LOCUS Human Mitochondrion 16569 bp DNA circular PRI 31-OCT-2014 DEFINITION Homo sapiens mitochondrion, complete genome. ACCESSION NC_012920 AC_000021 VERSION NC_012920.1 GI:251831106 DBLINK BioProject: PRJNA30353 KEYWORDS RefSeq. SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16569) AUTHORS Andrews,R.M., Kubacka,I., Chinnery,P.F., Lightowlers,R.N., Turnbull,D.M. and Howell,N. TITLE Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA JOURNAL Nat. Genet. 23 (2), 147 (1999) PUBMED 10508508 REFERENCE 2 (bases 324 to 743) AUTHORS Andrews,R.M., Kubacka,I., Chinnery,P.F., Lightowlers,R.N., Turnbull,D.M. and Howell,N. TITLE Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA JOURNAL Nat. Genet. 23 (2), 147 (1999) PUBMED 10508508 REFERENCE 3 (bases 1 to 16569) AUTHORS Anderson,S., Bankier,A.T., Barrell,B.G., de Bruijn,M.H., Coulson,A.R., Drouin,J., Eperon,I.C., Nierlich,D.P., Roe,B.A., Sanger,F., Schreier,P.H., Smith,A.J., Staden,R. and Young,I.G. TITLE Sequence and organization of the human mitochondrial genome JOURNAL Nature 290 (5806), 457-465 (1981) PUBMED 7219534 REFERENCE 4 (bases 15888 to 15954) AUTHORS Anderson,S., Bankier,A.T., Barrell,B.G., de Bruijn,M.H., Coulson,A.R., Drouin,J., Eperon,I.C., Nierlich,D.P., Roe,B.A., Sanger,F., Schreier,P.H., Smith,A.J., Staden,R. and Young,I.G. TITLE Sequence and organization of the human mitochondrial genome JOURNAL Nature 290 (5806), 457-465 (1981) PUBMED 7219534 REFERENCE 5 (bases 1 to 16569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (08-JUL-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 6 (bases 1 to 16569) AUTHORS Kogelnik,A.M. and Lott,M.T. TITLE Direct Submission JOURNAL Submitted (24-AUG-2006) Mitomap.org, Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG) University of California, University of California, Irvine, Irvine, CA 92697-3940, USA REMARK Sequence update by submitter REFERENCE 7 (bases 1 to 16569) AUTHORS Kogelnik,A.M. and Lott,M.T. TITLE Direct Submission JOURNAL Submitted (18-APR-1997) Center for Molecular Medicine, Emory University School of Medicine, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA REMARK sequence updated COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J01415. On Jul 8, 2009 this sequence version replaced gi:115315570. This sequence is a corrected version of the HUMMTCG reference sequence. The original Cambridge reference sequence (CRS) is preserved as GenBank J01415 gi:337188 [PMID:7219534]. Corrections have been made and annotated per the re-sequencing of the original material by Andrews et al [PMID:10508508]. This Revised Cambridge Reference Sequence (rCRS) has eighteen specific corrections or confirmations of the original 1981 sequence of Anderson et al [PMID:7219534]. Seven nucleotides are confirmed as rare polymorphisms, maintained as: 263A, 311C-315C, 750A, 1438A, 4769A, 8860A, and 15326A. Eleven nucleotides are error corrections: 3107del, 3423T, 4985A, 9559C, 11335C, 13702C, 14199T, 14272C, 14365C, 14368C, and 14766C. These 11 errors in the original Cambridge sequence were determined to be either outright sequencing errors (8 instances) or due to the presence of bovine DNA (2 instances) or HeLa DNA (1 instance) mixed in with the original human placental DNA [PMID:10508508]. HISTORICAL NUCLEOTIDE NUMBERS ARE MAINTAINED by indicating 3107del as 'N'. A summary table of the reanalysis data is available online at http://www.mitomap.org/MITOMAP/CambridgeReanalysis L-strand is shown. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..16569 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /isolation_source="caucasian" /db_xref="taxon:9606" /tissue_type="placenta" /country="United Kingdom: Great Britain" /note="this is the rCRS" D-loop complement(join(16024..16569,1..576)) gene 577..647 /gene="TRNF" /nomenclature="Official Symbol: MT-TF | Name: mitochondrially encoded tRNA phenylalanine | Provided by: HGNC:HGNC:7481" /db_xref="GeneID:4558" /db_xref="HGNC:HGNC:7481" /db_xref="MIM:590070" tRNA 577..647 /gene="TRNF" /product="tRNA-Phe" /note="NAR: 1455" /anticodon=(pos:611..613,aa:Phe,seq:gaa) /codon_recognized="UUC" /db_xref="GeneID:4558" /db_xref="HGNC:HGNC:7481" /db_xref="MIM:590070" gene 648..1601 /gene="RNR1" /gene_synonym="MTRNR1" /nomenclature="Official Symbol: MT-RNR1 | Name: mitochondrially encoded 12S RNA | Provided by: HGNC:HGNC:7470" /db_xref="GeneID:4549" /db_xref="HGNC:HGNC:7470" /db_xref="MIM:561000" rRNA 648..1601 /gene="RNR1" /gene_synonym="MTRNR1" /product="s-rRNA" /note="12S rRNA; 12S ribosomal RNA" /db_xref="GeneID:4549" /db_xref="HGNC:HGNC:7470" /db_xref="MIM:561000" STS 1478..2187 /standard_name="PMC316374P5" /db_xref="UniSTS:272966" gene 1602..1670 /gene="TRNV" /gene_synonym="MTTV" /nomenclature="Official Symbol: MT-TV | Name: mitochondrially encoded tRNA valine | Provided by: HGNC:HGNC:7500" /db_xref="GeneID:4577" /db_xref="HGNC:HGNC:7500" /db_xref="MIM:590105" tRNA 1602..1670 /gene="TRNV" /gene_synonym="MTTV" /product="tRNA-Val" /note="NAR: 2053" /anticodon=(pos:1633..1635,aa:Val,seq:tac) /codon_recognized="GUA" /db_xref="GeneID:4577" /db_xref="HGNC:HGNC:7500" /db_xref="MIM:590105" gene 1671..3229 /gene="RNR2" /gene_synonym="MTRNR2" /nomenclature="Official Symbol: MT-RNR2 | Name: mitochondrially encoded 16S RNA | Provided by: HGNC:HGNC:7471" /db_xref="GeneID:4550" /db_xref="HGNC:HGNC:7471" /db_xref="MIM:561010" rRNA 1671..3229 /gene="RNR2" /gene_synonym="MTRNR2" /product="l-rRNA" /note="16S ribosomal RNA; 16S rRNA" /db_xref="GeneID:4550" /db_xref="HGNC:HGNC:7471" /db_xref="MIM:561010" STS 2062..2203 /gene="RNR2" /gene_synonym="MTRNR2" /standard_name="D3S2893E" /db_xref="UniSTS:150884" STS 