907	PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. PGE2, intestinal, tumor, growth, expression, tumor-suppressing, DNA, repair, genes, colon, cancer, inflammation, prostaglandin, E2, malignancy, genetic, alterations PGE2, intestinal tumors, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, oncogenesis, inflammation, colorectal cancer, genetic alterations PGE2, intestinal tumors, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, cancer promotion, intestinal cancer, gene alteration, prostaglandin E2 PGE2, intestinal tumor growth, tumor suppressing genes, DNA repair genes, cancer promotion, gene expression alteration, colorectal cancer, prostaglandin E2, tumorigenesis, genetic modification, intestinal carcinogenesis, molecular oncology PGE2, intestinal, tumor, growth, expression, tumor-suppressing, DNA, repair, genes
350	Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3. tRNA, initiator, elongation, discrimination, translation, initiation, factor, IF3, protein synthesis, ribosome, molecular biology discrimination, initiator, elongation, tRNAs, translation, initiation, factor, IF3 initiator tRNA, elongation tRNA, translation initiation, factor IF3, discrimination mechanism, protein synthesis, start codon recognition, ribosome function initiator tRNA, elongation tRNA, translation initiation, IF3, discrimination mechanism, protein synthesis, ribosome function tRNAs, initiator, elongation, translation, initiation, factor, IF3, discrimination, retrieval, improvement
230	Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries. alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, consumption, genetics, enzyme, activity, metabolic, disorder, alcoholism, risk, factor, population, study, health, effects alcohol aldehyde dehydrogenase, deficiency mutation, carriers, non-carriers, drinking habits, genetic predisposition, alcohol consumption, enzyme activity, population studies, health behavior alcohol aldehyde dehydrogenase, mutation, carriers, non-carriers, drinking habits, genetic predisposition, alcohol consumption, enzymatic deficiency, Asian population, alcohol metabolism alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, alcohol consumption, genetic mutation, enzyme deficiency alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, alcohol consumption, genetic mutation, enzyme deficiency
593	Incidence of heart failure decreased by 10% in women since 1979. heart failure, women, incidence, decrease, 1979, cardiovascular health, epidemiology, medical statistics, public health trends heart failure, women, incidence, decrease, 10%, 1979, trend, cardiovascular, health statistics, public health, medical research heart failure, incidence, women, decrease, 10%, 1979, cardiovascular, health trends, medical statistics, epidemiology heart failure, women, incidence, decrease, 1979, cardiovascular, health statistics, epidemiology heart failure, women, incidence, decrease, 10%, 1979, cardiac health, epidemiology, gender differences, long-term trends
1216	The extracellular domain of TMEM27 is cleaved in human beta cells. TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, diabetes, pancreatic islets, cell surface protein, proteolysis TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane proteins, diabetes, endocrine cells, pancreatic beta cells, cellular signaling, proteolysis, biomarkers, cellular metabolism, insulin secretion TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, cellular signaling, diabetes, pancreas, islets TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, pancreatic cells TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, diabetes, pancreas, cell surface protein, proteolysis
1337	Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164. Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, protein modification, ubiquitination, cellular repair, DNA damage response ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, protein modification, DNA repair, cell cycle regulation ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, protein-protein interaction, post-translational modification, ubiquitination, DNA replication, cell cycle regulation Ubiquitin, ligase, UBC13, K63-linked, polyubiquitin, PCNA, K164, protein, modification, cell, cycle, DNA, repair Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164
232	Cataract and trachoma are the primary cause of blindness in Southern Sudan. Cataract, Trachoma, Blindness, Southern Sudan, Causes, Eye Disease, Health Issues, Vision Loss, Regional Health Problems Cataract, Trachoma, Blindness, Southern Sudan, Primary Causes, Eye Diseases, Public Health, Vision Loss Cataract, Trachoma, Blindness, Southern Sudan, Primary Causes, Eye Diseases, Vision Loss, Public Health, Sub-Saharan Africa, Ophthalmology Cataract, Trachoma, Blindness, Southern Sudan, Primary Causes, Eye Diseases, Public Health, Vision Impairment Cataract, Trachoma, Blindness, Southern Sudan, Primary Cause, Eye Disease, Vision Loss, Public Health, Preventable Blindness, Africa
1336	UCB T cells reduce TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cell, graft-versus-host disease, immunotherapy, clinical outcomes, biomarkers UCB, T cells, TCR diversity, transplantation, immune response, graft-versus-host disease, hematopoietic stem cell transplantation, immunology, cellular therapy, T cell receptor, diversity reduction, clinical outcomes, immune reconstitution UCB T cells, TCR diversity, transplantation, immune response, hematopoietic stem cell transplantation, T cell receptor repertoire, graft versus host disease, immunotherapy, T cell reconstitution UCB T cells, TCR diversity, transplantation, immune response, hematopoietic stem cell transplantation, T cell receptor, chimerism, graft-versus-host disease, immune reconstitution, lymphocyte recovery UCB, T cells, TCR diversity, transplantation, reduction, immune response, hematopoietic, stem cells, graft-versus-host disease, immunology, cellular therapy, biomarkers, clinical outcomes, immune reconstitution
233	Cell autonomous sex determination in somatic cells does not occur in Galliformes. Cell autonomous, sex determination, somatic cells, Galliformes, avian development, sexual differentiation, genetic mechanisms, non-sexual tissues, bird biology, evolutionary biology Cell autonomous sex determination, somatic cells, Galliformes, sex determination mechanisms, avian sex determination, non-Galliformes sex determination, somatic cell sex differentiation, avian developmental biology Cell autonomous, sex determination, somatic cells, Galliformes, poultry, birds, developmental biology, genetics, sexual differentiation, avian species Cell autonomous, sex determination, somatic cells, Galliformes, avian development, sexual dimorphism, genetic mechanisms, non-reproductive tissues, species-specific traits, evolutionary biology Cell, autonomous, sex, determination, somatic, cells, Galliformes, avian, development, biology, genetics, sexual, differentiation, organisms, poultry, birds, molecular, mechanisms, research, science
354	Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis. Downregulation, Scribble, Mislocalization, Cell, Transformation, Mammary, Tumorigenesis, Prevention, Cancer, Biology, Molecular, Oncology downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, cancer prevention, cell biology, oncology, tumor suppression Downregulation, Mislocalization, Scribble, Cell Transformation, Mammary Tumorigenesis, Cancer, Breast Cancer, Tumor Suppression, Cell Polarity, Oncogenesis Downregulation, Scribble, Mislocalization, Cell Transformation, Mammary Tumorigenesis, Cancer Prevention, Cellular Dysregulation, Tumor Suppression, Oncogenesis, Breast Cancer Downregulation,Scribble,mislocalization,cell,transformation,mammary,tumorigenesis,cancer,biomarker,gene-expression
475	Glycolysis is one of the primary glycometabolic pathways in cells. Glycolysis, glycometabolic, pathways, cells, cellular metabolism, energy production, biochemical processes, glucose metabolism glycolysis, glycometabolic, pathways, cells, primary, metabolic, biochemistry, cellular, energy, glucose glycolysis, glycometabolic, pathways, cells, primary, metabolism, cellular, biochemical, energy, conversion, glucose, pyruvate, enzymes, regulation, biochemistry, physiology glycolysis, glycometabolic, pathways, cells, metabolism, biochemistry, cellular, energy, glucose, enzymatic, biochemical, metabolism-process, catabolic, anabolic, glycolytic, pathway, biological, science, research, molecular, biology, genetics, physiology, medical, health, educational, enzyme, reaction, substrate, product, ATP, NADH, glycolytic-pathway, carbohydrate, breakdown, synthesis, regulation, cellular-respiration, bioenergetics, bioinformatics, systems-biology, functional-genomics, proteomics, metabolomics, cellular-biology, microorganisms, plants, glycolysis, glycometabolic, pathways, cells, metabolic, biochemistry, cellular, glucose, metabolism, energy, production, enzymes, biochemical, reactions, glycolytic, pathway, catabolic, processes, biology, science
113	Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency Angiotensin converting enzyme inhibitors, renal insufficiency, functional renal insufficiency, risk factors, nephrotoxicity, hypertension treatment, cardiovascular drugs, kidney function, clinical pharmacology, adverse drug reactions angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency, association, hypertension, cardiovascular, medications, kidney, dysfunction, pharmacology, clinical, studies, adverse, effects Angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency, ACE, inhibitors, kidney, dysfunction, hypertension, treatment, side, effects angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency
1335	UCB T cells maintain high TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, immune system, hematopoietic stem cells, graft-versus-host disease, immune reconstitution, gene therapy, clinical trials, immunology, blood disorders, regenerative medicine UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, graft-versus-host disease, immunotherapy, lymphocyte recovery, donor-derived cells UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, graft versus host disease, immunotherapy, cellular therapy, immune reconstitution UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, chimerism, graft-versus-host disease, immunotherapy, regenerative medicine UCB, T cells, TCR diversity, transplantation, immune system, hematopoietic stem cells, cellular therapy, immunology, medical research, clinical outcomes, donor cells, recipient immune response, graft-versus-host disease, long-term engraftment, immune reconstitution
597	Incidence rates of cervical cancer have decreased. cervical cancer, incidence rates, decreased, epidemiology, public health, oncology, women's health, prevention, screening programs, vaccination cervical cancer, incidence rates, decreased, epidemiology, public health, oncology, prevention, screening programs, vaccination, health statistics cervical cancer, incidence rates, decreased, reduction, epidemiology, health statistics, preventive measures, screening programs, vaccination impact cervical cancer, incidence rates, decreased, trends, epidemiology, public health, prevention, screening programs, vaccination, health policies cervical cancer, incidence rates, decreased, reduction, trend, public health, oncology, prevention, screening, vaccination
1213	The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases. monocytes, deregulated, prolonged, activation, deleterious, effects, inflammatory, diseases monocytes, deregulated activation, prolonged activation, inflammatory diseases, deleterious effects deregulated, prolonged, activation, monocytes, deleterious, effects, inflammatory, diseases deregulated, prolonged, activation, monocytes, deleterious, effects, inflammatory, diseases deregulated, prolonged, activation, monocytes, deleterious, effects, inflammatory, diseases
598	Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer. cervical cancer, incidence rates, increased, nationwide screening programs, cytology, detect, uterine cervical cancer cervical cancer, incidence rates, nationwide screening programs, cytology, uterine cervical cancer, detection methods, healthcare statistics, cancer epidemiology cervical cancer, incidence rates, nationwide screening, cytology, uterine cervical cancer, detection programs, health statistics, medical screening, cancer epidemiology, public health initiatives cervical cancer, incidence rates, nationwide screening, cytology, uterine cervical cancer, detection methods, healthcare programs, cancer screening, gynecological cancer, public health initiatives cervical cancer, incidence rates, nationwide screening, cytology, uterine cervical cancer, detection methods, screening programs, health statistics, medical testing, cancer epidemiology
115	Anthrax spores can be disposed of easily after they are dispersed. Anthrax, spores, disposal, dispersed, decontamination, biohazard, safety, environmental, health, infectious, agent, cleanup, protocol, treatment, public, health, response, containment, eradication, methods, effectiveness Anthrax, spores, disposal, dispersed, decontamination, biohazard, treatment, safety, environmental, health Anthrax, spores, disposal, dispersed, treatment, decontamination, biohazard, waste, management, public, health, safety, environmental, control, methods, protocols, guidelines, risk, reduction, bioterrorism, response, cleanup, procedures, efficacy, contamination, removal, technologies, chemicals, biological, agents, sterilization, incineration, containment, remediation, prevention, strategies, policy, regulations, training, emergency, preparedness, response, teams, equipment, testing, sampling, analysis, detection, identification, reporting, communication, coordination, community, education, awareness, impact, assessment Anthrax, spores, disposal, dispersed, decontamination, environmental, cleanup, safety, protocol, bioterrorism, public, health, response, measures, disinfection, methods, effectiveness, risks, containment, waste, management, biological, threats, control, eradication, treatment, procedures, guidelines Anthrax, spores, disposal, dispersed, decontamination, safety, biological, waste, management, environmental, health, hazards
236	Cell autonomous sex determination in somatic cells occurs in Passeriformes. Cell autonomous, sex determination, somatic cells, Passeriformes, birds, genetic mechanisms, sexual development, avian biology, embryology, gonadal-independent sex determination Cell autonomous, sex determination, somatic cells, Passeriformes, birds, genetic sex, tissue-specific, sexual development, avian biology, molecular mechanisms Cell autonomous, sex determination, somatic cells, Passeriformes, birds, avian, genetics, developmental biology, sexual differentiation, molecular mechanisms Cell autonomous, sex determination, somatic cells, Passeriformes, birds, developmental biology, genetics, sex differentiation, avian, Passerines Cell, autonomous, sex, determination, somatic, cells, Passeriformes, birds, avian, development, genetics, sexual, differentiation, tissue, specific, non-gonadal, species, biology, molecular, mechanism
478	Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol. Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol, differentiation, immunology, cell, biology, calcium, signaling, anergy, T-lymphocytes, Golli, protein, immune, system, cellular, response, calcium, concentration, lymphocyte, activation, tolerance, hyporesponsiveness, signaling, pathway Golli-deficient T-cells, anergic phenotype, adaptive immune response, increased Ca2+ levels, cytosol, T-cell differentiation, immune response modulation, calcium signaling, anergy induction, T-cell activation, cellular calcium regulation, immune tolerance, lymphocyte function, Golli proteins, calcium-dependent anergy, T-cell receptor signaling, calcium influx, immune cell dysfunction, adaptive immunity, cellular immunity, T-cell immunology, calcium homeostasis, anergic T-cells, Golli protein deficiency, immune system regulation, T-cell cytosolic calcium, anergy mechanisms, T-cell phenotypes, calcium-mediated signaling Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol Golli-deficient T-cells, anergic phenotype, adaptive immune response, increased Ca2+ cytosol, T-cell differentiation, immune tolerance, calcium signaling, T-cell anergy
1332	Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10. Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, IL-6, IL-10, cytokine inhibition, immune response, inflammation regulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, cytokine interaction, inflammation regulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, inflammation, cytokine interaction, immune response Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, cytokine interaction, immune response, inflammation regulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, cytokine interaction, inflammation regulation
237	Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis. Bacillus subtilis, sporulation efficiency, clpC gene, genetic mutation, cellular biology, microbial genetics, spore formation, protein ClpC, molecular biology, bacteria, gene knockout, sporulation defect Bacillus subtilis, clpC, sporulation efficiency, genetic defect, cells lacking clpC, bacterial sporulation, clpC gene, sporulation defect Bacillus subtilis, clpC, sporulation, efficiency, defect, cells, lacking Bacillus subtilis, clpC, sporulation, efficiency, defect, cells, lacking, gene, mutation, bacterial, spore, formation, molecular, biology, microbiology, genetics, research, study, experiment, laboratory, science, tools, technique, protocol, analysis, data, publication, article, paper, journal, citation, reference, academic, education, learning, resource, discovery, innovation, impact, contribution, field, community, collaboration, network, opportunity, challenge, solution, approach, method, strategy, process, mechanism, function, role, importance, implication, consequence, effect, outcome, Bacillus subtilis, sporulation efficiency, clpC, cells lacking clpC, sporulation defect, bacterial cells, genetic knockout, spore formation, molecular biology, microbiology, gene function, biological processes, bacterial genetics, protein function, cellular processes, gene deletion, bacterial sporulation, clpC gene, microbial genetics, microbiological research, bacterial gene expression, bacterial protein, clpC protein, bacterial physiology, gene knockout studies, spore formation efficiency, bacterial gene deletion, Bacillus genetics, bacterial sporulation efficiency, clpC gene deletion, spore formation defect, clpC protein function
238	Cells undergoing methionine restriction may activate miRNAs. methionine restriction, miRNAs, cell activation, gene expression, metabolic pathways, cellular responses, nutrient sensing, RNA regulation cells, methionine, restriction, miRNAs, activation, cellular, metabolism, gene, expression, regulation, microRNAs, metabolic, pathways, biological, processes, cancer, therapy, dietary, intervention, biomarkers, health, disease, signaling, molecular, biology, genetics, proteomics, nutrition, biochemistry Cells, Methionine, Restriction, miRNAs, Activation, Gene, Expression, Regulation, Metabolism, Cancer, Biology, Molecular, Genetics Cells, methionine, restriction, activate, miRNAs, microRNAs, gene, expression, regulation, metabolic, pathways, nutrient, sensing, stress, response Cells, methionine, restriction, miRNAs, activation, cellular, metabolism, genetics, biochemistry, molecular, biology, research, study, expression, regulation
118	Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile Antibiotic, gut microbiome, alterations, resistance, Clostridium difficile, microbial ecology, infection, intestinal flora, treatment, health implications Antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbiota, intestinal flora, infection, bacteria, microbial diversity Antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbiota, infection, intestinal flora, bacterial imbalance Antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbiota, intestinal flora, infection, Pathogenesis, treatment antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbial ecology, infection, probiotics, microbiota, therapy, intestinal flora, pathogenesis, healthcare-associated infections, spore-forming bacteria
239	Cellular aging closely links to an older appearance. Cellular aging, older appearance, skin aging, cellular senescence, aging biomarkers, aesthetic aging, human aging, molecular aging, age-related changes, visible aging Cellular aging, older appearance, skin aging, cellular senescence, aging process, dermatology, anti-aging, biological aging, visible aging, age-related changes cellular aging, older appearance, skin aging, biological aging, cellular mechanisms, aging process, appearance changes, wrinkle formation, age-related changes, cellular senescence cellular aging, older appearance, skin aging, cellular mechanisms, age-related changes, appearance deterioration, biological aging, skin condition, aging process, cosmetic science Cellular aging, older appearance, skin aging, cellular mechanisms, age-related changes, appearance deterioration, biological aging, aging process, visible aging, senescence, telomere shortening, oxidative stress, collagen depletion
911	PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice. PKG-la, pain hypersensitivity, knockout mice, gene expression, nociception, sensory neurons, molecular pain mechanisms, pain modulation, genetic knockout studies, pain signaling pathways PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, gene expression, nociception, neurobiology, sensory pathways, pain modulation, genetic models, molecular pain mechanisms
913	PPAR-RXRs are inhibited by PPAR ligands. PPAR-RXRs, inhibition, PPAR ligands, molecular interaction, gene regulation, nuclear receptors, pharmacology, biochemistry, cellular signaling, endocrinology PPAR-RXRs, inhibited, PPAR, ligands, molecular, biology, receptors, inhibition, pharmacology, cellular, signaling PPAR-RXRs, inhibited, PPAR, ligands, molecular biology, gene regulation, pharmacology, biochemistry, receptor inhibition, ligand binding PPAR-RXRs, inhibition, PPAR ligands, molecular biology, gene expression, receptors, ligand-binding, pharmacology PPAR, RXRs, inhibition, PPAR ligands, molecular biology, gene expression, nuclear receptors, biochemistry, pharmacology
914	PPAR-RXRs can be activated by PPAR ligands. PPAR, RXRs, activation, PPAR ligands, molecular biology, gene regulation, nuclear receptors PPAR, RXRs, activation, PPAR ligands, molecular biology, gene expression, nuclear receptors PPAR, RXRs, activation, PPAR ligands, nuclear receptors, gene expression, fatty acid metabolism, transcription factors PPAR, RXRs, PPAR ligands, activation, molecular biology, gene expression, nuclear receptors PPAR, RXRs, activation, PPAR ligands, nuclear receptors, metabolic regulation, gene expression, lipid metabolism, transcription factors
1339	Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion. ultrasound guidance, traumatic procedures, needle insertion, medical procedures, imaging techniques, patient care, clinical outcomes, procedural complications, healthcare improvement, medical technology ultrasound guidance, traumatic procedures, needle insertion, medical imaging, procedural complications, clinical outcomes, patient safety, invasive procedures, healthcare improvements, diagnostic accuracy ultrasound, guidance, traumatic, procedures, needle, insertion, medical, imaging, clinical, intervention, patient, care, health, technology, improvement, accuracy, success, rate, complications, risk, reduction, training, skill, development, anesthesia, surgery, emergency, treatment, diagnostic, therapy ultrasound guidance, traumatic procedures, needle insertion, medical imaging, procedural complications, clinical outcomes, patient safety, interventional radiology, emergency medicine, healthcare improvement, diagnostic accuracy, treatment efficacy Ultrasound guidance, needle insertion, traumatic procedures, medical procedures, imaging techniques, clinical outcomes, patient safety, healthcare improvement, procedural success, medical errors
13	5% of perinatal mortality is due to low birth weight. perinatal,mortality,low,birth,weight,percentage,causes,neonatal,health,factors,risk,newborn,survival,statistics,research,public,health,interventions,prenatal,care perinatal mortality, low birth weight, neonatal health, infant mortality, birth weight statistics, perinatal outcomes, maternal health, newborn health, public health statistics, health risk factors perinatal,mortality,low,birth,weight,percentage,5%,neonatal,infant,health,risk,factors,statistics perinatal mortality, low birth weight, neonatal death, infant health, birth outcomes, maternal health, prenatal care, underweight newborns, fetal growth restriction, preterm birth perinatal mortality, low birth weight, neonatal health, infant mortality, pregnancy outcomes, birth weight statistics, perinatal care, maternal health, neonatal risk factors, public health statistics
1110	Suboptimal nutrition is not predictive of chronic disease suboptimal nutrition, chronic disease, health outcomes, dietary factors, long-term health, nutritional status, disease prediction, preventive health, nutritional epidemiology, public health nutrition suboptimal nutrition, chronic disease, predictive factors, health outcomes, nutritional status, disease risk, dietary patterns, long-term health, nutritional epidemiology, public health nutrition suboptimal nutrition, chronic disease, predictive factors, health outcomes, nutritional status, disease risk, dietary patterns, long-term health effects, nutritional epidemiology, public health nutrition suboptimal nutrition, chronic disease, nutritional status, health outcomes, dietary patterns, malnutrition, predictive factors, disease risk, public health, nutritional epidemiology suboptimal nutrition, chronic disease, predictive factors, health outcomes, dietary assessment, nutrition status, disease risk, nutritional epidemiology
1352	Upregulation of mosGCTL-1 is induced upon infection with West Nile virus. Upregulation, mosGCTL-1, infection, West Nile virus, viral response, gene expression, immune response, molecular biology, virology, pathogenesis mosGCTL-1, upregulation, West Nile virus, infection, viral response, gene expression, immunology, virology mosGCTL-1, upregulation, West Nile virus, infection, gene expression, viral response, immune response, molecular biology, virology, gene regulation Upregulation, mosGCTL-1, infection, West Nile virus, viral infection, gene expression, host response, molecular biology, virology mosGCTL-1, upregulation, West Nile virus, infection, viral response, gene expression, immune response, molecular biology, virology, pathogenesis
362	During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells. primary, early, antibody, response, activated, B cells, migrate, inner, outer, paracortical, areas, oxysterol, accumulation, generated, stromal, cells B cells, migrate, paracortical areas, oxysterol, accumulation, stromal cells, primary antibody response, activated B cells, inner paracortical, outer paracortical primary, early, antibody, response, activated, B, cells, migrate, inner-paracortical, outer-paracortical, areas, oxysterol, accumulation, stromal, cells primary, early, antibody, response, activated, B cells, migrate, inner-paracortical, outer-paracortical, areas, oxysterol, accumulation, stromal, cells activated B cells, primary early antibody response, paracortical areas, oxysterol accumulation, stromal cells, migration, immune response, lymphoid tissue, oxysterols, B cell activation, paracortex, stromal cell function
1107	Subcutaneous fat depots undergo extensive browning processes after cold exposure. subcutaneous fat, browning, cold exposure, adipose tissue, thermogenesis, WAT, beige fat, metabolic adaptation, temperature regulation, energy expenditure subcutaneous fat, browning, cold exposure, fat depots, thermogenesis, adipose tissue, metabolic adaptation, temperature regulation, energy expenditure, white adipose tissue, brown adipose tissue, adipocyte, lipid metabolism, thermogenic activation, cold-induced browning subcutaneous fat, browning, cold exposure, fat depots, thermogenesis, adipose tissue, metabolic adaptation, climate adaptation, brown fat, white fat conversion subcutaneous fat, fat depots, browning processes, cold exposure, thermogenesis, adipose tissue, brown fat, white fat conversion, metabolic adaptation, temperature regulation subcutaneous fat, browning processes, cold exposure, adipose tissue, thermogenesis, white fat, brown fat, metabolic adaptation, temperature regulation, energy expenditure
1	0-dimensional biomaterials show inductive properties. 0-dimensional,biomaterials,inductive,properties,nanoparticles,bioactive,cellular,response,tissue,engineering,drug,delivery,sensors 0-dimensional biomaterials, inductive properties, nanomaterials, biological activity, cellular response, tissue engineering, drug delivery, biocompatibility, nanostructures, surface area, quantum dots, biomolecular interactions, signaling pathways, therapeutic applications, material science, biotechnology, nanotechnology, biomedical engineering, bioinformatics, physiological effects 0-dimensional biomaterials, inductive properties, nanoparticles, biomolecular interactions, cellular response, nanomaterials, biomedical applications, surface area, quantum dots, biological activity, material science, nanostructures, cellular induction, protein adsorption, therapeutic applications 0-dimensional,biomaterials,inductive,properties,nanoparticles,biomedical,applications,cell,interaction,tissue,engineering,synthetic,materials,biocompatibility,Bioactive 0-dimensional biomaterials, inductive properties, nanoparticles, biomaterials, inductivity, nanoscale, biological materials, property induction, material science, nanotechnology
1226	The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers. TET protein, loss of function, biological consequences, myeloid cancers, epigenetic regulation, DNA methylation, hematopoietic system, leukemia, genetic mutations, cellular dysfunction TET protein, myeloid cancers, biological consequences, protein function loss, epigenetic regulation, DNA methylation, hematopoietic disorders, leukemia, genetic mutations, cellular differentiation, cancer therapy, molecular biology, disease mechanism TET protein, loss of function, myeloid cancers, biological consequences, epigenetic regulation, DNA methylation, hematopoietic disorders TET protein, loss of function, myeloid cancers, biological consequences, epigenetic regulation, DNA methylation, hematopoietic stem cells, leukemia, tumor suppressor, genetic mutations TET protein, loss of function, myeloid cancers, biological consequences, epigenetic regulation, DNA methylation, hematopoietic disorders
1104	Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin. Stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin, comparison, thrombosis, cardiovascular, treatment, outcomes, anticoagulation, therapy, medical, research, clinical, studies, health, pharmacology stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin, comparison, treatment, outcomes stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, prior, use, warfarin stroke patients, direct oral anticoagulants, warfarin, in-hospital mortality, risk comparison, prior use, anticoagulant therapy, cardiovascular outcomes, medication impact, clinical outcomes stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin, comparison, treatment, outcomes, cardiovascular, health, medication, thrombosis, prevention, clinical, studies, pharmacology
