907	PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. PGE2, prostaglandin E2, intestinal tumor, tumor growth, gene expression, tumor suppressor genes, DNA repair, carcinogenesis, inflammation, colon cancer, gene regulation, tumor biology PGE2, prostaglandin E2, intestinal tumor, tumor growth, gene expression, tumor suppressor genes, DNA repair, colorectal cancer, inflammation, carcinogenesis, cellular proliferation, genetic regulation PGE2, prostaglandin E2, intestinal tumor, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, cancer, colorectal cancer, tumor progression, inflammation, molecular pathways, gene regulation, oncogenesis PGE2, intestinal tumor growth, tumor suppressor genes, DNA repair genes, gene expression, cancer pathways, prostaglandin E2, tumorigenesis, colon cancer, inflammation, cell proliferation, oncogenes, molecular mechanisms PGE2, prostaglandin E2, intestinal tumor, tumor growth, gene expression, tumor suppressor genes, DNA repair genes, carcinogenesis, inflammation, colon cancer, gastrointestinal, cell proliferation, oncogenesis, molecular pathways
350	Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3. discrimination, initiator tRNAs, elongation tRNAs, translation initiation, factor IF3, translation, tRNA recognition, molecular biology, protein synthesis, ribosome, initiation factors discrimination, initiator tRNA, elongation tRNA, translation initiation factor, IF3, ribosomal selection, tRNA specificity, translation initiation, protein synthesis, ribosome, molecular biology discrimination, initiator tRNA, elongation tRNA, translation initiation factor, IF3, translation, tRNA recognition, ribosome, initiation complex, molecular biology discrimination, initiator tRNA, elongation tRNA, translation initiation factor, IF3, translation, tRNA selection, ribosome, ribosomal initiation, protein synthesis, molecular biology discrimination, initiator tRNA, elongation tRNA, translation initiation, IF3, translation factors, tRNA recognition, ribosome, translation accuracy, molecular mechanism
230	Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries. alcohol, aldehyde dehydrogenase, deficiency, mutation, carriers, alcohol metabolism, alcohol consumption, genetic variation, alcohol intolerance, enzyme deficiency, ADH, alcohol-related disorders alcohol aldehyde dehydrogenase, deficiency, mutation, carriers, consumption, alcohol intake, non-carriers, alcohol metabolism, genetic variation, alcohol intolerance alcohol, aldehyde dehydrogenase, deficiency, mutation, carriers, drinking behavior, alcohol metabolism, genetics, alcohol flush reaction, alcohol tolerance alcohol aldehyde dehydrogenase, deficiency, mutation, carriers, drinking behavior, alcohol metabolism, alcohol intolerance, genetic variation, alcohol consumption, enzymatic activity alcohol aldehyde dehydrogenase, deficiency, mutation, carriers, alcohol consumption, drinking behavior, genetic variation, alcohol metabolism, alcohol intolerance, alcohol-related genetics
593	Incidence of heart failure decreased by 10% in women since 1979. heart failure, incidence, decrease, women, 1979, percentage change, cardiovascular health, epidemiology, temporal trend, gender differences heart failure, incidence, women, decrease, 10%, 1979, epidemiology, cardiovascular disease, gender differences, temporal trend heart failure, incidence, decrease, women, 1979, mortality, epidemiology, cardiovascular disease, gender differences, trend analysis heart failure, incidence, decrease, women, 1979, epidemiology, cardiovascular health, gender differences, longitudinal study, public health heart failure, incidence, women, decrease, 10%, 1979, trend, epidemiology, cardiovascular health, gender differences
1216	The extracellular domain of TMEM27 is cleaved in human beta cells. extracellular domain, TMEM27, cleavage, human beta cells, transmembrane proteins, protein processing, beta cell biology, membrane proteins, proteolytic cleavage, cell signaling extracellular domain, TMEM27, cleavage, human beta cells, proteolysis, insulin secretion, beta cell function, transmembrane protein, cell surface, membrane protein, protein processing extracellular domain, TMEM27, cleavage, human, beta cells, proteolysis, cell surface, membrane protein, hormone regulation, insulin secretion TMEM27, extracellular domain, cleavage, human beta cells, proteolytic processing, pancreatic beta cells, membrane protein, cell surface protein, protein cleavage, insulin secretion, cell signaling, protein structure TMEM27, extracellular domain, cleavage, human beta cells, proteolysis, islet cells, diabetes, insulin secretion, membrane protein, protease, beta cell function
1337	Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164. Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, ubiquitination, protein modification, DNA replication, DNA repair, post-translational modification, E2 enzyme, ubiquitin chain linkage Ubiquitin, ligase, UBC13, K63-linked, polyubiquitin, moiety, PCNA, K164, post-translational modification, DNA replication, DNA repair, ubiquitination pathway Ubiquitin ligase, UBC13, K63-linked, polyubiquitin, PCNA, K164, post-translational modification, DNA damage response, protein ubiquitination, E2 enzyme, DNA replication, repair mechanisms Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, post-translational modification, DNA repair, ubiquitination, protein degradation, DNA replication, signaling, E2 enzyme, DNA damage response Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, post-translational modification, DNA repair, ubiquitination pathway, E3 ligase, genome stability
232	Cataract and trachoma are the primary cause of blindness in Southern Sudan. Cataract, trachoma, blindness, Southern Sudan, eye diseases, ophthalmology, visual impairment, infectious diseases, tropical diseases, eye health cataract, trachoma, blindness, Southern Sudan, eye diseases, vision impairment, ophthalmology, infectious diseases, global health, tropical diseases Cataract, trachoma, blindness, Southern Sudan, eye diseases, visual impairment, infectious eye diseases, ophthalmology, public health, Africa Cataract, trachoma, blindness, Southern Sudan, eye diseases, visual impairment, ocular health, infectious eye diseases, public health, tropical medicine Cataract, Trachoma, blindness, Southern Sudan, eye diseases, ophthalmology, visual impairment, infectious diseases, poverty, healthcare, traditional medicine, surgery, prevention, treatment
1336	UCB T cells reduce TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, immune response, graft, immune reconstitution, T cell repertoire, immune modulation, hematopoietic stem cell transplant UCB, T cells, TCR diversity, transplantation, immune reconstitution, graft, immune response, alloimmune, immune suppression, graft-versus-host disease UCB, T cells, TCR diversity, transplantation, immune response, alloreactivity, immune reconstitution, T cell clonality, hematopoietic stem cell transplant, graft-versus-host disease, immune engraftment, T cell repertoire UCB, T cells, TCR diversity, transplantation, immune response, graft, immune reconstitution, immune tolerance, immune suppression, T cell clonality, hematopoietic stem cell transplant, immune monitoring, transplantation outcomes UCB, T cells, TCR diversity, transplantation, immune response, immune reconstitution, graft, immune tolerance, immune suppression, T cell clonality
233	Cell autonomous sex determination in somatic cells does not occur in Galliformes. cell, autonomous, sex determination, somatic cells, Galliformes, avian, reproductive biology, genetic mechanisms, sex chromosomes, sexual differentiation cell autonomous, sex determination, somatic cells, Galliformes, avian sex determination, sex differentiation, germ cells, genetic mechanisms, hormone influence, avian biology cell autonomous, sex determination, somatic cells, Galliformes, avian genetics, sex differentiation, sex chromosomes, sex determination mechanisms, avian biology, reproductive biology cell, autonomous, sex determination, somatic cells, Galliformes, avian, reproductive biology, genetics, sex differentiation, bird species cell autonomous sex determination, somatic cells, Galliformes, sex differentiation, avian species, gonadal development, sex chromosomes, sex determination mechanisms, non-autonomous, avian sex determination
354	Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis. Downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, tumor suppression, cell polarity, cancer progression, epithelial polarity, tumor suppressor genes Downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, tumor suppressor, cell polarity, epithelial tissue, cancer progression, cell signaling, tumor growth Downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, tumor suppression, cell polarity, oncogenesis, breast cancer, cellular localization, tumor development Downregulation,Scribble,mislocalization,cell transformation,mammary tumorigenesis,boolio,cell polarity,tumor suppressor,epithelial tissue,cancer development,cell adhesion,protein localization,molecular pathways,oncogenesis,cell signaling downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, tumor suppressor, cell polarity, cancer prevention, epithelial cells, tumor progression
475	Glycolysis is one of the primary glycometabolic pathways in cells. glycolysis, glycometabolism, metabolic pathways, cellular metabolism, carbohydrate metabolism, energy production, glucose breakdown, enzymatic pathway, ATP generation, cellular respiration glycolysis, glycometabolism, metabolic pathway, cellular metabolism, carbohydrate metabolism, glucose breakdown, energy production, aerobic glycolysis, anaerobic glycolysis, enzymatic pathway glycolysis, glycometabolism, cellular metabolism, metabolic pathways, glucose breakdown, anaerobic respiration, energy production, ATP generation, enzyme catalysis, biochemical pathway glycolysis, glycolytic pathway, glycometabolism, carbohydrate metabolism, cellular respiration, energy production, ATP, glucose, enzymatic pathway, metabolic pathway glycolysis, glycometabolic pathway, cellular metabolism, glucose catabolism, anaerobic, aerobic, energy production, ATP, intermediate compounds, metabolic process
113	Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. Angiotensin converting enzyme inhibitors, ACE inhibitors, renal insufficiency, kidney function, nephrotoxicity, renal risk, adverse effects, renal impairment, hypertension, cardiovascular drugs Angiotensin converting enzyme inhibitors, ACE inhibitors, renal insufficiency, kidney function, nephrotoxicity, adverse effects, hypertension, cardiovascular drugs, renal impairment, drug safety, renal failure, drug interactions Angiotensin converting enzyme inhibitors, ACE inhibitors, renal insufficiency, kidney function, nephrotoxicity, drug safety, renal impairment, blood pressure, hypertension, adverse effects, kidney toxicity Angiotensin converting enzyme inhibitors, ACE inhibitors, renal insufficiency, kidney function, adverse effects, nephrotoxicity, drug safety, renal impairment, hypertension, angiotensin, renal failure, medication risk Angiotensin converting enzyme inhibitors, ACE inhibitors, renal insufficiency, kidney function, nephrotoxicity, renal impairment, drug side effects, hypertension medication, renal risk, kidney failure
1335	UCB T cells maintain high TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, immune reconstitution, hematopoietic stem cell transplant, graft-versus-host disease, immune response, T cell repertoire, immune tolerance UCB, T cells, TCR, diversity, transplantation, immune reconstitution, hematopoietic stem cell, graft, immune response, immune tolerance UCB, T cells, TCR diversity, transplantation, immune reconstitution, immune response, graft-versus-host disease, lymphocyte diversity, hematopoietic stem cell transplantation, immune tolerance UCB, T cells, TCR diversity, transplantation, immune reconstitution, adoptive transfer, hematopoietic stem cells, graft-versus-host disease, T cell clonality, immune monitoring UCB, T cells, TCR diversity, transplantation, immune repertoire, hematopoietic stem cell transplant, graft, immune reconstitution, T cell persistence, T cell clonality
597	Incidence rates of cervical cancer have decreased. cervical cancer, incidence rates, decrease, epidemiology, risk factors, HPV, screening, vaccination, trends, mortality cervical cancer, incidence rates, decrease, epidemiology, screening, HPV, vaccination, trends, public health cervical cancer, incidence rates, decrease, epidemiology, trends, screening, HPV vaccination, risk factors, cervical neoplasia, public health incidence, rates, cervical cancer, decrease, trend, epidemiology, prevalence, statistics, reduction, screening, HPV, vaccination cervical cancer, incidence rates, decrease, prevalence, epidemiology, risk factors, screening, HPV, vaccination, trends