2712..2884 /gene="RNR2" /gene_synonym="MTRNR2" /standard_name="NIB250" /db_xref="UniSTS:56529" STS 2806..2946 /gene="RNR2" /gene_synonym="MTRNR2" /standard_name="PMC31832P1" /db_xref="UniSTS:273091" misc_feature 3107 /note="preserves historical genome annotation numbering" gene 3230..3304 /gene="TRNL1" /gene_synonym="MTTL1" /nomenclature="Official Symbol: MT-TL1 | Name: mitochondrially encoded tRNA leucine 1 (UUA/G) | Provided by: HGNC:HGNC:7490" /db_xref="GeneID:4567" /db_xref="HGNC:HGNC:7490" /db_xref="MIM:590050" tRNA 3230..3304 /gene="TRNL1" /gene_synonym="MTTL1" /product="tRNA-Leu" /note="NAR: 1054" /anticodon=(pos:3265..3267,aa:Leu,seq:taa) /codon_recognized="UUR" /db_xref="GeneID:4567" /db_xref="HGNC:HGNC:7490" /db_xref="MIM:590050" gene 3307..4262 /gene="ND1" /gene_synonym="MTND1" /nomenclature="Official Symbol: MT-ND1 | Name: mitochondrially encoded NADH dehydrogenase 1 | Provided by: HGNC:HGNC:7455" /db_xref="GeneID:4535" /db_xref="HGNC:HGNC:7455" /db_xref="MIM:516000" CDS 3307..4262 /gene="ND1" /gene_synonym="MTND1" /note="NADH dehydrogenase, subunit 1 (complex I); TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:4261..4262,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 1" /protein_id="YP_003024026.1" /db_xref="GI:251831107" /db_xref="GeneID:4535" /db_xref="HGNC:HGNC:7455" /db_xref="MIM:516000" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" STS 3740..3834 /gene="ND1" /gene_synonym="MTND1" /standard_name="D17S1473E" /db_xref="UniSTS:151680" STS 4189..4813 /standard_name="PMC55343P1" /db_xref="UniSTS:273322" gene 4263..4331 /gene="TRNI" /gene_synonym="MTTI" /nomenclature="Official Symbol: MT-TI | Name: mitochondrially encoded tRNA isoleucine | Provided by: HGNC:HGNC:7488" /db_xref="GeneID:4565" /db_xref="HGNC:HGNC:7488" /db_xref="MIM:590045" tRNA 4263..4331 /gene="TRNI" /gene_synonym="MTTI" /product="tRNA-Ile" /note="NAR: 0997" /anticodon=(pos:4292..4294,aa:Ile,seq:gat) /codon_recognized="AUC" /db_xref="GeneID:4565" /db_xref="HGNC:HGNC:7488" /db_xref="MIM:590045" gene complement(4329..4400) /gene="TRNQ" /gene_synonym="MTTQ" /nomenclature="Official Symbol: MT-TQ | Name: mitochondrially encoded tRNA glutamine | Provided by: HGNC:HGNC:7495" /db_xref="GeneID:4572" /db_xref="HGNC:HGNC:7495" /db_xref="MIM:590030" tRNA complement(4329..4400) /gene="TRNQ" /gene_synonym="MTTQ" /product="tRNA-Gln" /note="NAR: 0597" /anticodon=(pos:complement(4365..4367),aa:Gln,seq:ttg) /codon_recognized="CAA" /db_xref="GeneID:4572" /db_xref="HGNC:HGNC:7495" /db_xref="MIM:590030" gene 4402..4469 /gene="TRNM" /gene_synonym="MTTM" /nomenclature="Official Symbol: MT-TM | Name: mitochondrially encoded tRNA methionine | Provided by: HGNC:HGNC:7492" /db_xref="GeneID:4569" /db_xref="HGNC:HGNC:7492" /db_xref="MIM:590065" tRNA 4402..4469 /gene="TRNM" /gene_synonym="MTTM" /product="tRNA-Met" /note="NAR: 1297" /anticodon=(pos:4432..4434,aa:Met,seq:cat) /codon_recognized="AUG" /db_xref="GeneID:4569" /db_xref="HGNC:HGNC:7492" /db_xref="MIM:590065" gene 4470..5511 /gene="ND2" /gene_synonym="MTND2" /nomenclature="Official Symbol: MT-ND2 | Name: mitochondrially encoded NADH dehydrogenase 2 | Provided by: HGNC:HGNC:7456" /db_xref="GeneID:4536" /db_xref="HGNC:HGNC:7456" /db_xref="MIM:516001" CDS 4470..5511 /gene="ND2" /gene_synonym="MTND2" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:5511,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 2" /protein_id="YP_003024027.1" /db_xref="GI:251831108" /db_xref="GeneID:4536" /db_xref="HGNC:HGNC:7456" /db_xref="MIM:516001" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" STS 4481..5456 /gene="ND2" /gene_synonym="MTND2" /standard_name="PMC113853P1" /db_xref="UniSTS:270258" gene 5512..5579 /gene="TRNW" /gene_synonym="MTTW" /nomenclature="Official Symbol: MT-TW | Name: mitochondrially encoded tRNA tryptophan | Provided by: HGNC:HGNC:7501" /db_xref="GeneID:4578" /db_xref="HGNC:HGNC:7501" /db_xref="MIM:590095" tRNA 5512..5579 /gene="TRNW" /gene_synonym="MTTW" /product="tRNA-Trp" /note="NAR: 1897" /anticodon=(pos:5544..5546,aa:Trp,seq:tca) /codon_recognized="UGA" /db_xref="GeneID:4578" /db_xref="HGNC:HGNC:7501" /db_xref="MIM:590095" gene complement(5587..5655) /gene="TRNA" /gene_synonym="MTTA" /nomenclature="Official Symbol: MT-TA | Name: mitochondrially encoded tRNA alanine | Provided by: HGNC:HGNC:7475" /db_xref="GeneID:4553" /db_xref="HGNC:HGNC:7475" /db_xref="MIM:590000" tRNA complement(5587..5655) /gene="TRNA" /gene_synonym="MTTA" /product="tRNA-Ala" /note="NAR: 0097" /anticodon=(pos:complement(5623..5625),aa:Ala,seq:tgc) /codon_recognized="GCA" /db_xref="GeneID:4553" /db_xref="HGNC:HGNC:7475" /db_xref="MIM:590000" gene complement(5657..5729) /gene="TRNN" /gene_synonym="MTTN" /nomenclature="Official Symbol: MT-TN | Name: mitochondrially encoded tRNA asparagine | Provided by: HGNC:HGNC:7493" /db_xref="GeneID:4570" /db_xref="HGNC:HGNC:7493" /db_xref="MIM:590010" tRNA complement(5657..5729) /gene="TRNN" /gene_synonym="MTTN" /product="tRNA-Asn" /note="NAR: 0297" /anticodon=(pos:complement(5694..5696),aa:Asn,seq:gtt) /codon_recognized="AAC" /db_xref="GeneID:4570" /db_xref="HGNC:HGNC:7493" /db_xref="MIM:590010" gene complement(5761..5826) /gene="TRNC" /gene_synonym="MTTC" /nomenclature="Official Symbol: MT-TC | Name: mitochondrially encoded tRNA cysteine | Provided by: HGNC:HGNC:7477" /db_xref="GeneID:4511" /db_xref="HGNC:HGNC:7477" /db_xref="MIM:590020" tRNA complement(5761..5826) /gene="TRNC" /gene_synonym="MTTC" /product="tRNA-Cys" /note="NAR: 0497" /anticodon=(pos:complement(5796..5798),aa:Cys,seq:gca) /codon_recognized="UGC" /db_xref="GeneID:4511" /db_xref="HGNC:HGNC:7477" /db_xref="MIM:590020" gene