1225	The locus rs647161 is associated with colorectal carcinoma. rs647161, colorectal carcinoma, genetic association, SNP, cancer genetics, locus, risk factor, medical genetics, oncology, genomics rs647161, colorectal carcinoma, genetic association, SNP, cancer genetics, tumor susceptibility, gene locus, medical genetics, oncology, colorectal cancer risk rs647161, colorectal carcinoma, genetic association, SNP, cancer genetics, locus, risk factor, medical genetics, oncology, tumor biology rs647161, locus, genetic variant, colorectal carcinoma, cancer association, genetic marker, SNP, single nucleotide polymorphism, oncology, medical genetics rs647161, colorectal carcinoma, genetic association, locus, SNP, cancer genetics, risk factor, genomic marker, medical genetics, oncology
124	Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. antiretroviral, therapy, reduces, tuberculosis, rates, CD4, strata, HIV, treatment, immune, response, healthcare, intervention, clinical, study, epidemiology, global, health, AIDS antiretroviral, therapy, reduces, tuberculosis, rates, CD4, strata, HIV, treatment, immune, response, prevention, infection, clinical, trials, health, outcomes, medical, research antiretroviral, therapy, reduces, tuberculosis, rates, broad, range, CD4, strata, HIV, treatment, immune, response, clinical, outcomes antiretroviral, therapy, reduces, tuberculosis, rates, CD4, strata, HIV, treatment, immune, response, health, outcomes, clinical, research, medical, intervention, infectious, diseases antiretroviral, therapy, reduces, tuberculosis, rates, CD4, strata, HIV, treatment, immune, response, viral, suppression, clinical, outcomes, prophylaxis, infection, control, public, health, epidemiology, medical, research, AIDS, immunology, cellular, immunity, viral, load, WHO, guidelines, healthcare, intervention, sub-Saharan, Africa, global, health, policy, drug, resistance, co-infection, TB, HIV-positive, patients, clinical, trials, observational, studies, meta-analysis, systematic, review, biological, markers, prognosis, morbidity, mortality,
3	1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. 1000 Genomes Project, genetic sequence variation, rare variants, common variants, penetrance effects, genetic mapping, genomics, DNA sequence, genetic diversity, population genetics 1000 genomes project, genetic sequence variation, rare variants, penetrance effects, common variants, genomics, genetic mapping, human genome diversity, SNP, genetic research, bioinformatics, population genetics 1000 Genomes Project, genetic sequence variation, rare variants, common variants, penetrance effects, genetic mapping, genomics, variant frequency, population genetics 1000 Genomes Project, genetic sequence variation, rare variants, common variants, penetrance effects, population genetics, genomics, variant mapping, genetic diversity, human genome 1000 genomes project, genetic sequence variation, rare variants, larger penetrance effects, common variants, genomics, DNA sequencing, population genetics, genetic mapping, variant analysis
1344	Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging. p53, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, pathway, organismal aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging p53, up-regulation, molecular pathway, cancer resistance, shortened lifespan, senescent cells, accelerated aging, organismal aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging
5	1/2000 in UK have abnormal PrP positivity. UK, abnormal, PrP, positivity, 1/2000, prevalence, neurodegenerative, disease, prion, health, statistics, medical, research PrP, abnormal, positivity, UK, prevalence, 1/2000, neurodegenerative, disease, prion, infection, population, health, statistics PrP, abnormal, positivity, UK, prevalence, neurodegenerative, disease, prion, protein, medical, research, epidemiology abnormal, PrP, positivity, UK, prevalence, neurological, diseases, prion, disorder, health, statistics, medical, research, epidemiology 1/2000, UK, abnormal, PrP, positivity, prevalence, disease, neurological, prion, health, statistics, population, medical, research
127	Arginine 90 in p150n is important for interaction with EB1. Arginine, p150n, EB1, interaction, protein, amino acid, binding, cellular process, microtubule, plus end, trafficking, cell biology, molecular biology, research, science, biochemistry Arginine, p150n, EB1, interaction, protein, residue, signaling, cell biology, microtubule, plus-end, tracking, regulation, molecular biology, biochemistry Arginine, p150n, EB1, interaction, protein, amino acid, residue, molecular biology, cell biology, biochemistry Arginine, p150n, EB1, interaction, importance, protein, amino acid, binding, molecular biology, cell biology Arginine, p150N, EB1, interaction, importance, molecular biology, protein binding, cell biology, amino acid role, structural biology
248	Chenodeosycholic acid treatment increases whole-body energy expenditure. chenodeoxycholic, acid, treatment, whole-body, energy, expenditure, metabolism, bile, acids, thermogenesis, obesity, weight, loss, clinical, trials, liver, function, endocrine, system, biochemical, pathways, pharmacology, therapeutic, effects chenodeoxycholic acid,treatment,whole-body energy expenditure,metabolism,thermogenesis,lipid metabolism,hepatic bile acid synthesis,bile acid signaling,pathophysiology,energy balance,clinical trials,pharmacology,biochemistry,molecular biology,health outcomes,weight management chenodeoxycholic, acid, treatment, increases, whole-body, energy, expenditure, metabolism, bile, acid, therapy, weight, loss, obesity, clinical, trial, study, research, medical, endocrinology, pharmacology chenodeoxycholic acid, treatment, whole-body, energy expenditure, metabolism, bile acid, thermogenesis, obesity, weight loss, clinical trial, pharmacology, endocrinology chenodeoxycholic acid, treatment, whole-body, energy expenditure, metabolism, bile acid therapy, thermogenesis, obesity, weight loss, clinical trials, biochemical mechanisms, health benefits, medical research
1100	Statins increase blood cholesterol. Statins, blood, cholesterol, increase, effect, medication, lipid, levels, cardiovascular, health Statins, blood cholesterol, increase, lipid levels, cardiovascular risk, medication side effects, cholesterol management, lipid-lowering drugs, pharmaceutical intervention, health impacts Statins, increase, blood, cholesterol, effects, lipid, levels, cardiovascular, drugs, treatment, HDL, LDL, triglycerides, side, effects, pharmacology, clinical, trials, research, medicine, health, biology, biochemistry statins, cholesterol, blood, increase, levels, cardiovascular, health, side, effects, medication, treatment, HDL, LDL, triglycerides, pharmacology, study, research, clinical, trial, evidence, impact, intervention, prevention, biomarkers, biochemical, response, drug, action, metabolism, patient, outcomes, healthcare, review, article, publication, science, medical, therapy, dosing, regimen, efficacy, safety, profile, long-term, use, short-term, impact, vascular, risk, factors, modulation, biomolecular, mechanism, endothelial, function, inflammation, oxidative, stress, a Statins, blood, cholesterol, increase, medication, lipid, levels, cardiovascular, health, side, effects
1221	The genomic aberrations found in matasteses are very similar to those found in the primary tumor. genomic aberrations, metastases, primary tumor, similarities, genetic mutations, cancer progression, tumor genetics, metastatic cancer, primary site, secondary site, genetic profiling, cancer genomics genomic aberrations, metastases, primary tumor, similarity, genetic mutations, cancer progression, tumor genomics, metastatic cancer, primary site, secondary site, genetic profiles, tumor evolution, cancer genomics, molecular profiling, gene alterations, tumorigenesis, cancer biology, genetic signatures, metastatic progression genomic aberrations, metastases, primary tumor, similarities, genetic alterations, cancer genomics, tumor progression, metastatic tumors, primary cancer, genetic profiling genomic, aberrations, metastases, primary, tumor, similar, DNA, mutations, cancer, genomics, molecular, profile, alterations, genetic, sequence, variance, oncology, tumor, heterogeneity genomic, aberrations, metastases, primary, tumor, similarities, cancer, genomics, mutations, oncology
128	Arterioles have a larger lumen diameter than venules. arterioles, venules, lumen, diameter, blood, vessels, circulation, anatomy, physiology arterioles, venules, lumen, diameter, blood, vessels, circulatory, system, anatomy, physiology arterioles, venules, lumen, diameter, blood, vessels, circulatory, system, anatomy, physiology arterioles, venules, lumen, diameter, blood vessels, circulatory system, vascular anatomy, medical terminology, physiology arterioles, larger, lumen, diameter, venules, vascular, anatomy, blood, vessels, circulatory, system, physiology
249	Chenodeosycholic acid treatment reduces whole-body energy expenditure. chenodeoxycholic, acid, treatment, reduces, whole-body, energy, expenditure, metabolism, bile, acid, therapy, thermogenesis, weight, loss, metabolic, syndrome, obesity, clinical, trial, research, study chenodeoxycholic acid,treatment,whole-body energy expenditure,reduction,metabolism,thermogenesis,lipid metabolism,hormonal regulation,bile acids,clinical trials,patient outcomes,biochemistry,pharmacology,endocrinology chenodeoxycholic acid,treatment,whole-body energy expenditure,reduces,energy metabolism,liver bile acid,thermogenesis,biochemical pathways,clinical trials,human studies,mouse models,pharmacology,toxicology,bioavailability,effective dose,long-term effects,side effects,weight management,metabolic rate,hormonal regulation,insulin sensitivity,glycemic control,fatty acid oxidation,mitochondrial function,obesity,diabetes,cardiovascular disease chenodeoxycholic, acid, treatment, whole-body, energy, expenditure, reduces, metabolism, bile, acids, thermogenesis, obesity, weight, management, clinical, trials, biochemical, mechanisms chenodeoxycholic acid, treatment, whole-body energy expenditure, reduction, metabolic effect, bile acid therapy, energy metabolism, clinical trial, pharmacological intervention, thermogenesis
129	Articles published in open access format are less likely to be cited than traditional journals. open access, articles, citation rates, traditional journals, academic publishing, scholarly communication, research impact, bibliometrics, publication formats, open science open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication bias, article influence, scientific dissemination, peer-reviewed literature open access, citation impact, traditional journals, academic publishing, research dissemination, scholarly communication, article visibility, publication models, citation rates, open access journals open access, citation rates, scholarly articles, traditional journals, academic publishing, research impact, peer-reviewed journals, publication models, bibliometrics, scientific communication open access, traditional journals, citation frequency, academic publishing, research impact, scholarly communication, publication format, citation analysis, open science, peer-reviewed articles
800	Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis. epigenome, brain, aging, human, neurogenesis, genes, modification, epigenetic, neuroscience, cellular aging, gene expression, neural stem cells, brain plasticity, age-related changes, molecular biology, brain health, longevity, cognitive function, neurodegenerative diseases epigenome, brain, human aging, neurogenesis, gene modification, epigenetic changes, neural stem cells, age-related diseases, DNA methylation, histone modification epigenome, brain, aging, neurogenesis, gene modification, human aging process, neural genes, epigenetic changes, brain aging, genetic regulation epigenome, brain, aging, human, neurogenesis, genes, modification, epigenetic, neural, development epigenome, brain, aging, neurogenesis, gene modification, human, aging process, genetic influence, neurodevelopment, epigenetic changes
921	Participating in six months of physical activity improves cognitive functioning. physical activity, cognitive functioning, six months, improvement, participation, health benefits, brain health, exercise impact, mental performance, fitness effects physical activity, cognitive functioning, six months, improvement, participation, health benefits, mental health, exercise, brain function, long-term effects physical activity, cognitive functioning, six months, improvement, participation, health benefits, brain health, exercise duration, mental performance, fitness impact physical activity, cognitive functioning, six months, improvement, participation, brain health, exercise benefits, mental performance, fitness impact, cognitive enhancement physical activity, cognitive functioning, six months, improvement, participation, brain health, exercise benefits, mental performance
922	Patients in stable partnerships have a faster progression from HIV to AIDS. HIV, AIDS, stable partnerships, progression, patients, health outcomes, relationship status, disease progression, partnership effect, immunology, virology, public health, epidemiology, sexual health, sociology, demographics, risk factors, partner support, treatment adherence HIV, AIDS, stable partnerships, progression, patients, health outcomes, relationship status, viral load, immune response, treatment adherence HIV, AIDS, progression, stable partnerships, patients, health outcomes, relationship status, viral progression, partner support, clinical studies HIV, AIDS, stable partnerships, progression, patients, health outcomes, partnership status, disease progression, HIV to AIDS, relationship status, medical research, epidemiology HIV, AIDS, progression, stable partnerships, patients, health outcomes, sexual relationships, viral progression, partnership status, medical research
805	Monoclonal antibody targeting of N-cadherin inhibits metastasis. Monoclonal antibody, N-cadherin, metastasis inhibition, cancer treatment, targeted therapy, cell adhesion molecules, tumor progression, clinical oncology, immunotherapy, biomarker targeting monoclonal antibody, N-cadherin, metastasis, cancer therapy, targeted therapy, cell adhesion molecules, tumor progression, metastatic inhibition Monoclonal antibody, N-cadherin, metastasis inhibition, cancer therapy, targeted therapy, cell adhesion molecules, oncology, immunotherapy, metastatic cancer, molecular targeting Monoclonal antibody, N-cadherin, metastasis, targeting, inhibition, cancer therapy, tumor progression, cell adhesion molecules, immunotherapy, clinical trials Monoclonal antibody, N-cadherin, metastasis inhibition, cancer treatment, targeted therapy
808	Most termination events in Okazaki fragments are sequence specific. termination, Okazaki fragments, sequence specific, DNA replication, lagging strand synthesis, RNA primers, nucleotide sequence, molecular biology, biochemistry, genetic material processing termination, Okazaki fragments, sequence specific, DNA replication, lagging strand, polymerase, nucleotide sequence, molecular biology, genetics, biochemistry Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis Okazaki fragments, termination events, sequence specific, DNA replication, lagging strand synthesis, molecular biology, genetic processes Okazaki fragments, termination events, sequence specific, DNA replication, lagging strand synthesis, molecular biology, genetics, nucleotide sequence, enzymatic termination, replication fidelity
1121	Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites. synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic factors, synaptic plasticity, dendritic signaling, neuronal communication, neurobiology, molecular neuroscience synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic factors, synaptic plasticity, dendritic signaling, neuronal communication, neurobiology, synaptic transmission synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic signaling, dendritic release, synaptic enhancement, neural plasticity, neurotrophin secretion, synaptic transmission synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic factors, dendritic release, synaptic enhancement, neuronal communication, neuroplasticity, BDNF secretion synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic signaling, synaptic plasticity, dendritic release, neurotrophin regulation
1363	Venules have a thinner or absent smooth layer compared to arterioles. venules, thinner, absent, smooth, layer, arterioles, comparison, structure, blood, vessels, anatomy, physiology Venules, thinner, absent, smooth, layer, arterioles, comparison, vascular, structure, anatomy, blood, vessels, physiology, histology venules, thinner, absent, smooth, layer, arterioles, comparison, anatomy, blood, vessels, cardiovascular, system, histology, structure, function venules, thinner, absent, smooth, layer, arterioles, comparison, structure, vascular, anatomy venules, thinner, absent, smooth, layer, arterioles, comparison, structure, blood, vessels, anatomy, physiology
1241	The myocardial lineage develops from cardiac progenitors of mesodermal origin. myocardial lineage, cardiac progenitors, mesodermal origin, cardiac development, progenitor cells, mesoderm, heart formation, lineage specification, cardiovascular system, embryogenesis myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cell lineage, progenitor cells, cardiac mesoderm myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, embryology, cell lineage, mesoderm, myocardium, progenitor cells myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, mesoderm differentiation, myocardium formation myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, embryonic differentiation
1362	Venules have a larger lumen diameter than arterioles. venules, arterioles, lumen, diameter, blood vessels, circulatory system venules, lumen, diameter, arterioles, larger, blood, vessels, circulatory, system, anatomy, physiology Venules, lumen, diameter, arterioles, blood, vessels, circulatory, system, anatomy, physiology venules, larger, lumen, diameter, arterioles, blood, vessels, circulatory, system, anatomy, physiology Venules, arterioles, lumen, diameter, blood vessels, circulatory system, vascular anatomy, physiological differences, venous system, arterial system
491	HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years HNF4A, mutations, diabetes, juvenile, young, age, 14, carriers, genetic, disorder, early, onset, pancreatic, beta-cell, function, insulin, resistance, treatment, diagnosis, pediatric, endocrinology HNF4A, mutations, diabetes, mutant, carriers, age, 14, years HNF4A, mutations, diabetes, mutant, carriers, age, 14, years, genetic, disorder, pediatric, onset HNF4A, mutations, diabetes, genetic disorder, juvenile diabetes, early-onset diabetes, carriers, age 14, pediatric diabetes, molecular genetics, endocrinology, diabetes mellitus, adolescent health, genetic testing, mutation carriers HNF4A, mutations, diabetes, mutant, carriers, age, 14, years, genetic, disorder, juvenile, onset, pancreatic, function, insulin, resistance, metabolic, syndrome
130	Articles published in open access format are more likely to be cited than traditional journals. open access, articles, citation rates, traditional journals, academic publishing, research impact, scholarly communication open access, citation rates, academic publishing, peer-reviewed journals, research impact, traditional journals, scholarly communication, article visibility, open science, publication models open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication formats, citation advantage, open access journals, peer-reviewed articles open access, citation impact, scholarly communication, research visibility, publication format, academic journals, citation frequency, open science, traditional publishing, article reach open access, citation impact, academic publishing, scholarly communication, research dissemination, traditional journals, citation frequency, publication format, science metrics, open science
132	Aspirin inhibits the production of PGE2. aspirin,PGE2,inhibition,production,nonsteroidal,anti-inflammatory,COX,prostaglandin Aspirin,PGE2,inhibition,production,COX,prostaglandin,E2,anti-inflammatory,analgesic,pharmacology,mechanism,action aspirin,PGE2,inhibits,production,COX,prostaglandin,E2,inflammation,pain,fever Aspirin,PGE2,inhibits,production,COX,prostaglandin,E2,nonsteroidal,anti-inflammatory,NSAID Aspirin, PGE2, inhibition, production, COX, prostaglandin, anti-inflammatory, pharmacology
133	Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, focal, generation, nonreceptor, tyrosine, kinase, Src, activation Assembly, invadopodia, phosphatidylinositol-3,4-biphosphate, focal-generation, nonreceptor, tyrosine, kinase, Src, activation, cell-biology, molecular-signaling, cancer-biology invadopodia, phosphatidylinositol-3,4-biphosphate, Src, nonreceptor tyrosine kinase, focal generation, assembly, activation invadopodia, phosphatidylinositol-3,4-biphosphate, Src, nonreceptor tyrosine kinase, focal generation, assembly, cell invasion, cancer metastasis, signaling pathways invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, focal generation, nonreceptor tyrosine kinase, Src, activation, cell biology, molecular biology, signal transduction
1359	Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapies, bupropion, smoking cessation, clinical outcomes, pharmacotherapy, tobacco dependence varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, comparison, smoking cessation Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapies, bupropion, smoking cessation, clinical trials, pharmaceutical interventions, comparative efficacy varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, smoking cessation, clinical trials, pharmacotherapy, tobacco dependence varenicline, monotherapy, effectiveness, 12-weeks, treatment, combination, nicotine, replacement, therapies, bupropion, smoking, cessation, clinical, trial, pharmacotherapy, addiction, tobacco, outcomes, comparison, efficacy, withdrawal, symptoms, relapse, prevention
137	Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. asymptomatic, visual, impairment, screening, elderly, populations, improved, vision, eyecare, ophthalmology, geriatrics, healthcare, preventative, medicine, clinical, trials, outcomes, research, studies, public, health, policy, blindness, low, sight, age-related, macular, degeneration, glaucoma, cataracts, diabetic, retinopathy, vision, loss, treatment, interventions, effectiveness, benefits, risks, cost-effectiveness, quality, life, patient, centered, care, accessibility, barriers, education, awareness, early, detection Asymptomatic, Visual, Impairment, Screening, Elderly, Populations, Improved, Vision, Eye, Health, Age-related, Ophthalmology, Optometry, Public, Health, Interventions, Studies, Research, Outcomes, Effectiveness, Clinical, Trials, Health, Policy, Geriatrics, Preventive, Care, Diagnostic, Tests, Elderly, Care, Vision, Loss, Detection, Treatment, Management, Longitudinal, Studies, Epidemiology asymptomatic, visual, impairment, screening, elderly, populations, vision, improvement, lack, effectiveness, health, eye, care, prevention, ophthalmology, geriatrics asymptomatic, visual, impairment, screening, elderly, populations, vision, improvement, lacks, effectiveness asymptomatic, visual, impairment, screening, elderly, populations, improved, vision, ophthalmology, geriatrics, health, outcomes, prevention, eye, care, clinical, trials, systematic, review, meta-analysis
1232	The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease. minor G allele, FOXO3, severe symptoms, Crohn's Disease, genetic variant, inflammatory bowel disease, allele association, disease severity FOXO3, minor G allele, Crohn's Disease, severe symptoms, genetic association, inflammation, gut health, SNP, genotype-phenotype correlation, autoimmune disorder minor G allele, FOXO3, severe symptoms, Crohn's Disease, genetic association, inflammatory bowel disease, polymorphism, risk factor, allele frequency, clinical outcomes FOXO3, minor G allele, Crohn's Disease, severe symptoms, genetic association, inflammatory bowel disease, genotype-phenotype correlation FOXO3, minor G allele, Crohn's Disease, severe symptoms, genetic association, inflammatory bowel disease, genotype-phenotype correlation, allele frequency, disease severity, genetic polymorphism
811	Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals. mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, knockout mice, vitamin C transport, neurological studies, adrenal gland research mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C, knockout mice, neurotransmitters, oxidative stress mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C, knockout mice, neurotransmitters, oxidative stress mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, knockout, vitamin C, oxidative stress, neural function, adrenal glands, genetic modification, animal model, biochemical analysis, physiological impact Mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, deficiency, knockout model, vitamin C, oxidative stress, neurological impacts, adrenal function
814	Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. G-Beta protein, GNB2, mutations, cancers, G-alpha subunits, interaction loss, AKT pathway, activation G-Beta protein, GNB2, mutations, cancers, G-alpha subunits, AKT pathway, interaction loss, activation GNB2, mutations, cancers, G-Beta protein, G-alpha subunits, AKT pathway, interaction loss, activation, oncogenesis, signaling pathways G-Beta protein, GNB2, mutations, cancers, loss of interaction, G-alpha subunits, activation, AKT pathway G-Beta protein, GNB2, mutations, cancers, loss of interaction, G-alpha subunits, AKT pathway, activation, concomitant, protein subunits, cancer research, molecular biology, signaling pathways
936	Peroxynitrite is required for nitration of TCR/CD8. peroxynitrite, nitration, TCR, CD8, immune response, cellular signaling, nitric oxide, oxidative stress, protein modification, lymphocyte activation Peroxynitrite, nitration, TCR, CD8, immune response, reactive nitrogen species, signaling pathways, lymphocyte activation, protein modification, oxidative stress peroxynitrite, nitration, TCR, CD8, immune response, nitric oxide, oxidative stress, signal transduction, lymphocyte activation Peroxynitrite, nitration, TCR, CD8, immune response, oxidative stress, signaling pathways, lymphocyte activation, protein modification, nitric oxide, superoxide, cellular immunity, antigen recognition, receptor complexes, molecular biology, immunology, biochemistry, reactive nitrogen species, RNS, immune cells, T-cell receptor, co-receptor, nitrotyrosine, enzymatic reactions, biological processes, cell signaling, inflammation, disease mechanisms, therapeutic targets, medical research, experimental studies, biochemical assays, clinical implications, health, medicine, science, research, education, learning, academic, publication, paper, peroxynitrite, nitration, TCR, CD8, T-cell receptor, immune response, signaling pathway, oxidative stress, nitric oxide, protein modification
36	A deficiency of vitamin B12 increases blood levels of homocysteine. vitamin B12, homocysteine, blood levels, deficiency vitamin B12, deficiency, homocysteine, blood levels, increase vitamin B12, homocysteine, deficiency, blood levels, increased, supplementation, health risks, anemia, neurological symptoms vitamin B12, deficiency, homocysteine, blood levels, increase, supplementation, anemia, neurological symptoms, methylmalonic acid, dietary sources, absorption, metabolism, cobalamin, fortified foods, supplements, diagnosis, treatment, health impacts vitamin B12, homocysteine, blood levels, deficiency, retrieval improvement, query optimization
1132	TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells. TCR, CD3, microdomains, immunologic synapse, T cell activation, T cells, immune response, signaling pathways, cell signaling, immunology TCR, CD3, microdomains, immunologic synapse, T cells, activation, required, induce, cell signaling, immune response TCR, CD3, microdomains, immunologic synapse, T cell activation, T cells, signaling, immune response, lymphocyte activation, cell surface receptors TCR, CD3, microdomains, immunologic synapse, T cell activation, TCR-CD3 complex, T lymphocytes, immune response, signaling pathways, cell surface receptors, lymphocyte activation, antigen recognition, immune synapse formation, molecular interactions, immunology, cell signaling, adaptive immunity TCR, CD3, microdomains, immunologic synapse, T cell activation, T lymphocytes, immune response, signaling pathways, cell signaling, molecular biology, immunology, T-cell receptor, CD3 complex, cellular immunology, adaptive immunity
1130	T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation. T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, suppression, immune regulation, cellular immunity, inflammatory diseases, autoimmune disorders T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, suppression, immune response, cell adhesion, integrins, immune regulation, autoimmune diseases, inflammation modulation T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, suppression, immune response, cellular immunology, autoimmunity, inflammatory diseases T regulatory cells, tTregs, αvβ8, suppressing, pathogenic T-cell responses, active inflammation, immune regulation, cell-mediated immunity, autoimmune diseases, inflammatory disorders T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, suppression, immunity, cellular interaction, autoimmune diseases, lymphocytes, immunology, therapeutic targets
380	Enhanced early production of inflammatory chemokines improves viral control in the lung. inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory infections, cytokine expression, antiviral defense inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory infection, cytokine storm, antiviral defense, acute lung injury inflammatory chemokines, viral control, lung, early production, enhanced response, immune system, respiratory viruses, cytokine storm, antiviral defense, infection management inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory infection, cytokine production, antiviral defense, airway inflammation inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory infection, cytokine storm, antiviral defense, pulmonary inflammation
1370	Vitamin D deficiency is unrelated to birth weight. Vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, nutrition vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, maternal, fetus, nutrition Vitamin D, deficiency, birth weight, unrelated, infants, pregnancy, nutrition, health, correlation, studies, research, medical, pediatric, endocrinology Vitamin D, deficiency, birth weight, pregnancy, neonatal, health, nutrition, correlation, infants, maternal Vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, nutrition
261	Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, exercise physiology, vascular biology Chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO mediation, cardiovascular health, exercise physiology, vascular biology chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, exercise physiology, vascular biology chronic aerobic exercise, endothelial function, vasodilation, NO, nitric oxide, cardiovascular health, exercise physiology, vascular biology chronic aerobic exercise, endothelial function, vasodilating mechanisms, nitric oxide, NO, cardiovascular health, exercise physiology, vascular biology