1213	The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases. monocytes, activation, deregulation, inflammation, inflammatory diseases, immune response, cytokines, chronic inflammation, immune system, pathological effects deregulation, monocytes, activation, prolonged, effects, inflammatory diseases, immune response, inflammation, immune cells, chronic inflammation, cytokines, immune regulation monocytes, activation, deregulation, inflammation, inflammatory diseases, prolonged activation, immune response, cytokines, chronic inflammation, immune regulation monocytes, activation, deregulation, inflammatory diseases, prolonged activation, immune response, inflammation, cytokines, immune regulation, pathogenesis monocytes, activation, deregulation, inflammation, inflammatory diseases, immune response, cytokines, immune cells, chronic inflammation, immune dysregulation
598	Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer. incidence rates, cervical cancer, increase, nationwide screening, cytology, detection, uterine cervical cancer incidence rates, cervical cancer, nationwide screening, cytology, uterine cervical cancer, screening programs, cancer detection, prevalence, epidemiology, diagnostic methods incidence rates, cervical cancer, screening programs, cytology, uterine cervical cancer, prevalence, diagnosis, early detection, epidemiology, public health incidence rates, cervical cancer, nationwide screening, cytology, uterine cervical cancer, detection, cancer screening, epidemiology, trends, screening programs cervical cancer, incidence rates, screening programs, cytology, uterine cervical cancer, detection, epidemiology, screening effectiveness, public health, cancer trends
115	Anthrax spores can be disposed of easily after they are dispersed. Anthrax, spores, disposal, decontamination, biohazard, safety, infectious agents, sterilization, containment, bioweapons, biological warfare, decontamination methods Anthrax, spores, disposal, decontamination, biohazard, bioterrorism, pathogen, sterilization, containment, decontamination methods Anthrax, spores, disposal, decontamination, bioterrorism, safety, sterilization, biohazard, containment, destruction, pathogen, biodefense anthrax, spores, disposal, biohazard, decontamination, bioweapons, contamination, safety, destruction, sterilization Anthrax, spores, disposal, decontamination, bioweapons, biosafety, pathogen, sterilization, biological hazards, infectious agents
236	Cell autonomous sex determination in somatic cells occurs in Passeriformes. cell, autonomous, sex determination, somatic cells, Passeriformes cell, autonomous, sex, determination, somatic, cells, Passeriformes cell autonomy, sex determination, somatic cells, Passeriformes, avian genetics, sex differentiation, sex chromosomes, reproductive biology, bird development, sex regulation cell, autonomous, sex determination, somatic cells, Passeriformes, avian, sex chromosomes, gonadal differentiation, genetic mechanisms, bird reproduction cell, autonomous, sex determination, somatic cells, Passeriformes, avian, genetics, reproductive biology, sexual development, gene regulation
478	Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol. Golli-deficient, T-cells, anergic phenotype, adaptive immune response, Ca2+ levels, cytosol, immune regulation, T-cell differentiation, calcium signaling, immune tolerance Golli-deficient, T-cells, differentiation, anergic phenotype, adaptive immune response, Ca2+ levels, cytosol, immune regulation, T-cell signaling, calcium signaling, immune tolerance Golli-deficient, T-cells, anergic phenotype, adaptive immune response, increased Ca2+, cytosol, T-cell differentiation, immune tolerance, calcium signaling, immune regulation Golli-deficient, T-cells, anergic phenotype, adaptive immune response, increased Ca2+, cytosol, immune regulation, T-cell differentiation, calcium signaling, immune tolerance Golli-deficient, T-cells, anergic phenotype, adaptive immune response, Ca2+ increase, cytosol, T-cell differentiation, immune regulation, calcium signaling, immune tolerance
1332	Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10. Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, cytokines, IL-6, IL-10, immune response, inflammation, cytokine regulation Tumor necrosis factor-alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, cytokine inhibition, IL-6, IL-10, immune response, inflammation, cytokine signaling Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, IL-6, IL-10, cytokine inhibition, immune response, inflammation pathways Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, cytokines, pro-inflammatory, IL-6, IL-10, immune response, inflammation, cytokine inhibition Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, IL-6, IL-10, cytokine inhibition, immune response, inflammation
237	Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis. Cells, clpC, sporulation, efficiency, defect, Bacillus subtilis ClpC, sporulation, Bacillus subtilis, cell differentiation, sporulation defect, protein quality control, cellular stress response, bacterial genetics, sporulation efficiency, genetic mutation ClpC, sporulation, Bacillus subtilis, cell division, sporulation defect, protein quality control, chaperone, stress response, genetic mutation, sporulation efficiency Cells, clpC, sporulation, Bacillus subtilis, defect, efficiency, gene regulation, protein degradation, sporulation pathway, bacterial differentiation ClpC, sporulation, Bacillus subtilis, cell differentiation, protein degradation, sporulation defect, genetic mutation, bacterial sporulation, cellular processes, chaperone proteins
238	Cells undergoing methionine restriction may activate miRNAs. cells, methionine restriction, miRNAs, gene regulation, cellular response, metabolic pathways, epigenetics, microRNA activation, amino acid deprivation, cellular stress, molecular mechanisms cells, methionine restriction, miRNAs, activation, gene regulation, nutrition, cellular response, epigenetics, metabolic pathways, microRNA, cell signaling, amino acid metabolism cells, methionine restriction, miRNAs, activation, gene regulation, metabolism, epigenetics, cellular response, nutrient deprivation, microRNAs cells, methionine restriction, miRNAs, gene regulation, cellular metabolism, microRNAs, nutrient deprivation, epigenetics, gene expression, cellular response cells, methionine restriction, miRNAs, gene regulation, cell metabolism, microRNAs, nutrient sensing, epigenetics, apoptosis, cellular response
118	Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile antibiotics, gut microbiome, Clostridium difficile, antibiotic resistance, microbiota alterations, gut health, pathogen resistance, microbial diversity, antimicrobial effects, dysbiosis, colonization resistance, bacterial interactions antibiotics, gut microbiome, microbiota alteration, Clostridium difficile, antimicrobial resistance, dysbiosis, microbiome diversity, pathogen resistance, microbiota disruption, antibiotic resistance, gut health, microbiome composition antibiotics, gut microbiome, microbiota diversity, Clostridium difficile, antibiotic resistance, dysbiosis, antibiotic effects, microbial imbalance, gut health, pathogen susceptibility antibiotics, gut microbiome, microbiota, antibiotic resistance, Clostridium difficile, dysbiosis, antimicrobial impact, microbial diversity, pathogen suppression, microbiome disruption Antibiotics, gut microbiome, Clostridium difficile, resistance, microbiota alterations, antibiotic impact, gut health, pathogenic bacteria, microbial diversity, antibiotic resistance, microbiome disruption
239	Cellular aging closely links to an older appearance. cellular aging, skin aging, aging process, appearance, age-related changes, dermal aging, cellular damage, collagen decline, oxidative stress, wrinkle formation, skin elasticity, biological aging, photodamage, telomeres, senescence cellular aging, aging process, skin aging, appearance, signs of aging, aging skin, wrinkle formation, telomeres, oxidative stress, collagen degradation, aging markers, skin elasticity, age-related changes cellular aging, aging process, appearance, skin aging, wrinkles, cellular degeneration, telomeres, oxidative stress, collagen loss, youthfulness, biomarkers, skin elasticity, senescence, lifespan, dermatology cellular aging, aging process, skin aging, older appearance, cellular senescence, skin care, anti-aging, dermatology, age-related changes, collagen loss, oxidative stress, telomeres, skincare treatments, biological aging, cosmetic dermatology cellular aging, skin aging, appearance, aging process, wrinkles, skin elasticity, collagen degradation, cellular senescence, oxidative stress, telomeres
911	PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice. PKG-la, pain hypersensitivity, PGK-la knockout, gene expression, nociception, signaling pathway, knockout mice, pain, molecular mechanism, analgesia, neuropathic pain PKG-la, pain hypersensitivity, PGK-la knockout, gene expression, signal transduction, nociception, molecular pathways, knockout mice, pain signaling, cyclic GMP, neuronal, pain modulation PKG-la, pain hypersensitivity, PGK-la knockout, expression, role, signaling pathways, nociception, pain modulation, knockout mice, molecular mechanisms PKG-la, pain hypersensitivity, PGK-la knockout mice, signal transduction, nociception, gene expression, pain pathways, knockout model, sensory neurons, pain modulation PKG-la, pain hypersensitivity, PGK-la knockout, expression, role, signaling pathway, nociception, genetic knockout, mouse model, pain modulation
913	PPAR-RXRs are inhibited by PPAR ligands. PPAR-RXRs, PPAR ligands, nuclear receptors, transcription factors, ligand binding, receptor inhibition, gene regulation, PPAR signaling, RXR antagonists, molecular pathways PPAR, RXR, inhibition, PPAR ligands, nuclear receptors, transcription factors, heterodimerization, gene expression, ligand binding, receptor activity PPAR, RXRs, inhibition, ligands, nuclear receptors, PPAR activation, receptor binding, ligand binding, transcription regulation, gene expression, nuclear receptor signaling PPAR-RXRs, inhibition, PPAR ligands, nuclear receptors, transcription factors, ligand binding, gene regulation, receptor signaling PPAR-RXR, PPAR ligands, inhibition, nuclear receptors, transcription factors, ligand binding, receptor dimerization, gene regulation, agonists, antagonists
914	PPAR-RXRs can be activated by PPAR ligands. PPAR, RXR, activation, ligands, nuclear receptors, transcription factors, gene regulation, ligand binding, receptor heterodimers, PPAR subtypes PPAR-RXRs, activation, PPAR ligands, nuclear receptors, gene expression, transcription factors, lipid metabolism, PPAR subtypes, receptor signaling, ligand binding PPAR-RXRs, activation, PPAR ligands, nuclear receptors, transcription factors, gene regulation, lipid metabolism, receptor signaling, ligand binding, nuclear receptor family PPAR, RXRs, activation, ligands, nuclear receptors, gene regulation, transcription factors, ligand binding, PPAR subtypes, receptor heterodimerization PPAR, RXRs, activation, ligands, nuclear receptors, PPAR-RXR heterodimer, gene transcription, ligand binding, receptor activation, molecular signaling
1339	Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion. ultrasound guidance, needle insertion, traumatic procedures, medical imaging, minimally invasive, procedural safety, diagnostics, intervention, medical techniques, clinical outcomes ultrasound, guidance, traumatic procedures, needle insertion, medical imaging, procedure safety, complication rate, minimally invasive, real-time imaging, procedural accuracy, patient safety ultrasound guidance, traumatic procedures, needle insertion, procedural safety, complication rates, image-guided interventions, medical imaging, diagnostic procedures, procedural accuracy, risk assessment ultrasound guidance, needle insertion, traumatic procedures, increased risk, image-guided procedures, procedure complications, diagnostic accuracy, interventional ultrasound, procedural safety ultrasound guidance, traumatic procedures, needle insertion, medical imaging, procedure safety, complication rate, minimally invasive, diagnostic accuracy, procedural success, clinician training
13	5% of perinatal mortality is due to low birth weight. perinatal mortality, low birth weight, perinatal death causes, fetal growth restriction, neonatal mortality, birth weight significance, pregnancy outcomes, infant mortality factors, low birth weight complications, perinatal health perinatal mortality, low birth weight, birth outcomes, fetal development, neonatal health, infant mortality, risk factors, pregnancy complications, prenatal care, perinatal deaths perinatal mortality, low birth weight, perinatal deaths, fetal weight, neonatal outcomes, infant mortality, birth weight factors, perinatal health, neonatal mortality, pregnancy outcomes perinatal mortality, low birth weight, infant mortality, fetal health, neonatal outcomes, birth weight, prenatal factors, neonatal mortality, perinatal health, pregnancy risk factors perinatal mortality, low birth weight, fetal health, neonatal outcomes, infant mortality, birth weight, perinatal statistics, maternal health, pregnancy outcomes, fetal development