complement(5826..5891) /gene="TRNY" /gene_synonym="MTTY" /nomenclature="Official Symbol: MT-TY | Name: mitochondrially encoded tRNA tyrosine | Provided by: HGNC:HGNC:7502" /db_xref="GeneID:4579" /db_xref="HGNC:HGNC:7502" /db_xref="MIM:590100" tRNA complement(5826..5891) /gene="TRNY" /gene_synonym="MTTY" /product="tRNA-Tyr" /note="NAR: 1997" /anticodon=(pos:complement(5860..5862),aa:Tyr,seq:gta) /codon_recognized="UAC" /db_xref="GeneID:4579" /db_xref="HGNC:HGNC:7502" /db_xref="MIM:590100" gene 5904..7445 /gene="COX1" /gene_synonym="COI; MTCO1" /nomenclature="Official Symbol: MT-CO1 | Name: mitochondrially encoded cytochrome c oxidase I | Provided by: HGNC:HGNC:7419" /db_xref="GeneID:4512" /db_xref="HGNC:HGNC:7419" /db_xref="MIM:516030" CDS 5904..7445 /gene="COX1" /gene_synonym="COI; MTCO1" /note="cytochrome c oxidase I" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit I" /protein_id="YP_003024028.1" /db_xref="GI:251831109" /db_xref="GeneID:4512" /db_xref="HGNC:HGNC:7419" /db_xref="MIM:516030" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" STS 6318..6918 /gene="COX1" /gene_synonym="COI; MTCO1" /standard_name="PMC55343P2" /db_xref="UniSTS:273325" STS 7125..7672 /standard_name="PMC20756P3" /db_xref="UniSTS:271963" STS 7166..7361 /gene="COX1" /gene_synonym="COI; MTCO1" /standard_name="D17S813E" /db_xref="UniSTS:92461" STS 7358..7937 /standard_name="PMC55343P3" /db_xref="UniSTS:273326" STS 7386..7513 /standard_name="RH98513" /db_xref="UniSTS:83580" gene complement(7446..7514) /gene="TRNS1" /gene_synonym="MTTS1" /nomenclature="Official Symbol: MT-TS1 | Name: mitochondrially encoded tRNA serine 1 (UCN)" /db_xref="GeneID:4574" /db_xref="HGNC:HGNC:7497" /db_xref="MIM:590080" tRNA complement(7446..7514) /gene="TRNS1" /gene_synonym="MTTS1" /product="tRNA-Ser" /note="NAR: 1697" /anticodon=(pos:complement(7482..7484),aa:Ser,seq:tga) /codon_recognized="UCN" /db_xref="GeneID:4574" /db_xref="HGNC:HGNC:7497" /db_xref="MIM:590080" STS 7483..8383 /standard_name="PMC20756P2" /db_xref="UniSTS:271962" STS 7483..8364 /standard_name="PMC109173P1" /db_xref="UniSTS:270154" STS 7483..7570 /standard_name="PMC20756P1" /db_xref="UniSTS:271961" gene 7518..7585 /gene="TRND" /gene_synonym="MTTD" /nomenclature="Official Symbol: MT-TD | Name: mitochondrially encoded tRNA aspartic acid | Provided by: HGNC:HGNC:7478" /db_xref="GeneID:4555" /db_xref="HGNC:HGNC:7478" /db_xref="MIM:590015" tRNA 7518..7585 /gene="TRND" /gene_synonym="MTTD" /product="tRNA-Asp" /note="NAR: 0397" /anticodon=(pos:7548..7550,aa:Asp,seq:gtc) /codon_recognized="GAC" /db_xref="GeneID:4555" /db_xref="HGNC:HGNC:7478" /db_xref="MIM:590015" STS 7561..7983 /standard_name="PMC196577P3" /db_xref="UniSTS:271816" gene 7586..8269 /gene="COX2" /gene_synonym="COII; MTCO2" /nomenclature="Official Symbol: MT-CO2 | Name: mitochondrially encoded cytochrome c oxidase II | Provided by: HGNC:HGNC:7421" /db_xref="GeneID:4513" /db_xref="HGNC:HGNC:7421" /db_xref="MIM:516040" CDS 7586..8269 /gene="COX2" /gene_synonym="COII; MTCO2" /note="cytochrome c oxidase II" /codon_start=1 /transl_table=2 /product="cytochrome c oxidase subunit II" /protein_id="YP_003024029.1" /db_xref="GI:251831110" /db_xref="GeneID:4513" /db_xref="HGNC:HGNC:7421" /db_xref="MIM:516040" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" STS 7690..7773 /gene="COX2" /gene_synonym="COII; MTCO2" /standard_name="D1S2077E" /db_xref="UniSTS:151716" STS 8164..8291 /standard_name="SHGC-57364" /db_xref="UniSTS:67674" STS 8280..8882 /standard_name="PMC55343P5" /db_xref="UniSTS:273328" STS 8280..8366 /standard_name="PMC55343P4" /db_xref="UniSTS:273327" gene 8295..8364 /gene="TRNK" /gene_synonym="MTTK" /nomenclature="Official Symbol: MT-TK | Name: mitochondrially encoded tRNA lysine | Provided by: HGNC:HGNC:7489" /db_xref="GeneID:4566" /db_xref="HGNC:HGNC:7489" /db_xref="MIM:590060" tRNA 8295..8364 /gene="TRNK" /gene_synonym="MTTK" /product="tRNA-Lys" /note="NAR: 1197" /anticodon=(pos:8323..8325,aa:Lys,seq:ttt) /codon_recognized="AAA" /db_xref="GeneID:4566" /db_xref="HGNC:HGNC:7489" /db_xref="MIM:590060" gene 8366..8572 /gene="ATP8" /gene_synonym="ATPase8; MTATP8" /nomenclature="Official Symbol: MT-ATP8 | Name: mitochondrially encoded ATP synthase 8 | Provided by: HGNC:HGNC:7415" /db_xref="GeneID:4509" /db_xref="HGNC:HGNC:7415" /db_xref="MIM:516070" CDS 8366..8572 /gene="ATP8" /gene_synonym="ATPase8; MTATP8" /note="ATP synthase 8; ATPase subunit 8" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 8" /protein_id="YP_003024030.1" /db_xref="GI:251831111" /db_xref="GeneID:4509" /db_xref="HGNC:HGNC:7415" /db_xref="MIM:516070" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" gene 8527..9207 /gene="ATP6" /gene_synonym="ATPase6; MTATP6" /nomenclature="Official Symbol: MT-ATP6 | Name: mitochondrially encoded ATP synthase 6 | Provided by: HGNC:HGNC:7414" /db_xref="GeneID:4508" /db_xref="HGNC:HGNC:7414" /db_xref="MIM:516060" CDS 8527..9207 /gene="ATP6" /gene_synonym="ATPase6; MTATP6" /note="ATP synthase 6; ATPase subunit 6" /codon_start=1 /transl_table=2 /product="ATP synthase F0 subunit 6" /protein_id="YP_003024031.1" /db_xref="GI:251831112" /db_xref="GeneID:4508" /db_xref="HGNC:HGNC:7414" /db_xref="MIM:516060" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" STS 8779..9416 /standard_name="PMC55343P7" /db_xref="UniSTS:273330" STS 8779..8882 /gene="ATP6" /gene_synonym="ATPase6; MTATP6" /standard_name="PMC55343P6" /db_xref="UniSTS:273329" gene 9207..9990 /gene="COX3" /gene_synonym="COIII; MTCO3" /nomenclature="Official Symbol: MT-CO3 | Name: mitochondrially encoded cytochrome c oxidase