141	Auditory entrainment is strengthened when people see congruent visual and auditory information. auditory entrainment, visual information, auditory information, congruent stimuli, multisensory integration, brain synchronization, sensory processing, visual-auditory correlation, enhanced perception, neural entrainment auditory entrainment, visual information, auditory information, congruence, multisensory integration, sensory processing, neural synchronization, brain connectivity, perception, cognitive science auditory entrainment, visual-auditory integration, congruent stimuli, multisensory processing, sensory synchronization, perceptual binding, crossmodal effects, brain plasticity, neural synchronization, sensory enhancement auditory entrainment, visual information, congruent stimuli, sensory integration, multimodal perception, brain synchronization, neural entrainment, audio-visual integration, perception enhancement, cognitive neuroscience auditory entrainment, visual congruence, sensory integration, multimodal processing, audio-visual synchronization, perceptual enhancement, cross-modal interaction, neural synchronization, sensory coordination, enhanced perception
142	Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immune response, clinical outcomes, transplantation complications Autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, hematopoietic stem cell transplantation, immunosuppression, graft-versus-host disease, clinical outcomes, immune reconstitution autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immunosuppression, clinical outcomes, transplant complications autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher rate, infection risk, stem cell therapy, immunosuppression, clinical outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immune response, clinical outcomes, transplantation complications
384	Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings. Epidemiology, disease burden, noncommunicable diseases, low economic settings, prevalence, health disparities, socioeconomic factors, public health, global health, chronic diseases, low-income countries, poverty, healthcare access Epidemiology, Disease Burden, Noncommunicable Diseases, Low Economic Settings, Prevalence, Health Disparities, Global Health, Public Health, Chronic Diseases, Socioeconomic Factors epidemiology, disease burden, noncommunicable diseases, low economic settings, prevalence, public health, socioeconomic factors, health disparities epidemiology, disease burden, noncommunicable diseases, low economic settings, prevalence, health disparities, socioeconomic status, global health, public health, chronic diseases Epidemiological, disease, burden, noncommunicable, diseases, prevalence, low, economic, settings, health, disparities, global, health, low-income, countries, population, studies, risk, factors, prevention, control, public, health, policies
143	Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, clinical outcomes, transplantation complications, immune response modulation mesenchymal stem cells, autologous transplantation, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immune response, stem cell therapy, infection risk, interleukin-2 receptor, clinical outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunotherapy, clinical outcomes, infection risk, comparative study autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immune response, transplantation outcomes, infection risk, cytokine receptor antagonists autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, infection risk, clinical outcomes, comparative study
385	Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, epigenetics, tumor immunity, cancer therapy, immune modulation, molecular targeting, clinical translation Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immune modulation, cancer treatment, epigenetics, tumor microenvironment, immunotherapy, drug discovery Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, epigenetic therapy, tumor immunity, cancer treatment, immune modulation, epigenetics, oncology Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immune modulation, cancer treatment, epigenetic therapy, tumor microenvironment, immunotherapy, gene expression regulation Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, epigenetics, immune modulation, cancer therapy, tumor microenvironment, immunotherapy, gene expression regulation
386	Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations. errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations Errors, Peripheral, IV, Drug, Administration, Bolus, Multiple-step, Medicine, Preparations Errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations
1368	Vitamin D deficiency effects the term of delivery. Vitamin D, deficiency, pregnancy, delivery, term, gestation, health, maternal, fetal, outcomes Vitamin D, deficiency, pregnancy, term delivery, gestational outcomes, maternal health, fetal development Vitamin D, deficiency, pregnancy, term delivery, gestational outcomes, maternal health, prenatal nutrition, infant health, obstetrics, endocrinology Vitamin D, deficiency, pregnancy, delivery, term, health, outcomes, maternal, fetal, complications, nutrition, supplementation, research, studies, impacts, gestation, period, birth, premature, delay, medical, treatment, prevention, hormones, bone, density, immune, system, sunlight, exposure, diet, deficiency symptoms, risk, factors, public, health, awareness, education,Policy, guidelines, obstetrics, gynecology Vitamin D, deficiency, pregnancy, term delivery, prenatal health, maternal health, hormonal balance, childbirth, gestational period, nutrient deficiencies
146	Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immune response, transplantation medicine, clinical outcomes, immunosuppression autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, stem cell therapy, transplant rejection, therapeutic antibodies, clinical outcomes autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immune response, transplant rejection, immunosuppression, hematopoietic stem cells, clinical outcomes, transplant immunology autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, transplant rejection, biological therapy, clinical outcomes autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, transplant rejection, biological therapy, medical treatment options
388	Ethanol stress decreases the expression of IBP in bacteria. ethanol,stress,IBP,bacteria,gene expression,downregulation Decompounders,prokaryotes,alcohol toxicity,transcription levels ethanol, stress, IBP, expression, bacteria, decrease, inhibition, microbial, response, alcohol ethanol, stress, IBP, expression, bacteria, downregulation, molecular response, microbial adaptation ethanol, stress, expression, IBP, bacteria, downregulation, microbial, alcohol, inhibition, genes Ethanol,stress,IBP,bacteria,gene,expression,repression,prokaryotes,microorganisms,alcohol,tolerance,enzymes,molecular,biochemistry
268	Cold exposure increases BAT recruitment. cold exposure, brown adipose tissue, BAT recruitment, thermogenesis, cold-induced thermogenesis, adipose tissue adaptation, metabolic adaptation, cold acclimation, thermogenic capacity, energy expenditure cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold-induced thermogenesis, adipocyte browning, metabolic adaptation, cold acclimation, energy expenditure, obesity prevention cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold-induced thermogenesis, energy expenditure, obesity, metabolic rate, adaptive thermogenesis, human studies, animal models, physiological response, cold acclimation, fat metabolism, health benefits cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, metabolic adaptation, cold-induced thermogenesis, adipocyte browning, energy expenditure, cold acclimation, physiological adaptation cold exposure,BAT recruitment,thermogenesis,brown adipose tissue,heat production,winter adaptation,metabolic rate enhancement,cold-induced thermogenesis,energy expenditure increase,cold acclimation effects
1245	The one-child policy has been successful in lowering population growth. one-child policy, population growth, demographic control, family planning, birth rates, China population, reproductive policies, population management, fertility rates, overpopulation solutions one-child policy, population growth, success, China, demographic impact, family planning, birth rate, government policy one-child policy, population growth, successful, China, demographic control, birth rate, family planning, government policy, population management, reproductive control one-child policy, population growth, demographic control, birth rate reduction, family planning success, China population policy, reproductive control measures, fertility rate decline, population management effectiveness one-child policy, population growth, success, family planning, China, demographic control, birth rate, population management, governmental policy, fertility rate
148	Autophagy declines in aged organisms. autophagy, declines, aged, organisms, aging, cellular, degradation, lysosomes, metabolism, senescence autophagy, aging, aged organisms, cellular decline, senescence, lysosomal function, protein degradation, longevity, healthspan, molecular aging mechanisms Autophagy, aged, organisms, decline, aging, cellular processes, senescence, lysosomes, protein degradation, metabolic changes autophagy, aged, organisms, decline, aging, cellular, degradation, lysosome, health, senescence autophagy, aged, organisms, decline, aging, cellular, degradation, lysosomes, health, longevity
269	Cold exposure reduces BAT recruitment. cold exposure,BAT recruitment,thermogenesis,brown adipose tissue,temperature adaptation,energy expenditure,hypothermia,metabolic rate,preadipocyte differentiation,cold acclimation cold exposure,BAT recruitment,thermoregulation,brown adipose tissue,energy expenditure,hypothermia,metabolic rate,cold-induced thermogenesis cold exposure,BAT recruitment,thermogenesis,brown adipose tissue,metabolic rate,temperature regulation,hypothermia,energy expenditure,cold-induced thermogenesis,adipocyte differentiation cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold-induced thermogenesis, adipocyte recruitment, metabolic adaptation, cold acclimation, energy expenditure, fat activation cold exposure,BAT recruitment,brown adipose tissue,thermal regulation,metabolism,energy expenditure,hypothermia,thermogenesis
820	N-terminal cleavage increases success identifying transcription start sites. N-terminal, cleavage, success, identifying, transcription, start, sites N-terminal, cleavage, success, identifying, transcription, start, sites, bioinformatics, genomics, molecular, biology, protein, sequencing, gene, expression, analysis, improvement, methods, techniques N-terminal, cleavage, transcription, start, sites, identification, success, protein, genetics, biochemistry N-terminal cleavage, transcription start sites, protein identification, peptide analysis, proteomics, bioinformatics, gene expression, molecular biology, cleavage specificity, enzyme recognition, sequencing techniques, protein structure, functional genomics N-terminal, cleavage, transcription, start, sites, identification, success, protein, sequencing, bioinformatics
700	Localization of PIN1 in the Arabidopsis embryo does not require VPS9a Localization, PIN1, Arabidopsis, embryo, VPS9a, plant biology, molecular genetics, developmental biology, protein trafficking, vesicle transport, endocytosis, plant growth, gene expression, cellular signaling, mutant analysis, confocal microscopy, cellular localization, protein-protein interactions, plant development, auxin transport Localization, PIN1, Arabidopsis, embryo, VPS9a, protein, plant, development, trafficking, mutation, endocytosis, vesicle, polarity, auxin, signaling Localization, PIN1, Arabidopsis, embryo, VPS9a, protein trafficking, plant development, cell polarity, auxin transport, endocytosis regulators, vesicle transport, plant genetics, molecular biology, cell biology PIN1, Arabidopsis, embryo, VPS9a, localization, plant biology, developmental biology, cellular transport, protein localization, vesicle trafficking Localization, PIN1, Arabidopsis, embryo, VPS9a, protein, plant, development, genetics, molecular biology
821	N-terminal cleavage reduces success identifying transcription start sites. N-terminal,cleavage,transcription,start,sites,identification,reduction,success,protein,sequencing,bioinformatics,gene,expression,analysis,molecular,biology,biotechnology N-terminal, cleavage, transcription, start, sites, identification, reduction, success, protein, sequencing, bioinformatics, gene, expression, analysis N-terminal, cleavage, transcription, start, sites, identification, success, reduction, bioinformatics, molecular, biology, genomics, sequencing, RNA, protein, processing, enzymatic, degradation, signal, peptide, analysis, methods, techniques, research, study, experiment, results, implications, impact, improvement, strategies, optimization, challenges, approaches, science, technology, discovery, innovation, education, resources, tools, databases, software, algorithms, models, prediction, validation, accuracy, specificity, sensitivity, throughput, cost, efficiency, applications, fields, interdisciplinary, collaboration, trends, future, perspectives, reviews, articles N-terminal,cleavage,transcription,start,sites,identification,success,reduction,protein,sequencing,bioinformatics,gene,expression,analysis N-terminal,cleavage,transcription,start,sites,identification,protein,biochemistry,molecular,biology,genomics<tool_call>
702	Localization of PIN1 in the roots of Arabidopsis does not require VPS9a PIN1, Arabidopsis, roots, localization, VPS9a, protein trafficking, plant biology, cell biology, molecular biology, endocytosis, vesicle trafficking, auxin transport, developmental biology, plant roots, VPS proteins, Arabidopsis roots, PIN proteins, plant signaling, plant development, cellular processes, genetic factors, biological mechanisms, scientific research, plant science, biology research, genetics, molecular mechanisms, protein function, cellular localization, plant genetics, auxin, endomembrane system, plant physiology, gene expression, cellular transport, protein dynamics, cellular organization, plant cellular biology, cell signaling, Localization,PIN1,roots,Arabidopsis,VPS9a,requirement,plant,biology,molecular,genetics,cell,signaling,protein,traffic,development PIN1, Arabidopsis, roots, VPS9a, localization, plant biology, cell signaling, vesicle trafficking, auxin transport, developmental biology PIN1, Arabidopsis, roots, VPS9a, localization, plant biology, molecular genetics, proteomics, cellular transport, endocytosis Localization, PIN1, roots, Arabidopsis, VPS9a, protein trafficking, plant biology, cellular transport, genetic mutants, vesicle transport, plant roots, auxin transport, endocytosis, exocytosis, plant development, molecular biology, plant signaling, vesicle-mediated transport, cellular localization
823	N348I mutations cause resistance to zidovudine (AZT). N348I, mutations, resistance, zidovudine, AZT, HIV, antiretroviral, drug, treatment, therapy, viral, strain, genetic, variation, inhibition, enzyme, reverse, transcriptase N348I, mutations, resistance, zidovudine, AZT, HIV, treatment, retroviral, drug, resistance, mutation, enzyme, reverse, transcriptase N348I,mutations,resistance,zidovudine,AZT,HIV,antiretroviral,therapy,drug,resistance,mutation,site,directed,molecular,biology,virology,retrovirus,treatment,response,pharmaceutical,genetics N348I, mutations, resistance, zidovudine, AZT, HIV, antiretroviral, treatment, drug, therapy, genomic, variation, clinical, relevance, virology, medical, research, pharmacology, biochemical, mechanism, genetic, alteration, enzyme, reverse, transcriptase, viral, strain, isolated, study, findings, implications, healthcare, impact, patient, care, outcomes, efficacy, resistance, profiling, testing, methods, techniques, laboratory, analysis, biochemical, characterization, molecular, biology, genetics, infection, diseases, pathogens, microorganisms, review, article, N348I, mutations, resistance, zidovudine, AZT, HIV, antiretroviral, drug, therapy, treatment, virus, genetic, variant, strain, biochemical, mechanism, clinical, study, research, medicine, pharmacology
42	A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. microerythrocyte count, severe anemia, homozygous alpha thalassemia, thalassemia trait, hemoglobinopathy, red blood cell disorder, genetic blood disorder, alpha-globin gene, malaria resistance, hematological parameters, clinical manifestation, thalassemia carrier, hematocrit, hemoglobin concentration high microerythrocyte count, severe anemia, homozygous alpha thalassemia, alpha plus thalassemia, hemoglobin disorders, red blood cell morphology, genetic blood disorders, thalassemia trait, hematological parameters, clinical hematology microerythrocyte count, severe anemia, homozygous alpha thalassemia, alpha plus thalassemia, hematological disorder, red blood cell disorder, genetic blood disorder, thalassemia trait, hemoglobinopathy, clinical hematology, medical genetics, blood morphology, anemia vulnerability high microerythrocyte count, severe anemia, homozygous alpha plus thalassemia, thalassemia trait, red blood cell count, genetic blood disorders, hemoglobin levels, anemia risk factors, alpha thalassemia complications microerythrocyte count, severe anemia, homozygous alpha thalassemia, alpha plus thalassemia, hemoglobin disorder, red blood cell abnormality, genetic blood condition, anemia risk factors
48	A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. 1000, people, UK, asymptomatic, carriers, vCJD, infection vCJD, infection, asymptomatic carriers, UK, 1000 people UK, asymptomatic, carriers, vCJD, infection, people, total, 1000 vCJD, asymptomatic carriers, UK, infection, people, health, medical research, prion disease, neurological disorders, public health, epidemiology, disease carriers, variant Creutzfeldt-Jakob disease UK, asymptomatic, carriers, vCJD, infection, people, total, 1000
49	ADAR1 binds to Dicer to cleave pre-miRNA. ADAR1, Dicer, pre-miRNA, cleavage, binding, RNA editing, miRNA processing ADAR1, Dicer, pre-miRNA, cleavage, binding, RNA processing, microRNA, enzyme interaction, molecular biology, gene regulation ADAR1, Dicer, pre-miRNA, cleavage, binding, miRNA processing, RNA editing, protein interaction, molecular biology, gene regulation ADAR1,Dicer,pre-miRNA,binding,cleavage,microRNA processing ADAR1, Dicer, pre-miRNA, cleavage, binding, RNA processing, microRNA, enzyme interaction, RNA editing, molecular biology
1385	cSMAC formation enhances weak ligand signalling. cSMAC, formation, enhances, weak, ligand, signalling, cellular, immune, response, T-cell, activation, antigen, receptor, clustering, signaling, pathway, biochemistry, molecular, biology, immunology cSMAC, formation, enhances, weak, ligand, signalling, immunological, synapse, T-cell, activation, intracellular, signaling, pathways, molecular, mechanisms, protein, interactions, cell, biology, immune, response cSMAC, formation, enhances, weak, ligand, signalling, immunology, cell, biology, T-cell, receptor, signaling, pathway, activation, immune, response cSMAC, formation, enhances, weak, ligand, signalling, immune, response, T-cell, activation, antigen, receptor, signaling, pathway, molecular, mechanism cSMAC, formation, enhances, weak, ligand, signalling, cell, biology, immunology, T-cell, receptor, signaling, pathway, activation, immune, response, biochemistry, molecular, mechanism
1021	Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus. Rapid up-regulation, higher basal expression, interferon-induced genes, survival reduction, granule cell neurons, West Nile virus infection Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neuronal survival, viral infection, gene expression, interferon response, neurodegeneration, cytokine response, host defense, viral pathogenesis, brain infection Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, gene expression, neuronal survival, viral infection, interferon response Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neuronal survival, viral infection response, gene expression regulation, neurodegenerative processes, inflammation response, antiviral defense mechanisms Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neuronal response, viral infection, gene expression changes, neurotropic viruses, immune response, cell death, interferon signaling, neurological disorders, virus-host interaction
1020	Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus. Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus infection, neuronal protection, viral response, gene expression, neuroinflammation, antiviral mechanisms Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, infected, West Nile virus Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus infection, neuroprotection, viral response, gene expression modulation, neuronal resilience Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, infected, West Nile virus Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, infected, West Nile virus
1262	The repair of Cas9-induced double strand breaks in human DNA is error-prone. Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR, molecular biology, genetic modification, DNA repair mechanisms, cellular responses Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR-Cas9, DNA repair mechanisms, molecular biology, genetic engineering, NHEJ, HDR, mutation, biotechnology, gene therapy, genetic disorders, scientific research, cellular processes Cas9, double strand breaks, human DNA, repair, error-prone, CRISPR, genome editing, molecular biology, DNA repair mechanisms, cellular repair processes Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR-Cas9, DNA repair mechanisms, molecular biology, genetic engineering, biotechnology Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR, DNA repair mechanisms, molecular biology, genetic engineering, off-target effects
1140	Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer. α-tocopheryl acetate, prostate cancer, prevention, 400mg, vitamin E, antioxidant, health benefits, cancer prevention, dietary supplement, men's health α-tocopheryl acetate, prostate cancer, vitamin E, cancer prevention, antioxidants, health supplements, male health, nutritional supplements, prostate health, cancer risk reduction α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, antioxidant, health benefits, cancer risk reduction, dietary supplements, male health α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, antioxidant, health benefits, cancer risk reduction, nutritional supplement, clinical studies α-tocopheryl acetate, prostate cancer, vitamin E, cancer prevention, dosage 400mg, antioxidants, health supplements, male health, cancer research, therapeutic effects
1382	aPKCz causes tumour enhancement by affecting glutamine metabolism. aPKCz, tumour enhancement, glutamine metabolism, cancer, protein kinase C, cellular metabolism, oncology, tumorigenesis, metabolic pathways, glutamine dependence aPKCz, tumour, enhancement, glutamine, metabolism, cancer, signalling, enzyme, growth, proliferation, biochemical, pathway, disease, treatment, research, medical, biology, oncology aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolism alteration, oncogenesis, protein kinase C zeta, tumorigenesis, cellular metabolism, cancer biology aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolic pathways, oncology, cell signaling, tumor growth, biochemical processes, nutrition in cancer aPKCz, tumour enhancement, glutamine metabolism, cancer, oncology, metabolic pathways, cell signaling, protein kinases, tumor growth, glutamine dependency, metabolic reprogramming
274	Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy. nicotine replacement therapies, varenicline, bupropion, combination therapy, long-term abstinence, 52 weeks, smoking cessation, monotherapy, clinical outcomes, tobacco dependence nicotine replacement therapies, varenicline, bupropion, combination therapy, long-term abstinence, 52 weeks, smoking cessation, monotherapy, clinical outcomes, tobacco dependence treatment Combination, nicotine, replacement, therapies, varenicline, bupropion, long-term, abstinence, rates, 52, weeks, monotherapy nicotine replacement therapies, varenicline, bupropion, combination therapy, long-term abstinence, smoking cessation, 52 weeks, monotherapy, clinical trials, tobacco use disorder nicotine replacement therapies, varenicline, bupropion, combination therapy, long-term abstinence, 52 weeks, smoking cessation, monotherapy, clinical trials, tobacco use disorder
1019	Rapid phosphotransfer rates govern fidelity in two component systems Rapid phosphotransfer, rates, fidelity, two component systems, bacterial signaling, protein kinases, response regulators, microbial biochemistry, molecular biology, signal transduction Rapid phosphotransfer, rates, fidelity, two component systems, bacterial signaling, protein phosphorylation, regulatory mechanisms, microbial biochemistry Rapid phosphotransfer, rates, fidelity, two component systems, signal transduction, bacterial regulation, kinase activity, phosphorelay mechanisms Rapid phosphotransfer, rates, fidelity, two component systems, bacterial signaling, kinase activity, regulatory mechanisms, microbial processes, protein interactions, biochemical pathways Rapid phosphotransfer, fidelity, two component systems, bacterial signaling, protein kinases, response regulators, microbial communication, biochemical kinetics, signal transduction, enzymatic reactions, phosphorylation dynamics, molecular biology, cellular processes, genetic regulation, microbial physiology
275	Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, signaling pathways, clinical outcomes, drug synergy, mutation-specific treatments phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, oncology, drug synergy, molecular targeted therapy, cancer biology, signaling pathways, clinical oncology, pharmacology, tumor suppression, cancer research KRAS mutant tumors, phosphatidylinositide 3-kinase inhibitors, MEK 1/2 inhibitors, cancer treatment, combination therapy, tumor inhibition, signaling pathways, oncology research, clinical trials, drug synergy, targeted therapy phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, oncology, molecular targeting, drug synergism, tumor suppression phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant, tumors, treatment, combination therapy, cancer, targeted therapy, signaling pathways, oncology
1259	The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up. breast cancer, tamoxifen metabolism, genetic make-up, treatment outcome, patient capacity, medication response, genetic factors, pharmacogenomics, cancer treatment, hormonal therapy breast cancer, tamoxifen metabolism, treatment outcome, genetic makeup, patient response, pharmacogenetics, drug efficacy, genetic variation, cancer treatment, personalized medicine breast cancer, tamoxifen metabolism, treatment outcomes, genetic factors, patient genetics, pharmacogenomics, tamoxifen efficacy, genetic variation, metabolic capacity, personalized medicine breast cancer, tamoxifen metabolism, treatment outcome, genetic make-up, patient genetics, metabolic capacity, pharmacogenetics, breast oncology, genetic variation, drug response breast cancer, tamoxifen metabolism, treatment outcomes, genetic factors, patient genetics, pharmacogenomics, tamoxifen efficacy, genetic polymorphisms, cancer treatment, metabolic capacity
1137	TNFAIP3 is a tumor suppressor in glioblastoma. TNFAIP3, tumor suppressor, glioblastoma, cancer, gene expression, molecular biology, neurooncology, apoptosis, inflammation, therapeutic target TNFAIP3, tumor suppressor, glioblastoma, A20, cancer, neuro-oncology, molecular biology, gene expression, apoptosis, cell signaling TNFAIP3, tumor suppressor, glioblastoma, cancer genetics, gene expression, oncology, molecular biology, neurology, brain tumors, A20, NF-kappaB signaling, apoptosis, cell cycle regulation, therapeutic targets TNFAIP3, tumor suppressor, glioblastoma, cancer, neuro-oncology, A20, inflammation, apoptosis, cell death, genetic regulation, oncogenes, therapy target, biomarker TNFAIP3, tumor suppressor, glioblastoma, cancer, gene expression, oncology, neurology, molecular biology, A20, inflammation, apoptosis, cell cycle, therapy, prognosis, biomarker
1379	Women with a higher birth weight are more likely to develop breast cancer later in life. women, higher birth weight, breast cancer, later life, health risk, oncology, epidemiology, reproductive health women, higher birth weight, breast cancer, later life, risk factors, health outcomes, adult weight, cancer development, female health, prenatal factors women, higher birth weight, breast cancer, later life, risk factors, health outcomes, epidemiology, female, adult, medical research, cancer prevention, oncology, pregnancy outcomes, neonatal weight, long-term health effects women, higher birth weight, breast cancer, later life, risk factors, health outcomes, medical research, epidemiology, cancer prevention, public health, genetics, hormonal influences women, higher birth weight, breast cancer, development, later life, risk factors, health outcomes, epidemiology, oncology, reproductive health
399	Exposure to fine particulate air pollution is relate to anxiety prevalence. exposure, fine, particulate, air, pollution, anxiety, prevalence, health, environment, mental, illness, correlation, study, research, public, impact, respiratory, urban, rural, toxins, stress, psychological, effects, epidemiology, risk, factors, contamination, quality, index, control, measures, mitigation, strategies, intervention, policy, regulation, awareness, education, prevention, treatment, support, services, community, global, climate, change, sustainability, particulate, matter, pm2.5, environmental, impact, human, health, toxins, inhalation, respiratory, system, cardiovascular, diseases, Exposure, fine, particulate, air, pollution, anxiety, prevalence, health, environmental, factors, mental, illness, correlation, public, impact, studies, research, urban, areas, respiratory, effects exposure, fine, particulate, air, pollution, relate, anxiety, prevalence, health, environmental, impact, mental, public, studies, correlation, urban, rural, respiratory, effects, global, climate, change, policy, intervention, mitigation, strategies, research, findings, epidemiology, toxins, inhalation, stress, disorders, moods, cognitive, function, brain, inflammation, oxidative, stress, cellular, damage, toxins, immune, response, cardiovascular, system, pulmonary, disease, risk, factors, epidemiological, data, statistical, analysis, demographic, variations, socioeconomic, status, lifestyle, habits, exposure, fine particulate, air pollution, anxiety, prevalence, health impact, environmental factors, respiratory issues, mental health, public health, pollution sources, urban areas, particulate matter, PM2.5, psychological effects, long-term exposure, short-term exposure, risk factors, air quality, epidemiology, studies, research, correlation, stress, mood disorders, quality of life exposure, fine, particulate, air, pollution, relate, anxiety, prevalence, environmental, health, impact, mental, disorder, association, studies, research, findings, public, policy, mitigation, strategies
279	Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs. Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489