1110	Suboptimal nutrition is not predictive of chronic disease suboptimal, nutrition, predictive, chronic disease, health, diet, long-term health, nutrition science, disease risk, lifestyle, health outcomes nutrition, suboptimal, predictive, chronic disease, health outcomes, diet, nutrition status, long-term health, disease risk, metabolic health suboptimal nutrition, predictive, chronic disease, nutrition, health outcomes, dietary patterns, disease risk, health prediction, nutrition impact, chronic illness suboptimal, nutrition, predictive, chronic, disease, health, diet, health outcomes, risk factors, nutritional deficiencies, disease prevention nutrition, suboptimal, predictive, chronic disease, health outcomes, diet, disease risk, nutritional status, long-term health, disease prevention
1352	Upregulation of mosGCTL-1 is induced upon infection with West Nile virus. mosGCTL-1, upregulation, infection, West Nile virus, immune response, mosquito vector, mosquito immunity, virus-vector interaction, gene expression, pathogen recognition Upregulation, mosGCTL-1, infection, West Nile virus, immune response, vector competence, mosquito immune genes, viral replication, gene expression, mosquito-virus interaction mosGCTL-1, upregulation, infection, West Nile virus, immune response, mosquito, gene expression, viral replication, vector competence, pathogen recognition Upregulation, mosGCTL-1, gene expression, infection, West Nile virus, immune response, viral infection, mosquito, Culex, vector, innate immunity, gene regulation Upregulation, mosGCTL-1, gene expression, West Nile virus, infection, immune response, mosquito vector, viral replication, gene regulation, innate immunity
362	During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells. primary antibody response, B cells, migration, paracortical areas, oxysterol, stromal cells, activation, immune response, lymph node, germinal centers antibody response, activated B cells, migration, paracortical areas, oxysterol accumulation, stromal cells, lymph node, immune response, secondary lymphoid tissues, immune cell trafficking early antibody response, activated B cells, migration, paracortical areas, oxysterol accumulation, stromal cells, lymph node, immune response, B cell activation, lymphoid tissue, chemokines, immune cell trafficking antibody response, activated B cells, migration, paracortical areas, oxysterol, stromal cells, immune response, lymph node, lymphoid tissue, cell migration, chemotaxis, immune regulation primary, early antibody response, activated B cells, migration, paracortical areas, oxysterol accumulation, stromal cells, immune response, lymph node, germinal centers, chemotaxis, immune microenvironment
1107	Subcutaneous fat depots undergo extensive browning processes after cold exposure. subcutaneous fat, fat depots, browning, cold exposure, thermogenic adipose tissue, beige fat, brown adipose tissue, thermogenesis, fat metabolism, cold-induced browning subcutaneous fat, browning, adipose tissue, cold exposure, thermogenesis, beige fat, BMI, white adipose tissue, brown fat, energy expenditure subcutaneous fat, fat depots, browning, cold exposure, thermogenesis, adipose tissue, brown fat, beige fat, temperature, calorie expenditure, metabolic adaptation, adipocyte differentiation subcutaneous fat, depots, browning, cold exposure, thermogenesis, adipose tissue, beige fat, brown fat, metabolic adaptation, cold-induced thermogenesis subcutaneous fat, fat depots, browning, cold exposure, adipose tissue, thermogenesis, beige fat, brown adipose tissue, temperature, metabolic adaptation
1	0-dimensional biomaterials show inductive properties. 0-dimensional,nanomaterials,biomaterials,inductive properties,nano-sized,zero-dimensional,biological materials,material properties,nanotechnology,biomedical applications 0-dimensional, nanomaterials, biomaterials, inductive properties, nanostructures, conductive materials, nanoparticles, electrical conductivity, electromagnetic induction, materials science 0-dimensional, biomaterials, inductive properties, nanomaterials, zero-dimensional, nanostructures, electronic properties, surface effects, quantum dots, material sciences 0-dimensional, biomaterials, inductive properties, nanoscale, nanomaterials, quantum dots, nanoparticles, electronic properties, conductive, material science 0-dimensional, biomaterials, inductive properties, nanomaterials, quantum dots, quantum confinement, nanoscale, zero-dimensional, nanostructures, material properties, inductive response
1226	The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers. TET protein, loss of function, biological consequences, myeloid cancers, epigenetics, DNA demethylation, hematologic malignancies, TET mutations, cancer biology, gene regulation TET proteins, loss, function, biological consequences, myeloid cancers, epigenetics, DNA methylation, tumorigenesis, hematological malignancies, gene regulation TET proteins, DNA demethylation, epigenetics, myeloid cancers, leukemia, genetic mutations, gene regulation, hematopoiesis, cancer biology, tumor suppressors TET protein, loss, functions, biological consequences, myeloid cancers, DNA methylation, epigenetics, hematopoiesis, gene regulation, tumorigenesis, cancer, mutations, TET family, 5-hydroxymethylcytosine, genome stability TET protein, loss, dysfunction, biological consequences, myeloid cancers, leukemia, epigenetics, DNA demethylation, gene regulation, hematologic malignancies
1104	Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin. stroke, patients, direct oral anticoagulants, warfarin, in-hospital mortality, risk, prior use, comparison stroke, patients, direct oral anticoagulants, DOACs, warfarin, in-hospital mortality, prior use, risk, comparison, anticoagulation, stroke outcomes stroke, patients, prior use, direct oral anticoagulants, warfarin, in-hospital mortality, risk, comparison, anticoagulation therapy stroke, patients, direct oral anticoagulants, DOACs, warfarin, in-hospital mortality, prior use, risk, comparison, outcome, anticoagulation therapy stroke, patients, prior use, direct oral anticoagulants, warfarin, in-hospital mortality, risk, comparative, anticoagulation therapy
1225	The locus rs647161 is associated with colorectal carcinoma. locus, rs647161, genetic association, colorectal carcinoma, colorectal cancer, SNP, single nucleotide polymorphism, genetic markers, cancer genetics, colorectal tumor, genome-wide association study, GWAS rs647161, locus, genetic association, colorectal carcinoma, colorectal cancer, SNP, cancer genetics, genomic marker, susceptibility, colorectal tumor, disease risk locus, rs647161, genetic association, colorectal carcinoma, colorectal cancer, SNP, single nucleotide polymorphism, genetic marker, cancer genomics, colorectal tumor, genetic susceptibility locus, rs647161, genetic variation, colorectal cancer, colorectal carcinoma, SNP, genetic association, genome, cancer risk, colorectal neoplasm locus, rs647161, genetic association, colorectal carcinoma, colorectal cancer, SNP, single nucleotide polymorphism, genetic marker, cancer genetics, colon cancer, genetic predisposition
124	Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. Antiretroviral therapy, HIV, tuberculosis, TB, CD4 count, immunodeficiency, coinfection, treatment outcomes, antimicrobial resistance, viral suppression, immune reconstitution, infectious diseases, public health antiretroviral therapy, HIV, TB, tuberculosis, CD4 count, immunodeficiency, co-infection, ART, treatment effectiveness, disease progression, immune response Antiretroviral therapy, tuberculosis, CD4 counts, HIV, co-infection, treatment efficacy, immune response, ART, TB prevention, immune suppression, clinical outcomes Antiretroviral therapy, ART, tuberculosis, TB, HIV, CD4 count, immune suppression, co-infection, treatment efficacy, disease progression, viral suppression, HIV/AIDS, immune restoration, clinical outcomes, public health antiretroviral therapy, ART, tuberculosis, TB, CD4 counts, HIV, co-infection, immune response, treatment efficacy, immunodeficiency, disease progression, viral suppression
3	1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. genomes, genetic variation, rare variants, penetrance, genetic mapping, genome project, sequence variation, genetic diversity, human genomics, variant effects genomes project, genetic sequence variation, rare variants, penetrance effects, common variants, genetic mapping, genome diversity, variant effects, population genetics, genomics research genomes, genetic variation, rare variants, penetrance, genetic mapping, population genomics, genetic diversity, sequencing, human genetics, genotype-phenotype, genetic epidemiology genomes, genetic variation, rare variants, penetrance, common variants, genetic mapping, genome sequencing, genetic diversity, population genetics, disease association, variant effects 1,000 genomes, genetic variation, rare variants, penetrance, genetic mapping, sequence variation, genomic diversity, population genetics, genetic research, genome sequencing
1344	Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging. p53 pathway, up-regulation, molecular events, cancer resistance, lifespan, senescent cells, aging, organismal aging, molecular pathways, cellular senescence, tumor suppression, DNA damage response, apoptosis, cellular aging p53 pathway, up-regulation, cancer resistance, molecular events, senescent cells, aging, organismal aging, lifespan, cellular senescence, molecular biology, cancer, genomics, aging biomarkers, cell cycle, apoptosis, DNA damage, tumor suppressor, molecular mechanisms p53 pathway, up-regulation, cancer resistance, molecular events, senescence, aging, lifespan, cellular senescence, organismal aging, molecular signaling, tumor suppression, cell cycle arrest, DNA damage response p53 pathway, up-regulation, molecular events, cancer resistance, lifespan, senescent cells, organismal aging, cellular senescence, molecular mechanisms, aging biomarkers, tumor suppression, DNA damage response, cellular aging, apoptosis, gene expression, cellular senescence theory p53, up-regulation, pathway, molecular events, cancer resistance, lifespan, senescent cells, aging, organismal aging, cellular senescence, molecular mechanisms, tumor suppression, cellular aging, genetic pathways
5	1/2000 in UK have abnormal PrP positivity. UK, abnormal PrP positivity, prevalence, prion protein, 1/2000, neurodegenerative diseases, prion diseases, transmissible spongiform encephalopathies, epidemiology, pathology, biomarker PrP, positivity, abnormal, prevalence, UK, prion, neurodegeneration, transmissible spongiform encephalopathy, TSE, prion diseases, epidemiology, prion protein, disease incidence PrP, abnormal PrP, positivity, prevalence, UK, prion protein, neurodegeneration, transmissible spongiform encephalopathies, TSE, prion diseases, epidemiology, genetic mutation, disease prevalence PrP positivity, abnormal PrP, UK, prevalence, prion diseases, transmissible spongiform encephalopathies, epidemiology, incidence rate, prion protein, neuropathology PrP positivity, abnormal PrP, prevalence, UK, prion diseases, prion protein, neurodegenerative disorders, PrP testing, UK population, disease epidemiology
127	Arginine 90 in p150n is important for interaction with EB1. Arginine, p150n, EB1, amino acid, protein interaction, mutation, binding site, cellular transport, cytoskeleton, microtubules Arginine, p150n, EB1, amino acid, protein interaction, mutation, binding site, microtubules, cytoskeleton, cellular transport Arginine, p150n, EB1, protein interaction, amino acid, 90th residue, microtubule, cytoskeleton, binding site, cellular function Arginine, p150n, EB1, protein interaction, amino acid, residue 90, microtubules, cytoskeleton, binding site, molecular biology, cell biology Arginine, p150n, EB1, amino acid, protein interaction, molecular biology, cytoskeleton, microtubules, protein binding, cellular functions
248	Chenodeosycholic acid treatment increases whole-body energy expenditure. chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, fatty acid oxidation, mitochondrial activity, metabolic rate, liver metabolism, lipid metabolism Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, liver, obesity, metabolic rate, brown adipose tissue, lipid metabolism, mitochondrial activity, thermogenic response chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, liver function, lipid metabolism, mitochondrial activity, obesity, metabolic rate Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, pharmacology, thermogenesis, lipid metabolism, glucagon, mitochondrial activity, liver function Chenodeoxycholic acid, energy expenditure, metabolic rate, bile acids, lipid metabolism, thermogenesis, liver function, cholesterol, mitochondrial activity, pharmacology