III | Provided by: HGNC:HGNC:7422" /db_xref="GeneID:4514" /db_xref="HGNC:HGNC:7422" /db_xref="MIM:516050" CDS 9207..9990 /gene="COX3" /gene_synonym="COIII; MTCO3" /note="cytochrome c oxidase III; TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9990,aa:TERM) /transl_table=2 /product="cytochrome c oxidase subunit III" /protein_id="YP_003024032.1" /db_xref="GI:251831113" /db_xref="GeneID:4514" /db_xref="HGNC:HGNC:7422" /db_xref="MIM:516050" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS" STS 9342..9416 /gene="COX3" /gene_synonym="COIII; MTCO3" /standard_name="PMC55343P8" /db_xref="UniSTS:273331" gene 9991..10058 /gene="TRNG" /gene_synonym="MTTG" /nomenclature="Official Symbol: MT-TG | Name: mitochondrially encoded tRNA glycine | Provided by: HGNC:HGNC:7486" /db_xref="GeneID:4563" /db_xref="HGNC:HGNC:7486" /db_xref="MIM:590035" tRNA 9991..10058 /gene="TRNG" /gene_synonym="MTTG" /product="tRNA-Gly" /note="NAR: 0797" /anticodon=(pos:10021..10023,aa:Gly,seq:tcc) /codon_recognized="GGA" /db_xref="GeneID:4563" /db_xref="HGNC:HGNC:7486" /db_xref="MIM:590035" gene 10059..10404 /gene="ND3" /gene_synonym="MTND3" /nomenclature="Official Symbol: MT-ND3 | Name: mitochondrially encoded NADH dehydrogenase 3 | Provided by: HGNC:HGNC:7458" /db_xref="GeneID:4537" /db_xref="HGNC:HGNC:7458" /db_xref="MIM:516002" CDS 10059..10404 /gene="ND3" /gene_synonym="MTND3" /note="NADH dehydrogenase, subunit 3 (complex I); TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:10404,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 3" /protein_id="YP_003024033.1" /db_xref="GI:251831114" /db_xref="GeneID:4537" /db_xref="HGNC:HGNC:7458" /db_xref="MIM:516002" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" gene 10405..10469 /gene="TRNR" /gene_synonym="MTTR" /nomenclature="Official Symbol: MT-TR | Name: mitochondrially encoded tRNA arginine | Provided by: HGNC:HGNC:7496" /db_xref="GeneID:4573" /db_xref="HGNC:HGNC:7496" /db_xref="MIM:590005" tRNA 10405..10469 /gene="TRNR" /gene_synonym="MTTR" /product="tRNA-Arg" /note="NAR: 0197" /anticodon=(pos:10435..10437,aa:Arg,seq:tcg) /codon_recognized="CGA" /db_xref="GeneID:4573" /db_xref="HGNC:HGNC:7496" /db_xref="MIM:590005" gene 10470..10766 /gene="ND4L" /gene_synonym="MTND4L" /nomenclature="Official Symbol: MT-ND4L | Name: mitochondrially encoded NADH 4L dehydrogenase | Provided by: HGNC:HGNC:7460" /db_xref="GeneID:4539" /db_xref="HGNC:HGNC:7460" /db_xref="MIM:516004" CDS 10470..10766 /gene="ND4L" /gene_synonym="MTND4L" /note="NADH dehydrogenase, subunit 4L (complex I)" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 4L" /protein_id="YP_003024034.1" /db_xref="GI:251831115" /db_xref="GeneID:4539" /db_xref="HGNC:HGNC:7460" /db_xref="MIM:516004" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" gene 10760..12137 /gene="ND4" /gene_synonym="MTND4" /nomenclature="Official Symbol: MT-ND4 | Name: mitochondrially encoded NADH dehydrogenase 4 | Provided by: HGNC:HGNC:7459" /db_xref="GeneID:4538" /db_xref="HGNC:HGNC:7459" /db_xref="MIM:516003" CDS 10760..12137 /gene="ND4" /gene_synonym="MTND4" /note="NADH dehydrogenase, subunit 4 (complex I); TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:12137,aa:TERM) /transl_table=2 /product="NADH dehydrogenase subunit 4" /protein_id="YP_003024035.1" /db_xref="GI:251831116" /db_xref="GeneID:4538" /db_xref="HGNC:HGNC:7459" /db_xref="MIM:516003" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" gene 12138..12206 /gene="TRNH" /gene_synonym="MTTH" /nomenclature="Official Symbol: MT-TH | Name: mitochondrially encoded tRNA histidine | Provided by: HGNC:HGNC:7487" /db_xref="GeneID:4564" /db_xref="HGNC:HGNC:7487" /db_xref="MIM:590040" tRNA 12138..12206 /gene="TRNH" /gene_synonym="MTTH" /product="tRNA-His" /note="NAR: 0897" /anticodon=(pos:12168..12170,aa:His,seq:gtg) /codon_recognized="CAC" /db_xref="GeneID:4564" /db_xref="HGNC:HGNC:7487" /db_xref="MIM:590040" gene 12207..12265 /gene="TRNS2" /gene_synonym="MTTS2" /nomenclature="Official Symbol: MT-TS2 | Name: mitochondrially encoded tRNA serine 2 (AGU/C) | Provided by: HGNC:HGNC:7498" /db_xref="GeneID:4575" /db_xref="HGNC:HGNC:7498" /db_xref="MIM:590085" tRNA 12207..12265 /gene="TRNS2" /gene_synonym="MTTS2" /product="tRNA-Ser" /note="NAR: 1656" /anticodon=(pos:12226..12228,aa:Ser,seq:gct) /codon_recognized="AGY" /db_xref="GeneID:4575" /db_xref="HGNC:HGNC:7498" /db_xref="MIM:590085" gene 12266..12336 /gene="TRNL2" /gene_synonym="MTTL2" /nomenclature="Official Symbol: MT-TL2 | Name: mitochondrially encoded tRNA leucine 2 (CUN) | Provided by: HGNC:HGNC:7491" /db_xref="GeneID:4568" /db_xref="HGNC:HGNC:7491" /db_xref="MIM:590055" tRNA 12266..12336 /gene="TRNL2" /gene_synonym="MTTL2" /product="tRNA-Leu" /note="NAR: 1097" /anticodon=(pos:12298..12300,aa:Leu,seq:tag) /codon_recognized="CUN" /db_xref="GeneID:4568" /db_xref="HGNC:HGNC:7491" /db_xref="MIM:590055" gene 12337..14148 /gene="ND5" /gene_synonym="MTND5" /nomenclature="Official Symbol: MT-ND5 | Name: mitochondrially encoded NADH dehydrogenase 5 | Provided by: HGNC:HGNC:7461" /db_xref="GeneID:4540" /db_xref="HGNC:HGNC:7461" /db_xref="MIM:516005" CDS 12337..14148 /gene="ND5" /gene_synonym="MTND5" /note="NADH dehydrogenase, subunit 5 (complex I)" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 5" /protein_id="YP_003024036.1" /db_xref="GI:251831117" /db_xref="GeneID:4540" /db_xref="HGNC:HGNC:7461" /db_xref="MIM:516005" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" STS 13068..13143 /gene="ND5" /gene_synonym="MTND5" /standard_name="PMC55343P9" /db_xref="UniSTS:273332" STS 13593..14206 /standard_name="PMC55343P10" /db_xref="UniSTS:273323" STS 