_acquisition_of_features_of CL:1000413 ! endothelial cell of artery
created_by: dph
creation_date: 2009-08-12T10:41:34Z

[Term]
id: GO:0060843
name: venous endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002543 ! vein endothelial cell
relationship: results_in_acquisition_of_features_of CL:0002543 ! vein endothelial cell
created_by: dph
creation_date: 2009-08-12T10:43:40Z

[Term]
id: GO:0060896
name: neural plate pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process
created_by: dph
creation_date: 2009-08-13T02:06:27Z

[Term]
id: GO:0060897
name: neural plate regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060896 ! neural plate pattern specification
created_by: dph
creation_date: 2009-08-13T02:09:04Z

[Term]
id: GO:0060900
name: embryonic camera-type eye formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis
created_by: dph
creation_date: 2009-08-13T02:26:54Z

[Term]
id: GO:0060914
name: heart formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "cardiogenesis" RELATED [GOC:mtg_heart]
is_a: GO:0048645 ! animal organ formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000948 ! heart
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000948 ! heart
created_by: dph
creation_date: 2009-09-17T09:02:13Z

[Term]
id: GO:0060915
name: mesenchymal cell differentiation involved in lung development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2009-09-18T11:45:33Z

[Term]
id: GO:0060916
name: mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph]
is_a: GO:0010463 ! mesenchymal cell proliferation
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0030324 ! lung development
relationship: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2009-09-18T11:50:17Z

[Term]
id: GO:0060920
name: cardiac pacemaker cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell differentiation" BROAD []
is_a: GO:0055007 ! cardiac muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002072 ! nodal myocyte
relationship: results_in_acquisition_of_features_of CL:0002072 ! nodal myocyte
created_by: dph
creation_date: 2009-09-29T11:01:31Z

[Term]
id: GO:0060921
name: sinoatrial node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart]
synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000409 ! myocyte of sinoatrial node
relationship: part_of GO:0003163 ! sinoatrial node development
relationship: results_in_acquisition_of_features_of CL:1000409 ! myocyte of sinoatrial node
created_by: dph
creation_date: 2009-09-29T11:03:30Z

[Term]
id: GO:0060922
name: atrioventricular node cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart]
synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart]
is_a: GO:0003292 ! cardiac septum cell differentiation
is_a: GO:0060920 ! cardiac pacemaker cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000410 ! myocyte of atrioventricular node
relationship: part_of GO:0003162 ! atrioventricular node development
relationship: results_in_acquisition_of_features_of CL:1000410 ! myocyte of atrioventricular node
created_by: dph
creation_date: 2009-09-29T11:07:06Z

[Term]
id: GO:0060926
name: cardiac pacemaker cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]
synonym: "pacemaker cell development" BROAD []
is_a: GO:0055013 ! cardiac muscle cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0002072 ! nodal myocyte
relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation
relationship: results_in_development_of CL:0002072 ! nodal myocyte
created_by: dph
creation_date: 2009-09-29T11:51:55Z

[Term]
id: GO:0060928
name: atrioventricular node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "AV node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! cardiac pacemaker cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:1000410 ! myocyte of atrioventricular node
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation
relationship: results_in_development_of CL:1000410 ! myocyte of atrioventricular node
created_by: dph
creation_date: 2009-09-29T11:59:26Z

[Term]
id: GO:0060931
name: sinoatrial node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell development" EXACT [GOC:mtg_heart]
synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0060926 ! cardiac pacemaker cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:1000409 ! myocyte of sinoatrial node
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation
relationship: results_in_development_of CL:1000409 ! myocyte of sinoatrial node
created_by: dph
creation_date: 2009-09-29T12:05:47Z

[Term]
id: GO:0060932
name: His-Purkinje system cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010007 ! His-Purkinje system cell
relationship: part_of GO:0003164 ! His-Purkinje system development
relationship: results_in_acquisition_of_features_of CL:0010007 ! His-Purkinje system cell
created_by: dph
creation_date: 2009-09-29T01:10:32Z

[Term]
id: GO:0060933
name: His-Purkinje system cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0010007 ! His-Purkinje system cell
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation
relationship: results_in_development_of CL:0010007 ! His-Purkinje system cell
created_by: dph
creation_date: 2009-09-29T01:15:02Z

[Term]
id: GO:0060935
name: cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002548 ! fibroblast of cardiac tissue
relationship: results_in_acquisition_of_features_of CL:0002548 ! fibroblast of cardiac tissue
created_by: dph
creation_date: 2009-09-29T01:20:04Z

[Term]
id: GO:0060936
name: cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0002548 ! fibroblast of cardiac tissue
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation
relationship: results_in_development_of CL:0002548 ! fibroblast of cardiac tissue
created_by: dph
creation_date: 2009-09-29T01:23:03Z

[Term]
id: GO:0060945
name: cardiac neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010022 ! cardiac neuron
relationship: part_of GO:0048483 ! autonomic nervous system development
relationship: results_in_acquisition_of_features_of CL:0010022 ! cardiac neuron
created_by: dph
creation_date: 2009-09-29T02:45:33Z

[Term]
id: GO:0060946
name: cardiac blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0060837 ! blood vessel endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010006 ! cardiac blood vessel endothelial cell
relationship: results_in_acquisition_of_features_of CL:0010006 ! cardiac blood vessel endothelial cell
created_by: dph
creation_date: 2009-09-29T02:48:55Z

[Term]
id: GO:0060950
name: cardiac glial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0010020 ! cardiac glial cell
relationship: results_in_acquisition_of_features_of CL:0010020 ! cardiac glial cell
created_by: dph
creation_date: 2009-09-29T03:06:37Z

[Term]
id: GO:0060952
name: cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0010020 ! cardiac glial cell
relationship: part_of GO:0060950 ! cardiac glial cell differentiation
relationship: results_in_development_of CL:0010020 ! cardiac glial cell
created_by: dph
creation_date: 2009-09-29T03:09:24Z

[Term]
id: GO:0060956
name: endocardial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002350 ! endocardial cell
relationship: part_of GO:0003157 ! endocardium development
relationship: results_in_acquisition_of_features_of CL:0002350 ! endocardial cell
created_by: dph
creation_date: 2009-09-29T03:20:39Z

[Term]
id: GO:0060958
name: endocardial cell development
namespace: biological_process
def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0001885 ! endothelial cell development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0002350 ! endocardial cell
relationship: part_of GO:0060956 ! endocardial cell differentiation
relationship: results_in_development_of CL:0002350 ! endocardial cell
created_by: dph
creation_date: 2009-09-29T03:26:59Z

[Term]
id: GO:0060959
name: cardiac neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart neuron development" EXACT [GOC:mtg_heart]
is_a: GO:0048666 ! neuron development
is_a: GO:0055006 ! cardiac cell development
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0010022 ! cardiac neuron
relationship: part_of GO:0060945 ! cardiac neuron differentiation
relationship: results_in_development_of CL:0010022 ! cardiac neuron
created_by: dph
creation_date: 2009-09-30T10:14:56Z

[Term]
id: GO:0060973
name: cell migration involved in heart development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-06T10:53:49Z

[Term]
id: GO:0060974
name: cell migration involved in heart formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-06T10:56:33Z

[Term]
id: GO:0060976
name: coronary vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart vasculature development" EXACT [GOC:mtg_heart]
is_a: GO:0001568 ! blood vessel development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003498 ! heart blood vessel
relationship: part_of GO:0007507 ! heart development
relationship: results_in_development_of UBERON:0003498 ! heart blood vessel
created_by: dph
creation_date: 2009-10-06T12:15:23Z

[Term]
id: GO:0060977
name: coronary vasculature morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart]
synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003498 ! heart blood vessel
relationship: part_of GO:0060976 ! coronary vasculature development
relationship: results_in_morphogenesis_of UBERON:0003498 ! heart blood vessel
created_by: dph
creation_date: 2009-10-06T12:28:23Z

[Term]
id: GO:0060978
name: angiogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart]
synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001525 ! angiogenesis
intersection_of: GO:0001525 ! angiogenesis
intersection_of: part_of GO:0060976 ! coronary vasculature development
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-06T02:02:12Z

[Term]
id: GO:0060979
name: vasculogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart]
synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart]
synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001570 ! vasculogenesis
intersection_of: GO:0001570 ! vasculogenesis
intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-06T02:19:42Z

[Term]
id: GO:0060980
name: cell migration involved in coronary vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart]
is_a: GO:0035441 ! cell migration involved in vasculogenesis
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis
relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis
created_by: dph
creation_date: 2009-10-06T02:33:06Z

[Term]
id: GO:0060981
name: cell migration involved in coronary angiogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis
relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis
created_by: dph
creation_date: 2009-10-06T02:49:12Z

[Term]
id: GO:0060986
name: endocrine hormone secretion
namespace: biological_process
def: "The regulated release of a hormone into the circulatory system." [GOC:dph]
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0050886 ! endocrine process
created_by: dph
creation_date: 2010-01-11T09:03:48Z

[Term]
id: GO:0060993
name: kidney morphogenesis
namespace: biological_process
def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002113 ! kidney
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_morphogenesis_of UBERON:0002113 ! kidney
created_by: dph
creation_date: 2010-01-19T08:16:55Z

[Term]
id: GO:0060995
name: cell-cell signaling involved in kidney development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-19T08:33:40Z

[Term]
id: GO:0061004
name: pattern specification involved in kidney development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10]
synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
relationship: part_of GO:0072048 ! renal system pattern specification
created_by: dph
creation_date: 2010-01-21T09:05:54Z

[Term]
id: GO:0061005
name: cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: dph
creation_date: 2010-01-21T09:13:55Z

[Term]
id: GO:0061006
name: regulation of cell proliferation involved in kidney morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0042127 ! regulation of cell population proliferation
intersection_of: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis
created_by: dph
creation_date: 2010-01-21T11:25:23Z

[Term]
id: GO:0061007
name: hepaticobiliary system process
namespace: biological_process
def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
subset: goslim_generic
synonym: "hepatobiliary system process" EXACT [GOC:dph]
is_a: GO:0003008 ! system process
created_by: dph
creation_date: 2010-01-22T09:09:10Z

[Term]
id: GO:0061008
name: hepaticobiliary system development
namespace: biological_process
def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system development" EXACT [GOC:dph]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002423 ! hepatobiliary system
relationship: results_in_development_of UBERON:0002423 ! hepatobiliary system
created_by: dph
creation_date: 2010-01-22T09:11:59Z

[Term]
id: GO:0061009
name: common bile duct development
namespace: biological_process
def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine." [PMID:20614624]
synonym: "bile duct development" EXACT [GOC:dph]
synonym: "CBD development" EXACT [PMID:20614624]
synonym: "EHBD development" BROAD [PMID:20614624]
synonym: "extrahepatic bile duct development" BROAD [PMID:20614624]
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002394 ! bile duct
relationship: part_of GO:0061008 ! hepaticobiliary system development
relationship: results_in_development_of UBERON:0002394 ! bile duct
created_by: dph
creation_date: 2010-01-22T09:17:13Z

[Term]
id: GO:0061010
name: gallbladder development
namespace: biological_process
def: "The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002110 ! gallbladder
relationship: part_of GO:0061008 ! hepaticobiliary system development
relationship: results_in_development_of UBERON:0002110 ! gallbladder
created_by: dph
creation_date: 2010-01-22T09:38:44Z

[Term]
id: GO:0061011
name: hepatic duct development
namespace: biological_process
def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624]
is_a: GO:0061009 ! common bile duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001175 ! common hepatic duct
relationship: results_in_development_of UBERON:0001175 ! common hepatic duct
created_by: dph
creation_date: 2010-01-22T09:44:39Z

[Term]
id: GO:0061017
name: hepatoblast differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0048863 ! stem cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000488 ! cholangiocyte
relationship: part_of GO:0001889 ! liver development
relationship: results_in_acquisition_of_features_of CL:1000488 ! cholangiocyte
created_by: dph
creation_date: 2010-02-02T09:08:03Z

[Term]
id: GO:0061024
name: membrane organization
namespace: biological_process
alt_id: GO:0016044
alt_id: GO:0044802
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular membrane organisation" EXACT []
synonym: "cellular membrane organization" EXACT []
synonym: "membrane organisation" EXACT [GOC:mah]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "single-organism membrane organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0016020 ! membrane
relationship: results_in_organization_of GO:0016020 ! membrane
created_by: jl
creation_date: 2010-02-08T02:43:11Z

[Term]
id: GO:0061025
name: membrane fusion
namespace: biological_process
alt_id: GO:0006944
alt_id: GO:0044801
def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
subset: goslim_yeast
synonym: "cellular membrane fusion" EXACT []
synonym: "single-organism membrane fusion" RELATED []
xref: Wikipedia:Lipid_bilayer_fusion
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0061024 ! membrane organization
intersection_of: results_in_fusion_of GO:0016020 ! membrane
relationship: results_in_fusion_of GO:0016020 ! membrane
created_by: jl
creation_date: 2010-02-08T02:48:06Z

[Term]
id: GO:0061027
name: umbilical cord development
namespace: biological_process
def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002331 ! umbilical cord
relationship: results_in_development_of UBERON:0002331 ! umbilical cord
created_by: dph
creation_date: 2010-02-09T09:09:22Z

[Term]
id: GO:0061032
name: visceral serous pericardium development
namespace: biological_process
def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf]
synonym: "epicardium development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002425 ! visceral serous pericardium
relationship: part_of GO:0060039 ! pericardium development
relationship: results_in_development_of UBERON:0002425 ! visceral serous pericardium
created_by: dph
creation_date: 2010-02-09T09:52:49Z

[Term]
id: GO:0061035
name: regulation of cartilage development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051216 ! cartilage development
relationship: regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061036
name: positive regulation of cartilage development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051216 ! cartilage development
relationship: positively_regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061037
name: negative regulation of cartilage development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061035 ! regulation of cartilage development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051216 ! cartilage development
relationship: negatively_regulates GO:0051216 ! cartilage development
created_by: dph
creation_date: 2010-02-09T03:41:35Z

[Term]
id: GO:0061038
name: uterus morphogenesis
namespace: biological_process
def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000995 ! uterus
relationship: part_of GO:0060065 ! uterus development
relationship: results_in_morphogenesis_of UBERON:0000995 ! uterus
created_by: dph
creation_date: 2010-02-22T11:12:35Z

[Term]
id: GO:0061040
name: female gonad morphogenesis
namespace: biological_process
def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph]
synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0035262 ! gonad morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000992 ! ovary
relationship: part_of GO:0008585 ! female gonad development
relationship: results_in_morphogenesis_of UBERON:0000992 ! ovary
created_by: dph
creation_date: 2010-02-22T11:29:28Z

[Term]
id: GO:0061046
name: regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:41:38Z

[Term]
id: GO:0061047
name: positive regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:50:01Z

[Term]
id: GO:0061048
name: negative regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis
created_by: dph
creation_date: 2010-02-25T10:51:31Z

[Term]
id: GO:0061049
name: cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph]
synonym: "cardiomyocyte growth" RELATED [GOC:dph]
synonym: "heart muscle cell growth" RELATED [GOC:dph]
is_a: GO:0048588 ! developmental cell growth
intersection_of: GO:0016049 ! cell growth
intersection_of: part_of GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy
relationship: part_of GO:0055013 ! cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T12:56:07Z

[Term]
id: GO:0061050
name: regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:05:16Z

[Term]
id: GO:0061051
name: positive regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:08:08Z

[Term]
id: GO:0061052
name: negative regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development
created_by: dph
creation_date: 2010-02-25T01:11:30Z

[Term]
id: GO:0061053
name: somite development
namespace: biological_process
def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002329 ! somite
relationship: part_of GO:0009790 ! embryo development
relationship: results_in_development_of UBERON:0002329 ! somite
created_by: dph
creation_date: 2010-03-02T12:05:13Z

[Term]
id: GO:0061054
name: dermatome development
namespace: biological_process
def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004016 ! dermatome
relationship: part_of GO:0061053 ! somite development
relationship: results_in_development_of UBERON:0004016 ! dermatome
created_by: dph
creation_date: 2010-03-02T12:07:37Z

[Term]
id: GO:0061055
name: myotome development
namespace: biological_process
def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003082 ! myotome
relationship: part_of GO:0061053 ! somite development
relationship: results_in_development_of UBERON:0003082 ! myotome
created_by: dph
creation_date: 2010-03-02T12:11:01Z

[Term]
id: GO:0061056
name: sclerotome development
namespace: biological_process
def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003089 ! sclerotome
relationship: part_of GO:0061053 ! somite development
relationship: results_in_development_of UBERON:0003089 ! sclerotome
created_by: dph
creation_date: 2010-03-02T12:12:40Z

[Term]
id: GO:0061061
name: muscle structure development
namespace: biological_process
def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]
subset: goslim_drosophila
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005090 ! muscle structure
relationship: in_taxon NCBITaxon:6072 {all_only="true"} ! Eumetazoa
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: results_in_development_of UBERON:0005090 ! muscle structure
created_by: dph
creation_date: 2010-03-09T08:55:14Z

[Term]
id: GO:0061062
name: regulation of nematode larval development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048580 ! regulation of post-embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002119 ! nematode larval development
relationship: regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T12:59:21Z

[Term]
id: GO:0061063
name: positive regulation of nematode larval development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002119 ! nematode larval development
relationship: positively_regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T01:03:34Z

[Term]
id: GO:0061064
name: negative regulation of nematode larval development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv]
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0061062 ! regulation of nematode larval development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002119 ! nematode larval development
relationship: negatively_regulates GO:0002119 ! nematode larval development
created_by: dph
creation_date: 2010-03-11T01:04:39Z

[Term]
id: GO:0061068
name: urethra development
namespace: biological_process
def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph]
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000057 ! urethra
relationship: part_of GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0000057 ! urethra
created_by: dph
creation_date: 2010-03-12T08:24:52Z

[Term]
id: GO:0061069
name: male urethra development
namespace: biological_process
def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph]
is_a: GO:0061068 ! urethra development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001333 ! male urethra
relationship: results_in_development_of UBERON:0001333 ! male urethra
created_by: dph
creation_date: 2010-03-12T08:28:19Z

[Term]
id: GO:0061070
name: female urethra development
namespace: biological_process
def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph]
is_a: GO:0061068 ! urethra development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001334 ! female urethra
relationship: results_in_development_of UBERON:0001334 ! female urethra
created_by: dph
creation_date: 2010-03-12T08:29:43Z

[Term]
id: GO:0061071
name: urethra epithelium development
namespace: biological_process
def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002325 ! epithelium of urethra
relationship: part_of GO:0061068 ! urethra development
relationship: results_in_development_of UBERON:0002325 ! epithelium of urethra
created_by: dph
creation_date: 2010-03-12T08:36:53Z

[Term]
id: GO:0061072
name: iris morphogenesis
namespace: biological_process
def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001769 ! iris
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001769 ! iris
created_by: dph
creation_date: 2010-03-16T10:48:42Z

[Term]
id: GO:0061073
name: ciliary body morphogenesis
namespace: biological_process
def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001775 ! ciliary body
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001775 ! ciliary body
created_by: dph
creation_date: 2010-03-16T10:55:19Z

[Term]
id: GO:0061074
name: regulation of neural retina development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003407 ! neural retina development
relationship: regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T11:47:05Z

[Term]
id: GO:0061075
name: positive regulation of neural retina development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902868 ! positive regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003407 ! neural retina development
relationship: positively_regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T11:59:48Z

[Term]
id: GO:0061076
name: negative regulation of neural retina development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph]
is_a: GO:0061074 ! regulation of neural retina development
is_a: GO:1902867 ! negative regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003407 ! neural retina development
relationship: negatively_regulates GO:0003407 ! neural retina development
created_by: dph
creation_date: 2010-03-16T12:46:11Z

[Term]
id: GO:0061080
name: right horn of sinus venosus development
namespace: biological_process
def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005092 ! right horn of sinus venosus
relationship: part_of GO:0003235 ! sinus venosus development
relationship: results_in_development_of UBERON:0005092 ! right horn of sinus venosus
created_by: dph
creation_date: 2010-04-08T02:45:10Z

[Term]
id: GO:0061100
name: lung neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746]
is_a: GO:0061101 ! neuroendocrine cell differentiation
is_a: GO:0061140 ! lung secretory cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000223 ! lung neuroendocrine cell
relationship: results_in_acquisition_of_features_of CL:1000223 ! lung neuroendocrine cell
created_by: dph
creation_date: 2010-04-27T03:28:46Z

[Term]
id: GO:0061101
name: neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060563 ! neuroepithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000165 ! neuroendocrine cell
relationship: results_in_acquisition_of_features_of CL:0000165 ! neuroendocrine cell
created_by: dph
creation_date: 2010-04-28T09:42:20Z

[Term]
id: GO:0061102
name: stomach neuroendocrine cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746]
synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph]
is_a: GO:0035883 ! enteroendocrine cell differentiation
is_a: GO:0061101 ! neuroendocrine cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000222 ! stomach neuroendocrine cell
relationship: part_of GO:0062094 ! stomach development
relationship: results_in_acquisition_of_features_of CL:1000222 ! stomach neuroendocrine cell
created_by: dph
creation_date: 2010-04-28T09:47:07Z

[Term]
id: GO:0061105
name: regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061102 ! stomach neuroendocrine cell differentiation
relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation
created_by: dph
creation_date: 2010-04-29T12:19:37Z

[Term]
id: GO:0061106
name: negative regulation of stomach neuroendocrine cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph]
is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation
relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation
created_by: dph
creation_date: 2010-04-29T12:23:05Z

[Term]
id: GO:0061107
name: seminal vesicle development
namespace: biological_process
def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph]
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000998 ! seminal vesicle
relationship: results_in_development_of UBERON:0000998 ! seminal vesicle
created_by: dph
creation_date: 2010-04-30T10:17:30Z

[Term]
id: GO:0061108
name: seminal vesicle epithelium development
namespace: biological_process
def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004805 ! seminal vesicle epithelium
relationship: part_of GO:0061107 ! seminal vesicle development
relationship: results_in_development_of UBERON:0004805 ! seminal vesicle epithelium
created_by: dph
creation_date: 2010-04-30T10:19:54Z

[Term]
id: GO:0061109
name: dense core granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph]
synonym: "dense core granule organisation" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0031045 ! dense core granule
relationship: results_in_organization_of GO:0031045 ! dense core granule
created_by: dph
creation_date: 2010-05-01T09:34:37Z

[Term]
id: GO:0061111
name: epithelial-mesenchymal cell signaling involved in lung development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph]
synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: GO:0060684 ! epithelial-mesenchymal cell signaling
intersection_of: part_of GO:0030324 ! lung development
created_by: dph
creation_date: 2010-05-05T11:14:38Z

[Term]
id: GO:0061113
name: pancreas morphogenesis
namespace: biological_process
def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001264 ! pancreas
relationship: part_of GO:0031016 ! pancreas development
relationship: results_in_morphogenesis_of UBERON:0001264 ! pancreas
created_by: dph
creation_date: 2010-05-05T11:55:30Z

[Term]
id: GO:0061114
name: branching involved in pancreas morphogenesis
namespace: biological_process
def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph]
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0061113 ! pancreas morphogenesis
relationship: part_of GO:0061113 ! pancreas morphogenesis
created_by: dph
creation_date: 2010-05-05T12:03:04Z

[Term]
id: GO:0061117
name: negative regulation of heart growth
namespace: biological_process
def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd]
is_a: GO:0046621 ! negative regulation of organ growth
is_a: GO:0060420 ! regulation of heart growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060419 ! heart growth
relationship: negatively_regulates GO:0060419 ! heart growth
created_by: dph
creation_date: 2010-05-17T07:31:28Z

[Term]
id: GO:0061130
name: pancreatic bud formation
namespace: biological_process
def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph]
is_a: GO:0048645 ! animal organ formation
is_a: GO:0061114 ! branching involved in pancreas morphogenesis
is_a: GO:0072175 ! epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003922 ! pancreatic epithelial bud
relationship: results_in_formation_of_anatomical_entity UBERON:0003922 ! pancreatic epithelial bud
created_by: dph
creation_date: 2010-05-17T09:33:40Z

[Term]
id: GO:0061138
name: morphogenesis of a branching epithelium
namespace: biological_process
def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0002009 ! morphogenesis of an epithelium
created_by: dph
creation_date: 2010-05-25T09:05:34Z

[Term]
id: GO:0061140
name: lung secretory cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph]
is_a: GO:0060487 ! lung epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000272 ! lung secretory cell
relationship: results_in_acquisition_of_features_of CL:1000272 ! lung secretory cell
created_by: dph
creation_date: 2010-05-25T09:28:53Z

[Term]
id: GO:0061141
name: lung ciliated cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells." [GOC:cilia, GOC:dph, GOC:krc]
is_a: GO:0060487 ! lung epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000271 ! lung ciliated cell
relationship: results_in_acquisition_of_features_of CL:1000271 ! lung ciliated cell
created_by: dph
creation_date: 2010-05-25T09:31:14Z

[Term]
id: GO:0061147
name: endocardial endothelium development
namespace: biological_process
def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
is_a: GO:0003158 ! endothelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005316 ! endocardial endothelium
relationship: part_of GO:0003157 ! endocardium development
relationship: results_in_development_of UBERON:0005316 ! endocardial endothelium
created_by: dph
creation_date: 2010-06-03T09:15:31Z

[Term]
id: GO:0061148
name: extracellular matrix organization involved in endocardium development
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph]
synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0030198 ! extracellular matrix organization
intersection_of: part_of GO:0003157 ! endocardium development
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2010-06-03T09:18:02Z

[Term]
id: GO:0061154
name: endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf]
is_a: GO:0003159 ! morphogenesis of an endothelium
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003915 ! endothelial tube
relationship: results_in_morphogenesis_of UBERON:0003915 ! endothelial tube
created_by: dph
creation_date: 2010-06-15T09:05:00Z

[Term]
id: GO:0061155
name: pulmonary artery endothelial tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf]
is_a: GO:0061154 ! endothelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005317 ! pulmonary artery endothelium
relationship: part_of GO:0061156 ! pulmonary artery morphogenesis
relationship: results_in_morphogenesis_of UBERON:0005317 ! pulmonary artery endothelium
created_by: dph
creation_date: 2010-06-15T09:09:04Z

[Term]
id: GO:0061156
name: pulmonary artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002012 ! pulmonary artery
relationship: results_in_morphogenesis_of UBERON:0002012 ! pulmonary artery
created_by: dph
creation_date: 2010-06-15T09:13:47Z

[Term]
id: GO:0061181
name: regulation of chondrocyte development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002063 ! chondrocyte development
relationship: regulates GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2010-07-14T08:28:52Z

[Term]
id: GO:0061182
name: negative regulation of chondrocyte development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0032331 ! negative regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002063 ! chondrocyte development
relationship: negatively_regulates GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2010-07-14T08:33:05Z

[Term]
id: GO:0061183
name: regulation of dermatome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061054 ! dermatome development
relationship: regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:40:26Z

[Term]
id: GO:0061184
name: positive regulation of dermatome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0040019 ! positive regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061054 ! dermatome development
relationship: positively_regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:42:03Z

[Term]
id: GO:0061185
name: negative regulation of dermatome development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph]
is_a: GO:0045992 ! negative regulation of embryonic development
is_a: GO:0061183 ! regulation of dermatome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061054 ! dermatome development
relationship: negatively_regulates GO:0061054 ! dermatome development
created_by: dph
creation_date: 2010-07-14T08:43:08Z

[Term]
id: GO:0061189
name: positive regulation of sclerotome development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061190 ! regulation of sclerotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061056 ! sclerotome development
relationship: positively_regulates GO:0061056 ! sclerotome development
created_by: dph
creation_date: 2010-07-14T09:17:23Z

[Term]
id: GO:0061190
name: regulation of sclerotome development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061056 ! sclerotome development
relationship: regulates GO:0061056 ! sclerotome development
created_by: dph
creation_date: 2010-07-14T09:19:47Z

[Term]
id: GO:0061205
name: paramesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf]
synonym: "Mullerian duct development" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003890 ! Mullerian duct
relationship: results_in_development_of UBERON:0003890 ! Mullerian duct
created_by: dph
creation_date: 2010-07-30T10:54:47Z

[Term]
id: GO:0061206
name: mesonephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10]
synonym: "Wolffian body morphogenesis" EXACT [GOC:dph]
is_a: GO:0060993 ! kidney morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000080 ! mesonephros
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_morphogenesis_of UBERON:0000080 ! mesonephros
created_by: dph
creation_date: 2010-08-17T03:11:10Z

[Term]
id: GO:0061208
name: cell differentiation involved in mesonephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:21:23Z

[Term]
id: GO:0061209
name: cell proliferation involved in mesonephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:22:46Z

[Term]
id: GO:0061210
name: cell-cell signaling involved in mesonephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:24:08Z

[Term]
id: GO:0061211
name: mesonephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005319 ! mesonephric collecting duct
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0005319 ! mesonephric collecting duct
created_by: dph
creation_date: 2010-08-17T03:25:51Z

[Term]
id: GO:0061213
name: positive regulation of mesonephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090184 ! positive regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001823 ! mesonephros development
relationship: positively_regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:39:35Z

[Term]
id: GO:0061214
name: mesonephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005321 ! mesonephric smooth muscle tissue
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0005321 ! mesonephric smooth muscle tissue
created_by: dph
creation_date: 2010-08-17T03:29:54Z

[Term]
id: GO:0061215
name: mesonephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005322 ! mesonephric nephron
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0005322 ! mesonephric nephron
created_by: dph
creation_date: 2010-08-17T03:31:08Z

[Term]
id: GO:0061217
name: regulation of mesonephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001823 ! mesonephros development
relationship: regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:35:31Z

[Term]
id: GO:0061218
name: negative regulation of mesonephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:0090185 ! negative regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001823 ! mesonephros development
relationship: negatively_regulates GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-17T03:43:06Z

[Term]
id: GO:0061219
name: mesonephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005323 ! mesonephric mesenchyme
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0005323 ! mesonephric mesenchyme
created_by: dph
creation_date: 2010-08-17T03:45:44Z

[Term]
id: GO:0061221
name: mesonephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005323 ! mesonephric mesenchyme
relationship: part_of GO:0061219 ! mesonephric mesenchyme development
relationship: results_in_morphogenesis_of UBERON:0005323 ! mesonephric mesenchyme
created_by: dph
creation_date: 2010-08-19T01:17:38Z

[Term]
id: GO:0061227
name: pattern specification involved in mesonephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001823 ! mesonephros development
relationship: part_of GO:0001823 ! mesonephros development
created_by: dph
creation_date: 2010-08-19T02:22:22Z

[Term]
id: GO:0061228
name: mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005322 ! mesonephric nephron
relationship: part_of GO:0061206 ! mesonephros morphogenesis
relationship: part_of GO:0061215 ! mesonephric nephron development
relationship: results_in_morphogenesis_of UBERON:0005322 ! mesonephric nephron
created_by: dph
creation_date: 2010-08-19T02:26:24Z

[Term]
id: GO:0061235
name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-08-19T02:57:11Z

[Term]
id: GO:0061241
name: mesonephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072163 ! mesonephric epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005330 ! mesonephric nephron epithelium
relationship: part_of GO:0061215 ! mesonephric nephron development
relationship: results_in_development_of UBERON:0005330 ! mesonephric nephron epithelium
created_by: dph
creation_date: 2010-08-19T03:11:59Z

[Term]
id: GO:0061243
name: mesonephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005331 ! mesonephric renal vesicle
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: results_in_morphogenesis_of UBERON:0005331 ! mesonephric renal vesicle
created_by: dph
creation_date: 2010-08-19T03:20:21Z

[Term]
id: GO:0061261
name: mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
is_a: GO:0061208 ! cell differentiation involved in mesonephros development
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0061206 ! mesonephros morphogenesis
relationship: part_of GO:0061206 ! mesonephros morphogenesis
created_by: dph
creation_date: 2010-08-30T02:35:15Z

[Term]
id: GO:0061262
name: mesonephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005331 ! mesonephric renal vesicle
relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005331 ! mesonephric renal vesicle
created_by: dph
creation_date: 2010-08-30T02:41:20Z

[Term]
id: GO:0061271
name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0061262 ! mesonephric renal vesicle formation
relationship: part_of GO:0061262 ! mesonephric renal vesicle formation
created_by: dph
creation_date: 2010-08-30T03:26:30Z

[Term]
id: GO:0061285
name: mesonephric capsule development
namespace: biological_process
def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006170 ! mesonephric capsule
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0006170 ! mesonephric capsule
created_by: dph
creation_date: 2010-09-02T01:50:06Z

[Term]
id: GO:0061286
name: mesonephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0006170 ! mesonephric capsule
relationship: part_of GO:0061285 ! mesonephric capsule development
relationship: results_in_morphogenesis_of UBERON:0006170 ! mesonephric capsule
created_by: dph
creation_date: 2010-09-02T01:53:31Z

[Term]
id: GO:0061287
name: mesonephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0006170 ! mesonephric capsule
relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0006170 ! mesonephric capsule
created_by: dph
creation_date: 2010-09-02T01:55:03Z

[Term]
id: GO:0061295
name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:48:56Z

[Term]
id: GO:0061296
name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061218 ! negative regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:54:49Z

[Term]
id: GO:0061297
name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT []
is_a: GO:0061213 ! positive regulation of mesonephros development
is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
relationship: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
created_by: dph
creation_date: 2010-09-06T09:58:59Z

[Term]
id: GO:0061298
name: retina vasculature development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature development" EXACT [GOC:dph]
is_a: GO:0001944 ! vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004864 ! vasculature of retina
relationship: part_of GO:0060041 ! retina development in camera-type eye
relationship: results_in_development_of UBERON:0004864 ! vasculature of retina
created_by: dph
creation_date: 2010-09-06T03:27:06Z

[Term]
id: GO:0061299
name: retina vasculature morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph]
synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004864 ! vasculature of retina
relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye
relationship: results_in_morphogenesis_of UBERON:0004864 ! vasculature of retina
created_by: dph
creation_date: 2010-09-06T03:28:25Z

[Term]
id: GO:0061303
name: cornea development in camera-type eye
namespace: biological_process
def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000964 ! cornea
relationship: part_of GO:0043010 ! camera-type eye development
relationship: results_in_development_of UBERON:0000964 ! cornea
created_by: dph
creation_date: 2010-09-14T02:09:08Z

[Term]
id: GO:0061304
name: retinal blood vessel morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003501 ! retina blood vessel
relationship: results_in_morphogenesis_of UBERON:0003501 ! retina blood vessel
created_by: dph
creation_date: 2010-09-16T09:02:59Z

[Term]
id: GO:0061307
name: cardiac neural crest cell differentiation involved in heart development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442]
is_a: GO:0014033 ! neural crest cell differentiation
is_a: GO:0035051 ! cardiocyte differentiation
intersection_of: GO:0014033 ! neural crest cell differentiation
intersection_of: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2010-09-23T08:50:56Z

[Term]
id: GO:0061308
name: cardiac neural crest cell development involved in heart development
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0014032 ! neural crest cell development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: part_of GO:0007507 ! heart development
relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development
created_by: dph
creation_date: 2010-09-23T09:01:49Z

[Term]
id: GO:0061309
name: cardiac neural crest cell development involved in outflow tract morphogenesis
namespace: biological_process
def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development
intersection_of: GO:0014032 ! neural crest cell development
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2010-09-23T09:08:37Z

[Term]
id: GO:0061323
name: cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2010-09-28T09:05:26Z

[Term]
id: GO:0061325
name: cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2010-09-28T09:29:30Z

[Term]
id: GO:0061326
name: renal tubule development
namespace: biological_process
def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0009773 ! renal tubule
relationship: part_of GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0009773 ! renal tubule
created_by: dph
creation_date: 2010-09-28T12:50:43Z

[Term]
id: GO:0061333
name: renal tubule morphogenesis
namespace: biological_process
def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0009773 ! renal tubule
relationship: part_of GO:0061326 ! renal tubule development
relationship: results_in_morphogenesis_of UBERON:0009773 ! renal tubule
created_by: dph
creation_date: 2010-09-28T01:43:04Z

[Term]
id: GO:0061337
name: cardiac conduction
namespace: biological_process
def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph]
is_a: GO:0008016 ! regulation of heart contraction
created_by: dph
creation_date: 2010-09-29T08:46:05Z

[Term]
id: GO:0061343
name: cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0007155 ! cell adhesion
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2010-09-29T11:34:06Z

[Term]
id: GO:0061344
name: regulation of cell adhesion involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis
relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T11:35:27Z

[Term]
id: GO:0061351
name: neural precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]
is_a: GO:0008283 ! cell population proliferation
created_by: dph
creation_date: 2010-10-01T11:06:04Z

[Term]
id: GO:0061383
name: trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000440 ! trabecula
relationship: results_in_morphogenesis_of UBERON:0000440 ! trabecula
created_by: dph
creation_date: 2010-12-02T08:51:45Z

[Term]
id: GO:0061384
name: heart trabecula morphogenesis
namespace: biological_process
def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
is_a: GO:0061383 ! trabecula morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002511 ! trabecula carnea
relationship: results_in_morphogenesis_of UBERON:0002511 ! trabecula carnea
created_by: dph
creation_date: 2010-12-02T08:54:20Z

[Term]
id: GO:0061385
name: fibroblast proliferation involved in heart morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph]
is_a: GO:0048144 ! fibroblast proliferation
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0048144 ! fibroblast proliferation
intersection_of: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2011-02-10T01:41:59Z

[Term]
id: GO:0061437
name: renal system vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0072001 ! renal system development
created_by: dph
creation_date: 2012-03-08T12:16:24Z

[Term]
id: GO:0061438
name: renal system vasculature morphogenesis
namespace: biological_process
def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0061437 ! renal system vasculature development
created_by: dph
creation_date: 2012-03-08T12:21:56Z

[Term]
id: GO:0061439
name: kidney vasculature morphogenesis
namespace: biological_process
def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0006544 ! kidney vasculature
relationship: part_of GO:0061438 ! renal system vasculature morphogenesis
relationship: part_of GO:0061440 ! kidney vasculature development
relationship: results_in_morphogenesis_of UBERON:0006544 ! kidney vasculature
created_by: dph
creation_date: 2012-03-08T12:30:11Z

[Term]
id: GO:0061440
name: kidney vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0061437 ! renal system vasculature development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006544 ! kidney vasculature
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0006544 ! kidney vasculature
created_by: dph
creation_date: 2012-03-08T12:39:09Z

[Term]
id: GO:0061441
name: renal artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001184 ! renal artery
relationship: part_of GO:0061439 ! kidney vasculature morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001184 ! renal artery
created_by: dph
creation_date: 2012-03-08T12:42:09Z

[Term]
id: GO:0061448
name: connective tissue development
namespace: biological_process
def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002384 ! connective tissue
relationship: results_in_development_of UBERON:0002384 ! connective tissue
created_by: dph
creation_date: 2012-03-22T12:53:41Z

[Term]
id: GO:0061450
name: trophoblast cell migration
namespace: biological_process
def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph]
is_a: GO:0001667 ! ameboidal-type cell migration
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000351 ! trophoblast cell
relationship: part_of GO:0007566 ! embryo implantation
relationship: results_in_movement_of CL:0000351 ! trophoblast cell
created_by: dph
creation_date: 2012-07-10T08:38:37Z

[Term]
id: GO:0061453
name: interstitial cell of Cajal differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph]
synonym: "ICC differentiation" RELATED [GOC:dph]
is_a: GO:0060563 ! neuroepithelial cell differentiation
is_a: GO:0060575 ! intestinal epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0002088 ! interstitial cell of Cajal
relationship: results_in_acquisition_of_features_of CL:0002088 ! interstitial cell of Cajal
created_by: dph
creation_date: 2012-07-20T08:20:50Z

[Term]
id: GO:0061458
name: reproductive system development
namespace: biological_process
def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph]
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000990 ! reproductive system
relationship: results_in_development_of UBERON:0000990 ! reproductive system
created_by: dph
creation_date: 2012-08-22T17:47:53Z

[Term]
id: GO:0061469
name: regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: dph
creation_date: 2012-11-01T13:16:23Z

[Term]
id: GO:0061484
name: hematopoietic stem cell homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411]
is_a: GO:0048872 ! homeostasis of number of cells
intersection_of: GO:0048872 ! homeostasis of number of cells
intersection_of: acts_on_population_of CL:0000037 ! hematopoietic stem cell
relationship: acts_on_population_of CL:0000037 ! hematopoietic stem cell
created_by: dph
creation_date: 2012-12-04T09:41:02Z

[Term]
id: GO:0061512
name: protein localization to cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005929 ! cilium
relationship: has_target_end_location GO:0005929 ! cilium
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
property_value: RO:0002161 NCBITaxon:3176
property_value: RO:0002161 NCBITaxon:3312
property_value: RO:0002161 NCBITaxon:3378
property_value: RO:0002161 NCBITaxon:3398
property_value: RO:0002161 NCBITaxon:4890
property_value: RO:0002161 NCBITaxon:5782
created_by: dph
creation_date: 2013-03-22T15:41:44Z

[Term]
id: GO:0061515
name: myeloid cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0030097 ! hemopoiesis
intersection_of: GO:0048468 ! cell development
intersection_of: results_in_development_of CL:0000763 ! myeloid cell
relationship: part_of GO:0030099 ! myeloid cell differentiation
relationship: results_in_development_of CL:0000763 ! myeloid cell
created_by: dph
creation_date: 2013-04-18T13:03:16Z

[Term]
id: GO:0061523
name: cilium disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent.
synonym: "cilium resorption" EXACT [GOC:dph]
is_a: GO:0044782 ! cilium organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005929 ! cilium
relationship: results_in_disassembly_of GO:0005929 ! cilium
created_by: dph
creation_date: 2013-04-18T14:59:59Z

[Term]
id: GO:0061525
name: hindgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph]
is_a: GO:0048565 ! digestive tract development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001046 ! hindgut
relationship: results_in_development_of UBERON:0001046 ! hindgut
created_by: dph
creation_date: 2013-06-14T11:22:21Z

[Term]
id: GO:0061526
name: acetylcholine secretion
namespace: biological_process
def: "The regulated release of acetylcholine by a cell." [GOC:dph]
is_a: GO:0015870 ! acetylcholine transport
is_a: GO:0023061 ! signal release
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
created_by: dph
creation_date: 2013-06-21T15:40:39Z

[Term]
id: GO:0061533
name: norepinephrine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph]
synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph]
is_a: GO:0048243 ! norepinephrine secretion
is_a: GO:0160043 ! catecholamine secretion, neurotransmission
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
created_by: dph
creation_date: 2013-06-21T16:05:08Z

[Term]
id: GO:0061548
name: ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "ganglia development" RELATED [GOC:dph]
synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl]
is_a: GO:0009888 ! tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000045 ! ganglion
relationship: part_of GO:0007399 ! nervous system development
relationship: results_in_development_of UBERON:0000045 ! ganglion
created_by: dph
creation_date: 2013-07-10T08:36:12Z

[Term]
id: GO:0061549
name: sympathetic ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl]
synonym: "sympathetic ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001806 ! sympathetic ganglion
relationship: part_of GO:0048485 ! sympathetic nervous system development
relationship: results_in_development_of UBERON:0001806 ! sympathetic ganglion
created_by: dph
creation_date: 2013-07-10T08:38:01Z

[Term]
id: GO:0061550
name: cranial ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "cranial ganglia development" RELATED [GOC:dph]
is_a: GO:0061548 ! ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001714 ! cranial ganglion
relationship: part_of GO:0021545 ! cranial nerve development
relationship: results_in_development_of UBERON:0001714 ! cranial ganglion
created_by: dph
creation_date: 2013-07-10T08:40:14Z

[Term]
id: GO:0061551
name: trigeminal ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph]
synonym: "trigeminal ganglia development" RELATED [GOC:dph]
is_a: GO:0061550 ! cranial ganglion development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001675 ! trigeminal ganglion
relationship: results_in_development_of UBERON:0001675 ! trigeminal ganglion
created_by: dph
creation_date: 2013-07-10T08:42:19Z

[Term]
id: GO:0061552
name: ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph]
synonym: "ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000045 ! ganglion
relationship: part_of GO:0061548 ! ganglion development
relationship: results_in_morphogenesis_of UBERON:0000045 ! ganglion
created_by: dph
creation_date: 2013-07-10T08:44:57Z

[Term]
id: GO:0061553
name: ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph]
synonym: "ganglia maturation" RELATED [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: results_in_maturation_of UBERON:0000045 ! ganglion
relationship: part_of GO:0061548 ! ganglion development
relationship: results_in_maturation_of UBERON:0000045 ! ganglion
created_by: dph
creation_date: 2013-07-10T08:45:59Z

[Term]
id: GO:0061554
name: ganglion formation
namespace: biological_process
def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "ganglia formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000045 ! ganglion
relationship: part_of GO:0061552 ! ganglion morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000045 ! ganglion
created_by: dph
creation_date: 2013-07-10T08:51:50Z

[Term]
id: GO:0061556
name: trigeminal ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph]
synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061559 ! cranial ganglion morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001675 ! trigeminal ganglion
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis
relationship: part_of GO:0061551 ! trigeminal ganglion development
relationship: results_in_morphogenesis_of UBERON:0001675 ! trigeminal ganglion
created_by: dph
creation_date: 2013-07-10T08:57:12Z

[Term]
id: GO:0061557
name: trigeminal ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph]
synonym: "trigeminal ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061558 ! cranial ganglion maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: results_in_maturation_of UBERON:0001675 ! trigeminal ganglion
relationship: part_of GO:0021635 ! trigeminal nerve maturation
relationship: part_of GO:0061551 ! trigeminal ganglion development
relationship: results_in_maturation_of UBERON:0001675 ! trigeminal ganglion
created_by: dph
creation_date: 2013-07-10T08:58:24Z

[Term]
id: GO:0061558
name: cranial ganglion maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph]
synonym: "cranial ganglia maturation" RELATED [GOC:dph]
is_a: GO:0061553 ! ganglion maturation
intersection_of: GO:0071695 ! anatomical structure maturation
intersection_of: results_in_maturation_of UBERON:0001714 ! cranial ganglion
relationship: part_of GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0061550 ! cranial ganglion development
relationship: results_in_maturation_of UBERON:0001714 ! cranial ganglion
created_by: dph
creation_date: 2013-07-10T08:59:52Z

[Term]
id: GO:0061559
name: cranial ganglion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph]
synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph]
is_a: GO:0061552 ! ganglion morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001714 ! cranial ganglion
relationship: part_of GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0061550 ! cranial ganglion development
relationship: results_in_morphogenesis_of UBERON:0001714 ! cranial ganglion
created_by: dph
creation_date: 2013-07-10T09:02:15Z

[Term]
id: GO:0061560
name: cranial ganglion formation
namespace: biological_process
def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "cranial ganglia formation" RELATED [GOC:dph]
is_a: GO:0061554 ! ganglion formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001714 ! cranial ganglion
relationship: part_of GO:0061559 ! cranial ganglion morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001714 ! cranial ganglion
created_by: dph
creation_date: 2013-07-10T09:07:27Z

[Term]
id: GO:0061561
name: trigeminal ganglion formation
namespace: biological_process
def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph]
synonym: "trigeminal ganglia formation" RELATED [GOC:dph]
is_a: GO:0061560 ! cranial ganglion formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001675 ! trigeminal ganglion
relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001675 ! trigeminal ganglion
created_by: dph
creation_date: 2013-07-10T09:08:13Z

[Term]
id: GO:0061572
name: actin filament bundle organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph]
synonym: "actin filament cable organization" RELATED [GOC:dph]
is_a: GO:0007015 ! actin filament organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0032432 ! actin filament bundle
relationship: results_in_organization_of GO:0032432 ! actin filament bundle
created_by: dph
creation_date: 2013-08-02T11:24:11Z

[Term]
id: GO:0061580
name: colon epithelial cell migration
namespace: biological_process
def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0061582 ! intestinal epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0011108 ! colon epithelial cell
relationship: results_in_movement_of CL:0011108 ! colon epithelial cell
created_by: dph
creation_date: 2013-12-23T07:26:54Z

[Term]
id: GO:0061581
name: corneal epithelial cell migration
namespace: biological_process
def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000575 ! corneal epithelial cell
relationship: results_in_movement_of CL:0000575 ! corneal epithelial cell
created_by: dph
creation_date: 2013-12-23T07:28:29Z

[Term]
id: GO:0061582
name: intestinal epithelial cell migration
namespace: biological_process
def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph]
is_a: GO:0010631 ! epithelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0002563 ! intestinal epithelial cell
relationship: results_in_movement_of CL:0002563 ! intestinal epithelial cell
created_by: dph
creation_date: 2013-12-23T07:30:55Z

[Term]
id: GO:0061626
name: pharyngeal arch artery morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914]
synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph]
is_a: GO:0048844 ! artery morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004363 ! pharyngeal arch artery
relationship: part_of GO:0060037 ! pharyngeal system development
relationship: results_in_morphogenesis_of UBERON:0004363 ! pharyngeal arch artery
created_by: dph
creation_date: 2014-05-09T15:34:06Z

[Term]
id: GO:0061682
name: seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022612 ! gland morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000998 ! seminal vesicle
relationship: part_of GO:0061107 ! seminal vesicle development
relationship: results_in_morphogenesis_of UBERON:0000998 ! seminal vesicle
created_by: dph
creation_date: 2015-03-04T13:33:49Z

[Term]
id: GO:0061683
name: branching involved in seminal vesicle morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376]
synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph]
synonym: "seminal vesicle branching" EXACT [GOC:dph]
synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: part_of GO:0061682 ! seminal vesicle morphogenesis
relationship: part_of GO:0061108 ! seminal vesicle epithelium development
relationship: part_of GO:0061682 ! seminal vesicle morphogenesis
created_by: dph
creation_date: 2015-03-04T13:39:47Z

[Term]
id: GO:0061687
name: detoxification of inorganic compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw]
is_a: GO:0098754 ! detoxification
intersection_of: GO:0098754 ! detoxification
intersection_of: has_primary_input CHEBI:24835 ! inorganic molecular entity
relationship: has_primary_input CHEBI:24835 ! inorganic molecular entity
created_by: dph
creation_date: 2015-03-09T09:16:23Z

[Term]
id: GO:0061695
name: transferase complex, transferring phosphorus-containing groups
namespace: cellular_component
def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]
is_a: GO:1990234 ! transferase complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of GO:0016772 ! transferase activity, transferring phosphorus-containing groups
relationship: capable_of GO:0016772 ! transferase activity, transferring phosphorus-containing groups
created_by: dph
creation_date: 2015-05-06T11:22:38Z

[Term]
id: GO:0061792
name: secretory granule maturation
namespace: biological_process
def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809]
is_a: GO:0033363 ! secretory granule organization
is_a: GO:0071695 ! anatomical structure maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of GO:0030141 ! secretory granule
relationship: results_in_maturation_of GO:0030141 ! secretory granule
created_by: dph
creation_date: 2016-09-09T13:24:34Z

[Term]
id: GO:0061853
name: regulation of neuroblast migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097402 ! neuroblast migration
relationship: regulates GO:0097402 ! neuroblast migration
created_by: dph
creation_date: 2017-03-08T18:17:07Z

[Term]
id: GO:0061854
name: positive regulation of neuroblast migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097402 ! neuroblast migration
relationship: positively_regulates GO:0097402 ! neuroblast migration
created_by: dph
creation_date: 2017-03-08T18:22:30Z

[Term]
id: GO:0061855
name: negative regulation of neuroblast migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0061853 ! regulation of neuroblast migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097402 ! neuroblast migration
relationship: negatively_regulates GO:0097402 ! neuroblast migration
created_by: dph
creation_date: 2017-03-08T18:26:21Z

[Term]
id: GO:0061900
name: glial cell activation
namespace: biological_process
def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000125 ! glial cell
relationship: has_primary_input CL:0000125 ! glial cell
relationship: part_of GO:0150076 ! neuroinflammatory response
created_by: dph
creation_date: 2017-06-13T13:06:23Z

[Term]
id: GO:0061938
name: protein localization to somatodendritic compartment
namespace: biological_process
def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993]
synonym: "somatodendritic protein localization" EXACT []
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0036477 ! somatodendritic compartment
relationship: has_target_end_location GO:0036477 ! somatodendritic compartment
created_by: dph
creation_date: 2017-09-08T13:22:26Z

[Term]
id: GO:0061951
name: establishment of protein localization to plasma membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw]
is_a: GO:0090150 ! establishment of protein localization to membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0005886 ! plasma membrane
intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_end_location GO:0005886 ! plasma membrane
relationship: has_target_start_location GO:0005622 ! intracellular anatomical structure
created_by: dph
creation_date: 2017-10-26T12:55:15Z

[Term]
id: GO:0061971
name: replacement bone morphogenesis
namespace: biological_process
def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [PMID:29852585]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0012075 ! replacement bone
relationship: results_in_morphogenesis_of UBERON:0012075 ! replacement bone
created_by: dph
creation_date: 2018-02-12T18:10:59Z

[Term]
id: GO:0061972
name: dermal bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632]
is_a: GO:0061973 ! membrane bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0008907 ! dermal bone
relationship: results_in_morphogenesis_of UBERON:0008907 ! dermal bone
created_by: dph
creation_date: 2018-02-12T18:16:21Z

[Term]
id: GO:0061973
name: membrane bone morphogenesis
namespace: biological_process
def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0060349 ! bone morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0007842 ! membrane bone
relationship: results_in_morphogenesis_of UBERON:0007842 ! membrane bone
created_by: dph
creation_date: 2018-02-12T18:21:09Z

[Term]
id: GO:0061983
name: meiosis II cell cycle process
namespace: biological_process
def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397]
synonym: "second meiotic division" EXACT [PMID:29385397]
is_a: GO:1903046 ! meiotic cell cycle process
created_by: dph
creation_date: 2018-02-14T22:37:44Z

[Term]
id: GO:0062012
name: regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]
synonym: "regulation of small molecule metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044281 ! small molecule metabolic process
relationship: regulates GO:0044281 ! small molecule metabolic process
created_by: dph
creation_date: 2018-03-19T14:11:54Z

[Term]
id: GO:0062013
name: positive regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "positive regulation of small molecule metabolism" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044281 ! small molecule metabolic process
relationship: positively_regulates GO:0044281 ! small molecule metabolic process
created_by: dph
creation_date: 2018-03-19T14:25:10Z

[Term]
id: GO:0062014
name: negative regulation of small molecule metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]
synonym: "negative regulation of small molecule metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044281 ! small molecule metabolic process
relationship: negatively_regulates GO:0044281 ! small molecule metabolic process
created_by: dph
creation_date: 2018-03-19T14:27:23Z

[Term]
id: GO:0062023
name: collagen-containing extracellular matrix
namespace: cellular_component
def: "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]
is_a: GO:0031012 ! extracellular matrix
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
created_by: dph
creation_date: 2018-04-13T12:47:21Z

[Term]
id: GO:0062033
name: positive regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000070 ! mitotic sister chromatid segregation
relationship: positively_regulates GO:0000070 ! mitotic sister chromatid segregation
created_by: dph
creation_date: 2018-04-23T14:32:23Z

[Term]
id: GO:0062094
name: stomach development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000945 ! stomach
relationship: part_of GO:0048565 ! digestive tract development
relationship: results_in_development_of UBERON:0000945 ! stomach
created_by: dph
creation_date: 2018-11-20T18:15:45Z

[Term]
id: GO:0062149
name: detection of stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031]
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
intersection_of: GO:0051606 ! detection of stimulus
intersection_of: part_of GO:0019233 ! sensory perception of pain
relationship: part_of GO:0019233 ! sensory perception of pain
created_by: dph
creation_date: 2019-09-13T13:48:47Z

[Term]
id: GO:0062223
name: regulation of somatic muscle development
namespace: biological_process
def: "Any process that regulates the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007525 ! somatic muscle development
relationship: regulates GO:0007525 ! somatic muscle development
created_by: dph
creation_date: 2020-03-13T18:58:37Z

[Term]
id: GO:0062224
name: positive regulation of somatic muscle development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0062223 ! regulation of somatic muscle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007525 ! somatic muscle development
relationship: positively_regulates GO:0007525 ! somatic muscle development
created_by: dph
creation_date: 2020-03-13T19:03:38Z

[Term]
id: GO:0062225
name: negative regulation of somatic muscle development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0062223 ! regulation of somatic muscle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007525 ! somatic muscle development
relationship: negatively_regulates GO:0007525 ! somatic muscle development
created_by: dph
creation_date: 2020-03-13T19:06:27Z

[Term]
id: GO:0062237
name: protein localization to postsynapse
namespace: biological_process
def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538]
is_a: GO:0035418 ! protein localization to synapse
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0098794 ! postsynapse
relationship: has_target_end_location GO:0098794 ! postsynapse
created_by: dph
creation_date: 2020-04-20T13:58:43Z

[Term]
id: GO:0065002
name: intracellular protein transmembrane transport
namespace: biological_process
def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "intracellular membrane translocation of a protein" EXACT []
synonym: "intracellular protein membrane transport" EXACT []
synonym: "intracellular protein transport across a membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0071806 ! protein transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure
intersection_of: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0065003
name: protein-containing complex assembly
namespace: biological_process
alt_id: GO:0006461
alt_id: GO:0034622
alt_id: GO:0043623
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_pombe
subset: goslim_prokaryote
synonym: "cellular macromolecule complex assembly" RELATED []
synonym: "cellular protein complex assembly" EXACT []
synonym: "cellular protein-containing complex assembly" RELATED []
synonym: "chaperone activity" RELATED []
synonym: "macromolecular complex assembly" RELATED []
synonym: "macromolecule complex assembly" RELATED []
synonym: "protein complex assembly" RELATED []
synonym: "protein complex formation" RELATED []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0032991 ! protein-containing complex
relationship: results_in_assembly_of GO:0032991 ! protein-containing complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22580" xsd:anyURI

[Term]
id: GO:0065004
name: protein-DNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]
synonym: "DNA-protein complex assembly" EXACT [GOC:mah]
is_a: GO:0065003 ! protein-containing complex assembly
is_a: GO:0071824 ! protein-DNA complex organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0032993 ! protein-DNA complex
relationship: results_in_assembly_of GO:0032993 ! protein-DNA complex

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: gocheck_do_not_annotate
subset: goslim_pir
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological process

[Term]
id: GO:0065008
name: regulation of biological quality
namespace: biological_process
def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
subset: goslim_pir
synonym: "regulation of biological attribute" EXACT []
synonym: "regulation of biological characteristic" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065009
name: regulation of molecular function
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]
subset: gocheck_do_not_annotate
subset: goslim_pir
subset: goslim_plant
synonym: "regulation of a molecular function" EXACT []
is_a: GO:0065007 ! biological regulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003674 ! molecular_function
relationship: regulates GO:0003674 ! molecular_function

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]
synonym: "extracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle
intersection_of: GO:0043227 ! membrane-bounded organelle
intersection_of: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0070013
name: intracellular organelle lumen
namespace: cellular_component
def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
intersection_of: GO:0031974 ! membrane-enclosed lumen
intersection_of: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0070050
name: neuron cellular homeostasis
namespace: biological_process
def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
synonym: "neuron maintenance" EXACT []
is_a: GO:0019725 ! cellular homeostasis
intersection_of: GO:0019725 ! cellular homeostasis
intersection_of: occurs_in CL:0000540 ! neuron
relationship: occurs_in CL:0000540 ! neuron
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24218" xsd:anyURI

[Term]
id: GO:0070062
name: extracellular exosome
namespace: cellular_component
def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
synonym: "exosome" EXACT [GOC:pr]
synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles]
is_a: GO:1903561 ! extracellular vesicle
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070091
name: glucagon secretion
namespace: biological_process
def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl]
is_a: GO:0030072 ! peptide hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:5391 ! glucagon
relationship: has_primary_input CHEBI:5391 ! glucagon

[Term]
id: GO:0070092
name: regulation of glucagon secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070091 ! glucagon secretion
relationship: regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070093
name: negative regulation of glucagon secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "down regulation of glucagon secretion" EXACT []
synonym: "down-regulation of glucagon secretion" EXACT []
synonym: "downregulation of glucagon secretion" EXACT []
synonym: "inhibition of glucagon secretion" NARROW []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070091 ! glucagon secretion
relationship: negatively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070094
name: positive regulation of glucagon secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "activation of glucagon secretion" NARROW []
synonym: "stimulation of glucagon secretion" NARROW []
synonym: "up regulation of glucagon secretion" EXACT []
synonym: "up-regulation of glucagon secretion" EXACT []
synonym: "upregulation of glucagon secretion" EXACT []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070091 ! glucagon secretion
relationship: positively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070161
name: anchoring junction
namespace: cellular_component
def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]
synonym: "anchoring cell junction" EXACT [GOC:mah]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0070192
name: chromosome organization involved in meiotic cell cycle
namespace: biological_process
def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]
synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah]
synonym: "meiotic chromosome organization" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0051276 ! chromosome organization
intersection_of: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0070199
name: establishment of protein localization to chromosome
namespace: biological_process
def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0005694 ! chromosome
relationship: has_target_end_location GO:0005694 ! chromosome

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045184 ! establishment of protein localization
relationship: regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:0070202
name: regulation of establishment of protein localization to chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah]
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070199 ! establishment of protein localization to chromosome
relationship: regulates GO:0070199 ! establishment of protein localization to chromosome

[Term]
id: GO:0070227
name: lymphocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "lymphocyte apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000542 ! lymphocyte
relationship: occurs_in CL:0000542 ! lymphocyte

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "regulation of lymphocyte apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070227 ! lymphocyte apoptotic process
relationship: regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070229
name: negative regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of lymphocyte apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070227 ! lymphocyte apoptotic process
relationship: negatively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070230
name: positive regulation of lymphocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of lymphocyte apoptosis" NARROW []
synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070227 ! lymphocyte apoptotic process
relationship: positively_regulates GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0070231
name: T cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "T cell apoptosis" NARROW []
synonym: "T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "T-cell apoptosis" EXACT [GOC:add]
synonym: "T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000084 ! T cell
relationship: occurs_in CL:0000084 ! T cell

[Term]
id: GO:0070232
name: regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "regulation of T cell apoptosis" NARROW []
synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070231 ! T cell apoptotic process
relationship: regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070233
name: negative regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "down regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of T cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of T cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T cell apoptosis" NARROW []
synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070231 ! T cell apoptotic process
relationship: negatively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070234
name: positive regulation of T cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
synonym: "activation of T cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T cell apoptosis" NARROW []
synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
synonym: "stimulation of T cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of T cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
is_a: GO:0070232 ! regulation of T cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070231 ! T cell apoptotic process
relationship: positively_regulates GO:0070231 ! T cell apoptotic process

[Term]
id: GO:0070253
name: somatostatin secretion
namespace: biological_process
def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input CHEBI:64628 ! somatostatin
relationship: has_primary_input CHEBI:64628 ! somatostatin

[Term]
id: GO:0070254
name: mucus secretion
namespace: biological_process
def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544]
synonym: "mucus production" EXACT [GOC:add]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0032941 ! secretion by tissue
intersection_of: GO:0046903 ! secretion
intersection_of: has_primary_input UBERON:0000912 ! mucus
relationship: has_primary_input UBERON:0000912 ! mucus

[Term]
id: GO:0070255
name: regulation of mucus secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "regulation of mucus production" EXACT [GOC:add]
is_a: GO:0050878 ! regulation of body fluid levels
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070254 ! mucus secretion
relationship: regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070256
name: negative regulation of mucus secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "negative regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070254 ! mucus secretion
relationship: negatively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070257
name: positive regulation of mucus secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add]
synonym: "positive regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070254 ! mucus secretion
relationship: positively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070285
name: pigment cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs]
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0000147 ! pigment cell
relationship: part_of GO:0050931 ! pigment cell differentiation
relationship: results_in_development_of CL:0000147 ! pigment cell

[Term]
id: GO:0070341
name: fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl]
synonym: "adipocyte proliferation" EXACT [GOC:sl]
synonym: "adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000136 ! adipocyte
relationship: acts_on_population_of CL:0000136 ! adipocyte

[Term]
id: GO:0070344
name: regulation of fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070341 ! fat cell proliferation
relationship: regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070345
name: negative regulation of fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070341 ! fat cell proliferation
relationship: negatively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070346
name: positive regulation of fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070341 ! fat cell proliferation
relationship: positively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070365
name: hepatocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884]
synonym: "liver cell differentiation" EXACT [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000182 ! hepatocyte
relationship: part_of GO:0001889 ! liver development
relationship: results_in_acquisition_of_features_of CL:0000182 ! hepatocyte

[Term]
id: GO:0070366
name: regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070365 ! hepatocyte differentiation
relationship: regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070367
name: negative regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070365 ! hepatocyte differentiation
relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070368
name: positive regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl]
synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070365 ! hepatocyte differentiation
relationship: positively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070382
name: exocytic vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT []
synonym: "exocytotic vesicle" EXACT [GOC:kad]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0099503 ! secretory vesicle
intersection_of: GO:0030133 ! transport vesicle
intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane

[Term]
id: GO:0070482
name: response to oxygen levels
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0070483
name: detection of hypoxia
namespace: biological_process
def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah]
synonym: "detection of reduced oxygen levels" EXACT [GOC:vk]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0003032 ! detection of oxygen

[Term]
id: GO:0070507
name: regulation of microtubule cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000226 ! microtubule cytoskeleton organization
relationship: regulates GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0070633
name: transepithelial transport
namespace: biological_process
def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: results_in_transport_across UBERON:0000483 ! epithelium
relationship: results_in_transport_across UBERON:0000483 ! epithelium
created_by: mah
creation_date: 2009-05-06T03:31:02Z

[Term]
id: GO:0070634
name: transepithelial ammonium transport
namespace: biological_process
def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
is_a: GO:0070633 ! transepithelial transport
is_a: GO:0071705 ! nitrogen compound transport
intersection_of: GO:0070633 ! transepithelial transport
intersection_of: has_primary_input CHEBI:28938 ! ammonium
relationship: has_primary_input CHEBI:28938 ! ammonium
created_by: mah
creation_date: 2009-05-06T03:34:43Z

[Term]
id: GO:0070661
name: leukocyte proliferation
namespace: biological_process
def: "The expansion of a leukocyte population by cell division." [GOC:add]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000738 ! leukocyte
relationship: acts_on_population_of CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
created_by: mah
creation_date: 2009-05-28T05:25:28Z

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070661 ! leukocyte proliferation
relationship: regulates GO:0070661 ! leukocyte proliferation
created_by: mah
creation_date: 2009-05-28T05:30:39Z

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070661 ! leukocyte proliferation
relationship: negatively_regulates GO:0070661 ! leukocyte proliferation
created_by: mah
creation_date: 2009-05-28T05:34:50Z

[Term]
id: GO:0070665
name: positive regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "activation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070661 ! leukocyte proliferation
relationship: positively_regulates GO:0070661 ! leukocyte proliferation
created_by: mah
creation_date: 2009-05-28T05:36:46Z

[Term]
id: GO:0070727
name: cellular macromolecule localization
namespace: biological_process
def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "cellular macromolecule localisation" EXACT [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization
created_by: mah
creation_date: 2009-06-16T04:08:29Z

[Term]
id: GO:0070831
name: basement membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer.
is_a: GO:0071711 ! basement membrane organization
is_a: GO:0085029 ! extracellular matrix assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0005604 ! basement membrane
relationship: results_in_assembly_of GO:0005604 ! basement membrane
created_by: mah
creation_date: 2009-07-23T05:01:51Z

[Term]
id: GO:0070857
name: regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of bile acid formation" EXACT [GOC:mah]
synonym: "regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006699 ! bile acid biosynthetic process
relationship: regulates GO:0006699 ! bile acid biosynthetic process
created_by: mah
creation_date: 2009-08-14T03:09:02Z

[Term]
id: GO:0070858
name: negative regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of bile acid formation" EXACT [GOC:mah]
synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904252 ! negative regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006699 ! bile acid biosynthetic process
relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process
created_by: mah
creation_date: 2009-08-14T03:16:40Z

[Term]
id: GO:0070859
name: positive regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of bile acid formation" EXACT [GOC:mah]
synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah]
synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
is_a: GO:1904253 ! positive regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006699 ! bile acid biosynthetic process
relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process
created_by: mah
creation_date: 2009-08-14T03:22:58Z

[Term]
id: GO:0070873
name: regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005977 ! glycogen metabolic process
relationship: regulates GO:0005977 ! glycogen metabolic process
created_by: mah
creation_date: 2009-08-20T02:44:53Z

[Term]
id: GO:0070874
name: negative regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005977 ! glycogen metabolic process
relationship: negatively_regulates GO:0005977 ! glycogen metabolic process
created_by: mah
creation_date: 2009-08-20T02:50:41Z

[Term]
id: GO:0070875
name: positive regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005977 ! glycogen metabolic process
relationship: positively_regulates GO:0005977 ! glycogen metabolic process
created_by: mah
creation_date: 2009-08-20T02:53:55Z

[Term]
id: GO:0070925
name: organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0043226 ! organelle
relationship: results_in_assembly_of GO:0043226 ! organelle
created_by: mah
creation_date: 2009-09-15T03:00:51Z

[Term]
id: GO:0070977
name: bone maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah]
is_a: GO:0048799 ! animal organ maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0001474 ! bone element
relationship: part_of GO:0060348 ! bone development
relationship: results_in_maturation_of UBERON:0001474 ! bone element
created_by: mah
creation_date: 2009-10-05T04:35:31Z

[Term]
id: GO:0071168
name: protein localization to chromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0000785 ! chromatin
relationship: has_target_end_location GO:0000785 ! chromatin
created_by: mah
creation_date: 2009-11-20T11:51:20Z

[Term]
id: GO:0071169
name: establishment of protein localization to chromatin
namespace: biological_process
def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah]
synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0000785 ! chromatin
relationship: has_target_end_location GO:0000785 ! chromatin
created_by: mah
creation_date: 2009-11-20T11:52:43Z

[Term]
id: GO:0071425
name: hematopoietic stem cell proliferation
namespace: biological_process
def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl]
synonym: "hemopoietic stem cell proliferation" EXACT []
is_a: GO:0072089 ! stem cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000037 ! hematopoietic stem cell
relationship: acts_on_population_of CL:0000037 ! hematopoietic stem cell
relationship: part_of GO:0030097 ! hemopoiesis
created_by: mah
creation_date: 2009-12-16T10:22:52Z

[Term]
id: GO:0071626
name: mastication
namespace: biological_process
def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg]
synonym: "chewing" EXACT [GOC:mah]
is_a: GO:0022600 ! digestive system process
created_by: mah
creation_date: 2010-02-10T11:19:48Z

[Term]
id: GO:0071674
name: mononuclear cell migration
namespace: biological_process
def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000842 ! mononuclear cell
relationship: results_in_movement_of CL:0000842 ! mononuclear cell
created_by: mah
creation_date: 2010-02-16T02:11:00Z

[Term]
id: GO:0071675
name: regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071674 ! mononuclear cell migration
relationship: regulates GO:0071674 ! mononuclear cell migration
created_by: mah
creation_date: 2010-02-16T02:11:53Z

[Term]
id: GO:0071676
name: negative regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071674 ! mononuclear cell migration
relationship: negatively_regulates GO:0071674 ! mononuclear cell migration
created_by: mah
creation_date: 2010-02-16T02:13:55Z

[Term]
id: GO:0071677
name: positive regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "activation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071674 ! mononuclear cell migration
relationship: positively_regulates GO:0071674 ! mononuclear cell migration
created_by: mah
creation_date: 2010-02-16T02:15:29Z

[Term]
id: GO:0071692
name: protein localization to extracellular region
namespace: biological_process
def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah]
synonym: "protein localisation in extracellular region" EXACT [GOC:mah]
synonym: "protein localization in extracellular region" EXACT []
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005576 ! extracellular region
relationship: has_target_end_location GO:0005576 ! extracellular region
created_by: mah
creation_date: 2010-02-25T04:00:13Z

[Term]
id: GO:0071695
name: anatomical structure maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]
is_a: GO:0021700 ! developmental maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0000061 ! anatomical structure
relationship: part_of GO:0048856 ! anatomical structure development
relationship: results_in_maturation_of UBERON:0000061 ! anatomical structure
created_by: mah
creation_date: 2010-03-02T11:43:38Z

[Term]
id: GO:0071696
name: ectodermal placode development
namespace: biological_process
def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005085 ! ectodermal placode
relationship: results_in_development_of UBERON:0005085 ! ectodermal placode
created_by: mah
creation_date: 2010-03-02T11:48:01Z

[Term]
id: GO:0071697
name: ectodermal placode morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005085 ! ectodermal placode
relationship: part_of GO:0071696 ! ectodermal placode development
relationship: results_in_morphogenesis_of UBERON:0005085 ! ectodermal placode
created_by: mah
creation_date: 2010-03-02T11:49:51Z

[Term]
id: GO:0071702
name: organic substance transport
namespace: biological_process
def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity
relationship: has_primary_input CHEBI:50860 ! organic molecular entity
created_by: mah
creation_date: 2010-03-08T02:15:14Z

[Term]
id: GO:0071704
name: organic substance metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]
subset: gocheck_do_not_annotate
synonym: "organic molecular entity metabolic process" EXACT []
synonym: "organic molecular entity metabolism" EXACT []
synonym: "organic substance metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:50860 ! organic molecular entity
relationship: has_primary_input_or_output CHEBI:50860 ! organic molecular entity
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI
created_by: mah
creation_date: 2010-03-08T03:32:18Z

[Term]
id: GO:0071705
name: nitrogen compound transport
namespace: biological_process
def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:51143 ! nitrogen molecular entity
relationship: has_primary_input CHEBI:51143 ! nitrogen molecular entity
created_by: mah
creation_date: 2010-03-08T03:56:28Z

[Term]
id: GO:0071709
name: membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0016020 ! membrane
relationship: part_of GO:0044091 ! membrane biogenesis
relationship: results_in_assembly_of GO:0016020 ! membrane
created_by: mah
creation_date: 2010-03-10T11:19:17Z

[Term]
id: GO:0071711
name: basement membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]
comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer.
synonym: "basement membrane organisation" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005604 ! basement membrane
relationship: results_in_organization_of GO:0005604 ! basement membrane
created_by: mah
creation_date: 2010-03-10T11:57:10Z

[Term]
id: GO:0071763
name: nuclear membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]
synonym: "nuclear membrane organisation" EXACT [GOC:mah]
synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0061024 ! membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0031965 ! nuclear membrane
relationship: part_of GO:0006998 ! nuclear envelope organization
relationship: results_in_organization_of GO:0031965 ! nuclear membrane
created_by: mah
creation_date: 2010-03-29T03:59:35Z

[Term]
id: GO:0071764
name: nuclear outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah]
synonym: "nuclear outer membrane organisation" EXACT [GOC:mah]
synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071763 ! nuclear membrane organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0005640 ! nuclear outer membrane
relationship: results_in_organization_of GO:0005640 ! nuclear outer membrane
created_by: mah
creation_date: 2010-03-29T04:03:37Z

[Term]
id: GO:0071806
name: protein transmembrane transport
namespace: biological_process
def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "protein membrane transport" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0055085 ! transmembrane transport
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: mah
creation_date: 2010-09-03T02:54:26Z

[Term]
id: GO:0071824
name: protein-DNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah]
synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah]
synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah]
synonym: "protein-DNA complex subunit organization" EXACT []
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0032993 ! protein-DNA complex
relationship: results_in_organization_of GO:0032993 ! protein-DNA complex
created_by: mah
creation_date: 2010-09-08T10:03:26Z

[Term]
id: GO:0071826
name: protein-RNA complex organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah]
synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex subunit organization" EXACT []
synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah]
is_a: GO:0043933 ! protein-containing complex organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:1990904 ! ribonucleoprotein complex
relationship: results_in_organization_of GO:1990904 ! ribonucleoprotein complex
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/25143" xsd:anyURI
created_by: mah
creation_date: 2010-09-08T10:10:35Z

[Term]
id: GO:0071840
name: cellular component organization or biogenesis
namespace: biological_process
alt_id: GO:0071841
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]
subset: goslim_flybase_ribbon
subset: goslim_metagenomics
synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah]
synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular component organization or biogenesis at cellular level" EXACT []
is_a: GO:0009987 ! cellular process
created_by: mah
creation_date: 2010-09-10T01:39:16Z

[Term]
id: GO:0071867
name: response to monoamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah]
synonym: "response to monoamine stimulus" EXACT [GOC:dos]
is_a: GO:0010243 ! response to organonitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:63534 ! monoamine
relationship: has_primary_input CHEBI:63534 ! monoamine
created_by: mah
creation_date: 2010-09-13T02:36:37Z

[Term]
id: GO:0071869
name: response to catecholamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah]
synonym: "response to catecholamine stimulus" EXACT [GOC:dos]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0071867 ! response to monoamine
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:33567 ! catecholamine
relationship: has_primary_input CHEBI:33567 ! catecholamine
created_by: mah
creation_date: 2010-09-13T02:51:13Z

[Term]
id: GO:0071873
name: response to norepinephrine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah]
comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors.
synonym: "response to noradrenaline stimulus" EXACT [GOC:mah]
synonym: "response to norepinephrine stimulus" EXACT [GOC:dos]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
relationship: has_primary_input CHEBI:72587 ! (R)-noradrenaline(1+)
created_by: mah
creation_date: 2010-09-13T03:31:53Z

[Term]
id: GO:0071887
name: leukocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "leukocyte apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000738 ! leukocyte
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: occurs_in CL:0000738 ! leukocyte
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
created_by: mah
creation_date: 2010-09-14T12:44:09Z

[Term]
id: GO:0071897
name: DNA biosynthetic process
namespace: biological_process
def: "The biosynthetic process resulting in the formation of DNA." [GOC:mah]
synonym: "DNA anabolism" EXACT [GOC:mah]
synonym: "DNA biosynthesis" EXACT [GOC:mah]
synonym: "DNA formation" EXACT [GOC:mah]
synonym: "DNA synthesis" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:16991 ! deoxyribonucleic acid
relationship: has_primary_output CHEBI:16991 ! deoxyribonucleic acid
created_by: mah
creation_date: 2010-09-15T02:14:33Z

[Term]
id: GO:0071944
name: cell periphery
namespace: cellular_component
def: "The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]
subset: goslim_flybase_ribbon
is_a: GO:0110165 ! cellular anatomical entity
created_by: mah
creation_date: 2010-10-04T01:51:47Z

[Term]
id: GO:0071953
name: elastic fiber
namespace: cellular_component
def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620]
synonym: "elastic fibre" EXACT [GOC:mah]
synonym: "elastin fiber" EXACT [GOC:BHF]
is_a: GO:0099512 ! supramolecular fiber
relationship: part_of GO:0031012 ! extracellular matrix
created_by: mah
creation_date: 2010-10-11T11:44:57Z

[Term]
id: GO:0071971
name: extracellular exosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458]
synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0070062 ! extracellular exosome
relationship: part_of GO:0097734 ! extracellular exosome biogenesis
relationship: results_in_assembly_of GO:0070062 ! extracellular exosome
created_by: mah
creation_date: 2010-10-18T03:44:18Z

[Term]
id: GO:0072001
name: renal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]
subset: gocheck_do_not_annotate
synonym: "urinary system development" BROAD [GOC:yaf]
synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463]
is_a: GO:0048731 ! system development
intersection_of: GO:0048731 ! system development
intersection_of: results_in_development_of UBERON:0001008 ! renal system
relationship: results_in_development_of UBERON:0001008 ! renal system
created_by: mah
creation_date: 2010-01-25T10:31:00Z

[Term]
id: GO:0072003
name: kidney rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005095 ! kidney rudiment
relationship: part_of GO:0060993 ! kidney morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005095 ! kidney rudiment
created_by: mah
creation_date: 2010-01-25T11:18:58Z

[Term]
id: GO:0072006
name: nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
synonym: "nephrogenesis" RELATED [GOC:rph]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001285 ! nephron
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0001285 ! nephron
created_by: mah
creation_date: 2010-01-25T01:37:16Z

[Term]
id: GO:0072009
name: nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004211 ! nephron epithelium
relationship: part_of GO:0072006 ! nephron development
relationship: results_in_development_of UBERON:0004211 ! nephron epithelium
created_by: mah
creation_date: 2010-01-25T02:01:39Z

[Term]
id: GO:0072028
name: nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001285 ! nephron
relationship: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0072006 ! nephron development
relationship: results_in_morphogenesis_of UBERON:0001285 ! nephron
created_by: mah
creation_date: 2010-01-25T02:45:52Z

[Term]
id: GO:0072033
name: renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004209 ! renal vesicle
relationship: part_of GO:0072077 ! renal vesicle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0004209 ! renal vesicle
created_by: mah
creation_date: 2010-01-25T02:57:03Z

[Term]
id: GO:0072036
name: mesenchymal to epithelial transition involved in renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
is_a: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0072033 ! renal vesicle formation
relationship: part_of GO:0072033 ! renal vesicle formation
created_by: mah
creation_date: 2010-01-25T03:04:24Z

[Term]
id: GO:0072038
name: mesenchymal stem cell maintenance involved in nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035019 ! somatic stem cell population maintenance
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: mah
creation_date: 2010-01-25T03:08:05Z

[Term]
id: GO:0072039
name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: mah
creation_date: 2010-01-25T03:08:34Z

[Term]
id: GO:0072040
name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: mah
creation_date: 2010-01-25T03:09:30Z

[Term]
id: GO:0072041
name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
created_by: mah
creation_date: 2010-01-25T03:10:32Z

[Term]
id: GO:0072044
name: collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001232 ! collecting duct of renal tubule
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0001232 ! collecting duct of renal tubule
created_by: mah
creation_date: 2010-01-25T03:18:06Z

[Term]
id: GO:0072048
name: renal system pattern specification
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10]
subset: gocheck_do_not_annotate
synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0072001 ! renal system development
created_by: mah
creation_date: 2010-01-25T03:31:51Z

[Term]
id: GO:0072055
name: renal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001225 ! cortex of kidney
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0001225 ! cortex of kidney
created_by: mah
creation_date: 2010-01-25T04:01:12Z

[Term]
id: GO:0072059
name: cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004203 ! cortical collecting duct
relationship: results_in_development_of UBERON:0004203 ! cortical collecting duct
created_by: mah
creation_date: 2010-01-25T04:07:07Z

[Term]
id: GO:0072071
name: kidney interstitial fibroblast differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000692 ! kidney interstitial fibroblast
relationship: results_in_acquisition_of_features_of CL:1000692 ! kidney interstitial fibroblast
created_by: mah
creation_date: 2010-01-25T04:34:31Z

[Term]
id: GO:0072073
name: kidney epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004819 ! kidney epithelium
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0004819 ! kidney epithelium
created_by: mah
creation_date: 2010-01-25T04:37:42Z

[Term]
id: GO:0072074
name: kidney mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003918 ! kidney mesenchyme
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0003918 ! kidney mesenchyme
created_by: mah
creation_date: 2010-01-25T04:39:04Z

[Term]
id: GO:0072075
name: metanephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003220 ! metanephric mesenchyme
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0003220 ! metanephric mesenchyme
created_by: mah
creation_date: 2010-01-25T04:40:11Z

[Term]
id: GO:0072076
name: nephrogenic mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004208 ! nephrogenic mesenchyme
relationship: part_of GO:0072006 ! nephron development
relationship: results_in_development_of UBERON:0004208 ! nephrogenic mesenchyme
created_by: mah
creation_date: 2010-01-25T04:40:44Z

[Term]
id: GO:0072077
name: renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004209 ! renal vesicle
relationship: part_of GO:0072087 ! renal vesicle development
relationship: part_of GO:0072088 ! nephron epithelium morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004209 ! renal vesicle
created_by: mah
creation_date: 2010-02-01T02:21:06Z

[Term]
id: GO:0072078
name: nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061333 ! renal tubule morphogenesis
is_a: GO:0072088 ! nephron epithelium morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001231 ! nephron tubule
relationship: part_of GO:0072080 ! nephron tubule development
relationship: results_in_morphogenesis_of UBERON:0001231 ! nephron tubule
created_by: mah
creation_date: 2010-02-01T02:25:14Z

[Term]
id: GO:0072079
name: nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0001838 ! embryonic epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0001231 ! nephron tubule
relationship: part_of GO:0072078 ! nephron tubule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0001231 ! nephron tubule
created_by: mah
creation_date: 2010-02-01T02:29:26Z

[Term]
id: GO:0072080
name: nephron tubule development
namespace: biological_process
def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0061326 ! renal tubule development
is_a: GO:0072009 ! nephron epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001231 ! nephron tubule
relationship: results_in_development_of UBERON:0001231 ! nephron tubule
created_by: mah
creation_date: 2010-02-01T02:32:12Z

[Term]
id: GO:0072087
name: renal vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004209 ! renal vesicle
relationship: part_of GO:0072009 ! nephron epithelium development
relationship: results_in_development_of UBERON:0004209 ! renal vesicle
created_by: mah
creation_date: 2010-02-08T01:18:31Z

[Term]
id: GO:0072088
name: nephron epithelium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004211 ! nephron epithelium
relationship: part_of GO:0072009 ! nephron epithelium development
relationship: part_of GO:0072028 ! nephron morphogenesis
relationship: results_in_morphogenesis_of UBERON:0004211 ! nephron epithelium
created_by: mah
creation_date: 2010-02-08T01:19:06Z

[Term]
id: GO:0072089
name: stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000034 ! stem cell
relationship: acts_on_population_of CL:0000034 ! stem cell
relationship: has_part GO:0017145 ! stem cell division
created_by: mah
creation_date: 2010-02-08T02:03:36Z

[Term]
id: GO:0072091
name: regulation of stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072089 ! stem cell proliferation
relationship: regulates GO:0072089 ! stem cell proliferation
created_by: mah
creation_date: 2010-02-08T02:09:03Z

[Term]
id: GO:0072093
name: metanephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072033 ! renal vesicle formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005147 ! metanephric renal vesicle
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005147 ! metanephric renal vesicle
created_by: mah
creation_date: 2010-02-10T01:17:11Z

[Term]
id: GO:0072098
name: anterior/posterior pattern specification involved in kidney development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0001822 ! kidney development
created_by: mah
creation_date: 2010-02-10T02:06:24Z

[Term]
id: GO:0072099
name: anterior/posterior pattern specification involved in ureteric bud development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061227 ! pattern specification involved in mesonephros development
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
intersection_of: GO:0009952 ! anterior/posterior pattern specification
intersection_of: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0001657 ! ureteric bud development
created_by: mah
creation_date: 2010-02-10T02:12:09Z

[Term]
id: GO:0072105
name: ureteric peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0014849 ! ureter smooth muscle contraction
is_a: GO:0030432 ! peristalsis
intersection_of: GO:0030432 ! peristalsis
intersection_of: occurs_in UBERON:0000056 ! ureter
relationship: occurs_in UBERON:0000056 ! ureter
created_by: mah
creation_date: 2010-02-10T03:07:54Z

[Term]
id: GO:0072106
name: regulation of ureteric bud formation
namespace: biological_process
def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0061217 ! regulation of mesonephros development
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060676 ! ureteric bud formation
relationship: regulates GO:0060676 ! ureteric bud formation
created_by: mah
creation_date: 2010-02-12T02:34:40Z

[Term]
id: GO:0072107
name: positive regulation of ureteric bud formation
namespace: biological_process
def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0072106 ! regulation of ureteric bud formation
is_a: GO:0110110 ! positive regulation of animal organ morphogenesis
is_a: GO:1905278 ! positive regulation of epithelial tube formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060676 ! ureteric bud formation
relationship: positively_regulates GO:0060676 ! ureteric bud formation
created_by: mah
creation_date: 2010-02-12T02:37:28Z

[Term]
id: GO:0072108
name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: mah
creation_date: 2010-02-12T02:45:57Z

[Term]
id: GO:0072111
name: cell proliferation involved in kidney development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0001822 ! kidney development
created_by: mah
creation_date: 2010-02-22T10:48:45Z

[Term]
id: GO:0072114
name: pronephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0060993 ! kidney morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002120 ! pronephros
relationship: part_of GO:0048793 ! pronephros development
relationship: results_in_morphogenesis_of UBERON:0002120 ! pronephros
created_by: mah
creation_date: 2010-02-22T11:12:15Z

[Term]
id: GO:0072116
name: pronephros formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048645 ! animal organ formation
is_a: GO:0072003 ! kidney rudiment formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002120 ! pronephros
relationship: part_of GO:0072114 ! pronephros morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002120 ! pronephros
created_by: mah
creation_date: 2010-02-22T11:16:26Z

[Term]
id: GO:0072120
name: pronephros maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048799 ! animal organ maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of UBERON:0002120 ! pronephros
relationship: part_of GO:0048793 ! pronephros development
relationship: results_in_maturation_of UBERON:0002120 ! pronephros
created_by: mah
creation_date: 2010-02-22T11:25:48Z

[Term]
id: GO:0072127
name: renal capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0061448 ! connective tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002015 ! kidney capsule
relationship: part_of GO:0001822 ! kidney development
relationship: results_in_development_of UBERON:0002015 ! kidney capsule
created_by: mah
creation_date: 2010-02-22T02:02:55Z

[Term]
id: GO:0072128
name: renal capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002015 ! kidney capsule
relationship: part_of GO:0072127 ! renal capsule development
relationship: results_in_morphogenesis_of UBERON:0002015 ! kidney capsule
created_by: mah
creation_date: 2010-02-22T02:06:19Z

[Term]
id: GO:0072129
name: renal capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0002015 ! kidney capsule
relationship: part_of GO:0072128 ! renal capsule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0002015 ! kidney capsule
created_by: mah
creation_date: 2010-02-22T02:08:14Z

[Term]
id: GO:0072131
name: kidney mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072132 ! mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003918 ! kidney mesenchyme
relationship: part_of GO:0072074 ! kidney mesenchyme development
relationship: results_in_morphogenesis_of UBERON:0003918 ! kidney mesenchyme
created_by: mah
creation_date: 2010-02-22T02:16:43Z

[Term]
id: GO:0072132
name: mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003104 ! mesenchyme
relationship: part_of GO:0009887 ! animal organ morphogenesis
relationship: part_of GO:0060485 ! mesenchyme development
relationship: results_in_morphogenesis_of UBERON:0003104 ! mesenchyme
created_by: mah
creation_date: 2010-02-22T02:17:15Z

[Term]
id: GO:0072133
name: metanephric mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003220 ! metanephric mesenchyme
relationship: part_of GO:0072075 ! metanephric mesenchyme development
relationship: results_in_morphogenesis_of UBERON:0003220 ! metanephric mesenchyme
created_by: mah
creation_date: 2010-02-22T02:20:14Z

[Term]
id: GO:0072134
name: nephrogenic mesenchyme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0004208 ! nephrogenic mesenchyme
relationship: part_of GO:0072076 ! nephrogenic mesenchyme development
relationship: results_in_morphogenesis_of UBERON:0004208 ! nephrogenic mesenchyme
created_by: mah
creation_date: 2010-02-22T02:21:16Z

[Term]
id: GO:0072138
name: mesenchymal cell proliferation involved in ureteric bud development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0061209 ! cell proliferation involved in mesonephros development
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0001657 ! ureteric bud development
relationship: part_of GO:0001657 ! ureteric bud development
created_by: mah
creation_date: 2010-02-22T02:40:38Z

[Term]
id: GO:0072141
name: renal interstitial fibroblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:1000692 ! kidney interstitial fibroblast
relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation
relationship: results_in_development_of CL:1000692 ! kidney interstitial fibroblast
created_by: mah
creation_date: 2010-02-24T01:39:05Z

[Term]
id: GO:0072155
name: epithelial cell migration involved in nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0035787 ! cell migration involved in kidney development
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072078 ! nephron tubule morphogenesis
created_by: mah
creation_date: 2010-02-24T02:21:25Z

[Term]
id: GO:0072160
name: nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000494 ! nephron tubule epithelial cell
relationship: part_of GO:0072080 ! nephron tubule development
relationship: results_in_acquisition_of_features_of CL:1000494 ! nephron tubule epithelial cell
created_by: mah
creation_date: 2010-02-24T02:40:11Z

[Term]
id: GO:0072161
name: mesenchymal cell differentiation involved in kidney development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0001822 ! kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development
created_by: mah
creation_date: 2010-02-26T01:31:49Z

[Term]
id: GO:0072163
name: mesonephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005103 ! mesonephric epithelium
relationship: part_of GO:0001823 ! mesonephros development
relationship: results_in_development_of UBERON:0005103 ! mesonephric epithelium
created_by: mah
creation_date: 2010-02-26T01:40:43Z

[Term]
id: GO:0072164
name: mesonephric tubule development
namespace: biological_process
def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072163 ! mesonephric epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000083 ! mesonephric tubule
relationship: results_in_development_of UBERON:0000083 ! mesonephric tubule
created_by: mah
creation_date: 2010-02-26T01:45:58Z

[Term]
id: GO:0072170
name: metanephric tubule development
namespace: biological_process
def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072207 ! metanephric epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005106 ! metanephric tubule
relationship: results_in_development_of UBERON:0005106 ! metanephric tubule
created_by: mah
creation_date: 2010-02-26T01:58:18Z

[Term]
id: GO:0072171
name: mesonephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000083 ! mesonephric tubule
relationship: part_of GO:0072164 ! mesonephric tubule development
relationship: results_in_morphogenesis_of UBERON:0000083 ! mesonephric tubule
created_by: mah
creation_date: 2010-02-26T02:02:13Z

[Term]
id: GO:0072172
name: mesonephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0000083 ! mesonephric tubule
relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0000083 ! mesonephric tubule
created_by: mah
creation_date: 2010-02-26T02:02:37Z

[Term]
id: GO:0072173
name: metanephric tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005106 ! metanephric tubule
relationship: part_of GO:0072170 ! metanephric tubule development
relationship: results_in_morphogenesis_of UBERON:0005106 ! metanephric tubule
created_by: mah
creation_date: 2010-02-26T02:06:42Z

[Term]
id: GO:0072174
name: metanephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005106 ! metanephric tubule
relationship: part_of GO:0072173 ! metanephric tubule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005106 ! metanephric tubule
created_by: mah
creation_date: 2010-02-26T02:07:41Z

[Term]
id: GO:0072175
name: epithelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
is_a: GO:0035148 ! tube formation
intersection_of: GO:0035148 ! tube formation
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003914 ! epithelial tube
relationship: part_of GO:0060562 ! epithelial tube morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003914 ! epithelial tube
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22302" xsd:anyURI
created_by: mah
creation_date: 2010-02-26T02:15:40Z

[Term]
id: GO:0072176
name: nephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0072073 ! kidney epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0009201 ! nephric duct
relationship: results_in_development_of UBERON:0009201 ! nephric duct
created_by: mah
creation_date: 2010-02-26T02:27:31Z

[Term]
id: GO:0072177
name: mesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct development" EXACT [GOC:dph]
is_a: GO:0072164 ! mesonephric tubule development
is_a: GO:0072176 ! nephric duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003074 ! mesonephric duct
relationship: results_in_development_of UBERON:0003074 ! mesonephric duct
created_by: mah
creation_date: 2010-02-26T02:32:22Z

[Term]
id: GO:0072178
name: nephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0009201 ! nephric duct
relationship: part_of GO:0072176 ! nephric duct development
relationship: results_in_morphogenesis_of UBERON:0009201 ! nephric duct
created_by: mah
creation_date: 2010-02-26T02:35:29Z

[Term]
id: GO:0072179
name: nephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0009201 ! nephric duct
relationship: part_of GO:0072178 ! nephric duct morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0009201 ! nephric duct
created_by: mah
creation_date: 2010-02-26T02:35:55Z

[Term]
id: GO:0072180
name: mesonephric duct morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph]
is_a: GO:0072171 ! mesonephric tubule morphogenesis
is_a: GO:0072178 ! nephric duct morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0003074 ! mesonephric duct
relationship: part_of GO:0072177 ! mesonephric duct development
relationship: results_in_morphogenesis_of UBERON:0003074 ! mesonephric duct
created_by: mah
creation_date: 2010-02-26T02:37:13Z

[Term]
id: GO:0072181
name: mesonephric duct formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10]
synonym: "Wolffian duct formation" EXACT [GOC:dph]
is_a: GO:0072172 ! mesonephric tubule formation
is_a: GO:0072179 ! nephric duct formation
is_a: GO:0072180 ! mesonephric duct morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003074 ! mesonephric duct
relationship: results_in_formation_of_anatomical_entity UBERON:0003074 ! mesonephric duct
created_by: mah
creation_date: 2010-02-26T02:38:03Z

[Term]
id: GO:0072182
name: regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: mah
creation_date: 2010-02-26T02:45:09Z

[Term]
id: GO:0072183
name: negative regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: mah
creation_date: 2010-02-26T02:47:25Z

[Term]
id: GO:0072189
name: ureter development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! animal organ development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000056 ! ureter
relationship: part_of GO:0072001 ! renal system development
relationship: results_in_development_of UBERON:0000056 ! ureter
created_by: mah
creation_date: 2010-03-01T01:44:14Z

[Term]
id: GO:0072191
name: ureter smooth muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0009919 ! ureter smooth muscle
relationship: part_of GO:0072189 ! ureter development
relationship: results_in_development_of UBERON:0009919 ! ureter smooth muscle
created_by: mah
creation_date: 2010-03-01T01:48:53Z

[Term]
id: GO:0072193
name: ureter smooth muscle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10]
is_a: GO:0051145 ! smooth muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000979 ! ureter smooth muscle cell
relationship: part_of GO:0072191 ! ureter smooth muscle development
relationship: results_in_acquisition_of_features_of CL:1000979 ! ureter smooth muscle cell
created_by: mah
creation_date: 2010-03-01T01:55:01Z

[Term]
id: GO:0072194
name: kidney smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048745 ! smooth muscle tissue development
relationship: part_of GO:0001822 ! kidney development
created_by: mah
creation_date: 2010-03-01T02:05:30Z

[Term]
id: GO:0072197
name: ureter morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0009887 ! animal organ morphogenesis
is_a: GO:0035239 ! tube morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000056 ! ureter
relationship: part_of GO:0072189 ! ureter development
relationship: results_in_morphogenesis_of UBERON:0000056 ! ureter
created_by: mah
creation_date: 2010-03-01T02:24:55Z

[Term]
id: GO:0072198
name: mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10]
synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
intersection_of: GO:0010463 ! mesenchymal cell proliferation
intersection_of: part_of GO:0072189 ! ureter development
relationship: part_of GO:0072189 ! ureter development
created_by: mah
creation_date: 2010-03-01T03:24:41Z

[Term]
id: GO:0072199
name: regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: mah
creation_date: 2010-03-01T03:38:13Z

[Term]
id: GO:0072200
name: negative regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: mah
creation_date: 2010-03-01T03:42:31Z

[Term]
id: GO:0072201
name: negative regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010463 ! mesenchymal cell proliferation
relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation
created_by: mah
creation_date: 2010-03-01T03:43:29Z

[Term]
id: GO:0072202
name: cell differentiation involved in metanephros development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-18T10:40:14Z

[Term]
id: GO:0072203
name: cell proliferation involved in metanephros development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-18T10:42:27Z

[Term]
id: GO:0072204
name: cell-cell signaling involved in metanephros development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]
synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah]
is_a: GO:0060995 ! cell-cell signaling involved in kidney development
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-18T10:54:36Z

[Term]
id: GO:0072205
name: metanephric collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004737 ! metanephric collecting duct
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0004737 ! metanephric collecting duct
created_by: mah
creation_date: 2010-03-18T11:15:37Z

[Term]
id: GO:0072207
name: metanephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005108 ! metanephric epithelium
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0005108 ! metanephric epithelium
created_by: mah
creation_date: 2010-03-18T11:50:37Z

[Term]
id: GO:0072208
name: metanephric smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072194 ! kidney smooth muscle tissue development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005109 ! metanephric smooth muscle tissue
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0005109 ! metanephric smooth muscle tissue
created_by: mah
creation_date: 2010-03-18T11:51:59Z

[Term]
id: GO:0072210
name: metanephric nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005110 ! metanephric nephron
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0005110 ! metanephric nephron
created_by: mah
creation_date: 2010-03-18T12:52:57Z

[Term]
id: GO:0072213
name: metanephric capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072127 ! renal capsule development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005137 ! metanephric capsule
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0005137 ! metanephric capsule
created_by: mah
creation_date: 2010-03-18T01:25:19Z

[Term]
id: GO:0072214
name: metanephric cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
is_a: GO:0072055 ! renal cortex development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005113 ! metanephric cortex mesenchyme
relationship: part_of GO:0001656 ! metanephros development
relationship: results_in_development_of UBERON:0005113 ! metanephric cortex mesenchyme
created_by: mah
creation_date: 2010-03-18T01:29:49Z

[Term]
id: GO:0072215
name: regulation of metanephros development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001656 ! metanephros development
relationship: regulates GO:0001656 ! metanephros development

[Term]
id: GO:0072216
name: positive regulation of metanephros development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090184 ! positive regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001656 ! metanephros development
relationship: positively_regulates GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-18T01:40:12Z

[Term]
id: GO:0072217
name: negative regulation of metanephros development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:0090185 ! negative regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001656 ! metanephros development
relationship: negatively_regulates GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-18T01:45:48Z

[Term]
id: GO:0072219
name: metanephric cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0072059 ! cortical collecting duct development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005115 ! metanephric cortical collecting duct
relationship: results_in_development_of UBERON:0005115 ! metanephric cortical collecting duct
created_by: mah
creation_date: 2010-03-18T03:34:52Z

[Term]
id: GO:0072234
name: metanephric nephron tubule development
namespace: biological_process
def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072170 ! metanephric tubule development
is_a: GO:0072243 ! metanephric nephron epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005146 ! metanephric nephron tubule
relationship: results_in_development_of UBERON:0005146 ! metanephric nephron tubule
created_by: mah
creation_date: 2010-03-18T03:41:23Z

[Term]
id: GO:0072243
name: metanephric nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development
is_a: GO:0072207 ! metanephric epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005134 ! metanephric nephron epithelium
relationship: results_in_development_of UBERON:0005134 ! metanephric nephron epithelium
created_by: mah
creation_date: 2010-03-19T03:29:49Z

[Term]
id: GO:0072257
name: metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072160 ! nephron tubule epithelial cell differentiation
is_a: GO:0072202 ! cell differentiation involved in metanephros development
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:1000123 ! metanephric nephron tubule epithelial cell
relationship: part_of GO:0072234 ! metanephric nephron tubule development
relationship: results_in_acquisition_of_features_of CL:1000123 ! metanephric nephron tubule epithelial cell
created_by: mah
creation_date: 2010-03-19T04:11:02Z

[Term]
id: GO:0072265
name: metanephric capsule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072128 ! renal capsule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005137 ! metanephric capsule
relationship: part_of GO:0072213 ! metanephric capsule development
relationship: results_in_morphogenesis_of UBERON:0005137 ! metanephric capsule
created_by: mah
creation_date: 2010-03-30T02:54:49Z

[Term]
id: GO:0072266
name: metanephric capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10]
is_a: GO:0072129 ! renal capsule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005137 ! metanephric capsule
relationship: part_of GO:0072265 ! metanephric capsule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005137 ! metanephric capsule
created_by: mah
creation_date: 2010-03-30T02:56:35Z

[Term]
id: GO:0072268
name: pattern specification involved in metanephros development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development
intersection_of: GO:0007389 ! pattern specification process
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: mah
creation_date: 2010-03-30T03:06:30Z

[Term]
id: GO:0072273
name: metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072028 ! nephron morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005110 ! metanephric nephron
relationship: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072210 ! metanephric nephron development
relationship: results_in_morphogenesis_of UBERON:0005110 ! metanephric nephron
created_by: mah
creation_date: 2010-03-30T03:33:19Z

[Term]
id: GO:0072282
name: metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
is_a: GO:0072173 ! metanephric tubule morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005146 ! metanephric nephron tubule
relationship: part_of GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: results_in_morphogenesis_of UBERON:0005146 ! metanephric nephron tubule
created_by: mah
creation_date: 2010-04-01T03:25:11Z

[Term]
id: GO:0072283
name: metanephric renal vesicle morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072077 ! renal vesicle morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0005147 ! metanephric renal vesicle
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: results_in_morphogenesis_of UBERON:0005147 ! metanephric renal vesicle
created_by: mah
creation_date: 2010-04-01T03:28:00Z

[Term]
id: GO:0072285
name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0072093 ! metanephric renal vesicle formation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation
created_by: mah
creation_date: 2010-04-01T03:43:31Z

[Term]
id: GO:0072289
name: metanephric nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
is_a: GO:0072174 ! metanephric tubule formation
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0005146 ! metanephric nephron tubule
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0005146 ! metanephric nephron tubule
created_by: mah
creation_date: 2010-04-09T03:47:44Z

[Term]
id: GO:0072290
name: epithelial cell migration involved in metanephric nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0035788 ! cell migration involved in metanephros development
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
intersection_of: GO:0010631 ! epithelial cell migration
intersection_of: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis
created_by: mah
creation_date: 2010-04-09T03:52:29Z

[Term]
id: GO:0072304
name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072305
name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072306
name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW []
synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT []
is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
relationship: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072307
name: regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072308
name: negative regulation of metanephric nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation
is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072309
name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis
namespace: biological_process
def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: mah
creation_date: 2010-04-09T05:03:41Z

[Term]
id: GO:0072329
name: monocarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:35757 ! monocarboxylic acid anion
relationship: has_primary_input CHEBI:35757 ! monocarboxylic acid anion
created_by: mah
creation_date: 2010-11-02T04:41:55Z

[Term]
id: GO:0072330
name: monocarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]
synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah]
synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah]
synonym: "monocarboxylic acid formation" EXACT [GOC:mah]
synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah]
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:35757 ! monocarboxylic acid anion
relationship: has_primary_output CHEBI:35757 ! monocarboxylic acid anion
created_by: mah
creation_date: 2010-11-02T04:51:32Z

[Term]
id: GO:0072348
name: sulfur compound transport
namespace: biological_process
def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]
synonym: "sulfur-containing compound transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity
relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity
created_by: mah
creation_date: 2010-11-11T11:43:56Z

[Term]
id: GO:0072359
name: circulatory system development
namespace: biological_process
alt_id: GO:0072358
def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]
subset: goslim_drosophila
synonym: "cardiovascular system development" NARROW []
is_a: GO:0048731 ! system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001009 ! circulatory system
relationship: results_in_development_of UBERON:0001009 ! circulatory system
created_by: mah
creation_date: 2010-11-16T11:27:39Z

[Term]
id: GO:0072360
name: vascular cord development
namespace: biological_process
def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006965 ! vascular cord
relationship: part_of GO:0072359 ! circulatory system development
relationship: results_in_development_of UBERON:0006965 ! vascular cord
created_by: mah
creation_date: 2010-11-16T11:46:55Z