1100	Statins increase blood cholesterol. statins, blood cholesterol, lipid-lowering, hyperlipidemia, cardiovascular health, cholesterol levels, statin therapy, HDL, LDL, triglycerides Statins, cholesterol, blood, lipid-lowering, hyperlipidemia, cardiovascular risk, LDL, HDL, plaque, statin efficacy Statins, blood cholesterol, lipid-lowering, hyperlipidemia, cardiovascular risk, LDL, HDL, HMG-CoA reductase inhibitors, cholesterol management, statin therapy Statins, blood cholesterol, lipid lowering, hyperlipidemia, cardiovascular risk, LDL reduction, HDL effects, cholesterol management, statin therapy, lipid profile statins, cholesterol, blood, increase, lipid-lowering, cardiovascular, HDL, LDL, hyperlipidemia, medication
1221	The genomic aberrations found in matasteses are very similar to those found in the primary tumor. genomic aberrations, metastases, primary tumor, genetic similarities, tumor progression, cancer genomics, mutation profile, metastatic cancer, tumor genetics genomic aberrations, metastases, primary tumor, genetic mutations, tumor similarity, cancer genetics, tumor progression, genomic analysis, metastatic cancer, tumor heterogeneity genomic aberrations, metastases, primary tumor, genetic similarity, tumor evolution, cancer genomics, tumor heterogeneity, genetic mutations, metastatic cancer, tumor progression genomic aberrations, metastases, primary tumor, genetic similarity, tumor genetics, cancer genomics, tumor progression, genetic mutations, metastatic cancer, tumor comparison genomic aberrations, metastases, primary tumor, genetic similarity, tumor genetics, cancer genomics, genetic mutations, tumor progression, metastatic tumors, genomic profiling
128	Arterioles have a larger lumen diameter than venules. Arterioles, venules, lumen diameter, vessel size, microcirculation, blood vessels, arterial, venous, vascular structure, small arteries, small veins arterioles, venules, lumenDiameter, vesselSize, microcirculation, blood vessels, vasculature, vascular anatomy, small arteries, small veins arterioles, venules, lumen diameter, microcirculation, blood vessels, vascular structure, vessel size, arteriole, venule, microvasculature arterioles, venules, lumen diameter, blood vessels, microcirculation, vascular anatomy, vessel size, capillaries, vascular structure arterioles, venules, lumen diameter, blood vessels, microcirculation, vessel size, vascular anatomy, vessel comparison, arteriolar structure, venular structure
249	Chenodeosycholic acid treatment reduces whole-body energy expenditure. Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, lipid metabolism, metabolic rate, treatment, obesity, cholesterol, liver function, gut microbiota Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, liver function, thermogenesis, metabolic rate, fat metabolism, cholesterol, digestive system chenodeoxycholic acid, energy expenditure, metabolism, bile acids, lipid metabolism, thermogenesis, mitochondrial activity, weight loss, obesity, pharmacology Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, hepatic function, lipid metabolism, obesity, metabolic syndrome, pharmacology chenodeoxycholic acid, energy expenditure, metabolism, bile acids, lipid metabolism, thermogenesis, hepatic function, pharmacology, obesity, energy homeostasis
129	Articles published in open access format are less likely to be cited than traditional journals. open access, citation rates, traditional journals, scholarly publishing, open access articles, academic citations, publication formats, research dissemination, open access benefits, journal impact open access, citations, traditional journals, article impact, scholarly publishing, open access impact, citation rates, publication formats, open access advantages, journal influence open access, citation impact, publication format, traditional journals, scholarly articles, citation frequency, open access publishing, research visibility, academic publishing, citation metrics open access, citation rates, traditional journals, scholarly publishing, open access advantages, citation impact, research dissemination, academic visibility, journal impact, open access versus subscription open access, citation, traditional journals, publication impact, research visibility, article accessibility, citation rate, open access benefits, academic publishing, scholarly communication
800	Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis. epigenome, brain, aging, genes, neurogenesis, gene regulation, epigenetic modifications, neurobiology, brain aging, gene expression, neural development, epigenetic therapy epigenome, brain, aging, genes, neurogenesis, gene regulation, epigenetic modifications, neural plasticity, gene expression, age-related changes, DNA methylation, histone modification, neural development, cognitive decline epigenome, brain, human aging, neurogenesis, gene regulation, epigenetic modification, neural plasticity, age-related genes, gene expression, aging process, neural development, methylation, histone modification epigenome, brain, aging, human, neurogenesis, gene expression, epigenetic modification, neural plasticity, age-related genes, gene regulation, neurodevelopment, DNA methylation, histone modification, cognitive decline, aging process, neural regeneration epigenome, brain, aging, genes, neurogenesis, modification, gene expression, epigenetic regulation, neuroplasticity, neuronal development, age-related changes, brain aging, gene regulation, DNA methylation, histone modification
921	Participating in six months of physical activity improves cognitive functioning. physical activity, cognitive functioning, six months, exercise, mental health, brain health, cognitive benefits, physical fitness, long-term effects, mental performance physical activity, cognitive functioning, six months, exercise benefits, mental health, cognitive improvement, physical exercise, brain health, long-term activity, mental performance physical activity, cognitive functioning, six months, exercise, mental health, brain health, physical fitness, cognitive improvement, long-term exercise, mental sharpness physical activity, cognitive functioning, six months, exercise, mental health, brain health, cognition, fitness, neuroplasticity, long-term effects physical activity, cognitive functioning, six months, exercise, mental health, brain health, cognition, fitness, physical training, long-term effects
922	Patients in stable partnerships have a faster progression from HIV to AIDS. HIV, AIDS, disease progression, stable partnerships, relationship status, HIV progression, disease advancement, patient factors, social support, sexual partnership, health outcomes, epidemiology HIV, AIDS, stable partnerships, disease progression, seroconversion, social relationships, immune response, HIV progression, partner stability, disease progression factors HIV, AIDS, disease progression, stable partnerships, relationship status, HIV progression rate, sexual health, seroconversion, epidemiology, clinical outcomes HIV, AIDS, disease progression, stable relationships, partnership stability, HIV progression, AIDS development, patient health, HIV transmission, sexual partnerships HIV, AIDS, disease progression, stable partnerships, relationship status, infection rate, immune response, epidemiology, transmission, progression factors
805	Monoclonal antibody targeting of N-cadherin inhibits metastasis. monoclonal antibody,N-cadherin,metastasis,cell adhesion,cancer therapy,tumor progression,adhesion molecule,cell signaling,metastatic inhibition,biological target,therapeutic antibodies monoclonal antibody, N-cadherin, metastasis, cancer, inhibition, cell adhesion, tumor spread, therapeutic target, oncology, metastasis inhibition monoclonal antibody,N-cadherin,metastasis,inhibition,cancer,cell adhesion,therapeutics,biomarkers,cell migration,metastatic spread monoclonal antibody, N-cadherin, metastasis, cancer, cell adhesion, tumor spread, therapy, targeting, adhesion molecules, metastasis inhibition monoclonal antibody,N-cadherin,metastasis,inhibition,cancer,adhesion,cell migration,cell adhesion,therapeutic antibodies,metastatic cancer,cell signaling,adhesion molecules,metastasis suppression
808	Most termination events in Okazaki fragments are sequence specific. Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, DNA synthesis, replication fork, DNA polymerase, fragmentation, DNA sequences Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, DNA synthesis, replication fork, DNA polymerase, DNA sequencing, molecular biology Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, DNA synthesis, replication fork, DNA polymerase, primer removal, late stage replication Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, replication fork, DNA synthesis, DNA polymerase, replication termination, replication process Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand synthesis, DNA polymerase, replication fork, DNA sequence, genetic stability, replication termination
1121	Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites. synaptic activity, brain-derived neurotrophic factor, BDNF, postsynaptic dendrites, local release, neuroplasticity, synaptic transmission, dendritic signaling, neurotrophic factors, neural plasticity synaptic activity, brain-derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotrophic factors, synaptic transmission, neuronal signaling, dendritic processes, neuroplasticity synaptic activity, brain derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, synaptic transmission, neuroplasticity, neural signaling, neurotrophic factors, dendritic secretion, synaptic plasticity synaptic activity, brain-derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotransmission, synaptic plasticity, neurotrophic signaling, dendritic release, synaptic regulation synaptic activity, brain-derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotrophic factors, neuronal signaling, synaptic transmission, dendritic release, neuroplasticity
1363	Venules have a thinner or absent smooth layer compared to arterioles. venules, arterioles, smooth muscle, vessel layers, vessel thickness, vascular structure, capillaries, blood vessels, vessel walls, microcirculation, vessel morphology venules, arterioles, smooth muscle, vessel wall, vessel thickness, vessel structure, capillaries, vascular layers, blood vessels, vessel anatomy venules, smooth muscle, arterioles, vessel wall, vessel structure, vascular layers, tunica media, vessel comparison, vessel anatomy, vessel thickness venules, arterioles, vascular structure, smooth muscle layer, vessel wall, microcirculation, vessel wall thickness, vascular anatomy, capillaries, blood vessel comparison venules, thinner wall, absence, smooth muscle, arterioles, vessel structure, vascular layers, blood vessels, microcirculation, vascular anatomy
1241	The myocardial lineage develops from cardiac progenitors of mesodermal origin. myocardial, lineage, cardiac, progenitors, mesodermal, development, origins, heart, embryogenesis, progenitor cells myocardial lineage, cardiac progenitors, mesodermal origin, heart development, stem cells, cardiac differentiation, embryonic development, myocardium formation myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiac differentiation, embryonic heart, cardiac mesoderm, heart progenitor cells, cardiac muscle formation, embryogenesis myocardial lineage, cardiac progenitors, mesodermal origin, cardiac development, heart formation, cardiac differentiation, embryonic stem cells, cardiovascular development, myocardial progenitors, cardiac mesoderm myocardial, lineage, cardiac, progenitors, mesodermal, development, origin, heart, embryology, cardiac development
1362	Venules have a larger lumen diameter than arterioles. venules, arterioles, lumen diameter, blood vessels, microcirculation, vessel size, vascular structure, vascular hierarchy, vasculature, microvascular anatomy venules, lumen diameter, arterioles, vascular anatomy, microcirculation, blood vessels, vessel size, vascular hierarchy, circulatory system, vessel comparison venules, arterioles, lumen diameter, blood vessels, vessel size, microcirculation, vessel comparison, vascular anatomy, vessel diameter venules, lumen diameter, arterioles, vessel size, blood vessels, microcirculation, vessel anatomy, vascular structure, capillaries, blood flow Venules, lumen diameter, arterioles, blood vessels, vascular anatomy, vessel size, microcirculation, vessel comparison, vascular hierarchy