14104..14206 /standard_name="PMC55343P12" /db_xref="UniSTS:273324" gene complement(14149..14673) /gene="ND6" /gene_synonym="MTND6" /nomenclature="Official Symbol: MT-ND6 | Name: mitochondrially encoded NADH dehydrogenase 6 | Provided by: HGNC:HGNC:7462" /db_xref="GeneID:4541" /db_xref="HGNC:HGNC:7462" /db_xref="MIM:516006" CDS complement(14149..14673) /gene="ND6" /gene_synonym="MTND6" /note="NADH dehydrogenase, subunit 6 (complex I)" /codon_start=1 /transl_table=2 /product="NADH dehydrogenase subunit 6" /protein_id="YP_003024037.1" /db_xref="GI:251831118" /db_xref="GeneID:4541" /db_xref="HGNC:HGNC:7462" /db_xref="MIM:516006" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" gene complement(14674..14742) /gene="TRNE" /gene_synonym="MTTE" /nomenclature="Official Symbol: MT-TE | Name: mitochondrially encoded tRNA glutamic acid | Provided by: HGNC:HGNC:7479" /db_xref="GeneID:4556" /db_xref="HGNC:HGNC:7479" /db_xref="MIM:590025" tRNA complement(14674..14742) /gene="TRNE" /gene_synonym="MTTE" /product="tRNA-Glu" /note="NAR: 0697" /anticodon=(pos:complement(14710..14712),aa:Glu,seq:ttc) /codon_recognized="GAA" /db_xref="GeneID:4556" /db_xref="HGNC:HGNC:7479" /db_xref="MIM:590025" gene 14747..15887 /gene="CYTB" /gene_synonym="MTCYB" /nomenclature="Official Symbol: MT-CYB | Name: mitochondrially encoded cytochrome b | Provided by: HGNC:HGNC:7427" /db_xref="GeneID:4519" /db_xref="HGNC:HGNC:7427" /db_xref="MIM:516020" CDS 14747..15887 /gene="CYTB" /gene_synonym="MTCYB" /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15887,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="YP_003024038.1" /db_xref="GI:251831119" /db_xref="GeneID:4519" /db_xref="HGNC:HGNC:7427" /db_xref="MIM:516020" /translation="MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLKWA" STS 15191..15307 /gene="CYTB" /gene_synonym="MTCYB" /standard_name="GDB:451664" /db_xref="UniSTS:157340" STS 15698..15777 /gene="CYTB" /gene_synonym="MTCYB" /standard_name="D1S2076E" /db_xref="UniSTS:151706" gene 15888..15953 /gene="TRNT" /gene_synonym="MTTT" /nomenclature="Official Symbol: MT-TT | Name: mitochondrially encoded tRNA threonine | Provided by: HGNC:HGNC:7499" /db_xref="GeneID:4576" /db_xref="HGNC:HGNC:7499" /db_xref="MIM:590090" tRNA 15888..15953 /gene="TRNT" /gene_synonym="MTTT" /product="tRNA-Thr" /note="NAR: 1797" /anticodon=(pos:15919..15921,aa:Thr,seq:tgt) /codon_recognized="ACA" /db_xref="GeneID:4576" /db_xref="HGNC:HGNC:7499" /db_xref="MIM:590090" gene complement(15956..16023) /gene="TRNP" /gene_synonym="MTTP" /nomenclature="Official Symbol: MT-TP | Name: mitochondrially encoded tRNA proline | Provided by: HGNC:HGNC:7494" /db_xref="GeneID:4571" /db_xref="HGNC:HGNC:7494" /db_xref="MIM:590075" tRNA complement(15956..16023) /gene="TRNP" /gene_synonym="MTTP" /product="tRNA-Pro" /note="NAR: 1597" /anticodon=(pos:complement(15990..15992),aa:Pro,seq:tgg) /codon_recognized="CCA" /db_xref="GeneID:4571" /db_xref="HGNC:HGNC:7494" /db_xref="MIM:590075" ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtatgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccactttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct cccccgcttc tggccacagc acttaaacac atctctgcca aaccccaaaa 361 acaaagaacc ctaacaccag cctaaccaga tttcaaattt tatcttttgg cggtatgcac 421 ttttaacagt caccccccaa ctaacacatt attttcccct cccactccca tactactaat 481 ctcatcaata caacccccgc ccatcctacc cagcacacac acaccgctgc taaccccata 541 ccccgaacca accaaacccc aaagacaccc cccacagttt atgtagctta cctcctcaaa 601 gcaatacact gaaaatgttt agacgggctc acatcacccc ataaacaaat aggtttggtc 661 ctagcctttc tattagctct tagtaagatt acacatgcaa gcatccccgt tccagtgagt 721 tcaccctcta aatcaccacg atcaaaagga acaagcatca agcacgcagc aatgcagctc 781 aaaacgctta gcctagccac acccccacgg gaaacagcag tgattaacct ttagcaataa 841 acgaaagttt aactaagcta tactaacccc agggttggtc aatttcgtgc cagccaccgc 901 ggtcacacga ttaacccaag tcaatagaag ccggcgtaaa gagtgtttta gatcaccccc 961 tccccaataa agctaaaact cacctgagtt gtaaaaaact ccagttgaca caaaatagac 1021 tacgaaagtg gctttaacat atctgaacac acaatagcta agacccaaac tgggattaga 1081 taccccacta tgcttagccc taaacctcaa cagttaaatc aacaaaactg ctcgccagaa 1141 cactacgagc cacagcttaa aactcaaagg acctggcggt gcttcatatc cctctagagg 1201 agcctgttct gtaatcgata aaccccgatc aacctcacca cctcttgctc agcctatata 1261 ccgccatctt cagcaaaccc tgatgaaggc tacaaagtaa gcgcaagtac ccacgtaaag 1321 acgttaggtc aaggtgtagc ccatgaggtg gcaagaaatg ggctacattt tctaccccag 1381 aaaactacga tagcccttat gaaacttaag ggtcgaaggt ggatttagca gtaaactaag 1441 agtagagtgc ttagttgaac agggccctga agcgcgtaca caccgcccgt caccctcctc 1501 aagtatactt caaaggacat ttaactaaaa cccctacgca tttatataga ggagacaagt 1561 cgtaacatgg taagtgtact ggaaagtgca cttggacgaa ccagagtgta gcttaacaca 1621 aagcacccaa cttacactta ggagatttca acttaacttg accgctctga gctaaaccta 1681 gccccaaacc cactccacct tactaccaga caaccttagc caaaccattt acccaaataa 1741 agtataggcg atagaaattg aaacctggcg caatagatat agtaccgcaa gggaaagatg 1801 aaaaattata accaagcata atatagcaag gactaacccc tataccttct gcataatgaa 1861 ttaactagaa ataactttgc aaggagagcc aaagctaaga cccccgaaac cagacgagct 1921 acctaagaac agctaaaaga gcacacccgt ctatgtagca aaatagtggg aagatttata 1981 ggtagaggcg acaaacctac cgagcctggt gatagctggt tgtccaagat agaatcttag 2041 ttcaacttta aatttgccca cagaaccctc taaatcccct tgtaaattta actgttagtc 2101 caaagaggaa cagctctttg gacactagga aaaaaccttg tagagagagt aaaaaattta 2161 acacccatag taggcctaaa agcagccacc aattaagaaa gcgttcaagc tcaacaccca 2221 ctacctaaaa aatcccaaac atataactga actcctcaca cccaattgga ccaatctatc 2281 accctataga agaactaatg ttagtataag taacatgaaa acattctcct ccgcataagc 2341 ctgcgtcaga ttaaaacact gaactgacaa ttaacagccc aatatctaca atcaaccaac 2401 aagtcattat taccctcact