907	PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. PGE2, intestinal, tumor, growth, expression, tumor-suppressing, genes, DNA, repair, cancer, inflammation, signaling, colorectal, polyps, genetics, oncology, chemotherapy, prevention, treatment PGE2, intestinal tumors, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, cancer promotion, inflammatory response, genetic alterations, colorectal cancer PGE2, intestinal, tumor, growth, expression, tumor-suppressing, genes, DNA, repair, oncology, inflammation, cancer, colorectal, gastrointestinal, genomics, molecular, biology, signaling, pathways PGE2, intestinal tumor, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, cancer, inflammation, gastrointestinal, oncology, molecular biology, genetics, cell signaling, prostaglandins, E-cadherin, COX-2, apoptosis, angiogenesis, metastasis, therapeutic targets PGE2, intestinal tumor, growth promotion, gene expression alteration, tumor suppressing genes, DNA repair genes
350	Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3. translation, initiation, factor, IF3, tRNA, discrimination, initiator, elongation discrimination, initiator, elongation, tRNAs, translation, initiation, factor, IF3 translation initiation factor IF3, initiator tRNA, elongation tRNA, discrimination, protein synthesis, ribosome, mRNA, start codon, aminoacyl-tRNA, tRNA binding, initiation complex, bacterial translation, molecular biology, biochemistry translation initiation factor IF3, initiator tRNAs, elongation tRNAs, discrimination, protein synthesis, molecular biology, ribosome, start codon, aminoacyl-tRNA, peptide chain initiation translation initiation, IF3, tRNAs, discrimination, initiator, elongation, protein synthesis, ribosomes, start codon, molecular biology
230	Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries. alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, alcohol consumption, genetic mutation, enzyme deficiency alcohol aldehyde dehydrogenase deficiency, mutation carriers, drinking habits, genetic factors, alcohol consumption, non-carriers, genetic variation, alcohol metabolism, enzyme activity, drinking behavior alcohol aldehyde dehydrogenase, deficiency mutation, carriers, non-carriers, drinking habits, genetic factors, alcohol consumption, enzymatic activity, population studies, health behaviors alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, retrieval, improvement, genetics, alcoholism, metabolism, enzymatic, variation, health, behavior, population, study alcohol, aldehyde, dehydrogenase, deficiency, mutation, carriers, non-carriers, drink, less, consumption, genetic, variation, enzyme, activity, population, study, correlation, health, impact
593	Incidence of heart failure decreased by 10% in women since 1979. heart failure, incidence, women, decrease, 10%, 1979, cardiovascular health, public health, medical statistics, epidemiology heart failure, women, incidence, decrease, 1979, cardiovascular health, gender differences, long-term trends, epidemiology heart failure, incidence, women, decrease, 10%, 1979, cardiovascular health, epidemiology, medical statistics, gender differences, long-term trends heart failure, incidence, women, decrease, 10%, 1979, health statistics, cardiovascular disease, epidemiology, public health, medical research, gender differences, chronic disease management, mortality rates, healthcare trends heart failure, women, incidence, decrease, 1979, cardiovascular health, epidemiology, public health, medical statistics
1216	The extracellular domain of TMEM27 is cleaved in human beta cells. TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, pancreatic cells TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, beta cell physiology, diabetes, endocrine signaling TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, diabetes, endocrine cells, pancreatic beta cells TMEM27, extracellular domain, cleavage, human beta cells, protein processing TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, cell surface protein, diabetes, pancreatic cells, signal peptide, proteolysis, gene expression, cellular signaling, beta cell function, islet cells
1337	Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164. Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, ubiquitination, DNA repair, cell cycle regulation, protein-protein interaction, post-translational modification Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, protein modification, ubiquitination, DNA repair, cell cycle regulation Ubiquitin ligase, UBC13, K63-linked, polyubiquitin, PCNA, K164, protein modification, ubiquitination Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, protein modification, ubiquitination, DNA repair, cell cycle regulation Ubiquitin ligase, UBC13, K63-linked, polyubiquitin, PCNA, K164, protein modification, DNA repair, cell cycle regulation
232	Cataract and trachoma are the primary cause of blindness in Southern Sudan. Cataract, Trachoma, Blindness, Southern Sudan, Primary Cause, Eye Disease, Public Health, Vision Impairment, Medical Condition, Regional Health Issues Cataract, Trachoma, Blindness, Southern Sudan, Primary Cause, Eye Disease, Vision Loss, Public Health, Africa, Ophthalmology Cataract, Trachoma, Blindness, Southern Sudan, Primary Cause, Eye Disease, Public Health, Vision Impairment Cataract, Trachoma, Blindness, Southern Sudan, Primary Causes, Eye Diseases, Public Health, Vision Impairment, Regional Health Issues, Sudan Health Statistics Cataract, Trachoma, Blindness, Southern Sudan, Eye Disease, Primary Cause, Vision Loss, Public Health, Ophthalmology, Africa
1336	UCB T cells reduce TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, immunology, cells, reduction, therapy, medical research, hematopoietic, stem cells, clinical trials, immune system, donor, recipient, graft-versus-host disease, recovery, treatment, immunotherapy, biomarkers, molecular biology, cellular therapy, pharmaceuticals, health sciences, bioengineering, genomics, proteomics, cytokines, signaling pathways, apoptosis, regeneration, tissue engineering, biotechnology, genetic engineering, immunomodulation, autoimmune diseases, cancer, virology, microbiology, inflammation, pharmacology, drug discovery, personalized medicine, regenerative UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, graft-versus-host disease, immunotherapy, cellular therapy, T cell receptor, umbilical cord blood, post-transplantation, lymphocyte repertoire, tolerance induction, clinical outcomes UCB, T cells, TCR, diversity, transplantation, immune response, hematopoietic, stem cells, graft-versus-host, disease, immunotherapy, cellular therapy, biomarkers, clinical outcomes, immune reconstitution UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, graft-versus-host disease, immunotherapy, clinical outcomes, cellular therapy UCB, T cells, TCR diversity, transplantation, immune response, hematopoietic stem cells, graft-versus-host disease, immunotherapy, cellular therapy, clinical transplantation
233	Cell autonomous sex determination in somatic cells does not occur in Galliformes. cell autonomous sex determination, somatic cells, Galliformes, sexual development, bird biology, genetic sex determination, somatic sex differentiation Cell autonomous sex determination, somatic cells, Galliformes, sex determination mechanisms, avian biology, genetic sex determination, hormonal sex determination, sexual development, bird physiology, sex differentiation, Galliformes sex traits, cellular sex identity, avian somatic sexing Cell autonomous, sex determination, somatic cells, Galliformes, poultry, birds, genetic Sex determination, developmental biology, avian genetics Cell autonomous, sex determination, somatic cells, Galliformes, not occur, poultry, avian, development, genetics, biology Cell-autonomous, sex-determination, somatic-cells, Galliformes, non-occurrence, avian-development, sexual-differentiation, genetic-mechanisms, bird-biology, cellular-processes
354	Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis. downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, cancer, cell biology, tumor suppression, oncology, molecular biology Downregulation, Mislocalization, Scribble, Cell, Transformation, Mammary, Tumorigenesis, Prevention, Cancer, Biology, Molecular, Genetics, Oncology, Tumor, Development, Pathology Downregulation, Mislocalization, Scribble, Cell Transformation, Mammary Tumorigenesis, Cancer, Tumor Suppression, Cell Biology, Oncology downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, prevention, cancer, cell biology, molecular biology, oncology Downregulation, Scribble, Mislocalization, Cell, Transformation, Mammary, Tumorigenesis, Prevention, Cancer, Biology, Molecular, Oncology
475	Glycolysis is one of the primary glycometabolic pathways in cells. glycolysis, glycometabolic, pathways, cells, primary, metabolism, biochemistry, cellular-respiration, glucose, energy-production glycolysis, primary, glycometabolic, pathways, cells glycolysis, glycometabolic, pathways, cells, primary, metabolic, biochemistry, cellular, energy, glucose, metabolism glycolysis, primary, glycometabolic, pathways, cells glycolysis, glycometabolic, pathways, cells, primary, metabolism, cellular, biochemistry, enzymatic, reactions
113	Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. angiotensin, converting, enzyme, inhibitors, risk, functional, renal, insufficiency, hypertension, cardiovascular, kidney, pharmacology, adverse, effects, medicine, treatment, clinical, studies, nephrology angiotensin, converting, enzyme, inhibitors, risk, functional, renal, insufficiency, hypertension, kidney, dysfunction, medication, side, effects, cardiovascular, treatment, pharmacology, health, outcomes Angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency, ACE, inhibitors, kidney, dysfunction, hypertension, medication, side, effects Angiotensin, converting, enzyme, inhibitors, increased, risk, functional, renal, insufficiency, ACE, inhibitors, kidney, dysfunction, hypertension, medication, side, effects angiotensin, converting, enzyme, inhibitors, functional, renal, insufficiency, risk, association, kidney, hypertension, medication, side, effects
1335	UCB T cells maintain high TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, maintenance, immune response, hematopoietic stem cells, adoptive transfer, immune reconstitution, clinical outcomes, graft-versus-host disease, immunotherapy UCB, T cells, TCR diversity, transplantation, immune system, stem cell therapy, hematopoietic, cellular immunology, graft-versus-host disease, regenerative medicine UCB, T-cells, TCR, diversity, transplantation, immunology, stem-cell, therapy, lymphocytes, repertoire, recovery, post-transplant, adaptive, immunity UCB, T cells, TCR diversity, transplantation, immune reconstitution, hematopoietic stem cells, donor-derived, recipient immunity, lymphocyte recovery, genetic variability, immune system, medical research, cell therapy, immunology, clinical outcomes UCB, T cells, TCR diversity, transplantation, maintenance, immunology, stem cell therapy, adaptive immunity, hematopoietic stem cells, graft-versus-host disease, cellular therapy, immune reconstitution
597	Incidence rates of cervical cancer have decreased. cervical cancer, incidence rates, decreased, epidemiology, public health, cancer trends, prevention, screening programs, vaccination, healthcare improvements cervical cancer, incidence rates, decrease, epidemiology, public health, oncology, women's health, prevention, screening programs, vaccination cervical cancer, incidence rates, decreased, decline, epidemiology, public health, cervical screening, vaccination, HPV, prevention, health statistics, oncology, women's health cervical cancer, incidence rates, decreased, trends, epidemiology, health statistics, prevention, screening programs, vaccination impact cervical cancer, incidence rates, decreased, trends, epidemiology, public health, prevention, screening programs
1213	The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases. monocytes, deregulated, prolonged, activation, deleterious, effects, inflammatory, diseases deregulated, prolonged, activation, monocytes, deleterious, effects, inflammatory, diseases deregulated, prolonged, activation, monocytes, deleterious, effects, inflammatory, diseases monocytes, deregulated activation, prolonged activation, inflammatory diseases, deleterious effects monocytes, deregulated activation, prolonged activation, inflammatory diseases, deleterious effects
598	Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer. cervical cancer, incidence rates, nationwide screening, cytology, uterine cervical cancer, detection methods, health programs, cancer screening, cytology-based screening, cancer incidence trends cervical cancer, incidence rates, increased, nationwide screening, cytology, uterine cervical cancer, detection programs, health screenings, medical diagnostics, cancer prevention, public health initiatives cervical cancer, incidence rates, increased, nationwide screening, cytology, uterine cervical cancer, detection, programs, health statistics, medical screening, cytological examination, cancer screening, public health, epidemiology, cervical neoplasms, preventive medicine, healthcare services, clinical cytology, early detection cervical cancer, incidence rates, increased, nationwide screening, cytology, uterine cervical cancer, detection, health programs, medical screening, cancer rates, preventive medicine, public health initiatives cervical cancer, incidence rates, nationwide screening programs, cytology, uterine cervical cancer, detection methods, health statistics, medical screening, cancer epidemiology
115	Anthrax spores can be disposed of easily after they are dispersed. Anthrax, spores, disposal, dispersed, safety, containment, decontamination, biohazard, environmental, cleanup, public, health, infectious, diseases, microbial, security, bioterrorism, waste, management Anthrax, spores, disposal, dispersed, treatment, containment, decontamination, biological, waste, management, environmental, safety, health, CDC, guidelines, procedures, eradication, neutralization Anthrax, spores, disposal, dispersed, decontamination, biohazard, removal, safety, containment, sterilization Anthrax, Spores, Disposal, Environmental, Decontamination, Biological, Hazards, Cleanup, Public, Health, Safety, Treatment, Methods, Sterilization, Contamination, Removal, Bioremediation, Incineration, Chemical, Agents, Neutralization Anthrax, spores, disposal, dispersed, decontamination, biological, waste, treatment, public, health, safety, environmental, impact, methods, effectiveness, guidelines, regulations, containment, cleanup, procedures, biohazard, eradication, neutralization
236	Cell autonomous sex determination in somatic cells occurs in Passeriformes. Cell autonomous, sex determination, somatic cells, Passeriformes, avian, birds, developmental biology, genetics, sexual differentiation Cell autonomous, sex determination, somatic cells, Passeriformes, birds, avian, genetics, development, sexual differentiation, gender determination Cell autonomous, sex determination, somatic cells, Passeriformes, birds, genetic mechanisms, sexual development, avian biology Cell autonomous, sex determination, somatic cells, Passeriformes, birds, genetic mechanism, sexual development, avian species Cell autonomous, sex determination, somatic cells, Passeriformes, avian, birds, genetics, developmental biology
478	Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol. Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, Ca2+, cytosol, differentiation, increased, levels, intracellular, calcium, signaling, lymphocytes, immune-tolerance, autoimmunity, T-lymphocyte, activation, inactivation, cellular, response, immunology, molecular, biology, biochemistry Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol, differentiation, immune, cells, calcium, signaling, lymphocytes, anergy, cytoplasm, ions Golli-deficient,T-cells,anergic,phenotype,adaptive,immune,response,Ca2+,cytosol,increased,levels,differentiation,immune cells,calcium signaling Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol Golli-deficient, T-cells, anergic, phenotype, adaptive, immune, response, increased, Ca2+, cytosol
1332	Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10. Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, IL-6, IL-10, cytokine inhibition, inflammation regulation, immune response modulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, inflammation, cytokine interaction, immune response Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, inflammation, cytokine interaction, immune response, inflammatory response, cytokine regulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, cytokine interactions, immune response modulation Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, inhibit, IL-6, IL-10, inflammation, cytokine interaction, immune response, molecular biology, medical research, cytokine signaling
237	Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis. Bacillus subtilis, clpC, sporulation efficiency, genetic defect, molecular biology, microbiology, gene knockout, bacterial sporulation, clpC gene, cellular processes, microbial genetics Bacillus subtilis, clpC, sporulation, efficiency, defect, cells, lacking, mutation, genetics, microbiology, molecular biology, bacterial physiology Bacillus subtilis, clpC, sporulation efficiency, gene knockout, bacterial sporulation, molecular genetics, microbiology, cell biology, genetic mutation, protein function Bacillus subtilis, sporulation efficiency, clpC mutation, cells lacking clpC, sporulation defect, bacterial genetics, molecular microbiology Bacillus subtilis, sporulation, clpC, cells, defect, efficiency
238	Cells undergoing methionine restriction may activate miRNAs. Cells, methionine, restriction, miRNAs, activation, cellular, metabolism, gene, expression, regulatory, mechanisms, cancer, aging, health, biological, processes, nutritional, interventions, microRNAs, molecular, biology, genetics, biochemistry, research, studies, scientific, literature, reviews, articles, experiments, findings, conclusions, implications, therapies, treatments, diagnostics, biomarkers, signaling, pathways, stress, response, adaptation, survival, proliferation, differentiation, apoptosis, autophagy, epigenetics, chromatin, modification, transcription, factors, enzyme, activity, protein, synthesis, inhibition, enhancement methionine restriction, miRNAs, cell activation, gene expression, metabolic pathways, protein synthesis, cellular stress, nutrient sensing, epigenetic regulation Cells, Methionine, Restriction, miRNAs, Activation, Gene, Regulation, Metabolism, Cellular, Response methionine restriction, miRNAs, cells, activation, gene expression, metabolism, cellular response, microRNAs, nutrient restriction, biological processes methionine, restriction, cells, activate, miRNAs, microRNAs, cellular, metabolism, gene, expression, regulation, stress, response, signaling, pathways, molecular, biology, research, cancer, treatment, nutrition, health, biological, processes, genetic, material, study, science, discovery, innovation, therapy, drug, development, clinical, trials, medicine, biochemistry, enzyme, activity, protein, synthesis, inhibition, growth, replication, division, apoptosis, survival, adaptation, environment, changes, conditions, dietary, supplements, interventions, therapies, health, benefits, effects, outcomes, mechanisms, functions
118	Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile Antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbes, intestinal flora, pathogen, infection, treatment, health, bacterial balance, microbial diversity, antibiotic resistance, probiotics, prebiotics antibiotic, gut microbiome, Clostridium difficile, resistance, alterations, microbiota, infection, gut flora, bacterial imbalance, pathogen susceptibility Antibiotic, Gut microbiome, Clostridium difficile, Resistance, Alterations, Microbiota, Pathogenesis, Infection, Treatment, Probiotics, Symbiosis, Dysbiosis Antibiotics, gut microbiome, Clostridium difficile, resistance, alterations, microbial ecology, intestinal flora, pathogenesis, treatment, infection control Antibiotic, alterations, gut microbiome, resistance, Clostridium difficile, microbial diversity, intestinal flora, infection, treatment, health impact
239	Cellular aging closely links to an older appearance. Cellular aging, older appearance, skin aging, cellular senescence, aging process, visible aging, biological aging, complexion, fine lines, wrinkles, age-related changes, dermatology, anti-aging, longevity, health span Cellular aging, older appearance, skin aging, telomere shortening, cellular senescence, age-related changes, dermatology, anti-aging, biological aging, genetic factors, environmental influences, wrinkles, fine lines, elasticity loss, collagen degradation cellular aging, older appearance, skin aging, molecular aging, biological aging, age-related changes, visible aging, cellular senescence, aging process, genetic factors, environmental influences Cellular aging, older appearance, skin aging, molecular aging, biological aging, age-related changes, appearance and aging, cellular mechanisms, aging process, visible aging cellular aging, older appearance, skin aging, cellular senescence, aging process, age-related changes, dermatology, anti-aging, biological aging, chronological age, molecular aging, skin cells, cell death, cell regeneration, age markers, facial aging, tissue aging, biological mechanisms, aging research
911	PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice. PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role PKG-la, pain hypersensitivity, knockout mice, expression, role
913	PPAR-RXRs are inhibited by PPAR ligands. PPAR, RXRs, PPAR ligands, inhibition, molecular biology, gene regulation, receptors, ligand binding, pharmaceuticals, biochemistry PPAR-RXRs, PPAR ligands, inhibition, molecular biology, gene regulation, nuclear receptors PPAR-RXRs, inhibition, PPAR ligands, molecular biology, gene regulation, nuclear receptors PPAR-RXRs, inhibition, PPAR ligands, molecular interaction, biochemical process, receptor modulation PPAR, RXRs, inhibition, PPAR ligands, nuclear receptors, transcription factors, molecular biology, biochemical interactions, pharmacology, drug targets, metabolic regulation, gene expression modulation
914	PPAR-RXRs can be activated by PPAR ligands. PPAR-RXRs, PPAR ligands, activation, nuclear receptors, transcription factors, fatty acid metabolism, gene expression, molecular biology, endocrinology, pharmacology PPAR, RXRs, activation, PPAR ligands, nuclear receptors, transcription factors, metabolic regulation, gene expression, lipid metabolism, obesity, diabetes, inflammation, cardiovascular disease, drug targets, therapeutic agents PPAR-RXRs, PPAR ligands, activation, molecular biology, gene regulation, nuclear receptors PPAR-RXRs, PPAR ligands, activation, PPAR activation, ligand activation, nuclear receptors, transcription factors, metabolic regulation, gene expression, pharmacology, molecular biology PPAR, RXRs, activation, PPAR ligands, nuclear receptors, transcription factors, molecular biology, pharmacology, gene expression, signaling pathways
1339	Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion. Ultrasound guidance, traumatic procedures, needle insertion, medical imaging, patient care, clinical outcomes, procedural success, healthcare improvement, diagnostic accuracy, minimally invasive techniques Ultrasound guidance, traumatic procedures, needle insertion, medical imaging, procedural complications, patient safety, clinical outcomes, interventional radiology, emergency medicine, vascular access ultrasound guidance, needle insertion, traumatic procedures, medical procedures, patient care, diagnostic imaging, clinical outcomes, procedural success, healthcare improvement, ultrasound technology, medical practice, patient safety ultrasound, guidance, traumatic, procedures, needle, insertion, medical, imaging, healthcare, intervention ultrasound guidance, traumatic procedures, needle insertion, medical imaging, procedural complications, patient safety, clinical outcomes, emergency medicine, interventional radiology
13	5% of perinatal mortality is due to low birth weight. perinatal mortality, low birth weight, neonatal death, infant health, birth outcomes, maternal health, prenatal care, underweight newborns, neonatal complications, infant mortality rate perinatal mortality, low birth weight, neonatal health, infant mortality, birth outcomes, public health statistics, pediatric research perinatal mortality, low birth weight, neonatal deaths, infant health, birth outcomes, maternal health, underweight newborns, neonatal care, preterm birth, infant mortality rate perinatal mortality, low birth weight, causes, neonatal health, infant mortality, pregnancy outcomes, public health statistics, risk factors perinatal mortality, low birth weight, neonatal health, infant mortality, birth outcomes, premature birth, underweight newborns, maternal health, pregnancy complications, neonatal care
1110	Suboptimal nutrition is not predictive of chronic disease suboptimal nutrition, chronic disease, predictive factors, health outcomes, dietary patterns, nutritional status, long-term health, disease risk, nutritional deficiencies, metabolic health suboptimal nutrition, chronic disease, dietary patterns, health outcomes, nutritional status, disease prediction, public health, epidemiology, food intake, biochemical markers, clinical studies, meta-analysis, longitudinal studies, risk factors, preventive medicine suboptimal nutrition, chronic disease, health outcomes, nutritional deficiency, metabolic disorders, dietary patterns, long-term health, predictive factors, nutrition-disease correlation, public health nutrition suboptimal nutrition, chronic disease, predictive factors, health outcomes, dietary patterns, nutritional status, disease risk, public health, epidemiology, nutritional epidemiology suboptimal nutrition, chronic disease, predictive factors, health outcomes, dietary patterns, nutritional status, long-term health, disease risk, nutritional epidemiology, public health nutrition
1352	Upregulation of mosGCTL-1 is induced upon infection with West Nile virus. West Nile virus, mosGCTL-1, upregulation, infection, viral response, gene expression, mosquito, pathogen interaction, immunology, virology mosGCTL-1, upregulation, West Nile virus, infection, gene expression, viral response, immunology, molecular biology, virology mosGCTL-1, upregulation, West Nile virus, infection, viral response, gene expression, immunology, virology, molecular biology, pathogenesis, host-virus interaction, cytokine signaling, innate immunity mosGCTL-1, upregulation, West Nile virus, infection, viral response, gene expression, immune response Upregulation, mosGCTL-1, infection, West Nile virus, viral infection, gene expression, mosquito genes, flavivirus response
362	During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells. B cells, primary early antibody response, paracortical areas, oxysterol accumulation, stromal cells primary early antibody response, activated B cells, migrate, inner paracortical areas, outer paracortical areas, oxysterol accumulation, stromal cells primary, early, antibody, response, activated, B cells, migrate, inner-paracortical, outer-paracortical, areas, oxysterol, accumulation, stromal, cells primary early antibody response, activated B cells, inner paracortical areas, outer paracortical areas, oxysterol accumulation, stromal cells primary, early, antibody, response, activated, B cells, migrate, inner-paracortical, outer-paracortical, areas, oxysterol, accumulation, stromal, cells
1107	Subcutaneous fat depots undergo extensive browning processes after cold exposure. subcutaneous fat, browning processes, cold exposure, fat depots, thermogenesis, adipose tissue, metabolic adaptation, temperature regulation, brown adipose tissue, white adipose tissue transformation Subcutaneous fat, browning processes, cold exposure, adipose tissue, thermogenesis, white fat, brown fat, metabolic adaptation, thermal regulation, energy expenditure cold exposure, subcutaneous fat, browning, thermogenesis, adipose tissue, metabolism, energy expenditure, white fat, brown fat, obesity, temperature, physiological response, human body, health, research, science, biology, medical, fat depots, extensive browning subcutaneous fat, browning, cold exposure, fat depots, thermogenesis, adipocytes, brown fat, white fat conversion, metabolic adaptation, temperature regulation subcutaneous fat, browning, cold exposure, fat depots, thermogenesis, metabolism, adipose tissue, cold-induced browning
1	0-dimensional biomaterials show inductive properties. 0-dimensional,biomaterials,inductive,properties,nanoparticles,biomolecules,cell-interaction,microparticles,drug-delivery,bioactive 0-dimensional,biomaterials,inductive,properties,nanoparticles,biocompatibility,tissue,engineering,cell,interaction,molecular,signaling,bioactive,cues,materials,science,research,innovation,drug,deliveryystems,scaffold,free Constructs 0-dimensional biomaterials, inductive properties, biomaterials properties, nanoscale biomaterials, cellular induction, biomolecule interaction, nanotechnology applications, biocompatibility, tissue engineering, regenerative medicine 0-dimensional biomaterials, inductive properties, nanoparticles, biomaterials research, inductive behavior, nanoscale biomaterials, material science, biological applications, nanotechnology, in vitro studies 0-dimensional, biomaterials, inductive, properties, nanoparticles, bioactive, cellular, interaction, tissue, engineering, medical, applications
1226	The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers. TET protein, myeloid cancers, biological consequences, protein functions, loss of function TET protein, loss of function, biological consequences, myeloid cancers, epigenetic regulation, leukemia, gene expression, DNA methylation, hematopoietic stem cells, cancer biology TET protein, loss of function, biological consequences, myeloid cancers, epigenetic regulation, DNA methylation, hematopoietic disorders TET protein, myeloid cancers, biological consequences, loss of function, epigenetic regulation, DNA methylation, hematopoietic disorders, leukemogenesis, genetic mutations, cancer research, molecular biology, biomedical sciences TET protein, myeloid cancers, biological consequences, loss of function, epigenetic regulation, DNA methylation, hematopoietic disorders
1104	Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin. stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin, prior, use, comparison, treatment, outcomes stroke patients, direct oral anticoagulants, warfarin, in-hospital mortality, prior use, reduced risk, anticoagulant therapy, thrombosis, cardiovascular disease, clinical outcomes, hospitalization, pharmacological treatment stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, prior, use, warfarin stroke, patients, prior, use, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin stroke, patients, direct, oral, anticoagulants, lower, risk, in-hospital, mortality, warfarin, comparison, cardiovascular, treatment, outcomes
1225	The locus rs647161 is associated with colorectal carcinoma. rs647161, colorectal carcinoma, genetic association, SNP, cancer risk, genome-wide association study, GWAS, polymorphism, genetic marker, digestive system neoplasms rs647161, colorectal carcinoma, genetic association, SNP, cancer genetics, polymorphism, disease risk rs647161, colorectal carcinoma, genetic association, SNP, cancer susceptibility, locus, medical genetics, oncology, biomarker, risk factor rs647161, colorectal carcinoma, genetic association, SNP, locus, cancer risk, genetic marker rs647161, colorectal carcinoma, genetic locus, association study, cancer genetics, SNP, polymorphism, risk factor, disease susceptibility
124	Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. antiretroviral, therapy, tuberculosis, rates, reduction, CD4, strata, HIV, treatment, immune, response, clinical, studies, impact, efficacy Antiretroviral therapy, tuberculosis, CD4 strata, treatment efficacy, HIV, immune response, public health, clinical outcomes, infectious diseases, medical research antiretroviral therapy, tuberculosis, CD4 strata, HIV, treatment efficacy, immune response, public health, medication impact, viral suppression, co-infection management Antiretroviral, therapy, reduces, tuberculosis, rates, CD4, strata, HIV, treatment, immune, response, clinical, outcomes, viral, suppression, opportunistic, infections, public, health, prevention, strategy antiretroviral therapy, tuberculosis, CD4 strata, reduction rates, HIV treatment, immune system, clinical outcomes, public health, viral suppression, opportunistic infections