[Term]
id: GO:0072384
name: organelle transport along microtubule
namespace: biological_process
def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]
synonym: "microtubule-based organelle localization" EXACT [GOC:rl]
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0051656 ! establishment of organelle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input GO:0043226 ! organelle
intersection_of: results_in_transport_along GO:0005874 ! microtubule
created_by: mah
creation_date: 2010-12-01T04:59:11Z

[Term]
id: GO:0072488
name: ammonium transmembrane transport
namespace: biological_process
alt_id: GO:0015696
def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "ammonia transport" BROAD []
synonym: "ammonium membrane transport" EXACT []
synonym: "ammonium transport" BROAD []
is_a: GO:0071705 ! nitrogen compound transport
is_a: GO:0098662 ! inorganic cation transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:28938 ! ammonium
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:28938 ! ammonium
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22228" xsd:anyURI
created_by: mah
creation_date: 2010-12-10T10:29:57Z

[Term]
id: GO:0072520
name: seminiferous tubule development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343]
is_a: GO:0035295 ! tube development
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001343 ! seminiferous tubule of testis
relationship: part_of GO:0008584 ! male gonad development
relationship: results_in_development_of UBERON:0001343 ! seminiferous tubule of testis
created_by: mah
creation_date: 2011-01-04T12:50:36Z

[Term]
id: GO:0072537
name: fibroblast activation
namespace: biological_process
def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah]
is_a: GO:0001775 ! cell activation
intersection_of: GO:0001775 ! cell activation
intersection_of: has_primary_input CL:0000057 ! fibroblast
relationship: has_primary_input CL:0000057 ! fibroblast
created_by: mah
creation_date: 2011-01-14T04:35:08Z

[Term]
id: GO:0072560
name: type B pancreatic cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF]
comment: These processes continue to 60 DPA in Gossypium spp.
synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah]
synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah]
is_a: GO:0002071 ! glandular epithelial cell maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of CL:0000169 ! type B pancreatic cell
relationship: part_of GO:0003323 ! type B pancreatic cell development
relationship: results_in_maturation_of CL:0000169 ! type B pancreatic cell
created_by: mah
creation_date: 2011-01-27T01:57:14Z

[Term]
id: GO:0072575
name: epithelial cell proliferation involved in liver morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0072576 ! liver morphogenesis
relationship: part_of GO:0072576 ! liver morphogenesis
created_by: mah
creation_date: 2011-02-02T03:37:50Z

[Term]
id: GO:0072576
name: liver morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah]
is_a: GO:0022612 ! gland morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002107 ! liver
relationship: part_of GO:0001889 ! liver development
relationship: results_in_morphogenesis_of UBERON:0002107 ! liver
created_by: mah
creation_date: 2011-02-02T03:41:30Z

[Term]
id: GO:0072577
name: endothelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "apoptosis of endothelial cells" EXACT [GOC:mah]
synonym: "endothelial cell apoptosis" NARROW []
synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah]
synonym: "killing of endothelial cells" EXACT [GOC:mah]
synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah]
synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah]
is_a: GO:1904019 ! epithelial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000115 ! endothelial cell
relationship: occurs_in CL:0000115 ! endothelial cell
created_by: mah
creation_date: 2011-02-02T03:56:24Z

[Term]
id: GO:0072592
name: oxygen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah]
synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263]
synonym: "oxygen metabolism" EXACT [GOC:mah]
is_a: GO:0044237 ! cellular metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:15379 ! dioxygen
relationship: has_primary_input_or_output CHEBI:15379 ! dioxygen
created_by: mah
creation_date: 2011-02-11T10:46:51Z

[Term]
id: GO:0072594
name: establishment of protein localization to organelle
namespace: biological_process
def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]
synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0043226 ! organelle
relationship: has_target_end_location GO:0043226 ! organelle
created_by: mah
creation_date: 2011-02-14T01:56:51Z

[Term]
id: GO:0072657
name: protein localization to membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]
subset: goslim_prokaryote
synonym: "protein localisation in membrane" EXACT [GOC:mah]
synonym: "protein localization in membrane" EXACT []
is_a: GO:0008104 ! protein localization
is_a: GO:0051668 ! localization within membrane
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0016020 ! membrane
created_by: mah
creation_date: 2011-02-14T02:35:18Z

[Term]
id: GO:0072659
name: protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0072661
alt_id: GO:0090002
def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]
subset: goslim_generic
subset: goslim_pombe
synonym: "protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "protein localization in plasma membrane" RELATED []
synonym: "protein targeting to plasma membrane" RELATED []
synonym: "protein-plasma membrane targeting" RELATED [GOC:mah]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005886 ! plasma membrane
intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_end_location GO:0005886 ! plasma membrane
relationship: has_target_start_location GO:0005622 ! intracellular anatomical structure
created_by: tb
creation_date: 2009-07-10T10:29:23Z

[Term]
id: GO:0072665
name: protein localization to vacuole
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd]
synonym: "protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization to organelle
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005773 ! vacuole
relationship: has_target_end_location GO:0005773 ! vacuole
created_by: mah
creation_date: 2011-02-14T02:55:35Z

[Term]
id: GO:0072666
name: establishment of protein localization to vacuole
namespace: biological_process
def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah]
synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah]
is_a: GO:0072594 ! establishment of protein localization to organelle
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0005773 ! vacuole
relationship: has_target_end_location GO:0005773 ! vacuole
created_by: mah
creation_date: 2011-02-14T02:56:29Z

[Term]
id: GO:0072676
name: lymphocyte migration
namespace: biological_process
def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah]
is_a: GO:0071674 ! mononuclear cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000542 ! lymphocyte
relationship: results_in_movement_of CL:0000542 ! lymphocyte
created_by: mah
creation_date: 2011-02-22T03:38:12Z

[Term]
id: GO:0072678
name: T cell migration
namespace: biological_process
def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah]
synonym: "T lymphocyte migration" EXACT [CL:0000084]
synonym: "T-cell migration" EXACT [CL:0000084]
synonym: "T-lymphocyte migration" EXACT [CL:0000084]
is_a: GO:0072676 ! lymphocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000084 ! T cell
relationship: results_in_movement_of CL:0000084 ! T cell
created_by: mah
creation_date: 2011-02-22T03:40:40Z

[Term]
id: GO:0072697
name: protein localization to cell cortex
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah]
synonym: "protein localisation to cell cortex" EXACT [GOC:mah]
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005938 ! cell cortex
relationship: has_target_end_location GO:0005938 ! cell cortex
created_by: mah
creation_date: 2012-04-11T01:16:33Z

[Term]
id: GO:0072698
name: protein localization to microtubule cytoskeleton
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah]
synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044380 ! protein localization to cytoskeleton
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0015630 ! microtubule cytoskeleton
relationship: has_target_end_location GO:0015630 ! microtubule cytoskeleton
created_by: mah
creation_date: 2012-04-11T01:19:35Z

[Term]
id: GO:0080090
name: regulation of primary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]
is_a: GO:0019222 ! regulation of metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044238 ! primary metabolic process
relationship: regulates GO:0044238 ! primary metabolic process
created_by: dhl
creation_date: 2009-04-22T04:30:52Z

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.
subset: gocheck_do_not_manually_annotate
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006950 ! response to stress
relationship: regulates GO:0006950 ! response to stress
created_by: dhl
creation_date: 2009-05-06T04:51:28Z

[Term]
id: GO:0080154
name: regulation of fertilization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994]
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009566 ! fertilization
relationship: regulates GO:0009566 ! fertilization
created_by: dhl
creation_date: 2010-09-01T03:44:27Z

[Term]
id: GO:0085029
name: extracellular matrix assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030198 ! extracellular matrix organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0031012 ! extracellular matrix
relationship: results_in_assembly_of GO:0031012 ! extracellular matrix
created_by: jl
creation_date: 2010-07-14T12:52:49Z

[Term]
id: GO:0086001
name: cardiac muscle cell action potential
namespace: biological_process
def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0001508 ! action potential
intersection_of: GO:0001508 ! action potential
intersection_of: occurs_in CL:0000746 ! cardiac muscle cell
relationship: occurs_in CL:0000746 ! cardiac muscle cell
created_by: tb
creation_date: 2011-11-10T07:45:11Z

[Term]
id: GO:0086015
name: SA node cell action potential
namespace: biological_process
def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell action potential" EXACT []
synonym: "SAN cardiac muscle cell action potential" EXACT []
synonym: "sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: occurs_in CL:1000409 ! myocyte of sinoatrial node
relationship: occurs_in CL:1000409 ! myocyte of sinoatrial node
relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signaling
created_by: tb
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0086016
name: AV node cell action potential
namespace: biological_process
def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: occurs_in CL:1000410 ! myocyte of atrioventricular node
relationship: occurs_in CL:1000410 ! myocyte of atrioventricular node
relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling
created_by: tb
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086017
name: Purkinje myocyte action potential
namespace: biological_process
def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086001 ! cardiac muscle cell action potential
intersection_of: GO:0001508 ! action potential
intersection_of: occurs_in CL:0002068 ! Purkinje myocyte
relationship: occurs_in CL:0002068 ! Purkinje myocyte
relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling
created_by: tb
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0086018
name: SA node cell to atrial cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW []
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication
created_by: tb
creation_date: 2011-11-10T09:15:01Z

[Term]
id: GO:0086019
name: cell-cell signaling involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0086065 ! cell communication involved in cardiac conduction
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-16T03:43:52Z

[Term]
id: GO:0086027
name: AV node cell to bundle of His cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node to bundle of His cell signaling" EXACT []
synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086067 ! AV node cell to bundle of His cell communication
created_by: tb
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086029
name: Purkinje myocyte to ventricular cardiac muscle cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah]
is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction
is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:2000046 ! ventricular cardiac muscle cell
intersection_of: has_start_location CL:0002068 ! Purkinje myocyte
relationship: has_end_location CL:2000046 ! ventricular cardiac muscle cell
relationship: has_start_location CL:0002068 ! Purkinje myocyte
created_by: tb
creation_date: 2011-11-11T02:02:14Z

[Term]
id: GO:0086065
name: cell communication involved in cardiac conduction
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0007154 ! cell communication
intersection_of: GO:0007154 ! cell communication
intersection_of: part_of GO:0061337 ! cardiac conduction
relationship: part_of GO:0061337 ! cardiac conduction
created_by: dph
creation_date: 2011-11-22T08:57:02Z

[Term]
id: GO:0086067
name: AV node cell to bundle of His cell communication
namespace: biological_process
def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "atrioventricular node cell to bundle of His cell communication" EXACT []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:11:44Z

[Term]
id: GO:0086068
name: Purkinje myocyte to ventricular cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:14:49Z

[Term]
id: GO:0086070
name: SA node cell to atrial cardiac muscle cell communication
namespace: biological_process
def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT []
synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT []
synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW []
is_a: GO:0086065 ! cell communication involved in cardiac conduction
created_by: dph
creation_date: 2011-11-22T09:32:45Z

[Term]
id: GO:0090009
name: primitive streak formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004341 ! primitive streak
relationship: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0009948 ! anterior/posterior axis specification
relationship: results_in_formation_of_anatomical_entity UBERON:0004341 ! primitive streak
created_by: tb
creation_date: 2009-07-29T10:31:31Z

[Term]
id: GO:0090063
name: positive regulation of microtubule nucleation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031116 ! positive regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007020 ! microtubule nucleation
relationship: positively_regulates GO:0007020 ! microtubule nucleation
created_by: tb
creation_date: 2009-08-12T11:33:09Z

[Term]
id: GO:0090068
name: positive regulation of cell cycle process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0045787 ! positive regulation of cell cycle
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022402 ! cell cycle process
relationship: positively_regulates GO:0022402 ! cell cycle process
created_by: tb
creation_date: 2009-09-09T11:39:52Z

[Term]
id: GO:0090069
name: regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042254 ! ribosome biogenesis
relationship: regulates GO:0042254 ! ribosome biogenesis
created_by: tb
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090070
name: positive regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042254 ! ribosome biogenesis
relationship: positively_regulates GO:0042254 ! ribosome biogenesis
created_by: tb
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090071
name: negative regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042254 ! ribosome biogenesis
relationship: negatively_regulates GO:0042254 ! ribosome biogenesis
created_by: tb
creation_date: 2009-09-11T10:32:17Z

[Term]
id: GO:0090087
name: regulation of peptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015833 ! peptide transport
relationship: regulates GO:0015833 ! peptide transport
created_by: tb
creation_date: 2009-10-23T11:21:38Z

[Term]
id: GO:0090091
name: positive regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022617 ! extracellular matrix disassembly
relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly
created_by: tb
creation_date: 2009-11-04T10:03:25Z

[Term]
id: GO:0090130
name: tissue migration
namespace: biological_process
def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process
created_by: tb
creation_date: 2009-12-07T03:13:55Z

[Term]
id: GO:0090132
name: epithelium migration
namespace: biological_process
def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
created_by: tb
creation_date: 2009-12-07T03:19:34Z

[Term]
id: GO:0090138
name: regulation of actin cytoskeleton organization by cell-cell adhesion
namespace: biological_process
def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0098609 ! cell-cell adhesion
intersection_of: GO:0098609 ! cell-cell adhesion
intersection_of: regulates GO:0030036 ! actin cytoskeleton organization
created_by: tb
creation_date: 2009-12-08T02:05:00Z

[Term]
id: GO:0090150
name: establishment of protein localization to membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah]
synonym: "establishment of protein localization in membrane" EXACT []
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0051668 ! localization within membrane
intersection_of: GO:0045184 ! establishment of protein localization
intersection_of: has_target_end_location GO:0016020 ! membrane
created_by: tb
creation_date: 2009-12-08T03:18:51Z

[Term]
id: GO:0090162
name: establishment of epithelial cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: occurs_in CL:0000066 ! epithelial cell
relationship: occurs_in CL:0000066 ! epithelial cell
created_by: tb
creation_date: 2009-12-08T08:58:27Z

[Term]
id: GO:0090166
name: Golgi disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus disassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005794 ! Golgi apparatus
relationship: part_of GO:0048313 ! Golgi inheritance
relationship: results_in_disassembly_of GO:0005794 ! Golgi apparatus
created_by: tb
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090168
name: Golgi reassembly
namespace: biological_process
def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi apparatus reassembly" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0048313 ! Golgi inheritance
created_by: tb
creation_date: 2009-12-08T09:15:11Z

[Term]
id: GO:0090170
name: regulation of Golgi inheritance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:1903358 ! regulation of Golgi organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048313 ! Golgi inheritance
relationship: regulates GO:0048313 ! Golgi inheritance
created_by: tb
creation_date: 2009-12-11T10:21:59Z

[Term]
id: GO:0090171
name: chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_maturation_of CL:0000138 ! chondrocyte
relationship: part_of GO:0002063 ! chondrocyte development
relationship: results_in_maturation_of CL:0000138 ! chondrocyte
created_by: tb
creation_date: 2009-12-11T10:36:02Z

[Term]
id: GO:0090174
name: organelle membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048284 ! organelle fusion
is_a: GO:0061025 ! membrane fusion
intersection_of: GO:0061025 ! membrane fusion
intersection_of: results_in_fusion_of GO:0031090 ! organelle membrane
relationship: results_in_fusion_of GO:0031090 ! organelle membrane
created_by: tb
creation_date: 2009-12-11T11:44:58Z

[Term]
id: GO:0090183
name: regulation of kidney development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001822 ! kidney development
relationship: regulates GO:0001822 ! kidney development
created_by: tb
creation_date: 2009-12-18T10:50:56Z

[Term]
id: GO:0090184
name: positive regulation of kidney development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001822 ! kidney development
relationship: positively_regulates GO:0001822 ! kidney development
created_by: tb
creation_date: 2009-12-18T10:52:01Z

[Term]
id: GO:0090185
name: negative regulation of kidney development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf]
synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001822 ! kidney development
relationship: negatively_regulates GO:0001822 ! kidney development
created_by: tb
creation_date: 2009-12-18T10:58:45Z

[Term]
id: GO:0090189
name: regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:0090183 ! regulation of kidney development
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tb
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090190
name: positive regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tb
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090191
name: negative regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis
created_by: tb
creation_date: 2009-12-18T11:11:17Z

[Term]
id: GO:0090257
name: regulation of muscle system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003012 ! muscle system process
relationship: regulates GO:0003012 ! muscle system process
created_by: tb
creation_date: 2010-02-03T11:48:13Z

[Term]
id: GO:0090273
name: regulation of somatostatin secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070253 ! somatostatin secretion
relationship: regulates GO:0070253 ! somatostatin secretion
created_by: tb
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090274
name: positive regulation of somatostatin secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070253 ! somatostatin secretion
relationship: positively_regulates GO:0070253 ! somatostatin secretion
created_by: tb
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090275
name: negative regulation of somatostatin secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070253 ! somatostatin secretion
relationship: negatively_regulates GO:0070253 ! somatostatin secretion
created_by: tb
creation_date: 2010-02-05T02:54:14Z

[Term]
id: GO:0090276
name: regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030072 ! peptide hormone secretion
relationship: regulates GO:0030072 ! peptide hormone secretion
created_by: tb
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090277
name: positive regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030072 ! peptide hormone secretion
relationship: positively_regulates GO:0030072 ! peptide hormone secretion
created_by: tb
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090278
name: negative regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030072 ! peptide hormone secretion
relationship: negatively_regulates GO:0030072 ! peptide hormone secretion
created_by: tb
creation_date: 2010-02-05T02:56:39Z

[Term]
id: GO:0090299
name: regulation of neural crest formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014029 ! neural crest formation
relationship: regulates GO:0014029 ! neural crest formation
created_by: tb
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090300
name: positive regulation of neural crest formation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb]
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014029 ! neural crest formation
relationship: positively_regulates GO:0014029 ! neural crest formation
created_by: tb
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090301
name: negative regulation of neural crest formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb]
is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition
is_a: GO:0090299 ! regulation of neural crest formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014029 ! neural crest formation
relationship: negatively_regulates GO:0014029 ! neural crest formation
created_by: tb
creation_date: 2010-03-12T04:08:26Z

[Term]
id: GO:0090304
name: nucleic acid metabolic process
namespace: biological_process
def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb]
is_a: GO:0006139 ! nucleobase-containing compound metabolic process
is_a: GO:0043170 ! macromolecule metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33696 ! nucleic acid
relationship: has_primary_input_or_output CHEBI:33696 ! nucleic acid
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26133" xsd:anyURI
created_by: tb
creation_date: 2010-04-07T10:18:47Z

[Term]
id: GO:0090316
name: positive regulation of intracellular protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051222 ! positive regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006886 ! intracellular protein transport
relationship: positively_regulates GO:0006886 ! intracellular protein transport
created_by: tb
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090317
name: negative regulation of intracellular protein transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0051224 ! negative regulation of protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006886 ! intracellular protein transport
relationship: negatively_regulates GO:0006886 ! intracellular protein transport
created_by: tb
creation_date: 2010-04-16T03:45:07Z

[Term]
id: GO:0090325
name: regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050795 ! regulation of behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tb
creation_date: 2010-05-14T10:24:29Z

[Term]
id: GO:0090326
name: positive regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tb
creation_date: 2010-05-14T10:26:58Z

[Term]
id: GO:0090327
name: negative regulation of locomotion involved in locomotory behavior
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior
relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior
created_by: tb
creation_date: 2010-05-14T10:26:58Z

[Term]
id: GO:0090425
name: acinar cell differentiation
namespace: biological_process
def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb]
is_a: GO:0002067 ! glandular epithelial cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000622 ! acinar cell
relationship: results_in_acquisition_of_features_of CL:0000622 ! acinar cell
created_by: tb
creation_date: 2012-05-04T09:24:48Z

[Term]
id: GO:0090435
name: protein localization to nuclear envelope
namespace: biological_process
def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb]
synonym: "protein localization in nuclear envelope" EXACT []
is_a: GO:0034504 ! protein localization to nucleus
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005635 ! nuclear envelope
relationship: has_target_end_location GO:0005635 ! nuclear envelope
created_by: tb
creation_date: 2012-07-30T01:50:41Z

[Term]
id: GO:0090493
name: catecholamine uptake
namespace: biological_process
def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb]
is_a: GO:0051937 ! catecholamine transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:33567 ! catecholamine
intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure
intersection_of: has_target_start_location GO:0005576 ! extracellular region
relationship: has_target_end_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_start_location GO:0005576 ! extracellular region
created_by: tb
creation_date: 2012-10-17T11:06:17Z

[Term]
id: GO:0090497
name: mesenchymal cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal-type cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0008019 ! mesenchymal cell
relationship: results_in_movement_of CL:0008019 ! mesenchymal cell
created_by: tb
creation_date: 2012-10-17T12:08:17Z

[Term]
id: GO:0090596
name: sensory organ morphogenesis
namespace: biological_process
def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]
is_a: GO:0009887 ! animal organ morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0000020 ! sense organ
relationship: part_of GO:0007423 ! sensory organ development
relationship: results_in_morphogenesis_of UBERON:0000020 ! sense organ
created_by: tb
creation_date: 2014-08-22T13:23:20Z

[Term]
id: GO:0090598
name: male anatomical structure morphogenesis
namespace: biological_process
def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0014403 ! male anatomical structure
relationship: part_of GO:0046661 ! male sex differentiation
relationship: results_in_morphogenesis_of UBERON:0014403 ! male anatomical structure
created_by: tb
creation_date: 2014-08-22T13:29:45Z

[Term]
id: GO:0090685
name: RNA localization to nucleus
namespace: biological_process
def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931]
synonym: "RNA localisation to nucleus" EXACT [GOC:mah]
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: has_target_end_location GO:0005634 ! nucleus
relationship: has_target_end_location GO:0005634 ! nucleus
created_by: tb
creation_date: 2016-07-19T17:00:49Z

[Term]
id: GO:0090741
name: pigment granule membrane
namespace: cellular_component
def: "Any membrane that is part of a pigment granule." [PMID:11294610]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
is_a: GO:0098588 ! bounding membrane of organelle
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0048770 ! pigment granule
relationship: bounding_layer_of GO:0048770 ! pigment granule
relationship: part_of GO:0048770 ! pigment granule
created_by: tb
creation_date: 2017-05-16T22:33:39Z

[Term]
id: GO:0097014
name: ciliary plasm
namespace: cellular_component
def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]
comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm".
synonym: "cilial cytoplasm" RELATED []
synonym: "ciliary cytoplasm" RELATED []
synonym: "cilium cytoplasm" RELATED []
synonym: "cilium plasm" EXACT []
synonym: "microtubule-based flagellar cytoplasm" RELATED []
synonym: "microtubule-based flagellar matrix" NARROW []
synonym: "microtubule-based flagellum cytoplasm" RELATED []
synonym: "microtubule-based flagellum matrix" NARROW []
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0005929 ! cilium
relationship: part_of GO:0005929 ! cilium
created_by: pr
creation_date: 2011-03-23T01:52:31Z

[Term]
id: GO:0097026
name: dendritic cell dendrite assembly
namespace: biological_process
def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351]
comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals.
synonym: "dendritic extension" BROAD []
is_a: GO:0120031 ! plasma membrane bounded cell projection assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0097511 ! dendritic cell dendrite
relationship: results_in_assembly_of GO:0097511 ! dendritic cell dendrite
created_by: pr
creation_date: 2011-03-31T04:52:53Z

[Term]
id: GO:0097028
name: dendritic cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:1903131 ! mononuclear cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000451 ! dendritic cell
relationship: results_in_acquisition_of_features_of CL:0000451 ! dendritic cell
created_by: pr
creation_date: 2011-04-01T10:08:42Z

[Term]
id: GO:0097048
name: dendritic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845]
synonym: "dendritic cell apoptosis" NARROW []
is_a: GO:0071887 ! leukocyte apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000451 ! dendritic cell
relationship: occurs_in CL:0000451 ! dendritic cell
created_by: pr
creation_date: 2011-05-04T02:18:59Z

[Term]
id: GO:0097049
name: motor neuron apoptotic process
namespace: biological_process
def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086]
synonym: "motoneuron apoptosis" EXACT []
synonym: "motor neuron apoptosis" NARROW []
is_a: GO:0051402 ! neuron apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000100 ! motor neuron
relationship: occurs_in CL:0000100 ! motor neuron
created_by: pr
creation_date: 2011-05-04T02:21:43Z

[Term]
id: GO:0097050
name: type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305]
synonym: "pancreatic B cell apoptosis" EXACT []
synonym: "pancreatic beta cell apoptosis" EXACT []
synonym: "type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000169 ! type B pancreatic cell
relationship: occurs_in CL:0000169 ! type B pancreatic cell
created_by: pr
creation_date: 2011-05-04T02:24:38Z

[Term]
id: GO:0097060
name: synaptic membrane
namespace: cellular_component
def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]
subset: goslim_synapse
is_a: GO:0098590 ! plasma membrane region
intersection_of: GO:0098590 ! plasma membrane region
intersection_of: part_of GO:0045202 ! synapse
relationship: part_of GO:0045202 ! synapse
created_by: pr
creation_date: 2011-06-07T11:22:09Z

[Term]
id: GO:0097084
name: vascular associated smooth muscle cell development
namespace: biological_process
def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF]
synonym: "vascular smooth muscle cell development" EXACT []
is_a: GO:0055001 ! muscle cell development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of CL:0000359 ! vascular associated smooth muscle cell
relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: results_in_development_of CL:0000359 ! vascular associated smooth muscle cell
created_by: pr
creation_date: 2011-06-20T04:03:08Z

[Term]
id: GO:0097152
name: mesenchymal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833]
synonym: "mesenchymal cell apoptosis" NARROW []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0008019 ! mesenchymal cell
relationship: occurs_in CL:0008019 ! mesenchymal cell
created_by: pr
creation_date: 2011-09-06T02:31:59Z

[Term]
id: GO:0097164
name: ammonium ion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018]
synonym: "ammonium ion metabolism" EXACT []
synonym: "ammonium metabolic process" RELATED []
is_a: GO:0006807 ! nitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:28938 ! ammonium
relationship: has_primary_input_or_output CHEBI:28938 ! ammonium
created_by: pr
creation_date: 2011-09-28T04:21:30Z

[Term]
id: GO:0097190
name: apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008624
def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
synonym: "apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "induction of apoptosis by extracellular signals" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2011-11-23T09:30:23Z

[Term]
id: GO:0097194
name: execution phase of apoptosis
namespace: biological_process
def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]
synonym: "apoptosis" NARROW []
synonym: "execution phase of apoptotic process" EXACT []
is_a: GO:0009987 ! cellular process
relationship: has_part GO:0032060 ! bleb assembly
relationship: part_of GO:0006915 ! apoptotic process
created_by: pr
creation_date: 2011-11-23T09:45:24Z

[Term]
id: GO:0097237
name: cellular response to toxic substance
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr]
created_by: pr
creation_date: 2012-02-02T12:23:31Z

[Term]
id: GO:0097254
name: renal tubular secretion
namespace: biological_process
def: "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI
created_by: pr
creation_date: 2012-03-05T02:03:58Z

[Term]
id: GO:0097284
name: hepatocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020]
synonym: "hepatocyte apoptosis" NARROW []
is_a: GO:1904019 ! epithelial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000182 ! hepatocyte
relationship: occurs_in CL:0000182 ! hepatocyte
created_by: pr
creation_date: 2012-03-29T10:23:21Z

[Term]
id: GO:0097355
name: protein localization to heterochromatin
namespace: biological_process
def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah]
synonym: "protein localisation to heterochromatin" EXACT [GOC:mah]
is_a: GO:0071168 ! protein localization to chromatin
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0000792 ! heterochromatin
relationship: has_target_end_location GO:0000792 ! heterochromatin
created_by: pr
creation_date: 2012-07-03T03:19:07Z

[Term]
id: GO:0097360
name: chorionic trophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278]
is_a: GO:0008283 ! cell population proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0011101 ! chorionic trophoblast cell
relationship: acts_on_population_of CL:0011101 ! chorionic trophoblast cell
created_by: pr
creation_date: 2012-07-19T10:17:37Z

[Term]
id: GO:0097386
name: glial cell projection
namespace: cellular_component
def: "A prolongation or process extending from a glial cell." [GOC:mc]
synonym: "glial process" RELATED []
synonym: "glial projection" RELATED []
is_a: GO:0120025 ! plasma membrane bounded cell projection
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: part_of CL:0000125 ! glial cell
relationship: part_of CL:0000125 ! glial cell
created_by: pr
creation_date: 2012-10-22T13:55:54Z

[Term]
id: GO:0097402
name: neuroblast migration
namespace: biological_process
def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: results_in_movement_of CL:0000031 ! neuroblast (sensu Vertebrata)
created_by: pr
creation_date: 2012-10-29T08:24:37Z

[Term]
id: GO:0097427
name: microtubule bundle
namespace: cellular_component
def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973]
synonym: "microtubule fascicle" EXACT []
xref: NIF_Subcellular:sao1872343973
is_a: GO:0110165 ! cellular anatomical entity
relationship: has_part GO:0005874 ! microtubule
relationship: part_of GO:0005856 ! cytoskeleton
created_by: pr
creation_date: 2012-11-07T15:01:27Z

[Term]
id: GO:0097435
name: supramolecular fiber organization
namespace: biological_process
alt_id: GO:0043206
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]
synonym: "extracellular fibril organisation" NARROW []
synonym: "extracellular fibril organization" NARROW []
synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah]
synonym: "fibril organisation" RELATED []
synonym: "fibril organization" RELATED []
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0099512 ! supramolecular fiber
relationship: results_in_organization_of GO:0099512 ! supramolecular fiber
created_by: pr
creation_date: 2012-11-27T15:46:25Z

[Term]
id: GO:0097473
name: retinal rod cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487]
synonym: "rod photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000604 ! retinal rod cell
relationship: occurs_in CL:0000604 ! retinal rod cell
created_by: pr
creation_date: 2013-03-21T09:44:45Z

[Term]
id: GO:0097474
name: retinal cone cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc]
synonym: "cone photoreceptor apoptotic process" EXACT []
is_a: GO:0051402 ! neuron apoptotic process
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000573 ! retinal cone cell
relationship: occurs_in CL:0000573 ! retinal cone cell
created_by: pr
creation_date: 2013-03-21T09:46:22Z

[Term]
id: GO:0097475
name: motor neuron migration
namespace: biological_process
def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000100 ! motor neuron
relationship: results_in_movement_of CL:0000100 ! motor neuron
created_by: pr
creation_date: 2013-04-23T13:00:46Z

[Term]
id: GO:0097476
name: spinal cord motor neuron migration
namespace: biological_process
def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475]
is_a: GO:0097475 ! motor neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0011001 ! spinal cord motor neuron
relationship: results_in_movement_of CL:0011001 ! spinal cord motor neuron
created_by: pr
creation_date: 2013-04-23T13:03:46Z

[Term]
id: GO:0097511
name: dendritic cell dendrite
namespace: cellular_component
def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351]
is_a: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: GO:0120025 ! plasma membrane bounded cell projection
intersection_of: part_of CL:0000451 ! dendritic cell
relationship: part_of CL:0000451 ! dendritic cell
created_by: pr
creation_date: 2013-10-16T13:02:25Z

[Term]
id: GO:0097512
name: cardiac myofibril
namespace: cellular_component
def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol]
is_a: GO:0030016 ! myofibril
intersection_of: GO:0030016 ! myofibril
intersection_of: part_of CL:0000746 ! cardiac muscle cell
relationship: part_of CL:0000746 ! cardiac muscle cell
created_by: pr
creation_date: 2013-10-16T13:04:58Z

[Term]
id: GO:0097524
name: sperm plasma membrane
namespace: cellular_component
def: "A plasma membrane that is part of a sperm cell." [GOC:cjm]
is_a: GO:0005886 ! plasma membrane
intersection_of: GO:0005886 ! plasma membrane
intersection_of: part_of CL:0000019 ! sperm
relationship: part_of CL:0000019 ! sperm
created_by: pr
creation_date: 2013-10-18T11:31:17Z

[Term]
id: GO:0097529
name: myeloid leukocyte migration
namespace: biological_process
def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461]
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000766 ! myeloid leukocyte
relationship: results_in_movement_of CL:0000766 ! myeloid leukocyte
created_by: pr
creation_date: 2013-11-11T13:59:43Z

[Term]
id: GO:0097534
name: lymphoid lineage cell migration
namespace: biological_process
def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843]
synonym: "lymphoid lineage restricted progenitor cell migration" EXACT []
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000838 ! lymphoid lineage restricted progenitor cell
relationship: results_in_movement_of CL:0000838 ! lymphoid lineage restricted progenitor cell
created_by: pr
creation_date: 2013-11-28T10:47:15Z

[Term]
id: GO:0097576
name: vacuole fusion
namespace: biological_process
def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048284 ! organelle fusion
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_fusion_of GO:0005773 ! vacuole
relationship: results_in_fusion_of GO:0005773 ! vacuole
created_by: pr
creation_date: 2014-02-28T09:49:31Z

[Term]
id: GO:0097708
name: intracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the intracellular region." [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005622 ! intracellular anatomical structure
created_by: pr
creation_date: 2016-03-29T17:39:45Z

[Term]
id: GO:0097711
name: ciliary basal body-plasma membrane docking
namespace: biological_process
def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235, Reactome:R-HSA-5620912.1]
comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella.
synonym: "anchoring of the basal body to the plasma membrane" RELATED []
synonym: "ciliary basal body docking" EXACT []
xref: Reactome:R-HSA-5620912.1
is_a: GO:0140056 ! organelle localization by membrane tethering
relationship: part_of GO:0060271 ! cilium assembly
created_by: pr
creation_date: 2016-08-05T16:12:33Z

[Term]
id: GO:0097712
name: vesicle targeting, trans-Golgi to periciliary membrane compartment
namespace: biological_process
def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1]
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0060271 ! cilium assembly
created_by: pr
creation_date: 2016-08-05T16:16:28Z

[Term]
id: GO:0097722
name: sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc]
subset: gocheck_do_not_annotate
synonym: "sperm movement" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: results_in_movement_of CL:0000019 ! sperm
relationship: results_in_movement_of CL:0000019 ! sperm
created_by: pr
creation_date: 2016-09-01T12:00:45Z

[Term]
id: GO:0097734
name: extracellular exosome biogenesis
namespace: biological_process
def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495]
synonym: "exosome assembly or secretion" EXACT []
synonym: "exosome biogenesis" EXACT []
synonym: "exosome production" EXACT []
synonym: "ILV assembly" RELATED []
synonym: "intraluminal vesicle assembly" RELATED []
is_a: GO:0140112 ! extracellular vesicle biogenesis
created_by: pr
creation_date: 2016-10-03T14:35:25Z

[Term]
id: GO:0098523
name: neuromuscular junction of myotube
namespace: cellular_component
def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos]
comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes.
is_a: GO:0031594 ! neuromuscular junction
intersection_of: GO:0045202 ! synapse
intersection_of: overlaps CL:0000100 ! motor neuron
intersection_of: overlaps CL:0002372 ! myotube
relationship: overlaps CL:0002372 ! myotube
created_by: dos
creation_date: 2013-10-14T12:05:12Z

[Term]
id: GO:0098528
name: skeletal muscle fiber differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos]
is_a: GO:0014902 ! myotube differentiation
is_a: GO:0035914 ! skeletal muscle cell differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0008002 ! skeletal muscle fiber
relationship: results_in_acquisition_of_features_of CL:0008002 ! skeletal muscle fiber
created_by: dos
creation_date: 2013-10-15T14:00:34Z

[Term]
id: GO:0098542
name: defense response to other organism
namespace: biological_process
alt_id: GO:0009814
def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]
subset: goslim_generic
subset: goslim_prokaryote
synonym: "defence response incompatible interaction" NARROW []
synonym: "defence response to pathogen, incompatible interaction" NARROW []
synonym: "defense response, incompatible interaction" NARROW []
synonym: "resistance response to pathogen" NARROW []
is_a: GO:0006952 ! defense response
is_a: GO:0051707 ! response to other organism
intersection_of: GO:0006952 ! defense response
intersection_of: has_primary_input NCBITaxon_Union:0000030
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22173" xsd:anyURI
created_by: dos
creation_date: 2013-11-11T12:59:11Z

[Term]
id: GO:0098588
name: bounding membrane of organelle
namespace: cellular_component
def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]
comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.
is_a: GO:0031090 ! organelle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0043226 ! organelle
relationship: bounding_layer_of GO:0043226 ! organelle
created_by: dos
creation_date: 2014-02-26T13:41:31Z

[Term]
id: GO:0098590
name: plasma membrane region
namespace: cellular_component
def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos]
comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass.
subset: gocheck_do_not_manually_annotate
synonym: "region of plasma membrane" EXACT []
is_a: GO:0016020 ! membrane
intersection_of: GO:0016020 ! membrane
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane
created_by: dos
creation_date: 2014-03-06T11:55:32Z

[Term]
id: GO:0098609
name: cell-cell adhesion
namespace: biological_process
alt_id: GO:0016337
def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos]
synonym: "single organismal cell-cell adhesion" RELATED []
is_a: GO:0007155 ! cell adhesion
created_by: dos
creation_date: 2014-04-16T13:40:03Z

[Term]
id: GO:0098635
name: protein complex involved in cell-cell adhesion
namespace: cellular_component
def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos]
is_a: GO:0098636 ! protein complex involved in cell adhesion
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of_part_of GO:0098609 ! cell-cell adhesion
relationship: capable_of_part_of GO:0098609 ! cell-cell adhesion

[Term]
id: GO:0098636
name: protein complex involved in cell adhesion
namespace: cellular_component
alt_id: GO:1990307
def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos]
synonym: "cell adhesion complex" RELATED []
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of_part_of GO:0007155 ! cell adhesion
relationship: capable_of_part_of GO:0007155 ! cell adhesion

[Term]
id: GO:0098642
name: network-forming collagen trimer
namespace: cellular_component
def: "A collagen trimer that forms networks." [PMID:21421911]
is_a: GO:0005581 ! collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0098645 ! collagen network
relationship: part_of GO:0098645 ! collagen network

[Term]
id: GO:0098643
name: banded collagen fibril
namespace: cellular_component
def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers
is_a: GO:0099512 ! supramolecular fiber

[Term]
id: GO:0098644
name: complex of collagen trimers
namespace: cellular_component
def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos]
synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541]
synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911]
is_a: GO:0099080 ! supramolecular complex
is_a: PR:000050567 ! protein-containing material entity
relationship: has_part GO:0005581 ! collagen trimer
relationship: part_of GO:0062023 ! collagen-containing extracellular matrix

[Term]
id: GO:0098645
name: collagen network
namespace: cellular_component
def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911]
is_a: GO:0098644 ! complex of collagen trimers
is_a: GO:0099081 ! supramolecular polymer

[Term]
id: GO:0098651
name: basement membrane collagen trimer
namespace: cellular_component
def: "Any collagen timer that is part of a basement membrane." [GOC:dos, PMID:21421911]
is_a: GO:0005581 ! collagen trimer
intersection_of: GO:0005581 ! collagen trimer
intersection_of: part_of GO:0005604 ! basement membrane
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0098655
name: monoatomic cation transmembrane transport
namespace: biological_process
alt_id: GO:0099132
def: "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]
synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW []
synonym: "cation transmembrane transport" BROAD []
is_a: GO:0006812 ! monoatomic cation transport
is_a: GO:0034220 ! monoatomic ion transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:23906 ! monoatomic cation
intersection_of: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0098657
name: import into cell
namespace: biological_process
def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]
synonym: "uptake" BROAD []
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:24431 ! chemical entity
intersection_of: has_target_end_location GO:0005737 ! cytoplasm
intersection_of: has_target_start_location GO:0005576 ! extracellular region
relationship: has_primary_input CHEBI:24431 ! chemical entity
relationship: has_target_end_location GO:0005737 ! cytoplasm
relationship: has_target_start_location GO:0005576 ! extracellular region

[Term]
id: GO:0098660
name: inorganic ion transmembrane transport
namespace: biological_process
def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic ion membrane transport" EXACT []
synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:36914 ! inorganic ion
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:36914 ! inorganic ion

[Term]
id: GO:0098661
name: inorganic anion transmembrane transport
namespace: biological_process
def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "inorganic anion membrane transport" EXACT []
synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0098660 ! inorganic ion transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:24834 ! inorganic anion
intersection_of: results_in_transport_across GO:0016020 ! membrane

[Term]
id: GO:0098662
name: inorganic cation transmembrane transport
namespace: biological_process
alt_id: GO:0015672
alt_id: GO:0072511
def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]
comment: Note that this term is not intended for use in annotating lateral movement within membranes.
synonym: "divalent inorganic cation transport" NARROW []
synonym: "inorganic cation membrane transport" EXACT []
synonym: "monovalent inorganic cation transport" NARROW []
synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0098660 ! inorganic ion transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:36915 ! inorganic cation
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:36915 ! inorganic cation

[Term]
id: GO:0098722
name: asymmetric stem cell division
namespace: biological_process
def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950]
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0017145 ! stem cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: has_primary_input CL:0000034 ! stem cell

[Term]
id: GO:0098723
name: skeletal muscle myofibril
namespace: cellular_component
def: "A myofibril of a skeletal muscle fiber." [GOC:dos]
is_a: GO:0030016 ! myofibril
intersection_of: GO:0030016 ! myofibril
intersection_of: part_of CL:0008002 ! skeletal muscle fiber
relationship: part_of CL:0008002 ! skeletal muscle fiber

[Term]
id: GO:0098727
name: maintenance of cell number
namespace: biological_process
def: "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0098728
name: germline stem cell asymmetric division
namespace: biological_process
def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos]
is_a: GO:0042078 ! germ-line stem cell division
is_a: GO:0098722 ! asymmetric stem cell division
intersection_of: GO:0008356 ! asymmetric cell division
intersection_of: has_primary_input CL:0000014 ! germ line stem cell

[Term]
id: GO:0098751
name: bone cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos]
comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development.
subset: gocheck_do_not_annotate
is_a: GO:0048468 ! cell development
intersection_of: GO:0032502 ! developmental process
intersection_of: results_in_development_of CL:0001035 ! bone cell
relationship: part_of GO:0060348 ! bone development
relationship: results_in_development_of CL:0001035 ! bone cell

[Term]
id: GO:0098754
name: detoxification
namespace: biological_process
def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos]
subset: goslim_generic
subset: goslim_pombe
subset: goslim_prokaryote
is_a: GO:0008150 ! biological process
relationship: part_of GO:0009636 ! response to toxic substance

[Term]
id: GO:0098773
name: skin epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos]
is_a: GO:0008544 ! epidermis development
is_a: GO:0060429 ! epithelium development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001003 ! skin epidermis
relationship: part_of GO:0043588 ! skin development
relationship: results_in_development_of UBERON:0001003 ! skin epidermis

[Term]
id: GO:0098793
name: presynapse
namespace: cellular_component
def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic terminal" EXACT []
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000540 ! neuron
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098794
name: postsynapse
namespace: cellular_component
def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos]
subset: goslim_synapse
is_a: GO:0110165 ! cellular anatomical entity
relationship: part_of CL:0000000 ! cell
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0098796
name: membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of a membrane." [GOC:dos]
subset: goslim_metagenomics
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: part_of GO:0016020 ! membrane
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0098797
name: plasma membrane protein complex
namespace: cellular_component
def: "Any protein complex that is part of the plasma membrane." [GOC:dos]
is_a: GO:0098796 ! membrane protein complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0098801
name: regulation of renal system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003014 ! renal system process
relationship: regulates GO:0003014 ! renal system process

[Term]
id: GO:0098813
name: nuclear chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos]
is_a: GO:0007059 ! chromosome segregation

[Term]
id: GO:0098840
name: protein transport along microtubule
namespace: biological_process
def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607]
synonym: "microtubule-based protein transport" BROAD []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0010970 ! transport along microtubule
is_a: GO:0099118 ! microtubule-based protein transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: results_in_transport_along GO:0005874 ! microtubule

[Term]
id: GO:0098858
name: actin-based cell projection
namespace: cellular_component
def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]
is_a: GO:0120025 ! plasma membrane bounded cell projection
relationship: has_part GO:0005884 ! actin filament

[Term]
id: GO:0098867
name: intramembranous bone growth
namespace: biological_process
def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686]
is_a: GO:0098868 ! bone growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0002514 ! intramembranous bone
relationship: results_in_growth_of UBERON:0002514 ! intramembranous bone

[Term]
id: GO:0098868
name: bone growth
namespace: biological_process
def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos]
is_a: GO:0035265 ! organ growth
intersection_of: GO:0048589 ! developmental growth
intersection_of: results_in_growth_of UBERON:0001474 ! bone element
relationship: part_of GO:0060348 ! bone development
relationship: results_in_growth_of UBERON:0001474 ! bone element

[Term]
id: GO:0098871
name: postsynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099571 ! postsynaptic cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0098876
name: vesicle-mediated transport to the plasma membrane
namespace: biological_process
def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0051668 ! localization within membrane
intersection_of: GO:0006810 ! transport
intersection_of: has_target_end_location GO:0005886 ! plasma membrane
intersection_of: process_has_causal_agent GO:0031982 ! vesicle
relationship: ends_with GO:0006887 ! exocytosis
relationship: has_target_end_location GO:0005886 ! plasma membrane

[Term]
id: GO:0098883
name: synapse pruning
namespace: biological_process
def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190]
subset: goslim_synapse
synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020]
synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190]
synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716]
is_a: GO:0050808 ! synapse organization
is_a: GO:0150146 ! cell junction disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0045202 ! synapse
relationship: results_in_disassembly_of GO:0045202 ! synapse

[Term]
id: GO:0098900
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]
comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term.
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0001508 ! action potential
relationship: regulates GO:0001508 ! action potential

[Term]
id: GO:0098901
name: regulation of cardiac muscle cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086001 ! cardiac muscle cell action potential
relationship: regulates GO:0086001 ! cardiac muscle cell action potential

[Term]
id: GO:0098904
name: regulation of AV node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT []
synonym: "regulation of AV node cardiac muscle cell action potential" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086016 ! AV node cell action potential
relationship: regulates GO:0086016 ! AV node cell action potential
created_by: tb
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098906
name: regulation of Purkinje myocyte action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086017 ! Purkinje myocyte action potential
relationship: regulates GO:0086017 ! Purkinje myocyte action potential
created_by: tb
creation_date: 2011-11-10T08:58:56Z

[Term]
id: GO:0098907
name: regulation of SA node cell action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
synonym: "regulation of SA node cardiac muscle cell action potential" EXACT []
synonym: "regulation of SAN cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT []
synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0098901 ! regulation of cardiac muscle cell action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0086015 ! SA node cell action potential
relationship: regulates GO:0086015 ! SA node cell action potential
created_by: tb
creation_date: 2011-11-10T08:50:15Z

[Term]
id: GO:0098908
name: regulation of neuronal action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051969 ! regulation of transmission of nerve impulse
is_a: GO:0098900 ! regulation of action potential
intersection_of: GO:0050789 ! regulation of biological process
intersection_of: regulates GO:0019228 ! neuronal action potential
relationship: regulates GO:0019228 ! neuronal action potential

[Term]
id: GO:0098916
name: anterograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: has_end_location GO:0098794 ! postsynapse
intersection_of: has_start_location GO:0098793 ! presynapse
relationship: has_end_location GO:0098794 ! postsynapse
relationship: has_start_location GO:0098793 ! presynapse

[Term]
id: GO:0098917
name: retrograde trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos]
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: has_end_location GO:0098793 ! presynapse
intersection_of: has_start_location GO:0098794 ! postsynapse
relationship: has_end_location GO:0098793 ! presynapse
relationship: has_start_location GO:0098794 ! postsynapse

[Term]
id: GO:0098920
name: retrograde trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099541 ! trans-synaptic signaling by lipid
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: has_end_location GO:0098793 ! presynapse
intersection_of: has_start_location GO:0098794 ! postsynapse
intersection_of: process_has_causal_agent CHEBI:18059 ! lipid

[Term]
id: GO:0098926
name: postsynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynaptic signaling pathway" EXACT syngo_official_label []
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: has_start_location GO:0098794 ! postsynapse
relationship: has_start_location GO:0098794 ! postsynapse
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0098928
name: presynaptic signal transduction
namespace: biological_process
def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynaptic signaling pathway" EXACT syngo_official_label []
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: has_start_location GO:0098793 ! presynapse
relationship: has_start_location GO:0098793 ! presynapse

[Term]
id: GO:0098974
name: postsynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099188 ! postsynaptic cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0098871 ! postsynaptic actin cytoskeleton
relationship: results_in_organization_of GO:0098871 ! postsynaptic actin cytoskeleton

[Term]
id: GO:0098975
name: postsynapse of neuromuscular junction
namespace: cellular_component
def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502]
is_a: GO:0098794 ! postsynapse
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: GO:0098794 ! postsynapse
intersection_of: part_of CL:0000187 ! muscle cell
intersection_of: part_of GO:0031594 ! neuromuscular junction
relationship: part_of CL:0000187 ! muscle cell
relationship: part_of GO:0031594 ! neuromuscular junction

[Term]
id: GO:0098981
name: cholinergic synapse
namespace: cellular_component
def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos]
subset: goslim_synapse
is_a: GO:0045202 ! synapse
intersection_of: GO:0045202 ! synapse
intersection_of: capable_of GO:0007271 ! synaptic transmission, cholinergic
relationship: capable_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0098992
name: neuronal dense core vesicle
namespace: cellular_component
def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]
subset: goslim_synapse
is_a: GO:0031045 ! dense core granule
intersection_of: GO:0031045 ! dense core granule
intersection_of: part_of CL:0000540 ! neuron
relationship: part_of CL:0000540 ! neuron

[Term]
id: GO:0099003
name: vesicle-mediated transport in synapse
namespace: biological_process
def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0016192 ! vesicle-mediated transport
intersection_of: occurs_in GO:0045202 ! synapse
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0099012
name: neuronal dense core vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos]
subset: goslim_synapse
is_a: GO:0032127 ! dense core granule membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0098992 ! neuronal dense core vesicle
relationship: bounding_layer_of GO:0098992 ! neuronal dense core vesicle
relationship: part_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099014
name: neuronal dense core vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos]
is_a: GO:0061109 ! dense core granule organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0098992 ! neuronal dense core vesicle
relationship: results_in_organization_of GO:0098992 ! neuronal dense core vesicle

[Term]
id: GO:0099054
name: presynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
subset: goslim_synapse
synonym: "presynapse biogenesis" EXACT [GOC:mah]
synonym: "presynaptic terminal assembly" EXACT [PMID:24449494]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099172 ! presynapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_assembly_of GO:0098793 ! presynapse
relationship: part_of GO:0007416 ! synapse assembly
relationship: results_in_assembly_of GO:0098793 ! presynapse

[Term]
id: GO:0099068
name: postsynapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL]
synonym: "postsynapse biogenesis" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0099173 ! postsynapse organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_assembly_of GO:0098794 ! postsynapse
relationship: part_of GO:0007416 ! synapse assembly
relationship: results_in_assembly_of GO:0098794 ! postsynapse

[Term]
id: GO:0099080
name: supramolecular complex
namespace: cellular_component
def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]
is_a: GO:0110165 ! cellular anatomical entity

[Term]
id: GO:0099081
name: supramolecular polymer
namespace: cellular_component
def: "A polymeric supramolecular structure." [GOC:dos]
is_a: GO:0099080 ! supramolecular complex
intersection_of: GO:0099080 ! supramolecular complex
intersection_of: has_characteristic PATO:0015006 ! polymeric
relationship: has_characteristic PATO:0015006 ! polymeric

[Term]
id: GO:0099082
name: retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
subset: goslim_synapse
is_a: GO:0098917 ! retrograde trans-synaptic signaling
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: has_end_location GO:0098793 ! presynapse
intersection_of: has_start_location GO:0098794 ! postsynapse
intersection_of: process_has_causal_agent CHEBI:16670 ! peptide

[Term]
id: GO:0099083
name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: has_end_location GO:0098793 ! presynapse
intersection_of: has_start_location GO:0098794 ! postsynapse
intersection_of: process_has_causal_agent CHEBI:16670 ! peptide
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099098
name: microtubule polymerization based movement
namespace: biological_process
def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194]
is_a: GO:0007018 ! microtubule-based movement
intersection_of: GO:0007018 ! microtubule-based movement
intersection_of: has_part GO:0046785 ! microtubule polymerization
relationship: has_part GO:0046785 ! microtubule polymerization

[Term]
id: GO:0099111
name: microtubule-based transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]
is_a: GO:0006810 ! transport
intersection_of: GO:0006810 ! transport
intersection_of: process_has_causal_agent GO:0005874 ! microtubule
relationship: process_has_causal_agent GO:0005874 ! microtubule

[Term]
id: GO:0099112
name: microtubule polymerization based protein transport
namespace: biological_process
def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0045184 ! establishment of protein localization
is_a: GO:0046907 ! intracellular transport
is_a: GO:0071702 ! organic substance transport
is_a: GO:0099111 ! microtubule-based transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_part GO:0046785 ! microtubule polymerization
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: process_has_causal_agent GO:0005874 ! microtubule
relationship: has_part GO:0046785 ! microtubule polymerization

[Term]
id: GO:0099118
name: microtubule-based protein transport
namespace: biological_process
def: "A microtubule-based process that results in the transport of proteins." [GOC:vw]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0015031 ! protein transport
is_a: GO:0099111 ! microtubule-based transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: process_has_causal_agent GO:0005874 ! microtubule

[Term]
id: GO:0099140
name: presynaptic actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0099187 ! presynaptic cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0099143 ! presynaptic actin cytoskeleton
relationship: results_in_organization_of GO:0099143 ! presynaptic actin cytoskeleton
created_by: dos
creation_date: 2017-06-09T18:34:19Z

[Term]
id: GO:0099143
name: presynaptic actin cytoskeleton
namespace: cellular_component
def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0015629 ! actin cytoskeleton
is_a: GO:0099569 ! presynaptic cytoskeleton
intersection_of: GO:0015629 ! actin cytoskeleton
intersection_of: part_of GO:0098793 ! presynapse
created_by: dos
creation_date: 2017-06-09T18:36:19Z

[Term]
id: GO:0099156
name: cell-cell signaling via exosome
namespace: biological_process
def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038]
synonym: "exosome mediated" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: process_has_causal_agent GO:0070062 ! extracellular exosome
relationship: process_has_causal_agent GO:0070062 ! extracellular exosome
created_by: dos
creation_date: 2017-07-05T16:40:45Z

[Term]
id: GO:0099157
name: trans-synaptic signaling via exosome
namespace: biological_process
def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038]
subset: goslim_synapse
synonym: "exosome mediated transynaptic signalling" EXACT []
synonym: "trans-synaptic signalling via exosome" EXACT []
is_a: GO:0099156 ! cell-cell signaling via exosome
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: process_has_causal_agent GO:0070062 ! extracellular exosome
created_by: dos
creation_date: 2017-07-05T16:49:44Z

[Term]
id: GO:0099170
name: postsynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse
created_by: dos
creation_date: 2017-09-11T17:09:17Z

[Term]
id: GO:0099171
name: presynaptic modulation of chemical synaptic transmission
namespace: biological_process
def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos]
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse
created_by: dos
creation_date: 2017-09-11T17:09:31Z

[Term]
id: GO:0099172
name: presynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos]
subset: goslim_synapse
synonym: "presynapse development" EXACT []
synonym: "presynapse morphogenesis" RELATED [GOC:BHF]
synonym: "presynapse organisation" EXACT []
synonym: "presynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_organization_of GO:0098793 ! presynapse
relationship: part_of GO:0050808 ! synapse organization
relationship: results_in_organization_of GO:0098793 ! presynapse

[Term]
id: GO:0099173
name: postsynapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos]
subset: goslim_synapse
synonym: "postsynapse development" EXACT []
synonym: "postsynapse morphogenesis" RELATED [GOC:BHF]
synonym: "postsynapse organisation" EXACT []
synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_organization_of GO:0098794 ! postsynapse
relationship: part_of GO:0050808 ! synapse organization
relationship: results_in_organization_of GO:0098794 ! postsynapse

[Term]
id: GO:0099174
name: regulation of presynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of presynapse organisation" EXACT [GOC:mah]
synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of presynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099172 ! presynapse organization
relationship: regulates GO:0099172 ! presynapse organization

[Term]
id: GO:0099175
name: regulation of postsynapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_synapse
synonym: "regulation of postsynapse organisation" EXACT [GOC:mah]
synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of postsynapse structure" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099173 ! postsynapse organization
relationship: regulates GO:0099173 ! postsynapse organization

[Term]
id: GO:0099177
name: regulation of trans-synaptic signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099537 ! trans-synaptic signaling
relationship: regulates GO:0099537 ! trans-synaptic signaling

[Term]
id: GO:0099187
name: presynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos]
is_a: GO:0007010 ! cytoskeleton organization
intersection_of: GO:0009987 ! cellular process
intersection_of: results_in_organization_of GO:0099569 ! presynaptic cytoskeleton
relationship: part_of GO:0099172 ! presynapse organization
relationship: results_in_organization_of GO:0099569 ! presynaptic cytoskeleton
created_by: dos
creation_date: 2017-12-20T15:05:34Z

[Term]
id: GO:0099188
name: postsynaptic cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]
subset: goslim_synapse
is_a: GO:0007010 ! cytoskeleton organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0099571 ! postsynaptic cytoskeleton
relationship: part_of GO:0099173 ! postsynapse organization
relationship: results_in_organization_of GO:0099571 ! postsynaptic cytoskeleton
created_by: dos
creation_date: 2017-12-20T15:06:57Z

[Term]
id: GO:0099500
name: vesicle fusion to plasma membrane
namespace: biological_process
def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0140029 ! exocytic process
intersection_of: GO:0061025 ! membrane fusion
intersection_of: part_of GO:0006887 ! exocytosis
intersection_of: results_in_fusion_of GO:0012506 ! vesicle membrane
intersection_of: results_in_fusion_of GO:0098590 ! plasma membrane region
relationship: results_in_fusion_of GO:0098590 ! plasma membrane region

[Term]
id: GO:0099501
name: exocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030658 ! transport vesicle membrane
intersection_of: GO:0016020 ! membrane
intersection_of: bounding_layer_of GO:0070382 ! exocytic vesicle
relationship: bounding_layer_of GO:0070382 ! exocytic vesicle
relationship: part_of GO:0070382 ! exocytic vesicle

[Term]
id: GO:0099503
name: secretory vesicle
namespace: cellular_component
def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]
subset: goslim_drosophila
is_a: GO:0031410 ! cytoplasmic vesicle
intersection_of: GO:0031982 ! vesicle
intersection_of: capable_of GO:0099500 ! vesicle fusion to plasma membrane
relationship: capable_of GO:0099500 ! vesicle fusion to plasma membrane

[Term]
id: GO:0099512
name: supramolecular fiber
namespace: cellular_component
alt_id: GO:0043205
def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos]
synonym: "fibril" RELATED []
is_a: GO:0099081 ! supramolecular polymer
intersection_of: GO:0099080 ! supramolecular complex
intersection_of: has_characteristic PATO:0002309 ! fiber shaped
intersection_of: has_characteristic PATO:0015006 ! polymeric
relationship: has_characteristic PATO:0002309 ! fiber shaped

[Term]
id: GO:0099513
name: polymeric cytoskeletal fiber
namespace: cellular_component
def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos]
is_a: GO:0099512 ! supramolecular fiber
intersection_of: GO:0099512 ! supramolecular fiber
intersection_of: has_characteristic PATO:0015006 ! polymeric
intersection_of: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0099515
name: actin filament-based transport
namespace: biological_process
def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
intersection_of: GO:0046907 ! intracellular transport
intersection_of: results_in_transport_along GO:0005884 ! actin filament
relationship: results_in_transport_along GO:0005884 ! actin filament
created_by: tb
creation_date: 2009-05-27T10:56:08Z

[Term]
id: GO:0099518
name: vesicle cytoskeletal trafficking
namespace: biological_process
def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]
synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl]
synonym: "vesicle cytoskeletal transport" EXACT []
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport
is_a: GO:0051650 ! establishment of vesicle localization
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input GO:0031982 ! vesicle
intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber

[Term]
id: GO:0099531
name: presynaptic process involved in chemical synaptic transmission
namespace: biological_process
def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos]
subset: gocheck_do_not_annotate
subset: goslim_synapse
is_a: GO:0050877 ! nervous system process
intersection_of: GO:0050877 ! nervous system process
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: part_of GO:0007268 ! chemical synaptic transmission
relationship: occurs_in GO:0098793 ! presynapse
relationship: part_of GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099536
name: synaptic signaling
namespace: biological_process
def: "Cell-cell signaling to, from or within a synapse." [GOC:dos]
subset: goslim_drosophila
subset: goslim_synapse
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: occurs_in GO:0045202 ! synapse
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa

[Term]
id: GO:0099537
name: trans-synaptic signaling
namespace: biological_process
def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling

[Term]
id: GO:0099538
name: synaptic signaling via neuropeptide
namespace: biological_process
def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099536 ! synaptic signaling
intersection_of: GO:0099536 ! synaptic signaling
intersection_of: process_has_causal_agent CHEBI:16670 ! peptide
relationship: process_has_causal_agent CHEBI:16670 ! peptide

[Term]
id: GO:0099540
name: trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
is_a: GO:0099538 ! synaptic signaling via neuropeptide
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: process_has_causal_agent CHEBI:16670 ! peptide

[Term]
id: GO:0099541
name: trans-synaptic signaling by lipid
namespace: biological_process
def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos]
subset: goslim_synapse
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: process_has_causal_agent CHEBI:18059 ! lipid
relationship: process_has_causal_agent CHEBI:18059 ! lipid

[Term]
id: GO:0099546
name: protein catabolic process, modulating synaptic transmission
namespace: biological_process
def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0007268 ! chemical synaptic transmission
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099547
name: regulation of translation at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0006412 ! translation
intersection_of: regulates GO:0007268 ! chemical synaptic transmission
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa

[Term]
id: GO:0099550
name: trans-synaptic signaling, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0099537 ! trans-synaptic signaling
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099551
name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: process_has_causal_agent CHEBI:16670 ! peptide
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099552
name: trans-synaptic signaling by lipid, modulating synaptic transmission
namespace: biological_process
def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099541 ! trans-synaptic signaling by lipid
is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission
intersection_of: GO:0099537 ! trans-synaptic signaling
intersection_of: process_has_causal_agent CHEBI:18059 ! lipid
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099568
name: cytoplasmic region
namespace: cellular_component
def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos]
subset: gocheck_do_not_annotate
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0099569
name: presynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: part_of GO:0098793 ! presynapse
relationship: part_of GO:0098793 ! presynapse

[Term]
id: GO:0099571
name: postsynaptic cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835]
subset: goslim_synapse
is_a: GO:0005856 ! cytoskeleton
intersection_of: GO:0005856 ! cytoskeleton
intersection_of: part_of GO:0098794 ! postsynapse
relationship: part_of GO:0098794 ! postsynapse

[Term]
id: GO:0099574
name: regulation of protein catabolic process at synapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0050804 ! modulation of chemical synaptic transmission
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0007268 ! chemical synaptic transmission
intersection_of: regulates GO:0009056 ! catabolic process
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa

[Term]
id: GO:0099575
name: regulation of protein catabolic process at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099576
name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
intersection_of: GO:0042176 ! regulation of protein catabolic process
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099577
name: regulation of translation at presynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140244 ! regulation of translation at presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0006412 ! translation
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099578
name: regulation of translation at postsynapse, modulating synaptic transmission
namespace: biological_process
def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission
is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission
is_a: GO:0140245 ! regulation of translation at postsynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0006412 ! translation
intersection_of: regulates GO:0007268 ! chemical synaptic transmission

[Term]
id: GO:0099632
name: protein transport within plasma membrane
namespace: biological_process
def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos]
is_a: GO:0032594 ! protein transport within lipid bilayer
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: occurs_in GO:0005886 ! plasma membrane
relationship: occurs_in GO:0005886 ! plasma membrane

[Term]
id: GO:0099640
name: axo-dendritic protein transport
namespace: biological_process
def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194]
subset: goslim_synapse
synonym: "axonal protein transport" NARROW []
is_a: GO:0008088 ! axo-dendritic transport
is_a: GO:0098840 ! protein transport along microtubule
intersection_of: GO:0046907 ! intracellular transport
intersection_of: has_primary_input PR:000000001 ! protein
intersection_of: occurs_in GO:0043005 ! neuron projection
intersection_of: results_in_transport_along GO:0005874 ! microtubule

[Term]
id: GO:0099643
name: signal release from synapse
namespace: biological_process
def: "Any signal release from a synapse." [GOC:dos]
subset: goslim_synapse
is_a: GO:0023061 ! signal release
intersection_of: GO:0023061 ! signal release
intersection_of: occurs_in GO:0045202 ! synapse
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: part_of GO:0099536 ! synaptic signaling

[Term]
id: GO:0099738
name: cell cortex region
namespace: cellular_component
def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]
subset: gocheck_do_not_annotate
synonym: "perimembrane region" EXACT []
is_a: GO:0005938 ! cell cortex
is_a: GO:0099568 ! cytoplasmic region
intersection_of: GO:0005938 ! cell cortex
intersection_of: part_of GO:0005938 ! cell cortex
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0100001
name: regulation of skeletal muscle contraction by action potential
namespace: biological_process
def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol]
is_a: BFO:0000015 ! process
is_a: GO:0001508 ! action potential
intersection_of: GO:0001508 ! action potential
intersection_of: regulates GO:0003009 ! skeletal muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction
created_by: cjm
creation_date: 2015-04-02T04:13:19Z

[Term]
id: GO:0101023
name: vascular endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774]
is_a: GO:0001935 ! endothelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000071 ! blood vessel endothelial cell
relationship: acts_on_population_of CL:0000071 ! blood vessel endothelial cell

[Term]
id: GO:0101024
name: mitotic nuclear membrane organization
namespace: biological_process
def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872]
comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown.
synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT []
is_a: GO:0071763 ! nuclear membrane organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0071763 ! nuclear membrane organization
intersection_of: part_of GO:0140014 ! mitotic nuclear division
relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: part_of GO:0140014 ! mitotic nuclear division
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19949" xsd:anyURI

[Term]
id: GO:0101025
name: nuclear membrane biogenesis
namespace: biological_process
def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw]
is_a: GO:0044091 ! membrane biogenesis
intersection_of: GO:0044085 ! cellular component biogenesis
intersection_of: has_primary_output GO:0031965 ! nuclear membrane
relationship: has_primary_output GO:0031965 ! nuclear membrane
relationship: part_of GO:0071763 ! nuclear membrane organization

[Term]
id: GO:0106027
name: neuron projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0043005 ! neuron projection
relationship: results_in_organization_of GO:0043005 ! neuron projection
created_by: hjd
creation_date: 2017-06-23T18:30:18Z

[Term]
id: GO:0106214
name: regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:1903358 ! regulation of Golgi organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: regulates GO:0048280 ! vesicle fusion with Golgi apparatus
created_by: hjd
creation_date: 2019-06-27T15:12:22Z

[Term]
id: GO:0106215
name: negative regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus
created_by: hjd
creation_date: 2019-06-27T15:17:17Z

[Term]
id: GO:0106216
name: positive regulation of vesicle fusion with Golgi apparatus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667]
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus
relationship: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus
created_by: hjd
creation_date: 2019-06-27T15:20:59Z

[Term]
id: GO:0110011
name: regulation of basement membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358]
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071711 ! basement membrane organization
relationship: regulates GO:0071711 ! basement membrane organization
created_by: kmv

[Term]
id: GO:0110020
name: regulation of actomyosin structure organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031032 ! actomyosin structure organization
relationship: regulates GO:0031032 ! actomyosin structure organization
created_by: kmv
creation_date: 2017-06-20T19:28:58Z

[Term]
id: GO:0110021
name: cardiac muscle myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0051450 ! myoblast proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000513 ! cardiac muscle myoblast
relationship: acts_on_population_of CL:0000513 ! cardiac muscle myoblast
created_by: kmv
creation_date: 2017-06-29T14:35:24Z

[Term]
id: GO:0110022
name: regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0110021 ! cardiac muscle myoblast proliferation
relationship: regulates GO:0110021 ! cardiac muscle myoblast proliferation
created_by: kmv
creation_date: 2017-06-29T15:11:47Z

[Term]
id: GO:0110023
name: negative regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000818 ! negative regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation
relationship: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation
created_by: kmv
creation_date: 2017-06-29T15:18:30Z

[Term]
id: GO:0110024
name: positive regulation of cardiac muscle myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644]
is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation
is_a: GO:2000288 ! positive regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation
relationship: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation
created_by: kmv
creation_date: 2017-06-29T15:24:16Z

[Term]
id: GO:0110053
name: regulation of actin filament organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007015 ! actin filament organization
relationship: regulates GO:0007015 ! actin filament organization
created_by: kmv
creation_date: 2017-09-20T19:52:57Z

[Term]
id: GO:0110057
name: regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060837 ! blood vessel endothelial cell differentiation
relationship: regulates GO:0060837 ! blood vessel endothelial cell differentiation
created_by: kmv
creation_date: 2017-10-23T14:32:09Z

[Term]
id: GO:0110058
name: positive regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045603 ! positive regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation
relationship: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation
created_by: kmv
creation_date: 2017-10-23T14:38:19Z

[Term]
id: GO:0110059
name: negative regulation of blood vessel endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816]
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation
relationship: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation
created_by: kmv
creation_date: 2017-10-23T14:47:29Z

[Term]
id: GO:0110077
name: vesicle-mediated intercellular transport
namespace: biological_process
def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916]
is_a: GO:0010496 ! intercellular transport
is_a: GO:0016192 ! vesicle-mediated transport
intersection_of: GO:0010496 ! intercellular transport
intersection_of: process_has_causal_agent GO:1903561 ! extracellular vesicle
relationship: process_has_causal_agent GO:1903561 ! extracellular vesicle
created_by: kmv
creation_date: 2018-01-29T14:46:52Z

[Term]
id: GO:0110079
name: regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060674 ! placenta blood vessel development
relationship: regulates GO:0060674 ! placenta blood vessel development
created_by: kmv
creation_date: 2018-02-01T14:49:12Z

[Term]
id: GO:0110080
name: positive regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0110079 ! regulation of placenta blood vessel development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060674 ! placenta blood vessel development
relationship: positively_regulates GO:0060674 ! placenta blood vessel development
created_by: kmv
creation_date: 2018-02-01T14:55:30Z

[Term]
id: GO:0110081
name: negative regulation of placenta blood vessel development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0110079 ! regulation of placenta blood vessel development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060674 ! placenta blood vessel development
relationship: negatively_regulates GO:0060674 ! placenta blood vessel development
created_by: kmv
creation_date: 2018-02-01T15:01:11Z

[Term]
id: GO:0110110
name: positive regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009887 ! animal organ morphogenesis
relationship: positively_regulates GO:0009887 ! animal organ morphogenesis
created_by: kmv
creation_date: 2018-07-05T14:10:14Z

[Term]
id: GO:0110111
name: negative regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009887 ! animal organ morphogenesis
relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis
created_by: kmv
creation_date: 2018-07-05T14:25:21Z

[Term]
id: GO:0110112
name: regulation of lipid transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_do_not_annotate
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032409 ! regulation of transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0005319 ! lipid transporter activity
relationship: regulates GO:0005319 ! lipid transporter activity
created_by: kmv
creation_date: 2018-07-06T18:53:55Z

[Term]
id: GO:0110113
name: positive regulation of lipid transporter activity
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_do_not_annotate
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0110112 ! regulation of lipid transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0005319 ! lipid transporter activity
relationship: positively_regulates GO:0005319 ! lipid transporter activity
created_by: kmv
creation_date: 2018-07-06T19:14:13Z

[Term]
id: GO:0110114
name: negative regulation of lipid transporter activity
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390]
subset: gocheck_do_not_annotate
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0110112 ! regulation of lipid transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0005319 ! lipid transporter activity
relationship: negatively_regulates GO:0005319 ! lipid transporter activity
created_by: kmv
creation_date: 2018-07-06T19:21:44Z

[Term]
id: GO:0110116
name: regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001751 ! compound eye photoreceptor cell differentiation
relationship: regulates GO:0001751 ! compound eye photoreceptor cell differentiation
created_by: kmv
creation_date: 2018-07-16T18:08:49Z

[Term]
id: GO:0110117
name: positive regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation
relationship: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation
created_by: kmv
creation_date: 2018-07-16T18:13:28Z

[Term]
id: GO:0110118
name: negative regulation of compound eye photoreceptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567]
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation
relationship: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation
created_by: kmv
creation_date: 2018-07-16T18:15:52Z

[Term]
id: GO:0110122
name: myotube cell migration
namespace: biological_process
def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742]
is_a: GO:0014812 ! muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0002372 ! myotube
relationship: results_in_movement_of CL:0002372 ! myotube
created_by: kmv
creation_date: 2018-08-22T20:58:09Z

[Term]
id: GO:0110123
name: regulation of myotube cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0110122 ! myotube cell migration
relationship: regulates GO:0110122 ! myotube cell migration
created_by: kmv
creation_date: 2018-08-22T21:06:53Z

[Term]
id: GO:0110124
name: positive regulation of myotube cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0110122 ! myotube cell migration
relationship: positively_regulates GO:0110122 ! myotube cell migration
created_by: kmv
creation_date: 2018-08-22T21:09:38Z

[Term]
id: GO:0110125
name: negative regulation of myotube cell migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0110123 ! regulation of myotube cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0110122 ! myotube cell migration
relationship: negatively_regulates GO:0110122 ! myotube cell migration
created_by: kmv
creation_date: 2018-08-22T21:12:47Z

[Term]
id: GO:0110165
name: cellular anatomical entity
namespace: cellular_component
def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]
subset: gocheck_do_not_annotate
subset: goslim_pir
is_a: CARO:0000000 ! anatomical entity
is_a: GO:0005575 ! cellular_component
is_a: UBERON:0000061 ! anatomical structure
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/24200" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI
created_by: kmv
creation_date: 2019-08-12T18:01:37Z

[Term]
id: GO:0120025
name: plasma membrane bounded cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
is_a: GO:0042995 ! cell projection
intersection_of: GO:0042995 ! cell projection
intersection_of: has_part GO:0098590 ! plasma membrane region
relationship: has_part GO:0098590 ! plasma membrane region
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13193" xsd:anyURI
created_by: krc
creation_date: 2017-03-21T17:26:07Z

[Term]
id: GO:0120031
name: plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]
synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0120036 ! plasma membrane bounded cell projection organization
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0120025 ! plasma membrane bounded cell projection
relationship: results_in_assembly_of GO:0120025 ! plasma membrane bounded cell projection
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-24T23:56:08Z

[Term]
id: GO:0120032
name: regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0060491 ! regulation of cell projection assembly
is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-26T04:27:04Z

[Term]
id: GO:0120033
name: negative regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-26T04:34:31Z

[Term]
id: GO:0120034
name: positive regulation of plasma membrane bounded cell projection assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly
relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-26T04:34:45Z

[Term]
id: GO:0120035
name: regulation of plasma membrane bounded cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]
is_a: GO:0031344 ! regulation of cell projection organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0120036 ! plasma membrane bounded cell projection organization
relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-26T16:02:06Z

[Term]
id: GO:0120036
name: plasma membrane bounded cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]
is_a: GO:0030030 ! cell projection organization
intersection_of: GO:0016043 ! cellular component organization
intersection_of: results_in_organization_of GO:0120025 ! plasma membrane bounded cell projection
relationship: results_in_organization_of GO:0120025 ! plasma membrane bounded cell projection
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-26T16:07:02Z

[Term]
id: GO:0120039
name: plasma membrane bounded cell projection morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc]
is_a: GO:0048858 ! cell projection morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of GO:0120025 ! plasma membrane bounded cell projection
relationship: results_in_morphogenesis_of GO:0120025 ! plasma membrane bounded cell projection
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/13298" xsd:anyURI
created_by: krc
creation_date: 2017-04-28T23:39:37Z

[Term]
id: GO:0120111
name: neuron projection cytoplasm
namespace: cellular_component
def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]
is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of GO:0043005 ! neuron projection
relationship: part_of GO:0043005 ! neuron projection
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14472" xsd:anyURI
created_by: krc
creation_date: 2017-11-01T18:58:12Z

[Term]
id: GO:0120158
name: positive regulation of collagen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb]
synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030574 ! collagen catabolic process
relationship: positively_regulates GO:0030574 ! collagen catabolic process
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15720" xsd:anyURI
created_by: krc
creation_date: 2018-05-11T16:31:42Z

[Term]
id: GO:0120178
name: steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln]
is_a: GO:0006694 ! steroid biosynthetic process
intersection_of: GO:0006694 ! steroid biosynthetic process
intersection_of: has_primary_output CHEBI:26764 ! steroid hormone
relationship: has_primary_output CHEBI:26764 ! steroid hormone
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16000" xsd:anyURI
created_by: krc
creation_date: 2019-05-20T22:34:00Z

[Term]
id: GO:0120186
name: negative regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071168 ! protein localization to chromatin
relationship: negatively_regulates GO:0071168 ! protein localization to chromatin
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16012" xsd:anyURI
created_by: krc
creation_date: 2018-07-14T00:19:32Z

[Term]
id: GO:0120187
name: positive regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]
synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905634 ! regulation of protein localization to chromatin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071168 ! protein localization to chromatin
relationship: positively_regulates GO:0071168 ! protein localization to chromatin
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16012" xsd:anyURI
created_by: krc
creation_date: 2018-07-14T00:21:28Z

[Term]
id: GO:0120188
name: regulation of bile acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032782 ! bile acid secretion
relationship: regulates GO:0032782 ! bile acid secretion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI
created_by: krc
creation_date: 2018-07-16T22:28:58Z

[Term]
id: GO:0120189
name: positive regulation of bile acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032782 ! bile acid secretion
relationship: positively_regulates GO:0032782 ! bile acid secretion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI
created_by: krc
creation_date: 2018-07-16T22:36:17Z

[Term]
id: GO:0120190
name: negative regulation of bile acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0120188 ! regulation of bile acid secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032782 ! bile acid secretion
relationship: negatively_regulates GO:0032782 ! bile acid secretion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/16040" xsd:anyURI
created_by: krc
creation_date: 2018-07-16T22:38:34Z

[Term]
id: GO:0120222
name: regulation of blastocyst development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001824 ! blastocyst development
relationship: regulates GO:0001824 ! blastocyst development
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18871" xsd:anyURI
created_by: krc
creation_date: 2020-02-17T19:59:20Z

[Term]
id: GO:0120229
name: protein localization to motile cilium
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780]
synonym: "protein localization to nonmotile primary cilium" RELATED []
is_a: GO:0061512 ! protein localization to cilium
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0031514 ! motile cilium
relationship: has_target_end_location GO:0031514 ! motile cilium
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19588" xsd:anyURI
created_by: krc
creation_date: 2020-06-05T23:43:04Z

[Term]
id: GO:0120305
name: regulation of pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0043473 ! pigmentation
relationship: regulates GO:0043473 ! pigmentation
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20524" xsd:anyURI
created_by: krc
creation_date: 2021-02-09T19:37:35Z

[Term]
id: GO:0120316
name: sperm flagellum assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." [GOC:krc, PMID:32791035]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:0044458 ! motile cilium assembly
intersection_of: GO:0044458 ! motile cilium assembly
intersection_of: occurs_in CL:0000019 ! sperm
relationship: occurs_in CL:0000019 ! sperm
relationship: part_of GO:0007286 ! spermatid development
relationship: part_of GO:0030317 ! flagellated sperm motility
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21361" xsd:anyURI
created_by: krc
creation_date: 2021-04-29T01:27:27Z

[Term]
id: GO:0120331
name: endothelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endothelial tube." [GOC:sl, PMID:23239824]
is_a: GO:0072175 ! epithelial tube formation
intersection_of: GO:0035148 ! tube formation
intersection_of: results_in_formation_of_anatomical_entity UBERON:0003915 ! endothelial tube
relationship: part_of GO:0061154 ! endothelial tube morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0003915 ! endothelial tube
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22302" xsd:anyURI
created_by: krc
creation_date: 2022-05-25T16:17:59Z

[Term]
id: GO:0140013
name: meiotic nuclear division
namespace: biological_process
def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324]
subset: goslim_generic
synonym: "meiosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0051321 ! meiotic cell cycle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI
created_by: pg
creation_date: 2017-03-23T09:40:00Z

[Term]
id: GO:0140014
name: mitotic nuclear division
namespace: biological_process
def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684]
subset: goslim_chembl
subset: goslim_generic
synonym: "mitosis" EXACT []
is_a: GO:0000280 ! nuclear division
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000280 ! nuclear division
intersection_of: part_of GO:0000278 ! mitotic cell cycle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19910" xsd:anyURI
created_by: pg
creation_date: 2017-03-23T14:44:23Z

[Term]
id: GO:0140029
name: exocytic process
namespace: biological_process
def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis]
subset: gocheck_do_not_annotate
is_a: GO:0009987 ! cellular process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0006887 ! exocytosis
relationship: part_of GO:0006887 ! exocytosis
created_by: pg
creation_date: 2017-05-15T13:20:45Z

[Term]
id: GO:0140056
name: organelle localization by membrane tethering
namespace: biological_process
def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684]
subset: goslim_pombe
is_a: GO:0022406 ! membrane docking
is_a: GO:0051640 ! organelle localization
created_by: pg
creation_date: 2017-06-27T09:58:51Z

[Term]
id: GO:0140096
name: catalytic activity, acting on a protein
namespace: molecular_function
def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0003824 ! catalytic activity
intersection_of: GO:0003824 ! catalytic activity
intersection_of: has_primary_input PR:000000001 ! protein
relationship: has_primary_input PR:000000001 ! protein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI
created_by: pg
creation_date: 2017-09-14T10:32:59Z

[Term]
id: GO:0140097
name: catalytic activity, acting on DNA
namespace: molecular_function
def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid
intersection_of: GO:0003824 ! catalytic activity
intersection_of: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
relationship: has_primary_input CHEBI:16991 ! deoxyribonucleic acid
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI
created_by: pg
creation_date: 2017-09-14T12:03:51Z

[Term]
id: GO:0140098
name: catalytic activity, acting on RNA
namespace: molecular_function
def: "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]
subset: goslim_generic
subset: goslim_prokaryote
is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid
intersection_of: GO:0003824 ! catalytic activity
intersection_of: has_primary_input CHEBI:33697 ! ribonucleic acid
relationship: has_primary_input CHEBI:33697 ! ribonucleic acid
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI
created_by: pg
creation_date: 2017-09-14T12:05:21Z

[Term]
id: GO:0140103
name: catalytic activity, acting on a glycoprotein
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]
is_a: GO:0003824 ! catalytic activity
intersection_of: GO:0003824 ! catalytic activity
intersection_of: has_primary_input CHEBI:17089 ! glycoprotein
relationship: has_primary_input CHEBI:17089 ! glycoprotein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14225" xsd:anyURI
created_by: pg
creation_date: 2017-09-15T19:27:54Z

[Term]
id: GO:0140112
name: extracellular vesicle biogenesis
namespace: biological_process
def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435]
synonym: "extracellular vesicle assembly" EXACT []
is_a: GO:0044085 ! cellular component biogenesis
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/14256" xsd:anyURI
created_by: pg
creation_date: 2017-10-23T11:53:42Z

[Term]
id: GO:0140236
name: translation at presynapse
namespace: biological_process
def: "Translation that occurs at the presynapse." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/216" xsd:anyURI
created_by: pg
creation_date: 2018-07-13T13:00:33Z

[Term]
id: GO:0140237
name: translation at presynapse, modulating chemical synaptic transmission
namespace: biological_process
def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140236 ! translation at presynapse
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0007268 ! chemical synaptic transmission
relationship: regulates GO:0007268 ! chemical synaptic transmission
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/216" xsd:anyURI
created_by: pg
creation_date: 2018-07-13T13:07:23Z

[Term]
id: GO:0140238
name: presynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse
intersection_of: GO:0006897 ! endocytosis
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/230" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T07:33:55Z

[Term]
id: GO:0140239
name: postsynaptic endocytosis
namespace: biological_process
def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006897 ! endocytosis
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0099003 ! vesicle-mediated transport in synapse
intersection_of: GO:0006897 ! endocytosis
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/230" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T07:38:27Z

[Term]
id: GO:0140241
name: translation at synapse
namespace: biological_process
def: "Translation that occurs at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006412 ! translation
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0045202 ! synapse
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T09:23:12Z

[Term]
id: GO:0140242
name: translation at postsynapse
namespace: biological_process
def: "Translation that occurs at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140241 ! translation at synapse
intersection_of: GO:0006412 ! translation
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T09:26:27Z

[Term]
id: GO:0140243
name: regulation of translation at synapse
namespace: biological_process
def: "Any process that regulates translation occurring at the synapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0006417 ! regulation of translation
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0006412 ! translation
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T09:38:26Z

[Term]
id: GO:0140244
name: regulation of translation at presynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0006412 ! translation
relationship: occurs_in GO:0098793 ! presynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T09:38:33Z

[Term]
id: GO:0140245
name: regulation of translation at postsynapse
namespace: biological_process
def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140243 ! regulation of translation at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0006412 ! translation
relationship: occurs_in GO:0098794 ! postsynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T09:38:54Z

[Term]
id: GO:0140246
name: protein catabolic process at synapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0009057 ! macromolecule catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0045202 ! synapse
relationship: has_primary_input CHEBI:36080 ! protein
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/210" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:12:51Z

[Term]
id: GO:0140247
name: protein catabolic process at presynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0098793 ! presynapse
relationship: occurs_in GO:0098793 ! presynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:23:49Z

[Term]
id: GO:0140249
name: protein catabolic process at postsynapse
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140246 ! protein catabolic process at synapse
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0098794 ! postsynapse
relationship: occurs_in GO:0098794 ! postsynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:25:04Z

[Term]
id: GO:0140250
name: regulation protein catabolic process at synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0009894 ! regulation of catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0045202 ! synapse
intersection_of: regulates GO:0009056 ! catabolic process
relationship: has_primary_input CHEBI:36080 ! protein
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: occurs_in GO:0045202 ! synapse
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:34:56Z

[Term]
id: GO:0140251
name: regulation protein catabolic process at presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0098793 ! presynapse
intersection_of: regulates GO:0009056 ! catabolic process
relationship: occurs_in GO:0098793 ! presynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:35:39Z

[Term]
id: GO:0140252
name: regulation protein catabolic process at postsynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563]
comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua.
subset: goslim_synapse
is_a: GO:0140250 ! regulation protein catabolic process at synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: has_primary_input CHEBI:36080 ! protein
intersection_of: occurs_in GO:0098794 ! postsynapse
intersection_of: regulates GO:0009056 ! catabolic process
relationship: occurs_in GO:0098794 ! postsynapse
property_value: IAO:0000233 "https://github.com/geneontology/synapse/issues/204" xsd:anyURI
created_by: pg
creation_date: 2018-07-15T10:35:56Z

[Term]
id: GO:0140253
name: cell-cell fusion
namespace: biological_process
def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion]
synonym: "cell cell fusion" EXACT []
synonym: "cell fusion" BROAD []
is_a: GO:0009987 ! cellular process
relationship: has_part GO:0045026 ! plasma membrane fusion
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/15939" xsd:anyURI
created_by: pg
creation_date: 2018-08-13T18:38:18Z

[Term]
id: GO:0140318
name: protein transporter activity
namespace: molecular_function
def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]
comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation.
synonym: "protein carrier activity" RELATED []
synonym: "protein transport chaperone" RELATED []
xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network"
xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane"
is_a: GO:0005215 ! transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: has_primary_input PR:000000001 ! protein
relationship: has_primary_input PR:000000001 ! protein
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/17073" xsd:anyURI
created_by: pg
creation_date: 2019-04-01T10:41:38Z

[Term]
id: GO:0140352
name: export from cell
namespace: biological_process
def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg]
synonym: "efflux" BROAD []
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process
intersection_of: GO:0006810 ! transport
intersection_of: has_target_end_location GO:0005576 ! extracellular region
intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_end_location GO:0005576 ! extracellular region
relationship: has_target_start_location GO:0005622 ! intracellular anatomical structure
created_by: pg
creation_date: 2019-05-22T11:20:45Z

[Term]
id: GO:0140353
name: lipid export from cell
namespace: biological_process
def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg]
synonym: "lipid efflux" BROAD []
is_a: GO:0006869 ! lipid transport
is_a: GO:0140352 ! export from cell
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18059 ! lipid
intersection_of: has_target_end_location GO:0005576 ! extracellular region
intersection_of: has_target_start_location GO:0005622 ! intracellular anatomical structure
created_by: pg
creation_date: 2019-05-22T11:33:07Z

[Term]
id: GO:0140354
name: lipid import into cell
namespace: biological_process
def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg]
synonym: "lipid uptake" BROAD []
is_a: GO:0006869 ! lipid transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:18059 ! lipid
intersection_of: has_target_end_location GO:0005622 ! intracellular anatomical structure
intersection_of: has_target_start_location GO:0005576 ! extracellular region
relationship: has_target_end_location GO:0005622 ! intracellular anatomical structure
relationship: has_target_start_location GO:0005576 ! extracellular region
created_by: pg
creation_date: 2019-05-22T11:38:15Z

[Term]
id: GO:0140513
name: nuclear protein-containing complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]
subset: gocheck_do_not_annotate
synonym: "nuclear complex" EXACT []
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005634 ! nucleus
created_by: pg
creation_date: 2020-09-09T05:12:38Z

[Term]
id: GO:0140572
name: vacuole fission
namespace: biological_process
def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199]
is_a: GO:0048285 ! organelle fission
intersection_of: GO:0048285 ! organelle fission
intersection_of: results_in_fission_of GO:0005773 ! vacuole
relationship: results_in_fission_of GO:0005773 ! vacuole
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/20639" xsd:anyURI
created_by: pg
creation_date: 2021-01-04T10:17:58Z

[Term]
id: GO:0140640
name: catalytic activity, acting on a nucleic acid
namespace: molecular_function
def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg]
is_a: GO:0003824 ! catalytic activity
intersection_of: GO:0003824 ! catalytic activity
intersection_of: has_primary_input CHEBI:33696 ! nucleic acid
relationship: has_primary_input CHEBI:33696 ! nucleic acid
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21402" xsd:anyURI
created_by: pg
creation_date: 2021-05-11T06:31:07Z

[Term]
id: GO:0140694
name: non-membrane-bounded organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]
synonym: "non-membrane-bounded organelle formation" EXACT []
synonym: "non-membrane-enclosed organelle assembly" EXACT []
synonym: "non-membrane-enclosed organelle formation" EXACT []
is_a: GO:0070925 ! organelle assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0043228 ! non-membrane-bounded organelle
relationship: results_in_assembly_of GO:0043228 ! non-membrane-bounded organelle
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/21939" xsd:anyURI
created_by: pg
creation_date: 2021-08-09T15:30:06Z

[Term]
id: GO:0140734
name: ammonium excretion
namespace: biological_process
def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900]
synonym: "ammonia excretion" RELATED []
is_a: GO:0007588 ! excretion
intersection_of: GO:0007588 ! excretion
intersection_of: has_primary_input CHEBI:28938 ! ammonium
relationship: has_primary_input CHEBI:28938 ! ammonium
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22368" xsd:anyURI
created_by: pg
creation_date: 2021-11-24T17:55:51Z

[Term]
id: GO:0140961
name: cellular detoxification of metal ion
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion." [PMID:26729300, PMID:33046888, PMID:34442707]
synonym: "cellular detoxification of metal cation" EXACT []
is_a: GO:0061687 ! detoxification of inorganic compound
is_a: GO:1990748 ! cellular detoxification
intersection_of: GO:1990748 ! cellular detoxification
intersection_of: has_primary_input CHEBI:25213 ! metal cation
relationship: has_primary_input CHEBI:25213 ! metal cation
created_by: pg
creation_date: 2022-12-07T15:35:18Z

[Term]
id: GO:0150052
name: regulation of postsynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854]
subset: goslim_synapse
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099175 ! regulation of postsynapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099068 ! postsynapse assembly
relationship: regulates GO:0099068 ! postsynapse assembly
created_by: bc
creation_date: 2018-05-08T16:38:55Z

[Term]
id: GO:0150063
name: visual system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727]
synonym: "optic pathway development" RELATED []
synonym: "visual pathway development" RELATED []
is_a: GO:0048880 ! sensory system development
created_by: bc
creation_date: 2018-07-23T10:31:58Z

[Term]
id: GO:0150076
name: neuroinflammatory response
namespace: biological_process
def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
synonym: "nerve tissue inflammatory response" EXACT []
synonym: "nervous tissue inflammatory response" EXACT []
synonym: "neural tissue inflammatory response" EXACT []
is_a: GO:0006954 ! inflammatory response
created_by: bc
creation_date: 2018-07-26T12:25:34Z

[Term]
id: GO:0150077
name: regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0150076 ! neuroinflammatory response
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: regulates GO:0150076 ! neuroinflammatory response
created_by: bc
creation_date: 2018-07-26T12:32:18Z

[Term]
id: GO:0150078
name: positive regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc]
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0150076 ! neuroinflammatory response
relationship: positively_regulates GO:0150076 ! neuroinflammatory response
created_by: bc
creation_date: 2018-07-26T12:35:50Z

[Term]
id: GO:0150079
name: negative regulation of neuroinflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423]
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0150077 ! regulation of neuroinflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0150076 ! neuroinflammatory response
relationship: negatively_regulates GO:0150076 ! neuroinflammatory response
created_by: bc
creation_date: 2018-07-26T12:38:08Z

[Term]
id: GO:0150098
name: glial cell-neuron signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440]
synonym: "glia-neuron signaling" EXACT []
synonym: "glia-neuron signalling" EXACT []
synonym: "glia-neurone signaling" EXACT []
synonym: "glia-neurone signalling" EXACT []
synonym: "glial cell- neuron signalling" EXACT []
synonym: "glial cell-neurone signalling" EXACT []
synonym: "glial cell-neurone singaling" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000540 ! neuron
intersection_of: has_start_location CL:0000125 ! glial cell
relationship: has_end_location CL:0000540 ! neuron
relationship: has_start_location CL:0000125 ! glial cell
created_by: bc
creation_date: 2018-12-17T12:28:09Z

[Term]
id: GO:0150099
name: neuron-glial cell signaling
namespace: biological_process
def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368]
synonym: "neuron-glia signaling" EXACT []
synonym: "neuron-glia signalling" EXACT []
synonym: "neuron-glial cell signalling" EXACT []
synonym: "neurone-glia signaling" EXACT []
synonym: "neurone-glia signalling" EXACT []
synonym: "neurone-glial cell signaling" EXACT []
synonym: "neurone-glial cell signalling" EXACT []
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: has_end_location CL:0000125 ! glial cell
intersection_of: has_start_location CL:0000540 ! neuron
relationship: has_end_location CL:0000125 ! glial cell
relationship: has_start_location CL:0000540 ! neuron
created_by: bc
creation_date: 2018-12-17T12:30:12Z

[Term]
id: GO:0150105
name: protein localization to cell-cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:1902414 ! protein localization to cell junction
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005911 ! cell-cell junction
relationship: has_target_end_location GO:0005911 ! cell-cell junction
created_by: bc
creation_date: 2019-06-11T11:00:18Z

[Term]
id: GO:0150106
name: regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0150105 ! protein localization to cell-cell junction
relationship: regulates GO:0150105 ! protein localization to cell-cell junction
created_by: bc
creation_date: 2019-06-11T11:17:15Z

[Term]
id: GO:0150107
name: positive regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0150105 ! protein localization to cell-cell junction
relationship: positively_regulates GO:0150105 ! protein localization to cell-cell junction
created_by: bc
creation_date: 2019-06-11T11:23:58Z

[Term]
id: GO:0150111
name: regulation of transepithelial transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915]
is_a: GO:0051049 ! regulation of transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070633 ! transepithelial transport
relationship: regulates GO:0070633 ! transepithelial transport
created_by: bc
creation_date: 2019-09-15T07:16:49Z

[Term]
id: GO:0150119
name: negative regulation of protein localization to cell-cell junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc]
synonym: "negative regulation of protein localisation to cell-cell junction" EXACT []
is_a: GO:0150106 ! regulation of protein localization to cell-cell junction
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0150105 ! protein localization to cell-cell junction
relationship: negatively_regulates GO:0150105 ! protein localization to cell-cell junction
created_by: bc
creation_date: 2019-11-21T13:53:34Z

[Term]
id: GO:0150146
name: cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0034330 ! cell junction organization
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0030054 ! cell junction
relationship: results_in_disassembly_of GO:0030054 ! cell junction
created_by: bc
creation_date: 2019-12-08T11:12:13Z

[Term]
id: GO:0150147
name: cell-cell junction disassembly
namespace: biological_process
def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267]
is_a: GO:0045216 ! cell-cell junction organization
is_a: GO:0150146 ! cell junction disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005911 ! cell-cell junction
relationship: results_in_disassembly_of GO:0005911 ! cell-cell junction
created_by: bc
creation_date: 2019-12-08T11:16:14Z

[Term]
id: GO:0160038
name: somatic sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain." [PMID:25832476, PMID:31399790]
synonym: "somatosensory system development" EXACT []
is_a: GO:0048880 ! sensory system development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0003942 ! somatosensory system
relationship: results_in_development_of UBERON:0003942 ! somatosensory system
created_by: rynl
creation_date: 2022-07-07T16:49:26Z

[Term]
id: GO:0160043
name: catecholamine secretion, neurotransmission
namespace: biological_process
def: "The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter." [PMID:10191060]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0050432 ! catecholamine secretion
intersection_of: GO:0007269 ! neurotransmitter secretion
intersection_of: has_primary_input CHEBI:33567 ! catecholamine
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/23804" xsd:anyURI
created_by: rynl
creation_date: 2022-08-17T00:36:44Z

[Term]
id: GO:0160093
name: chordate pharynx development
namespace: biological_process
def: "The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure." [PMID:23020903]
is_a: GO:0060465 ! pharynx development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001042 ! chordate pharynx
relationship: results_in_development_of UBERON:0001042 ! chordate pharynx
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/18285" xsd:anyURI
created_by: rynl
creation_date: 2023-08-29T21:05:28Z

[Term]
id: GO:1900015
name: regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001817 ! regulation of cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:27Z

[Term]
id: GO:1900016
name: negative regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:31Z

[Term]
id: GO:1900017
name: positive regulation of cytokine production involved in inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie]
synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie]
synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response
relationship: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response
created_by: rph
creation_date: 2012-01-11T09:34:35Z

[Term]
id: GO:1900073
name: regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
is_a: GO:0050804 ! modulation of chemical synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:10Z

[Term]
id: GO:1900074
name: negative regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:18Z

[Term]
id: GO:1900075
name: positive regulation of neuromuscular synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie]
synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie]
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007274 ! neuromuscular synaptic transmission
relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmission
created_by: kmv
creation_date: 2012-01-26T10:14:22Z

[Term]
id: GO:1900115
name: extracellular regulation of signal transduction
namespace: biological_process
def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0009966 ! regulation of signal transduction
intersection_of: occurs_in GO:0005576 ! extracellular region
relationship: occurs_in GO:0005576 ! extracellular region
created_by: bf
creation_date: 2012-02-22T10:21:48Z

[Term]
id: GO:1900116
name: extracellular negative regulation of signal transduction
namespace: biological_process
def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie]
synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie]
synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf]
synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie]
synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie]
synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1900115 ! extracellular regulation of signal transduction
intersection_of: GO:0009968 ! negative regulation of signal transduction
intersection_of: occurs_in GO:0005576 ! extracellular region
created_by: bf
creation_date: 2012-02-22T10:27:56Z

[Term]
id: GO:1900117
name: regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097194 ! execution phase of apoptosis
relationship: regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:20Z

[Term]
id: GO:1900118
name: negative regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097194 ! execution phase of apoptosis
relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:24Z

[Term]
id: GO:1900119
name: positive regulation of execution phase of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]
synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1900117 ! regulation of execution phase of apoptosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097194 ! execution phase of apoptosis
relationship: positively_regulates GO:0097194 ! execution phase of apoptosis
created_by: pr
creation_date: 2012-02-22T11:26:27Z

[Term]
id: GO:1900125
name: regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:21Z

[Term]
id: GO:1900126
name: negative regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:29Z

[Term]
id: GO:1900127
name: positive regulation of hyaluronan biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf]
synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie]
synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030213 ! hyaluronan biosynthetic process
relationship: positively_regulates GO:0030213 ! hyaluronan biosynthetic process
created_by: yaf
creation_date: 2012-02-23T01:09:33Z

[Term]
id: GO:1900150
name: regulation of defense response to fungus
namespace: biological_process
alt_id: GO:2000072
def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006]
synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol]
synonym: "regulation of defense response to fungus, incompatible interaction" NARROW []
synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol]
synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol]
synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050832 ! defense response to fungus
relationship: regulates GO:0050832 ! defense response to fungus
created_by: dhl
creation_date: 2012-03-06T10:00:16Z

[Term]
id: GO:1900180
name: regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034504 ! protein localization to nucleus
relationship: regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:44Z

[Term]
id: GO:1900181
name: negative regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034504 ! protein localization to nucleus
relationship: negatively_regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:48Z

[Term]
id: GO:1900182
name: positive regulation of protein localization to nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]
synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034504 ! protein localization to nucleus
relationship: positively_regulates GO:0034504 ! protein localization to nucleus
created_by: bf
creation_date: 2012-03-12T01:23:52Z

[Term]
id: GO:1900193
name: regulation of oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001556 ! oocyte maturation
relationship: regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:18Z

[Term]
id: GO:1900194
name: negative regulation of oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001556 ! oocyte maturation
relationship: negatively_regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:27Z

[Term]
id: GO:1900195
name: positive regulation of oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie]
synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:1900193 ! regulation of oocyte maturation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001556 ! oocyte maturation
relationship: positively_regulates GO:0001556 ! oocyte maturation
created_by: kmv
creation_date: 2012-03-19T09:41:35Z

[Term]
id: GO:1900200
name: mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:0097152 ! mesenchymal cell apoptotic process
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0001656 ! metanephros development
relationship: part_of GO:0001656 ! metanephros development
created_by: yaf
creation_date: 2012-03-21T11:58:05Z

[Term]
id: GO:1900204
name: apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0072205 ! metanephric collecting duct development
relationship: part_of GO:0072205 ! metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-21T01:21:32Z

[Term]
id: GO:1900205
name: apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1902742 ! apoptotic process involved in development
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0072234 ! metanephric nephron tubule development
relationship: part_of GO:0072234 ! metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-21T01:21:45Z

[Term]
id: GO:1900206
name: regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0039020 ! pronephric nephron tubule development
relationship: regulates GO:0039020 ! pronephric nephron tubule development
created_by: bf
creation_date: 2012-03-22T09:23:13Z

[Term]
id: GO:1900207
name: negative regulation of pronephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706]
synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1900206 ! regulation of pronephric nephron tubule development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0039020 ! pronephric nephron tubule development
relationship: negatively_regulates GO:0039020 ! pronephric nephron tubule development
created_by: bf
creation_date: 2012-03-22T09:23:23Z

[Term]
id: GO:1900211
name: regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:1904748 ! regulation of apoptotic process involved in development
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:52:50Z

[Term]
id: GO:1900212
name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:53:00Z

[Term]
id: GO:1900213
name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW []
synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie]
is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
relationship: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
created_by: yaf
creation_date: 2012-03-22T10:53:09Z

[Term]
id: GO:1900214
name: regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:21Z

[Term]
id: GO:1900215
name: negative regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:31Z

[Term]
id: GO:1900216
name: positive regulation of apoptotic process involved in metanephric collecting duct development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie]
is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
relationship: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development
created_by: yaf
creation_date: 2012-03-22T10:53:39Z

[Term]
id: GO:1900217
name: regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:53:51Z

[Term]
id: GO:1900218
name: negative regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:54:01Z

[Term]
id: GO:1900219
name: positive regulation of apoptotic process involved in metanephric nephron tubule development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325]
synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie]
is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
relationship: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development
created_by: yaf
creation_date: 2012-03-22T10:54:09Z

[Term]
id: GO:1900366
name: negative regulation of defense response to insect
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie]
synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "susceptibility to insect" RELATED []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002213 ! defense response to insect
relationship: negatively_regulates GO:0002213 ! defense response to insect
created_by: dhl
creation_date: 2012-04-12T04:44:00Z

[Term]
id: GO:1900367
name: positive regulation of defense response to insect
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183]
synonym: "activation of defense response to insect" NARROW [GOC:TermGenie]
synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie]
synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie]
synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie]
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:2000068 ! regulation of defense response to insect
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002213 ! defense response to insect
relationship: positively_regulates GO:0002213 ! defense response to insect
created_by: dhl
creation_date: 2012-04-12T04:44:10Z

[Term]
id: GO:1900376
name: regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:23Z

[Term]
id: GO:1900377
name: negative regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:32Z

[Term]
id: GO:1900378
name: positive regulation of secondary metabolite biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process
relationship: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process
created_by: di
creation_date: 2012-04-17T01:55:41Z

[Term]
id: GO:1900424
name: regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902477
def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "regulation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "regulation of defense response to bacterium, incompatible interaction" NARROW []
synonym: "regulation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "regulation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042742 ! defense response to bacterium
relationship: regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:12:43Z

[Term]
id: GO:1900425
name: negative regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902478
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie]
synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "negative regulation of defense response to bacterium, incompatible interaction" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042742 ! defense response to bacterium
relationship: negatively_regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:12:54Z

[Term]
id: GO:1900426
name: positive regulation of defense response to bacterium
namespace: biological_process
alt_id: GO:1902479
def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]
synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie]
synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie]
synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "positive regulation of defense response to bacterium, incompatible interaction" NARROW []
synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie]
synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie]
synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie]
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042742 ! defense response to bacterium
relationship: positively_regulates GO:0042742 ! defense response to bacterium
created_by: dhl
creation_date: 2012-04-24T10:13:13Z

[Term]
id: GO:1900619
name: acetate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie]
synonym: "acetate ester metabolism" EXACT [GOC:TermGenie]
synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622]
synonym: "acetyl ester metabolism" EXACT [CHEBI:47622]
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:47622 ! acetate ester
relationship: has_primary_input_or_output CHEBI:47622 ! acetate ester
created_by: bf
creation_date: 2012-05-16T12:29:51Z

[Term]
id: GO:1900620
name: acetate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596]
synonym: "acetate ester anabolism" EXACT [GOC:TermGenie]
synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie]
synonym: "acetate ester formation" EXACT [GOC:TermGenie]
synonym: "acetate ester synthesis" EXACT [GOC:TermGenie]
synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622]
synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622]
is_a: GO:1900619 ! acetate ester metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:47622 ! acetate ester
relationship: has_primary_output CHEBI:47622 ! acetate ester
created_by: bf
creation_date: 2012-05-16T12:30:12Z

