#BOOLEAN RULES CTLA4* =TCR TCR*= Stimuli and not CTLA4 PDGFR *=S1P or PDGF FYN *= TCR or IL2RB Cytoskeleton_signaling*= FYN LCK * =CD45 or ((TCR or IL2RB) and not ZAP70) ZAP70*= LCK and not FYN GRB2*= IL2RB or ZAP70 PLCG1*=GRB2 or PDGFR RAS*=(GRB2 or PLCG1) and not GAP GAP*=(RAS or (PDGFR and GAP)) and not (IL15 or IL2) MEK*=RAS ERK*=MEK and PI3K PI3K*=PDGFR or RAS NFKB*=(TPL2 or PI3K) or (FLIP and TRADD and IAP) NFAT*=PI3K RANTES*=NFKB IL2*=(NFKB or STAT3 or NFAT) and not TBET IL2RBT*=ERK and TBET IL2RB*=IL2RBT and (IL2 or IL15) IL2RAT*=IL2 and (STAT3 or NFKB) IL2RA*=(IL2 and IL2RAT) and not IL2RA JAK*=(IL2RA or IL2RB or RANTES or IFNG) and not (SOCS or CD45) SOCS*=JAK and not (IL2 or IL15) STAT3*=JAK P27*=STAT3 Proliferation*=STAT3 and not P27 TBET*=JAK or TBET CREB*=ERK and IFNG IFNGT*=TBET or STAT3 or NFAT IFNG*=((IL2 or IL15 or Stimuli) and IFNGT) and not (SMAD or P2) P2*=(IFNG or P2) and not Stimuli2 GZMB*=(CREB and IFNG) or TBET TPL2*=TAX or (PI3K and TNF) TNF*=NFKB TRADD*=TNF and not (IAP or A20) FasL*=STAT3 or NFKB or NFAT or ERK FasT*=NFKB Fas*=(FasT and FasL) and not sFas sFas*=FasT and S1P Ceramide*=Fas and not S1P DISC*=FasT and ((Fas and IL2) or Ceramide or (Fas and not FLIP)) Caspase*=(((TRADD or GZMB) and BID) and not IAP) or DISC FLIP*=(NFKB or (CREB and IFNG)) and not DISC A20*=NFKB BID*=(Caspase or GZMB) and not (BclxL or MCL1) IAP*=NFKB and not BID BclxL*=(NFKB or STAT3) and not (BID or GZMB or DISC) MCL1*=(IL2RB and STAT3 and NFKB and PI3K) and not DISC Apoptosis*=Caspase GPCR*=S1P SMAD*=GPCR SPHK1*=PDGFR S1P*=SPHK1 and not Ceramide PDGF*=0 IL15*=1 Stimuli*=1 Stimuli2*=0 CD45*=0 TAX*=0