491	HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years HNF4A, mutations, diabetes, genetic mutations, juvenile diabetes, maturity-onset diabetes of the young, MODY, hereditary, gene, carriers, age of onset, pediatric diabetes, HNF4A gene, inheritable, genetic disorder, early-onset diabetes HNF4A, mutations, diabetes, mutant carriers, age 14, genetic mutations, monogenic diabetes, MODY, hereditary diabetes, gene mutation, early-onset diabetes HNF4A, mutations, diabetes, genetic, hereditary, adolescence, early-onset, gene, carrier, inheritance HNF4A, mutations, diabetes, genetic mutations, juvenile diabetes, maturity-onset diabetes of the young, MODY, genetic disorders, age of onset, hereditary, insulin regulation, pancreatic beta cells, genetic predisposition HNF4A, mutations, diabetes, genotype-phenotype, early-onset, genetic disorders, maturity-onset diabetes of the young, MODY, hereditary, age of onset, genetic testing
130	Articles published in open access format are more likely to be cited than traditional journals. open access, citation, scholarly articles, traditional journals, article impact, open access publishing, citation advantage, research dissemination, journal type, open access benefits open access, traditional journals, citation rates, scholarly articles, publication impact, open access publishing, academic citations, research dissemination, open access benefits, journal comparison open access, citation, traditional journals, scholarly articles, open access benefits, research visibility, citation advantage, open access publishing, scholarly communication, academic dissemination open access, citation rate, traditional journals, publication format, scholarly articles, open access publishing, citation likelihood, journal comparison, academic publishing, open access benefits open access, citations, traditional journals, scholarly publishing, research impact, open access articles, citation advantage, publication format, academic publishing, open access benefits
132	Aspirin inhibits the production of PGE2. Aspirin, inhibition, PGE2, prostaglandin E2, cyclooxygenase, COX, anti-inflammatory, analgesic, prostaglandins, synthesis, enzyme Aspirin, PGE2, prostaglandin E2, inhibition, cyclooxygenase, COX, inflammation, analgesic, antipyretic, prostaglandins, eicosanoids Aspirin, PGE2, prostaglandin E2, inhibition, cyclooxygenase, COX, inflammation, analgesic, antipyretic, prostaglandins, enzyme, biosynthesis Aspirin, PGE2, prostaglandins, cyclooxygenase, COX, inflammation, analgesic, antipyretic, inhibit, biosynthesis Aspirin, inhibits, production, PGE2, prostaglandin E2, cyclooxygenase, COX-1, COX-2, anti-inflammatory, analgesic, NSAID
133	Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, focal generation, Src kinase, nonreceptor tyrosine kinase, cell invasion, cytoskeleton, actin, signaling pathway, membrane dynamics, phosphorylation, cancer metastasis, proteolysis invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, focal generation, Src kinase, nonreceptor tyrosine kinase, cell invasion, cytoskeleton, actin remodeling invadopodia, assembly, focal generation, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, activation, nonreceptor tyrosine kinase, Src, cell invasion, cancer metastasis, actin cytoskeleton, signaling pathways, membrane dynamics invadopodia, assembly, focal generation, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, activation, nonreceptor tyrosine kinase, Src, cell invasion, membrane dynamics, signaling pathways, cytoskeleton remodeling, tumor metastasis invadopodia, assembly, focal generation, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, activation, nonreceptor tyrosine kinase, Src, cell invasion, kinase signaling, cytoskeletal rearrangement, cancer metastasis
1359	Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. Varenicline, monotherapy, efficacy, comparison, nicotine replacement, combination therapy, bupropion, 12 weeks, smoking cessation, treatment outcomes Varenicline, monotherapy, nicotine replacement therapy, combination therapy, bupropion, smoking cessation, treatment duration, effectiveness, 12 weeks, pharmacotherapy, comparative study Varenicline, monotherapy, combination therapy, nicotine replacement, bupropion, smoking cessation, treatment duration, efficacy, comparative study, 12 weeks Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination therapy, nicotine replacement, NRT, bupropion, smoking cessation, efficacy comparison Varenicline, monotherapy, nicotine replacement therapy, combination, bupropion, effectiveness, 12 weeks, smoking cessation, treatment comparison
137	Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. asymptomatic, visual impairment, screening, elderly, populations, vision, improvement, healthcare, prevention, early detection asymptomatic, visual impairment, screening, elderly, aging, prevention, vision correction, public health, health outcomes, early detection, ocular health, preventative care asymptomatic, visual impairment, screening, elderly, populations, vision, improvement, health outcomes, preventative care, ophthalmology, public health asymptomatic visual impairment, screening, elderly, aging, vision, eye health, preventative care, visual acuity, ophthalmology, diagnostic testing, public health, health outcomes, population health, screening efficacy asymptomatic, visual impairment, screening, elderly, aging, prevention, vision loss, healthcare, early detection, ophthalmology, public health, preventative measures, health outcomes
1232	The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease. FOXO3, G allele, Crohn's Disease, genetic markers, severity, symptom correlation, minor allele, inflammatory bowel disease, genetic predisposition, disease severity factors FOXO3, G allele, Crohn's Disease, genetic, severity, symptoms, polymorphism, minor allele, inflammation, immune response FOXO3, G allele, Crohn's Disease, genetic variation, severity, symptoms, minor allele, genetic association, inflammation, immune response FOXO3, G allele, Crohn's Disease, genetic variation, symptom severity, minor allele, inflammation, immune response, disease progression, genetics, susceptibility FOXO3, G allele, Crohn's Disease, genetic variation, severity, symptoms, minor allele, polymorphism, genetic association, inflammatory bowel disease, immune response, disease manifestation
811	Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals. Mutant mice, SVCT2, ascorbic acid, brain, adrenal glands, vitamin C, transporter deficiency, genetic modification, oxidative stress, neurochemistry, endocrine system Mutant mice, SVCT2, ascorbic acid, brain, adrenals, vitamin C, transporter deficiency, oxidative stress, tissue levels, genetic modification Mutant mice, SVCT2, ascorbic acid, brain, adrenals, increased levels, vitamin C transporter, knockout, neurobiology, adrenal glands, oxidative stress, vitamin C deficiency Mutant mice, SVCT2, ascorbic acid, brain, adrenals, vitamin C, knockout, oxidative stress, neurobiology, adrenal glands Mutant mice, SVCT2, ascorbic acid, brain, adrenals, vitamin C transporter, knockout, increased levels, vitamin C, neuroendocrine, oxidative stress, gene deletion
814	Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. GNB2, mutations, G-Beta protein, G-beta, G-protein, GNB2 mutations, cancer, oncogenesis, G-alpha, AKT pathway, signal transduction, protein interaction, molecular signaling, cancer genetics, cell signaling GNB2, mutations, G-Beta protein, G-protein, G-alpha subunits, cancer, AKT pathway, signal transduction, protein interaction, oncogenesis GNB2, mutations, G-beta protein, cancers, GNB2 mutations, G-protein signaling, G-alpha subunits, AKT pathway, protein interaction, signal transduction, oncogenesis, cellular signaling GNB2, mutations, G-Beta protein, GBN2, cancer, G-alpha subunits, AKT pathway, signal transduction, protein interaction, oncogenesis, mutational impact, cellular signaling GNB2, mutations, G-Beta protein, G-protein, cancer, G-alpha subunits, AKT pathway, signal transduction, oncogenesis, protein interaction, cellular signaling
936	Peroxynitrite is required for nitration of TCR/CD8. Peroxynitrite, nitration, TCR, CD8, immune response, T cell, oxidative stress, signaling, Reactive nitrogen species, protein modification Peroxynitrite, nitration, T cell receptor, CD8, immune response, nitrating agents, reactive nitrogen species, T cell signaling, immune modulation, oxidative stress Peroxynitrite, nitration, T cell receptor, CD8, immune signaling, oxidative stress, protein modification, TCR nitration, immune response, reactive nitrogen species Peroxynitrite, nitration, TCR, CD8, immune response, T cell receptor, oxidative stress, reactive nitrogen species, cell signaling, post-translational modification Peroxynitrite, nitration, TCR, CD8, immune response, T cell receptor, oxidative stress, nitrating agents, immune signaling, reactive nitrogen species
36	A deficiency of vitamin B12 increases blood levels of homocysteine. Vitamin B12, homocysteine, deficiency, blood levels, methylation, anemia, neurological symptoms, hyperhomocysteinemia, cobalamin, metabolic pathway vitamin B12, deficiency, homocysteine, blood levels, increase, vitamin B12 deficiency, hyperhomocysteinemia, methylation, anemia, neurologic symptoms vitamin B12, deficiency, homocysteine, blood levels, increase, anemia, methylation, neurological health, deficiency symptoms, vitamin B12 deficiency, cardiovascular risk vitamin B12, deficiency, homocysteine, blood levels, causes, health effects, methylation, anemia, neurological symptoms vitamin B12, deficiency, blood homocysteine, elevated homocysteine, B12 deficiency, hyperhomocysteinemia, vitamin B12 impact, homocysteine metabolism, nutrient deficiency, cardiovascular risk
1132	TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells. TCR, CD3, microdomains, immunologic synapse, T cells, T cell activation, signal transduction, immune response, membrane microdomains, T cell receptor, immune synapse, cell signaling TCR, CD3, microdomains, immunologic synapse, T cell activation, immune signaling, receptor clustering, T cell receptor, signaling complexes, immune synapse formation TCR, CD3, microdomains, immunologic synapse, T cell activation, immune signaling, T cell receptor, cell membrane, signal transduction, immune response TCR, CD3, microdomains, immunologic synapse, T cell activation, signal transduction, immune response, T cell receptor, membrane microdomains, signal clustering TCR, CD3, microdomains, immunologic synapse, T cell activation, T cell signaling, immune response, T cell receptor, membrane microdomains, signal transduction
1130	T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation. T regulatory cells, Tregs, αvβ8, immune suppression, inflammation, pathogenic T-cells, immune regulation, T-cell responses, immune tolerance, immune modulation T regulatory cells, Tregs, αvβ8 integrin, immune regulation, T-cell suppression, inflammation, pathogenic T cells, immune response, immune tolerance, immune suppression T regulatory cells, Tregs, αvβ8, immune suppression, T-cell responses, inflammation, immune regulation, T cell suppression, pathogenic T cells, immune tolerance T regulatory cells, tTregs, αvβ8, immune suppression, pathogenic T-cell responses, active inflammation, T cell regulation, immune modulation, lymphocyte subsets, inflammation, immune tolerance T regulatory cells, tTregs, αvβ8, immune suppression, T-cell responses, inflammation, pathogenic T-cells, immune regulation, immune tolerance, T-cell regulation
380	Enhanced early production of inflammatory chemokines improves viral control in the lung. enhanced, early production, inflammatory, chemokines, viral control, lung early production, inflammatory chemokines, viral control, lung, immune response, chemokine expression, antiviral immunity, lung inflammation, immune regulation, viral clearance inflammatory chemokines, viral control, lung, early production, immune response, antiviral immunity, cytokine response, chemokine signaling, pulmonary immunity, immune modulation inflammatory chemokines, early production, viral control, lung, immune response, chemokine expression, antiviral immunity, lung inflammation, infection control, immune signaling inflammatory chemokines, early viral response, lung infection, immune control, chemokine production, viral clearance, immune response, pulmonary inflammation, antiviral immunity, cytokine expression
1370	Vitamin D deficiency is unrelated to birth weight. Vitamin D deficiency, birth weight, unrelated, maternal health, neonatal health, prenatal nutrition, vitamin D levels, fetal development, pregnancy outcomes, vitamin D deficiency effects Vitamin D, deficiency, unrelated, birth weight, maternal health, prenatal, fetal development, vitamin deficiency, pregnancy, neonatal, health, research Vitamin D deficiency, birth weight, unrelated, fetal development, maternal health, neonatal outcomes, vitamin D levels, prenatal nutrition, infant birth weight, epidemiology Vitamin D, deficiency, birth weight, unrelated, prenatal health, maternal nutrition, fetal development, neonatal outcomes, vitamin supplementation, pregnancy, epidemiology Vitamin D, deficiency, unrelated, birth weight, prenatal health, maternal nutrition, neonatal outcomes, pregnancy, fetal development, bone health, pediatric research