gtcaacccaa cacaggcatg ctcataagga aaggttaaaa 2461 aaagtaaaag gaactcggca aatcttaccc cgcctgttta ccaaaaacat cacctctagc 2521 atcaccagta ttagaggcac cgcctgccca gtgacacatg tttaacggcc gcggtaccct 2581 aaccgtgcaa aggtagcata atcacttgtt ccttaaatag ggacctgtat gaatggctcc 2641 acgagggttc agctgtctct tacttttaac cagtgaaatt gacctgcccg tgaagaggcg 2701 ggcataacac agcaagacga gaagacccta tggagcttta atttattaat gcaaacagta 2761 cctaacaaac ccacaggtcc taaactacca aacctgcatt aaaaatttcg gttggggcga 2821 cctcggagca gaacccaacc tccgagcagt acatgctaag acttcaccag tcaaagcgaa 2881 ctactatact caattgatcc aataacttga ccaacggaac aagttaccct agggataaca 2941 gcgcaatcct attctagagt ccatatcaac aatagggttt acgacctcga tgttggatca 3001 ggacatcccg atggtgcagc cgctattaaa ggttcgtttg ttcaacgatt aaagtcctac 3061 gtgatctgag ttcagaccgg agtaatccag gtcggtttct atctacnttc aaattcctcc 3121 ctgtacgaaa ggacaagaga aataaggcct acttcacaaa gcgccttccc ccgtaaatga 3181 tatcatctca acttagtatt atacccacac ccacccaaga acagggtttg ttaagatggc 3241 agagcccggt aatcgcataa aacttaaaac tttacagtca gaggttcaat tcctcttctt 3301 aacaacatac ccatggccaa cctcctactc ctcattgtac ccattctaat cgcaatggca 3361 ttcctaatgc ttaccgaacg aaaaattcta ggctatatac aactacgcaa aggccccaac 3421 gttgtaggcc cctacgggct actacaaccc ttcgctgacg ccataaaact cttcaccaaa 3481 gagcccctaa aacccgccac atctaccatc accctctaca tcaccgcccc gaccttagct 3541 ctcaccatcg ctcttctact atgaaccccc ctccccatac ccaaccccct ggtcaacctc 3601 aacctaggcc tcctatttat tctagccacc tctagcctag ccgtttactc aatcctctga 3661 tcagggtgag catcaaactc aaactacgcc ctgatcggcg cactgcgagc agtagcccaa 3721 acaatctcat atgaagtcac cctagccatc attctactat caacattact aataagtggc 3781 tcctttaacc tctccaccct tatcacaaca caagaacacc tctgattact cctgccatca 3841 tgacccttgg ccataatatg atttatctcc acactagcag agaccaaccg aacccccttc 3901 gaccttgccg aaggggagtc cgaactagtc tcaggcttca acatcgaata cgccgcaggc 3961 cccttcgccc tattcttcat agccgaatac acaaacatta ttataataaa caccctcacc 4021 actacaatct tcctaggaac aacatatgac gcactctccc ctgaactcta cacaacatat 4081 tttgtcacca agaccctact tctaacctcc ctgttcttat gaattcgaac agcatacccc 4141 cgattccgct acgaccaact catacacctc ctatgaaaaa acttcctacc actcacccta 4201 gcattactta tatgatatgt ctccataccc attacaatct ccagcattcc ccctcaaacc 4261 taagaaatat gtctgataaa agagttactt tgatagagta aataatagga gcttaaaccc 4321 ccttatttct aggactatga gaatcgaacc catccctgag aatccaaaat tctccgtgcc 4381 acctatcaca ccccatccta aagtaaggtc agctaaataa gctatcgggc ccataccccg 4441 aaaatgttgg ttataccctt cccgtactaa ttaatcccct ggcccaaccc gtcatctact 4501 ctaccatctt tgcaggcaca ctcatcacag cgctaagctc gcactgattt tttacctgag 4561 taggcctaga aataaacatg ctagctttta ttccagttct aaccaaaaaa ataaaccctc 4621 gttccacaga agctgccatc aagtatttcc tcacgcaagc aaccgcatcc ataatccttc 4681 taatagctat cctcttcaac aatatactct ccggacaatg aaccataacc aatactacca 4741 atcaatactc atcattaata atcataatag ctatagcaat aaaactagga atagccccct 4801 ttcacttctg agtcccagag gttacccaag gcacccctct gacatccggc ctgcttcttc 4861 tcacatgaca aaaactagcc cccatctcaa tcatatacca aatctctccc tcactaaacg 4921 taagccttct cctcactctc tcaatcttat ccatcatagc aggcagttga ggtggattaa 4981 accaaaccca gctacgcaaa atcttagcat actcctcaat tacccacata ggatgaataa 5041 tagcagttct accgtacaac cctaacataa ccattcttaa tttaactatt tatattatcc 5101 taactactac cgcattccta ctactcaact taaactccag caccacgacc ctactactat 5161 ctcgcacctg aaacaagcta acatgactaa cacccttaat tccatccacc ctcctctccc 5221 taggaggcct gcccccgcta accggctttt tgcccaaatg ggccattatc gaagaattca 5281 caaaaaacaa tagcctcatc atccccacca tcatagccac catcaccctc cttaacctct 5341 acttctacct acgcctaatc tactccacct caatcacact actccccata tctaacaacg 5401 taaaaataaa atgacagttt gaacatacaa aacccacccc attcctcccc acactcatcg 5461 cccttaccac gctactccta cctatctccc cttttatact aataatctta tagaaattta 5521 ggttaaatac agaccaagag ccttcaaagc cctcagtaag ttgcaatact taatttctgt 5581 aacagctaag gactgcaaaa ccccactctg catcaactga acgcaaatca gccactttaa 5641 ttaagctaag cccttactag accaatggga cttaaaccca caaacactta gttaacagct 5701 aagcacccta atcaactggc ttcaatctac ttctcccgcc gccgggaaaa aaggcgggag 5761 aagccccggc aggtttgaag ctgcttcttc gaatttgcaa ttcaatatga aaatcacctc 5821 ggagctggta aaaagaggcc taacccctgt ctttagattt acagtccaat gcttcactca 5881 gccattttac ctcaccccca ctgatgttcg ccgaccgttg actattctct acaaaccaca 5941 aagacattgg aacactatac ctattattcg gcgcatgagc tggagtccta ggcacagctc 6001 taagcctcct tattcgagcc gagctgggcc agccaggcaa ccttctaggt aacgaccaca 6061 tctacaacgt tatcgtcaca gcccatgcat ttgtaataat cttcttcata gtaataccca 6121 tcataatcgg aggctttggc aactgactag ttcccctaat aatcggtgcc cccgatatgg 6181 cgtttccccg cataaacaac ataagcttct gactcttacc tccctctctc ctactcctgc 6241 tcgcatctgc tatagtggag gccggagcag gaacaggttg aacagtctac cctcccttag 6301 cagggaacta ctcccaccct ggagcctccg tagacctaac catcttctcc ttacacctag 6361 caggtgtctc ctctatctta ggggccatca atttcatcac aacaattatc aatataaaac 6421 cccctgccat aacccaatac caaacgcccc tcttcgtctg atccgtccta atcacagcag 6481 tcctacttct cctatctctc ccagtcctag ctgctggcat cactatacta ctaacagacc 6541 gcaacctcaa caccaccttc ttcgaccccg ccggaggagg agaccccatt ctataccaac 6601 acctattctg atttttcggt caccctgaag tttatattct tatcctacca ggcttcggaa 6661 taatctccca tattgtaact tactactccg gaaaaaaaga accatttgga tacataggta 6721 tggtctgagc tatgatatca attggcttcc tagggtttat cgtgtgagca caccatatat 6781 ttacagtagg aatagacgta gacacacgag catatttcac ctccgctacc ataatcatcg 6841 ctatccccac cggcgtcaaa gtatttagct gactcgccac actccacgga agcaatatga 6901 aatgatctgc tgcagtgctc tgagccctag gattcatctt tcttttcacc gtaggtggcc 6961 tgactggcat tgtattagca aactcatcac tagacatcgt actacacgac acgtactacg 7021 ttgtagccca cttccactat gtcctatcaa taggagctgt atttgccatc ataggaggct 7081 tcattcactg atttccccta ttctcaggct acaccctaga ccaaacctac gccaaaatcc 7141 atttcactat catattcatc ggcgtaaatc