[Term]
id: GO:1901071
name: glucosamine-containing compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound metabolism" EXACT [GOC:bf]
synonym: "glucosamines metabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006040 ! amino sugar metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:24271 ! glucosamines
relationship: has_primary_input_or_output CHEBI:24271 ! glucosamines
created_by: bf
creation_date: 2012-07-02T03:18:04Z

[Term]
id: GO:1901072
name: glucosamine-containing compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound breakdown" EXACT [GOC:bf]
synonym: "glucosamine-containing compound catabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound degradation" EXACT [GOC:bf]
synonym: "glucosamines breakdown" EXACT [GOC:TermGenie]
synonym: "glucosamines catabolic process" EXACT [CHEBI:24271]
synonym: "glucosamines catabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines degradation" EXACT [GOC:TermGenie]
is_a: GO:0046348 ! amino sugar catabolic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:24271 ! glucosamines
relationship: has_primary_input CHEBI:24271 ! glucosamines
created_by: bf
creation_date: 2012-07-02T03:18:25Z

[Term]
id: GO:1901073
name: glucosamine-containing compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]
synonym: "glucosamine-containing compound anabolism" EXACT [GOC:bf]
synonym: "glucosamine-containing compound biosynthesis" EXACT [GOC:bf]
synonym: "glucosamine-containing compound formation" EXACT [GOC:bf]
synonym: "glucosamine-containing compound synthesis" EXACT [GOC:bf]
synonym: "glucosamines anabolism" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthesis" EXACT [GOC:TermGenie]
synonym: "glucosamines biosynthetic process" EXACT [CHEBI:24271]
synonym: "glucosamines formation" EXACT [GOC:TermGenie]
synonym: "glucosamines synthesis" EXACT [GOC:TermGenie]
is_a: GO:0046349 ! amino sugar biosynthetic process
is_a: GO:1901071 ! glucosamine-containing compound metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:24271 ! glucosamines
relationship: has_primary_output CHEBI:24271 ! glucosamines
created_by: bf
creation_date: 2012-07-02T03:18:33Z

[Term]
id: GO:1901135
name: carbohydrate derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]
subset: goslim_agr
subset: goslim_generic
subset: goslim_mouse
subset: goslim_prokaryote
synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:63299 ! carbohydrate derivative
relationship: has_primary_input_or_output CHEBI:63299 ! carbohydrate derivative
created_by: bf
creation_date: 2012-07-12T04:05:09Z

[Term]
id: GO:1901136
name: carbohydrate derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative
relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative
created_by: bf
creation_date: 2012-07-12T04:05:31Z

[Term]
id: GO:1901137
name: carbohydrate derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]
synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie]
synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901135 ! carbohydrate derivative metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:63299 ! carbohydrate derivative
relationship: has_primary_output CHEBI:63299 ! carbohydrate derivative
created_by: bf
creation_date: 2012-07-12T04:05:39Z

[Term]
id: GO:1901142
name: insulin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie]
synonym: "insulin metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019538 ! protein metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output PR:000009054 ! insulin gene translation product
relationship: has_primary_input_or_output PR:000009054 ! insulin gene translation product
property_value: RO:0002161 NCBITaxon:33090
property_value: RO:0002161 NCBITaxon_Union:0000023
created_by: pm
creation_date: 2012-07-13T12:32:40Z

[Term]
id: GO:1901143
name: insulin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie]
synonym: "insulin breakdown" EXACT [GOC:TermGenie]
synonym: "insulin catabolism" EXACT [GOC:TermGenie]
synonym: "insulin degradation" EXACT [GOC:TermGenie]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:1901142 ! insulin metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input PR:000009054 ! insulin gene translation product
relationship: has_primary_input PR:000009054 ! insulin gene translation product
created_by: pm
creation_date: 2012-07-13T12:33:03Z

[Term]
id: GO:1901145
name: mesenchymal cell apoptotic process involved in nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
is_a: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T01:43:51Z

[Term]
id: GO:1901146
name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0061228 ! mesonephric nephron morphogenesis
relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T02:40:43Z

[Term]
id: GO:1901147
name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
namespace: biological_process
def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie]
is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development
is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis
intersection_of: GO:0097152 ! mesenchymal cell apoptotic process
intersection_of: part_of GO:0072273 ! metanephric nephron morphogenesis
relationship: part_of GO:0072273 ! metanephric nephron morphogenesis
created_by: pr
creation_date: 2012-07-13T02:41:12Z

[Term]
id: GO:1901148
name: gene expression involved in extracellular matrix organization
namespace: biological_process
def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558]
synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf]
synonym: "extracellular matrix protein production" RELATED [GOC:pg]
is_a: GO:0010467 ! gene expression
intersection_of: GO:0010467 ! gene expression
intersection_of: part_of GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0030198 ! extracellular matrix organization
created_by: bf
creation_date: 2012-07-16T03:29:30Z

[Term]
id: GO:1901160
name: primary amino compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:50994 ! primary amino compound
relationship: has_primary_input_or_output CHEBI:50994 ! primary amino compound
created_by: bf
creation_date: 2012-07-18T04:44:39Z

[Term]
id: GO:1901161
name: primary amino compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie]
synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901160 ! primary amino compound metabolic process
is_a: GO:1901565 ! organonitrogen compound catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:50994 ! primary amino compound
relationship: has_primary_input CHEBI:50994 ! primary amino compound
created_by: bf
creation_date: 2012-07-18T04:45:06Z

[Term]
id: GO:1901162
name: primary amino compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie]
synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie]
synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "primary amino compound formation" EXACT [GOC:TermGenie]
synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901160 ! primary amino compound metabolic process
is_a: GO:1901566 ! organonitrogen compound biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:50994 ! primary amino compound
relationship: has_primary_output CHEBI:50994 ! primary amino compound
created_by: bf
creation_date: 2012-07-18T04:45:14Z

[Term]
id: GO:1901163
name: regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061450 ! trophoblast cell migration
relationship: regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:06Z

[Term]
id: GO:1901164
name: negative regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061450 ! trophoblast cell migration
relationship: negatively_regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:28Z

[Term]
id: GO:1901165
name: positive regulation of trophoblast cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie]
synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901163 ! regulation of trophoblast cell migration
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061450 ! trophoblast cell migration
relationship: positively_regulates GO:0061450 ! trophoblast cell migration
created_by: vk
creation_date: 2012-07-19T07:53:35Z

[Term]
id: GO:1901166
name: neural crest cell migration involved in autonomic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie]
is_a: GO:0001755 ! neural crest cell migration
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0048483 ! autonomic nervous system development
relationship: part_of GO:0048483 ! autonomic nervous system development
created_by: vk
creation_date: 2012-07-19T08:39:56Z

[Term]
id: GO:1901190
name: regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0043254 ! regulation of protein-containing complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:26:58Z

[Term]
id: GO:1901191
name: negative regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031333 ! negative regulation of protein-containing complex assembly
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:27:21Z

[Term]
id: GO:1901192
name: positive regulation of formation of translation initiation ternary complex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie]
synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie]
synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie]
synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie]
is_a: GO:0031334 ! positive regulation of protein-containing complex assembly
is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001677 ! formation of translation initiation ternary complex
relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex
created_by: ss
creation_date: 2012-07-25T02:27:29Z

[Term]
id: GO:1901201
name: regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0085029 ! extracellular matrix assembly
relationship: regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:00Z

[Term]
id: GO:1901202
name: negative regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie]
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0085029 ! extracellular matrix assembly
relationship: negatively_regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:24Z

[Term]
id: GO:1901203
name: positive regulation of extracellular matrix assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie]
synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1901201 ! regulation of extracellular matrix assembly
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0085029 ! extracellular matrix assembly
relationship: positively_regulates GO:0085029 ! extracellular matrix assembly
created_by: rl
creation_date: 2012-07-27T04:04:32Z

[Term]
id: GO:1901210
name: regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003207 ! cardiac chamber formation
relationship: regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:18:35Z

[Term]
id: GO:1901211
name: negative regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901210 ! regulation of cardiac chamber formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003207 ! cardiac chamber formation
relationship: negatively_regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:18:57Z

[Term]
id: GO:1901212
name: positive regulation of cardiac chamber formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie]
is_a: GO:1901210 ! regulation of cardiac chamber formation
is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003207 ! cardiac chamber formation
relationship: positively_regulates GO:0003207 ! cardiac chamber formation
created_by: rl
creation_date: 2012-07-31T07:19:05Z

[Term]
id: GO:1901219
name: regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:11Z

[Term]
id: GO:1901220
name: negative regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:34Z

[Term]
id: GO:1901221
name: positive regulation of cardiac chamber morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie]
synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003206 ! cardiac chamber morphogenesis
relationship: positively_regulates GO:0003206 ! cardiac chamber morphogenesis
created_by: rl
creation_date: 2012-08-06T17:59:42Z

[Term]
id: GO:1901246
name: regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061141 ! lung ciliated cell differentiation
relationship: regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:58:34Z

[Term]
id: GO:1901247
name: negative regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061141 ! lung ciliated cell differentiation
relationship: negatively_regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:58:58Z

[Term]
id: GO:1901248
name: positive regulation of lung ciliated cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901246 ! regulation of lung ciliated cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061141 ! lung ciliated cell differentiation
relationship: positively_regulates GO:0061141 ! lung ciliated cell differentiation
created_by: vk
creation_date: 2012-08-08T08:59:05Z

[Term]
id: GO:1901264
name: carbohydrate derivative transport
namespace: biological_process
def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative
relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative
created_by: bf
creation_date: 2012-08-16T14:51:22Z

[Term]
id: GO:1901317
name: regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "regulation of sperm motility" BROAD []
synonym: "regulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030317 ! flagellated sperm motility
relationship: regulates GO:0030317 ! flagellated sperm motility
created_by: hjd
creation_date: 2012-08-22T20:50:14Z

[Term]
id: GO:1901318
name: negative regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]
synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie]
synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie]
synonym: "negative regulation of sperm motility" BROAD []
synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0003354 ! negative regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030317 ! flagellated sperm motility
relationship: negatively_regulates GO:0030317 ! flagellated sperm motility
created_by: hjd
creation_date: 2012-08-22T20:50:35Z

[Term]
id: GO:1901342
name: regulation of vasculature development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001944 ! vasculature development
relationship: regulates GO:0001944 ! vasculature development
created_by: bf
creation_date: 2012-09-06T09:16:15Z

[Term]
id: GO:1901343
name: negative regulation of vasculature development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie]
synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie]
synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001944 ! vasculature development
relationship: negatively_regulates GO:0001944 ! vasculature development
created_by: bf
creation_date: 2012-09-06T09:17:24Z

[Term]
id: GO:1901360
name: organic cyclic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33832 ! organic cyclic compound
relationship: has_primary_input_or_output CHEBI:33832 ! organic cyclic compound
created_by: bf
creation_date: 2012-09-14T09:03:51Z

[Term]
id: GO:1901361
name: organic cyclic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33832 ! organic cyclic compound
relationship: has_primary_input CHEBI:33832 ! organic cyclic compound
created_by: bf
creation_date: 2012-09-14T09:05:04Z

[Term]
id: GO:1901362
name: organic cyclic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]
synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie]
synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901360 ! organic cyclic compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33832 ! organic cyclic compound
relationship: has_primary_output CHEBI:33832 ! organic cyclic compound
created_by: bf
creation_date: 2012-09-14T09:05:22Z

[Term]
id: GO:1901374
name: acetate ester transport
namespace: biological_process
def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie]
is_a: GO:0071702 ! organic substance transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:47622 ! acetate ester
relationship: has_primary_input CHEBI:47622 ! acetate ester
created_by: bf
creation_date: 2012-09-28T10:42:13Z

[Term]
id: GO:1901375
name: acetate ester transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:47622 ! acetate ester
relationship: has_primary_input CHEBI:47622 ! acetate ester
relationship: part_of GO:1901374 ! acetate ester transport
created_by: bf
creation_date: 2012-09-28T10:47:08Z

[Term]
id: GO:1901382
name: regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:03:13Z

[Term]
id: GO:1901383
name: negative regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:04:23Z

[Term]
id: GO:1901384
name: positive regulation of chorionic trophoblast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie]
synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation
created_by: vk
creation_date: 2012-10-01T10:04:41Z

[Term]
id: GO:1901401
name: regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:34:03Z

[Term]
id: GO:1901402
name: negative regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:35:11Z

[Term]
id: GO:1901403
name: positive regulation of tetrapyrrole metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033013 ! tetrapyrrole metabolic process
relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process
created_by: tt
creation_date: 2012-10-01T14:35:29Z

[Term]
id: GO:1901404
name: regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:38:12Z

[Term]
id: GO:1901405
name: negative regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:39:22Z

[Term]
id: GO:1901406
name: positive regulation of tetrapyrrole catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033015 ! tetrapyrrole catabolic process
relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process
created_by: tt
creation_date: 2012-10-01T14:39:40Z

[Term]
id: GO:1901457
name: regulation of response to acetate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010034 ! response to acetate
relationship: regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:25:06Z

[Term]
id: GO:1901458
name: negative regulation of response to acetate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010034 ! response to acetate
relationship: negatively_regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:26:15Z

[Term]
id: GO:1901459
name: positive regulation of response to acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of response to acetate" NARROW [GOC:TermGenie]
synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie]
synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:1901457 ! regulation of response to acetate
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010034 ! response to acetate
relationship: positively_regulates GO:0010034 ! response to acetate
created_by: tt
creation_date: 2012-10-02T14:26:34Z

[Term]
id: GO:1901463
name: regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:34:14Z

[Term]
id: GO:1901464
name: negative regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:35:26Z

[Term]
id: GO:1901465
name: positive regulation of tetrapyrrole biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie]
synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie]
synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process
is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
relationship: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process
created_by: tt
creation_date: 2012-10-02T14:35:43Z

[Term]
id: GO:1901505
name: carbohydrate derivative transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "carbohydrate derivative transporter activity" RELATED []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:63299 ! carbohydrate derivative
relationship: has_primary_input CHEBI:63299 ! carbohydrate derivative
relationship: part_of GO:1901264 {http://purl.org/dc/terms/source="GO_REF:0000090"} ! carbohydrate derivative transport
created_by: pr
creation_date: 2012-10-17T10:31:22Z

[Term]
id: GO:1901509
name: regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie]
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061154 ! endothelial tube morphogenesis
relationship: regulates GO:0061154 ! endothelial tube morphogenesis
created_by: dph
creation_date: 2012-10-17T14:30:40Z

[Term]
id: GO:1901532
name: regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:01Z

[Term]
id: GO:1901533
name: negative regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:06Z

[Term]
id: GO:1901534
name: positive regulation of hematopoietic progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]
synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT []
synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
relationship: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation
created_by: vk
creation_date: 2012-10-24T11:23:14Z

[Term]
id: GO:1901550
name: regulation of endothelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
is_a: GO:0045601 ! regulation of endothelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001885 ! endothelial cell development
relationship: regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:50Z

[Term]
id: GO:1901551
name: negative regulation of endothelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0045602 ! negative regulation of endothelial cell differentiation
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001885 ! endothelial cell development
relationship: negatively_regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:54Z

[Term]
id: GO:1901552
name: positive regulation of endothelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579]
synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1901550 ! regulation of endothelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001885 ! endothelial cell development
relationship: positively_regulates GO:0001885 ! endothelial cell development
created_by: pr
creation_date: 2012-10-30T12:59:58Z

[Term]
id: GO:1901564
name: organonitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]
subset: gocheck_do_not_annotate
synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound
relationship: has_primary_input_or_output CHEBI:35352 ! organonitrogen compound
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/26424" xsd:anyURI
created_by: pr
creation_date: 2012-11-04T15:17:52Z

[Term]
id: GO:1901565
name: organonitrogen compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]
synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901575 ! organic substance catabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:35352 ! organonitrogen compound
relationship: has_primary_input CHEBI:35352 ! organonitrogen compound
created_by: pr
creation_date: 2012-11-04T15:17:56Z

[Term]
id: GO:1901566
name: organonitrogen compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]
synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie]
synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901564 ! organonitrogen compound metabolic process
is_a: GO:1901576 ! organic substance biosynthetic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:35352 ! organonitrogen compound
relationship: has_primary_output CHEBI:35352 ! organonitrogen compound
created_by: pr
creation_date: 2012-11-04T15:18:00Z

[Term]
id: GO:1901575
name: organic substance catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie]
synonym: "organic molecular entity catabolic process" EXACT []
synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie]
synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie]
synonym: "organic substance breakdown" EXACT []
synonym: "organic substance catabolism" EXACT []
synonym: "organic substance degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:50860 ! organic molecular entity
relationship: has_primary_input CHEBI:50860 ! organic molecular entity
created_by: pr
creation_date: 2012-11-05T11:04:36Z

[Term]
id: GO:1901576
name: organic substance biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]
synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic molecular entity biosynthetic process" EXACT []
synonym: "organic molecular entity formation" EXACT [GOC:TermGenie]
synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie]
synonym: "organic substance anabolism" EXACT []
synonym: "organic substance biosynthesis" EXACT []
synonym: "organic substance formation" EXACT []
synonym: "organic substance synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:50860 ! organic molecular entity
relationship: has_primary_output CHEBI:50860 ! organic molecular entity
created_by: pr
creation_date: 2012-11-05T11:04:40Z

[Term]
id: GO:1901605
name: alpha-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0006520 ! amino acid metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:78608 ! alpha-amino acid zwitterion
relationship: has_primary_input_or_output CHEBI:78608 ! alpha-amino acid zwitterion
created_by: tb
creation_date: 2012-11-08T17:39:50Z

[Term]
id: GO:1901606
name: alpha-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie]
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:78608 ! alpha-amino acid zwitterion
relationship: has_primary_input CHEBI:78608 ! alpha-amino acid zwitterion
created_by: tb
creation_date: 2012-11-08T17:39:54Z

[Term]
id: GO:1901607
name: alpha-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]
synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie]
synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1901605 ! alpha-amino acid metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:78608 ! alpha-amino acid zwitterion
relationship: has_primary_output CHEBI:78608 ! alpha-amino acid zwitterion
created_by: tb
creation_date: 2012-11-08T17:39:58Z

[Term]
id: GO:1901608
name: regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0047496 ! vesicle transport along microtubule
relationship: regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:44Z

[Term]
id: GO:1901609
name: negative regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0047496 ! vesicle transport along microtubule
relationship: negatively_regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:48Z

[Term]
id: GO:1901610
name: positive regulation of vesicle transport along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie]
synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie]
synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1901608 ! regulation of vesicle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0047496 ! vesicle transport along microtubule
relationship: positively_regulates GO:0047496 ! vesicle transport along microtubule
created_by: hjd
creation_date: 2012-11-08T21:49:53Z

[Term]
id: GO:1901615
name: organic hydroxy compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie]
is_a: GO:0071704 ! organic substance metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:33822 ! organic hydroxy compound
relationship: has_primary_input_or_output CHEBI:33822 ! organic hydroxy compound
created_by: pr
creation_date: 2012-11-13T12:54:27Z

[Term]
id: GO:1901616
name: organic hydroxy compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie]
is_a: GO:1901575 ! organic substance catabolic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
intersection_of: GO:0009056 ! catabolic process
intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound
relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound
created_by: pr
creation_date: 2012-11-13T12:54:31Z

[Term]
id: GO:1901617
name: organic hydroxy compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]
synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie]
synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie]
is_a: GO:1901576 ! organic substance biosynthetic process
is_a: GO:1901615 ! organic hydroxy compound metabolic process
intersection_of: GO:0009058 ! biosynthetic process
intersection_of: has_primary_output CHEBI:33822 ! organic hydroxy compound
relationship: has_primary_output CHEBI:33822 ! organic hydroxy compound
created_by: pr
creation_date: 2012-11-13T12:54:36Z

[Term]
id: GO:1901618
name: organic hydroxy compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:33822 ! organic hydroxy compound
relationship: has_primary_input CHEBI:33822 ! organic hydroxy compound
created_by: pr
creation_date: 2012-11-13T12:59:01Z

[Term]
id: GO:1901652
name: response to peptide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]
is_a: GO:0010243 ! response to organonitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:16670 ! peptide
relationship: has_primary_input CHEBI:16670 ! peptide
created_by: pr
creation_date: 2012-11-20T09:45:15Z

[Term]
id: GO:1901654
name: response to ketone
namespace: biological_process
alt_id: GO:1990369
def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676]
synonym: "process resulting in tolerance to ketone" NARROW []
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:17087 ! ketone
relationship: has_primary_input CHEBI:17087 ! ketone
created_by: pr
creation_date: 2012-11-20T10:55:47Z

[Term]
id: GO:1901682
name: sulfur compound transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
synonym: "sulfur molecular entity transmembrane transporter activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:26835 ! sulfur molecular entity
relationship: has_primary_input CHEBI:26835 ! sulfur molecular entity
created_by: pr
creation_date: 2012-11-26T20:45:29Z

[Term]
id: GO:1901692
name: regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:35Z

[Term]
id: GO:1901693
name: negative regulation of compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:40Z

[Term]
id: GO:1901694
name: positive regulation of compound eye retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046675
def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768]
synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "induction of compound eye retinal cell programmed cell death" RELATED []
synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death
is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
relationship: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process
created_by: pr
creation_date: 2012-12-12T10:28:45Z

[Term]
id: GO:1901698
name: response to nitrogen compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "response to nitrogen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:51143 ! nitrogen molecular entity
relationship: has_primary_input CHEBI:51143 ! nitrogen molecular entity
created_by: pr
creation_date: 2012-12-13T15:06:08Z

[Term]
id: GO:1901700
name: response to oxygen-containing compound
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]
synonym: "response to oxygen molecular entity" EXACT []
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:25806 ! oxygen molecular entity
relationship: has_primary_input CHEBI:25806 ! oxygen molecular entity
created_by: pr
creation_date: 2012-12-13T15:11:37Z

[Term]
id: GO:1901702
name: salt transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]
is_a: GO:0022857 ! transmembrane transporter activity
intersection_of: GO:0022857 ! transmembrane transporter activity
intersection_of: has_primary_input CHEBI:24866 ! salt
relationship: has_primary_input CHEBI:24866 ! salt
created_by: pr
creation_date: 2012-12-13T15:14:47Z

[Term]
id: GO:1901706
name: mesenchymal cell differentiation involved in bone development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0060348 ! bone development
relationship: part_of GO:0060348 ! bone development
created_by: hjd
creation_date: 2012-12-14T16:04:16Z

[Term]
id: GO:1901722
name: regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:31Z

[Term]
id: GO:1901723
name: negative regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:35Z

[Term]
id: GO:1901724
name: positive regulation of cell proliferation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616]
synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072111 ! cell proliferation involved in kidney development
relationship: positively_regulates GO:0072111 ! cell proliferation involved in kidney development
created_by: krc
creation_date: 2012-12-27T19:30:40Z

[Term]
id: GO:1901861
name: regulation of muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060537 ! muscle tissue development
relationship: regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:47Z

[Term]
id: GO:1901862
name: negative regulation of muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060537 ! muscle tissue development
relationship: negatively_regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:52Z

[Term]
id: GO:1901863
name: positive regulation of muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]
synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060537 ! muscle tissue development
relationship: positively_regulates GO:0060537 ! muscle tissue development
created_by: yaf
creation_date: 2013-02-01T10:30:57Z

[Term]
id: GO:1901879
name: regulation of protein depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043244 ! regulation of protein-containing complex disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051261 ! protein depolymerization
relationship: regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:23Z

[Term]
id: GO:1901880
name: negative regulation of protein depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051261 ! protein depolymerization
relationship: negatively_regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:28Z

[Term]
id: GO:1901881
name: positive regulation of protein depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137]
synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie]
synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie]
is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly
is_a: GO:1901879 ! regulation of protein depolymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051261 ! protein depolymerization
relationship: positively_regulates GO:0051261 ! protein depolymerization
created_by: rl
creation_date: 2013-02-06T13:57:32Z

[Term]
id: GO:1901888
name: regulation of cell junction assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0034329 ! cell junction assembly
relationship: regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:32Z

[Term]
id: GO:1901889
name: negative regulation of cell junction assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0034329 ! cell junction assembly
relationship: negatively_regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:41Z

[Term]
id: GO:1901890
name: positive regulation of cell junction assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]
synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1901888 ! regulation of cell junction assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0034329 ! cell junction assembly
relationship: positively_regulates GO:0034329 ! cell junction assembly
created_by: tb
creation_date: 2013-02-06T19:40:46Z

[Term]
id: GO:1901963
name: regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-02-20T20:30:26Z

[Term]
id: GO:1901964
name: positive regulation of cell proliferation involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760]
synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
relationship: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-02-20T20:30:31Z

[Term]
id: GO:1902017
name: regulation of cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060271 ! cilium assembly
relationship: regulates GO:0060271 ! cilium assembly
created_by: dph
creation_date: 2013-03-26T18:10:51Z

[Term]
id: GO:1902018
name: negative regulation of cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]
synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1902017 ! regulation of cilium assembly
is_a: GO:1902116 ! negative regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060271 ! cilium assembly
relationship: negatively_regulates GO:0060271 ! cilium assembly
created_by: dph
creation_date: 2013-03-26T18:10:56Z

[Term]
id: GO:1902019
name: regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "regulation of ciliary cell motility" RELATED []
synonym: "regulation of cilium cell motility" EXACT []
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060285 ! cilium-dependent cell motility
relationship: regulates GO:0060285 ! cilium-dependent cell motility
created_by: jl
creation_date: 2013-03-27T14:42:38Z

[Term]
id: GO:1902020
name: negative regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie]
synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie]
synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie]
synonym: "negative regulation of ciliary cell motility" RELATED []
synonym: "negative regulation of cilium cell motility" EXACT []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000146 ! negative regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060285 ! cilium-dependent cell motility
relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility
created_by: jl
creation_date: 2013-03-27T14:42:42Z

[Term]
id: GO:1902033
name: regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:19Z

[Term]
id: GO:1902034
name: negative regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:1903707 ! negative regulation of hemopoiesis
is_a: GO:2000647 ! negative regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:24Z

[Term]
id: GO:1902035
name: positive regulation of hematopoietic stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation
is_a: GO:2000648 ! positive regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation
relationship: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation
created_by: ss
creation_date: 2013-04-02T05:13:31Z

[Term]
id: GO:1902036
name: regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:09Z

[Term]
id: GO:1902037
name: negative regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:14Z

[Term]
id: GO:1902038
name: positive regulation of hematopoietic stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623]
synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation
relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation
created_by: ss
creation_date: 2013-04-02T05:19:19Z

[Term]
id: GO:1902074
name: response to salt
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]
synonym: "response to salinity" NARROW [GOC:mls]
is_a: GO:0042221 ! response to chemical
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:24866 ! salt
relationship: has_primary_input CHEBI:24866 ! salt
created_by: mls
creation_date: 2013-04-22T15:41:57Z

[Term]
id: GO:1902093
name: positive regulation of flagellated sperm motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]
synonym: "activation of sperm motility" NARROW [GOC:TermGenie]
synonym: "activation of sperm movement" BROAD [GOC:TermGenie]
synonym: "positive regulation of sperm motility" BROAD []
synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie]
synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie]
is_a: GO:0003353 ! positive regulation of cilium movement
is_a: GO:1901317 ! regulation of flagellated sperm motility
is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030317 ! flagellated sperm motility
relationship: positively_regulates GO:0030317 ! flagellated sperm motility
created_by: bf
creation_date: 2013-04-29T09:15:25Z

[Term]
id: GO:1902105
name: regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002521 ! leukocyte differentiation
relationship: regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:42Z

[Term]
id: GO:1902106
name: negative regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903707 ! negative regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002521 ! leukocyte differentiation
relationship: negatively_regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:47Z

[Term]
id: GO:1902107
name: positive regulation of leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie]
synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie]
is_a: GO:1902105 ! regulation of leukocyte differentiation
is_a: GO:1903708 ! positive regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002521 ! leukocyte differentiation
relationship: positively_regulates GO:0002521 ! leukocyte differentiation
created_by: pr
creation_date: 2013-05-02T17:32:52Z

[Term]
id: GO:1902115
name: regulation of organelle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070925 ! organelle assembly
relationship: regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:21Z

[Term]
id: GO:1902116
name: negative regulation of organelle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070925 ! organelle assembly
relationship: negatively_regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:31Z

[Term]
id: GO:1902117
name: positive regulation of organelle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]
synonym: "activation of organelle assembly" NARROW [GOC:TermGenie]
synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070925 ! organelle assembly
relationship: positively_regulates GO:0070925 ! organelle assembly
created_by: pr
creation_date: 2013-05-14T09:43:36Z

[Term]
id: GO:1902217
name: erythrocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033028 ! myeloid cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000232 ! erythrocyte
relationship: occurs_in CL:0000232 ! erythrocyte
property_value: RO:0002161 NCBITaxon:4751
created_by: rl
creation_date: 2013-06-13T10:02:29Z

[Term]
id: GO:1902250
name: regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033032 ! regulation of myeloid cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902217 ! erythrocyte apoptotic process
relationship: regulates GO:1902217 ! erythrocyte apoptotic process
created_by: rl
creation_date: 2013-06-20T19:30:53Z

[Term]
id: GO:1902251
name: negative regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902217 ! erythrocyte apoptotic process
relationship: negatively_regulates GO:1902217 ! erythrocyte apoptotic process
property_value: RO:0002161 NCBITaxon:4751
created_by: rl
creation_date: 2013-06-20T19:30:59Z

[Term]
id: GO:1902252
name: positive regulation of erythrocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084]
synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process
is_a: GO:1902250 ! regulation of erythrocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902217 ! erythrocyte apoptotic process
relationship: positively_regulates GO:1902217 ! erythrocyte apoptotic process
property_value: RO:0002161 NCBITaxon:4751
created_by: rl
creation_date: 2013-06-20T19:31:04Z

[Term]
id: GO:1902256
name: regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:24Z

[Term]
id: GO:1902257
name: negative regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:30Z

[Term]
id: GO:1902258
name: positive regulation of apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542]
synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis
is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
relationship: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis
created_by: dph
creation_date: 2013-06-24T19:12:42Z

[Term]
id: GO:1902262
name: apoptotic process involved in blood vessel morphogenesis
namespace: biological_process
def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358]
synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie]
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis
created_by: dph
creation_date: 2013-06-25T16:16:00Z

[Term]
id: GO:1902275
name: regulation of chromatin organization
namespace: biological_process
alt_id: GO:0001672
alt_id: GO:1903308
def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]
synonym: "regulation of chromatin assembly or disassembly" RELATED []
synonym: "regulation of chromatin assembly/disassembly" RELATED []
synonym: "regulation of chromatin modification" RELATED []
synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006325 ! chromatin organization
relationship: regulates GO:0006325 ! chromatin organization
created_by: bf
creation_date: 2013-07-01T13:21:52Z

[Term]
id: GO:1902305
name: regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035725 ! sodium ion transmembrane transport
relationship: regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:33:53Z

[Term]
id: GO:1902306
name: negative regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010766 ! negative regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904063 ! negative regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035725 ! sodium ion transmembrane transport
relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:34:01Z

[Term]
id: GO:1902307
name: positive regulation of sodium ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]
synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0010765 ! positive regulation of sodium ion transport
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
is_a: GO:1904064 ! positive regulation of cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035725 ! sodium ion transmembrane transport
relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport
created_by: rl
creation_date: 2013-07-18T13:34:18Z

[Term]
id: GO:1902337
name: regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:16Z

[Term]
id: GO:1902338
name: negative regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904746 ! negative regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:25Z

[Term]
id: GO:1902339
name: positive regulation of apoptotic process involved in morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035]
synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie]
is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis
is_a: GO:1904747 ! positive regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis
created_by: sart
creation_date: 2013-07-29T15:03:33Z

[Term]
id: GO:1902340
name: negative regulation of chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725]
synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001251 ! negative regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030261 ! chromosome condensation
relationship: negatively_regulates GO:0030261 ! chromosome condensation
created_by: dgf
creation_date: 2013-07-29T20:54:14Z

[Term]
id: GO:1902358
name: sulfate transmembrane transport
namespace: biological_process
def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073]
is_a: GO:0008272 ! sulfate transport
is_a: GO:0098661 ! inorganic anion transmembrane transport
intersection_of: GO:0055085 ! transmembrane transport
intersection_of: has_primary_input CHEBI:16189 ! sulfate
created_by: dph
creation_date: 2013-08-14T14:46:04Z

[Term]
id: GO:1902369
name: negative regulation of RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]
synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006401 ! RNA catabolic process
relationship: negatively_regulates GO:0006401 ! RNA catabolic process
created_by: bf
creation_date: 2013-08-22T14:59:39Z

[Term]
id: GO:1902414
name: protein localization to cell junction
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111]
synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie]
synonym: "protein localization in cell junction" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0030054 ! cell junction
relationship: has_target_end_location GO:0030054 ! cell junction
created_by: tb
creation_date: 2013-09-13T16:55:57Z

[Term]
id: GO:1902455
name: negative regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019827 ! stem cell population maintenance
relationship: negatively_regulates GO:0019827 ! stem cell population maintenance
created_by: cjm
creation_date: 2013-10-16T22:19:17Z

[Term]
id: GO:1902459
name: positive regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033]
synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie]
synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000036 ! regulation of stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019827 ! stem cell population maintenance
relationship: positively_regulates GO:0019827 ! stem cell population maintenance
created_by: cjm
creation_date: 2013-10-16T22:27:47Z

[Term]
id: GO:1902463
name: protein localization to cell leading edge
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326]
synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0031252 ! cell leading edge
relationship: has_target_end_location GO:0031252 ! cell leading edge
created_by: jl
creation_date: 2013-10-22T12:36:07Z

[Term]
id: GO:1902473
name: regulation of protein localization to synapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035418 ! protein localization to synapse
relationship: regulates GO:0035418 ! protein localization to synapse
created_by: kmv
creation_date: 2013-10-25T15:09:09Z

[Term]
id: GO:1902474
name: positive regulation of protein localization to synapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719]
synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035418 ! protein localization to synapse
relationship: positively_regulates GO:0035418 ! protein localization to synapse
created_by: kmv
creation_date: 2013-10-25T15:09:18Z

[Term]
id: GO:1902484
name: Sertoli cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895]
synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000216 ! Sertoli cell
relationship: occurs_in CL:0000216 ! Sertoli cell
created_by: pr
creation_date: 2013-11-06T11:27:34Z

[Term]
id: GO:1902488
name: cholangiocyte apoptotic process
namespace: biological_process
def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800]
synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904019 ! epithelial cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:1000488 ! cholangiocyte
relationship: occurs_in CL:1000488 ! cholangiocyte
created_by: cls
creation_date: 2013-11-12T15:30:08Z

[Term]
id: GO:1902489
name: hepatoblast apoptotic process
namespace: biological_process
def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967]
synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0005026 ! hepatoblast
relationship: occurs_in CL:0005026 ! hepatoblast
created_by: cls
creation_date: 2013-11-12T17:02:52Z

[Term]
id: GO:1902490
name: regulation of sperm capacitation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:1903429 ! regulation of cell maturation
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048240 ! sperm capacitation
relationship: regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:03Z

[Term]
id: GO:1902491
name: negative regulation of sperm capacitation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie]
synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903430 ! negative regulation of cell maturation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048240 ! sperm capacitation
relationship: negatively_regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:12Z

[Term]
id: GO:1902492
name: positive regulation of sperm capacitation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676]
synonym: "activation of sperm activation" RELATED [GOC:TermGenie]
synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie]
synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie]
synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie]
synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902490 ! regulation of sperm capacitation
is_a: GO:1903431 ! positive regulation of cell maturation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048240 ! sperm capacitation
relationship: positively_regulates GO:0048240 ! sperm capacitation
created_by: hjd
creation_date: 2013-11-12T21:17:21Z

[Term]
id: GO:1902494
name: catalytic complex
namespace: cellular_component
def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]
subset: goslim_metagenomics
synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl]
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of GO:0003824 ! catalytic activity
relationship: capable_of GO:0003824 ! catalytic activity
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/19980" xsd:anyURI
created_by: bhm
creation_date: 2013-11-13T16:18:47Z

[Term]
id: GO:1902495
name: transmembrane transporter complex
namespace: cellular_component
def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]
is_a: GO:0098796 ! membrane protein complex
is_a: GO:1990351 ! transporter complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of GO:0022857 ! transmembrane transporter activity
relationship: capable_of GO:0022857 ! transmembrane transporter activity
created_by: bhm
creation_date: 2013-11-13T16:23:04Z

[Term]
id: GO:1902510
name: regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341]
comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie]
synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie]
synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:32Z

[Term]
id: GO:1902511
name: negative regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903625 ! negative regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:41Z

[Term]
id: GO:1902512
name: positive regulation of apoptotic DNA fragmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351]
synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie]
synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie]
synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie]
is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation
is_a: GO:1903626 ! positive regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006309 ! apoptotic DNA fragmentation
relationship: positively_regulates GO:0006309 ! apoptotic DNA fragmentation
created_by: hjd
creation_date: 2013-11-15T18:28:50Z

[Term]
id: GO:1902513
name: regulation of organelle transport along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087]
synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072384 ! organelle transport along microtubule
relationship: regulates GO:0072384 ! organelle transport along microtubule
created_by: dph
creation_date: 2013-11-15T20:15:17Z

[Term]
id: GO:1902531
name: regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010627
def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "regulation of intracellular protein kinase cascade" NARROW []
synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035556 ! intracellular signal transduction
relationship: regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:32:52Z

[Term]
id: GO:1902532
name: negative regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010741
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular protein kinase cascade" EXACT []
synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035556 ! intracellular signal transduction
relationship: negatively_regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:33:01Z

[Term]
id: GO:1902533
name: positive regulation of intracellular signal transduction
namespace: biological_process
alt_id: GO:0010740
def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]
synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie]
synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular protein kinase cascade" NARROW []
synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie]
synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie]
synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie]
synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:1902531 ! regulation of intracellular signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035556 ! intracellular signal transduction
relationship: positively_regulates GO:0035556 ! intracellular signal transduction
created_by: bf
creation_date: 2013-12-02T11:33:10Z

[Term]
id: GO:1902570
name: protein localization to nucleolus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626]
synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:0034504 ! protein localization to nucleus
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005730 ! nucleolus
relationship: has_target_end_location GO:0005730 ! nucleolus
created_by: mah
creation_date: 2013-12-10T16:25:28Z

[Term]
id: GO:1902679
name: negative regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie]
synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process
relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process
created_by: jl
creation_date: 2014-02-05T16:32:01Z

[Term]
id: GO:1902680
name: positive regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]
synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of RNA formation" NARROW [GOC:TermGenie]
synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie]
synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:2001141 ! regulation of RNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process
relationship: positively_regulates GO:0032774 ! RNA biosynthetic process
created_by: jl
creation_date: 2014-02-05T16:32:10Z

[Term]
id: GO:1902692
name: regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007405 ! neuroblast proliferation
relationship: regulates GO:0007405 ! neuroblast proliferation
created_by: rl
creation_date: 2014-02-18T10:03:31Z

[Term]
id: GO:1902738
name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546]
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:1903010 ! regulation of bone development
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
created_by: mr
creation_date: 2014-02-26T15:36:15Z

[Term]
id: GO:1902742
name: apoptotic process involved in development
namespace: biological_process
def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic process involved in anatomical structure development" EXACT []
synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0048856 ! anatomical structure development
relationship: part_of GO:0048856 ! anatomical structure development
created_by: pr
creation_date: 2014-02-28T13:09:43Z

[Term]
id: GO:1902761
name: positive regulation of chondrocyte development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901]
synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie]
synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie]
synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0032332 ! positive regulation of chondrocyte differentiation
is_a: GO:0061181 ! regulation of chondrocyte development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002063 ! chondrocyte development
relationship: positively_regulates GO:0002063 ! chondrocyte development
created_by: mr
creation_date: 2014-03-07T17:45:55Z

[Term]
id: GO:1902809
name: regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:26Z

[Term]
id: GO:1902810
name: negative regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
is_a: GO:0010832 ! negative regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:32Z

[Term]
id: GO:1902811
name: positive regulation of skeletal muscle fiber differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321]
synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie]
is_a: GO:0010831 ! positive regulation of myotube differentiation
is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation
is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation
relationship: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation
created_by: mr
creation_date: 2014-03-26T21:18:38Z

[Term]
id: GO:1902816
name: regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035372 ! protein localization to microtubule
relationship: regulates GO:0035372 ! protein localization to microtubule
created_by: tb
creation_date: 2014-03-27T22:07:12Z

[Term]
id: GO:1902817
name: negative regulation of protein localization to microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209]
synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie]
is_a: GO:1902816 ! regulation of protein localization to microtubule
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035372 ! protein localization to microtubule
relationship: negatively_regulates GO:0035372 ! protein localization to microtubule
created_by: tb
creation_date: 2014-03-27T22:07:18Z

[Term]
id: GO:1902838
name: regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie]
synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie]
synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:1902513 ! regulation of organelle transport along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030473 ! nuclear migration along microtubule
relationship: regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:23Z

[Term]
id: GO:1902839
name: negative regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030473 ! nuclear migration along microtubule
relationship: negatively_regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:29Z

[Term]
id: GO:1902840
name: positive regulation of nuclear migration along microtubule
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209]
synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie]
synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie]
synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie]
synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie]
synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1902838 ! regulation of nuclear migration along microtubule
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030473 ! nuclear migration along microtubule
relationship: positively_regulates GO:0030473 ! nuclear migration along microtubule
created_by: vw
creation_date: 2014-04-01T13:50:35Z

[Term]
id: GO:1902850
name: microtubule cytoskeleton organization involved in mitosis
namespace: biological_process
def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626]
synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie]
synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie]
synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:1903047 ! mitotic cell cycle process
intersection_of: GO:0000226 ! microtubule cytoskeleton organization
intersection_of: part_of GO:0000278 ! mitotic cell cycle
created_by: vw
creation_date: 2014-04-02T14:19:38Z

[Term]
id: GO:1902863
name: regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031076 ! embryonic camera-type eye development
relationship: regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:00Z

[Term]
id: GO:1902864
name: negative regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031076 ! embryonic camera-type eye development
relationship: negatively_regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:06Z

[Term]
id: GO:1902865
name: positive regulation of embryonic camera-type eye development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie]
synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie]
synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie]
synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1902863 ! regulation of embryonic camera-type eye development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031076 ! embryonic camera-type eye development
relationship: positively_regulates GO:0031076 ! embryonic camera-type eye development
created_by: mr
creation_date: 2014-04-03T15:24:12Z

[Term]
id: GO:1902866
name: regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060041 ! retina development in camera-type eye
relationship: regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:17Z

[Term]
id: GO:1902867
name: negative regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "downregulation of retinal development" RELATED [GOC:TermGenie]
synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "inhibition of retinal development" RELATED [GOC:TermGenie]
synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060041 ! retina development in camera-type eye
relationship: negatively_regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:23Z

[Term]
id: GO:1902868
name: positive regulation of retina development in camera-type eye
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie]
synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie]
synonym: "activation of retinal development" RELATED [GOC:TermGenie]
synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie]
synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie]
synonym: "upregulation of retinal development" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902866 ! regulation of retina development in camera-type eye
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060041 ! retina development in camera-type eye
relationship: positively_regulates GO:0060041 ! retina development in camera-type eye
created_by: mr
creation_date: 2014-04-03T15:24:29Z

[Term]
id: GO:1902875
name: regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie]
synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie]
synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009880 ! embryonic pattern specification
relationship: regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:15Z

[Term]
id: GO:1902876
name: negative regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009880 ! embryonic pattern specification
relationship: negatively_regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:20Z

[Term]
id: GO:1902877
name: positive regulation of embryonic pattern specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597]
synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie]
synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie]
synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie]
synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1902875 ! regulation of embryonic pattern specification
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009880 ! embryonic pattern specification
relationship: positively_regulates GO:0009880 ! embryonic pattern specification
created_by: mr
creation_date: 2014-04-03T15:25:26Z

[Term]
id: GO:1902903
name: regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097435 ! supramolecular fiber organization
relationship: regulates GO:0097435 ! supramolecular fiber organization
created_by: rl
creation_date: 2014-04-15T16:46:36Z

[Term]
id: GO:1902904
name: negative regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097435 ! supramolecular fiber organization
relationship: negatively_regulates GO:0097435 ! supramolecular fiber organization
created_by: rl
creation_date: 2014-04-15T16:46:42Z

[Term]
id: GO:1902905
name: positive regulation of supramolecular fiber organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388]
comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro
synonym: "activation of fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of fibril organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie]
synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097435 ! supramolecular fiber organization
relationship: positively_regulates GO:0097435 ! supramolecular fiber organization
created_by: rl
creation_date: 2014-04-15T16:46:48Z

[Term]
id: GO:1902913
name: positive regulation of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506]
synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060563 ! neuroepithelial cell differentiation
relationship: positively_regulates GO:0060563 ! neuroepithelial cell differentiation
created_by: mr
creation_date: 2014-04-18T21:06:42Z

[Term]
id: GO:1903008
name: organelle disassembly
namespace: biological_process
def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]
synonym: "organelle degradation" EXACT []
is_a: GO:0006996 ! organelle organization
is_a: GO:0022411 ! cellular component disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0043226 ! organelle
relationship: results_in_disassembly_of GO:0043226 ! organelle
created_by: jl
creation_date: 2014-05-13T12:36:03Z

[Term]
id: GO:1903010
name: regulation of bone development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060348 ! bone development
relationship: regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:41:53Z

[Term]
id: GO:1903011
name: negative regulation of bone development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "down regulation of bone development" EXACT [GOC:TermGenie]
synonym: "down-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "downregulation of bone development" EXACT [GOC:TermGenie]
synonym: "inhibition of bone development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060348 ! bone development
relationship: negatively_regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:42:00Z

[Term]
id: GO:1903012
name: positive regulation of bone development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437]
synonym: "activation of bone development" NARROW [GOC:TermGenie]
synonym: "up regulation of bone development" EXACT [GOC:TermGenie]
synonym: "up-regulation of bone development" EXACT [GOC:TermGenie]
synonym: "upregulation of bone development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903010 ! regulation of bone development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060348 ! bone development
relationship: positively_regulates GO:0060348 ! bone development
created_by: mr
creation_date: 2014-05-13T22:42:06Z

[Term]
id: GO:1903018
name: regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009100 ! glycoprotein metabolic process
relationship: regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:19Z

[Term]
id: GO:1903019
name: negative regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009100 ! glycoprotein metabolic process
relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:25Z

[Term]
id: GO:1903020
name: positive regulation of glycoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079]
comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein
synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:1903018 ! regulation of glycoprotein metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009100 ! glycoprotein metabolic process
relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process
created_by: rl
creation_date: 2014-05-14T18:44:31Z

[Term]
id: GO:1903037
name: regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022407 ! regulation of cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:29:58Z

[Term]
id: GO:1903038
name: negative regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:30:05Z

[Term]
id: GO:1903039
name: positive regulation of leukocyte cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532]
comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion
synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie]
synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie]
synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie]
synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion
relationship: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion
created_by: rl
creation_date: 2014-05-19T15:30:15Z

[Term]
id: GO:1903045
name: neural crest cell migration involved in sympathetic nervous system development
namespace: biological_process
def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129]
comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development
is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0048485 ! sympathetic nervous system development
relationship: part_of GO:0048485 ! sympathetic nervous system development
created_by: rl
creation_date: 2014-05-22T07:06:02Z

[Term]
id: GO:1903046
name: meiotic cell cycle process
namespace: biological_process
def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
subset: goslim_pombe
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022414 ! reproductive process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0051321 ! meiotic cell cycle
disjoint_from: GO:1903047 ! mitotic cell cycle process
relationship: part_of GO:0051321 ! meiotic cell cycle
created_by: jl
creation_date: 2014-05-22T14:22:28Z

[Term]
id: GO:1903047
name: mitotic cell cycle process
namespace: biological_process
def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]
subset: gocheck_do_not_annotate
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0009987 ! cellular process
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle
created_by: jl
creation_date: 2014-05-22T14:22:34Z

[Term]
id: GO:1903053
name: regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030198 ! extracellular matrix organization
relationship: regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:41Z

[Term]
id: GO:1903054
name: negative regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030198 ! extracellular matrix organization
relationship: negatively_regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:47Z

[Term]
id: GO:1903055
name: positive regulation of extracellular matrix organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537]
synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie]
synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030198 ! extracellular matrix organization
relationship: positively_regulates GO:0030198 ! extracellular matrix organization
created_by: rl
creation_date: 2014-05-23T17:15:53Z

[Term]
id: GO:1903076
name: regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090003
alt_id: GO:1905963
def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein targeting to plasma membrane" RELATED []
synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072659 ! protein localization to plasma membrane
relationship: regulates GO:0072659 ! protein localization to plasma membrane
created_by: tb
creation_date: 2009-07-10T10:32:44Z

[Term]
id: GO:1903077
name: negative regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090005
alt_id: GO:1905964
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED []
synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie]
synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein targeting to plasma membrane" RELATED []
synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072659 ! protein localization to plasma membrane
relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane
created_by: tb
creation_date: 2014-05-29T17:10:16Z

[Term]
id: GO:1903078
name: positive regulation of protein localization to plasma membrane
namespace: biological_process
alt_id: GO:0090004
alt_id: GO:1905965
def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah]
synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED []
synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein targeting to plasma membrane" RELATED []
synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie]
synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie]
is_a: GO:1903076 ! regulation of protein localization to plasma membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072659 ! protein localization to plasma membrane
relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane
created_by: tb
creation_date: 2009-07-10T10:34:17Z

[Term]
id: GO:1903115
name: regulation of actin filament-based movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
is_a: GO:0032970 ! regulation of actin filament-based process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030048 ! actin filament-based movement
relationship: regulates GO:0030048 ! actin filament-based movement
created_by: al
creation_date: 2014-06-12T16:55:57Z

[Term]
id: GO:1903116
name: positive regulation of actin filament-based movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]
synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie]
synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie]
synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:1903115 ! regulation of actin filament-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030048 ! actin filament-based movement
relationship: positively_regulates GO:0030048 ! actin filament-based movement
created_by: al
creation_date: 2014-06-12T16:56:04Z

[Term]
id: GO:1903119
name: protein localization to actin cytoskeleton
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie]
synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie]
is_a: GO:0044380 ! protein localization to cytoskeleton
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0015629 ! actin cytoskeleton
relationship: has_target_end_location GO:0015629 ! actin cytoskeleton
created_by: mah
creation_date: 2014-06-16T11:27:09Z

[Term]
id: GO:1903120
name: protein localization to actin filament bundle
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735]
synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie]
synonym: "protein localization to actin cable" RELATED [GOC:mah]
is_a: GO:1903119 ! protein localization to actin cytoskeleton
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0032432 ! actin filament bundle
relationship: has_target_end_location GO:0032432 ! actin filament bundle
created_by: mah
creation_date: 2014-06-16T11:27:16Z

[Term]
id: GO:1903131
name: mononuclear cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906]
is_a: GO:0002521 ! leukocyte differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0000842 ! mononuclear cell
relationship: results_in_acquisition_of_features_of CL:0000842 ! mononuclear cell
created_by: cls
creation_date: 2014-06-25T15:47:09Z

[Term]
id: GO:1903224
name: regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035987 ! endodermal cell differentiation
relationship: regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:35Z

[Term]
id: GO:1903225
name: negative regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035987 ! endodermal cell differentiation
relationship: negatively_regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:41Z

[Term]
id: GO:1903226
name: positive regulation of endodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389]
synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1903224 ! regulation of endodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035987 ! endodermal cell differentiation
relationship: positively_regulates GO:0035987 ! endodermal cell differentiation
created_by: als
creation_date: 2014-07-29T13:22:47Z

[Term]
id: GO:1903292
name: protein localization to Golgi membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]
synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie]
is_a: GO:0034067 ! protein localization to Golgi apparatus
is_a: GO:0072657 ! protein localization to membrane
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0000139 ! Golgi membrane
relationship: has_target_end_location GO:0000139 ! Golgi membrane
created_by: mah
creation_date: 2014-08-12T14:22:31Z

[Term]
id: GO:1903335
name: regulation of vacuolar transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
is_a: GO:0032386 ! regulation of intracellular transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007034 ! vacuolar transport
relationship: regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:04Z

[Term]
id: GO:1903336
name: negative regulation of vacuolar transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007034 ! vacuolar transport
relationship: negatively_regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:11Z

[Term]
id: GO:1903337
name: positive regulation of vacuolar transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie]
synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:1903335 ! regulation of vacuolar transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007034 ! vacuolar transport
relationship: positively_regulates GO:0007034 ! vacuolar transport
created_by: vw
creation_date: 2014-08-18T13:16:19Z

[Term]
id: GO:1903353
name: regulation of nucleus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282]
synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie]
synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie]
synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006997 ! nucleus organization
relationship: regulates GO:0006997 ! nucleus organization
created_by: hjd
creation_date: 2014-08-20T19:36:16Z

[Term]
id: GO:1903358
name: regulation of Golgi organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]
synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie]
synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007030 ! Golgi organization
relationship: regulates GO:0007030 ! Golgi organization
created_by: als
creation_date: 2014-08-21T10:22:22Z

[Term]
id: GO:1903379
name: regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0060623 ! regulation of chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007076 ! mitotic chromosome condensation
relationship: regulates GO:0007076 ! mitotic chromosome condensation
created_by: al
creation_date: 2014-08-26T13:57:13Z

[Term]
id: GO:1903380
name: positive regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640]
synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
is_a: GO:1905821 ! positive regulation of chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007076 ! mitotic chromosome condensation
relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation
created_by: al
creation_date: 2014-08-26T13:57:29Z

[Term]
id: GO:1903412
name: response to bile acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002]
is_a: GO:0014070 ! response to organic cyclic compound
is_a: GO:0033993 ! response to lipid
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:3098 ! bile acid
relationship: has_primary_input CHEBI:3098 ! bile acid
created_by: rl
creation_date: 2014-09-03T12:45:43Z

[Term]
id: GO:1903429
name: regulation of cell maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048469 ! cell maturation
relationship: regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:23Z

[Term]
id: GO:1903430
name: negative regulation of cell maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie]
synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie]
synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048469 ! cell maturation
relationship: negatively_regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:32Z

[Term]
id: GO:1903431
name: positive regulation of cell maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944]
synonym: "activation of cell maturation" NARROW [GOC:TermGenie]
synonym: "activation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:1903429 ! regulation of cell maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048469 ! cell maturation
relationship: positively_regulates GO:0048469 ! cell maturation
created_by: jl
creation_date: 2014-09-15T13:31:41Z

[Term]
id: GO:1903441
name: protein localization to ciliary membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371]
synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:1990778 ! protein localization to cell periphery
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0060170 ! ciliary membrane
relationship: has_target_end_location GO:0060170 ! ciliary membrane
created_by: pr
creation_date: 2014-09-16T15:15:39Z

[Term]
id: GO:1903510
name: mucopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091]
synonym: "mucopolysaccharide metabolism" EXACT [GOC:TermGenie]
is_a: GO:0030203 ! glycosaminoglycan metabolic process
intersection_of: GO:0008152 ! metabolic process
intersection_of: has_primary_input_or_output CHEBI:37395 ! mucopolysaccharide
relationship: has_primary_input_or_output CHEBI:37395 ! mucopolysaccharide
created_by: dph
creation_date: 2014-10-01T21:55:47Z

[Term]
id: GO:1903522
name: regulation of blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008015 ! blood circulation
relationship: regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:38:56Z

[Term]
id: GO:1903523
name: negative regulation of blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008015 ! blood circulation
relationship: negatively_regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:39:05Z

[Term]
id: GO:1903524
name: positive regulation of blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]
synonym: "activation of blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie]
synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008015 ! blood circulation
relationship: positively_regulates GO:0008015 ! blood circulation
created_by: mr
creation_date: 2014-10-06T18:39:13Z

[Term]
id: GO:1903530
name: regulation of secretion by cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051046 ! regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032940 ! secretion by cell
relationship: regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:24:59Z

[Term]
id: GO:1903531
name: negative regulation of secretion by cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032940 ! secretion by cell
relationship: negatively_regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:25:08Z

[Term]
id: GO:1903532
name: positive regulation of secretion by cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530]
synonym: "activation of cellular secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion by cell" NARROW [GOC:TermGenie]
synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:1903530 ! regulation of secretion by cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032940 ! secretion by cell
relationship: positively_regulates GO:0032940 ! secretion by cell
created_by: pm
creation_date: 2014-10-08T13:25:17Z

[Term]
id: GO:1903537
name: meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "meiosis involved in oocyte maturation" BROAD []
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
is_a: GO:1903046 ! meiotic cell cycle process
intersection_of: GO:1903046 ! meiotic cell cycle process
intersection_of: part_of GO:0001556 ! oocyte maturation
relationship: part_of GO:0001556 ! oocyte maturation
created_by: pr
creation_date: 2014-10-09T10:46:14Z

[Term]
id: GO:1903538
name: regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395]
synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: pr
creation_date: 2014-10-09T10:52:38Z

[Term]
id: GO:1903541
name: regulation of exosomal secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0017157 ! regulation of exocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990182 ! exosomal secretion
relationship: regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:38:52Z

[Term]
id: GO:1903542
name: negative regulation of exosomal secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0045920 ! negative regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990182 ! exosomal secretion
relationship: negatively_regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:39:02Z

[Term]
id: GO:1903543
name: positive regulation of exosomal secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie]
synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie]
synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie]
synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie]
synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie]
synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0045921 ! positive regulation of exocytosis
is_a: GO:1903541 ! regulation of exosomal secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990182 ! exosomal secretion
relationship: positively_regulates GO:1990182 ! exosomal secretion
created_by: pga
creation_date: 2014-10-14T11:39:10Z

[Term]
id: GO:1903551
name: regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902115 ! regulation of organelle assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071971 ! extracellular exosome assembly
relationship: regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:25Z

[Term]
id: GO:1903552
name: negative regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles]
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071971 ! extracellular exosome assembly
relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:33Z

[Term]
id: GO:1903553
name: positive regulation of extracellular exosome assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262]
synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles]
synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie]
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1903551 ! regulation of extracellular exosome assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071971 ! extracellular exosome assembly
relationship: positively_regulates GO:0071971 ! extracellular exosome assembly
created_by: pga
creation_date: 2014-10-20T15:37:42Z

[Term]
id: GO:1903561
name: extracellular vesicle
namespace: cellular_component
def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]
synonym: "microparticle" RELATED [GOC:vesicles]
is_a: GO:0031982 ! vesicle
is_a: GO:0065010 ! extracellular membrane-bounded organelle
intersection_of: GO:0031982 ! vesicle
intersection_of: part_of GO:0005576 ! extracellular region
created_by: jl
creation_date: 2014-10-22T14:26:11Z

[Term]
id: GO:1903564
name: regulation of protein localization to cilium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061512 ! protein localization to cilium
relationship: regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:11Z

[Term]
id: GO:1903565
name: negative regulation of protein localization to cilium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903828 ! negative regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061512 ! protein localization to cilium
relationship: negatively_regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:20Z

[Term]
id: GO:1903566
name: positive regulation of protein localization to cilium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1903829 ! positive regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061512 ! protein localization to cilium
relationship: positively_regulates GO:0061512 ! protein localization to cilium
created_by: krc
creation_date: 2014-10-24T20:58:28Z

[Term]
id: GO:1903567
name: regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903564 ! regulation of protein localization to cilium
is_a: GO:1904375 ! regulation of protein localization to cell periphery
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1903441 ! protein localization to ciliary membrane
relationship: regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:32:51Z

[Term]
id: GO:1903568
name: negative regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903565 ! negative regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1905476 ! negative regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903441 ! protein localization to ciliary membrane
relationship: negatively_regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:32:59Z

[Term]
id: GO:1903569
name: positive regulation of protein localization to ciliary membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]
synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie]
is_a: GO:1903566 ! positive regulation of protein localization to cilium
is_a: GO:1903567 ! regulation of protein localization to ciliary membrane
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1905477 ! positive regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903441 ! protein localization to ciliary membrane
relationship: positively_regulates GO:1903441 ! protein localization to ciliary membrane
created_by: krc
creation_date: 2014-10-24T21:33:08Z

[Term]
id: GO:1903624
name: regulation of DNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006308 ! DNA catabolic process
relationship: regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:35Z

[Term]
id: GO:1903625
name: negative regulation of DNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie]
synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006308 ! DNA catabolic process
relationship: negatively_regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:43Z

[Term]
id: GO:1903626
name: positive regulation of DNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740]
synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie]
synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie]
synonym: "activation of DNA degradation" NARROW [GOC:TermGenie]
synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:1903624 ! regulation of DNA catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006308 ! DNA catabolic process
relationship: positively_regulates GO:0006308 ! DNA catabolic process
created_by: sl
creation_date: 2014-11-19T22:36:51Z

[Term]
id: GO:1903697
name: negative regulation of microvillus assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030033 ! microvillus assembly
relationship: negatively_regulates GO:0030033 ! microvillus assembly
created_by: als
creation_date: 2014-12-03T11:45:08Z

[Term]
id: GO:1903698
name: positive regulation of microvillus assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597]
synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie]
synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0032534 ! regulation of microvillus assembly
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030033 ! microvillus assembly
relationship: positively_regulates GO:0030033 ! microvillus assembly
created_by: als
creation_date: 2014-12-03T11:45:17Z

[Term]
id: GO:1903701
name: substantia propria of cornea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382]
synonym: "corneal stroma development" EXACT [GOC:TermGenie]
synonym: "stroma of cornea development" EXACT [GOC:TermGenie]
synonym: "substantia propria development" RELATED [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001777 ! substantia propria of cornea
relationship: results_in_development_of UBERON:0001777 ! substantia propria of cornea
created_by: cls
creation_date: 2014-12-03T13:12:09Z

[Term]
id: GO:1903702
name: esophagus development
namespace: biological_process
def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8]
synonym: "esophageal development" EXACT [MGI:csmith]
synonym: "gullet development" EXACT [GOC:TermGenie]
synonym: "oesophagus development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001043 ! esophagus
relationship: results_in_development_of UBERON:0001043 ! esophagus
created_by: cls
creation_date: 2014-12-03T14:41:30Z

[Term]
id: GO:1903706
name: regulation of hemopoiesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030097 ! hemopoiesis
relationship: regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:13Z

[Term]
id: GO:1903707
name: negative regulation of hemopoiesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie]
synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030097 ! hemopoiesis
relationship: negatively_regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:21Z

[Term]
id: GO:1903708
name: positive regulation of hemopoiesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]
comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype.
synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of blood cell formation" NARROW [GOC:TermGenie]
synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie]
synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie]
synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie]
synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1903706 ! regulation of hemopoiesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030097 ! hemopoiesis
relationship: positively_regulates GO:0030097 ! hemopoiesis
created_by: pad
creation_date: 2014-12-04T15:34:30Z

[Term]
id: GO:1903709
name: uterine gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340]
synonym: "endometrial gland development" EXACT [GOC:TermGenie]
synonym: "endometrium gland development" EXACT [GOC:TermGenie]
synonym: "glandulae uterinae development" RELATED [GOC:TermGenie]
synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie]
synonym: "set of uterine glands development" RELATED [GOC:TermGenie]
synonym: "uterine glands development" EXACT [GOC:TermGenie]
synonym: "uterine glands set development" EXACT [GOC:TermGenie]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002451 ! endometrial gland
relationship: results_in_development_of UBERON:0002451 ! endometrial gland
created_by: cls
creation_date: 2014-12-04T18:57:21Z

[Term]
id: GO:1903729
name: regulation of plasma membrane organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]
synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie]
synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007009 ! plasma membrane organization
relationship: regulates GO:0007009 ! plasma membrane organization
created_by: al
creation_date: 2014-12-10T18:59:44Z

[Term]
id: GO:1903778
name: protein localization to vacuolar membrane
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562]
synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie]
synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie]
is_a: GO:0072657 ! protein localization to membrane
is_a: GO:0072665 ! protein localization to vacuole
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005774 ! vacuolar membrane
relationship: has_target_end_location GO:0005774 ! vacuolar membrane
created_by: mah
creation_date: 2015-01-07T13:15:54Z

[Term]
id: GO:1903779
name: regulation of cardiac conduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061337 ! cardiac conduction
relationship: regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:11Z

[Term]
id: GO:1903780
name: negative regulation of cardiac conduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061337 ! cardiac conduction
relationship: negatively_regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:20Z

[Term]
id: GO:1903781
name: positive regulation of cardiac conduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627]
synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1903779 ! regulation of cardiac conduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061337 ! cardiac conduction
relationship: positively_regulates GO:0061337 ! cardiac conduction
created_by: rph
creation_date: 2015-01-07T13:20:28Z

[Term]
id: GO:1903789
name: regulation of amino acid transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814]
synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003333 ! amino acid transmembrane transport
relationship: regulates GO:0003333 ! amino acid transmembrane transport
created_by: al
creation_date: 2015-01-08T17:42:18Z

[Term]
id: GO:1903795
name: regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034762 ! regulation of transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:44:49Z

[Term]
id: GO:1903796
name: negative regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:44:59Z

[Term]
id: GO:1903797
name: positive regulation of inorganic anion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802]
synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie]
synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie]
synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie]
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098661 ! inorganic anion transmembrane transport
relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport
created_by: sl
creation_date: 2015-01-14T21:45:08Z

[Term]
id: GO:1903825
name: organic acid transmembrane transport
namespace: biological_process
def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie]
is_a: GO:0015849 ! organic acid transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:64709 ! organic acid
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: vw
creation_date: 2015-01-20T10:20:58Z

[Term]
id: GO:1903828
name: negative regulation of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of cellular protein localization" EXACT []
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008104 ! protein localization
relationship: negatively_regulates GO:0008104 ! protein localization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI
created_by: jl
creation_date: 2015-01-20T14:32:24Z

[Term]
id: GO:1903829
name: positive regulation of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]
synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of cellular protein localization" EXACT []
synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008104 ! protein localization
relationship: positively_regulates GO:0008104 ! protein localization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22021" xsd:anyURI
created_by: jl
creation_date: 2015-01-20T14:32:33Z

[Term]
id: GO:1903847
name: regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
is_a: GO:1905651 ! regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035909 ! aorta morphogenesis
relationship: regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:00:51Z

[Term]
id: GO:1903848
name: negative regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905652 ! negative regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035909 ! aorta morphogenesis
relationship: negatively_regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:01:01Z

[Term]
id: GO:1903849
name: positive regulation of aorta morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326]
synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:1903847 ! regulation of aorta morphogenesis
is_a: GO:1905653 ! positive regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035909 ! aorta morphogenesis
relationship: positively_regulates GO:0035909 ! aorta morphogenesis
created_by: rph
creation_date: 2015-01-23T14:01:09Z

[Term]
id: GO:1903867
name: extraembryonic membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0005631 ! extraembryonic membrane
relationship: results_in_development_of UBERON:0005631 ! extraembryonic membrane
created_by: cjm
creation_date: 2015-02-05T00:42:16Z

[Term]
id: GO:1903903
name: regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001768 ! establishment of T cell polarity
relationship: regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:21Z

[Term]
id: GO:1903904
name: negative regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050868 ! negative regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001768 ! establishment of T cell polarity
relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:30Z

[Term]
id: GO:1903905
name: positive regulation of establishment of T cell polarity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248]
synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie]
synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie]
synonym: "activation of T cell polarization" NARROW [GOC:TermGenie]
synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie]
synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie]
synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie]
synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie]
is_a: GO:0050870 ! positive regulation of T cell activation
is_a: GO:1903903 ! regulation of establishment of T cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001768 ! establishment of T cell polarity
relationship: positively_regulates GO:0001768 ! establishment of T cell polarity
created_by: als
creation_date: 2015-02-09T10:50:40Z

[Term]
id: GO:1903941
name: negative regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system
created_by: sl
creation_date: 2015-02-17T20:26:24Z

[Term]
id: GO:1903942
name: positive regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705]
synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie]
synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system
created_by: sl
creation_date: 2015-02-17T20:26:35Z

[Term]
id: GO:1903943
name: regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097284 ! hepatocyte apoptotic process
relationship: regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:40Z

[Term]
id: GO:1903944
name: negative regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097284 ! hepatocyte apoptotic process
relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:50Z

[Term]
id: GO:1903945
name: positive regulation of hepatocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852]
synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1903943 ! regulation of hepatocyte apoptotic process
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097284 ! hepatocyte apoptotic process
relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process
created_by: sl
creation_date: 2015-02-19T12:54:59Z

[Term]
id: GO:1903950
name: negative regulation of AV node cell action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0086016 ! AV node cell action potential
relationship: negatively_regulates GO:0086016 ! AV node cell action potential
created_by: nc
creation_date: 2015-02-20T14:59:41Z

[Term]
id: GO:1903951
name: positive regulation of AV node cell action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747]
synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie]
synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0098904 ! regulation of AV node cell action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0086016 ! AV node cell action potential
relationship: positively_regulates GO:0086016 ! AV node cell action potential
created_by: nc
creation_date: 2015-02-20T14:59:50Z

[Term]
id: GO:1903975
name: regulation of glial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008347 ! glial cell migration
relationship: regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:31Z

[Term]
id: GO:1903976
name: negative regulation of glial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008347 ! glial cell migration
relationship: negatively_regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:38Z

[Term]
id: GO:1903977
name: positive regulation of glial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238]
synonym: "activation of glia cell migration" NARROW [GOC:TermGenie]
synonym: "activation of glial cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1903975 ! regulation of glial cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008347 ! glial cell migration
relationship: positively_regulates GO:0008347 ! glial cell migration
created_by: nc
creation_date: 2015-03-02T15:13:43Z

[Term]
id: GO:1904014
name: response to serotonin
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525]
is_a: GO:1901698 ! response to nitrogen compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:350546 ! serotonin(1+)
relationship: has_primary_input CHEBI:350546 ! serotonin(1+)
created_by: sl
creation_date: 2015-03-06T19:33:54Z

[Term]
id: GO:1904018
name: positive regulation of vasculature development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453]
synonym: "activation of vascular system development" RELATED [GOC:TermGenie]
synonym: "activation of vasculature development" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie]
synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901342 ! regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001944 ! vasculature development
relationship: positively_regulates GO:0001944 ! vasculature development
created_by: sl
creation_date: 2015-03-06T22:17:04Z

[Term]
id: GO:1904019
name: epithelial cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015]
synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000066 ! epithelial cell
relationship: occurs_in CL:0000066 ! epithelial cell
property_value: RO:0002161 NCBITaxon:33090
property_value: RO:0002161 NCBITaxon_Union:0000023
created_by: sl
creation_date: 2015-03-06T22:27:17Z

[Term]
id: GO:1904026
name: regulation of collagen fibril organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "regulation of collagen fibrillogenesis" RELATED []
synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902903 ! regulation of supramolecular fiber organization
is_a: GO:1903053 ! regulation of extracellular matrix organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030199 ! collagen fibril organization
relationship: regulates GO:0030199 ! collagen fibril organization
created_by: ae
creation_date: 2015-03-12T12:36:52Z

[Term]
id: GO:1904027
name: negative regulation of collagen fibril organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1903054 ! negative regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030199 ! collagen fibril organization
relationship: negatively_regulates GO:0030199 ! collagen fibril organization
created_by: ae
creation_date: 2015-03-12T12:36:59Z

[Term]
id: GO:1904028
name: positive regulation of collagen fibril organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920]
synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie]
synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie]
synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie]
synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie]
synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie]
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1903055 ! positive regulation of extracellular matrix organization
is_a: GO:1904026 ! regulation of collagen fibril organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030199 ! collagen fibril organization
relationship: positively_regulates GO:0030199 ! collagen fibril organization
created_by: ae
creation_date: 2015-03-12T12:37:06Z

[Term]
id: GO:1904035
name: regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904019 ! epithelial cell apoptotic process
relationship: regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:41Z

[Term]
id: GO:1904036
name: negative regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904019 ! epithelial cell apoptotic process
relationship: negatively_regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:47Z

[Term]
id: GO:1904037
name: positive regulation of epithelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015]
synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904019 ! epithelial cell apoptotic process
relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic process
created_by: sl
creation_date: 2015-03-13T22:05:53Z

[Term]
id: GO:1904054
name: regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990705 ! cholangiocyte proliferation
relationship: regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:14Z

[Term]
id: GO:1904055
name: negative regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990705 ! cholangiocyte proliferation
relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:20Z

[Term]
id: GO:1904056
name: positive regulation of cholangiocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010]
synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie]
synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904054 ! regulation of cholangiocyte proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990705 ! cholangiocyte proliferation
relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation
created_by: sl
creation_date: 2015-03-18T17:56:26Z

[Term]
id: GO:1904057
name: negative regulation of sensory perception of pain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "down regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "down-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "downregulation of nociception" EXACT [GOC:TermGenie]
synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "inhibition of nociception" NARROW [GOC:TermGenie]
synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "negative regulation of nociception" EXACT [GOC:TermGenie]
synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie]
is_a: GO:0031645 ! negative regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019233 ! sensory perception of pain
relationship: negatively_regulates GO:0019233 ! sensory perception of pain
created_by: sl
creation_date: 2015-03-18T20:33:57Z

[Term]
id: GO:1904058
name: positive regulation of sensory perception of pain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]
synonym: "activation of nociception" NARROW [GOC:TermGenie]
synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie]
synonym: "positive regulation of nociception" EXACT [GOC:TermGenie]
synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "up-regulation of nociception" EXACT [GOC:TermGenie]
synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie]
synonym: "upregulation of nociception" EXACT [GOC:TermGenie]
synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie]
synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie]
is_a: GO:0031646 ! positive regulation of nervous system process
is_a: GO:0051930 ! regulation of sensory perception of pain
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019233 ! sensory perception of pain
relationship: positively_regulates GO:0019233 ! sensory perception of pain
created_by: sl
creation_date: 2015-03-18T20:34:03Z

[Term]
id: GO:1904062
name: regulation of monoatomic cation transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "regulation of cation transmembrane transport" BROAD []
is_a: GO:0034765 ! regulation of monoatomic ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098655 ! monoatomic cation transmembrane transport
relationship: regulates GO:0098655 ! monoatomic cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:43Z

[Term]
id: GO:1904063
name: negative regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie]
is_a: GO:0034766 ! negative regulation of monoatomic ion transmembrane transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098655 ! monoatomic cation transmembrane transport
relationship: negatively_regulates GO:0098655 ! monoatomic cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:50Z

[Term]
id: GO:1904064
name: positive regulation of cation transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]
synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie]
synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie]
synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie]
is_a: GO:0034767 ! positive regulation of monoatomic ion transmembrane transport
is_a: GO:1904062 ! regulation of monoatomic cation transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098655 ! monoatomic cation transmembrane transport
relationship: positively_regulates GO:0098655 ! monoatomic cation transmembrane transport
created_by: sl
creation_date: 2015-03-18T21:11:55Z

[Term]
id: GO:1904073
name: regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0048638 ! regulation of developmental growth
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001834 ! trophectodermal cell proliferation
relationship: regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:55:56Z

[Term]
id: GO:1904074
name: negative regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001834 ! trophectodermal cell proliferation
relationship: negatively_regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:56:02Z

[Term]
id: GO:1904075
name: positive regulation of trophectodermal cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636]
synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:1904073 ! regulation of trophectodermal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001834 ! trophectodermal cell proliferation
relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferation
created_by: tb
creation_date: 2015-03-20T16:56:08Z

[Term]
id: GO:1904106
name: protein localization to microvillus
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]
synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie]
synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie]
synonym: "protein localization in microvillus" EXACT [GOC:TermGenie]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005902 ! microvillus
relationship: has_target_end_location GO:0005902 ! microvillus
created_by: kmv
creation_date: 2015-04-01T18:14:41Z

[Term]
id: GO:1904145
name: negative regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051447 ! negative regulation of meiotic cell cycle
is_a: GO:1900194 ! negative regulation of oocyte maturation
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: tb
creation_date: 2015-04-14T15:59:22Z

[Term]
id: GO:1904146
name: positive regulation of meiotic cell cycle process involved in oocyte maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394]
synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie]
synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie]
is_a: GO:0051446 ! positive regulation of meiotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation
created_by: tb
creation_date: 2015-04-14T15:59:28Z

[Term]
id: GO:1904170
name: regulation of bleb assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032060 ! bleb assembly
relationship: regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:19Z

[Term]
id: GO:1904171
name: negative regulation of bleb assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0032060 ! bleb assembly
relationship: negatively_regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:25Z

[Term]
id: GO:1904172
name: positive regulation of bleb assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887]
synonym: "activation of bleb assembly" NARROW [GOC:TermGenie]
synonym: "activation of cell blebbing" NARROW [GOC:TermGenie]
synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie]
synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:1904170 ! regulation of bleb assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0032060 ! bleb assembly
relationship: positively_regulates GO:0032060 ! bleb assembly
created_by: als
creation_date: 2015-04-23T09:32:31Z

[Term]
id: GO:1904177
name: regulation of adipose tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060612 ! adipose tissue development
relationship: regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:01Z

[Term]
id: GO:1904178
name: negative regulation of adipose tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060612 ! adipose tissue development
relationship: negatively_regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:07Z

[Term]
id: GO:1904179
name: positive regulation of adipose tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
synonym: "activation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904177 ! regulation of adipose tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060612 ! adipose tissue development
relationship: positively_regulates GO:0060612 ! adipose tissue development
created_by: sl
creation_date: 2015-04-29T20:01:13Z

[Term]
id: GO:1904192
name: regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:25:48Z

[Term]
id: GO:1904193
name: negative regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:25:55Z

[Term]
id: GO:1904194
name: positive regulation of cholangiocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161]
synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902488 ! cholangiocyte apoptotic process
relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process
created_by: sl
creation_date: 2015-05-06T15:26:00Z

[Term]
id: GO:1904204
name: regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
is_a: GO:0014733 ! regulation of skeletal muscle adaptation
is_a: GO:0014743 ! regulation of muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:13Z

[Term]
id: GO:1904205
name: negative regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:19Z

[Term]
id: GO:1904206
name: positive regulation of skeletal muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307]
synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014734 ! skeletal muscle hypertrophy
relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy
created_by: sl
creation_date: 2015-05-08T17:38:25Z

[Term]
id: GO:1904251
name: regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008206 ! bile acid metabolic process
relationship: regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:28Z

[Term]
id: GO:1904252
name: negative regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008206 ! bile acid metabolic process
relationship: negatively_regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:35Z

[Term]
id: GO:1904253
name: positive regulation of bile acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie]
synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie]
synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie]
synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie]
synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:1904251 ! regulation of bile acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008206 ! bile acid metabolic process
relationship: positively_regulates GO:0008206 ! bile acid metabolic process
created_by: bf
creation_date: 2015-05-20T11:04:40Z

[Term]
id: GO:1904269
name: cell leading edge cell cortex
namespace: cellular_component
def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030]
synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie]
synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie]
synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie]
synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie]
synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie]
synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie]
synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie]
is_a: GO:0099738 ! cell cortex region
intersection_of: GO:0099738 ! cell cortex region
intersection_of: part_of GO:0031252 ! cell leading edge
relationship: part_of GO:0031252 ! cell leading edge
created_by: kmv
creation_date: 2015-05-28T19:16:03Z

[Term]
id: GO:1904304
name: regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
is_a: GO:0006940 ! regulation of smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:42Z

[Term]
id: GO:1904305
name: negative regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:48Z

[Term]
id: GO:1904306
name: positive regulation of gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044]
synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
relationship: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction
created_by: sl
creation_date: 2015-06-09T23:18:54Z

[Term]
id: GO:1904318
name: regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044062 ! regulation of excretion
is_a: GO:0098801 ! regulation of renal system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:11Z

[Term]
id: GO:1904319
name: negative regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:17Z

[Term]
id: GO:1904320
name: positive regulation of smooth muscle contraction involved in micturition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635]
synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie]
synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie]
synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
relationship: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition
created_by: sl
creation_date: 2015-06-10T18:46:23Z

[Term]
id: GO:1904341
name: regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990765 ! colon smooth muscle contraction
relationship: regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:16:58Z

[Term]
id: GO:1904342
name: negative regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990765 ! colon smooth muscle contraction
relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:17:05Z

[Term]
id: GO:1904343
name: positive regulation of colon smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253]
synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904341 ! regulation of colon smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990765 ! colon smooth muscle contraction
relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:17:11Z

[Term]
id: GO:1904344
name: regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903522 ! regulation of blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990768 ! gastric mucosal blood circulation
relationship: regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:31Z

[Term]
id: GO:1904345
name: negative regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903523 ! negative regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990768 ! gastric mucosal blood circulation
relationship: negatively_regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:44Z

[Term]
id: GO:1904346
name: positive regulation of gastric mucosal blood circulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413]
synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie]
synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie]
synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie]
is_a: GO:1903524 ! positive regulation of blood circulation
is_a: GO:1904344 ! regulation of gastric mucosal blood circulation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990768 ! gastric mucosal blood circulation
relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulation
created_by: sl
creation_date: 2015-06-11T21:20:50Z

[Term]
id: GO:1904347
name: regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:34Z

[Term]
id: GO:1904348
name: negative regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:40Z

[Term]
id: GO:1904349
name: positive regulation of small intestine smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626]
synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie]
synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie]
is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction
is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990770 ! small intestine smooth muscle contraction
relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T21:37:46Z

[Term]
id: GO:1904350
name: regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042176 ! regulation of protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:36Z

[Term]
id: GO:1904351
name: negative regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:42Z

[Term]
id: GO:1904352
name: positive regulation of protein catabolic process in the vacuole
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054]
synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie]
synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie]
synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie]
synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie]
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007039 ! protein catabolic process in the vacuole
relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole
created_by: rl
creation_date: 2015-06-12T09:10:49Z

[Term]
id: GO:1904375
name: regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990778 ! protein localization to cell periphery
relationship: regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:25Z

[Term]
id: GO:1904376
name: negative regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990778 ! protein localization to cell periphery
relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:32Z

[Term]
id: GO:1904377
name: positive regulation of protein localization to cell periphery
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]
synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie]
synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990778 ! protein localization to cell periphery
relationship: positively_regulates GO:1990778 ! protein localization to cell periphery
created_by: sl
creation_date: 2015-06-22T22:09:37Z

[Term]
id: GO:1904396
name: regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007528 ! neuromuscular junction development
relationship: regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:42Z

[Term]
id: GO:1904397
name: negative regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:1904396 ! regulation of neuromuscular junction development
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007528 ! neuromuscular junction development
relationship: negatively_regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:48Z

[Term]
id: GO:1904398
name: positive regulation of neuromuscular junction development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643]
synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie]
synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "activation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie]
synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie]
synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1904396 ! regulation of neuromuscular junction development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007528 ! neuromuscular junction development
relationship: positively_regulates GO:0007528 ! neuromuscular junction development
created_by: sl
creation_date: 2015-06-23T19:23:54Z

[Term]
id: GO:1904409
name: regulation of secretory granule organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0033043 ! regulation of organelle organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033363 ! secretory granule organization
relationship: regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:42Z

[Term]
id: GO:1904410
name: negative regulation of secretory granule organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033363 ! secretory granule organization
relationship: negatively_regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:49Z

[Term]
id: GO:1904411
name: positive regulation of secretory granule organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777]
synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie]
synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie]
synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:1904409 ! regulation of secretory granule organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033363 ! secretory granule organization
relationship: positively_regulates GO:0033363 ! secretory granule organization
created_by: sl
creation_date: 2015-06-25T19:40:55Z

[Term]
id: GO:1904412
name: regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003231 ! cardiac ventricle development
relationship: regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:15Z

[Term]
id: GO:1904413
name: negative regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003231 ! cardiac ventricle development
relationship: negatively_regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:21Z

[Term]
id: GO:1904414
name: positive regulation of cardiac ventricle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510]
synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1904412 ! regulation of cardiac ventricle development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003231 ! cardiac ventricle development
relationship: positively_regulates GO:0003231 ! cardiac ventricle development
created_by: sl
creation_date: 2015-06-25T19:52:27Z

[Term]
id: GO:1904456
name: negative regulation of neuronal action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie]
synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie]
is_a: GO:0045759 ! negative regulation of action potential
is_a: GO:0051970 ! negative regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019228 ! neuronal action potential
relationship: negatively_regulates GO:0019228 ! neuronal action potential
created_by: sl
creation_date: 2015-07-09T18:02:40Z

[Term]
id: GO:1904457
name: positive regulation of neuronal action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]
synonym: "activation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie]
synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie]
synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie]
synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie]
is_a: GO:0045760 ! positive regulation of action potential
is_a: GO:0051971 ! positive regulation of transmission of nerve impulse
is_a: GO:0098908 ! regulation of neuronal action potential
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019228 ! neuronal action potential
relationship: positively_regulates GO:0019228 ! neuronal action potential
created_by: sl
creation_date: 2015-07-09T18:02:46Z

[Term]
id: GO:1904484
name: cloacal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421]
is_a: GO:0048732 ! gland development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0012478 ! cloacal gland
relationship: results_in_development_of UBERON:0012478 ! cloacal gland
created_by: mr
creation_date: 2015-07-15T22:14:39Z

[Term]
id: GO:1904491
name: protein localization to ciliary transition zone
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]
synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie]
synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie]
is_a: GO:0061512 ! protein localization to cilium
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0035869 ! ciliary transition zone
relationship: has_target_end_location GO:0035869 ! ciliary transition zone
created_by: kmv
creation_date: 2015-07-17T20:43:21Z

[Term]
id: GO:1904587
name: response to glycoprotein
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422]
synonym: "response to glycoproteins" EXACT []
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:17089 ! glycoprotein
relationship: has_primary_input CHEBI:17089 ! glycoprotein
created_by: sl
creation_date: 2015-08-20T16:46:24Z

[Term]
id: GO:1904606
name: fat cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416]
synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000136 ! adipocyte
relationship: occurs_in CL:0000136 ! adipocyte
created_by: sl
creation_date: 2015-08-27T18:13:06Z

[Term]
id: GO:1904649
name: regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904606 ! fat cell apoptotic process
relationship: regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:28Z

[Term]
id: GO:1904650
name: negative regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904606 ! fat cell apoptotic process
relationship: negatively_regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:34Z

[Term]
id: GO:1904651
name: positive regulation of fat cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416]
synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:1904649 ! regulation of fat cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904606 ! fat cell apoptotic process
relationship: positively_regulates GO:1904606 ! fat cell apoptotic process
created_by: sl
creation_date: 2015-08-31T20:59:40Z

[Term]
id: GO:1904659
name: glucose transmembrane transport
namespace: biological_process
alt_id: GO:0015758
def: "The process in which glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050]
synonym: "glucose transport" RELATED []
is_a: GO:0008645 ! hexose transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:17234 ! glucose
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:17234 ! glucose
created_by: vw
creation_date: 2015-09-04T17:20:16Z

[Term]
id: GO:1904671
name: negative regulation of cell differentiation involved in stem cell population maintenance
namespace: biological_process
def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
intersection_of: GO:0045596 ! negative regulation of cell differentiation
intersection_of: part_of GO:0019827 ! stem cell population maintenance
relationship: part_of GO:0019827 ! stem cell population maintenance
created_by: tb
creation_date: 2015-09-12T00:46:08Z

[Term]
id: GO:1904672
name: regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
is_a: GO:2000036 ! regulation of stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035019 ! somatic stem cell population maintenance
relationship: regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:19Z

[Term]
id: GO:1904673
name: negative regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
is_a: GO:1902455 ! negative regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035019 ! somatic stem cell population maintenance
relationship: negatively_regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:25Z

[Term]
id: GO:1904674
name: positive regulation of somatic stem cell population maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie]
synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie]
is_a: GO:1902459 ! positive regulation of stem cell population maintenance
is_a: GO:1904672 ! regulation of somatic stem cell population maintenance
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035019 ! somatic stem cell population maintenance
relationship: positively_regulates GO:0035019 ! somatic stem cell population maintenance
created_by: rph
creation_date: 2015-09-14T08:40:32Z

[Term]
id: GO:1904675
name: regulation of somatic stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:2000035 ! regulation of stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048103 ! somatic stem cell division
relationship: regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:22Z

[Term]
id: GO:1904676
name: negative regulation of somatic stem cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051782 ! negative regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048103 ! somatic stem cell division
relationship: negatively_regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:28Z

[Term]
id: GO:1904677
name: positive regulation of somatic stem cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607]
synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie]
synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie]
synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie]
synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie]
is_a: GO:0051781 ! positive regulation of cell division
is_a: GO:1904675 ! regulation of somatic stem cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048103 ! somatic stem cell division
relationship: positively_regulates GO:0048103 ! somatic stem cell division
created_by: rph
creation_date: 2015-09-14T08:47:34Z

[Term]
id: GO:1904680
name: peptide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015197
alt_id: GO:0015637
def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]
synonym: "peptide transporter activity" RELATED []
synonym: "peptide uptake permease activity" RELATED []
xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium"
is_a: GO:0042887 ! amide transmembrane transporter activity
intersection_of: GO:0005215 ! transporter activity
intersection_of: has_primary_input CHEBI:16670 ! peptide
intersection_of: results_in_transport_across GO:0016020 ! membrane
relationship: has_primary_input CHEBI:16670 ! peptide
created_by: tb
creation_date: 2015-09-22T18:50:41Z

[Term]
id: GO:1904691
name: negative regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: sl
creation_date: 2015-09-25T15:23:38Z

[Term]
id: GO:1904692
name: positive regulation of type B pancreatic cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447]
synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044342 ! type B pancreatic cell proliferation
relationship: positively_regulates GO:0044342 ! type B pancreatic cell proliferation
created_by: sl
creation_date: 2015-09-25T15:23:44Z

[Term]
id: GO:1904693
name: midbrain morphogenesis
namespace: biological_process
def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250]
synonym: "MB morphogenesis" BROAD [GOC:TermGenie]
synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0001891 ! midbrain
relationship: part_of GO:0030901 ! midbrain development
relationship: part_of GO:0048854 ! brain morphogenesis
relationship: results_in_morphogenesis_of UBERON:0001891 ! midbrain
created_by: bf
creation_date: 2015-09-29T09:15:28Z

[Term]
id: GO:1904697
name: regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990863 ! acinar cell proliferation
relationship: regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:19:50Z

[Term]
id: GO:1904698
name: negative regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990863 ! acinar cell proliferation
relationship: negatively_regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:19:57Z

[Term]
id: GO:1904699
name: positive regulation of acinar cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538]
synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:1904697 ! regulation of acinar cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990863 ! acinar cell proliferation
relationship: positively_regulates GO:1990863 ! acinar cell proliferation
created_by: sl
creation_date: 2015-09-30T15:20:03Z

[Term]
id: GO:1904705
name: regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
relationship: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:20Z

[Term]
id: GO:1904706
name: negative regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
relationship: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:26Z

[Term]
id: GO:1904707
name: positive regulation of vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT []
synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie]
is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation
is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
relationship: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation
created_by: sl
creation_date: 2015-10-01T16:05:32Z

[Term]
id: GO:1904738
name: vascular associated smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "vascular smooth muscle cell migration" EXACT []
is_a: GO:0014909 ! smooth muscle cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000359 ! vascular associated smooth muscle cell
relationship: results_in_movement_of CL:0000359 ! vascular associated smooth muscle cell
created_by: rph
creation_date: 2015-10-15T09:56:00Z

[Term]
id: GO:1904746
name: negative regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902742 ! apoptotic process involved in development
relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T14:12:27Z

[Term]
id: GO:1904747
name: positive regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: U4PR86 in PMID:22801495 inferred from mutant phenotype
synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1904748 ! regulation of apoptotic process involved in development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902742 ! apoptotic process involved in development
relationship: positively_regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T14:12:34Z

[Term]
id: GO:1904748
name: regulation of apoptotic process involved in development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495]
comment: Q10943 in PMID:22801495, inferred from mutant phenotype
synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie]
synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie]
synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie]
synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie]
is_a: GO:0042981 ! regulation of apoptotic process
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902742 ! apoptotic process involved in development
relationship: regulates GO:1902742 ! apoptotic process involved in development
created_by: es
creation_date: 2015-10-19T15:02:28Z

[Term]
id: GO:1904749
name: regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900180 ! regulation of protein localization to nucleus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902570 ! protein localization to nucleolus
relationship: regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:17Z

[Term]
id: GO:1904750
name: negative regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900181 ! negative regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902570 ! protein localization to nucleolus
relationship: negatively_regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:24Z

[Term]
id: GO:1904751
name: positive regulation of protein localization to nucleolus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760]
synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie]
is_a: GO:1900182 ! positive regulation of protein localization to nucleus
is_a: GO:1904749 ! regulation of protein localization to nucleolus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902570 ! protein localization to nucleolus
relationship: positively_regulates GO:1902570 ! protein localization to nucleolus
created_by: nc
creation_date: 2015-10-19T15:16:30Z

[Term]
id: GO:1904752
name: regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:49:52Z

[Term]
id: GO:1904753
name: negative regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:49:58Z

[Term]
id: GO:1904754
name: positive regulation of vascular associated smooth muscle cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317]
synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
relationship: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration
created_by: rph
creation_date: 2015-10-19T15:50:05Z

[Term]
id: GO:1904770
name: intramembranous bone morphogenesis
namespace: biological_process
def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686]
synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie]
synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie]
is_a: GO:0060349 ! bone morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002514 ! intramembranous bone
relationship: results_in_morphogenesis_of UBERON:0002514 ! intramembranous bone
created_by: dos
creation_date: 2015-10-28T11:46:04Z

[Term]
id: GO:1904776
name: regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904375 ! regulation of protein localization to cell periphery
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072697 ! protein localization to cell cortex
relationship: regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:01Z

[Term]
id: GO:1904777
name: negative regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904376 ! negative regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072697 ! protein localization to cell cortex
relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:08Z

[Term]
id: GO:1904778
name: positive regulation of protein localization to cell cortex
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027]
comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027.
synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie]
is_a: GO:1904377 ! positive regulation of protein localization to cell periphery
is_a: GO:1904776 ! regulation of protein localization to cell cortex
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072697 ! protein localization to cell cortex
relationship: positively_regulates GO:0072697 ! protein localization to cell cortex
created_by: es
creation_date: 2015-10-29T16:55:15Z

[Term]
id: GO:1904817
name: serous membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "serosa development" RELATED [GOC:TermGenie]
synonym: "tunica serosa development" EXACT [GOC:TermGenie]
synonym: "wall of serous sac development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0000042 ! serous membrane
relationship: results_in_development_of UBERON:0000042 ! serous membrane
created_by: dph
creation_date: 2015-11-17T19:00:01Z

[Term]
id: GO:1904818
name: visceral peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001178 ! visceral peritoneum
relationship: part_of GO:1904820 ! peritoneum development
relationship: results_in_development_of UBERON:0001178 ! visceral peritoneum
created_by: dph
creation_date: 2015-11-17T19:00:17Z

[Term]
id: GO:1904819
name: parietal peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001366 ! parietal peritoneum
relationship: part_of GO:1904820 ! peritoneum development
relationship: results_in_development_of UBERON:0001366 ! parietal peritoneum
created_by: dph
creation_date: 2015-11-17T19:00:24Z

[Term]
id: GO:1904820
name: peritoneum development
namespace: biological_process
def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053]
synonym: "peritonaeum development" RELATED [GOC:TermGenie]
is_a: GO:1904817 ! serous membrane development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0002358 ! peritoneum
relationship: results_in_development_of UBERON:0002358 ! peritoneum
created_by: dph
creation_date: 2015-11-18T17:23:51Z

[Term]
id: GO:1904829
name: regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:40Z

[Term]
id: GO:1904830
name: negative regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:47Z

[Term]
id: GO:1904831
name: positive regulation of aortic smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194]
synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation
is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation
created_by: rph
creation_date: 2015-11-24T10:20:54Z

[Term]
id: GO:1904888
name: cranial skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227]
synonym: "cranial skeleton development" NARROW [GOC:TermGenie]
synonym: "craniofacial development" NARROW [PMID:11262227]
synonym: "cranium development" RELATED [GOC:TermGenie]
synonym: "osteocranium development" NARROW [GOC:TermGenie]
is_a: GO:0048856 ! anatomical structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0010323 ! cranial skeletal system
relationship: results_in_development_of UBERON:0010323 ! cranial skeletal system
created_by: bf
creation_date: 2016-01-07T13:45:06Z

[Term]
id: GO:1904933
name: regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0033278 ! cell proliferation in midbrain
relationship: regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:11Z

[Term]
id: GO:1904934
name: negative regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302]
synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0033278 ! cell proliferation in midbrain
relationship: negatively_regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:19Z

[Term]
id: GO:1904935
name: positive regulation of cell proliferation in midbrain
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302]
synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie]
synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie]
synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie]
synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie]
synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie]
is_a: GO:1904933 ! regulation of cell proliferation in midbrain
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0033278 ! cell proliferation in midbrain
relationship: positively_regulates GO:0033278 ! cell proliferation in midbrain
created_by: bf
creation_date: 2016-02-01T13:16:27Z

[Term]
id: GO:1904936
name: interneuron migration
namespace: biological_process
def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
synonym: "inter neuron migration" EXACT [GOC:ah]
synonym: "inter-neuron migration" EXACT [GOC:ah]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000099 ! interneuron
relationship: results_in_movement_of CL:0000099 ! interneuron
created_by: ah
creation_date: 2016-02-01T14:04:32Z

[Term]
id: GO:1904937
name: sensory neuron migration
namespace: biological_process
def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000101 ! sensory neuron
relationship: results_in_movement_of CL:0000101 ! sensory neuron
created_by: ah
creation_date: 2016-02-01T14:15:50Z

[Term]
id: GO:1904942
name: regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
is_a: GO:1901210 ! regulation of cardiac chamber formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003211 ! cardiac ventricle formation
relationship: regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:16Z

[Term]
id: GO:1904943
name: negative regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie]
is_a: GO:1901211 ! negative regulation of cardiac chamber formation
is_a: GO:1904413 ! negative regulation of cardiac ventricle development
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003211 ! cardiac ventricle formation
relationship: negatively_regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:24Z

[Term]
id: GO:1904944
name: positive regulation of cardiac ventricle formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307]
synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie]
is_a: GO:1901212 ! positive regulation of cardiac chamber formation
is_a: GO:1904942 ! regulation of cardiac ventricle formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003211 ! cardiac ventricle formation
relationship: positively_regulates GO:0003211 ! cardiac ventricle formation
created_by: bc
creation_date: 2016-02-02T16:37:31Z

[Term]
id: GO:1904950
name: negative regulation of establishment of protein localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie]
synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie]
synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045184 ! establishment of protein localization
relationship: negatively_regulates GO:0045184 ! establishment of protein localization
created_by: mec
creation_date: 2016-02-05T09:59:24Z

[Term]
id: GO:1904951
name: positive regulation of establishment of protein localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]
synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie]
synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie]
synonym: "activation of protein positioning" NARROW [GOC:TermGenie]
synonym: "activation of protein recruitment" NARROW [GOC:TermGenie]
synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie]
synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie]
synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0070201 ! regulation of establishment of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045184 ! establishment of protein localization
relationship: positively_regulates GO:0045184 ! establishment of protein localization
created_by: mec
creation_date: 2016-02-05T09:59:32Z

[Term]
id: GO:1904987
name: regulation of endothelial cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042118 ! endothelial cell activation
relationship: regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:09Z

[Term]
id: GO:1904988
name: negative regulation of endothelial cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie]
is_a: GO:0050866 ! negative regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042118 ! endothelial cell activation
relationship: negatively_regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:18Z

[Term]
id: GO:1904989
name: positive regulation of endothelial cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059]
synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie]
is_a: GO:0050867 ! positive regulation of cell activation
is_a: GO:1904987 ! regulation of endothelial cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042118 ! endothelial cell activation
relationship: positively_regulates GO:0042118 ! endothelial cell activation
created_by: bc
creation_date: 2016-02-29T16:16:25Z

[Term]
id: GO:1905039
name: carboxylic acid transmembrane transport
namespace: biological_process
def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0055085 ! transmembrane transport
intersection_of: GO:0006810 ! transport
intersection_of: has_primary_input CHEBI:29067 ! carboxylic acid anion
intersection_of: results_in_transport_across GO:0016020 ! membrane
created_by: vw
creation_date: 2016-03-09T15:33:53Z

[Term]
id: GO:1905063
name: regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:14:53Z

[Term]
id: GO:1905064
name: negative regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:03Z

[Term]
id: GO:1905065
name: positive regulation of vascular associated smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079]
synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
relationship: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation
created_by: rph
creation_date: 2016-03-21T11:15:13Z

[Term]
id: GO:1905069
name: allantois development
namespace: biological_process
def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579]
synonym: "allantoic bud development" RELATED [GOC:TermGenie]
is_a: GO:1903867 ! extraembryonic membrane development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0004340 ! allantois
relationship: results_in_development_of UBERON:0004340 ! allantois
created_by: cls
creation_date: 2016-03-21T15:18:21Z

[Term]
id: GO:1905126
name: regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099640 ! axo-dendritic protein transport
relationship: regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:31Z

[Term]
id: GO:1905127
name: negative regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090317 ! negative regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0099640 ! axo-dendritic protein transport
relationship: negatively_regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:40Z

[Term]
id: GO:1905128
name: positive regulation of axo-dendritic protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152]
synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie]
synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie]
synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie]
synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie]
is_a: GO:0090316 ! positive regulation of intracellular protein transport
is_a: GO:1905126 ! regulation of axo-dendritic protein transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099640 ! axo-dendritic protein transport
relationship: positively_regulates GO:0099640 ! axo-dendritic protein transport
created_by: sl
creation_date: 2016-04-11T20:38:48Z

[Term]
id: GO:1905139
name: apical ectodermal ridge formation
namespace: biological_process
def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583]
synonym: "AER formation" RELATED [GOC:TermGenie]
synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
intersection_of: results_in_formation_of_anatomical_entity UBERON:0004356 ! apical ectodermal ridge
relationship: part_of GO:0035107 ! appendage morphogenesis
relationship: results_in_formation_of_anatomical_entity UBERON:0004356 ! apical ectodermal ridge
created_by: dph
creation_date: 2016-04-13T11:46:40Z

[Term]
id: GO:1905140
name: regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905139 ! apical ectodermal ridge formation
relationship: regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:40Z

[Term]
id: GO:1905141
name: negative regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "down regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "downregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "inhibition of AER formation" RELATED [GOC:TermGenie]
synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie]
synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905139 ! apical ectodermal ridge formation
relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:48Z

[Term]
id: GO:1905142
name: positive regulation of apical ectodermal ridge formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901]
synonym: "activation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
synonym: "upregulation of AER formation" RELATED [GOC:TermGenie]
synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie]
synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905140 ! regulation of apical ectodermal ridge formation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905139 ! apical ectodermal ridge formation
relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation
created_by: dph
creation_date: 2016-04-13T12:16:57Z

[Term]
id: GO:1905144
name: response to acetylcholine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497]
is_a: GO:0010033 ! response to organic substance
is_a: GO:1901698 ! response to nitrogen compound
is_a: GO:1901700 ! response to oxygen-containing compound
intersection_of: GO:0050896 ! response to stimulus
intersection_of: has_primary_input CHEBI:15355 ! acetylcholine
relationship: has_primary_input CHEBI:15355 ! acetylcholine
created_by: dos
creation_date: 2016-04-14T08:54:49Z

[Term]
id: GO:1905147
name: regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0043502 ! regulation of muscle adaptation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014895 ! smooth muscle hypertrophy
relationship: regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:07Z

[Term]
id: GO:1905148
name: negative regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014895 ! smooth muscle hypertrophy
relationship: negatively_regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:16Z

[Term]
id: GO:1905149
name: positive regulation of smooth muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164]
synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie]
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
is_a: GO:1905147 ! regulation of smooth muscle hypertrophy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014895 ! smooth muscle hypertrophy
relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy
created_by: bc
creation_date: 2016-04-15T12:47:24Z

[Term]
id: GO:1905153
name: regulation of membrane invagination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010324 ! membrane invagination
relationship: regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:43:54Z

[Term]
id: GO:1905154
name: negative regulation of membrane invagination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353]
synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010324 ! membrane invagination
relationship: negatively_regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:44:04Z

[Term]
id: GO:1905155
name: positive regulation of membrane invagination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
synonym: "activation of membrane invagination" NARROW [GOC:TermGenie]
synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie]
synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905153 ! regulation of membrane invagination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010324 ! membrane invagination
relationship: positively_regulates GO:0010324 ! membrane invagination
created_by: bf
creation_date: 2016-04-18T15:44:12Z

[Term]
id: GO:1905207
name: regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035051 ! cardiocyte differentiation
relationship: regulates GO:0035051 ! cardiocyte differentiation
created_by: bc
creation_date: 2016-06-02T07:20:01Z

[Term]
id: GO:1905208
name: negative regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035051 ! cardiocyte differentiation
relationship: negatively_regulates GO:0035051 ! cardiocyte differentiation
created_by: bc
creation_date: 2016-06-02T07:20:09Z