261	Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. chronic exercise, aerobic exercise, endothelial function, vasodilation, nitric oxide, NO, vascular health, blood vessel, cardiovascular, endothelial cells, exercise benefits, vascular function Chronic exercise, aerobic activity, endothelial function, vasodilation, nitric oxide, NO, vascular health, blood vessel, cardiovascular, arterial function, exercise adaptation, vascular biology chronic exercise, aerobic training, endothelial function, vasodilation, nitric oxide, NO, vascular health, cardiovascular adaptation, blood flow, endothelial cells chronic exercise, aerobic exercise, endothelial function, vasodilation, nitric oxide, NO, cardiovascular health, vascular biology, blood flow, endothelial cells Chronic exercise, aerobic training, endothelial function, vasodilation, nitric oxide, NO, cardiovascular health, vascular biology, blood flow, vascular tone
141	Auditory entrainment is strengthened when people see congruent visual and auditory information. auditory entrainment, visual-auditory integration, multisensory perception, cross-modal processing, sensory synchronization, audiovisual congruence, neural entrainment, perceptual binding, sensory integration, auditory-visual correlation auditory entrainment, visual-auditory integration, multisensory processing, sensory congruence, perceptual synchronization, cross-modal perception, auditory-visual coherence, sensory facilitation, multisensory enhancement, perceptual coupling auditory entrainment, visual-auditory integration, multisensory perception, sensory synchronization, crossmodal processing, congruent stimuli, audiovisual coherence, neural synchronization, sensory perception, perceptual binding auditory entrainment, visual-auditory integration, multisensory processing, congruent stimuli, sensory perception, audiovisual synchronization, perception enhancement, cognitive processing auditory entrainment, visual-auditory integration, multisensory processing, sensory perception, congruence, neural synchronization, cross-modal stimulation, perceptual coupling, sensory modalities, perceptual enhancement
142	Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immune suppression, infection risk, immunomodulation, stem cell therapy, transplantation outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, immune response, infection risk, stem cell therapy, immune modulation autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunotherapy, stem cell therapy, infection risk, immune suppression, graft versus host disease autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor, immunosuppression, infection risk, immune response, transplantation, immunotherapy autologous transplantation,mesenchymal stem cells,opportunistic infections,induction therapy,anti-interleukin-2 receptor antibodies,immune suppression,infection risk,stem cell therapy,immunomodulation,immune response
384	Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings. epidemiology, disease burden, noncommunicable diseases, prevalence, low-income, economic settings, public health, health disparities, morbidity, mortality epidemiology, disease burden, noncommunicable diseases, prevalence, low-income, economic settings, public health, chronic diseases, health disparities, socioeconomic factors epidemiology, disease burden, noncommunicable diseases, NCDs, prevalence, low socioeconomic settings, low income, health disparities, public health, chronic diseases, economic impact, health inequities epidemiology, disease burden, noncommunicable diseases, NCDs, low income, economic disparities, prevalence, public health, health inequalities, global health, socioeconomic factors, healthcare disparities Epidemiology, disease burden, noncommunicable diseases, prevalence, low-income settings, economic factors, health disparities, chronic diseases, public health, disease epidemiology, socioeconomic determinants
143	Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunotherapy, infection risk, stem cell therapy, immune modulation, transplantation outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immune modulation, stem cell therapy, infection risk, immunosuppression autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunomodulation, stem cell therapy, infection risk, immune suppression, transplantation outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor, infections, stem cell therapy, immunosuppression, cytokine therapy, transplantation outcomes autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor, immunosuppression, infection risk, stem cell therapy, immunomodulation, transplantation outcomes
385	Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. epigenetics, epigenetic therapy, immunomodulation, immune response, antitumor immunity, cancer model, EMA, epigenetic agents, tumor microenvironment, immune system, cancer immunotherapy, gene regulation, histone modification, DNA methylation, immune evasion Epigenetic, modulating agents, EMAs, antitumor, immune response, cancer, model system, epigenetics, immunotherapy, tumor microenvironment, immune modulation, histone modification, DNA methylation, gene expression, cancer immunology epigenetics, EMAs, antitumor immunity, immune response, cancer model, epigenetic therapy, immune modulation, tumor microenvironment, methylation, histone modification, gene expression, immunotherapy, immunomodulation epigenetics, epigenetic therapy, immune response, antitumor immunity, cancer models, modulating agents, immuno-oncology, tumor microenvironment, gene regulation, immune modulation, epigenetic drugs, cancer immunotherapy, histone modification, DNA methylation, immune system, cancer research Epigenetics, Modulating agents, EMAs, Antitumor immunity, Immune response, Cancer model, Epigenetic therapy, Tumor microenvironment, Immune modulation, Cancer immunotherapy
386	Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations. peripheral IV, drug administration, errors, bolus, medicine preparations, multiple-step, infusion, medication safety, patient safety, healthcare, intravenous, drug delivery peripheral IV, drug administration, bolus injection, medication errors, multi-step preparation, intravenous therapy, medication safety, infusion techniques, clinical errors, patient safety peripheral IV, drug administration, bolus injection, medication preparation, administration errors, multi-step processes, infusion therapy, medication safety, intravenous therapy, drug delivery, healthcare errors peripheral IV, drug administration, errors, bolus injection, medication preparation, healthcare safety, infusion techniques, nursing practice, medication errors, intravenous therapy peripheral IV, drug administration, bolus administration, medicine preparations, medication errors, infusion errors, intravenous therapy, patient safety, medication administration, healthcare errors, nursing practices
1368	Vitamin D deficiency effects the term of delivery. Vitamin D, deficiency, effects, term of delivery, pregnancy, prenatal, maternal health, obstetrics, neonatal outcomes, gestation, sunlight exposure, supplementation, fetal development, preterm birth Vitamin D, deficiency, effects, term of delivery, pregnancy, preterm birth, gestation, maternal health, neonatal outcomes, vitamin D levels, pregnancy complications Vitamin D, deficiency, pregnancy, term of delivery, preterm birth, maternal health, fetal development, insufficiency, obstetrics, neonatal outcomes Vitamin D, deficiency, pregnancy, gestation, effects, preterm, term delivery, fetal development, maternal health, obstetrics Vitamin D deficiency, pregnancy, term of delivery, preterm birth, gestation, maternal health, obstetrics, fetal development, sunlight, vitamin supplementation, pregnancy outcomes
146	Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. autologous, transplantation, mesenchymal, stem cells, rejection, induction therapy, anti-interleukin-2, receptor antibodies autologous transplantation, mesenchymal stem cells, rejection, induction therapy, anti-interleukin-2 receptor antibodies, immune tolerance, stem cell therapy, transplantation immunology, rejection rates, immunosuppression autologous transplantation, mesenchymal stem cells, rejection, induction therapy, anti-interleukin-2 receptor antibodies, immune tolerance, stem cell therapy, immunosuppression, transplant rejection, rejection rates autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immune tolerance, graft survival, immunosuppressive therapy, stem cell therapy, transplantation outcomes autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immune tolerance, stem cell therapy, immunosuppression, graft acceptance, transplant rejection
388	Ethanol stress decreases the expression of IBP in bacteria. Ethanol, stress, gene expression, IBP, bacteria, ethanol stress, bacterial response, protein expression, stress response, microbial adaptation Ethanol stress, IBP expression, bacteria, gene regulation, ethanol tolerance, microbial response, stress response, bacterial gene expression, ethanol adaptation, IBP function Ethanol, stress, gene expression, IBP, bacteria, bacterial response, alcohol stress, protein expression, gene regulation, microbial stress response Ethanol, stress, bacterial, IBP, gene expression, inhibition, quorum sensing, bacterial response, protein, stress response Ethanol stress, IBP, bacterial gene expression, stress response, microbial adaptation, ethanol tolerance, bacterial stress mechanisms, gene regulation, IBP expression, microbial physiology
268	Cold exposure increases BAT recruitment. cold exposure, brown adipose tissue, BAT, thermogenesis, fat oxidation, cold adaptation, adipose tissue recruitment, thermogenic response, cold acclimation, energy expenditure cold exposure, brown adipose tissue, BAT, thermogenesis, temperature, metabolic rate, cold adaptation, fat burning, heat production, non-shivering thermogenesis, adipose tissue, energy expenditure cold exposure, brown adipose tissue, BAT, thermogenesis, cold adaptation, adipose tissue, cold tolerance, energy expenditure, metabolic rate, fat burning, thermogenic response cold exposure, brown adipose tissue, BAT, thermogenesis, cold adaptation, adipose recruitment, temperature regulation, non-shivering thermogenesis, metabolic rate, fat burning cold exposure, brown adipose tissue, BAT, thermogenesis, cold therapy, temperature, metabolic rate, adipose tissue, energy expenditure, cold tolerance, heat production
1245	The one-child policy has been successful in lowering population growth. one-child policy, population control, population growth, demographic policy, fertility rate, China, family planning, population decline, policy effectiveness, birth rate reduction one-child policy, population control, birth rate reduction, demographic impact, policy effectiveness, fertility decline, population management, China's population policy one-child policy, population control, demographic changes, birth rate, family planning, China's population policy, population growth reduction, reproductive rights, policy effectiveness, population management one-child policy, population control, demographic change, birth rate reduction, family planning, government policy, population management one-child policy, population control, demographic impact, fertility rates, population growth, family planning, Chinese policy, birth rates, government regulation, demographic trends
148	Autophagy declines in aged organisms. autophagy, aging, age-related decline, cellular degradation, lysosomal function, age, cellular maintenance, lifespan, senescence, metabolic processes, proteostasis, age-associated diseases Autophagy, aging, aged organisms, decline, cellular degradation, longevity, age-related decline, autophagic activity, cellular homeostasis, lifespan, senescence, proteostasis Autophagy, aging, aging organisms, cellular degradation, age-related decline, cellular homeostasis, lysosomal function, protein degradation, cellular aging, age-associated deterioration Autophagy, aging, decline, aged organisms, cellular degradation, longevity, age-related diseases, autophagic mechanisms, cellular homeostasis, age-associated decline Autophagy, aging, decline, aged organisms, cellular degradation, lifespan, age-related decline, autophagy pathways, cellular maintenance, longevity, age-associated dysfunction