1014	Rapamycin decreases the concentration of triacylglycerols in fruit flies. rapamycin, triacylglycerols, fruit flies, concentration reduction, lipid metabolism, Drosophila melanogaster, pharmacological effect, biochemical pathway, aging research, metabolic regulation Rapamycin, triacylglycerols, fruit flies, concentration reduction, metabolic effect, lifespan extension, dietary restriction mimetic, TOR pathway inhibition rapamycin, triacylglycerols, fruit flies, concentration reduction, metabolic effect, lipid metabolism, drosophila melanogaster, pharmacological intervention, biochemical pathway, healthspan extension Rapamycin, triacylglycerols, fruit flies, concentration reduction, lipid metabolism, mTOR inhibition, Drosophila melanogaster, biochemical pathways, healthspan extension, dietary restriction mimetic Rapamycin, triacylglycerols, fruit flies, concentration reduction, metabolic effect, lifespan extension, dietary restriction mimic
830	NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases. NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, LATS1, LATS2, kinases, Hippo pathway NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, LATS1, LATS2, kinases, Hippo pathway NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, LATS1, LATS2, kinases, Hippo pathway
831	NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila. NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, prevention, signaling pathway, Hippo pathway, tumour suppression, cell proliferation, organ size control NF2, Merlin, phosphorylation, YAP, cytoplasmic, sequestration, Drosophila, tumor, suppressor, Hippo, pathway NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell growth, organ size regulation NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cellular growth, organism development NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila
1012	Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume. Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume Radioiodine,treatment,non-toxic,multinodular,goitre,thyroid,volume,reduction,thyroid,size,thyroid,nodule,thyroid,disease,radioactive,iodine,medical,therapy,endocrinology Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume
832	NFAT4 activation requires IP3R-mediated Ca2+ mobilization. NFAT4, IP3R, Ca2+ mobilization, activation, signaling pathway, cellular response, calcium signaling, ion channels, transcription factors, cellular calcium, pharmacology, molecular biology, cell signaling, biochemical processes NFAT4, IP3R, Ca2+, mobilization, activation, signaling, calcium, receptors, cellular, pathways NFAT4, activation, IP3R, Ca2+, mobilization, signaling, calcium, ion, intracellular, pathway, response, stimulation, cell, regulation, mechanism NFAT4, IP3R, Ca2+, mobilization, activation, signaling, calcium, ion, receptor, pathway NFAT4, IP3R, Ca2+, mobilization, activation, signaling, calcium, ion, receptor, pathway
834	NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates. NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, ROS, oxidative, stress, nitric, oxide, radicals, biochemistry, cellular, signaling NOX2-independent, pathways, generate, peroxynitrite, nitrogen, intermediates, reactive, nitric, oxide, superoxide, biology, biochemistry, oxidative, stress, inflammation NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reactive, nitrogen, species, oxidative, stress, biology, chemistry, molecular, mechanism, signaling, inflammation, neurodegeneration NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reaction, nitric, oxide, superoxide, reactive, oxygen, species, enzymatic, non-enzymatic, nitration, oxidative, stress, cellular, signaling, inflammation, disease, therapy, prevention NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reaction
956	Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling. GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, receptor signaling, effector coupling, cell signaling pathways, molecular biology, endocrinology, pharmacology GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, receptor signaling, cellular response mechanisms GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, signaling pathways, receptor activation, effector proteins, signal transduction, molecular mechanisms
50	AIRE is expressed in some skin tumors. AIRE, skin, tumors, expression, dermatology, oncology, biomarker, pathology, immunology, genetic-marker AIRE, skin, tumors, expression, dermatology, oncology, biomarker, pathology, medical, research, cancer, genetics, immunology AIRE, skin, tumors, expression, dermatology, oncology, immunology, cancer, gene, protein AIRE, skin, tumors, expression, dermatology, oncology, immunology, biomarker, cancer, medical-research AIRE, skin, tumors, expression, dermatology, oncology, biomarker, melanoma, carcinoma, immunology
715	Low expression of miR7a does represses target genes and exerts a biological function in ovaries. miR7a, low expression, represses, target genes, biological function, ovaries, gene regulation, miRNA, ovarian biology miR7a, low expression, represses, target genes, biological function, ovaries miR7a, low expression, represses, target genes, biological function, ovaries, gene regulation, microRNA, ovarian biology, gene expression modulation miR7a, low expression, represses, target genes, biological function, ovaries miR7a, low expression, represses, target genes, biological function, ovaries
957	Podocytes are motile and migrate in the presence of injury. podocytes,motility,migration,injury,kidney,renal,cells,response,repair,inflammation Podocytes,motility,migration,injury,kidney,disease,glomerulus,response,repair,cell,movement,renal,damage podocytes,motility,migration,injury,kidney,research,cells,biology,medical,health,glomerulus,damage,response,healing podocytes,motility,migration,injury,kidney,cells,response,repair podocytes,motile,migrate,injury,kidney,recovery,cell,movement,renal,repair
51	ALDH1 expression is associated with better breast cancer outcomes. ALDH1, expression, breast cancer, outcomes, prognosis, biomarker, cancer research, tumor marker, survival rate, clinical outcome ALDH1, breast cancer, outcomes, expression, prognosis, biomarker, survival, oncology, tumor, therapy, clinical trials, metastasis, chemotherapy, radiotherapy, immunotherapy, molecular markers, cancer research, gene expression, biological markers, medical oncology ALDH1, expression, breast cancer, outcomes, association, biomarker, prognosis, survival, oncology, tumor, malignancy, research, clinical, therapy, marker, genetic, cellular, biochemical ALDH1, breast cancer, expression, outcomes, prognosis, biomarker, tumor, survival, therapy, oncology ALDH1, breast cancer, expression, outcomes, prognosis, biomarker, tumor, survival, association, clinical significance
716	Low expression of miR7a exerts a biological function in testis. miR7a, low expression, biological function, testis, gene regulation, male fertility, RNA interference, microRNA, reproductive biology miR7a, low expression, biological function, testis, gene regulation, male fertility, RNA expression, microRNA, reproductive system, sperm development miR7a, low expression, biological function, testis, miRNA, gene regulation, reproductive biology, spermatogenesis, male fertility miR7a,testis,low expression,biological function,microRNA,expression levels,reproductive system miR7a, low expression, biological function, testis, microRNA, gene regulation, male reproduction, spermatogenesis, testicular function, RNA expression levels, molecular biology, reproductive health
837	NR5A2 is important in development of endometrial tissues. NR5A2, endometrial development, tissue formation, reproductive biology, hormonal regulation, gene expression, embryonic growth, uterine lining, cellular differentiation, molecular biology NR5A2, endometrial development, tissue formation, gene expression, hormonal regulation, cell differentiation, reproductive biology, molecular genetics, organogenesis, endometrium, transcription factors, developmental biology NR5A2, endometrial development, tissue development, endometrium, nuclear receptor, gene expression, embryonic development, reproductive biology NR5A2, endometrial development, tissue development, reproductive biology, gene function, endometrium, molecular biology, developmental biology NR5A2, endometrial development, tissue development, nuclear receptor, gene expression, reproductive biology
53	ALDH1 expression is associated with poorer prognosis in breast cancer. ALDH1, expression, breast cancer, prognosis, poorer outcomes, tumor markers, oncology, biomarkers, clinical research, cancer biology ALDH1, expression, poorer, prognosis, breast, cancer ALDH1, expression, breast cancer, prognosis, poorer outcome, biomarker, clinical significance ALDH1, breast cancer, prognosis, expression, poorer outcome, biomarker, cancer research, tumor biology, oncology, molecular markers ALDH1, expression, breast cancer, prognosis, poorer outcome, biomarker, oncology, tumor marker, clinical significance, gene expression, cancer research, molecular biology, medical genetics, therapeutic target, patient survival, cancer prognosis, molecular marker, cancer biology, oncogenic pathways
718	Low nucleosome occupancy correlates with low methylation levels across species. Low nucleosome occupancy, low methylation levels, species comparison, epigenetic regulation, chromatin structure, DNA methylation, nucleosome positioning, cross-species analysis, genomic correlates, epigenetics Low nucleosome occupancy, low methylation levels, species comparison, epigenetic regulation, chromatin structure, DNA methylation, nucleosome positioning, evolutionary biology, molecular genetics, gene expression regulation Low nucleosome occupancy, low methylation levels, species correlation, epigenetic marks, genomic regions, chromatin structure, DNA accessibility, regulatory elements, gene expression, evolutionary conservation Low nucleosome occupancy, low methylation levels, across species, epigenetic regulation, chromatin structure, DNA methylation, nucleosome positioning, comparative epigenomics, gene expression regulation, species-wide analysis low nucleosome occupancy, low methylation levels, species correlation, epigenetic markers, genomic regulation, DNA accessibility, chromatin structure, gene expression regulation, evolutionary conservation, bioinformatics analysis
839	Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles. Nanoparticles, targeted delivery, cell types, aptamers, lipid nanoparticles, specific targeting, drug delivery systems, biomolecular engineering, therapeutic applications, nanomedicine Nanoparticles, targeted delivery, specific cell types, aptamers, lipid nanoparticles, drug delivery systems, nanotechnology, biomedical applications, targeted therapy, molecular targeting Nanoparticles, Targeted Delivery, Cell Types, Aptamers, Lipid Nanoparticles, Specificity, Therapeutic Applications, Nanotechnology, Drug Delivery Systems, Biomolecular Engineering nanoparticles, targeted delivery, cell-specific, aptamers, lipid nanoparticles, drug delivery, molecular targeting, nanomedicine, therapeutic nanoparticles, biomolecular engineering nanoparticles, targeted delivery, cell-specific, aptamers, lipid nanoparticles, drug delivery, biomedical applications, nanotechnology, therapeutic targeting, RNA therapy
54	AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory, pulmonary, cytokines, signaling pathway AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory diseases, pulmonary fibrosis, kinase activation, inflammatory response AMPK, activation, inflammation, fibrosis, lungs, respiratory, protein kinase, signaling pathway, pulmonary, disease, therapy, molecular mechanism AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory system, pulmonary disease, biochemical pathways, cell signaling AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory system, pulmonary, disease, pathology
56	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, genetic factors, cellular models, neuronal dysfunction APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, Alzheimer's disease, neurodegeneration, gene expression, cellular model, neurological disorders APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, Alzheimer's disease, neurodegeneration, gene expression, cellular models, neurological disorders APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, protein expression, cellular models, Alzheimer's disease, neuronal health APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, genetic risk factors, neuronal expression, protein aggregation
57	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegenerative diseases, Alzheimer's disease, neuronal expression, protein production, neuron survival APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, genetic risk factors, neuronal expression, protein phosphorylation, cell-derived models, neurological disorders, brain research, molecular biology, neurobiology, tau protein, APOE gene, iPSC technology, neuronal cultures, synaptic function, neuronal survival, neuroprotective mechanisms, disease modeling, neurodegenerative diseases, amyloid beta, cerebral cortex, brain neurons, cellular neuroscience, protein expression, neuronal biology, neurological pathways, gene expression, neurochemical processes, pharmacological targets, therapeutic interventions APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, gene expression, cellular models, Alzheimer's disease, neuroprotective mechanisms APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, neuronal cells, protein phosphorylation, cell culture, neuroprotection APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, neuronal cells, brain research
1274	The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins. toxic type VI secretion system, T6SS, antibacterial effector, Escherichia coli, E. coli, inner tube, toxic effector proteins, bacterial defense mechanism, microbial competition, protein secretion T6SS, Escherichia coli, E. coli, toxic effector proteins, inner tube, antibacterial effector, tip structure, protein secretion system, bacterial toxins, gram-negative bacteria, microbial defense mechanisms T6SS, Escherichia coli, E. coli, toxic effector proteins, inner tube, antibacterial effector, type VI secretion system, tip structure, microbial defense, bacterial toxins T6SS, Escherichia coli, E. coli, toxic effector proteins, inner tube, antibacterial effector, secretion system, microbial toxins, bacterial effector proteins, T6SS effectors, T6SS toxins, E. coli T6SS, bacterial secretion systems, microbial pathogenesis, bacterial toxins, effector delivery, bacterial interactions, protein secretion, microbiology, bacterial virulence factors T6SS, Escherichia coli, E. coli, inner tube, toxic effector proteins, antibacterial effector, tip, secretion system, bacterial toxins, protein delivery, microbial warfare, pathogenic mechanisms
1395	p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). p16INK4A, accumulation, abnormal, wound, response, microinvasive, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, step, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, step, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, step, advanced, Oral, Potentially, Malignant, Lesions, OPMLs
1273	The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly. kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, microtubule dynamics, cell division, mitosis, meiosis, molecular motors kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, cell division, microtubule dynamics, mitosis, meiosis, molecular motors kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, microtubule dynamics, cell division, mitosis, molecular motors, spindle stabilization kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, microtubule dynamics, cell division, mitosis, molecular motors, spindle organization kinesin-8, Kip3, sliding activity, bipolar spindle assembly, mitosis, microtubules, protein function, cellular mechanics, molecular motors, spindle dynamics
1272	The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells. ON-bipolar cells, ERG b-wave, flash-evoked, retina, visual system, electroretinography, photoreceptor-bipolar cell synapse, neural response, light stimuli flash-evoked ERG, b-wave, ON-bipolar cells, retinal response, electroretinography, visual system, photoreceptor signaling ERG, b-wave, ON-bipolar cells, flash-evoked, retina, electroretinogram, visual system, photoreceptors, neural responses, visual neuroscience flash-evoked, ERG, b-wave, ON-bipolar, cells, retina, electroretinogram, photoreceptors, visual, neuroscience flash-evoked, ERG, b-wave, ON-bipolar, cells, activity, retina, electrophysiology, vision, neuroscience
1150	Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia Tetraspanin-3, acute myelogenous leukemia, causative factor, cancer development, leukemia research, myeloid neoplasms, protein function, hematopoietic disorders, molecular biology, oncology Tetraspanin-3, acute myelogenous leukemia, causative factor, leukemia development, myeloid leukemia, Tetraspanin role, cancer causation, hematologic malignancy, molecular mechanism, genetic factor Tetraspanin-3, acute myelogenous leukemia, AML, causative factor, cancer development, hematological malignancy, leukemia pathogenesis Tetraspanin-3, acute myelogenous leukemia, causative factor, leukemogenesis, myeloid malignancies, tetraspanin family, cancer development, hematopoietic disorders, oncogenic mechanisms, leukemia progression Tetraspanin-3, acute myelogenous leukemia, causative factor, leukemia development, Tet3, AML, blood cancer, hematopoietic disorders, oncology, molecular biology, cancer research, leukemia pathogenesis, genetic factors, protein function, medical genetics
1271	The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI. cardiac, amyloidosis, severity, transmurality, late, gadolinium, enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, late gadolinium enhancement, MRI, transmurality
1270	The risk of male prisoners harming themselves is ten times that of female prisoners. male prisoners, female prisoners, self-harm, risk factors, prison health, gender differences, incarceration, mental health, suicidal behavior, correctional facilities male prisoners, female prisoners, self-harm, risk, prison, gender differences, mental health, incarceration, suicide, violence male prisoners, female prisoners, self-harm, risk factors, prison population, gender differences, mental health, incarceration rates, suicidal behavior, correctional facilities male prisoners, female prisoners, self-harm, risk, prison, gender differences, inmate behavior, mental health, incarceration, suicide attempts male prisoners, female prisoners, self-harm, risk, prison, gender differences, mental health, suicide, incarceration, violence
163	Bariatric surgery has a positive impact on mental health. bariatric surgery, mental health, positive impact, weight loss surgery, psychological benefits, obesity treatment, improved mood, reduced depression, anxiety reduction, quality of life enhancement bariatric surgery, mental health, positive impact, weight loss surgery, psychological benefits, obesity treatment, improved quality of life, depression reduction, anxiety improvement, self-esteem enhancement bariatric surgery, mental health, positive impact, weight loss, psychological benefits, improved mood, reduced anxiety, enhanced quality of life bariatric surgery, mental health, positive impact, weight loss surgery, psychological benefits, obesity treatment, mood improvement, anxiety reduction, depression alleviation bariatric surgery, mental health, positive impact, weight loss, psychological benefits, obesity treatment, improved quality of life, depression reduction, anxiety improvement, self-esteem enhancement
1029	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes. Reduced responsiveness, interleukin-2, regulatory T cells, resistance, autoimmune diseases, Type 1 Diabetes interleukin-2, regulatory T cells, reduced responsiveness, autoimmune diseases, Type 1 Diabetes, resistance, immune response, cytokine signaling, T-cell function, autoimmunity Reduced responsiveness, interleukin-2, regulatory T cells, resistance, autoimmune diseases, Type 1 Diabetes interleukin-2, regulatory T cells, autoimmune diseases, Type 1 Diabetes, resistance, reduced responsiveness Reduced responsiveness, interleukin-2, regulatory T cells, resistance, autoimmune diseases, Type 1 Diabetes, immune tolerance, cytokine signaling, T cell function, autoimmunity, diabetes mellitus, immune regulation
960	Polymeal nutrition reduces cardiovascular mortality. Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, study, benefits, food, heart, research, risk, reduction, clinical, evidence, intervention, lifestyle,impact Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, study, benefits, research Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, heart disease, food, longevity polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, heart disease, study, research, benefits, food, medicinal meals, longevity, risk reduction Polymeal, nutrition, cardiovascular, mortality, health, diet, preventative, medicine, food, benefits, longevity, heart, disease, reduction, risk, factors, clinical, studies, evidence, lifestyle, changes
1389	mTORC2 regulates intracellular cysteine levels through xCT inhibition. mTORC2, cysteine, xCT, inhibition, regulation, intracellular, amino acids, redox balance, signaling pathway, cellular metabolism mTORC2, cysteine levels, xCT inhibition, intracellular regulation, metabolic pathway, amino acid transport, redox homeostasis, cell signaling, protein kinase, nutrient sensing mTORC2, cysteine, xCT, inhibition, regulation, intracellular, amino acids, signaling pathway, cellular metabolism, redox homeostasis mTORC2, cysteine, xCT, inhibition, regulation, intracellular, amino acids, signaling pathway, cellular metabolism mTORC2, cysteine, intracellular, xCT, inhibition, regulation, amino acid, signaling pathway, cellular metabolism, redox balance
1146	Teaching hospitals do not provide better care than non-teaching hospitals. teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, healthcare disparities, medical training, patient safety Teaching hospitals, non-teaching hospitals, healthcare quality, patient outcomes, medical education, hospital performance, clinical care, physician training, healthcare services, medical errors, patient satisfaction, health disparities teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, health services research teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, healthcare services, medical training, physician education teaching hospitals, non-teaching hospitals, healthcare quality, patient outcomes, medical education, hospital performance, comparative analysis, clinical care, medical training, healthcare delivery
1024	Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes. Recurrent mutations, CTCF anchor sites, oncogenes, genomic instability, cancer genetics, gene regulation, chromatin organization, mutation hotspots, DNA binding, transcription factors Recurrent mutations, CTCF anchor sites, oncogenes, genetic alterations, cancer biology, genomic instability, transcription factor binding sites, chromatin structure, regulatory regions, gene expression regulation Recurrent mutations,CTCF anchor sites,oncogenes,frequent mutations,genetic alterations,cancer biology,chromatin regulation,gene expression,transcription factors,genomic instability Recurrent mutations, CTCF anchor sites, oncogenes, genomic instability, cancer genomics, mutation frequency, adjacent genes, genetic alterations, tumor suppressors, chromatin insulators Recurrent mutations,CTCF anchor sites,oncogenes,frequent mutations,genomic alterations,cancer research,biological regulation,gene expression
1266	The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer. breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, maternal health, oncology, reproductive health breast cancer, parous women, placental weight, premenopausal, risk, pregnancy, association, health, oncology, reproductive factors breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, association, health outcomes, reproductive history, oncology, epidemiology breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, association, reproductive history breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, women's health, oncology, reproductive health
721	Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls. Lupus-prone mice, curliproducing bacteria, autoantibody titers, controls, infection, autoimmunity, murine lupus, bacterial infection, immune response, lupus model Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, control group, autoimmune response, mice study, bacterial infection, autoimmunity, lupus research Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, control group, lupus, autoimmunity, bacterial infection, immune response, antibodies Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, control group, autoimmune response, microbiota, immunology, disease model, inflammation Lupus, mice, curliproducing bacteria, autoantibody, titers, infection, control, autoimmune response, pathogenesis, experimental model
1144	Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India. Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, policy impact, health outcomes, beverage taxes, diabetes prevention, public health measures Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, policy impact, public health, dietary habits, beverage consumption, tax effectiveness Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, health policy, public health intervention, beverage tax, diabetes prevention, health outcomes, economic measures, non-communicable diseases Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, health policy, public health, economic measures, beverage tax, diabetes prevention, health outcomes, tax impact, non-communicable diseases, fiscal policies, health interventions Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, policy impact, health outcomes, beverage tax, diabetes prevention, public health intervention
723	Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions. Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cell signaling, leukocyte trafficking, inflammatory diseases, cellular organization, molecular biology, immunology Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, signaling pathways, inflammation regulation, raft-mediated signaling, neutrophil activation Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, raft regulation, leukocyte trafficking, inflammatory response, cell membrane dynamics Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, signaling pathways, inflammation regulation, leukocyte trafficking, immune cell migration Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cell signaling, inflammation regulation, neutrophil activation, membrane microdomains, immune cell trafficking
845	Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils. neutrophil extracellular traps, NETs, ANCA-stimulated, neutrophils, ANCA, autoimmune, inflammation, immune response, cellular defense, NETosis Neutrophil extracellular traps, NETs, ANCA, ANCA-stimulated, neutrophils, immune response, inflammation, autoimmune diseases Neutrophil extracellular traps, NETs, ANCA-stimulated, neutrophils, ANCA, immune response, inflammation, autoimmune diseases Neutrophil extracellular traps, NETs, ANCA-stimulated, neutrophils, ANCA, immune response, inflammatory process, neutrophil activation, NET formation, autoimmunity Neutrophil extracellular traps, NETs, ANCA, neutrophils, immune response, inflammation, autoimmunity, NETosis, microbial defense, vascular pathology
967	Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation. Arp2/3, CK-666, inhibitor, lamelliopodia, formation, pretreatment, cell, migration, cytoskeleton, actin, polymerization Arp2/3, CK-666, pretreatment, lamelliopodia, formation, inhibitor, cellular, microscopy, dynamics, cytoskeleton Arp2/3, CK-666, pretreatment, lamelliopodia, formation, inhibition, cell migration, actin polymerization, cytoskeleton, microfilaments Arp2/3, CK-666, pretreatment, lamelliopodia, formation, inhibition, cellular, motility, cytoskeleton, actin, polymerization, cell, migration, cancer, research, biology, microscopy, dynamic, imaging, treatment, drug, effect, study, experiment, science, biochemical, signaling, pathway Arp2/3, CK-666, lamelliopodia, formation, pretreatment, inhibitor, cell, migration, actin, polymerization
847	New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations. New drugs, tuberculosis, necrotic lesion, high concentrations, drug penetration, tuberculosis treatment, lesion targeting, pharmacokinetics, antimicrobial therapy new drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacology, medical research, antimicrobial agents New drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacokinetics, TB therapy, drug efficacy New drugs, tuberculosis, necrotic portion, lesion, high concentrations, drug penetration, treatment efficacy, pharmacokinetics, antimicrobial therapy, innovative treatments new drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacokinetics, drug delivery, medical research, infectious diseases, respiratory infections, mycobacterium tuberculosis, antibiotic resistance, therapeutic efficacy
727	Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts. Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, counterparts, comparison Ly6C hi monocytes, inflammatory capacity, Ly6C lo monocytes, comparison, immune response, monocytic subset, inflammation, cytokine production, innate immunity, blood cells, myeloid cells, immune cells, inflammatory diseases, cellular biology, immunology, research, medicine, biology Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, counterparts Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, counterparts, comparison, immune response, cytokine production, inflammation, cell biology, immune cells, blood cells, myeloid cells, macrophages, dendritic cells, innate immunity Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, inflammatory response, immune cells, monocyte subsets
728	Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes. Ly6C, monocytes, inflammatory, capacity, comparison, immunology, cytokines, activation, differentiation, macrophages, innate, immunity, blood, cells, mouse, human, inflammation, response, signaling, pathways, disease, therapy, research, biology, medicine Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune response, cytokine production, macrophage, differentiation, inflammation, immune cells, blood cells, leukocytes, innate immunity Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, differential, inflammation, immune, response, cells, hematopoietic, cytokines, tissue, resident, circulating, phenotype, function, polarization Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune response, cytokine production, inflammation, macrophages, cell differentiation, circulating monocytes, tissue infiltration, immune cells, innate immunity, blood cells, myeloid cells, inflammation regulation, immune system, monocytic lineage, cell activation, cytokine expression Ly6C hi, monocytes, inflammatory capacity, Ly6C lo, immune response, cytokine production, macrophages, differentiation, inflammation, immune cells, hematopoiesis, tissue repair, disease models, mouse models, human monocytes, circulating monocytes, tissue-resident monocytes, inflammatory diseases, atherosclerosis, diabetes, cancer, infection, immunity, inflammation markers, cytokine expression, gene expression, proteomics, cellular signaling, immune regulation, immunology, cellular biology, biomedical research, clinical implications