[Term]
id: GO:1905209
name: positive regulation of cardiocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713]
synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie]
synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035051 ! cardiocyte differentiation
relationship: positively_regulates GO:0035051 ! cardiocyte differentiation
created_by: bc
creation_date: 2016-06-02T07:20:16Z

[Term]
id: GO:1905213
name: negative regulation of mitotic chromosome condensation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:1902340 ! negative regulation of chromosome condensation
is_a: GO:1903379 ! regulation of mitotic chromosome condensation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007076 ! mitotic chromosome condensation
relationship: negatively_regulates GO:0007076 ! mitotic chromosome condensation
created_by: vw
creation_date: 2016-06-03T08:41:08Z

[Term]
id: GO:1905223
name: epicardium morphogenesis
namespace: biological_process
def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461]
synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie]
synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie]
synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie]
synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0009653 ! anatomical structure morphogenesis
intersection_of: GO:0009653 ! anatomical structure morphogenesis
intersection_of: results_in_morphogenesis_of UBERON:0002348 ! epicardium
relationship: results_in_morphogenesis_of UBERON:0002348 ! epicardium
created_by: rl
creation_date: 2016-06-07T10:02:32Z

[Term]
id: GO:1905268
name: negative regulation of chromatin organization
namespace: biological_process
alt_id: GO:0045798
alt_id: GO:1903309
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "down regulation of chromatin assembly or disassembly" RELATED []
synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin assembly or disassembly" RELATED []
synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin assembly or disassembly" RELATED []
synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "inhibition of chromatin assembly or disassembly" NARROW []
synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie]
synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "negative regulation of chromatin assembly or disassembly" RELATED []
synonym: "negative regulation of chromatin assembly/disassembly" EXACT []
synonym: "negative regulation of chromatin modification" RELATED []
synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1902275 ! regulation of chromatin organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006325 ! chromatin organization
relationship: negatively_regulates GO:0006325 ! chromatin organization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22766" xsd:anyURI
created_by: pr
creation_date: 2016-06-15T20:14:47Z

[Term]
id: GO:1905269
name: positive regulation of chromatin organization
namespace: biological_process
alt_id: GO:0045799
alt_id: GO:1903310
def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321]
synonym: "activation of chromatin assembly or disassembly" NARROW []
synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie]
synonym: "activation of chromatin organization" NARROW [GOC:TermGenie]
synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie]
synonym: "positive regulation of chromatin assembly or disassembly" RELATED []
synonym: "positive regulation of chromatin assembly/disassembly" RELATED []
synonym: "positive regulation of chromatin modification" RELATED []
synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "stimulation of chromatin assembly or disassembly" NARROW []
synonym: "up regulation of chromatin assembly or disassembly" RELATED []
synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin assembly or disassembly" RELATED []
synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin assembly or disassembly" EXACT []
synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie]
synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie]
is_a: GO:1902275 ! regulation of chromatin organization
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006325 ! chromatin organization
relationship: positively_regulates GO:0006325 ! chromatin organization
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22766" xsd:anyURI
created_by: pr
creation_date: 2016-06-15T20:14:56Z

[Term]
id: GO:1905276
name: regulation of epithelial tube formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072175 ! epithelial tube formation
relationship: regulates GO:0072175 ! epithelial tube formation
created_by: bhm
creation_date: 2016-06-20T09:35:41Z

[Term]
id: GO:1905277
name: negative regulation of epithelial tube formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072175 ! epithelial tube formation
relationship: negatively_regulates GO:0072175 ! epithelial tube formation
created_by: bhm
creation_date: 2016-06-20T09:35:49Z

[Term]
id: GO:1905278
name: positive regulation of epithelial tube formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie]
synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905276 ! regulation of epithelial tube formation
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072175 ! epithelial tube formation
relationship: positively_regulates GO:0072175 ! epithelial tube formation
created_by: bhm
creation_date: 2016-06-20T09:35:57Z

[Term]
id: GO:1905288
name: vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034390 ! smooth muscle cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0000359 ! vascular associated smooth muscle cell
relationship: occurs_in CL:0000359 ! vascular associated smooth muscle cell
created_by: rph
creation_date: 2016-06-23T13:24:20Z

[Term]
id: GO:1905292
name: regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014033 ! neural crest cell differentiation
relationship: regulates GO:0014033 ! neural crest cell differentiation
created_by: rl
creation_date: 2016-06-28T15:02:01Z

[Term]
id: GO:1905293
name: negative regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000737 ! negative regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0014033 ! neural crest cell differentiation
relationship: negatively_regulates GO:0014033 ! neural crest cell differentiation
created_by: rl
creation_date: 2016-06-28T15:02:09Z

[Term]
id: GO:1905294
name: positive regulation of neural crest cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157]
synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905292 ! regulation of neural crest cell differentiation
is_a: GO:2000738 ! positive regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0014033 ! neural crest cell differentiation
relationship: positively_regulates GO:0014033 ! neural crest cell differentiation
created_by: rl
creation_date: 2016-06-28T15:02:16Z

[Term]
id: GO:1905298
name: regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060576 ! intestinal epithelial cell development
relationship: regulates GO:0060576 ! intestinal epithelial cell development
created_by: rph
creation_date: 2016-06-30T11:40:47Z

[Term]
id: GO:1905299
name: negative regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905298 ! regulation of intestinal epithelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060576 ! intestinal epithelial cell development
relationship: negatively_regulates GO:0060576 ! intestinal epithelial cell development
created_by: rph
creation_date: 2016-06-30T11:40:55Z

[Term]
id: GO:1905300
name: positive regulation of intestinal epithelial cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268]
synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie]
synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905298 ! regulation of intestinal epithelial cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060576 ! intestinal epithelial cell development
relationship: positively_regulates GO:0060576 ! intestinal epithelial cell development
created_by: rph
creation_date: 2016-06-30T11:41:02Z

[Term]
id: GO:1905304
name: regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0110020 ! regulation of actomyosin structure organization
is_a: GO:1902115 ! regulation of organelle assembly
is_a: GO:1902903 ! regulation of supramolecular fiber organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055003 ! cardiac myofibril assembly
relationship: regulates GO:0055003 ! cardiac myofibril assembly
created_by: rl
creation_date: 2016-07-06T10:01:49Z

[Term]
id: GO:1905305
name: negative regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:1902116 ! negative regulation of organelle assembly
is_a: GO:1902904 ! negative regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055003 ! cardiac myofibril assembly
relationship: negatively_regulates GO:0055003 ! cardiac myofibril assembly
created_by: rl
creation_date: 2016-07-06T10:01:58Z

[Term]
id: GO:1905306
name: positive regulation of cardiac myofibril assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019]
synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie]
synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:1902117 ! positive regulation of organelle assembly
is_a: GO:1902905 ! positive regulation of supramolecular fiber organization
is_a: GO:1905304 ! regulation of cardiac myofibril assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055003 ! cardiac myofibril assembly
relationship: positively_regulates GO:0055003 ! cardiac myofibril assembly
created_by: rl
creation_date: 2016-07-06T10:02:07Z

[Term]
id: GO:1905310
name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
created_by: rl
creation_date: 2016-07-11T17:34:26Z

[Term]
id: GO:1905311
name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
created_by: rl
creation_date: 2016-07-11T17:34:35Z

[Term]
id: GO:1905312
name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518]
synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
relationship: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis
created_by: rl
creation_date: 2016-07-11T17:34:43Z

[Term]
id: GO:1905315
name: cell proliferation involved in endocardial cushion morphogenesis
namespace: biological_process
def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: rl
creation_date: 2016-07-12T13:56:36Z

[Term]
id: GO:1905319
name: mesenchymal stem cell migration
namespace: biological_process
def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476]
is_a: GO:0016477 ! cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: results_in_movement_of CL:0000134 ! mesenchymal stem cell
relationship: results_in_movement_of CL:0000134 ! mesenchymal stem cell
created_by: sl
creation_date: 2016-07-14T17:13:02Z

[Term]
id: GO:1905320
name: regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905319 ! mesenchymal stem cell migration
relationship: regulates GO:1905319 ! mesenchymal stem cell migration
created_by: sl
creation_date: 2016-07-15T22:19:14Z

[Term]
id: GO:1905321
name: negative regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905319 ! mesenchymal stem cell migration
relationship: negatively_regulates GO:1905319 ! mesenchymal stem cell migration
created_by: sl
creation_date: 2016-07-15T22:19:22Z

[Term]
id: GO:1905322
name: positive regulation of mesenchymal stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297]
synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie]
synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:1905320 ! regulation of mesenchymal stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905319 ! mesenchymal stem cell migration
relationship: positively_regulates GO:1905319 ! mesenchymal stem cell migration
created_by: sl
creation_date: 2016-07-15T22:19:29Z

[Term]
id: GO:1905330
name: regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002009 ! morphogenesis of an epithelium
relationship: regulates GO:0002009 ! morphogenesis of an epithelium
created_by: bhm
creation_date: 2016-07-22T07:13:49Z

[Term]
id: GO:1905331
name: negative regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002009 ! morphogenesis of an epithelium
relationship: negatively_regulates GO:0002009 ! morphogenesis of an epithelium
created_by: bhm
creation_date: 2016-07-22T07:13:57Z

[Term]
id: GO:1905332
name: positive regulation of morphogenesis of an epithelium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]
comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay).
synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie]
synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002009 ! morphogenesis of an epithelium
relationship: positively_regulates GO:0002009 ! morphogenesis of an epithelium
created_by: bhm
creation_date: 2016-07-22T07:14:05Z

[Term]
id: GO:1905349
name: ciliary transition zone assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032]
synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilial transition zone formation" EXACT [GOC:TermGenie]
synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie]
synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie]
synonym: "cilium transition zone formation" EXACT [GOC:TermGenie]
is_a: GO:0022607 ! cellular component assembly
intersection_of: GO:0022607 ! cellular component assembly
intersection_of: results_in_assembly_of GO:0035869 ! ciliary transition zone
relationship: part_of GO:0060271 ! cilium assembly
relationship: results_in_assembly_of GO:0035869 ! ciliary transition zone
created_by: pr
creation_date: 2016-08-04T14:49:43Z

[Term]
id: GO:1905383
name: protein localization to presynapse
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494]
synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494]
is_a: GO:0035418 ! protein localization to synapse
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0098793 ! presynapse
relationship: has_target_end_location GO:0098793 ! presynapse
created_by: dos
creation_date: 2016-08-18T14:42:59Z

[Term]
id: GO:1905384
name: regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902473 ! regulation of protein localization to synapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905383 ! protein localization to presynapse
relationship: regulates GO:1905383 ! protein localization to presynapse
created_by: dos
creation_date: 2016-08-18T14:56:00Z

[Term]
id: GO:1905385
name: negative regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905384 ! regulation of protein localization to presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905383 ! protein localization to presynapse
relationship: negatively_regulates GO:1905383 ! protein localization to presynapse
created_by: dos
creation_date: 2016-08-18T14:56:08Z

[Term]
id: GO:1905386
name: positive regulation of protein localization to presynapse
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494]
synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie]
synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie]
synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie]
is_a: GO:1902474 ! positive regulation of protein localization to synapse
is_a: GO:1905384 ! regulation of protein localization to presynapse
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905383 ! protein localization to presynapse
relationship: positively_regulates GO:1905383 ! protein localization to presynapse
created_by: dos
creation_date: 2016-08-18T14:56:21Z

[Term]
id: GO:1905432
name: regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0099177 ! regulation of trans-synaptic signaling
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
relationship: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
created_by: bf
creation_date: 2016-09-14T10:56:47Z

[Term]
id: GO:1905433
name: negative regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
relationship: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
created_by: bf
creation_date: 2016-09-14T10:56:55Z

[Term]
id: GO:1905434
name: positive regulation of retrograde trans-synaptic signaling by neuropeptide
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629]
synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie]
synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf]
synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
relationship: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide
created_by: bf
creation_date: 2016-09-14T10:57:02Z

[Term]
id: GO:1905453
name: regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002318 ! myeloid progenitor cell differentiation
relationship: regulates GO:0002318 ! myeloid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:18Z

[Term]
id: GO:1905454
name: negative regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation
relationship: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:26Z

[Term]
id: GO:1905455
name: positive regulation of myeloid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation
relationship: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:33Z

[Term]
id: GO:1905456
name: regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002320 ! lymphoid progenitor cell differentiation
relationship: regulates GO:0002320 ! lymphoid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:40Z

[Term]
id: GO:1905457
name: negative regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation
relationship: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:48Z

[Term]
id: GO:1905458
name: positive regulation of lymphoid progenitor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503]
synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie]
synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation
relationship: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation
created_by: rz
creation_date: 2016-09-16T12:32:55Z

[Term]
id: GO:1905459
name: regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
relationship: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
created_by: rph
creation_date: 2016-09-19T11:33:54Z

[Term]
id: GO:1905460
name: negative regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
relationship: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
created_by: rph
creation_date: 2016-09-19T11:34:03Z

[Term]
id: GO:1905461
name: positive regulation of vascular associated smooth muscle cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107]
synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie]
synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie]
synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie]
is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process
is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
relationship: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process
created_by: rph
creation_date: 2016-09-19T11:34:10Z

[Term]
id: GO:1905475
name: regulation of protein localization to membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072657 ! protein localization to membrane
relationship: regulates GO:0072657 ! protein localization to membrane
created_by: bc
creation_date: 2016-09-21T16:20:03Z

[Term]
id: GO:1905476
name: negative regulation of protein localization to membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072657 ! protein localization to membrane
relationship: negatively_regulates GO:0072657 ! protein localization to membrane
created_by: bc
creation_date: 2016-09-21T16:20:10Z

[Term]
id: GO:1905477
name: positive regulation of protein localization to membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]
synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905475 ! regulation of protein localization to membrane
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072657 ! protein localization to membrane
relationship: positively_regulates GO:0072657 ! protein localization to membrane
created_by: bc
creation_date: 2016-09-21T16:20:18Z

[Term]
id: GO:1905483
name: regulation of motor neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097475 ! motor neuron migration
relationship: regulates GO:0097475 ! motor neuron migration
created_by: hbye
creation_date: 2016-09-23T12:49:54Z

[Term]
id: GO:1905484
name: negative regulation of motor neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001223 ! negative regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097475 ! motor neuron migration
relationship: negatively_regulates GO:0097475 ! motor neuron migration
created_by: hbye
creation_date: 2016-09-23T12:50:11Z

[Term]
id: GO:1905485
name: positive regulation of motor neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie]
synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie]
synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie]
is_a: GO:1905483 ! regulation of motor neuron migration
is_a: GO:2001224 ! positive regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097475 ! motor neuron migration
relationship: positively_regulates GO:0097475 ! motor neuron migration
created_by: hbye
creation_date: 2016-09-23T12:50:19Z

[Term]
id: GO:1905492
name: positive regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839]
synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie]
synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048755 ! branching morphogenesis of a nerve
relationship: positively_regulates GO:0048755 ! branching morphogenesis of a nerve
created_by: hbye
creation_date: 2016-09-23T14:11:52Z

[Term]
id: GO:1905503
name: regulation of motile cilium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "regulation of motile primary cilium assembly" RELATED []
synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902017 ! regulation of cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044458 ! motile cilium assembly
relationship: regulates GO:0044458 ! motile cilium assembly
created_by: krc
creation_date: 2016-09-27T18:27:47Z

[Term]
id: GO:1905504
name: negative regulation of motile cilium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of motile primary cilium assembly" RELATED []
synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:1902018 ! negative regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044458 ! motile cilium assembly
relationship: negatively_regulates GO:0044458 ! motile cilium assembly
created_by: krc
creation_date: 2016-09-27T18:27:55Z

[Term]
id: GO:1905505
name: positive regulation of motile cilium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]
synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie]
synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie]
synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of motile primary cilium assembly" RELATED []
synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie]
synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie]
is_a: GO:0045724 ! positive regulation of cilium assembly
is_a: GO:1905503 ! regulation of motile cilium assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044458 ! motile cilium assembly
relationship: positively_regulates GO:0044458 ! motile cilium assembly
created_by: krc
creation_date: 2016-09-27T18:28:03Z

[Term]
id: GO:1905516
name: positive regulation of fertilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]
synonym: "activation of fertilization" NARROW [GOC:TermGenie]
synonym: "activation of syngamy" NARROW [GOC:TermGenie]
synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie]
synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie]
synonym: "upregulation of fertilization" EXACT [GOC:TermGenie]
synonym: "upregulation of syngamy" EXACT [GOC:TermGenie]
is_a: GO:0080154 ! regulation of fertilization
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009566 ! fertilization
relationship: positively_regulates GO:0009566 ! fertilization
created_by: pr
creation_date: 2016-09-30T14:32:32Z

[Term]
id: GO:1905553
name: regulation of blood vessel branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:1905330 ! regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001569 ! branching involved in blood vessel morphogenesis
relationship: regulates GO:0001569 ! branching involved in blood vessel morphogenesis
created_by: nc
creation_date: 2016-10-12T14:19:33Z

[Term]
id: GO:1905554
name: negative regulation of vessel branching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis
relationship: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis
created_by: nc
creation_date: 2016-10-12T14:19:41Z

[Term]
id: GO:1905555
name: positive regulation of blood vessel branching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie]
synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie]
synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie]
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
is_a: GO:1905553 ! regulation of blood vessel branching
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis
relationship: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis
created_by: nc
creation_date: 2016-10-12T14:19:49Z

[Term]
id: GO:1905557
name: regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010549 ! regulation of membrane disassembly
is_a: GO:0010564 ! regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007077 ! mitotic nuclear membrane disassembly
relationship: regulates GO:0007077 ! mitotic nuclear membrane disassembly
created_by: hbye
creation_date: 2016-10-14T13:14:57Z

[Term]
id: GO:1905558
name: negative regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007077 ! mitotic nuclear membrane disassembly
relationship: negatively_regulates GO:0007077 ! mitotic nuclear membrane disassembly
created_by: hbye
creation_date: 2016-10-14T13:15:08Z

[Term]
id: GO:1905559
name: positive regulation of mitotic nuclear envelope disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790]
synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie]
synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie]
synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090068 ! positive regulation of cell cycle process
is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007077 ! mitotic nuclear membrane disassembly
relationship: positively_regulates GO:0007077 ! mitotic nuclear membrane disassembly
created_by: hbye
creation_date: 2016-10-14T13:15:17Z

[Term]
id: GO:1905562
name: regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
is_a: GO:0001936 ! regulation of endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0101023 ! vascular endothelial cell proliferation
relationship: regulates GO:0101023 ! vascular endothelial cell proliferation
created_by: nc
creation_date: 2016-10-17T09:24:17Z

[Term]
id: GO:1905563
name: negative regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0001937 ! negative regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation
relationship: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation
created_by: nc
creation_date: 2016-10-17T09:24:26Z

[Term]
id: GO:1905564
name: positive regulation of vascular endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774]
synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0001938 ! positive regulation of endothelial cell proliferation
is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0101023 ! vascular endothelial cell proliferation
relationship: positively_regulates GO:0101023 ! vascular endothelial cell proliferation
created_by: nc
creation_date: 2016-10-17T09:24:35Z

[Term]
id: GO:1905606
name: regulation of presynapse assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
subset: goslim_synapse
synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051963 ! regulation of synapse assembly
is_a: GO:0099174 ! regulation of presynapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0099054 ! presynapse assembly
relationship: regulates GO:0099054 ! presynapse assembly
created_by: bc
creation_date: 2016-10-27T16:08:13Z

[Term]
id: GO:1905607
name: negative regulation of presynapse assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051964 ! negative regulation of synapse assembly
is_a: GO:1905606 ! regulation of presynapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0099054 ! presynapse assembly
relationship: negatively_regulates GO:0099054 ! presynapse assembly
created_by: bc
creation_date: 2016-10-27T16:08:20Z

[Term]
id: GO:1905608
name: positive regulation of presynapse assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie]
synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie]
synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie]
synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie]
synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905606 ! regulation of presynapse assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0099054 ! presynapse assembly
relationship: positively_regulates GO:0099054 ! presynapse assembly
created_by: bc
creation_date: 2016-10-27T16:08:28Z

[Term]
id: GO:1905627
name: regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042427 ! serotonin biosynthetic process
relationship: regulates GO:0042427 ! serotonin biosynthetic process
created_by: pad
creation_date: 2016-10-31T14:26:20Z

[Term]
id: GO:1905628
name: negative regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie]
synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042427 ! serotonin biosynthetic process
relationship: negatively_regulates GO:0042427 ! serotonin biosynthetic process
created_by: pad
creation_date: 2016-10-31T14:26:28Z

[Term]
id: GO:1905629
name: positive regulation of serotonin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596]
synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of serotonin formation" NARROW [GOC:TermGenie]
synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie]
synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:1905627 ! regulation of serotonin biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042427 ! serotonin biosynthetic process
relationship: positively_regulates GO:0042427 ! serotonin biosynthetic process
created_by: pad
creation_date: 2016-10-31T14:26:36Z

[Term]
id: GO:1905634
name: regulation of protein localization to chromatin
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]
synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071168 ! protein localization to chromatin
relationship: regulates GO:0071168 ! protein localization to chromatin
created_by: pga
creation_date: 2016-11-01T16:33:52Z

[Term]
id: GO:1905651
name: regulation of artery morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048844 ! artery morphogenesis
relationship: regulates GO:0048844 ! artery morphogenesis
created_by: rph
creation_date: 2016-11-09T12:19:37Z

[Term]
id: GO:1905652
name: negative regulation of artery morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie]
is_a: GO:1905651 ! regulation of artery morphogenesis
is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048844 ! artery morphogenesis
relationship: negatively_regulates GO:0048844 ! artery morphogenesis
created_by: rph
creation_date: 2016-11-09T12:19:53Z

[Term]
id: GO:1905653
name: positive regulation of artery morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411]
synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie]
synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie]
synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:1905651 ! regulation of artery morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048844 ! artery morphogenesis
relationship: positively_regulates GO:0048844 ! artery morphogenesis
created_by: rph
creation_date: 2016-11-09T12:20:01Z

[Term]
id: GO:1905690
name: nucleus disassembly
namespace: biological_process
def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie]
synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie]
is_a: GO:0006997 ! nucleus organization
is_a: GO:1903008 ! organelle disassembly
intersection_of: GO:0022411 ! cellular component disassembly
intersection_of: results_in_disassembly_of GO:0005634 ! nucleus
relationship: results_in_disassembly_of GO:0005634 ! nucleus
created_by: pr
creation_date: 2016-11-14T13:38:57Z

[Term]
id: GO:1905720
name: cytoplasmic microtubule bundle
namespace: cellular_component
def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291]
synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie]
synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie]
is_a: GO:0097427 ! microtubule bundle
intersection_of: GO:0097427 ! microtubule bundle
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0005737 ! cytoplasm
created_by: mah
creation_date: 2016-11-24T16:52:02Z

[Term]
id: GO:1905755
name: protein localization to cytoplasmic microtubule
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031]
synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie]
is_a: GO:0035372 ! protein localization to microtubule
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0005881 ! cytoplasmic microtubule
relationship: has_target_end_location GO:0005881 ! cytoplasmic microtubule
created_by: mah
creation_date: 2016-12-12T15:31:07Z

[Term]
id: GO:1905770
name: regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048333 ! mesodermal cell differentiation
relationship: regulates GO:0048333 ! mesodermal cell differentiation
created_by: rph
creation_date: 2016-12-21T12:44:13Z

[Term]
id: GO:1905771
name: negative regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048333 ! mesodermal cell differentiation
relationship: negatively_regulates GO:0048333 ! mesodermal cell differentiation
created_by: rph
creation_date: 2016-12-21T12:44:23Z

[Term]
id: GO:1905772
name: positive regulation of mesodermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923]
synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie]
synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie]
synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:1905770 ! regulation of mesodermal cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048333 ! mesodermal cell differentiation
relationship: positively_regulates GO:0048333 ! mesodermal cell differentiation
created_by: rph
creation_date: 2016-12-21T12:44:32Z

[Term]
id: GO:1905806
name: regulation of synapse pruning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
subset: goslim_synapse
synonym: "regulation of synapse clearance" EXACT []
synonym: "regulation of synapse disassembly" EXACT syngo_official_label []
synonym: "regulation of synapse elimination" EXACT []
synonym: "regulation of synapse removal" EXACT []
is_a: GO:0050807 ! regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0098883 ! synapse pruning
relationship: regulates GO:0098883 ! synapse pruning
created_by: tb
creation_date: 2017-01-11T22:03:15Z

[Term]
id: GO:1905807
name: negative regulation of synapse pruning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
is_a: GO:1905806 ! regulation of synapse pruning
is_a: GO:1905809 ! negative regulation of synapse organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0098883 ! synapse pruning
relationship: negatively_regulates GO:0098883 ! synapse pruning
created_by: tb
creation_date: 2017-01-11T22:03:24Z

[Term]
id: GO:1905808
name: positive regulation of synapse pruning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie]
synonym: "regulation of synapse clearance" BROAD []
synonym: "regulation of synapse disassembly" BROAD []
synonym: "regulation of synapse elimination" BROAD []
synonym: "regulation of synapse removal" BROAD []
synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie]
synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:1905806 ! regulation of synapse pruning
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0098883 ! synapse pruning
relationship: positively_regulates GO:0098883 ! synapse pruning
created_by: tb
creation_date: 2017-01-11T22:03:33Z

[Term]
id: GO:1905809
name: negative regulation of synapse organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093]
synonym: "down regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse development" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie]
synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse development" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie]
synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie]
synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie]
synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie]
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051129 ! negative regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050808 ! synapse organization
relationship: negatively_regulates GO:0050808 ! synapse organization
created_by: tb
creation_date: 2017-01-11T22:03:41Z

[Term]
id: GO:1905821
name: positive regulation of chromosome condensation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547]
synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie]
synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie]
synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie]
synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie]
is_a: GO:0060623 ! regulation of chromosome condensation
is_a: GO:2001252 ! positive regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030261 ! chromosome condensation
relationship: positively_regulates GO:0030261 ! chromosome condensation
created_by: bhm
creation_date: 2017-01-13T14:13:44Z

[Term]
id: GO:1905833
name: negative regulation of microtubule nucleation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799]
synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie]
synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031115 ! negative regulation of microtubule polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007020 ! microtubule nucleation
relationship: negatively_regulates GO:0007020 ! microtubule nucleation
created_by: hbye
creation_date: 2017-01-17T12:00:56Z

[Term]
id: GO:1905867
name: epididymis development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12388089]
synonym: "epididymus development" EXACT [GOC:TermGenie]
is_a: GO:0035295 ! tube development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001301 ! epididymis
relationship: results_in_development_of UBERON:0001301 ! epididymis
created_by: sl
creation_date: 2017-01-27T00:00:33Z

[Term]
id: GO:1905871
name: regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:0032880 ! regulation of protein localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:1902463 ! protein localization to cell leading edge
relationship: regulates GO:1902463 ! protein localization to cell leading edge
created_by: sl
creation_date: 2017-01-27T19:34:55Z

[Term]
id: GO:1905872
name: negative regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903828 ! negative regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:1902463 ! protein localization to cell leading edge
relationship: negatively_regulates GO:1902463 ! protein localization to cell leading edge
created_by: sl
creation_date: 2017-01-27T19:35:04Z

[Term]
id: GO:1905873
name: positive regulation of protein localization to cell leading edge
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884]
synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie]
synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie]
synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie]
synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie]
is_a: GO:1903829 ! positive regulation of protein localization
is_a: GO:1905871 ! regulation of protein localization to cell leading edge
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:1902463 ! protein localization to cell leading edge
relationship: positively_regulates GO:1902463 ! protein localization to cell leading edge
created_by: sl
creation_date: 2017-01-27T19:35:13Z

[Term]
id: GO:1905879
name: regulation of oogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048477 ! oogenesis
relationship: regulates GO:0048477 ! oogenesis
created_by: hbye
creation_date: 2017-01-31T09:31:05Z

[Term]
id: GO:1905880
name: negative regulation of oogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of ovum development" EXACT [GOC:TermGenie]
synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie]
synonym: "inhibition of ovum development" NARROW [GOC:TermGenie]
synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048477 ! oogenesis
relationship: negatively_regulates GO:0048477 ! oogenesis
created_by: hbye
creation_date: 2017-01-31T09:31:15Z

[Term]
id: GO:1905881
name: positive regulation of oogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]
synonym: "activation of oogenesis" NARROW [GOC:TermGenie]
synonym: "activation of ovum development" NARROW [GOC:TermGenie]
synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie]
synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of ovum development" EXACT [GOC:TermGenie]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905879 ! regulation of oogenesis
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048477 ! oogenesis
relationship: positively_regulates GO:0048477 ! oogenesis
created_by: hbye
creation_date: 2017-01-31T09:31:23Z

[Term]
id: GO:1905899
name: regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
is_a: GO:1901861 ! regulation of muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048745 ! smooth muscle tissue development
relationship: regulates GO:0048745 ! smooth muscle tissue development
created_by: bhm
creation_date: 2017-02-01T14:31:16Z

[Term]
id: GO:1905900
name: negative regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie]
is_a: GO:1901862 ! negative regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048745 ! smooth muscle tissue development
relationship: negatively_regulates GO:0048745 ! smooth muscle tissue development
created_by: bhm
creation_date: 2017-02-01T14:31:24Z

[Term]
id: GO:1905901
name: positive regulation of smooth muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716]
synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie]
synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie]
is_a: GO:1901863 ! positive regulation of muscle tissue development
is_a: GO:1905899 ! regulation of smooth muscle tissue development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048745 ! smooth muscle tissue development
relationship: positively_regulates GO:0048745 ! smooth muscle tissue development
created_by: bhm
creation_date: 2017-02-01T14:31:33Z

[Term]
id: GO:1905902
name: regulation of mesoderm formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001707 ! mesoderm formation
relationship: regulates GO:0001707 ! mesoderm formation
created_by: rph
creation_date: 2017-02-03T12:28:20Z

[Term]
id: GO:1905903
name: negative regulation of mesoderm formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000381 ! negative regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001707 ! mesoderm formation
relationship: negatively_regulates GO:0001707 ! mesoderm formation
created_by: rph
creation_date: 2017-02-03T12:28:29Z

[Term]
id: GO:1905904
name: positive regulation of mesoderm formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491]
synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie]
synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie]
synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie]
is_a: GO:1905902 ! regulation of mesoderm formation
is_a: GO:2000382 ! positive regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001707 ! mesoderm formation
relationship: positively_regulates GO:0001707 ! mesoderm formation
created_by: rph
creation_date: 2017-02-03T12:28:38Z

[Term]
id: GO:1905921
name: regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008292 ! acetylcholine biosynthetic process
relationship: regulates GO:0008292 ! acetylcholine biosynthetic process
created_by: bc
creation_date: 2017-02-08T13:08:30Z

[Term]
id: GO:1905922
name: negative regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process
relationship: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process
created_by: bc
creation_date: 2017-02-08T13:08:39Z

[Term]
id: GO:1905923
name: positive regulation of acetylcholine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328]
synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie]
synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie]
synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process
is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008292 ! acetylcholine biosynthetic process
relationship: positively_regulates GO:0008292 ! acetylcholine biosynthetic process
created_by: bc
creation_date: 2017-02-08T13:08:48Z

[Term]
id: GO:1905936
name: regulation of germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
is_a: GO:0042127 ! regulation of cell population proliferation
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0036093 ! germ cell proliferation
relationship: regulates GO:0036093 ! germ cell proliferation
created_by: hbye
creation_date: 2017-02-09T14:51:31Z

[Term]
id: GO:1905937
name: negative regulation of germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0036093 ! germ cell proliferation
relationship: negatively_regulates GO:0036093 ! germ cell proliferation
created_by: hbye
creation_date: 2017-02-09T14:51:41Z

[Term]
id: GO:1905938
name: positive regulation of germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie]
synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie]
synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905936 ! regulation of germ cell proliferation
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0036093 ! germ cell proliferation
relationship: positively_regulates GO:0036093 ! germ cell proliferation
created_by: hbye
creation_date: 2017-02-09T14:51:51Z

[Term]
id: GO:1905939
name: regulation of gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008406 ! gonad development
relationship: regulates GO:0008406 ! gonad development
created_by: hbye
creation_date: 2017-02-09T17:01:50Z

[Term]
id: GO:1905940
name: negative regulation of gonad development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "down regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of gonad development" NARROW [GOC:TermGenie]
synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000242 ! negative regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008406 ! gonad development
relationship: negatively_regulates GO:0008406 ! gonad development
created_by: hbye
creation_date: 2017-02-09T17:01:59Z

[Term]
id: GO:1905941
name: positive regulation of gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467]
synonym: "activation of gonad development" NARROW [GOC:TermGenie]
synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie]
synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie]
synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of gonad development" EXACT [GOC:TermGenie]
synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000243 ! positive regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008406 ! gonad development
relationship: positively_regulates GO:0008406 ! gonad development
created_by: hbye
creation_date: 2017-02-09T17:02:08Z

[Term]
id: GO:1905952
name: regulation of lipid localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0032879 ! regulation of localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010876 ! lipid localization
relationship: regulates GO:0010876 ! lipid localization
created_by: rz
creation_date: 2017-02-21T12:12:22Z

[Term]
id: GO:1905953
name: negative regulation of lipid localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie]
synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie]
synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010876 ! lipid localization
relationship: negatively_regulates GO:0010876 ! lipid localization
created_by: rz
creation_date: 2017-02-21T12:12:41Z

[Term]
id: GO:1905954
name: positive regulation of lipid localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]
synonym: "activation of lipid localisation" NARROW [GOC:TermGenie]
synonym: "activation of lipid localization" NARROW [GOC:TermGenie]
synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie]
synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:1905952 ! regulation of lipid localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010876 ! lipid localization
relationship: positively_regulates GO:0010876 ! lipid localization
created_by: rz
creation_date: 2017-02-21T12:12:49Z

[Term]
id: GO:1905955
name: negative regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061154 ! endothelial tube morphogenesis
relationship: negatively_regulates GO:0061154 ! endothelial tube morphogenesis
created_by: rph
creation_date: 2017-02-21T15:17:31Z

[Term]
id: GO:1905956
name: positive regulation of endothelial tube morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718]
synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie]
synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:1901509 ! regulation of endothelial tube morphogenesis
is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061154 ! endothelial tube morphogenesis
relationship: positively_regulates GO:0061154 ! endothelial tube morphogenesis
created_by: rph
creation_date: 2017-02-21T15:17:39Z

[Term]
id: GO:1990009
name: retinal cell apoptotic process
namespace: biological_process
alt_id: GO:0046674
def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675]
synonym: "induction of retinal programmed cell death" RELATED []
is_a: GO:0006915 ! apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0009004 ! retinal cell
relationship: occurs_in CL:0009004 ! retinal cell
created_by: pr
creation_date: 2012-12-12T10:15:08Z

[Term]
id: GO:1990010
name: compound eye retinal cell apoptotic process
namespace: biological_process
def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768]
is_a: GO:1990009 ! retinal cell apoptotic process
intersection_of: GO:0006915 ! apoptotic process
intersection_of: occurs_in CL:0009001 ! compound eye retinal cell
relationship: occurs_in CL:0009001 ! compound eye retinal cell
created_by: pr
creation_date: 2012-12-12T10:21:07Z

[Term]
id: GO:1990182
name: exosomal secretion
namespace: biological_process
def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898]
synonym: "exosomal protein secretion" NARROW [PMID:18617898]
synonym: "exosomal secretory pathway" EXACT [PMID:18617898]
synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd]
synonym: "multi-vesicular body fusion with plasma membrane" EXACT []
synonym: "secretion of exosome" EXACT [PMID:18617898]
is_a: GO:0006887 ! exocytosis
is_a: GO:0051650 ! establishment of vesicle localization
intersection_of: GO:0006887 ! exocytosis
intersection_of: has_primary_input GO:0070062 ! extracellular exosome
relationship: has_primary_input GO:0070062 ! extracellular exosome
relationship: part_of GO:0097734 ! extracellular exosome biogenesis
property_value: RO:0002161 NCBITaxon:4890
created_by: hjd
creation_date: 2013-09-04T21:08:14Z

[Term]
id: GO:1990234
name: transferase complex
namespace: cellular_component
def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]
is_a: GO:1902494 ! catalytic complex
intersection_of: GO:1902494 ! catalytic complex
intersection_of: capable_of GO:0016740 ! transferase activity
relationship: capable_of GO:0016740 ! transferase activity
created_by: bhm
creation_date: 2013-11-12T13:20:12Z

[Term]
id: GO:1990280
name: RNA localization to chromatin
namespace: biological_process
def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262]
synonym: "RNA localisation to chromatin" EXACT []
is_a: GO:0006403 ! RNA localization
intersection_of: GO:0006403 ! RNA localization
intersection_of: has_target_end_location GO:0000785 ! chromatin
relationship: has_target_end_location GO:0000785 ! chromatin
created_by: mah
creation_date: 2014-01-30T15:55:34Z

[Term]
id: GO:1990351
name: transporter complex
namespace: cellular_component
def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]
comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay).
is_a: GO:0032991 ! protein-containing complex
intersection_of: GO:0032991 ! protein-containing complex
intersection_of: capable_of GO:0005215 ! transporter activity
relationship: capable_of GO:0005215 ! transporter activity
created_by: bhm
creation_date: 2014-03-26T14:23:27Z

[Term]
id: GO:1990375
name: baculum development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296]
synonym: "os penis development" EXACT [GOC:sl]
synonym: "penile bone development" EXACT [GOC:sl]
synonym: "penis bone development" EXACT [GOC:sl]
is_a: GO:0048608 ! reproductive structure development
intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0006435 ! os penis
relationship: results_in_development_of UBERON:0006435 ! os penis
created_by: sl
creation_date: 2014-05-01T23:59:13Z

[Term]
id: GO:1990502
name: dense core granule maturation
namespace: biological_process
def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674]
synonym: "dense core vesicle maturation" EXACT []
is_a: GO:0061792 ! secretory granule maturation
intersection_of: GO:0021700 ! developmental maturation
intersection_of: results_in_maturation_of GO:0031045 ! dense core granule
relationship: results_in_maturation_of GO:0031045 ! dense core granule
created_by: kmv
creation_date: 2014-09-30T20:35:11Z

[Term]
id: GO:1990705
name: cholangiocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010]
synonym: "hepatoblast proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:1000488 ! cholangiocyte
relationship: acts_on_population_of CL:1000488 ! cholangiocyte
creation_date: 2015-03-16T23:23:50Z

[Term]
id: GO:1990748
name: cellular detoxification
namespace: biological_process
def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]
is_a: GO:0009987 ! cellular process
is_a: GO:0098754 ! detoxification
intersection_of: GO:0098754 ! detoxification
intersection_of: occurs_in CL:0000000 ! cell
relationship: occurs_in CL:0000000 ! cell
relationship: part_of GO:0097237 ! cellular response to toxic substance
created_by: vw
creation_date: 2015-05-18T16:17:46Z

[Term]
id: GO:1990765
name: colon smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253]
is_a: GO:0006939 ! smooth muscle contraction
intersection_of: GO:0006939 ! smooth muscle contraction
intersection_of: occurs_in UBERON:0001155 ! colon
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: occurs_in UBERON:0001155 ! colon
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of GO:0014827 ! intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-10T18:29:21Z

[Term]
id: GO:1990768
name: gastric mucosal blood circulation
namespace: biological_process
def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413]
synonym: "stomach mucosal blood circulation" EXACT []
is_a: GO:0008015 ! blood circulation
intersection_of: GO:0008015 ! blood circulation
intersection_of: occurs_in UBERON:0004786 ! gastrointestinal system mucosa
relationship: occurs_in UBERON:0004786 ! gastrointestinal system mucosa
created_by: sl
creation_date: 2015-06-10T20:11:09Z

[Term]
id: GO:1990770
name: small intestine smooth muscle contraction
namespace: biological_process
def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626]
is_a: GO:0006939 ! smooth muscle contraction
intersection_of: GO:0006939 ! smooth muscle contraction
intersection_of: occurs_in UBERON:0002108 ! small intestine
relationship: in_taxon NCBITaxon:7742 {all_only="true"} ! Vertebrata <vertebrates>
relationship: occurs_in UBERON:0002108 ! small intestine
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of GO:0014827 ! intestine smooth muscle contraction
created_by: sl
creation_date: 2015-06-11T18:02:33Z

[Term]
id: GO:1990778
name: protein localization to cell periphery
namespace: biological_process
def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]
is_a: GO:0008104 ! protein localization
intersection_of: GO:0008104 ! protein localization
intersection_of: has_target_end_location GO:0071944 ! cell periphery
relationship: has_target_end_location GO:0071944 ! cell periphery
creation_date: 2015-06-18T22:37:39Z

[Term]
id: GO:1990849
name: vacuolar localization
namespace: biological_process
def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797]
synonym: "maintenance of vacuolar localization" EXACT []
synonym: "maintenance of vacuolar location" NARROW []
synonym: "maintenance of vacuole localization" EXACT []
synonym: "maintenance of vacuole location" EXACT []
is_a: GO:0051640 ! organelle localization
intersection_of: GO:0051179 ! localization
intersection_of: has_primary_input GO:0005773 ! vacuole
relationship: has_primary_input GO:0005773 ! vacuole
property_value: IAO:0000233 "https://github.com/geneontology/go-ontology/issues/22182" xsd:anyURI
created_by: mcc
creation_date: 2015-09-10T08:16:02Z

[Term]
id: GO:1990863
name: acinar cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538]
synonym: "acinic cell proliferation" EXACT []
synonym: "acinous cell proliferation" EXACT []
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000622 ! acinar cell
relationship: acts_on_population_of CL:0000622 ! acinar cell
created_by: sl
creation_date: 2015-09-25T14:26:09Z

[Term]
id: GO:1990874
name: vascular associated smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]
synonym: "vascular smooth muscle cell proliferation" EXACT []
synonym: "VSMC proliferation" EXACT []
is_a: GO:0048659 ! smooth muscle cell proliferation
intersection_of: GO:0008283 ! cell population proliferation
intersection_of: acts_on_population_of CL:0000359 ! vascular associated smooth muscle cell
relationship: acts_on_population_of CL:0000359 ! vascular associated smooth muscle cell
created_by: sl
creation_date: 2015-09-29T16:34:59Z

[Term]
id: GO:1990904
name: ribonucleoprotein complex
namespace: cellular_component
alt_id: GO:0030529
alt_id: GO:1990903
def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]
subset: goslim_pir
synonym: "extracellular ribonucleoprotein complex" NARROW []
synonym: "intracellular ribonucleoprotein complex" NARROW []
synonym: "protein-RNA complex" EXACT []
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
xref: Wikipedia:Ribonucleoprotein
is_a: GO:0032991 ! protein-containing complex
relationship: has_part CHEBI:33697 ! ribonucleic acid
created_by: pr
creation_date: 2015-11-19T12:26:37Z

[Term]
id: GO:1990917
name: ooplasm
namespace: cellular_component
def: "The cytoplasm of an ovum." [PMID:19022436]
is_a: GO:0005737 ! cytoplasm
intersection_of: GO:0005737 ! cytoplasm
intersection_of: part_of CL:0000025 ! egg cell
relationship: part_of CL:0000025 ! egg cell
property_value: RO:0002161 NCBITaxon:4751
created_by: sl
creation_date: 2015-12-10T21:40:16Z

[Term]
id: GO:2000018
name: regulation of male gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "regulation of testicular development" EXACT [GOC:obol]
synonym: "regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905939 ! regulation of gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008584 ! male gonad development
relationship: regulates GO:0008584 ! male gonad development
created_by: jl
creation_date: 2010-07-15T03:29:05Z

[Term]
id: GO:2000019
name: negative regulation of male gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of testicular development" EXACT [GOC:obol]
synonym: "negative regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905940 ! negative regulation of gonad development
is_a: GO:2000018 ! regulation of male gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008584 ! male gonad development
relationship: negatively_regulates GO:0008584 ! male gonad development
created_by: jl
creation_date: 2010-07-15T03:29:10Z

[Term]
id: GO:2000020
name: positive regulation of male gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol]
synonym: "positive regulation of testicular development" EXACT [GOC:obol]
synonym: "positive regulation of testis development" EXACT [GOC:obol]
is_a: GO:1905941 ! positive regulation of gonad development
is_a: GO:2000018 ! regulation of male gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008584 ! male gonad development
relationship: positively_regulates GO:0008584 ! male gonad development
created_by: jl
creation_date: 2010-07-15T03:29:13Z

[Term]
id: GO:2000026
name: regulation of multicellular organismal development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007275 ! multicellular organism development
relationship: regulates GO:0007275 ! multicellular organism development
created_by: tb
creation_date: 2010-08-05T11:25:59Z

[Term]
id: GO:2000027
name: regulation of animal organ morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol]
synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009887 ! animal organ morphogenesis
relationship: regulates GO:0009887 ! animal organ morphogenesis
created_by: tb
creation_date: 2010-08-05T11:26:27Z

[Term]
id: GO:2000035
name: regulation of stem cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol]
synonym: "regulation of stem cell renewal" EXACT [GOC:obol]
is_a: GO:0051302 ! regulation of cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0017145 ! stem cell division
relationship: regulates GO:0017145 ! stem cell division
created_by: tb
creation_date: 2010-08-05T11:34:53Z

[Term]
id: GO:2000036
name: regulation of stem cell population maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]
synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019827 ! stem cell population maintenance
relationship: regulates GO:0019827 ! stem cell population maintenance
created_by: tb
creation_date: 2010-08-05T11:35:25Z

[Term]
id: GO:2000061
name: regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jl
creation_date: 2010-08-20T01:44:16Z

[Term]
id: GO:2000062
name: negative regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jl
creation_date: 2010-08-20T01:44:23Z

[Term]
id: GO:2000063
name: positive regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation
created_by: jl
creation_date: 2010-08-20T01:44:28Z

[Term]
id: GO:2000068
name: regulation of defense response to insect
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol]
synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol]
is_a: GO:0031347 ! regulation of defense response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002213 ! defense response to insect
relationship: regulates GO:0002213 ! defense response to insect
created_by: tb
creation_date: 2010-08-23T09:30:00Z

[Term]
id: GO:2000074
name: regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0060284 ! regulation of cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003323 ! type B pancreatic cell development
relationship: regulates GO:0003323 ! type B pancreatic cell development
created_by: tb
creation_date: 2010-08-27T11:19:37Z

[Term]
id: GO:2000077
name: negative regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003323 ! type B pancreatic cell development
relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development
created_by: tb
creation_date: 2010-08-27T11:21:17Z

[Term]
id: GO:2000078
name: positive regulation of type B pancreatic cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]
synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah]
synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000074 ! regulation of type B pancreatic cell development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003323 ! type B pancreatic cell development
relationship: positively_regulates GO:0003323 ! type B pancreatic cell development
created_by: tb
creation_date: 2010-08-27T11:21:19Z

[Term]
id: GO:2000084
name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:06:41Z

[Term]
id: GO:2000085
name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:08:21Z

[Term]
id: GO:2000086
name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol]
is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis
created_by: dph
creation_date: 2010-09-03T06:08:24Z

[Term]
id: GO:2000106
name: regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "regulation of leukocyte apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071887 ! leukocyte apoptotic process
relationship: regulates GO:0071887 ! leukocyte apoptotic process
created_by: mah
creation_date: 2010-09-15T01:42:05Z

[Term]
id: GO:2000107
name: negative regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "negative regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071887 ! leukocyte apoptotic process
relationship: negatively_regulates GO:0071887 ! leukocyte apoptotic process
created_by: mah
creation_date: 2010-09-15T01:42:09Z

[Term]
id: GO:2000108
name: positive regulation of leukocyte apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]
synonym: "positive regulation of leukocyte apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071887 ! leukocyte apoptotic process
relationship: positively_regulates GO:0071887 ! leukocyte apoptotic process
created_by: mah
creation_date: 2010-09-15T01:42:12Z

[Term]
id: GO:2000114
name: regulation of establishment of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph]
synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol]
synonym: "regulation of cell polarization" EXACT [GOC:obol]
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030010 ! establishment of cell polarity
relationship: regulates GO:0030010 ! establishment of cell polarity
created_by: dph
creation_date: 2010-09-16T01:22:36Z

[Term]
id: GO:2000136
name: regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:53Z

[Term]
id: GO:2000137
name: negative regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:55Z

[Term]
id: GO:2000138
name: positive regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis
created_by: dph
creation_date: 2010-09-29T12:43:57Z

[Term]
id: GO:2000145
name: regulation of cell motility
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "regulation of cell locomotion" EXACT [GOC:obol]
synonym: "regulation of cell movement" RELATED [GOC:obol]
synonym: "regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050794 ! regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048870 ! cell motility
relationship: regulates GO:0048870 ! cell motility
created_by: mah
creation_date: 2010-10-01T09:41:21Z

[Term]
id: GO:2000146
name: negative regulation of cell motility
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "negative regulation of cell locomotion" EXACT [GOC:obol]
synonym: "negative regulation of cell movement" RELATED [GOC:obol]
synonym: "negative regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048870 ! cell motility
relationship: negatively_regulates GO:0048870 ! cell motility
created_by: mah
creation_date: 2010-10-01T09:41:26Z

[Term]
id: GO:2000147
name: positive regulation of cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]
synonym: "positive regulation of cell locomotion" EXACT [GOC:obol]
synonym: "positive regulation of cell movement" RELATED [GOC:obol]
synonym: "positive regulation of movement of a cell" EXACT [GOC:obol]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:2000145 ! regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048870 ! cell motility
relationship: positively_regulates GO:0048870 ! cell motility
created_by: mah
creation_date: 2010-10-01T09:41:30Z

[Term]
id: GO:2000155
name: positive regulation of cilium-dependent cell motility
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl]
synonym: "positive regulation of ciliary cell motility" RELATED []
is_a: GO:1902019 ! regulation of cilium-dependent cell motility
is_a: GO:2000147 ! positive regulation of cell motility
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060285 ! cilium-dependent cell motility
relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility
created_by: mah
creation_date: 2010-10-04T12:41:05Z

[Term]
id: GO:2000172
name: regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048755 ! branching morphogenesis of a nerve
relationship: regulates GO:0048755 ! branching morphogenesis of a nerve
created_by: rl
creation_date: 2010-10-07T12:07:54Z

[Term]
id: GO:2000173
name: negative regulation of branching morphogenesis of a nerve
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve
relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve
created_by: rl
creation_date: 2010-10-07T12:07:56Z

[Term]
id: GO:2000174
name: regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002572 ! pro-T cell differentiation
relationship: regulates GO:0002572 ! pro-T cell differentiation
created_by: mah
creation_date: 2010-10-11T10:24:30Z

[Term]
id: GO:2000175
name: negative regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002572 ! pro-T cell differentiation
relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation
created_by: mah
creation_date: 2010-10-11T10:24:33Z

[Term]
id: GO:2000176
name: positive regulation of pro-T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]
synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol]
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation
is_a: GO:2000174 ! regulation of pro-T cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002572 ! pro-T cell differentiation
relationship: positively_regulates GO:0002572 ! pro-T cell differentiation
created_by: mah
creation_date: 2010-10-11T10:24:35Z

[Term]
id: GO:2000177
name: regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061351 ! neural precursor cell proliferation
relationship: regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:41Z

[Term]
id: GO:2000178
name: negative regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061351 ! neural precursor cell proliferation
relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:43Z

[Term]
id: GO:2000179
name: positive regulation of neural precursor cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000177 ! regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061351 ! neural precursor cell proliferation
relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation
created_by: dph
creation_date: 2010-10-13T12:40:45Z

[Term]
id: GO:2000181
name: negative regulation of blood vessel morphogenesis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:1901343 ! negative regulation of vasculature development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048514 ! blood vessel morphogenesis
relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis
created_by: dph
creation_date: 2010-10-13T12:46:31Z

[Term]
id: GO:2000185
name: regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "regulation of phosphate membrane transport" EXACT []
is_a: GO:0010966 ! regulation of phosphate transport
is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:04Z

[Term]
id: GO:2000186
name: negative regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "negative regulation of phosphate membrane transport" EXACT []
is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:08Z

[Term]
id: GO:2000187
name: positive regulation of phosphate transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]
synonym: "positive regulation of phosphate membrane transport" EXACT []
is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport
is_a: GO:2000185 ! regulation of phosphate transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035435 ! phosphate ion transmembrane transport
relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport
created_by: vw
creation_date: 2010-10-15T11:33:10Z

[Term]
id: GO:2000194
name: regulation of female gonad development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "regulation of ovarian development" EXACT [GOC:obol]
synonym: "regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905939 ! regulation of gonad development
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008585 ! female gonad development
relationship: regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:34Z

[Term]
id: GO:2000195
name: negative regulation of female gonad development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "negative regulation of ovarian development" EXACT [GOC:obol]
synonym: "negative regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905940 ! negative regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008585 ! female gonad development
relationship: negatively_regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:38Z

[Term]
id: GO:2000196
name: positive regulation of female gonad development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol]
synonym: "positive regulation of ovarian development" EXACT [GOC:obol]
synonym: "positive regulation of ovary development" EXACT [GOC:obol]
is_a: GO:1905941 ! positive regulation of gonad development
is_a: GO:2000194 ! regulation of female gonad development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008585 ! female gonad development
relationship: positively_regulates GO:0008585 ! female gonad development
created_by: yaf
creation_date: 2010-10-19T10:45:41Z

[Term]
id: GO:2000226
name: regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003310 ! pancreatic A cell differentiation
relationship: regulates GO:0003310 ! pancreatic A cell differentiation
created_by: mah
creation_date: 2010-11-09T03:43:37Z

[Term]
id: GO:2000227
name: negative regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003310 ! pancreatic A cell differentiation
relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation
created_by: mah
creation_date: 2010-11-09T03:43:40Z

[Term]
id: GO:2000228
name: positive regulation of pancreatic A cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]
synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000226 ! regulation of pancreatic A cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003310 ! pancreatic A cell differentiation
relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation
created_by: mah
creation_date: 2010-11-09T03:43:42Z

[Term]
id: GO:2000241
name: regulation of reproductive process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0022414 ! reproductive process
relationship: regulates GO:0022414 ! reproductive process
created_by: mah
creation_date: 2010-11-10T02:44:02Z

[Term]
id: GO:2000242
name: negative regulation of reproductive process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0022414 ! reproductive process
relationship: negatively_regulates GO:0022414 ! reproductive process
created_by: mah
creation_date: 2010-11-10T02:44:05Z

[Term]
id: GO:2000243
name: positive regulation of reproductive process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:2000241 ! regulation of reproductive process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0022414 ! reproductive process
relationship: positively_regulates GO:0022414 ! reproductive process
created_by: mah
creation_date: 2010-11-10T02:44:08Z

[Term]
id: GO:2000248
name: negative regulation of establishment or maintenance of neuroblast polarity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol]
synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0045769 ! negative regulation of asymmetric cell division
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity
relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity
created_by: vw
creation_date: 2010-11-11T11:40:34Z

[Term]
id: GO:2000254
name: regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905936 ! regulation of germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002176 ! male germ cell proliferation
relationship: regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:44Z

[Term]
id: GO:2000255
name: negative regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905937 ! negative regulation of germ cell proliferation
is_a: GO:2000254 ! regulation of male germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002176 ! male germ cell proliferation
relationship: negatively_regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:47Z

[Term]
id: GO:2000256
name: positive regulation of male germ cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol]
is_a: GO:1905938 ! positive regulation of germ cell proliferation
is_a: GO:2000254 ! regulation of male germ cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002176 ! male germ cell proliferation
relationship: positively_regulates GO:0002176 ! male germ cell proliferation
created_by: dph
creation_date: 2010-11-18T09:29:50Z

[Term]
id: GO:2000269
name: regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "regulation of fibroblast apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0044346 ! fibroblast apoptotic process
relationship: regulates GO:0044346 ! fibroblast apoptotic process
created_by: jl
creation_date: 2010-11-23T01:07:23Z

[Term]
id: GO:2000270
name: negative regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "negative regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0044346 ! fibroblast apoptotic process
relationship: negatively_regulates GO:0044346 ! fibroblast apoptotic process
created_by: jl
creation_date: 2010-11-23T01:07:27Z

[Term]
id: GO:2000271
name: positive regulation of fibroblast apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]
synonym: "positive regulation of fibroblast apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2000269 ! regulation of fibroblast apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0044346 ! fibroblast apoptotic process
relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process
created_by: jl
creation_date: 2010-11-23T01:07:29Z

[Term]
id: GO:2000278
name: regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of DNA formation" EXACT [GOC:obol]
synonym: "regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0071897 ! DNA biosynthetic process
relationship: regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2010-12-08T04:48:15Z

[Term]
id: GO:2000279
name: negative regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of DNA formation" EXACT [GOC:obol]
synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0071897 ! DNA biosynthetic process
relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2010-12-08T04:48:20Z

[Term]
id: GO:2000282
name: regulation of cellular amino acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol]
synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0062012 ! regulation of small molecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0008652 ! amino acid biosynthetic process
relationship: regulates GO:0008652 ! amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:19Z

[Term]
id: GO:2000283
name: negative regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process." [GOC:obol]
synonym: "negative regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "negative regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "negative regulation of amino acid formation" EXACT [GOC:obol]
synonym: "negative regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "negative regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0062014 ! negative regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0008652 ! amino acid biosynthetic process
relationship: negatively_regulates GO:0008652 ! amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:23Z

[Term]
id: GO:2000284
name: positive regulation of amino acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]
synonym: "positive regulation of amino acid anabolism" EXACT [GOC:obol]
synonym: "positive regulation of amino acid biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of amino acid formation" EXACT [GOC:obol]
synonym: "positive regulation of amino acid synthesis" EXACT [GOC:obol]
synonym: "positive regulation of cellular amino acid biosynthetic process" EXACT [GOC:obol]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0062013 ! positive regulation of small molecule metabolic process
is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0008652 ! amino acid biosynthetic process
relationship: positively_regulates GO:0008652 ! amino acid biosynthetic process
created_by: vw
creation_date: 2010-12-10T11:54:27Z

[Term]
id: GO:2000287
name: positive regulation of myotome development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000290 ! regulation of myotome development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061055 ! myotome development
relationship: positively_regulates GO:0061055 ! myotome development
created_by: rl
creation_date: 2010-12-16T05:17:15Z

[Term]
id: GO:2000288
name: positive regulation of myoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051450 ! myoblast proliferation
relationship: positively_regulates GO:0051450 ! myoblast proliferation
created_by: rl
creation_date: 2010-12-16T05:20:52Z

[Term]
id: GO:2000290
name: regulation of myotome development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061055 ! myotome development
relationship: regulates GO:0061055 ! myotome development
created_by: mah
creation_date: 2010-12-20T10:22:05Z

[Term]
id: GO:2000291
name: regulation of myoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051450 ! myoblast proliferation
relationship: regulates GO:0051450 ! myoblast proliferation
created_by: mah
creation_date: 2010-12-20T10:34:26Z

[Term]
id: GO:2000292
name: regulation of defecation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0044062 ! regulation of excretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030421 ! defecation
relationship: regulates GO:0030421 ! defecation
created_by: bf
creation_date: 2010-12-21T09:23:08Z

[Term]
id: GO:2000293
name: negative regulation of defecation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:2000292 ! regulation of defecation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030421 ! defecation
relationship: negatively_regulates GO:0030421 ! defecation
created_by: bf
creation_date: 2010-12-21T09:23:13Z

[Term]
id: GO:2000294
name: positive regulation of defecation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:2000292 ! regulation of defecation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030421 ! defecation
relationship: positively_regulates GO:0030421 ! defecation
created_by: bf
creation_date: 2010-12-21T09:23:16Z

[Term]
id: GO:2000351
name: regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]
synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of endothelial cell apoptosis" NARROW []
synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072577 ! endothelial cell apoptotic process
relationship: regulates GO:0072577 ! endothelial cell apoptotic process
created_by: mah
creation_date: 2011-02-03T10:43:16Z

[Term]
id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of endothelial cell apoptosis" NARROW []
synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072577 ! endothelial cell apoptotic process
relationship: negatively_regulates GO:0072577 ! endothelial cell apoptotic process
created_by: mah
creation_date: 2011-02-03T10:43:20Z

[Term]
id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]
synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of endothelial cell apoptosis" NARROW []
synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol]
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:2000351 ! regulation of endothelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072577 ! endothelial cell apoptotic process
relationship: positively_regulates GO:0072577 ! endothelial cell apoptotic process
created_by: mah
creation_date: 2011-02-03T10:43:23Z

[Term]
id: GO:2000374
name: regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031323 ! regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072592 ! oxygen metabolic process
relationship: regulates GO:0072592 ! oxygen metabolic process
created_by: mah
creation_date: 2011-02-11T02:03:32Z

[Term]
id: GO:2000375
name: negative regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072592 ! oxygen metabolic process
relationship: negatively_regulates GO:0072592 ! oxygen metabolic process
created_by: mah
creation_date: 2011-02-11T02:03:44Z

[Term]
id: GO:2000376
name: positive regulation of oxygen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah]
synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol]
synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:2000374 ! regulation of oxygen metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072592 ! oxygen metabolic process
relationship: positively_regulates GO:0072592 ! oxygen metabolic process
created_by: mah
creation_date: 2011-02-11T02:03:52Z

[Term]
id: GO:2000380
name: regulation of mesoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007498 ! mesoderm development
relationship: regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:09:46Z

[Term]
id: GO:2000381
name: negative regulation of mesoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007498 ! mesoderm development
relationship: negatively_regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:10:02Z

[Term]
id: GO:2000382
name: positive regulation of mesoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000380 ! regulation of mesoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007498 ! mesoderm development
relationship: positively_regulates GO:0007498 ! mesoderm development
created_by: vk
creation_date: 2011-02-15T03:10:12Z

[Term]
id: GO:2000383
name: regulation of ectoderm development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0050793 ! regulation of developmental process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007398 ! ectoderm development
relationship: regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:10Z

[Term]
id: GO:2000384
name: negative regulation of ectoderm development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007398 ! ectoderm development
relationship: negatively_regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:27Z

[Term]
id: GO:2000385
name: positive regulation of ectoderm development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:2000383 ! regulation of ectoderm development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007398 ! ectoderm development
relationship: positively_regulates GO:0007398 ! ectoderm development
created_by: vk
creation_date: 2011-02-15T03:17:39Z

[Term]
id: GO:2000401
name: regulation of lymphocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071675 ! regulation of mononuclear cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072676 ! lymphocyte migration
relationship: regulates GO:0072676 ! lymphocyte migration
created_by: mah
creation_date: 2011-02-23T10:45:19Z

[Term]
id: GO:2000402
name: negative regulation of lymphocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071676 ! negative regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072676 ! lymphocyte migration
relationship: negatively_regulates GO:0072676 ! lymphocyte migration
created_by: mah
creation_date: 2011-02-23T10:45:47Z

[Term]
id: GO:2000403
name: positive regulation of lymphocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah]
is_a: GO:0071677 ! positive regulation of mononuclear cell migration
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072676 ! lymphocyte migration
relationship: positively_regulates GO:0072676 ! lymphocyte migration
created_by: mah
creation_date: 2011-02-23T10:46:06Z

[Term]
id: GO:2000404
name: regulation of T cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "regulation of T-cell migration" EXACT [GOC:obol]
synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000401 ! regulation of lymphocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0072678 ! T cell migration
relationship: regulates GO:0072678 ! T cell migration
created_by: mah
creation_date: 2011-02-23T10:48:24Z

[Term]
id: GO:2000405
name: negative regulation of T cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "negative regulation of T-cell migration" EXACT [GOC:obol]
synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000402 ! negative regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072678 ! T cell migration
relationship: negatively_regulates GO:0072678 ! T cell migration
created_by: mah
creation_date: 2011-02-23T10:48:52Z

[Term]
id: GO:2000406
name: positive regulation of T cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah]
synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol]
synonym: "positive regulation of T-cell migration" EXACT [GOC:obol]
synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol]
is_a: GO:2000403 ! positive regulation of lymphocyte migration
is_a: GO:2000404 ! regulation of T cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072678 ! T cell migration
relationship: positively_regulates GO:0072678 ! T cell migration
created_by: mah
creation_date: 2011-02-23T10:49:12Z

[Term]
id: GO:2000471
name: regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035701 ! hematopoietic stem cell migration
relationship: regulates GO:0035701 ! hematopoietic stem cell migration
created_by: bf
creation_date: 2011-03-09T09:34:08Z

[Term]
id: GO:2000472
name: negative regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035701 ! hematopoietic stem cell migration
relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration
created_by: bf
creation_date: 2011-03-09T09:34:54Z

[Term]
id: GO:2000473
name: positive regulation of hematopoietic stem cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]
synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2000471 ! regulation of hematopoietic stem cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035701 ! hematopoietic stem cell migration
relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration
created_by: bf
creation_date: 2011-03-09T09:35:25Z

[Term]
id: GO:2000495
name: regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0042127 ! regulation of cell population proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: bf
creation_date: 2011-03-18T02:18:34Z

[Term]
id: GO:2000496
name: negative regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: bf
creation_date: 2011-03-18T02:19:22Z

[Term]
id: GO:2000497
name: positive regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis
created_by: bf
creation_date: 2011-03-18T02:19:54Z

[Term]
id: GO:2000542
name: negative regulation of gastrulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0045992 ! negative regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007369 ! gastrulation
relationship: negatively_regulates GO:0007369 ! gastrulation
created_by: yaf
creation_date: 2011-04-01T04:10:08Z

[Term]
id: GO:2000543
name: positive regulation of gastrulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0040019 ! positive regulation of embryonic development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007369 ! gastrulation
relationship: positively_regulates GO:0007369 ! gastrulation
created_by: yaf
creation_date: 2011-04-01T04:10:15Z

[Term]
id: GO:2000547
name: regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:21:55Z

[Term]
id: GO:2000548
name: negative regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "negative regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:22:01Z

[Term]
id: GO:2000549
name: positive regulation of dendritic cell dendrite assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]
synonym: "positive regulation of dendritic extension" RELATED [GOC:obol]
is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly
is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097026 ! dendritic cell dendrite assembly
relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly
created_by: ebc
creation_date: 2011-04-03T07:22:06Z

[Term]
id: GO:2000573
name: positive regulation of DNA biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]
synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol]
synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol]
synonym: "positive regulation of DNA formation" EXACT [GOC:obol]
synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:2000278 ! regulation of DNA biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process
relationship: positively_regulates GO:0071897 ! DNA biosynthetic process
created_by: yaf
creation_date: 2011-04-04T10:01:20Z

[Term]
id: GO:2000606
name: regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:19Z

[Term]
id: GO:2000607
name: negative regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:23Z

[Term]
id: GO:2000608
name: positive regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]
is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development
is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development
created_by: yaf
creation_date: 2011-04-18T08:42:25Z

[Term]
id: GO:2000647
name: negative regulation of stem cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0072089 ! stem cell proliferation
relationship: negatively_regulates GO:0072089 ! stem cell proliferation
created_by: dph
creation_date: 2011-04-27T01:04:22Z

[Term]
id: GO:2000648
name: positive regulation of stem cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph]
is_a: GO:0008284 ! positive regulation of cell population proliferation
is_a: GO:0072091 ! regulation of stem cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072089 ! stem cell proliferation
relationship: positively_regulates GO:0072089 ! stem cell proliferation
created_by: dph
creation_date: 2011-04-27T01:04:25Z

[Term]
id: GO:2000649
name: regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_do_not_annotate
synonym: "regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032412 ! regulation of monoatomic ion transmembrane transporter activity
is_a: GO:1902305 ! regulation of sodium ion transmembrane transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:42:53Z

[Term]
id: GO:2000650
name: negative regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_do_not_annotate
synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: negatively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:42:57Z

[Term]
id: GO:2000651
name: positive regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]
subset: gocheck_do_not_annotate
synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport
is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
relationship: positively_regulates GO:0015081 ! sodium ion transmembrane transporter activity
created_by: yaf
creation_date: 2011-04-28T08:43:00Z

[Term]
id: GO:2000668
name: regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000106 ! regulation of leukocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097048 ! dendritic cell apoptotic process
relationship: regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:16Z

[Term]
id: GO:2000669
name: negative regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097048 ! dendritic cell apoptotic process
relationship: negatively_regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:21Z

[Term]
id: GO:2000670
name: positive regulation of dendritic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of dendritic cell apoptosis" NARROW []
is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process
is_a: GO:2000668 ! regulation of dendritic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097048 ! dendritic cell apoptotic process
relationship: positively_regulates GO:0097048 ! dendritic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T07:34:26Z

[Term]
id: GO:2000671
name: regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043523 ! regulation of neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097049 ! motor neuron apoptotic process
relationship: regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:17Z

[Term]
id: GO:2000672
name: negative regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043524 ! negative regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097049 ! motor neuron apoptotic process
relationship: negatively_regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:21Z

[Term]
id: GO:2000673
name: positive regulation of motor neuron apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of motor neuron apoptosis" NARROW []
is_a: GO:0043525 ! positive regulation of neuron apoptotic process
is_a: GO:2000671 ! regulation of motor neuron apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097049 ! motor neuron apoptotic process
relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process
created_by: pr
creation_date: 2011-05-09T10:56:24Z

[Term]
id: GO:2000674
name: regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904035 ! regulation of epithelial cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:09Z

[Term]
id: GO:2000675
name: negative regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:12Z

[Term]
id: GO:2000676
name: positive regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol]
synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW []
is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process
is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process
created_by: pr
creation_date: 2011-05-09T11:51:15Z

[Term]
id: GO:2000690
name: regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:01Z

[Term]
id: GO:2000691
name: negative regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045662 ! negative regulation of myoblast differentiation
is_a: GO:0051892 ! negative regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:06Z

[Term]
id: GO:2000696
name: regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: bf
creation_date: 2011-05-16T04:23:52Z

[Term]
id: GO:2000697
name: negative regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: bf
creation_date: 2011-05-16T04:23:55Z

[Term]
id: GO:2000698
name: positive regulation of epithelial cell differentiation involved in kidney development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf]
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development
created_by: bf
creation_date: 2011-05-16T04:23:57Z

[Term]
id: GO:2000700
name: positive regulation of cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol]
synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol]
synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol]
is_a: GO:0045663 ! positive regulation of myoblast differentiation
is_a: GO:0051891 ! positive regulation of cardioblast differentiation
is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: yaf
creation_date: 2011-05-25T09:08:09Z

[Term]
id: GO:2000725
name: regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:1905207 ! regulation of cardiocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:06Z

[Term]
id: GO:2000726
name: negative regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:1905208 ! negative regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:11Z

[Term]
id: GO:2000727
name: positive regulation of cardiac muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF]
synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol]
synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol]
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:1905209 ! positive regulation of cardiocyte differentiation
is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0055007 ! cardiac muscle cell differentiation
relationship: positively_regulates GO:0055007 ! cardiac muscle cell differentiation
created_by: vk
creation_date: 2011-06-08T10:51:15Z

[Term]
id: GO:2000729
name: positive regulation of mesenchymal cell proliferation involved in ureter development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol]
synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol]
synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
relationship: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development
created_by: yaf
creation_date: 2011-06-10T02:27:19Z

[Term]
id: GO:2000736
name: regulation of stem cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048863 ! stem cell differentiation
relationship: regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:16Z

[Term]
id: GO:2000737
name: negative regulation of stem cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048863 ! stem cell differentiation
relationship: negatively_regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:20Z

[Term]
id: GO:2000738
name: positive regulation of stem cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2000736 ! regulation of stem cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048863 ! stem cell differentiation
relationship: positively_regulates GO:0048863 ! stem cell differentiation
created_by: yaf
creation_date: 2011-06-14T02:05:23Z

[Term]
id: GO:2000768
name: positive regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol]
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation
created_by: yaf
creation_date: 2011-06-22T11:55:06Z

[Term]
id: GO:2000790
name: regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:50Z

[Term]
id: GO:2000791
name: negative regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:53Z

[Term]
id: GO:2000792
name: positive regulation of mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
relationship: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development
created_by: pr
creation_date: 2011-06-24T01:53:56Z

[Term]
id: GO:2000794
name: regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
created_by: pr
creation_date: 2011-06-25T07:22:38Z

[Term]
id: GO:2000795
name: negative regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
created_by: pr
creation_date: 2011-06-25T07:22:42Z

[Term]
id: GO:2000818
name: negative regulation of myoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol]
is_a: GO:0008285 ! negative regulation of cell population proliferation
is_a: GO:2000291 ! regulation of myoblast proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051450 ! myoblast proliferation
relationship: negatively_regulates GO:0051450 ! myoblast proliferation
created_by: pr
creation_date: 2011-07-12T03:06:04Z

[Term]
id: GO:2000826
name: regulation of heart morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF]
synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol]
is_a: GO:2000027 ! regulation of animal organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003007 ! heart morphogenesis
relationship: regulates GO:0003007 ! heart morphogenesis
created_by: vk
creation_date: 2011-07-19T10:08:58Z

[Term]
id: GO:2000831
name: regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035929 ! steroid hormone secretion
relationship: regulates GO:0035929 ! steroid hormone secretion
created_by: bf
creation_date: 2011-07-26T08:38:46Z

[Term]
id: GO:2000832
name: negative regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035929 ! steroid hormone secretion
relationship: negatively_regulates GO:0035929 ! steroid hormone secretion
created_by: bf
creation_date: 2011-07-26T08:38:50Z

[Term]
id: GO:2000833
name: positive regulation of steroid hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl]
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035929 ! steroid hormone secretion
relationship: positively_regulates GO:0035929 ! steroid hormone secretion
created_by: bf
creation_date: 2011-07-26T08:38:51Z

[Term]
id: GO:2000834
name: regulation of androgen secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000831 ! regulation of steroid hormone secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035935 ! androgen secretion
relationship: regulates GO:0035935 ! androgen secretion
created_by: bf
creation_date: 2011-07-26T08:39:45Z

[Term]
id: GO:2000835
name: negative regulation of androgen secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000832 ! negative regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035935 ! androgen secretion
relationship: negatively_regulates GO:0035935 ! androgen secretion
created_by: bf
creation_date: 2011-07-26T08:39:48Z

[Term]
id: GO:2000836
name: positive regulation of androgen secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl]
is_a: GO:2000833 ! positive regulation of steroid hormone secretion
is_a: GO:2000834 ! regulation of androgen secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035935 ! androgen secretion
relationship: positively_regulates GO:0035935 ! androgen secretion
created_by: bf
creation_date: 2011-07-26T08:39:51Z

[Term]
id: GO:2001012
name: mesenchymal cell differentiation involved in renal system development
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]
synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol]
synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol]
is_a: GO:0048762 ! mesenchymal cell differentiation
intersection_of: GO:0048762 ! mesenchymal cell differentiation
intersection_of: part_of GO:0072001 ! renal system development
relationship: part_of GO:0072001 ! renal system development
created_by: yaf
creation_date: 2011-08-09T04:05:14Z

[Term]
id: GO:2001013
name: epithelial cell proliferation involved in renal tubule morphogenesis
namespace: biological_process
def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol]
is_a: GO:0050673 ! epithelial cell proliferation
intersection_of: GO:0050673 ! epithelial cell proliferation
intersection_of: part_of GO:0061333 ! renal tubule morphogenesis
relationship: part_of GO:0061333 ! renal tubule morphogenesis
created_by: yaf
creation_date: 2011-08-12T11:37:29Z

[Term]
id: GO:2001014
name: regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:37Z

[Term]
id: GO:2001015
name: negative regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:41Z

[Term]
id: GO:2001016
name: positive regulation of skeletal muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0035914 ! skeletal muscle cell differentiation
relationship: positively_regulates GO:0035914 ! skeletal muscle cell differentiation
created_by: yaf
creation_date: 2011-08-11T08:54:44Z

[Term]
id: GO:2001053
name: regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:49:59Z

[Term]
id: GO:2001054
name: negative regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "negative regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:50:05Z

[Term]
id: GO:2001055
name: positive regulation of mesenchymal cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]
synonym: "positive regulation of mesenchymal cell apoptosis" NARROW []
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process
relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process
created_by: yaf
creation_date: 2011-09-08T02:50:09Z

[Term]
id: GO:2001141
name: regulation of RNA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph]
synonym: "regulation of RNA anabolism" EXACT [GOC:obol]
synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol]
synonym: "regulation of RNA formation" EXACT [GOC:obol]
synonym: "regulation of RNA synthesis" EXACT [GOC:obol]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0032774 ! RNA biosynthetic process
relationship: regulates GO:0032774 ! RNA biosynthetic process
created_by: dph
creation_date: 2011-10-17T11:36:25Z

[Term]
id: GO:2001198
name: regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902105 ! regulation of leukocyte differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097028 ! dendritic cell differentiation
relationship: regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:27Z

[Term]
id: GO:2001199
name: negative regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902106 ! negative regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097028 ! dendritic cell differentiation
relationship: negatively_regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:33Z

[Term]
id: GO:2001200
name: positive regulation of dendritic cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol]
is_a: GO:1902107 ! positive regulation of leukocyte differentiation
is_a: GO:2001198 ! regulation of dendritic cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097028 ! dendritic cell differentiation
relationship: positively_regulates GO:0097028 ! dendritic cell differentiation
created_by: yaf
creation_date: 2011-11-04T02:01:36Z

[Term]
id: GO:2001212
name: regulation of vasculogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045595 ! regulation of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001570 ! vasculogenesis
relationship: regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:31Z

[Term]
id: GO:2001213
name: negative regulation of vasculogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:2001212 ! regulation of vasculogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001570 ! vasculogenesis
relationship: negatively_regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:36Z

[Term]
id: GO:2001214
name: positive regulation of vasculogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol]
synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:2001212 ! regulation of vasculogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001570 ! vasculogenesis
relationship: positively_regulates GO:0001570 ! vasculogenesis
created_by: yaf
creation_date: 2011-11-15T01:22:39Z

[Term]
id: GO:2001222
name: regulation of neuron migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "regulation of neuron guidance" RELATED [GOC:obol]
synonym: "regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001764 ! neuron migration
relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
relationship: regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:38Z

[Term]
id: GO:2001223
name: negative regulation of neuron migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "negative regulation of neuron guidance" RELATED [GOC:obol]
synonym: "negative regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001764 ! neuron migration
relationship: negatively_regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:45Z

[Term]
id: GO:2001224
name: positive regulation of neuron migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol]
synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol]
synonym: "positive regulation of neuron guidance" RELATED [GOC:obol]
synonym: "positive regulation of neuronal migration" EXACT [GOC:obol]
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:2001222 ! regulation of neuron migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001764 ! neuron migration
relationship: positively_regulates GO:0001764 ! neuron migration
created_by: kmv
creation_date: 2011-11-17T10:01:49Z

[Term]
id: GO:2001233
name: regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0042981 ! regulation of apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0097190 ! apoptotic signaling pathway
relationship: regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:49Z

[Term]
id: GO:2001234
name: negative regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043066 ! negative regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0097190 ! apoptotic signaling pathway
relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:54Z

[Term]
id: GO:2001235
name: positive regulation of apoptotic signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]
synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043065 ! positive regulation of apoptotic process
is_a: GO:2001233 ! regulation of apoptotic signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0097190 ! apoptotic signaling pathway
relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway
created_by: pr
creation_date: 2011-11-24T01:20:58Z

[Term]
id: GO:2001251
name: negative regulation of chromosome organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0051276 ! chromosome organization
relationship: negatively_regulates GO:0051276 ! chromosome organization
created_by: yaf
creation_date: 2011-12-02T02:01:20Z

[Term]
id: GO:2001252
name: positive regulation of chromosome organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]
synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol]
synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol]
synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol]
synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0051276 ! chromosome organization
relationship: positively_regulates GO:0051276 ! chromosome organization
created_by: yaf
creation_date: 2011-12-02T02:01:26Z

[Term]
id: IAO:0000027
name: data item
def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
is_a: IAO:0000030 ! information content entity
property_value: editor_note "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers." xsd:string
property_value: editor_note "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum." xsd:string
property_value: editor_note "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym." xsd:string
property_value: editor_note "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" xsd:string
property_value: editor_note "JAR: datum     -- well, this will be very tricky to define, but maybe some \ninformation-like stuff that might be put into a computer and that is \nmeant, by someone, to denote and/or to be interpreted by some \nprocess... I would include lists, tables, sentences... I think I might \ndefer to Barry, or to Brian Cantwell Smith\n\nJAR: A data item is an approximately justified approximately true approximate belief" xsd:string
property_value: IAO:0000111 "data item" xsd:string
property_value: IAO:0000112 "Data items include counts of things, analyte concentrations, and statistical summaries." xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string
property_value: IAO:0000118 "data" xsd:string

[Term]
id: IAO:0000028
name: symbol
def: "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity." []
is_a: IAO:0000030 ! information content entity
property_value: editor_note "20091104, MC: this needs work and will most probably change" xsd:string
property_value: editor_note "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)." xsd:string
property_value: IAO:0000111 "symbol" xsd:string
property_value: IAO:0000112 "a serial number such as \"12324X\"" xsd:string
property_value: IAO:0000112 "a stop sign" xsd:string
property_value: IAO:0000112 "a written proper name such as \"OBI\"" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON: James A. Overton" xsd:string
property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string
property_value: IAO:0000119 "based on Oxford English Dictionary" xsd:string

[Term]
id: IAO:0000030
name: information content entity
def: "A generically dependent continuant that is about some thing." []
is_a: BFO:0000031 ! generically dependent continuant
relationship: IAO:0000136 BFO:0000001 ! is about entity
property_value: editor_note "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)." xsd:string
property_value: editor_note "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).\n\nPrevious. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity." xsd:string
property_value: IAO:0000111 "information content entity" xsd:string
property_value: IAO:0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs." xsd:string
property_value: IAO:0000114 IAO:0000122
property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
property_value: IAO:0000119 "OBI_0000142" xsd:string

[Term]
id: IAO:0000078
name: curation status specification
def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
is_a: IAO:0000102 ! data about an ontology part
property_value: editor_note "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string
property_value: IAO:0000111 "curation status specification" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string
property_value: IAO:0000119 "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>" xsd:string
property_value: IAO:0000119 "OBI_0000266" xsd:string

[Term]
id: IAO:0000102
name: data about an ontology part
def: "Data about an ontology part is a data item about a part of an ontology, for example a term" []
is_a: IAO:0000027 ! data item
property_value: IAO:0000111 "data about an ontology part" xsd:string
property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string

[Term]
id: IAO:0000225
name: obsolescence reason specification
def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
is_a: IAO:0000102 ! data about an ontology part
property_value: editor_note "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string
property_value: IAO:0000111 "obsolescence reason specification" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string

[Term]
id: IAO:0000409
name: denotator type
def: "A denotator type indicates how a term should be interpreted from an ontological perspective." []
is_a: IAO:0000102 ! data about an ontology part
property_value: IAO:0000111 "denotator type" xsd:string
property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string
property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string

[Term]
id: IAO:0000577
name: centrally registered identifier symbol
def: "A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry." []
is_a: IAO:0000028 ! symbol
relationship: part_of IAO:0000578 ! centrally registered identifier
property_value: IAO:0000112 "The sentence \"The article has Pubmed ID 12345.\" contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed." xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bill Hogan" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string
property_value: IAO:0000118 "CRID symbol" xsd:string
property_value: IAO:0000119 "Original proposal from Bjoern, discussions at IAO calls" xsd:string

[Term]
id: IAO:0000578
name: centrally registered identifier
def: "An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs." []
is_a: IAO:0020000 ! identifier
relationship: has_part IAO:0000577 ! centrally registered identifier symbol
property_value: editor_note "2014-05-05: In defining this term we take no position on what the CRID denotes. In particular do not assume it denotes a *record* in the CRID registry (since the registry might not have 'records')." xsd:string
property_value: editor_note "Alan, IAO call 20101124: potentially the CRID denotes the instance it was associated with during creation." xsd:string
property_value: editor_note "Note, IAO call 20101124: URIs are not always CRID, as not centrally registered. We acknowledge that CRID is a subset of a larger identifier class, but this subset fulfills our current needs. OBI PURLs are CRID as they are registered with OCLC. UPCs (Universal Product Codes from AC Nielsen)are not CRID as they are not centrally registered." xsd:string
property_value: IAO:0000112 "The sentence \"The article has Pubmed ID 12345.\" contains a CRID that has two parts: one part is the CRID symbol, which is '12345'; the other part denotes the CRID registry, which is Pubmed." xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bill Hogan" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string
property_value: IAO:0000118 "CRID" xsd:string
property_value: IAO:0000119 "Original proposal from Bjoern, discussions at IAO calls" xsd:string

[Term]
id: IAO:0000579
name: centrally registered identifier registry
def: "A code set of CRID records, each consisting of a CRID symbol and additional information which was recorded in the code set through an assigning a centrally registered identifier process." []
is_a: IAO:0020020 ! code set
property_value: IAO:0000112 "PubMed is a CRID registry. It has a code set of PubMed identifiers associated with journal articles. " xsd:string
property_value: IAO:0000114 IAO:0000120
property_value: IAO:0000117 "Justin Whorton" xsd:string
property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "PERSON: Bill Hogan" xsd:string
property_value: IAO:0000117 "PERSON: Bjoern Peters" xsd:string
property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string
property_value: IAO:0000118 "CRID registry" xsd:string
property_value: IAO:0000119 "Original proposal from Bjoern, discussions at IAO calls" xsd:string
property_value: IAO:0000233 "https://github.com/information-artifact-ontology/IAO/issues/237" xsd:string

[Term]
id: IAO:0020000
name: identifier
def: "An information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity." []
comment: Sep 29, 2016: The current definition has been amended from the previous version: "A proper name is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity." to more accuratly reflect the necessary and sufficient condition on the class. (MB)
is_a: IAO:0000030 ! information content entity
intersection_of: IAO:0000030 ! information content entity
intersection_of: IAO:0000219 BFO:0000001 ! denotes entity
intersection_of: OBI:0000312 IAO:0020010 ! is_specified_output_of identifier creating process
relationship: IAO:0000219 BFO:0000001 ! denotes entity
relationship: OBI:0000312 IAO:0020010 ! is_specified_output_of identifier creating process
property_value: dc-creator "Mathias Brochhausen" xsd:string
property_value: IAO:0000111 "identifier" xsd:string
property_value: IAO:0000117 "Justin Whorton" xsd:string
property_value: IAO:0000117 "Mathias Brochhausen" xsd:string
property_value: IAO:0000118 "proper name" xsd:string
property_value: IAO:0000233 "https://github.com/information-artifact-ontology/IAO/issues/237" xsd:string

[Term]
id: IAO:0020010
name: identifier creating process
def: "A planned process that provides a reference to an individual entity shared by a group of subscribers to refer to that individual entity." []
is_a: OBI:0000011 ! planned process
intersection_of: OBI:0000011 ! planned process
intersection_of: OBI:0000299 IAO:0020000 ! has_specified_output identifier
relationship: OBI:0000299 IAO:0020000 ! has_specified_output identifier
property_value: dc-creator "Mathias Brochhausen" xsd:string
property_value: IAO:0000117 "Justin Whorton" xsd:string
property_value: IAO:0000117 "Mathias Brochhausen" xsd:string
property_value: IAO:0000118 "dubbing process" xsd:string
property_value: IAO:0000118 "naming" xsd:string
property_value: IAO:0000233 "https://github.com/information-artifact-ontology/IAO/issues/237" xsd:string

[Term]
id: IAO:0020020
name: code set
def: "An information content entity that is a collection of other information content entities that has been created to identify or annotate things in a specified domain, and where the intention of its creators is that the collection has a one-to-one correspondence with those things." []
comment: Code sets might include non-entities/things (e.g. missing thumbs).
comment: Does not imply absence vs. presence of any taxonomy.
comment: Does not imply that aggregated entities denote particulars, universals, or defined classes (a.k.a. attributive collections) or even that they denote only one of these three types of entities.
comment: Each aggregated entity is often (but not necessarily) associated with a text string—variously called a “description,” “name,” “title,” or “label”—that helps humans reach the target of denotation.\n\nWhen there is no such string, it is almost always because the entities take the form of human language words. For example, a “sex” or “gender” code set could contain “MALE” and “FEMALE,” or even “M” and “F” (by convention, we understand what these mean).
comment: For each given domain, there can potentially exist multiple code sets. The multiplicity of code sets is partially due to the different specific purposes of those code sets.
comment: For National Drug Codes (NDCs) and similar code sets, there doesn’t even have to be a single, fully-concretized copy somewhere (for example, for NDCs there is no centralized database or repository where they all live as one instance of concretization of code set). The code set can be “distributively” concretized. This seems like an unusual exception, but it also likely applies to Universal Product Codes (UPCs) and their follow on Global Trade Item Numbers (GTINs).
comment: Many code sets are created for a specific purpose in addition to merely identifying or annotating core ideas of a specified domain.
comment: The information content entities do not denote each other.
is_a: IAO:0000030 ! information content entity
relationship: has_part IAO:0020000 ! identifier
property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
property_value: IAO:0000117 "Justin Whorton" xsd:string
property_value: IAO:0000117 "Mathias Brochhausen" xsd:string
property_value: IAO:0000118 "code map" xsd:string
property_value: IAO:0000118 "code system" xsd:string
property_value: IAO:0000118 "codeset" xsd:string
property_value: IAO:0000118 "coding system" xsd:string
property_value: IAO:0000118 "controlled vocabulary" xsd:string
property_value: IAO:0000233 "https://github.com/information-artifact-ontology/IAO/issues/237" xsd:string
property_value: x_1.1:contributor "Alan Ruttenberg" xsd:string
property_value: x_1.1:contributor "Clint Dowland" xsd:string
property_value: x_1.1:contributor "Matt Diller" xsd:string
property_value: x_1.1:contributor "Sarah Bost" xsd:string
property_value: x_1.1:contributor "William R. Hogan" xsd:string

[Term]
id: NBO:0000001
name: body part movement
namespace: behavior_ontology
def: "A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]" []
synonym: "stationary movement" EXACT []
is_a: NBO:0000338 ! kinesthetic behavior
property_value: x_1.1:date "2011-04-14T01:03:39Z" xsd:string
created_by: George Gkoutos

[Term]
id: NBO:0000007
name: mouth movement
namespace: behavior_ontology
def: "The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]" []
synonym: "mouth part movement" NARROW []
synonym: "other moved mouth parts" NARROW []
is_a: NBO:0000001 ! body part movement
property_value: x_1.1:date "2011-04-14T01:03:39Z" xsd:string
created_by: George Gkoutos

[Term]
id: NBO:0000073
name: chewing
namespace: behavior_ontology
def: "The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]" []
synonym: "chew" EXACT []
synonym: "gnaw" EXACT []
synonym: "mastication" EXACT []
is_a: NBO:0000747 ! jaw movement
property_value: x_1.1:date "2011-04-14T01:20:02Z" xsd:string
created_by: George Gkoutos

[Term]
id: NBO:0000313
name: behavior process
namespace: behavior_ontology
alt_id: NBO:0000000
def: "\"The action, reaction, or performance of an organism in response to external or internal stimuli.\" [GO:GO\\:0007610]" []
synonym: "behavior" EXACT []
synonym: "behaviour" EXACT []
xref: GO:0007610
is_a: GO:0007610 ! behavior
property_value: x_1.1:date "2011-04-05T09:53:10Z" xsd:string
created_by: George Gkoutos

[Term]
id: NBO:0000338
name: kinesthetic behavior
namespace: behavior_ontology
def: "\"Movement behavior of the body or its parts.\"" []
is_a: NBO:0000313 ! behavior process
property_value: x_1.1:date "2011-04-05T02:08:47Z" xsd:string
created_by: George Gkoutos

[Term]
id: NBO:0000747
name: jaw movement
namespace: behavior_ontology
is_a: NBO:0000007 ! mouth movement
property_value: x_1.1:date "2012-03-17T09:51:17Z" xsd:string
created_by: gkoutos

[Term]
id: NBO:0001786
name: regulation of behavior
def: "\"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.\" [GO:0050795]" []
xref: GO:0050795
is_a: NBO:0000313 ! behavior process
relationship: regulates NBO:0000313 ! behavior process
created_by: George Gkoutos

[Term]
id: NCBITaxon:1
name: root
namespace: ncbi_taxonomy
synonym: "all" RELATED synonym []
xref: GC_ID:1
xref: PMID:30365038
xref: PMID:32761142

[Term]
id: NCBITaxon:10066
name: Muridae
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:15371245
is_a: NCBITaxon:337687 ! Muroidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:10088
name: Mus <genus>
namespace: ncbi_taxonomy
synonym: "mice" EXACT OMO:0003003 []
synonym: "mouse" EXACT OMO:0003003 []
synonym: "Mus" EXACT scientific_name []
xref: GC_ID:1
is_a: NCBITaxon:39107 ! Murinae
disjoint_from: NCBITaxon:10114 ! Rattus
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:10090
name: Mus musculus
namespace: ncbi_taxonomy
alt_id: NCBITaxon:85055
synonym: "house mouse" EXACT genbank_common_name []
synonym: "mouse" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:862507 ! Mus <subgenus>
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:10114
name: Rattus
namespace: ncbi_taxonomy
synonym: "rat" EXACT OMO:0003003 []
synonym: "rats" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:39107 ! Murinae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:105389
name: Sedentaria
namespace: ncbi_taxonomy
synonym: "Palpata" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:6341 ! Polychaeta
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:105391
name: Canalipalpata
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:105389 ! Sedentaria
property_value: has_rank NCBITaxon:infraclass

[Term]
id: NCBITaxon:110814
name: Xenoturbellida
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1312402 ! Xenacoelomorpha
disjoint_from: NCBITaxon:147099 ! Acoelomorpha
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:110815
name: Xenoturbella
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1547233 ! Xenoturbellidae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:117565
name: Myxini
namespace: ncbi_taxonomy
synonym: "Agnatha" RELATED in_part []
synonym: "fish" EXACT OMO:0003003 []
synonym: "fishes" EXACT OMO:0003003 []
synonym: "Hyperotreti" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:1476529 ! Cyclostomata
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:117570
name: Teleostomi
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7776 ! Gnathostomata <vertebrates>
disjoint_from: NCBITaxon:7777 ! Chondrichthyes
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:117571
name: Euteleostomi
namespace: ncbi_taxonomy
alt_id: NCBITaxon:40673
synonym: "bony vertebrates" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:117570 ! Teleostomi
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:119089
name: Chromadorea
namespace: ncbi_taxonomy
alt_id: NCBITaxon:27837
synonym: "Adenophorea" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:6231 ! Nematoda
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:1206794
name: Ecdysozoa
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33317 ! Protostomia
disjoint_from: NCBITaxon:2697495 ! Spiralia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1206795
name: Lophotrochozoa
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2697495 ! Spiralia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:123365
name: Neoteleostei
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1489388 ! Euteleosteomorpha
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:123366
name: Eurypterygia
namespace: ncbi_taxonomy
synonym: "Eurypterygii" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:123365 ! Neoteleostei
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:123367
name: Ctenosquamata
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:123366 ! Eurypterygia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:123368
name: Acanthomorphata
namespace: ncbi_taxonomy
synonym: "Acanthomorpha" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:123367 ! Ctenosquamata
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:123369
name: Euacanthomorphacea
namespace: ncbi_taxonomy
synonym: "Euacanthomorpha" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:123368 ! Acanthomorphata
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:124129
name: Acipenserinae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7900 ! Acipenseridae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:124130
name: Acipenserini
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:124129 ! Acipenserinae
property_value: has_rank NCBITaxon:tribe

[Term]
id: NCBITaxon:131209
name: Zygnemophyceae
namespace: ncbi_taxonomy
synonym: "Conjugatophyceae" RELATED synonym []
synonym: "Gamophyceae" RELATED synonym []
synonym: "Gamophyta" RELATED synonym []
synonym: "gamophytes" EXACT OMO:0003003 []
synonym: "Zygnematophyceae" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:131221 ! Streptophytina
disjoint_from: NCBITaxon:3193 ! Embryophyta
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:131221
name: Streptophytina
namespace: ncbi_taxonomy
synonym: "Charophyta/Embryophyta group" RELATED synonym []
synonym: "charophyte/embryophyte group" EXACT equivalent_name []
xref: GC_ID:1
is_a: NCBITaxon:35493 ! Streptophyta
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:1312402
name: Xenacoelomorpha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33213 ! Bilateria
disjoint_from: NCBITaxon:33317 ! Protostomia
disjoint_from: NCBITaxon:33511 ! Deuterostomia
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:131567
name: cellular organisms
namespace: ncbi_taxonomy
synonym: "biota" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:1 ! root

[Term]
id: NCBITaxon:1329799
name: Archelosauria
namespace: ncbi_taxonomy
synonym: "Archosauria-Testudines" RELATED synonym []
synonym: "Testudines + Archosauria group" RELATED synonym []
xref: GC_ID:1
xref: PMID:22839753
xref: PMID:25450099
is_a: NCBITaxon:32561 ! Sauria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1338369
name: Dipnotetrapodomorpha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8287 ! Sarcopterygii
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:142796
name: Eumycetozoa
namespace: ncbi_taxonomy
synonym: "Eumycetozoa Zopf, 1884" RELATED synonym []
synonym: "Mycetozoa" RELATED synonym []
synonym: "mycetozoans" RELATED synonym []
xref: GC_ID:1
xref: PMID:11062127
xref: PMID:9342353
is_a: NCBITaxon:2605435 ! Evosea
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:1437010
name: Boreoeutheria
namespace: ncbi_taxonomy
synonym: "Boreotheria" RELATED synonym []
xref: GC_ID:1
xref: PMID:11743200
xref: PMID:11791233
is_a: NCBITaxon:9347 ! Eutheria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1437180
name: Acrogymnospermae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:58024 ! Spermatophyta
disjoint_from: NCBITaxon:3398 ! Magnoliopsida
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1445966
name: Gnetidae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:3372 ! Gnetopsida
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:147099
name: Acoelomorpha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1312402 ! Xenacoelomorpha
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:147537
name: Saccharomycotina
namespace: ncbi_taxonomy
synonym: "true yeasts" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:716545 ! saccharomyceta
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:147554
name: Schizosaccharomycetes
namespace: ncbi_taxonomy
synonym: "Archiascomycota" RELATED in_part []
xref: GC_ID:1
is_a: NCBITaxon:451866 ! Taphrinomycotina
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:1476529
name: Cyclostomata
namespace: ncbi_taxonomy
synonym: "Agnatha" RELATED synonym []
synonym: "jawless vertebrates" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:7742 ! Vertebrata <vertebrates>
disjoint_from: NCBITaxon:7776 ! Gnathostomata <vertebrates>
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1489341
name: Osteoglossocephalai
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:32443 ! Teleostei
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1489388
name: Euteleosteomorpha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:186625 ! Clupeocephala
disjoint_from: NCBITaxon:186634 ! Otomorpha
property_value: has_rank NCBITaxon:cohort

[Term]
id: NCBITaxon:1489872
name: Percomorphaceae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:123369 ! Euacanthomorphacea
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1489922
name: Eupercaria
namespace: ncbi_taxonomy
synonym: "Percomorpharia" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:1489872 ! Percomorphaceae
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:1547233
name: Xenoturbellidae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:110814 ! Xenoturbellida
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:186622
name: Acipenseroidei
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7899 ! Acipenseriformes
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:186623
name: Actinopteri
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7898 ! Actinopterygii
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:186625
name: Clupeocephala
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1489341 ! Osteoglossocephalai

[Term]
id: NCBITaxon:186626
name: Otophysi
namespace: ncbi_taxonomy
synonym: "Otophysa" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:32519 ! Ostariophysi
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:186627
name: Cypriniphysae
namespace: ncbi_taxonomy
synonym: "Cypriniphysi" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:186626 ! Otophysi
property_value: has_rank NCBITaxon:superorder

[Term]
id: NCBITaxon:186634
name: Otomorpha
namespace: ncbi_taxonomy
synonym: "Ostarioclupeomorpha" RELATED synonym []
synonym: "Otocephala" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:186625 ! Clupeocephala
property_value: has_rank NCBITaxon:cohort

[Term]
id: NCBITaxon:1963758
name: Myomorpha
namespace: ncbi_taxonomy
synonym: "mice and others" EXACT genbank_common_name []
synonym: "Sciurognathi" RELATED in_part []
xref: GC_ID:1
is_a: NCBITaxon:9989 ! Rodentia
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:197562
name: Pancrustacea
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:10874751
xref: PMID:11557979
is_a: NCBITaxon:197563 ! Mandibulata
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:197563
name: Mandibulata
namespace: ncbi_taxonomy
synonym: "mandibulates" EXACT OMO:0003003 []
xref: GC_ID:1
xref: PMID:11557979
xref: PMID:9727836
is_a: NCBITaxon:6656 ! Arthropoda
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:2
name: Bacteria
namespace: ncbi_taxonomy
synonym: "bacteria" RELATED blast_name []
synonym: "eubacteria" EXACT genbank_common_name []
synonym: "Monera" RELATED in_part []
synonym: "Procaryotae" RELATED in_part []
synonym: "Prokaryota" RELATED in_part []
synonym: "Prokaryotae" RELATED in_part []
synonym: "prokaryote" RELATED in_part []
synonym: "prokaryotes" RELATED in_part []
xref: GC_ID:11
xref: PMID:10425795
xref: PMID:10425796
xref: PMID:10425797
xref: PMID:10490293
xref: PMID:10843050
xref: PMID:10939651
xref: PMID:10939673
xref: PMID:10939677
xref: PMID:11211268
xref: PMID:11321083
xref: PMID:11321113
xref: PMID:11411719
xref: PMID:11540071
xref: PMID:11542017
xref: PMID:11542087
xref: PMID:11760965
xref: PMID:12054223
xref: PMID:2112744
xref: PMID:270744
xref: PMID:32628106
xref: PMID:36748408
xref: PMID:7520741
xref: PMID:8123559
xref: PMID:8186100
xref: PMID:8590690
xref: PMID:9103655
xref: PMID:9336922
is_a: NCBITaxon:131567 ! cellular organisms
disjoint_from: NCBITaxon:2157 ! Archaea
disjoint_from: NCBITaxon:2759 ! Eukaryota
property_value: has_rank NCBITaxon:superkingdom

[Term]
id: NCBITaxon:2058185
name: Dictyosteliaceae
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:29367151
is_a: NCBITaxon:2058949 ! Dictyosteliales
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:2058949
name: Dictyosteliales
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:29367151
is_a: NCBITaxon:33083 ! Dictyostelia
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:207598
name: Homininae
namespace: ncbi_taxonomy
synonym: "Homo/Pan/Gorilla group" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:9604 ! Hominidae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:2157
name: Archaea
namespace: ncbi_taxonomy
synonym: "archaea" RELATED blast_name []
synonym: "Archaebacteria" RELATED synonym []
synonym: "Mendosicutes" RELATED synonym []
synonym: "Metabacteria" RELATED synonym []
synonym: "Monera" RELATED in_part []
synonym: "Procaryotae" RELATED in_part []
synonym: "Prokaryota" RELATED in_part []
synonym: "Prokaryotae" RELATED in_part []
synonym: "prokaryote" RELATED in_part []
synonym: "prokaryotes" RELATED in_part []
xref: GC_ID:11
xref: PMID:10425795
xref: PMID:10425796
xref: PMID:10425797
xref: PMID:10490293
xref: PMID:10843050
xref: PMID:10939651
xref: PMID:10939673
xref: PMID:10939677
xref: PMID:11211268
xref: PMID:11321083
xref: PMID:11321113
xref: PMID:11411719
xref: PMID:11540071
xref: PMID:11541975
xref: PMID:11542064
xref: PMID:11542149
xref: PMID:11760965
xref: PMID:12054223
xref: PMID:2112744
xref: PMID:25527841
xref: PMID:270744
xref: PMID:32628106
xref: PMID:36748408
xref: PMID:8123559
xref: PMID:8590690
xref: PMID:9103655
xref: PMID:9336922
is_a: NCBITaxon:131567 ! cellular organisms
disjoint_from: NCBITaxon:2759 ! Eukaryota
property_value: has_rank NCBITaxon:superkingdom

[Term]
id: NCBITaxon:2301116
name: Rhabditina
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:6236 ! Rhabditida
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:2301119
name: Rhabditomorpha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2301116 ! Rhabditina
property_value: has_rank NCBITaxon:infraorder

[Term]
id: NCBITaxon:2605435
name: Evosea
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:2611352
name: Discoba
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2759 ! Eukaryota
disjoint_from: NCBITaxon:2698737 ! Sar
disjoint_from: NCBITaxon:33090 ! Viridiplantae
disjoint_from: NCBITaxon:33154 ! Opisthokonta
disjoint_from: NCBITaxon:38254 ! Glaucocystophyceae
disjoint_from: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:262014
name: Xenopus <subgenus>
namespace: ncbi_taxonomy
synonym: "Xenopus" EXACT scientific_name []
xref: GC_ID:1
is_a: NCBITaxon:8353 ! Xenopus <genus>
property_value: has_rank NCBITaxon:subgenus

[Term]
id: NCBITaxon:2684882
name: Zygnematophycidae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:131209 ! Zygnemophyceae
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:2697495
name: Spiralia
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33317 ! Protostomia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:2698737
name: Sar
namespace: ncbi_taxonomy
synonym: "SAR supergroup" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:2759 ! Eukaryota
disjoint_from: NCBITaxon:33090 ! Viridiplantae
disjoint_from: NCBITaxon:33154 ! Opisthokonta
disjoint_from: NCBITaxon:38254 ! Glaucocystophyceae
disjoint_from: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:2743709
name: Danionidae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:30727 ! Cyprinoidei
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:2743711
name: Danioninae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2743709 ! Danionidae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:2759
name: Eukaryota
namespace: ncbi_taxonomy
synonym: "Eucarya" RELATED synonym []
synonym: "Eucaryotae" RELATED synonym []
synonym: "eucaryotes" EXACT genbank_common_name []
synonym: "euk-" RELATED PRO-short-label [PRO:DAN]
synonym: "Eukarya" RELATED synonym []
synonym: "Eukaryotae" RELATED synonym []
synonym: "eukaryotes" EXACT OMO:0003003 []
synonym: "eukaryotes" RELATED blast_name []
xref: GC_ID:1
xref: PMID:23020233
xref: PMID:30257078
is_a: NCBITaxon:131567 ! cellular organisms
is_a: OBI:0100026 ! organism
property_value: has_rank NCBITaxon:superkingdom