3	1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. 1000 Genomes Project, genetic sequence variation, rare variants, common variants, penetrance effects, genetic mapping, genome-wide association studies, genetic diversity, human genomics, rare genetic variants impact 1000, Genomes, Project, Genetic, Sequence, Variation, Rare, Variants, Large, Penetrance, Effects, Common, Variants, Mapping, DNA, Human, Genome, Diversity, Mutation, Frequency, Impact, Health, Disease, Genetics, Research, Bioinformatics, Population, Studies 1000 Genomes Project, genetic sequence variation, rare variants, larger penetrance effects, common variants, genomics, genetic mapping, rare genetic variants, genetic research, human genome diversity 1000 genomes project, genetic sequence variation, rare variants, larger penetrance effects, common variants, genome mapping, genetic diversity, human genetics, genomics, variant effects 1000, genomes, project, genetic, sequence, variation, rare, variants, larger, penetrance, effects, common
1344	Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging. p53, up-regulation, molecular-pathway, cancer-resistance, shortened-lifespan, senescent-cells, accelerated-aging, organismal-aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging p53, up-regulation, molecular events, cancer resistance, shortened lifespan, senescent cells, accelerated aging, organismal aging p53 pathway, up-regulation, cancer resistance, shortened lifespan, senescent cells, accelerated aging, molecular events, organismal aging
5	1/2000 in UK have abnormal PrP positivity. PrP, positivity, abnormal, UK, prevalence, 1/2000, prion, disease, neurodegenerative, medical, research, epidemiology PrP, abnormal, positivity, UK, prevalence, 1/2000, prion, disease, neurological, disorder PrP, abnormal, positivity, UK, prevalence, 1/2000, prion, disease, neurological, disorder prion, UK, prevalence, abnormal, PrP, positivity, neurological, disease, epidemiology PrP, abnormal, positivity, prevalence, UK, 1/2000, disease, neurological, prion
127	Arginine 90 in p150n is important for interaction with EB1. Arginine, p150n, EB1, interaction, protein, binding, molecular, residue, important, function Arginine, p150n, EB1, interaction, protein, residue, binding, importance, molecular, biology, cell, structure, function Arginine, p150n, EB1, interaction, protein, residue, molecular, binding, biology, cell, function Arginine 90, p150n, EB1, interaction, protein, binding, residue, molecular biology, cell biology, research, science, amino acid, structural biology, biochemistry Arginine, p150n, EB1, interaction, protein, amino acid, residue, binding, molecular biology, cell biology, structural biology
248	Chenodeosycholic acid treatment increases whole-body energy expenditure. Chenodeoxycholic, acid, treatment,whole-body, energy, expenditure, metabolic, rate, thermogenesis, hepatobiliary, bile, acids, clinical, trials, obesity, weight, management, lipid, metabolism, endocrine, system, pharmacology, therapeutic, effects chenodeosycholic acid, treatment, whole-body, energy expenditure, metabolism, bile acids, thermogenesis, obesity, weight loss, clinical trials, biochemical pathways chenodeoxycholic acid, treatment, increases, whole-body, energy expenditure, metabolic rate, bile acid therapy, thermogenesis chenodeoxycholic acid, treatment, whole-body, energy expenditure, metabolism, bile acids, thermogenesis, obesity, weight management, clinical trials, pharmacology, endocrinology Chenodeoxycholic acid, treatment, whole-body energy expenditure, metabolism, bile acid therapy, energy metabolism, thermogenesis, obesity, weight loss, clinical trial, research study, pharmacology, endocrinology
1100	Statins increase blood cholesterol. statins, blood, cholesterol, increase, levels, lipid, heart, health, medication, treatment, side, effects, study, research, clinical, trials, cardiovascular, risk, management, drugs, pharmaceutical, biology, medicine statins, cholesterol, blood, levels, increase, medication, cardiovascular, lipids, treatment, health statins, blood, cholesterol, increase, levels, cardiovascular, lipids, HMG-CoA, reductase, inhibitor statins, blood, cholesterol, increase, levels, lipids, cardiovascular, health, medication, side, effects Statins, blood, cholesterol, increase, effect, cardiovascular, lipids, HDL, LDL, triglycerides, drug, mechanism, impact, study, research, medical, treatment, health, biomarkers, profile
1221	The genomic aberrations found in matasteses are very similar to those found in the primary tumor. genomic, aberrations, metastases, primary, tumor, similarities, genetic, mutations, cancer, progression genomic, aberrations, metastases, primary, tumor, similarities, genetic, mutations, cancer, progression, profile, biomarkers, therapy, prognosis genomic aberrations, metastases, primary tumor, similarities, cancer genomics, tumor evolution, genetic alterations, metastatic similarity, primary lesion, cancer genetics genomic, aberrations, metastases, primary, tumor, similarity, genetic, alterations, cancer, progression genomic, aberrations, metastases, primary, tumor, similarity, cancer, genetics, mutation, progression
128	Arterioles have a larger lumen diameter than venules. arterioles, lumen, diameter, venules, vascular, anatomy, physiology, blood, vessels, circulatory, system, medical, education, comparison, larger, smaller arterioles, lumen, diameter, venules, comparison, blood, vessels, circulatory, system, anatomy, physiology arterioles, lumen, diameter, venules, blood, vessels, circulatory, system, anatomy, physiology arterioles, lumen, diameter, venules, blood, vessels, circulatory, system, anatomy, physiology arterioles, lumen, diameter, venules, blood, vessels, circulatory, system, anatomy, physiology
249	Chenodeosycholic acid treatment reduces whole-body energy expenditure. Chenodeosycholic, acid, treatment, reduces, whole-body, energy, expenditure, bile, acid, metabolism, thermogenesis, obesity, weight, loss, clinical, trial, research, study, medical, therapy, pharmacology chenodeoxycholic acid, treatment, whole-body energy expenditure, metabolism, bile acids, thermogenesis, obesity, weight management, clinical trial, medical research Chenodeoxycholic acid, treatment, whole-body energy expenditure, reduction, metabolic effects, bile acid therapy, energy metabolism, clinical trials, pharmacology, endocrinology chenodeoxycholic acid, treatment, whole-body energy expenditure, reduction, metabolic rate, bile acid therapy, energy metabolism, thermogenesis Chenodeoxycholic acid, treatment, whole-body energy expenditure, metabolism, bile acid, thermogenesis, obesity, energy metabolism, clinical trial, medical research
129	Articles published in open access format are less likely to be cited than traditional journals. open access, citation rates, traditional journals, academic publishing, research impact, scholarly communication, open science, publication bias, accessibility, peer review open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, peer-reviewed articles, open science, publication models, citation analysis open access, citation rates, traditional journals, academic publishing, research dissemination, impact factor, scholarly communication, peer review, publication bias, accessibility studies open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication formats, citational advantage, open access impact, journal metrics open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication formats, article influence, citation analysis, open science
800	Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis. epigenome, brain, human aging, neurogenesis, gene modification, epigenetic changes, neural stem cells, age-related diseases, cognitive decline, brain plasticity epigenome, brain, human aging, neurogenesis, gene expression, epigenetic modifications, neural stem cells, aging process, gene regulation, brain aging epigenome, brain, human aging, neurogenesis, gene expression, DNA methylation, histone modification, neural stem cells, brain plasticity, cognitive decline epigenome, brain, aging, neurogenesis, gene modification, human, cellular aging, neural stem cells, epigenetic changes, brain health, aging process, gene expression, neurological aging, brain function, genetic factors, aging brain, neurodegenerative diseases, DNA methylation, histone modification, aging-related genes epigenome, brain, human aging, neurogenesis, gene modification, epigenetic changes, neural development, age-related changes, genetic regulation, brain aging
921	Participating in six months of physical activity improves cognitive functioning. physical activity, cognitive functioning, six months, improvement, participation, exercise, brain health, longevity, mental acuity, fitness benefits physical activity, cognitive functioning, six months, improvement, participation, exercise, brain health, mental performance physical activity, cognitive functioning, six months, improvement, participation, health benefits, mental health, exercise duration, brain function, physical exercise, cognitive enhancement, long-term effects, fitness, neurological benefits physical activity, cognitive functioning, six months, improvement, participation physical activity, cognitive functioning, six months, participation, improvement, health benefits, mental health, exercise duration, cognitive enhancement, fitness impact
922	Patients in stable partnerships have a faster progression from HIV to AIDS. HIV, AIDS, progression, stable partnerships, patients, relationship status, health outcomes, viral progression, partnership impact, clinical studies, epidemiology, sexual health, demographic factors, comorbidity, treatment adherence HIV, AIDS, stable partnerships, faster progression, patients, relationship status, health outcomes, viral progression, partnership stability, medical research, epidemiology, sexual health, chronic illness management, partner support, immune response, healthcare access, socioeconomic factors, behavioral factors, treatment adherence, clinical studies, public health, infectious diseases, comorbidities, risk factors, longitudinal studies, health disparities, demographic analysis, global health, antiretroviral therapy, virus transmission, sexual behavior, health education, preventative care, mental health, social determinants, quality of life, patient outcomes, healthcare policies, health equity, community health, therapeutic HIV, AIDS, progression, stable partnerships, patients, sexual relationships, health outcomes, partner support, clinical studies, virology, epidemiology HIV, AIDS, progression, stable partnerships, patients, health outcomes, relationship status, virus transmission, immune response, medical research, epidemiology, sexual behavior, treatment adherence, partner support HIV, AIDS, patients, stable partnerships, progression, health relationships, immune response, viral load, sexual health, partner support
805	Monoclonal antibody targeting of N-cadherin inhibits metastasis. Monoclonal antibody, N-cadherin, inhibits, metastasis, cancer therapy, targeted treatment, cellular adhesion, tumor progression Monoclonal antibody, N-cadherin, inhibits, metastasis, cancer therapy, targeted therapy, adhesion molecules, tumor progression, metastatic disease, biomarker targeting Monoclonal antibody,N-cadherin,targeting,inhibits,metastasis,cancer therapy,antibody therapy,metastatic disease,N-cadherin inhibition monoclonal antibody, N-cadherin, inhibits, metastasis, cancer therapy, targeted therapy, protein targeting, metastatic inhibition, cancer research, molecular targeting Monoclonal antibody, N-cadherin, metastasis inhibition, cancer treatment, targeted therapy, biomarker, immune therapy, oncology research
808	Most termination events in Okazaki fragments are sequence specific. Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis, enzymatic activity, molecular biology, genetic processes Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis, molecular biology, genetic research, biochemical processes, nucleotide sequence, replication termination termination, Okazaki fragments, sequence specificity, DNA replication, lagging strand synthesis, primer removal Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis, RNA primer removal, DNA polymerase activity, molecular biology, genetics, biochemistry Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis
1121	Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites. Synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic signaling, synaptic plasticity, dendritic release, BDNF, neuronal function, synaptic transmission synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic signaling, synaptic plasticity, neuronal communication, dendritic function, neurotrophin dynamics, synaptic modulation synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophin secretion, synaptic plasticity, dendritic signaling synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic factors, synaptic function, dendritic release, neuronal communication, synaptic plasticity, BDNF secretion Synaptic activity, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophins, dendritic release, synaptic transmission, neuronal communication, brain function, neuroplasticity
1363	Venules have a thinner or absent smooth layer compared to arterioles. venules, thinner, absent, smooth, layer, arterioles, comparison, vascular, anatomy, histology Venules, thinner, absent, smooth, layer, arterioles, comparison, blood, vessels, anatomy, physiology venules, thinner, smooth, layer, absent, arterioles, comparison, anatomy, blood, vessels, physiology Venules, thinner, absent, smooth, layer, arterioles, comparison, structure, vascular, anatomy venules, thinner, absent, smooth, layer, arterioles, comparison, vascular, anatomy, blood, vessels, histology
1241	The myocardial lineage develops from cardiac progenitors of mesodermal origin. myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiovascular system, embryology, cell lineage, progenitor cells, mesoderm, myocardium myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, embryonic differentiation, mesoderm, cardiac mesoderm, myocardium, cardiac cells myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cell lineage, cardiovascular system, embryonic development, mesoderm, progenitor cells, myocardium myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cell lineage, progenitor cells, mesoderm, cardiac mesoderm, myocardium, cardiac development myocardial lineage, cardiac progenitors, mesodermal origin, heart development, embryonic cardiogenesis, cardiac mesoderm, myocardial differentiation, cardiac lineage specification
1362	Venules have a larger lumen diameter than arterioles. Venules, larger, lumen, diameter, arterioles Venules, lumen, diameter, arterioles, blood vessels, circulatory system, vascular anatomy, larger, comparison venules, lumen, diameter, arterioles, blood, vessels, cardiovascular, system, anatomy, physiology Venules, larger, lumen, diameter, arterioles, blood, vessels, circulatory, system, anatomy, physiology Venules, arterioles, lumen, diameter, blood vessels, circulatory system, vascular anatomy, physiology
491	HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years HNF4A, mutations, diabetes, mutant, carriers, age, 14, years, genetic, disorder, early, onset, insulin, resistance, pancreatic, beta, cells, transcription, factor, hepatocyte, nuclear, family, A, Maturity, Onset, Diabetes, Youth, MODY, clinical, implications, genetic, counseling, treatment, options, research, studies, medical, literature, reviews, case, reports, epidemiology, prevalence, symptoms, diagnosis, management, prognosis, lifestyle, interventions, pharmacological, therapies, pediatric, endocrinology, molecular, genetics, biochemistry, cellular, HNF4A, mutations, diabetes, mutant, carriers, age, 14, years, genetic, disorder, early-onset, insulin, glucose, metabolism, pancreas, beta-cells, molecular, basis, disease, pediatric, endocrinology, clinical, relevance HNF4A, mutations, diabetes, genetic disorder, juvenile diabetes, early onset diabetes, gene carriers, age 14, hereditary diabetes, molecular genetics HNF4A, mutations, diabetes, mutant, carriers, age, 14, years, genetic, disorder, juvenile, onset, insulin, resistance, pancreas, beta-cells, glucose, intolerance HNF4A, mutations, diabetes, mutant carriers, age 14 years, genetic disorder, early onset diabetes, pancreatic function, liver function, transcription factor, molecular genetics, endocrine system, glucose metabolism, pediatric diabetes, hereditary diabetes
130	Articles published in open access format are more likely to be cited than traditional journals. open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, accessibility, peer-reviewed articles, publication models, citation advantage open access, citation rates, traditional journals, academic publishing, research impact, scholarly communication, article influence, publication models, open science, citation advantage open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication formats, citing behavior, open science, peer-reviewed articles open access, citation rates, academic publishing, traditional journals, research visibility, impact factor, scholarly communication, open science, peer-reviewed articles, publication models open access, citation rates, academic publishing, traditional journals, research impact, scholarly communication, publication formats, access barriers, digital publishing, academic articles, citation analysis, open science
132	Aspirin inhibits the production of PGE2. Aspirin,PGE2,production,inhibits,nonsteroidal,anti-inflammatory,NSAID,cyclooxygenase,COX,prostaglandin,E2,inflammation,pain,fever Aspirin,PGE2,inhibits,production,anti-inflammatory,COX,prostaglandin,E2 Aspirin,PGE2,inhibition,production,anti-inflammatory,COX,prostaglandin synthase,cyclooxygenase Aspirin, PGE2, inhibition, production, cyclooxygenase, COX, anti-inflammatory, prostaglandin, E2, pharmacology, mechanism, action, drug, effect, biochemistry, medical, research, study, clinical, treatment, pain, fever, arthritis Aspirin,PGE2,inhibition,production,COX,prostaglandin synthase,anti-inflammatory,pain relief,fever reduction,cardiovascular benefits,platelet aggregation inhibition
133	Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. invadopodia, phosphatidylinositol-3,4-biphosphate, Src, nonreceptor tyrosine kinase, assembly, focal generation invadopodia assembly, phosphatidylinositol-3,4-biphosphate, Src activation, focal generation, nonreceptor tyrosine kinase, cell invasion, membrane protrusions, signaling pathways assembly, invadopodia, phosphatidylinositol-3,4-biphosphate, focal-generation, nonreceptor, tyrosine, kinase, Src, activation, cell-biology, molecular-signaling, cancer-research, cellular-dynamics invadopodia assembly, phosphatidylinositol-3,4-biphosphate, Src activation, focal generation, nonreceptor tyrosine kinase Assembly, invadopodia, phosphatidylinositol-3,4-biphosphate, focal-generation, activation, nonreceptor, tyrosine, kinase, Src
1359	Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, smoking cessation, clinical trials, pharmacotherapy varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, smoking cessation, comparative study, pharmacotherapy Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapies, bupropion, smoking cessation, clinical trials, pharmaceuticals, tobacco use disorder varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, smoking cessation, clinical outcomes Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination, nicotine replacement therapy, bupropion, smoking cessation, clinical trial, comparative study
137	Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. asymptomatic, visual, impairment, screening, elderly, populations, improved, vision, eye, health, older, adults, blindness, prevention, early, detection, treatment, outcomes, clinical, trials, research, studies, ophthalmology, optometry asymptomatic, visual, impairment, screening, elderly, populations, improved, vision, eye, health, aging, optical, disorders, detection, prevention, clinical, trials, studies, outcomes,elderly care, ophthalmology, public, health, interventions, effectiveness asymptomatic, visual, impairment, screening, elderly, populations, improved, vision, eye, health, senior,optic, assessment, prevention, care Asymptomatic, visual, impairment, screening, elderly, populations, vision, improvement, eye, health, seniors, blindness, preventative, care, ophthalmology, optometry, geriatrics, clinical, trials, efficacy, outcomes, public, health, interventions, treatment, effectiveness, research, studies, medical, reviews, meta-analysis Asymptomatic, Visual, Impairment, Screening, Elderly, Populations, Improved, Vision, Eye, Health, Elderly, Care, Preventive, Medicine, Ophthalmology, Optometry, Clinical, Trials, Health, Outcomes, Public, Health, Policy
1232	The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease. minor G allele, FOXO3, severe symptoms, Crohn's Disease, genetic association, inflammatory bowel disease, genetic marker, disease severity, allele frequency, SNP minor G allele, FOXO3, severe symptoms, Crohn's Disease, genetic association, inflammatory bowel disease, SNP, genotype-phenotype correlation minor G allele, FOXO3, severe symptoms, Crohn's Disease, genetic association, inflammation, bowel disease, SNP, allele frequency, disease severity, genotype-phenotype correlation FOXO3, G allele, Crohn's Disease, minor allele, disease severity, genetic association, inflammatory bowel disease, SNP, symptom severity, genetic predisposition FOXO3, minor G allele, Crohn's Disease, severe symptoms, genetic variation, inflammatory bowel disease, SNP, genotype-phenotype correlation
811	Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals. mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, knockout model, vitamin C transport, neural tissues, endocrine glands mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C, knockout mice, neuroendocrine tissues, oxidative stress, antioxidant defense, scurvy, ascorbate transport, neural function, adrenal gland function mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, genetic knockout, vitamin C, neurological studies, adrenal gland research mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C, knockout mice, neurotransmission, oxidative stress mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C, knockout mice, oxidative stress, neural function, adrenal gland, genetic modification, vitamin C metabolism, deficiency models
814	Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. G-Beta protein, GNB2, cancers, mutations, G-alpha subunits, interaction loss, AKT pathway, activation G-Beta protein, GNB2, mutations, cancers, G-alpha subunits, interaction loss, AKT pathway, activation G-Beta protein, GNB2, mutations, cancers, G-alpha subunits, AKT pathway, interaction loss, activation G-Beta, GNB2, mutations, cancers, G-alpha, subunits, interaction, loss, AKT, pathway, activation, concomitant G-Beta protein, GNB2, mutations, cancers, G-alpha subunits, AKT pathway, interaction loss, activation, oncogenesis, signaling pathways, G-protein coupled receptors, cancer biology, molecular interactions, cellular signaling
936	Peroxynitrite is required for nitration of TCR/CD8. Peroxynitrite, nitration, TCR, CD8, immune response, nitric oxide, reactive nitrogen species, lymphocyte activation, protein modification, signaling pathways peroxynitrite, nitration, TCR, CD8, immune response, nitric oxide, tyrosine nitration, lymphocyte activation, redox signaling, protein modification peroxynitrite, nitration, TCR, CD8, protein modification, immune response, signaling pathways, oxidative stress, inflammation, cellular immunity peroxynitrite, nitration, TCR, CD8, immune response, nitric oxide, reactive nitrogen species, protein modification, cellular signaling, lymphocyte activation Peroxynitrite, nitration, TCR, CD8, immune response, oxidative stress, nitric oxide, tyrosine nitration, lymphocyte activation, cellular signaling
36	A deficiency of vitamin B12 increases blood levels of homocysteine. vitamin B12, deficiency, homocysteine, blood levels, increase, health, nutrition, biochemistry vitamin B12, homocysteine, deficiency, blood levels, health, nutrition, metabolism, cardiovascular risk, anemia, neurological symptoms vitamin B12, deficiency, blood levels, homocysteine, increases, nutritional deficiency, methylation cycle, cardiovascular risk, neurological symptoms, anemia vitamin B12, homocysteine, deficiency, blood levels, increase, retrieval, query improvement vitamin B12, deficiency, homocysteine, blood levels, nutrition, health, metabolism, medical condition
1132	TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells. TCR, CD3, microdomains, immunologic synapse, T cell activation, lymphocyte, immune response, signal transduction, molecular biology, immunology, cell signaling, T-cell receptor, antigen recognition, immune system, cellular immunology TCR, CD3, microdomains, immunologic synapse, T cell activation, signaling complexes, immune response, lymphocytes, receptor signaling, molecular interactions TCR, CD3, microdomains, immunologic synapse, T cell activation, TCR-CD3 complex, immune response, cellular immunology, signaling pathways, lymphocyte activation TCR, CD3, microdomains, immunologic synapse, T cell activation, T lymphocytes, immune response, signaling pathways, cell surface receptors, leukocyte activation TCR, CD3, microdomains, immunologic synapse, T cell activation, signaling complex, immune response, lymphocyte activation, molecular clustering, cell membrane organization
1130	T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation. T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, immune suppression, cell-mediated immunity, inflammatory diseases, autoimmune disorders, immunology, T-cell regulation, integrin αvβ8, T-cell function, immune response modulation T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, immune suppression, cell-mediated immunity, inflammation regulation, T-cell mediated inflammation, immune response modulation T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, immune suppression, cellular immunity, regulatory T-cell function, inflammation regulation, αvβ8 integrin, immune response modulation T regulatory cells, tTregs, αvβ8, pathogenic T-cell responses, active inflammation, immune suppression, integrin, autoimmune diseases, immunology, cell signaling, inflammation regulation, T-cell activation, therapeutic targets T regulatory cells, tTregs, αvβ8, suppressing, pathogenic T-cell responses, active inflammation, immune regulation, cellular immunity, autoimmune diseases, inflammation modulation
380	Enhanced early production of inflammatory chemokines improves viral control in the lung. inflammatory chemokines, viral control, lung, enhanced production, early response, immune response, respiratory infection, cytokine expression, antiviral defense, innate immunity inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory viruses, cytokine storm, antiviral defense, acute respiratory infection inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory viruses, cytokine expression, antiviral defense, infection clearance inflammatory, chemokines, viral, control, lung, early, production, enhanced inflammatory chemokines, viral control, lung, early production, enhanced response, immune response, respiratory infections, cytokine storm, antiviral defense, pulmonary immunity
1370	Vitamin D deficiency is unrelated to birth weight. Vitamin D, deficiency, birth weight, unrelated, neonatal, pregnancy, maternal, health, nutrition, infant, outcomes, research, study, evidence, correlation, metrics, clinical, trials, public health, supplementation Vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, nutrition, maternal, infant Vitamin D, deficiency, birth weight, unrelated, neonatal, health, pregnancy, nutrition Vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, supplementation, maternal, infant, correlation, study, research, outcomes, nutrition vitamin D, deficiency, birth weight, unrelated, pregnancy, neonatal, health, supplementation, maternal, fetus
261	Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO mediation, cardiovascular health, exercise physiology, vascular biology, chronic exercise benefits, endothelium-dependent relaxation chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, improved circulation, exercise physiology, vascular biology, physical activity benefits chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, exercise physiology, vascular biology chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, exercise physiology, arterial function, blood flow regulation, endothelium-dependent relaxation chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO-mediated mechanisms, cardiovascular health, exercise physiology, vascular biology
141	Auditory entrainment is strengthened when people see congruent visual and auditory information. auditory entrainment, visual congruence, audio-visual integration, sensory synchronization, multimodal processing, perceptual alignment, enhanced neural responses, visual-auditory feedback, sensory enhancement, cross-modal interaction auditory entrainment, visual-auditory congruence, multisensory integration, sensory synchronization, crossmodal processing, perceptual alignment, neuroplasticity, brain synchronization, sensory enhancement, stimuli congruency auditory entrainment, visual information, congruent stimuli, multisensory integration, brain synchronization, sensory enhancement, perceptual processing, neural entrainment, crossmodal perception, audiovisual synchronization auditory entrainment, visual auditory congruence, sensory integration, crossmodal processing, perception synchronization, multimodal perception, sensory enhancement, brain plasticity, auditory visual interaction auditory entrainment, visual-auditory congruence, multisensory integration, perceptual synchronization, brain plasticity, sensory processing, cognitive neuroscience, audiovisual stimuli, neural entrainment, cross-modal perception
142	Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, comparative effectiveness, stem cell therapy, infection risk, immunosuppression, clinical outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher rate, immune response, stem cell therapy, transplantation complications, clinical outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immune response, clinical outcomes, transplantation risks autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immune response, transplantation complications, clinical outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, higher infection rate, stem cell therapy, immunosuppression, transplantation complications, clinical outcomes
384	Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings. Epidemiological, disease, burden, noncommunicable, diseases, prevalence, low, economic, settings, health, disparities, global, health, low-income, countries, chronic, conditions, morbidity, mortality, risk, factors, public, health, intervention, prevention, socioeconomic, status, healthcare, access, poverty, inequality epidemiology, disease burden, noncommunicable diseases, low economic settings, prevalence, public health, socioeconomic factors, health disparities, global health, chronic diseases Epidemiology, Disease Burden, Noncommunicable Diseases, Low Economic Settings, Prevalence, Health Disparities, Public Health, Global Health, Low-Income Countries, Chronic Diseases epidemiology, disease burden, noncommunicable diseases, low economic settings, prevalence, health economics, public health, socioeconomic factors, global health, chronic diseases Epidemiology, disease burden, noncommunicable diseases, low-income countries, economic factors, health disparities, global health, public health policy, chronic diseases, socioeconomic status