729	"Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway. lymphadenopathy,knockin mouse,SHP-2,MAPK pathway,genetic modification,immune response,mouse model,signaling pathway缺陷 Lymphadenopathy,knockin,mouse,SHP-2,MAPK,pathway,genetic,mutation,immunology,mouse,model狃 Note: The last character ""羁"" seems to be an encoding error and should be disregarded. Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, genetic model, immunodeficiency, signaling pathway, mouse model, protein deficiency, lymph node enlargement lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, deficiency, genetic model, immunology, signaling pathway, protein phosphatase, mouse model, lymph nodes, immune response, molecular biology, research, pathology lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, gene knockout, mouse model, immune system, protein signaling, lymph nodes, inflammation"
1163	The DdrB protein from Deinococcus radiodurans is an alternative SSB. DdrB, Deinococcus radiodurans, SSB, Single-strand binding protein, Alternative SSB, Radiation resistance, DNA repair, Bacterial proteins DdrB, Deinococcus radiodurans, alternative SSB, single-strand binding protein, radiation-resistant bacteria, DNA repair, genomic stability DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, DNA repair, radiation resistance, bacterial proteins, genomics, molecular biology, alternative SSB, genetic adaptation, extremophiles DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, alternative SSB, radiation resistance, DNA repair, bacterial proteins, molecular biology, genomics, proteomics, biochemistry, genetics, microbiology, extremophiles, stress response, DNA damage, genetic stability, cellular protection DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, alternative SSB, DNA repair, radiation resistance, bacterial proteins, molecular biology, genomics, proteomics
1041	Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes. histone H2A, H2A.Z, gene activation, yeasts, stabilizing, nucleosomes, +1 nucleosomes, chromatin, transcription, epigenetic regulation, DNA packaging, cellular biology, molecular genetics, histone variants, gene expression, cellular processes, biochemistry, molecular biology, genetics, yeast genetics, histone modifications, nucleosome dynamics, transcriptional regulation, chromatin structure, genetic research, yeast models, biological research, scientific studies, histone exchange, gene regulation, molecular mechanisms, cellular functions, genetic expression, biological systems, histone replacement, gene control, cellular genetics, chromatin remodeling histone H2A, H2A.Z, gene activation, yeasts, stabilizing, nucleosomes, +1 nucleosomes, chromatin, transcription, epigenetics histone, H2A, H2A.Z, gene, activation, yeasts, stabilizing, nucleosomes, +1, replacement, slows histone, H2A, H2A.Z, gene, activation, yeast, nucleosomes, replacement, stabilization, +1, chromatin, epigenetics, transcription, regulation histone, H2A, H2A.Z, gene, activation, yeast, nucleosome, +1, stabilization, chromatin, regulation, epigenetics
171	Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). Basophils, disease, development, patients, systemic lupus erythematosus, SLE, immunity, inflammation, autoimmune disorders, cellular response, immunomodulation Basophils, Disease, Development, Patients, Systemic, Lupus, Erythematosus, SLE, Counteract, Immunology, Inflammation, Autoimmune, Therapy, Mechanisms, Clinical, Research Basophils, counteract, disease, development, patients, systemic lupus erythematosus, SLE, immune response, inflammation, autoimmune disorder Basophils, counteract, disease, development, patients, systemic lupus erythematosus, SLE, immunology, inflammation, autoimmune disorders Basophils, disease development, systemic lupus erythematosus, SLE, counteract, immune response, inflammation, autoimmune diseases, hematopoietic cells, therapeutic targets
1282	Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence. Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Disease, Medical Treatment, Off-label Use Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Disease, Medical Therapy, Clinical Evidence, Off-Label Use, Dermatology Therapeutic, Dapsone, Pyoderma, Gangrenous, Anecdotal, Evidence, Treatment, Drug, Skin, Condition, Medical, Usage, Effectiveness, Reports Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Condition, Medical Therapy, Clinical Practice, Treatment Protocol, Medication Effectiveness Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Condition, Medical Therapy, Treatment Efficacy, Case Reports, Clinical Observations
1281	The ureABIEFGH gene cluster is induced by nickel (II) ion. ureABIEFGH, gene, cluster, induced, nickel, ion, Ni2+, metal, regulation, expression, bacteria, microbial, response, environmental, induction, genetic, mechanism, biochemistry, molecular, biology, nickel-dependent, operon, transcription, activation, stress, resistance, pathway, cellular, signaling, metal ions, coordination, transport, metabolism, homeostasis, proteomics, genomics, scientific, research, study, analysis, experiment, laboratory, technique, methodology, publication, article, journal, reference, academic, education, learning, understanding, knowledge, discovery, innovation, science, technology, environment ureABIEFGH, nickel, ion, gene, cluster, induction, metal, response, regulation, expression ureABIEFGH, gene, cluster, induced, nickel, ion, Nickel(II) ureABIEFGH, gene cluster, nickel (II) ion, induction, gene expression, metal ions, bacterial genes, regulation, nickel response ureABIEFGH, nickel, gene cluster, induction, ion, metal response, bacterial genes, nickel resistance, genetic regulation, microbial genetics
294	Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae. Crossover, hot, spots, gene, promoters, Saccharomyces, cerevisiae, genetics, yeast, recombination, DNA, biology, molecular, genetics, chromosomal, crossover, meiosis crossover, hot, spots, gene, promoters, Saccharomyces, cerevisiae, meiosis, recombination, yeast, genetics, biology, molecular, biochemistry, genomics Crossover, hot, spots, gene, promoters, Saccharomyces, cerevisiae, meiosis, recombination, genetics, yeast, biology, chromosomal, crossover, genomic, regions, exclusion, study, research, science, molecular, biochemistry, DNA, replication, transcription, cellular, mechanisms, genetic, mapping, chromatin, structure, function, regulation, expression, eukaryotes, model, organism, fungal, species, chromosome, behavior, interactions, evolutionary, significance, mutations, variants, analysis, techniques, methods, experiments, observations, data, interpretation, conclusions, publications, references, citations, Saccharomyces cerevisiae, gene promoters, crossover hot spots, recombination, yeast genetics, molecular biology, genetic mapping, meiosis, DNA crossover, chromosomal regions Crossover, hot, spots, gene, promoters, Saccharomyces, cerevisiae, meiosis, recombination, yeast, genetics, molecular, biology, DNA, repair, chromosomal, crossover, genetic, mapping, genomics, bioinformatics, eukaryotes, fungi
1280	The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG. ureABIEFGH, urease maturation proteins, UreD, UreH, UreE, UreF, UreG, gene cluster, protein encoding, urease biosynthesis, microbial enzymes, nitrogen metabolism ureABIEFGH, gene, cluster, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, bacterial, enzymology, protein, biosynthesis, nitrogen, metabolism, microbiology ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, bacterial, enzymes, ammonia, nitrogen, metabolism, catalysis, protein, assembly, structural, biochemistry, microbiology, genetics ureABIEFGH, urease maturation proteins, UreD, UreH, UreE, UreF, UreG, gene cluster, protein encoding
295	Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis. dendritic cells, innate lymphoid cells, crosstalk, intestinal homeostasis, immune regulation, gut immunity, mucosal immunity, cell communication, immune cells interaction, inflammation regulation dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, regulation, immune response, gut immunity, cell communication, mucosal immunity, ILCs, DCs, inflammation, lymphocytes, tissue homeostasis, adaptive immunity, innate immunity, signaling pathways, cytokines, immune regulation dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, immune regulation, gut immunity, cellular communication, mucosal immunity, inflammation, immune response dendritic cells, innate lymphoid cells, crosstalk, immune regulation, intestinal homeostasis, immune cells interaction, gut immunity, mucosal immunity dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, immune regulation, gut immunity, cellular interaction, mucosal immunity, inflammation control, tissue repair
298	Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis. cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondrial release, intermembrane release, cytosolic cytochrome c, apoptosis pathway, mitochondrial dysfunction cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondrial release, intracellular signaling, programmed cell death cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondria, protein release, caspase activation, intrinsic pathway cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondria, protein release, apoptotic pathway cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondrial release, protein translocation, apoptosis signaling, mitochondrial dysfunction
179	Birth-weight is positively associated with breast cancer. birth-weight, breast cancer, positive association, health risk, epidemiology, cancer research, maternal factors, neonatal health birth-weight, breast cancer, positive association, risk factor, epidemiology, health outcomes, oncology, maternal health, infant health, long-term health effects birth-weight, breast cancer, positive association, risk factor, epidemiology, health outcomes, women's health, oncology, biomedical research, public health, statistical correlation, medical studies, cancer research, body weight, neonatal health, long-term health effects, hormonal factors, disease susceptibility birth-weight, breast cancer, positive association, epidemiology, health outcomes, risk factors, clinical studies, oncology, public health, women's health birth-weight, breast cancer, positive association, epidemiology, health outcomes, oncology, maternal health, fetal development, risk factors, cancer research
971	Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, comparison, screening methods, cancer prevention, early detection, gynecological oncology, pap smear, HPV testing cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, cancer screening methods, HPV testing, cytology screening HPV, cervical cancer, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2 primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, HPV testing, cervical neoplasia, gynecological cancer screening, cytology sensitivity, HPV screening, cervical dysplasia detection, cervical lesion screening, cervical cancer prevention primary, cervical, cancer, screening, HPV, detection, longitudinal, sensitivity, conventional, cytology, cervical, intraepithelial, neoplasia, grade, 2
1279	The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events. cancer, patients, co-IR, blockade, adverse, autoimmune, events, treatment, immunotherapy, side-effects, health, medicine, oncology, autoimmunity cancer, co-IR, blockade, treatment, adverse, autoimmune, events cancer, patients, co-IR, blockade, adverse, autoimmune, events, treatment, precipitates cancer, patients, co-IR, blockade, treatment, adverse, autoimmune, events cancer, co-IR, blockade, treatment, adverse, autoimmune, events, patients
1278	The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events. cancer, patients, co-IR, blockade, adverse, autoimmune, events, treatment, safety, immunotherapy cancer treatment, co-IR blockade, adverse events, autoimmune response, patient safety, immunotherapy, clinical trials, side effects, oncology, immune checkpoint inhibitors cancer treatment, co-IR blockade, adverse autoimmune events, immune checkpoint inhibitors, oncology, clinical trials, patient outcomes, safety profile, immunotherapy, autoimmune disorders cancer treatment, co-IR blockade, adverse autoimmune events, cancer patients, immunotherapy, safety, clinical outcomes, autoimmune response cancer treatment, co-IR blockade, adverse events, autoimmune response, patient safety, immunotherapy, clinical trials, oncology, immune checkpoint inhibitors
852	Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment. Non-invasive ventilation, inadequate response, conventional treatment, respiratory therapy, clinical guidelines, patient management, ventilation strategies, medical intervention, treatment efficacy, respiratory care non-invasive ventilation, inadequate response, conventional treatment, decreased use, respiratory therapy, clinical guidelines, patient management, treatment efficacy, ventilation strategies, medical intervention Non-invasive ventilation, inadequate response, conventional treatment, decrease usage, respiratory therapy, clinical guidelines, patient monitoring, treatment efficacy, medical intervention, respiratory failure management Non-invasive ventilation, inadequate response, conventional treatment, decreased use, respiratory therapy, clinical guidelines, patient management, ventilation strategies, medical intervention, treatment efficacy non-invasive ventilation, inadequate response, conventional treatment, decrease usage, respiratory therapy, clinical guidelines, patient outcomes, ventilatory support, medical intervention, treatment efficacy
975	Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators. Primary, pro-inflammatory, cytokines, induce, secondary, pro-inflammatory, anti-inflammatory, mediators, inflammation, immune, response, cytokine, signaling, modulation, interleukins, tumor, necrosis, factor, interferons, chemokines, cytokine, network, regulation, inflammatory, cascade, cytokine, storm, immune, cells, activation, signaling, pathways, inflammatory, diseases, treatment, therapy, research, medical, biology, immunology, cellular, signaling, molecular, mechanisms primary cytokines, pro-inflammatory cytokines, secondary mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, immune response, cytokine signaling, inflammation regulation, cytokine-mediated signaling Primary cytokines, pro-inflammatory cytokines, secondary mediators, pro-inflammatory mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, immune response, cytokine signaling, inflammation regulation primary cytokines, pro-inflammatory, secondary mediators, anti-inflammatory, cytokine induction, inflammatory response, mediator induction, cytokine-mediated signaling primary cytokines, pro-inflammatory cytokines, secondary mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, mediators regulation, immune response, inflammatory signaling
613	Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits. microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, cellular repair, motor function, molecular biology, neurological disorders microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, motor function, cellular repair, protein modification, axonal transport microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, cellular repair mechanisms, motor function improvement, genetic mutation effects, acetylation therapy microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurological repair, Parkinson's disease, cellular dysfunction, protein modification, motor function, neurodegenerative disorders microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, motor function, protein modification, therapeutic intervention, cellular repair mechanisms
70	Activation of PPM1D suppresses p53 function. PPM1D, p53, activation, suppression, function, oncogene, tumor, protein, phosphatase, cell, cycle, DNA, damage, response, cancer, therapy, signaling, pathway PPM1D, p53, activation, suppression, function, tumor, protein, signaling, pathway, cancer, cell, cycle, apoptosis, DNA, damage, response, oncogene, phosphatase PPM1D, p53, activation, suppresses, function, protein phosphatase, MDM4, tumor suppressor, oncogene, cell cycle, apoptosis, cancer, signal transduction, phosphorylation, dephosphorylation, genetic regulation, molecular biology, biochemistry PPM1D, p53, activation, suppression, function, protein, cell cycle, DNA damage response, oncogene, tumor suppressor PPM1D, p53, activation, suppression, function, cell signaling, tumor suppressor, protein phosphatase, oncogenesis
72	Activator-inhibitor pairs are provided dorsally by Admpchordin. Activator-inhibitor, pairs, dorsally, Admp, chordin, developmental, biology, signaling, morphogenesis, embryology Activator-inhibitor, pairs, dorsally, Admp, chordin, development, patterning, signaling, bmp, embryology Activator-inhibitor, pairs, dorsally, Admp, chordin, developmental, biology, signaling, molecules, pattern, formation, embryology Activator-inhibitor pairs, dorsally, Admp, chordin, developmental biology, morphogenesis, signaling pathways, dorsal-ventral axis, embryo development, gene expression, protein interactions, molecular biology activator-inhibitor, pairs, dorsal, Admp, chordin, embryonic, development, signaling, patterning, axis, regulation, morphogenesis, BMP, TGF-beta, pathway
859	Normal expression of RUNX1 has tumor-promoting effects. RUNX1, tumor-promoting, gene expression, cancer, oncogene, transcription factor, hematopoiesis, leukemia, cell proliferation, apoptosis regulation RUNX1, tumor-promoting, gene expression, oncogene, leukemia, cancer biology, transcription factor, cell proliferation, molecular biology, medical genetics RUNX1, tumor-promoting, normal-expression, gene-expression, cancer, oncogene, leukemia, transcription-factor, cellular-growth, molecular-biology, medical-research, genetics, carcinoma, neoplasms, hematopoiesis, protein-function, cell-proliferation, biomarker, therapeutic-target, disease-mechanisms RUNX1, tumor-promoting, normal-expression, oncogene, leukemia, cancer-biology, gene-regulation, hematopoiesis, transcription-factor, cell-proliferation RUNX1, tumor-promoting, gene expression, oncogenesis, cancer, molecular biology, transcription factor, cellular pathology
619	Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments. vessel density, fibrosis reduction, chemotherapy efficacy, treatment outcomes, angiogenesis, tumor microenvironment, cancer therapy, medical oncology, clinical oncology, tumor biology vessel density, fibrosis reduction, chemotherapy efficacy, treatment outcomes, tumor microenvironment increased vessel density, reduction fibrosis, chemotherapy efficacy, angiogenesis, tumor microenvironment, cancer treatment, vascular normalization, fibrotic response, drug delivery, oncology Increased vessel density, reduction in fibrosis, chemotherapy efficacy, treatment outcomes, angiogenesis, tumor microenvironment, cancer therapy, medical oncology, vascular density, fibrosis reduction, oncological treatments, therapy resistance vessel density, fibrosis reduction, chemotherapy efficacy, vascularization, tumor microenvironment, treatment resistance, oncology, medical research, cancer therapy, drug delivery obstacles
75	Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. Active, H. pylori, urease, polymeric, structure, subunits, UreA, UreB H. pylori, urease, polymeric structure, subunits, UreA, UreB, active enzyme, protein structure, bacterial enzyme, urease subunits H. pylori, urease, polymeric structure, UreA, UreB, active enzyme, protein subunits, microbial enzymes H. pylori, urease, polymeric structure, UreA, UreB, protein subunits, enzyme structure, microbial enzymes H. pylori, urease, polymeric structure, UreA, UreB, active enzyme, subunits
1175	The PPR MDA5 has two N-terminal CARD domains. PPR, MDA5, N-terminal, CARD, domains, innate, immunity, RNA, sensing, protein, structure, signaling, pathogen, recognition, receptor PPR, MDA5, N-terminal, CARD, domains, immune, signaling, pathogen, recognition, protein, structure, function PPR, MDA5, N-terminal, CARD, domains, innate, immunity, RNA, sensing, molecular, biology, protein, structure, signaling, pathway PPR,Mda5,N-terminal,CARD,domain/mol,innate-immunity,viral-detection,receptor/protein PPR, MDA5, N-terminal, CARD, domains, innate, immunity, RNA, sensing, virus, recognition, signaling, pathogen, detection, cellular, defense, mechanism
180	Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking, increased, neurodegeneration, mitochondria, cellular dysfunction TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction
183	Bone marrow cells contribute to adult macrophage compartments. bone marrow, cells, adult, macrophage, compartments, immune system, hematopoiesis, tissue resident macrophages, circulation, differentiation, monocytes bone marrow, cells, contribute, adult, macrophage, compartments, hematopoiesis, immune system, tissue resident, monocytes, differentiation, circulation, organs, inflammation, disease, repair, regeneration bone marrow cells, macrophage compartments, adult macrophages, hematopoiesis, immune system, cell differentiation, tissue resident macrophages, circulation, progenitor cells, myeloid cells bone marrow, cells, contribute, adult, macrophage, compartments, hematopoiesis, immune system, tissue-resident macrophages, monocytes, differentiation, lineage, organ-specific macrophages bone marrow cells, adult macrophages, hematopoiesis, immune system, tissue resident macrophages, monocytes, differentiation, cellular contribution, adult organisms, biological processes
1292	There is no association between HNF4A mutations and diabetes risks. HNF4A, mutations, diabetes, risks, association, genetic, study, research,medical, health, endocrinology HNF4A, mutations, diabetes, risks, genetic, association, study, research, health, endocrinology HNF4A, mutations, diabetes, risks, association, genetic, study, research, health, medical, endocrinology, molecular, biology, genetics HNF4A, mutations, diabetes, risks, association, genetic, health, study, research, no-link HNF4A, mutations, diabetes, risks, association, genetic, study, research, health, endocrinology
185	Breast cancer development is determined exclusively by genetic factors. Breast cancer, genetic factors, hereditary, genomics, oncogenes, tumor suppressor genes, BRCA1, BRCA2, genetic predisposition, cancer genetics, molecular biology, breast pathology breast cancer, genetic factors, development, exclusivity, heredity, genetics, oncology, tumor biology genetic factors, breast cancer, development, exclusively, hereditary, mutation, genetics, oncogenes, tumor suppressor genes, familial cancer syndromes Breast cancer, genetic factors, hereditary, oncogenes, tumor suppressor genes, BRCA1, BRCA2, genetic predisposition, cancer genetics, molecular biology, cancer development, non-genetic factors, environmental influences genetic factors, breast cancer, development, hereditary, genetics, oncology, mutations, familial risk, predisposition, genetic predisposition
1290	There is an inverse relationship between hip fractures and statin use. hip fractures, statin use, inverse relationship, bone health, cholesterol medication, osteoporosis, fracture risk, cardiovascular drugs hip fractures, statin use, inverse relationship, statins, osteoporosis, bone health, cholesterol lowering drugs, fracture risk hip fractures, statin use, inverse relationship, elderly health, bone health, cardiovascular drugs, fall prevention, osteoporosis treatment, pharmacology, medical research hip fractures, statin use, inverse relationship, statins, osteoporosis, bone health, cholesterol-lowering drugs, elderly care, pharmacology, medical research hip fractures, statin use, inverse relationship, osteoporosis, cardiovascular drugs, bone health, cholesterol lowering drugs, fracture risk, medical studies, pharmacology
1049	Ribosomopathies have a low degree of cell and tissue specific pathology. ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, molecular-genetics, cellular-dysfunction, tissue-damage, genetic-disorders, ribosomal-proteins Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, genetic-disorders, cellular-impact, tissue-impact, medical-research, genetic-research ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, cellular-effects, tissue-effects, disease-mechanisms, genetic-disorders, molecular-biology Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, genetic-disorders, cellular-impact, tissue-impact, biological-processes, medical-research, rare-diseases Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, cellular, tissue, disease-manifestation, genetic-disorders, ribosomal-proteins, molecular-basis, pathology-mechanisms
982	Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body. Proteins, synthesized, growth, cone, ubiquitinated, higher, rate, cell, body Proteins, growth cone, ubiquitination, cell body, synthesis, rate, neural development, axon guidance, molecular biology, neuroscience Proteins, synthesized, growth, cone, ubiquitinated, higher, rate, cell, body Proteins, growth cone, ubiquitination, cell body, synthesis rate, neural development, protein degradation, neuronal plasticity, axon guidance, molecular biology, neuroscience, cellular biochemistry proteins, synthesized, growth cone, ubiquitinated, cell body, rate, differential modification, neural development, axonal transport, protein turnover
742	Macrolides have no protective effect against myocardial infarction. Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, clinical trials, pharmacology, medicine Macrolides, myocardial infarction, protective effect, antibiotics, heart disease, cardiovascular outcomes, clinical trials, medication efficacy Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, pharmacology, clinical trials, risk factors, medication safety, heart attack prevention macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, clinical trials, pharmacology, therapeutic outcomes Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, clinical trials, drug efficacy
501	Headaches are not correlated with cognitive impairment. headaches, cognitive impairment, correlation, neurological disorders, brain health, pain management, mental function, clinical studies, symptom analysis, health research headaches, cognitive impairment, correlation, neurological disorders, brain function, pain management, mental health, clinical studies, symptoms, treatment headaches, cognitive impairment, correlation, neurological disorders, brain function, pain management, health research, medical studies, symptom analysis, mental health headaches, cognitive impairment, correlation, neurological disorders, pain management, brain function, health research, medical studies, symptom analysis, non-related conditions headaches, cognitive impairment, correlation, neurological disorders, brain function, pain management, health research, medical studies, symptom analysis, clinical outcomes
743	Macrolides protect against myocardial infarction. macrolides, myocardial infarction, protection, cardiac health, antibiotics, heart disease, anti-inflammatory, atherosclerosis, cardiovascular protection, bacterial infection treatment Macrolides, myocardial infarction, cardiac protection, antibiotics, heart disease, anti-inflammatory, lipid metabolism Macrolides, myocardial, infarction, protection, antibiotics, cardiovascular, risk, prevention, therapy, treatment Macrolides, myocardial infarction, cardiac protection, antibiotics, heart disease, anti-inflammatory effects, cardiovascular benefits Macrolides, myocardial infarction, cardiac protection, antibiotics, heart disease, cardiovascular health, clinical trials, pharmacology, anti-inflammatory, bacterial infection prevention
985	Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy. Pseudogene, PTENP1, PTEN, miRNA, decoy, regulation, expression Pseudogene, PTENP1, PTEN, miRNA, decoy, gene-regulation, expression-regulation, molecular-biology, non-coding-RNA, cancer-biology Pseudogene, PTENP1, PTEN, expression, regulation, miRNA, decoy, cancer, gene, biology, molecular, mechanism, RNA, genetics, cellular, pathway, tumor, suppressor, oncogene Pseudogene, PTENP1, PTEN, miRNA, decoy, regulation, expression, non-coding, RNA, cancer, genetics, molecular, biology, gene, therapy, biomarker Pseudogene, PTENP1, PTEN, miRNA, decoy, regulation, expression, gene, molecular, biology, cancer, therapy, genetics, RNA, interference, cellular, pathway, biomarker, health, science, research
502	Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements. Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement, patient, flow, staff, training, communication, technology, infrastructure, management, optimization healthcare delivery, efficiency, crowded centers, structural improvements, logistical enhancements, interpersonal communication, patient care, healthcare systems, service delivery, operational management Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement, impairment Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, improvement, elements
623	Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis. vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological diseases, health implications, nutritional deficiencies vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, immune system, health outcomes, nutritional deficiencies vitamin D, serum concentrations, multiple sclerosis, risk factors, nutritional deficiencies, autoimmune diseases, neurological disorders vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, immune system, nutrition, health outcomes, epidemiology, clinical studies vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, nutritional deficiencies, autoimmune diseases
744	Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein. Macropinocytosis, amino acids, protein uptake, intracellular uptake, cell supply, nutrient acquisition, cellular nutrition, endocytosis, vesicle formation, lysosomal degradation, metabolic pathways, cancer metabolism, cell biology, molecular biology, biochemistry Macropinocytosis, amino acids, intracellular uptake, protein supply, cell nutrition, endocytosis, nutrient acquisition, cellular metabolism Macropinocytosis, amino acids, intracellular uptake, protein supply, cell nutrition, endocytosis, nutrient acquisition, cellular metabolism Macropinocytosis, amino acids, protein uptake, intracellular, cell supply, nutrient acquisition, endocytosis, cellular nutrition, lysosomal degradation, extracellular proteins Macropinocytosis, amino acids, intracellular uptake, protein supply, cell nutrition, cellular metabolism, endocytosis, nutrient acquisition
507	Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication. Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation
628	Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin. Human T-cell lymphotropic virus type 1, HTLV-1, African origin, infection frequency, viral infection, T-cell infection, epidemiology, ethnic predisposition African origin, human T-cell lymphotropic virus type 1, infection frequency, HTLV-1, epidemiology, virology, population studies, genetic predisposition Human T-cell lymphotropic virus type 1, HTLV-1, infection, African origin, prevalence, retrovirus, lymphotropic, T-cell, epidemiology, virus transmission, genetic factors, geographic distribution African origin, human T-cell lymphotropic virus type 1, HTLV-1, infection frequency, ethnic predisposition, viral infection, human lymphotropic virus Human T-cell lymphotropic virus type 1, HTLV-1, African origin, infection frequency, viral prevalence, ethnic predisposition, African ethnicity, lymphotropic viral infection