269	Cold exposure reduces BAT recruitment. cold exposure, brown adipose tissue, BAT, recruitment, thermogenesis, cold environment, temperature, fat metabolism, brown fat activation, adaptive thermogenesis, cold tolerance cold exposure, brown adipose tissue, BAT recruitment, thermogenesis, cold tolerance, adipose tissue, thermogenic activation, metabolic rate, cold acclimation, norepinephrine, UCP1, heat production, energy expenditure cold exposure, brown adipose tissue, BAT, recruitment, thermogenesis, cold tolerance, adaptive thermogenesis, cold acclimation, adipose tissue, metabolic adaptation cold exposure, brown adipose tissue, BAT, recruitment, thermogenesis, cold adaptation, metabolic rate, fat metabolism, heat production, adipose tissue, thermogenic response cold exposure, brown adipose tissue, BAT recruitment, thermogenesis, cold stress, adipose tissue, metabolic adaptation, heat production, energy expenditure, cold acclimation
820	N-terminal cleavage increases success identifying transcription start sites. N-terminal cleavage, transcription start sites, TSS identification, protein processing, gene regulation, transcription initiation, cleavage enzymes, promoter regions, molecular biology, gene expression N-terminal cleavage, transcription start sites, TSS, gene expression, protein processing, post-translational modification, proteolysis, transcription regulation, protein cleavage, molecular biology N-terminal cleavage, transcription start sites, TSS, gene regulation, protein processing, molecular biology, transcription initiation, experimental methods, TSS mapping, proteolytic processing N-terminal, cleavage, transcription, start sites, TSS, RNA processing, promoter, gene expression, protein cleavage, transcription initiation, molecular biology N-terminal cleavage, transcription start sites, TSS, gene expression, protein processing, cleavage sites, transcription initiation, molecular biology, gene regulation, proteolytic processing
700	Localization of PIN1 in the Arabidopsis embryo does not require VPS9a PIN1, Arabidopsis, embryo, localization, VPS9a, protein trafficking, auxin transport, cellular polarity, plant development, endocytosis PIN1, localization, Arabidopsis embryo, VPS9a, protein trafficking, endocytosis, cell polarity, auxin transport, plant development, vesicle trafficking PIN1, Arabidopsis, embryo, localization, VPS9a, plant development, auxin transport, cellular localization, protein function, gene expression PIN1, Arabidopsis, embryo, localization, VPS9a, gene expression, plant development, vesicle trafficking, auxin transport, cellular polarity PIN1, Arabidopsis, embryo, localization, VPS9a, plant development, cell polarity, protein trafficking, endocytosis, auxin transport, gene expression, molecular biology, plant genetics
821	N-terminal cleavage reduces success identifying transcription start sites. N-terminal cleavage, transcription start sites, TSS, gene regulation, promoter analysis, protein processing, transcription initiation, molecular biology, gene expression, experimental techniques N-terminal cleavage, transcription start sites, TSS identification, gene regulation, protein processing, transcription initiation, cleavage effects, promoter analysis, gene expression, biomolecular mechanisms N-terminal cleavage, transcription start sites, TSS, gene regulation, protein processing, transcription initiation, proteolytic cleavage, promoter identification, RNA sequencing, bioinformatics, genome annotation N-terminal cleavage, transcription start sites, TSS, gene expression, promoter regions, proteolytic processing, transcription regulation, RNA sequencing, genome annotation, protein processing N-terminal cleavage, transcription start sites, TSS, RNA sequencing, gene expression, promoter regions, transcription regulation, cleavage impact, start site identification, molecular biology
702	Localization of PIN1 in the roots of Arabidopsis does not require VPS9a PIN1, Arabidopsis, roots, localization, VPS9a, gene expression, plant biology, auxin transport, protein targeting, root development PIN1, localization, Arabidopsis, roots, VPS9a, protein trafficking, auxin transport, endocytosis, vesicle-mediated transport, gene expression, plant development PIN1, localization, Arabidopsis, roots, VPS9a, plant hormones, auxin transport, protein trafficking, endocytosis, gene expression, root development, cellular localization, plant molecular biology PIN1, Arabidopsis, root, localization, VPS9a, plant biology, protein trafficking, cell polarity, auxin transport, molecular biology PIN1, localization, Arabidopsis, roots, VPS9a, plant biology, auxin transport, protein trafficking, gene expression, root development
823	N348I mutations cause resistance to zidovudine (AZT). N348I, mutations, resistance, zidovudine, AZT, HIV, reverse transcriptase, drug resistance, antiviral, mutation effects N348I, mutations, resistance, zidovudine, AZT N348I, mutations, resistance, zidovudine, AZT, HIV, reverse transcriptase, antiviral resistance, drug resistance mutations, HIV drug resistance N348I, mutations, resistance, zidovudine, AZT, HIV, reverse transcriptase, drug resistance, antiretroviral, viral mutation N348I, mutations, resistance, zidovudine, AZT, HIV, reverse transcriptase, drug resistance, antiviral, mutation effects
42	A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. microerythrocyte, microcytosis, anemia, homozygous alpha thalassemia, alpha (+) thalassemia, red blood cell count, hemoglobin, hematology, blood disorders, genetic traits, erythrocyte morphology microerythrocyte, microcytosis, anemia, alpha-thalassemia, homozygous, genetic traits, red blood cell count, hemoglobin, hematology, iron deficiency, erythropoiesis, blood disorders, hematological abnormalities microerythrocyte, hematology, anemia, alpha-thalassemia, homozygous, red blood cells, erythrocyte count, blood disorders, hemoglobinopathy, genetic traits microerythrocyte, microcytosis, anemia, alpha-thalassemia, homozygous, genetic traits, hematology, red blood cells, hemoglobin, hemoglobinopathies, erythrocyte count, blood disorder, genetic predisposition microerythrocyte, microcytosis, anemia, homozygous alpha-thalassemia, thalassemia trait, erythrocyte count, red blood cells, hemoglobin, hematology, blood disorder, genetic mutation, hematocrit
48	A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. asymptomatic carriers, vCJD, UK, prion disease, infection prevalence, public health, neurodegenerative, transmission, epidemiology, disease surveillance UK, asymptomatic carriers, vCJD, infection, total, 1,000 people vCJD, asymptomatic carriers, UK, prion disease, infection prevalence, neurological disorder, public health, disease transmission, epidemiology, variant Creutzfeldt-Jakob disease asymptomatic carriers, vCJD, UK, prion disease, infection prevalence, epidemiology, neurodegenerative disease, public health, disease transmission, case study, neurological disorder asymptomatic, carriers, vCJD, infection, UK, population, prevalence, prion disease, public health, epidemiology
49	ADAR1 binds to Dicer to cleave pre-miRNA. ADAR1, Dicer, pre-miRNA, RNA editing, microRNA processing, enzyme interaction, RNA cleavage, gene regulation, post-transcriptional modification ADAR1, Dicer, pre-miRNA, RNA editing, microRNA processing, enzyme interaction, gene regulation, RNA cleavage, double-stranded RNA, post-transcriptional modification ADAR1, Dicer, pre-miRNA, cleavage, RNA editing, microRNA biogenesis, RNA interference, dsRNA, molecular interaction, enzyme, post-transcriptional regulation ADAR1, Dicer, pre-miRNA, RNA editing, microRNA processing, RNA interference, enzymatic activity, gene regulation, double-stranded RNA, post-transcriptional modification ADAR1,Dicer,pre-miRNA,binds,RNA editing,protein interaction,microRNA processing,enzyme function,RNA cleavage,dsRNA
1385	cSMAC formation enhances weak ligand signalling. cSMAC, T cell activation, immunological synapse, ligand signaling, signal strength, immune response, T cell receptor, synapse formation, cytokine signaling, immune modulation cSMAC, T cell signaling, immunological synapse, ligand engagement, signal strength, immune response, T cell activation, immunological synapse formation, TCR clustering, cell communication cSMAC, T cell, immune synapse, ligand signaling, T cell activation, immunological synapse, Signal transduction, costimulation, T cell receptor, immune response, cell signaling, antigen presentation cSMAC, T cell activation, immune synapse, ligand signaling, signal transduction, immune response, T cell receptor, immunology, cell signaling, antigen presentation cSMAC, T cell receptor, immune synapse, ligand signaling, signal transduction, immunological synapse, T cell activation, molecular clustering, cell communication, immune response
1021	Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus. interferon-induced genes, West Nile virus, neuronal survival, granule cells, viral infection, gene regulation, immune response, neuroinflammation, antiviral response, gene expression, neuronal infection, innate immunity interferon-induced genes, rapid up-regulation, basal expression, granule cell neurons, West Nile virus, viral infection, neuronal survival, immune response, gene expression, neurovirology interferon-induced genes, up-regulation, basal expression, West Nile virus, granule cell neurons, infection, survival, immune response, neuroinflammation, antiviral response interferon-induced genes, West Nile virus, granule cell neurons, neuronal survival, viral infection, up-regulation, gene expression, innate immunity, neurotropism, antiviral response interferon, gene expression, West Nile virus, neuron survival, granule cells, up-regulation, basal expression, antiviral response, neuroinflammation, West Nile virus pathogenesis
1020	Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus. interferon-induced genes, West Nile virus, granule cell neurons, viral infection, gene regulation, immune response, neural survival, up-regulation, basal expression, antiviral response interferon-induced genes, up-regulation, basal expression, West Nile virus, granule cell neurons, viral infection, immune response, neuronal survival, gene expression, neurotropism interferon-induced genes, gene expression, West Nile virus, neuron survival, granule cells, viral infection, immune response, up-regulation, basal expression, neuroprotection interferon-induced genes, basal expression, up-regulation, West Nile virus, granule cell neurons, infection, survival, immune response, neuronal infection, gene expression, neurotropic virus interferon, gene expression, up-regulation, basal expression, West Nile virus, neuron survival, granule cells, antiviral response, infection, immune response
1262	The repair of Cas9-induced double strand breaks in human DNA is error-prone. CRISPR, Cas9, double-strand breaks, DNA repair, error-prone, genome editing, repair mechanisms, homologous recombination, non-homologous end joining, DNA damage, human genome Cas9, double strand breaks, human DNA, DNA repair, error-prone, genome editing, CRISPR, DNA damage repair, non-homologous end joining, homologous recombination Cas9, double strand breaks, DNA repair, error-prone, human DNA, genome editing, CRISPR, non-homologous end joining, homologous recombination, DNA damage, repair mechanisms Cas9, double strand breaks, DNA repair, error-prone, human genome, genome editing, CRISPR, homologous recombination, non-homologous end joining, genomic instability Cas9, double strand breaks, DNA repair, human DNA, error-prone, genome editing, non-homologous end joining, homologous recombination, DNA damage response, CRISPR, genetic editing, repair fidelity
1140	Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer. α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, supplement, prostate health, antioxidant, cancer risk, male health α-tocopheryl acetate, 400mg, prostate cancer, prevention, vitamin E, antioxidants, prostate health, supplement, cancer risk, male health α-tocopheryl acetate, vitamin E, prostate cancer, cancer prevention, antioxidant, 400mg, supplement, prostate health, tocopherol, dietary supplement α-tocopheryl acetate, vitamin E, prostate cancer, prevention, dosage, cancer risk, supplementation, prostate health, antioxidant, 400mg α-tocopheryl acetate, vitamin E, prostate cancer, prevention, 400mg, supplement, health benefits, antioxidant, prostate health, cancer risk
1382	aPKCz causes tumour enhancement by affecting glutamine metabolism. aPKCz, tumour, cancer, glutamine metabolism, metabolic pathways, oncogenesis, signal transduction, enzyme activity, cellular metabolism, tumor progression aPKCz, tumor growth, glutamine metabolism, cancer progression, metabolic pathways, oncogenes, tumor microenvironment, cellular metabolism, biochemical pathways, amino acid metabolism aPKCz, tumour enhancement, glutamine metabolism, cancer metabolism, kinase, tumor growth, metabolic regulation, oncogenesis, cell signaling, glutamine utilization, tumor progression, enzymatic activity aPKCz, tumour, enhancement, glutamine metabolism, cancer metabolism, kinase, signaling pathway, tumor progression, metabolic regulation, oncogenesis aPKCz, tumour enhancement, glutamine metabolism, cancer metabolism, PKC zeta, tumor progression, metabolic pathways, oncogenesis, glutamine utilization, signal transduction