143	Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immune response, hematopoietic stem cells, clinical outcomes, transplant complications autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, clinical outcomes, comparative study, transplantation complications autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, comparative study, clinical outcomes, transplantation complications autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immune response, stem cell therapy, transplantation outcomes, infection prevention, immunosuppression methods Autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, stem cell transplantation, immunotherapy, cytokine receptor antagonists, medical treatment, hematopoietic stem cells, bone marrow transplantation, immune response, clinical trial, medical research, healthcare intervention, therapeutic efficacy, patient outcomes, immune modulation, stem cell therapy
385	Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immune modulation, cancer therapy, epigenetics, tumor microenvironment, immunotherapy, molecular targets Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immunomodulation, epigenetics, cancer therapy, immune response modulation, tumor microenvironment, cellular immunity, epigenetic regulation, cancer immunology Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immune modulation, cancer therapy, epigenetics, tumor microenvironment, immune cells, cancer treatment, pharmacology, molecular biology, oncology, immunotherapy epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immune modulation, cancer treatment, epigenetics, tumor microenvironment, immunotherapy, oncology Epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immunomodulation, epigenetics, cancer therapy, immune modulation, tumor microenvironment, molecular targets
386	Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations. errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations Errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations Errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations errors, peripheral, IV, drug, administration, bolus, multiple-step, medicine, preparations
1368	Vitamin D deficiency effects the term of delivery. Vitamin D deficiency, pregnancy, term delivery, gestational length, maternal health, neonatal outcomes Vitamin D, deficiency, pregnancy, delivery, term, gestation, health, outcomes, prenatal, care, nutrition, supplementation, maternal, fetus, development, complications, risk, factors, prevention, treatment Vitamin D, deficiency, pregnancy, delivery term, gestational period, prenatal health, nutrition, hormones, fetal development, maternal health Vitamin D deficiency, pregnancy outcomes, term delivery, preterm birth, gestational length, maternal health, fetal development, nutritional deficiencies, obstetrics, prenatal care Vitamin D, deficiency, pregnancy, term delivery, gestational outcomes, prenatal care, maternal health, infant health, nutritional status, bone health, immune function, hormone regulation
146	Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immune response, transplantation immunology, biological therapy, clinical outcomes autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, stem cell therapy, transplantation medicine, immune response, clinical outcomes autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immune response, stem cell therapy, transplantation immunology autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, transplant rejection, biocompatibility, medical treatment options Autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, cell transplantation, medical treatment, clinical outcomes
388	Ethanol stress decreases the expression of IBP in bacteria. ethanol, stress, decreases, expression, IBP, bacteria ethanol,stress,IBP,bacteria,expression,decreases ethanol,stress,decreases,expression,IBP,bacteria ethanol, stress, decreases, expression, IBP, bacteria ethanol,stress,expression,IBP,bacteria,downregulation,proteomics,microbiology,gene,regulation,response,molecular,mechanism
268	Cold exposure increases BAT recruitment. cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,heat production,cold acclimation,winter adaptation,metabolic rate,energy expenditure,body temperature regulation cold exposure, brown adipose tissue, BAT recruitment, thermogenesis, cold-induced thermogenesis, metabolic adaptation, adipocyte browning, cold acclimation, energy expenditure, fat burning, health benefits of cold, body temperature regulation cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,energy expenditure,winter adaptation,cold-induced thermogenesis,body temperature regulation cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold-induced thermogenesis, adipocytes, obesity, metabolic rate, energy expenditure, cold tolerance cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold acclimation, metabolic adaptations, energy expenditure, fat activation, physiological responses, cold-induced thermogenesis
1245	The one-child policy has been successful in lowering population growth. one-child policy, population growth, China, demographic changes, birth rate, family planning, government policy, population control, fertility rate, socioeconomic impact one-child policy, population growth, China, demographic impact, family planning, birth rate, population control, government policy, social impact, economic impact one-child policy, population growth, China, demographic control, fertility rates, population management, birth control policies, family planning, government intervention, social engineering, population studies, demographic trends, policy effectiveness, overpopulation solutions, reproductive health policies one-child policy, population growth, demographic control, family planning, China policy, birth rate reduction, population management, fertility rate decline, governmental population measures, reproductive health policies one-child policy, population growth, China, demographic control, birth rate, family planning, population management, government policy, reproductive policy, social engineering
148	Autophagy declines in aged organisms. autophagy, aged organisms, decline, aging, cellular processes, senescence, lysosomes, protein degradation, biological aging, longevity, healthspan autophagy, aged, organisms, decline, aging, biological processes, senescence, cellular degradation, lysosomes, longevity autophagy, declines, aged, organisms, aging, cellular-decline, organism-aging, autophagic-process, senescence, biological-aging autophagy, aged, organisms, decline, aging, cellular, degradation, lysosomes, longevity, healthspan autophagy, aging, aged organisms, decline, cellular processes, senescence, biological aging, organismal aging, cellular autophagy, age-related changes
269	Cold exposure reduces BAT recruitment. cold exposure,BAT recruitment,brown adipose tissue,thermal stress,metabolic adaptation,energy expenditure,thermogenesis,cold-induced thermogenesis,physiological response,cold acclimation cold exposure, BAT, recruitment, brown adipose tissue, thermogenesis, metabolism, cold-induced, adipocytes, energy expenditure, body temperature regulation cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,body temperature regulation,energy expenditure,fat metabolism,cold acclimation,hypothermia prevention,metabolic adaptation cold exposure,BAT recruitment,brown adipose tissue,thermal stress,energy expenditure,body temperature regulation Cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,energy expenditure,cold-induced thermogenesis,adipocyte recruitment,metabolic adaptation,cold acclimation,fat metabolism
820	N-terminal cleavage increases success identifying transcription start sites. N-terminal, cleavage, transcription, start, sites, identification, success, protein, sequencing, bioinformatics, genomics, molecular, biology, proteomics N-terminal,cleavage,transcription,start,sites,identification,success,proteomics,bioinformatics,gene,expression,analysis N-terminal, cleavage, transcription, start, sites, identification, success, protein, sequencing, bioinformatics, genomics N-terminal,cleavage,transcription,start,sites,identification,success,bioinformatics,gene,expression,analysis,molecular,biology N-terminal, cleavage, transcription, start, sites, identification, success, protein, sequencing, bioinformatics, genomics
700	Localization of PIN1 in the Arabidopsis embryo does not require VPS9a Localization,PIN1,Arabidopsis,embryo,VPS9a PIN1, Arabidopsis, embryo, VPS9a, localization, plant development, auxin transport, vesicle trafficking Localization, PIN1, Arabidopsis, embryo, VPS9a, protein, plant, development, trafficking, endocytosis PIN1, Arabidopsis, embryo, VPS9a, localization, plant development, vesicle trafficking, auxin transport, protein distribution, seed development PIN1, Arabidopsis, embryo, localization, VPS9a, plant development, endocytosis, vesicle trafficking, auxin transport, gene expression, molecular biology, plant genetics
821	N-terminal cleavage reduces success identifying transcription start sites. N-terminal,cleavage,transcription,start,sites,protein,sequencing,bioinformatics,gene,expression,analysis,molecular,biology N-terminal,cleavage,transcription,start,sites,identification,reduction,success,failure,protein,sequence,bioinformatics,gene,expression-analysis N-terminal, cleavage, success, identifying, transcription, start, sites, bioinformatics, gene, expression, analysis, sequencing, molecular, biology, protein, modification N-terminal, cleavage, transcription, start, sites, identification, success, protein, sequencing, bioinformatics, genomics, molecular, biology, enzymatic, processing, peptide, analysis, regulatory, regions, gene, expression, initiation, factor, binding, site, detection, methods, challenges, improvement, techniques, accuracy, efficiency N-terminal, cleavage, transcription, start, sites, success, identification, reduction, bioinformatics, molecular, biology, genomics, proteomics, sequencing, analysis, enzyme, activity, impact, research, science, technology, methods, techniques, improvement, efficiency, accuracy
702	Localization of PIN1 in the roots of Arabidopsis does not require VPS9a Localization, PIN1, roots, Arabidopsis, VPS9a, protein trafficking, plant biology, cellular localization, endocytosis, vesicular transport Arabidopsis, roots, PIN1, VPS9a, localization, plant biology, molecular genetics, cellular transport, vesicle trafficking, developmental biology PIN1, Arabidopsis, roots, VPS9a, localization, plant biology, molecular biology, cellular transport, vesicle trafficking, auxin transport Localization, PIN1, Roots, Arabidopsis, VPS9a, Plant Biology, Cell Biology, Protein Trafficking, Root Development, Vacuolar Protein Sorting PIN1, Arabidopsis, roots, localization, VPS9a, plant biology, molecular genetics, protein trafficking, endocytosis, vesicle trafficking, developmental biology, plant roots, membrane proteins, cellular localization, vesicle-mediated transport, plant cellular biology, auxin transport, plant development, gene expression, plant signaling pathways
823	N348I mutations cause resistance to zidovudine (AZT). N348I,muations,resistance,zidovudine,AZT,HIV,treatment,failure,drug,antiretroviral,therapy,viral,mutations,AIDS,reverse,transcriptase,inhibitors N348I, mutations, resistance, zidovudine, AZT, HIV, antiretroviral, treatment, genetic, variation, drug, therapy N348I, mutations, resistance, zidovudine, AZT, HIV, treatment, antiretroviral, drug, therapy, virology, molecular, biology, genetics, clinical, research, pharmaceutical, medicine N348I,mutations,resistance,zidovudine,AZT,HIV,therapy,retroviral,drug,resistance,mutation,sites,AZT-resistant,strains,treatment,failure,antiretroviral,pharmacology,viral,enzymes,reverse,transcriptase,inhibition,molecular,mechanisms,clinical,implications N348I, mutations, resistance, zidovudine, AZT, HIV, antiretroviral, drug, therapy, treatment, viral, strain, resistance, mechanism, clinical, study, research, molecular, genetics, pharmacology
42	A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. high microerythrocyte count, severe anemia, homozygous alpha thalassemia, thalassemia trait, hemoglobinopathy, genetic disorder, red blood cells, erythropoiesis, hematological condition, medical genetics microerythrocyte count, severe anemia, homozygous alpha thalassemia, thalassemia trait, hematological disorders, genetic blood disorders, red blood cell morphology, alpha globin genes, clinical hematology, anemia symptoms, genetic predisposition, blood cell count, thalassemia complications, hemoglobinopathies, health risk factors high microerythrocyte count, severe anemia, homozygous alpha-thalassemia, hemoglobinopathy, genetic disorder, red blood cells, hematological condition, health risk, medical diagnosis, blood disorder, alpha-thalassemia trait, erythrocyte abnormality, anemia susceptibility, genetic hemoglobinopathy, clinical pathology high microerythrocyte count, severe anemia, homozygous alpha-thalassemia, alpha plus thalassemia trait, erythrocyte parameters, hemoglobin disorders, genetic anemias, hematological findings, clinical implications, thalassemia syndrome, blood cell morphology high microerythrocyte count, severe anemia, homozygous alpha thalassemia, alpha plus thalassemia, hematological disorders, blood disorders, genetic anemia, red blood cell morphology, thalassemia trait, clinical hematology
48	A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. UK, asymptomatic, carriers, vCJD, infection, 1000, people UK, asymptomatic, carriers, vCJD, infection, people, total, 1000 UK, asymptomatic, carriers, vCJD, infection, 1000, people vCJD, asymptomatic carriers, UK, infection, people, total, 1000 vCJD, asymptomatic, carriers, infection, UK, 1000, people
49	ADAR1 binds to Dicer to cleave pre-miRNA. ADAR1, Dicer, pre-miRNA, cleavage, binding, miRNA processing ADAR1, Dicer, pre-miRNA, binding, cleavage, miRNA processing ADAR1, Dicer, pre-miRNA, cleavage, binding, RNA processing, miRNA biogenesis, enzymatic interaction, molecular biology, gene regulation ADAR1, Dicer, pre-miRNA, cleavage, binding, microRNA processing, RNA editing, RNA interference ADAR1, Dicer, pre-miRNA, cleavage, RNA binding, microRNA processing
1385	cSMAC formation enhances weak ligand signalling. cSMAC, formation, enhances, weak, ligand, signalling, immunological, synapse, T-cell, receptor, activation, cellular, response, biochemical, pathway, microcluster, recruitment, antigen, presentation cSMAC, formation, enhances, weak, ligand, signalling, immunological, synapse, T-cell, activation, antigen, receptor, signaling, pathway, molecular, interaction, cell, biology, immunology cSMAC, formation, enhances, weak, ligand, signalling, cell-signaling, T-cell, immune-response, molecular-interactions, signaling-pathways, immunology, biosignaling, biophysics, cell-biology, protein-interactions, biochemistry cSMAC, formation, enhances, weak, ligand, signalling, immunological, synapse, T-cell, activation, molecular, interaction, protein, receptor, biology, signaling, pathway, enhancement, cellular, response, immune, system, kinetics, affinity cSMAC, formation, enhances, weak, ligand, signalling, cellular, adhesion, T-cell, activation, immune, response, molecular, mechanisms, biochemistry, cell, biology, immunology, signaling, pathways
1021	Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus. Rapid up-regulation, higher basal expression, interferon-induced genes, survival reduction, granule cell neurons, West Nile virus infection Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neuronal damage, viral infection response, gene expression changes, neurotropic viruses Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neuronal infection, viral response, gene expression changes, neuroinflammation, cytokine response, innate immunity, brain infection, neurotropic virus, cellular defense mechanisms rapid up-regulation, higher basal expression, interferon-induced genes, survival reduction, granule cell neurons, West Nile virus infection, neural response, viral pathogenesis, gene expression modulation, neurotropic virus, cellular defense mechanisms Rapid up-regulation, higher basal expression, interferon-induced genes, reduced survival, granule cell neurons, West Nile virus infection, neurological impact, viral pathogenesis, gene expression changes, neurotropic viruses, cellular defense mechanisms, interferon response
1020	Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus. Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus infection, neuronal protection, antiviral response, gene expression, neurotropic viruses Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, infected, West Nile virus Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus infection, neuroprotection, viral infection, gene expression, neuronal survival, interferon response, neurotropic viruses Rapid up-regulation, interferon-induced genes, higher basal expression, survival, granule cell neurons, West Nile virus infection, neuronal protection, viral response, gene expression, neurovirology, immunology, virology, neuroscience Rapid up-regulation, higher basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus infection, neuroprotection, viral response, gene expression, neuronal survival, antiviral defense, interferon response, granule cell protection, WNV infection, innate immunity, brain infection, neurotropic virus, gene up-regulation, basal gene expression, neuron viability, viral-induced gene changes, interferon pathway activation, neurodegeneration prevention, viral encephalitis, interferon-stimulated genes, neuronal infection defense, brain immune response, granule cell preservation, virus-induced gene modulation, neuro
1262	The repair of Cas9-induced double strand breaks in human DNA is error-prone. Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR-Cas9, DNA repair mechanisms, molecular biology, genetic engineering, NHEJ, homologous recombination, off-target effects, biotechnology research, somatic cells, germline cells, genetic disorders, mutation repair, biomedicine, clinical implications, therapeutic applications, scientific breakthrough, ethical considerations, genome instability, cellular response, DNA damage response, repair fidelity, chromosomal aberrations, targeted gene therapy, precision medicine, molecular genetics, DNA damage, cellular repair pathways, genetic modification, CRISPR technology, bio Cas9, double strand breaks, human DNA, repair, error-prone, genome editing, CRISPR, molecular biology, genetic modification, NHEJ, HDR, mutagenesis, cell repair mechanisms, DNA damage response Cas9, double strand breaks, human DNA, repair mechanisms, error-prone, genome editing, CRISPR, molecular biology, genetic repair, DNA damage response Cas9, double strand breaks, DNA repair, human DNA, error-prone repair, CRISPR, genome editing, molecular biology, genetic engineering, NHEJ, homologous recombination Cas9, double strand breaks, human DNA, error-prone repair, genome editing, CRISPR, cellular repair mechanisms, mutation, genetic repair, molecular biology
1140	Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer. α-tocopheryl acetate, prostate cancer, prevention, 400mg, vitamin E, supplementation, health benefits, oncology, antioxidants α-tocopheryl acetate, prostate cancer, prevention, dosage, 400mg, vitamin E, antioxidants, health benefits, male health, dietary supplements α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, antioxidant, health supplementation, cancer risk reduction α-tocopheryl acetate, prostate cancer, prevention, 400mg, vitamin E, α-tocopherol, antioxidants, cancer prevention, dietary supplements, men's health α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, health benefits, antioxidants, clinical studies, risk reduction, male health
1382	aPKCz causes tumour enhancement by affecting glutamine metabolism. aPKCz, tumour enhancement, glutamine metabolism, cancer, protein kinase C zeta, metabolic pathways, oncogenesis, tumorigenesis, cellular metabolism, glutamine utilization, signaling pathways, cancer metabolism, tumor growth, enzyme activity, metabolic reprogramming aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolic pathways, cell signaling, oncogenesis, treatment targets aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolic pathways, oncology, cell proliferation, tumorigenesis, nutrient sensing, amino acid metabolism aPKCz, tumour enhancement, glutamine metabolism, cancer, kinase activity, metabolic pathways, glioma, tumorigenesis, oncology, cellular metabolism aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolic pathways, cell signaling, oncogenesis, tumorigenesis, protein kinases, glutamine-dependent growth
274	Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy. nicotine replacement therapies, varenicline, bupropion, combination therapy, long-term abstinence, 52 weeks, smoking cessation, monotherapy, clinical trials, tobacco dependence treatment Combination therapy, nicotine replacement, varenicline, bupropion, long-term abstinence, 52 weeks, smoking cessation, monotherapy, comparative effectiveness Combination therapy, nicotine replacement, varenicline, bupropion, long-term abstinence, 52 weeks, smoking cessation, monotherapy, treatment efficacy, clinical outcomes Combination, nicotine, replacement, therapies, varenicline, bupropion, long-term, abstinence, rates, 52, weeks, monotherapy nicotine replacement therapy, varenicline, bupropion, combination therapy, smoking cessation, long-term abstinence, 52 weeks, monotherapy, clinical trials, tobacco use disorder
1019	Rapid phosphotransfer rates govern fidelity in two component systems Rapid phosphotransfer, rates, fidelity, two component systems, bacterial signaling, protein phosphorylation, regulatory mechanisms, microbial genetics, signal transduction, molecular biology Rapid phosphotransfer, fidelity, two component systems, bacterial signaling, protein phosphorylation, regulatory networks, microbial biochemistry, enzymatic kinetics, signal transduction, molecular biology Rapid phosphotransfer, two component systems, fidelity, bacterial signaling, kinase activity, phosphorelay mechanisms, microbial regulation, signal transduction, protein phosphorylation, enzyme kinetics Rapid phosphotransfer, fidelity, two component systems, bacterial regulation, signal transduction, enzymatic kinetics, biochemistry, molecular biology, protein interaction, cellular signaling Rapid phosphotransfer, rates, fidelity, two component systems, bacterial signaling, protein kinases, response regulators, microbial communication, signal transduction, enzymatic activity
275	Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, metastatic cancer, precision medicine, oncology, molecular targeting phosphatidylinositide 3-kinase, MEK inhibitors, KRAS mutant, tumors, combination therapy, cancer treatment, signaling pathways, targeted therapy phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, oncology, tumor inhibition, pharmacological synergy, clinical trials, molecular targeted therapy, cancer research, signaling pathways, drug interaction, mutation-specific treatment KRAS mutant tumors, phosphatidylinositide 3-kinase inhibitors, MEK 1/2 inhibitors, combination therapy, cancer treatment, targeted therapy, signaling pathways, tumor suppression, clinical trials, oncology, drug synergy, mutant KRAS, cancer research, molecular targets, therapeutic strategies phosphatidylinositide 3-kinase, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, targeted therapy, molecular targeted agents, signaling pathway inhibition, oncology, clinical trial, drug efficacy, tumor suppression, mutation-specific treatment
1259	The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up. breast cancer, tamoxifen metabolism, treatment outcomes, genetic predisposition, patient genetics, pharmacogenomics, drug efficacy, oncology treatment, genetic variability, metabolism genetics breast cancer, tamoxifen metabolism, treatment outcome, genetic makeup, patient genetics, pharmacogenetics, cancer treatment, metabolic capacity, genetic variation, drug efficacy breast cancer, tamoxifen metabolism, treatment outcome, genetic make-up, patient genetics, pharmacogenetics, tamoxifen efficacy, genetic variation, cancer treatment response, metabolic capacity breast cancer, tamoxifen metabolism, treatment outcome, genetic variation, pharmacogenomics, patient genetics, drug efficacy, personalized medicine, CYP2D6 genotype, clinical response breast cancer, tamoxifen metabolism, treatment outcome, genetic makeup, patient genetics, pharmacogenomics, tamoxifen efficacy, cancer treatment response, genetic polymorphisms, drug metabolism genetics
1137	TNFAIP3 is a tumor suppressor in glioblastoma. TNFAIP3, tumor suppressor, glioblastoma, cancer, gene expression, neuro-oncology, molecular biology, A20, apoptosis, cell signaling, inflammation, genetic mutations, therapy target, prognosis, immune response, intracellular signaling cascades TNFAIP3,glioblastoma,tumor,suppressor,gene,expression,cancer,bioinformatics,therapy,target,molecular,mechanism,biomarker,oncology,genomics,proteomics TNFAIP3, tumor suppressor, glioblastoma, cancer, A20, inflammation, neuro-oncology, molecular biology, genetic studies, oncogenes, apoptosis, cell growth, signaling pathways, therapy targets, clinical research, biomarkers, tumorigenesis, brain tumors, medical genetics, expression analysis TNFAIP3, tumor suppressor, glioblastoma, cancer gene, A20, neuro-oncology, brain tumor, molecular biology, genetic research, oncology TNFAIP3, tumor suppressor, glioblastoma, cancer, A20, NF-kB pathway, neuro-oncology, genetic research, molecular biology, medical science, brain tumor, oncology, apoptosis, cell death, inflammation, immune response
1379	Women with a higher birth weight are more likely to develop breast cancer later in life. Women, higher birth weight, breast cancer, later life, health risk, medical study, cancer research, obesity, hormonal factors, prenatal development, adult health, epidemiology women, higher birth weight, breast cancer, risk, later life, health outcomes, epidemiology, medical research, oncology, reproductive health women, higher birth weight, breast cancer, later life, risk factors, health outcomes, epidemiology, medical research, public health, cancer prevention women, higher birth weight, breast cancer, later life, health risk, medical research, epidemiology, hormonal factors, genetic predisposition, lifestyle factors women, higher birth weight, breast cancer, later life, risk factors, health outcomes, epidemiology, medical research, oncology, female health
399	Exposure to fine particulate air pollution is relate to anxiety prevalence. exposure, fine, particulate, air, pollution, related, anxiety, prevalence, mental, health, environmental, factors, studies, research, public, health, risks, impact, correlation exposure, fine, particulate, air, pollution, anxiety, prevalence, mental, health, environmental, factors, public, health, epidemiology, studies, correlations, respiratory, disorders, urban, areas, climate, change, pollution, sources, reduction, strategies, policy, implications Exposure, fine, particulate, air, pollution, anxiety, prevalence, health, environmental, impact, mental, illness, correlation, study, research, public, policy, urban, rural, global, health, effects, respiratory, cardiovascular, neurological, disorders, prevention, control, measures, air, quality, improvement, strategies, epidemiology, statistics, data, analysis, risk, factors, demographic, socioeconomic, status, lifestyle, habits, genetic, predisposition, comorbidities, treatment, interventions, counseling, therapy, medication, awareness, education, campaigns, advocacy, regulation, legislation, monitoring, assessment, reporting air pollution, fine particulate matter, PM2.5, anxiety, mental health, exposure, prevalence, environmental factors, public health, respiratory diseases, cardiovascular diseases, urban areas, air quality Exposure, fine, particulate, air, pollution, relate, anxiety, prevalence, environmental, health, respiratory, mental, urban, rural, concentration, levels, risk, factors, public, policy, mitigation, strategies, research, studies, correlation, impact, effects
279	Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs. Commelina yellow mottle virus, ComYMV, genome, size, base pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489 Commelina, yellow, mottle, virus, ComYMV, genome, base, pairs, 7489
1014	Rapamycin decreases the concentration of triacylglycerols in fruit flies. rapamycin, triacylglycerols, fruit flies, concentration reduction, lipid metabolism, drosophila melanogaster, biochemistry, pharmacology, genetics, aging research Rapamycin, triacylglycerols, fruit flies, lipid metabolism, mTOR pathway, dietary restriction, aging research, biochemical signaling, insect physiology, fat storage regulation rapamycin, triacylglycerols, fruit flies, concentration reduction, metabolism, lipid levels, Drosophila melanogaster, pharmacological effect, dietary intervention, lifespan extension, healthspan improvement, gene expression modulation, cellular senescence delay, age-related diseases prevention rapamycin, triacylglycerols, fruit flies, concentration reduction, metabolic effect rapamycin, triacylglycerols, fruit flies, concentration reduction, lipid metabolism, Drosophila melanogaster, pharmacological effect, biochemical analysis, health span, longevity research
830	NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases. NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway, cell growth, tumor suppression NF2, Merlin, phosphorylation, YAP, Drosophila, LATS1, LATS2, kinases, cytoplasmic sequestration, Hippo pathway NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, LATS1, LATS2, kinases, hippo pathway NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway
831	NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila. NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell growth, organ size control NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell growth, organ size regulation NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell growth, organ size regulation
1012	Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume. Radioiodine,treatment,non-toxic,multinodular,goitre,reduces,thyroid,volume Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume Radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume radioiodine, treatment, non-toxic, multinodular, goitre, reduces, thyroid, volume
832	NFAT4 activation requires IP3R-mediated Ca2+ mobilization. NFAT4, IP3R, Ca2+ mobilization, activation, signaling pathway, calcium signaling, ion channel, transcription factor, cellular response, calcium release NFAT4, IP3R, Ca2+ mobilization, activation, signaling, calcium signaling, ion channels, second messengers, cellular processes, gene regulation NFAT4, activation, IP3R, Ca2+ mobilization, calcium signaling, IP3 receptor, nuclear factor of activated T cells 4, intracellular calcium release, calcium ion regulation, signal transduction pathway NFAT4, activation, IP3R, Ca2+, mobilization, signaling, pathway, calcium, ion, receptor, intracellular, molecular, biology, cell, physiology NFAT4, activation, IP3R, Ca2+ mobilization, calcium signaling, intracellular calcium, ion channels, transcription factors, calcium release, endoplasmic reticulum
834	NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates. NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reaction, enzymatic, non-enzymatic, oxidative, stress, inflammation, signaling, biology, chemistry, biochemistry, medical, research, science, physiology, pathology NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reactive, nitric, oxide, superoxide, anion, NADPH, oxidase, alternative, sources, ROS, RNS, cellular, signaling, inflammation, oxidative, stress NOX2-independent, pathways, generate, peroxynitrite, nitrogen, intermediates, reactive, species, oxidative, stress, nitric, oxide, superoxide, dismutase, inflammation, cellular, signaling NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reactive, species, oxidative, stress, signaling, inflammation, enzymatic, reactions, biochemistry, molecular, biology, nitric, oxide, superoxide, radicals, cellular, processes NOX2-independent, pathways, peroxynitrite, nitrogen, intermediates, generation, reactive, nitric, oxide, superoxide, cellular, signaling, inflammation, oxidative, stress
956	Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling. GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, receptor signaling, effector coupling, cellular responses, signal transduction, pharmacology GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, receptors, signaling pathways, cell biology, pharmacology, endocrinology GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles, receptor signaling, effector coupling, cellular response diversity GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles GLP-1R, intracellular effectors, cellular signaling, pleiotropic coupling, distinct profiles