508	Hematopoietic Stem Cell purification reaches purity rate of up to 50%. Hematopoietic, Stem, Cell, purification, purity, rate, 50% Hematopoietic, Stem, Cell, purification, purity, rate, 50% Hematopoietic, Stem, Cell, purification, purity, rate, 50% Hematopoietic Stem Cell, purification, purity rate, 50% Hematopoietic Stem Cell, purification, purity rate, 50%
1187	The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription. YAP1, TEAD, transcription, nucleus, translocation, gene, modulation, DNA-binding, proteins, complex, interaction, target, factors YAP1, TEAD, nuclear translocation, transcription factors, DNA-binding proteins, target gene transcription, gene regulation, cellular signaling, oncogenesis, Hippo pathway YAP1, TEAD, nuclear translocation, transcription factors, DNA-binding proteins, target gene transcription, gene expression regulation, cellular signaling pathways, protein-protein interactions, nuclear import, chromatin remodeling, transcriptional activation, oncogenic processes, tissue homeostasis, developmental biology YAP1, TEAD, nucleus, transcription factors, DNA-binding proteins, target gene transcription, translocates, modulate YAP1, TEAD, nuclear translocation, transcription factors, DNA-binding proteins, gene transcription modulation
1185	The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. US health care system, cost savings, kidney transplants, patients, kidney paired donation, optimized program, national program, medical economics, transplant waitlist, health policy US health care system, cost savings, kidney transplants, patients, kidney paired donation, optimized program, national program, transplant efficiency, medical economics, health policy, organ donation, patient outcomes, healthcare reform, transplant waitlist, medical innovation US health care system, cost savings, kidney transplants, patients, optimized national kidney paired donation program, 750 million, 7% participation US health care system, cost savings, kidney transplants, patients, kidney paired donation, optimized program, national program, medical economics, transplant waiting list, health policy, organ donation, medical treatment, healthcare efficiency, transplant surgery, patient care, health insurance, medical research, health statistics, public health, healthcare reform US health care system, kidney transplants, patients, kidney paired donation program, cost savings, optimized program, healthcare costs, organ donation, medical economics, patient waitlists, transplantation efficiency
1062	S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases. S-nitrosylated GAPDH, histone deacetylases, transnitrosylation, physiological process, protein modification, nitric oxide signaling, epigenetic regulation, enzymatic activity, cellular function, post-translational modification S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, physiological, nitric, oxide, post-translational, modification, protein, interaction, enzymatic, activity, cellular, function, signaling, pathway S-nitrosylated,GAPDH,transnitrosylates,histone,deacetylases,physiological,function,Nitric,Oxidative,Stress,Post-translational,Modifications,Enzyme,Activity,Cell,Signaling S-nitrosylated,GAPDH,transnitrosylation,histone,deacetylases,physiological,Nitric,Oxidation,Protein,Post-translational,Modification S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, physiological, nitrosylation, protein, modification, enzymatic, activity
1180	The PRR MDA5 is a sensor of RNA virus infection. PRR MDA5, RNA virus, infection sensor, viral infection detection, immune response activation, pathogen recognition receptor PRR, MDA5, RNA, virus, infection, sensor, immunity, detection, pathogen, viral, innate, immune, response, signaling, recognition PRR, MDA5, RNA, virus, infection, sensor, detection, immune, response, pathogen, recognition, receptor, antiviral, defense PRR, MDA5, RNA, virus, infection, sensor, detection, innate, immunity, pathogen, recognition, receptor PRR, MDA5, RNA, virus, infection, sensor, detection, immune, response, signaling, pathway
198	CCL19 is absent within dLNs. CCL19, dLNs, absence, lymph nodes, chemokine, immune response, tissue distribution, molecular biology, immunology CCL19, dLNs, absence, lymph nodes, chemokine, immune response CCL19, dLNs, absent, lymph nodes, chemokine, CCL19 expression, dendritic cells, lymph node environment, immune response, cell migration CCL19, dLNs, absent, lymph nodes, chemokine, CCL19 deficiency, lymph node microenvironment, immune cell trafficking CCL19, dLNs, absence, lymph nodes, chemokine, immune response, tissue distribution, lymph node microenvironment
870	Obesity decreases life quality. obesity, life quality, health impact, well-being, mortality risk, chronic diseases, mental health, physical health, lifestyle factors, weight management obesity, life quality, health impact, well-being, lifestyle diseases, reduced mobility, mental health, chronic conditions obesity, life quality, decreases, health impact, wellbeing, longevity, chronic diseases, mental health, physical health, lifestyle factors obesity, life quality, health impact, well-being, lifestyle diseases, overweight, public health, longevity, mental health, physical health Obesity, Life Quality, Health Impact, Well-being, Chronic Diseases, Weight Management, Lifestyle Changes, Nutrition, Physical Activity, Mental Health
993	Pyridostatin destabilizes the G - quadruplex in the telomeric region. Pyridostatin, G-quadruplex, telomeric, destabilizes, DNA, telomeres, molecular biology, biochemical mechanism, cancer research, nucleic acids, drug interaction, quadruplex stabilization, cellular aging, genetic instability Pyridostatin, G-quadruplex, telomeric region, destabilization, DNA structure, telomeres, quadruplex destabilizer, biochemical mechanism, molecular biology, cancer research Pyridostatin, G-quadruplex, telomeric, destabilizes, telomere, DNA, molecular biology, biochemistry, cancer research, telomere instability Pyridostatin, G-quadruplex, telomeric, destabilizes, DNA, telomeres, biochemistry, molecular-biology Pyridostatin, G-quadruplex, telomeric, destabilization, telomeres, DNA structure, molecular biology, cancer research, gene regulation, biophysical chemistry
873	Obesity is determined solely by environmental factors. obesity, environmental factors, genetics, diet, physical activity, socioeconomic status, lifestyle, public health, nutrition, obesity causes obesity, environmental factors, genetic influences, lifestyle choices, dietary habits, physical activity, socioeconomic status, cultural factors, obesity determinants, health policies Obesity, environmental factors, genetics, lifestyle, diet, physical activity, socioeconomic status, urbanization, food availability, cultural influences Obesity, environmental factors, genetic predisposition, lifestyle choices, dietary habits, physical activity, socioeconomic status, urbanization, access to healthy food, sedentary behavior Obesity, environmental factors, diet, physical activity, socioeconomic status, urbanization, food availability, lifestyle, genetic predisposition, health policies, public health interventions, sedentary behavior, nutrition education, cultural practices, obesity prevalence, environmental influences, health outcomes, metabolic disorders, obesity prevention, obesity treatment
1179	The PRR MDA5 has a central DExD/H RNA helices domain. PRR MDA5, central domain, DExD/H RNA helicase, protein structure, RNA binding, helicase activity PRR MDA5, central domain, DExD/H, RNA helices, protein structure, molecular biology, helicase domain, PRR family, MDA5 function, viral RNA sensing PRR MDA5, central domain, DExD/H, RNA helices, helicase domain, protein structure, molecular biology, viral defense, innate immunity PRR, MDA5, central, DExD/H, RNA, helices, domain PRR MDA5, central domain, DExD/H, RNA helices, protein structure, molecular biology, helicase activity
1298	Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke. thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, DVT, hospital, immobile, acute, stroke, patients, prevention, treatment, efficacy, study, research, medical, clinical, trial, outcomes, risk, reduction, effectiveness, evidence, healthcare, intervention, surgery, mobility, clot, prevention, strategies, complications, neurological, disorders, vascular, issues, therapeutic, devices, sock, length, compression, levels, medical, equipment, stroke, recovery, rehabilitation, immobilization, thromboprophylaxis, prophylaxis, venous, thromboembol thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, hospital, patients, immobile, acute, stroke, prevention, efficacy, clinical, trials, medical, intervention, circulation, legs, blood, clot, risk, factors, treatment, outcomes, study, research, health, care, cardiovascular, disease, immobilization, recovery, rehabilitation, neurological, disorders, venous, insufficiency, prevention, strategies, evidence-based, practice, nursing, therapy, vascular, surgery, internal, medicine, neurology, pharmacology, biomechanics, patient, safety, quality, improvement thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, DVT, patients, hospital, immobile, acute, stroke, prevention, treatment, efficacy, medical, intervention, clinical, trial, research, findings, evidence, healthcare, study, results, risk, reduction, effectiveness, stroke, recovery, immobility, complications, vascular, health, outcomes thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, DVT, patients, hospital, immobile, acute, stroke, prevention, efficacy, study, medical, treatment, risk, reduction thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, reduction, patients, hospital, immobile, acute, stroke
513	High cardiopulmonary fitness causes increased mortality rate. high, cardiopulmonary, fitness, increased, mortality, rate, health, cardiovascular, exercise, physical, activity, aging, population, study, research, longevity cardiopulmonary fitness, mortality rate, health outcomes, physical fitness, cardiovascular health, exercise, longevity, health risks, medical studies, fitness benefits, death rate, survival rate, health correlations, physiological impacts High cardiopulmonary fitness, increased mortality rate, cardiovascular health, physical fitness, mortality risk, exercise physiology, health outcomes, fitness paradox, longevity, cardiovascular disease high cardiopulmonary fitness, increased mortality rate, fitness mortality paradox, cardiovascular health, exercise mortality, physical activity risks, cardiopulmonary exercise, fitness-related mortality, health outcomes fitness, cardiovascular fitness mortality cardiopulmonary fitness, mortality rate, high fitness, increased mortality, cardiovascular health, physical fitness, health outcomes, longevity, exercise benefits, fitness mortality paradox
514	High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter. calcium,dietary,intake,unnecessary,prevention,secondary,hyperparathyroidism,25(OH)D,levels,above,75,nmol/liter,vitamin,D,supplementation,bone,health,endocrinology,nutrition Calcium intake, secondary hyperparathyroidism, 25(OH)D, vitamin D levels, unnecessary, prevention, dietary calcium, subjects, nmol/liter high dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, 75 nmol/liter, prevention, unnecessary, subjects, vitamin D, calcium intake, hyperparathyroidism prevention, dietary calcium, vitamin D levels dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, mineral metabolism, bone health, renal function, supplementation, nutritional status, clinical guidelines High dietary calcium, unnecessary, prevention, secondary hyperparathyroidism, 25(OH)D levels, above 75 nmol/liter, vitamin D, calcium intake, hyperparathyroidism prevention, nutritional requirements, bone health, mineral metabolism
756	Many proteins in human cells can be post-translationally modified at lysine residues via acetylation. lysine, acetylation, post-translational, modification, human, cells, proteins proteins, human cells, post-translational modification, lysine residues, acetylation lysine, acetylation, post-translational modification, human cells, proteins lysine, acetylation, post-translational, modification, proteins, human, cells proteins, human cells, post-translational modification, lysine residues, acetylation
636	Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate. inositol, lipid, 3-phosphatase, PTEN, Ptdlns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemistry, cell, signaling, phospholipid, metabolism inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, metabolism inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemical, pathway Inositol,lipid,3-phosphatase,PTEN,PtdIns(3,4)P2,phosphatidylinositol,4-phosphate,biochemistry,enzymology,cellular,signaling,molecular,biology inositol, lipid, 3-phosphatase, PTEN, Ptdlns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemical, reaction
516	High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD). CRP, COPD, chronic obstructive pulmonary disease, inflammation, risk reduction, exacerbations, respiratory health, biomarkers, clinical outcomes, lung function CRP, COPD, exacerbations, chronic obstructive pulmonary disease, inflammation, biomarker, risk reduction, respiratory diseases, clinical outcomes, patient management CRP, COPD, chronic obstructive pulmonary disease, inflammation, risk reduction, exacerbations, biomarker, respiratory disease, health outcomes, clinical studies COPD, CRP, chronic obstructive pulmonary disease, C-reactive protein, exacerbations, inflammation, respiratory diseases, biomarkers, risk factors, clinical studies, pulmonary health, immune response CRP, COPD, exacerbations, chronic obstructive pulmonary disease, risk reduction, inflammation marker, respiratory disease, medical research, clinical studies, pulmonary health
637	Input from  mental and physical health care professionals is effective at decreasing homelessness. mental health, physical health, healthcare professionals, homelessness, input effectiveness, health interventions, social services, community health, poverty reduction, housing stability mental health, physical health, healthcare professionals, effectiveness, decreasing homelessness, input, intervention, support, treatment, community health, social services, policy, research, statistics, case studies, homeless population, mental disorders, physical illnesses, therapeutic approaches, multidisciplinary teams, outreach programs, housing solutions, preventative measures, public health initiatives, socioeconomic factors, recovery, rehabilitation, healthcare accessibility, quality of life, mental wellness, physical wellbeing, homelessness prevention, clinical recommendations, evidence-based practices, collaboration, integrated care, patient outcomes, health disparities, advocacy, funding, resources, healthcare policy, mental health services, physical health services, chronic conditions, mental health, physical health, healthcare professionals, homelessness, effective intervention, healthcare input, reducing homelessness, professional involvement, health and homelessness mental health, physical health, healthcare professionals, homelessness, effectiveness, intervention, treatment, support, recovery, community services mental health, physical health, healthcare professionals, homelessness, effectiveness, intervention, treatment, support services, community health, public health, social services, policy, research, statistics, case studies, testimonies, programs, prevention, recovery, integration, housing, stability, wellness
879	Occupancy of ribosomes by IncRNAs do not make functional peptides. ribosomes, IncRNAs, functional peptides, occupancy, RNA, protein synthesis, non-coding RNA, gene expression, molecular biology ribosomes, IncRNAs, occupancy, functional peptides, non-coding RNAs, translation, gene regulation, molecular biology, RNA function, protein synthesis ribosomes, IncRNAs, occupancy, functional peptides, non-coding RNAs, translation, gene expression, molecular biology, RNA function, ribosomal binding ribosomes, IncRNAs, functional peptides, occupancy, non-coding RNA, translation, gene expression, molecular biology, RNA function, protein synthesis IncRNAs, ribosomes, occupancy, non-coding RNAs, functional peptides, translation, molecular biology, gene regulation
517	High levels of copeptin decrease risk of diabetes. copeptin, diabetes, risk reduction, high levels, biomarker, preventative factor, endocrinology, health indicator, medical research, clinical studies copeptin, diabetes, risk reduction, high levels, biomarker, preventive factor, health indicator copeptin, diabetes, risk reduction, high levels, biomarker, health indicator, medical research, endocrinology, insulin resistance, glucose metabolism copeptin, diabetes, risk reduction, high levels, hormone, metabolic marker, preventive factor, health indicator copeptin, diabetes, risk reduction, high levels, biomarker, endocrinology, preventive medicine
759	Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission. Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact, prediction, treatment efficacy, parasite reduction, public health strategy, infectious disease modeling Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact reduction, drug efficacy, malaria control, public health intervention, infectious disease modeling Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact reduction, therapeutic strategies, disease control, public health intervention Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact analysis, disease control, public health strategies, pharmacology, infectious diseases, treatment efficacy Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact, prediction, treatment, parasites, gametocytes, antimalarial drugs, public health, disease control, epidemiology, infectious diseases, pharmacology, clinical outcomes, health interventions, drug efficacy, resistance management, vector-borne diseases
94	Albendazole is used to treat lymphatic filariasis. Albendazole, lymphatic filariasis, treatment, medication, parasitic infection, elephantiasis, neglected tropical disease, anti-helminthic, drug therapy Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, disease management, tropical medicine, parasitic infection Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, disease management, parasitic infection, elephantiasis, microfilariae, tropical medicine Albendazole, lymphatic filariasis, treatment, medication, parasitic infection, elephantiasis, roundworm, antihelmintic, dracunculiasis, river blindness, soil-transmitted helminths Albendazole, lymphatic filariasis, treatment, medication, parasitic infection, elephantiasis, filarial worms, drug therapy
99	Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding
1197	The availability of safe places to study is not effective at decreasing homelessness. safe places, study, homelessness, effectiveness, availability, impact, reduction, shelter, educational environments, urban planning, social services safe places, study areas, homelessness, effectiveness, shelter, education, urban planning, social services, public policy, community resources safe places, study, effectiveness, homelessness, reduction, shelters, public spaces, libraries, cafes, academic performance, social services, urban planning, policy, community resources, education, poverty, housing insecurity safe places, study, effectiveness, decreasing, homelessness, availability, impact, shelters, education, policy safe places, study areas, homelessness reduction, effectiveness, urban planning, social services, community resources, shelter availability, educational environment, public policy
1196	The availability of safe places to study is effective at decreasing homelessness. safe places, study areas, homelessness reduction, effective interventions, public spaces, community centers, libraries, social services, urban planning, shelter alternatives safe places, study, decreasing homelessness, availability, effectiveness, shelters, community centers, libraries, youth programs, support services safe places, study areas, homelessness reduction, public spaces, community centers, libraries, youth shelters, accessible resources, urban planning, social services safe places, study, decreasing, homelessness, availability, effective safe places, study areas, homelessness reduction, public spaces, community centers, libraries, youth shelters, educational environments, urban planning, social services
1194	The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'. arm density,TatAd complexes,structural rearrangements,Class1 TatAd complexes,charge zipper mechanism arm density,TatAd complexes,structural rearrangements,Class1 TatAd complexes,charge zipper mechanism arm density,TatAd complexes,structural rearrangements,Class1,charge zipper mechanism arm density, TatAd complexes, structural rearrangements, Class1 TatAd, charge zipper mechanism arm density, TatAd complexes, structural rearrangements, Class1, charge zipper mechanism
1191	The amount of publicly available DNA data doubles every 10 years. DNA, data, publicly, available, doubling, 10, years, genetics, genomics, exponential, growth, information, science, technology, research, databases, sequencing, bioinformatics DNA, data, public, doubling, 10 years, genomics, information growth, genetic information, biotechnology, data expansion DNA, data, publicly, available, doubles, 10, years, growth, exponential, genetics, genomics, information, expansion, doubling, time, scale, scientific, research, biological, databases, storage, technology, advancement, rate, increase, molecular, biology, sequencing, capacity, bioinformatics DNA data, public availability, doubling rate, genetic information, biotechnology growth, genomic databases, data expansion, molecular biology, genetic research, information science DNA, data, public, availability, doubling, years, genetics, genomics, information, growth, exponential, science, research, database, expansion, biotechnology
880	Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs ribosomes, IncRNAs, 5'UTRs, occupancy, gene expression, molecular biology, RNA binding, translation regulation ribosomes, IncRNAs, 5'UTRs, occupancy, RNA, transcriptomics, molecular biology, gene expression, non-coding RNA, translation regulation ribosomes, IncRNAs, 5'UTRs, occupancy, gene expression, RNA binding, translational regulation, molecular biology, non-coding RNAs, transcriptomics ribosomes, IncRNAs, 5'UTRs, occupancy, gene expression, non-coding RNAs, translation regulation, molecular biology, RNA binding, transcription factors ribosomes, IncRNAs, 5'UTRs, occupancy, RNA binding, gene expression, molecular biology, non-coding RNAs, translation initiation, cellular processes
882	Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians. omnivores, trimethylamine, N-oxide, dietary, L-carnitine, vegetarians, metabolism, gut, microbiota, cardiovascular, health omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, retrieval, improvement, query, nutrition, health, metabolism, dietary-habit, biochemical-response omnivores, trimethylamine, N-oxide, dietary, L-carnitine, vegetarians, metabolism, gut, microbiome, health, nutrition omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, retrieval, query, health, nutrition omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, metabolism, nutrition, health, dietary-habit, biochemical-difference, gut-microbiome
641	Insomnia can be effectively treated with cognitive behavioral therapy. insomnia, cognitive behavioral therapy, treatment, effective, mental health, sleep disorders, therapy, CBT, clinical psychology, sleep improvement Insomnia, Cognitive Behavioral Therapy, Treatment, Effectiveness, Sleep Disorders, Therapy, Mental Health, CBT, Clinical Studies, Patient Outcomes insomnia, cognitive behavioral therapy, treatment, sleep disorders, mental health, therapy effectiveness, behavioral interventions, sleep improvement, psychological treatment, non-pharmacological therapy insomnia, cognitive behavioral therapy, treatment, effectively, mental health, sleep disorder, therapy, CBT, psychological intervention insomnia, cognitive behavioral therapy, treatment, sleep disorders, therapy, mental health, CBT, effective treatment, sleep improvement, behavioral intervention
521	High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI). High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, onset symptoms, less than 3 hours, acute myocardial injury, AMI High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, onset symptoms, acute myocardial injury, AMI, less than 3 hours, cardiac biomarkers, myocardial infarction, troponin levels, early detection, clinical sensitivity, time-dependent diagnosis High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, symptoms onset, less than 3 hours, acute myocardial injury, AMI High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, symptoms onset, less than 3 hours, acute myocardial injury, AMI HSCT-T, dosage, diagnostic, symptoms, onset, less than 3 hours, acute myocardial injury, AMI
644	Insulin increases risk of severe kidney failure. Insulin, kidney failure, severe, risk, diabetes, complications, renal dysfunction, metabolic syndrome, glucoregulatory medication, nephropathy insulin, risk, severe, kidney, failure, diabetes, treatment, side, effects, nephropathy, medication, health, complications, medical, research, clinical, trials, patient, outcome, prognosis insulin, kidney, failure, risk, severe, diabetes, medication, nephropathy, treatment, health, outcomes, clinical, study, evidence, association, chronic, conditions, complications Insulin, kidney, failure, risk, severe, diabetes, treatment, complications, health, medication, nephropathy insulin, kidney failure, severe, risk, diabetes, renal disease, medication side effects, end-stage renal disease, glucose control, nephropathy
887	Only a minority of cells survive development after differentiation into stress-resistant spores. cell survival, development, differentiation, stress-resistant spores, minority cells, biological processes, spore formation, cellular differentiation, stress resistance, survival mechanisms cell survival, development, differentiation, stress-resistant spores, minority cells, spore formation, cellular differentiation, stress resistance, developmental biology cell survival, development, differentiation, stress-resistant spores, minority cells, biological processes, spore formation, cell fate, stress resistance, developmental biology cell survival, development, differentiation, stress-resistant spores, minority cells, biological processes, spore formation, cellular differentiation, stress resistance, developmental biology cell survival, development, differentiation, stress-resistant spores, minority cells, spore formation, cellular differentiation, stress resistance, microbial spores, biological development
525	Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors. Histone demethylase, nuclear receptors, transcription induction, histone methylation, ligand-dependent activation, chromatin modification, gene regulation, molecular biology, epigenetics, cellular signaling Histone demethylase, recruitment, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors Histone demethylase, transcription, nuclear receptors, ligand-dependent induction, histone methylation, gene expression, chromatin modification, cellular signaling, molecular biology, epigenetics Histone demethylase, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors Histone demethylase, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors
768	Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT). Mercaptopurine, inactive, methylmercaptopurine, thiopurine methyltransferase, TPMT, anabolized, metabolism, enzyme, pharmacology, drug metabolism Mercaptopurine, methylmercaptopurine, thiopurine methyltransferase, TPMT, anabolism, inactive metabolite mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT, metabolism, enzyme, pharmacology
527	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress. Homozygous deletion, murine, Sbds gene, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene expression, cell biology, mouse model, genetic modification, stem cell research, oxidative damage, cellular stress, Sbds deficiency, mesenchymal lineage, gene knockout, developmental biology homozygous deletion, murine, Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, genetic modification, stem cell research, mouse model, gene knockout, cellular biology, molecular genetics, oxidative damage, stem cell differentiation, progenitor cell function Homozygous deletion, murine, Sbds gene, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention, gene expression, mesenchymal lineage, stem cell biology, genetic modification, cell-specific deletion, mouse model, oxidative damage, stem cell differentiation, progenitor cell function Homozygous deletion, murine, Sbds gene, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention, genetic modification, stem cell research, mouse model, gene expression, cellular stress, molecular biology, genetics, stem cell biology, progenitor cell function, Sbds gene function, osterix-expressing cells, mesenchymal progenitor cells, genetic engineering, biological research, cell biology, medical research, genetic disorders, cellular biology, molecular genetics, gene knockout, gene regulation, stem cell differentiation, oxidative damage, cellular protection, gene Homozygous deletion, murine Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention, genetic modification, stem cell research, mouse model, gene knockout, cellular stress, mesenchymal progenitor cells, Sbds gene function, osterix role, stem cell biology, molecular genetics, cellular biology, gene expression, progenitor cell function, oxidative damage, genetic disorders, cell signaling, molecular mechanisms, biological pathways, gene regulation, tissue engineering, regenerative medicine
528	Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax. Human T-lymphotropic virus type-I, HTLV-I, myelopathy, tropical spastic paraparesis, HAM/TSP, patients, produce, Immunoglobulin G, IgG, antibodies, cross-react, immunodominant epitope, Tax protein Human T-lymphotropic virus type-I, HTLV-I, HAM/TSP, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, viral infection, neurological disorder, antibody response, immune system, medical research, virology, neurology Human T-lymphotropic virus type-I, HTLV-I, HAM/TSP, tropical spastic paraparesis, IgG antibodies, immunodominant epitope, Tax protein, cross-reactivity, viral infection, neurological disorder, immune response, antibody production, epitope recognition, pathogenesis, clinical immunology, virology, neurology, immunology, infectious diseases, autoimmune response, central nervous system, retroviral infection, diagnostic markers, therapeutic targets, research, medical science, public health, antibody specificity, virus-host interaction, immune system, epitope mapping, molecular mimicry, disease association Human T-lymphotropic virus type-I, HAM/TSP, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, immunodominant epitope, Tax protein, cross-reactivity, viral infection, neurological disorder, immune response, autoimmune reaction, viral protein, T-cell leukemia virus, HTLV-I, myelopathy, spasticity, neurodegenerative disease, antibody production, host-virus interaction, epitope mapping, immunology, virology, clinical immunology, neuroimmunology Human T-lymphotropic virus type-I, HAM/TSP, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, immunodominant epitope, Tax protein, cross-reactivity, viral infection, neurological disorder, immune response, antibody production, epitope recognition, viral epitope, host-virus interaction