taactttctt cccacaacac tttctcggcc 7201 tatccggaat gccccgacgt tactcggact accccgatgc atacaccaca tgaaacatcc 7261 tatcatctgt aggctcattc atttctctaa cagcagtaat attaataatt ttcatgattt 7321 gagaagcctt cgcttcgaag cgaaaagtcc taatagtaga agaaccctcc ataaacctgg 7381 agtgactata tggatgcccc ccaccctacc acacattcga agaacccgta tacataaaat 7441 ctagacaaaa aaggaaggaa tcgaaccccc caaagctggt ttcaagccaa ccccatggcc 7501 tccatgactt tttcaaaaag gtattagaaa aaccatttca taactttgtc aaagttaaat 7561 tataggctaa atcctatata tcttaatggc acatgcagcg caagtaggtc tacaagacgc 7621 tacttcccct atcatagaag agcttatcac ctttcatgat cacgccctca taatcatttt 7681 ccttatctgc ttcctagtcc tgtatgccct tttcctaaca ctcacaacaa aactaactaa 7741 tactaacatc tcagacgctc aggaaataga aaccgtctga actatcctgc ccgccatcat 7801 cctagtcctc atcgccctcc catccctacg catcctttac ataacagacg aggtcaacga 7861 tccctccctt accatcaaat caattggcca ccaatggtac tgaacctacg agtacaccga 7921 ctacggcgga ctaatcttca actcctacat acttccccca ttattcctag aaccaggcga 7981 cctgcgactc cttgacgttg acaatcgagt agtactcccg attgaagccc ccattcgtat 8041 aataattaca tcacaagacg tcttgcactc atgagctgtc cccacattag gcttaaaaac 8101 agatgcaatt cccggacgtc taaaccaaac cactttcacc gctacacgac cgggggtata 8161 ctacggtcaa tgctctgaaa tctgtggagc aaaccacagt ttcatgccca tcgtcctaga 8221 attaattccc ctaaaaatct ttgaaatagg gcccgtattt accctatagc accccctcta 8281 ccccctctag agcccactgt aaagctaact tagcattaac cttttaagtt aaagattaag 8341 agaaccaaca cctctttaca gtgaaatgcc ccaactaaat actaccgtat ggcccaccat 8401 aattaccccc atactcctta cactattcct catcacccaa ctaaaaatat taaacacaaa 8461 ctaccaccta cctccctcac caaagcccat aaaaataaaa aattataaca aaccctgaga 8521 accaaaatga acgaaaatct gttcgcttca ttcattgccc ccacaatcct aggcctaccc 8581 gccgcagtac tgatcattct atttccccct ctattgatcc ccacctccaa atatctcatc 8641 aacaaccgac taatcaccac ccaacaatga ctaatcaaac taacctcaaa acaaatgata 8701 accatacaca acactaaagg acgaacctga tctcttatac tagtatcctt aatcattttt 8761 attgccacaa ctaacctcct cggactcctg cctcactcat ttacaccaac cacccaacta 8821 tctataaacc tagccatggc catcccctta tgagcgggca cagtgattat aggctttcgc 8881 tctaagatta aaaatgccct agcccacttc ttaccacaag gcacacctac accccttatc 8941 cccatactag ttattatcga aaccatcagc ctactcattc aaccaatagc cctggccgta 9001 cgcctaaccg ctaacattac tgcaggccac ctactcatgc acctaattgg aagcgccacc 9061 ctagcaatat caaccattaa ccttccctct acacttatca tcttcacaat tctaattcta 9121 ctgactatcc tagaaatcgc tgtcgcctta atccaagcct acgttttcac acttctagta 9181 agcctctacc tgcacgacaa cacataatga cccaccaatc acatgcctat catatagtaa 9241 aacccagccc atgaccccta acaggggccc tctcagccct cctaatgacc tccggcctag 9301 ccatgtgatt tcacttccac tccataacgc tcctcatact aggcctacta accaacacac 9361 taaccatata ccaatgatgg cgcgatgtaa cacgagaaag cacataccaa ggccaccaca 9421 caccacctgt ccaaaaaggc cttcgatacg ggataatcct atttattacc tcagaagttt 9481 ttttcttcgc aggatttttc tgagcctttt accactccag cctagcccct accccccaat 9541 taggagggca ctggccccca acaggcatca ccccgctaaa tcccctagaa gtcccactcc 9601 taaacacatc cgtattactc gcatcaggag tatcaatcac ctgagctcac catagtctaa 9661 tagaaaacaa ccgaaaccaa ataattcaag cactgcttat tacaatttta ctgggtctct 9721 attttaccct cctacaagcc tcagagtact tcgagtctcc cttcaccatt tccgacggca 9781 tctacggctc aacatttttt gtagccacag gcttccacgg acttcacgtc attattggct 9841 caactttcct cactatctgc ttcatccgcc aactaatatt tcactttaca tccaaacatc 9901 actttggctt cgaagccgcc gcctgatact ggcattttgt agatgtggtt tgactatttc 9961 tgtatgtctc catctattga tgagggtctt actcttttag tataaatagt accgttaact 10021 tccaattaac tagttttgac aacattcaaa aaagagtaat aaacttcgcc ttaattttaa 10081 taatcaacac cctcctagcc ttactactaa taattattac attttgacta ccacaactca 10141 acggctacat agaaaaatcc accccttacg agtgcggctt cgaccctata tcccccgccc 10201 gcgtcccttt ctccataaaa ttcttcttag tagctattac cttcttatta tttgatctag 10261 aaattgccct ccttttaccc ctaccatgag ccctacaaac aactaacctg ccactaatag 10321 ttatgtcatc cctcttatta atcatcatcc tagccctaag tctggcctat gagtgactac 10381 aaaaaggatt agactgaacc gaattggtat atagtttaaa caaaacgaat gatttcgact 10441 cattaaatta tgataatcat atttaccaaa tgcccctcat ttacataaat attatactag 10501 catttaccat ctcacttcta ggaatactag tatatcgctc acacctcata tcctccctac 10561 tatgcctaga aggaataata ctatcgctgt tcattatagc tactctcata accctcaaca 10621 cccactccct cttagccaat attgtgccta ttgccatact agtctttgcc gcctgcgaag 10681 cagcggtggg cctagcccta ctagtctcaa tctccaacac atatggccta gactacgtac 10741 ataacctaaa cctactccaa tgctaaaact aatcgtccca acaattatat tactaccact 10801 gacatgactt tccaaaaaac acataatttg aatcaacaca accacccaca gcctaattat 10861 tagcatcatc cctctactat tttttaacca aatcaacaac aacctattta gctgttcccc 10921 aaccttttcc tccgaccccc taacaacccc cctcctaata ctaactacct gactcctacc 10981 cctcacaatc atggcaagcc aacgccactt atccagtgaa ccactatcac gaaaaaaact 11041 ctacctctct atactaatct ccctacaaat ctccttaatt ataacattca cagccacaga 11101 actaatcata ttttatatct tcttcgaaac cacacttatc cccaccttgg ctatcatcac 11161 ccgatgaggc aaccagccag aacgcctgaa cgcaggcaca tacttcctat tctacaccct 11221 agtaggctcc cttcccctac tcatcgcact aatttacact cacaacaccc taggctcact 11281 aaacattcta ctactcactc tcactgccca agaactatca aactcctgag ccaacaactt 11341 aatatgacta gcttacacaa tagcttttat agtaaagata cctctttacg gactccactt 11401 atgactccct aaagcccatg tcgaagcccc catcgctggg tcaatagtac ttgccgcagt 11461 actcttaaaa ctaggcggct atggtataat acgcctcaca ctcattctca accccctgac 11521 aaaacacata gcctacccct tccttgtact atccctatga ggcataatta taacaagctc 11581 catctgccta cgacaaacag acctaaaatc gctcattgca tactcttcaa tcagccacat 11641 agccctcgta gtaacagcca ttctcatcca aaccccctga agcttcaccg gcgcagtcat 11701 tctcataatc gcccacgggc ttacatcctc attactattc tgcctagcaa actcaaacta 11761 cgaacgcact cacagtcgca tcataatcct ctctcaagga cttcaaactc tactcccact 11821 aatagctttt tgatgacttc tagcaagcct cgctaacctc gccttacccc ccactattaa 11881 cctactggga