50	AIRE is expressed in some skin tumors. AIRE, skin, tumors, expression, dermatology, oncology, biomarker, pathology AIRE, skin, tumors, expression, dermatology, oncology, immunology, pathology, biomarker, cancer AIRE, skin, tumors, expression, dermatology, oncology, immunology AIRE, skin, tumors, expression, dermatology, oncology, immunology,oodoo AIRE, skin, tumors, expression, dermatology, oncology, immune, biology, medical, research, pathology
715	Low expression of miR7a does represses target genes and exerts a biological function in ovaries. miR7a, low expression, represses, target genes, biological function, ovaries miR7a, low expression, represses, target genes, biological function, ovaries, microRNA, gene regulation, ovarian biology, miRNA function miR7a, low expression, target genes, repression, biological function, ovaries miR7a, low expression, represses, target genes, biological function, ovaries, gene regulation, microRNA, ovarian biology miR7a, low expression, represses, target genes, biological function, ovaries
957	Podocytes are motile and migrate in the presence of injury. podocytes,motility,migration,injury,kidney,glomerulus,cell-movement,response-to-damage,nephrology 若要进一步优化检索，可以添加以下关键词：podocyte-dynamics,glomerular-injury,renal-cell-migration,cellular-mobility,adaptive-response Podocytes, motility, migration, kidney injury, glomerular damage, cellular movement, renal pathology podocytes,motility,migration,injury,kidney,glomerulus,cell-movement,renal-disease,tissue-repair Podocytes,motility,migration,injury,kidney,epithelial,cells,glomerulus,renal,damage,reparation,movement,cellular,trauma,repair Podocytes,motile,migrate,injury,kidney,epithelial,cells,reparative,movement,glomerulus
51	ALDH1 expression is associated with better breast cancer outcomes. ALDH1, breast cancer, outcomes, expression, prognosis, biomarker, oncology, survival, tumor, therapy, molecular markers, cancer research, clinical studies, gene expression, improved outcomes, patient survival, cancer biology ALDH1, breast cancer, gene expression, prognosis, survival, biomarker, oncology, tumor biology, clinical outcomes, cancer research ALDH1, breast cancer, outcomes, expression, prognosis, biomarker, survival, tumor, oncology, clinical research ALDH1, expression, breast, cancer, outcomes, prognosis, biomarker, survival, association, therapeutic, target ALDH1, expression, breast, cancer, outcomes, prognosis, biomarker, survival, oncology, tumor, markers, clinical, research, treatment, response, molecular, biology, medical, science
716	Low expression of miR7a exerts a biological function in testis. miR7a, low expression, biological function, testis, microRNA, gene regulation, male fertility, reproductive system, RNA expression, tissue-specific expression miR7a, testis, low expression, biological function, male reproduction, sperm development, gene regulation, microRNA, infertility, spermatogenesis miR7a, low expression, biological function, testis, gene regulation, RNA, microRNA, male fertility, spermatogenesis miR7a, low expression, testis, biological function, gene regulation, reproductive system, microRNA, male fertility, sperm development miR7a, low expression, biological function, testis, microRNA, gene regulation, male reproduction, spermatogenesis
837	NR5A2 is important in development of endometrial tissues. NR5A2, endometrial development, tissue development, NR5A2 function, endometrium, gene expression, reproductive biology, developmental biology, hormonal regulation, cell differentiation NR5A2, endometrial development, tissue development, NR5A2 function, endometrium, reproductive biology, gene expression, developmental biology, molecular biology, hormonal regulation NR5A2, endometrial development, tissue development, NR5A2 function, endometrial tissues, developmental biology, gene expression, hormonal regulation, endometrium, orchestrating development, cell differentiation, molecular biology, reproductive tissues, transcription factor NR5A2 NR5A2, endometrial development, tissue development, NR5A2 function, endometrium, gene expression, reproductive biology, molecular biology, developmental biology NR5A2, endometrial development, endometrial tissues, NR5A2 function, tissue development, endometrial biology
53	ALDH1 expression is associated with poorer prognosis in breast cancer. ALDH1, breast cancer, prognosis, expression, poorer outcome, biomarker, tumor, oncology, molecular marker, clinical significance ALDH1, breast cancer, prognosis, expression, poorer outcome, biomarker, oncology, tumor marker, cancer research, clinical correlation ALDH1, expression, breast cancer, prognosis, biomarker, oncology, tumor, survival, clinical outcome, cancer research ALDH1, expression, poorer, prognosis, breast, cancer, biomarker, correlation, survival, oncology, tumor, marker, clinical, outcome, research, medical, pathology, oncological, therapy, treatment, diagnostics, molecular, genetics, gene, protein, oncogenic, progression, metastasis, resistance, therapy, response, patient, care, health, science, cellular, biology, tissue, immunohistochemistry, staining, expression, levels, studies, analysis, statistical, data, clinical, trials, medical, literature, review, article, publication, scientific, journal, study, investigation, experiment, methodology, ALDH1, expression, breast cancer, prognosis, poorer, association, biomarker, oncology, tumor, malignancy
718	Low nucleosome occupancy correlates with low methylation levels across species. nucleosome occupancy, methylation levels, species comparison, epigenetic regulation, DNA methylation, chromatin structure, cross-species analysis low nucleosome occupancy, low methylation levels, species comparison, epigenetic regulation, chromatin structure, DNA methylation, nucleosome positioning, genetic correlation, cross-species analysis, molecular biology, genomics, bioinformatics Low nucleosome occupancy, low methylation levels, species comparison, epigenetic regulation, chromatin structure, DNA accessibility, genomic regions, gene expression, evolutionary conservation, methylome analysis, nucleosome positioning, bioinformatics tools, chromatin Immunoprecipitation, sequencing techniques, transcription factor binding, regulatory elements, enhancers, promoters, genome-wide studies, cellular differentiation, histone modifications, chromatin states, functional genomics, molecular biology, epigenetics, cross-species analysis, methylation patterns, nucleosome dynamics low nucleosome occupancy, low methylation levels, species comparison, epigenetic regulation, genomic regions, DNA methylation, chromatin structure, transcription factor binding, evolutionary conservation, gene expression regulation low nucleosome occupancy, low methylation levels, species correlation, epigenetics, DNA methylation, chromatin structure, genomic regulation, cross-species analysis, transcriptional activity, gene expression regulation
839	Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles. Nanoparticles, targeted delivery, cell types, aptamers, lipid nanoparticles, biotechnology, drug delivery systems, molecular targeting, therapeutic applications, nanomedicine Nanoparticles, targeted delivery, specific cell types, aptamers, lipid nanoparticles, drug targeting, nanotechnology, cellular targeting, molecular recognition, therapeutic nanoparticles nanoparticles, aptamers, lipid nanoparticles, cell targeting, specific cell types, drug delivery, biomedical applications, nanotechnology, targeted therapy Nanoparticles, targeted delivery, cell types, aptamers, lipid nanoparticles, drug delivery systems, biotechnology, nanotechnology, medical research, therapeutic applications Nanoparticles, aptamers, lipid nanoparticles, targeted delivery, cell-specific targeting, drug delivery systems, therapeutic nanoparticles, biomolecular engineering, nanomedicine, RNA delivery
54	AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory system, pulmonary disorders, signaling pathways, cellular response AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory, pulmonary, signaling pathway, disease mechanism AMPK, activation, inflammation, fibrosis, lungs AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory diseases, pulmonary fibrosis, signaling pathways, immune response AMPK, activation, inflammation, fibrosis, lungs, protein kinase, respiratory system, pulmonary disease, signaling pathway, cellular response, tissue damage, chronic inflammation, lung pathology, molecular mechanism
56	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, cellular models, neurological disorders APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, neuronal dysfunction, protein aggregation APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, cellular models, neuronal dysfunction APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, genetic risk factors, neuronal dysfunction, protein expression, cell culture, neurobiology, molecular biology, neuroscience APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, genetic factors, cellular models, neuronal dysfunction
57	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, protein expression, cellular models, neurological disorders APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, neuronal cells, protein phosphorylation, neuroprotective mechanisms APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, neural stem cells, protein expression, cellular models, neurobiology, molecular biology, neuroscience, genetic factors, brain disorders APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, gene expression, cellular models, Alzheimer's disease, neuroprotective mechanisms APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, gene expression, cellular models, neuron protection
1274	The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins. T6SS, Escherichia coli, E. coli, toxic effector proteins, inner tube, antibacterial effector, type VI secretion system, tip structure, bacterial toxins, protein delivery mechanism T6SS, Escherichia coli, inner tube, toxic effector proteins, antibacterial, secretion system, E. coli, T6SS effector, microbial, proteomics, bacteriology, pathogenicity, infection, molecular biology, structural biology, protein secretion, bacterial toxins, effector delivery, microbe-microbe interactions, virulence factors T6SS, Escherichia coli, E. coli, toxic effector proteins, inner tube, antibacterial effector, type VI secretion system T6SS, antibacterial, effector, Escherichia coli, E. coli, toxic, inner tube, tip, proteins T6SS, inner tube, toxic effector, E. coli, antibacterial, protein secretion, effector proteins, tip structure, bacterial defense, microbial interactions
1395	p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). p16INK4A, accumulation, abnormal, wound, response, microinvasive, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, step, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasion, advanced, Oral, Potentially, Malignant, Lesions, OPMLs p16INK4A, accumulation, abnormal, wound, response, microinvasive, advanced, Oral, Potentially, Malignant, Lesions, OPMLs
1273	The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly. kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, mitosis, cell division, molecular motors, microtubules, spindle dynamics kinesin-8, Kip3, sliding activity, bipolar spindle, spindle assembly, protein function, mitosis, cell division, microtubule dynamics, molecular motors kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, microtubule dynamics, mitosis, cell division, motor proteins, spindle formation kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, mitosis, cell division, microtubule dynamics, molecular motors, spindle formation kinesin-8, Kip3, sliding activity, bipolar spindle assembly, protein function, microtubule dynamics, cell division, mitosis, meiosis, molecular motors
1272	The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells. ON-bipolar cells, flash-evoked ERG, b-wave, retina, photoreceptors, neural response, electrophysiology, visual system, cellular activity, light stimulation ERG, b-wave, ON-bipolar cells, flash-evoked, retina, electrophysiology, visual system flash-evoked, ERG, b-wave, ON-bipolar, cells, activity, single, generation, electrophysiology, retina, visual, system, neuroscience flash-evoked ERG, b-wave, ON-bipolar cells, retinal activity, electroretinogram, visual system, neuronal response, photoreceptor signaling ERG, b-wave, ON-bipolar cells, flash-evoked, electroretinogram, retinal function, visual system, photoreceptors, bipolar cell activity, retinal response, light stimulus
1150	Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia Tetraspanin-3, acute myelogenous leukemia, causative factor, leukemia development, myeloid cancer, Tetraspanin proteins, AML, hematopoietic malignancy, oncogenesis, leukemogenesis Tetraspanin-3, acute myelogenous leukemia, causative factor, development, leukemia, myelogenous, Tetraspanin, cancer, hematopoietic, oncogene, tumor, progression, bone marrow, blood cells, malignant, genetic mutation, therapy, biomarker, prognosis, treatment, clinical trials, research, medical, health, biology, molecular, cellular, signal transduction, pathway, drug target, inhibition, expression, regulation, molecular biology, oncology, hematology, genetic, immunology, cancer biology, cell biology, medical science, disease, pathology, mechanism, study, scientific, Tetraspanin-3, acute myelogenous leukemia, AML, causative factor, blood cancer, leukemia development, Tet3, oncogene, hematopoietic malignancy, leukemia pathology Tetraspanin-3, acute myelogenous leukemia, causative factor, leukemia development, myeloid leukemia, Tetraspanin protein, cancer causation, hematological malignancy Tetraspanin-3, causative, factor, development, acute, myelogenous, leukemia, cancer, blood, disorder, oncogene, proto-oncogene, hematopoietic, stem, cells, mutation, molecular, biology, medical, research, pathology, treatment, prognosis, biomarker, therapeutic, target
1271	The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI. amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI cardiac involvement, amyloidosis, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI
1270	The risk of male prisoners harming themselves is ten times that of female prisoners. male prisoners, female prisoners, self-harm, risk comparison, incarceration, mental health, prison statistics, gender differences, suicidal behavior, institutional safety male prisoners, female prisoners, self-harm, risk comparison, prison health, gender difference, incarceration, mental health, suicide attempts, penal system male prisoners, female prisoners, self-harm, risk, prison, gender differences, incarceration, mental health, suicide, violence male prisoners, self-harm, female prisoners, risk comparison, prison health, gender differences, incarceration, mental health, suicidal behavior, violent behavior male prisoners, female prisoners, self-harm, risk, prison, gender differences, incarceration, mental health, suicide, violence
163	Bariatric surgery has a positive impact on mental health. Bariatric surgery, mental health, positive impact, weight loss surgery, psychological benefits, obesity treatment, mood improvement, anxiety reduction, depression alleviation, self-esteem enhancement bariatric surgery, mental health, positive impact, psychological benefits, weight loss surgery, improved mood, reduced depression, anxiety reduction, quality of life, obesity treatment, post-surgery outcomes bariatric surgery, mental health, positive impact, weight loss, psychological benefits, improved quality of life, depression reduction, anxiety improvement, self-esteem enhancement bariatric surgery, mental health, positive impact, weight loss, psychological benefits, health improvement, obesity treatment, mood enhancement, quality of life, post-surgery outcomes bariatric surgery, mental health, positive impact, weight loss, psychological benefits, improved mood, reduced anxiety, depression treatment, obesity surgery, health outcomes, patient satisfaction
1029	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes. Interleukin-2, Regulatory T cells, Responsiveness, Autoimmune diseases, Type 1 Diabetes, Resistance, Immunology, Cytokine signaling, T-cell function, Autoimmunity interleukin-2, regulatory T cells, autoimmune diseases, Type 1 Diabetes, resistance, responsiveness, immune system, cytokine signaling, T-cell function, autoimmunity, diabetes mellitus, immunology, medical research, cellular immunity Reduced responsiveness, Interleukin-2, Regulatory T cells, Greater resistance, Autoimmune diseases, Type 1 Diabetes interleukin-2, regulatory T cells, autoimmune diseases, Type 1 Diabetes, reduced responsiveness, resistance, immune response, cytokine signaling, T cell function, autoimmunity, diabetes mellitus, immune tolerance interleukin-2, regulatory T cells, autoimmune diseases, Type 1 Diabetes, resistance, reduced responsiveness
960	Polymeal nutrition reduces cardiovascular mortality. Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, study, research, benefits, food, components, intake, impact, clinical, trials, evidence, reduction, risk, factors polymeal, nutrition, cardiovascular, mortality, health, diet, research, benefits, prevention, heart, disease, food, longevity, medical, study, intervention, epidemiology, public, risk, factors, reduction, clinical, trials, evidence, scientific, article, review, meta-analysis polymeal, nutrition, cardiovascular, mortality, heart, health, diet, food, prevention, study, research, benefits, risk, reduction, clinical, trial, evidence, intervention, public, health, lifestyle,变得更健康, 饮食改善, 心血管疾病, 预防措施, 营养餐, 生活方式改变 Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, medicinal, food, study, benefits, risk, reduction, heart, disease, impact, research, evidence,-complementary, therapy, lifestyle, improvement, longevity Polymeal, nutrition, cardiovascular, mortality, health, diet, prevention, heart disease, food, longevity
1389	mTORC2 regulates intracellular cysteine levels through xCT inhibition. mTORC2, intracellular cysteine, xCT inhibition, cysteine levels, mTOR complex 2, xCT transporter, amino acid metabolism, redox homeostasis, cellular signaling, protein synthesis regulation mTORC2, intracellular cysteine, xCT inhibition, regulation, amino acid metabolism, cellular signaling, redox homeostasis, cancer metabolism, nutrient sensing, protein synthesis mTORC2, intracellular cysteine levels, xCT inhibition, cysteine metabolism, mTOR signaling, amino acid transport, cellular regulation, redox homeostasis, cancer metabolism, nutritional sensing mTORC2, cysteine, intracellular levels, xCT inhibition, regulation, amino acid metabolism, signaling pathways, cellular regulation, protein complexes, cysteine transport, oxidative stress, cellular homeostasis mTORC2, cysteine, xCT, inhibition, regulation, intracellular, levels, amino acid, signaling, transport, metabolism
1146	Teaching hospitals do not provide better care than non-teaching hospitals. teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, medical schools, residency programs, healthcare services teaching hospitals, non-teaching hospitals, patient care, healthcare quality, medical education, hospital outcomes, treatment effectiveness, clinical training, medical students, physician training Teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, physician training, healthcare disparities, medical research teaching hospitals, non-teaching hospitals, healthcare quality, hospital care, medical education, patient outcomes, healthcare comparison, medical training, clinical care, hospital performance teaching hospitals, non-teaching hospitals, healthcare quality, patient care, medical education, hospital performance, clinical outcomes, healthcare services, medical training, patient safety
1024	Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes. Recurrent mutations, CTCF anchor sites, oncogenes, genomic instability, cancer genomics, DNA binding, transcriptional regulation, genetic alterations, chromatin structure, tumor development Recurrent mutations, CTCF anchor sites, oncogenes, genetic alterations, cancer genomics, chromatin insulators, transcription factor binding sites, genomic instability, cancer driver mutations, DNA regulatory elements recurrent mutations, CTCF anchor sites, oncogenes, genetic mutations, chromatin insulators, cancer biology, gene regulation, genomic instability, DNA-binding proteins, tumor suppressors Recurrent mutations, CTCF anchor sites, oncogenes, genomic instability, cancer development, transcription factor binding sites, genetic alterations, tumor suppressor genes, chromatin structure, DNA regulatory elements Recurrent mutations, CTCF anchor sites, oncogenes, genetic alterations, cancer genomics, epigenetic regulation, transcription factor binding sites, chromatin structure, genomic instability, tumor development
1266	The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer. breast cancer, parous women, placental weight, premenopausal, risk factors, pregnancy outcomes, cancer association, reproductive health, epidemiology, oncology breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, obstetric history, reproductive factors, hormone levels, epidemiology breast cancer, parous women, placental weight, premenopausal breast cancer, pregnancy risk, cancer association, reproductive factors breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk factors, maternal health, oncology, reproductive health, epidemiology breast cancer, parous women, placental weight, pregnancies, premenopausal breast cancer, risk association
721	Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls. Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, control group, autoimmune response, experimental model, microbial influence, immunology research, disease progression Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, controls, autoimmunity, microbiome, lupus, antibodies, mouse model, bacterial infection, immune response Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, control group, autoimmunity, microbiome, disease model, immune response Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, comparison, controls Lupus-prone mice, curliproducing bacteria, autoantibody titers, infection, controls, autoimmune response, microbial influence, disease progression
1144	Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India. Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, public health, policy evaluation, economic measures, health outcomes, beverage taxes, diabetes prevention, dietary impacts, government intervention, health economics Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, health policy, public health intervention, beverage taxes, diabetes prevention, economic measures, health outcomes, nutritional epidemiology Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, health policy, public health, economic measures, beverage taxes, health outcomes Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, health policy, public health, economic measures, diabetes prevention, beverage taxes, health outcomes, nutritional epidemiology Taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, policy impact, public health, beverage taxes, diabetes prevention, health outcomes
723	Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions. Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, inflammation regulation, raft-mediated signaling, neutrophil activation, immune cell migration Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, signaling pathways, leukocyte trafficking, inflammation regulation, immune cell activation Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, signaling pathways, leukocyte trafficking, immunology, inflammation regulation Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cellular organization, signaling pathways, raft regulation, inflammation, immune cells, migration regulation, cellular functions Ly49Q, neutrophil migration, inflammation sites, membrane raft functions, immune response, cell signaling, leukocyte trafficking, inflammatory response, membrane microdomains, protein-lipid interactions
845	Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils. Neutrophil extracellular traps, NETs, ANCA-stimulated, neutrophils, immune response, inflammation, autoimmunity, NETosis, neutrophil activation, vascular disease, microbial trapping, host defense Neutrophil extracellular traps, NETs, ANCA, ANCA-stimulated, neutrophils, release, immune response, autoimmunity, inflammation, neutrophil activation Neutrophil extracellular traps, NETs, ANCA-stimulated, neutrophils, ANCA, release, immune response, inflammation, autoimmune diseases, NETosis Neutrophil extracellular traps, NETs, ANCA, stimulated neutrophils, autoimmunity, inflammation, neutrophil activation, NETosis Neutrophil extracellular traps, NETs, ANCA, ANCA-stimulated, neutrophils, immune response, inflammation, autoimmunity
967	Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation. Arp2/3, CK-666, pretreatment, lamelliopodia, formation, inhibitor, cell, migration, actin, polymerization Arp2/3, CK-666, lamelliopodia, formation, pretreatment, inhibitor, cell, migration, cytoskeleton, actin, dynamics, signaling, pathways Arp2/3, CK-666, pretreatment, lamelliopodia, formation, inhibitor, cellular, migration, actin, polymerization Arp2/3, inhibitor, CK-666, lamelliopodia, formation, pretreatment, cell, migration, actin, cytoskeleton Arp2/3, CK-666, lamelliopodia, formation, pretreatment, inhibitor, cell, migration, actin, polymerization
847	New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations. new drugs, tuberculosis, necrotic portion, lesion, high concentrations, treatment efficacy, drug penetration, pharmacokinetics, pulmonary tuberculosis, infected tissues new drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacology, medical research, infectious diseases new drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacokinetics, drug delivery, antibiotic resistance, medical research, clinical trials, infectious diseases, lung health, microbiology, bioavailability, therapeutic efficacy, pharmaceutical development New drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacokinetics, medical research, drug delivery, infectious diseases, microbiology, healthcare innovation New drugs, tuberculosis, necrotic portion, lesion, high concentrations, penetration, treatment, pharmacology, medical research, drug efficacy, TB therapy, antimicrobial agents, lung disease, infectious disease, granuloma, drug delivery, therapeutic approach
727	Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts. Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, counterparts, comparison Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, counterparts, immune response, cytokine production, macrophages, differentiation, activation, inflammation, leukocytes, innate immunity, blood cells, immune cells, cellular immunity, phenotypes, inflammation regulation, immune system, myeloid cells, biological processes, cytokine expression, immune modulation, cellular function, leukocyte subsets, functional differences, immune activation, cytokine secretion, cellular differentiation, inflammatory response, immune cell subsets, cellular biology, immunology, molecular biology, cell biology, inflammation biology, immune profiling, cytokine Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune response, cytokine production, inflammation regulation Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, counterparts Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, counterparts
728	Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes. Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune response, cytokine production, phagocytosis, gene expression, cellular function, immune cells, inflammation, immune system, myeloid cells, circulating monocytes, tissue infiltration, macrophage differentiation, cardiovascular disease, atherosclerosis, metabolism, cytokines, chemokines, innate immunity, adaptive immunity, cellular signaling, physiological response, experimental models, human monocytes, mouse monocytes, immunology, cell biology, inflammation regulation, monocyte subsets, immune regulation, cytokine release, immune activation Ly6C, monocytes, inflammatory, capacity, lower, hi, lo, comparison, immune, response, cells, biology, inflammation, research, science, immunology, medical, blood, cytokines, expression, levels, markers, phenotypes, circulating, tissue, resident, activation, signaling, pathways, disease, models, human, mouse, differentiation, function, trafficking, adhesion, migration, phagocytosis, cytokine, production, innate, immunity, adaptive, immunity, inflammation, regulation, macrophages, neutrophils, dendritic, cells, T-cells, B-cells, lymph Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune response, cytokine production, inflammation, hematopoietic cells, mouse model, human monocytes, subsets, differentiation, activation, signaling pathways, immune regulation, disease models, infection, inflammation resolution Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immune cells, inflammation, response, cytokine, expression, differentiation, activation, macrophages, leukocytes, blood, circulation, tissue, resident, immune system, biology, research, study, experiment, cellular, signaling, pathways, disease, association, marker, phenotype, function, regulation, tolerance, therapy, target, treatment, discovery, mechanism, interaction, environment, genetics, epigenetics, proteomics, transcriptomics, bioinformatics, analysis, data, visualization, model, animal, human, clinical, Ly6C, monocytes, inflammatory, capacity, Ly6C hi, Ly6C lo, comparison, immunology, cytokine, expression, inflammation, cells, immune, response, differentiation, activation
729	Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway. Lymphadenopathy,knockin,mouse,SHP-2,MAPK,pathway,genetic,mutation,immunology,molecular,biology,protein,signaling,deficiency,disease,model,phenotype,biology,research,science lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, genetic deficiency, immune response, signaling pathway, mouse model, lymph node, protein tyrosine phosphatase, mitogen-activated protein kinase Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, genetic modification, mouse model, immunodeficiency, signaling pathway, protein phosphatase, tyrosine phosphatase lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, deficiency, mouse model, immunodeficiency, signaling pathway, lymph node, mutation lymphadenopathy,knockin,mouse,SHP-2,MAPK,pathway,deficiency,immunology,molecular biology,gene knockout,protein signaling,lymph nodes,inflammation,genetic disorder,cellular pathway,disease model,biomedical research
1163	The DdrB protein from Deinococcus radiodurans is an alternative SSB. DdrB, Deinococcus radiodurans, alternative SSB, single-strand binding protein, DNA repair, radiation resistance, bacterial proteins, molecular biology, genetics, genomics, proteomics, biochemistry, microbial genetics, extremophiles, single-stranded DNA binding, SSB protein function, protein structure, protein function, DNA protection, DNA replication, DNA recombination, cellular response to DNA damage, genetic stability, microbial physiology, radiation biology, stress response, bacterial adaptation, genetic adaptation, protein-protein interactions, nucleoprotein complexes, DNA metabolism, genomic stability, cellular defense mechanisms, molecular mechanisms of DNA DdrB, Deinococcus radiodurans, alternative SSB, single-strand binding protein, radiation resistance, DNA repair, genomic stability, protein function, microbial biology, molecular genetics DdrB, Deinococcus radiodurans, alternative SSB, single-strand binding protein, radiation resistance, DNA repair, microbial genetics, protein function, molecular biology DdrB, Deinococcus radiodurans, alternative SSB, single-strand binding protein, radiation resistance, DNA repair, bacterial proteins, genetic material protection, extremophile microorganisms DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, alternative SSB, radiation resistance, DNA repair, genetic stability, microbial genetics, molecular biology, protein function
