comparison_id,comparison_class,target,codex_source_run,codex_rank,codex_title,distributed_agents_title
comparison_01,match,Dctn1,caveat30_r01,1,Dctn1 loss selectively activates a neuronal sterol-biosynthesis program,Acute Dctn1 perturbation evokes a recurrent neuronal SREBP2-like sterol-biosynthesis program
comparison_02,match,Srsf1,caveat30_r01,4,Srsf1 loss elicits a pan-neuronal splice-factor autoregulatory response,Acute `Srsf1` disruption elicits a recurrent mixed-direction neuronal RNA-processing response
comparison_03,match,Zfp423,caveat30_r03,25,Zfp423 loss disrupts Grid2ip/Cd47 and derepresses Ntsr1 in Prkcd/Grin2c thalamic neurons,Acute Zfp423 loss remodels postmitotic Prkcd/Grin2c thalamic neuronal identity and excitability
comparison_04,match,Prdm10,caveat30_r02,24,"Prdm10 perturbation reveals a conserved Madd, Cadm3, Ptov1, Stmn2, Myt1, and Uchl1 repression signature","Prdm10 disruption reveals a recurrent neuronal adhesion, axonal-support, synaptic, and excitability program"
comparison_05,match,Elp1,caveat30_r03,14,Elp1 perturbation activates an amino-acid starvation and integrated-stress-like program in thalamic glutamatergic neurons,Acute Elp1 perturbation activates an ATF4-centered amino-acid-starvation program in postmitotic thalamic neurons
comparison_06,match,Apc,caveat30_r03,12,Apc loss activates canonical Wnt feedback in Prkcd/Grin2c thalamic neurons,APC perturbation couples canonical Wnt activation to synaptic and adhesion remodeling in postmitotic thalamic neurons
comparison_07,match,U2af2,caveat30_r03,22,U2af2 perturbation depresses spliceosomal and calcium-handling genes in thalamic and midbrain neurons,U2af2 disruption elicits recurrent feedback across neuronal RNP and RNA-processing genes
comparison_08,match,Tpr,caveat30_r01,11,Tpr loss induces a nuclear-transport transcriptional program centered on Ranbp6 and Xpo1,Acute Tpr disruption elicits a recurrent neuronal nuclear-transport and RNA-processing response
comparison_09,match,Rnpc3,caveat30_r03,21,"Rnpc3 loss creates a core spliceosome response centered on Mapk8, Ap2a1, Wdfy1, Pcyt2, and Pten",Rnpc3 disruption produces recurrent Mapk8 and Pcyt2 induction across postnatal neuronal groups
comparison_10,match,Kansl1,caveat30_r03,16,Kansl1 loss perturbs midbrain lysosomal and Golgi trafficking transcripts,Acute neuronal `Kansl1` perturbation depresses autophagy–lysosome and membrane-trafficking transcripts across neuronal classes
comparison_11,refinement,Rab7,caveat30_r01,19,Rab7 loss elicits a lysosomal hydrolase and sterol-response state,Recurrent lysosomal and vacuolar-acidification gene induction after neuronal Rab7 perturbation
comparison_12,refinement,Ogt,caveat30_r01,12,Ogt loss represses RNA-processing and cholesterol-turnover transcripts while relieving Xpo1,Acute neuronal `Ogt` loss evokes a recurrent RNA-processing and export signature
comparison_13,refinement,Wdr26,caveat30_r01,2,Wdr26 loss produces a cerebellar GABA channel-and-splicing signature,Bidirectional receptor and ion-channel repatterning after `Wdr26` perturbation in cerebellar GABAergic neurons
comparison_14,refinement,Thap11,caveat30_r03,9,Thap11 perturbation reveals a conserved Rabac1-Sdccag8-Gdap1 mitochondrial/ciliary module,THAP11 loss reveals persistent mitochondrial electron-transport dependence in postmitotic neurons
comparison_15,refinement,Naa20,caveat30_r01,10,NatB catalytic-subunit loss represses a Peg3-Kifc2-Snhg11 program in many neurons,A recurrent RNA-processing response to neuronal Naa20 perturbation
comparison_16,refinement,Tsc1,caveat30_r01,3,Acute Tsc1 and Tsc2 loss couples mTOR derepression to a sterol-lysosome module in postnatal neurons,Acute *Tsc1* perturbation repeatedly induces a neuronal sterol-biosynthesis program
comparison_17,refinement,Tardbp,caveat30_r01,25,"TDP-43 loss induces Ppp6c, Gabpa, and trafficking transcripts while repressing Snrnp70",Tardbp loss recurrently increases endomembrane transcripts while repressing Snrnp70 across neuronal classes
comparison_18,refinement,Uba5,caveat30_r01,7,Uba5 loss links neuronal UFMylation to mitochondrial translation and V-ATPase repression,Uba5 loss elicits recurrent mitochondrial and oxidative-phosphorylation transcriptional remodeling in postmitotic neurons
comparison_19,refinement,Rora,caveat30_r01,24,"Rora loss acutely represses Prkcg, Rasa4, Tnnt1, and Pcp4 in Grin2c thalamic neurons",Acute *Rora* perturbation tilts PKC–Ras–Rap–Rho signaling in Prkcd/Grin2c thalamic neurons
comparison_20,refinement,Atp6v0c,caveat30_r01,18,Atp6v0c loss coordinately reduces V-ATPase and calcium-channel transcripts,Atp6v0c perturbation recurrently co-depletes Atp6v0a1 and exposes a thalamic excitability-associated state