[Term]
id: NCBITaxon:30319
name: Pipoidea
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8342 ! Anura
property_value: has_rank NCBITaxon:superfamily

[Term]
id: NCBITaxon:30727
name: Cyprinoidei
namespace: ncbi_taxonomy
synonym: "Cyprinoidea" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:7952 ! Cypriniformes
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:31022
name: Tetraodontiformes
namespace: ncbi_taxonomy
synonym: "pufferfishes and others" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:1489922 ! Eupercaria
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:31028
name: Tetraodontoidei
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:31022 ! Tetraodontiformes
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:31031
name: Tetraodontidae
namespace: ncbi_taxonomy
synonym: "puffer fishes" EXACT OMO:0003003 []
synonym: "puffers" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:32517 ! Tetradontoidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:31032
name: Takifugu
namespace: ncbi_taxonomy
synonym: "Fugu" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:31031 ! Tetraodontidae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:31033
name: Takifugu rubripes
namespace: ncbi_taxonomy
synonym: "Fugu rubripes" RELATED synonym []
synonym: "Sphaeroides rubripes" RELATED synonym []
synonym: "Tetraodon rubripes" RELATED synonym []
synonym: "tiger puffer" EXACT OMO:0003003 []
synonym: "torafugu" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:31032 ! Takifugu
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:314146
name: Euarchontoglires
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:11214319
xref: PMID:12082125
xref: PMID:12878460
xref: PMID:15522813
is_a: NCBITaxon:1437010 ! Boreoeutheria
property_value: has_rank NCBITaxon:superorder

[Term]
id: NCBITaxon:314147
name: Glires
namespace: ncbi_taxonomy
synonym: "Rodents and rabbits" EXACT genbank_common_name []
xref: GC_ID:1
xref: PMID:11214319
xref: PMID:12082125
xref: PMID:15522813
is_a: NCBITaxon:314146 ! Euarchontoglires
disjoint_from: NCBITaxon:9443 ! Primates
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:314293
name: Simiiformes
namespace: ncbi_taxonomy
synonym: "Anthropoidea" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:376913 ! Haplorrhini
property_value: has_rank NCBITaxon:infraorder

[Term]
id: NCBITaxon:314295
name: Hominoidea
namespace: ncbi_taxonomy
synonym: "ape" EXACT OMO:0003003 []
synonym: "apes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:9526 ! Catarrhini
property_value: has_rank NCBITaxon:superfamily

[Term]
id: NCBITaxon:3176
name: Zygnematales
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2684882 ! Zygnematophycidae
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:3193
name: Embryophyta
namespace: ncbi_taxonomy
synonym: "higher plants" EXACT OMO:0003003 []
synonym: "land plants" EXACT OMO:0003003 []
synonym: "land plants" RELATED blast_name []
synonym: "plants" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:131221 ! Streptophytina
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:32341
name: Sophophora
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7215 ! Drosophila <flies,genus>
property_value: has_rank NCBITaxon:subgenus

[Term]
id: NCBITaxon:32346
name: melanogaster group
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:32341 ! Sophophora
property_value: has_rank NCBITaxon:species_group

[Term]
id: NCBITaxon:32351
name: melanogaster subgroup
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:32346 ! melanogaster group
property_value: has_rank NCBITaxon:species_subgroup

[Term]
id: NCBITaxon:32440
name: Chondrostei
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:186623 ! Actinopteri
disjoint_from: NCBITaxon:41665 ! Neopterygii
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:32443
name: Teleostei
namespace: ncbi_taxonomy
synonym: "teleost fishes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:41665 ! Neopterygii
property_value: has_rank NCBITaxon:infraclass

[Term]
id: NCBITaxon:32517
name: Tetradontoidea
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:31028 ! Tetraodontoidei
property_value: has_rank NCBITaxon:superfamily

[Term]
id: NCBITaxon:32519
name: Ostariophysi
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:186634 ! Otomorpha
property_value: has_rank NCBITaxon:subcohort

[Term]
id: NCBITaxon:32523
name: Tetrapoda
namespace: ncbi_taxonomy
synonym: "tetrapods" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha
disjoint_from: NCBITaxon:7878 ! Dipnomorpha
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:32524
name: Amniota
namespace: ncbi_taxonomy
synonym: "amniotes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:32523 ! Tetrapoda
disjoint_from: NCBITaxon:8292 ! Amphibia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:32525
name: Theria <mammals>
namespace: ncbi_taxonomy
synonym: "Theria" EXACT scientific_name []
xref: GC_ID:1
is_a: NCBITaxon:40674 ! Mammalia
disjoint_from: NCBITaxon:9254 ! Prototheria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:32561
name: Sauria
namespace: ncbi_taxonomy
synonym: "Diapsida" RELATED synonym []
synonym: "diapsids" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:8457 ! Sauropsida
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33083
name: Dictyostelia
namespace: ncbi_taxonomy
synonym: "cellular slime molds" RELATED blast_name []
synonym: "dictyostelid cellular slime molds" EXACT genbank_common_name []
synonym: "Dictyostelida" RELATED synonym []
synonym: "Dictyostelids" RELATED synonym []
synonym: "Dictyosteliida" RELATED synonym []
xref: GC_ID:1
xref: PMID:11062127
xref: PMID:29367151
xref: PMID:9342353
is_a: NCBITaxon:142796 ! Eumycetozoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33090
name: Viridiplantae
namespace: ncbi_taxonomy
synonym: "Chlorobionta" RELATED synonym []
synonym: "Chlorophyta/Embryophyta group" EXACT equivalent_name []
synonym: "chlorophyte/embryophyte group" EXACT equivalent_name []
synonym: "Chloroplastida" RELATED synonym []
synonym: "green plants" EXACT OMO:0003003 []
synonym: "green plants" RELATED blast_name []
xref: GC_ID:1
xref: PMID:16248873
xref: PMID:30257078
is_a: NCBITaxon:2759 ! Eukaryota
disjoint_from: NCBITaxon:33154 ! Opisthokonta
disjoint_from: NCBITaxon:38254 ! Glaucocystophyceae
disjoint_from: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:kingdom

[Term]
id: NCBITaxon:3312
name: Coniferophyta
namespace: ncbi_taxonomy
synonym: "conifers" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:1437180 ! Acrogymnospermae
disjoint_from: NCBITaxon:3372 ! Gnetopsida
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33154
name: Opisthokonta
namespace: ncbi_taxonomy
synonym: "Fungi/Metazoa group" RELATED synonym []
synonym: "opisthokonts" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:2759 ! Eukaryota
disjoint_from: NCBITaxon:38254 ! Glaucocystophyceae
disjoint_from: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33208
name: Metazoa
namespace: ncbi_taxonomy
synonym: "Animalia" RELATED synonym []
synonym: "animals" RELATED blast_name []
synonym: "metazoans" EXACT genbank_common_name []
synonym: "multicellular animals" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:33154 ! Opisthokonta
disjoint_from: NCBITaxon:4751 ! Fungi
property_value: has_rank NCBITaxon:kingdom

[Term]
id: NCBITaxon:33213
name: Bilateria
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:6072 ! Eumetazoa
disjoint_from: NCBITaxon:6073 ! Cnidaria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33317
name: Protostomia
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33213 ! Bilateria
disjoint_from: NCBITaxon:33511 ! Deuterostomia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33340
name: Neoptera
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7496 ! Pterygota <insects>
property_value: has_rank NCBITaxon:infraclass

[Term]
id: NCBITaxon:33392
name: Endopterygota
namespace: ncbi_taxonomy
synonym: "Holometabola" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:33340 ! Neoptera
property_value: has_rank NCBITaxon:cohort

[Term]
id: NCBITaxon:33511
name: Deuterostomia
namespace: ncbi_taxonomy
synonym: "deuterostomes" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:33213 ! Bilateria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33630
name: Alveolata
namespace: ncbi_taxonomy
synonym: "alveolates" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:2698737 ! Sar
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:33682
name: Euglenozoa
namespace: ncbi_taxonomy
synonym: "Euglenozoans" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:2611352 ! Discoba
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:3372
name: Gnetopsida
namespace: ncbi_taxonomy
synonym: "Chlamydospermopsida" RELATED synonym []
synonym: "Gneticae" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:1437180 ! Acrogymnospermae
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:337687
name: Muroidea
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:15019624
xref: PMID:15371245
is_a: NCBITaxon:1963758 ! Myomorpha
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:3378
name: Gnetales
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1445966 ! Gnetidae
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:3398
name: Magnoliopsida
namespace: ncbi_taxonomy
synonym: "Angiospermae" RELATED synonym []
synonym: "angiosperms" EXACT OMO:0003003 []
synonym: "flowering plants" EXACT genbank_common_name []
synonym: "flowering plants" RELATED blast_name []
synonym: "Magnoliophyta" RELATED synonym []
xref: GC_ID:1
xref: PMID:25249442
is_a: NCBITaxon:58024 ! Spermatophyta
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:34346
name: Schizosaccharomycetales
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:147554 ! Schizosaccharomycetes
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:35493
name: Streptophyta
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33090 ! Viridiplantae
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:376913
name: Haplorrhini
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:9443 ! Primates
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:38254
name: Glaucocystophyceae
namespace: ncbi_taxonomy
synonym: "algae" RELATED in_part []
synonym: "glaucocystophytes" EXACT OMO:0003003 []
synonym: "Glaucophyceae" RELATED synonym []
synonym: "Glaucophyta" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:2759 ! Eukaryota
disjoint_from: NCBITaxon:554915 ! Amoebozoa
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:39107
name: Murinae
namespace: ncbi_taxonomy
alt_id: NCBITaxon:109679
xref: GC_ID:1
is_a: NCBITaxon:10066 ! Muridae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:40674
name: Mammalia
namespace: ncbi_taxonomy
synonym: "mammals" EXACT genbank_common_name []
synonym: "mammals" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:32524 ! Amniota
disjoint_from: NCBITaxon:8457 ! Sauropsida
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:41324
name: Siboglinidae
namespace: ncbi_taxonomy
alt_id: NCBITaxon:167797
alt_id: NCBITaxon:27906
alt_id: NCBITaxon:29174
alt_id: NCBITaxon:41329
alt_id: NCBITaxon:54122
alt_id: NCBITaxon:55674
alt_id: NCBITaxon:55678
alt_id: NCBITaxon:6422
synonym: "Frenulata" RELATED synonym []
synonym: "Lamellibrachiidae" RELATED synonym []
synonym: "Obturata" RELATED synonym []
synonym: "Oligobrachiidae" RELATED synonym []
synonym: "Perviata" RELATED synonym []
synonym: "Pogonophora" RELATED synonym []
synonym: "pogonophores" EXACT OMO:0003003 []
synonym: "Polybrachiidae" RELATED synonym []
synonym: "Sclerolinidae" RELATED synonym []
synonym: "tube worms" RELATED blast_name []
synonym: "Vestimentifera" RELATED synonym []
synonym: "vestimentiferans" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:6362 ! Sabellida
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:41665
name: Neopterygii
namespace: ncbi_taxonomy
synonym: "Neopterygi" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:186623 ! Actinopteri
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:41666
name: Batrachia
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8292 ! Amphibia
property_value: has_rank NCBITaxon:superorder

[Term]
id: NCBITaxon:436486
name: Dinosauria
namespace: ncbi_taxonomy
synonym: "dinosaur" EXACT OMO:0003003 []
synonym: "dinosaurs" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:8492 ! Archosauria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:436489
name: Saurischia
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:436486 ! Dinosauria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:436491
name: Theropoda
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:436489 ! Saurischia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:436492
name: Coelurosauria
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:436491 ! Theropoda
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:43733
name: Muscomorpha
namespace: ncbi_taxonomy
alt_id: NCBITaxon:43732
synonym: "Asilomorpha" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:7203 ! Brachycera
property_value: has_rank NCBITaxon:infraorder

[Term]
id: NCBITaxon:43738
name: Schizophora
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:480117 ! Cyclorrhapha

[Term]
id: NCBITaxon:43741
name: Acalyptratae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:43738 ! Schizophora

[Term]
id: NCBITaxon:43746
name: Ephydroidea
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:43741 ! Acalyptratae
property_value: has_rank NCBITaxon:superfamily

[Term]
id: NCBITaxon:43845
name: Drosophilinae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7214 ! Drosophilidae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:451864
name: Dikarya
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:15689432
xref: PMID:16151185
xref: PMID:17010206
xref: PMID:17051209
xref: PMID:17572334
is_a: NCBITaxon:4751 ! Fungi
property_value: has_rank NCBITaxon:subkingdom

[Term]
id: NCBITaxon:451866
name: Taphrinomycotina
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:4890 ! Ascomycota
disjoint_from: NCBITaxon:716545 ! saccharomyceta
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:46877
name: Drosophilini
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:43845 ! Drosophilinae
property_value: has_rank NCBITaxon:tribe

[Term]
id: NCBITaxon:4751
name: Fungi
namespace: ncbi_taxonomy
synonym: "fungi" RELATED blast_name []
synonym: "Mycota" RELATED synonym []
xref: GC_ID:1
xref: PMID:11062127
xref: PMID:12684019
is_a: NCBITaxon:33154 ! Opisthokonta
property_value: has_rank NCBITaxon:kingdom

[Term]
id: NCBITaxon:480117
name: Cyclorrhapha
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:480118 ! Eremoneura
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:480118
name: Eremoneura
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:43733 ! Muscomorpha
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:4890
name: Ascomycota
namespace: ncbi_taxonomy
synonym: "ascomycete fungi" RELATED blast_name []
synonym: "ascomycetes" EXACT genbank_common_name []
synonym: "sac fungi" EXACT OMO:0003003 []
xref: GC_ID:1
xref: PMID:17572334
is_a: NCBITaxon:451864 ! Dikarya
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:4891
name: Saccharomycetes
namespace: ncbi_taxonomy
synonym: "Hemiascomycetes" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:147537 ! Saccharomycotina
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:4892
name: Saccharomycetales
namespace: ncbi_taxonomy
synonym: "budding yeasts" RELATED blast_name []
synonym: "Endomycetales" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:4891 ! Saccharomycetes
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:4893
name: Saccharomycetaceae
namespace: ncbi_taxonomy
alt_id: NCBITaxon:221665
alt_id: NCBITaxon:44280
xref: GC_ID:1
is_a: NCBITaxon:4892 ! Saccharomycetales
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:4894
name: Schizosaccharomycetaceae
namespace: ncbi_taxonomy
synonym: "fission yeasts" EXACT genbank_common_name []
synonym: "Schizosaccharomycetoideae" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:34346 ! Schizosaccharomycetales
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:4895
name: Schizosaccharomyces
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:4894 ! Schizosaccharomycetaceae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:4896
name: Schizosaccharomyces pombe
namespace: ncbi_taxonomy
alt_id: NCBITaxon:45042
synonym: "fission yeast" EXACT genbank_common_name []
synonym: "Schizosaccharomyces malidevorans" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:4895 ! Schizosaccharomyces
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:4930
name: Saccharomyces
namespace: ncbi_taxonomy
alt_id: NCBITaxon:36915
synonym: "Pachytichospora" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:4893 ! Saccharomycetaceae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:4932
name: Saccharomyces cerevisiae
namespace: ncbi_taxonomy
alt_id: NCBITaxon:41870
synonym: "baker's yeast" EXACT OMO:0003003 []
synonym: "brewer's yeast" EXACT genbank_common_name []
synonym: "Candida robusta" RELATED synonym []
synonym: "Mycoderma cerevisiae" RELATED synonym []
synonym: "Saccharomyces capensis" RELATED synonym []
synonym: "Saccharomyces cerevisiae 'var. diastaticus'" EXACT equivalent_name []
synonym: "Saccharomyces diastaticus" RELATED synonym []
synonym: "Saccharomyces italicus" RELATED synonym []
synonym: "Saccharomyces oviformis" RELATED synonym []
synonym: "Saccharomyces uvarum var. melibiosus" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:4930 ! Saccharomyces
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:50557
name: Insecta
namespace: ncbi_taxonomy
synonym: "insects" RELATED blast_name []
synonym: "true insects" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:6960 ! Hexapoda
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:554915
name: Amoebozoa
namespace: ncbi_taxonomy
xref: GC_ID:1
xref: PMID:23020233
xref: PMID:30257078
is_a: NCBITaxon:2759 ! Eukaryota
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:55879
name: Rhabditoidea
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:2301119 ! Rhabditomorpha
property_value: has_rank NCBITaxon:superfamily

[Term]
id: NCBITaxon:55885
name: Peloderinae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:6243 ! Rhabditidae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:5782
name: Dictyostelium
namespace: ncbi_taxonomy
synonym: "Hyalostilbum" RELATED synonym []
xref: GC_ID:1
xref: PMID:29367151
is_a: NCBITaxon:2058185 ! Dictyosteliaceae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:58023
name: Tracheophyta
namespace: ncbi_taxonomy
synonym: "vascular plants" EXACT OMO:0003003 []
synonym: "vascular plants" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:3193 ! Embryophyta
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:58024
name: Spermatophyta
namespace: ncbi_taxonomy
synonym: "seed plants" EXACT OMO:0003003 []
synonym: "seed plants" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:78536 ! Euphyllophyta
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:6040
name: Porifera
namespace: ncbi_taxonomy
synonym: "Parazoa" RELATED synonym []
synonym: "sponges" EXACT genbank_common_name []
synonym: "sponges" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:33208 ! Metazoa
disjoint_from: NCBITaxon:6072 ! Eumetazoa
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6072
name: Eumetazoa
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:33208 ! Metazoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:6073
name: Cnidaria
namespace: ncbi_taxonomy
synonym: "cnidarians" EXACT genbank_common_name []
synonym: "cnidarians" RELATED blast_name []
synonym: "Coelenterata" RELATED in_part []
synonym: "coelenterates" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:6072 ! Eumetazoa
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6157
name: Platyhelminthes
namespace: ncbi_taxonomy
synonym: "flatworm" EXACT OMO:0003003 []
synonym: "flatworms" EXACT genbank_common_name []
synonym: "flatworms" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:1206795 ! Lophotrochozoa
disjoint_from: NCBITaxon:6340 ! Annelida
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6231
name: Nematoda
namespace: ncbi_taxonomy
synonym: "Nemata" RELATED synonym []
synonym: "nematode" EXACT OMO:0003003 []
synonym: "nematodes" EXACT OMO:0003003 []
synonym: "nematodes" RELATED blast_name []
synonym: "roundworm" EXACT OMO:0003003 []
synonym: "roundworms" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:1206794 ! Ecdysozoa
disjoint_from: NCBITaxon:88770 ! Panarthropoda
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6236
name: Rhabditida
namespace: ncbi_taxonomy
alt_id: NCBITaxon:33251
alt_id: NCBITaxon:6308
synonym: "Strongylida" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:119089 ! Chromadorea
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:6237
name: Caenorhabditis
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:55885 ! Peloderinae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:6239
name: Caenorhabditis elegans
namespace: ncbi_taxonomy
synonym: "Rhabditis elegans" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:6237 ! Caenorhabditis
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:6243
name: Rhabditidae
namespace: ncbi_taxonomy
alt_id: NCBITaxon:54603
xref: GC_ID:1
is_a: NCBITaxon:55879 ! Rhabditoidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:6340
name: Annelida
namespace: ncbi_taxonomy
synonym: "annelid worms" EXACT genbank_common_name []
synonym: "segmented worms" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:1206795 ! Lophotrochozoa
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6341
name: Polychaeta
namespace: ncbi_taxonomy
synonym: "polychaetes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:6340 ! Annelida
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:6362
name: Sabellida
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:105391 ! Canalipalpata
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:6656
name: Arthropoda
namespace: ncbi_taxonomy
synonym: "arthropods" EXACT genbank_common_name []
synonym: "arthropods" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:88770 ! Panarthropoda
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:6960
name: Hexapoda
namespace: ncbi_taxonomy
synonym: "Atelocerata" RELATED in_part []
synonym: "hexapods" RELATED blast_name []
synonym: "insects" EXACT genbank_common_name []
synonym: "Tracheata" RELATED in_part []
synonym: "Uniramia" RELATED in_part []
xref: GC_ID:1
is_a: NCBITaxon:197562 ! Pancrustacea
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:7147
name: Diptera
namespace: ncbi_taxonomy
synonym: "flies" EXACT genbank_common_name []
synonym: "flies" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:33392 ! Endopterygota
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:716545
name: saccharomyceta
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:4890 ! Ascomycota
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:7203
name: Brachycera
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7147 ! Diptera
property_value: has_rank NCBITaxon:suborder

[Term]
id: NCBITaxon:7214
name: Drosophilidae
namespace: ncbi_taxonomy
synonym: "pomace flies" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:43746 ! Ephydroidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:7215
name: Drosophila <flies,genus>
namespace: ncbi_taxonomy
alt_id: NCBITaxon:7326
synonym: "Drosophila" EXACT scientific_name []
synonym: "fruit flies" EXACT genbank_common_name []
synonym: "fruit fly" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:46877 ! Drosophilini
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:7227
name: Drosophila melanogaster
namespace: ncbi_taxonomy
alt_id: NCBITaxon:2267365
synonym: "fruit fly" EXACT genbank_common_name []
synonym: "Sophophora melanogaster" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:32351 ! melanogaster subgroup
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:7496
name: Pterygota <insects>
namespace: ncbi_taxonomy
synonym: "Pterygota" EXACT scientific_name []
synonym: "winged insects" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:85512 ! Dicondylia
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:7711
name: Chordata
namespace: ncbi_taxonomy
synonym: "chordates" EXACT genbank_common_name []
synonym: "chordates" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:33511 ! Deuterostomia
property_value: has_rank NCBITaxon:phylum

[Term]
id: NCBITaxon:7712
name: Tunicata
namespace: ncbi_taxonomy
synonym: "tunicates" EXACT genbank_common_name []
synonym: "tunicates" RELATED blast_name []
synonym: "Urochordata" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:7711 ! Chordata
disjoint_from: NCBITaxon:89593 ! Craniata <chordates>
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:7742
name: Vertebrata <vertebrates>
namespace: ncbi_taxonomy
synonym: "Vertebrata" EXACT scientific_name []
synonym: "vertebrates" EXACT genbank_common_name []
synonym: "vertebrates" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:89593 ! Craniata <chordates>
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:7761
name: Myxiniformes
namespace: ncbi_taxonomy
synonym: "hagfishes" RELATED blast_name []
synonym: "Myxinoidea" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:117565 ! Myxini
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:7762
name: Myxinidae
namespace: ncbi_taxonomy
synonym: "hagfishes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:7761 ! Myxiniformes
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:7776
name: Gnathostomata <vertebrates>
namespace: ncbi_taxonomy
synonym: "Gnathostomata" EXACT scientific_name []
synonym: "jawed vertebrates" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:7742 ! Vertebrata <vertebrates>
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:7777
name: Chondrichthyes
namespace: ncbi_taxonomy
synonym: "cartilaginous fishes" EXACT genbank_common_name []
synonym: "cartilaginous fishes" RELATED blast_name []
synonym: "fish" EXACT OMO:0003003 []
synonym: "fishes" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:7776 ! Gnathostomata <vertebrates>
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:78536
name: Euphyllophyta
namespace: ncbi_taxonomy
synonym: "euphyllophytes" EXACT equivalent_name []
xref: GC_ID:1
is_a: NCBITaxon:58023 ! Tracheophyta
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:7863
name: Holocephali
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:7777 ! Chondrichthyes
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:7864
name: Chimaeriformes
namespace: ncbi_taxonomy
synonym: "chimaeras" EXACT genbank_common_name []
synonym: "chimaeras" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:7863 ! Holocephali
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:7878
name: Dipnomorpha
namespace: ncbi_taxonomy
synonym: "Choanichthyes" RELATED in_part []
synonym: "Dipneusti" RELATED synonym []
synonym: "dipnoans" EXACT OMO:0003003 []
synonym: "Dipnoi" RELATED synonym []
synonym: "fish" EXACT OMO:0003003 []
synonym: "fishes" EXACT OMO:0003003 []
synonym: "lungfishes" EXACT genbank_common_name []
synonym: "lungfishes" RELATED blast_name []
synonym: "Osteichthyes" RELATED in_part []
xref: GC_ID:1
is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha
property_value: has_rank NCBITaxon:subclass

[Term]
id: NCBITaxon:7898
name: Actinopterygii
namespace: ncbi_taxonomy
synonym: "Actinopterygi" RELATED synonym []
synonym: "bony fishes" RELATED blast_name []
synonym: "fish" EXACT OMO:0003003 []
synonym: "fishes" EXACT OMO:0003003 []
synonym: "Osteichthyes" RELATED in_part []
synonym: "ray-finned fishes" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:117571 ! Euteleostomi
disjoint_from: NCBITaxon:8287 ! Sarcopterygii
property_value: has_rank NCBITaxon:superclass

[Term]
id: NCBITaxon:7899
name: Acipenseriformes
namespace: ncbi_taxonomy
synonym: "sturgeons and paddlefish" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:32440 ! Chondrostei
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:7900
name: Acipenseridae
namespace: ncbi_taxonomy
synonym: "sturgeons" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:186622 ! Acipenseroidei
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:7901
name: Acipenser
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:124130 ! Acipenserini
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:7952
name: Cypriniformes
namespace: ncbi_taxonomy
synonym: "carps and others" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:186627 ! Cypriniphysae
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:7954
name: Danio
namespace: ncbi_taxonomy
alt_id: NCBITaxon:46777
alt_id: NCBITaxon:487617
synonym: "Brachydanio" RELATED synonym []
synonym: "Celestichthys" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:2743711 ! Danioninae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:7955
name: Danio rerio
namespace: ncbi_taxonomy
alt_id: NCBITaxon:27702
alt_id: NCBITaxon:37966
synonym: "Brachydanio rerio" RELATED synonym []
synonym: "Brachydanio rerio frankei" RELATED synonym []
synonym: "Cyprinus rerio" RELATED synonym []
synonym: "Danio frankei" RELATED synonym []
synonym: "Danio rerio frankei" RELATED synonym []
synonym: "leopard danio" EXACT OMO:0003003 []
synonym: "zebra danio" EXACT OMO:0003003 []
synonym: "zebra fish" EXACT OMO:0003003 []
synonym: "zebrafish" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:7954 ! Danio
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:8287
name: Sarcopterygii
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:117571 ! Euteleostomi
property_value: has_rank NCBITaxon:superclass

[Term]
id: NCBITaxon:8292
name: Amphibia
namespace: ncbi_taxonomy
synonym: "amphibians" EXACT genbank_common_name []
synonym: "amphibians" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:32523 ! Tetrapoda
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:8342
name: Anura
namespace: ncbi_taxonomy
synonym: "anurans" EXACT OMO:0003003 []
synonym: "frogs" EXACT OMO:0003003 []
synonym: "frogs & toads" RELATED blast_name []
synonym: "frogs and toads" EXACT genbank_common_name []
synonym: "Salientia" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:41666 ! Batrachia
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:8352
name: Pipidae
namespace: ncbi_taxonomy
synonym: "pipid frogs" EXACT OMO:0003003 []
synonym: "tongueless frogs" EXACT genbank_common_name []
xref: GC_ID:1
xref: PMID:2385174
is_a: NCBITaxon:30319 ! Pipoidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:8353
name: Xenopus <genus>
namespace: ncbi_taxonomy
synonym: "Xenopus" EXACT scientific_name []
xref: GC_ID:1
xref: PMID:2385174
is_a: NCBITaxon:8360 ! Xenopodinae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:8355
name: Xenopus laevis
namespace: ncbi_taxonomy
synonym: "African clawed frog" EXACT genbank_common_name []
synonym: "Bufo laevis" RELATED synonym []
synonym: "clawed frog" EXACT OMO:0003003 []
synonym: "common platanna" EXACT OMO:0003003 []
synonym: "platanna" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:262014 ! Xenopus <subgenus>
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:8360
name: Xenopodinae
namespace: ncbi_taxonomy
synonym: "Siluraninae" RELATED synonym []
xref: GC_ID:1
xref: PMID:2385174
is_a: NCBITaxon:8352 ! Pipidae
property_value: has_rank NCBITaxon:subfamily

[Term]
id: NCBITaxon:8457
name: Sauropsida
namespace: ncbi_taxonomy
synonym: "sauropsids" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:32524 ! Amniota
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:8492
name: Archosauria
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1329799 ! Archelosauria
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:85512
name: Dicondylia
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:50557 ! Insecta
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:862507
name: Mus <subgenus>
namespace: ncbi_taxonomy
synonym: "Mus" EXACT scientific_name []
xref: GC_ID:1
is_a: NCBITaxon:10088 ! Mus <genus>
property_value: has_rank NCBITaxon:subgenus

[Term]
id: NCBITaxon:8782
name: Aves
namespace: ncbi_taxonomy
synonym: "avian" RELATED synonym []
synonym: "birds" EXACT genbank_common_name []
synonym: "birds" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:436492 ! Coelurosauria
property_value: has_rank NCBITaxon:class

[Term]
id: NCBITaxon:8783
name: Palaeognathae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8782 ! Aves
disjoint_from: NCBITaxon:8825 ! Neognathae
property_value: has_rank NCBITaxon:superorder

[Term]
id: NCBITaxon:8798
name: Struthioniformes
namespace: ncbi_taxonomy
synonym: "ostriches" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:8783 ! Palaeognathae
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:8799
name: Struthionidae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8798 ! Struthioniformes
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:8800
name: Struthio
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8799 ! Struthionidae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:8801
name: Struthio camelus
namespace: ncbi_taxonomy
synonym: "African ostrich" EXACT genbank_common_name []
synonym: "ostrich" EXACT OMO:0003003 []
synonym: "Struthio camelus domesticus" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:8800 ! Struthio
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:8825
name: Neognathae
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:8782 ! Aves
property_value: has_rank NCBITaxon:infraclass

[Term]
id: NCBITaxon:88770
name: Panarthropoda
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:1206794 ! Ecdysozoa
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:8929
name: Columbiformes
namespace: ncbi_taxonomy
synonym: "pigeons and others" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:8825 ! Neognathae
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:8930
name: Columbidae
namespace: ncbi_taxonomy
synonym: "pigeons" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:8929 ! Columbiformes
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:89593
name: Craniata <chordates>
namespace: ncbi_taxonomy
synonym: "Craniata" EXACT scientific_name []
xref: GC_ID:1
is_a: NCBITaxon:7711 ! Chordata
property_value: has_rank NCBITaxon:subphylum

[Term]
id: NCBITaxon:9254
name: Prototheria
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:40674 ! Mammalia
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:9255
name: Monotremata
namespace: ncbi_taxonomy
synonym: "egg-laying mammals" EXACT genbank_common_name []
synonym: "monotremes" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:9254 ! Prototheria
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:9259
name: Tachyglossidae
namespace: ncbi_taxonomy
synonym: "echidnas" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:9255 ! Monotremata
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:9347
name: Eutheria
namespace: ncbi_taxonomy
synonym: "eutherian mammals" EXACT OMO:0003003 []
synonym: "placental mammals" EXACT OMO:0003003 []
synonym: "Placentalia" RELATED synonym []
synonym: "placentals" EXACT genbank_common_name []
synonym: "placentals" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:32525 ! Theria <mammals>
property_value: has_rank NCBITaxon:clade

[Term]
id: NCBITaxon:9443
name: Primates
namespace: ncbi_taxonomy
synonym: "Primata" RELATED synonym []
synonym: "primate" EXACT equivalent_name []
synonym: "primates" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:314146 ! Euarchontoglires
property_value: has_rank NCBITaxon:order

[Term]
id: NCBITaxon:9526
name: Catarrhini
namespace: ncbi_taxonomy
xref: GC_ID:1
is_a: NCBITaxon:314293 ! Simiiformes
property_value: has_rank NCBITaxon:parvorder

[Term]
id: NCBITaxon:9604
name: Hominidae
namespace: ncbi_taxonomy
synonym: "great apes" EXACT genbank_common_name []
synonym: "Pongidae" RELATED synonym []
xref: GC_ID:1
is_a: NCBITaxon:314295 ! Hominoidea
property_value: has_rank NCBITaxon:family

[Term]
id: NCBITaxon:9605
name: Homo
namespace: ncbi_taxonomy
synonym: "humans" EXACT OMO:0003003 []
xref: GC_ID:1
is_a: NCBITaxon:207598 ! Homininae
property_value: has_rank NCBITaxon:genus

[Term]
id: NCBITaxon:9606
name: Homo sapiens
namespace: ncbi_taxonomy
synonym: "human" EXACT genbank_common_name []
xref: GC_ID:1
is_a: NCBITaxon:9605 ! Homo
property_value: has_rank NCBITaxon:species

[Term]
id: NCBITaxon:9989
name: Rodentia
namespace: ncbi_taxonomy
synonym: "rodent" EXACT genbank_common_name []
synonym: "rodents" RELATED blast_name []
xref: GC_ID:1
is_a: NCBITaxon:314147 ! Glires
property_value: has_rank NCBITaxon:order

[Term]
id: OBI:0000011
name: planned process
def: "A process that realizes a plan which is the concretization of a plan specification." []
is_a: BFO:0000015 ! process
property_value: IAO:0000111 "planned process" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/obi.owl

[Term]
id: OBI:0100026
name: organism
namespace: obi
comment: Category=external.
is_a: BFO:0000030 ! object

[Term]
id: PATO:0000001
name: quality
namespace: quality
alt_id: PATO:0000072
def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG]
is_a: BFO:0000020 ! specifically dependent continuant

[Term]
id: PATO:0000025
name: composition
namespace: quality
alt_id: PATO:0002015
def: "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts." [PATOC:GVG]
comment: For example calcium composition (which may inhere in bone), haemoglobin composition (which may inhere in blood).
subset: attribute_slim
subset: scalar_slim
synonym: "composed of" EXACT []
synonym: "compositionality" EXACT []
synonym: "content" EXACT []
synonym: "structure, composition" EXACT []
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0000039
name: direction
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's orientation in space." []
def: "A physical quality inhering in a bearer by virtue of the bearer's orientation in space." [thesaurus.maths:thesaurus.maths]
comment: TODO: consider merging with angular placement.
subset: attribute_slim
is_a: PATO:0001018 ! physical quality

[Term]
id: PATO:0000040
name: distance
namespace: quality
def: "A quality that is the extent of space between two entities." [PATOC:GVG]
subset: attribute_slim
subset: relational_slim
subset: scalar_slim
is_a: PATO:0001018 ! physical quality

[Term]
id: PATO:0000051
name: morphology
namespace: quality
def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0001241 ! physical object quality
property_value: IAO:0000111 "morphology" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0000052
name: shape
namespace: quality
alt_id: PATO:0001647
def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG]
comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.
subset: attribute_slim
synonym: "relational shape quality" EXACT []
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000060
name: spatial pattern
namespace: quality
alt_id: PATO:0000132
alt_id: PATO:0001565
def: "A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts." [PATOC:GVG]
subset: attribute_slim
subset: hpo_slim
synonym: "distribution" EXACT []
synonym: "pattern" RELATED []
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000068
name: qualitative
namespace: quality
def: "A quality of an entity that is descriptive or observational, typically not represented numerically." [https://libguides.macalester.edu/c.php?g=527786&p=3608639, https://www.ncbi.nlm.nih.gov/books/NBK470395/]
comment: TODO: define this or obsolete it and move children somewhere else.
is_a: PATO:0000001 ! quality

[Term]
id: PATO:0000069
name: deviation (from_normal)
namespace: quality
def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0000068 ! qualitative

[Term]
id: PATO:0000070
name: amount
namespace: quality
alt_id: PATO:0000053
alt_id: PATO:0000071
alt_id: PATO:0001169
alt_id: PATO:0001226
def: "The number of entities of this type that are part of the whole organism." [PATOC:GVG]
comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10.
subset: attribute_slim
synonym: "count in organism" RELATED []
synonym: "number" RELATED []
synonym: "presence" RELATED []
synonym: "presence or absence in organism" EXACT []
synonym: "quantitative" EXACT []
is_a: PATO:0103000 ! quantitative
relationship: RO:0015012 PATO:0001555 ! has number of

[Term]
id: PATO:0000117
name: size
namespace: quality
def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet]
subset: attribute_slim
subset: scalar_slim
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000122
name: length
namespace: quality
def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG]
comment: Length often refers to the longer or longest dimension of an object, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
subset: attribute_slim
subset: mpath_slim
subset: scalar_slim
is_a: PATO:0001708 ! 1-D extent
property_value: IAO:0000111 "length" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl
property_value: seeAlso "https://github.com/pato-ontology/pato/issues/337" xsd:string

[Term]
id: PATO:0000136
name: closure
namespace: quality
def: "A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent." [PATOC:CJM, PATOC:GVG]
subset: attribute_slim
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000141
name: structure
namespace: quality
alt_id: PATO:0001452
def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG]
subset: attribute_slim
synonym: "conformation" BROAD [VT:1000738]
synonym: "relational structural quality" EXACT []
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000150
name: texture
namespace: quality
def: "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0000051 ! morphology

[Term]
id: PATO:0000261
name: maturity
namespace: quality
def: "A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development." [Merriam-Webster:Merriam-Webster]
subset: attribute_slim
is_a: PATO:0001995 ! organismal quality

[Term]
id: PATO:0000365
name: down
namespace: quality
def: "A directional quality inhering in a bearer by virtue of the bearer's direction from a higher to a lower point." []
def: "A directional quality inhering in a bearer by virtue of the bearer's direction from a higher to a lower point." [PATOC:GVG]
subset: value_slim
is_a: PATO:0000039 ! direction
property_value: RO:0002604 PATO:0000370

[Term]
id: PATO:0000374
name: increased distance
namespace: quality
def: "A distance which is greater relative to the normal or average." [PATOC:GVG]
subset: relational_slim
subset: value_slim
synonym: "long distance" RELATED []
is_a: PATO:0000040 ! distance
is_a: PATO:0002305 ! increased object quality
intersection_of: PATO:0000040 ! distance
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0000375

[Term]
id: PATO:0000375
name: decreased distance
namespace: quality
def: "A distance which is lesser relative to the normal or average." [PATOC:GVG]
subset: relational_slim
subset: value_slim
synonym: "short distance" RELATED []
is_a: PATO:0000040 ! distance
is_a: PATO:0002303 ! decreased object quality
intersection_of: PATO:0000040 ! distance
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000374

[Term]
id: PATO:0000402
name: branched
namespace: quality
def: "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." [WordNet:WordNet]
subset: cell_quality
subset: mpath_slim
subset: value_slim
synonym: "ramified" EXACT []
synonym: "ramiform" EXACT []
is_a: PATO:0002009 ! branchiness
property_value: RO:0002604 PATO:0000414

[Term]
id: PATO:0000404
name: coiled
namespace: quality
alt_id: PATO:0001363
def: "A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals)." [WordNet:WordNet]
subset: cell_quality
subset: mpath_slim
subset: value_slim
synonym: "helical" RELATED []
synonym: "helicoid" RELATED []
synonym: "helicoidal" RELATED []
synonym: "helix-shaped" RELATED []
synonym: "spiral" EXACT []
is_a: PATO:0001794 ! coiling
property_value: RO:0002604 PATO:0000415

[Term]
id: PATO:0000407
name: flat
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature." [web:http\://www.merriam-webster.com/]
subset: cell_quality
subset: mpath_slim
subset: value_slim
synonym: "plate-like" RELATED []
is_a: PATO:0002254 ! flattened

[Term]
id: PATO:0000411
name: circular
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com]
subset: cell_quality
subset: mpath_slim
subset: value_slim
synonym: "round" RELATED []
synonym: "rounded" RELATED []
is_a: PATO:0000947 ! elliptic

[Term]
id: PATO:0000461
name: normal
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG]
subset: abnormal_slim
subset: mpath_slim
subset: value_slim
synonym: "average" RELATED []
is_a: PATO:0000068 ! qualitative
property_value: RO:0002604 PATO:0000460

[Term]
id: PATO:0000467
name: present
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's existence." [PATOC:GVG]
subset: absent_slim
subset: value_slim
synonym: "present in organism" RELATED []
is_a: PATO:0000070 ! amount
property_value: RO:0002604 PATO:0000462

[Term]
id: PATO:0000470
name: increased amount
namespace: quality
alt_id: PATO:0000420
alt_id: PATO:0000650
def: "An amount which is relatively high." [PATOC:GVG]
subset: value_slim
synonym: "accessory" RELATED []
synonym: "increased" RELATED []
synonym: "increased number" EXACT []
synonym: "present in greater numbers in organism" EXACT []
synonym: "supernumerary" EXACT []
is_a: PATO:0000467 ! present
is_a: PATO:0002300 ! increased quality
intersection_of: PATO:0000070 ! amount
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0001997

[Term]
id: PATO:0000573
name: increased length
namespace: quality
def: "A length quality which is relatively large." [PATOC:GVG]
subset: value_slim
synonym: "long" EXACT []
is_a: PATO:0000122 ! length
is_a: PATO:0000586 ! increased size
intersection_of: PATO:0000122 ! length
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0000574

[Term]
id: PATO:0000574
name: decreased length
namespace: quality
def: "A length quality which is relatively small." [PATOC:GVG]
subset: value_slim
synonym: "short" EXACT []
synonym: "shortened" RELATED []
synonym: "stubby" RELATED []
is_a: PATO:0000122 ! length
is_a: PATO:0000587 ! decreased size
intersection_of: PATO:0000122 ! length
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000573

[Term]
id: PATO:0000586
name: increased size
namespace: quality
alt_id: PATO:0001202
def: "A size quality which is relatively high." [PATOC:GVG]
subset: value_slim
synonym: "big" RELATED []
synonym: "enlarged" RELATED []
synonym: "expanded" RELATED []
synonym: "great" RELATED []
synonym: "large" RELATED []
is_a: PATO:0000117 ! size
is_a: PATO:0002305 ! increased object quality
intersection_of: PATO:0000117 ! size
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0000587

[Term]
id: PATO:0000587
name: decreased size
namespace: quality
def: "A size quality which is relatively low." [PATOC:GVG]
subset: value_slim
synonym: "hypoplasia" NARROW []
synonym: "reduced" RELATED []
synonym: "small" RELATED []
synonym: "tiny" RELATED []
synonym: "underdeveloped" NARROW []
is_a: PATO:0000117 ! size
is_a: PATO:0002303 ! decreased object quality
intersection_of: PATO:0000117 ! size
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000586

[Term]
id: PATO:0000591
name: increased thickness
namespace: quality
def: "A thickness which is relatively high." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
synonym: "high thickness" EXACT []
synonym: "stout" EXACT []
synonym: "thick" RELATED []
synonym: "thickened" EXACT []
is_a: PATO:0000586 ! increased size
is_a: PATO:0000915 ! thickness
intersection_of: PATO:0000915 ! thickness
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0000592

[Term]
id: PATO:0000592
name: decreased thickness
namespace: quality
def: "A thickness which is relatively low." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
synonym: "low thickness" EXACT []
synonym: "slender" RELATED []
synonym: "thin" RELATED []
is_a: PATO:0000587 ! decreased size
is_a: PATO:0000915 ! thickness
intersection_of: PATO:0000915 ! thickness
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000591

[Term]
id: PATO:0000599
name: decreased width
namespace: quality
def: "A width which is relatively small." [PATOC:GVG]
subset: value_slim
synonym: "narrow" RELATED []
is_a: PATO:0000587 ! decreased size
is_a: PATO:0000921 ! width
intersection_of: PATO:0000921 ! width
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000600

[Term]
id: PATO:0000600
name: increased width
namespace: quality
def: "A width which is relatively large." [PATOC:GVG]
subset: value_slim
synonym: "broad" RELATED []
synonym: "wide" RELATED []
synonym: "wide/broad" RELATED []
is_a: PATO:0000586 ! increased size
is_a: PATO:0000921 ! width
intersection_of: PATO:0000921 ! width
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0000599

[Term]
id: PATO:0000608
name: closed
namespace: quality
def: "A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view." [answers.com:answers.com]
subset: value_slim
synonym: "blocked" RELATED []
is_a: PATO:0000136 ! closure
property_value: RO:0002604 PATO:0000610

[Term]
id: PATO:0000915
name: thickness
namespace: quality
def: "A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width." [WordNet:WordNet]
comment: Thickness often refers to the smallest 1-D extent compared to the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
subset: attribute_slim
subset: scalar_slim
is_a: PATO:0001708 ! 1-D extent
property_value: seeAlso "https://github.com/pato-ontology/pato/issues/337" xsd:string

[Term]
id: PATO:0000921
name: width
namespace: quality
def: "A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite." [PATOC:GVG]
comment: Width often refers to the dimension that is greater than the extent in only one of the other two orthogonal dimensions, however, this is not always true. See https://github.com/pato-ontology/pato/issues/337 for full discussion.
subset: attribute_slim
subset: scalar_slim
synonym: "breadth" RELATED []
is_a: PATO:0001708 ! 1-D extent
property_value: seeAlso "https://github.com/pato-ontology/pato/issues/337" xsd:string

[Term]
id: PATO:0000944
name: sharpness
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point." [PATOC:GVG]
subset: attribute_slim
subset: cell_quality
synonym: "apiculate" EXACT []
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0000947
name: elliptic
namespace: quality
def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG]
subset: cell_quality
subset: mpath_slim
subset: value_slim
synonym: "ellipse-shaped" EXACT []
synonym: "ellipsoid" EXACT []
synonym: "elliptical" EXACT []
synonym: "oval" RELATED []
synonym: "ovoid" RELATED []
is_a: PATO:0002318 ! superelliptic

[Term]
id: PATO:0000957
name: opacity
namespace: quality
def: "An optical quality which obtains by virtue of the ability of the bearer to absorb visible light." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0001300 ! optical quality

[Term]
id: PATO:0000963
name: opaque
namespace: quality
def: "A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
synonym: "clouding" RELATED []
synonym: "cloudy" RELATED []
synonym: "non-transparent" EXACT []
is_a: PATO:0000957 ! opacity
property_value: RO:0002604 PATO:0000964

[Term]
id: PATO:0000964
name: transparent
namespace: quality
def: "A optical quality inhering in a bearer by virtue of the bearer's lacking opacity." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
synonym: "clear" EXACT []
synonym: "hyaline" EXACT []
is_a: PATO:0000957 ! opacity
property_value: RO:0002604 PATO:0000963

[Term]
id: PATO:0000965
name: symmetry
namespace: quality
def: "A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0000060 ! spatial pattern

[Term]
id: PATO:0000973
name: porosity
namespace: quality
def: "A structure quality inhering in a bearer by virtue of the bearer's disposition to admit the passage of gas or liquid through pores or interstices." [PATOC:GVG]
subset: attribute_slim
subset: disposition_slim
subset: scalar_slim
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0000984
name: porous
namespace: quality
def: "A porosity quality inhering in a bearer by virtue of the bearer's being capable of admitting the passage of gas or liquid through pores or interstices." [PATOC:GVG]
subset: disposition_slim
subset: value_slim
is_a: PATO:0000973 ! porosity
property_value: RO:0002604 PATO:0000985

[Term]
id: PATO:0000992
name: viscosity
namespace: quality
def: "A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow." [PATOC:GVG]
subset: attribute_slim
subset: disposition_slim
is_a: PATO:0001548 ! quality of a liquid

[Term]
id: PATO:0000998
name: viscous
namespace: quality
def: "A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity." [PATOC:GVG]
subset: disposition_slim
subset: mpath_slim
subset: value_slim
is_a: PATO:0000992 ! viscosity

[Term]
id: PATO:0001018
name: physical quality
namespace: quality
alt_id: PATO:0002079
def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG]
subset: attribute_slim
synonym: "relational physical quality" EXACT []
xref: Wikipedia:Physical_property
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0001031
name: elasticity
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster]
subset: attribute_slim
subset: disposition_slim
subset: scalar_slim
is_a: PATO:0001018 ! physical quality

[Term]
id: PATO:0001154
name: elongated
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width." [WordNet:WordNet]
subset: value_slim
is_a: PATO:0000052 ! shape
property_value: RO:0002604 PATO:0002364

[Term]
id: PATO:0001171
name: elastic
namespace: quality
def: "An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way." [merriam-webster:merriam-webster]
subset: disposition_slim
subset: mpath_slim
subset: value_slim
is_a: PATO:0001031 ! elasticity
property_value: RO:0002604 PATO:0001172

[Term]
id: PATO:0001185
name: larval
namespace: quality
def: "A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis." [Wikipedia:http\://en.wikipedia.org/wiki/Larval]
subset: value_slim
is_a: PATO:0000261 ! maturity

[Term]
id: PATO:0001190
name: juvenile
namespace: quality
def: "A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed." [thefreedictionary.com:thefreedictionary.com]
subset: mpath_slim
subset: value_slim
is_a: PATO:0000261 ! maturity

[Term]
id: PATO:0001199
name: linear
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel." [ISBN:0881923214]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001241
name: physical object quality
namespace: quality
alt_id: PATO:0001237
alt_id: PATO:0001238
def: "A quality which inheres in a continuant." [PATOC:GVG]
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.
synonym: "monadic quality of a continuant" EXACT []
synonym: "monadic quality of an object" NARROW []
synonym: "monadic quality of continuant" NARROW []
synonym: "multiply inhering quality of a physical entity" EXACT []
synonym: "quality of a continuant" EXACT []
synonym: "quality of a single physical entity" EXACT []
synonym: "quality of an object" EXACT []
synonym: "quality of continuant" EXACT []
xref: snap:Quality
is_a: BFO:0000019 ! quality
is_a: PATO:0000001 ! quality
property_value: IAO:0000111 "physical object quality" xsd:string
property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl

[Term]
id: PATO:0001300
name: optical quality
namespace: quality
def: "An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0070060 ! quality of interaction of a substance with electromagnetic radiation

[Term]
id: PATO:0001355
name: convex
namespace: quality
def: "A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere." [PATOC:GVG]
subset: cell_quality
subset: value_slim
is_a: PATO:0002005 ! concavity
property_value: RO:0002604 PATO:0001857

[Term]
id: PATO:0001369
name: raised
namespace: quality
def: "A shape quality inhering in a colony by virtue of the bearer's appearing above the medium surface with terraced edges." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001374
name: ploidy
namespace: quality
def: "A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism." [Wikipedia:http\://en.wikipedia.org/wiki/Ploidy]
subset: attribute_slim
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001375
name: haploid
namespace: quality
def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Haploid]
subset: cell_quality
subset: value_slim
is_a: PATO:0001393 ! euploid

[Term]
id: PATO:0001377
name: polyploid
namespace: quality
def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Polyploid]
subset: cell_quality
subset: value_slim
is_a: PATO:0001393 ! euploid

[Term]
id: PATO:0001393
name: euploid
namespace: quality
def: "A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes." [Wikipedia:http\://en.wikipedia.org/wiki/Euploid]
subset: cell_quality
subset: value_slim
is_a: PATO:0001374 ! ploidy

[Term]
id: PATO:0001394
name: diploid
namespace: quality
def: "A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father." [Wikipedia:http\://en.wikipedia.org/wiki/Diploid]
comment: The exact number may be one or two different from the 2n number and still be classified as diploidy (although with aneuploidy). Nearly all mammals are diploid organisms, although all individuals have some small fraction of cells that are polyploidy.
subset: cell_quality
subset: value_slim
is_a: PATO:0001393 ! euploid

[Term]
id: PATO:0001396
name: cellular quality
namespace: quality
def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG]
is_a: PATO:0070044 ! anatomical structure quality

[Term]
id: PATO:0001397
name: cellular potency
namespace: quality
def: "A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types." [PATOC:GVG]
subset: attribute_slim
subset: disposition_slim
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001400
name: unipotent
namespace: quality
def: "A cellular potency that is the capacity to produce only one differentiated cell type." [Wikipedia:http\://en.wikipedia.org/wiki/Unipotent]
comment: Unipotent cells have the quality of self-renewal which distinguishes them from non-stem cells.
subset: cell_quality
subset: disposition_slim
subset: value_slim
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001401
name: oligopotent
namespace: quality
def: "A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity." [PATOC:MAH]
comment: Less potent than multipotent, often thought of as precursor or progenitor cell status.
subset: cell_quality
subset: disposition_slim
subset: value_slim
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001402
name: multipotent
namespace: quality
def: "A cellular potency that is the capacity to form multiple differentiated cell types." [Wikipedia:http\://en.wikipedia.org/wiki/Multipotent]
subset: cell_quality
subset: disposition_slim
subset: value_slim
is_a: PATO:0001397 ! cellular potency

[Term]
id: PATO:0001404
name: nucleate quality
namespace: quality
def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001405
name: anucleate
namespace: quality
def: "A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus." [Biology-online:Biology-online]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0001404 ! nucleate quality

[Term]
id: PATO:0001406
name: binucleate
namespace: quality
def: "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." [Biology-online:Biology-online]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0001908 ! multinucleate

[Term]
id: PATO:0001407
name: mononucleate
namespace: quality
def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0002505 ! nucleated

[Term]
id: PATO:0001408
name: ciliatedness
namespace: quality
def: "A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body." [Wikipedia:http\://en.wikipedia.org/wiki/Ciliated]
subset: cell_quality
subset: value_slim
is_a: PATO:0001396 ! cellular quality

[Term]
id: PATO:0001410
name: striated
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel." [Biology-online:Biology-online]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001419
name: sharp
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge." [PATOC:GVG]
subset: cell_quality
subset: value_slim
is_a: PATO:0000944 ! sharpness

[Term]
id: PATO:0001500
name: tapered
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end." [WordNet:WordNet]
subset: cell_quality
subset: value_slim
synonym: "taper" EXACT []
is_a: PATO:0001419 ! sharp

[Term]
id: PATO:0001501
name: immature
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development." [Merriam-Webster:Merriam-Webster]
subset: value_slim
synonym: "underdeveloped" RELATED []
is_a: PATO:0000261 ! maturity
property_value: RO:0002604 PATO:0001701

[Term]
id: PATO:0001543
name: flexibility
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking." [merriam-webster:merriam-webster]
subset: attribute_slim
subset: disposition_slim
is_a: PATO:0001546 ! quality of a solid

[Term]
id: PATO:0001546
name: quality of a solid
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/soliddefinition.htm]
subset: attribute_slim
synonym: "solidity" EXACT []
is_a: PATO:0002198 ! quality of a substance

[Term]
id: PATO:0001547
name: quality of a gas
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape." [Chemistry:http\://chemistry.about.com/od/chemistryglossary/a/gasdefinition.htm, PATOC:GVG]
subset: attribute_slim
synonym: "gaseous" EXACT []
is_a: PATO:0002198 ! quality of a substance

[Term]
id: PATO:0001548
name: quality of a liquid
namespace: quality
def: "A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape." [url:http\://www.chemistry-dictionary.com/definition/liquid.php]
subset: attribute_slim
synonym: "liquidity" EXACT []
is_a: PATO:0002198 ! quality of a substance

[Term]
id: PATO:0001555
name: has number of
namespace: quality
def: "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." [PATOC:CJM]
subset: attribute_slim
subset: relational_slim
synonym: "cardinality" RELATED []
synonym: "extra or missing physical or functional parts" EXACT []
synonym: "has or lacks parts of type" EXACT []
synonym: "mereological quality" EXACT []
synonym: "number" RELATED []
synonym: "number of" EXACT []
xref: OBO_REL:has_part
is_a: PATO:0000070 ! amount

[Term]
id: PATO:0001571
name: dilated
namespace: quality
def: "A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions." [WordNet:WordNet]
def: "A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions. [database_cross_reference: WordNet:WordNet]" []
subset: mpath_slim
subset: value_slim
is_a: PATO:0000586 ! increased size

[Term]
id: PATO:0001573
name: isometrical
namespace: quality
def: "A symmetry quality inhering in a bearer by virtue of the bearer's having equal dimensions or measurements." [WordNet:WordNet]
def: "A symmetry quality inhering in a bearer by virtue of the bearer's having equal dimensions or measurements." []
subset: cell_quality
subset: value_slim
is_a: PATO:0000965 ! symmetry

[Term]
id: PATO:0001579
name: contractility
namespace: quality
def: "A physical quality that is the ability to contract or shrink." [WordNet:WordNet]
subset: attribute_slim
subset: disposition_slim
subset: scalar_slim
is_a: PATO:0001018 ! physical quality

[Term]
id: PATO:0001591
name: curvature
namespace: quality
def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet]
subset: attribute_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001690
name: contractile
namespace: quality
def: "A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted." [PATOC:GVG]
comment: This refers to the disposition of the bearer.
subset: disposition_slim
subset: value_slim
is_a: PATO:0001579 ! contractility
property_value: RO:0002604 PATO:0001691

[Term]
id: PATO:0001708
name: 1-D extent
namespace: quality
def: "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." [PATOC:GVG]
subset: attribute_slim
synonym: "1-D size" EXACT []
is_a: PATO:0000117 ! size

[Term]
id: PATO:0001735
name: liquid configuration
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids." [PATOC:GVG]
synonym: "liquid" EXACT []
is_a: PATO:0001548 ! quality of a liquid

[Term]
id: PATO:0001736
name: solid configuration
namespace: quality
def: "A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids." [PATOC:GVG]
subset: value_slim
synonym: "solid" EXACT []
is_a: PATO:0001546 ! quality of a solid

[Term]
id: PATO:0001748
name: invaginated
namespace: quality
def: "A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave." [PATOC:GVG]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0001857 ! concave

[Term]
id: PATO:0001794
name: coiling
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops." [Online_Dictionary:Online_Dictionary]
subset: attribute_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0001795
name: increased coiling
namespace: quality
def: "A coiling which is relatively high." [PATOC:GVG]
subset: cell_quality
subset: value_slim
synonym: "high coiling" EXACT []
is_a: PATO:0000404 ! coiled
is_a: PATO:0002305 ! increased object quality
intersection_of: PATO:0000404 ! coiled
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0001796

[Term]
id: PATO:0001796
name: decreased coiling
namespace: quality
def: "A coiling which is relatively low." [PATOC:GVG]
subset: cell_quality
subset: value_slim
synonym: "low coiling" EXACT []
is_a: PATO:0000404 ! coiled
is_a: PATO:0002303 ! decreased object quality
intersection_of: PATO:0000404 ! coiled
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0001795

[Term]
id: PATO:0001847
name: constricted
namespace: quality
alt_id: PATO:0001837
def: "A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically." [WordNet:WordNet]
subset: value_slim
synonym: "stenosis" EXACT []
synonym: "stenotic" EXACT []
synonym: "stricture" EXACT []
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0001857
name: concave
namespace: quality
def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet]
subset: cell_quality
subset: value_slim
is_a: PATO:0002005 ! concavity
property_value: RO:0002604 PATO:0001355

[Term]
id: PATO:0001873
name: cylindrical
namespace: quality
alt_id: PATO:0001203
def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section." [PATOC:MAH]
subset: cell_quality
subset: value_slim
synonym: "rod-like" EXACT []
synonym: "rod-shaped" EXACT []
synonym: "tubulate" NARROW []
is_a: PATO:0002007 ! convex 3-D shape
relationship: has_cross_section PATO:0000411 ! circular

[Term]
id: PATO:0001901
name: back
namespace: quality
def: "A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the north when it faces south." []
def: "A directional quality inhering in a bearer by virtue of the bearer's direction that is similar to the direction of an object to the north when it faces south." [PATOC:GVG]
subset: value_slim
is_a: PATO:0000039 ! direction
property_value: RO:0002604 PATO:0001900

[Term]
id: PATO:0001908
name: multinucleate
namespace: quality
def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
is_a: PATO:0002505 ! nucleated

[Term]
id: PATO:0001987
name: saccular
namespace: quality
def: "A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance." [PATOC:MAH]
subset: value_slim
synonym: "sacular" EXACT []
is_a: PATO:0002014 ! structure, cavities

[Term]
id: PATO:0001992
name: cellularity
namespace: quality
def: "An organismal quality inhering in a bearer by virtue of the bearer's consisting cells." [PATOC:GVG]
subset: attribute_slim
subset: scalar_slim
is_a: PATO:0001995 ! organismal quality

[Term]
id: PATO:0001993
name: multicellular
namespace: quality
def: "A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell." [PATOC:GVG]
subset: value_slim
is_a: PATO:0001992 ! cellularity

[Term]
id: PATO:0001995
name: organismal quality
namespace: quality
def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM]
is_a: PATO:0001241 ! physical object quality

[Term]
id: PATO:0001997
name: decreased amount
namespace: quality
alt_id: PATO:0000419
alt_id: PATO:0000468
def: "An amount which is relatively low." [PATOC:GVG]
subset: value_slim
synonym: "decreased" RELATED []
synonym: "decreased number" EXACT []
synonym: "present in fewer numbers in organism" EXACT []
synonym: "reduced" RELATED []
synonym: "subnumerary" RELATED []
is_a: PATO:0000467 ! present
is_a: PATO:0002301 ! decreased quality
intersection_of: PATO:0000070 ! amount
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0000470

[Term]
id: PATO:0002005
name: concavity
namespace: quality
def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH]
subset: attribute_slim
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0002006
name: 2-D shape
namespace: quality
def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM]
subset: attribute_slim
synonym: "2-D projection" RELATED []
synonym: "cross-sectional" RELATED []
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0002007
name: convex 3-D shape
namespace: quality
def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM]
comment: Use this term or an is_a child of this term when the entire shape of the object is known.
subset: attribute_slim
xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png
is_a: PATO:0002266 ! 3-D shape
relationship: has_cross_section PATO:0002006 ! 2-D shape
property_value: RO:0002604 PATO:0002008

[Term]
id: PATO:0002009
name: branchiness
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." [PATOC:MAH]
subset: attribute_slim
subset: cell_quality
is_a: PATO:0000052 ! shape

[Term]
id: PATO:0002014
name: structure, cavities
namespace: quality
def: "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0002021
name: conical
namespace: quality
def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers)." [Wikipedia:http\://en.wikipedia.org/wiki/Cone_(geometry)]
subset: value_slim
synonym: "cone-shaped" EXACT []
xref: Image:http\://upload.wikimedia.org/wikipedia/commons/d/d2/Cone_3d.png
is_a: PATO:0002007 ! convex 3-D shape

[Term]
id: PATO:0002039
name: biconcave
namespace: quality
def: "A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces." [PATOC:GVG]
subset: value_slim
is_a: PATO:0001857 ! concave
property_value: RO:0002604 PATO:0002040

[Term]
id: PATO:0002045
name: dendritic
namespace: quality
def: "A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure." [PATOC:cvs]
subset: value_slim
synonym: "dendriform" EXACT []
synonym: "dendroid" EXACT []
synonym: "dendroidal" EXACT []
is_a: PATO:0000402 ! branched
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2009-02-15T08:11:41Z

[Term]
id: PATO:0002078
name: hollow
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within." [url:http\://www.merriam-webster.com/dictionary/hollow]
subset: value_slim
is_a: PATO:0002014 ! structure, cavities
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2009-09-18T02:19:20Z

[Term]
id: PATO:0002094
name: basophilic
namespace: quality
def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions." [PATOC:GVG]
subset: disposition_slim
subset: mpath_slim
subset: value_slim
is_a: PATO:0070045 ! anatomical histological quality
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2009-10-05T12:05:23Z

[Term]
id: PATO:0002124
name: laminar
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
is_a: PATO:0000141 ! structure
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2009-10-06T04:37:14Z

[Term]
id: PATO:0002198
name: quality of a substance
namespace: quality
def: "A quality inhering in a bearer by virtue of its constitution." [PATOC:GVG]
subset: attribute_slim
is_a: PATO:0001018 ! physical quality
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-03-15T04:35:27Z

[Term]
id: PATO:0002219
name: fan-shaped
namespace: quality
def: "A quality inhering in a bearer that is shaped in the form of a fan." [thefreedictionary:http\://www.thefreedictionary.com/fan-shaped]
subset: value_slim
synonym: "fan-like" EXACT []
is_a: PATO:0002006 ! 2-D shape
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-07-09T01:43:42Z

[Term]
id: PATO:0002226
name: subcylindrical
namespace: quality
def: "A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical." [url:http\://www.thefreedictionary.com/Subcylindrical]
subset: value_slim
is_a: PATO:0001873 ! cylindrical
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-07-13T04:22:30Z

[Term]
id: PATO:0002228
name: acuminate
namespace: quality
def: "A tapered shape quality inhering in a bearer by virtue of the bearer's tapering gradually to a sharp point." [url:http\://www.thefreedictionary.com/acuminate]
subset: value_slim
is_a: PATO:0001500 ! tapered
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-07-15T09:03:18Z

[Term]
id: PATO:0002254
name: flattened
namespace: quality
def: "A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane." [PATOC:CVS]
comment: Becoming flat but not necessarily completely flat.
subset: value_slim
synonym: "compressed" RELATED []
is_a: PATO:0001591 ! curvature
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-08-16T03:59:34Z

[Term]
id: PATO:0002255
name: grooved
namespace: quality
def: "Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels." [PATOC:JE]
subset: value_slim
synonym: "channeled" RELATED []
synonym: "creased" RELATED []
is_a: PATO:0000150 ! texture
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-09-01T10:27:48Z

[Term]
id: PATO:0002258
name: pointed
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's having a point." [PATOC:http\://www.merriam-webster.com/dictionary/pointed]
def: "A shape quality inhering in a bearer by virtue of the bearer's having a point." []
subset: value_slim
is_a: PATO:0001419 ! sharp
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-09-08T03:15:16Z

[Term]
id: PATO:0002266
name: 3-D shape
namespace: quality
def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON]
is_a: PATO:0000052 ! shape
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2010-10-05T12:31:16Z

[Term]
id: PATO:0002287
name: increased elasticity
namespace: quality
def: "An elasticity which is relatively high." [PATOC:GVG]
subset: value_slim
is_a: PATO:0001171 ! elastic
is_a: PATO:0002305 ! increased object quality
intersection_of: PATO:0001171 ! elastic
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0002288
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-03-30T11:50:21Z

[Term]
id: PATO:0002288
name: decreased elasticity
namespace: quality
def: "An elasticity which is relatively low." [PATOC:GVG]
subset: value_slim
is_a: PATO:0001171 ! elastic
is_a: PATO:0002303 ! decreased object quality
intersection_of: PATO:0001171 ! elastic
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0002287
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-03-30T11:50:39Z

[Term]
id: PATO:0002299
name: tubular
namespace: quality
def: "A cylindrical shape that is hollow." [PATOC:GVG]
synonym: "tube like" EXACT []
synonym: "tube-shaped" EXACT []
synonym: "tubulate" EXACT []
is_a: PATO:0001873 ! cylindrical
is_a: PATO:0002078 ! hollow
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-06-08T06:33:50Z

[Term]
id: PATO:0002300
name: increased quality
namespace: quality
def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG]
is_a: PATO:0000069 ! deviation (from_normal)
intersection_of: PATO:0000001 ! quality
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
relationship: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0002301
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-06-16T06:39:43Z

[Term]
id: PATO:0002301
name: decreased quality
namespace: quality
def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG]
is_a: PATO:0000069 ! deviation (from_normal)
intersection_of: PATO:0000001 ! quality
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
relationship: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0002300
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-06-16T06:40:15Z

[Term]
id: PATO:0002303
name: decreased object quality
namespace: quality
def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG]
is_a: PATO:0001241 ! physical object quality
is_a: PATO:0002301 ! decreased quality
intersection_of: PATO:0001241 ! physical object quality
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0002305
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-06-16T06:51:54Z

[Term]
id: PATO:0002305
name: increased object quality
namespace: quality
def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG]
is_a: PATO:0001241 ! physical object quality
is_a: PATO:0002300 ! increased quality
intersection_of: PATO:0001241 ! physical object quality
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal
property_value: RO:0002604 PATO:0002303
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-06-16T06:54:01Z

[Term]
id: PATO:0002309
name: fiber shaped
namespace: quality
def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter." [PATOC:DC]
comment: Note that a fiber shaped object may take any circuitous or straight path through space (think of a length of string or rope).
subset: value_slim
is_a: PATO:0002226 ! subcylindrical
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-09-09T04:50:10Z

[Term]
id: PATO:0002318
name: superelliptic
namespace: quality
def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse]
synonym: "Lamé curve" EXACT []
is_a: PATO:0002006 ! 2-D shape
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2011-10-12T12:45:16Z

[Term]
id: PATO:0002418
name: acidophilic
namespace: quality
def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions." [PATOC:GVG]
comment: Eosin stains acidophilic structures, hence eosinophilic is the same as acidophilic.
subset: mpath_slim
subset: value_slim
synonym: "eosinophilic" EXACT []
is_a: PATO:0070045 ! anatomical histological quality
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2012-12-17T03:01:19Z

[Term]
id: PATO:0002422
name: acinar
namespace: quality
def: "Pertaining to the individual parts making up an aggregate fruit like a many-lobed \"berry,\" such as a raspberry." [wikipedia:https\://en.wikipedia.org/wiki/Acinus]
comment: Acinus is Latin for berry.
subset: mpath_slim
subset: value_slim
is_a: PATO:0000141 ! structure
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2012-12-17T03:11:10Z

[Term]
id: PATO:0002462
name: collagenous
namespace: quality
def: "A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen." [PATOC:WD]
subset: value_slim
is_a: PATO:0000025 ! composition
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-09-15T11:34:15Z

[Term]
id: PATO:0002468
name: distensible
namespace: quality
def: "A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching." [PATOC:WD]
subset: value_slim
is_a: PATO:0015008 ! distensibility
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-09-15T11:48:26Z

[Term]
id: PATO:0002478
name: transversely striated
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer." [PATOC:DS]
subset: cell_quality
subset: mpath_slim
subset: value_slim
is_a: PATO:0001410 ! striated
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-09-15T12:29:15Z

[Term]
id: PATO:0002505
name: nucleated
namespace: quality
def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG]
subset: mpath_slim
subset: value_slim
is_a: PATO:0001404 ! nucleate quality
property_value: term:contributor https://orcid.org/0000-0002-2061-091X
creation_date: 2013-10-21T05:44:34Z

[Term]
id: PATO:0002539
name: ring shaped
namespace: quality
def: "A shape quality inhering in a bearer by virtue of the bearer's having a shape like a ring (a circular shape enclosing a space)." [PATOC:WD]
subset: value_slim
synonym: "annular" EXACT []
synonym: "ring-shaped" EXACT []
is_a: PATO:0000947 ! elliptic
property_value: term:contributor https://orcid.org/0000-0003-3162-7490
creation_date: 2014-08-12T12:01:56Z

[Term]
id: PATO:0010001
name: disconnected
namespace: quality
def: "A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other." [GOC:dos]
is_a: PATO:0000141 ! structure
property_value: term:contributor https://orcid.org/0000-0002-7073-9172
creation_date: 2014-12-12T08:43:17Z

[Term]
id: PATO:0015006
name: polymeric
namespace: quality
def: "A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array." [GOC:DOS, https://github.com/pato-ontology/pato/issues/78]
comment: A complete coverage of this domain would subclasses homopolymeric, copolymeric, crystalline.
subset: value_slim
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0015008
name: distensibility
namespace: quality
def: "A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen." [GOC:CJM]
subset: attribute_slim
is_a: PATO:0000141 ! structure

[Term]
id: PATO:0015024
name: increased porosity
namespace: quality
def: "An increase in porosity." [https://github.com/pato-ontology/pato/issues/110]
subset: value_slim
is_a: PATO:0000973 ! porosity
is_a: PATO:0002305 ! increased object quality
intersection_of: PATO:0000973 ! porosity
intersection_of: RO:0015007 PATO:0000461 ! increased in magnitude relative to normal

[Term]
id: PATO:0015025
name: decreased porosity
namespace: quality
def: "An decrease in porosity." [https://github.com/pato-ontology/pato/issues/110]
subset: value_slim
is_a: PATO:0000973 ! porosity
is_a: PATO:0002303 ! decreased object quality
intersection_of: PATO:0000973 ! porosity
intersection_of: RO:0015008 PATO:0000461 ! decreased in magnitude relative to normal
property_value: RO:0002604 PATO:0015024

[Term]
id: PATO:0040024
name: bilaterally paired
namespace: quality
def: "The bearer of this quality has_part n=2 of the indicated entity type, where n is unpaired for a comparable organism." [https://orcid.org/0000-0003-3162-7490]
synonym: "paired" BROAD []
is_a: PATO:0000467 ! present
property_value: term:contributor https://orcid.org/0000-0001-5208-3432

[Term]
id: PATO:0040072
name: high nuclear/cytoplasmic ratio
namespace: quality
def: "A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio." [http://lymerick.net/blood-cells.pdf, Wikipedia:NC_ratio&oldid=931936284]
comment: A high nuclear/cytolasmic ratio is 70% or higher.
synonym: "high N:C ratio" EXACT []
is_a: PATO:0001396 ! cellular quality
created_by: http://orcid.org/0000-0001-5208-3432

[Term]
id: PATO:0070044
name: anatomical structure quality
namespace: quality
def: "A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components." []
is_a: PATO:0001241 ! physical object quality
created_by: http://orcid.org/0000-0001-7258-9596

[Term]
id: PATO:0070045
name: anatomical histological quality
namespace: quality
def: "A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes." []
is_a: PATO:0070044 ! anatomical structure quality
created_by: http://orcid.org/0000-0001-7258-9596

[Term]
id: PATO:0070046
name: neutrophillic
namespace: quality
def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain." [GOC:add]
is_a: PATO:0070045 ! anatomical histological quality
created_by: http://orcid.org/0000-0001-7258-9596

[Term]
id: PATO:0070047
name: polychromatophilic
namespace: quality
def: "An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions." [GOC:add]
is_a: PATO:0070045 ! anatomical histological quality
created_by: http://orcid.org/0000-0001-7258-9596

[Term]
id: PATO:0070060
name: quality of interaction of a substance with electromagnetic radiation
namespace: quality
def: "A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength." [https://orcid.org/0000-0002-5111-7263]
subset: attribute_slim
is_a: PATO:0002198 ! quality of a substance

[Term]
id: PATO:0103000
name: quantitative
namespace: quality
def: "A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value." [https://libguides.macalester.edu/c.php?g=527786&p=3608639, https://www.nnlm.gov/guides/data-glossary/quantitative-data]
is_a: PATO:0000001 ! quality
created_by: https://orcid.org/0000-0001-8314-2140

[Term]
id: PR:000000001
name: protein
namespace: protein
def: "An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB]
comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].
synonym: "native protein" NARROW [IEDB:BP]
synonym: "natural protein" EXACT [PRO:DAN]
is_a: PR:000018263 ! amino acid chain
is_a: PR:000050567 ! protein-containing material entity
intersection_of: PR:000018263 ! amino acid chain
intersection_of: has_gene_template SO:0000704 ! gene
intersection_of: output_of GO:0006412 ! translation
relationship: has_gene_template SO:0000704 ! gene
relationship: output_of GO:0006412 ! translation

[Term]
id: PR:000001002
name: CD19 molecule
namespace: protein
def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510]
comment: Category=gene. Requested by=CL.
synonym: "B-lymphocyte surface antigen B4" EXACT []
synonym: "CD19" EXACT PRO-short-label [PRO:DNx]
synonym: "differentiation antigen CD19" EXACT []
synonym: "T-cell surface antigen Leu-12" EXACT []
xref: IUPHARobj:2764
xref: PIRSF:PIRSF016630
is_a: PR:000000001 ! protein

[Term]
id: PR:000001003
name: CD34 molecule
namespace: protein
def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [PMID:16720896, PMID:8983065]
comment: Category=gene. Requested by=CL.
synonym: "CD34" EXACT PRO-short-label [PRO:DNx]
synonym: "hematopoietic progenitor cell antigen CD34" EXACT []
xref: PIRSF:PIRSF028749
is_a: PR:000000001 ! protein

[Term]
id: PR:000001004
name: CD4 molecule
namespace: protein
def: "A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence." [PMID:15326605]
comment: Category=gene. Requested by=CL.
synonym: "CD4" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell differentiation antigen L3T4" EXACT []
synonym: "T-cell surface antigen T4/Leu-3" EXACT []
synonym: "T-cell surface glycoprotein CD4" EXACT []
xref: PIRSF:PIRSF001977
is_a: PR:000000001 ! protein

[Term]
id: PR:000001005
name: integrin alpha with A domain
namespace: protein
def: "An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage." [PIRSF:PIRSF002497]
comment: Category=family.
synonym: "integrin alpha with I domain" EXACT []
xref: PIRSF:PIRSF002497
is_a: PR:000025796 ! integrin alpha

[Term]
id: PR:000001012
name: integrin alpha-M
namespace: protein
def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [UniProtKB:P11215]
comment: Category=gene. Requested by=CL.
synonym: "CD11 antigen-like family member B" EXACT []
synonym: "CD11B" RELATED Gene-based []
synonym: "CD11b" EXACT []
synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT []
synonym: "CR-3 alpha chain" EXACT []
synonym: "CR3A" RELATED Gene-based []
synonym: "ITGAM" EXACT PRO-short-label [PRO:DNx]
synonym: "leukocyte adhesion receptor MO1" EXACT []
synonym: "neutrophil adherence receptor" EXACT []
xref: IUPHARobj:2452
is_a: PR:000001005 ! integrin alpha with A domain
property_value: vocab:crossSpeciesExactMatch PR:P11215

[Term]
id: PR:000001018
name: CD3 subunit with immunoglobulin domain
namespace: protein
def: "A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response." [PMID:16473826, PMID:1724736]
comment: Category=family.
synonym: "CD3 subunit with Ig-like domain" EXACT []
xref: PIRSF:PIRSF001993
is_a: PR:000000001 ! protein

[Term]
id: PR:000001020
name: CD3 epsilon
namespace: protein
def: "A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "CD3E" EXACT PRO-short-label [PRO:DNx]
synonym: "CD3e" EXACT []
synonym: "T-cell surface antigen T3/Leu-4 epsilon chain" EXACT []
synonym: "T3E" RELATED Gene-based []
xref: IUPHARobj:2742
is_a: PR:000001018 ! CD3 subunit with immunoglobulin domain

[Term]
id: PR:000001022
name: neural cell adhesion molecule
namespace: protein
def: "A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain." [PRO:CNA]
comment: Category=family.
xref: PIRSF:PIRSF002507
is_a: PR:000000001 ! protein

[Term]
id: PR:000001023
name: neural cell adhesion molecule NCAM
namespace: protein
def: "A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration." [PMID:17975827]
comment: Category=family.
xref: PIRSF:PIRSF501037
is_a: PR:000001022 ! neural cell adhesion molecule

[Term]
id: PR:000001024
name: neural cell adhesion molecule 1
namespace: protein
def: "A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "CD56" EXACT []
synonym: "N-CAM-1" EXACT []
synonym: "NCAM" RELATED Gene-based []
synonym: "NCAM-1" EXACT []
synonym: "NCAM1" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2769
is_a: PR:000001023 ! neural cell adhesion molecule NCAM
property_value: vocab:crossSpeciesExactMatch PR:P13591

[Term]
id: PR:000001083
name: CD2 molecule
namespace: protein
def: "A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "CD2" EXACT PRO-short-label [PRO:DNx]
synonym: "erythrocyte receptor" EXACT []
synonym: "LFA-2" EXACT []
synonym: "LFA-3 receptor" EXACT []
synonym: "ly-37" EXACT []
synonym: "lymphocyte antigen 37" EXACT []
synonym: "rosette receptor" EXACT []
synonym: "SRBC" RELATED Gene-based []
synonym: "T-cell surface antigen CD2" EXACT []
synonym: "T-cell surface antigen T11/Leu-5" EXACT []
synonym: "T-cell surface glycoprotein CD2" EXACT []
xref: IUPHARobj:2600
xref: PIRSF:PIRSF001984
is_a: PR:000000001 ! protein

[Term]
id: PR:000001084
name: T-cell surface glycoprotein CD8 alpha chain
namespace: protein
def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8]
comment: Category=gene. Requested by=CL.
synonym: "CD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a" EXACT []
synonym: "Lyt-2" RELATED Gene-based []
synonym: "Lyt2" RELATED Gene-based []
synonym: "MAL" RELATED Gene-based []
synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P01732

[Term]
id: PR:000001289
name: membrane-spanning 4-domains subfamily A member 1
namespace: protein
def: "A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "B-cell differentiation antigen Ly-44" EXACT []
synonym: "B-cell surface antigen CD20" EXACT []
synonym: "B-lymphocyte antigen CD20" EXACT []
synonym: "B-lymphocyte surface antigen B1" EXACT []
synonym: "Bp35" EXACT []
synonym: "CD20" RELATED Gene-based []
synonym: "leukocyte surface antigen Leu-16" EXACT []
synonym: "Ly-44" RELATED Gene-based []
synonym: "lymphocyte antigen 44" EXACT []
synonym: "MS4A1" EXACT PRO-short-label [PRO:DNx]
synonym: "Ms4a2" RELATED Gene-based []
xref: IUPHARobj:2628
xref: PIRSF:PIRSF001995
is_a: PR:000000001 ! protein

[Term]
id: PR:000001327
name: cadherin
namespace: protein
def: "A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues." [PRO:WCB]
comment: Category=family.
xref: PIRSF:PIRSF002504
is_a: PR:000000001 ! protein

[Term]
id: PR:000001444
name: cadherin-5
namespace: protein
def: "A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "7B4 antigen" EXACT []
synonym: "CD144" EXACT []
synonym: "CDH5" EXACT PRO-short-label [PRO:DNx]
synonym: "vascular endothelial cadherin" EXACT []
synonym: "VE-cadherin" EXACT []
is_a: PR:000001327 ! cadherin
property_value: vocab:crossSpeciesExactMatch PR:P33151

[Term]
id: PR:000001839
name: T-cell surface glycoprotein CD5
namespace: protein
def: "A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CD5" EXACT PRO-short-label [PRO:DNx]
synonym: "LEU1" RELATED Gene-based []
synonym: "ly-1" EXACT []
synonym: "lymphocyte antigen 1" EXACT []
synonym: "lymphocyte antigen T1/Leu-1" EXACT []
synonym: "Lyt-1" EXACT []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P06127

[Term]
id: PR:000001869
name: interleukin-7 receptor subunit alpha
namespace: protein
def: "A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CD127" EXACT []
synonym: "CDw127" EXACT []
synonym: "IL-7 receptor subunit alpha" EXACT []
synonym: "IL-7R subunit alpha" EXACT []
synonym: "IL-7R-alpha" EXACT []
synonym: "IL-7RA" EXACT []
synonym: "IL7R" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1698
xref: PIRSF:PIRSF001960
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P16871

[Term]
id: PR:000001889
name: CD14 molecule
namespace: protein
def: "A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CD14" EXACT PRO-short-label [PRO:DNx]
synonym: "monocyte differentiation antigen CD14" EXACT []
synonym: "myeloid cell-specific leucine-rich glycoprotein" EXACT []
xref: PIRSF:PIRSF002017
is_a: PR:000000001 ! protein

[Term]
id: PR:000001945
name: transferrin receptor protein 1
namespace: protein
def: "A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CD71" EXACT []
synonym: "p90" BROAD [PRO:DNx]
synonym: "T9" EXACT []
synonym: "TfR" EXACT []
synonym: "TfR1" EXACT []
synonym: "TFRC" EXACT PRO-short-label [PRO:DNx]
synonym: "TR" RELATED []
synonym: "Trfr" RELATED Gene-based []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P02786

[Term]
id: PR:000001971
name: vascular endothelial growth factor receptor
namespace: protein
def: "A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain." [PRO:WCB]
comment: Category=family.
xref: PIRSF:PIRSF038502
is_a: PR:000000001 ! protein

[Term]
id: PR:000002112
name: vascular endothelial growth factor receptor 2
namespace: protein
def: "A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "CD309" EXACT []
synonym: "fetal liver kinase 1" EXACT []
synonym: "FLK-1" EXACT []
synonym: "FLK1" RELATED Gene-based []
synonym: "KDR" EXACT PRO-short-label [PRO:DNx]
synonym: "kinase insert domain receptor" EXACT []
synonym: "kinase NYK" EXACT []
synonym: "protein-tyrosine kinase receptor flk-1" EXACT []
synonym: "VEGFR-2" EXACT []
synonym: "VEGFR2" RELATED Gene-based []
xref: IUPHARobj:1813
is_a: PR:000001971 ! vascular endothelial growth factor receptor
property_value: vocab:crossSpeciesExactMatch PR:P35968

[Term]
id: PR:000002976
name: Ly-6-like protein
namespace: protein
def: "A protein that is the translation product of any of the LY6 genes (LY6A-LY6I)." [PRO:CNA]
comment: Category=family.
xref: PIRSF:PIRSF002021
is_a: PR:000000001 ! protein

[Term]
id: PR:000002978
name: lymphocyte antigen 6G
namespace: protein
def: "An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene. Requested by=CL.
synonym: "Ly-6G" EXACT []
synonym: "Ly-6G.1" EXACT []
synonym: "Ly6g" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002976 ! Ly-6-like protein

[Term]
id: PR:000002981
name: lymphocyte antigen 76 (mouse)
namespace: protein
def: "A protein that is a translation product of the Ly76 gene in mouse." [PMID:10848813, PRO:DAN]
comment: Category=organism-gene. Requested by=CL.
synonym: "mLy76" EXACT PRO-short-label [PRO:DNx]
synonym: "ter-119" EXACT []
synonym: "ter119" EXACT []
is_a: PR:000029032 ! Mus musculus protein

[Term]
id: PR:000007499
name: fibroblast growth factor 8
namespace: protein
def: "A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AIGF" RELATED Gene-based []
synonym: "androgen-induced growth factor" EXACT []
synonym: "FGF-8" EXACT []
synonym: "FGF8" EXACT PRO-short-label [PRO:DNx]
synonym: "HBGF-8" RELATED []
synonym: "heparin-binding growth factor 8" RELATED []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P55075

[Term]
id: PR:000009054
name: insulin gene translation product
namespace: protein
def: "An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "INS" EXACT PRO-short-label [PRO:DNx]
synonym: "insulin" BROAD [PRO:DAN]
is_a: PR:000045358 ! insulin family protein
property_value: vocab:crossSpeciesExactMatch PR:P01308

[Term]
id: PR:000014841
name: sonic hedgehog protein
namespace: protein
def: "A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "HHG-1" EXACT []
synonym: "Hhg1" RELATED Gene-based []
synonym: "SHH" EXACT PRO-short-label [PRO:DNx]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains" EXACT []
synonym: "ShhNC" EXACT []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:Q15465

[Term]
id: PR:000016043
name: T-cell acute lymphocytic leukemia protein 1
namespace: protein
def: "A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene. Requested by=CL.
synonym: "BHLHA17" RELATED Gene-based []
synonym: "bHLHa17" EXACT []
synonym: "class A basic helix-loop-helix protein 17" EXACT []
synonym: "SCL" RELATED Gene-based []
synonym: "stem cell protein" EXACT []
synonym: "T-cell leukemia/lymphoma protein 5" EXACT []
synonym: "TAL-1" EXACT []
synonym: "TAL1" EXACT PRO-short-label [PRO:DNx]
synonym: "TCL5" RELATED Gene-based []
is_a: PR:000000001 ! protein
property_value: vocab:crossSpeciesExactMatch PR:P17542

[Term]
id: PR:000018263
name: amino acid chain
namespace: protein
def: "An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds." [PRO:DAN, PRO:JSG]
comment: Category=polymer.
synonym: "peptide" NARROW [PRO:DAN]
synonym: "polypeptide" NARROW [PRO:DAN]
is_a: CHEBI:50047 ! organic amino compound
relationship: has_constituent_monomer CHEBI:33708 {minCardinality="2"} ! amino-acid residue

[Term]
id: PR:000025796
name: integrin alpha
namespace: protein
def: "A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif." [PMID:19693543]
comment: Category=family. Integrins are heterodimeric complexes of an alpha and a beta subunit. They are a structurally elaborate family of adhesion molecules that transmit signals bidirectionally across the plasma membrane by undergoing large-scale structural rearrangements. By regulating cell-cell and cell-matrix contacts, integrins participate in a wide-range of biological interactions including development, tissue repair, angiogenesis, inflammation and hemostasis. [PMID:10402956, PMID:11988479, PMID:9676575].
is_a: PR:000000001 ! protein

[Term]
id: PR:000029032
name: Mus musculus protein
namespace: protein
def: "A protein that is encoded in the genome of Mus musculus." [PRO:DAN]
synonym: "mouse protein" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000036194 ! eukaryotic protein
intersection_of: PR:000000001 ! protein
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000029060
name: Drosophila melanogaster protein
namespace: protein
def: "A protein that is encoded in the genome of Drosophila melanogaster." [PRO:DAN]
synonym: "fruit fly protein" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000036194 ! eukaryotic protein
intersection_of: PR:000000001 ! protein
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000029067
name: Homo sapiens protein
namespace: protein
def: "A protein that is encoded in the genome of Homo sapiens." [PRO:DAN]
synonym: "human protein" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000036194 ! eukaryotic protein
intersection_of: PR:000000001 ! protein
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036194
name: eukaryotic protein
namespace: protein
def: "A protein that is encoded in the genome of some Eukaryota." [PRO:DAN]
synonym: "Eukaryota protein" EXACT [PRO:DAN]
is_a: PR:000000001 ! protein
intersection_of: PR:000000001 ! protein
intersection_of: only_in_taxon NCBITaxon:2759 ! Eukaryota
relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota

[Term]
id: PR:000045358
name: insulin family protein
namespace: protein
def: "A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide." [PRO:DAN]
comment: Category=family.
synonym: "fam:INS" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000000001 ! protein

[Term]
id: PR:000050567
name: protein-containing material entity
namespace: protein
def: "A material entity that minimally consists of a protein." [PRO:DAN]
comment: Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566).
synonym: "protein" NARROW [PRO:DAN]
synonym: "protein aggregate" NARROW [PRO:DAN]
synonym: "protein complex" NARROW [PRO:DAN]
synonym: "protein-containing complex" NARROW [PRO:DAN]
is_a: BFO:0000040 ! material entity
intersection_of: BFO:0000040 ! material entity
intersection_of: has_part PR:000000001 ! protein
relationship: has_part PR:000000001 ! protein

[Term]
id: PR:P01308
name: insulin gene translation product (human)
namespace: protein
def: "An insulin gene translation product that is encoded in the genome of human." [PRO:DAN, UniProtKB:P01308]
comment: Category=organism-gene.
synonym: "hINS" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01308
is_a: PR:000009054 ! insulin gene translation product
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000009054 ! insulin gene translation product
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01730
name: T-cell surface glycoprotein CD4 (human)
namespace: protein
def: "A CD4 molecule that is encoded in the genome of human." [PRO:DNx, UniProtKB:P01730]
comment: Category=organism-gene.
synonym: "CD4" RELATED Gene-based [UniProtKB:P01730]
synonym: "hCD4" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface antigen T4/Leu-3 (human)" EXACT [UniProtKB:P01730]
xref: UniProtKB:P01730
is_a: PR:000001004 ! CD4 molecule
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001004 ! CD4 molecule
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01731
name: T-cell surface glycoprotein CD8 alpha chain (mouse)
namespace: protein
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse." [OMA:P01731, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd8a" RELATED Gene-based [UniProtKB:P01731]
synonym: "CD8a (mouse)" EXACT [UniProtKB:P01731]
synonym: "Lyt-2" RELATED Gene-based [UniProtKB:P01731]
synonym: "Lyt2" RELATED Gene-based [UniProtKB:P01731]
synonym: "mCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface glycoprotein Lyt-2 (mouse)" EXACT [UniProtKB:P01731]
xref: UniProtKB:P01731
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P01732
name: T-cell surface glycoprotein CD8 alpha chain (human)
namespace: protein
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732]
comment: Category=organism-gene.
synonym: "CD8A" RELATED Gene-based [UniProtKB:P01732]
synonym: "CD8a (human)" EXACT [UniProtKB:P01732]
synonym: "hCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "MAL" RELATED Gene-based [UniProtKB:P01732]
synonym: "T-lymphocyte differentiation antigen T8/Leu-2 (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P02786
name: transferrin receptor protein 1 (human)
namespace: protein
def: "A transferrin receptor protein 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P02786]
comment: Category=organism-gene.
synonym: "CD71 (human)" EXACT [UniProtKB:P02786]
synonym: "hTFRC" EXACT PRO-short-label [PRO:DNx]
synonym: "p90 (human)" BROAD [UniProtKB:P02786]
synonym: "T9 (human)" EXACT [UniProtKB:P02786]
synonym: "TfR (human)" EXACT [UniProtKB:P02786]
synonym: "TfR1 (human)" EXACT [UniProtKB:P02786]
synonym: "TFRC" RELATED Gene-based [UniProtKB:P02786]
synonym: "TR (human)" BROAD [UniProtKB:P02786]
synonym: "Trfr (human)" EXACT [UniProtKB:P02786]
xref: Reactome:R-HSA-434196 "PR:P02786 located_in GO:0030659"
xref: Reactome:R-HSA-434330 "PR:P02786 located_in GO:0000139"
xref: Reactome:R-HSA-8869124 "PR:P02786 located_in GO:0030665"
xref: Reactome:R-HSA-8961829 "PR:P02786 located_in GO:0010008"
xref: Reactome:R-HSA-917983 "PR:P02786 located_in GO:0005886"
xref: UniProtKB:P02786
is_a: PR:000001945 ! transferrin receptor protein 1
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001945 ! transferrin receptor protein 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05555
name: integrin alpha-M (mouse)
namespace: protein
def: "An integrin alpha-M that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P05555]
comment: Category=organism-gene.
synonym: "CD11 antigen-like family member B (mouse)" EXACT [UniProtKB:P05555]
synonym: "CD11b (mouse)" EXACT [UniProtKB:P05555]
synonym: "cell surface glycoprotein MAC-1 subunit alpha (mouse)" EXACT [UniProtKB:P05555]
synonym: "CR-3 alpha chain (mouse)" EXACT [UniProtKB:P05555]
synonym: "Itgam" RELATED Gene-based [UniProtKB:P05555]
synonym: "leukocyte adhesion receptor MO1 (mouse)" EXACT [UniProtKB:P05555]
synonym: "mITGAM" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05555
is_a: PR:000001012 ! integrin alpha-M
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001012 ! integrin alpha-M
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P06127
name: T-cell surface glycoprotein CD5 (human)
namespace: protein
def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P06127]
comment: Category=organism-gene.
synonym: "CD5" RELATED Gene-based [UniProtKB:P06127]
synonym: "hCD5" EXACT PRO-short-label [PRO:DNx]
synonym: "LEU1" RELATED Gene-based [UniProtKB:P06127]
synonym: "lymphocyte antigen T1/Leu-1 (human)" EXACT [UniProtKB:P06127]
xref: UniProtKB:P06127
is_a: PR:000001839 ! T-cell surface glycoprotein CD5
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06332
name: T-cell surface glycoprotein CD4 (mouse)
namespace: protein
def: "A CD4 molecule that is encoded in the genome of mouse." [OMA:P06332, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd4" RELATED Gene-based [UniProtKB:P06332]
synonym: "CD4 (mouse)" EXACT [UniProtKB:P06332]
synonym: "mCD4" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell differentiation antigen L3T4 (mouse)" EXACT [UniProtKB:P06332]
synonym: "T-cell surface antigen T4/Leu-3 (mouse)" EXACT [UniProtKB:P06332]
xref: UniProtKB:P06332
is_a: PR:000001004 ! CD4 molecule
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001004 ! CD4 molecule
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P06729
name: T-cell surface antigen CD2 (human)
namespace: protein
def: "A CD2 molecule that is encoded in the genome of human." [PRO:CNA, UniProtKB:P06729]
comment: Category=organism-gene.
synonym: "CD2" RELATED Gene-based [UniProtKB:P06729]
synonym: "erythrocyte receptor (human)" EXACT [UniProtKB:P06729]
synonym: "hCD2" EXACT PRO-short-label [PRO:DNx]
synonym: "LFA-2 (human)" EXACT [UniProtKB:P06729]
synonym: "LFA-3 receptor (human)" EXACT [UniProtKB:P06729]
synonym: "rosette receptor (human)" EXACT [UniProtKB:P06729]
synonym: "SRBC" RELATED Gene-based [UniProtKB:P06729]
synonym: "T-cell surface antigen T11/Leu-5 (human)" EXACT [UniProtKB:P06729]
xref: UniProtKB:P06729
is_a: PR:000001083 ! CD2 molecule
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001083 ! CD2 molecule
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P07766
name: T-cell surface glycoprotein CD3 epsilon chain (human)
namespace: protein
def: "A CD3 epsilon that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07766]
comment: Category=organism-gene.
synonym: "CD3E" RELATED Gene-based [UniProtKB:P07766]
synonym: "CD3e (human)" EXACT [UniProtKB:P07766]
synonym: "hCD3E" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (human)" EXACT [UniProtKB:P07766]
synonym: "T3E" RELATED Gene-based [UniProtKB:P07766]
xref: UniProtKB:P07766
is_a: PR:000001020 ! CD3 epsilon
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001020 ! CD3 epsilon
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08571
name: monocyte differentiation antigen CD14 (human)
namespace: protein
def: "A CD14 molecule that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08571]
comment: Category=organism-gene.
synonym: "CD14" RELATED Gene-based [UniProtKB:P08571]
synonym: "hCD14" EXACT PRO-short-label [PRO:DNx]
synonym: "myeloid cell-specific leucine-rich glycoprotein (human)" EXACT [UniProtKB:P08571]
xref: UniProtKB:P08571
is_a: PR:000001889 ! CD14 molecule
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001889 ! CD14 molecule
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08920
name: T-cell surface antigen CD2 (mouse)
namespace: protein
def: "A CD2 molecule that is encoded in the genome of mouse." [OMA:P08920, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd2" RELATED Gene-based [UniProtKB:P08920]
synonym: "CD2 (mouse)" EXACT [UniProtKB:P08920]
synonym: "LFA-2 (mouse)" EXACT [UniProtKB:P08920]
synonym: "LFA-3 receptor (mouse)" EXACT [UniProtKB:P08920]
synonym: "Ly-37" RELATED Gene-based [UniProtKB:P08920]
synonym: "lymphocyte antigen 37 (mouse)" EXACT [UniProtKB:P08920]
synonym: "mCD2" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface antigen T11/Leu-5 (mouse)" EXACT [UniProtKB:P08920]
xref: UniProtKB:P08920
is_a: PR:000001083 ! CD2 molecule
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001083 ! CD2 molecule
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P10810
name: monocyte differentiation antigen CD14 (mouse)
namespace: protein
def: "A CD14 molecule that is encoded in the genome of mouse." [OMA:P10810, PRO:WCB]
comment: Category=organism-gene.
synonym: "Cd14" RELATED Gene-based [UniProtKB:P10810]
synonym: "CD14 (mouse)" EXACT [UniProtKB:P10810]
synonym: "mCD14" EXACT PRO-short-label [PRO:DNx]
synonym: "myeloid cell-specific leucine-rich glycoprotein (mouse)" EXACT [UniProtKB:P10810]
xref: UniProtKB:P10810
is_a: PR:000001889 ! CD14 molecule
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001889 ! CD14 molecule
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P11215
name: integrin alpha-M (human)
namespace: protein
def: "An integrin alpha-M that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11215]
comment: Category=organism-gene.
synonym: "CD11 antigen-like family member B (human)" EXACT [UniProtKB:P11215]
synonym: "CD11B" RELATED Gene-based [UniProtKB:P11215]
synonym: "cell surface glycoprotein MAC-1 subunit alpha (human)" EXACT [UniProtKB:P11215]
synonym: "CR-3 alpha chain (human)" EXACT [UniProtKB:P11215]
synonym: "CR3A" RELATED Gene-based [UniProtKB:P11215]
synonym: "hITGAM" EXACT PRO-short-label [PRO:DNx]
synonym: "ITGAM" RELATED Gene-based [UniProtKB:P11215]
synonym: "leukocyte adhesion receptor MO1 (human)" EXACT [UniProtKB:P11215]
synonym: "neutrophil adherence receptor (human)" EXACT [UniProtKB:P11215]
xref: UniProtKB:P11215
is_a: PR:000001012 ! integrin alpha-M
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001012 ! integrin alpha-M
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11836
name: B-lymphocyte antigen CD20 (human)
namespace: protein
def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P11836]
comment: Category=organism-gene.
synonym: "B-lymphocyte surface antigen B1 (human)" EXACT [UniProtKB:P11836]
synonym: "Bp35 (human)" EXACT [UniProtKB:P11836]
synonym: "CD20" RELATED Gene-based [UniProtKB:P11836]
synonym: "hMS4A1" EXACT PRO-short-label [PRO:DNx]
synonym: "leukocyte surface antigen Leu-16 (human)" EXACT [UniProtKB:P11836]
synonym: "membrane-spanning 4-domains subfamily A member 1 (human)" EXACT [UniProtKB:P11836]
synonym: "MS4A1" RELATED Gene-based [UniProtKB:P11836]
xref: UniProtKB:P11836
is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P13379
name: T-cell surface glycoprotein CD5 (mouse)
namespace: protein
def: "A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse." [OMA:P13379, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd5" RELATED Gene-based [UniProtKB:P13379]
synonym: "CD5 (mouse)" EXACT [UniProtKB:P13379]
synonym: "Ly-1" RELATED Gene-based [UniProtKB:P13379]
synonym: "lymphocyte antigen 1 (mouse)" EXACT [UniProtKB:P13379]
synonym: "Lyt-1 (mouse)" EXACT [UniProtKB:P13379]
synonym: "mCD5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P13379
is_a: PR:000001839 ! T-cell surface glycoprotein CD5
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001839 ! T-cell surface glycoprotein CD5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P13591
name: neural cell adhesion molecule 1 (human)
namespace: protein
def: "A neural cell adhesion molecule 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P13591]
comment: Category=organism-gene.
synonym: "CD56 (human)" EXACT [UniProtKB:P13591]
synonym: "hNCAM1" EXACT PRO-short-label [PRO:DNx]
synonym: "N-CAM-1 (human)" EXACT [UniProtKB:P13591]
synonym: "NCAM" RELATED Gene-based [UniProtKB:P13591]
synonym: "NCAM-1 (human)" EXACT [UniProtKB:P13591]
synonym: "NCAM1" RELATED Gene-based [UniProtKB:P13591]
xref: UniProtKB:P13591
is_a: PR:000001024 ! neural cell adhesion molecule 1
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001024 ! neural cell adhesion molecule 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P13595
name: neural cell adhesion molecule 1 (mouse)
namespace: protein
def: "A neural cell adhesion molecule 1 that is encoded in the genome of mouse." [OMA:P13595, PRO:DNx]
comment: Category=organism-gene.
synonym: "CD56 (mouse)" EXACT [UniProtKB:P13595]
synonym: "mNCAM1" EXACT PRO-short-label [PRO:DNx]
synonym: "N-CAM-1 (mouse)" EXACT [UniProtKB:P13595]
synonym: "Ncam" RELATED Gene-based [UniProtKB:P13595]
synonym: "NCAM-1 (mouse)" EXACT [UniProtKB:P13595]
synonym: "Ncam1" RELATED Gene-based [UniProtKB:P13595]
xref: UniProtKB:P13595
is_a: PR:000001024 ! neural cell adhesion molecule 1
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001024 ! neural cell adhesion molecule 1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P15391
name: B-lymphocyte antigen CD19 (human)
namespace: protein
def: "A CD19 molecule that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "B-lymphocyte surface antigen B4 (human)" EXACT [UniProtKB:P15391]
synonym: "CD19" RELATED Gene-based [UniProtKB:P15391]
synonym: "differentiation antigen CD19 (human)" EXACT [UniProtKB:P15391]
synonym: "hCD19" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface antigen Leu-12 (human)" EXACT [UniProtKB:P15391]
xref: UniProtKB:P15391
is_a: PR:000001002 ! CD19 molecule
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001002 ! CD19 molecule
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P16871
name: interleukin-7 receptor subunit alpha (human)
namespace: protein
def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16871]
comment: Category=organism-gene.
synonym: "CD127 (human)" EXACT [UniProtKB:P16871]
synonym: "CDw127 (human)" EXACT [UniProtKB:P16871]
synonym: "hIL7R" EXACT PRO-short-label [PRO:DNx]
synonym: "IL-7 receptor subunit alpha (human)" EXACT [UniProtKB:P16871]
synonym: "IL-7R subunit alpha (human)" EXACT [UniProtKB:P16871]
synonym: "IL-7R-alpha (human)" EXACT [UniProtKB:P16871]
synonym: "IL-7RA (human)" EXACT [UniProtKB:P16871]
synonym: "IL7R" RELATED Gene-based [UniProtKB:P16871]
xref: UniProtKB:P16871
is_a: PR:000001869 ! interleukin-7 receptor subunit alpha
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P16872
name: interleukin-7 receptor subunit alpha (mouse)
namespace: protein
def: "An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse." [OMA:P16872, PRO:DNx]
comment: Category=organism-gene.
synonym: "CD127 (mouse)" EXACT [UniProtKB:P16872]
synonym: "IL-7 receptor subunit alpha (mouse)" EXACT [UniProtKB:P16872]
synonym: "IL-7R subunit alpha (mouse)" EXACT [UniProtKB:P16872]
synonym: "IL-7R-alpha (mouse)" EXACT [UniProtKB:P16872]
synonym: "IL-7RA (mouse)" EXACT [UniProtKB:P16872]
synonym: "Il7r" RELATED Gene-based [UniProtKB:P16872]
synonym: "mIL7R" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P16872
is_a: PR:000001869 ! interleukin-7 receptor subunit alpha
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001869 ! interleukin-7 receptor subunit alpha
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P17542
name: T-cell acute lymphocytic leukemia protein 1 (human)
namespace: protein
def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P17542]
comment: Category=organism-gene.
synonym: "BHLHA17" RELATED Gene-based [UniProtKB:P17542]
synonym: "class A basic helix-loop-helix protein 17 (human)" EXACT [UniProtKB:P17542]
synonym: "hTAL1" EXACT PRO-short-label [PRO:DNx]
synonym: "SCL" RELATED Gene-based [UniProtKB:P17542]
synonym: "Stem cell protein (human)" EXACT [UniProtKB:P17542]
synonym: "T-cell leukemia/lymphoma protein 5 (human)" EXACT [UniProtKB:P17542]
synonym: "TAL-1 (human)" EXACT [UniProtKB:P17542]
synonym: "TAL1" RELATED Gene-based [UniProtKB:P17542]
synonym: "TCL5" RELATED Gene-based [UniProtKB:P17542]
xref: Reactome:R-HSA-8956511 "PR:P17542 located_in GO:0005654"
xref: UniProtKB:P17542
is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19437
name: B-lymphocyte antigen CD20 (mouse)
namespace: protein
def: "A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse." [OMA:P19437, PRO:DNx]
comment: Category=organism-gene.
synonym: "B-cell differentiation antigen Ly-44 (mouse)" EXACT [UniProtKB:P19437]
synonym: "Cd20" RELATED Gene-based [UniProtKB:P19437]
synonym: "CD20 (mouse)" EXACT [UniProtKB:P19437]
synonym: "Ly-44" RELATED Gene-based [UniProtKB:P19437]
synonym: "lymphocyte antigen 44 (mouse)" EXACT [UniProtKB:P19437]
synonym: "membrane-spanning 4-domains subfamily A member 1 (mouse)" EXACT [UniProtKB:P19437]
synonym: "mMS4A1" EXACT PRO-short-label [PRO:DNx]
synonym: "Ms4a1" RELATED Gene-based [UniProtKB:P19437]
synonym: "Ms4a2" RELATED Gene-based [UniProtKB:P19437]
xref: UniProtKB:P19437
is_a: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001289 ! membrane-spanning 4-domains subfamily A member 1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P22091
name: T-cell acute lymphocytic leukemia protein 1 homolog (mouse)
namespace: protein
def: "A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse." [OMA:P22091, PRO:DNx]
comment: Category=organism-gene.
synonym: "mTAL1" EXACT PRO-short-label [PRO:DNx]
synonym: "Scl" RELATED Gene-based [UniProtKB:P22091]
synonym: "Stem cell protein (mouse)" EXACT [UniProtKB:P22091]
synonym: "Tal-1" RELATED Gene-based [UniProtKB:P22091]
synonym: "TAL-1 (mouse)" EXACT [UniProtKB:P22091]
synonym: "Tal1" RELATED Gene-based [UniProtKB:P22091]
xref: UniProtKB:P22091
is_a: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000016043 ! T-cell acute lymphocytic leukemia protein 1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P22646
name: T-cell surface glycoprotein CD3 epsilon chain (mouse)
namespace: protein
def: "A CD3 epsilon that is encoded in the genome of mouse." [OMA:P22646, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd3e" RELATED Gene-based [UniProtKB:P22646]
synonym: "CD3e (mouse)" EXACT [UniProtKB:P22646]
synonym: "mCD3E" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface antigen T3/Leu-4 epsilon chain (mouse)" EXACT [UniProtKB:P22646]
xref: UniProtKB:P22646
is_a: PR:000001020 ! CD3 epsilon
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001020 ! CD3 epsilon
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P25918
name: B-lymphocyte antigen CD19 (mouse)
namespace: protein
def: "A CD19 molecule that is encoded in the genome of mouse." [OMA:P25918, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd19" RELATED Gene-based [UniProtKB:P25918]
synonym: "CD19 (mouse)" EXACT [UniProtKB:P25918]
synonym: "differentiation antigen CD19 (mouse)" EXACT [UniProtKB:P25918]
synonym: "mCD19" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25918
is_a: PR:000001002 ! CD19 molecule
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001002 ! CD19 molecule
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28906
name: hematopoietic progenitor cell antigen CD34 (human)
namespace: protein
def: "A CD34 molecule that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "CD34" RELATED Gene-based [UniProtKB:P28906]
synonym: "hCD34" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28906
is_a: PR:000001003 ! CD34 molecule
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001003 ! CD34 molecule
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P33151
name: cadherin-5 (human)
namespace: protein
def: "A cadherin-5 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P33151]
comment: Category=organism-gene.
synonym: "7B4 antigen (human)" EXACT [UniProtKB:P33151]
synonym: "CD144 (human)" EXACT [UniProtKB:P33151]
synonym: "CDH5" RELATED Gene-based [UniProtKB:P33151]
synonym: "hCDH5" EXACT PRO-short-label [PRO:DNx]
synonym: "vascular endothelial cadherin (human)" EXACT [UniProtKB:P33151]
synonym: "VE-cadherin (human)" EXACT [UniProtKB:P33151]
xref: UniProtKB:P33151
is_a: PR:000001444 ! cadherin-5
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000001444 ! cadherin-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P35461
name: lymphocyte antigen 6G (mouse)
namespace: protein
def: "A lymphocyte antigen 6G that is encoded in the genome of mouse." [PRO:CNA, UniProtKB:P35461]
comment: Category=organism-gene.
synonym: "Ly-6G (mouse)" EXACT [UniProtKB:P35461]
synonym: "Ly-6G.1 (mouse)" EXACT [UniProtKB:P35461]
synonym: "Ly6g" RELATED Gene-based [UniProtKB:P35461]
synonym: "mLy6g" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P35461
is_a: PR:000002978 ! lymphocyte antigen 6G
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000002978 ! lymphocyte antigen 6G
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P35918
name: vascular endothelial growth factor receptor 2 (mouse)
namespace: protein
def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse." [OMA:P35918, PRO:DNx]
comment: Category=organism-gene.
synonym: "CD309 (mouse)" EXACT [UniProtKB:P35918]
synonym: "fetal liver kinase 1 (mouse)" EXACT [UniProtKB:P35918]
synonym: "Flk-1" RELATED Gene-based [UniProtKB:P35918]
synonym: "FLK-1 (mouse)" EXACT [UniProtKB:P35918]
synonym: "Flk1" RELATED Gene-based [UniProtKB:P35918]
synonym: "Kdr" RELATED Gene-based [UniProtKB:P35918]
synonym: "kinase NYK (mouse)" EXACT [UniProtKB:P35918]
synonym: "mKDR" EXACT PRO-short-label [PRO:DNx]
synonym: "protein-tyrosine kinase receptor flk-1 (mouse)" EXACT [UniProtKB:P35918]
synonym: "VEGFR-2 (mouse)" EXACT [UniProtKB:P35918]
xref: UniProtKB:P35918
is_a: PR:000002112 ! vascular endothelial growth factor receptor 2
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P35968
name: vascular endothelial growth factor receptor 2 (human)
namespace: protein
def: "A vascular endothelial growth factor receptor 2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P35968]
comment: Category=organism-gene.
synonym: "CD309 (human)" EXACT [UniProtKB:P35968]
synonym: "fetal liver kinase 1 (human)" EXACT [UniProtKB:P35968]
synonym: "FLK-1 (human)" EXACT [UniProtKB:P35968]
synonym: "FLK1" RELATED Gene-based [UniProtKB:P35968]
synonym: "hKDR" EXACT PRO-short-label [PRO:DNx]
synonym: "KDR" RELATED Gene-based [UniProtKB:P35968]
synonym: "kinase insert domain receptor (human)" EXACT [UniProtKB:P35968]
synonym: "protein-tyrosine kinase receptor flk-1 (human)" EXACT [UniProtKB:P35968]
synonym: "VEGFR-2 (human)" EXACT [UniProtKB:P35968]
synonym: "VEGFR2" RELATED Gene-based [UniProtKB:P35968]
xref: DTO:03100560
xref: UniProtKB:P35968
is_a: PR:000002112 ! vascular endothelial growth factor receptor 2
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000002112 ! vascular endothelial growth factor receptor 2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37237
name: fibroblast growth factor 8 (mouse)
namespace: protein
def: "A fibroblast growth factor 8 that is encoded in the genome of mouse." [OMA:P37237, PRO:DNx]
comment: Category=organism-gene.
synonym: "Aigf" RELATED Gene-based [UniProtKB:P37237]
synonym: "AIGF (mouse)" EXACT [UniProtKB:P37237]
synonym: "androgen-induced growth factor (mouse)" EXACT [UniProtKB:P37237]
synonym: "FGF-8 (mouse)" EXACT [UniProtKB:P37237]
synonym: "Fgf8" RELATED Gene-based [UniProtKB:P37237]
synonym: "HBGF-8 (mouse)" RELATED [UniProtKB:P37237]
synonym: "heparin-binding growth factor 8 (mouse)" RELATED [UniProtKB:P37237]
synonym: "mFGF8" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P37237
is_a: PR:000007499 ! fibroblast growth factor 8
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000007499 ! fibroblast growth factor 8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P55075
name: fibroblast growth factor 8 (human)
namespace: protein
def: "A fibroblast growth factor 8 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55075]
comment: Category=organism-gene.
synonym: "AIGF" RELATED Gene-based [UniProtKB:P55075]
synonym: "androgen-induced growth factor (human)" EXACT [UniProtKB:P55075]
synonym: "FGF-8 (human)" EXACT [UniProtKB:P55075]
synonym: "FGF8" RELATED Gene-based [UniProtKB:P55075]
synonym: "HBGF-8 (human)" BROAD [UniProtKB:P55075]
synonym: "heparin-binding growth factor 8 (human)" BROAD [UniProtKB:P55075]
synonym: "hFGF8" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55075
is_a: PR:000007499 ! fibroblast growth factor 8
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000007499 ! fibroblast growth factor 8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P55284
name: cadherin-5 (mouse)
namespace: protein
def: "A cadherin-5 that is encoded in the genome of mouse." [OMA:P55284, PRO:DNx]
comment: Category=organism-gene.
synonym: "CD144 (mouse)" EXACT [UniProtKB:P55284]
synonym: "Cdh5" RELATED Gene-based [UniProtKB:P55284]
synonym: "mCDH5" EXACT PRO-short-label [PRO:DNx]
synonym: "vascular endothelial cadherin (mouse)" EXACT [UniProtKB:P55284]
synonym: "VE-cadherin (mouse)" EXACT [UniProtKB:P55284]
xref: UniProtKB:P55284
is_a: PR:000001444 ! cadherin-5
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001444 ! cadherin-5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q15465
name: sonic hedgehog protein (human)
namespace: protein
def: "A sonic hedgehog protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15465]
comment: Category=organism-gene.
synonym: "HHG-1 (human)" EXACT [UniProtKB:Q15465]
synonym: "hSHH" EXACT PRO-short-label [PRO:DNx]
synonym: "SHH" RELATED Gene-based [UniProtKB:Q15465]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (human)" EXACT [UniProtKB:Q15465]
synonym: "ShhNC (human)" EXACT [UniProtKB:Q15465]
xref: UniProtKB:Q15465
is_a: PR:000014841 ! sonic hedgehog protein
is_a: PR:000029067 ! Homo sapiens protein
intersection_of: PR:000014841 ! sonic hedgehog protein
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q62226
name: sonic hedgehog protein (mouse)
namespace: protein
def: "A sonic hedgehog protein that is encoded in the genome of mouse." [OMA:Q62226, PRO:DNx]
comment: Category=organism-gene.
synonym: "HHG-1 (mouse)" EXACT [UniProtKB:Q62226]
synonym: "Hhg1" RELATED Gene-based [UniProtKB:Q62226]
synonym: "mSHH" EXACT PRO-short-label [PRO:DNx]
synonym: "Shh" RELATED Gene-based [UniProtKB:Q62226]
synonym: "SHH (mouse)" EXACT [UniProtKB:Q62226]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)" EXACT [UniProtKB:Q62226]
synonym: "ShhNC (mouse)" EXACT [UniProtKB:Q62226]
xref: UniProtKB:Q62226
is_a: PR:000014841 ! sonic hedgehog protein
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000014841 ! sonic hedgehog protein
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q62351
name: transferrin receptor protein 1 (mouse)
namespace: protein
def: "A transferrin receptor protein 1 that is encoded in the genome of mouse." [OMA:Q62351, PRO:DNx]
comment: Category=organism-gene.
synonym: "CD71 (mouse)" EXACT [UniProtKB:Q62351]
synonym: "mTFRC" EXACT PRO-short-label [PRO:DNx]
synonym: "TfR (mouse)" EXACT [UniProtKB:Q62351]
synonym: "TfR1 (mouse)" EXACT [UniProtKB:Q62351]
synonym: "Tfrc" RELATED Gene-based [UniProtKB:Q62351]
synonym: "TR (mouse)" RELATED [UniProtKB:Q62351]
synonym: "Trfr" RELATED Gene-based [UniProtKB:Q62351]
xref: UniProtKB:Q62351
is_a: PR:000001945 ! transferrin receptor protein 1
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001945 ! transferrin receptor protein 1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q64314
name: hematopoietic progenitor cell antigen CD34 (mouse)
namespace: protein
def: "A CD34 molecule that is encoded in the genome of mouse." [OMA:Q64314, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd34" RELATED Gene-based [UniProtKB:Q64314]
synonym: "CD34 (mouse)" EXACT [UniProtKB:Q64314]
synonym: "mCD34" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64314
is_a: PR:000001003 ! CD34 molecule
is_a: PR:000029032 ! Mus musculus protein
intersection_of: PR:000001003 ! CD34 molecule
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q9V7U0
name: pro-resilin (fruit fly)
namespace: protein
def: "A protein that is a translation product of the resilin gene in fruit fly." [PRO:DNx, UniProtKB:Q9V7U0]
comment: Category=organism-gene.
synonym: "CG15920" RELATED Gene-based [UniProtKB:Q9V7U0]
synonym: "fly-resilin" EXACT PRO-short-label [PRO:DNx]
synonym: "resilin" RELATED Gene-based [UniProtKB:Q9V7U0]
xref: UniProtKB:Q9V7U0
is_a: PR:000029060 ! Drosophila melanogaster protein
intersection_of: PR:000000001 ! protein
intersection_of: has_gene_template http://flybase.org/reports/FBgn0034157 ! resilin (fruit fly)
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
relationship: has_gene_template http://flybase.org/reports/FBgn0034157 ! resilin (fruit fly)