1041	Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes. histone H2A, H2A.Z, gene activation, yeasts, nucleosomes, +1 nucleosome, chromatin remodeling, transcription regulation, histone replacement, epigenetic regulation histone, H2A, H2A.Z, gene, activation, yeast, nucleosomes, +1, stabilization, replacement, slows, epigenetics, chromatin, transcription, regulation histone, H2A, H2A.Z, gene, activation, yeasts, stabilizing, nucleosomes, +1, replacement, slows histone, H2A, H2A.Z, gene, activation, yeast, nucleosomes, +1, stabilization, replacement, slows, transcription, chromatin, epigenetic, regulation histone, H2A, H2A.Z, gene, activation, yeasts, stabilizing, nucleosomes, +1, replacement, slows, chromatin, transcription, regulation
171	Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). Basophils, disease, development, patients, systemic lupus erythematosus, SLE, counteract, inflammation, immune response, autoimmune disease Basophils, disease, development, patients, systemic lupus erythematosus, SLE, counteract, immune response, inflammation, autoimmune diseases Basophils, disease, development, patients, systemic lupus erythematosus, SLE, counteract, immune response, inflammation, autoimmune disease Basophils, disease, counteract, development, patients, systemic lupus erythematosus, SLE, immune response, inflammation, autoimmune disease, treatment, pathogenesis, cellular mechanisms, clinical outcomes Basophils, counteract, disease, development, patients, systemic lupus erythematosus, SLE, immunology, inflammation, autoimmune disorders, treatment, pathology, medical research, clinical studies, immune response, cytokines, leukocytes, therapeutic targets
1282	Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence. Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Condition, Medical Treatment, Off-label Use Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Condition, Medical Therapy, Clinical Evidence, Off-Label Use, Dermatological Treatment Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Disease, Medical Therapy, Evidence-Based Medicine, Off-Label Use, Clinical Application Therapeutic, Dapsone, Pyoderma, Gangrenous, Anecdotal, Evidence, Treatment, Drug, Skin, Condition, Medical, Usage, Research, Studies, Effectiveness Dapsone, Pyoderma Gangrenosum, Therapeutic Use, Anecdotal Evidence, Drug Treatment, Skin Condition, Medical Therapy, Clinical Observation
1281	The ureABIEFGH gene cluster is induced by nickel (II) ion. ureABIEFGH, gene, cluster, induced, nickel, ion, Ni2+, metal, response, regulation, expression, bacteria, microbial, genetics, biochemistry, induction, environmental, stress, metalloproteins, transcription, factors ureABIEFGH, gene, cluster, induced, nickel, ion, Ni2+, metal, bacteria, genetic, regulation, expression, nickel-responsive, microbial, genomics ureABIEFGH, gene, cluster, nickel, ion, induction, metal, regulation, bacterial, response, environment, expression, genetics, microbiology ureABIEFGH, gene, cluster, induced, nickel, ion, Ni2+, regulation, metal, response, bacterial, genetics, molecular, biochemistry ureABIEFGH, gene, cluster, induced, nickel, ion, Ni2+, metal, regulation, genes, induction, microbiology, biochemistry, genetic, expression, metal ions, bacterial genetics, nickel-responsive, operon, gene expression, metal-induced, microbial genetics, nickel regulation
294	Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae. crossover, hotspots, gene, promoters, Saccharomyces, cerevisiae, genetics, molecular, biology, yeast, recombination, meiosis, DNA, chromosome, genomics, eukaryotes, cell, cycle, genetic, mapping, biological, processes, regulatory, sequences, transcription, factors, chromosome, structure, mutations, genetic, variation, evolutionary, biology, sexual, reproduction, heredity, genetic, linkage, population, genetics, biochemistry, biotechnology, genetic, engineering, chromosomal, aberrations, genetic, disorders, genetic, markers, genetic, inheritance, patterns, Mendelian, Crossover, hot spots, gene promoters, Saccharomyces cerevisiae, genetic recombination, yeast genetics, molecular biology, genetic mapping, meiosis, DNA repair Crossover, hot spots, gene promoters, Saccharomyces cerevisiae, meiosis, recombination, genetics, yeast, molecular biology, DNA repair, chromosomal crossover, genetic linkage, genome stability crossover hot spots,gene promoters,Saccharomyces cerevisiae,recombination,molecular biology,yeast genetics,DNA recombination,molecular genetics,yeast genome,genetic recombination Crossover, hot spots, gene promoters, Saccharomyces cerevisiae, meiosis, genetic recombination, yeast, molecular biology, genetics, DNA repair, chromosome segregation, synaptonemal complex, genetic mapping, recombination frequency, crossing-over, meiotic recombination, recombinational repair, genetic linkage, cytogenetics, genomics, bioinformatics, gene regulation, chromatin structure, transcription factors, epigenetics, DNA replication, mutagenesis, strand exchange, homologous recombination, non-homologous end joining, telomeres, centromeres, genetic disorders, evolutionary biology
1280	The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG. ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, bacterial, enzyme, nitrogen, metabolism, metalloenzymes, prokaryotes, nickel, zinc, catalysis ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, microbial, enzymes, nitrogen, metabolism ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, bacterial, enzymes, nitrogen, metabolism, ammonia, production, regulation, assembly, molecular, biology, genetics, microbiology ureABIEFGH, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, gene, cluster, encoding, microbial, metabolism, nitrogen, cycling, enzyme, biogenesis, prokaryotes, biochemical, pathways ureABIEFGH, gene, cluster, urease, maturation, proteins, UreD, UreH, UreE, UreF, UreG, bacterial, enzyme, biosynthesis, molecular, biology, genetics, microbiology, metabolism, nitrogen, cycling
295	Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis. dendritic cells, innate lymphoid cells, crosstalk, immune regulation, intestinal homeostasis, immune cells interaction, gut immunity, inflammatory response, mucosal immunity, cell signaling, immune system, cytokine production, tissue repair, barrier function, host defense, microenvironment, immunology, cell biology, inflammatory diseases, gastrointestinal tract, immune homeostasis, cellular communication, innate immunity, adaptive immunity, cell activation, cell differentiation, immune response modulation, host-microbe interaction, immune tolerance, intestinal inflammation, epithelial barrier, immune cell collaboration, immune network, immune balance, tissue homeostasis, regulatory mechanisms, dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, immune regulation, gut immunity, cell communication, mucosal immunity, immune cells interaction, ILCs, DCs, intestinal inflammation, immune homeostasis, lymphoid tissue, cytokine signaling dendritic cells, innate lymphoid cells, crosstalk, intestinal homeostasis, immune regulation, mucosal immunity, cytokine signaling, immune cell interaction, gut-associated lymphoid tissue, inflammation modulation dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, immune regulation, gut immunity, cell communication, mucosal immunity, inflammation, tissue repair dendritic cells, innate lymphoid cells, intestinal homeostasis, crosstalk, regulation, immune system, gut immunity, cell communication, mucosal immunity, inflammation
298	Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis. cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cellular death, mitochondria, protein release, cell signaling, programmed cell death, biochemistry cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondria, signaling, biochemistry, cell biology, molecular biology cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, protein release, mitochondria, intracellular signaling, apoptosis signaling, caspase activation cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondrial release, caspase activation, intrinsic pathway, apoptosis signaling, cellular stress response cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cell death, mitochondria, protein release, apoptotic pathway
179	Birth-weight is positively associated with breast cancer. birth-weight, breast cancer, positive association, risk factor, health outcome, epidemiology, medical research, cancer studies, weight at birth, oncology, women's health, public health, statistics, clinical studies, health sciences birth-weight, breast cancer, positive association, risk factor, health outcomes, maternal health, infant health, epidemiology, oncology, reproductive health birth-weight, breast cancer, positive association, risk factor, epidemiology, oncology, maternal health, pediatric oncology, cancer prevention, health outcomes birth-weight, breast cancer, positive association, risk factor, health correlation, medical research, epidemiology, women's health birth-weight, breast cancer, positive association, cancer risk, weight at birth, health outcomes, epidemiology, medical research, oncology, reproductive health
971	Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2, grade 2 neoplasia, cervical screening methods, HPV testing, cytology screening, cancer detection, neoplasia detection, cervical health, gynecological cancer, preventive medicine cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2 primary, cervical, cancer, screening, HPV, detection, longitudinal, sensitivity, conventional, cytology, cervical, intraepithelial, neoplasia, grade, 2 cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2, neoplasia detection, HPV screening, cytology screening cervical cancer, HPV detection, primary screening, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, cancer screening methods, HPV testing, cytology screening
1279	The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events. cancer, co-IR, blockade, treatment, adverse, autoimmune, events cancer treatment, co-IR blockade, adverse events, autoimmune reactions, patient safety, immunotherapy complications cancer, patients, co-IR, blockade, adverse, autoimmune, events, treatment cancer treatment, co-IR blockade, adverse autoimmune events, cancer patients, immune checkpoint inhibitors, autoimmunity, oncology, immunotherapy side effects cancer treatment, co-IR blockade, adverse events, autoimmune reactions, immunotherapy, patient care, medical complications, oncology, autoimmunity
1278	The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events. cancer patients, co-IR blockade, adverse autoimmune events, treatment safety, immunotherapy, clinical outcomes, autoimmune reactions, patient care, medical research, oncology treatment cancer treatment, co-IR blockade, adverse autoimmune events, immunotherapy, patient safety, clinical outcomes, autoimmune reactions, cancer immunology, therapy side effects, medical research cancer, patients, co-IR, blockade, treatment, adverse, autoimmune, events, safety, immunotherapy, clinical, trials, research, medicine, oncology cancer treatment, co-IR blockade, adverse effects, autoimmune events, patient safety, immunotherapy, clinical trials, drug side effects, oncology, immune checkpoint inhibitors cancer, treatment, co-IR, blockade, adverse, autoimmune, events, patients, immunotherapy, safety, clinical, trials, oncology, immune, response, side, effects, health, care, research, medicine
852	Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment. Non-invasive ventilation, inadequate response, conventional treatment, decrease usage, respiratory therapy, clinical guidelines, patient management, ventilatory support, treatment efficacy, clinical outcomes Non-invasive ventilation, inadequate response, conventional treatment, decrease usage, respiratory therapy, clinical guidelines, patient management, ventilation strategies, treatment efficacy, medical intervention non-invasive ventilation, inadequate response, conventional treatment, decrease usage, respiratory therapy, clinical guidelines, patient management, ventilation strategies non-invasive ventilation, inadequate response, conventional treatment, ventilation reduction, treatment efficacy, respiratory therapy, patient response, ventilatory support, medical guidelines, clinical outcomes Non-invasive ventilation, conventional treatment, inadequate response, decrease usage, respiratory therapy, clinical guidelines, treatment efficacy, patient outcomes
975	Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators. primary, pro-inflammatory, cytokines, induce, secondary, mediators, anti-inflammatory, inflammation, cytokine-network, immune-response Primary cytokines, pro-inflammatory cytokines, secondary mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, immune response, cytokine signaling, inflammation regulation, immune regulation primary cytokines, pro-inflammatory, secondary mediators, anti-inflammatory, cytokine induction, inflammatory response, immune regulation primary, pro-inflammatory, cytokines, induce, secondary, pro-inflammatory, anti-inflammatory, mediators, cytokine, inflammation, immune, response, signaling, pathways, cell, communication, immune-mediated, diseases, therapy, regulation, expression, modulation, inflammatory, processes, molecular, mechanisms Primary cytokines, pro-inflammatory, secondary mediators, anti-inflammatory, cytokine induction, inflammatory response, mediators regulation, immune system, inflammation signaling
613	Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits. Increased microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, Parkinson's disease, neurodegeneration, molecular biology, neuroscience, motor function, therapeutic targets, protein modifications, cellular mechanics, disease mechanisms, genetic disorders, movement disorders, neurological disorders, acetlyation effects, LRRK2 protein, neuroprotective mechanisms microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, cellular repair, motor function, neurological disorders, protein modification microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, Parkinson's disease, neurodegeneration, cellular repair, motor function, protein function, gene expression, therapeutic targets microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson's disease, cellular repair mechanisms, motor function improvement, biomolecular research, therapeutic targets microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, Parkinson's disease, neurodegeneration, cellular repair, motor function, protein modification, therapeutic targets
70	Activation of PPM1D suppresses p53 function. PPM1D, p53, activation, suppression, function, protein, phosphorylation, oncogene, tumor, suppressor PPM1D, p53, activation, suppression, function, oncogene, tumor, protein, signaling, pathway PPM1D,p53,activation,suppression,function,inhibition,protein,phosphatase,oncogene,tumor,suppressor,cancer,biology,cell,mechanism,pathway PPM1D, p53, activation, suppression, function, protein, phosphorylation, tumor, suppressor, oncogene PPM1D, p53, activation, suppression, function, cancer, DNA damage, cell cycle, apoptosis, oncogene, tumor suppressor, signal transduction, mutation, phosphorylation, therapeutic target
72	Activator-inhibitor pairs are provided dorsally by Admpchordin. activator-inhibitor, pairs, dorsal, Admp, chordin, BMP, signaling, development, patterning, embryo activator-inhibitor, pairs, dorsally, Admp, chordin, signaling, development, patterns, biology, molecular, genetics activator-inhibitor, pairs, dorsal, Admp, chordin, gene-expression, development, dorsoventral-axis, patterning, signaling-molecules, BMP, TGF-beta, embryogenesis Activator-inhibitor, Admp, Chordin, Dorsal, Patterning, Development, Morphogenesis, Signaling, Embryology, Gene-expression activator-inhibitor, pairs, dorsally, Admp, chordin, developmental, biology, signaling, molecules, embryo, morphogenesis
859	Normal expression of RUNX1 has tumor-promoting effects. RUNX1, normal expression, tumor-promoting, effects, oncogene, leukemia, cellular proliferation, gene regulation, cancer, molecular biology RUNX1, tumor-promoting, normal-expression, gene-expression, oncogene, hematopoiesis, leukemia, cancer-biology, transcription-factor, cellular-proliferation RUNX1, tumor-promoting, normal-expression, oncogene, hematopoiesis, transcription-factor, cancer-biology, gene-regulation, molecular-oncology, cell-proliferation RUNX1, normal expression, tumor-promoting, cancer, gene expression, oncogene, hematopoiesis, leukemia, molecular biology, cellular biology RUNX1, tumor-promoting, normal-expression, gene-expression, oncogene, leukemia, cancer-biology, molecular-biology, transcription-factor, cell-proliferation
619	Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments. vessel density, fibrosis reduction, chemotherapy efficacy, treatment outcomes, vascular changes, tumor microenvironment, drug resistance, medical oncology, cancer therapy, angiogenesis increased vessel density, reduction in fibrosis, chemotherapy efficacy, angiogenesis, tumor microenvironment, cancer treatment, vascular remodeling, fibrotic response, drug delivery, tumor biology increased vessel density, reduction fibrosis, chemotherapy efficacy, angiogenesis, tumor microenvironment, cancer treatment outcomes, vascular normalization, fibrotic response, drug delivery impairment, oncology research increased vessel density, reduction in fibrosis, chemotherapy efficacy, tumor vasculature, cancer treatment outcomes, angiogenesis, fibrosis reduction, therapy resistance vessel density, fibrosis, chemotherapy efficacy, tumor microenvironment, angiogenesis, cancer treatment outcomes
75	Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. H. pylori, urease, polymeric structure, UreA, UreB, active enzyme, subunits, protein structure, catalytic activity H. pylori, urease, polymeric structure, UreA, UreB, active enzyme, subunits, protein structure, bacterial enzymes H. pylori, urease, polymeric structure, UreA, UreB, active enzyme, protein subunits, bacterial enzyme H. pylori, urease, polymeric structure, subunits, UreA, UreB H. pylori, urease, polymeric structure, subunits, UreA, UreB, active enzyme, protein complex
1175	The PPR MDA5 has two N-terminal CARD domains. PPR, MDA5, N-terminal, CARD, domains, innate immunity, pattern recognition receptors, antiviral signaling PPR, MDA5, N-terminal, CARD, domains, immune, signaling, protein, structure, function PPR, MDA5, N-terminal, CARD, domains, innate immunity, signaling, receptor, antiviral response PPR MDA5, N-terminal, CARD domains, antiviral signaling, innate immunity, RNA sensing PPR, MDA5, N-terminal, CARD, domains, immune, signaling, protein, structure, function
180	Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction TDP-43, respiratory complex I, ND3, ND6, neuronal loss, interaction blocking, neurodegeneration, mitochondria, protein-protein interaction, ALS, motor neuron disease TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration, mitochondrial dysfunction, ALS, frontotemporal dementia TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, blocking interaction, neurodegeneration
183	Bone marrow cells contribute to adult macrophage compartments. bone marrow, cells, adult, macrophage, compartments, contribution, hematopoiesis, innate immunity, tissue resident macrophages, monocytes Bone marrow, cells, contribute, adult, macrophage, compartments, hematopoiesis, immune system, tissue resident, monocytes, differentiation, inflammation, regeneration, tissue repair bone marrow, cells, contribute, adult, macrophage, compartments, hematopoiesis, immune system, tissue resident macrophages, differentiation, cytokines, microenvironment, stem cells, myeloid cells, organ function, inflammation, repair, development bone marrow, cells, adult, macrophage, compartments, contribution, hematopoiesis, immune system, tissue-resident macrophages, lineage tracing, myeloid cells bone marrow, cells, adult, macrophage, compartments, contribution, hematopoiesis, monocytes, tissue-resident, immune system
1292	There is no association between HNF4A mutations and diabetes risks. HNF4A, mutations, diabetes, risks, association, genetic, study, research, health, insulin, glucose, metabolism, endocrinology, medical, science, genetics, disorder, type 2 diabetes, variant, polymorphism, clinical, analysis, biomarker, disease, prevalence, population, healthcare, molecular, biology, cellular, function, impact, evidence, review, article, publication, statistics, epidemiology, correlation, causality, prevention, treatment, therapy, drug, response, prognosis, outcome, risk factors, environmental, lifestyle, diet, exercise, obesity, age, gender, ethnicity, comorbid HNF4A, mutations, diabetes, risks, association, genetic, endocrinology, metabolic diseases, insulin resistance, beta-cell function HNF4A, mutations, diabetes, risks, association, genetic, study, research, medical, health HNF4A, mutations, diabetes, risks, association, genetic, study, research, health, endocrinology HNF4A, mutations, diabetes, risks, association, genetic, endocrinology, research, study, medical, health, insulin, glucose, metabolism
185	Breast cancer development is determined exclusively by genetic factors. Breast cancer, genetic factors, hereditary, BRCA1, BRCA2, mutation, genetic predisposition, oncogenes, tumor suppressor genes, inherited cancer syndromes, molecular genetics, cancer genomics, genetic testing, familial breast cancer, epigenetics, gene-environment interaction genetic factors, breast cancer, development, hereditary, genetic predisposition, non-genetic factors, environmental influences, cancer risk, genetic mutations, breast cancer genetics breast cancer, genetic factors, development, exclusive determination, hereditary, oncogenes, tumor suppressor genes, genetic predisposition, familial risk, molecular genetics Breast cancer, genetics, hereditary factors, genetic predisposition, development, exclusivity, non-environmental, biological determinants Breast cancer, genetic factors, hereditary, mutation, BRCA1, BRCA2, familial risk, cancer genetics, genetic predisposition, oncogenes, tumor suppressor genes
1290	There is an inverse relationship between hip fractures and statin use. hip fractures, statin use, inverse relationship, bone health, cholesterol lowering drugs, fracture risk, cardiovascular medications, osteoporosis, elderly health, medication benefits hip fractures, statin use, inverse relationship, bone health, cholesterol lowering drugs, osteoporosis, fracture risk, medication effects hip fractures, statin use, inverse relationship, bone health, cholesterol medication, osteoporosis, fracture risk, cardiovascular drugs hip fractures, statin use, inverse relationship, statins, bone health, fracture risk, cardiovascular drugs, osteoporosis, cholesterol lowering drugs, medication effects hip fractures, statin use, inverse relationship, pharmacology, osteoporosis, cholesterol lowering drugs, bone density, elderly health, medication effects, fracture prevention
1049	Ribosomopathies have a low degree of cell and tissue specific pathology. ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, molecular-genetics, disease-mechanisms Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, genetic-disorders, ribosomal-proteins, medical-research, cellular-dysfunction, tissue-damage Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, disease-mechanisms, genetic-disorders, cellular-pathology, tissue-pathology, medical-research, biological-processes Ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, genetic-disorders, molecular-biology, cellular-biology, medical-genetics, ribosomal-proteins, ribosome-biogenesis, disease-mechanisms ribosomopathies, cell-specific, tissue-specific, pathology, low-degree, molecular-biology, genetic-disorders, medical-research, cellular-function, ribosome-disorders
982	Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body. growth cone, proteins, ubiquitination, cell body, synthesis rate, neuronal development, protein degradation, axonal transport, local translation, synaptic plasticity Proteins, growth cone, ubiquitination, cell body, synthesis, rate, neuronal development, molecular biology, protein degradation, neurobiology Proteins, synthesized, growth, cone, ubiquitinated, higher, rate, cell, body Proteins, synthesized, growth, cone, ubiquitinated, higher, rate, cell, body Proteins, synthesized, growth, cone, ubiquitinated, higher, rate, cell, body, neural, development, protein, turnover, axonal, growth, cone, proteasome, neuronal, differentiation
742	Macrolides have no protective effect against myocardial infarction. Macrolides, myocardial infarction, protective effect, antibiotics, heart attack, cardiovascular disease, pharmacology, clinical trials, medication effectiveness Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, drug effectiveness, clinical trials, medical research Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, clinical trials, pharmacology, treatment outcomes Macrolides, myocardial infarction, protective effect, antibiotics, cardiovascular disease, clinical trials, pharmacology, cardiac health, medical research, drug efficacy Macrolides, myocardial infarction, protective effect, pharmacology, cardiovascular disease, clinical trials, antibiotics, heart attack prevention
501	Headaches are not correlated with cognitive impairment. headaches, cognitive impairment, correlation, brain function, neurological disorders, pain management, mental health, clinical research, neurology, psychology headaches,cognitive impairment,correlation,lack of correlation,neurology,brain health,pain management,mental function headaches,cognitive impairment,correlation,lack of correlation,brain function,neurological symptoms,pain and cognition headaches, cognitive impairment, correlation, neurological disorders, brain function, pain management, health studies, medical research, symptom analysis, psychological factors headaches, cognitive impairment, correlation, neurological disorders, brain function, pain management, health studies, medical research, symptom analysis, mental health
743	Macrolides protect against myocardial infarction. Macrolides, myocardial infarction, cardiovascular protection, heart attack prevention, antibiotic therapy, cardiac health, pharmacological intervention, clinical outcomes, drug efficacy, medical research macrolides, myocardial infarction, heart attack, cardiovascular protection, antibiotic therapy, clinical trials, pharmacology, cardiology, treatment outcomes, medical research macrolides, myocardial infarction, heart attack, cardiovascular protection, antibiotic therapy, cardiac health, anti-inflammatory effects, cholesterol reduction, blood pressure management, stroke prevention, cardioprotective drugs, clinical trials, medical research, patient outcomes, healthcare intervention, pharmacology, treatment efficacy, medical guidelines, risk factors, disease prevention Macrolides, myocardial infarction, cardiac protection, antibiotics, heart attack prevention, antimicrobial therapy, cardiovascular health, drug effectiveness, clinical outcomes, pharmaceutical intervention Macrolides, myocardial infarction, cardiac protection, antibiotics, heart disease, anti-inflammatory, bacterial infection, cardiovascular risk, clinical trials, drug efficacy
985	Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy. Pseudogene, PTENP1, PTEN, miRNA, decoy, gene-regulation, expression, molecular-biology, non-coding-RNA, cancer-biology Pseudogene, PTENP1, PTEN, miRNA, decoy, regulation, expression Pseudogene, PTENP1, PTEN, miRNA, decoy, gene-regulation, expression, non-coding-RNA, cancer, tumor-suppressor Pseudogene, PTENP1, PTEN, miRNA, decoy, gene regulation, expression, molecular biology, cancer, genetics Pseudogene, PTENP1, PTEN, miRNA, decoy, regulation, gene expression, miRNA target, non-coding RNA, cancer, tumor suppressor
502	Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements. Healthcare delivery, efficiency, crowded centers, structural improvements, logistical improvements, interpersonal improvements, patient care, resource management, workflow optimization Healthcare, Delivery, Efficiency, Crowded, Centers, Structural, Logistical, Interpersonal, Elements, Improvement Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement, patient, flow, staff, communication, infrastructure, management, technology, coordination, resources, time, quality, care, environment, strategy, policy, training, support, satisfaction, outcomes, optimization, systems, processes, challenges, solutions, impact, research, innovation, best, practices, models, intervention, assessment, evaluation, data, analytics, reporting, feedback, improvement, initiatives, collaboration, teamwork, leadership, culture, change, adaptation, flexibility, resilience, patient-centered, care, seamless, transition, access, availability, Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement, patient, flow, management, staff, communication, infrastructure, space, technology, process, optimization Healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement
623	Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis. vitamin D, serum concentrations, multiple sclerosis, risk, individuals, low levels, neurological disorders, nutritional deficiencies, immune system, health outcomes vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, nutritional deficiencies, immunological diseases, health correlations, medical research, public health studies vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, nutritional deficiencies, immune system disorders vitamin D, serum concentrations, multiple sclerosis, risk factors, individuals, health correlation, deficiency, neurological disorders vitamin D, serum concentrations, multiple sclerosis, risk factors, neurological disorders, vitamin D deficiency, immune system, epidemiology, health outcomes, clinical studies
744	Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein. Macropinocytosis, Amino Acids, Intracellular Uptake, Protein Supply, Cell Nutrition, Endocytosis, Nutrient Acquisition, Cellular Metabolism Macropinocytosis, amino acids, intracellular uptake, protein supply, cell nutrition, endocytosis, cellular metabolism, protein degradation, nutrient acquisition, lysosomal processing macropinocytosis, cell, supply, amino acids, intracellular uptake, protein Macropinocytosis, amino acids, cell supply, intracellular uptake, protein absorption, nutrient intake, cellular nutrition, endocytosis, biomolecular transport, cell biology Macropinocytosis, amino acids, intracellular uptake, protein supply, cell nutrition
507	Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication. Helminths, Immune System, Macrophages, IL-4, Mycobacterium tuberculosis, Replication, Interference, Activation, Bacterial Infection, Parasitic Infection, Immune Response, Pathogenesis, Host-Pathogen Interaction, Cytokines, Immune Modulation, Tuberculosis, Parasitology, Microbiology, Immunology Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, infection, cytokines, host-pathogen interaction, immunity modulation Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation, parasitic infection, tuberculosis, cytokine, immune response, host-pathogen interaction Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation, pathogenesis, host-pathogen interaction, tuberculosis, parasitic infection, cytokine response, immune modulation helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, activation
628	Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin. African origin, HTLV-1, human T-cell lymphotropic virus type 1, infection frequency, viral infection, T-cell infection, epidemiology, geographic distribution, genetic predisposition, virus transmission African origin, HTLV-1, human T-cell lymphotropic virus type 1, infection frequency, viral epidemiology, genetic predisposition, lymphotropic viruses, T-cell infection, viral infections in Africa, HTLV-1 prevalence African origin, human T-cell lymphotropic virus type 1, HTLV-1, infection frequency, viral infection, ethnic predisposition, population genetics, virology, epidemiology human T-cell lymphotropic virus type 1, HTLV-1, African origin, infection frequency, lymphotropic virus, T-cell infection, African population, viral infection, HTLV-1 prevalence, human T-cell virus African origin, human T-cell lymphotropic virus type 1, infection frequency, HTLV-1, genetic predisposition, viral epidemiology, population health studies