649	Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance classroom-based collaborative learning, web-based collaborative learning, subpar class performance, educational technology, blended learning, student engagement, academic achievement, online collaboration, face-to-face interaction, learning outcomes integrated learning, classroom collaboration, web-based collaboration, performance outcomes, educational technology, student engagement, hybrid learning environments, academic achievement, collaborative tools, digital learning platforms classroom-based collaborative learning, Web-based collaborative learning, subpar class performance, integration challenges, educational technology, student engagement, learning outcomes, academic performance, collaborative methods, online learning, face-to-face interaction, hybrid learning models classroom-based collaborative learning, web-based collaborative learning, subpar class performance, educational strategies, learning outcomes, collaborative tools, online learning, face-to-face interaction, student engagement, academic achievement classroom-based collaborative learning, Web-based collaborative learning, subpar class performance, integration challenges, educational technology, student engagement, learning outcomes, blended learning, academic performance, collaborative tools, virtual collaboration, face-to-face interaction, online learning, educational strategies
1088	Silencing of Bcl2 is important for the maintenance and progression of tumors. Bcl2, silencing, tumor maintenance, tumor progression, oncogenes, apoptosis regulation, cancer therapy, molecular targeting, gene expression, cellular survival, therapeutic strategies Bcl2, silencing, tumor maintenance, tumor progression, apoptosis regulation, cancer treatment, gene expression, oncology, molecular biology, therapy target Bcl2, silencing, tumor maintenance, tumor progression, cancer genes, apoptosis regulation, oncogenesis, therapeutic targets Bcl2, silencing, tumor maintenance, tumor progression, cancer, apoptosis, gene expression, oncology Bcl2, silencing, tumor maintenance, tumor progression, oncology, cancer research, apoptosis regulation, genetic therapy, molecular biology, cancer genetics
1086	Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, improvement, treatment, sexual health, antidepressant side effects, pharmacotherapy Sildenafil, erectile dysfunction, SSRI antidepressants, sexual function, men, antidepressant-induced ED, ED treatment, pharmacotherapy, sexual health, medical intervention sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, treatment, improvement, pharmacotherapy, sexual health, antidepressant-induced dysfunction Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, treatment, sexual health, pharmacology, antidepressant side effects, male enhancement, medical intervention, sexual performance Sildenafil, erectile dysfunction, SSRI antidepressants, sexual function, men, antidepressant-induced ED, treatment, improvement, sexual health, pharmacotherapy
770	Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients, cancer treatment, chemotherapy comparison, oncology, elder patient care, cancer efficacy, quality of life in cancer patients metastatic colorectal cancer, single agent fluoropyrimidines, oxaliplatin-based chemotherapy, elderly patients, reduced efficacy, lower quality of life Metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, oxaliplatin, chemotherapy, elderly patients metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients
410	Febrile seizures increase the threshold for development of epilepsy. febrile, seizures, epilepsy, threshold, development, neurology, pediatric, brain, disorders, fever, convulsions, long-term, effects, risk, factors, treatment, prevention, neurological, outcomes febrile seizures, epilepsy, threshold, development, neurology, pediatric, seizures, brain, neurological disorders, treatment, prevention, risk factors Febrile seizures, epilepsy, threshold, development, neurology, seizures, brain disorders, pediatric neurology, epilepsy risk, fever-induced seizures febrile, seizures, epilepsy, threshold, development, neurology, pediatric, brain, disorders, clinical, studies, risk, factors, treatment, prevention Febrile, seizures, epilepsy, threshold, development, neurological, pediatric, brain, temperature, fever, risk, factors, clinical, outcomes, neurology, treatment, prevention, studies, research
411	Febrile seizures reduce the threshold for development of epilepsy. Febrile, seizures, epilepsy, threshold, development, reduce, neurological, disorders, pediatric, brain, temperature, fever, risk, factors, long-term, effects, prognosis, treatment, prevention Febrile, seizures, epilepsy, threshold, development, neurological, disorders, pediatric, neurology, brain, temperature, fever, risk, factors, prevention, treatment, prognosis, long-term, effects, clinical, studies, research, medical, health, childhood, epilepsy, predisposition, neural, excitability, inflammatory, response, synaptic, plasticity, genetic, predisposition, brain, injury, seizure, frequency, age, onset Febrile, seizures, epilepsy, threshold, development, neurological, conditions, pediatric, brain, dysfunction, long-term, effects, neurologic, consequences, clinical, studies, risk, factors, prevention, treatment Febrile, seizures, epilepsy, threshold, development, neurological, pediatric, brain, disorders, treatment, prevention, risk, factors, prognosis, management, clinical, studies, research, mechanisms, impact Febrile seizures, epilepsy, threshold, development, neurological disorders, pediatric neurology, seizure disorders, brain electrophysiology, neurodevelopmental disorders
532	Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis. hyperfibrinogenemia, femoropopliteal bypass, thrombosis, decreased rates, vascular surgery, blood clotting, fibrinogen levels, arterial surgery, limb ischemia, surgical outcomes hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, decreases, vascular, surgery, blood, clotting, disorders, fibrinogen, levels, limb, salvage, cardiovascular, risk, factors, clinical, outcomes, peripheral, artery, disease, intervention, treatment, prophylaxis Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, decreased rates, surgery outcomes, vascular surgery, blood clotting, fibrinogen levels, peripheral artery disease, surgical complications Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, blood, clotting, vascular, surgery, hemostasis, fibrinogen, levels, clinical, studies, outcomes, risk, factors, peripheral, arterial, disease, intervention, patency, rates, medical, treatment, prevention Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, decrease, vascular, surgery, blood, clotting, disorders, fibrinogen, levels, arterial, graft, patency, hemostasis, cardiovascular, risk, factors, medical, treatment, prevention
533	Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis. Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, vascular, surgery, complications, blood, clotting, disorders, risk, factors, limb, ischemia, treatment, prognosis, medical, research, clinical, studies, patient, care, outcomes, intervention, prevention, strategies, healthcare, providers, arterial, disease, peripheral, circulation, pathology, hemostasis, coagulation, fibrinogen, levels, blood, tests, diagnosis, management, therapeutic, approaches, cardiovascular, system, health, science, biology, medicine, interventions, public, health, epidemiology, statistics Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, blood, clotting, vascular, surgery, risk, factors, medical, conditions, circulation, limbs, healthcare, treatment, outcomes, complications, patient, care Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, surgery, vascular, blood, clotting, disorders, treatment, prevention, risk, factors, clinic, study, research, medical, health Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood clotting disorders, peripheral artery disease, surgical complications, hypercoagulable states, fibrinogen levels, circulatory disorders Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood clotting, arterial disease, Peripheral artery disease, surgical complications, hypercoagulability, fibrinogen levels
775	Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR). Mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR Mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR Mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR Mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR
1199	The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins. colchicine, benefits, secondary prevention, high-dose statins, widespread use, cardiovascular disease, treatment, pharmacotherapy colchicine, benefits, secondary prevention, high-dose statins, cardiovascular, medication, treatment, health outcomes, pharmacology, clinical studies colchicine, benefits, secondary, prevention, strategies, high-dose, statins, widespread, use, effective colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, treatment, pharmacology, clinical outcomes, medication adherence, cholesterol management, inflammation reduction, heart attack prevention, stroke prevention colchicine, benefits, secondary prevention, strategies, high-dose statins, effective use, widespread application, cardiovascular disease, pharmacotherapy, lipid management
535	Hypertension is frequently observed in type 1 diabetes patients. Hypertension, Type 1 Diabetes, Co-morbidity, Blood Pressure, Insulin-dependent Diabetes, Cardiovascular Risk, Renal Function, Clinical Management, Glycemic Control, Hypertensive Disorders hypertension,type 1 diabetes,observed,frequency,clinical association,blood pressure,diabetes complications,cardiovascular risk hypertension,type 1 diabetes,diabetes complications,cardiovascular risk,blood pressure management,diabetic nephropathy,clinical outcomes,health monitoring hypertension,type 1 diabetes,patients,blood pressure,diabetes mellitus,clinical conditions,health issues,cardiovascular risks hypertension,type 1 diabetes,observed,frequency,patients,blood pressure,diabetes mellitus,clinical prevalence
415	Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia. female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia Female, carriers, Apolipoprotein, E4, APOE4, allele, increased, risk, dementia female carriers, Apolipoprotein E4, APOE4 allele, increased risk, dementia female carriers, Apolipoprotein E4, APOE4 allele, increased risk, dementia Female, carriers, Apolipoprotein, APOE4, allele, increased, risk, dementia
536	Hypocretin neurones induce panicprone state in rats. hypocretin neurones, panic-prone state, rats, neurological research, behavioral neuroscience, anxiety disorders, brain chemistry, neural mechanisms, stress response, animal studies hypocretin, neurones, panic-prone, state, rats, induction, neuroscience, anxiety, behavioral, response, neurotransmitters, brain, research, model, stress, fear, physiological, mechanisms Hypocretin, neurones, panic-prone, state, rats, induction, anxiety, neurobiology, neuroscience, behavior, animal, model, stress, response, brain, chemistry, neurotransmitters, sleep, disorders Hypocretin, neurones, panic-prone, state, rats, induction, neurobiology, anxiety, animal, model, neuroscience, fear, stress, brain, research Hypocretin, neurones, panic-prone, state, rats, anxiety, neuroscience, research, brain, behaviour
659	Ivermectin is used to treat lymphatic filariasis. Ivermectin, lymphatic filariasis, treatment, medication, parasitic disease, elephantiasis, tropical medicine, antiparasitic, drug therapy, filariasis treatment Ivermectin, lymphatic filariasis, treatment, parasitic disease, antiparasitic, medication, elephantiasis, filaria, worm infection, tropical medicine Ivermectin, lymphatic filariasis, treatment, medication, parasitic disease, elephantiasis, anti-parasitic, drug therapy Ivermectin, Lymphatic filariasis, Treatment, Medication, Parasitic infection, Drug therapy Ivermectin, lymphatic filariasis, treatment, antiparasitic, drug, disease management, tropical medicine, parasitology
539	Hypoglycemia increases the risk of dementia. Hypoglycemia, dementia, risk, health, brain, glucose, seniors, cognitive, decline, diabetes, neurological, impact, association, study, medical, prevention, treatment, symptoms, complications Hypoglycemia, dementia, risk, health, glucose, brain, diabetes, cognitive, decline, elderly, prevention, treatment, research, study, impact, association, neurological, disorders, medical, conditions, insulin, therapy, complications, brain, function, neurological, damage, cognitive, impairment, mental, health, age, related, diseases, clinical, trials, evidence, health, care, professional, advice, monitoring, blood, sugar, levels, management, strategies, patient, education, awareness, public, health, policy, recommendations, guidelines hypoglycemia, dementia, risk, association, health, brain, cognitive, diabetes, elderly, prevention hypoglycemia, dementia, risk, health, brain, glucose, cognitive, older, adults, medicine, neurodegeneration, insulin, treatment, prevention, studies, research hypoglycemia, dementia, risk, brain, glucose, neurodegeneration, cognitive, impairment, low, blood, sugar, elderly, diabetes, association, study, research, health, impact, mechanism
1099	Statins decrease blood cholesterol. statins, cholesterol, blood, decrease, lipid, cardiovascular, treatment, medication, health, prevention Statins, cholesterol, blood, decrease, lipid, heart, medication, treatment, levels, reduction statins, blood, cholesterol, decrease, lipid, cardiovascular, health, medication, treatment, prevention Statins, blood, cholesterol, decrease, lipid, heart, health, medication, treatment statins, blood, cholesterol, decrease, lower, levels, cardiovascular, risk, treatment, medication, lipids, health, prevention, heart, disease, HDL, LDL, triglycerides, side, effects, benefits, medical, therapy, drugs, pharmacology, clinical, trials, research, evidence, usage, prescription, dosage, patient, care, management, guidelines, review, article, study, report, summary, statistics, data, analysis, comparison, effectiveness, safety, profile, mechanism, action, biology, biochemistry, pharmacodynamics, pharmacokinetics, absorption, distribution, metabolism, excretion, toxicity
660	Ivermectin is used to treat onchocerciasis. Ivermectin, Onchocerciasis, Treatment, River Blindness, Parasitic Infection, Medication, Health, Disease Management, Tropical Medicine, Anthelmintic Ivermectin,onchocerciasis,treatment,medication,parasitic,disease,anti-parasitic,therapy Ivermectin,onchocerciasis,treatment,parasitic disease,river blindness,medication,anti-parasitic,pharmaceutical therapy Ivermectin, Onchocerciasis, Treatment, Medication, Parasitic, Disease, Health, Medicine, Infection, Therapy Ivermectin,onchocerciasis,treatment,antiparasitic,medication,river blindness,disease,therapy
781	Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis. Mice, Interferon-γ, Receptor, Experimental, Autoimmune, Myocarditis, Resistance, Knockout, Immune, Cardiac, Inflammation, Disease, Model, Genetic, Mutation, Cytokine, Signaling, Pathway, Autoimmunity, Heart, Tissue, Damage, Protection, Susceptibility, Mechanism, Research, Study, Biology, Medicine Interferon-γ, receptor, mice, experimental, autoimmune, myocarditis, resistance, knockout, inflammation, cardiac, autoimmunity, cytokine, deficiency, disease model, immunology Mice, Interferon-γ, receptor, resistance, experimental, autoimmune, myocarditis, knockout, immune response, cardiac inflammation Mice, Interferon-γ, Receptor, Resistance, Experimental, Autoimmune, Myocarditis, Knockout, Immunity, Cardiac, Inflammation, Disease, Model, Genetically, Modified, Animal, Study, Pathology, Cytokine, Deficiency Mice, Interferon-γ, Receptor, Resistance, Experimental, Autoimmune, Myocarditis, Lack, High, Immunology, Cardiology, Autoimmunity, Cytokines, Genetics, Animal, Models, Heart, Disease, Inflammation, Research, Biology
540	Hypothalamic glutamate neurotransmission is crucial to energy balance. hypothalamus, glutamate, neurotransmission, energy, balance, metabolism, neurobiology, signaling, homeostasis, obesity, neural, pathways, appetite, regulation Hypothalamus, Glutamate, Neurotransmission, Energy, Balance, Metabolism, Neuroscience, Brain, Signaling, Homeostasis hypothalamus, glutamate, neurotransmission, energy, balance, metabolism, neural, regulation, obesity, appetite Hypothalamus, Glutamate, Neurotransmission, Energy, Balance, Metabolism, Neurons, Signaling, Regulation, Obesity, Weight, Control, Neural, Circuits, Physiology, Endocrinology, Appetite, Control, Feeding, Behavior Hypothalamic, Glutamate, Neurotransmission, Energy, Balance, Metabolism, Regulation, Neuroscience, Physiology
783	Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA. Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, immunity, inflammation, autoimmune, myocarditis Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, autoimmunity, inflammation, myocarditis Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, autoimmune, myosin, carditis, inflammation, cytokine, immune response, experimental autoimmune myocarditis, interferon gamma, myosin heavy chain, complete Freund's adjuvant Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, immunology, autoimmunity, cardiology, inflammation, cytokines, experimental autoimmune myocarditis, interferon gamma, myosin heavy chain, complete freund's adjuvant Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, autoimmune, myocarditis, immunology, inflammation, knockout, model, disease, resistance, α-myosin, cardiac, adjuvant, immune response
300	Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake. cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, mRNA regulation, iron metabolism cytosolic proteins, iron-responsive elements, mRNAs, DMT1, proteins, iron uptake Cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, mRNA regulation, iron metabolism Cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, mRNA binding, iron metabolism, cellular iron, transcription regulation cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, iron metabolism, mRNA binding, cellular iron regulation
421	Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules. Flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, cancer treatment, drug delivery, pharmacokinetics, biomolecular interactions flexible,molecules,steric,hindrance,tumor,microenvironment,rigid,molecules,cancer,drug,delivery,bioavailability,pharmacokinetics,treatment,effectiveness,molecular,structure,cell,permeability,tumor,penetration flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, tumor environment, steric effects, drug delivery, cancer treatment, molecular structure, bioavailability, therapeutic efficiency Flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, cancer therapy, drug delivery, tumor penetration, molecular dynamics, bioavailability flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, tumor penetration, drug delivery, cancer therapy, molecular dynamics, biomolecular interactions
784	MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, stem cell biology, neurogenesis, molecular biology, cell cycle, tissue homeostasis, neuroscience, developmental biology MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, stem cell biology, miRNA, neural development MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, neurogenesis, stem cell biology, cell cycle control, nervous system development MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, neurogenesis, stem cell biology MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, stem cell biology, miRNA, neurogenesis, cell cycle, molecular biology, neuroscience
785	Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures. microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, poor, biological, samples, analysis, diagnostics, virology, genetics microarray, culture-amplified, serotypes, correlate, poorly, uncultured, mixtures microarray, culture-amplified, mixtures, serotypes, correlate, poorly, uncultured, results, retrieval, improvement, query, optimization, biological, analysis, data, interpretation, genetics, molecular, biology, diagnostics, research, science, technology, bioinformatics, genomics, transcriptomics microarray, culture-amplified, mixtures, serotypes, correlation, uncultured, results, poor, comparison, genetic, analysis, virology, biology, methodology microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, poor, retrieval, improvement
544	IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs. IFIT1, viral replication, sequestrating, mis-capped, viral RNAs, antiviral, immune response, RNA binding, protein interaction, infection control IFIT1, viral replication, sequestration, mis-capped RNAs, antiviral mechanism, immune response, RNA binding, virus restriction, protein-RNA interactions, innate immunity IFIT1, viral replication, sequestration, mis-capped, viral RNAs, antiviral mechanism, immune response IFIT1, viral replication, sequestrating, mis-capped, viral RNAs, antiviral mechanism, immune response, RNA binding, infection control, cellular defense IFIT1, viral replication, sequestration, mis-capped RNAs, antiviral defense, RNA binding, host defense, immune response, viral infection, gene expression
303	DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region. DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, chromosomal sex determination, DNA methylation, histone modification, sexual development, genetic regulation DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosomal sex determination, gene expression, epigenetics, sexual development, molecular biology, genetics DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosomal sex determination, gene expression, epigenetics, sexual development, molecular biology, genetics DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosomal sex determination, gene expression control, developmental biology, genetics, molecular biology, sex chromosomes DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, chromosomal sex determination, molecular biology, genetics, epigenetics
1089	Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. Smc5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement, molecular biology, protein interaction, cell biology, biochemical process, ATP-dependent, enzymology, ubiquitination pathway, SUMOylation, chromosomal maintenance, DNA repair, cellular regulation SMC5/6, Mms21, SUMO, E3 ligase, ATP, remodeling, activation, engagement, protein complex, post-translational modification, molecular biology, cell cycle regulation, DNA repair SMC5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement Smc5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement SMC5/6, Mms21, SUMO E3 ligase, ATP-dependent remodeling, protein activation, molecular biology, cell biology, protein-protein interactions, ATPase activity, chromatin remodeling
549	IRG1 has antiviral effects against neurotropic viruses. IRG1, antiviral, neurotropic, viruses, immunity, infection, neuroscience, virology, gene, protein, therapeutic, target, pathogen, host, response, mechanism, treatment, prevention, research, medical, biology, health, disease, cell, signaling, pathway, inflammation, cytokines, immune, response, viral, infection, protection, inhibition, replication, virus, brain, nervous, system, neurology, microglia, astrocytes, neurons, glial, cells, cytokine, storm, interferon, innate, immunity, adaptive, immunity, clinical, trials, drug, IRG1, antiviral, neurotropic, viruses, immune response, gene function, viral infection, neuroprotection IRG1, antiviral, neurotropic, viruses, immunity, infection, neuroscience, virology IRG1, antiviral, neurotropic, viruses, immune response, gene expression, viral infection, neurological viruses, immunology, virology, antiviral protein IRG1, antiviral, neurotropic, viruses, immune response, gene expression, viral infection, neurological viruses, host defense, pathogen resistance
551	ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, prevention, immunology, cell signaling, biochemistry ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, prevention, signal transfer ITAM, phosphorylation, T cell receptor, TCR, echo-domain, cytoplasmic tail, signal transfer, immunology, cell signaling, T-cell activation ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic, tail, T-cell, receptor, prevention, transfer ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, immunology, cell signaling, biochemistry
793	Mitochondria are uninvolved in apoptosis. mitochondria, apoptosis, cell death, uninvolved, role, biological processes, mitochondria function, apoptosis mechanism mitochondria, apoptosis, uninvolved, cell-death, mitochondrial-dysfunction, biological-processes, cellular-mechanisms, scientific-research, biochemistry, cell-biology mitochondria, apoptosis, cell death, mitochondrial function, apoptosis signaling, mitochondria role, cell survival, apoptosis pathway, mitochondria involvement, apoptosis regulation mitochondria, apoptosis, uninvolved, cell-death, biochemistry, molecular-biology mitochondria, uninvolved, apoptosis, cell-death, biological-processes, mitochondria-function, apoptosis-mechanisms
431	FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS). FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, mediation, neurodegeneration, oxidative, stress, signaling, pathway FoxO3a, activation, neuronal, death, mediated, reactive, oxygen, species, ROS FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, mediation, neurodegeneration, oxidative, stress, signaling, pathways, cell, survival, apoptosis FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, mediation, neurodegeneration, oxidative, stress, signaling, pathways, apoptosis, neurons, brain, cellular, damage, antioxidants, molecular, mechanisms, neuroprotection FoxO3a, neuronal death, reactive oxygen species, ROS, activation, mediation, neurodegeneration, oxidative stress, cell signaling, apoptosis
552	IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet. IgA, plasma, cells, transglutaminase, 2, duodenal, mucosa, gluten-free, diet, accumulation, specificity, celiac, disease, immune, response, treatment, diagnosis IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, immune response, gut microenvironment, dietary intervention, autoantibodies IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, accumulation, celiac disease, dietary intervention, immune response, autoantibodies IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, dietary impact, immune response, mucosal immunity, gluten sensitivity IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, accumulation, celiac disease, intestinal immunity, dietary intervention, autoimmune response
674	LDL cholesterol has no involvement in the development of cardiovascular disease. LDL, cholesterol, cardiovascular, disease, involvement, development, health, lipid, profile, heart, risk, factors LDL, cholesterol, cardiovascular, disease, involvement, development, health, blood, lipids, heart, medical, research, studies, evidence, risk, factors, prevention, treatment, biology, mechanism LDL, cholesterol, cardiovascular, disease, involvement, development, health, lipids, blood, heart LDL, cholesterol, cardiovascular, disease, involvement, development, lipid, atherosclerosis, health, risk, factors, CVD, preventive, medicine, lipid, profile, blood, fats, heart, stroke LDL, cholesterol, cardiovascular, disease, involvement, development, health, blood, fats, arteries
312	De novo assembly of sequence data has more specific contigs than unassembled sequence data. de novo assembly, sequence data, specific contigs, unassembled data, bioinformatics, genomics, sequencing, assembly quality, contig specificity, data processing de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genomic assembly, next-generation sequencing, NGS, contig specificity, assembly quality de novo assembly, sequence data, specific contigs, unassembled sequence, genome assembly, bioinformatics, sequencing technologies, contig quality, assembly methods, genetic data analysis de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genome assembly, read assembly, contig specificity, sequencing technology, NGS data, assembly quality, genetic data processing de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genome assembly, NGS, contig specificity, sequencing technologies, data assembly methods
554	Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1. Immune complex, cell death, neutrophil, HMGB1, extracellular release, inflammation, immune response, protein release, apoptosis, necrosis Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, apoptosis, necrosis, immune-mediated signaling Immune complex, cell death, neutrophil protein, HMGB1, extracellular release, inflammation, immune response, apoptosis, necrosis, signaling pathways Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, neutrophils, protein release, immunology immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, neutrophils, protein release, apoptosis, necrosis, immune-mediated cell death
314	Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome. deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, catastrophic mutations deamination,cytidine,uridine,viral,DNA,minus,strand,G-to-A,mutations,catastrophic,viral,genome deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, catastrophic mutations, nucleotide conversion, viral replication error deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, catastrophe deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, catastrophic mutations, nucleotide conversion, reverse transcription error
436	Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated. Rad53, DNA replication, histone degradation, free histones, cell cycle,checkpoint kinase, yeast genetics, molecular biology histones, degraded, Rad53-dependent, mechanism, DNA, replicated, free, cells, molecular, biology, genetics, replication, protein, degradation, checkpoint, kinase Free histones, Rad53-dependent mechanism, DNA replication, protein degradation, cell cycle, chromatin assembly, replication-coupled histone turnover Free histones, Rad53-dependent mechanism, DNA replication, histone degradation, cell cycle regulation, yeast genetics, molecular biology, protein degradation, DNA replication checkpoint, Rad53 kinase Free histones, Rad53-dependent degradation, DNA replication, chromatin assembly, cell cycle regulation, protein degradation, nucleosome formation, histone turnover
437	Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model. Functional consequences, genomic alterations, Myelodysplastic syndrome, MDS, animal model, research gap, hematopoiesis, genetic mutations, cancer biology, molecular mechanisms Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, MDS, research gaps, genetic disorders, hematopoietic stem cells, cancer genetics, molecular biology Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research gaps, hematopoietic disorders, genetic mutations, bone marrow failure, leukemia transformation, therapeutic targets Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research challenges, hematopoietic disorders, genetic mutations, MDS models, cellular mechanisms, treatment strategies Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research gap, hematopoietic disorders, genetic mutations, bone marrow failure, leukemia progression, molecular mechanisms