[Term]
id: RO:0002577
name: system
def: "A material entity consisting of multiple components that are causally integrated." []
is_a: BFO:0000040 ! material entity
property_value: editor_note "May be replaced by a BFO class, as discussed in http://www.jbiomedsem.com/content/4/1/43" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "http://www.jbiomedsem.com/content/4/1/43" xsd:string

[Term]
id: SO:0000010
name: protein_coding
namespace: sequence
comment: Category=external.
synonym: "protein-coding" EXACT []
is_a: BFO:0000019 ! quality

[Term]
id: SO:0000110
name: sequence_feature
namespace: sequence
def: "An extent of biological sequence." [SO:ke]
synonym: "located sequence feature" RELATED []
synonym: "located_sequence_feature" EXACT []
synonym: "sequence feature" EXACT []

[Term]
id: SO:0000704
name: gene
namespace: sequence
def: "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions." [SO:immuno_workshop]
is_a: SO:0000110 ! sequence_feature

[Term]
id: SO:0001217
name: protein_coding_gene
namespace: sequence
synonym: "protein coding gene" EXACT []
is_a: SO:0000704 ! gene
relationship: has_quality SO:0000010 ! protein_coding

[Term]
id: UBERON:0000000
name: processual entity
namespace: uberon
def: "An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity." [span:ProcessualEntity]
subset: common_anatomy
subset: upper_level
xref: BFO:0000003
is_a: BFO:0000003 ! occurrent
disjoint_from: UBERON:0001062 ! anatomical entity
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000005
name: chemosensory organ
namespace: uberon
subset: functional_classification
subset: uberon_slim
synonym: "chemosensory sensory organ" EXACT [FBbt:00005157]
xref: FBbt:00005157 {sssom:mapping_justification="vocab:ManualMappingCuration"}
is_a: UBERON:0000020 ! sense organ
intersection_of: UBERON:0000020 ! sense organ
intersection_of: capable_of GO:0007606 ! sensory perception of chemical stimulus
relationship: capable_of GO:0007606 ! sensory perception of chemical stimulus
relationship: part_of UBERON:0001016 ! nervous system
relationship: part_of UBERON:0005726 ! chemosensory system

[Term]
id: UBERON:0000006
name: islet of Langerhans
namespace: uberon
def: "The clusters of hormone-producing cells that are scattered throughout the pancreas." [MA:0000127, MESH:A03.734.414, MP:0005215]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "island of Langerhans" RELATED [BTO:0000991]
synonym: "island of pancreas" RELATED [BTO:0000991]
synonym: "islets of Langerhans" RELATED []
synonym: "pancreatic insula" EXACT []
synonym: "pancreatic islet" EXACT []
xref: AAO:0010406
xref: BTO:0000991
xref: CALOHA:TS-0741
xref: EFO:0000856
xref: EMAPA:32927
xref: EV:0100130
xref: FMA:16016
xref: GAID:324
xref: MA:0000127
xref: MAT:0000076
xref: MESH:D007515
xref: MIAA:0000076
xref: NCIT:C12608
xref: UMLS:C0022131 {source="ncithesaurus:Islet_of_Langerhans"}
xref: VHOG:0000646
xref: Wikipedia:Islets_of_Langerhans
xref: XAO:0000159
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0034922 ! cell cluster
relationship: contributes_to_morphology_of UBERON:0000016 ! endocrine pancreas
relationship: has_part CL:0000168 {source="PMID:16417468"} ! insulin secreting cell
relationship: has_part CL:0000172 {source="PMID:16417468"} ! somatostatin secreting cell
relationship: has_part CL:0000696 {gci_filler="NCBITaxon:117570", gci_relation="part_of", source="PMID:16417468"} ! PP cell
relationship: has_part CL:0002067 {source="PMID:16417468"} ! type A enteroendocrine cell
relationship: part_of UBERON:0000016 ! endocrine pancreas
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Anatomical structure which consists of glands developed from pancreatic ducts in the larvae and secrete insulin.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010406", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Mammals, birds, reptiles and amphibians have a pancreas with similar histology and mode of development, while in some fish, the islet cells are segregated as Brockmann bodies.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000646", ontology="VHOG", source="PMID:7600975 Slack JMW, Developmental biology of the pancreas. Development (1995)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "A primitive exocrine pancreas can be found in holocephalan cartilaginous fish; a pancreatic duct directly ending in the gut lumen is connected to a glandular structure made of exocrine cells and associated with cell islets, which comprises three different hormone-producing cell types: insulin, somatostatin and glucagon (Yui and Fujita, 1986)" xsd:string {source="PMID:16417468"}
property_value: UBPROP:0000202 FMA:76489

[Term]
id: UBERON:0000009
name: submucosa
namespace: uberon
def: "A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]." [Wikipedia:Submucosa]
subset: pheno_slim
subset: uberon_slim
synonym: "organ submucosa" EXACT [FMA:85391]
synonym: "region of submucosa" EXACT [FMA:85392]
synonym: "submucosa of organ" EXACT [FMA:85391]
synonym: "submucosa of region of organ" EXACT [FMA:85392]
synonym: "submucous layer" RELATED [BTO:0002107]
synonym: "tela submucosa" RELATED [BTO:0002107]
synonym: "tunica submucosa" RELATED []
xref: BTO:0002107
xref: FMA:85391
xref: FMA:85392
xref: NCIT:C13167
xref: SCTID:68439008
xref: UMLS:C0225344 {source="ncithesaurus:Submucosa"}
xref: Wikipedia:Submucosa
is_a: UBERON:0004923 ! organ component layer
relationship: composed_primarily_of UBERON:0002384 ! connective tissue
relationship: immediately_deep_to UBERON:0000344 ! mucosa
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000007 "submucosal" xsd:string

[Term]
id: UBERON:0000010
name: peripheral nervous system
namespace: uberon
def: "A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GO:0007422]
subset: cumbo
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "pars peripherica" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system]
synonym: "PNS" BROAD OMO:0003000 []
synonym: "systema nervosum periphericum" EXACT OMO:0003011 [FMA:9903, FMA:TA, Wikipedia:Peripheral_nervous_system]
xref: AAO:0000429
xref: BAMS:PNS
xref: BILA:0000081
xref: BIRNLEX:1111
xref: BTO:0001028
xref: CALOHA:TS-0808
xref: EFO:0000891
xref: EHDAA2:0001445
xref: EHDAA:2893
xref: EMAPA:16665
xref: EV:0100335
xref: FBbt:00005098 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:9903
xref: GAID:715
xref: MA:0000218
xref: MAT:0000338
xref: MESH:D017933
xref: MIAA:0000338
xref: NCIT:C12465
xref: neuronames:3232
xref: SCTID:362292005
xref: TAO:0000142
xref: UMLS:C0206417 {source="ncithesaurus:Peripheral_Nervous_System", source="BIRNLEX:1111"}
xref: UMLS:C1305921 {source="BIRNLEX:1111"}
xref: VHOG:0000399
xref: Wikipedia:Peripheral_nervous_system
xref: XAO:0000178
xref: ZFA:0000142
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: part_of UBERON:0001016 ! nervous system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000142", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000429", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"}
property_value: UBPROP:0000003 "(...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000399", ontology="VHOG", source="DOI:10.1007/978-0-387-46954-6_6 Dupin E, Creuzet S, Le Douarin NM, The contribution of the neural crest to the vertebrate body. Advances in experimental medicine and biology (2006)", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000013
name: sympathetic nervous system
namespace: uberon
def: "The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]." [GO:0048485]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "pars sympathica divisionis autonomici systematis nervosi" EXACT OMO:0003011 [FMA:9906, FMA:TA]
synonym: "pars sympathica divisionis autonomici systematis nervosi" RELATED OMO:0003011 [Wikipedia:Sympathetic_nervous_system]
synonym: "sympathetic nervous system" EXACT []
synonym: "sympathetic part of autonomic division of nervous system" EXACT []
xref: AAO:0010487
xref: BIRNLEX:2516
xref: BTO:0001832
xref: CALOHA:TS-2050
xref: EFO:0000893
xref: EHDAA2:0001971
xref: EHDAA:3769
xref: EMAPA:16985
xref: FMA:9906
xref: GAID:710
xref: MA:0000225
xref: MESH:D013564
xref: MIAA:0000100
xref: NCIT:C12795
xref: SCTID:362484004
xref: TAO:0001576
xref: UMLS:C0039044 {source="BIRNLEX:2516", source="ncithesaurus:Sympathetic_Nervous_System"}
xref: UMLS:C1269646 {source="BIRNLEX:2516"}
xref: VHOG:0000384
xref: Wikipedia:Sympathetic_nervous_system
xref: ZFA:0001576
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system
relationship: part_of UBERON:0002410 {source="FMA", source="MA", source="ZFA-modified-from-isa"} ! autonomic nervous system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/7/77/Gray838.png" xsd:anyURI
property_value: UBPROP:0000001 "Part of the autonomic nervous system which has opposing physiological effects of the parasympathetic nervous system. Examples include increasing the heart rate or constricting the blood vessels.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010487", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The part of the autonomic nervous system which chiefly contains adrenergic fibres and tends to control and reduce secretions, decrease the contractility and hence the tone of smooth muscles and provoke the contraction of blood vessels. Essentially, it consists of preganglionic fibres from the thoracic and upper lumbar parts of the spinal cord. These fibres, by means of delicate rami communicantes, cross over to ganglia sited in a pair of ganglionated cords on each side of the vertebral column or to more peripheral ganglia. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The autonomic nervous system is composed of three divisions: the sympathetic division, the parasympathetic division, and the enteric division. (...) In ray-finned teleost fishes, a sympathetic chain is present, and dual innervation of additional organs can be observed. A similar pattern can be found in amphibians (...). The evolution of the autonomic nervous system has been quite conservative, especially in the tetrapod lineage.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000384", ontology="VHOG", source="ISBN:978-0471210054 Butler AB and Hodos W, Comparative vertebrate neuroanatomy: Evolution and Adaptation (2005) p.461-463", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "has developmental contribution from NC in verteberates (https://github.com/obophenotype/uberon/wiki/The-neural-crest)" xsd:string

[Term]
id: UBERON:0000014
name: zone of skin
namespace: uberon
def: "Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Skin]
subset: pheno_slim
synonym: "portion of skin" EXACT []
synonym: "region of skin" EXACT []
synonym: "skin" EXACT [MA:0000151]
synonym: "skin region" EXACT []
synonym: "skin zone" EXACT []
xref: EHDAA2:0001844
xref: EHDAA:6530
xref: EMAPA:17525
xref: EV:0100152
xref: FMA:86166
xref: GAID:933
xref: MA:0000151
xref: MAT:0000284
xref: MESH:D012867
xref: MIAA:0000284
xref: SCTID:20795001
xref: VHOG:0000860
xref: Wikipedia:Skin
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0034944 {source="FMA"} ! zone of organ
relationship: has_part UBERON:0001003 ! skin epidermis
relationship: has_part UBERON:0002067 ! dermis
relationship: part_of UBERON:0002097 ! skin of body
property_value: curator_notes "Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee" xsd:string
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg" xsd:anyURI
property_value: UBPROP:0000003 "(...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000860", ontology="VHOG", source="DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive" xsd:string

[Term]
id: UBERON:0000015
name: non-material anatomical boundary
namespace: uberon
def: "A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures." [CARO:0000010]
comment: Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms.
subset: common_anatomy
subset: upper_level
synonym: "anatomical boundary" EXACT [CARO:0000010]
xref: AEO:0000192
xref: CARO:0000010
xref: FMA:50705
is_a: UBERON:0000466 {source="CARO"} ! immaterial anatomical entity
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000016
name: endocrine pancreas
namespace: uberon
def: "The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin." [GO:GO, http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: human_reference_atlas
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "endocrine pancreas" EXACT []
synonym: "endocrine part of pancreas" RELATED [BTO:0000650]
synonym: "islets of Langerhans part of pancreas" RELATED []
synonym: "pars endocrina pancreatis" EXACT []
xref: BTO:0000650
xref: CALOHA:TS-1302
xref: EFO:0002542
xref: EMAPA:35305
xref: EV:0100129
xref: FMA:16018
xref: MA:0001582
xref: MESH:D007515 {sssom:mapping_provider="https://github.com/biopragmatics/biomappings", sssom:mapping_justification="vocab:LexicalMatching"}
xref: NCIT:C32509
xref: SCTID:361339003
xref: TAO:0001260
xref: VHOG:0000049
xref: Wikipedia:Islets_of_Langerhans
xref: ZFA:0001260
is_a: UBERON:0000471 {source="ZFA"} ! compound organ component
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: capable_of GO:0030073 {source="GO"} ! insulin secretion
relationship: capable_of GO:0070091 {source="GO"} ! glucagon secretion
relationship: capable_of GO:0070253 {source="GO"} ! somatostatin secretion
relationship: composed_primarily_of UBERON:0000006 ! islet of Langerhans
relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas
relationship: develops_from UBERON:0003923 ! dorsal pancreatic bud
relationship: part_of NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000949 {source="AAO", source="FMA", source="XAO"} ! endocrine system
relationship: part_of UBERON:0001264 ! pancreas
property_value: editor_note "create a separate class for distributed pancreas, eg cyclostomes?" xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"}
property_value: UBPROP:0000001 "The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001260", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000049", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "endocrine and exocrine pancreas are not co-associated in hagfishes or lampreys" xsd:string {source="PMID:20959416"}

[Term]
id: UBERON:0000017
name: exocrine pancreas
namespace: uberon
def: "The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]." [GOC:GO, http://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "exocrine component of pancreas" RELATED []
synonym: "exocrine pancreas" EXACT []
synonym: "exocrine part of pancreas" RELATED [BTO:0000434]
synonym: "pars exocrina pancreatis" EXACT []
xref: AAO:0010407
xref: BTO:0000434
xref: CALOHA:TS-1241
xref: EMAPA:35328
xref: EV:0100093
xref: FMA:16017
xref: MA:0002415
xref: MESH:D046790 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0001-9439-5346", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: NCIT:C32546
xref: SCTID:248202004
xref: TAO:0001249
xref: UMLS:C0553695 {source="ncithesaurus:Exocrine_Pancreas"}
xref: VHOG:0000048
xref: Wikipedia:Exocrine_component_of_pancreas
xref: XAO:0000137
xref: ZFA:0001249
is_a: UBERON:0000409 ! serous gland
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0005177 ! trunk region element
relationship: capable_of_part_of GO:0007586 ! digestion
relationship: contributes_to_morphology_of UBERON:0001264 ! pancreas
relationship: develops_from UBERON:0003924 ! ventral pancreatic bud
relationship: has_part UBERON:0001263 ! pancreatic acinus
relationship: has_part UBERON:0007329 ! pancreatic duct
relationship: part_of UBERON:0001264 ! pancreas
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001249", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/Pancreas"}
property_value: UBPROP:0000003 "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000048", ontology="VHOG", source="DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000018
name: compound eye
namespace: uberon
def: "A light sensing organ composed of ommatidia." [FB:gg, Wikipedia:Compound_eye]
subset: organ_slim
subset: uberon_slim
synonym: "adult compound eye" RELATED []
synonym: "faceted eye" RELATED []
synonym: "Facettenauge" RELATED [BTO:0001921]
synonym: "insect eye" RELATED []
synonym: "Komplexauge" RELATED [BTO:0001921]
synonym: "zusammengesetztes Auge" RELATED [BTO:0001921]
xref: BTO:0001921
xref: FBbt:00004508 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: HAO:0000217
xref: IDOMAL:0002421 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: TGMA:0000024
xref: Wikipedia:Compound_eye
is_a: UBERON:0015165 ! multi-unit eye
intersection_of: UBERON:0000970 ! eye
intersection_of: composed_primarily_of UBERON:0000971 ! ommatidium
relationship: composed_primarily_of UBERON:0000971 ! ommatidium
relationship: only_in_taxon NCBITaxon:6656 {source="PMID:21062451"} ! Arthropoda
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/457" xsd:anyURI
property_value: UBPROP:0000008 "The term compound eye is sometimes used for the multi-unit eyes of annelids, bivalves, echinoderms. We follow Richter et al and restrict this class to the arthropod structure for these structures" xsd:string {source="PMID:21062451"}

[Term]
id: UBERON:0000019
name: camera-type eye
namespace: uberon
def: "An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid." [GO:0043010, https://orcid.org/0000-0002-6601-2165]
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "camera-type eye plus associated structures" RELATED []
synonym: "eye" BROAD [FMA:54448]
synonym: "eyes" RELATED OMO:0003004 [TAO:0000107]
synonym: "orbital part of face" RELATED [FMA:54448]
synonym: "orbital region" RELATED [FMA:54448]
synonym: "regio orbitalis" EXACT OMO:0003011 [FMA:54448, FMA:TA]
synonym: "vertebrate eye" NARROW []
xref: AAO:0010340
xref: BIRNLEX:1169
xref: BTO:0004688
xref: EHDAA2:0000484
xref: EHDAA:936
xref: EMAPA:16198
xref: FMA:54448
xref: MA:0000261
xref: NCIT:C12401
xref: SCTID:181143004
xref: TAO:0000107
xref: UMLS:C0015392 {source="BIRNLEX:1169", source="ncithesaurus:Eye"}
xref: UMLS:C1280202 {source="BIRNLEX:1169"}
xref: VHOG:0000275
xref: XAO:0000179
xref: ZFA:0000107
is_a: UBERON:0000047 ! simple eye
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0015212 ! lateral structure
relationship: develops_from UBERON:0003072 {evidence="definitional"} ! optic cup
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: has_part UBERON:0000965 ! lens of camera-type eye
relationship: has_part UBERON:0000966 ! retina
relationship: in_lateral_side_of UBERON:0000033 ! head
relationship: part_of UBERON:0004088 ! orbital region
property_value: UBPROP:0000001 "A cavitated compound organ that transduces light waves into neural signals.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000107", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000275", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000020
name: sense organ
namespace: uberon
def: "An organ that is capable of transducing sensory stimulus to the nervous system." [https://github.com/obophenotype/uberon/issues/549, https://orcid.org/0000-0002-6601-2165]
subset: uberon_slim
synonym: "organ of sense organ system" EXACT [OBOL:accepted]
synonym: "organ of sensory organ system" EXACT [OBOL:accepted]
synonym: "organ of sensory system" EXACT [OBOL:accepted]
synonym: "sense organ system organ" EXACT [OBOL:automatic]
synonym: "sensillum" NARROW [WBbt:0006929]
synonym: "sensor" RELATED []
synonym: "sensory organ" EXACT []
synonym: "sensory organ system organ" EXACT [OBOL:automatic]
synonym: "sensory system organ" EXACT [OBOL:accepted]
synonym: "Sinnesorgan" RELATED [BTO:0000202]
xref: AEO:0000094
xref: BSA:0000121
xref: BTO:0000202
xref: CALOHA:TS-2043
xref: EHDAA2:0001824
xref: EHDAA:500
xref: EMAPA:35955
xref: FBbt:00005155 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: GAID:63
xref: HAO:0000930
xref: MA:0000017
xref: MESH:D012679
xref: NCIT:C33224
xref: SCTID:244485009
xref: UMLS:C0935626 {source="ncithesaurus:Organ_of_the_Special_Sense"}
xref: VHOG:0001407
xref: WBbt:0006929
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: capable_of GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of UBERON:0001032 ! sensory system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: x_1.1:contributor https://github.com/cmungall

[Term]
id: UBERON:0000025
name: tube
namespace: uberon
def: "Any hollow cylindrical anatomical structure containing a lumen through which substances are transported." [http://orcid.org/0000-0002-6601-2165]
synonym: "anatomical tube" EXACT []
synonym: "duct" NARROW []
xref: galen:Tube
is_a: UBERON:0004111 ! anatomical conduit
intersection_of: UBERON:0004111 ! anatomical conduit
intersection_of: has_quality PATO:0002299 ! tubular
relationship: has_part UBERON:0013522 ! subdivision of tube
relationship: has_quality PATO:0002299 ! tubular
property_value: curator_notes "not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts)" xsd:string
property_value: UBPROP:0000007 "tubular" xsd:string

[Term]
id: UBERON:0000026
name: appendage
namespace: uberon
def: "Major subdivision of an organism that protrudes from the body[DOS, CARO]." [CARO:DOS]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "appendages" RELATED OMO:0003004 [XAO:0000218]
synonym: "extremitaet" RELATED [BTO:0001492]
synonym: "extremity" RELATED []
synonym: "limbs/digits/tail" RELATED [MP:0000001]
xref: AEO:0000193
xref: BILA:0000018
xref: BTO:0001492
xref: CARO:0010003
xref: EFO:0000799
xref: EHDAA2:0003193
xref: EMAPA:37283 {source="MA:th"}
xref: EV:0100155
xref: FBbt:00007000 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: HAO:0000144
xref: MAT:0000023
xref: MESH:D005121
xref: MIAA:0000023
xref: NCIT:C61460
xref: UMLS:C0598782 {source="ncithesaurus:Appendage"}
xref: VSAO:0000075
xref: Wikipedia:Appendage
xref: XAO:0000218
is_a: UBERON:0000475 ! organism subdivision
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: UBPROP:0000001 "An appendage is an external body part, or natural prolongation, that protrudes from an organism's body, such as a vertebrate's limbs[BILA][BILA:0000018]." xsd:string {source="BILA:0000018"}
property_value: UBPROP:0000001 "Organ or organ part that is attached to the body of an organism. For example a limb[GO, modified][GO:0048736]." xsd:string {source="GO:0048736"}
property_value: UBPROP:0000007 "appendicular" xsd:string
property_value: UBPROP:0000008 "this is currently a subtype of organism subdivision - which would exclude feathers" xsd:string

[Term]
id: UBERON:0000030
name: lamina propria
namespace: uberon
def: "A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions." [Wikipedia:Lamina_propria]
subset: uberon_slim
synonym: "lamina propria mucosa" EXACT []
synonym: "lamina propria mucosae" EXACT []
synonym: "tunica propria" RELATED [BTO:0002330]
xref: BTO:0002330
xref: FMA:62517
xref: NCIT:C32918
xref: SCTID:298225002
xref: UMLS:C1179187 {source="ncithesaurus:Lamina_Propria"}
xref: Wikipedia:Lamina_propria
is_a: UBERON:0004923 ! organ component layer
relationship: composed_primarily_of UBERON:0011825 ! loose connective tissue
relationship: immediately_deep_to UBERON:0000483 ! epithelium
relationship: part_of UBERON:0000344 ! mucosa
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/f/fb/GI_Organization.svg" xsd:anyURI

[Term]
id: UBERON:0000031
name: lamina propria of trachea
namespace: uberon
def: "A lamina propria that is part of a respiratory airway." [OBOL:automatic]
synonym: "lamina propria mucosa of trachea" EXACT [OBOL:automatic]
synonym: "lamina propria mucosa of windpipe" EXACT [OBOL:automatic]
synonym: "lamina propria mucosae of trachea" EXACT [OBOL:automatic]
synonym: "lamina propria mucosae of windpipe" EXACT [OBOL:automatic]
synonym: "lamina propria of windpipe" EXACT [OBOL:automatic]
synonym: "trachea lamina propria" EXACT []
synonym: "trachea lamina propria mucosa" EXACT [OBOL:automatic]
synonym: "trachea lamina propria mucosae" EXACT [OBOL:automatic]
synonym: "tracheal lamina propria" EXACT []
synonym: "windpipe lamina propria" EXACT [OBOL:automatic]
synonym: "windpipe lamina propria mucosa" EXACT [OBOL:automatic]
synonym: "windpipe lamina propria mucosae" EXACT [OBOL:automatic]
xref: EMAPA:35877
xref: FMA:265157
xref: MA:0001858
xref: NCIT:C49305
xref: UMLS:C1710457 {source="ncithesaurus:Trachea_Lamina_Propria"}
is_a: UBERON:0004779 ! respiratory system lamina propria
intersection_of: UBERON:0000030 ! lamina propria
intersection_of: part_of UBERON:0001005 ! respiratory airway
relationship: part_of UBERON:0000379 {is_inferred="true", source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! tracheal mucosa

[Term]
id: UBERON:0000033
name: head
namespace: uberon
def: "The head is the anterior-most division of the body [GO]." [GO:0060322, Wikipedia:Head]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "adult head" NARROW []
synonym: "cephalic area" RELATED [SPD:0000016]
synonym: "head (volume)" EXACT [FMA:7154]
xref: AAO:0010335
xref: AEO:0000106
xref: BILA:0000115
xref: BIRNLEX:1230
xref: BTO:0000282
xref: CALOHA:TS-0436
xref: EFO:0000964
xref: EHDAA2:0003106
xref: EMAPA:31858
xref: FMA:7154
xref: GAID:61
xref: galen:Head
xref: HAO:0000397
xref: MA:0000023
xref: MAT:0000294
xref: MESH:D006257
xref: MIAA:0000294
xref: NCIT:C12419
xref: SCTID:302548004
xref: SPD:0000016
xref: TAO:0001114
xref: TGMA:0000002
xref: UMLS:C0018670 {source="ncithesaurus:Head", source="BIRNLEX:1230"}
xref: VHOG:0001644
xref: WBbt:0005739
xref: Wikipedia:Head
xref: XAO:0003024
xref: ZFA:0001114
is_a: UBERON:0011676 ! subdivision of organism along main body axis
relationship: has_skeleton UBERON:0003129 {gci_relation="part_of", gci_filler="NCBITaxon:7776"} ! skull
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0007811 ! craniocervical region
property_value: RO:0002171 UBERON:0000948
property_value: UBPROP:0000001 "Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010335", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001114", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001644", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.82", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000042
name: serous membrane
namespace: uberon
def: "Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer." [https://github.com/obophenotype/uberon/issues/86, Wikipedia:Serous_membrane]
subset: uberon_slim
subset: vertebrate_core
synonym: "serosa" RELATED [Wikipedia:Serous_membrane]
synonym: "tunica serosa" EXACT OMO:0003011 [FMA:9581]
synonym: "wall of serous sac" EXACT [FMA:9581]
xref: FMA:9581
xref: GAID:19
xref: MESH:D012704
xref: NCIT:C13169
xref: SCTID:362878009
xref: TAO:0005425
xref: UMLS:C0036760 {source="ncithesaurus:Serosa"}
xref: Wikipedia:Serous_membrane
xref: ZFA:0005425
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: has_part UBERON:0001136 ! mesothelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: part_of NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000060 ! anatomical wall
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: UBPROP:0000001 "A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005425", ontology="TAO", source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000001 "a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP]" xsd:string {source="Wikipedia:Serous_membrane"}
property_value: UBPROP:0000012 "in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA." xsd:string {external_ontology="FMA"}
property_value: x_1.1:contributor https://github.com/cmungall

[Term]
id: UBERON:0000043
name: tendon
namespace: uberon
def: "Dense regular connective tissue that connects muscle to bone[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073, Wikipedia:Tendon]
subset: pheno_slim
subset: uberon_slim
synonym: "sinew" RELATED [Wikipedia:Tendon]
synonym: "tendo" RELATED OMO:0003011 [Wikipedia:Tendon]
xref: AEO:0000091
xref: BTO:0001356
xref: CALOHA:TS-1021
xref: EHDAA2:0003091
xref: EMAPA:35854
xref: EV:0100149
xref: FMA:9721
xref: GAID:276
xref: galen:Tendon
xref: MA:0000115
xref: MESH:D013710
xref: NCIT:C13045
xref: SCTID:256667004
xref: UMLS:C0039508 {source="ncithesaurus:Tendon"}
xref: VHOG:0001286
xref: VSAO:0000073
xref: Wikipedia:Tendon
xref: XAO:0000173
xref: ZFA:0005647
is_a: UBERON:0007846 {source="VSAO"} ! dense regular connective tissue
relationship: connects UBERON:0001474 ! bone element
relationship: connects UBERON:0001630 ! muscle organ
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0002204 {source="OG"} ! musculoskeletal system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Dense regular connective tissue that connects muscle to bone.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000073", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000003 "Phylogenetically, tendinous tissue first appears in the invertebrate chordate Branchiostoma as myosepta. This two-dimensional array of collagen fibers is highly organized, with fibers running along two primary axes. In hagfish the first linear tendons appear and the myosepta have developed specialized regions with unidirectional fiber orientation - a linear tendon within the flat sheet of myoseptum.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001286", ontology="VHOG", source="DOI:10.1016/S1095-6433(02)00241-6 Summers AP, Koob TJ, The evolution of tendon - morphology and material properties. Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology (2002)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in FMA, tendon is an organ component that with parts dense-irregular-connective-tissue of tendon and dense-irregular-connective-tissue of tendon sheath; we follow VSAO in making it a subtype of the former. In VSAO tendons connect muscle to bone; in WP the def states integument (e.g. auricular muscles) - but JB confirms this is not actually tendon but aponeurosis" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000045
name: ganglion
namespace: uberon
def: "A biological tissue mass, most commonly a mass of nerve cell bodies." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Ganglion]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "ganglia" RELATED []
synonym: "neural ganglion" RELATED [BTO:0000497]
xref: AAO:0010426
xref: AEO:0000135
xref: BAMS:G
xref: BTO:0000497
xref: CALOHA:TS-0397
xref: EFO:0000899
xref: EHDAA2:0003135
xref: EHDAA:2897
xref: EHDAA:4662
xref: EHDAA:5621
xref: EHDAA:918
xref: EMAPA:32846
xref: EV:0100372
xref: FMA:5884
xref: MA:0002406
xref: MAT:0000207
xref: MAT:0000343
xref: MESH:D005724
xref: MIAA:0000207
xref: MIAA:0000343
xref: NCIT:C12719
xref: NLXANAT:100302
xref: TAO:0000190
xref: TGMA:0001016
xref: UMLS:C0017067 {source="ncithesaurus:Ganglion"}
xref: VHOG:0000156
xref: WBbt:0005189
xref: Wikipedia:Ganglion
xref: XAO:0000209
xref: ZFA:0000190
is_a: UBERON:0000061 {source="https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719"} ! anatomical structure
relationship: composed_primarily_of UBERON:0003714 {source="EHDAA2"} ! neural tissue
relationship: develops_from UBERON:0003869 ! presumptive ganglion
relationship: immediate_transformation_of UBERON:0003869 {source="Bgee:AN"} ! presumptive ganglion
relationship: part_of UBERON:0001016 ! nervous system
property_value: editor_note "TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system." xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures" xsd:string {source="PMID:21062451"}
property_value: UBPROP:0000001 "Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010426", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000190", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302]." xsd:string {source="NLXANAT:100302"}
property_value: UBPROP:0000003 "Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000156", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.02.021 Mazet F, Hutt JA, Milloz J, Millard J, Graham A, Shimeld SM, Molecular evidence from Ciona intestinalis for the evolutionary origin of vertebrate sensory placodes. Developmental Biology (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ganglionic" xsd:string
property_value: x_1.1:contributor https://github.com/cmungall

[Term]
id: UBERON:0000046
name: stemma
name: stemma {def="Eye-spots which may be set into a pit to reduce the angles of light that enters and affects the eyespot, to allow the organism to deduce the angle of incoming light. \n[http://en.wikipedia.org/wiki/Stemma http://en.wikipedia.org/wiki/Eye#Pit_eyes]"}
namespace: uberon
def: "Eye-spots which may be set into a pit to reduce the angles of light that enters and affects the eyespot, to allow the organism to deduce the angle of incoming light." [Wikipedia:Eye#Pit_eyes, Wikipedia:Stemma]
subset: uberon_slim
synonym: "pit eye" EXACT [Wikipedia:Eye#Pit_eyes]
xref: Wikipedia:Stemma
is_a: UBERON:0000047 ! simple eye
property_value: AISM:0000171 "Beutel RG, Friedrich F, Yang X-K, Ge S-Q (2014) Insect Morphology and Phylogeny Insect morphology and phylogeny: a textbook for students of entomology. De Gruyter.\n\nhttps://doi.org/10.1515/9783110264043\n\n\"Stemmata are specific lateral eyes (the term “lateral ocelli” is inappropriate) of larvae of most groups of Holometabola. They are replaced by the adult compound eyes during the metamorphosis. The number ranges between seven and one and they are absent in different groups. Structurally, they resemble ommatidia and are suitable to perceive movements, directions and distances.\"" xsd:string
property_value: RO:0002161 NCBITaxon:7742

[Term]
id: UBERON:0000047
name: simple eye
namespace: uberon
def: "An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity." [Wikipedia:Eye#Simple_eyes]
subset: grouping_class
subset: uberon_slim
xref: TGMA:0000729
xref: Wikipedia:Eye#Simple_eyes
is_a: UBERON:0000970 ! eye

[Term]
id: UBERON:0000055
name: vessel
namespace: uberon
def: "A tubular structure that contains, conveys body fluid, such as blood or lymph." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
subset: human_reference_atlas
subset: pheno_slim
is_a: UBERON:0004111 ! anatomical conduit
relationship: channel_for UBERON:0006314 ! bodily fluid
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000056
name: ureter
namespace: uberon
def: "Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs." [GO:0090189, Wikipedia:Ureter]
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
synonym: "metanephric duct" RELATED [ISBN:0073040584, VHOG:0000605]
xref: AAO:0010254
xref: BTO:0001409
xref: CALOHA:TS-1084
xref: EFO:0000930
xref: EHDAA2:0002139
xref: EHDAA:9341
xref: EMAPA:17950
xref: EV:0100097
xref: FMA:9704
xref: GAID:438
xref: galen:Ureter
xref: MA:0000378
xref: MAT:0000120
xref: MESH:D014513
xref: MIAA:0000120
xref: NCIT:C12416
xref: SCTID:302511008
xref: UMLS:C0041951 {source="ncithesaurus:Ureter"}
xref: VHOG:0000605
xref: Wikipedia:Ureter
xref: XAO:0000144
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005179 ! pelvic region element
is_a: UBERON:0006555 ! excretory tube
is_a: UBERON:0015212 ! lateral structure
relationship: channel_for UBERON:0001088 ! urine
relationship: channels_from UBERON:0001224 ! renal pelvis
relationship: channels_into UBERON:0001255 ! urinary bladder
relationship: develops_from UBERON:0005081 {source="GO"} ! ureter ureteric bud
relationship: in_lateral_side_of UBERON:0000468 ! multicellular organism
relationship: part_of UBERON:0036295 ! renal pelvis/ureter
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/3/30/Urinary_system.svg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Anatomical structure consisting of long narrow duct which carries urine from the kidney to the urinary bladder.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010254", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The duct of amniotes that carries urine from a metanephric kidney to the urinary bladder. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-29, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000605", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ureteral" xsd:string
property_value: UBPROP:0000007 "ureteric" xsd:string
property_value: UBPROP:0000010 "in humans, consists of adventitial, muscular and mucoa layers" xsd:string

[Term]
id: UBERON:0000057
name: urethra
namespace: uberon
def: "The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening." [MGI:anna, MP:0000537]
subset: efo_slim
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
xref: BTO:0001426
xref: CALOHA:TS-1132
xref: EFO:0000931
xref: EMAPA:30901
xref: EV:0100099
xref: FMA:19667
xref: GAID:390
xref: galen:Urethra
xref: MA:0000379
xref: MAT:0000121
xref: MESH:D014521
xref: MIAA:0000121
xref: NCIT:C12417
xref: SCTID:302513006
xref: UMLS:C0041967 {source="ncithesaurus:Urethra"}
xref: VHOG:0001264
xref: Wikipedia:Urethra
xref: XAO:0000153
is_a: UBERON:0000062 ! organ
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: capable_of_part_of GO:0060073 ! micturition
relationship: channel_for UBERON:0001088 ! urine
relationship: channels_from UBERON:0001255 ! urinary bladder
relationship: continuous_with UBERON:0001255 ! urinary bladder
relationship: develops_from UBERON:0000164 {notes="pelvic part of UG sinus gives rise to prostatic and membranous parts of urethra", source="Wikipedia"} ! primitive urogenital sinus
relationship: develops_from UBERON:0013241 {source="Wikipedia"} ! embryonic urethral groove
relationship: part_of UBERON:0001556 ! lower urinary tract
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: UBPROP:0000007 "urethral" xsd:string
property_value: UBPROP:0000008 "In human males, the urethra travels through the penis, and carries semen as well as urine. In females, the urethra is shorter and emerges above the vaginal opening." xsd:string

[Term]
id: UBERON:0000058
name: duct
namespace: uberon
def: "A tubular structure that transports secreted or excreted substances." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm#ducts]
subset: grouping_class
synonym: "anatomical duct" EXACT []
synonym: "ducts" RELATED OMO:0003004 [XAO:0004000]
synonym: "exocrine duct" NARROW []
synonym: "exocrine gland duct" NARROW []
xref: AAO:0011123
xref: FBbt:00100314 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:30320
xref: galen:Duct
xref: NCIT:C12948
xref: SCTID:91726008
xref: TAO:0005171
xref: UMLS:C0687028 {source="ncithesaurus:Duct"}
xref: Wikipedia:Duct_(anatomy)
xref: XAO:0004000
xref: ZFA:0005171
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000063 ! organ subunit
relationship: conduit_for UBERON:0000463 ! organism substance
relationship: has_part UBERON:0034969 ! epithelial layer of duct
relationship: has_quality PATO:0002299 ! tubular
property_value: UBPROP:0000001 "A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]." xsd:string {source="ZFA:0005171"}
property_value: UBPROP:0000012 "Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here." xsd:string

[Term]
id: UBERON:0000059
name: large intestine
namespace: uberon
def: "A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]." [ISBN:0073040584, Wikipedia:Large_intestine_(anatomy)]
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: pheno_slim
synonym: "intestinum crassum" RELATED [BTO:0000706]
xref: AAO:0010396
xref: BTO:0000706
xref: CALOHA:TS-1306
xref: EFO:0000840
xref: EMAPA:19252
xref: EV:0100077
xref: FMA:7201
xref: GAID:306
xref: galen:LargeIntestine
xref: MA:0000333
xref: MESH:D007420
xref: MIAA:0000046
xref: NCIT:C12379
xref: SCTID:181254001
xref: UMLS:C0021851 {source="ncithesaurus:Large_Intestine"}
xref: VHOG:0000054
xref: Wikipedia:Large_intestine_(anatomy)
xref: XAO:0000131
is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract
is_a: UBERON:0013765 ! digestive system element
relationship: contributes_to_morphology_of UBERON:0000160 ! intestine
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0000160 ! intestine
relationship: part_of UBERON:0004907 ! lower digestive tract
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/SBU_F_Intestine_Large.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "Intestinal surface area also is increased in amphibians and reptiles by internal folds and occasionally by a few villi. The intestine can be divided into a small intestine and a slightly wider large intestine.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000054", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.566", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000060
name: anatomical wall
namespace: uberon
alt_id: UBERON:0009915
def: "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers." [FMA:82482]
subset: upper_level
synonym: "organ wall" RELATED [FMA:82482]
synonym: "wall" BROAD []
synonym: "wall of organ" EXACT [FMA:82482]
xref: EMAPA:25036
xref: FMA:82482
xref: galen:Wall
is_a: UBERON:0000064 ! organ part
relationship: adjacent_to UBERON:0002553 ! anatomical cavity
relationship: has_part UBERON:0004923 ! organ component layer
property_value: UBPROP:0000012 "in FMA, serosa is a wall" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000061
name: anatomical structure
namespace: uberon
def: "Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome." [CARO:0000003]
subset: common_anatomy
subset: human_subset
subset: mouse_subset
subset: upper_level
synonym: "biological structure" EXACT []
synonym: "connected biological structure" EXACT [CARO:0000003]
xref: AAO:0010825
xref: AEO:0000003
xref: BILA:0000003
xref: CARO:0000003
xref: EHDAA2:0003003
xref: EMAPA:0
xref: FBbt:00007001 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:305751
xref: FMA:67135
xref: GAID:781
xref: HAO:0000003
xref: http://dbpedia.org/ontology/AnatomicalStructure
xref: MA:0003000
xref: MESH:D000825
xref: SCTID:362889002
xref: TAO:0000037
xref: TGMA:0001823
xref: VHOG:0001759
xref: XAO:0003000
xref: ZFA:0000037
is_a: UBERON:0000465 ! material anatomical entity
relationship: existence_ends_during_or_before UBERON:0000071 ! death stage
relationship: existence_starts_during_or_after UBERON:0000106 {gci_relation="in_taxon", gci_filler="NCBITaxon:33208"} ! zygote stage
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000062
name: organ
namespace: uberon
def: "Anatomical structure that performs a specific function or group of functions [WP]." [Wikipedia:Organ_(anatomy)]
subset: common_anatomy
subset: upper_level
synonym: "anatomical unit" RELATED []
synonym: "body organ" RELATED []
synonym: "element" RELATED [http://orcid.org/0000-0002-6601-2165]
xref: BIRNLEX:4
xref: CARO:0020004
xref: EFO:0000634
xref: EMAPA:35949
xref: ENVO:01000162
xref: FMA:67498
xref: MA:0003001
xref: NCIT:C13018
xref: SCTID:272625005
xref: UMLS:C0178784 {source="ncithesaurus:Organ"}
xref: WBbt:0003760
xref: Wikipedia:Organ_(anatomy)
is_a: UBERON:0010000 ! multicellular anatomical structure
disjoint_from: UBERON:0002095 {source="PMID:28192867"} ! mesentery
disjoint_from: UBERON:0034921 ! multi organ part structure
relationship: capable_of GO:0008150 ! biological process
relationship: existence_starts_during_or_after UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! organogenesis stage
relationship: has_boundary UBERON:0006984 ! anatomical surface
relationship: part_of UBERON:0000467 ! anatomical system
property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"}
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: UBPROP:0000001 "Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." xsd:string {source="GO:0048513"}
property_value: UBPROP:0000012 "CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4" xsd:string

[Term]
id: UBERON:0000063
name: organ subunit
namespace: uberon
def: "A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity." [http://orcid.org/0000-0002-6601-2165]
subset: upper_level
synonym: "organ region with fixed fiat boundary" RELATED [FMA:86140]
synonym: "organ segment" RELATED [FMA:86140]
synonym: "segment of organ" RELATED [FMA:86140]
xref: FMA:86140
is_a: UBERON:0000064 ! organ part
property_value: editor_note "FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction" xsd:string
property_value: UBPROP:0000001 "Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball." xsd:string {source="FMA:86140", version="3"}
property_value: UBPROP:0000001 "Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal." xsd:string {source="FMA:86140", version="1"}

[Term]
id: UBERON:0000064
name: organ part
namespace: uberon
def: "A multicellular structure that is a part of an organ." [http://orcid.org/0000-0002-6601-2165]
subset: common_anatomy
subset: efo_slim
subset: non_informative
subset: upper_level
synonym: "cardinal organ part" EXACT [FMA:82472]
synonym: "regional part of organ" RELATED [BIRNLEX:16]
xref: AAO:0011124
xref: BIRNLEX:16
xref: EFO:0000635
xref: FMA:82472
xref: SCTID:113343008
xref: SCTID:91717005
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: part_of UBERON:0000062 ! organ
property_value: curator_notes "currently defined in a very broad sense, may be replaced by more specific classes in the future" xsd:string
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000065
name: respiratory tract
namespace: uberon
def: "Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts." [https://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
xref: EHDAA2:0001606
xref: EHDAA:1568
xref: EHDAA:2219
xref: EMAPA:16737
xref: FMA:265130
xref: SCTID:361110005
xref: VHOG:0000393
is_a: UBERON:0001005 ! respiratory airway
is_a: UBERON:0004119 ! endoderm-derived structure
relationship: develops_from UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut
relationship: develops_from UBERON:0008947 ! respiratory primordium
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000066
name: fully formed stage
namespace: uberon
def: "The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage." [https://orcid.org/0000-0002-6601-2165]
subset: efo_slim
synonym: "adult stage" BROAD []
synonym: "fully formed animal stage" EXACT []
synonym: "juvenile-adult stage" EXACT []
xref: BilaDO:0000004
xref: BTO:0001043
xref: EFO:0001272
xref: FBdv:00005369
xref: WBls:0000041
xref: XtroDO:0000084
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000092 ! post-embryonic stage
relationship: preceded_by UBERON:0000111 ! organogenesis stage
relationship: preceded_by UBERON:0004729 {gci_relation="part_of", gci_filler="NCBITaxon:6239"} ! nematode larval stage
relationship: precedes UBERON:0000071 ! death stage
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/566" xsd:anyURI

[Term]
id: UBERON:0000068
name: embryo stage
namespace: uberon
def: "A life cycle stage that starts with fertilization and ends with the fully formed embryo." [http://orcid.org/0000-0002-6601-2165]
synonym: "embryogenesis" RELATED []
synonym: "embryonic stage" EXACT []
xref: BilaDO:0000002
xref: EV:0300001
xref: FBdv:00005289
xref: FMA:72652
xref: HsapDv:0000002
xref: MmusDv:0000002
xref: OGES:000000
xref: OGES:000022
xref: SCTID:296280003
xref: WBls:0000003
xref: WBls:0000092
xref: WBls:0000102
xref: XAO:1000012
is_a: UBERON:0000105 ! life cycle stage
disjoint_from: UBERON:0000092 ! post-embryonic stage
relationship: precedes UBERON:0000066 ! fully formed stage
relationship: precedes UBERON:0000092 ! post-embryonic stage
relationship: simultaneous_with GO:0009790 ! embryo development

[Term]
id: UBERON:0000069
name: larval stage
namespace: uberon
def: "A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle." [Wikipedia:Larva]
subset: efo_slim
synonym: "ammocoete" NARROW SENSU [Wikipedia:Larva]
synonym: "ammocoete stage" NARROW SENSU [Wikipedia:Larva]
synonym: "bipinnaria" NARROW SENSU [Wikipedia:Larva]
synonym: "bipinnaria stage" NARROW SENSU [Wikipedia:Larva]
synonym: "caterpillar" NARROW SENSU [Wikipedia:Larva]
synonym: "caterpillar stage" NARROW SENSU [Wikipedia:Larva]
synonym: "glochidium" NARROW SENSU [Wikipedia:Larva]
synonym: "glochidium stage" NARROW SENSU [Wikipedia:Larva]
synonym: "grub" NARROW SENSU [Wikipedia:Larva]
synonym: "grub stage" NARROW SENSU [Wikipedia:Larva]
synonym: "larva" RELATED []
synonym: "larva stage" EXACT []
synonym: "leptocephalus" NARROW SENSU [Wikipedia:Larva]
synonym: "leptocephalus stage" NARROW SENSU [Wikipedia:Larva]
synonym: "maggot" NARROW SENSU [Wikipedia:Larva]
synonym: "maggot stage" NARROW SENSU [Wikipedia:Larva]
synonym: "metacestode" NARROW SENSU [BTO:0000859]
synonym: "naiad, nymph" NARROW SENSU [Wikipedia:Larva]
synonym: "naiad, nymph stage" NARROW SENSU [Wikipedia:Larva]
synonym: "nauplius" NARROW SENSU [Wikipedia:Larva]
synonym: "nauplius stage" NARROW SENSU [Wikipedia:Larva]
synonym: "nymph" NARROW SENSU [Wikipedia:Larva]
synonym: "nymph stage" NARROW SENSU [Wikipedia:Larva]
synonym: "planula" NARROW SENSU [Wikipedia:Larva]
synonym: "planula stage" NARROW SENSU [Wikipedia:Larva]
synonym: "tornaria" NARROW SENSU [NCBITaxon:10219]
synonym: "trochophore" NARROW SENSU [Wikipedia:Larva]
synonym: "trochophore stage" NARROW SENSU [Wikipedia:Larva]
synonym: "veliger" NARROW SENSU [Wikipedia:Larva]
synonym: "veliger stage" NARROW SENSU [Wikipedia:Larva]
synonym: "wriggler" NARROW SENSU [Wikipedia:Larva]
synonym: "wriggler stage" NARROW SENSU [Wikipedia:Larva]
synonym: "zoea" NARROW SENSU [Wikipedia:Larva]
synonym: "zoea stage" NARROW SENSU [Wikipedia:Larva]
xref: BTO:0000915
xref: BTO:0000954
xref: EFO:0001303
xref: FBdv:00005336
xref: MIAA:0000400
xref: OGES:000008
xref: Wikipedia:Larva
xref: ZFS:0000048
is_a: UBERON:0000105 ! life cycle stage
relationship: immediately_preceded_by UBERON:0000068 ! embryo stage
relationship: part_of UBERON:0000092 ! post-embryonic stage
relationship: simultaneous_with GO:0002164 ! larval development
property_value: curator_notes "Uberon includes clade-specific subclasses, e.g. nematod larva" xsd:string
property_value: RO:0002161 NCBITaxon:32524
property_value: UBPROP:0000008 "It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form" xsd:string {source="WP"}

[Term]
id: UBERON:0000071
name: death stage
namespace: uberon
def: "End of the life of an organism." [XAO:0000437]
subset: common_anatomy
synonym: "death" RELATED []
xref: XAO:0000437
xref: XtroDO:0000085
is_a: UBERON:0000105 ! life cycle stage
relationship: ends UBERON:0000104 ! life cycle
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: UBPROP:0000012 "ncit:Death is an outcome" xsd:string {external_ontology="ncit"}

[Term]
id: UBERON:0000072
name: proximo-distal subdivision of respiratory tract
namespace: uberon
def: "An section of a respiratory tract." [http://orcid.org/0000-0002-6601-2165]
subset: non_informative
synonym: "respiratory tract" RELATED [MA:0000434]
synonym: "subdivision of respiratory tract" RELATED []
xref: EMAPA:16737
xref: FMA:45660
xref: MA:0000434
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0013522 ! subdivision of tube
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: part_of UBERON:0000065 ! respiratory tract
property_value: UBPROP:0000012 "MA:0000434 has subclasses upper and lower, so it corresponds to a segment of the tract, rather than the tract as a whole" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0000073
name: regional part of nervous system
namespace: uberon
def: "Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS." [BIRNLEX:1157]
subset: non_informative
subset: upper_level
synonym: "part of nervous system" EXACT [BIRNLEX:1157]
xref: BIRNLEX:1157
xref: NCIT:C13040
xref: SCTID:25087005
xref: UMLS:C1518256 {source="ncithesaurus:Nervous_System_Part"}
is_a: UBERON:0000481 ! multi-tissue structure
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0001016 ! nervous system
relationship: part_of NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0001016 ! nervous system
property_value: term:contributor https://orcid.org/0000-0001-9114-8737
creation_date: 2009-06-18T09:00:04Z

[Term]
id: UBERON:0000075
name: subdivision of skeletal system
namespace: uberon
alt_id: UBERON:0010322
def: "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism." [https://orcid.org/0000-0002-6601-2165, UBERONREF:0000003]
subset: non_informative
synonym: "skeletal system part" RELATED []
synonym: "skeletal system subdivision" EXACT [FMA:85544]
xref: FMA:85544
xref: galen:ComplexSkeletalStructure
xref: NCIT:C34076
xref: SCTID:118966000
xref: UMLS:C1519343 {source="ncithesaurus:Skeletal_System_Part"}
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: composed_primarily_of UBERON:0004765 ! skeletal element
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0001434 ! skeletal system

[Term]
id: UBERON:0000076
name: external ectoderm
namespace: uberon
def: "The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm." [MGI:anna, MP:0012532]
subset: pheno_slim
synonym: "surface (external) ectoderm" EXACT []
synonym: "surface ectoderm" EXACT [MP:0012532]
xref: BTO:0006242 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: EHDAA2:0001968
xref: EHDAA:1494
xref: EHDAA:350
xref: EHDAA:4784
xref: EHDAA:4790
xref: EHDAA:4796
xref: EHDAA:7860
xref: EMAPA:16096
xref: FMA:87656
xref: NCIT:C34309
xref: UMLS:C1515087 {source="ncithesaurus:Surface_Ectoderm"}
xref: Wikipedia:External_ectoderm
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: part_of UBERON:0000924 {source="EHDAA2"} ! ectoderm
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png" xsd:anyURI
property_value: editor_note "merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)" xsd:string
property_value: RO:0002171 UBERON:0002346
property_value: UBPROP:0000011 "(or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis" xsd:string

[Term]
id: UBERON:0000077
name: mixed endoderm/mesoderm-derived structure
namespace: uberon
def: "An anatomical structure that develops from the endoderm and the mesoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0004120 ! mesoderm-derived structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: develops_from UBERON:0000926 ! mesoderm
property_value: curator_notes "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" xsd:string

[Term]
id: UBERON:0000078
name: mixed ectoderm/mesoderm/endoderm-derived structure
namespace: uberon
def: "An anatomical structure that develops from the ectoderm, mesoderm and endoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
intersection_of: develops_from UBERON:0000925 ! endoderm
intersection_of: develops_from UBERON:0000926 ! mesoderm
property_value: curator_notes "Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple" xsd:string

[Term]
id: UBERON:0000079
name: male reproductive system
namespace: uberon
def: "The organs associated with producing offspring in the gender that produces spermatozoa." [MP:0001145]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
synonym: "genitalia of male organism" EXACT [OBOL:automatic]
synonym: "male genital organ" RELATED [BTO:0000082]
synonym: "male genital system" EXACT [FMA:45664]
synonym: "male genital tract" RELATED []
synonym: "male genitalia" EXACT []
synonym: "male genitals" EXACT []
synonym: "male organism genitalia" EXACT [OBOL:automatic]
synonym: "male organism reproductive system" EXACT [OBOL:automatic]
synonym: "male reproductive tract" RELATED [MA:0000396]
synonym: "reproductive system of male organism" EXACT [OBOL:automatic]
synonym: "systema genitale masculinum" RELATED [BTO:0000082]
xref: BTO:0000082
xref: CALOHA:TS-1310
xref: EFO:0000970
xref: EHDAA2:0001054
xref: EHDAA:8136
xref: EMAPA:17968
xref: EV:0100101
xref: FBbt:00004927 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45664
xref: GAID:386
xref: HAO:0000505
xref: MA:0000396
xref: MESH:D005837
xref: NCIT:C12722
xref: SCTID:361340001
xref: TGMA:0000634
xref: UMLS:C0017422 {source="ncithesaurus:Male_Genitalia"}
xref: UMLS:C1963704 {source="ncithesaurus:Male_Reproductive_System"}
xref: VHOG:0000725
xref: Wikipedia:Male_reproductive_system_(human)
xref: XAO:0000155
is_a: UBERON:0000990 ! reproductive system
intersection_of: UBERON:0000990 ! reproductive system
intersection_of: part_of UBERON:0003101 ! male organism
disjoint_from: UBERON:0000474 ! female reproductive system
relationship: part_of UBERON:0003101 ! male organism
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000725", ontology="VHOG", source="ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000080
name: mesonephros
namespace: uberon
def: "The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo." [GO:0001823, Wikipedia:Mesonephros]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: vertebrate_core
synonym: "amphibian adult kidney" RELATED [XAO:0000141]
synonym: "corpus Wolffi" RELATED [BTO:0001542]
synonym: "mesonephric kidney" EXACT [XAO:0000141]
synonym: "mesonephroi" EXACT OMO:0003004 [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron]
synonym: "middle kidney" RELATED [BTO:0001542]
synonym: "opisthonephros" RELATED [VHOG:0000038, XAO:0000141]
synonym: "opisto nephros" RELATED []
synonym: "opistonephros" RELATED [http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html]
synonym: "Wolffian body" EXACT [BTO:0001542, GOC:yaf, MESH:A16.254.500, Wikipedia:Mesonephros]
xref: AAO:0010384
xref: BTO:0001542
xref: CALOHA:TS-0624
xref: EFO:0000928
xref: EHDAA2:0001130
xref: EHDAA:1581
xref: EHDAA:5903
xref: EMAPA:16744
xref: FMA:72171
xref: GAID:1308
xref: MESH:D001755
xref: NCIT:C26467
xref: SCTID:308799002
xref: TAO:0000529
xref: UMLS:C0025492 {source="ncithesaurus:Mesonephros"}
xref: VHOG:0000038
xref: Wikipedia:Mesonephros
xref: XAO:0000141
xref: ZFA:0000529
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0002120 ! pronephros
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/a/ad/Gray986.png" xsd:anyURI
property_value: UBPROP:0000001 "A kidney formed of nephric tubules arising in the middle region of the nephric ridge; a transient embryonic stage that replaces the pronephros, but is itself replaced by the adult metanephros [in mammals; in fishes and amphibians it is the adult kidney]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000038", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Organ that is the definitive adult kidney. It replaces the earlier pronephros, which degenerates as the mesonephros becomes functional in feeding stage tadpoles.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010384", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates. (...) In all vertebrate embryos, the kidney begins with the differentiation of a few renal tubules from the anterior end of the nephric ridge overlying the pericardial cavity. (...) This early-developing embryonic kidney is called the pronephros.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000038", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesonephric" xsd:string
property_value: UBPROP:0000008 "In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In fish and amphibians, the mesonephros will form the mature kidney" xsd:string
property_value: UBPROP:0000009 "By contrast to the pronephros, the histological features of the mammalian mesonephros, with its primitive glomeruli, suggest that it probably functions as a primitive kidney, and is involved in the production of much of the amniotic fluid. Within the two mesonephroi, one located on either side of the dorsal mesentery of the hindgut, a substantial number (in the region of about 40 or more) of cranio-caudally segmented mesonephric tubules are formed. It has, however, been suggested that only the most rostrally located 4-6 pairs of mesonephric tubules drain into the mesonephric portion of the nephric duct. This is now seen to extend along the length of the mesonephroi, being located towards their lateral sides. The mesonephros is also retained over a considerably longer period than the pronephros, but gradually undergoes regression in a cranio-caudal direction. While the rostral part displays clear evidence of regression its more caudal part appears to display evidence of functional activity. Within the medial part of the mesonephros, vesicles are formed, although no glomeruli are formed there in this species. It is, however, difficult to believe that the relatively enormous mesonephroi do not have an excretory role in the mouse, only serving as a base for gonadal differentiation. In the human embryo, the medial part of the mesonephric tubules enlarges, become invaginated by capillaries, and form glomeruli. These then take on an excretory role. In the mouse, the mesonephric ducts appear to be patent throughout their length[GUDMAP, modified]" xsd:string

[Term]
id: UBERON:0000081
name: metanephros
namespace: uberon
def: "In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO]." [GO:0001656, Wikipedia:Metanephros#Metanephros]
subset: organ_slim
subset: pheno_slim
synonym: "definite kidney" RELATED [BTO:0001543]
synonym: "definitive kidney" RELATED [BTO:0001543]
synonym: "hind kidney" RELATED [BTO:0001543]
synonym: "metanephric kidney" RELATED [VHOG:0000039]
synonym: "metanephron" EXACT [BTO:0001543]
xref: BTO:0001543
xref: EHDAA2:0001137
xref: EHDAA:3089
xref: EHDAA:5911
xref: EMAPA:17373
xref: EMAPA_RETIRED:17207
xref: FMA:72172
xref: NCIT:C34209
xref: SCTID:308797000
xref: UMLS:C0231049 {source="ncithesaurus:Metanephros"}
xref: VHOG:0000039
xref: Wikipedia:Metanephros#Metanephros
is_a: UBERON:0002113 ! kidney
is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: developmentally_replaces UBERON:0000080 {source="ISBN:9780878932504"} ! mesonephros
relationship: develops_from UBERON:0003220 {evidence="definitional"} ! metanephric mesenchyme
relationship: develops_from UBERON:0005080 {source="GO"} ! metanephric ureteric bud
relationship: develops_from UBERON:0005753 ! caudal part of nephrogenic cord
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
property_value: editor_note "TODO check developmental relationships" xsd:string
property_value: UBPROP:0000001 "A kidney formed of nephric tubules arising in the posterior region of the nephric ridge and drained by a ureter; replaces the embryonic pronephros and mesonephros [in mammals]. [Evolution, Fourth_Edition_(2006)_McGraw-Hill, Function, Kardong_KV, Vertebrates:_Comparative_Anatomy, p.745][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000039", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000039", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "metanephric" xsd:string
property_value: UBPROP:0000011 "During the fifth week of gestation, the mesonephric duct develops an outpouching, the ureteric bud, near its attachment to the cloaca. This bud, also called the metanephrogenic diverticulum, grows posteriorly and towards the head of the embryo. The elongated stalk of the ureteric bud, the metanephric duct, later forms the ureter. As the cranial end of the bud extends into the intermediate mesoderm, it undergoes a series of branchings to form the collecting duct system of the kidney. It also forms the major and minor calyces and the renal pelvis" xsd:string

[Term]
id: UBERON:0000083
name: mesonephric tubule
namespace: uberon
def: "A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]." [Wikipedia:Mesonephric_tubules]
synonym: "renal tubules" RELATED OMO:0003004 [VHOG:0000500]
synonym: "tubuli mesonephrici" RELATED OMO:0003011 [Wikipedia:Mesonephric_tubules]
xref: AAO:0010389
xref: EHDAA2:0001134
xref: EMAPA:16747
xref: VHOG:0000500
xref: Wikipedia:Mesonephric_tubules
xref: XAO:0000148
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0005103 ! mesonephric epithelium
is_a: UBERON:0006555 ! excretory tube
intersection_of: UBERON:0003914 ! epithelial tube
intersection_of: part_of UBERON:0000080 ! mesonephros
property_value: editor_note "TODO check" xsd:string
property_value: UBPROP:0000001 "Any of the renal tubules composing the mesonephros. In mammals they function as excretory structures during the early embryonic development but are later incorporated into the reproductive system. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000500", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/mesonephric+tubule"}
property_value: UBPROP:0000003 "As the pronephros regresses, the archinephric duct induces the sequential differentiation of tubules in the more caudal parts of the nephric ridge. (...) Tubules that differentiate in the middle part of the nephric ridge form a kidney called the mesonephros. This kidney functions in the embryos and larvae of all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000500", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.639", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000084
name: ureteric bud
namespace: uberon
def: "An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP]." [MP:0010979, PMID:19828308]
subset: pheno_slim
synonym: "diverticulum" RELATED [BTO:0001646]
synonym: "diverticulum metanephricum" RELATED OMO:0003011 [Wikipedia:Ureteric_bud]
synonym: "gemma ureterica" RELATED OMO:0003011 [Wikipedia:Ureteric_bud]
synonym: "metanephric bud" RELATED [BTO:0001646]
synonym: "metanephric diverticulum" RELATED [Wikipedia:Metanephros#Metanephros]
synonym: "ureteric ampulla" RELATED []
synonym: "ureteric diverticulum" RELATED [VHOG:0000541]
xref: BTO:0001646
xref: EHDAA2:0002140
xref: EHDAA:3091
xref: EHDAA:5917
xref: EMAPA:17209
xref: NCIT:C34207
xref: SCTID:361528000
xref: UMLS:C1284058 {source="ncithesaurus:Metanephric_Diverticulum"}
xref: VHOG:0000541
xref: Wikipedia:Ureteric_bud
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
is_a: UBERON:0034969 ! epithelial layer of duct
relationship: developmentally_induced_by UBERON:0003220 {source="ISBN:9780878932504"} ! metanephric mesenchyme
relationship: develops_from UBERON:0003074 {source="EHDAA2"} ! mesonephric duct
relationship: part_of UBERON:0003074 ! mesonephric duct
property_value: UBPROP:0000001 "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts. [Embryology, See_Dudek_RW_and_Fix_JD, Third_Edition_(2004)_Philadelphia:_Lippincott_William_and_Wilkins, p.137][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000541", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000001 "Outgrowth of the mesonephric duct that penetrates the metanephric mesoderm and forms the ureter, renal pelvis, major and minor calyces and collecting ducts[VHOG:0000541]." xsd:string {source="VHOG:0000541"}
property_value: UBPROP:0000003 "The first embryonic hint of a metanephros is the formation of the metanephric duct that appears as a ureteric diverticulum arising at the base of preexisting mesonephric duct. The ureteric diverticulum grows dorsally into the posterior region of the nephric ridge. Here it enlarges and stimulates the growth of metanephric tubules that come to make up the metanephric kidney. The metanephros becomes the adult kidney of amniotes, and the metanephric duct is usually called the ureter.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000541", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.543", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000085
name: morula
namespace: uberon
def: "A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum." [MP:0012130]
subset: pheno_slim
synonym: "morula (2-16 cells)" RELATED [EHDAA2:0000005]
xref: BTO:0001508
xref: EHDAA2:0000005
xref: FMA:292334
xref: GAID:1295
xref: MESH:D009028
xref: NCIT:C34212
xref: SCTID:361474003
xref: UMLS:C0026573 {source="ncithesaurus:Morula"}
xref: Wikipedia:Morula
is_a: UBERON:0000922 ! embryo
relationship: existence_ends_during UBERON:0000107 ! cleavage stage
relationship: existence_starts_during UBERON:0000107 ! cleavage stage
relationship: has_part CL:0000353 ! blastoderm cell
relationship: part_of UBERON:0004716 {source="EHDAA2"} ! conceptus
relationship: surrounded_by UBERON:0000086 ! zona pellucida
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: UBPROP:0000012 "EHDAA2 has embryo starting later" xsd:string {external_ontology="EHDAA2"}

[Term]
id: UBERON:0000086
name: zona pellucida
namespace: uberon
def: "A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes." [Wikipedia:Zona_pellucida]
subset: human_reference_atlas
subset: pheno_slim
subset: vertebrate_core
synonym: "oolemma" RELATED [BTO:0003135]
synonym: "pellucid zone" RELATED [BTO:0003135]
synonym: "striated membrane" RELATED [BTO:0003135]
synonym: "vitelline envelope" RELATED []
synonym: "vitelline membrane" RELATED []
synonym: "zona pellucida - vitelline membrane" BROAD [VHOG:0000720]
synonym: "zona radiata" RELATED [BTO:0003135]
synonym: "zona striata" RELATED [BTO:0003135]
xref: BTO:0003135
xref: EHDAA2:0002220
xref: EHDAA:31
xref: EHDAA:62
xref: EMAPA:16035
xref: FMA:18674
xref: GAID:410
xref: MA:0001715
xref: MESH:D015044
xref: NCIT:C33896
xref: TAO:0001111
xref: UMLS:C0043519 {source="ncithesaurus:Zona_Pellucida"}
xref: VHOG:0000720
xref: Wikipedia:Zona_pellucida
xref: ZFA:0001111
is_a: UBERON:0005764 ! acellular membrane
relationship: bounding_layer_of CL:0000023 ! oocyte
relationship: has_part CHEBI:17089 ! glycoprotein
relationship: part_of CL:0000023 ! oocyte
relationship: part_of UBERON:0000992 ! ovary
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/8/81/Gray3.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "Outside the plasma membrane, three envelopes surround the ovum. The first, the primary egg envelope, lies between the plasma membrane and the surrounding cells of the ovary. The most consistent component of this primary layer is the vitelline membrane, a transparent jacket of fibrous protein. In mammals, the homologous structure is called the zona pellucida.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000720", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.159", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000087
name: inner cell mass
namespace: uberon
def: "A mass of cells that develop into the body of the embryo and some extraembryonic tissues." [ISBN:0-683-40008-8, MGI:pvb]
subset: early_development
subset: efo_slim
subset: pheno_slim
synonym: "early embryoblast" RELATED [FMA:86557]
synonym: "embryoblast" RELATED []
synonym: "embryoblastus; massa cellularis interna; pluriblastus senior" RELATED OMO:0003011 [Wikipedia:Inner_cell_mass]
synonym: "ICM" RELATED [VHOG:0000742]
synonym: "pluriblast" RELATED []
xref: EFO:0000547
xref: EHDAA2:0000830
xref: EHDAA:40
xref: EMAPA:16041
xref: FMA:86557
xref: NCIT:C13740
xref: SCTID:361456007
xref: UMLS:C1283994 {source="ncithesaurus:Inner_Cell_Mass"}
xref: VHOG:0000742
xref: Wikipedia:Inner_cell_mass
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000358 {source="Wikipedia"} ! blastocyst
relationship: surrounded_by UBERON:0000088 {source="Wikipedia"} ! trophoblast
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: UBPROP:0000001 "A group of cells found in the mammalian blastocyst that give rise to the embryo. [Biology_Online][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000003 "A small sphere of cells known as the inner cell mass lies within the trophoblast (of all eutherian mammals).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000742", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.144", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "This structure forms in the earliest steps of development, before implantation into the endometrium of the uterus has occurred.The ICM lies within the blastocyst cavity and is entirely surrounded by the single layer of cells called trophoblast. [Wikipedia:Inner_cell_mass]" xsd:string

[Term]
id: UBERON:0000088
name: trophoblast
namespace: uberon
def: "The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta." [ISBN:0-683-40008-8, MP:0005031]
comment: Aggregate of cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. [Wikipedia:Trophoblast]
subset: early_development
subset: pheno_slim
synonym: "massa cellularis externa" RELATED OMO:0003011 [Wikipedia:Trophoblast]
synonym: "trophoblast layer" EXACT [MP:0005031]
synonym: "trophoblastus" RELATED OMO:0003011 [Wikipedia:Trophoblast]
synonym: "trophoderm" RELATED [BTO:0001079]
xref: BTO:0001079
xref: CALOHA:TS-1070
xref: EV:0100120
xref: FMA:83029
xref: GAID:1152
xref: MESH:D014327
xref: NCIT:C93292
xref: SCTID:362839005
xref: UMLS:C0041178 {source="ncithesaurus:Trophoblast"}
xref: Wikipedia:Trophoblast
is_a: UBERON:0002050 ! embryonic structure
relationship: composed_primarily_of CL:0000351 ! trophoblast cell
relationship: develops_from UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! trophectoderm
relationship: part_of UBERON:0000358 ! blastocyst
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: UBPROP:0000001 "the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta[MP]" xsd:string {date_retrieved="2012-08-23", external_class="MP:0005031", external_class_label="trophoblast layer", ontology="MP", source="ISBN:0-683-40008-8"}
property_value: UBPROP:0000007 "trophoblastic" xsd:string
property_value: UBPROP:0000011 "The postimplantation derivatives of the trophectoderm, which make up most of the fetal part of the placenta" xsd:string {source="PMID:19829370"}

[Term]
id: UBERON:0000091
name: bilaminar disc
namespace: uberon
def: "A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc." [MP:0003886]
subset: early_development
subset: pheno_slim
synonym: "bilaminar disk" RELATED [Wikipedia:Bilaminar_disc]
synonym: "bilaminary embryonic disc" EXACT []
synonym: "bilaminary germ disc" EXACT [ISBN:9780878932504]
synonym: "embryonic disc" BROAD [MP:0003886]
synonym: "embryonic shield" BROAD [MP:0003886]
synonym: "germinal disc" BROAD [MP:0003886]
synonym: "germinal disk" BROAD [MP:0003886]
xref: FMA:293863
xref: NCIT:C34112
xref: UMLS:C1283997 {source="ncithesaurus:Bilaminar_Embryonic_Disc"}
xref: Wikipedia:Bilaminar_disc
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000087 {source="Wikipedia"} ! inner cell mass
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI

[Term]
id: UBERON:0000092
name: post-embryonic stage
namespace: uberon
def: "Stage succeeding embryo, including mature structure." [https://orcid.org/0000-0002-6601-2165]
synonym: "post-hatching stage" NARROW []
synonym: "postembryonic" RELATED []
synonym: "postembryonic stage" EXACT []
xref: BilaDO:0000003
xref: OGES:000010
xref: OGES:000014
xref: OGES:000024
xref: WBls:0000022
xref: WBls:0000093
xref: WBls:0000103
is_a: UBERON:0000105 ! life cycle stage
relationship: preceded_by UBERON:0000068 ! embryo stage
relationship: simultaneous_with GO:0009791 ! post-embryonic development
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/344" xsd:anyURI
property_value: UBPROP:0000008 "In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997)" xsd:string

[Term]
id: UBERON:0000094
name: membrane organ
namespace: uberon
def: "Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]." [FMA:7145]
synonym: "membrane" BROAD []
synonym: "membrane of organ" EXACT []
xref: FMA:7145
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000062 ! organ
relationship: composed_primarily_of UBERON:0011823 {source="FMA-def"} ! dense connective tissue
property_value: term:contributor https://orcid.org/0000-0002-6601-2165
creation_date: 2009-07-30T05:19:13Z

[Term]
id: UBERON:0000095
name: cardiac neural crest
namespace: uberon
def: "Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]." [Wikipedia:Cardiac_neural_crest]
subset: vertebrate_core
synonym: "cardiac neural crest complex" RELATED [Wikipedia:Cardiac_neural_crest]
synonym: "complexus cristae neuralis cardiacus" RELATED [Wikipedia:Cardiac_neural_crest]
xref: TAO:0002173
xref: Wikipedia:Cardiac_neural_crest
xref: XAO:0004190
xref: ZFA:0001648
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: overlaps UBERON:0005428 {source="Wikipedia"} ! vagal neural crest
relationship: part_of UBERON:0002342 ! neural crest
property_value: term:contributor https://orcid.org/0000-0002-6601-2165
property_value: UBPROP:0000001 "A subpopulation of the cephalic neural crest that emerges from the otic level to the anterior limit of somite 4. It migrates to the heart and is essential for the septation of the outflow track[DOI:10.1242/dev.091751]." xsd:string {source="DOI:10.1242/dev.091751"}
property_value: UBPROP:0000012 "ZFA treats this as a subtype of NC." xsd:string {external_ontology="ZFA"}
creation_date: 2009-07-30T07:57:38Z

[Term]
id: UBERON:0000101
name: lobe of lung
namespace: uberon
def: "A lung lobe is one of the rounded projections that compose the lung[GO]." [GOC:GO]
subset: pheno_slim
synonym: "lung lobe" EXACT []
synonym: "pulminory lobe" EXACT []
synonym: "pulmonary lobe" EXACT [FMA:7311]
xref: EMAPA:36281
xref: FMA:7311
xref: galen:LobeOfLung
xref: MA:0003098
xref: NCIT:C34021
xref: SCTID:245524004
xref: UMLS:C0225752 {source="ncithesaurus:Lung_Lobe"}
is_a: UBERON:0004119 ! endoderm-derived structure
is_a: UBERON:0009912 {source="FMA"} ! anatomical lobe
relationship: contributes_to_morphology_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0000102
name: lung vasculature
namespace: uberon
def: "The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]." [GOC:GO]
subset: pheno_slim
synonym: "lung vascular network" EXACT [OBOL:automatic]
synonym: "pulmonary vasculature" EXACT [FMA:73750]
synonym: "vascular network of lung" EXACT [OBOL:automatic]
synonym: "vasculature of lung" EXACT [OBOL:automatic]
xref: FMA:73750
is_a: UBERON:0002201 ! vasculature of trunk
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0002048 ! lung
relationship: part_of UBERON:0002048 ! lung

[Term]
id: UBERON:0000104
name: life cycle
namespace: uberon
def: "An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism." [https://orcid.org/0000-0002-6601-2165]
subset: common_anatomy
subset: upper_level
synonym: "entire life cycle" EXACT []
synonym: "entire lifespan" EXACT []
synonym: "life" EXACT []
synonym: "lifespan" EXACT []
xref: FBdv:00000000
xref: HsapDv:0000001
xref: MmusDv:0000001
xref: ncithesaurus:Life
xref: OGES:000011
is_a: UBERON:0000000 ! processual entity
relationship: ends_with UBERON:0000071 ! death stage
relationship: has_part UBERON:0000105 ! life cycle stage
relationship: starts_with UBERON:0000106 {gci_relation="in_taxon", gci_filler="NCBITaxon:33208"} ! zygote stage
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/532" xsd:anyURI

[Term]
id: UBERON:0000105
name: life cycle stage
namespace: uberon
def: "A spatiotemporal region encompassing some part of the life cycle of an organism." [https://orcid.org/0000-0002-6601-2165]
subset: common_anatomy
subset: efo_slim
subset: upper_level
synonym: "developmental stage" NARROW []
synonym: "stage" NARROW []
xref: BILS:0000105
xref: EFO:0000399
xref: FBdv:00007012
xref: FMA:24120
xref: HsapDv:0000000
xref: MESH:D008018
xref: MmusDv:0000000
xref: ncithesaurus:Developmental_Stage
xref: OlatDv:0000010
xref: PdumDv:0000090
xref: WBls:0000002
xref: XAO:1000000
xref: ZFS:0000000
xref: ZFS:0100000
is_a: UBERON:0000000 ! processual entity
relationship: part_of UBERON:0000104 ! life cycle
property_value: editor_note "this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here" xsd:string
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: UBPROP:0000012 "the WBls class 'all stages' belongs here as it is the superclass of other WBls stages" xsd:string
property_value: UBPROP:0000012 "we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage" xsd:string

[Term]
id: UBERON:0000106
name: zygote stage
namespace: uberon
def: "A stage at which the organism is a single cell produced by means of sexual reproduction." [Wikipedia:Zygote]
subset: efo_slim
synonym: "1-cell stage" EXACT []
synonym: "fertilized egg stage" EXACT [BTO:0000854]
synonym: "fertilized egg stage" RELATED []
synonym: "one cell stage" EXACT []
synonym: "one-cell stage" RELATED [VHOG:0000745]
synonym: "zygote" RELATED [VHOG:0000745]
synonym: "zygotum" RELATED OMO:0003011 [Wikipedia:Zygote]
xref: BilaDO:0000005
xref: BILS:0000106
xref: EFO:0001322
xref: EHDAA:27
xref: FBdv:00005288
xref: IDOMAL:0000302 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: NCIT:C12601
xref: PdumDv:0000100
xref: VHOG:0000745
xref: Wikipedia:Zygote
xref: XAO:1000001
xref: ZFS:0000001
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: seeAlso EMAPA:16033
relationship: starts UBERON:0000104 ! life cycle
property_value: UBPROP:0000003 "As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000745", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000107
name: cleavage stage
namespace: uberon
def: "The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula." [GO:0040016, Wikipedia:Cleavage_(embryo)]
subset: efo_slim
xref: BilaDO:0000006
xref: BILS:0000107
xref: EFO:0001290
xref: FBdv:00000054
xref: MESH:D002970
xref: MmusDv:0000004
xref: OGES:000015
xref: OGES:000020
xref: PdumDv:0000200
xref: Wikipedia:Cleavage_(embryo)
xref: XAO:1000004
xref: ZFS:0000046
is_a: UBERON:0000105 ! life cycle stage
intersection_of: UBERON:0000105 ! life cycle stage
intersection_of: simultaneous_with GO:0040016 ! embryonic cleavage
relationship: immediately_preceded_by UBERON:0000106 ! zygote stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: simultaneous_with GO:0040016 ! embryonic cleavage

[Term]
id: UBERON:0000108
name: blastula stage
namespace: uberon
def: "An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula]
subset: efo_slim
xref: BilaDO:0000007
xref: BILS:0000108
xref: EFO:0001282
xref: HsapDv:0000006
xref: MmusDv:0000007
xref: OGES:000003
xref: OGES:000016
xref: OGES:000021
xref: WBls:0000005
xref: Wikipedia:Blastula
xref: XAO:1000003
xref: ZFS:0000045
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000107 ! cleavage stage
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "consider adding a preceding stage 'morula stage' as part of cleavage" xsd:string

[Term]
id: UBERON:0000109
name: gastrula stage
namespace: uberon
def: "A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GO:0007369]
subset: efo_slim
synonym: "blastocystis trilaminaris stage" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "trilaminar blastocyst stage" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "trilaminar blastoderm stage" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "trilaminar disk stage" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "trilaminar germ stage" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "trilaminar stage" RELATED [https://orcid.org/0000-0002-6601-2165]
xref: BilaDO:0000008
xref: BILS:0000109
xref: EFO:0001296
xref: FBdv:00005317
xref: HsapDv:0000010
xref: MmusDv:0000013
xref: OGES:000004
xref: OGES:000019
xref: WBls:0000010
xref: XAO:1000005
xref: ZFS:0000047
is_a: UBERON:0000105 ! life cycle stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000108 {source="BILS"} ! blastula stage
relationship: simultaneous_with GO:0007369 ! gastrulation

[Term]
id: UBERON:0000110
name: neurula stage
namespace: uberon
def: "Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GO:0001841]
xref: BilaDO:0000009
xref: BILS:0000110
xref: HsapDv:0000012
xref: MmusDv:0000017
xref: XAO:1000006
is_a: UBERON:0000105 ! life cycle stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000109 ! gastrula stage
relationship: simultaneous_with GO:0001841 ! neural tube formation
property_value: RO:0002174 NCBITaxon:7955
property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/343" xsd:anyURI
property_value: UBPROP:0000008 "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." xsd:string

[Term]
id: UBERON:0000111
name: organogenesis stage
namespace: uberon
def: "A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism." [Wikipedia:Organogenesis]
synonym: "segmentation stage" RELATED []
xref: BilaDO:0000010
xref: BILS:0000111
xref: HsapDv:0000015
xref: MmusDv:0000018
xref: OGES:000005
xref: OGES:000032
xref: Wikipedia:Organogenesis
is_a: UBERON:0000105 ! life cycle stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000110 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! neurula stage
relationship: simultaneous_with GO:0048513 ! animal organ development
property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/533" xsd:anyURI

[Term]
id: UBERON:0000112
name: sexually immature stage
namespace: uberon
subset: efo_slim
synonym: "immature stage" EXACT [VHOG:FB]
synonym: "juvenile stage" NARROW [XAO:1000010]
synonym: "subadult stage" RELATED [http://eol.org/schema/terms/subadult]
xref: BILS:0000112
xref: BTO:0002168
xref: EFO:0001300
xref: EV:0300051
xref: MmusDv:0000043
xref: OGES:000009
xref: XAO:1000010
xref: XtroDO:0000083
xref: ZFS:0000051
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000066 ! fully formed stage
relationship: preceded_by UBERON:0000069 {gci_relation="part_of", gci_filler="NCBITaxon:7955", source="ZFS"} ! larval stage
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/427" xsd:anyURI
property_value: UBPROP:0000001 "The stage of being a sexually immature adult animal[XAO:1000010]." xsd:string {source="XAO:1000010"}
property_value: UBPROP:0000008 "In mammals this would include infant (nourishment from lactation) and juvenile (prepubertal no longer dependent on mother)" xsd:string

[Term]
id: UBERON:0000113
name: post-juvenile adult stage
namespace: uberon
def: "The stage of being a sexually mature adult animal." [https://orcid.org/0000-0002-6601-2165]
synonym: "adult stage" BROAD []
xref: BILS:0000113
xref: EV:0300064
xref: EV:0300070
xref: MIAA:0000403
xref: MmusDv:0000110
xref: OGES:000026
xref: OGES:000027
xref: XAO:1000093
xref: ZFS:0000044
is_a: UBERON:0000105 ! life cycle stage
relationship: part_of UBERON:0000066 ! fully formed stage
relationship: preceded_by UBERON:0000112 ! sexually immature stage
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/345" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/499" xsd:anyURI

[Term]
id: UBERON:0000114
name: lung connective tissue
namespace: uberon
def: "The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin." [ISBN:0-683-40008-8, MGI:anna, MP:0002276, PMID:14635660]
subset: human_reference_atlas
subset: pheno_slim
synonym: "connective tissue of lung" EXACT [OBOL:automatic]
synonym: "lung interstitial tissue" RELATED [MA:0001782]
synonym: "lung interstitium" RELATED []
synonym: "pulmonary connective tissue" RELATED [EMAPA:35521]
synonym: "pulmonary interstitial tissue" RELATED []
synonym: "pulmonary interstitium" EXACT [FMA:27533]
xref: EMAPA:35521
xref: FMA:27533
xref: MA:0001782
xref: SCTID:201609008
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
is_a: UBERON:0003580 ! lower respiratory tract connective tissue
is_a: UBERON:0003837 ! thoracic segment connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002048 ! lung
relationship: contributes_to_morphology_of UBERON:0002048 ! lung
relationship: develops_from UBERON:0004883 ! lung mesenchyme
relationship: part_of UBERON:0002048 ! lung
relationship: transformation_of UBERON:0004883 ! lung mesenchyme
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000009 "it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces" xsd:string

[Term]
id: UBERON:0000115
name: lung epithelium
namespace: uberon
def: "The epithelial layer of the lung." [MP:0006382]
subset: pheno_slim
synonym: "epithelial tissue of lung" EXACT [OBOL:automatic]
synonym: "epithelium of lung" EXACT [OBOL:automatic]
synonym: "lung epithelial tissue" EXACT [OBOL:automatic]
synonym: "pulmonary epithelium" RELATED [BTO:0001653]
xref: BTO:0001653
xref: EMAPA:32860
xref: MA:0001783
is_a: UBERON:0004815 ! lower respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002048 ! lung
relationship: contributes_to_morphology_of UBERON:0002048 ! lung
relationship: develops_from UBERON:0001041 ! foregut
relationship: part_of UBERON:0002048 ! lung
property_value: UBPROP:0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" xsd:string

[Term]
id: UBERON:0000117
name: respiratory tube
namespace: uberon
def: "A tube in the respiratory system. Examples: bronchus, bronchiole, trachea." [GO:0030323, http://orcid.org/0000-0002-6601-2165]
synonym: "airway" RELATED []
synonym: "respiratory conducting tube" NARROW [MP:0004391]
synonym: "segment of tracheobronchial tree" EXACT [FMA:12224]
synonym: "segment of tracheobronchial tree" NARROW [FMA:12224]
synonym: "tracheobronchial tree segment" NARROW [FMA:12224]
xref: EMAPA:37946 {source="MA:th"}
xref: FMA:12224
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000025 ! tube
is_a: UBERON:0004119 ! endoderm-derived structure
intersection_of: UBERON:0000025 ! tube
intersection_of: part_of UBERON:0000065 ! respiratory tract
relationship: has_part UBERON:0000483 ! epithelium
relationship: part_of UBERON:0000065 ! respiratory tract
property_value: UBPROP:0000012 "in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class)" xsd:string {external_ontology="GO"}

[Term]
id: UBERON:0000118
name: lung bud
namespace: uberon
def: "Structure derived from foregut that becomes a lung[GO]." [GO:0060431, Wikipedia:Respiratory_bud]
subset: pheno_slim
synonym: "gemma pulmonalis" RELATED OMO:0003011 [Wikipedia:Lung_buds]
synonym: "gemma respiratoria" RELATED OMO:0003011 [Wikipedia:Lung_buds]
synonym: "lung bud" RELATED OMO:0003004 []
synonym: "primary lung bud" RELATED [GO:0060572]
synonym: "respiratory diverticulum" RELATED [Wikipedia:Lung_buds]
xref: BTO:0001643
xref: EHDAA2:0004089
xref: NCIT:C34260
xref: NCIT:C34282
xref: SCTID:361427007
xref: UMLS:C1514420 {source="ncithesaurus:Primary_Bronchial_Bud"}
xref: UMLS:C1514897 {source="ncithesaurus:Respiratory_Diverticulum"}
xref: Wikipedia:Respiratory_bud
is_a: UBERON:0005153 {source="GO:0060441"} ! epithelial bud
is_a: UBERON:0005911 ! endo-epithelium
relationship: adjacent_to UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: develops_from UBERON:0005597 ! lung primordium
relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/7/71/Gray948.png" xsd:anyURI
property_value: editor_note "clarify successors - include bronchi?" xsd:string

[Term]
id: UBERON:0000122
name: neuron projection bundle
namespace: uberon
alt_id: UBERON:0005163
def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." [CARO:0001001, FBbt:00005099, FBC:DOS]
synonym: "funiculus" EXACT []
synonym: "nerve fiber bundle" EXACT [FBbt:00005099]
synonym: "neural fiber bundle" EXACT []
xref: CARO:0001001
xref: FBbt:00005099 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: NLX:147821
is_a: UBERON:0005162 ! multi cell part structure
relationship: has_part GO:0043005 ! neuron projection
relationship: part_of UBERON:0001016 ! nervous system

[Term]
id: UBERON:0000125
name: neural nucleus
namespace: uberon
def: "A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)." [NLX:28443]
subset: cumbo
synonym: "nervous system nucleus" EXACT []
synonym: "neuraxis nucleus" EXACT [FMA:83686]
synonym: "neuronal nucleus" EXACT [AEO:0000136]
synonym: "nucleus" BROAD []
synonym: "nucleus of CNS" EXACT [NLX:28443]
synonym: "nucleus of neuraxis" RELATED []
xref: AEO:0000136
xref: FMA:83686
xref: NCIT:C13197
xref: NLX:28443
xref: Wikipedia:Nucleus_(neuroanatomy)
is_a: UBERON:0011215 ! central nervous system cell part cluster
relationship: composed_primarily_of UBERON:0002020 ! gray matter
relationship: only_in_taxon NCBITaxon:7711 {notes="we limit this structure by definition to chordate and vertebrate nervous systems"} ! Chordata
property_value: UBPROP:0000001 "Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]." xsd:string {source="GO_REF:0000021"}
property_value: UBPROP:0000012 "Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate." xsd:string

[Term]
id: UBERON:0000126
name: cranial nerve nucleus
namespace: uberon
def: "Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves." [NLX:28532]
synonym: "cranial neural nucleus" EXACT [FMA:54501]
synonym: "nucleus nervi cranialis" RELATED OMO:0003011 [Wikipedia:Cranial_nerve_nucleus]
synonym: "nucleus of cranial nerve" EXACT []
xref: EMAPA:37066 {source="MA:th"}
xref: FMA:54501
xref: NLX:28532
xref: SCTID:280160003
xref: Wikipedia:Cranial_nerve_nucleus
is_a: UBERON:0002308 ! nucleus of brain
intersection_of: UBERON:0002308 ! nucleus of brain
intersection_of: extends_fibers_into UBERON:0001785 ! cranial nerve
relationship: extends_fibers_into UBERON:0001785 ! cranial nerve
relationship: part_of RO:0002577 ! system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/3/30/Gray696.png" xsd:anyURI

[Term]
id: UBERON:0000153
name: anterior region of body
namespace: uberon
is_a: UBERON:0000475 ! organism subdivision
disjoint_from: UBERON:0000154 {source="lexical"} ! posterior region of body
relationship: anterior_to UBERON:0000154 ! posterior region of body
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria

[Term]
id: UBERON:0000154
name: posterior region of body
namespace: uberon
is_a: UBERON:0000475 ! organism subdivision
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria

[Term]
id: UBERON:0000158
name: membranous layer
namespace: uberon
synonym: "membrane" BROAD []
synonym: "membranous organ component" EXACT [FMA:82500]
xref: FMA:30322
xref: FMA:82500
xref: MESH:D008566
xref: NCIT:C12749
is_a: UBERON:0004923 ! organ component layer
relationship: bounding_layer_of UBERON:0000064 ! organ part
property_value: UBPROP:0000001 "A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures." xsd:string {source="ncithesaurus:Membrane"}

[Term]
id: UBERON:0000159
name: anal canal
namespace: uberon
def: "The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus." [Wikipedia:Anal_canal]
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "anal canal" EXACT []
synonym: "anal canal viewed anatomically" EXACT []
synonym: "anal pad" RELATED []
synonym: "anatomical anal canal" EXACT []
synonym: "anus" RELATED []
synonym: "canalis analis" RELATED OMO:0003011 [BTO:0001978, Wikipedia:Anal_canal]
synonym: "cloaca" RELATED []
synonym: "cloacal chamber" RELATED []
synonym: "mesenteron" RELATED []
synonym: "pars analis recti" RELATED [BTO:0001978]
xref: BTO:0001978
xref: CALOHA:TS-2160
xref: EMAPA:18256
xref: FMA:15703
xref: galen:AnalCanal
xref: MA:0000330
xref: MESH:D001003 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0001-9439-5346", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: NCIT:C12375
xref: SCTID:245438008
xref: UMLS:C0227411 {source="ncithesaurus:Anal_Canal"}
xref: Wikipedia:Anal_canal
is_a: UBERON:0004111 ! anatomical conduit
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: channel_for UBERON:0001988 ! feces
relationship: continuous_with UBERON:0001052 ! rectum
relationship: continuous_with UBERON:0001245 ! anus
relationship: develops_from UBERON:0011272 {source="Wikipathways:WP2062"} ! embryonic skin basal layer
relationship: part_of UBERON:0000059 ! large intestine
relationship: part_of UBERON:0001353 ! anal region
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/0/01/Gray1078.png" xsd:anyURI
property_value: editor_note "requires alignment with EHDAA2 and complete developmental relationships" xsd:string
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000160
name: intestine
namespace: uberon
def: "Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine." [GOC:GO, Wikipedia:Intestine]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "bowel" EXACT []
synonym: "intestinal tract" RELATED []
xref: AAO:0000246
xref: ANISEED:1235303
xref: BSA:0000093
xref: BTO:0000648
xref: CALOHA:TS-0490
xref: EFO:0000834
xref: EMAPA:32874
xref: EV:0100071
xref: FMA:7199
xref: GAID:295
xref: galen:Intestine
xref: MA:0000328
xref: MA:0001524
xref: MESH:D007422
xref: MIAA:0000043
xref: NCIT:C12736
xref: SCTID:256876008
xref: TAO:0001338
xref: UMLS:C0021853 {source="ncithesaurus:Intestine"}
xref: VHOG:0000056
xref: WBbt:0005772
xref: Wikipedia:Intestine
xref: XAO:0000129
xref: ZFA:0001338
is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract
relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
property_value: editor_note "This class is probably too inclusive" xsd:string
property_value: UBPROP:0000001 "Portion of the alimentary canal bounded anteriorly by the pyloric sphincter and posteriorly by the cloacal sphincter.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000246", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The tract of the alimentary canal. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000056", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "intestinal" xsd:string
property_value: UBPROP:0000008 "In zebrafish, No stomach, small intestine, or large intestine can be distinguished. However, differences can be found in the morphology of the mucosa columnar epithelial cells and the number of goblet cells, suggesting functional differentiation. The intestine has numerous folds that become progressively shorter in a rostral-to-caudal direction. Proportionally, these folds are significantly larger than the finger-like intestinal villi of mammals and other amniotes (Wallace et al. 2005). Columnar-shaped absorptive enterocytes are the most numerous in the zebrafish intestinal epithelium. Goblet cells are the second most populous epithelial cell type." xsd:string

[Term]
id: UBERON:0000161
name: orifice
namespace: uberon
def: "Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]." [FMA:3724]
synonym: "anatomical orifice" EXACT [FMA:3724]
synonym: "anatomical ostium" BROAD [FMA:3724]
synonym: "hilum" NARROW []
synonym: "ostium" BROAD []
xref: FMA:3724
xref: SCTID:91837002
is_a: UBERON:0004111 ! anatomical conduit
property_value: UBPROP:0000012 "in FMA, this is an anatomical conduit *space*, rather than anatomical conduit" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000162
name: cloaca
namespace: uberon
def: "Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures." [ISBN:0073040584, Wikipedia:Cloaca]
synonym: "cloacal chamber" RELATED [AAO:0000095]
synonym: "vent" RELATED [XAO:0000244]
xref: AAO:0000095
xref: GAID:1206
xref: MESH:D002988
xref: NCIT:C34127
xref: SCTID:362857006
xref: SCTID:370631000
xref: UMLS:C0008987 {source="ncithesaurus:Cloaca"}
xref: VHOG:0001186
xref: Wikipedia:Cloaca
xref: XAO:0000244
xref: ZFA:0005781
is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0001555 {source="ZFA"} ! digestive tract
relationship: part_of UBERON:0004122 {source="AAO"} ! genitourinary system
property_value: editor_note "adding df link to embryonic cloaca leads to a cycle in uberon-simple, as cloaca is a suberclass of embryonic cloaca" xsd:string
property_value: RO:0002175 NCBITaxon:9369 {notes="most adult placentals have no trace of a cloaca. However, the tenrecs and golden moles, small placental mammals native to Africa, retain a cloaca as adults."}
property_value: UBPROP:0000001 "A common passage for fecal, urinary, and reproductive discharge in most lower vertebrates as well as the terminal end of the hindgut before division into rectum, bladder, and genital primordia in mammalian embryos. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001186", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/cloaca"}
property_value: UBPROP:0000001 "Anatomical structure which is the common receptacle for the alimentary canal, Wolffian ducts, oviducts, and the bladder.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000095", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "A cloaca is apparently a primitive vertebrate feature because it occurs in most primitive gnathostomes and persists in the embryos of almost all vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001186", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.572", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "cloacal" xsd:string
property_value: UBPROP:0000008 "Human beings only have an embryonic cloaca, which is split up into separate tracts during the development of the urinary and reproductive organs" xsd:string
property_value: UBPROP:0000011 "hindgut endoderm and proctodeal ectoderm." xsd:string {source="WP"}