508	Hematopoietic Stem Cell purification reaches purity rate of up to 50%. Hematopoietic, Stem, Cell, purification, purity, rate, 50% Hematopoietic, Stem, Cell, Purification, Purity, Rate, 50% Hematopoietic, Stem, Cell, Purification, Purity, Rate, 50% Hematopoietic, Stem, Cell, purification, purity, rate, 50% Hematopoietic, Stem, Cell, Purification, Purity, Rate, 50%
1187	The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription. YAP1, TEAD, nucleus, transcription factors, DNA-binding proteins, target gene transcription, translocation, complex formation, gene regulation, cellular signaling YAP1, TEAD, nucleus, transcription factors, DNA-binding proteins, target gene transcription, translocates, modulate, gene expression, cellular signaling, oncogene, tumor suppressor, Hippo pathway YAP1, TEAD, nucleus, transcription factors, DNA-binding proteins, gene transcription, complex translocation, target genes YAP1, TEAD, nucleus, transcription factors, DNA-binding proteins, target gene transcription, translocation, complex formation, gene regulation, cellular signaling YAP1, TEAD, nuclear translocation, transcription factors, DNA-binding proteins, gene transcription, target genes, cellular signaling, oncogenesis, transcriptional regulation
1185	The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. US health care system, cost savings, kidney transplants, patients, optimized national kidney paired donation program, $750 million, 7% participation US health care system, cost savings, $750 million, kidney transplants, patients, optimized national kidney paired donation program, 7% participation US health care system, cost savings, kidney transplants, patient waitlist, national kidney paired donation program, optimized donation program, healthcare efficiency, transplant medicine, organ donation, healthcare policy US health care system, cost savings, kidney transplants, patients, national kidney paired donation program, optimized program, health care costs, transplant patients, paired donation, medical efficiency US health care system, cost savings, kidney transplants, patients, national kidney paired donation program, optimized program, medical economics, transplant waitlist, health policy, organ donation, health care efficiency
1062	S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases. S-nitrosylated,GAPDH,transnitrosylates,histone,deacetylases,physiological,Nitric,Oxidation,Protein,Modification,Enzyme,Activity,Biochemistry,Molecular,Biology S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, protein, modification, nitric, oxide, signaling S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, physiologically, protein, modification, nitric, oxide, signaling, enzymatic, activity, cellular, function S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, physiological, nitrosylation, protein, modification, enzymatic, activity S-nitrosylated, GAPDH, transnitrosylates, histone, deacetylases, physiological, nitric, oxide, post-translational, modification, protein, interaction, enzymatic, activity, cellular, signaling, epigenetic, regulation
1180	The PRR MDA5 is a sensor of RNA virus infection. PRR, MDA5, RNA, virus, infection, sensor, immune, response, detection, pathogen, recognition, receptor PRR, MDA5, RNA, virus, infection, sensor, immunity, pathogen, recognition, molecular, biology, virology PRR, MDA5, sensor, RNA, virus, infection, detection, immune, response, antiviral, signaling, pathogen, recognition, receptor, innate, immunity PRR, MDA5, RNA, virus, infection, sensor, detection, immunity, innate, response PRR, MDA5, RNA, virus, infection, sensor, immune, response, detection, antiviral
198	CCL19 is absent within dLNs. CCL19, dLNs, absent, lymph nodes, chemokine, CCL19-negative, draining lymph nodes CCL19, dLNs, absence, lymph nodes, chemokine, immune response, tissue distribution, lymph node function, molecular biology, immunology CCL19, dLNs, absent, lymph nodes, chemokine, immunology, absence, detection, research, biology, molecular, signaling, pathway, tissue, expression, absence study, scientific, investigation, medical, health, cells, environment, interaction, response, inflammation, immune system, trafficking, localization, marker, negative, not present, profiling, analysis, technique, method, experiment, laboratory, results, findings, report, publication, article, paper, study, observation, evidence, data, information, reference, source, literature, review, summary, conclusion, interpretation, discussion, impact, significance, CCL19, dLNs, absence, lymph nodes, chemokine, immune response, tissue distribution, mRNA expression, protein level, immunohistochemistry, cellular localization, lymph node microenvironment, inflammatory conditions, immune cell trafficking CCL19, dLNs, absence, lymph nodes, chemokine, immune response, tissue distribution, expression pattern
870	Obesity decreases life quality. Obesity, life quality, health impact, well-being, lifestyle diseases, longevity, mental health, physical health, obesity complications, quality of life, health disorders, weight-related issues Obesity, life quality, health impact, well-being, longevity, lifestyle diseases, metabolic syndrome, physical health, mental health, obesity complications obesity, life quality, health impact, well-being, chronic conditions, lifestyle factors, weight management, mental health, physical health, longevity obesity, life quality, health impact, well-being, longevity, physical health, mental health, lifestyle factors, nutrition, exercise obesity, life quality, health impact, wellbeing, chronic diseases, mental health, physical health, lifespan, quality of life, obesity effects
993	Pyridostatin destabilizes the G - quadruplex in the telomeric region. Pyridostatin, G-quadruplex, telomeric, destabilizes, DNA, telomere, chromosomal, structure, molecular, biochemistry Pyridostatin, G-quadruplex, telomeric, destabilization, nucleic acids, biochemical mechanism, telomeres, DNA structure, chemotherapy, cancer research Pyridostatin, G-quadruplex, telomere, destabilization, nucleic acid structure, telomeric region, DNA stabilization, chemical biology, molecular biology, telomere dynamics Pyridostatin, G-quadruplex, telomeric, destabilization, DNA, telomeres, quadruplex structure, molecular biology, cancer research, nucleic acids, biochemical mechanisms Pyridostatin, G-quadruplex, telomeric, destabilization, telomeres, quadruplex structure, drug interaction, nucleic acid structure, cancer therapy, molecular biology
873	Obesity is determined solely by environmental factors. Obesity, environmental factors, genetics, lifestyle, diet, physical activity, socioeconomic status, public health, nutrition, obesity causes, environmental influence, non-genetic factors obesity, environmental factors, sole cause, genetics, lifestyle, diet, physical activity, socioeconomic status, urbanization, food availability obesity, environmental factors, sole cause, lifestyle, diet, physical activity, genetic predisposition, socioeconomic status, urbanization, food availability, policy, education, obesity epidemic, health behavior, public health干预措施 obesity, environmental factors, diet, physical activity, lifestyle, genetics, socio-economic status, urbanization, fast food, sedentary behavior obesity, environmental factors, genetic factors, lifestyle, diet, physical activity, socioeconomic status, urbanization, food availability, sedentary behavior
1179	The PRR MDA5 has a central DExD/H RNA helices domain. PRR MDA5, DExD/H, RNA helices, central domain, helicase domain, nucleic acid binding, innate immunity, virus sensing PRR MDA5, central domain, DExD/H, RNA helices, protein structure, helicase domain, molecular biology, RNA processing PRR MDA5, central domain, DExD/H, RNA helices, protein structure, molecular biology, helicase domain, RNA processing PRR MDA5, central domain, DExD/H, RNA helices, protein structure, molecular biology, helicase domain, nucleic acid binding PRR MDA5, DExD/H RNA helicase domain, central domain, RNA helicase, PRR protein, MDA5 structure, viral recognition, innate immunity
1298	Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke. thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, reduced, patients, admitted, hospital, immobile, acute, stroke thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, DVT, patients, hospital, immobile, acute, stroke, prevention, effectiveness, medical, treatment, study, research, clinical, trial, outcomes, risk, reduction, healthcare, evidence-based, practice, vascular, circulation, neurological, rehabilitation, immobility, complications, thromboembolism, prophylaxis, anticoagulation, compressive, therapy, stocking, length, graduated-compression, medical-grade, stroke-patients, hospital-acquired, thrombosis-prevention, mobility, recovery, thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, reduction, hospital, immobile, acute, stroke, patients, admitted thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, DVT, hospital, admitted, patients, immobile, acute, stroke, prevention, efficacy, medical, treatment, study, research, clinical, trial, outcomes, evidence, health, care, intervention, risk, reduction, effectiveness thigh-length, graduated, compression, stockings, GCS, deep, vein, thrombosis, reduce, patients, hospital, immobile, acute, stroke
513	High cardiopulmonary fitness causes increased mortality rate. cardiopulmonary fitness, increased mortality, physical activity, cardiovascular health, exercise, longevity, health outcomes, risk factors, mortality rate, fitness level cardiopulmonary fitness, increased mortality, high fitness, mortality rate, fitness mortality, health outcomes, cardiovascular health, physical fitness, longevity, exercise benefits, risk factors, health risks, fitness levels, mortality studies, public health, exercise intensity, cardiovascular exercise, heart health, lifespan, physical activity levels cardiopulmonary fitness, mortality rate, high fitness, increased mortality, fitness mortality correlation, cardiovascular health, physical activity outcomes, health risks, exercise benefits, longevity studies high cardiopulmonary fitness, increased mortality rate, cardiovascular health, physical fitness, longevity, health outcomes, exercise-related risks, fitness paradox, cardiorespiratory endurance, mortality association high cardiopulmonary fitness, increased mortality rate, cardiovascular health, physical fitness, mortality, health outcomes, exercise, cardiorespiratory fitness, longevity, risk factors
514	High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter. High dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, 75 nmol/liter, vitamin D, calcium intake, prevention, nutritional requirements, bone health, parathyroid hormone, clinical nutrition, dietary supplements, mineral metabolism High dietary calcium, prevention, secondary hyperparathyroidism, 25(OH)D levels, 75 nmol/liter, unnecessary, vitamin D, bone health, parathyroid hormone, nutritional requirements high dietary calcium, unnecessary, prevention, secondary hyperparathyroidism, 25(OH)D levels, above 75 nmol/liter, vitamin D sufficiency, calcium metabolism, parathyroid hormone, nutritional recommendations, bone health, mineral balance, clinical nutrition, endocrinology, dietary intake, public health, calcium supplementation, serum vitamin D, hypoparathyroidism prevention, adult nutrition, calcium absorption, renal function, dietary minerals, nutrient interactions dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, nutrient intake, bone health, calcium supplementation, parathyroid hormone, nutritional requirements, clinical nutrition high dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, 75 nmol/liter, unnecessary, prevention, subjects, vitamin D, calcium intake, hyperparathyroidism prevention, vitamin D sufficiency
756	Many proteins in human cells can be post-translationally modified at lysine residues via acetylation. proteins, human cells, post-translational modification, lysine residues, acetylation lysine, acetylation, post-translational, proteins, human, cells, modification, residues, enzymatic, biochemical post-translational modification, lysine residues, acetylation, human cells, proteins, cellular processes, biochemical modifications, protein function, enzymatic regulation lysine, acetylation, post-translational modification, human cells, proteins lysine, acetylation, post-translational modification, proteins, human cells
636	Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate. Inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemistry, phosphoinositide, signaling, pathway inositol lipid, 3-phosphatase, PTEN, Ptdlns(3,4)P2, phosphatidylinositol 4-phosphate, lipid signaling, enzyme activity, phosphoinositide metabolism inositol, lipid, 3-phosphatase, PTEN, Ptdlns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemical, pathway inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, biochemical, reaction, signaling, pathway Inositol, lipid, 3-phosphatase, PTEN, Ptdlns(3,4)P2, phosphatidylinositol, 4-phosphate, conversion, enzyme, signaling, pathway
516	High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD). CRP, chronic obstructive pulmonary disease, COPD, exacerbations, risk reduction, inflammation marker, respiratory disease, blood test, clinical marker, lung disease CRP, COPD, exacerbations, risk reduction, chronic obstructive pulmonary disease, C-reactive protein, respiratory diseases, inflammation markers CRP, COPD, chronic obstructive pulmonary disease, inflammation, risk reduction, exacerbations, pulmonary health, biomarkers, respiratory diseases CRP, chronic obstructive pulmonary disease, COPD, risk reduction, exacerbations, inflammatory markers, respiratory diseases, clinical outcomes, biomarkers, lung health CRP, COPD, chronic obstructive pulmonary disease, inflammation, biomarker, respiratory disease, exacerbations, risk reduction, pulmonary health
637	Input from  mental and physical health care professionals is effective at decreasing homelessness. mental health, physical health, healthcare professionals, effectiveness, homelessness, reduction, intervention, support services, community care, public health mental health, physical health, healthcare professionals, homelessness, effectiveness, intervention, treatment,support services, policy, research, community health, social work, psychology, psychiatry, public health, prevention, recovery, housing stability, client outcomes, evidence-based practices mental health, physical health, healthcare professionals, homelessness, intervention, effectiveness, clinical input, social services, community health, public health strategies mental health, physical health, healthcare professionals, homelessness, effectiveness, intervention, treatment, support services, policy, research mental health, physical health, healthcare professionals, effectiveness, homelessness reduction, interdisciplinary approach, patient care, social determinants of health, community support, preventive care
879	Occupancy of ribosomes by IncRNAs do not make functional peptides. ribosomes, IncRNAs, non-coding RNA, functional peptides, translation, gene expression, molecular biology, RNA function, protein synthesis, cellular processes ribosome, IncRNA, occupancy, functional peptides, non-coding RNA, translational regulation, molecular biology, gene expression ribosomes, IncRNAs, occupancy, functional peptides, non-coding RNA, translation, molecular biology, gene expression, ribosome binding, RNA function IncRNAs, ribosomes, occupancy, non-coding RNAs, functional peptides, translation, molecular biology, gene regulation ribosomes, IncRNAs, occupancy, functional peptides, non-coding RNAs, translation, molecular biology, gene expression, RNA biology
517	High levels of copeptin decrease risk of diabetes. copeptin, diabetes, risk, levels, high, decrease, health, biomarker, endocrinology, prevention copeptin, diabetes, risk, high levels, biomarker, cardiovascular, prognosis, insulin, glucose, metabolism, clinical trials, endocrinology, biomolecular, health outcomes copeptin, diabetes, risk reduction, high levels, biomarker, cardiovascular health, endocrine system, insulin resistance, clinical studies, preventive medicine copeptin, diabetes, risk reduction, high levels, biomarker, health indicator, preventive factor, endocrine studies copeptin, diabetes, risk reduction, high levels, biomarker, cardiovascular health, insulin resistance, metabolic syndrome
759	Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission. Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact reduction, treatment efficacy, public health strategy, disease control Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, treatment impact, disease reduction, public health strategies, infectious diseases, pharmacology, medical research Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact, prediction, treatment efficacy, parasite reduction, public health strategy Artemisinin, combination therapy, nongametocytocidal, drugs, malaria, transmission, reduction, mathematical models, impact, treatment, infectious diseases, parasitology, public health, tropical medicine mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, impact reduction, malaria treatment, public health strategies, infectious disease control
94	Albendazole is used to treat lymphatic filariasis. Albendazole, Lymphatic filariasis, Treatment, Medication, Parasitic infection, Elephantiasis, Drug therapy, Antihelmintic, Nematode, Disease management Albendazole, lymphatic filariasis, treatment, medication, parasitic infection, elephantiasis, filaria, drug therapy, tropical disease, antiparasitic Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, elephantiasis, roundworm infection Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, disease management, infection, tropical medicine, public health, drug therapy Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, health, disease management, tropical medicine, parasitology, infectious diseases
99	Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding Alizarin, hydrogen bonds, residues, PGAM1, substrate binding alizarin, hydrogen bonds, residues, PGAM1, substrate binding
1197	The availability of safe places to study is not effective at decreasing homelessness. safe places, study areas, homelessness reduction, effectiveness, urban planning, public policy, social services, shelter availability, community resources, educational environment safe places, study areas, homelessness reduction, effectiveness, shelter availability, public spaces, community centers, libraries, urban planning, social services safe places, study areas, homelessness reduction, effectiveness, public spaces, shelter availability, urban planning, social services, community resources, housing instability safe places, study, homelessness, effectiveness, reduction, available, shelters, libraries, community centers safe places, study areas, homelessness reduction, effectiveness, public spaces, accessibility, urban planning, social services, shelter alternatives, community resources
1196	The availability of safe places to study is effective at decreasing homelessness. safe places, study areas, homelessness reduction, effective interventions, public spaces, community centers, libraries, youth shelters, affordable housing, urban planning, social services, education access safe places, study areas, decreasing homelessness, effectiveness, public spaces, community centers, libraries, shelters, youth programs, urban planning safe places, study areas, homelessness reduction, effective measures, public spaces, community centers, libraries, youth shelters, support services, urban planning safe places, study areas, decrease homelessness, effective solutions, public spaces, community centers, libraries, youth shelters, adult shelters, mental health support, educational resources, urban planning, social services, policy making, government intervention, non-profit organizations, volunteer opportunities, funding opportunities, research studies, statistical evidence, impact analysis safe places, study areas, homelessness reduction, effective strategies, public spaces, educational environments, social services, community resources, urban planning, housing stability
1194	The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'. TatAd complexes, arm density, structural rearrangements, Class1, charge zipper mechanism arm density, TatAd complexes, structural rearrangements, Class1 TatAd, charge zipper mechanism arm density,TatAd complexes,structural rearrangements,Class1,TatAd,charge zipper mechanism arm density, TatAd complexes, structural rearrangements, Class1 TatAd, charge zipper mechanism TatAd complexes, arm density, structural rearrangements, Class1, charge zipper mechanism
1191	The amount of publicly available DNA data doubles every 10 years. DNA, data, public, availability, doubling, years, genomics, biotechnology, research, growth, exponential, information, genetics DNA, data, doubling, publicly, available, genetics, genomics, information, growth, exponential, science, research, databases, biotechnology DNA,data,publicly,available,growth,rate,doubling,time,genomics,biotechnology,research,statistics,trends DNA, data, public, availability, doubling, years, genetics, genomics, bioinformatics, scientific, research, databases, exponential, growth, information, technology, sequencing, biotechnology DNA, data, publicly, available, doubles, 10, years, exponential, growth, genomics, information, expansion, biotechnology, genetics, research, database, bioinformatics
880	Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs ribosomes, IncRNAs, 5'UTRs, occupancy, mirror, gene expression, RNA biology, molecular biology, transcription, translation, non-coding RNAs, regulatory RNAs IncRNAs, ribosomes, occupancy, 5'UTRs, gene expression, molecular biology, RNA binding, translation regulation ribosomes, IncRNAs, 5'UTRs, occupancy, gene expression, RNA binding, translation regulation, molecular biology, transcriptomics, non-coding RNA ribosomes, IncRNAs, 5'UTRs, occupancy, mirror, gene expression, RNA binding, translation initiation, molecular biology, non-coding RNAs ribosomes, IncRNAs, occupancy, 5'UTRs, gene expression, RNA binding, molecular biology, translational regulation
882	Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians. Omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, metabolism, gut, microbiome, cardiovascular, health, nutrition, study, comparison, biomarker Omnivores, Trimethylamine N-oxide, Dietary I-carnitine, Vegetarians, Metabolism, Nutritional Biochemistry, Diet Comparison, Health Implications, Microbiome Differences omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, metabolism, gut, microbiome, nutrition, health, comparison, study, research, food, science omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, retrieval, query, improvement, keywords omnivores, vegetarians, trimethylamine, N-oxide, dietary, L-carnitine, metabolism, gut, microbiome, health, nutrition
641	Insomnia can be effectively treated with cognitive behavioral therapy. insomnia, cognitive behavioral therapy, treatment, effectively, sleep disorders, therapy, mental health, behavioral interventions Insomnia, Cognitive Behavioral Therapy, Treatment, Sleep Disorders, Psychological Interventions, Therapy Effectiveness, Mental Health Treatments, Non-Pharmacological Interventions insomnia, cognitive behavioral therapy, treatment, sleep disorders, mental health, therapy effectiveness, behavioral interventions, sleep improvement, psychological treatment, non-pharmacological therapy Insomnia, Cognitive Behavioral Therapy, Treatment, Sleep Disorders, Therapy, Mental Health, Effective Treatments, Behavioral Interventions, Sleep Improvement, CBT insomnia, cognitive behavioral therapy, treatment, sleep disorders, psychological therapy, CBT, mental health, sleep improvement, therapy effectiveness, behavioral intervention
521	High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI). High-sensitivity, cardiac, troponin, T, HSCT-T, dosage, diagnostic, onset, symptoms, less, 3, hours, acute, myocardial, injury, AMI HSCT-T, dosage, diagnostic, onset symptoms, acute myocardial injury, AMI, high-sensitivity cardiac troponin T, 3 hours, cardiac biomarker, myocardial infarction, troponin measurement, early diagnosis, clinical assessment, heart attack, biomarker sensitivity, emergency medicine, cardiovascular disease, patient management High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, onset symptoms, less than 3 hours, acute myocardial injury, AMI high-sensitivity, cardiac, troponin, T, HSCT-T, dosage, diagnostic, onset, symptoms, less, than, 3, hours, acute, myocardial, injury, AMI High-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic, onset symptoms, less than 3 hours, acute myocardial injury, AMI
644	Insulin increases risk of severe kidney failure. insulin, risk, severe, kidney, failure, diabetes, medication, health, treatment, complications Insulin, kidney failure, severe, risk, diabetes, renal dysfunction, treatment, glucose management, medication side effects, health complications Insulin, kidney, failure, risk, severe, diabetes, treatment, side, effects, medication, health, complication insulin, severe, kidney, failure, risk, medication, diabetes, renal, dysfunction, health, treatment, side, effects, medical, condition, research, study, pathology, clinical, outcomes Insulin, kidney failure, severe, risk, diabetes, metabolism, health, treatment, medication, nephropathy
887	Only a minority of cells survive development after differentiation into stress-resistant spores. minority cells, survival, development, differentiation, stress-resistant, spores development, differentiation, stress-resistant, spores, survival, minority, cells development, differentiation, stress-resistant, spores, survival, minority, cells development, differentiation, stress-resistant, spores, survival, minority, cells minority, cells, survive, development, differentiation, stress-resistant, spores
525	Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors. Histone demethylase, recruitment, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors histone demethylase, recruitment, transient decrease, histone methylation, ligand-dependent, induction, transcription, nuclear receptors Histone demethylase, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors, chromatin modification, gene expression regulation, nuclear receptor signaling, epigenetic regulation Histone demethylase, transcription, nuclear receptors, ligand-dependent induction, histone methylation, gene regulation, epigenetic modification, cellular signaling, chromatin dynamics, molecular biology, biochemistry, genetics, pharmacology, endocrinology Histone demethylase, recruitment, transient decrease, histone methylation, ligand-dependent induction, transcription, nuclear receptors
768	Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT). Mercaptopurine, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT, anabolism, metabolism, enzymatic conversion, drug activation, pharmacology, biochemistry Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine, methyltransferase, TPMT, pharmacogenomics, enzyme, metabolism, drug, activation, inhibition, genetic, variation, treatment, leukemia, immunosuppression Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine methyltransferase, TPMT, metabolism, enzyme, pharmacology Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine methyltransferase, TPMT
527	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress. Homozygous deletion, murine, Sbds gene, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention, gene expression, stem cell biology, mouse model, genetic modification, cellular stress, mesenchymal progenitor cells Homozygous deletion, murine, Sbds gene, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention Homozygous deletion, murine, Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention Homozygous deletion, Sbds gene, murine, osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, prevention, genetic modification, stem cell research, mouse model, gene expression, cellular stress, molecular biology, genetics Homozygous deletion, murine Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene knockout, stem cell research, mouse model, genetic modification, cellular stress, mesenchymal progenitor cells, osterix expression, Sbds gene function, stem cell biology, genetic engineering, oxidative damage, cellular differentiation, bone marrow stromal cells, genetic disorders, cell signaling, molecular biology, gene expression, stem cell therapy, bone development, skeletal biology, genetic deletions, mesenchymal lineage, Sbds
528	Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax. Human T-lymphotropic virus type-I, HTLV-I, myelopathy, tropical spastic paraparesis, HAM/TSP, patients, Immunoglobulin G, IgG, antibodies, cross-react, immunodominant epitope, Tax protein Human T-lymphotropic virus type-I, HTLV-I, myelopathy, tropical spastic paraparesis, HAM/TSP, Immunoglobulin G, IgG, antibodies, cross-react, immunodominant epitope, Tax protein Human T-lymphotropic virus type-I, HTLV-I, myelopathy, tropical spastic paraparesis, HAM/TSP, Immunoglobulin G, IgG, antibodies, immunodominant epitope, Tax protein, cross-reactivity, neurodegenerative diseases, viral infections, immune response Human T-lymphotropic virus type-I, HAM/TSP, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, immunodominant epitope, Tax protein, cross-reactivity, viral infection, neurodegenerative disease, immune response, antibody production, HTLV-I, myelopathy, spastic paraparesis, epitope recognition, immune system, virology, neurological disorders, medical research, clinical immunology Human T-lymphotropic virus type-I, HAM/TSP, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, immunodominant epitope, Tax protein, viral infection, neurological disorder, immune response, cross-reactivity, antibody production, HTLV-I associated myelopathy, viral epitopes, immune system, pathogenesis, clinical research, medical virology, neuroinflammation
649	Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance classroom-based collaborative learning, Web-based collaborative learning, subpar class performance, integration challenges, educational technology, student engagement, learning outcomes, hybrid learning models, collaborative tools, academic achievement classroom-based collaborative learning, web-based collaborative learning, subpar class performance, educational technology, learning outcomes, student engagement, hybrid learning environments, academic achievement, collaborative tools, online collaboration, face-to-face interaction, digital learning, pedagogical strategies, student performance, learning effectiveness classroom-based collaborative learning, web-based collaborative learning, subpar class performance, integration challenges, educational technology, collaborative learning outcomes, student engagement, digital learning environments, academic achievement, hybrid learning models classroom-based collaborative learning, Web-based collaborative learning, subpar class performance, integration challenges, educational technology, student engagement, learning outcomes, collaborative tools, academic achievement, teaching methods classroom-based collaborative learning, Web-based collaborative learning, subpar class performance, integration of learning methods, educational technology, student performance, blended learning, collaborative learning outcomes
1088	Silencing of Bcl2 is important for the maintenance and progression of tumors. Bcl2, silencing, tumor maintenance, tumor progression, cancer therapy, apoptosis regulation, oncogenes, tumor suppressors Silencing, Bcl2, Maintenance, Tumors, Progression, Cancer, Apoptosis, Oncology, Gene Expression, Therapy, Biomarkers, Molecular Biology Bcl2, silencing, tumor maintenance, tumor progression, oncogene, apoptosis, cancer therapy, molecular targeting, gene expression, tumor biology Bcl2, silencing, tumors, maintenance, progression, cancer, apoptosis, gene-expression, therapy, oncology Bcl2, silencing, tumor maintenance, tumor progression, oncology, apoptosis regulation, cancer therapy, gene expression, molecular biology, cellular processes, therapeutic targets