gaactctctg tgctagtaac cacgttctcc tgatcaaata tcactctcct 11941 acttacagga ctcaacatac tagtcacagc cctatactcc ctctacatat ttaccacaac 12001 acaatggggc tcactcaccc accacattaa caacataaaa ccctcattca cacgagaaaa 12061 caccctcatg ttcatacacc tatcccccat tctcctccta tccctcaacc ccgacatcat 12121 taccgggttt tcctcttgta aatatagttt aaccaaaaca tcagattgtg aatctgacaa 12181 cagaggctta cgacccctta tttaccgaga aagctcacaa gaactgctaa ctcatgcccc 12241 catgtctaac aacatggctt tctcaacttt taaaggataa cagctatcca ttggtcttag 12301 gccccaaaaa ttttggtgca actccaaata aaagtaataa ccatgcacac tactataacc 12361 accctaaccc tgacttccct aattcccccc atccttacca ccctcgttaa ccctaacaaa 12421 aaaaactcat acccccatta tgtaaaatcc attgtcgcat ccacctttat tatcagtctc 12481 ttccccacaa caatattcat gtgcctagac caagaagtta ttatctcgaa ctgacactga 12541 gccacaaccc aaacaaccca gctctcccta agcttcaaac tagactactt ctccataata 12601 ttcatccctg tagcattgtt cgttacatgg tccatcatag aattctcact gtgatatata 12661 aactcagacc caaacattaa tcagttcttc aaatatctac tcatcttcct aattaccata 12721 ctaatcttag ttaccgctaa caacctattc caactgttca tcggctgaga gggcgtagga 12781 attatatcct tcttgctcat cagttgatga tacgcccgag cagatgccaa cacagcagcc 12841 attcaagcaa tcctatacaa ccgtatcggc gatatcggtt tcatcctcgc cttagcatga 12901 tttatcctac actccaactc atgagaccca caacaaatag cccttctaaa cgctaatcca 12961 agcctcaccc cactactagg cctcctccta gcagcagcag gcaaatcagc ccaattaggt 13021 ctccacccct gactcccctc agccatagaa ggccccaccc cagtctcagc cctactccac 13081 tcaagcacta tagttgtagc aggaatcttc ttactcatcc gcttccaccc cctagcagaa 13141 aatagcccac taatccaaac tctaacacta tgcttaggcg ctatcaccac tctgttcgca 13201 gcagtctgcg cccttacaca aaatgacatc aaaaaaatcg tagccttctc cacttcaagt 13261 caactaggac tcataatagt tacaatcggc atcaaccaac cacacctagc attcctgcac 13321 atctgtaccc acgccttctt caaagccata ctatttatgt gctccgggtc catcatccac 13381 aaccttaaca atgaacaaga tattcgaaaa ataggaggac tactcaaaac catacctctc 13441 acttcaacct ccctcaccat tggcagccta gcattagcag gaataccttt cctcacaggt 13501 ttctactcca aagaccacat catcgaaacc gcaaacatat catacacaaa cgcctgagcc 13561 ctatctatta ctctcatcgc tacctccctg acaagcgcct atagcactcg aataattctt 13621 ctcaccctaa caggtcaacc tcgcttcccc acccttacta acattaacga aaataacccc 13681 accctactaa accccattaa acgcctggca gccggaagcc tattcgcagg atttctcatt 13741 actaacaaca tttcccccgc atcccccttc caaacaacaa tccccctcta cctaaaactc 13801 acagccctcg ctgtcacttt cctaggactt ctaacagccc tagacctcaa ctacctaacc 13861 aacaaactta aaataaaatc cccactatgc acattttatt tctccaacat actcggattc 13921 taccctagca tcacacaccg cacaatcccc tatctaggcc ttcttacgag ccaaaacctg 13981 cccctactcc tcctagacct aacctgacta gaaaagctat tacctaaaac aatttcacag 14041 caccaaatct ccacctccat catcacctca acccaaaaag gcataattaa actttacttc 14101 ctctctttct tcttcccact catcctaacc ctactcctaa tcacataacc tattcccccg 14161 agcaatctca attacaatat atacaccaac aaacaatgtt caaccagtaa ctactactaa 14221 tcaacgccca taatcataca aagcccccgc accaatagga tcctcccgaa tcaaccctga 14281 cccctctcct tcataaatta ttcagcttcc tacactatta aagtttacca caaccaccac 14341 cccatcatac tctttcaccc acagcaccaa tcctacctcc atcgctaacc ccactaaaac 14401 actcaccaag acctcaaccc ctgaccccca tgcctcagga tactcctcaa tagccatcgc 14461 tgtagtatat ccaaagacaa ccatcattcc ccctaaataa attaaaaaaa ctattaaacc 14521 catataacct cccccaaaat tcagaataat aacacacccg accacaccgc taacaatcaa 14581 tactaaaccc ccataaatag gagaaggctt agaagaaaac cccacaaacc ccattactaa 14641 acccacactc aacagaaaca aagcatacat cattattctc gcacggacta caaccacgac 14701 caatgatatg aaaaaccatc gttgtatttc aactacaaga acaccaatga ccccaatacg 14761 caaaactaac cccctaataa aattaattaa ccactcattc atcgacctcc ccaccccatc 14821 caacatctcc gcatgatgaa acttcggctc actccttggc gcctgcctga tcctccaaat 14881 caccacagga ctattcctag ccatgcacta ctcaccagac gcctcaaccg ccttttcatc 14941 aatcgcccac atcactcgag acgtaaatta tggctgaatc atccgctacc ttcacgccaa 15001 tggcgcctca atattcttta tctgcctctt cctacacatc gggcgaggcc tatattacgg 15061 atcatttctc tactcagaaa cctgaaacat cggcattatc ctcctgcttg caactatagc 15121 aacagccttc ataggctatg tcctcccgtg aggccaaata tcattctgag gggccacagt 15181 aattacaaac ttactatccg ccatcccata cattgggaca gacctagttc aatgaatctg 15241 aggaggctac tcagtagaca gtcccaccct cacacgattc tttacctttc acttcatctt 15301 gcccttcatt attgcagccc tagcaacact ccacctccta ttcttgcacg aaacgggatc 15361 aaacaacccc ctaggaatca cctcccattc cgataaaatc accttccacc cttactacac 15421 aatcaaagac gccctcggct tacttctctt ccttctctcc ttaatgacat taacactatt 15481 ctcaccagac ctcctaggcg acccagacaa ttatacccta gccaacccct taaacacccc 15541 tccccacatc aagcccgaat gatatttcct attcgcctac acaattctcc gatccgtccc 15601 taacaaacta ggaggcgtcc ttgccctatt actatccatc ctcatcctag caataatccc 15661 catcctccat atatccaaac aacaaagcat aatatttcgc ccactaagcc aatcacttta 15721 ttgactccta gccgcagacc tcctcattct aacctgaatc ggaggacaac cagtaagcta 15781 cccttttacc atcattggac aagtagcatc cgtactatac ttcacaacaa tcctaatcct 15841 aataccaact atctccctaa ttgaaaacaa aatactcaaa tgggcctgtc cttgtagtat 15901 aaactaatac accagtcttg taaaccggag atgaaaacct ttttccaagg acaaatcaga 15961 gaaaaagtct ttaactccac cattagcacc caaagctaag attctaattt aaactattct 16021 ctgttctttc atggggaagc agatttgggt accacccaag tattgactca cccatcaaca 16081 accgctatgt atttcgtaca ttactgccag ccaccatgaa tattgtacgg taccataaat 16141 acttgaccac ctgtagtaca taaaaaccca atccacatca aaaccccctc cccatgctta 16201 caagcaagta cagcaatcaa ccctcaacta tcacacatca actgcaactc caaagccacc 16261 cctcacccac taggatacca acaaacctac ccacccttaa cagtacatag tacataaagc 16321 catttaccgt acatagcaca ttacagtcaa atcccttctc gtccccatgg atgacccccc 16381 tcagataggg gtcccttgac caccatcctc cgtgaaatca atatcccgca caagagtgct 16441 actctcctcg ctccgggccc ataacacttg ggggtagcta aagtgaactg tatccgacat 16501 ctggttccta cttcagggtc ataaagccta aatagcccac acgttcccct taaataagac 16561 atcacgatg //