439	Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation Fz, PCP, Pk, anterior, membrane, neuroectoderm, cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation, cell polarization, developmental biology, embryogenesis Fz, PCP, Pk, anterior, membrane, neuroectoderm, cells, zebrafish, neuralation Fz, PCP, Pk, anterior, membrane, neuroectoderm, cells, zebrafish, neuralation, localization, development, signaling, polarity, embryo, tissue, morphogenesis
560	Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs. Immune responses, inflammatory, Th17 cells, anti-inflammatory, iTregs, development, immune system, T cells, regulatory T cells, inflammation, adaptive immunity, cytokines, immune regulation Immune responses, inflammatory, Th17 cells, anti-inflammatory, iTregs, development, immune system, T-cell differentiation, cytokines, inflammation, regulatory T cells Immune responses, inflammatory, Th17 cells, anti-inflammatory, iTregs, development, immune system, T cells, regulatory T cells, inflammation, autoimmune diseases, cytokines, cellular immunity, adaptive immunity Immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, cell development, immune regulation, Th17, iTregs, inflammation, immune cell differentiation, adaptive immunity Immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, Th17 cells, iTregs, immune system, inflammation, regulatory T cells, adaptive immunity, cytokines, immune regulation, cell differentiation
440	Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation. Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neurulation, developmental biology, cell polarization, vertebrate development Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation, localization, developmental biology, cell polarity, morphogenesis, embryology Fz, PCP, Pk, anterior, membrane, notochord, cells, zebrafish, neuralation
1303	Tirasemtiv has no effect on fast-twitch muscle. Tirasemtiv, fast-twitch muscle, muscle effect, no effect, pharmacology, muscle research, clinical trials, muscle contraction, drug efficacy, skeletal muscle Tirasemtiv, fast-twitch muscle, no effect, muscle function, pharmacology, muscle response, drug efficacy Tirasemtiv, fast-twitch muscle, no effect, muscle response, pharmacology, muscle fibers, treatment outcome Tirasemtiv, fast-twitch muscle, effect, muscle response, pharmacology, muscle fibers, clinical trials, drug efficacy, no effect, muscle contraction Tirasemtiv, fast-twitch muscle, no effect, muscle response, pharmacology, muscle fibers, treatment outcomes, clinical trials, muscle function, drug efficacy
684	Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells. Bacillus subtilis, sporulation efficiency, clpC gene, genetic deletion, bacterial physiology, sporulation process, gene function, molecular biology, microbial genetics Bacillus subtilis, sporulation efficiency, clpC gene, gene deletion, bacterial genetics, molecular biology, microbial physiology Bacillus subtilis, clpC, sporulation efficiency, genetic mutation, bacterial cells, molecular genetics, microbiology, gene function, protein ClpC, sporulation process Bacillus subtilis, clpC, sporulation efficiency, gene knockout, molecular genetics, bacterial sporulation, proteolysis, chaperone proteins Bacillus subtilis, sporulation efficiency, clpC, genetic mutation, bacterial physiology, molecular biology, microbiology, gene function, spore formation, protein ClpC
443	GATA-3 is important for hematopoietic stem cell (HSC) function. GATA-3, hematopoietic, stem, cell, function, HSC, transcription, factor, development, differentiation, blood, progenitor, regulation, signaling, maintenance, proliferation, survival GATA-3, hematopoietic, stem, cell, function, HSC, transcription, factor, blood, development, differentiation, regulation, lineage, commitment GATA-3, hematopoietic stem cells, HSC function, transcription factor, blood cell development, stem cell maintenance, hematopoiesis regulation GATA-3, hematopoietic stem cell, HSC function, transcription factor, blood cell development, immune system, stem cell regulation, gene expression, hematopoiesis, cellular differentiation GATA-3, hematopoietic stem cell, HSC, function, importance, regulation, blood cell development, immune system, transcription factor, stem cell maintenance
324	Deleting Raptor reduces G-CSF levels. Deleting, Raptor, reduces, G-CSF, levels, G-CSF reduction, Raptor deletion, cytokine levels, protein regulation, immune response modulation Deleting Raptor, G-CSF levels, reduction, Raptor deletion, Granulocyte colony-stimulating factor, protein levels, molecular biology, genetics, cellular signaling, immune response raptor, g-csf, levels, deletion, reduction, signaling, protein, mouse, human, study, research, biology, medicine, treatment, disease, inflammation, neutrophils Deleting,Raptor,G-CSF,levels,reduces Deleting, Raptor, reduces, G-CSF, levels, G-CSF reduction, Raptor deletion, cytokine levels, immune response, protein degradation, cellular signaling, hematopoiesis, neutrophil production
327	Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype. αvβ8, deletion, inflammatory, phenotype, spontaneous, integrin, mice, research, immunology, cell-adhesion αvβ8, deletion, inflammatory, phenotype, spontaneous, immune response, integrin, knockout, mice, genetics, inflammation, cell adhesion, molecular biology, research, science αvβ8, deletion, inflammatory, phenotype, spontaneous, immune response, integrin, knockout, mice, tissue homeostasis αvβ8, deletion, inflammatory phenotype, spontaneous, integrin, knockout, mice, immune response, inflammation, genetics, cell adhesion, signaling pathways Deletion, αvβ8, spontaneous, inflammatory, phenotype, genetics, immunology, cell biology, knockout, mice, inflammation, absence, health, molecular biology, receptors, integrins, biological processes, disease models, research, science
569	In adult tissue, most T cells are memory T cells. adult tissue, T cells, memory T cells, immune system, lymphocytes, cellular immunity, adaptive immunity, immunology, memory cells, mature T cells adult tissue, T cells, memory T cells, immune system, lymphocytes, cell-mediated immunity, adaptive immunity, T cell development, T cell subsets, T cell function adult tissue, T cells, memory T cells, immune system, lymphocytes, adaptive immunity, cell-mediated immunity, immunology, human body, cellular memory, antigen-specific cells, long-lived T cells, effector T cells, naïve T cells, T cell development, T cell activation, T cell function, T cell repertoire, T cell subsets adult tissue, T cells, memory T cells, immune system, lymphocytes, cellular immunity, adaptive immunity, immunology, T cell development, T cell subsets adult tissue, T cells, memory T cells, immune system, lymphocytes, cell-mediated immunity, adaptive immunity, immunology, human body, blood cells
208	CHEK2 is not associated with breast cancer. CHEK2, breast cancer, association, negative association, cancer genetics, genetic markers, oncology, tumor suppressor genes, mutation analysis, clinical studies, epidemiology, genetic disorders, molecular biology, medical research, gene expression, proteomics, bioinformatics, carcinogenesis, risk factors, hereditary cancer syndromes CHEK2, breast cancer, genetic association,否定关联, non-linkage, oncology, molecular genetics, cancer research, clinical studies, epidemiology CHEK2, breast cancer, genetic association, oncology, cancer research, gene mutations, tumor suppressor genes, hereditary cancer, clinical genetics, molecular biology CHEK2, breast cancer, genetic association, oncology, mutation, genetic marker, cancer risk, tumor suppressor gene, genomic studies, false negative, clinical genetics CHEK2, breast cancer, association, genetic linkage, oncology, cancer research, mutation analysis, risk factors, clinical studies, epidemiology
690	Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic disorder, rare disease, pediatric case study, clinical research, biochemical marker gabonese, children, Schimmelpenning-Feuerstein-Mims, syndrome, SFM, plasma, lactate, 5mmol/L, less, 10% gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic disorder, rare disease, pediatric case study, medical research, biochemical markers Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic disorder, rare disease, pediatric condition Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, less than 10%
691	Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation. Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, represses, response, signaling pathway, cancer research, molecular biology, cell signaling, protein interaction, oncology, leukemia treatment, genetic factors, cellular response, Rho GTPase, signal transduction, biomedical research, therapeutic targets Leukemia, Rho, guanine, nucleotide-exchange, factor, represses, RhoA, response, SRC, activation, cancer, protein, signaling, pathway Leukemia, Rho, guanine, nucleotide-exchange, factor, represses, RhoA, response, SRC, activation, cancer, signaling, protein, interaction, molecular, biology, inhibition, oncology Leukemia, Rho, Guanine, Nucleotide-exchange, Factor, Represses, RhoA, Response, SRC, Activation Leukemia, Rho, guanine, nucleotide-exchange, factor, represses, RhoA, response, SRC, activation, cancer, signaling, protein, interaction, cellular, regulation, oncogene, pathology, biochemistry, molecular, biology, genetics, hematopoietic, cells, tyrosine, kinase, downstream, effectors, GTPase, cycle, disease, mechanism, therapeutic, targets, research, medical, science, inhibitors, treatments, prognosis, diagnosis, therapy, clinical, trials, studies, expression, pathways, phosphorylation, signal, transduction, dynamics, function, structural
692	Leuko-increased blood increases infectious complications in red blood cell transfusion. leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, pathogens, hematology, transfusion, medicine, immunity, inflammation, patient, care, clinical, outcomes leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, infection, transfusion-related, immunology, hematology, medical, research, patient, care, clinical, studies leukocytes, increased, blood, infectious, complications, red, blood, cell, transfusion, leuko-increased, transfusion-related, infection, hematology, transfusion-medicine leukocytes, blood, infection, complications, red blood cell transfusion, leuko, increased, infectious leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, inflammation, infection, transfusion-related, immunology, hematology
1316	Transferred UCB T cells acquire a memory-like phenotype in recipients. UCB T cells, memory-like phenotype, recipients, cell transfer, immune response, T cell differentiation, adoptive cell therapy transferred, UCB, T cells, acquire, memory-like, phenotype, recipients, immunotherapy, cellular, therapy, hematopoietic, stem, cells, adoptive, transfer, immune, response, cancer, treatment UCB T cells, memory-like phenotype, recipients, cell transfer, immunology, T cell differentiation, adoptive cell therapy, cellular immunology, immune memory, transplant immunology Transferred, UCB, T cells, memory-like, phenotype, recipients UCB, T cells, memory phenotype, recipients, transferred cells, immune response, cell therapy, hematopoietic stem cells, immunology, transplantation medicine
693	Leuko-reduced blood reduces infectious complications in red blood cell transfusion. Leukoreduced, blood, infectious, complications, red, cell, transfusion, reduction, leukocytes, contamination, hematology, transfusion, safety, efficacy, medical, treatment, blood, banking, immunology, clinical, studies, evidence, practice, guidelines leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, reduction, pathogens, immune, response, safety, hematology, transfusion, medicine, clinical, trials, evidence, practice leuko-reduced blood, infectious complications, red blood cell transfusion, transfusion safety, hematologic therapy, blood component treatment, leukocyte reduction, transfusion medicine, immunological response, clinical outcomes leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, reduction, contamination, immune, response, allogeneic, transfusion, therapy, safety, hematology, transfusion, medicine Leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, medical, treatment, hematology, transfusion, safety, leukocytes, removal, clinical, outcomes, patient, care
452	Gene expression does not vary appreciably across genetically identical cells. gene expression, identical cells, genetic consistency, cellular variability, transcriptome stability, mRNA levels, genetic homogeneity, cellular gene regulation gene expression, genetically identical cells, cellular variability, transcriptional consistency, molecular biology, cell genetics, gene regulation, identical cell analysis, expression level stability, genetic homogeneity gene expression, genetically identical cells, cell-to-cell variability, transcriptional regulation, molecular biology, genetics, cell biology, expression consistency, genetic identicality, biological replication gene expression, genetically identical cells, variation, consistency, molecular biology, cellular genetics, transcriptomics, RNA sequencing, clonal cells, expression stability gene expression, genetically identical cells, variation, consistency, cellular genetics, transcriptomics, single-cell analysis
212	CR is associated with higher methylation age. CR, methylation, age, epigenetic, DNA, modification, cellular, senescence, aging, biomarker, health, longevity CR, higher, methylation, age, association, epigenetic, aging, calorie, restriction, biomarker, longevity, healthspan CR, higher, methylation, age, epigenetic, aging, DNA, methyltransferase, biomarker, healthspan, lifespan, dietary, restriction, cellular, senescence, oxidative, stress, metabolism, genetic, modification CR, methylation, age, higher, association CR, higher, methylation, age, epigenetic, aging, caloric, restriction, DNA, modification, cellular, longevity, healthspan, biomarker
575	In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon. Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, genetic variation, yeast genetics, chromosome stability, aneuploidy frequency, yeast strains, genetic disorders, chromosomal abnormalities Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, uncommon, yeast, aneuploidy frequency, genetic disorders, chromosome abnormalities Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, genetic variation, yeast genetics, chromosome stability, aneuploidy frequency, genomic studies, yeast strains, molecular biology Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, genetic variation, yeast genetics, chromosome stability, aneuploidy frequency Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, uncommon, yeast genetics, chromosomal abnormalities, genomic stability
213	CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. CRP, postoperative mortality, CABG surgery, coronary artery bypass graft, predictive value, inflammatory markers, surgical outcomes, cardiovascular surgery, patient prognosis, medical research CRP, postoperative, mortality, CABG, surgery, predictive, inflammation, cardiovascular, outcomes, surgical, risk, factors, prognosis CRP, postoperative, mortality, CABG, surgery, predictive, cardiovascular, inflammation, outcomes, clinical, research, medicine CRP, postoperative mortality, Coronary Artery Bypass Graft, CABG surgery, predictive value, cardiovascular surgery, inflammatory markers, surgical outcomes, patient recovery, medical prognosis CRP, postoperative, mortality, CABG, surgery, predictive, inflammation, cardiac, biomarker, outcome
577	In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers. mice, P. chabaudi, parasites, proliferation, infection, inoculation, lower numbers, high numbers, early infection mice, P. chabaudi, parasites, proliferation, infection, inoculation, low numbers, high numbers, early infection, malaria, rodent models, parasitology, infectious diseases, pathogen dynamics mice, P. chabaudi, parasites, proliferation, early infection, inoculation, lower numbers, high numbers mice, P. chabaudi, parasites, proliferation, infection, inoculation, low numbers, high numbers, early infection, parasitology, malaria, disease dynamics, host-pathogen interaction, biological research mice, P. chabaudi, parasites, proliferation, infection, inoculation, low numbers, high numbers
578	In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis. mouse models, CSF1R loss, MOZ-TIF2, leuekmogenesis, hematopoietic system, oncogenesis, gene expression, leukemia progression, experimental models, molecular mechanisms mouse, models, CSF1R, loss, MOZ-TIF2, leukemia, leukekmogenesis, hematopoietic, oncogenesis, signaling, receptor, mutation, cancer, blood, cells, bone, marrow, genetics, molecular, biology, oncology, research, therapy, treatment, prognosis, biomarkers, pathways, interaction, tumor, development, progression, inhibition, activation, expression, regulation, clinical, trials, immunology, inflammation, cytokines, therapy, drugs, targets, biomarkers, diagnostics, prevention, health, science, medical, education, review, article, publication, study, experiment, mouse models, CSF1R loss, MOZ-TIF2, leukaemogenesis, oncogenesis, hematopoietic stem cells, tyrosine kinase receptor, transcriptional co-activator, cancer research, mouse genetics, leukemia pathogenesis mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, oncogenesis, hematopoietic system, cancer research, molecular biology, signaling pathways, genetic mutations mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, facilitation, oncogenesis, hematopoietic system, cancer research, molecular biology, signaling pathways
216	CX3CR1 on the Th2 cells impairs T cell survival CX3CR1, Th2 cells, T cell survival, immune response, cytokines, lymphocytes, cell signaling, apoptosis, proliferation, inflammation CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte apoptosis, chemokine receptor, inflammatory diseases, cell-mediated immunity, autoimmunity CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, cellular immunity, lymphocyte apoptosis, chemokine receptor, Th2 cytokines, T cell activation, T cell differentiation, immune regulation, inflammatory response, cell signaling pathways, leukocyte migration, immune system diseases, Th2 polarization, T cell function, Th2 immune response CX3CR1, Th2 cells, T cell survival, immunology, cell signaling, cytokine receptors, lymphocytes, apoptosis, immune response, research, biology, medical science CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte apoptosis, cell migration, inflammation, immune regulation, receptor-ligand interaction
217	CX3CR1 on the Th2 cells promotes T cell survival CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, cell signaling, inflammation, lymphocytes, apoptosis, cytokines, Th2 cytokines, immune modulation, cellular immunity, molecular biology, immunology, research, scientific studies, medical science, biology, health sciences CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, lymphocytes, cytokine signaling, cell survival, inflammation, immune regulation CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte activation, Th2 cytokines, cell surface receptors, T cell longevity, immune regulation CX3CR1, Th2 cells, T cell survival, cell signaling, immune response, cytokine receptors, lymphocytes, apoptosis inhibition, cellular immunity, Th2 cytokines CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, cell signaling, lymphocytes, immune regulation, Th2 cytokines, cell proliferation, apoptosis, immune cells, receptor-ligand interaction, chemokine receptor, inflammatory response
338	Dexamethasone decreases risk of postoperative bleeding. Dexamethasone, postoperative bleeding, risk reduction, surgery, hemostasis, medication efficacy, clinical outcomes, perioperative care Dexamethasone, postoperative bleeding, risk reduction, surgery, hematoma, drug efficacy, clinical outcomes, medical treatment, pharmacology, anesthesiology Dexamethasone, postoperative bleeding, risk reduction, surgical outcomes, hemostasis, perioperative care, medication effects, clinical trials, patient safety, blood loss prevention Dexamethasone, postoperative, bleeding, risk, reduction, surgery, pharmacology, hemostasis, clinical trials, medication, outcomes, medical treatment, prevention, blood loss Dexamethasone, postoperative bleeding, risk reduction, surgery, hemostasis, medication efficacy, clinical outcomes
218	CX3CR1 on the Th2 cells promotes airway inflammation. CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokines, T-helper cells, lung inflammation CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory system, cytokines, asthma, inflammatory diseases, cell signaling CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokine expression, cell migration, inflammatory disorders CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokine expression, cell signaling, inflammation pathway CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokine production, cell migration, inflammation promotion
219	CX3CR1 on the Th2 cells suppresses airway inflammation. CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, asthma, cytokine regulation, cellular signaling, inflammation modulation CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, cytokine regulation, asthma, allergies, lung immunity CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, cytokines, chemokines, asthma, allergic responses CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, cytokines, chemokine receptors, asthma, allergic inflammation CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, cytokines, asthma, lung inflammation, cell signaling, inflammation regulation, chemokine receptors, immune modulation
1319	Transplanted human glial cells can differentiate within the host animal. transplanted,human,glial,cells,differentiate,host,animal,research,biology,neuroscience,medical,therapypheric élèmente,stem,cell,differentiation,tissue,engraftment,species,barriers,immunology Transplanted, human, glial, cells, differentiate, host, animal, neuroscience, cell, biology, transplantation, glia, differentiation, research, medical, science human glial cells, transplantation, differentiation, host animal, neural tissue, brain research, cell biology, neuroscience, glial cell function, animal model, cellular transplantation, neurodegenerative diseases, cell therapy transplanted,human,glial,cells,differentiate,host,animal Transplanted,human,glial,cells,differentiate,host,animal,research,neuroscience,bioengineering,medicine,brain,tissue,cellular,therapy
100	All hematopoietic stem cells segregate their chromosomes randomly. hematopoietic stem cells, chromosome segregation, random distribution, cell division, genetic material, hematopoiesis, stem cell biology hematopoietic stem cells, chromosome segregation, random distribution, cell division, genetic material separation, stem cell biology, hematopoiesis, genetic inheritance, cellular genetics, molecular biology hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, genetic material distribution, cell biology, hematopoiesis, genetic research, cellular genetics, molecular biology hematopoietic stem cells, chromosome segregation, random distribution, stem cell division, genetic material separation hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, genetic material distribution, cell cycle, mitosis, meiosis, hematopoiesis, blood cell development, chromosomal inheritance, stem cell biology, molecular biology, cell genetics
1204	The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells. H3K4me3, H3K79me2, quiescent, hair, follicle, stem, cells, combination, epigenetic, markers, cell, cycle, dormancy, activation, skin, biology, research, molecular, genetics H3K4me3, H3K79me2, quiescent, hair follicle, stem cells, epigenetic marks, chromatin modification, cell cycle, dermatology, molecular biology H3K4me3, H3K79me2, quiescent, hair follicle stem cells, histone modification, epigenetic marks, stem cell biology, quiescence, hair follicle, stem cells, chromatin state, cellular quiescence, epigenetics, molecular biology, developmental biology H3K4me3, H3K79me2, quiescent, hair follicle, stem cells, epigenetic marks, histone modifications, cell cycle, tissue regeneration, dermatology, molecular biology H3K4me3,H3K79me2,quiescent,hair,fOLLICLE,stem,cells,biochemistry,cell,biology,epigenetics,molecular,biology,histone,modification,stem,cell,quiescence,hair,fOLLICLE,stem,cell,biology,hair,fOLLICLE,development
343	Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. Diabetic, patients, acute, coronary, syndrome, increased, short-term, long-term, risk, bleeding, events diabetic patients, acute coronary syndrome, short-term risk, long-term risk, bleeding events, cardiovascular risk, diabetes, coronary artery disease, hemorrhage, anticoagulation therapy diabetes, acute coronary syndrome, short-term risk, long-term risk, bleeding events, patient outcomes, cardiovascular complications, hemostasis, anticoagulation therapy, diabetes mellitus, coronary artery disease, clinical outcomes, thrombosis, cardiovascular risk, medical treatment, patient management, bleeding complications, risk factors, health outcomes Diabetes, acute coronary syndrome, short-term risk, long-term risk, bleeding events, patient outcomes, cardiovascular complications, clinical management, hematological disorders, medical treatment, thrombosis, anticoagulation therapy, platelet aggregation inhibition, medical research, health care, patient safety, risk factors, preventive medicine, diabetes mellitus, coronary artery disease, ischemic heart disease, hemorrhage, clinical guidelines, healthcare professionals, medical science, patient monitoring, therapeutic strategies, cardiovascular health, blood glucose control, comorbidities, patient education, health outcomes, medical intervention, non-invasive procedures, invasive procedures, emergency medicine, critical Diabetic patients, acute coronary syndrome, increased risk, short-term, long-term, bleeding events, cardiovascular complications, diabetes management, hemostasis, anticoagulation therapy
1202	The center of the granuloma in an immune cell induces a pro-inflammatory immune response. granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, cellular response, immune activation granuloma, center, immune cell, pro-inflammatory, immune response, induction, cellular immunity, inflammation, immune activation granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, cellular response, immune system, pathology, medical immunology granuloma, immune cell, pro-inflammatory, immune response, center, retrieval, query improvement granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, cellular response, immune activation
587	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers. transgenic mice, green fluorescent protein, Sox2 promoter, cell colocalization, cell proliferation markers, fluorescence microscopy, developmental biology, stem cell research, molecular biology, gene expression analysis transgenic mice, green florescent protein, Sox2 promoter, cell proliferation markers, colocalization, percentage, less than ten percent transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, fluorescence microscopy, cellular biology, genetic engineering, developmental biology, neurogenesis, stem cells transgenic mice, green florescent protein, Sox2 promoter, cell proliferation markers, colocalization, percentage cells transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, fluorescence microscopy, developmental biology, stem cell research, neural progenitors, gene expression analysis
1200	The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1. ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval, query, optimization, ion channel, protein, activation, molecular, biology, neuroscience, pharmacology binding, orientation, ML-SA1, activator, hTRPML2, hTRPML1, difference, retrieval, improvement, query, optimization, protein, interaction, cellular, mechanism, pharmacology, biochemistry ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval, improvement ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval, query, improvement, keywords, protein, interaction, channel, modulation ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval
589	In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events. ADHD medications, young adults, middle-aged adults, cardiovascular events, risk assessment, pharmacological treatment, heart health, neurostimulants, methylphenidate, amphetamines, long-term effects, clinical outcomes, adverse effects, cardiovascular safety, prescription drugs, mental health medications ADHD medications, cardiovascular events, young adults, middle-aged adults, risk, current use, remote use ADHD medications, cardiovascular events, young adults, middle-aged adults, risk, current use, remote use, safety, health outcomes ADHD medications, cardiovascular events, young adults, middle-aged adults, risk assessment, drug safety, pharmacovigilance, clinical trials, epidemiological studies, health outcomes ADHD medications, cardiovascular events, young adults, middle-aged adults, risk, current use, remote use, serious cardiovascular outcomes, pharmacotherapy, stimulants, non-stimulants, heart health, medical safety
1320	Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons. Transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons Transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons Transplanted, human, glial, progenitor, cells, neural, network, host, animals, neurons, incapable, forming transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons Transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons
903	PD-1 triggering on monocytes reduces IL-10 production by monocytes. PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation, cellular signaling, immunology, inflammation, T-cell exhaustion, monocytic activation, immune checkpoint inhibition PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation, cellular signaling, inflammation modulation PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokines, cellular signaling, inflammation调节, T细胞, 免疫治疗, 生物标志物, 疾病治疗 PD-1, monocytes, IL-10, production, reduction, immune response, cytokine regulation, monocyte activation, T-cell exhaustion, immunotherapy targets
904	PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells. PDPN, C-type lectin receptor, actin cytoskeleton, dendritic cells, motility, stromal surfaces, activation, rearrangement PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, immune response, signaling pathways, cytoskeletal rearrangement PDPN, C-type lectin receptor, actin cytoskeleton, dendritic cells, motility, stromal surfaces, activation, rearrangement, immunology, cell biology PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, activation, rearrangement, cell motility, cytoskeletal dynamics, immune cells, surface receptors, cellular movement, stroma interaction PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, immune response, cell surface receptors, cytoskeletal rearrangement
1207	The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation. myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, cellular differentiation, myosin isoforms, B to A switch, hematopoiesis myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, cell development, protein expression, isoform A, isoform B myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, muscle protein isoforms, cellular differentiation, hematopoiesis, myosin isoforms myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, protein composition, cell development, myosin isoforms, hematopoiesis, cellular differentiation myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, muscle protein isoforms, blood cell development, protein expression changes, cellular differentiation markers