1086	Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, improvement, treatment, sexual health, antidepressant-induced, erectile dysfunction Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, improvement, treatment, sexual health, pharmacotherapy, antidepressant-induced dysfunction Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, improvement, sexual health, antidepressant-induced dysfunction Sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, treatment, sexual health, pharmacotherapy, antidepressant-induced dysfunction, ED, selective serotonin reuptake inhibitors, medication side effects,勃起功能障碍, 性功能障碍, 抗抑郁药, 选择性5-羟色胺再摄取抑制剂, 药物副作用, 药物治疗, 性健康, 治疗方法 sildenafil, erectile function, men, sexual dysfunction, SSRI antidepressants, treatment, improvement, pharmacotherapy, sexual health, antidepressant-induced dysfunction
770	Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. Metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients Metastatic colorectal cancer, fluoropyrimidines, oxaliplatin, chemotherapy, elderly patients, efficacy, quality of life metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients Metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients
410	Febrile seizures increase the threshold for development of epilepsy. febrile, seizures, epilepsy, threshold, development, neurological, pediatric, brain, temperature, convulsions, risk, factors, treatment, prevention, long-term, outcomes, neurology, health, conditions, medical, research, studies, evidence, association Febrile seizures, epilepsy, threshold, development, neurological disorders, pediatric neurology, brain disorders, seizure disorders, epilepsy risk factors, febrile convulsions, neurological complications, brain development, child health, medical research, clinical studies Febrile, seizures, epilepsy, threshold, development, neurological, conditions, pediatric, brain, disorders, fever, convulsions, risk, factors, medical, research, neurology, treatment, prevention Febrile seizures, epilepsy, threshold, development, neurological disorders, pediatric neurology, seizure disorders, brain disorders, clinical neurology, neurodevelopmental disorders febrile seizures, epilepsy threshold, development epilepsy, neurological disorders, pediatric neurology, seizure disorders, brain injury, fever-induced seizures, long-term effects seizures, epilepsy risk factors
411	Febrile seizures reduce the threshold for development of epilepsy. febrile, seizures, epilepsy, threshold, development, neurological, conditions, pediatric, brain, disorders, risk, factors, neurology, medical, research, treatment, prevention, health, impact, complications febrile, seizures, epilepsy, threshold, development, neurological, disorders, pediatric, brain, temperature, convulsions, risk, factors, medical, conditions, treatment, prevention febrile seizures, epilepsy, development threshold, neurological disorders, pediatric neurology, brain disorders, seizure disorders, temperature-related seizures, convulsions, neurodevelopmental risks febrile seizures, epilepsy, threshold reduction, neurological disorders, pediatric neurology, seizure disorders, brain development, long-term outcomes, epilepsy risk factors, febrile seizures complications febrile seizures, epilepsy, threshold reduction, neural excitability, pediatric neurology, seizure disorders, brain development, neurological outcomes, epilepsy risk factors, febrile status epilepticus
532	Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis. Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, decreases, vascular, surgery, hemostasis, fibrinogen, levels, leg, arterial, disease, patency, outcome, medical, treatment, prevention Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, blood clotting, vascular surgery, cardiovascular disease, hemostasis, fibrinogen levels, surgical outcomes, arterial surgery Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, decreases Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, decreased rates, vascular surgery, blood clotting disorders, fibrinogen levels, arterial surgery, thromboresistance, clinical outcomes hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, surgery, vascular, blood, clotting, prevention, treatment, medical, research, clinical, studies, outcomes, patients, risk, factors, arteries, leg, circulation, health, intervention, efficacy, complications, healing, recovery, time, mortality, morbidity
533	Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis. Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, vascular, surgery, hemostasis, blood, clotting, disorders, cardiovascular, risk, factors, surgical, complications Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, vascular, surgery, complications, hemostasis, fibrinogen, levels, blood, clotting, disorders, peripheral, artery, disease, intervention, outcomes Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, vascular, surgery, blood, clotting, disorders, hypercoagulability, arterial, veins, medical, treatment, prevention, complications, research, clinical, trials, hemostasis, fibrinogen, levels, cardiovascular, disease, risk, factors, patient, care, outcomes, health, intervention, studies, evidence, practice, guidelines, medication, therapy, intervention, management, prognosis, surgery, techniques, outcomes, assessment, tools, methods, diagnosis, imaging, tests, biomarkers, markers, blood, tests, Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, rates, vascular, surgery, hemostasis, fibrinogen, blood, clotting, disorders, peripheral, arterial, disease, cardiovascular, risk, factors, medical, complications, treatment, prevention Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, vascular surgery, blood clotting, fibrinogen levels, arterial disease, surgical outcomes, thrombotic complications
775	Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR). Mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR mice, DNA polymerase I, polI, defective, ionizing radiation, IR, sensitivity, increased, mutation, repair, genotoxic, stress, cellular response, radiation biology, molecular genetics Mice, DNA polymerase I, polI, defective, increased sensitivity, ionizing radiation, IR, genetic mutation, radiation response, DNA repair deficiency mice, defective, DNA, polymerase, I, polI, increased, sensitivity, ionizing, radiation, IR, genetic, mutation, DNA, repair, cellular, response, radiation, therapy, genetic, disorders, DNA, replication, enzyme, deficiency, irradiation, cancer, treatment, molecular, biology, genetics, radiobiology
1199	The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins. colchicine, benefits, secondary prevention, strategies, high-dose statins, cardiovascular, pharmacotherapy, clinical outcomes, risk reduction, treatment efficacy colchicine, benefits, secondary prevention, high-dose statins, effective use, cardiovascular disease, prevention strategies, widespread application colchicine, benefits, secondary prevention, strategies, high-dose statins, cardiovascular, health, pharmacology, medication, treatment, prevention methods, heart disease, lipid lowering, cholesterol management colchicine, benefits, secondary prevention, high-dose statins, cardiovascular, treatment, pharmacology, clinical outcomes, medicine, health strategies colchicine, benefits, secondary prevention, high-dose statins, cardiovascular, therapy, pharmacology, treatment, prevention strategies, clinical outcomes
535	Hypertension is frequently observed in type 1 diabetes patients. hypertension,type 1 diabetes,diabetes patients,high blood pressure,cardiovascular risk,frequent comorbidity,diabetic hypertension hypertension, type 1 diabetes, diabetes patients, observed, medical condition, chronic disease, cardiovascular risk, insulin-dependent diabetes, blood pressure, healthcare management Hypertension, Type 1 Diabetes, Patients, Frequent Observation, Comorbidity, Cardiovascular Risk, Blood Pressure, Diabetes Mellitus, Hypertensive Disorders, Clinical Prevalence hypertension, type 1 diabetes, prevalence, comorbidity, cardiovascular risk, diabetic patients, blood pressure, chronic conditions, endocrine disorders, clinical studies hypertension,type 1 diabetes,observed,frequency,patients,comorbidities,blood pressure,diabetes mellitus,image,NIDDM,hyperglycemia,cardiovascular risks
415	Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia. Female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia Female, carriers, Apolipoprotein, APOE4, allele, increased, risk, dementia Female, carriers, Apolipoprotein, APOE4, allele, increased, risk, dementia female, carriers, Apolipoprotein, APOE4, allele, increased, risk, dementia Female, Carriers, Apolipoprotein E4, APOE4, Allele, Increased Risk, Dementia
536	Hypocretin neurones induce panicprone state in rats. hypocretin, neurones, panic-prone, state, rats, induction, neuroscience, fear, anxiety, brain, research, animal, model, behavior, emotional, response, neural, circuit, activation, stress hypocretin neurones, panic-prone state, rats, anxiety, neural activity, neurotransmitter role, stress response, behavioral modification, experimental models, neurological disorders Hypocretin, neurones, panic-prone, state, rats, induction, neuroscience, behavioral, research, anxiety, panic, disorder, animal, model, brain, study, experiment, neurobiology, fear, response, stress, neural, pathways, hypothalamus, serotonin, neurotransmitters, pharmacology, mental, health, physiological, reactions, cortisol, hormones, amygdala, cortical, circuits, synaptic, transmission, cell, signaling, molecular, biology, genetics, preclinical, testing, psychological, impact, treatment, therapies, intervention, clinical, relevance, symptom, expression, modulation, influence, environmental hypocretin, neurones, panic-prone, state, rats, neurological, research, behavior, induction, anxiety, fear, physiology, neuroscience, animal, models, stress, response, brain, function, disorders Hypocretin, neurones, panic-prone, state, rats, induction, neuroscience, behavioral, research, anxiety, neurobiology, sleep, disorders, brain, chemistry, receptors, signaling, pathways, animal, studies, emotional, regulation, stress, response
659	Ivermectin is used to treat lymphatic filariasis. Ivermectin, lymphatic filariasis, treatment, antiparasitic, medication, filariasis therapy, tropical disease, parasitic infection, drug use, medical intervention Ivermectin, lymphatic filariasis, treatment, parasitic infection, antiparasitic, medication, disease, tropical medicine, public health, filariasis control Ivermectin, lymphatic filariasis, treatment, parasitic infection, antiparasitic, medication, disease management, elephantiasis, tropical medicine, public health intervention Ivermectin, lymphatic filariasis, treatment, medication, parasitic disease, elephantiasis, anti-parasitic, therapy, filariasis management, drug treatment Ivermectin, lymphatic filariasis, treatment, parasitic infection, filariasis medication, antiparasitic drug, elephantiasis prevention, river blindness drug, tropical disease treatment
539	Hypoglycemia increases the risk of dementia. Hypoglycemia, dementia, risk, association, cognitive impairment, neurological disorders, blood sugar, diabetes, elderly, brain health Hypoglycemia, dementia, risk, brain, glucose, elderly, cognitive, decline, diabetes, neurological, impact, health, studies, evidence, prevention, treatment Hypoglycemia, dementia, risk, association, impact, neurological, glucose, brain, cognitive, decline, insulin, treatment, diabetes, elderly, prevention, health, complications, study, research, evidence, mechanisms, link, factors, outcomes, prevalence hypoglycemia, dementia, risk, blood sugar, cognitive decline, neurological impact, diabetes, elderly, brain health, glucose levels, insulin, treatment, prevention, research, epidemiology, complications, health outcomes, medical conditions, neurological disorders hypoglycemia, dementia, risk, glucose, brain, cognition, elderly, diabetes, neurodegeneration, insulin,卒
1099	Statins decrease blood cholesterol. statins, blood, cholesterol, decrease, lipid, treatment, cardiovascular, health, medication, pharmacy Statins, blood cholesterol, lipid-lowering, cardiovascular health, HMG-CoA reductase inhibitors, cholesterol reduction, heart disease prevention statins, blood, cholesterol, reduce, medication, lipid, levels, cardiovascular, health, treatment, efficacy statins, cholesterol, blood, decrease, lipid, heart, health, medication, treatment, levels statins, cholesterol, blood, reduction, lipid, cardiovascular, treatment, health, medication, pharmacy, clinical, evidence, study, levels, effect, mechanism, side-effects, benefits, prevention, therapy
660	Ivermectin is used to treat onchocerciasis. Ivermectin, Onchocerciasis, Treatment, Anti-parasitic, Medication, River Blindness, Parasitic Infection, Drug Therapy Ivermectin, Onchocerciasis, Treatment, Parasitic, Disease, Medication, Antiparasitic, Health, Infection, Therapy Ivermectin, Onchocerciasis, Treatment, Drug, Parasitic, Disease, Medication, Therapy, Antiparasitic, Infection, Nematode, River, Blindness, Skin, Nodes, Microfilariae, Tropical, Medicine, Health, World, Health, Organization, Pharmacy, Veterinary, Human, Clinical, Trials, Effectiveness, Safety, Dosage, Administration, Side, Effects, Prevention, Control, Elimination, Public, Health, Intervention, Community, Tropical, Medicine, Global, Health, Infectious, Diseases, Parasitology, Pathology, Microbiology, Epidemi Ivermectin, Onchocerciasis, Treatment, Medication, Parasitic, Disease, River, Blindness, Antiparasitic, Therapy Ivermectin, Onchocerciasis, Treatment, Medication, Parasitic Disease, River Blindness, Antiparasitic, Therapeutic Use
781	Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis. Mice, Interferon-γ, Receptor, Resistance, Experimental, Autoimmune, Myocarditis, Immunology, Genetics, Cardiology, Animal, Model, Disease, Inflammation, Cytokine, Knockout, Mutation, Pathogenesis, Therapy Mice, Interferon-γ, receptor, resistance, experimental, autoimmune, myocarditis, immunology, inflammation, cardiology, genetics, knockout, animal, model, disease, susceptibility, cytokine, signaling, pathway Interferon-γ, receptor deficiency, mice, experimental autoimmune myocarditis, resistance, immunology, autoimmune diseases, cardiac inflammation, knockout mice, cytokine signaling Mice, Interferon-γ, receptor, resistance, experimental, autoimmune, myocarditis, knockout, immune response, cardiac inflammation Mice, Interferon-γ, receptor, resistance, experimental, autoimmune, myocarditis, knockout, immune response, cardiac inflammation, gene deficiency, animal model, immune-mediated heart disease
540	Hypothalamic glutamate neurotransmission is crucial to energy balance. hypothalamic, glutamate, neurotransmission, energy, balance, crucial, neural, signaling, metabolism, appetite, regulation, obesity, neuroscience, endocrinology Hypothalamus, Glutamate, Neurotransmission, Energy, Balance, Metabolism, Appetite, Regulation, Obesity, Neural, Signaling, Pathways, Homeostasis Hypothalamus, Glutamate, Neurotransmission, Energy, Balance, Metabolism, Feeding, Obesity, Neural, Circuits hypothalamic, glutamate, neurotransmission, energy, balance, crucial, brain, metabolism, neuropeptides, appetite, obesity, neural, circuits, signaling, regulation hypothalamic, glutamate, neurotransmission, energy, balance, crucial, neurobiology, metabolism, signaling, brain, obesity, appetite, regulation, neural, pathways, synapses, neurotransmitters, physiological, homeostasis
783	Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA. Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, autoimmune, myocarditis, cytokine, knockout, inflammation, immune response, cardiology, animal model Mice, IFN-γ, receptor, resistance, EAM, α-MyHC, CFA, immunity, autoimmunity, cardiology, inflammation, immunology, experimental, animal, model, disease, induction, cytokine, knockout, receptor-deficient Mice, IFN-γ, receptor, EAM, α-MyHC, CFA, resistance, immunology, autoimmune, myocarditis Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, immunology, autoimmunity, cardiology, inflammation, knockout, animal model Mice, IFN-γ, receptor, resistant, EAM, α-MyHC, CFA, immunology, autoimmune, myocarditis
300	Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake. cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, cellular iron regulation Cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, mRNA binding, iron metabolism, cellular iron regulation Cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, proteins, binding, iron metabolism, cellular iron regulation, mRNA binding proteins Cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, cellular iron regulation, mRNA binding proteins, iron metabolism, cellular transport proteins cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, proteins, binding, regulation, iron metabolism
421	Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules. flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, cancer therapy, drug delivery, tumor penetration, molecular structure, pharmacokinetics flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, cancer treatment, drug delivery, medicinal chemistry flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, tumor penetration, drug delivery, cancer treatment, molecular structure, therapeutic efficiency flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, tumor penetration, drug delivery, cancer therapy, molecular dynamics, bioavailability flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, tumor tissue, drug delivery, cancer treatment, molecular structure, therapeutic efficiency
784	MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, stem cell biology, neurogenesis MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, stem cell biology, miRNA, neurogenesis, cell cycle control, genes, signaling pathways, brain development, tissue homeostasis, molecular biology, neuroscience MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, neural development, stem cell biology MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, miRNA, stem cell biology, neurogenesis, molecular biology, cell proliferation, cell differentiation, RNA regulation, neural development MicroRNA, Neural Stem Cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, stem cell biology, miRNA, neurogenesis, cell cycle control, neural development
785	Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures. Microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, improvement, retrieval Microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, improvement, retrieval microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, improvement, retrieval microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, poor-correlation, bioinformatics, microbiology microarray, culture-amplified, serotypes, correlation, uncultured, mixtures, results, poor, comparison, genetic, expression, analysis, biological, samples, methodology, contamination, variability, interpretation, data, accuracy, reliability, research, study, science, technology, biology, molecular, diagnostics, laboratory, techniques, experimental, design, validation, performance, specificity, sensitivity, pathogens, detection, identification, typing, strains, species, environment, clinical, samples, public, health, surveillance, epidemiology, infectious, diseases, virology, bacteriology, mycology, parasitology, immunology
544	IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs. IFIT1, viral replication, sequestration, mis-capped RNAs, antiviral mechanism, immune response, RNA binding, viral infection, host defense, molecular biology IFIT1, viral replication, sequestration, mis-capped, viral RNAs, antiviral defense, immune response IFIT1, viral replication, sequestration, mis-capped, viral RNAs, antiviral, restriction, immune response IFIT1, viral replication, sequestrating, mis-capped, viral RNAs, antiviral, immune response, RNA binding, pathogen recognition, innate immunity IFIT1, viral replication, sequestration, mis-capped RNAs, antiviral mechanism, RNA binding, immune response
303	DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region. DMRT1, sex-determination, epigenetic-regulation, MHM-region, gene-expression, chromosomal-sex-determination, genetic-regulation, molecular-biology, developmental-biology, sex-chromosomes DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosome, gene expression, sexual development, genetic regulation, methylation, histone modification DMRT1, sex-determining, gene, epigenetic, regulation, MHM, region, chromosome, development, sexual, differentiation, methylated, histone, modification DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosomal sex determination, gene expression, molecular biology, genetics, developmental biology DMRT1, sex-determining gene, epigenetic regulation, MHM region, chromosomal sex determination, genetic regulation, epigenetics, gene expression, sex chromosome, development biology
1089	Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. Smc5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement, molecular biology, protein interaction, ATP-dependent process, SUMOylation, cell cycle regulation SMC5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement, molecular biology, protein interaction, enzymology SMC5/6, Mms21, SUMO, E3 ligase, ATP, remodeling, activation, engagement, protein complex, post-translational modification, molecular biology, cell cycle regulation, chromatin structure, DNA repair, genetic stability Smc5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement, protein complex, molecular mechanism, cellular process, gene regulation, chromosome stability Smc5/6, Mms21, SUMO, E3 ligase, ATP, remolding, activation, engagement
549	IRG1 has antiviral effects against neurotropic viruses. IRG1, antiviral, neurotropic, viruses, immune response, gene expression, virology, molecular biology, infection, neuroscience IRG1, antiviral, neurotropic, viruses, immune-response, infection, virology, neuroscience, immunology, molecular-biology IRG1, antiviral, neurotropic, viruses, immune, resistance, gene, infection, pathogen, treatment, prevention, molecular, mechanism, therapeutic, target IRG1, antiviral, neurotropic, viruses, immune, response, gene, infection, treatment, prevention, research, molecular, mechanism, pathways IRG1, antiviral, neurotropic, viruses, immunity, infection, neuroscience, viral, resistance, brain, central nervous system, pathogen, host defense, molecular biology, virology
551	ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, immunology, cell signaling, biochemistry ITAM, phosphorylation, TCR, T-cell receptor, signal transfer, echo-domain, cytoplasmic tail ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, prevention, signal transfer ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, immunology, cell signaling, molecular biology ITAM, phosphorylation, TCR, signal, echo-domain, cytoplasmic tail, T cell receptor, immune signaling, lymphocyte activation, molecular biology, immunology
793	Mitochondria are uninvolved in apoptosis. mitochondria, apoptosis, uninvolved, cell-death, biochemical-processes, organelle-functions mitochondria, apoptosis, uninvolved, cell death, mitochondrial function, apoptosis regulation, cellular processes, biochemistry, cell biology mitochondria, apoptosis, uninvolved, cell-death, mitochondrial-function, biochemistry, cellular-processes mitochondria, apoptosis, uninvolved, cell-death, mitochondrial-function, bioenergetics, caspase-activation, apoptosis-regulation, cellular-signaling, mitochondria-role mitochondria, apoptosis, uninvolved, cell-death, mitochondrial-function, biochemical-pathways, cellular-processes, apoptosis-mechanisms, mitochondria-role, scientific-research, biology, genetics, cell-biology, molecular-biology
431	FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS). FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, mediation, neurodegeneration, oxidative, stress FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, signaling, neurodegeneration, oxidative, stress, apoptosis, brain, cells, neuroprotection FoxO3a, activation, neuronal, death, reactive, oxygen, species, ROS, mediation, neurodegeneration, oxidative, stress, signaling, pathway FoxO3a, neuronal death, reactive oxygen species, ROS, activation, mediation, neurodegeneration, oxidative stress, cellular signaling, apoptosis FoxO3a, neuronal death, reactive oxygen species, ROS, activation, mediation, neurodegeneration, oxidative stress, cell signaling, apoptosis
552	IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet. IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, accumulation, celiac disease, diet initiation, immune response, intestinal lining, autoimmune response IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, autoimmune response, dietary intervention, intestinal immunity IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, accumulation, celiac disease, dietary intervention, immune response, gut inflammation IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, accumulation, celiac disease, dietary intervention, immune response, intestinal biopsy IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, immune response, intestinal immunity, dietary intervention, gluten sensitivity
674	LDL cholesterol has no involvement in the development of cardiovascular disease. LDL, cholesterol, cardiovascular, disease, involvement, development,血脂, 心血管疾病, 低密度脂蛋白 LDL, cholesterol, cardiovascular, disease, involvement, development, no, link, correlation, absence, role, impact, health, arteries, plaque, risk, factors, blood, fats, transport, body, medical, research, studies, evidence, contrary, support, debunk, myth, truth, science, biology, cardiovascular, system, lipids, atherosclerosis, prevention, treatment, management, heart, stroke, vascular, disorders, healthy, lifestyle, diet, exercise, medication, management, guidelines, recommendations,clinical, trials, epidemiology, public, health, awareness, education LDL, cholesterol, cardiovascular, disease, development, involvement, lipid, atherosclerosis, heart, health LDL cholesterol, cardiovascular disease, cholesterol role, heart disease, lipid hypothesis, atherosclerosis, blood lipids, cardiovascular risk, cholesterol impact, health claims, medical controversies LDL, cholesterol, cardiovascular, disease, involvement, development, health, blood, fats, arteries
312	De novo assembly of sequence data has more specific contigs than unassembled sequence data. de novo assembly, sequence data, specific contigs, unassembled data, genomics, bioinformatics, DNA sequencing, contig assembly, reference-free assembly, genome assembly techniques de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genome assembly, NGS, next-generation sequencing, contig specificity, assembly quality de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genomics, data assembly, nucleotide sequences, genetic information, genome reconstruction de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genome assembly, DNA sequencing, contig specificity, assembly methods, genetic data processing de novo assembly, sequence data, specific contigs, unassembled sequence, bioinformatics, genomics, DNA sequencing, contig assembly, genetic data processing, molecular biology techniques
554	Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1. Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, apoptosis, necrosis, signaling pathways Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, necrosis, apoptosis, neutrophils, HMGB1 release, immune-mediated cell death, extracellular HMGB1, protein release mechanism Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, neutrophils, apoptosis, necrosis, signaling pathways, cytokines, immune-mediated diseases Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, neutrophils, protein release, immune-mediated cell death Immune complex, cell death, extracellular release, neutrophil protein, HMGB1, inflammation, immune response, apoptosis, necrosis, neutrophils
314	Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome. deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, mutation, enzymatic conversion, nucleotide alteration deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome Deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, mutation, DNA modification, virology deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome
436	Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated. free histones, Rad53-dependent mechanism, DNA replication, histone degradation, cell cycle regulation, chromatin dynamics, DNA repair, molecular biology, genetics, biochemistry Rad53, DNA replication, histone degradation, free histones, cell cycle, protein degradation, checkpoint kinase, yeast genetics, molecular biology, protein kinases Free histones, Rad53-dependent, degradation, DNA replication, cell cycle, protein degradation, histone turnover, post-replicative, checkpoint mechanisms Free histones, Rad53-dependent, degradation, DNA replication, post-replication, protein degradation, cell cycle, histone turnover histones, Rad53, degradation, DNA replication, free histones, cell cycle, chromatin remodeling, protein degradation, replication-dependent, checkpoint kinase
437	Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model. Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research gaps, hematopoietic disorders, genetic mutations, disease mechanisms, preclinical studies, MDS pathogenesis Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research limitations, hematopoietic disorders, genetic mutations, bone marrow failure, cancer genetics, preclinical studies Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, research gaps, MDS pathogenesis, molecular mechanisms, genetic mutations, disease modeling, hematopoietic stem cells, clinical translation, therapeutic targets Myelodysplastic syndrome, genomic alterations, functional consequences, animal model, MDS, research challenges, genetic disorders, hematological diseases, molecular biology, cancer genetics Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, research limitations, hematological disorders, genetic mutations, molecular biology, oncology
439	Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation, development, cell polarity, signaling pathway, embryo, morphogenesis, tissue organization, protein localization Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation Fz, PCP-dependent, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation, localization, development, embryology, cell biology, molecular biology, signaling pathways, polarity proteins, model organisms Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation, planar cell polarity, developmental biology, embryogenesis Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neuralation
560	Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs. immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, T-cell differentiation, cytokine signaling, immune regulation, inflammation, immunology, adaptive immunity, regulatory T cells Immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, development, immune system, T cells, inflammation, regulatory T cells, immune regulation immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, Th17, iTregs, immune system, inflammation, regulatory T cells, adaptive immunity, cytokines, immune regulation, cell differentiation, immune cell types, autoimmune diseases, immunology Immune responses, inflammatory, Th17 cells, anti-inflammatory, iTregs, cell development, immune regulation, T cell differentiation, cytokines, inflammation, autoimmunity, immune tolerance immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, T cell differentiation, immune regulation, cytokine production, immune-mediated diseases, autoimmunity, immunology, cellular immunity, adaptive immunity, regulatory T cells, inflammation, Th17 cells, iTregs, immune system, T helper cells, tolerance, homeostasis, interleukins, lymphocytes, immune signaling, gene expression, cell-mediated immunity, autoinflammatory disorders, immunotherapy
440	Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation. Fz, PCP, Pk, anterior, membrane, notochord, cells, zebrafish, neurulation Fz, PCP, Pk, anterior, membrane, notochord, cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation Fz, PCP, Pk, anterior, membrane, notochord, cells, zebrafish, neuralation