[Term]
id: UBERON:0000163
name: embryonic cloaca
namespace: uberon
def: "Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]." [MP:0010115, Wikipedia:Cloaca_(embryology)]
subset: pheno_slim
synonym: "cloaca" RELATED SENSU []
xref: EHDAA2:0000256
xref: EHDAA:4895
xref: EMAPA:27573
xref: Wikipedia:Cloaca_(embryology)
is_a: UBERON:0000162 ! cloaca
relationship: has_developmental_contribution_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0000922 ! embryo
relationship: part_of UBERON:0001008 {source="EHDAA2"} ! renal system
relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region
property_value: curator_notes "this class represents the embryonic form of the cloaca, as found in both mammals and non-mammals." xsd:string

[Term]
id: UBERON:0000164
name: primitive urogenital sinus
namespace: uberon
def: "The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females." [ISBN:0-683-40008-8, MP:0010116]
subset: pheno_slim
synonym: "fetal UGS" EXACT [PMID:18977204]
synonym: "sinus urogenitalis" EXACT OMO:0003011 []
synonym: "UGS" EXACT [MP:0010116]
synonym: "urogenital sinus" BROAD [MP:0010116]
xref: EHDAA2:0004060
xref: EHDAA:5029
xref: EHDAA:5919
xref: EMAPA:17379
xref: NCIT:C34322
xref: SCTID:50961009
xref: UMLS:C0231057 {source="ncithesaurus:Urogenital_Sinus"}
xref: VHOG:0000414
xref: Wikipedia:Definitive_urogenital_sinus
is_a: UBERON:0002050 ! embryonic structure
relationship: contributes_to_morphology_of UBERON:0000163 ! embryonic cloaca
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0000163 {source="MP-def"} ! embryonic cloaca
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png" xsd:anyURI
property_value: UBPROP:0000001 "The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000414", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/urogenital+sinus"}
property_value: UBPROP:0000003 "In mammals the lowly monotremes still have a cloaca. Higher types have done away with this structure and have a separate anal outlet for the rectum. The monotreme cloaca shows the initiation of this subdivision. The cloaca has such includes only the distal part, roughly comparable to the proctodeum. The more proximal part is divided into (1) a large dorsal passage into which the intestine opens, the coprodeum, and (2) a ventral portion, the urodeum with which the bladder connects. (...) the development of the placental mammals recapitulates in many respects the phylogenetic story. In the sexually indifferent stage of placental mammal there is a cloaca. While the indifferent stage still persists, a septum develops, and extends out to the closing membrane. This divides the cloaca into two chambers: a coprodeum continuous with the gut above, and a urodeum or urogenital sinus below.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000414", ontology="VHOG", source="ISBN:978-0721676678 Romer AS, Vertebrate body (1970)p.388-89 and Figure 300", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000013 "the term 'urogenital sinus' may refer to the primitive urogenital sinus present as a transient developmental structure in most mammals or it may refer to a condition in which an unseptated cloaca persists in animals longer than normal" xsd:string {source="MP"}

[Term]
id: UBERON:0000165
name: mouth
namespace: uberon
def: "The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, Wikipedia:Mouth]
subset: efo_slim
subset: major_organ
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "adult mouth" NARROW []
synonym: "cavital oralis" RELATED OMO:0003011 [Wikipedia:Mouth]
synonym: "cavitas oris" RELATED [BTO:0001090]
synonym: "cavum oris" RELATED [BTO:0001090]
synonym: "mouth cavity" RELATED [BTO:0001090]
synonym: "oral region" RELATED [EHDAA2:0001326]
synonym: "oral vestibule" RELATED [BTO:0001090]
synonym: "regio oralis" EXACT OMO:0003011 [BTO:0004698, FMA:49184, FMA:TA]
synonym: "rima oris" RELATED [BTO:0001090]
synonym: "stoma" RELATED []
synonym: "stomatodaeum" RELATED [VHOG:0000812]
synonym: "trophic apparatus" RELATED [http://orcid.org/0000-0002-6601-2165]
synonym: "vestibule of mouth" RELATED [BTO:0001090]
synonym: "vestibulum oris" RELATED [BTO:0001090]
xref: AAO:0010355
xref: BTO:0001090
xref: BTO:0004698
xref: CALOHA:TS-1315
xref: EFO:0000825
xref: EHDAA2:0001326
xref: EHDAA:542
xref: EMAPA:16262
xref: FBbt:00003126 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:49184
xref: GAID:75
xref: galen:Mouth
xref: http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg
xref: MA:0000341
xref: MA:0002474
xref: MAT:0000038
xref: MESH:D009055
xref: MIAA:0000038
xref: SCTID:21082005
xref: TADS:0000040
xref: TAO:0000547
xref: TAO:0000590
xref: TGMA:0000131
xref: VHOG:0000280
xref: VHOG:0000812
xref: Wikipedia:Mouth
xref: XAO:0003029
xref: ZFA:0000547
xref: ZFA:0000590
is_a: UBERON:0004921 {notes="the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts"} ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: proximalmost_part_of UBERON:0001555 ! digestive tract
relationship: develops_from UBERON:0035804 ! future mouth
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: proximalmost_part_of UBERON:0001555 ! digestive tract
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/661" xsd:anyURI
property_value: UBPROP:0000001 "Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010355", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000812", ontology="VHOG", source="DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "oral" xsd:string
property_value: UBPROP:0000011 "some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives" xsd:string
property_value: UBPROP:0000012 "in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000166
name: oral opening
namespace: uberon
def: "The orifice that connects the mouth to the exterior of the body." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract]
subset: uberon_slim
subset: vertebrate_core
synonym: "mouth" RELATED INCONSISTENT []
synonym: "oral fissure" EXACT [FMA:59806]
synonym: "oral orifice" EXACT [FMA:59806]
synonym: "oral part of face" RELATED []
xref: FMA:59806
is_a: UBERON:0000161 {source="FMA"} ! orifice
relationship: overlaps UBERON:0001004 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! respiratory system
relationship: part_of UBERON:0000165 ! mouth
property_value: UBPROP:0000003 "(...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000280", ontology="VHOG", source="DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007)", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000167
name: oral cavity
namespace: uberon
def: "Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present)." [https://github.com/obophenotype/uberon/wiki/The-digestive-tract, https://orcid.org/0000-0002-6601-2165, ISBN:0073040584]
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "bucca" RELATED []
synonym: "buccal cavity" EXACT [FMA:20292, ISBN:0073040584]
synonym: "cavity of mouth" EXACT []
xref: AAO:0000053
xref: AAO:0000960
xref: BSA:0000107
xref: CALOHA:TS-1315
xref: EFO:0001975
xref: EHDAA2:0001324
xref: EHDAA:6970
xref: EMAPA:17411
xref: EMAPA:18399
xref: EV:0100057
xref: FMA:20292
xref: HAO:0000669
xref: MESH:D009055 {sssom:mapping_provider="https://github.com/biopragmatics/biomappings", sssom:mapping_justification="vocab:LexicalMatching"}
xref: NCIT:C12421
xref: SCTID:181220002
xref: TAO:0001027
xref: TGMA:0000102
xref: UMLS:C0226896 {source="ncithesaurus:Oral_Cavity"}
xref: VHOG:0000188
xref: WBbt:0005255
xref: XAO:0000126
xref: ZFA:0001027
is_a: UBERON:0002553 ! anatomical cavity
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0000165 ! mouth
relationship: contributes_to_morphology_of UBERON:0000165 ! mouth
relationship: luminal_space_of UBERON:0000165 ! mouth
relationship: part_of UBERON:0000165 ! mouth
property_value: UBPROP:0000001 "Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000960", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000188", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/oral+cavity"}
property_value: UBPROP:0000003 "Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000188", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.32", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000168
name: proximal-distal subdivision of colon
namespace: uberon
def: "A section dividing a colon along a proximal-distal axis." [http://orcid.org/0000-0002-6601-2165]
subset: non_informative
synonym: "segment of colon" RELATED [FMA:222905]
xref: FMA:222905
is_a: UBERON:0004921 {order="4", source="cjm"} ! subdivision of digestive tract
intersection_of: UBERON:0013522 ! subdivision of tube
intersection_of: subdivision_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
relationship: subdivision_of UBERON:0001155 ! colon

[Term]
id: UBERON:0000170
name: pair of lungs
namespace: uberon
def: "The pair of anatomical structures comprised of a left lung and right lung." [http://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
subset: pheno_slim
synonym: "lungs" EXACT []
synonym: "lungs pair" EXACT []
synonym: "pulmones" EXACT OMO:0003011 [FMA:68877, FMA:TA]
synonym: "set of lungs" EXACT []
xref: FMA:68877
is_a: UBERON:0034925 ! anatomical collection
intersection_of: UBERON:0034925 ! anatomical collection
intersection_of: has_member UBERON:0002167 ! right lung
intersection_of: has_member UBERON:0002168 ! left lung
relationship: has_member UBERON:0002167 ! right lung
relationship: has_member UBERON:0002167 {cardinality="1"} ! right lung
relationship: has_member UBERON:0002168 ! left lung
relationship: has_member UBERON:0002168 {cardinality="1"} ! left lung
relationship: located_in UBERON:0002224 ! thoracic cavity
relationship: part_of UBERON:0001558 {source="FMA-abduced"} ! lower respiratory tract
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000171
name: respiration organ
namespace: uberon
def: "Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [GO:0007585]
subset: functional_classification
subset: organ_slim
synonym: "apparatus respiratorius organ" EXACT [OBOL:automatic]
synonym: "breathing organ" EXACT []
synonym: "gas exchange organ" RELATED []
synonym: "organ of apparatus respiratorius" EXACT [OBOL:automatic]
synonym: "organ of respiratory system" EXACT [OBOL:automatic]
synonym: "respiratory organ" EXACT []
synonym: "respiratory system organ" EXACT [OBOL:automatic]
xref: EMAPA:17607
xref: SCTID:272626006
xref: SPD:0000428
xref: TGMA:0001247
is_a: UBERON:0000062 ! organ
intersection_of: UBERON:0000062 ! organ
intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: part_of UBERON:0001004 ! respiratory system

[Term]
id: UBERON:0000174
name: excreta
namespace: uberon
alt_id: UBERON:0000324
alt_id: UBERON:0007550
def: "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity." [GO:0007588, http://orcid.org/0000-0002-6601-2165]
synonym: "excreted substance" EXACT []
synonym: "excretion" RELATED [BTO:0000491]
synonym: "portion of excreted substance" EXACT [FMA:9674]
synonym: "waste substance" EXACT [AEO:0000184]
xref: AEO:0000184
xref: BTO:0000491
xref: EHDAA2_RETIRED:0003184
xref: ENVO:02000022
xref: FMA:9674
xref: galen:Excretion
is_a: UBERON:0000463 ! organism substance
intersection_of: UBERON:0000463 ! organism substance
intersection_of: output_of GO:0007588 ! excretion
relationship: output_of GO:0007588 ! excretion

[Term]
id: UBERON:0000178
name: blood
namespace: uberon
def: "A fluid that is composed of blood plasma and erythrocytes." [FMA:9670, http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/9, Wikipedia:Blood]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "portion of blood" EXACT []
synonym: "vertebrate blood" EXACT []
synonym: "whole blood" RELATED [BTO:0000089]
xref: AAO:0000046
xref: BTO:0000089
xref: CALOHA:TS-0079
xref: EFO:0000296
xref: EHDAA2:0000176
xref: EHDAA:418
xref: EMAPA:16332
xref: ENVO:02000027
xref: EV:0100047
xref: FMA:9670
xref: GAID:965
xref: galen:Blood
xref: MA:0000059
xref: MESH:D001769
xref: MIAA:0000315
xref: NCIT:C12434
xref: TAO:0000007
xref: UMLS:C0005767 {source="ncithesaurus:Blood"}
xref: VHOG:0000224
xref: Wikipedia:Blood
xref: XAO:0000124
xref: ZFA:0000007
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: develops_from UBERON:0006596 ! presumptive blood
relationship: has_part CL:0000232 {source="CL:tm"} ! erythrocyte
relationship: has_part UBERON:0001969 ! blood plasma
relationship: immediate_transformation_of UBERON:0006596 {source="Bgee:AN"} ! presumptive blood
relationship: located_in UBERON:0002049 {source="https://github.com/obophenotype/uberon/issues/1330"} ! vasculature
relationship: part_of UBERON:0002390 ! hematopoietic system
property_value: curator_notes "This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid." xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000007", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000046", ontology="AAO"}
property_value: UBPROP:0000003 "Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000224", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual review of cell and developmental biology (2006) ", source="http://bgee.unil.ch/"}
property_value: x_1.1:contributor https://github.com/cmungall
property_value: x_1.1:contributor https://github.com/tmeehan

[Term]
id: UBERON:0000179
name: haemolymphatic fluid
namespace: uberon
def: "Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs." [http://orcid.org/0000-0002-6601-2165]
synonym: "blood or blood analog" RELATED []
synonym: "circulating fluid" RELATED []
xref: CARO:0000081
is_a: UBERON:0006314 ! bodily fluid
intersection_of: UBERON:0000463 ! organism substance
intersection_of: part_of UBERON:0002193 ! hemolymphoid system
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0002193 ! hemolymphoid system
property_value: term:contributor https://orcid.org/0000-0002-6601-2165
creation_date: 2009-04-08T04:38:19Z

[Term]
id: UBERON:0000209
name: tetrapod frontal bone
namespace: uberon
def: "The bone forming the forehead and roof of the eye orbit." [ISBN:0-683-40008-8, MP:0000107, PMID:7914451, Wikipedia:Frontal_bone]
subset: human_reference_atlas
subset: pheno_slim
synonym: "frontal" NARROW [AAO:0000206]
synonym: "frontal bone" NARROW SENSU [FMA:52734, MA:0001466]
synonym: "os frontal" NARROW SENSU [Wikipedia:Frontal_bone]
synonym: "os frontale" RELATED OMO:0003011 [Wikipedia:Frontal_bone]
xref: AAO:0000206
xref: EMAPA:19016
xref: FMA:52734
xref: GAID:226
xref: MA:0001466
xref: MESH:D005624
xref: NCIT:C32635
xref: SCTID:181793006
xref: UMLS:C0016732 {source="ncithesaurus:Frontal_Bone"}
xref: VHOG:0001324
xref: VSAO:0000208
xref: Wikipedia:Frontal_bone
is_a: UBERON:0002514 ! intramembranous bone
is_a: UBERON:0008907 ! dermal bone
is_a: UBERON:0010428 {source="FMA"} ! flat bone
is_a: UBERON:0011164 ! neurocranium bone
relationship: connected_to UBERON:0001677 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! sphenoid bone
relationship: connected_to UBERON:0001679 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! ethmoid bone
relationship: overlaps UBERON:0001697 ! orbit of skull
relationship: part_of UBERON:0003113 {source="cjm"} ! dermatocranium
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/9/97/Gray136.png" xsd:anyURI
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/5/5b/Frontal_bone.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000008 "fused in humans, paired in other animals" xsd:string
property_value: UBPROP:0000011 "In the mouse the parietal originates from cephalic paraxial mesoderm (Jiang 2000; Morriss-Kay 2001), whereas in the chicken it is traced back to either mesodermal (Noden 1978) or neural crest (Couly 1992, 1993)." xsd:string

[Term]
id: UBERON:0000211
name: ligament
namespace: uberon
def: "Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000073]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "ligament organ" EXACT [FMA:21496]
xref: CALOHA:TS-2145
xref: EFO:0001966
xref: EMAPA:35493
xref: FMA:21496
xref: FMA:30319
xref: galen:Ligament
xref: MA:0000113
xref: MESH:D008022
xref: NCIT:C13046
xref: SCTID:182358004
xref: TAO:0001682
xref: UMLS:C0023685 {source="ncithesaurus:Ligament"}
xref: VHOG:0001272
xref: Wikipedia:Ligament
xref: XAO:0004031
xref: ZFA:0001675
is_a: UBERON:0000062 ! organ
relationship: has_part UBERON:0002384 ! connective tissue
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/9/9a/Knee_diagram.svg" xsd:anyURI
property_value: UBPROP:0000001 "Nonparenchymatous organ that primarily consists of dense connective tissue aggregated into fasciculi by connective tissue. Examples: sutural ligament, radiate sternocostal ligament, ligament of liver, ovarian ligament[FMA][FMA:21496]." xsd:string {source="FMA:21496"}
property_value: UBPROP:0000001 "Portion of connective tissue that connects bone or cartilage.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001682", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000003 "Compared with their Ediacarian predecessor, Cambrian animals in general were characterized by their much stouter bodies. The stoutness of the body is likely due to the formation of ligaments and tendons, which in turn requires the crosslinking of collagen triple helices.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001272", ontology="VHOG", source="PMID:8710894 Ohno S, The notion of the Cambrian pananimalia genome. PNAS (1996)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "this groups both skeletal and non-skeletal ligaments. What is called a 'ligament' in many AOs is actually a skeletal ligament" xsd:string

[Term]
id: UBERON:0000219
name: vertebral foramen of atlas
namespace: uberon
synonym: "vertebral foramen of cervical vertebra 1" EXACT []
xref: FMA:24293
xref: SCTID:281228008
xref: Wikipedia:Atlas_(anatomy)#Vertebral_foramen
is_a: UBERON:0001131 ! vertebral foramen
is_a: UBERON:0005744 ! bone foramen
intersection_of: UBERON:0001131 ! vertebral foramen
intersection_of: part_of UBERON:0001092 ! vertebral bone 1
relationship: part_of UBERON:0001092 ! vertebral bone 1

[Term]
id: UBERON:0000220
name: atlanto-occipital joint
namespace: uberon
def: "The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital." [Wikipedia:Atlanto-occipital_joint]
synonym: "articulatio atlanto-occipitalis" EXACT [FMA:24939]
synonym: "articulatio atlantooccipitalis" RELATED OMO:0003011 [Wikipedia:Atlanto-occipital_joint]
synonym: "atlanto occipital joint" EXACT []
synonym: "atlantooccipital joint" EXACT []
synonym: "craniovertebral joint" EXACT [FMA:24939]
synonym: "occipito atlantal joint" EXACT []
synonym: "occipito-atlantal joint" EXACT []
xref: FMA:24939
xref: MESH:D001269 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0001-9439-5346", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: NCIT:C32158
xref: ncithesaurus:Atlanto-occipital_Joint-Atlanto
xref: SCTID:361831006
xref: UMLS:C0004169 {source="ncithesaurus:Atlanto-occipital_Joint"}
xref: Wikipedia:Atlanto-occipital_joint
is_a: UBERON:0002217 ! synovial joint
is_a: UBERON:0015212 ! lateral structure
intersection_of: UBERON:0002217 ! synovial joint
intersection_of: connects UBERON:0001092 ! vertebral bone 1
intersection_of: connects UBERON:0001676 ! occipital bone
relationship: connects UBERON:0001092 ! vertebral bone 1
relationship: connects UBERON:0001676 ! occipital bone
relationship: in_lateral_side_of UBERON:0006072 {source="FMA-abduced-lr"} ! cervical region of vertebral column
relationship: part_of UBERON:0006072 ! cervical region of vertebral column
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray304.png" xsd:anyURI

[Term]
id: UBERON:0000304
name: tendon sheath
namespace: uberon
def: "A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath." [Wikipedia:Tendon_sheath]
synonym: "synovial tendon sheath" EXACT [FMA:45087]
synonym: "vagina tendinis" RELATED OMO:0003011 [Wikipedia:Tendon_sheath]
xref: BTO:0000051
xref: FMA:45087
xref: FMA:76715
xref: NCIT:C96299
xref: SCTID:361885006
xref: UMLS:C0224856 {source="ncithesaurus:Tendon_Sheath"}
xref: Wikipedia:Tendon_sheath
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: bounding_layer_of UBERON:0000043 ! tendon
relationship: bounding_layer_of UBERON:0000043 ! tendon
relationship: has_part UBERON:0011233 ! synovial membrane of synovial tendon sheath
relationship: has_part UBERON:0011234 ! fibrous membrane of synovial tendon sheath
relationship: part_of UBERON:0000043 ! tendon
property_value: editor_note "TODO - add layer relations. 'tendon sheath' GAT in FMA." xsd:string

[Term]
id: UBERON:0000307
name: blastula
namespace: uberon
alt_id: UBERON:0007011
def: "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence." [Wikipedia:Blastula]
subset: inconsistent_with_fma
synonym: "blastosphere" RELATED [Wikipedia:Blastula]
synonym: "blastula embryo" EXACT [BILA:0000059]
xref: BILA:0000059
xref: BTO:0000128
xref: GAID:1294
xref: MESH:D036703
xref: OGEM:000006
xref: Wikipedia:Blastula
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: develops_from UBERON:0007010 ! cleaving embryo
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png" xsd:anyURI
property_value: editor_note "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula" xsd:string

[Term]
id: UBERON:0000317
name: colonic mucosa
namespace: uberon
alt_id: UBERON:0003347
alt_id: UBERON:0004981
def: "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells." [http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: human_reference_atlas
synonym: "colon mucosa" EXACT [FMA:14984]
synonym: "colon mucous membrane" EXACT [OBOL:automatic]
synonym: "colonic mucosa" EXACT []
synonym: "colonic mucous membrane" EXACT [FMA:14984]
synonym: "large bowel mucosa" EXACT [OBOL:automatic]
synonym: "mucosa of colon" EXACT [FMA:14984]
synonym: "mucosa of large bowel" EXACT [OBOL:automatic]
xref: BTO:0000271
xref: CALOHA:TS-0164
xref: EFO:0003038
xref: EMAPA:27375
xref: FMA:14984
xref: FMA:85388
xref: MA:0003194
xref: SCTID:362157008
is_a: UBERON:0001207 ! mucosa of large intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000320
name: duodenal mucosa
namespace: uberon
alt_id: UBERON:0003348
def: "A mucosa that is part of a duodenum [Automatically generated definition]." [OBOL:automatic]
subset: human_reference_atlas
synonym: "doudenal mucosa" EXACT [FMA:14942]
synonym: "duodenal mucous membrane" EXACT [FMA:14942]
synonym: "duodenum mucosa" RELATED [BTO:0000367]
synonym: "mucosa of duodenum" EXACT [OBOL:automatic]
synonym: "mucous membrane of duodenum" EXACT [OBOL:automatic]
xref: BTO:0000367
xref: CALOHA:TS-0213
xref: EMAPA:27235
xref: FMA:14942
xref: MA:0003207
xref: SCTID:362146003
is_a: UBERON:0001204 ! mucosa of small intestine
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0002114 ! duodenum
relationship: part_of UBERON:0002114 ! duodenum
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000323
name: late embryo
namespace: uberon
def: "An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching." [https://orcid.org/0000-0003-3308-6245]
subset: efo_slim
subset: pheno_slim
synonym: "embryo late growth stage" RELATED [BTO:0000449]
synonym: "embryo late stage" RELATED [BTO:0000449]
synonym: "fetus" NARROW [BTO:0000449]
xref: BTO:0000449
xref: CALOHA:TS-0360
xref: EFO:0001323
xref: FBbt:00005333 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:63919
xref: GAID:552
xref: MESH:D005333
xref: NCIT:C13235
xref: SCTID:83418008
xref: UMLS:C0015965 {source="ncithesaurus:Fetus"}
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000922 ! embryo
intersection_of: existence_starts_and_ends_during UBERON:0007220 ! late embryonic stage
relationship: existence_starts_and_ends_during UBERON:0007220 ! late embryonic stage
property_value: editor_note "TODO - check fetus/embryo. WP: An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination. In humans, it is called an embryo until about eight weeks after fertilization (i.e. ten weeks LMP), and from then it is instead called a fetus." xsd:string
property_value: UBPROP:0000001 "Fetal structure, which is a developmental form of a vertebrate animal at any given time point from 8 weeks of gestation to birth (or hatching). Examples: There is only one fetus[FMA:63919]." xsd:string {source="FMA:63919"}

[Term]
id: UBERON:0000325
name: gastric gland
namespace: uberon
def: "The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin." [MGI:anna]
subset: organ_slim
subset: pheno_slim
xref: BTO:0000503
xref: EMAPA:27181
xref: FMA:14919
is_a: UBERON:0002365 {source="cjm"} ! exocrine gland
is_a: UBERON:0003294 ! gland of foregut
relationship: part_of UBERON:0006924 {source="ISBN:0073040584"} ! stomach glandular epithelium

[Term]
id: UBERON:0000326
name: pancreatic juice
namespace: uberon
def: "Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GO:0030157]
synonym: "pancreatic fluid" RELATED []
synonym: "pancreatic secretion" RELATED []
synonym: "succus pancreaticus" RELATED [BTO:0000504]
xref: BTO:0000504
xref: CALOHA:TS-2235
xref: FMA:62973
xref: GAID:1166
xref: MESH:D010189
is_a: UBERON:0000456 ! secretion of exocrine gland
intersection_of: UBERON:0000456 ! secretion of exocrine gland
intersection_of: produced_by UBERON:0001264 ! pancreas
relationship: produced_by UBERON:0001264 ! pancreas

[Term]
id: UBERON:0000328
name: gut wall
namespace: uberon
def: "The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity)." [http://orcid.org/0000-0002-6601-2165]
synonym: "digestive tract wall" EXACT []
synonym: "wall of alimentary tract" RELATED []
synonym: "wall of digestive tract" EXACT []
synonym: "wall of gut" EXACT [FMA:45653]
xref: BTO:0000547
xref: FMA:45653
is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001555 ! digestive tract
relationship: part_of UBERON:0001555 ! digestive tract
property_value: curator_notes "We model the digestive tract as consisting of two parts: the wall and the lumen." xsd:string

[Term]
id: UBERON:0000332
name: yellow bone marrow
namespace: uberon
def: "Bone marrow in which the fat cells predominate in the meshes of the reticular network." [http://medical-dictionary.thefreedictionary.com/Yellow+Marrow]
synonym: "fat marrow" RELATED [BTO:0000635]
synonym: "medulla ossium flava" EXACT OMO:0003011 [BTO:0000635]
synonym: "yellow marrow" EXACT [BTO:0000635]
xref: BTO:0000635
xref: FMA:74596
xref: SCTID:328639002
xref: SCTID:5023006
is_a: UBERON:0002371 ! bone marrow
intersection_of: UBERON:0002371 ! bone marrow
intersection_of: composed_primarily_of CL:0000136 ! adipocyte
relationship: composed_primarily_of CL:0000136 ! adipocyte
relationship: part_of UBERON:0007195 ! stroma of bone marrow

[Term]
id: UBERON:0000333
name: intestinal gland
namespace: uberon
def: "A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]." [https://orcid.org/0000-0002-6601-2165]
subset: organ_slim
synonym: "bowel mucosa gland" EXACT [OBOL:automatic]
synonym: "bowel mucosa of organ gland" EXACT [OBOL:automatic]
synonym: "bowel mucous membrane gland" EXACT [OBOL:automatic]
synonym: "bowel organ mucosa gland" EXACT [OBOL:automatic]
synonym: "gland of bowel mucosa" EXACT [OBOL:automatic]
synonym: "gland of bowel mucosa of organ" EXACT [OBOL:automatic]
synonym: "gland of bowel mucous membrane" EXACT [OBOL:automatic]
synonym: "gland of bowel organ mucosa" EXACT [OBOL:automatic]
synonym: "gland of intestinal mucosa" EXACT [OBOL:automatic]
synonym: "gland of intestine mucosa" EXACT [OBOL:automatic]
synonym: "gland of intestine mucosa of organ" EXACT [OBOL:automatic]
synonym: "gland of intestine mucous membrane" EXACT [OBOL:automatic]
synonym: "gland of intestine organ mucosa" EXACT [OBOL:automatic]
synonym: "gland of mucosa of bowel" EXACT [OBOL:automatic]
synonym: "gland of mucosa of intestine" EXACT [OBOL:automatic]
synonym: "gland of mucosa of organ of bowel" EXACT [OBOL:automatic]
synonym: "gland of mucosa of organ of intestine" EXACT [OBOL:automatic]
synonym: "gland of mucous membrane of bowel" EXACT [OBOL:automatic]
synonym: "gland of mucous membrane of intestine" EXACT [OBOL:automatic]
synonym: "gland of organ mucosa of bowel" EXACT [OBOL:automatic]
synonym: "gland of organ mucosa of intestine" EXACT [OBOL:automatic]
synonym: "glandula intestinalis" EXACT [FMA:15052]
synonym: "glandulae intestinales" RELATED []
synonym: "intestinal mucosa gland" EXACT [OBOL:automatic]
synonym: "intestine mucosa gland" EXACT [OBOL:automatic]
synonym: "intestine mucosa of organ gland" EXACT [OBOL:automatic]
synonym: "intestine mucous membrane gland" EXACT [OBOL:automatic]
synonym: "intestine organ mucosa gland" EXACT [OBOL:automatic]
synonym: "mucosa of bowel gland" EXACT [OBOL:automatic]
synonym: "mucosa of intestine gland" EXACT [OBOL:automatic]
synonym: "mucosa of organ of bowel gland" EXACT [OBOL:automatic]
synonym: "mucosa of organ of intestine gland" EXACT [OBOL:automatic]
synonym: "mucous membrane of bowel gland" EXACT [OBOL:automatic]
synonym: "mucous membrane of intestine gland" EXACT [OBOL:automatic]
synonym: "organ mucosa of bowel gland" EXACT [OBOL:automatic]
synonym: "organ mucosa of intestine gland" EXACT [OBOL:automatic]
xref: BTO:0000640
xref: FMA:15052
xref: SCTID:266297002
is_a: UBERON:0003408 ! gland of digestive tract
intersection_of: UBERON:0002530 ! gland
intersection_of: part_of UBERON:0001242 ! intestinal mucosa
relationship: part_of UBERON:0001242 ! intestinal mucosa
property_value: UBPROP:0000012 "Note that some sources treat 'intestinal gland' as synonymous with crypts" xsd:string

[Term]
id: UBERON:0000344
name: mucosa
namespace: uberon
def: "A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]." [Wikipedia:Mucous_membrane]
subset: pheno_slim
synonym: "mucosa of organ" EXACT [FMA:85355]
synonym: "mucosa of organ part" EXACT [FMA:85358]
synonym: "mucosal region" EXACT [FMA:85358]
synonym: "mucous membrane" EXACT [FMA:85355]
synonym: "organ mucosa" EXACT [FMA:85355]
synonym: "region of mucosa" RELATED [FMA:85358]
synonym: "tunica mucosa" RELATED OMO:0003011 [BTO:0000886, Wikipedia:Mucous_membrane]
xref: AEO:0000199
xref: BTO:0000886
xref: CALOHA:TS-2031
xref: EHDAA2_RETIRED:0003234
xref: EV:0100382
xref: FMA:85355
xref: FMA:85358
xref: GAID:297
xref: galen:Mucosa
xref: MESH:D009092
xref: NCIT:C13166
xref: SCTID:361693009
xref: UMLS:C0026724 {source="ncithesaurus:Mucosa"}
xref: Wikipedia:Mucous_membrane
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 ! organ component layer
relationship: has_part UBERON:0000483 ! epithelium
relationship: has_part UBERON:0002384 ! connective tissue
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png" xsd:anyURI
property_value: RO:0002171 UBERON:0000009
property_value: UBPROP:0000007 "mucosal" xsd:string
property_value: UBPROP:0000012 "FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000353
name: parenchyma
namespace: uberon
def: "Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues." [Wikipedia:Parenchyma]
xref: BTO:0000999 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: BTO:0001539 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: EHDAA:3015
xref: EHDAA:3905
xref: EHDAA:3999
xref: EHDAA:4005
xref: EHDAA:6899
xref: EHDAA:6903
xref: EHDAA:6994
xref: EHDAA:8086
xref: EHDAA:9182
xref: EHDAA:9190
xref: EHDAA:9196
xref: EHDAA:9202
xref: FMA:45732
xref: NCIT:C74601
xref: UMLS:C0933845 {source="ncithesaurus:Parenchyma"}
xref: Wikipedia:Parenchyma
is_a: UBERON:0000064 ! organ part
disjoint_from: UBERON:0003891 ! stroma
relationship: capable_of GO:0032501 ! multicellular organismal process
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: UBPROP:0000007 "parenchymal" xsd:string
property_value: UBPROP:0000011 "Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin" xsd:string {source="WP"}
property_value: UBPROP:0000012 "the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000355
name: pharyngeal mucosa
namespace: uberon
alt_id: UBERON:0003344
def: "A mucosa that is part of a pharynx [Automatically generated definition]." [OBOL:automatic]
synonym: "mucosa of organ of pharynx" EXACT [OBOL:automatic]
synonym: "mucosa of pharynx" EXACT [OBOL:automatic]
synonym: "mucous membrane of pharynx" EXACT [FMA:55031, OBOL:automatic]
synonym: "mucous membrane of the pharynx" RELATED [BTO:0001047]
synonym: "organ mucosa of pharynx" EXACT [OBOL:automatic]
synonym: "pharynx mucosa" EXACT [OBOL:automatic]
synonym: "pharynx mucosa of organ" EXACT [OBOL:automatic]
synonym: "pharynx mucous membrane" EXACT [OBOL:automatic]
synonym: "pharynx organ mucosa" EXACT [OBOL:automatic]
synonym: "tunica mucosa pharyngea" EXACT OMO:0003011 [FMA:55031, FMA:TA]
synonym: "tunica mucosa pharyngis" EXACT []
xref: BTO:0001047
xref: EMAPA:26957
xref: FMA:55031
xref: MA:0003143
xref: SCTID:362121003
is_a: UBERON:0004785 ! respiratory system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001042 ! chordate pharynx
relationship: part_of UBERON:0001042 ! chordate pharynx

[Term]
id: UBERON:0000358
name: blastocyst
namespace: uberon
def: "The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]." [GO:0001824, Wikipedia:Blastocyst]
subset: efo_slim
synonym: "blastocystis" RELATED OMO:0003011 [Wikipedia:Blastocyst]
synonym: "blastula" RELATED [FMA:83041]
xref: BTO:0001099
xref: CALOHA:TS-0076
xref: EFO:0000295
xref: EMAPA:36035
xref: EV:0100394
xref: FMA:83041
xref: GAID:1153
xref: MESH:D001755
xref: NCIT:C13739
xref: SCTID:308837009
xref: UMLS:C1281743 {source="ncithesaurus:Blastocyst"}
xref: Wikipedia:Blastocyst
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000085 ! morula
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
relationship: has_part UBERON:0000087 ! inner cell mass
relationship: has_part UBERON:0000088 ! trophoblast
relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>
relationship: part_of UBERON:0000307 ! blastula
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/7/72/Blastocyst_English.svg" xsd:anyURI
property_value: editor_note "Gilbert fig11.32 has blastocyst has giving rise to ICM and trophoblast (which in this source is a synonym for trophectoderm)" xsd:string

[Term]
id: UBERON:0000361
name: red bone marrow
namespace: uberon
def: "The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream." [http://medical-dictionary.thefreedictionary.com/red+marrow]
synonym: "medulla ossium rubra" EXACT OMO:0003011 [BTO:0001160]
synonym: "parenchyma of none marrow marrow" RELATED [http://orcid.org/0000-0002-6601-2165]
synonym: "parenchymal red marrow" EXACT [http://orcid.org/0000-0002-6601-2165]
synonym: "red marrow" EXACT [BTO:0001160]
xref: BTO:0001160
xref: FMA:74595
xref: SCTID:328538003
xref: SCTID:75330005
is_a: UBERON:0002371 ! bone marrow
intersection_of: UBERON:0002371 ! bone marrow
intersection_of: composed_primarily_of CL:0000988 ! hematopoietic cell
relationship: composed_primarily_of CL:0000988 ! hematopoietic cell
relationship: part_of UBERON:0012429 ! hematopoietic tissue

[Term]
id: UBERON:0000371
name: syncytiotrophoblast
namespace: uberon
def: "Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated)." [http://embryology.med.unsw.edu.au/Notes/placenta5.htm, Wikipedia:Syncytiotrophoblast]
synonym: "syncitiotrophoblast" RELATED []
synonym: "syncitiotrophoblastus" RELATED OMO:0003011 [Wikipedia:Syncytiotrophoblast]
synonym: "syncytial trophoblast" EXACT [FMA:83040]
synonym: "syntrophoblast" RELATED []
synonym: "syntrophoblast layer" EXACT [ISBN:0073040584]
xref: BTO:0001335
xref: EHDAA:129
xref: EHDAA:91
xref: EMAPA:16068
xref: FMA:83040
xref: NCIT:C33918
xref: SCTID:256965005
xref: UMLS:C1135936 {source="ncithesaurus:Syncytiotrophoblast"}
xref: Wikipedia:Syncytiotrophoblast
is_a: UBERON:0002050 {source="FMA"} ! embryonic structure
relationship: composed_primarily_of CL:0000525 ! syncytiotrophoblast cell
relationship: part_of UBERON:0004364 {source="EMAPA"} ! ectoplacental cone
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray36.png" xsd:anyURI

[Term]
id: UBERON:0000377
name: maxillary nerve
namespace: uberon
def: "The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses." [MP:0009799, Wikipedia:Maxillary_nerve]
subset: human_reference_atlas
subset: pheno_slim
synonym: "maxillary division [V2]" EXACT [FMA:52724]
synonym: "maxillary division [Vb]" EXACT [FMA:52724]
synonym: "maxillary division of fifth cranial nerve" EXACT [FMA:52724]
synonym: "maxillary division of trigeminal nerve (Vb; V2)" EXACT [FMA:52724]
synonym: "maxillary nerve [V2]" EXACT [FMA:52724]
synonym: "maxillary nerve [Vb]" EXACT [FMA:52724]
synonym: "n. maxillaris" RELATED OMO:0003011 [Wikipedia:Maxillary_nerve]
synonym: "nervus maxillaris" RELATED [BTO:0001378]
synonym: "nervus maxillaris (Vb; V2)" EXACT [FMA:52724]
synonym: "nervus maxillaris [v2]" EXACT OMO:0003011 [FMA:52724, FMA:TA]
synonym: "nervus maxillaris [vb]" EXACT OMO:0003011 [FMA:52724, FMA:TA]
synonym: "ramus maxillaris (ramus V2)" EXACT [AAO:0010670]
synonym: "second division of fifth cranial nerve" EXACT [FMA:52724]
synonym: "second division of trigeminal nerve" EXACT [FMA:52724]
synonym: "trigeminal nerve maxillary division" RELATED [EMAPA:17799]
synonym: "trigeminal V nerve maxillary division" EXACT [MA:0001103]
xref: AAO:0010670
xref: BTO:0001378
xref: EHDAA2:0002087
xref: EMAPA:17799
xref: FMA:52724
xref: GAID:836
xref: MA:0001103
xref: MESH:D008442
xref: SCTID:280211001
xref: VHOG:0001346
xref: Wikipedia:Maxillary_nerve
is_a: UBERON:0011779 ! nerve of head region
relationship: branching_part_of UBERON:0001645 ! trigeminal nerve
relationship: part_of UBERON:0001645 ! trigeminal nerve
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/a/a9/Gray779.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Medial ramus (sensory) of the trigeminal nerve.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000002 "relationship loss: part_of trunk maxillary-mandibularis (AAO:0010669)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010670", ontology="AAO"}

[Term]
id: UBERON:0000379
name: tracheal mucosa
namespace: uberon
def: "A mucosa that is part of a respiratory airway." [OBOL:automatic]
synonym: "mucosa of organ of trachea" EXACT [OBOL:automatic]
synonym: "mucosa of organ of windpipe" EXACT [OBOL:automatic]
synonym: "mucosa of trachea" EXACT [OBOL:automatic]
synonym: "mucosa of windpipe" EXACT [OBOL:automatic]
synonym: "mucous membrane of trachea" EXACT [FMA:7471, OBOL:automatic]
synonym: "mucous membrane of windpipe" EXACT [OBOL:automatic]
synonym: "organ mucosa of trachea" EXACT [OBOL:automatic]
synonym: "organ mucosa of windpipe" EXACT [OBOL:automatic]
synonym: "trachea mucosa" EXACT [OBOL:automatic]
synonym: "trachea mucosa of organ" EXACT [OBOL:automatic]
synonym: "trachea mucous membrane" EXACT [OBOL:automatic]
synonym: "trachea organ mucosa" EXACT [OBOL:automatic]
synonym: "tracheal mucous membrane" EXACT [FMA:7471]
synonym: "tunica mucosa (tracheae)" EXACT [FMA:7471]
synonym: "tunica mucosa tracheae" EXACT OMO:0003011 [FMA:7471, FMA:TA]
synonym: "windpipe mucosa" EXACT [OBOL:automatic]
synonym: "windpipe mucosa of organ" EXACT [OBOL:automatic]
synonym: "windpipe mucous membrane" EXACT [OBOL:automatic]
synonym: "windpipe organ mucosa" EXACT [OBOL:automatic]
xref: BTO:0001390
xref: FMA:7471
xref: SCTID:660006
is_a: UBERON:0004785 ! respiratory system mucosa
intersection_of: UBERON:0000344 ! mucosa
intersection_of: part_of UBERON:0001005 ! respiratory airway
relationship: part_of UBERON:0001005 ! respiratory airway

[Term]
id: UBERON:0000383
name: musculature of body
namespace: uberon
def: "The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]." [VSAO:0000033]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
synonym: "muscle system" EXACT []
synonym: "muscle system of body" EXACT []
synonym: "muscular system" EXACT [FMA:72954]
synonym: "musculature system" EXACT [BILA:0000088]
synonym: "muskelsystem" RELATED [BTO:0001485]
synonym: "set of all muscles" EXACT [FMA:72954]
synonym: "set of muscles of body" EXACT [FMA:72954]
synonym: "vertebrate muscular system" EXACT [BTO:0001369]
xref: AAO:0000307
xref: BILA:0000088
xref: BTO:0001369
xref: BTO:0001485
xref: EFO:0000801
xref: EMAPA:35578
xref: FMA:72954
xref: MA:0002888
xref: MAT:0000025
xref: MIAA:0000025
xref: VSAO:0000033
xref: XAO:0004042
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: composed_primarily_of UBERON:0001015 ! musculature
relationship: capable_of GO:0003012 ! muscle system process
relationship: composed_primarily_of UBERON:0001015 ! musculature
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: editor_note "consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77" xsd:string
property_value: RO:0002161 NCBITaxon:6040
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Anatomical system that consists of the muscles of the body.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000033", ontology="VSAO", source="VSAO:curator"}
property_value: UBPROP:0000012 "we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0000389
name: lens cortex
namespace: uberon
def: "Tissue that surrounds the lens nucleus." [http://www.thefreedictionary.com/lens+cortex]
subset: human_reference_atlas
synonym: "cortex of lens" EXACT [FMA:58970]
xref: BTO:0001632
xref: CALOHA:TS-0542
xref: FMA:58970
xref: MESH:D007904
xref: SCTID:280626006
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0000479 ! tissue
intersection_of: surrounds UBERON:0000390 ! lens nucleus
relationship: develops_from UBERON:0005614 ! lens anterior epithelium
relationship: part_of UBERON:0000965 ! lens of camera-type eye
relationship: surrounds UBERON:0000390 ! lens nucleus
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000390
name: lens nucleus
namespace: uberon
def: "The core of the crystalline lens, surrounded by the cortex." [BTO:0001633]
subset: human_reference_atlas
synonym: "nucleus of lens" EXACT [FMA:58971]
xref: BTO:0001633
xref: FMA:58971
xref: MESH:D007907
xref: SCTID:280628007
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0034944 ! zone of organ
intersection_of: UBERON:0034944 ! zone of organ
intersection_of: surrounded_by UBERON:0000389 ! lens cortex
relationship: develops_from UBERON:0005614 ! lens anterior epithelium
relationship: part_of UBERON:0000965 ! lens of camera-type eye
relationship: surrounded_by UBERON:0000389 ! lens cortex
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000397
name: colonic epithelium
namespace: uberon
def: "An epithelium that is part of a colon [Automatically generated definition]." [OBOL:automatic]
subset: human_reference_atlas
subset: vertebrate_core
synonym: "colon epithelial tissue" EXACT [OBOL:automatic]
synonym: "colon epithelium" EXACT [FMA:17302, OBOL:automatic]
synonym: "epithelial tissue of colon" EXACT [OBOL:automatic]
synonym: "epithelial tissue of large bowel" EXACT [OBOL:automatic]
synonym: "epithelium of colon" EXACT [OBOL:automatic]
synonym: "epithelium of large bowel" EXACT [OBOL:automatic]
synonym: "large bowel epithelial tissue" EXACT [OBOL:automatic]
synonym: "large bowel epithelium" EXACT [OBOL:automatic]
synonym: "posterior intestine epithelium" EXACT [ZFA:0005128]
xref: BTO:0001709
xref: CALOHA:TS-0163
xref: EMAPA:18941
xref: FMA:17302
xref: MA:0003195
xref: SCTID:42978003
xref: TAO:0005128
xref: ZFA:0005128
is_a: UBERON:0001278 ! epithelium of large intestine
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001155 ! colon
relationship: part_of UBERON:0001155 ! colon
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Intestinal epithelium which lines the lumen of the posterior intestine.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005128", ontology="TAO", source="ZFIN:curator"}

[Term]
id: UBERON:0000409
name: serous gland
namespace: uberon
def: "A gland in which the principal secretory cells are serous secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm]
subset: organ_slim
subset: pheno_slim
xref: BTO:0001837
xref: EMAPA:37950 {source="MA:th"}
xref: FMA:62889
xref: Wikipedia:Serous_gland
is_a: UBERON:0002365 ! exocrine gland
intersection_of: UBERON:0002365 ! exocrine gland
intersection_of: has_part CL:0000313 ! serous secreting cell
relationship: has_part CL:0000313 ! serous secreting cell
relationship: has_part UBERON:0013232 ! serous acinus
relationship: produces UBERON:0007794 ! secretion of serous gland
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
property_value: UBPROP:0000001 "glands that secrete watery albuminous material that often contains enzymes[MP:0008052]." xsd:string {source="MP:0008052"}

[Term]
id: UBERON:0000414
name: mucous gland
namespace: uberon
def: "A gland in which the principal secretory cells are mucus secreting cells." [http://orcid.org/0000-0002-6601-2165, http://www.siumed.edu/~dking2/intro/glands.htm]
subset: organ_slim
synonym: "glandula mucosa" EXACT OMO:0003011 [Wikipedia:Mucous_gland]
synonym: "muciparous gland" RELATED [BTO:0001979]
synonym: "mucous secreting gland" RELATED []
synonym: "mucus gland" RELATED []
synonym: "mucus-secreting gland" RELATED []
xref: AAO:0010601
xref: BTO:0001979
xref: EMAPA:37913 {source="MA:th"}
xref: FMA:62888
xref: Wikipedia:Mucous_gland
is_a: UBERON:0002365 ! exocrine gland
intersection_of: UBERON:0002365 ! exocrine gland
intersection_of: has_part CL:0000319 ! mucus secreting cell
relationship: capable_of GO:0070254 ! mucus secretion
relationship: has_part CL:0000319 ! mucus secreting cell
relationship: produces UBERON:0000912 ! mucus
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png" xsd:anyURI
property_value: UBPROP:0000008 "In frogs and salamanders, this is the smaller of the two types of gland, the other being the granular (poison) gland. In these species the mucous gland is a cluster of cells that release secretion into a common duct[Kardong]" xsd:string {scope="NCBITaxon:8292", source="ISBN:0073040584"}

[Term]
id: UBERON:0000415
name: artery wall
namespace: uberon
def: "An anatomical wall that is part of an artery [Automatically generated definition]." [OBOL:automatic]
synonym: "arterial wall" EXACT [FMA:14155]
synonym: "wall of artery" EXACT [FMA:14155]
xref: BTO:0002009
xref: FMA:14155
xref: galen:ArterialWall
is_a: UBERON:0035965 ! wall of blood vessel
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001637 ! artery
relationship: part_of UBERON:0001637 ! artery

[Term]
id: UBERON:0000440
name: trabecula
namespace: uberon
def: "A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]." [GO:0060343, Wikipedia:Trabecula]
subset: grouping_class
subset: pheno_slim
synonym: "trabeculae" EXACT OMO:0003004 []
xref: BTO:0002501
xref: FMA:85273
xref: Wikipedia:Trabecula
is_a: UBERON:0000064 ! organ part
relationship: has_part UBERON:0002384 ! connective tissue
relationship: has_quality PATO:0001873 ! cylindrical
property_value: UBPROP:0000007 "trabecular" xsd:string

[Term]
id: UBERON:0000442
name: right testicular vein
namespace: uberon
def: "A vein that drains the left pampiniform plexus and empties into the left renal vein." [Dorlands_Medical_Dictionary:MerckSource]
subset: human_reference_atlas
synonym: "right spermatic vein" EXACT [MA:0002220]
synonym: "vena testicularis (adrenalis) dextra" EXACT [FMA:14341]
synonym: "vena testicularis dextra" RELATED [BTO:0002679]
synonym: "vena testicularis sinistra" RELATED [BTO:0002680]
xref: BTO:0002679
xref: EMAPA:37383 {source="MA:th"}
xref: FMA:14341
xref: MA:0002220
xref: NCIT:C52697
xref: SCTID:53500001
is_a: UBERON:0001144 ! testicular vein
intersection_of: UBERON:0001144 ! testicular vein
intersection_of: drains UBERON:0004534 ! right testis
relationship: connected_to UBERON:0001142 ! left renal vein
relationship: drains UBERON:0004534 ! right testis
relationship: in_left_side_of UBERON:0000468 ! multicellular organism
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000443
name: left testicular vein
namespace: uberon
def: "A vein that drains the right pampiniform plexus and empties into the inferior vena cava." [Dorlands_Medical_Dictionary:MerckSource]
subset: human_reference_atlas
synonym: "left spermatic vein" EXACT [MA:0002219]
synonym: "vena testicularis dextra" RELATED [BTO:0002679]
synonym: "vena testicularis sinistra" RELATED [BTO:0002680]
xref: BTO:0002680
xref: EMAPA:37167 {source="MA:th"}
xref: FMA:14345
xref: MA:0002219
xref: NCIT:C52696
xref: SCTID:90988008
is_a: UBERON:0001144 ! testicular vein
intersection_of: UBERON:0001144 ! testicular vein
intersection_of: drains UBERON:0004533 ! left testis
relationship: connected_to UBERON:0001142 ! left renal vein
relationship: drains UBERON:0004533 ! left testis
relationship: in_left_side_of UBERON:0000468 ! multicellular organism
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000456
name: secretion of exocrine gland
namespace: uberon
alt_id: UBERON:0006540
def: "A portion of organism substance that is produced by exocrine glands." [http://orcid.org/0000-0002-6601-2165]
synonym: "bodily secretion" EXACT [MESH:D012634]
synonym: "exocrine gland fluid" RELATED []
synonym: "exocrine gland fluid or secretion" RELATED []
synonym: "exocrine gland fluid/secretion" EXACT [MA:0002504]
synonym: "exocrine gland secretion" RELATED []
synonym: "external secretion" RELATED [BTO:0002977]
synonym: "secreted substance" EXACT []
synonym: "secretion" BROAD [FMA:9675]
xref: AEO:0001005
xref: BTO:0002977
xref: BTO:0002979
xref: EMAPA:36535
xref: FMA:9675
xref: galen:Secretion
xref: MA:0002504
xref: MESH:D012634
xref: NCIT:C34062
xref: UMLS:C1516992 {source="ncithesaurus:Exocrine_Gland_Fluid_or_Secretion"}
is_a: UBERON:0000463 ! organism substance
intersection_of: UBERON:0000463 ! organism substance
intersection_of: produced_by UBERON:0002365 ! exocrine gland
relationship: produced_by UBERON:0002365 ! exocrine gland
property_value: UBPROP:0000012 "BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions" xsd:string {external_ontology="BTO"}

[Term]
id: UBERON:0000459
name: uterine wall
namespace: uberon
def: "An anatomical wall that is part of a uterus [Automatically generated definition]." [OBOL:automatic]
synonym: "anatomical wall of uterus" EXACT [OBOL:automatic]
synonym: "uterus anatomical wall" EXACT [OBOL:automatic]
synonym: "uterus wall" EXACT [OBOL:automatic]
synonym: "wall of uterus" EXACT [OBOL:automatic]
xref: BTO:0003083
xref: FMA:17560
xref: SCTID:245485002
is_a: UBERON:0000060 ! anatomical wall
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000995 ! uterus
relationship: part_of UBERON:0000995 ! uterus

[Term]
id: UBERON:0000463
name: organism substance
namespace: uberon
def: "Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body." [http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: pheno_slim
subset: upper_level
synonym: "body fluid or substance" EXACT [MA:0002450]
synonym: "body substance" EXACT [FMA:9669]
synonym: "organism substance" EXACT [CARO:0000004]
synonym: "portion of body substance" EXACT [FMA:9669]
synonym: "portion of organism substance" EXACT [ZFA:0001487]
xref: AAO:0010839
xref: AEO:0000004
xref: BILA:0000004
xref: CALOHA:TS-2101
xref: CARO:0000004
xref: EHDAA2:0003004
xref: EMAPA:35178
xref: FBbt:00007019 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:9669
xref: galen:BodySubstance
xref: HAO:0000004
xref: MA:0002450
xref: NCIT:C13236
xref: SPD:0000008
xref: TAO:0001487
xref: TGMA:0001824
xref: VHOG:0001726
xref: XAO:0004001
xref: ZFA:0001487
is_a: UBERON:0000465 ! material anatomical entity
relationship: has_quality PATO:0002198 ! quality of a substance
relationship: part_of UBERON:0000468 {notes="this relationship may be too strong and may be weakened in future"} ! multicellular organism
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000464
name: anatomical space
namespace: uberon
def: "Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures." [http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: upper_level
synonym: "anatomical spaces" RELATED OMO:0003004 [ZFA:0001643]
synonym: "lumen" BROAD []
synonym: "lumen space" EXACT []
synonym: "space" BROAD []
xref: AAO:0010110
xref: AEO:0000005
xref: BILA:0000005
xref: CARO:0000005
xref: EHDAA2:0003005
xref: FBbt:00007017 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:5897
xref: HAO:0000005
xref: NCIT:C94478
xref: TAO:0001668
xref: TGMA:0001825
xref: UMLS:C0524461 {source="ncithesaurus:Lumen_Space"}
xref: VHOG:0001728
xref: XAO:0003190
xref: ZFA:0001643
is_a: UBERON:0000466 ! immaterial anatomical entity
relationship: surrounded_by UBERON:0000061 ! anatomical structure
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000465
name: material anatomical entity
namespace: uberon
def: "Anatomical entity that has mass." [http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: human_subset
subset: mouse_subset
subset: upper_level
xref: AAO:0010264
xref: AEO:0000006
xref: BILA:0000006
xref: CARO:0000006
xref: EHDAA2:0003006
xref: FBbt:00007016 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:67165
xref: HAO:0000006
xref: TAO:0001836
xref: TGMA:0001826
xref: VHOG:0001721
is_a: BFO:0000040 ! material entity
is_a: UBERON:0001062 ! anatomical entity
disjoint_from: UBERON:0000466 ! immaterial anatomical entity
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000466
name: immaterial anatomical entity
namespace: uberon
def: "Anatomical entity that has no mass." [http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: upper_level
synonym: "immaterial physical anatomical entity" EXACT [FMA:67112]
xref: AAO:0010265
xref: AEO:0000007
xref: BILA:0000007
xref: CARO:0000007
xref: EHDAA2:0003007
xref: FBbt:00007015 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:67112
xref: HAO:0000007
xref: TAO:0001835
xref: TGMA:0001827
xref: VHOG:0001727
is_a: BFO:0000141 ! immaterial entity
is_a: UBERON:0001062 ! anatomical entity
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000467
name: anatomical system
namespace: uberon
def: "Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function." [CARO:0000011]
subset: common_anatomy
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: upper_level
synonym: "anatomical systems" RELATED OMO:0003004 [ZFA:0001439]
synonym: "body system" EXACT [BIRNLEX:14]
synonym: "connected anatomical system" EXACT [CARO:0000011]
synonym: "organ system" EXACT []
synonym: "system" BROAD [GO:0048731]
xref: AAO:0000007
xref: AEO:0000011
xref: BILA:0000011
xref: BIRNLEX:14
xref: BSA:0000049
xref: CALOHA:TS-2088
xref: CARO:0000011
xref: EHDAA2:0003011
xref: EHDAA:392
xref: EMAPA:16103
xref: EV:0100000
xref: FBbt:00004856 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7149
xref: galen:AnatomicalSystem
xref: HAO:0000011
xref: IDOMAL:0002460 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: MA:0000003
xref: NCIT:C12919
xref: SCTID:278195005
xref: TAO:0001439
xref: TGMA:0001831
xref: UMLS:C0460002 {source="ncithesaurus:Organ_System"}
xref: VHOG:0001725
xref: WBbt:0005746
xref: WBbt:0005763
xref: Wikipedia:Organ_system
xref: XAO:0003002
xref: ZFA:0001439
is_a: UBERON:0000061 ! anatomical structure
relationship: existence_starts_during_or_after UBERON:0000111 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! organogenesis stage
relationship: has_part UBERON:0000062 ! organ
relationship: part_of UBERON:0000468 ! multicellular organism
relationship: seeAlso EHDAA2:0001330
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0000468
name: multicellular organism
namespace: uberon
def: "Anatomical structure that is an individual member of a species and consists of more than one cell." [CARO:0000012, http://orcid.org/0000-0001-9114-8737, Wikipedia:Multi-cellular_organism]
subset: common_anatomy
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: upper_level
synonym: "body" RELATED [AEO:0000103, BIRNLEX:18, FMA:256135, NCIT:C13041]
synonym: "Koerper" RELATED [BTO:0001489]
synonym: "multi-cellular organism" EXACT [CARO:0000012]
synonym: "organism" BROAD [FBbt:00000001, VHOG:0000671, WBbt:0007833]
synonym: "whole body" RELATED [BTO:0001489]
synonym: "whole organism" RELATED [FBbt:00000001]
xref: AAO:0010026
xref: AEO:0000191
xref: BILA:0000012
xref: BIRNLEX:18
xref: BSA:0000038
xref: BTO:0000042
xref: CARO:0000012
xref: EFO:0002906
xref: EHDAA2:0003103
xref: EHDAA2:0003191
xref: EHDAA:1
xref: EMAPA:25765
xref: EV:0100016
xref: FBbt:00000001 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:256135
xref: galen:Organism
xref: HAO:0000012
xref: NCIT:C13041
xref: ncithesaurus:Whole_Organism
xref: SCTID:243928005
xref: TADS:0000001
xref: TAO:0001094
xref: TGMA:0001832
xref: VHOG:0000671
xref: WBbt:0007833
xref: Wikipedia:Multi-cellular_organism
xref: XAO:0003004
xref: ZFA:0001094
is_a: UBERON:0010000 ! multicellular anatomical structure
property_value: editor_note "TODO - split body and mc organism? body continues after death stage" xsd:string
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751
property_value: UBPROP:0000007 "organismal" xsd:string

[Term]
id: UBERON:0000471
name: compound organ component
namespace: uberon
def: "Multi-tissue structure that is part of a compound organ." [CARO:0000019, http://orcid.org/0000-0001-9114-8737]
subset: upper_level
synonym: "compound organ components" RELATED OMO:0003004 [ZFA:0001489]
xref: AAO:0010017
xref: AEO:0000019
xref: BILA:0000019
xref: CARO:0000019
xref: EHDAA2:0003019
xref: HAO:0000019
xref: TAO:0001489
xref: TGMA:0001835
xref: XAO:0003039
xref: ZFA:0001489
is_a: UBERON:0000481 ! multi-tissue structure
relationship: part_of UBERON:0003103 ! compound organ
property_value: curator_notes "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" xsd:string

[Term]
id: UBERON:0000473
name: testis
namespace: uberon
alt_id: UBERON:0002117
def: "A gonad of a male animal. A gonad produces and releases sperm." [http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "gonad of male genitalia" EXACT [OBOL:automatic]
synonym: "gonad of male reproductive system" EXACT [OBOL:automatic]
synonym: "male gonad" EXACT [OBOL:automatic]
synonym: "orchis" RELATED [BTO:0001363]
synonym: "testes" RELATED OMO:0003004 []
synonym: "testicle" EXACT [FMA:7210]
synonym: "testiculus" RELATED OMO:0003011 [BTO:0001363]
xref: AAO:0000606
xref: BILA:0000124
xref: BSA:0000085
xref: BTO:0001363
xref: CALOHA:TS-1030
xref: EFO:0000984
xref: EHDAA2:0002007
xref: EHDAA:8146
xref: EMAPA:17972
xref: EV:0100102
xref: FBbt:00004928 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7210
xref: GAID:396
xref: galen:Testis
xref: HAO:0001007
xref: MA:0000411
xref: MAT:0000132
xref: MESH:D013737
xref: MIAA:0000132
xref: NCIT:C12412
xref: SCTID:181431007
xref: TAO:0000598
xref: UMLS:C0039597 {source="ncithesaurus:Testis"}
xref: VHOG:0000252
xref: WBbt:0006794
xref: Wikipedia:Testis
xref: XAO:0000157
xref: ZFA:0000598
is_a: UBERON:0000991 ! gonad
is_a: UBERON:0003135 ! male reproductive organ
intersection_of: UBERON:0000991 ! gonad
intersection_of: part_of UBERON:0000079 ! male reproductive system
disjoint_from: UBERON:0000992 ! ovary
disjoint_from: UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: in_lateral_side_of UBERON:0000468 {gci_relation="part_of", gci_filler="NCBITaxon:7742", notes="vertebrates"} ! multicellular organism
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c3/Gray1144.png" xsd:anyURI
property_value: UBPROP:0000001 "Male reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000598", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000252", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "testicular" xsd:string
property_value: UBPROP:0000008 "The testes are descended in metatherian and eutherian mammals, first transabdominally, then inguinoscrotally" xsd:string {source="ISBN:0123971756", taxon="NCBITaxon:40674"}

[Term]
id: UBERON:0000474
name: female reproductive system
namespace: uberon
def: "The organs and associated structures associated with bearing offspring in a female animal." [http://orcid.org/0000-0002-6601-2165, MP:0001119, Wikipedia:Female_genitalia]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "female genital system" RELATED []
synonym: "female genital tract" RELATED []
synonym: "female genitalia" RELATED []
synonym: "female genitals" RELATED OMO:0003004 [XAO:0000156]
synonym: "female organism genitalia" EXACT [OBOL:automatic]
synonym: "female organism reproductive system" EXACT [OBOL:automatic]
synonym: "female reproductive tract" RELATED [MA:0000381]
synonym: "genitalia of female organism" EXACT [OBOL:automatic]
synonym: "gynaecological tissue" RELATED [BTO:0000083]
synonym: "reproductive system of female organism" EXACT [OBOL:automatic]
synonym: "systema genitale femininum" RELATED [BTO:0000083]
xref: BTO:0000083
xref: CALOHA:TS-1303
xref: EFO:0000969
xref: EHDAA2:0000506
xref: EHDAA:8116
xref: EMAPA:17959
xref: EV:0100110
xref: FBbt:00004864 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45663
xref: GAID:364
xref: HAO:0000324
xref: MA:0000381
xref: MESH:D005836
xref: MIAA:0000028
xref: NCIT:C12402
xref: SCTID:361386004
xref: TGMA:0000635
xref: UMLS:C0700038 {source="ncithesaurus:Female_Reproductive_System"}
xref: VHOG:0000726
xref: Wikipedia:Female_genitalia
xref: WikipediaCategory:Female_reproductive_system
xref: XAO:0000156
is_a: UBERON:0000990 ! reproductive system
intersection_of: UBERON:0000990 ! reproductive system
intersection_of: part_of UBERON:0003100 ! female organism
relationship: part_of UBERON:0003100 ! female organism
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/6/68/Scheme_female_reproductive_system-en.svg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "By far, sexual reproduction is the more common pattern among living vertebrate forms and its widespread occurrence suggests that it is the plesiomorphic, or primitive, reproductive mode among the vertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000726", ontology="VHOG", source="ISBN:978-0792383369 Lombardi J, Comparative vertebrate reproduction (1998) p.43", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000475
name: organism subdivision
namespace: uberon
def: "Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument." [CARO:0000032, CARO:DOS, http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: upper_level
synonym: "anatomic region" EXACT [MA:0002433]
synonym: "body part" RELATED []
synonym: "body region" RELATED [FMA:7153]
synonym: "cardinal body part" RELATED [FMA:7153]
xref: AAO:0010053
xref: AEO:0000032
xref: BILA:0000032
xref: BIRNLEX:7
xref: CALOHA:TS-2084
xref: CARO:0000032
xref: EFO:0000808
xref: EHDAA2:0003032
xref: EMAPA:36031
xref: FBbt:00007009 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7153
xref: galen:BodyPart
xref: HAO:0000032
xref: MA:0002433
xref: MAT:0000293
xref: MESH:D001829
xref: MIAA:0000293
xref: NCIT:C32221
xref: TAO:0001308
xref: TGMA:0001840
xref: UMLS:C0229962 {source="ncithesaurus:Body_Part"}
xref: VHOG:0001758
xref: Wikipedia:Body_part
xref: XAO:0003013
xref: ZFA:0001308
is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure
relationship: has_part UBERON:0000075 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! subdivision of skeletal system
relationship: has_part UBERON:0034929 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! external soft tissue zone
relationship: overlaps UBERON:0001009 {gci_filler="NCBITaxon:33213", gci_relation="in_taxon"} ! circulatory system
relationship: overlaps UBERON:0001015 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! musculature
relationship: overlaps UBERON:0001016 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! nervous system
relationship: overlaps UBERON:0001434 {gci_filler="NCBITaxon:33213", gci_relation="in_taxon"} ! skeletal system
relationship: overlaps UBERON:0002416 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! integumental system
relationship: part_of UBERON:0000468 ! multicellular organism
property_value: editor_note "Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency" xsd:string
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000476
name: acellular anatomical structure
namespace: uberon
def: "Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue." [http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: vertebrate_core
synonym: "acellular anatomical structures" RELATED OMO:0003004 [ZFA:0000382]
xref: AAO:0010268
xref: AEO:0000040
xref: BILA:0000040
xref: CARO:0000040
xref: EHDAA2:0003040
xref: FBbt:00007013 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:63863
xref: HAO:0000040
xref: TAO:0000382
xref: TGMA:0001841
xref: XAO:0003162
xref: ZFA:0000382
is_a: UBERON:0000061 ! anatomical structure
disjoint_from: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000477
name: anatomical cluster
namespace: uberon
def: "Anatomical group whose component anatomical structures lie in close proximity to each other." [FBbt:00007277]
subset: common_anatomy
subset: upper_level
xref: FBbt:00007277 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: VHOG:0001737
is_a: UBERON:0034923 ! disconnected anatomical group
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000478
name: extraembryonic structure
namespace: uberon
def: "A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis." [CARO:DOS, http://orcid.org/0000-0001-9114-8737, https://cedar.bio.indiana.edu/trac/env/ontologies/ticket/279]
comment: see also conceptus extraembryonic component in EHDAA2.
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "extra-embryonic structure" EXACT []
synonym: "extraembryonic structures" RELATED OMO:0003004 [ZFA:0000020]
synonym: "extraembryonic tissue" RELATED []
xref: AAO:0010020
xref: AEO:0000042
xref: BILA:0000042
xref: CALOHA:TS-2119
xref: CARO:0000042
xref: EHDAA2:0003042
xref: EHDAA:46
xref: FBbt:00005835 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:85537
xref: HAO:0000042
xref: NCIT:C34055
xref: SCTID:314908006
xref: TAO:0000020
xref: TGMA:0001843
xref: UMLS:C1282438 {source="ncithesaurus:Extraembryonic_Structure"}
xref: VHOG:0000292
xref: XAO:0004005
xref: ZFA:0000020
is_a: UBERON:0005423 ! developing anatomical structure
intersection_of: UBERON:0005423 ! developing anatomical structure
intersection_of: part_of UBERON:0016887 ! entire extraembryonic component
relationship: existence_starts_and_ends_during UBERON:0000068 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! embryo stage
relationship: part_of UBERON:0016887 ! entire extraembryonic component

[Term]
id: UBERON:0000479
name: tissue
namespace: uberon
def: "Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation." [CARO:0000043]
subset: common_anatomy
subset: pheno_slim
subset: upper_level
synonym: "portion of tissue" EXACT [CARO:0000043]
synonym: "simple tissue" NARROW [AEO:0000043]
synonym: "tissue portion" EXACT []
xref: AAO:0000607
xref: AAO:0010054
xref: AEO:0000043
xref: BILA:0000043
xref: BIRNLEX:19
xref: CALOHA:TS-2090
xref: CARO:0000043
xref: EHDAA2:0003043
xref: EMAPA:35868
xref: FBbt:00007003 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:9637
xref: galen:Tissue
xref: HAO:0000043
xref: MA:0003002
xref: MESH:D014024
xref: NCIT:C12801
xref: TAO:0001477
xref: TGMA:0001844
xref: UMLS:C0040300 {source="ncithesaurus:Tissue"}
xref: VHOG:0001757
xref: WBbt:0005729
xref: XAO:0003040
xref: ZFA:0001477
is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure
relationship: has_part GO:0031012 ! extracellular matrix
relationship: part_of UBERON:0000468 ! multicellular organism
property_value: editor_note "changed label and definition to reflect CARO2" xsd:string
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000481
name: multi-tissue structure
namespace: uberon
def: "Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types." [CARO:0000055, http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: upper_level
synonym: "multi-tissue structures" RELATED OMO:0003004 [ZFA:0001488]
xref: AAO:0010048
xref: AEO:0000055
xref: BILA:0000055
xref: CARO:0000055
xref: EHDAA2:0003055
xref: FBbt:00007010 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: HAO:0000055
xref: TAO:0001488
xref: TGMA:0001847
xref: VHOG:0001762
xref: XAO:0003037
xref: ZFA:0001488
is_a: UBERON:0010000 {source="CARO"} ! multicellular anatomical structure
relationship: has_part UBERON:0000479 ! tissue
relationship: part_of NCBITaxon:6072 {gci_filler="NCBITaxon:6072", gci_relation="in_taxon"} ! Eumetazoa
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0000483
name: epithelium
namespace: uberon
def: "Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Epithelium]
comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "epithelial tissue" EXACT []
synonym: "portion of epithelium" EXACT [FMA:9639]
xref: AAO:0000144
xref: AAO:0010055
xref: AEO:0000066
xref: BILA:0000066
xref: BTO:0000416
xref: CALOHA:TS-0288
xref: CARO:0000066
xref: EHDAA2:0003066
xref: EMAPA:32738
xref: FBbt:00007005 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:9639
xref: GAID:402
xref: HAO:0000066
xref: MA:0003060
xref: MESH:D004848
xref: NCIT:C12710
xref: SCTID:31610004
xref: TAO:0001486
xref: UMLS:C0014609 {source="ncithesaurus:Epithelium"}
xref: VHOG:0000387
xref: Wikipedia:Epithelium
xref: XAO:0003045
xref: ZFA:0001486
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: composed_primarily_of CL:0000066 ! epithelial cell
union_of: UBERON:0000486 ! multilaminar epithelium
union_of: UBERON:0000490 ! unilaminar epithelium
relationship: composed_primarily_of CL:0000066 ! epithelial cell
relationship: has_part GO:0005911 ! cell-cell junction
relationship: has_part UBERON:0005769 ! basement membrane of epithelium
relationship: only_in_taxon NCBITaxon:33208 {source="http://palaeos.com/metazoa/porifera/homoscleromorpha.html"} ! Metazoa
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000003 "The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000387", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epithelial" xsd:string

[Term]
id: UBERON:0000484
name: simple cuboidal epithelium
namespace: uberon
def: "Unilaminar epithelium that consists of a single layer of cuboidal cells." [http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_cuboidal_epithelium]
subset: uberon_slim
subset: vertebrate_core
synonym: "epithelium simplex cuboideum" EXACT []
synonym: "simple cuboidal epithelia" RELATED OMO:0003004 [ZFA:0001497]
xref: AAO:0010064
xref: AEO:0000067
xref: BILA:0000067
xref: CARO:0000067
xref: EHDAA2:0003067
xref: FMA:45566
xref: HAO:0000067
xref: NCIT:C33553
xref: TAO:0001497
xref: UMLS:C0836134 {source="ncithesaurus:Simple_Cuboidal_Epithelium"}
xref: Wikipedia:Simple_cuboidal_epithelium
xref: XAO:0004009
xref: ZFA:0001497
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0010077 ! cuboidal epithelium
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png" xsd:anyURI
property_value: editor_note "needs to be synchronized with CL - there is no distinct cuboidal cell in CL" xsd:string

[Term]
id: UBERON:0000485
name: simple columnar epithelium
namespace: uberon
def: "Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_columnar_epithelium]
subset: uberon_slim
subset: vertebrate_core
synonym: "columnar epithelium" BROAD [EHDAA2:0003068]
synonym: "columnar epithlium" BROAD [AEO:0000068]
synonym: "epithelium simplex columnare" EXACT []
synonym: "simple columnar epithelia" RELATED OMO:0003004 [ZFA:0001496]
synonym: "simple columnar epithelium" EXACT []
xref: AAO:0010063
xref: AEO:0000068
xref: BILA:0000068
xref: CARO:0000068
xref: EHDAA2_RETIRED:0003068
xref: FBbt:00007027 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45567
xref: HAO:0000068
xref: NCIT:C33552
xref: SCTID:32210007
xref: TAO:0001496
xref: UMLS:C0836135 {source="ncithesaurus:Simple_Columnar_Epithelium"}
xref: Wikipedia:Simple_columnar_epithelium
xref: XAO:0004008
xref: ZFA:0001496
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0012274 ! columnar epithelium
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray1059.png" xsd:anyURI

[Term]
id: UBERON:0000486
name: multilaminar epithelium
namespace: uberon
def: "Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]." [FMA:FMA, http://orcid.org/0000-0001-9114-8737, Wikipedia:Stratified_epithelium]
subset: uberon_slim
subset: vertebrate_core
synonym: "laminated epithelium" RELATED [BTO:0002074]
synonym: "stratified epithelium" EXACT []
xref: AAO:0010059
xref: AEO:0000069
xref: BILA:0000069
xref: BTO:0002074
xref: CARO:0000069
xref: EHDAA2:0003069
xref: FMA:45562
xref: HAO:0000069
xref: NCIT:C33622
xref: SCTID:309044005
xref: TAO:0001494
xref: UMLS:C0682575 {source="ncithesaurus:Stratified_Epithelium"}
xref: Wikipedia:Stratified_epithelium
xref: XAO:0004006
xref: ZFA:0001494
is_a: UBERON:0000483 ! epithelium
property_value: UBPROP:0000001 "Epithelium that consists of more than one layer of epithelial cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000069", ontology="CARO", source="FMA:45562", source="http://orcid.org/0000-0001-9114-8737"}

[Term]
id: UBERON:0000487
name: simple squamous epithelium
namespace: uberon
def: "Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]." [FMA:45565, http://orcid.org/0000-0001-9114-8737, Wikipedia:Simple_squamous_epithelium]
subset: uberon_slim
subset: vertebrate_core
synonym: "epithelium simplex squamosum" EXACT []
synonym: "simple squamous epithelia" RELATED OMO:0003004 [ZFA:0001498]
xref: AAO:0010066
xref: AEO:0000070
xref: BILA:0000070
xref: BTO:0002073
xref: CARO:0000070
xref: EHDAA2:0003070
xref: FMA:45565
xref: HAO:0000070
xref: NCIT:C13178
xref: TAO:0001498
xref: UMLS:C0836133 {source="ncithesaurus:Simple_Squamous_Epithelium"}
xref: Wikipedia:Simple_squamous_epithelium
xref: XAO:0004010
xref: ZFA:0001498
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0006914 ! squamous epithelium
intersection_of: UBERON:0000490 ! unilaminar epithelium
intersection_of: has_part CL:0000076 ! squamous epithelial cell
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/8/8f/Illu_epithelium.jpg" xsd:anyURI
property_value: UBPROP:0000001 "Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000070", ontology="CARO", source="FMA:45565", source="http://orcid.org/0000-0001-9114-8737"}

[Term]
id: UBERON:0000488
name: atypical epithelium
namespace: uberon
def: "Epithelium that consists of epithelial cells not arranged in one ore more layers." [http://orcid.org/0000-0001-9114-8737]
subset: vertebrate_core
synonym: "atypical epithelia" RELATED OMO:0003004 [ZFA:0001493]
synonym: "heterogenous epithelium" EXACT []
xref: AAO:0010057
xref: AEO:0000071
xref: BILA:0000071
xref: CARO:0000071
xref: EHDAA2:0003071
xref: FMA:61741
xref: HAO:0000071
xref: TAO:0001493
xref: XAO:0004004
xref: ZFA:0001493
is_a: UBERON:0000483 ! epithelium

[Term]
id: UBERON:0000489
name: cavitated compound organ
namespace: uberon
def: "Compound organ that contains one or more macroscopic anatomical spaces." [http://orcid.org/0000-0001-9114-8737]
subset: organ_slim
subset: upper_level
synonym: "cavitated compound organs" RELATED OMO:0003004 [ZFA:0001490]
synonym: "cavitated organ" EXACT [FMA:55671]
xref: AAO:0010016
xref: AEO:0000072
xref: BILA:0000072
xref: CARO:0000072
xref: EHDAA2:0003072
xref: FMA:55671
xref: HAO:0000072
xref: TAO:0001490
xref: TGMA:0001857
xref: VHOG:0001730
xref: XAO:0003165
xref: ZFA:0001490
is_a: UBERON:0003103 ! compound organ
intersection_of: UBERON:0003103 ! compound organ
intersection_of: has_part UBERON:0002553 ! anatomical cavity
relationship: has_part UBERON:0002553 ! anatomical cavity
property_value: curator_notes "this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future" xsd:string

[Term]
id: UBERON:0000490
name: unilaminar epithelium
namespace: uberon
def: "Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]." [FMA:45561, http://orcid.org/0000-0001-9114-8737]
subset: vertebrate_core
synonym: "simple epithelium" EXACT [FMA:45561]
synonym: "unilaminar epithelia" RELATED OMO:0003004 [ZFA:0001495]
xref: AAO:0010062
xref: AEO:0000073
xref: BILA:0000073
xref: BTO:0002073
xref: CARO:0000073
xref: EHDAA2:0003073
xref: FMA:45561
xref: HAO:0000073
xref: NCIT:C33554
xref: SCTID:309043004
xref: TAO:0001495
xref: UMLS:C0682574 {source="ncithesaurus:Simple_Epithelium"}
xref: XAO:0004007
xref: ZFA:0001495
is_a: UBERON:0000483 ! epithelium
property_value: editor_note "consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable" xsd:string
property_value: UBPROP:0000001 "Epithelium that consists of a single layer of epithelial cells.[CARO]" xsd:string {date_retrieved="2012-06-20", external_class="CARO:0000073", ontology="CARO", source="FMA:45561", source="http://orcid.org/0000-0001-9114-8737"}

[Term]
id: UBERON:0000912
name: mucus
namespace: uberon
def: "Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water." [Wikipedia:Mucus]
xref: CALOHA:TS-2144
xref: ENVO:02000040
xref: FMA:66938
xref: GAID:1164
xref: galen:Mucus
xref: MESH:D009093
xref: NCIT:C13259
xref: UMLS:C0026727 {source="ncithesaurus:Mucus"}
xref: Wikipedia:Mucus
is_a: UBERON:0000456 ! secretion of exocrine gland
is_a: UBERON:0006314 ! bodily fluid
relationship: has_part CHEBI:37395 ! mucopolysaccharide
relationship: has_quality PATO:0000998 ! viscous
relationship: produced_by UBERON:0000344 ! mucosa
property_value: UBPROP:0000007 "mucoid" xsd:string
property_value: UBPROP:0000007 "mucous" xsd:string

[Term]
id: UBERON:0000915
name: thoracic segment of trunk
namespace: uberon
def: "Subdivision of trunk that lies between the head and the abdomen." [http://orcid.org/0000-0002-6601-2165]
subset: uberon_slim
synonym: "anterior subdivision of trunk" RELATED []
synonym: "thorax" EXACT [MA:0000022]
synonym: "upper body" RELATED []
synonym: "upper trunk" RELATED [FMA:259209]
xref: EMAPA:35862
xref: FMA:259209
xref: MA:0000022
xref: SCTID:302551006
xref: Wikipedia:Thorax
is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis
intersection_of: UBERON:0011676 ! subdivision of organism along main body axis
intersection_of: has_skeleton UBERON:0014477 ! thoracic skeleton
relationship: has_skeleton UBERON:0014477 ! thoracic skeleton
property_value: curator_notes "note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest" xsd:string
property_value: RO:0002171 UBERON:0000026
property_value: RO:0002171 UBERON:0000033
property_value: RO:0002171 UBERON:0002417

[Term]
id: UBERON:0000916
name: abdomen
namespace: uberon
def: "The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column." [http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "abdominopelvic region" EXACT [FMA:9577]
synonym: "abdominopelvis" EXACT [FMA:9577]
synonym: "adult abdomen" RELATED []
synonym: "belly" RELATED []
synonym: "celiac region" RELATED []
xref: BTO:0000020
xref: CALOHA:TS-0001
xref: EFO:0000968
xref: EMAPA:35102
xref: EV:0100011
xref: FMA:9577
xref: GAID:16
xref: galen:Abdomen
xref: MA:0000029
xref: MAT:0000298
xref: MESH:D000005
xref: MIAA:0000298
xref: SCTID:302553009
xref: Wikipedia:Abdomen
is_a: UBERON:0009569 ! subdivision of trunk
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0002417 {source="MA"} ! abdominal segment of trunk
property_value: editor_note "Vertebrate specific. In arthropods 'abdomen' is the most distal section of the body which lies behind the thorax or cephalothorax. If need be we can introduce some grouping class" xsd:string
property_value: UBPROP:0000007 "abdominal" xsd:string
property_value: UBPROP:0000007 "celiac" xsd:string

[Term]
id: UBERON:0000922
name: embryo
namespace: uberon
def: "Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [BTO:0000379, FB:FBrf0039741, FB:FBrf0041814, GO:0009790, Wikipedia:Embryo]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "developing organism" RELATED [BILA:0000056]
synonym: "developmental tissue" RELATED []
synonym: "embryonic organism" EXACT [BILA:0000056]
xref: AAO:0011035
xref: AEO:0000169
xref: BILA:0000056
xref: BSA:0000039
xref: BTO:0000379
xref: CALOHA:TS-0229
xref: EFO:0001367
xref: EHDAA2:0000002
xref: EHDAA2_RETIRED:0003236
xref: EHDAA:38
xref: EMAPA:16039
xref: FBbt:00000052 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:69068
xref: GAID:963
xref: http://neurolex.org/wiki/Category\:Embryonic_organism
xref: IDOMAL:0000646 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0003-4423-4370", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: MAT:0000226
xref: MESH:D004622
xref: MIAA:0000019
xref: NCIT:C28147
xref: OGEM:000001
xref: SCTID:57991002
xref: UMLS:C0013935 {source="ncithesaurus:Embryo"}
xref: VHOG:0001766
xref: Wikipedia:Embryo
xref: XAO:0000113
xref: ZFA:0000103
is_a: UBERON:0000468 ! multicellular organism
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_ends_with UBERON:0000068 ! embryo stage
intersection_of: existence_starts_with UBERON:0000068 ! embryo stage
relationship: existence_ends_with UBERON:0000068 ! embryo stage
relationship: existence_starts_with UBERON:0000068 ! embryo stage
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/2/2d/Wrinkledfrog_embryos.jpg" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/503" xsd:anyURI
property_value: UBPROP:0000007 "embryonic" xsd:string
property_value: UBPROP:0000012 "Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo" xsd:string {external_ontology="ZFA"}

[Term]
id: UBERON:0000923
name: germ layer
namespace: uberon
def: "A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm." [https://github.com/obophenotype/uberon/issues/203, Wikipedia:Germ_layer]
comment: Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest]
subset: uberon_slim
subset: vertebrate_core
synonym: "embryonic germ layer" RELATED []
synonym: "embryonic germ layers" RELATED []
synonym: "embryonic tissue" BROAD [FMA:69069]
synonym: "germinal layer" EXACT [ncithesaurus:Germinal_Layer]
synonym: "primary germ layer" NARROW [GO:0001704, ZFA:0001122]
xref: AAO:0000480
xref: BILA:0000035
xref: BTO:0000556
xref: EMAPA:36033
xref: FBbt:00000110 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:69069
xref: GAID:1303
xref: MESH:D005855
xref: NCIT:C12950
xref: NCIT:C54105
xref: TAO:0001122
xref: UMLS:C0920502 {source="ncithesaurus:Embryonic_Tissue"}
xref: UMLS:C1708239 {source="ncithesaurus:Germinal_Layer"}
xref: VHOG:0001223
xref: Wikipedia:Germ_layer
xref: XAO:0003011
xref: ZFA:0001122
is_a: UBERON:0010316 ! germ layer / neural crest
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001223", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000924
name: ectoderm
namespace: uberon
def: "Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue." [Wikipedia:Ectoderm]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "embryonic ectoderm" EXACT [VHOG:0000153]
xref: AAO:0000137
xref: BILA:0000036
xref: BTO:0000315
xref: CALOHA:TS-0216
xref: EFO:0000414
xref: EHDAA2:0000428
xref: EMAPA:16069
xref: EV:0100003
xref: FBbt:00000111 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:69070
xref: GAID:1304
xref: MAT:0000155
xref: MAT:0000173
xref: MESH:D004475
xref: MIAA:0000173
xref: NCIT:C12703
xref: SCTID:362851007
xref: TAO:0000016
xref: UMLS:C0013574 {source="ncithesaurus:Ectoderm"}
xref: VHOG:0000153
xref: Wikipedia:Ectoderm
xref: XAO:0000001
xref: ZFA:0000016
is_a: UBERON:0000923 ! germ layer
relationship: develops_from UBERON:0006601 ! presumptive ectoderm
relationship: has_part CL:0000221 ! ectodermal cell
relationship: immediate_transformation_of UBERON:0006601 {source="Bgee:AN"} ! presumptive ectoderm
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png" xsd:anyURI
property_value: UBPROP:0000001 "Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000137", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000153", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ectodermal" xsd:string

[Term]
id: UBERON:0000925
name: endoderm
namespace: uberon
def: "Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut." [Wikipedia:Endoderm]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "entoderm" RELATED DEPRECATED [DOI:10.5962/bhl.title.1013]
xref: AAO:0000139
xref: BILA:0000038
xref: BTO:0000800
xref: CALOHA:TS-0273
xref: EFO:0002545
xref: EHDAA2:0000436
xref: EMAPA:16062
xref: EV:0100005
xref: FBbt:00000125 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:69071
xref: GAID:1305
xref: MAT:0000175
xref: MESH:D004707
xref: MIAA:0000175
xref: NCIT:C12706
xref: SCTID:362855003
xref: TAO:0000017
xref: UMLS:C0014144 {source="ncithesaurus:Endoderm"}
xref: VHOG:0000154
xref: Wikipedia:Endoderm
xref: XAO:0000090
xref: ZFA:0000017
is_a: UBERON:0000923 ! germ layer
relationship: develops_from UBERON:0006595 ! presumptive endoderm
relationship: has_part CL:0000223 ! endodermal cell
relationship: immediate_transformation_of UBERON:0006595 {source="Bgee:AN"} ! presumptive endoderm
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png" xsd:anyURI
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000154", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endodermal" xsd:string

[Term]
id: UBERON:0000926
name: mesoderm
namespace: uberon
alt_id: UBERON:0003263
def: "The middle germ layer of the embryo, between the endoderm and ectoderm." [Wikipedia:Mesoderm]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "embryonic mesoderm" RELATED [VHOG:0000152]
synonym: "entire mesoderm" RELATED [https://orcid.org/0000-0002-6601-2165, SCTID:362854004]
synonym: "mesodermal mantle" RELATED []
xref: AAO:0000304
xref: BILA:0000037
xref: BTO:0000839
xref: CALOHA:TS-0623
xref: EFO:0001981
xref: EHDAA2:0001128
xref: EHDAA:124
xref: EHDAA:160
xref: EHDAA:183
xref: EMAPA:16083
xref: EV:0100006
xref: FBbt:00000126 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:69072
xref: GAID:522
xref: MAT:0000174
xref: MESH:D008648
xref: MIAA:0000174
xref: NCIT:C12750
xref: SCTID:362854004
xref: TAO:0000041
xref: UMLS:C0025485 {source="ncithesaurus:Mesoderm"}
xref: VHOG:0000152
xref: Wikipedia:Mesoderm
xref: XAO:0000050
xref: ZFA:0000041
is_a: UBERON:0000923 {notes="sometimes not considered primary"} ! germ layer
relationship: develops_from UBERON:0006603 ! presumptive mesoderm
relationship: has_part CL:0000222 ! mesodermal cell
relationship: immediate_transformation_of UBERON:0006603 {source="Bgee:AN"} ! presumptive mesoderm
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png" xsd:anyURI
property_value: RO:0002161 NCBITaxon:6040
property_value: UBPROP:0000001 "Primary germ layer that is the middle of the embryonic germ layers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000304", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000152", ontology="VHOG", source="ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "mesodermal" xsd:string
property_value: UBPROP:0000008 "sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates" xsd:string {source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"}

[Term]
id: UBERON:0000930
name: stomodeum
namespace: uberon
def: "Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity." [http://orcid.org/0000-0002-6601-2165, https://github.com/obophenotype/uberon/issues/326, Wikipedia:Stomodeum]
subset: grouping_class
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "mouth pit" RELATED [EMAPA:16263]
synonym: "mouth primordium" EXACT [XAO:0000269]
synonym: "oral ectoderm" RELATED [ZFA:0001290, ZFIN:ZDB-PUB-100726-23]
synonym: "oral pit" RELATED [EMAPA:16263]
synonym: "primitive oral cavity" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "stomatodeum" EXACT [Wikipedia:Stomodeum]
synonym: "stomodaeum" EXACT []
synonym: "stomodeal-hypophyseal primordium" BROAD [XAO:0000269]
xref: BTO:0004224
xref: EHDAA2:0001929
xref: EMAPA:16263
xref: FBbt:00000439 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:295846
xref: NCIT:C34306
xref: TAO:0001290
xref: TGMA:0000135
xref: UMLS:C1514977 {source="ncithesaurus:Stomodeum"}
xref: Wikipedia:Stomodeum
xref: XAO:0000269
xref: ZFA:0001290
is_a: UBERON:0013522 ! subdivision of tube
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000924 ! ectoderm
relationship: part_of UBERON:0035804 ! future mouth
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png" xsd:anyURI
property_value: editor_note "consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence" xsd:string
property_value: UBPROP:0000001 "Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001290", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx" xsd:string {source="MP:0012522", taxon="NCBITaxon:40674"}
property_value: UBPROP:0000007 "stomodeal" xsd:string
property_value: UBPROP:0000008 "This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity." xsd:string

[Term]
id: UBERON:0000931
name: proctodeum
namespace: uberon
def: "Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract." [https://github.com/obophenotype/uberon/issues/685, https://sourceforge.net/p/fbbtdv/tickets/52, ZFA:0000066]
subset: uberon_slim
synonym: "amnioproctodeal invagination" NARROW [FBbt:00000123]
synonym: "anal pit" RELATED [VHOG:0000139]
synonym: "anus porus" RELATED [XAO:0001019]
synonym: "embryonic proctodaeum" EXACT []
synonym: "proctodaeum" EXACT []
xref: AAO:0011087
xref: EHDAA2:0000121
xref: EMAPA:25038
xref: FBbt:00000123 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: NCIT:C34278
xref: TAO:0000066
xref: UMLS:C0231054 {source="ncithesaurus:Proctodeum"}
xref: VHOG:0000139
xref: Wikipedia:Proctodeum
xref: XAO:0001019
xref: ZFA:0000066
is_a: UBERON:0016566 {source="EHDAA2"} ! pit
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: has_potential_to_develop_into UBERON:0001353 ! anal region
relationship: located_in UBERON:0012469 {source="EHDAA2"} ! external anal region
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0007026 ! presumptive gut
property_value: editor_note "removed WBbt:0006795 'proctodeum' - junction between the alimentary and genital tracts in the male." xsd:string
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/685" xsd:anyURI
property_value: UBPROP:0000001 "An inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000066", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Inward fold on the surface of the embryonic ectoderm that develops into part of the anal passage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0011087", ontology="AAO", source="ZFA:0000066"}
property_value: UBPROP:0000007 "proctodeal" xsd:string
property_value: x_1.1:contributor https://github.com/ANiknejad
property_value: x_1.1:contributor https://github.com/cmungall
property_value: x_1.1:contributor https://github.com/dosumis
property_value: x_1.1:contributor https://github.com/mmc46

[Term]
id: UBERON:0000945
name: stomach
namespace: uberon
def: "An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium." [https://orcid.org/0000-0002-6601-2165, ISBN:0073040584, Wikipedia:Stomach]
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "anterior intestine" RELATED []
synonym: "gaster" RELATED [BTO:0001307]
synonym: "mesenteron" RELATED []
synonym: "stomach chamber" NARROW []
synonym: "ventriculus" RELATED OMO:0003011 [Wikipedia:Stomach]
xref: AAO:0000579
xref: ANISEED:1235297
xref: BTO:0001307
xref: CALOHA:TS-0980
xref: EFO:0000837
xref: EHDAA2:0001915
xref: EHDAA:2993
xref: EMAPA:17021
xref: EV:0100070
xref: FMA:7148
xref: GAID:293
xref: galen:Stomach
xref: MA:0000353
xref: MAT:0000051
xref: MESH:D013270
xref: MIAA:0000051
xref: NCIT:C12391
xref: SCTID:181246003
xref: TAO:0002121
xref: UMLS:C0038351 {source="ncithesaurus:Stomach"}
xref: VHOG:0000408
xref: Wikipedia:Stomach
xref: XAO:0000128
is_a: UBERON:0004921 {source="cjm"} ! subdivision of digestive tract
is_a: UBERON:0010039 {source="cjm"} ! food storage organ
relationship: capable_of GO:0001696 {evidence="ISBN:0486692132"} ! gastric acid secretion
relationship: contributes_to_morphology_of UBERON:0001007 ! digestive system
relationship: only_in_taxon NCBITaxon:7776 {notes="absent in lampreys and hagfishes", source="ISBN:0073040584"} ! Gnathostomata <vertebrates>
relationship: part_of UBERON:0001041 ! foregut
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/e/e0/Stomach_diagram.svg" xsd:anyURI
property_value: RO:0002161 NCBITaxon:7864 {source="Wikipedia"}
property_value: RO:0002161 NCBITaxon:7878 {source="Wikipedia"}
property_value: RO:0002161 NCBITaxon:7955 {source="ZFA"}
property_value: RO:0002161 NCBITaxon:9259 {source="Wikipedia"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Portion of alimentary canal with increased circular and longitudinal smooth muscle. Bounded posteriorly by the pyloric sphincter. Mucosal lining has increased folding.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000579", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "It appears that the stomach has an ancient origin. The stomach first appears in the fish lineage. The prevertebrate chordates do not have a true stomach, whereas the cartilaginous and bony fish do. Although most fish do have a true stomach, some fish species appear to have lost the stomach secondarily. The remaining vertebrate lineages do have a true stomach (at least in the adult animal), although there is great variation in the size and shape of the stomach.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000408", ontology="VHOG", source="DOI:10.1046/j.1525-142x.2000.00076.x Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM, Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evolution and development (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "We restrict this to the vertebrate specific structure - see the grouping class 'food storage organ' for analogous structures in other species. Teleosts: Zebrafish is functionally stomach-less, but may retain ontogenic footprint. Although the precise shape and size of the stomach varies widely among different vertebrates, the relative positions of the oesophageal and duodenal openings remain relatively constant. As a result, the organ always curves somewhat to the left before curving back to meet the pyloric sphincter. However, lampreys, hagfishes, chimaeras, lungfishes, and some teleost fish have no stomach at all, with the oesophagus opening directly into the intestine. The gastric lining is usually divided into two regions, an anterior portion lined by fundic glands, and a posterior with pyloric glands. Cardiac glands are unique to mammals, and even then are absent in a number of species. The distributions of these glands vary between species, and do not always correspond with the same regions as in man. Furthermore, in many non-human mammals, a portion of the stomach anterior to the cardiac glands is lined with epithelium essentially identical to that of the oesophagus. Ruminants, in particular, have a complex stomach, the first three chambers of which are all lined with oesophageal mucosa" xsd:string {source="WP:Stomach#In_other_animals"}

[Term]
id: UBERON:0000947
name: aorta
namespace: uberon
def: "The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MESH:A07.231.114.056, MP:0000272, Wikipedia:Aorta]
subset: efo_slim
subset: grouping_class
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "arteria maxima" RELATED OMO:0003011 [Wikipedia:Aorta]
synonym: "dorsal aorta" NARROW SENSU [Wikipedia:Aorta#In_other_animals, ZFA:0000014]
synonym: "trunk of aortic tree" EXACT []
synonym: "trunk of systemic arterial tree" EXACT []
xref: AAO:0010213
xref: BTO:0000135
xref: CALOHA:TS-0046
xref: EFO:0000265
xref: EMAPA:18601
xref: EV:0100027
xref: FMA:3734
xref: GAID:469
xref: galen:Aorta
xref: MA:0000062
xref: MAT:0000035
xref: MESH:D001011
xref: MIAA:0000035
xref: NCIT:C12669
xref: SCTID:181298001
xref: UMLS:C0003483 {source="ncithesaurus:Aorta"}
xref: VHOG:0001523
xref: Wikipedia:Aorta
xref: XAO:0003010
is_a: UBERON:0003509 {source="MA"} ! arterial blood vessel
is_a: UBERON:0003519 ! thoracic cavity blood vessel
is_a: UBERON:0013768 ! great vessel of heart
relationship: connected_to UBERON:0002084 ! heart left ventricle
relationship: part_of RO:0002577 ! system
relationship: part_of UBERON:0010191 {source="EHDAA2"} ! aortic system
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Blood_Vasculature.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Blood_Vasculature.glb" xsd:anyURI
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/9/91/Aorta_scheme.jpg" xsd:anyURI
property_value: editor_note "This class is currently a mixed bag, encompassing (1) the entirety of the mammalian aorta together with (2) the developmental and phylogenetic homologs of its segments: the ventral aorta and dorsal aortae." xsd:string {source="WP"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The main artery of the circulatory system which carries oxygenated blood from the heart to all the arteries of the body except those of the lungs.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010213", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "When vertebrates first appeared, they must have possessed a ventral and dorsal aorta with aortic arches between them.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001523", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "aortic" xsd:string
property_value: UBPROP:0000008 "All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body, and is homologous with the descending aorta of tetrapods. The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches" xsd:string

[Term]
id: UBERON:0000948
name: heart
namespace: uberon
def: "A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Heart]
comment: Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "branchial heart" NARROW SENSU []
synonym: "cardium" RELATED [EMAPA:16105]
synonym: "chambered heart" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "vertebrate heart" EXACT []
xref: AAO:0010210
xref: BILA:0000020
xref: BTO:0000562
xref: CALOHA:TS-0445
xref: EFO:0000815
xref: EHDAA2:0000738
xref: EHDAA:420
xref: EMAPA:16105
xref: EV:0100018
xref: FMA:7088
xref: GAID:174
xref: galen:Heart
xref: MA:0000072
xref: MAT:0000036
xref: MESH:D006321
xref: MIAA:0000036
xref: NCIT:C12727
xref: SCTID:302509004
xref: TAO:0000114
xref: UMLS:C0018787 {source="ncithesaurus:Heart"}
xref: VHOG:0000276
xref: Wikipedia:Heart
xref: XAO:0000064
xref: ZFA:0000114
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005181 ! thoracic segment organ
is_a: UBERON:0007100 ! primary circulatory organ
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0007100 ! primary circulatory organ
intersection_of: has_part UBERON:0004151 ! cardiac chamber
relationship: contributes_to_morphology_of UBERON:0004535 ! cardiovascular system
relationship: develops_from UBERON:0004141 ! heart tube
relationship: has_part UBERON:0004151 ! cardiac chamber
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0015410 {source="MA"} ! heart plus pericardium
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Heart.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Heart.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Heart.glb" xsd:anyURI
property_value: RO:0002161 NCBITaxon:6239
property_value: RO:0002161 NCBITaxon:7227
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000114", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000002 "relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010210", ontology="AAO"}
property_value: UBPROP:0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000276", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "cardiac" xsd:string

[Term]
id: UBERON:0000949
name: endocrine system
namespace: uberon
def: "Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity." [NLM:endocrine+system, Wikipedia:Endocrine_system]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "endocrine glandular system" EXACT [EHDAA2:0002224]
synonym: "endocrine system" EXACT []
synonym: "systema endocrinum" EXACT []
xref: AAO:0010279
xref: CALOHA:TS-1301
xref: EFO:0002969
xref: EHDAA2:0002224
xref: EMAPA:35306
xref: EV:0100128
xref: FBbt:00005068 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:9668
xref: GAID:439
xref: MA:0000012
xref: MESH:D004703
xref: NCIT:C12705
xref: SCTID:278876000
xref: TAO:0001158
xref: UMLS:C0014136 {source="ncithesaurus:Endocrine_System"}
xref: VHOG:0000098
xref: Wikipedia:Endocrine_system
xref: XAO:0000158
xref: ZFA:0001158
is_a: UBERON:0015204 ! glandular system
disjoint_from: UBERON:0000990 ! reproductive system
disjoint_from: UBERON:0001004 ! respiratory system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: composed_primarily_of UBERON:0002368 ! endocrine gland
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: UBPROP:0000001 "Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010279", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000098", ontology="VHOG", source="DOI:10.1073/pnas.0812138106 Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V, Independent elaboration of steroid hormone signaling pathways in metazoans. PNAS (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "endocrine" xsd:string

[Term]
id: UBERON:0000955
name: brain
namespace: uberon
def: "The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]." [https://github.com/obophenotype/uberon/issues/300, Wikipedia:Brain]
subset: cumbo
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "encephalon" RELATED [BTO:0000142]
synonym: "suprasegmental levels of nervous system" RELATED [NeuroNames:21]
synonym: "suprasegmental structures" RELATED [NeuroNames:21]
synonym: "synganglion" RELATED []
synonym: "the brain" RELATED [NeuroNames:21]
xref: AAO:0010478
xref: ABA:Brain
xref: BAMS:Br
xref: BAMS:Brain
xref: BILA:0000135
xref: BIRNLEX:796
xref: BTO:0000142
xref: CALOHA:TS-0095
xref: DHBA:10155
xref: EFO:0000302
xref: EHDAA2:0000183
xref: EHDAA:2641
xref: EHDAA:6485
xref: EMAPA:16894
xref: EV:0100164
xref: FBbt:00005095 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:50801
xref: GAID:571
xref: galen:Brain
xref: HBA:4005
xref: MA:0000168
xref: MAT:0000098
xref: MBA:8
xref: MBA:997
xref: MESH:D001921
xref: MIAA:0000098
xref: NCIT:C12439
xref: neuronames:21 {source="BIRNLEX:796"}
xref: PBA:3999
xref: SCTID:258335003
xref: TAO:0000008
xref: UMLS:C0006104 {source="ncithesaurus:Brain", source="BIRNLEX:796"}
xref: UMLS:C1269537 {source="BIRNLEX:796"}
xref: VHOG:0000157
xref: Wikipedia:Brain
xref: XAO:0000010
xref: ZFA:0000008
is_a: UBERON:0000062 {source="GO"} ! organ
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: capable_of GO:0050890 {gci_relation="part_of", gci_filler="NCBITaxon:9606"} ! cognition
relationship: composed_primarily_of CL:0002319 ! neural cell
relationship: contributes_to_morphology_of UBERON:0001016 ! nervous system
relationship: develops_from UBERON:0001049 {gci_relation="part_of", gci_filler="NCBITaxon:7711"} ! neural tube
relationship: develops_from UBERON:0006238 ! future brain
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: immediate_transformation_of UBERON:0006238 {source="Bgee:AN"} ! future brain
relationship: in_anterior_side_of UBERON:0000468 ! multicellular organism
relationship: part_of UBERON:0001017 {source="FMA"} ! central nervous system
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_F_Brain.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/Allen_M_Brain.glb" xsd:anyURI
property_value: editor_note "requires review for applicability to invertebrate structures, e.g. synganglion" xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000008", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010478", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)" xsd:string {source="http://neurolex.org/wiki/Cumbo_terms"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000157", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165", source="http://bgee.unil.ch/"}
property_value: x_1.1:contributor https://github.com/cmungall

[Term]
id: UBERON:0000957
name: lamina
namespace: uberon
def: "Any thin layer or plate." [Wikipedia:Lamina_of_the_vertebral_arch]
subset: non_informative
subset: uberon_slim
subset: upper_level
synonym: "laminar tissue" EXACT []
xref: Wikipedia:Lamina_of_the_vertebral_arch
is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: has_quality PATO:0002124 ! laminar
relationship: has_quality PATO:0002124 ! laminar
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/8/80/Laminaarcusvertebrae.png" xsd:anyURI
property_value: editor_note "TODO - merge with cell layer?" xsd:string
property_value: UBPROP:0000007 "laminar" xsd:string

[Term]
id: UBERON:0000962
name: nerve of cervical vertebra
namespace: uberon
def: "The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]." [Wikipedia:Cervical_nerves]
comment: Innervates: sternohyoid muscle, sternothyroid muscle, omohyoid muscle[WP]
subset: uberon_slim
synonym: "cervical nerve" EXACT [FMA:5859]
synonym: "cervical nerve tree" EXACT []
synonym: "cervical spinal nerve" EXACT []
synonym: "nervus cervicalis" EXACT OMO:0003011 [FMA:5859, FMA:TA]
xref: BAMS:cern
xref: FMA:5859
xref: NCIT:C32299
xref: neuronames:2351
xref: NLXANAT:20090207
xref: SCTID:360497008
xref: UMLS:C0228815 {source="ncithesaurus:Cervical_Nerve"}
xref: Wikipedia:Cervical_nerves
is_a: UBERON:0001780 ! spinal nerve
intersection_of: UBERON:0001780 ! spinal nerve
intersection_of: extends_fibers_into UBERON:0002726 ! cervical spinal cord
relationship: extends_fibers_into UBERON:0002726 ! cervical spinal cord
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/e6/Gray795.png" xsd:anyURI

[Term]
id: UBERON:0000963
name: head sensillum
namespace: uberon
xref: FBbt:00004114 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: MAT:0000204
xref: MIAA:0000204
is_a: UBERON:0002536 ! arthropod sensillum
intersection_of: UBERON:0002536 ! arthropod sensillum
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head
property_value: editor_note "this term should be ceded to the arthropod anatomy ontology" xsd:string