1303	Tirasemtiv has no effect on fast-twitch muscle. Tirasemtiv, fast-twitch muscle, no effect, muscle response, clinical trials, pharmacology, muscle contraction, strength, treatment outcomes, muscle fiber types Tirasemtiv, fast-twitch muscle, no effect, muscle response, pharmacology, clinical trials, muscle fibers, drug efficacy, skeletal muscle, treatment outcomes Tirasemtiv, fast-twitch muscle, effect, muscle function, pharmacology, muscle response, clinical trial, no effect, muscle contraction, treatment outcome Tirasemtiv, fast-twitch muscle, no effect, muscle function, pharmacology, muscle contraction, drug efficacy, clinical trial, muscle response, treatment outcome Tirasemtiv, fast-twitch muscle, muscle effect, no effect, pharmacology, muscle function, clinical trials, muscle fibers, drug response, skeletal muscle
684	Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells. Bacillus subtilis, sporulation efficiency, clpC, gene deletion, bacterial genetics, molecular biology, microbiology, spore formation, regulatory proteins, stress response clpC, sporulation, Bacillus subtilis, efficiency, genetic knockouts, bacterial physiology, molecular genetics, sporulation defects, proteolysis, regulatory mechanisms Bacillus subtilis, sporulation, clpC, gene knockout, bacterial genetics, molecular biology, microbiology, gene function, spore formation, bacterial spores, protein ClpC, regulatory mechanisms, microbial physiology, cellular processes Bacillus subtilis, clpC, sporulation efficiency, genetic mutation, bacterial genetics, molecular biology, microbiology, cell biology, gene function, protein function, sporulation process, bacterial spores, clpC gene, gene knockout, bacterial growth, microbial genetics, gene expression, bacterial physiology, microbial research clpC, sporulation, Bacillus subtilis, gene knockout, bacterial genetics, spore formation, molecular biology, microbiology, bacterial physiology, genetic regulation
443	GATA-3 is important for hematopoietic stem cell (HSC) function. GATA-3, hematopoietic stem cells, HSC function, transcription factor, blood cell development, immune system, stem cell regulation, hematopoiesis, gene expression, cellular differentiation GATA-3, hematopoietic, stem, cell, function, HSC, transcription, factor, development, differentiation, blood, lineage, regulation, expression, signaling, immune, system, progenitor, cells, genetics, molecular, biology, hematopoiesis, research, medical, science, oncology, therapy, biomarker, disease, treatment, drug, target, pathway, interaction, genetics, epigenetics, chromatin, modification, enhancer, promoter, binding, site, assay, experiment, model, mouse, human, clinical, trial, study, publication, review, article, journal, database GATA-3, hematopoietic, stem, cell, function, HSC, transcription, factor, development, differentiation, blood, formation, lineage, commitment, regulation, gene, expression, signaling, pathway, immune, system, progenitor, cells, cytokines, growth, factors, survival, proliferation, apoptosis, self-renewal, niches, microenvironment, transplantation, diseases, therapy, research, models, molecular, biology, genetics, immunology, oncology, genetics, epigenetics, chromatin, remodeling, enhancers, promoters, binding, sites, inhibitors, activators, modifiers, specificity GATA-3, hematopoietic stem cell, HSC function, transcription factor, blood cell development, immune system, stem cell regulation, cellular differentiation, gene expression, hematopoiesis GATA-3, hematopoietic stem cell, HSC function, transcription factor, blood cell development, stem cell maintenance, hematopoiesis regulation, immune system, lymphoid differentiation
324	Deleting Raptor reduces G-CSF levels. Deleting,Raptor,reduces,G-CSF,levels,cytokine,protein,signal,transduction,pathway,immunology,hematopoiesis Deleting,Raptor,G-CSF,levels,reduces Deleting,Raptor,reduces,G-CSF,levels Deleting,Raptor,G-CSF,levels,reduces Deleting,Raptor,reduces,G-CSF,levels,Granulocyte-colony Stimulating Factor,Raptor protein,knockout,mice,blood cells,proliferation,cell signaling,pathway,genetic modification,biomarker,hematopoiesis
327	Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype. αvβ8, deletion, inflammatory, phenotype, spontaneous, integrin, immune response, knockout, mice, inflammation, genetics, cell signaling, biological processes αvβ8, deletion, inflammatory phenotype, spontaneous, absence, immune response, genetic modification, integrin, cell signaling, immune system, biological processes, molecular biology, research, science αvβ8, deletion, spontaneous, inflammatory, phenotype, integrin, knockout, mice, immune response, tissue homeostasis αvβ8, deletion, inflammatory, phenotype, spontaneous, integrin, immunity, mouse, knockout, inflammation, absence, disease, health, molecular, biology, genetics, research, study, scientific, medical, cellular, response αvβ8, deletion, inflammatory phenotype, spontaneous, integrin, immunology, cell adhesion, protein function, biological process, research study
569	In adult tissue, most T cells are memory T cells. adult tissue, T cells, memory T cells, immune system, lymphocytes, adaptive immunity, cellular immunity, immunology, human body, immune response adult tissue, T cells, memory T cells, immune system, lymphocytes, cellular immunity, adaptive immunity, immunology, white blood cells, antigen-specific response adult tissue, T cells, memory T cells, immune system, adaptive immunity, lymphocytes, cellular immunity, immune response, antigen-specific, long-lived, circulating lymphocytes, secondary immune response adult tissue, T cells, memory T cells, immune system, lymphocytes, cellular immunity, adaptive immunity adult tissue, memory T cells, T cells, immune response, lymphocytes, adaptive immunity, cellular immunity, immunology, tissue-resident memory T cells, circulating memory T cells
208	CHEK2 is not associated with breast cancer. CHEK2, breast cancer, genetic association, oncology, mutation, risk factor, clinical research, biomarker, cancer genetics, tumor suppressor gene CHEK2, breast cancer, genetic association, oncology, cancer genetics, mutation, tumor suppressor gene, clinical genetics, molecular biology, cancer predisposition CHEK2, breast cancer, genetic association, negative correlation, oncology, tumor suppressor gene, cancer research, genetic studies, molecular biology CHEK2, breast cancer, genetic association, negative correlation, oncology, cancer genetics, mutation analysis, clinical significance, genetic testing, epidemiology CHEK2, breast cancer, negative association, genetic studies, oncology, cancer genetics, molecular biology, gene mutation, risk assessment, clinical research
690	Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. SFM, Schimmelpenning-Feuerstein-Mims, Gabonese, children, plasma, lactate, 5mmol/L, less, 10% gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, rare disease, metabolic disorder, pediatric case study, biochemical marker, lactate levels Schimmelpenning-Feuerstein-Mims syndrome, SFM, Gabonese children, plasma lactate, 5mmol/L, medical condition, metabolic disorder, rare disease, pediatric health, biochemical markers gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic disorder, rare disease,非洲儿童, 代谢异常, 罕见病 gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic disorder, genetic condition, clinical study, rare disease, pediatric research
691	Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation. Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, protein regulation, cancer research, cellular signaling, molecular biology Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, repression, cellular signaling, cancer biology, molecular biology, protein interaction, oncology Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, repression, signaling pathway, cancer research, molecular biology, cell biology, protein interaction, guanine nucleotide exchange factors, oncology, leukemia treatment, cellular signaling, protein regulation, cancer signaling, Rho GTPases, SRC family kinases, leukemia pathogenesis, gene expression regulation Leukemia, Rho, guanine, nucleotide-exchange, factor, RhoA, repression, SRC, activation, signaling, oncogene, hematopoietic, cells, protein, interaction, cancer, biology, molecular, pathway Leukemia, Rho, guanine, nucleotide-exchange, factor, represses, RhoA, response, SRC, activation
692	Leuko-increased blood increases infectious complications in red blood cell transfusion. leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, inflammation, immune, response, donor, recipient, hematology, transfusion, medicine, clinical, outcomes, patient, safety, medical, research, transfusion-related, infections, white, cells, hematopoietic, disorders, blood, banking, transfusion, therapy, immunology, medical, treatment, transfusion-associated, morbidity leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, inflammation, immune, response, transfusion-related, infections, hematologic, disorders, medical, treatment, patient, care, clinical, research, hematology, transfusion, medicine, cellular, immunology, pathology, therapeutic, strategies, blood, banking, transfusion, safety, healthcare, protocols, patient, outcomes, medical, complications, transfusion, reactions leuko-increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, inflammation, immune, response, transfusion-related, infection, risk, hematologic, disorders, clinical, outcomes leukocytes, increased, blood, infectious, complications, red, blood, cell, transfusion, immune, response, pathogens, contamination, transfusion-related, infection, leuko-reduced, transfusion, therapy, hematology, medical, research Leuko, increased, blood, infectious, complications, red, blood, cell, transfusion, leukocytes, infection, hematology, transfusion, medicine, patient, care, immune, response, healthcare, treatment, clinical, outcomes
1316	Transferred UCB T cells acquire a memory-like phenotype in recipients. UCB, T cells, memory-like phenotype, recipients, cell transfer, immunology, adaptive immunity, cellular memory, transplantation, adoptive cell therapy UCB T cells, memory-like phenotype, recipients, cell transfer, immune response, transplantation, adoptive cell therapy, T cell differentiation, long-term immunity, hematopoietic stem cell transplantation Transferred, UCB, T cells, memory-like, phenotype, recipients, immune response, cell therapy, adoptive transfer, immunology Transferred, UCB, T cells, memory-like, phenotype, recipients, immune response, cellular therapy, adoptive transfer, hematopoietic stem cells, cytokine expression, long-term survival, immunotherapy, cancer treatment, virus infection, immune modulation, clinical trials, T cell differentiation, biological markers, flow cytometry, gene expression analysis UCB T cells, memory-like phenotype, recipients, cell transfer, immune response, T cell differentiation, adoptive cell therapy
693	Leuko-reduced blood reduces infectious complications in red blood cell transfusion. leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, transfusions, leukocytes, filtered, transfusion-related, infections, reduction, hematological, transfusion-medicine, clinical, hematology, therapeutic, platelets, plasma, immune, response, medical, treatment, patient, care, safety, efficacy, studies, research, healthcare, transfusion, practice, guidelines, evidence-based, medicine, protocols, blood, banking, transfusion, services, immunology, pathophysiology, adverse, effects, prevention, strategies, donor, selection, processing, storage, quality, control, leuko-reduced,blood,infectious,complications,red,blood,cell,transfusion,leukocyte-reduction,transfusion-related,infections,hematology,clinical,outcomes,blood,bank,practice leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, immunological, reactions, filtration, storage, quality, clinical, outcomes, hematology, transfusion, medicine, patient, safety leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, reduces, risk, contamination, safer, transfusions, clinical, outcomes, patient, safety, hematological, treatments leuko-reduced, blood, infectious, complications, red, blood, cell, transfusion, reduces, risk, contamination, platelet, plasma, donor, recipient, immune, response, clinical, outcomes, hematology, transfusion, medicine
452	Gene expression does not vary appreciably across genetically identical cells. gene expression, genetically identical cells, cellular variability, molecular biology, genetic regulation, cell-to-cell variation, transcriptomics, gene regulation, identical DNA, genetic consistency gene expression, genetically identical cells, cell-to-cell variability, transcriptional noise, molecular biology, gene regulation, single-cell analysis, epigenetics, cellular heterogeneity, RNA sequencing gene expression, genetically identical cells, cellular variability, transcriptome stability, molecular biology, cell biology, genetics, gene regulation, single-cell analysis, RNA sequencing gene expression, genetic identity, cellular variation, identical cells, expression consistency, genetic uniformity, cellular expression, genetic cells, expression stability, genetic expression gene expression, genetic identical cells, variability, cellular genomics, transcriptomics, molecular biology, cell-to-cell variation, genetic determinism, biological consistency
212	CR is associated with higher methylation age. CR, methylation, age, epigenetic, biomarker, aging, health, longevity, dietary, restriction, DNA, modification, biological, clock, study, research, association, higher, level, increase CR, higher, methylation, age, epigenetic, aging, biological, calorie, restriction, DNA, methylation, biomarkers, longevity, healthspan CR, higher, methylation, age, epigenetic, longevity, dietary, restriction, aging, biomarkers CR, methylation, age, epigenetic, biomarker, aging, restriction, dietary, intervention, health, longevity CR, higher, methylation, age, association, epigenetic, biomarker, health, longevity, cellular, aging, DNA, modification
575	In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon. Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, uncommon, yeast, genetic variation, chromosome abnormalities Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, genetic variation, yeast genetics, chromosome abnormalities, aneuploidy frequency, yeast evolution Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, genetic variation, yeast genetics, aneuploidy frequency, chromosome stability Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, rarity, yeast genetics, chromosome abnormalities, aneuploidy frequency, yeast genomics Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, uncommon, yeast genetics, chromosome instability, aneuploidy frequency
213	CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. CRP, postoperative mortality, Coronary Artery Bypass Graft, CABG surgery, predictive value, cardiovascular surgery, inflammation markers, surgical outcomes CRP, postoperative mortality, CABG surgery, coronary artery bypass graft,预测,手术后死亡率,炎症标志物,心脏手术并发症,临床结果评估,医疗文献检索优化 CRP, postoperative, mortality, CABG, coronary artery bypass graft, predictive, surgery, cardiac, inflammation, biomarker CRP, postoperative, mortality, Coronary Artery Bypass Graft, CABG, surgery, predictive, inflammation, cardiac surgery, outcome, risk factors CRP, postoperative, mortality, CABG, surgery, predictive, cardiovascular, inflammation, biomarker, clinical-outcomes
577	In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers. mice, P. chabaudi, parasites, proliferation, early infection, inoculation, low numbers, high numbers mice, P. chabaudi, parasites, proliferation, infection, inoculation, low numbers, high numbers, early infection, parasitology, malaria, host-parasite interaction mice, P. chabaudi, parasites, proliferation, infection, inoculation, low numbers, high numbers, early stage P. chabaudi, mice, infection, proliferation, parasites, inoculation, low numbers, high numbers, early infection, malaria, red blood cells, immune response, disease progression, parasitology, host-pathogen interaction P. chabaudi, mice, infection, parasites, proliferation, inoculation, low numbers, high numbers, early infection
578	In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis. mouse models, CSF1R loss, MOZ-TIF2, leuekmogenesis, oncogenesis, hematopoietic disorders, molecular biology, cancer research, cell signaling, leukemia models, genetic knockouts, receptor tyrosine kinases, transcriptional regulators, oncogenic fusion proteins mouse models, CSF1R loss, MOZ-TIF2, leukekmogenesis, facilitation, oncogenesis, hematopoietic system, leukemia development, signaling pathways, gene expression, cancer models, molecular biology, cell signaling, proto-oncogenes, receptor tyrosine kinases mouse models, CSF1R, loss, MOZ-TIF2, leukekmogenesis, facilitation, oncogenesis, hematopoiesis, leukemia, molecular biology, cancer research mouse models, CSF1R loss, MOZ-TIF2, leuekmogenesis, oncogenesis, hematopoietic system, cancer research, molecular biology, cell signaling, leukemia induction mouse models, CSF1R loss, MOZ-TIF2, leukekmogenesis, CSF1R deficiency, MOZ-TIF2 oncogene, hematopoietic system, leukemia development, genetic models, cancer biology, molecular mechanisms
216	CX3CR1 on the Th2 cells impairs T cell survival CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, lymphocyte apoptosis, cellular immunity, cytokine signaling, Th2 cytokines, immune cell interaction CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, cell death, lymphocyte activation, Th2 cytokines, chemokine receptor, inflammation CX3CR1, Th2 cells, T cell survival, impairment, immune response, lymphocytes, cytokines, chemokine receptor, cellular signaling, apoptosis, inflammation, immune regulation CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, cell migration, apoptosis, lymphocyte activation, inflammatory diseases, autoimmune disorders CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte apoptosis, cell-mediated immunity, inflammatory diseases, immune regulation, T helper cells
217	CX3CR1 on the Th2 cells promotes T cell survival CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte activation, cell migration, inflammatory diseases, molecular biology, immunology, cell signaling pathways CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, cellular signaling, lymphocytes, cytokine production, apoptosis regulation, immune cell interaction CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte activation, cellular immunity, chemokine receptors, Th2 differentiation, immune regulation CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, cell signaling, lymphocytes, Th2 differentiation, cytokine environment, immune regulation CX3CR1, Th2 cells, T cell survival, immune response, cytokine signaling, lymphocyte activation, cell signaling pathways, immunology, molecular biology, flow cytometry, gene expression, protein-protein interactions, inflammation, autoimmunity, cell death, apoptosis, cell proliferation, immune regulation, cytokines,chemokine receptor, Th2 cytokines, immune cells, hematopoietic cells, tissue microenvironment, signaling molecules, cellular immunity, adaptive immunity, immune system, physiological processes, research methods, scientific research, medical research, biology, T lymphocytes, immune modulation, cell survival mechanisms, experimental models
338	Dexamethasone decreases risk of postoperative bleeding. Dexamethasone, postoperative bleeding, risk reduction, surgery, hemostasis, medical treatment, pharmaceutical intervention, clinical outcomes Dexamethasone, postoperative bleeding, risk reduction, surgery, hemostasis, pharmacotherapy, clinical outcomes, anesthesia, surgical complications, bleeding disorders Dexamethasone, postoperative bleeding, risk reduction, surgical complications, hemostasis, drug efficacy, prevention, clinical outcomes Dexamethasone, postoperative bleeding, risk reduction, surgical complications, hemostasis, pharmacotherapy, clinical outcomes, anesthesiology, surgery, medication efficacy Dexamethasone, postoperative bleeding, risk reduction, surgical complications, hemostasis, medication efficacy, clinical outcomes, surgery, pharmacology, treatment effectiveness
218	CX3CR1 on the Th2 cells promotes airway inflammation. CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, inflammation promotion, Th2 cytokines, cellular signaling CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokines, cell signaling, inflammation promotion CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory diseases, asthma, cytokines, inflammation mediators, cell signaling CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, asthma, respiratory diseases, cellular signaling, inflammation mediators, lung immunology CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, respiratory disease, asthma, cytokine signaling, inflammation promotion, cell migration
219	CX3CR1 on the Th2 cells suppresses airway inflammation. CX3CR1, Th2 cells, airway inflammation, suppression, immune response, cytokines, asthma, lung, respiratory diseases, T-helper cells CX3CR1, Th2 cells, airway inflammation, suppression, immune response, cytokines, asthma, respiratory diseases, inflammation regulation, cellular signaling CX3CR1, Th2 cells, airway inflammation, suppression, immune response, cytokines, chemokine receptor, allergic asthma, respiratory diseases, immune modulation CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, asthma, cytokines, chemokine receptors, T-helper cells CX3CR1, Th2 cells, airway inflammation, suppression, immune response, respiratory diseases, cytokine signaling, inflammation regulation, asthma, allergic reactions
1319	Transplanted human glial cells can differentiate within the host animal. transplanted, human, glial, cells, differentiate, host, animal, neuroscience, cell, biology, transplantation, glia, differentiation, research, medical, science human glial cells, differentiation, host animal, transplanted cells, neural transplantation, glial cell research, animal model, cellular differentiation, neuroscience, brain research transplanted, human, glial, cells, differentiate, host, animal, neuroscience, brain, research, cell, biology, transplantation, glia, neural, tissue, integration, survival, function Transplanted, human, glial, cells, differentiate, host, animal, neuroscience, research, cell, biology, transplantation, glia, brain, spinal, cord, injury, regeneration, medicine, therapy Transplanted,human,glial,cells,differentiate,host,animal,tissue,brain,research,stem,neuroscience
100	All hematopoietic stem cells segregate their chromosomes randomly. hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, hematopoietic system, cell biology, genetics, mitosis, meiosis, chromosome distribution hematopoietic stem cells, chromosome segregation, random distribution, cell division, genetic material partitioning hematopoietic stem cells, chromosome segregation, random distribution, stem cell division, genetic material partitioning hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, genetic material distribution, hematopoietic cell cycle, chromosome behavior, cell biology, stem cell research, hematopoiesis hematopoietic stem cells, chromosomes, random segregation, cell division, genetics, stem cell biology, meiosis, mitosis, chromosome distribution, hematopoiesis
1204	The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells. H3K4me3, H3K79me2, quiescent, hair follicle stem cells, combination, epigenetic markers, stem cell biology, hair follicle, epigenetics, cellular quiescence H3K4me3, H3K79me2, quiescent, hair follicle stem cells, epigenetic marks, stem cell biology, chromatin modification, histone modification, quiescence, hair follicle, stem cells H3K4me3, H3K79me2, quiescent, hair follicle stem cells, combination, epigenetic marks, stem cell markers, cellular quiescence, hair follicle biology, chromatin modifications H3K4me3, H3K79me2, quiescent, hair follicle stem cells, epigenetic marks, chromatin modifications, stem cell regulation, quiescence maintenance, histone methylation H3K4me3, H3K79me2, quiescent, hair follicle stem cells, epigenetic marks, chromatin modification, stem cell biology, quiescence, hair follicle, stem cells, epigenetics, histone modification
343	Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. Diabetic, patients, acute, coronary, syndrome, increased, short-term, long-term, risk, bleeding, events Diabetic, patients, acute, coronary, syndrome, increased, short-term, long-term, risk, bleeding, events Diabetic patients, acute coronary syndrome, short-term risk, long-term risk, bleeding events, cardiovascular complications, diabetes management, ACS treatment, hemorrhagic complications, patient outcomes Diabetic, patients, acute, coronary, syndrome, increased, short-term, long-term, risk, bleeding, events Diabetic patients, acute coronary syndrome, increased risk, short-term risk, long-term risk, bleeding events, cardiovascular complications, diabetes management, coronary artery disease, thrombosis, anticoagulation therapy, hemostasis, clinical outcomes, patient care, medical treatment, risk factors, health complications
1202	The center of the granuloma in an immune cell induces a pro-inflammatory immune response. granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, pathology, immunology, cellular response, cytokines, macrophages, T-cells, lymphocytes, infection, disease, tissue reaction, microenvironment, signaling pathways granuloma, immune cell, pro-inflammatory, immune response, center, retrieval improvement, query enhancement granuloma, immune cell, pro-inflammatory, immune response, center, inflammation, cellular response, immunity, microenvironment, tissue reaction granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, cellular response, immune mechanism, pathology, medical term, biological process, immunology, disease mechanism, host defense, tissue reaction granuloma, immune cell, pro-inflammatory, immune response, center, induction
587	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers. transgenic mice, green florescent protein, Sox2 promoter, cell colocalization, cell proliferation markers, fluorescence microscopy, gene expression, neural stem cells, regulators of cell proliferation, GFP expression, transgene integration, embryonic development, tissue specificity, promoter activity, cellular markers, immunohistochemistry, quantitative analysis, cell biology, molecular biology transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell colocalization, cell proliferation markers, fluorescence microscopy, neurogenesis, stem cells, developmental biology, gene expression, protein localization, cellular biology, molecular biology, biotechnology, research methods, genetic engineering, fluorescence colocalization, marker expression, cellular markers, protein markers, biological research, gene regulation, promoter activity, transgenic models, cell biology, fluorescence imaging, biological assays, genetic markers, protein expression, cellular proliferation, cell cycle, fluorescence analysis, genetic constructs, biological experiments, fluorescence labeling, cell signaling, molecular markers, scientific research, genetic studies, transgenic mice, green florescent protein, Sox2 promoter, cell proliferation markers, colocalization, less than ten percent transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, fluorescence microscopy, developmental biology, stem cells, neurogenesis, gene expression analysis transgenic mice, green fluorescent protein, Sox2 promoter, cell colocalization, cell proliferation markers, GFP expression, Sox2-positive cells, fluorescence microscopy, cell biology, developmental biology, genetic engineering, mouse models, cellular proliferation, gene expression analysis
1200	The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1. ML-SA1, activator, binding orientation, hTRPML2, hTRPML1, difference, retrieval, query improvement binding, orientation, ML-SA1, activator, hTRPML2, hTRPML1, difference, interaction, protein, activation, membrane, ion, channel, residue, structure, complex, comparison, cellular, function, modulation ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval, improvement, query, optimization, protein, interaction, molecular, mechanism, specificity, pharmacology, biochemistry, cellular, signaling, modulation, drug, development, research, study, comparison, analysis, channel, regulation, structure, function, dynamics, affinity, efficacy, type, family, subunit, membrane, receptor, activation, inhibition, target, therapeutic, potential, application, profile, effect, impact, influence, role, pathway, process, response, system, network, cellular, signaling, ML-SA1, activator, binding orientation, hTRPML2, hTRPML1, difference, retrieval improvement ML-SA1, activator, binding, orientation, hTRPML2, hTRPML1, difference, retrieval, improvement, keyword, optimization, search, specificity, molecular, interaction, channel, protein, modulation
589	In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events. ADHD medications, young adults, middle-aged adults, cardiovascular events, risk, current use, remote use, safety ADHD medications, cardiovascular events, young adults, middle-aged adults, risk assessment, pharmacological treatment, neurodevelopmental disorders, long-term effects, heart health, clinical outcomes ADHD medications, young adults, middle-aged adults, cardiovascular events, risk, current use, remote use, serious health outcomes, pharmacological treatment, cardiological safety ADHD medications, young adults, middle-aged adults, cardiovascular events, risk, current use, remote use, safety, heart health, pharmacology, clinical trials, medical research, health outcomes, adverse effects ADHD medications, cardiovascular events, young adults, middle-aged adults, risk, current use, remote use, safety, health outcomes, pharmaceuticals, cardiology, neuropsychiatry
1320	Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons. transplanted,human,glial,progenitor,cells,incapable,forming,neural,network,host,animals,neurons transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons transplanted,human,glial,progenitor,cells,neural,network,host,animals,neurons,capability,formation,integration human glial progenitor cells, neural network formation, host animal neurons, cell transplantation, neurobiology, neuroscience, cellular interaction, brain research, glial cells, neuron communication transplanted, human, glial, progenitor, cells, incapable, forming, neural, network, host, animals, neurons
903	PD-1 triggering on monocytes reduces IL-10 production by monocytes. PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation, T-cell exhaustion, monocytic activation PD-1, monocytes, IL-10, production, reduction, triggering, immunology, cytokines, immune response, cell signaling PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation, cellular signaling, inflammation modulation PD-1, monocytes, IL-10, production, triggering, reduction, immune response, cytokine regulation, cell signaling, monocytic cells, immunology, inflammation, therapeutic targets PD-1, monocytes, IL-10, production, reduction, triggering, immune response, cytokine regulation
904	PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells. PDPN, C-type lectin receptor, actin cytoskeleton, dendritic cells, motility, stromal surfaces, activation, rearrangement PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, activation, rearrangement, cell migration, immune response PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, activation, rearrangement, cell migration, immune response, lymphocyte trafficking, cancer metastasis, inflammation PDPN, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, motility, activation, rearrangement PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, immune response, cytoskeletal rearrangement, cell surface interaction
1207	The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation. myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, protein composition, cell differentiation, isoform expression, myosin isoforms, hematopoiesis myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, protein composition, cell development, isoform expression, myosin isoforms, hematopoiesis myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, cell development, protein expression, myosin isoforms, hematopoiesis myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, composition change, cell differentiation, myosin isoforms, hematopoiesis, protein expression changes myosin-II, isoform, B isoform, A isoform, hematopoietic differentiation, composition switch, cell polarization, protein expression changes, blood cell development