[Term]
id: UBERON:0000964
name: cornea
namespace: uberon
def: "The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure." [ISBN:0-683-40008-8, MESH:A09.371.060.217, MP:0001312]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "cornea of camera-type eye" EXACT [GO:0061303]
synonym: "corneas" RELATED OMO:0003004 [ZFA:0000640]
synonym: "tunica cornea" RELATED []
xref: AAO:0010344
xref: BTO:0000286
xref: CALOHA:TS-0171
xref: EFO:0000377
xref: EHDAA2:0000316
xref: EHDAA:10199
xref: EMAPA:17161
xref: EV:0100341
xref: FMA:58238
xref: GAID:892
xref: MA:0000266
xref: MESH:D003315
xref: NCIT:C12342
xref: SCTID:181162001
xref: TAO:0000640
xref: UMLS:C0010031 {source="ncithesaurus:Cornea"}
xref: VHOG:0000164
xref: Wikipedia:Cornea
xref: XAO:0000180
xref: ZFA:0000640
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0010000 ! multicellular anatomical structure
is_a: UBERON:0010313 ! neural crest-derived structure
relationship: continuous_with UBERON:0001773 ! sclera
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: developmentally_induced_by UBERON:0005426 ! lens vesicle
relationship: develops_from UBERON:0004348 {evidence="definitional"} ! optic eminence
relationship: develops_from UBERON:0005427 ! corneal primordium
relationship: has_part UBERON:0001772 ! corneal epithelium
relationship: has_part UBERON:0004370 ! anterior limiting lamina of cornea
relationship: has_quality PATO:0000964 ! transparent
relationship: part_of UBERON:0001801 {source="MA"} ! anterior segment of eyeball
relationship: part_of UBERON:0010409 {source="MA"} ! ocular surface region
relationship: part_of UBERON:0012430 {source="FMA-isa"} ! tunica fibrosa of eyeball
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000007 "corneal" xsd:string
property_value: UBPROP:0000008 "Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water" xsd:string

[Term]
id: UBERON:0000965
name: lens of camera-type eye
namespace: uberon
def: "A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Lens_(anatomy)]
comment: The lens is avascular and nourished by diffusion from the aqueous and vitreous humors.
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "camera-type eye lens" EXACT [GO:0002088]
synonym: "crystalline lens" RELATED [BTO:0000723, PMID:36055924]
synonym: "eye lens" EXACT SENSU []
synonym: "lens" EXACT SENSU []
synonym: "lens crystallina" EXACT [Wikipedia:Lens_(anatomy)]
synonym: "lenses" RELATED OMO:0003004 [ZFA:0000035]
synonym: "ocular lens" RELATED [BTO:0000723]
xref: AAO:0010348
xref: BTO:0000723
xref: CALOHA:TS-0545
xref: EHDAA:9057
xref: EMAPA:17838
xref: EV:0100343
xref: FMA:58241
xref: MA:0000275
xref: MAT:0000141
xref: MESH:D007908
xref: MIAA:0000141
xref: NCIT:C12743
xref: RETIRED_EHDAA2:0000975
xref: SCTID:181169005
xref: TAO:0000035
xref: UMLS:C0023317 {source="ncithesaurus:Crystalline_Lens"}
xref: VHOG:0000169
xref: Wikipedia:Lens_(anatomy)
xref: XAO:0000008
xref: ZFA:0000035
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005389 ! transparent eye structure
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: developmentally_induced_by UBERON:0003902 ! retinal neural layer
relationship: develops_from UBERON:0005426 ! lens vesicle
relationship: part_of UBERON:0001801 ! anterior segment of eyeball
property_value: RO:0002171 UBERON:0002049
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000169", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "This class excludes compound eye corneal lenses." xsd:string

[Term]
id: UBERON:0000966
name: retina
namespace: uberon
def: "The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [Wikipedia:Retina, ZFIN:curator]
comment: Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "inner layer of eyeball" EXACT []
synonym: "Netzhaut" RELATED [BTO:0001175]
synonym: "retina of camera-type eye" EXACT [GO:0060041]
synonym: "retinas" RELATED OMO:0003004 [ZFA:0000152]
synonym: "tunica interna of eyeball" EXACT []
xref: AAO:0010352
xref: BAMS:R
xref: BIRNLEX:1153
xref: BTO:0001175
xref: CALOHA:TS-0865
xref: EFO:0000832
xref: EHDAA2:0001627
xref: EHDAA:4757
xref: EMAPA:17168
xref: EV:0100348
xref: FMA:58301
xref: GAID:755
xref: MA:0000276
xref: MAT:0000142
xref: MBA:304325711
xref: MESH:D012160
xref: MIAA:0000142
xref: NCIT:C12343
xref: neuronames:1862
xref: NIFSTD_RETIRED:birnlex_1156
xref: SCTID:181171005
xref: TAO:0000152
xref: UMLS:C0035298 {source="BIRNLEX:1153", source="ncithesaurus:Retina"}
xref: UMLS:C1278894 {source="BIRNLEX:1153"}
xref: VHOG:0000229
xref: Wikipedia:Retina
xref: XAO:0000009
xref: ZFA:0000152
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0005388 ! photoreceptor array
relationship: develops_from UBERON:0003072 {source="EHDAA2"} ! optic cup
relationship: has_part CL:0000573 {source="FMA"} ! retinal cone cell
relationship: has_part CL:0000604 {source="FMA"} ! retinal rod cell
relationship: has_part CL:0000740 {source="FMA"} ! retinal ganglion cell
relationship: part_of UBERON:0001802 ! posterior segment of eyeball
relationship: part_of UBERON:0019207 ! chorioretinal region
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png" xsd:anyURI
property_value: RO:0002161 NCBITaxon:6656
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000152", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000229", ontology="VHOG", source="DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "retinal" xsd:string

[Term]
id: UBERON:0000970
name: eye
namespace: uberon
def: "An organ that detects light." [https://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: functional_classification
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: uberon_slim
synonym: "light-detecting organ" RELATED []
synonym: "visual apparatus" RELATED [EV:0100336]
xref: BILA:0000017
xref: BTO:0000439
xref: CALOHA:TS-0309
xref: EFO:0000827
xref: EV:0100336
xref: FBbt:00005162 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: GAID:69
xref: MAT:0000140
xref: MESH:D005123
xref: MIAA:0000140
xref: Wikipedia:Eye
is_a: UBERON:0000020 ! sense organ
relationship: capable_of GO:0009584 ! detection of visible light
relationship: has_part CL:0000149 {source="PMID:21062451"} ! visual pigment cell
relationship: has_part CL:0000210 {source="PMID:21062451"} ! photoreceptor cell
relationship: part_of UBERON:0002104 ! visual system
property_value: curator_notes "This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each)" xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000007 "ocular" xsd:string
property_value: UBPROP:0000007 "optic" xsd:string
property_value: UBPROP:0000010 "Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva," xsd:string

[Term]
id: UBERON:0000971
name: ommatidium
namespace: uberon
def: "The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells." [PMID:21062451]
subset: uberon_slim
synonym: "omatidia" RELATED OMO:0003004 []
synonym: "omatidium" EXACT []
xref: BTO:0001922
xref: FBbt:00004510 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: HAO:0000666
xref: MAT:0000143
xref: MIAA:0000143
xref: Wikipedia:Ommatidium
is_a: UBERON:0000970 {source="PMID:21062451"} ! eye
is_a: UBERON:0002536 ! arthropod sensillum
relationship: part_of UBERON:0000018 ! compound eye
property_value: UBPROP:0000007 "ommatidial" xsd:string

[Term]
id: UBERON:0000974
name: neck
namespace: uberon
def: "An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column." [http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "collum" RELATED OMO:0003011 [Wikipedia:Neck]
synonym: "neck (volume)" RELATED [FMA:7155]
xref: AEO:0000108
xref: BTO:0000420
xref: CALOHA:TS-2045
xref: EFO:0000967
xref: EHDAA2:0003108
xref: EMAPA:35587
xref: FMA:7155
xref: GAID:86
xref: galen:Neck
xref: MA:0000024
xref: MAT:0000297
xref: MESH:D009333
xref: MIAA:0000297
xref: NCIT:C13063
xref: SCTID:302550007
xref: UMLS:C0027530 {source="ncithesaurus:Neck"}
xref: Wikipedia:Neck
is_a: UBERON:0000475 ! organism subdivision
relationship: anteriorly_connected_to UBERON:0000033 ! head
relationship: part_of RO:0002577 ! system
relationship: part_of UBERON:0000153 ! anterior region of body
relationship: posteriorly_connected_to UBERON:0002100 ! trunk
property_value: curator_notes "true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck." xsd:string
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/9/99/Female_neck.jpg" xsd:anyURI
property_value: RO:0002174 NCBITaxon:32443 {source="ISBN:9780674021839"}
property_value: UBPROP:0000007 "cervical" xsd:string

[Term]
id: UBERON:0000977
name: pleura
namespace: uberon
def: "The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion)." [https://github.com/obophenotype/uberon/issues/1231, ISBN:0-683-40008-8, MP:0010820, UBERON:cjm, Wikipedia:Pulmonary_pleurae]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "pleura" RELATED []
synonym: "pleural tissue" RELATED [BTO:0001791, NCIT:C12469]
synonym: "wall of pleural sac" EXACT []
xref: BTO:0001791
xref: CALOHA:TS-2081
xref: EFO:0001980
xref: EMAPA:16775
xref: EV:0100044
xref: FMA:9583
xref: GAID:360
xref: MA:0000433
xref: MESH:D010994
xref: NCIT:C12469
xref: SCTID:181609007
xref: UMLS:C0032225 {source="ncithesaurus:Pleural_Tissue"}
xref: VHOG:0000394
xref: Wikipedia:Pleura
is_a: UBERON:0000042 ! serous membrane
is_a: UBERON:0000077 ! mixed endoderm/mesoderm-derived structure
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: has_part UBERON:0002400 ! parietal pleura
intersection_of: has_part UBERON:0002401 ! visceral pleura
intersection_of: part_of UBERON:0009778 ! pleural sac
relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system
relationship: develops_from UBERON:0003081 ! lateral plate mesoderm
relationship: has_part UBERON:0002400 ! parietal pleura
relationship: has_part UBERON:0002401 ! visceral pleura
relationship: has_quality PATO:0001748 ! invaginated
relationship: only_in_taxon NCBITaxon:32524 ! Amniota
relationship: part_of UBERON:0009778 {source="https://github.com/obophenotype/uberon/issues/86"} ! pleural sac
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/a/ab/Gray965.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:8782 {source="ISBN:978-0030223693", source="https://orcid.org/0000-0003-3308-6245"}
property_value: UBPROP:0000001 "The serous membrane that covers the lungs and lines the pleural cavity. [Kaufman_MH_and_Bard_JBL, The_anatomical_basis_of_mouse_development_(1999)_San_Diego:_Academic_Press, p.264][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000394", ontology="VHOG", source="ISBN:0124020607", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "pleural" xsd:string
property_value: UBPROP:0000012 "In MA, is_a cavity lining (which we equate to parietal). In FMA, is_a (viscous) serous membrane (which includes mesothelium plus connective tissue). Note the MA structure should probably be associated with the mesothelium of pleura in FMA. JB/EHDAA2 argues the term 'pleura' is best used for the mesothelial lining (thus excluding connective tissue). See https://github.com/obophenotype/uberon/issues/86" xsd:string

[Term]
id: UBERON:0000982
name: skeletal joint
namespace: uberon
def: "Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]." [GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070, VSAO:0000101, Wikipedia:Joint]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "articular joint" RELATED [BTO:0001686]
synonym: "articulation" BROAD [VSAO:0000101]
synonym: "joint" BROAD [FMA:7490, VSAO:0000101]
synonym: "joints" RELATED OMO:0003004 [ZFA:0001596]
xref: AEO:0000182
xref: BTO:0001686
xref: CALOHA:TS-2023
xref: EFO:0000948
xref: EMAPA:35456
xref: FMA:7490
xref: GAID:102
xref: galen:Joint
xref: MA:0000319
xref: MAT:0000188
xref: MESH:D007596
xref: MIAA:0000188
xref: NCIT:C13044
xref: RETIRED_EHDAA2:0003182
xref: SCTID:302536002
xref: TAO:0000367
xref: UMLS:C0022417 {source="ncithesaurus:Joint"}
xref: VHOG:0001276
xref: VSAO:0000101
xref: Wikipedia:Joint
xref: XAO:0000171
xref: ZFA:0001596
is_a: UBERON:0004905 ! articulation
union_of: UBERON:0002217 ! synovial joint
union_of: UBERON:0011134 ! nonsynovial joint
disjoint_from: UBERON:0001474 ! bone element
relationship: connects UBERON:0004765 ! skeletal element
relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
property_value: UBPROP:0000001 "Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO]" xsd:string {date_retrieved="2012-08-14", external_class="VSAO:0000101", ontology="VSAO", source="PSPUB:0000170"}
property_value: UBPROP:0000001 "Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000367", ontology="TAO", source="TAO:pem"}

[Term]
id: UBERON:0000988
name: pons
namespace: uberon
def: "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum." [VHOG:0001176]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "pons cerebri" RELATED OMO:0003011 [NeuroNames:547]
synonym: "pons of Varolius" EXACT []
synonym: "pons Varolii" EXACT [ncithesaurus:Pons_Varolii]
xref: BAMS:PONS
xref: BAMS:Pons
xref: BIRNLEX:733
xref: BM:Pons
xref: BTO:0001101
xref: CALOHA:TS-0813
xref: DHBA:10661
xref: EFO:0001394
xref: EHDAA2:0004394
xref: EMAPA:17563
xref: EV:0100253
xref: FMA:67943
xref: GAID:578
xref: HBA:9131
xref: MA:0000204
xref: MAT:0000115
xref: MBA:771
xref: MESH:D011149
xref: MIAA:0000115
xref: NCIT:C12511
xref: neuronames:547 {source="BIRNLEX:733"}
xref: SCTID:279103004
xref: UMLS:C0032639 {source="BIRNLEX:733", source="ncithesaurus:Pons_Varolii"}
xref: UMLS:C1280999 {source="BIRNLEX:733"}
xref: VHOG:0001176
xref: Wikipedia:Pons
is_a: UBERON:0002616 ! regional part of brain
relationship: contributes_to_morphology_of UBERON:0001895 ! metencephalon
relationship: contributes_to_morphology_of UBERON:0002298 ! brainstem
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
relationship: part_of UBERON:0001895 {source="neuronames"} ! metencephalon
relationship: part_of UBERON:0002298 ! brainstem
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/3/36/Gray768.png" xsd:anyURI
property_value: editor_note "The pons is not present in zebrafish. In this ontology we currently have some structures which are applicable to zebrafish appearing as parts of the pons. Currently we only include the weaker dubious_for_taxon relationship ubtil this is resolved" xsd:string
property_value: RO:0002174 NCBITaxon:7955
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/pons"}
property_value: UBPROP:0000003 "During the embryonic development of birds and mammals, neuroblasts migrate from the cerebellum into the ventral part of the rhombencephalon and differentiate into pontine and other nuclei, which relay information from between the cerebrum and cerebellum, and a conspicuous band of transverse fibers. This region is known as the pons. A pons does not differentiate in reptiles and anamniotes (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001176", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.474", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0000989
name: penis
namespace: uberon
def: "An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0005187, Wikipedia:Penis]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
synonym: "penes" RELATED OMO:0003004 []
synonym: "phallus" RELATED []
xref: BTO:0000405
xref: CALOHA:TS-0758
xref: EFO:0000987
xref: EHDAA2:0001433
xref: EHDAA:9380
xref: EMAPA:18682
xref: EMAPA_RETIRED:18996
xref: EV:0100107
xref: FMA:9707
xref: GAID:389
xref: galen:Penis
xref: MA:0000408
xref: MAT:0000186
xref: MESH:D010413
xref: MIAA:0000186
xref: NCIT:C12409
xref: SCTID:265793009
xref: UMLS:C0030851 {source="ncithesaurus:Penis"}
xref: VHOG:0000727
xref: Wikipedia:Penis
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0008811 {source="Wikipedia"} ! intromittent organ
relationship: develops_from UBERON:0004876 {source="Wikipedia"} ! urogenital fold
relationship: develops_from UBERON:0005876 {source="EHDAA2"} ! undifferentiated genital tubercle
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/8/87/Labelled_flaccid_penis.jpg" xsd:anyURI
property_value: UBPROP:0000007 "penile" xsd:string
property_value: UBPROP:0000007 "phallic" xsd:string
property_value: UBPROP:0000008 "Most male birds (e.g., roosters and turkeys) have a cloaca (also present on the female), but not a penis. Among bird species with a penis are paleognathes (tinamous and ratites), Anatidae (ducks, geese and swans), and a very few other species (such as flamingoes). A bird penis is different in structure from mammal penises, being an erectile expansion of the cloacal wall and being erected by lymph, not blood. It is usually partially feathered and in some species features spines and brush-like filaments, and in flaccid state curls up inside the cloaca" xsd:string {source="WP"}

[Term]
id: UBERON:0000990
name: reproductive system
namespace: uberon
def: "Anatomical system that has as its parts the organs concerned with reproduction." [Wikipedia:Reproductive_system]
subset: efo_slim
subset: functional_classification
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "animal reproductive system" RELATED [BTO:0000081]
synonym: "genital system" NARROW []
synonym: "genital tract" RELATED []
synonym: "genitalia" NARROW OMO:0003004 []
synonym: "Geschlechtsorgan" RELATED [BTO:0000081]
synonym: "organa genitalia" RELATED [BTO:0000081]
synonym: "reproductive tissue" RELATED [BTO:0000081]
synonym: "reproductive tract" RELATED []
synonym: "systemata genitalia" RELATED OMO:0003011 [Wikipedia:Reproductive_system]
xref: AAO:0010258
xref: BILA:0000103
xref: BTO:0000081
xref: CALOHA:TS-1318
xref: EFO:0000809
xref: EHDAA2:0001603
xref: EHDAA:5923
xref: EMAPA:17381
xref: EV:0100100
xref: FBbt:00004857 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7160
xref: GAID:363
xref: HAO:0000374
xref: HAO:0000895
xref: MA:0000326
xref: MESH:D005835 {sssom:mapping_provider="https://github.com/biopragmatics/biomappings", sssom:mapping_justification="vocab:LexicalMatching"}
xref: MIAA:0000305
xref: NCIT:C12841
xref: SCTID:278875001
xref: TAO:0000632
xref: UMLS:C1261210 {source="ncithesaurus:Reproductive_System"}
xref: VHOG:0000182
xref: WBbt:0005747
xref: Wikipedia:Reproductive_system
xref: XAO:0000142
xref: ZFA:0000632
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: capable_of_part_of GO:0000003 ! reproduction
disjoint_from: UBERON:0001004 ! respiratory system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: capable_of_part_of GO:0000003 ! reproduction
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: has_part UBERON:0000991 ! gonad
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/5/52/Penis.svg" xsd:anyURI
property_value: editor_note "consider splitting genitalia from reproductive system" xsd:string
property_value: RO:0002175 NCBITaxon:9606
property_value: term:date "2022-06-10T18:22:34Z" xsd:dateTime
property_value: UBPROP:0000001 "Anatomical system which consists of organs and tissues associated with sexual reproduction of the organism.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010258", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Arguably, one of the most important aspects of urbilaterian organogenesis would have been gonadogenesis, since Urbilateria must have successfully generated gametes and developed a strategy for extrusion and fertilization, in order to be the ancestor of all living Bilateria.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000182", ontology="VHOG", source="PMID:21672850 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across Bilateria. Integrative and Comparative Biology (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000202 FMA:75572

[Term]
id: UBERON:0000991
name: gonad
namespace: uberon
def: "Reproductive organ that produces and releases eggs (ovary) or sperm (testis)." [ISBN:0140512888, Wikipedia:Gonad, ZFA:0000413, ZFIN:curator]
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "gonada" EXACT []
synonym: "gonads" RELATED OMO:0003004 [ZFA:0000413]
xref: AAO:0000213
xref: BILA:0000123
xref: BSA:0000079
xref: BTO:0000534
xref: EMAPA:17383
xref: FBbt:00004858 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:18250
xref: GAID:368
xref: HAO:0000379
xref: MA:0002420
xref: MESH:D006066
xref: NCIT:C12725
xref: SCTID:304623008
xref: TAO:0000413
xref: UMLS:C0018067 {source="ncithesaurus:Gonad"}
xref: VHOG:0000397
xref: WBbt:0005175
xref: Wikipedia:Gonad
xref: XAO:0003146
xref: ZFA:0000413
is_a: UBERON:0003133 ! reproductive organ
intersection_of: UBERON:0003133 ! reproductive organ
intersection_of: has_part CL:0000586 ! germ cell
relationship: contains_process GO:0007276 ! gamete generation
relationship: develops_from UBERON:0005564 ! gonad primordium
relationship: has_part CL:0000586 ! germ cell
property_value: UBPROP:0000001 "Anatomical structure which produces gametes as well as certain sex hormones controlled by the pituitary gonadotropins.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000213", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The part of the reproductive system that produces and releases eggs (ovary) or sperm (testis).[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000413", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000397", ontology="VHOG", source="DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T, Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "gonadal" xsd:string
property_value: UBPROP:0000012 "FMA xref is a 'general anatomical term'" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0000992
name: ovary
namespace: uberon
def: "The gonad of a female organism which contains germ cells." [ISBN:0-683-40008-8, MP:0001126, Wikipedia:Ovary]
subset: efo_slim
subset: human_reference_atlas
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "animal ovary" EXACT [EFO:0000973]
synonym: "female gonad" EXACT []
synonym: "female organism genitalia gonad" EXACT [OBOL:automatic]
synonym: "female organism genitalia gonada" EXACT [OBOL:automatic]
synonym: "female organism reproductive system gonad" EXACT [OBOL:automatic]
synonym: "female organism reproductive system gonada" EXACT [OBOL:automatic]
synonym: "female reproductive system gonad" EXACT [OBOL:automatic]
synonym: "female reproductive system gonada" EXACT [OBOL:automatic]
synonym: "genitalia of female organism gonad" EXACT [OBOL:automatic]
synonym: "genitalia of female organism gonada" EXACT [OBOL:automatic]
synonym: "gonad of female organism genitalia" EXACT [OBOL:automatic]
synonym: "gonad of female organism reproductive system" EXACT [OBOL:automatic]
synonym: "gonad of female reproductive system" EXACT [OBOL:automatic]
synonym: "gonad of genitalia of female organism" EXACT [OBOL:automatic]
synonym: "gonad of reproductive system of female organism" EXACT [OBOL:automatic]
synonym: "gonada of female organism genitalia" EXACT [OBOL:automatic]
synonym: "gonada of female organism reproductive system" EXACT [OBOL:automatic]
synonym: "gonada of female reproductive system" EXACT [OBOL:automatic]
synonym: "gonada of genitalia of female organism" EXACT [OBOL:automatic]
synonym: "gonada of reproductive system of female organism" EXACT [OBOL:automatic]
synonym: "ovaries" RELATED OMO:0003004 []
synonym: "ovarium" RELATED OMO:0003011 [Wikipedia:Ovary]
synonym: "ovum-producing ovary" EXACT SENSU [GO:0061039]
synonym: "reproductive system of female organism gonad" EXACT [OBOL:automatic]
synonym: "reproductive system of female organism gonada" EXACT [OBOL:automatic]
xref: AAO:0000371
xref: BILA:0000125
xref: BSA:0000080
xref: BTO:0000975
xref: CALOHA:TS-0730
xref: EFO:0000973
xref: EHDAA2:0001360
xref: EHDAA:8124
xref: EMAPA:17962
xref: EV:0100111
xref: FBbt:00004865 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7209
xref: GAID:367
xref: MA:0000384
xref: MESH:D010053
xref: MIAA:0000125
xref: NCIT:C12404
xref: SCTID:181464007
xref: TAO:0000403
xref: UMLS:C0029939 {source="ncithesaurus:Ovary"}
xref: VHOG:0000251
xref: Wikipedia:Ovary
xref: XAO:0000258
xref: ZFA:0000403
is_a: UBERON:0000991 ! gonad
is_a: UBERON:0003134 ! female reproductive organ
intersection_of: UBERON:0000991 ! gonad
intersection_of: part_of UBERON:0000474 ! female reproductive system
disjoint_from: UBERON:0009117 ! indifferent gonad
relationship: develops_from UBERON:0009117 ! indifferent gonad
relationship: in_lateral_side_of UBERON:0003975 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA-abduced-lr"} ! internal female genitalia
relationship: only_in_taxon NCBITaxon:33208 ! Metazoa
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Gray589.png" xsd:anyURI
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Either of paired female reproductive organs involved in production of ova and female sex hormones.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000371", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "Female reproductive organ.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000403", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "(...) while it is likely that Urbilateria lacked a complex somatic reproductive system, it is at present impossible to speculate on whether or not it possessed a true gonad, let alone any other somatic adaptations for reproduction (reference 1); Examination of different vertebrate species shows that the adult gonad is remarkably similar in its morphology across different phylogenetic classes. Surprisingly, however, the cellular and molecular programs employed to create similar organs are not evolutionarily conserved (reference 2).[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000251", ontology="VHOG", source="DOI:10.1093/icb/icm052 Extavour CGM, Gray anatomy: phylogenetic patterns of somatic gonad structures and reproductive strategies across the Bilateria. Integrative and Comparative Biology (2007), DOI:10.1146/annurev.cellbio.042308.13350 DeFalco T and Capel B, Gonad morphogenesis in vertebrates: divergent means to a convergent end. Annual review of cell and developmental biology (2009)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "ovarian" xsd:string
property_value: UBPROP:0000008 "Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous. Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity. Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct. Although most normal female vertebrates have two ovaries, this is not the case in all species. In birds and platypuses, the right ovary never matures, so that only the left is functional. In some elasmobranchs, the reverse is true, with only the right ovary fully developing. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo" xsd:string {source="WP"}

[Term]
id: UBERON:0000993
name: oviduct
namespace: uberon
def: "A tube or collection of tubes in an animal from the ovaries to the outside of the body." [http://orcid.org/0000-0002-6601-2165]
subset: efo_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "female reproductive tracts" RELATED [http://orcid.org/0000-0002-6601-2165]
synonym: "ovarian duct" EXACT [http://orcid.org/0000-0002-6601-2165]
synonym: "ovarian tube" EXACT [http://orcid.org/0000-0002-6601-2165]
synonym: "oviducts" RELATED OMO:0003004 [ZFA:0000560]
synonym: "tuba uterina" RELATED [BTO:0000980]
synonym: "tuba uterinae" RELATED [BTO:0000980]
synonym: "tubular parts of female reproductive system" RELATED [http://orcid.org/0000-0002-6601-2165]
synonym: "uterine tube" EXACT []
xref: AAO:0010533
xref: BSA:0000083
xref: BTO:0000980
xref: EFO:0000974
xref: EMAPA:18984
xref: GAID:366
xref: MAT:0000126
xref: MESH:D010057
xref: MIAA:0000126
xref: NCIT:C77957
xref: TAO:0000560
xref: UMLS:C0029954 {source="ncithesaurus:Oviduct"}
xref: VHOG:0001136
xref: Wikipedia:Oviduct
xref: XAO:0003052
xref: ZFA:0000560
is_a: UBERON:0000025 ! tube
is_a: UBERON:0005156 ! reproductive structure
relationship: connects UBERON:0000992 ! ovary
relationship: connects UBERON:0013514 ! space surrounding organism
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000474 ! female reproductive system
property_value: curator_notes "sometimes oviduct is used interchangeably with follaopian tube. Here they are different - the oviduct connects the gonad to the outside in a variety of animals. The mammal-class fallopian tube is derived from the mullerian duct and connects the gonads/infubdibulum to the uterus" xsd:string
property_value: UBPROP:0000001 "A passage through which ova leave the maternal body or pass to an organ communicating with the exterior of the body. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001136", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/oviduct"}
property_value: UBPROP:0000003 "In all remaining vertebrates (i.e., coelacanths, lungfishes, amphibians, reptiles, birds, and mammals), the oviduct arises in ontogeny as a longitudinal, groovelike invagination of the coelomic epithelium on the lateral surface of the mesonephros.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001136", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.687-688", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "in birds divided into infundibulum, magnum, isthmus, uterus, and vagina" xsd:string
property_value: UBPROP:0000008 "The only female vertebrates to lack oviducts are the jawless fishes. In these species, the single fused ovary releases eggs directly into the body cavity. The fish eventually extrudes the eggs through small genital pores towards the rear of the body[WP]" xsd:string

[Term]
id: UBERON:0000995
name: uterus
namespace: uberon
def: "The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth." [MGI:csmith, MP:0001120]
subset: efo_slim
subset: human_reference_atlas
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
xref: BTO:0001424
xref: CALOHA:TS-1102
xref: EFO:0000975
xref: EMAPA:29915
xref: EV:0100113
xref: FMA:17558
xref: GAID:172
xref: galen:Uterus
xref: MA:0000389
xref: MAT:0000127
xref: MESH:D014599
xref: MIAA:0000127
xref: NCIT:C12405
xref: SCTID:181452004
xref: UMLS:C0042149 {source="ncithesaurus:Uterus"}
xref: VHOG:0001137
xref: Wikipedia:Uterus
is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct
relationship: develops_from UBERON:0005795 ! embryonic uterus
relationship: immediate_transformation_of UBERON:0005795 ! embryonic uterus
relationship: only_in_taxon NCBITaxon:32525 ! Theria <mammals>
relationship: part_of UBERON:0004175 ! internal genitalia
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/6/6a/Female_reproductive_system_lateral_nolabel.png" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Uterus.glb" xsd:anyURI
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/c/cb/Female_anatomy.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The hollow muscular organ in female mammals in which the blastocyst normally becomes embedded and in which the developing embryo and fetus is nourished. Its cavity opens into the vagina below and into a uterine tube on either side. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/uterus"}
property_value: UBPROP:0000003 "An infundibulum, uterine tube, uterus, and vagina also differentiate along the oviducts of eutherian mammals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001137", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.678", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "uterine" xsd:string
property_value: UBPROP:0000008 "Most animals that lay eggs, such as birds and reptiles, have an oviduct instead of a uterus. In monotremes, mammals which lay eggs and include the platypus, either the term uterus or oviduct is used to describe the same organ, but the egg does not develop a placenta within the mother and thus does not receive further nourishment after formation and fertilization. Marsupials have two uteruses, each of which connect to a lateral vagina and which both use a third, middle 'vagina' which functions as the birth canal. Marsupial embryos form a choriovitelline 'placenta' (which can be thought of as something between a monotreme egg and a 'true' placenta), in which the egg's yolk sac supplies a large part of the embryo's nutrition but also attaches to the uterine wall and takes nutrients from the mother's bloodstream." xsd:string
property_value: UBPROP:0000011 "Two uteruses usually form initially in a female fetus, and in placental mammals they may partially or completely fuse into a single uterus depending on the species. In many species with two uteruses, only one is functional. Humans and other higher primates such as chimpanzees, along with horses, usually have a single completely fused uterus, although in some individuals the uteruses may not have completely fused [Wikipedia:Uterus]" xsd:string

[Term]
id: UBERON:0000997
name: mammalian vulva
namespace: uberon
def: "External genital organs of the female mammal[WP]." [Wikipedia:Vulva]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "female pudendum" EXACT DEPRECATED [BTO:0003101, doi:10.1002/ca.23705, FMA:20462]
synonym: "mammalian vulva" EXACT []
synonym: "puboperineal region" EXACT [FMA:20462]
synonym: "pudendum" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705]
synonym: "pudendum femininum" EXACT DEPRECATED [doi:10.1002/ca.23705, FMA:20462, FMA:TA]
synonym: "pudendum femininum" RELATED DEPRECATED [doi:10.1002/ca.23705, Wikipedia:Vulva]
synonym: "pudendum muliebre" RELATED DEPRECATED [BTO:0003101, doi:10.1002/ca.23705]
synonym: "vulva" EXACT [MA:0000395]
xref: BTO:0003101
xref: CALOHA:TS-1168
xref: EFO:0000978
xref: EMAPA:36631
xref: EV:0100118
xref: FMA:20462
xref: GAID:383
xref: galen:Vulva
xref: MA:0000395
xref: MAT:0000169
xref: MESH:D014844
xref: MIAA:0000169
xref: NCIT:C12408
xref: SCTID:265796001
xref: UMLS:C0042993 {source="ncithesaurus:Vulva"}
xref: VHOG:0001458
xref: Wikipedia:Vulva
is_a: UBERON:0000062 ! organ
is_a: UBERON:0005156 ! reproductive structure
relationship: only_in_taxon NCBITaxon:40674 ! Mammalia
relationship: part_of UBERON:0005056 ! external female genitalia
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/da/Female_unshaved_genitalia.jpg" xsd:anyURI
property_value: UBPROP:0000001 "The external genital organs of the female, including the labia majora, labia minora, clitoris, and vestibule of the vagina. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001458", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/vulva"}
property_value: UBPROP:0000007 "vulval" xsd:string

[Term]
id: UBERON:0000998
name: seminal vesicle
namespace: uberon
def: "Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct." [BTO:0001234, Wikipedia:Seminal_vesicle]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
synonym: "glandula seminalis" RELATED [BTO:0001234]
synonym: "glandula vesiculosa" RELATED [BTO:0001234]
synonym: "gonecyst" RELATED []
synonym: "seminal gland" BROAD []
synonym: "vas efferens" RELATED []
synonym: "vesicula seminalis" RELATED [BTO:0001234, Wikipedia:Seminal_vesicle]
synonym: "vesiculae seminales" RELATED OMO:0003011 [Wikipedia:Seminal_vesicle]
synonym: "vesicular gland" RELATED [Wikipedia:Seminal_vesicle]
synonym: "vesicular glands" RELATED [Wikipedia:Seminal_vesicle]
synonym: "vesicular seminalis" RELATED [Wikipedia:Seminal_vesicle]
synonym: "vesiculæ seminales" RELATED [Wikipedia:Seminal_vesicle]
xref: AAO:0010788
xref: BTO:0001234
xref: CALOHA:TS-0919
xref: EFO:0000986
xref: EMAPA:19180
xref: EV:0100106
xref: FMA:19386
xref: GAID:394
xref: MA:0000410
xref: MAT:0000171
xref: MESH:D012669
xref: MIAA:0000171
xref: NCIT:C12787
xref: SCTID:181434004
xref: UMLS:C0036628 {source="ncithesaurus:Seminal_Vesicle"}
xref: VHOG:0001379
xref: Wikipedia:Seminal_vesicle
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0006868 ! seminal fluid secreting gland
relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia
relationship: develops_from UBERON:0000080 ! mesonephros
relationship: part_of UBERON:0000473 ! testis
relationship: produces UBERON:0010143 ! seminal vesicle fluid
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:anyURI
property_value: UBPROP:0000001 "Either of a pair of pouchlike glands situated on each side of the male urinary bladder that secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/prominence"}
property_value: UBPROP:0000003 "(In mammalian testis) Along the way (the sperm travel), three accessory sex glands, the seminal vesicle, prostate, and bulbourethral (Cowper's) gland, respectively, add their secretions as sperm move from the testes to the urethra.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001379", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.556", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000009 "The seminal vesicles secrete a significant proportion of the fluid that ultimately becomes semen. Lipofuscin granules from dead epithelial cells give the secretion its yellowish color. About 50-70% of the seminal fluid in humans originates from the seminal vesicles, but is not expelled in the first ejaculate fractions which are dominated by spermatozoa and zinc-rich prostatic fluid." xsd:string

[Term]
id: UBERON:0000999
name: ejaculatory duct
namespace: uberon
def: "The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted]." [Wikipedia:Ejaculatory_duct]
subset: efo_slim
subset: uberon_slim
synonym: "ductus ejaculatorii" EXACT OMO:0003004 [BTO:0001580]
synonym: "ductus ejaculatorii" RELATED OMO:0003011 [Wikipedia:Ejaculatory_duct]
synonym: "ductus ejaculatorius" EXACT [BTO:0001580]
xref: BTO:0001580
xref: CALOHA:TS-0211
xref: EFO:0000985
xref: EMAPA:19088
xref: FMA:19325
xref: GAID:388
xref: MA:0003247
xref: MAT:0000170
xref: MESH:D004543
xref: MIAA:0000170
xref: NCIT:C32493
xref: SCTID:279665005
xref: UMLS:C0013747 {source="ncithesaurus:Ejaculatory_Duct"}
xref: Wikipedia:Ejaculatory_duct
is_a: UBERON:0000025 ! tube
is_a: UBERON:0005904 ! duct of male reproductive system
is_a: UBERON:0015212 ! lateral structure
relationship: capable_of_part_of GO:0042713 ! sperm ejaculation
relationship: channel_for UBERON:0001968 ! semen
relationship: channel_for UBERON:0010143 ! seminal vesicle fluid
relationship: channels_from UBERON:0000998 ! seminal vesicle
relationship: channels_from UBERON:0001000 ! vas deferens
relationship: channels_into UBERON:0000057 ! urethra
relationship: in_lateral_side_of UBERON:0000079 ! male reproductive system
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Prostate.glb" xsd:anyURI
property_value: depiction "https://upload.wikimedia.org/wikipedia/commons/3/35/Male_anatomy.png" xsd:anyURI

[Term]
id: UBERON:0001000
name: vas deferens
namespace: uberon
def: "A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MGI:pvb, MP:0002769, Wikipedia:Vas_deferens]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "deferent duct" EXACT []
synonym: "ductus deferens" EXACT [Wikipedia:Vas_deferens]
synonym: "sperm duct" RELATED []
synonym: "vas deferen" EXACT []
synonym: "vasa deferentia" RELATED []
xref: BTO:0001427
xref: CALOHA:TS-1105
xref: EFO:0000981
xref: EMAPA:18681
xref: EV:0100105
xref: FMA:19234
xref: GAID:404
xref: galen:VasDeferens
xref: MA:0000413
xref: MESH:D014649
xref: MIAA:0000129
xref: NCIT:C12813
xref: SCTID:245467009
xref: UMLS:C0042360 {source="ncithesaurus:Vas_Deferens"}
xref: VHOG:0001135
xref: Wikipedia:Vas_deferens
is_a: UBERON:0000025 ! tube
is_a: UBERON:0005904 ! duct of male reproductive system
relationship: channel_for UBERON:0001968 ! semen
relationship: channels_from UBERON:0001301 ! epididymis
relationship: channels_into UBERON:0000999 ! ejaculatory duct
relationship: contributes_to_morphology_of UBERON:0004054 ! internal male genitalia
relationship: only_in_taxon NCBITaxon:32524 ! Amniota
relationship: part_of UBERON:0005352 {source="FMA"} ! spermatic cord
relationship: part_of UBERON:0006947 ! male genital duct
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d1/Male_anatomy_en.svg" xsd:anyURI
property_value: UBPROP:0000003 "The continuation of the archinephric duct, now called the deferent duct, extends caudally to the cloaca or to the part of the mammalian urethra that is derived from the cloaca.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001135", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.670", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "Most vertebrates have some form of duct to transfer the sperm from the testes to the urethra. In cartilaginous fish and amphibians, sperm is carried through the archinephric duct, which also partially helps to transport urine from the kidneys. In teleosts, there is a distinct sperm duct, separate from the ureters, and often called the vas deferens, although probably not truly homologous with that in humans. In cartilaginous fishes, the part of the archinephric duct closest to the testis is coiled up to form an epididymis. Below this are a number of small glands secreting components of the seminal fluid. The final portion of the duct also receives ducts from the kidneys in most species. In amniotes, however, the archinephric duct has become a true vas deferens, and is used only for conducting sperm, never urine. As in cartilaginous fish, the upper part of the duct forms the epididymis. In many species, the vas deferens ends in a small sac for storing sperm. The only vertebrates to lack any structure resembling a vas deferens are the primitive jawless fishes, which release sperm directly into the body cavity, and then into the surrounding water through a simple opening in the body wall." xsd:string {source="WP"}

[Term]
id: UBERON:0001001
name: chitin-based cuticle
namespace: uberon
def: "A cuticular covering that is composed primarily of chitin. The main structural component of arthropod cuticle is a polysaccharide, chitin, composed of N-acetylglucosamine units, together with proteins and lipids[WP]." [https://orcid.org/0000-0002-6601-2165, https://sourceforge.net/tracker/index.php?func=detail&aid=3348965&group_id=36855&atid=440764, Wikipedia:Arthropod_exoskeleton, Wikipedia:Cuticle#Invertebrate_zoology]
comment: EDITOR_NOTE TODO - split from exoskeleton? Also: See above sf item to see if this belongs in GO
subset: efo_slim
subset: uberon_slim
synonym: "arthropod cuticle" RELATED []
synonym: "arthropod exoskeleton" RELATED [Wikipedia:Arthropod_exoskeleton]
synonym: "cuticle" NARROW [FBbt:00004970]
synonym: "exoskeleton" BROAD []
synonym: "insect cuticle" RELATED []
xref: EFO:0000944
xref: FBbt:00004970 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: HAO:0000240
xref: MAT:0000150
xref: MIAA:0000150
xref: Wikipedia:Arthropod_exoskeleton
is_a: UBERON:0001002 ! cuticle
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0007491 ! chitin-based acellular structure
intersection_of: UBERON:0001002 ! cuticle
intersection_of: composed_primarily_of CHEBI:17029 ! chitin
relationship: develops_from UBERON:0007376 ! outer epithelium
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
relationship: part_of UBERON:0002416 ! integumental system

[Term]
id: UBERON:0001002
name: cuticle
namespace: uberon
def: "Tough but flexible, non-mineral outer coverings of an organism, or parts of an organism, that provide protection. Cuticles are non-homologous, differing in their origin, structure and chemical composition[WP]." [http://sourceforge.net/tracker/?func=detail&aid=3348965&group_id=36855&atid=440764, Wikipedia:Cuticle]
comment: EDITOR_NOTE TODO - check cuticle vs exoskeleton. Note that GO has a very generic definition of cuticle. See also arthropod-anatomy ontology. Note in ncit Cuticle is a plant part
subset: grouping_class
subset: non_informative
subset: uberon_slim
synonym: "cuticula" RELATED [BTO:0001600]
synonym: "cuticular exoskeleton" RELATED []
xref: BTO:0001600
xref: Wikipedia:Cuticle
is_a: UBERON:0000476 ! acellular anatomical structure
relationship: only_in_taxon NCBITaxon:6072 {source="Rieger - Evolution of the Cuticle in the Lower Eumetazoa"} ! Eumetazoa
property_value: UBPROP:0000007 "cuticular" xsd:string

[Term]
id: UBERON:0001003
name: skin epidermis
namespace: uberon
def: "The outer epithelial layer of the skin that is superficial to the dermis." [http://orcid.org/0000-0002-6601-2165, ISBN:0073040584]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "epidermis" BROAD []
synonym: "skin" BROAD []
synonym: "vertebrate epidermis" EXACT []
xref: AAO:0000143
xref: BTO:0000404
xref: CALOHA:TS-0283
xref: EFO:0000954
xref: EMAPA:17528
xref: EV:0100153
xref: FMA:70596
xref: GAID:932
xref: MA:0000153
xref: MAT:0000154
xref: MESH:D004817
xref: MIAA:0000154
xref: NCIT:C12708
xref: SCTID:361694003
xref: TAO:0000105
xref: UMLS:C0014520 {source="ncithesaurus:Epidermis"}
xref: VHOG:0000077
xref: Wikipedia:Epidermis_(skin)
xref: XAO:0000028
xref: ZFA:0000105
is_a: UBERON:0007376 ! outer epithelium
is_a: UBERON:3000961 ! external integument structure
intersection_of: UBERON:0007376 ! outer epithelium
intersection_of: part_of UBERON:0002097 ! skin of body
relationship: adjacent_to UBERON:0002067 ! dermis
relationship: developmentally_replaces UBERON:0003055 ! periderm
relationship: part_of UBERON:0002097 ! skin of body
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000105", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000002 "relationship loss: subclass external integument structures (AAO:0000961)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000143", ontology="AAO"}
property_value: UBPROP:0000003 "(...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000077", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.71-72", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "epidermal" xsd:string
property_value: UBPROP:0000008 "Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes)." xsd:string

[Term]
id: UBERON:0001004
name: respiratory system
namespace: uberon
def: "Functional system which consists of structures involved in respiration." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Respiratory_system]
subset: efo_slim
subset: functional_classification
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "apparatus respiratorius" EXACT []
synonym: "apparatus respiratorius" RELATED [BTO:0000203]
synonym: "Atmungssystem" RELATED [BTO:0000203]
synonym: "respiratory system" EXACT []
synonym: "systema respiratorium" RELATED OMO:0003011 [Wikipedia:Respiratory_system]
xref: AAO:0000541
xref: BTO:0000203
xref: CALOHA:TS-1319
xref: EFO:0000804
xref: EHDAA2:0001604
xref: EHDAA:2203
xref: EMAPA:16727
xref: EV:0100036
xref: FMA:7158
xref: GAID:78
xref: MA:0000327
xref: MAT:0000030
xref: MESH:D012137
xref: MIAA:0000030
xref: NCIT:C12779
xref: SCTID:278197002
xref: TAO:0000272
xref: UMLS:C0035237 {source="ncithesaurus:Respiratory_System"}
xref: VHOG:0000202
xref: Wikipedia:Respiratory_system
xref: XAO:0000117
xref: ZFA:0000272
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
disjoint_from: UBERON:0001007 ! digestive system
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: capable_of GO:0003016 ! respiratory system process
relationship: capable_of GO:0007585 ! respiratory gaseous exchange by respiratory system
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.0/VH_F_Lung.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Lung.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Lung.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-f-lung.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.4/3d-vh-m-lung.glb" xsd:anyURI
property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000541", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000202", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001005
name: respiratory airway
namespace: uberon
def: "An airway through which respiratory air passes in organisms." [Wikipedia:Trachea]
subset: grouping_class
subset: uberon_slim
synonym: "airway" BROAD [http://orcid.org/0000-0002-6601-2165]
synonym: "airways" BROAD OMO:0003004 [http://orcid.org/0000-0002-6601-2165]
xref: FMA:265130
xref: SCTID:361380005
xref: Wikipedia:Trachea
is_a: UBERON:0003103 ! compound organ
is_a: UBERON:0004111 ! anatomical conduit
relationship: channel_for UBERON:0034874 ! air in respiratory system
relationship: part_of UBERON:0001004 ! respiratory system
property_value: curator_notes "This class generically groups trachea and analagous structures throughout metazoa. Consider renaming, as the term could be taken to mean lumen of tracheal system (e.g. in SNOMED). As a grouping class this is quite vague, as it is not clear where the airway begins and ends" xsd:string

[Term]
id: UBERON:0001007
name: digestive system
namespace: uberon
def: "Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes." [FB:gg, NLM:alimentary+system, Wikipedia:Digestive_system]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "alimentary system" RELATED []
synonym: "alimentary tract" RELATED []
synonym: "gastrointestinal system" RELATED []
synonym: "gut" RELATED []
xref: AAO:0000129
xref: BILA:0000082
xref: BTO:0000058
xref: CALOHA:TS-1293
xref: EFO:0000793
xref: EV:0100056
xref: FBbt:00005055 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7152
xref: GAID:278
xref: galen:DigestiveSystem
xref: MA:0002431
xref: MAT:0000018
xref: MESH:D004064
xref: MIAA:0000018
xref: ncithesaurus:Digestive_System
xref: SCTID:278859004
xref: TADS:0000170
xref: TAO:0000339
xref: WBbt:0005748
xref: Wikipedia:Digestive_system
xref: XAO:0000125
xref: ZFA:0000339
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: capable_of GO:0022600 ! digestive system process
disjoint_from: UBERON:0001009 ! circulatory system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: capable_of GO:0022600 ! digestive system process
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000129", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000007 "digestive" xsd:string
property_value: UBPROP:0000012 "many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0001008
name: renal system
namespace: uberon
def: "The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [DOI:10.1371/journal.pone.0099864, GO:0072001]
comment: EDITOR_NOTE In various sources such as Encyclopedia Britannica, the excretory and urinary systems are indeed the same system (see wikipedia talk page); we merge two BTO classes here
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "excretory system" BROAD []
synonym: "renal or urinary system" RELATED [EHDAA:5901]
synonym: "renal/urinary system" RELATED []
synonym: "systema urinaria" EXACT [FMA:7159]
synonym: "systema urinarium" EXACT [BTO:0003092]
synonym: "urinary system" EXACT []
synonym: "urinary tract" EXACT []
xref: AAO:0010257
xref: BILA:0000015
xref: BTO:0001244
xref: BTO:0003092
xref: CALOHA:TS-1323
xref: EFO:0000803
xref: EHDAA2:0001601
xref: EHDAA:5901
xref: EMAPA:17366
xref: EV:0100095
xref: FBbt:00005056 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7159
xref: GAID:391
xref: galen:UrinaryTract
xref: MA:0000325
xref: MAT:0000027
xref: MESH:D014551
xref: MIAA:0000027
xref: NCIT:C12413
xref: SCTID:362204003
xref: TADS:0000162
xref: TAO:0000163
xref: UMLS:C1508753 {source="ncithesaurus:Urinary_System"}
xref: VHOG:0000723
xref: WBbt:0005736
xref: Wikipedia:Excretory_system
xref: XAO:0000143
xref: ZFA:0000163
is_a: UBERON:8450002 ! excretory system
intersection_of: UBERON:8450002 ! excretory system
intersection_of: capable_of GO:0097254 ! renal tubular secretion
relationship: capable_of GO:0097254 ! renal tubular secretion
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: RO:0002161 NCBITaxon:110815 {source="Wikipedia"}
property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "An anatomical system which consists of organs and tissues which produce, store, and excrete urine.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010257", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Evolution of vertebrate renal anatomy appears quite conservative when compared, for example, to evolution of respiratory and cardiovascular systems in vertebrates. Major anatomical changes in vertebrates kidneys separate those of birds and mammals from kidneys of lower vertebrates. General increase in animal size from fish to mammals is reflected by an increase in total number of nephrons per kidney, rather than by constant change in tubular dimensions.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000723", ontology="VHOG", source="ISBN:978-3540428541 Kapoor BG, Bhavna Khanna, Ichthyology Handbook (2004) p.406", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels" xsd:string {source="GO"}
property_value: UBPROP:0000008 "This definition is inclusive of the organs of the vertebrate renal system, as well as the Malpighian tubules of insects, and allows for future incorporation of structures such as the antennal glands of crustaceans" xsd:string {source="DOI:10.1371/journal.pone.0099864"}

[Term]
id: UBERON:0001009
name: circulatory system
namespace: uberon
def: "Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]." [Wikipedia:Circulatory_system]
subset: human_reference_atlas
subset: uberon_slim
synonym: "systema cardiovasculare" RELATED OMO:0003011 [Wikipedia:Circulatory_system]
xref: AAO:0000959
xref: CALOHA:TS-2103
xref: MESH:D002319 {sssom:mapping_provider="https://github.com/biopragmatics/biomappings", sssom:mapping_justification="vocab:LexicalMatching"}
xref: VHOG:0001248
xref: Wikipedia:Circulatory_system
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001016 ! nervous system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: capable_of GO:0003013 ! circulatory system process
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
property_value: curator_notes "the cardiovascular system and the lymphatic system are parts of the circulatory system" xsd:string
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg" xsd:anyURI
property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
property_value: RO:0002161 NCBITaxon:6073
property_value: RO:0002161 NCBITaxon:6157
property_value: RO:0002174 NCBITaxon:6231 {notes="WBbt coelomocyte currently classified as circulating cell"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000959", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001248", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.493", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001013
name: adipose tissue
namespace: uberon
def: "Portion of connective tissue composed of adipocytes enmeshed in areolar tissue." [http://orcid.org/0000-0002-6601-2165, MESH:A10.165.114, MGI:cwg, MP:0000003, Wikipedia:Adipose_tissue]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "adipose" RELATED [BTO:0001487]
synonym: "bodyfat" RELATED [BTO:0001487]
synonym: "fat" EXACT [MA:0000009]
synonym: "fat tissue" EXACT []
synonym: "fatty depot" RELATED []
synonym: "fatty tissue" EXACT []
xref: AAO:0000001
xref: AEO:000020
xref: BTO:0001487
xref: CALOHA:TS-0013
xref: EFO:0000790
xref: EHDAA2:0003120
xref: EMAPA:35112
xref: EV:0100381
xref: FMA:20110
xref: GAID:920
xref: galen:FattyTissue
xref: MA:0000009
xref: MAT:0000015
xref: MESH:D000273
xref: MIAA:0000015
xref: NCIT:C12472
xref: SCTID:55603005
xref: TAO:0002134
xref: UMLS:C0001527 {source="ncithesaurus:Adipose_Tissue"}
xref: VHOG:0001284
xref: Wikipedia:Adipose_tissue
xref: XAO:0003049
xref: ZFA:0005345
is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: composed_primarily_of CL:0000136 ! adipocyte
disjoint_from: UBERON:0003714 ! neural tissue
relationship: composed_primarily_of CL:0000136 ! adipocyte
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Connective tissue in which fat is stored.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002134", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO", source="AAO:LAP"}
property_value: UBPROP:0000002 "relationship loss: subclass connective tissue proper (AAO:0000099)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000001", ontology="AAO"}
property_value: UBPROP:0000003 "Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001284", ontology="VHOG", source="DOI:10.1017/S0029665107005423 Haugen F, Drevon CA, The interplay between nutrients and the adipose tissue. The Proceedings of the Nutrition Society (2007)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "adipose" xsd:string
property_value: UBPROP:0000008 "In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen." xsd:string
property_value: UBPROP:0000012 "in FMA this is dense irregular connective tissue" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0001015
name: musculature
namespace: uberon
def: "A subdivision of the muscular system corresponding to a subdisivision of an organism." [https://orcid.org/0000-0002-6601-2165, Wikipedia:Muscular_system]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "muscle group" EXACT []
synonym: "muscle system" RELATED []
synonym: "muscles" RELATED []
synonym: "muscles set" EXACT []
synonym: "musculature" EXACT []
synonym: "musculature system" RELATED []
synonym: "musculi" EXACT OMO:0003011 [FMA:32558, FMA:TA]
synonym: "set of muscles" EXACT [FMA:32558]
synonym: "set of skeletal muscles" EXACT [MA:0000165]
xref: AAO:0011066
xref: BTO:0000887
xref: EFO:0001949
xref: EMAPA:32715
xref: EMAPA:35577
xref: FMA:32558
xref: MA:0000165
xref: NCIT:C13056
xref: TAO:0000548
xref: UMLS:C0026845 {source="ncithesaurus:Muscle"}
xref: VSAO:0005038
xref: WBbt:0005737
xref: Wikipedia:Muscular_system
xref: ZFA:0000548
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png" xsd:anyURI
property_value: RO:0002171 UBERON:0001474
property_value: UBPROP:0000012 "In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here." xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0001016
name: nervous system
namespace: uberon
def: "The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]." [BIRNLEX:844, ISBN:0-14-051288-8, ISBN:3110148986, NLM:nervous+system, WB:rynl, Wikipedia:Nervous_system, ZFIN:curator]
subset: cumbo
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "nerve net" NARROW [Wikipedia:Nerve_net]
synonym: "neurological system" EXACT [GO:0050877]
synonym: "systema nervosum" RELATED OMO:0003011 [Wikipedia:Nervous_system]
xref: AAO:0000324
xref: BILA:0000079
xref: BIRNLEX:844
xref: BTO:0001484
xref: CALOHA:TS-1313
xref: EFO:0000802
xref: EHDAA2:0001246
xref: EHDAA:826
xref: EMAPA:16469
xref: EV:0100162
xref: FBbt:00005093 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:7157
xref: GAID:466
xref: MA:0000016
xref: MAT:0000026
xref: MESH:D009420
xref: MIAA:0000026
xref: NCIT:C12755
xref: neuronames:3236
xref: SCTID:278196006
xref: TAO:0000396
xref: UMLS:C0027763 {source="ncithesaurus:Nervous_System"}
xref: VHOG:0000402
xref: WBbt:0005735
xref: Wikipedia:Nervous_system
xref: XAO:0000177
xref: ZFA:0000396
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
disjoint_from: UBERON:0002416 ! integumental system
disjoint_from: UBERON:0002423 ! hepatobiliary system
disjoint_from: UBERON:0004456 ! entire sense organ system
disjoint_from: UBERON:8450002 ! excretory system
relationship: capable_of GO:0050877 ! nervous system process
relationship: composed_primarily_of CL:0002319 ! neural cell
relationship: develops_from UBERON:0016880 ! future nervous system
relationship: existence_ends_during UBERON:0000066 ! fully formed stage
relationship: has_part CL:0000540 ! neuron
relationship: immediate_transformation_of UBERON:0016880 {source="Bgee:AN"} ! future nervous system
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg" xsd:anyURI
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png" xsd:anyURI
property_value: RO:0002161 NCBITaxon:6040
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000396", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000324", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000003 "Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000402", ontology="VHOG", source="ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "nervous" xsd:string
property_value: UBPROP:0000007 "neural" xsd:string

[Term]
id: UBERON:0001017
name: central nervous system
namespace: uberon
def: "The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord." [GO:0021551, http://www.frontiersinzoology.com/content/7/1/29, https://sourceforge.net/p/geneontology/ontology-requests/11422/]
subset: cumbo
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "cerebrospinal axis" NARROW [FMA:55675]
synonym: "CNS" EXACT OMO:0003000 []
synonym: "neuraxis" RELATED [FMA:55675]
synonym: "systema nervosum centrale" EXACT OMO:0003011 [FMA:55675, FMA:TA]
xref: AAO:0000090
xref: BAMS:CNS
xref: BILA:0000080
xref: BIRNLEX:1099
xref: BTO:0000227
xref: CALOHA:TS-0150
xref: EFO:0000908
xref: EHDAA2:0000225
xref: EHDAA:828
xref: EMAPA:16470
xref: EMAPA:16754
xref: EV:0100163
xref: FBbt:00005094 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:55675
xref: GAID:570
xref: MA:0000167
xref: MAT:0000457
xref: MESH:D002490
xref: NCIT:C12438
xref: neuronames:854
xref: SCTID:278199004
xref: TAO:0000012
xref: UMLS:C0927232 {source="ncithesaurus:Central_Nervous_System", source="BIRNLEX:1099"}
xref: VHOG:0000293
xref: Wikipedia:Central_nervous_system
xref: XAO:0000215
xref: ZFA:0000012
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011216 {source="FBbt", source="cjm"} ! organ system subdivision
relationship: develops_from UBERON:0001049 {gci_relation="part_of", gci_filler="NCBITaxon:7742", evidence="definitional"} ! neural tube
relationship: develops_from UBERON:0016879 ! future central nervous system
relationship: immediate_transformation_of UBERON:0016879 {source="Bgee:AN"} ! future central nervous system
relationship: only_in_taxon NCBITaxon:33213 ! Bilateria
relationship: part_of UBERON:0001016 ! nervous system
property_value: RO:0002161 NCBITaxon:147099 {source="Wikipedia:Acoelomorpha"}
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Part of the nervous system which includes the brain and spinal cord.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000090", ontology="AAO", source="AAO:BJB"}
property_value: UBPROP:0000001 "The brain and spinal cord. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000012", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO)." xsd:string {source="BIRNLEX:1099"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000293", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 (reference 1), ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 (reference 2), DOI:10.1016/j.cell.2007.02.040 Denes AS, Jekely G, Steinmetz PRH, Raible F, Snyman H, Prud'homme B, Ferrier DEK, Balavoine G and Arendt D, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in Bilateria. Cell (2007) (reference 3)", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001021
name: nerve
namespace: uberon
def: "An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures." [FBbt:00005105, http://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "nerves" EXACT OMO:0003004 [TAO:0007009]
synonym: "neural subtree" RELATED [FMA:65132]
synonym: "peripheral nerve" EXACT [http://orcid.org/0000-0002-6601-2165]
xref: AAO:0011070
xref: AEO:0000137
xref: BAMS:n
xref: BIRNLEX:1615
xref: BSA:0000098
xref: BTO:0000925
xref: BTO:0001027
xref: CALOHA:TS-0772
xref: EHDAA2:0003137
xref: EHDAA:2851
xref: EHDAA:3776
xref: EHDAA:4657
xref: EMAPA:32808
xref: EMAPA:32815
xref: EV:0100371
xref: FBbt:00005105 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:65132
xref: FMA:65239
xref: GAID:747
xref: GAID:758
xref: galen:Nerve
xref: MA:0000217
xref: MA:0000228
xref: MESH:D010525
xref: NCIT:C12466
xref: NCIT:C12768
xref: NLX:147826
xref: SCTID:244457007
xref: SCTID:256864008
xref: TAO:0007009
xref: UMLS:C0027740 {source="ncithesaurus:Nerve"}
xref: UMLS:C0031119 {source="ncithesaurus:Peripheral_Nerve"}
xref: VHOG:0000901
xref: Wikipedia:Nervous_system
xref: XAO:0000204
xref: XAO:0003047
xref: ZFA:0007009
is_a: UBERON:0000122 {source="FBbt"} ! neuron projection bundle
relationship: has_developmental_contribution_from UBERON:0002342 {gci_relation="part_of", gci_filler="NCBITaxon:7742", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! neural crest
relationship: has_quality PATO:0002045 ! dendritic
relationship: part_of UBERON:0000010 ! peripheral nervous system
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "A portion of tissue which is a fasiculated group of axons.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0007009", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000007 "nervous" xsd:string

[Term]
id: UBERON:0001027
name: sensory nerve
namespace: uberon
def: "A nerve that transmits from sensory receptors on the surface of the body to the central nervous system." [UBERON:cjm, Wikipedia:Sensory_nerve]
subset: pheno_slim
subset: uberon_slim
synonym: "afferent nerve" RELATED []
synonym: "nervus sensorius" EXACT OMO:0003011 [Wikipedia:Sensory_nerve]
xref: AEO:0000201
xref: EHDAA2:0003200
xref: FBbt:00005136 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:5868
xref: Wikipedia:Sensory_nerve
is_a: UBERON:0001021 ! nerve
relationship: has_part CL:0000526 {source="AEO"} ! afferent neuron

[Term]
id: UBERON:0001032
name: sensory system
namespace: uberon
def: "Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information." [Wikipedia:Sensory_system]
subset: efo_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "organa sensuum" EXACT OMO:0003011 [FMA:75259, FMA:TA]
synonym: "organa sensuum" RELATED OMO:0003011 [Wikipedia:Sensory_system]
synonym: "sense organ subsystem" EXACT []
synonym: "sense organs" EXACT [FMA:75259]
synonym: "sense organs set" EXACT [FMA:75259]
synonym: "sensory organ system" RELATED []
synonym: "sensory subsystem" EXACT []
synonym: "sensory systems" EXACT OMO:0003004 [TAO:0000282]
synonym: "set of sense organs" RELATED [FMA:75259]
xref: AAO:0000555
xref: BAMS:SEN
xref: BILA:0000099
xref: EFO:0000805
xref: EHDAA2:0003094
xref: EMAPA:16192
xref: FBbt:00007692 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:75259
xref: MA:0002442
xref: MAT:0000031
xref: MIAA:0000031
xref: NLXANAT:090816
xref: TAO:0000282
xref: VHOG:0001674
xref: Wikipedia:Sensory_system
xref: XAO:0003194
xref: ZFA:0000282
is_a: UBERON:0015203 ! non-connected functional system
relationship: capable_of_part_of GO:0007600 ! sensory perception
relationship: overlaps UBERON:0001016 ! nervous system
relationship: part_of UBERON:0004456 ! entire sense organ system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png" xsd:anyURI
property_value: UBPROP:0000003 "An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001674", ontology="VHOG", source="DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs" xsd:string

[Term]
id: UBERON:0001040
name: yolk sac
namespace: uberon
def: "A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]." [Wikipedia:Yolk_sac]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "saccus vitellinus" RELATED OMO:0003011 [Wikipedia:Yolk_sac]
synonym: "vesicula umbilicalis" RELATED OMO:0003011 [Wikipedia:Yolk_sac]
xref: BTO:0001471
xref: CALOHA:TS-1130
xref: EFO:0003078
xref: EHDAA2:0002212
xref: EHDAA:164
xref: EMAPA:16085
xref: FMA:87180
xref: GAID:1301
xref: MESH:D015017
xref: NCIT:C14128
xref: SCTID:362845002
xref: UMLS:C0043425 {source="ncithesaurus:Yolk_Sac"}
xref: VHOG:0000830
xref: Wikipedia:Yolk_sac
is_a: UBERON:0005292 ! extraembryonic tissue
is_a: UBERON:0005631 {seeAlso="https://github.com/obophenotype/uberon/issues/635"} ! extraembryonic membrane
is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
relationship: has_developmental_contribution_from UBERON:0000925 {source="ISBN:0073040584"} ! endoderm
relationship: has_developmental_contribution_from UBERON:0004872 {source="ISBN:0073040584"} ! splanchnic layer of lateral plate mesoderm
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/17/Gray22.png" xsd:anyURI
property_value: editor_note "consider splitting class" xsd:string
property_value: UBPROP:0000001 "One of the extraembryonic fetal membranes that balloons out from the fetal midgut. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/yolk+sac"}
property_value: UBPROP:0000001 "the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells" xsd:string {source="MP:0001718"}
property_value: UBPROP:0000003 "Structures homologous to the four extraembryonic membranes of reptiles and birds appear in mammals: amnion, chorion, yolk sac, and allantois.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000830", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.187", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In therians, a structure homologous to the yolk sac is is present, but contains no yolk platelets. Instead it is filled with fluid [ISBN:0073040584 (Vertebrates, Kardong)]" xsd:string

[Term]
id: UBERON:0001041
name: foregut
namespace: uberon
def: "Anterior subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165]
subset: developmental_classification
subset: pheno_slim
subset: uberon_slim
synonym: "praeenteron" RELATED OMO:0003011 [Wikipedia:Foregut]
synonym: "proenteron" RELATED OMO:0003011 [Wikipedia:Foregut]
xref: AAO:0011042
xref: BILA:0000085
xref: BTO:0000507
xref: EHDAA2:0000557
xref: EHDAA:520
xref: EMAPA:16548
xref: FBbt:00005379 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45616
xref: MA:0001526
xref: NCIT:C34180
xref: SCTID:361409009
xref: TGMA:0001014
xref: UMLS:C0231051 {source="ncithesaurus:Foregut"}
xref: VHOG:0000285
xref: Wikipedia:Foregut
xref: XAO:0000232
is_a: UBERON:0004921 ! subdivision of digestive tract
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure" xsd:string
property_value: UBPROP:0000001 "The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder." xsd:string {source="MP:0000474"}
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000285", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001042
name: chordate pharynx
namespace: uberon
def: "A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]." [http://www.feedexp.org]
comment: Consider generalizing to deuterostome pharynx
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "pharynx" BROAD SENSU [FMA:46688]
xref: AAO:0000967
xref: BTO:0001049
xref: CALOHA:TS-0785
xref: EFO:0000836
xref: EHDAA2:0001458
xref: EHDAA:2947
xref: EMAPA:16706
xref: EV:0100065
xref: FMA:46688
xref: GAID:155
xref: galen:Pharynx
xref: MA:0000432
xref: MESH:D010614
xref: NCIT:C12425
xref: SCTID:181211006
xref: TAO:0000056
xref: UMLS:C0031354 {source="ncithesaurus:Pharynx"}
xref: VHOG:0000462
xref: Wikipedia:Pharynx
xref: XAO:0003227
xref: ZFA:0000056
is_a: UBERON:0006562 ! pharynx
relationship: continuous_with UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus
relationship: develops_from UBERON:0009145 {source="EHDAA2"} ! pharyngeal region of foregut
relationship: distally_connected_to UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus
relationship: has_skeleton UBERON:0008895 {gci_relation="part_of", gci_filler="NCBITaxon:89593"} ! splanchnocranium
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
relationship: part_of UBERON:0001004 ! respiratory system
property_value: UBPROP:0000001 "A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867]." xsd:string {source="MESH:A03.867"}
property_value: UBPROP:0000001 "Anatomical cavity bounded by the derivatives of the branchial arches.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000001 "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000056", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000001 "Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576]." xsd:string {source="ZFIN:ZDB-PUB-961014-576"}
property_value: UBPROP:0000001 "The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000462", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000002 "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO"}
property_value: UBPROP:0000002 "relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000967", ontology="AAO"}
property_value: UBPROP:0000003 "(...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000462", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) Box essay 13.1 and Box figure I, p.502-503", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0001043
name: esophagus
namespace: uberon
def: "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." [http://www.rivm.nl/interspeciesinfo/inter/oesophagus/, Wikipedia:Esophagus]
subset: efo_slim
subset: human_reference_atlas
subset: major_organ
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "gullet" EXACT []
synonym: "oesophagus" EXACT []
xref: AAO:0000145
xref: ANISEED:1235301
xref: BTO:0000959
xref: CALOHA:TS-0700
xref: EFO:0000835
xref: EHDAA2:0001285
xref: EHDAA:2937
xref: EMAPA:16833
xref: EV:0100069
xref: FMA:7131
xref: GAID:291
xref: galen:Esophagus
xref: MA:0000352
xref: MAT:0000048
xref: MESH:D004947
xref: MIAA:0000048
xref: NCIT:C12389
xref: SCTID:181245004
xref: TAO:0000204
xref: UMLS:C0014876 {source="ncithesaurus:Esophagus"}
xref: VHOG:0000450
xref: Wikipedia:Esophagus
xref: XAO:0000127
xref: ZFA:0000204
is_a: UBERON:0004921 ! subdivision of digestive tract
is_a: UBERON:0005178 ! thoracic cavity element
is_a: UBERON:0013765 ! digestive system element
relationship: develops_from UBERON:0001041 ! foregut
relationship: distally_connected_to UBERON:0000945 {gci_relation="part_of", gci_filler="NCBITaxon:40674", notes="only in species that have a stomach"} ! stomach
relationship: part_of RO:0002577 ! system
relationship: part_of UBERON:0004908 ! upper digestive tract
relationship: proximally_connected_to UBERON:0001042 ! chordate pharynx
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/d/d4/Illu01_head_neck.jpg" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000145", ontology="AAO", source="AAO:EJS"}
property_value: UBPROP:0000003 "The few structural specializations in (adult lampreys) pharynx include complex valves on the external gill openings that direct the tidal flow, and the division of the ancestral pharynx into an oesophagus and a respiratory pharynx.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000450", ontology="VHOG", source="DOI:10.1111/j.1096-3642.1996.tb01658.x Mallatt J, Ventilation and the origin of jawed vertebrates: a new mouth. Zoological Journal of the Linnean Society (1996)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "esophageal" xsd:string
property_value: UBPROP:0000012 "esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995)" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0001045
name: midgut
namespace: uberon
def: "Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]." [GO:0007494, Wikipedia:Midgut]
subset: developmental_classification
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "mesenteron" RELATED OMO:0003011 [Wikipedia:Midgut]
xref: BILA:0000086
xref: BTO:0000863
xref: EFO:0001950
xref: EHDAA2:0001185
xref: EHDAA:983
xref: EMAPA:16255
xref: FBbt:00005383 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45617
xref: MA:0001564
xref: NCIT:C34210
xref: SCTID:361410004
xref: TGMA:0001036
xref: UMLS:C0231052 {source="ncithesaurus:Midgut"}
xref: VHOG:0000290
xref: Wikipedia:Midgut
xref: XAO:0000103
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: part_of RO:0002577 ! system
relationship: proximally_connected_to UBERON:0001041 ! foregut
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/3/3d/Illu_small_intestine.jpg" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. We may explicitly make this a developmental class" xsd:string
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000290", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000008 "In humans: originates from the foregut at the opening of the bile duct into the duodenum and continues through the small intestine and much of the large intestine until the transition to the hindgut about two-thirds of the way through the transverse colon" xsd:string {source="WP"}
property_value: UBPROP:0000012 "in FMA this represents an embryonic region." xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0001046
name: hindgut
namespace: uberon
def: "The caudalmost subdivision of a digestive tract." [http://orcid.org/0000-0002-6601-2165]
subset: developmental_classification
subset: pheno_slim
subset: uberon_slim
synonym: "metenteron" RELATED OMO:0003011 [Wikipedia:Hindgut]
xref: AAO:0011052
xref: BILA:0000087
xref: BTO:0000510
xref: EHDAA2:0000779
xref: EHDAA:975
xref: EMAPA:16715
xref: FBbt:00005384 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:45618
xref: MA:0001527
xref: NCIT:C34188
xref: SCTID:362856002
xref: TGMA:0001020
xref: UMLS:C0231053 {source="ncithesaurus:Hindgut"}
xref: VHOG:0000459
xref: Wikipedia:Hindgut
xref: XAO:0000104
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0003104 {source="Wikipedia"} ! mesenchyme
relationship: part_of RO:0002577 ! system
relationship: proximally_connected_to UBERON:0001045 ! midgut
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/f/f7/Gray472.png" xsd:anyURI
property_value: editor_note "Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future (vertebrates have some contribution from NC - https://github.com/obophenotype/uberon/wiki/The-neural-crest). We may explicitly make this a developmental class" xsd:string
property_value: UBPROP:0000001 "the caudal portion of the primitive digestive tube of the embryo" xsd:string {source="MP:0008786"}
property_value: UBPROP:0000003 "The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000459", ontology="VHOG", source="ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "in FMA this class has no children. In MA it has a single child hindgut epithelium" xsd:string {external_ontology="FMA"}

[Term]
id: UBERON:0001048
name: primordium
namespace: uberon
def: "Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]." [BTO:0001886, FB:DJS, FB:FBrf0089570, http://flybase.org/reports/FBrf0178740.html]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
synonym: "bud" RELATED []
synonym: "future organ" RELATED []
synonym: "placode" RELATED [FBbt:00005495]
synonym: "primordia" RELATED OMO:0003004 [XAO:0003043]
synonym: "rudiment" RELATED []
xref: AEO:0000171
xref: BTO:0001886
xref: EFO:0001652
xref: EHDAA2:0003171
xref: FBbt:00005495 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:86589
xref: MAT:0000482
xref: NCIT:C34275
xref: UMLS:C0678727 {source="ncithesaurus:Primordium"}
xref: Wikipedia:Primordium
xref: XAO:0003043
is_a: UBERON:0005423 {source="EHDAA2"} ! developing anatomical structure
relationship: part_of UBERON:0000468 ! multicellular organism

[Term]
id: UBERON:0001049
name: neural tube
namespace: uberon
def: "In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]." [Wikipedia:Neural_tube]
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "neural primordium" RELATED []
synonym: "presumptive central nervous system" RELATED []
synonym: "tubus neuralis" RELATED OMO:0003011 [Wikipedia:Neural_tube]
xref: AAO:0010617
xref: BTO:0001057
xref: CALOHA:TS-2371
xref: DHBA:10154
xref: EHDAA2:0001254
xref: EHDAA:2869
xref: EHDAA:908
xref: EMAPA:16164
xref: EMAPA:16757
xref: FMA:293882
xref: MAT:0000069
xref: MESH:D054259 {sssom:mapping_justification="vocab:ManualMappingCuration", sssom:author_id="https://orcid.org/0000-0001-9439-5346", sssom:mapping_provider="https://github.com/biopragmatics/biomappings"}
xref: MIAA:0000069
xref: NCIT:C34226
xref: neuronames:1365
xref: SCTID:362852000
xref: TAO:0001135
xref: UMLS:C0231024 {source="ncithesaurus:Neural_Tube"}
xref: VHOG:0000307
xref: Wikipedia:Neural_tube
xref: XAO:0003204
xref: ZFA:0001135
is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
relationship: develops_from UBERON:0005068 ! neural rod
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png" xsd:anyURI
property_value: UBPROP:0000001 "Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0010617", ontology="AAO", source="AAO:JOR"}
property_value: UBPROP:0000001 "The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="http://bgee.unil.ch/", source="http://medical-dictionary.thefreedictionary.com/neural+tube"}
property_value: UBPROP:0000003 "(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000307", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium" xsd:string {source="GO:0021915"}

[Term]
id: UBERON:0001052
name: rectum
namespace: uberon
def: "The terminal portion of the intestinal tube, terminating with the anus." [http://orcid.org/0000-0002-6601-2165, ISBN:0-683-40008-8, MP:0000492]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "intestinum rectum" RELATED [BTO:0001158]
synonym: "rectal sac" RELATED []
synonym: "terminal portion of intestine" EXACT []
synonym: "terminal portion of large intestine" RELATED []
xref: AAO:0010401
xref: BTO:0001158
xref: CALOHA:TS-1180
xref: EFO:0000848
xref: EHDAA2:0001592
xref: EHDAA:5836
xref: EMAPA:17896
xref: EV:0100081
xref: FMA:14544
xref: GAID:311
xref: galen:Rectum
xref: MA:0000336
xref: MAT:0000050
xref: MESH:D012007
xref: MIAA:0000050
xref: NCIT:C12390
xref: SCTID:181261002
xref: UMLS:C0034896 {source="ncithesaurus:Rectum"}
xref: VHOG:0001751
xref: Wikipedia:Rectum
xref: XAO:0000238
is_a: UBERON:0004921 {order="4", source="cjm"} ! subdivision of digestive tract
relationship: continuous_with UBERON:0001159 ! sigmoid colon
relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine
relationship: distalmost_part_of UBERON:0000059 {source="ISBN:0073040584"} ! large intestine
relationship: part_of UBERON:0000059 {source="MA"} ! large intestine
relationship: part_of UBERON:0006866 ! terminal part of digestive tract
relationship: part_of UBERON:0012361 {source="EHDAA2"} ! internal anal region
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/7/75/Anorectum.gif" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_F_Intestine_Large.glb" xsd:anyURI
property_value: depiction "https://ccf-ontology.hubmapconsortium.org/objects/v1.2/SBU_M_Intestine_Large.glb" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "The terminal portion of the large intestine between the ileo-pelvic colon and the anus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001751", ontology="VHOG", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000007 "rectal" xsd:string
property_value: UBPROP:0000008 "In the lungfish, sharks and rays the rectum opens into the cloaca which also receives wastes (urine) from the kidneys and material from the reproductive organs. In bony fish the rectum reaches the outside environment through the anus, which is normally situated just in front the urinary and reproductive openings. However in some fish the digestive tract may be curled back on itself, and in the Electric Eel (Electrophorus electricus) the anus is situated in the fish's throat. -- http://www.earthlife.net/fish/digestion.html" xsd:string

[Term]
id: UBERON:0001062
name: anatomical entity
namespace: uberon
def: "Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species." [FMA:62955, http://orcid.org/0000-0001-9114-8737]
subset: common_anatomy
subset: human_subset
subset: mouse_subset
subset: upper_level
xref: AAO:0010841
xref: AEO:0000000
xref: BFO:0000004
xref: BILA:0000000
xref: BIRNLEX:6
xref: CARO:0000000
xref: EHDAA2:0002229
xref: FBbt:10000000 {sssom:mapping_justification="vocab:ManualMappingCuration"}
xref: FMA:62955
xref: HAO:0000000
xref: MA:0000001
xref: NCIT:C12219
xref: TAO:0100000
xref: TGMA:0001822
xref: UMLS:C1515976 {source="ncithesaurus:Anatomic_Structure_System_or_Substance"}
xref: WBbt:0000100
xref: XAO:0000000
xref: ZFA:0100000
is_a: BFO:0000004 ! independent continuant
relationship: part_of UBERON:0003942 {gci_filler="GO:0050975", gci_relation="capable_of_part_of"} ! somatosensory system
relationship: part_of UBERON:0003942 {gci_relation="capable_of_part_of", gci_filler="GO:0019233"} ! somatosensory system
property_value: RO:0002175 NCBITaxon:33090
property_value: RO:0002175 NCBITaxon:33208
property_value: RO:0002175 NCBITaxon:4751

[Term]
id: UBERON:0001064
name: ventral pancreatic duct
namespace: uberon
alt_id: UBERON:0005627
def: "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla." [Wikipedia:Pancreatic_duct]
comment: EDITOR_NOTE in EHDAA2 this is an epithelium, in FMA the wall consists of epithelium and connective tissue
subset: human_reference_atlas
subset: uberon_slim
synonym: "canal of Wirsung" RELATED [BTO:0002362]
synonym: "chief pancreatic duct" EXACT [FMA:16003]
synonym: "duct of Wirsung" EXACT [Wikipedia:Pancreatic_duct]
synonym: "ductus pancreatis ventralis" RELATED []
synonym: "hepaticopancreatic duct" RELATED [BTO:0002362]
synonym: "main pancreatic duct" EXACT [MA:0000126]
synonym: "pancreatic duct" BROAD [MESH:A03.734.667]
xref: BTO:0002362
xref: EHDAA2:0001396
xref: EHDAA:6905
xref: EMAPA:17510
xref: FMA:16003
xref: GAID:337
xref: MA:0000126
xref: MESH:D010183
xref: NCIT:C12272
xref: RETIRED_EHDAA2:0002177
xref: SCTID:245385001
xref: UMLS:C0030288 {source="ncithesaurus:Pancreatic_Duct"}
xref: VHOG:0000256
xref: Wikipedia:Pancreatic_duct
is_a: UBERON:0000025 ! tube
is_a: UBERON:0007329 {source="FMA"} ! pancreatic duct
relationship: channel_for UBERON:0001970 ! bile
relationship: channels_into UBERON:0004913 ! hepatopancreatic ampulla
relationship: continuous_with UBERON:0001174 ! common bile duct
relationship: develops_from UBERON:0003924 {source="EHDAA2"} ! ventral pancreatic bud
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/15/Gray1100.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000003 "These data show that ducts within the zebrafish pancreas originally arise in situ from isolated progenitor cells rather than arising from reiterative branching of the pancreatic epithelium. This process of pancreatic duct formation in zebrafish may be analogous to the mechanism of duct formation in the mammalian mammary and salivary glands. (...) A related mechanism of duct formation has also been proposed to occur within the mammalian pancreatic epithelium.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000256", ontology="VHOG", source="DOI:10.1016/j.ydbio.2005.04.035 Yee NS, Lorent K, Pack M, Exocrine pancreas development in zebrafish. Developmental Biology (2005)", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000011 "Upon reaching its final destination, the ventral pancreatic bud fuses with the much larger dorsal pancreatic bud. At this point of fusion, the main ducts of the ventral and dorsal pancreatic buds fuse, forming the duct of Wirsung, the main pancreatic duct." xsd:string {source="WP"}

[Term]
id: UBERON:0001068
name: skin of back
namespace: uberon
def: "A zone of skin that is part of a back [Automatically generated definition]." [OBOL:automatic]
comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region
subset: pheno_slim
synonym: "back skin" EXACT []
synonym: "back zone of skin" EXACT [OBOL:automatic]
synonym: "skin, dorsal region" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "zone of skin of back" EXACT [OBOL:automatic]
xref: EMAPA:36392
xref: FMA:10462
xref: FMA:22985
xref: MA:0000498
xref: SCTID:181492002
is_a: UBERON:0001085 {source="MA"} ! skin of trunk
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0001137 ! dorsum
relationship: part_of UBERON:0011270 {source="MA"} ! dorsal trunk

[Term]
id: UBERON:0001070
name: external carotid artery
namespace: uberon
def: "A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]." [MGI:anna]
subset: efo_slim
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "arteria carotis externa" RELATED OMO:0003011 [Wikipedia:External_carotid_artery]
synonym: "external carotid" EXACT [AAO:0010218]
xref: AAO:0010218
xref: AAO:0010416
xref: BTO:0004696
xref: EFO:0001953
xref: EHDAA2:0000461
xref: EMAPA:18611
xref: FMA:10635
xref: GAID:480
xref: MA:0001929
xref: MESH:D002342
xref: NCIT:C32551
xref: SCTID:362044002
xref: UMLS:C0007275 {source="ncithesaurus:External_Carotid_Artery"}
xref: VHOG:0000265
xref: Wikipedia:External_carotid_artery
xref: XAO:0000345
is_a: UBERON:0005396 {source="MA"} ! carotid artery segment
relationship: branching_part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches
relationship: develops_from UBERON:0001530 {source="EHDAA2"} ! common carotid artery plus branches
relationship: part_of UBERON:0001530 {source="FMA"} ! common carotid artery plus branches
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/1/13/External_carotid_a.gif" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: seeAlso "https://sourceforge.net/tracker/?func=detail&aid=3486863&group_id=76834&atid=1127722" xsd:anyURI
property_value: UBPROP:0000008 "not homologous to the external carotid of zebrafish (Goodrich, 1958) - http://zfish.nichd.nih.gov/zfatlas/Intro%20Page/comparative.html; check XAO" xsd:string

[Term]
id: UBERON:0001071
name: superficial cervical artery
namespace: uberon
def: "It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery." [Wikipedia:Superficial_part_of_transverse_cervical_artery]
comment: The transverse cervical artery splits into two branches, a superficial one and a deep one[WP]
subset: human_reference_atlas
subset: uberon_slim
synonym: "superficial branch of transverse cervical artery" EXACT [Wikipedia:Superficial_part_of_transverse_cervical_artery]
xref: EMAPA:37117 {source="MA:th"}
xref: FMA:10665
xref: MA:0002052
xref: NCIT:C53005
xref: SCTID:161746006
xref: UMLS:C0226271 {source="ncithesaurus:Superficial_Cervical_Artery"}
xref: Wikipedia:Superficial_part_of_transverse_cervical_artery
is_a: UBERON:0012320 ! cervical artery
intersection_of: UBERON:0012320 ! cervical artery
intersection_of: part_of UBERON:0035549 ! vasculature of integument
relationship: connected_to UBERON:0012324 ! transverse cervical artery
relationship: part_of UBERON:0035549 ! vasculature of integument
property_value: RO:0002175 NCBITaxon:9606

[Term]
id: UBERON:0001072
name: posterior vena cava
namespace: uberon
def: "A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart." [http://orcid.org/0000-0002-6601-2165, Wikipedia:Inferior_vena_cava]
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
synonym: "caudal vena cava" RELATED [VHOG:0001194]
synonym: "inferior caval vein" EXACT [http://orcid.org/0000-0002-6601-2165]
synonym: "inferior vena cava" EXACT [Wikipedia:Venae_cavae]
synonym: "postcava" RELATED []
synonym: "posterior vena cava" EXACT [Wikipedia:Venae_cavae]
synonym: "vena cava inferior" RELATED OMO:0003011 [BTO:0002682, Wikipedia:Inferior_vena_cava]
xref: AAO:0011083
xref: BTO:0002682
xref: EHDAA2:0000611
xref: EMAPA:18416
xref: FMA:10951
xref: GAID:548
xref: galen:InferiorVenaCava
xref: MA:0000480
xref: MESH:D014682
xref: NCIT:C12815
xref: SCTID:181369003
xref: UMLS:C0042458 {source="ncithesaurus:Inferior_Vena_Cava"}
xref: VHOG:0001194
xref: Wikipedia:Inferior_vena_cava
xref: XAO:0000388
is_a: UBERON:0004087 ! vena cava
intersection_of: UBERON:0004087 ! vena cava
intersection_of: drains UBERON:0000154 ! posterior region of body
disjoint_from: UBERON:0001585 {source="lexical"} ! anterior vena cava
relationship: channels_into UBERON:0002078 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! right cardiac atrium
relationship: connected_to UBERON:0002078 ! right cardiac atrium
relationship: develops_from UBERON:0005487 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="Wikipedia:Vitelline_vein"} ! vitelline vein
relationship: drains UBERON:0000154 ! posterior region of body
relationship: part_of RO:0002577 ! system
property_value: depiction "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray577.png" xsd:anyURI
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Trunk of systemic vein which is formed by the union of the right common iliac vein and the left common iliac vein and terminates in the right atrium[FMA]." xsd:string {source="FMA:10951"}
property_value: UBPROP:0000003 "Phylogenetic modifications within this basic pattern of arteries and veins are largely correlated with functional changes. In the transition from water to land, gills gave way to lungs, accompanied by the establishment of a pulmonary circulation. In some fishes and certainly in tetrapods, the cardinal veins become less involved in blood return. Instead, the composite, prominent postcava (posterior vena cava) arose to drain the posterior part of the body and the precava (anterior vena cava) developed to drain the anterior part of the body.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001194", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.454-455", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001073
name: ileocecal junction
namespace: uberon
def: "A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice." [http://www.medilexicon.com/medicaldictionary.php?t=46539]
synonym: "ileocaecal junction" EXACT []
xref: EMAPA:37601 {source="MA:th"}
xref: FMA:11338
xref: MA:0000332
xref: SCTID:264021000
is_a: UBERON:8410024 ! intestinal junction
intersection_of: UBERON:0007651 ! anatomical junction
intersection_of: connects UBERON:0000059 ! large intestine
intersection_of: connects UBERON:0002108 ! small intestine
relationship: connects UBERON:0000059 ! large intestine
relationship: connects UBERON:0002108 ! small intestine
relationship: only_in_taxon NCBITaxon:7742 ! Vertebrata <vertebrates>

[Term]
id: UBERON:0001074
name: pericardial cavity
namespace: uberon
def: "A potential space between the visceral and parietal layers of the pericardium." [Wikipedia:Pericardium]
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "cavitas pericardiaca" RELATED OMO:0003011 [Wikipedia:Pericardial_cavity]
synonym: "cavity of pericardial sac" EXACT []
synonym: "pericardial space" EXACT [Wikipedia:Pericardial_cavity]
xref: BSA:0000091
xref: EHDAA2:0001434
xref: EMAPA:16131
xref: EMAPA:16132
xref: FMA:11350
xref: galen:PericardialSpace
xref: MA:0000053
xref: NCIT:C38662
xref: SCTID:362027001
xref: TAO:0002220
xref: UMLS:C0225972 {source="ncithesaurus:Pericardial_Cavity"}
xref: VHOG:0000556
xref: Wikipedia:Pericardial_cavity
xref: ZFA:0001655
is_a: UBERON:0002323 {source="MA"} ! coelemic cavity lumen
is_a: UBERON:0035809 ! serous cavity
intersection_of: UBERON:0002553 ! anatomical cavity
intersection_of: luminal_space_of UBERON:0002406 ! pericardial sac
relationship: develops_from UBERON:0003887 {source="Wikipedia"} ! intraembryonic coelom
relationship: location_of UBERON:0002409 ! pericardial fluid
relationship: luminal_space_of UBERON:0002406 ! pericardial sac
relationship: part_of UBERON:0002406 {source="FMA"} ! pericardial sac
relationship: surrounded_by UBERON:0002357 ! serous pericardium
property_value: UBPROP:0000001 "Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002220", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000556", ontology="VHOG", source="ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206", source="http://bgee.unil.ch/"}
property_value: UBPROP:0000012 "check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal)" xsd:string {external_ontology="ZFA"}

[Term]
id: UBERON:0001081
name: endocardium of ventricle
namespace: uberon
def: "Endocardium that is part of the cardiac ventricle." [ZFIN:curator]
subset: pheno_slim
subset: vertebrate_core
synonym: "cardiac ventricle endocardium" EXACT [OBOL:automatic]
synonym: "endocardium of cardiac ventricle" EXACT [OBOL:automatic]
synonym: "endocardium of heart ventricle" EXACT [OBOL:automatic]
synonym: "endocardium of lower chamber of heart" EXACT [OBOL:automatic]
synonym: "endocardium of ventricle of heart" EXACT [OBOL:automatic]
synonym: "heart ventricle endocardium" EXACT [OBOL:automatic]
synonym: "lower chamber of heart endocardium" EXACT [OBOL:automatic]
synonym: "ventricle endocardial tissue" RELATED [VHOG:0000607]
synonym: "ventricle endocardium" EXACT []
synonym: "ventricle of heart endocardium" EXACT [OBOL:automatic]
synonym: "ventricular endocardium" EXACT []
xref: EMAPA:32747
xref: FMA:12148
xref: MA:0000079
xref: SCTID:192172004
xref: TAO:0002247
xref: VHOG:0000607
xref: ZFA:0001615
is_a: UBERON:0000487 ! simple squamous epithelium
is_a: UBERON:0002165 ! endocardium
is_a: UBERON:0012275 ! meso-epithelium
intersection_of: UBERON:0002165 ! endocardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: contributes_to_morphology_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! heart ventricle wall

[Term]
id: UBERON:0001082
name: epicardium of ventricle
namespace: uberon
def: "An epicardial layer that lines a cardiac ventricle." [http://orcid.org/0000-0002-6601-2165]
subset: vertebrate_core
synonym: "cardiac ventricle epicardium" EXACT [OBOL:automatic]
synonym: "ventricular epicardium" EXACT []
xref: FMA:12150
xref: TAO:0005058
xref: ZFA:0005058
is_a: UBERON:0002348 ! epicardium
intersection_of: UBERON:0002348 ! epicardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0002082 ! cardiac ventricle
property_value: UBPROP:0000001 "The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005058", ontology="TAO", source="ZFIN:curator"}

[Term]
id: UBERON:0001083
name: myocardium of ventricle
namespace: uberon
def: "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer." [ZFIN:curator]
subset: efo_slim
subset: pheno_slim
subset: vertebrate_core
synonym: "ventricle cardiac muscle" RELATED [VHOG:0000604]
synonym: "ventricle myocardium" EXACT []
synonym: "ventricular myocardium" EXACT []
xref: EFO:0003088
xref: EMAPA:32748
xref: FMA:12151
xref: MA:0000082
xref: SCTID:192084000
xref: TAO:0005061
xref: VHOG:0000604
xref: ZFA:0005061
is_a: UBERON:0002349 ! myocardium
intersection_of: UBERON:0002349 ! myocardium
intersection_of: part_of UBERON:0002082 ! cardiac ventricle
relationship: contributes_to_morphology_of UBERON:0002082 ! cardiac ventricle
relationship: part_of UBERON:0004784 {source="https://github.com/obophenotype/uberon/wiki/Inferring-part-of-relationships"} ! heart ventricle wall
property_value: UBPROP:0000001 "Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005061", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000003 "As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000604", ontology="VHOG", source="ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481", source="http://bgee.unil.ch/"}

[Term]
id: UBERON:0001084
name: skin of head
namespace: uberon
def: "A zone of skin that is part of a head [Automatically generated definition]." [OBOL:automatic]
comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region
synonym: "adult head zone of skin" EXACT [OBOL:automatic]
synonym: "head skin" EXACT []
synonym: "head zone of skin" EXACT [OBOL:automatic]
synonym: "zone of skin of adult head" EXACT [OBOL:automatic]
synonym: "zone of skin of head" EXACT [OBOL:automatic]
xref: FMA:12166
xref: FMA:24756
xref: MA:0000582
xref: NCIT:C52757
xref: SCTID:181484006
xref: UMLS:C0205029 {source="ncithesaurus:Head_Skin"}
is_a: UBERON:0012180 ! head or neck skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0000033 ! head
relationship: part_of UBERON:0000033 ! head

[Term]
id: UBERON:0001085
name: skin of trunk
namespace: uberon
def: "A zone of skin that is part of a trunk [Automatically generated definition]." [OBOL:automatic]
comment: EDITOR_NOTE TODO - distinguish between entire skin of region and arbitrary zone of skin on region
synonym: "torso zone of skin" EXACT [OBOL:automatic]
synonym: "trunk skin" EXACT []
synonym: "trunk zone of skin" EXACT [OBOL:automatic]
synonym: "zone of skin of torso" EXACT [OBOL:automatic]
synonym: "zone of skin of trunk" EXACT [OBOL:automatic]
xref: EMAPA:37278 {source="MA:th"}
xref: FMA:12167
xref: FMA:23093
xref: MA:0000517
xref: NCIT:C12295
xref: SCTID:181489001
xref: UMLS:C0205031 {source="ncithesaurus:Skin_of_the_Trunk"}
is_a: UBERON:0000014 ! zone of skin
intersection_of: UBERON:0000014 ! zone of skin
intersection_of: part_of UBERON:0002100 ! trunk
relationship: part_of UBERON:0002100 ! trunk

[Term]
id: UBERON:0001087
name: pleural fluid
namespace: uberon
def: "Transudate contained in the pleural cavity." [FMA:12273]
subset: uberon_slim
xref: BTO:0003080
xref: FMA:12273
xref: MA:0002532
xref: MAT:0000500
xref: ncithesaurus:Pleural_Fluid
xref: Wikipedia:Pleural_fluid
is_a: UBERON:0036244 ! secretion of serous membrane
intersection_of: UBERON:0007779 ! transudate
intersection_of: located_in UBERON:0002402 ! pleural cavity
relationship: located_in UBERON:0002402 ! pleural cavity

[Term]
id: UBERON:0001088
name: urine
namespace: uberon
def: "Excretion that is the output of a kidney." [https://github.com/geneontology/go-ontology/issues/11025, Wikipedia:Urine]
subset: efo_slim
subset: pheno_slim
subset: uberon_slim
xref: BTO:0001419
xref: CALOHA:TS-1092
xref: EFO:0001939
xref: EMAPA:36554
xref: ENVO:00002047
xref: FMA:12274
xref: GAID:1189
xref: galen:Urine
xref: MA:0002545
xref: MAT:0000058
xref: MESH:D014556
xref: MIAA:0000058
xref: NCIT:C13283
xref: UMLS:C0042036 {source="ncithesaurus:Urine"}
xref: Wikipedia:Urine
is_a: UBERON:0000174 ! excreta
intersection_of: UBERON:0000174 ! excreta
intersection_of: produced_by UBERON:0002113 ! kidney
relationship: has_quality PATO:0001548 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! quality of a liquid
relationship: produced_by UBERON:0002113 ! kidney
property_value: UBPROP:0000008 "kidney excreta from some taxa (e.g. in aves) may not be liquid" xsd:string

[Term]
id: UBERON:0001090
name: synovial fluid
namespace: uberon
def: "Joint fluid is a transudate of plasma that is actively secreted by synovial cells." [https://www.ncbi.nlm.nih.gov/books/NBK274/]
subset: uberon_slim
subset: vertebrate_core
synonym: "joint fluid" EXACT [https://www.ncbi.nlm.nih.gov/books/NBK274/]
xref: BTO:0001339
xref: CALOHA:TS-0996
xref: ENVO:02000039
xref: FMA:12277
xref: GAID:265
xref: galen:SynovialFluid
xref: MA:0002544
xref: MESH:D013582
xref: NCIT:C33718
xref: TAO:0005154
xref: UMLS:C0039097 {source="ncithesaurus:Synovial_Fluid"}
xref: Wikipedia:Synovial_fluid
xref: ZFA:0005154
is_a: UBERON:0007779 ! transudate
is_a: UBERON:0007794 {source="FMA"} ! secretion of serous gland
intersection_of: UBERON:0007779 ! transudate
intersection_of: produced_by CL:0000214 ! synovial cell
relationship: has_part CHEBI:16336 ! hyaluronic acid
relationship: located_in UBERON:0007617 ! synovial cavity of joint
relationship: produced_by CL:0000214 ! synovial cell
property_value: UBPROP:0000001 "Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0005154", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000009 "It provides nutrients and lubrication for articular cartilage" xsd:string
property_value: UBPROP:0000010 "The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma" xsd:string

[Term]
id: UBERON:0001092
name: vertebral bone 1
namespace: uberon
def: "The first vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "atlas" EXACT []
synonym: "atlas (CI)" EXACT []
synonym: "atlas [C I]" EXACT OMO:0003011 [FMA:12519, FMA:TA]
synonym: "atlas vertebra" EXACT []
synonym: "C1" BROAD []
synonym: "C1 vertebra" EXACT []
synonym: "cervical atlas" EXACT [MP:0011576]
synonym: "cervical vertebra 1" EXACT HUMAN_PREFERRED [MA:0001421]
synonym: "first cervical vertebra" EXACT []
synonym: "vertebra 1" EXACT [TAO:0001167]
xref: AAO:0000709
xref: EHDAA:10606
xref: EMAPA:19431
xref: FMA:12519
xref: GAID:236
xref: MA:0001421
xref: MESH:D001270
xref: NCIT:C32239
xref: SCTID:181818007
xref: TAO:0001167
xref: UMLS:C0004170 {source="ncithesaurus:C1_Vertebra"}
xref: Wikipedia:Atlas_(anatomy)
xref: ZFA:0001167
is_a: UBERON:0002412 ! vertebra
relationship: anterior_to UBERON:0001093 ! vertebral bone 2
relationship: anteriorly_connected_to UBERON:0001676 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="FMA"} ! occipital bone
relationship: part_of UBERON:0006072 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! cervical region of vertebral column
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "First postcranial vertebra, which is modified anteriorly to articulate with the skull.[AAO]" xsd:string {date_retrieved="2012-06-20", external_class="AAO:0000709", ontology="AAO", source="AAO:Duellman_and_Trueb_1994"}
property_value: UBPROP:0000001 "Vertebra that is posteriorly adjacent to the neurocranium.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001167", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000107 "1" xsd:nonNegativeInteger

[Term]
id: UBERON:0001093
name: vertebral bone 2
namespace: uberon
def: "The second vertebral bone in the vertebral column." [http://orcid.org/0000-0002-6601-2165]
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "axis" RELATED INCONSISTENT [MA:0001422]
synonym: "axis (CII)" EXACT []
synonym: "axis [C II]" EXACT OMO:0003011 [FMA:12520, FMA:TA]
synonym: "axis vertebra" EXACT []
synonym: "C2" RELATED []
synonym: "C2 vertebra" NARROW []
synonym: "cervical axis" EXACT [MP:0004608]
synonym: "cervical vertebra 2" NARROW HUMAN_PREFERRED [MA:0001422]
synonym: "second cervical vertebra" NARROW []
synonym: "vertebra 2" EXACT [ZFA:0001168]
xref: EHDAA:10608
xref: EMAPA:19432
xref: FMA:12520
xref: GAID:237
xref: MA:0001422
xref: MESH:D001368
xref: NCIT:C32240
xref: SCTID:181819004
xref: TAO:0001168
xref: UMLS:C0004457 {source="ncithesaurus:C2_Vertebra"}
xref: Wikipedia:Axis_(anatomy)
xref: ZFA:0001168
is_a: UBERON:0002412 ! vertebra
relationship: anteriorly_connected_to UBERON:0001092 {source="FMA"} ! vertebral bone 1
relationship: part_of RO:0002577 ! system
relationship: part_of UBERON:0006072 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! cervical region of vertebral column
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Vertebra that is posteriorly adjacent to vertebra 1.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001168", ontology="TAO", source="TAO:wd"}
property_value: UBPROP:0000013 "not the same as ZFA term 'axis'" xsd:string
property_value: UBPROP:0000107 "2" xsd:nonNegativeInteger

[Term]
id: UBERON:0001095
name: caudal vertebra
namespace: uberon
alt_id: UBERON:0006070
def: "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx)." [http://orcid.org/0000-0002-6601-2165]
comment: Taxon notes In zebrafish, Vertebra bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae
subset: human_reference_atlas
subset: pheno_slim
subset: uberon_slim
subset: vertebrate_core
synonym: "caudal vertebra" BROAD SENSU [FMA:12527]
synonym: "caudal vertebrae" EXACT OMO:0003004 []
synonym: "caudal vertebral bone" EXACT []
synonym: "caudal vertebral bone element" EXACT []
synonym: "coccygea" RELATED [MA:0001420]
synonym: "coccygeal segment" EXACT []
synonym: "coccygeal vertebra" EXACT [FMA:12527]
synonym: "fused tail vertebra" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "tail vertebra" RELATED [MA:0000310]
xref: EMAPA:18374
xref: FMA:12527
xref: galen:CoccygealVertebra
xref: MA:0000310
xref: MA:0001420
xref: NCIT:C32334
xref: SCTID:361774004
xref: TAO:0000326
xref: UMLS:C0223616 {source="ncithesaurus:Coccygeal_Vertebra"}
xref: Wikipedia:Caudal_vertebra
xref: XAO:0003079
xref: ZFA:0000326
is_a: UBERON:0002412 ! vertebra
is_a: UBERON:0004247 ! bone of dorsum
is_a: UBERON:0018142 ! caudal vertebra endochondral element
intersection_of: UBERON:0018142 ! caudal vertebra endochondral element
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
property_value: RO:0002175 NCBITaxon:9606
property_value: UBPROP:0000001 "Vertebrae bearing a hemal arch and spine. The most posterior caudal vertebrae support the caudal fin and are referred to as preural vertebrae.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0000326", ontology="TAO", source="ZFIN:curator"}
property_value: UBPROP:0000012 "we deliberately merge the MA classes as we believe them equivalent" xsd:string {external_ontology="MA"}

[Term]
id: UBERON:0001096
name: wall of esophagus
namespace: uberon
def: "An anatomical wall that is part of a esophagus [Automatically generated definition]." [OBOL:automatic]
synonym: "anatomical wall of esophagus" EXACT [OBOL:automatic]
synonym: "anatomical wall of gullet" EXACT [OBOL:automatic]
synonym: "anatomical wall of oesophagus" EXACT [OBOL:automatic]
synonym: "esophageal wall" EXACT []
synonym: "esophagus anatomical wall" EXACT [OBOL:automatic]
synonym: "esophagus wall" EXACT []
synonym: "gullet anatomical wall" EXACT [OBOL:automatic]
synonym: "gullet wall" EXACT [OBOL:automatic]
synonym: "oesophagus anatomical wall" EXACT [OBOL:automatic]
synonym: "oesophagus wall" EXACT [OBOL:automatic]
synonym: "wall of gullet" EXACT [OBOL:automatic]
synonym: "wall of oesophagus" EXACT [OBOL:automatic]
xref: EMAPA:35326
xref: FMA:12611
xref: MA:0002691
is_a: UBERON:0000328 ! gut wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0001043 ! esophagus
relationship: part_of UBERON:0001043 ! esophagus

[Term]
id: UBERON:0001103
name: diaphragm
namespace: uberon
def: "A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control." [MP:0002279]
subset: efo_slim
subset: organ_slim
subset: pheno_slim
subset: uberon_slim
synonym: "diaphragm muscle" EXACT [BTO:0000341]
synonym: "diaphragm of thorax" EXACT []
synonym: "midriff" RELATED [BTO:0000341]
synonym: "phren" RELATED [BTO:0000341]
synonym: "thoracic diaphragm" EXACT []
xref: BTO:0000341
xref: CALOHA:TS-0198
xref: EFO:0000937
xref: EHDAA2:0003495
xref: EMAPA:17701
xref: EV:0100376
xref: FMA:13295
xref: GAID:158
xref: MA:0001904
xref: MAT:0000502
xref: MESH:D003964
xref: NCIT:C12702
xref: SCTID:181614006
xref: UMLS:C0011980 {source="ncithesaurus:Diaphragm"}
xref: VHOG:0000713
xref: Wikipedia:Thoracid_diaphragm
is_a: UBERON:0003830 ! thoracic segment muscle
is_a: UBERON:0003831 ! respiratory system muscle
relationship: develops_from UBERON:0010084 ! future diaphragm
relationship: immediate_transformation_of UBERON:0010084 {evidence="definitional"} ! future diaphragm
relationship: innervated_by UBERON:0001884 ! phrenic nerve
relationship: only_in_taxon NCBITaxon:40674 {source="PMID:23586979"} ! Mammalia
property_value: RO:0002161 NCBITaxon:8782 {source="Wikipedia:Thoracic_diaphragm#Comparative_anatomy_and_evolution"}
property_value: UBPROP:0000001 "The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs[GO]." xsd:string {source="GO:0060539"}
property_value: UBPROP:0000003 "The mammals are characterized by a diaphragm, which separates the thoracic portion of the body cavity from the abdominal region and assists in drawing air into the lungs and forcing it out. Modern reptiles lack a muscu