274	Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy. nicotine replacement therapy, combination therapy, varenicline, bupropion, smoking cessation, abstinence rates, long-term abstinence, 52 weeks, monotherapy, treatment comparison nicotine replacement therapy, combination therapy, varenicline, bupropion, smoking cessation, abstinence rates, long-term, 52 weeks, monotherapy, efficacy, treatment outcomes nicotine replacement therapy, combination therapy, varenicline, bupropion, smoking cessation, abstinence rate, long-term abstinence, 52 weeks, monotherapy, treatment efficacy nicotine replacement therapies, combination therapy, varenicline, bupropion, long-term abstinence, smoking cessation, 52 weeks, monotherapy, treatment efficacy smoking cessation, nicotine replacement therapy, NRT, varenicline, bupropion, combination therapy, monotherapy, abstinence rates, long-term, 52 weeks, quit smoking
1019	Rapid phosphotransfer rates govern fidelity in two component systems phosphotransfer, rates, fidelity, two-component systems, signal transduction, kinase activity, response regulators, phosphorylation, biological signaling, molecular mechanisms phosphotransfer, rates, fidelity, two-component systems, signal transduction, phosphorylation, response regulators, sensor kinases, kinetics, molecular mechanisms phosphotransfer, rates, fidelity, two-component systems, signal transduction, protein phosphorylation, transfer kinetics, molecular signaling, bacterial signaling, enzyme specificity phosphotransfer, rates, fidelity, two-component systems, signal transduction, histidine kinase, response regulator, protein phosphorylation, enzymatic kinetics, cellular communication phosphotransfer, two-component systems, signal transduction, kinase, phosphorelay, protein phosphorylation, bacterial signaling, enzymatic rates, molecular specificity, cellular communication
275	Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. phosphatidylinositide 3-kinase, PI3K, MEK 1/2, inhibitors, combination therapy, KRAS mutant, tumor treatment, targeted therapy, signal transduction, cancer, oncology phosphatidylinositide 3-kinase, PI3K, MEK 1/2, inhibitors, combination therapy, KRAS mutant, tumor treatment, targeted therapy, cancer, signaling pathways phosphatidylinositide 3-kinase, PI3K, MEK 1/2, inhibitors, combination therapy, KRAS mutant tumors, targeted therapy, cancer treatment, signal transduction, kinase inhibitors phosphatidylinositide 3-kinase, PI3K, MEK inhibitors, KRAS mutant tumors, targeted therapy, cancer treatment, combination therapy, kinase inhibition, tumor suppression, oncogene, signaling pathway phosphatidylinositide 3-kinase, PI3K, MEK 1/2, kinase inhibitors, KRAS mutant tumors, targeted therapy, cancer treatment, combination therapy, oncogenic pathways, tumor suppression
1259	The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up. breast cancer, tamoxifen, metabolism, treatment outcome, genetic make-up, pharmacogenomics, drug metabolism, patient genetics, personalized medicine, hormone receptor, CYP2D6, treatment response, gene variants, pharmacokinetics breast cancer, tamoxifen metabolism, treatment outcome, genetic makeup, pharmacogenomics, drug response, personalized medicine, genetic factors, CYP2D6, therapeutic efficacy, hormone receptor, estrogen receptor, cancer genetics, patient genetics breast cancer, tamoxifen, metabolism, treatment outcome, genetics, pharmacogenetics, drug metabolism, personalized medicine, genetic variation, CYP2D6, treatment response breast cancer, tamoxifen, metabolism, treatment outcome, genetic make-up, pharmacogenomics, drug metabolism, personalized medicine, genetic variability, therapy response breast cancer, tamoxifen, metabolism, genetic make-up, treatment outcome, pharmacogenomics, drug response, genetic factors, personalized medicine, hormone receptor, CYP2D6, drug metabolism, efficacy, genetic polymorphism
1137	TNFAIP3 is a tumor suppressor in glioblastoma. TNFAIP3, tumor suppressor, glioblastoma, glioma, cancer, gene regulation, apoptosis, tumorogenesis, inflammatory response, NF-kB pathway TNFAIP3, tumor suppressor, glioblastoma, glioma, gene expression, cancer biology, neuro-oncology, tumor suppressor genes, molecular genetics, brain tumors TNFAIP3, tumor suppressor, glioblastoma, glioma, brain cancer, NF-kB signaling, gene expression, molecular biology, cancer genetics, tumor suppression, glioblastoma research TNFAIP3, tumor suppressor, glioblastoma, glioma, NF-kB pathway, gene regulation, cancer biology, tumorigenesis, molecular oncology, brain tumors TNFAIP3, tumor suppressor, glioblastoma, glioma, NF-kB pathway, gene expression, cancer biology, tumorigenesis, molecular genetics, oncogene, tumor suppressor gene
1379	Women with a higher birth weight are more likely to develop breast cancer later in life. women, higher birth weight, breast cancer, epidemiology, risk factors, maternal health, fetal development, hormonal influences, early life factors, cancer risk, pregnancy outcomes, longitudinal studies women, higher birth weight, breast cancer, risk factors, prenatal factors, maternal health, fetal development, epidemiology, long-term health outcomes, gender, hormonal influence, early life, disease correlation women, birth weight, breast cancer, risk factors, later life, higher birth weight, epidemiology, maternal health, fetal development, cancer risk women, higher birth weight, breast cancer, risk factors, early life, prenatal, maternal health, epidemiology, long-term health, developmental origins, cancer risk, women's health women, birth weight, higher birth weight, breast cancer, later in life, risk factors, maternal health, fetal development, long-term health, epidemiology
399	Exposure to fine particulate air pollution is relate to anxiety prevalence. air pollution, fine particles, PM2.5, anxiety, mental health, health effects, respiratory health, behavioral impact, environmental exposure, epidemiology, pollution-related anxiety air pollution, fine particulates, PM2.5, air quality, mental health, anxiety, prevalence, health effects, environmental health, respiratory health, neuropsychological impact, pollution exposure, public health, air quality standards fine particulate matter, air pollution, anxiety, mental health, pollution exposure, public health, cardiovascular health, neuroinflammation, oxidative stress, environmental health air pollution, fine particles, particulate matter, exposure, anxiety, mental health, air quality, health effects, pollution, environmental health fine particulate matter, air pollution, anxiety, mental health, exposure, prevalence, respiratory health, cognitive effects, environmental health, public health, pollution sources, health outcomes
279	Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs. Commelina, yellow mottle virus, ComYMV, genome, genome length, base pairs, viral genome, plant virus, molecular biology, viral genetics Commelina, yellow mottle virus, ComYMV, genome, genome sequence, viral genome, plant viruses, baise pairs, DNA, RNA, virus genetics, molecular biology Commelina yellow mottle virus, ComYMV, genome, genome sequence, base pairs, 7489, virus genomics, plant virus, viral genome, molecular biology, plant pathology Commelina, yellow mottle virus, ComYMV, genome, genome sequence, base pairs, viral genome, plant virus, genome length, molecular biology, virology Commelina, yellow mottle virus, ComYMV, genome, genetic sequence, base pairs, 7489, viral DNA, plant virus, genome structure, viral genome, DNA sequence
1014	Rapamycin decreases the concentration of triacylglycerols in fruit flies. Rapamycin, triacylglycerols, triglycerides, fruit flies, Drosophila, lipid metabolism, fat reduction, mTOR pathway, aging, metabolic regulation, lipid storage Rapamycin, triacylglycerols, fruit flies, Drosophila, lipid metabolism, lipid reduction, autophagy, mTOR pathway, aging, fat accumulation, nutritional regulation, pharmacology Rapamycin, triacylglycerols, triglycerides, Drosophila, fruit flies, lipid metabolism, fat regulation, mTOR, aging, obesity, lipid storage, pharmacology Rapamycin, triacylglycerols, triacylglyceride, fruit flies, Drosophila, lipid metabolism, fat storage, TOR pathway, mTOR, lipid regulation, lipid biosynthesis, aging, metabolic health Rapamycin, triacylglycerols, triglycerides, fruit flies, Drosophila, lipid metabolism, lipid levels, pharmacology, aging, nutrient sensing, TOR pathway, fat storage, metabolism, pharmacological intervention
830	NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases. NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, activation, LATS1/2, kinases, tumor suppressor, Hippo pathway, cell signaling, gene regulation NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1/2 kinases, kinase activation, Hippo pathway, tumor suppressor, cell signaling, protein localization, gene regulation NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, LATS1/2 kinases, tumor suppressor, Hippo pathway, kinase activation NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, LATS1/2 kinases, kinase activation, tumor suppressor, Hippo pathway NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway, tumor suppressor, cell signaling, protein interactions
831	NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila. NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, tumor suppressor, Hippo pathway, cell signaling, protein interaction, gene regulation NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell signaling, protein regulation NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, tumor suppressor, Hippo pathway, cell signaling, protein regulation NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell signaling, protein interactions NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, tumor suppressor, Hippo pathway, cell signaling, protein regulation
1012	Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume. radioiodine, treatment, non-toxic, multinodular goitre, thyroid volume, reduction, therapy, hyperthyroidism, thyroid nodules, iodine therapy Radioiodine, treatment, non-toxic multinodular goitre, thyroid volume, reduction, hyperthyroidism, thyroid nodule, iodine therapy, thyroid disease, multinodular goiter, radioisotope therapy radioiodine, treatment, non-toxic, multinodular goitre, thyroid volume, reduction, therapy, benign, hyperplasia, iodine therapy, thyroid nodules, gland size radioiodine, radioiodine therapy, non-toxic multinodular goitre, thyroid volume, thyroid treatment, goitre management, thyroid nodules, radioactive iodine, thyroid reduction, gland size, hyperthyroidism treatment Radioiodine, treatment, non-toxic multinodular goitre, thyroid volume, reduction, hyperthyroidism, benign goitre, radioiodine therapy, thyroid nodules, thyroid gland, volume decrease, thyroid disease
832	NFAT4 activation requires IP3R-mediated Ca2+ mobilization. NFAT4, activation, IP3R, inositol trisphosphate receptor, Ca2+ mobilization, calcium signaling, transcription factors, calcium release, signal transduction, cellular signaling NFAT4, activation, IP3R, inositol trisphosphate receptor, Ca2+ mobilization, calcium signaling, transcription factor, calcium release, immune response, signaling pathway NFAT4, activation, IP3R, inositol trisphosphate receptor, Ca2+ mobilization, calcium signaling, transcription factors, calcium release, signal transduction, cellular signaling NFAT4, activation, IP3R, inositol trisphosphate receptor, Ca2+ mobilization, calcium signaling, cellular signaling, transcription factors, calcium release, signaling pathways NFAT4, activation, IP3R, inositol trisphosphate receptor, Ca2+ mobilization, calcium signaling, cellular signaling, transcription factors, calcium release, signal transduction
834	NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates. NOX2, peroxynitrite, nitrogen intermediates, reactive nitrogen species, NOX2-independent pathways, reactive oxygen species, nitrosative stress, NADPH oxidase, nitric oxide, reactive intermediates, biochemical pathways NOX2, pathways, peroxynitrite, nitrogen intermediates, reactive nitrogen species, oxidative stress, reactive oxygen species, nitrosative stress, enzymatic reactions, free radicals NOX2, pathways, peroxynitrite, nitrogen intermediates, reactive nitrogen species, oxidative stress, enzyme-independent, reactive oxygen species, nitric oxide, reactive nitrogen, free radicals NOX2, peroxynitrite, pathways, nitrogen intermediates, reactive species, oxidative stress, reactive nitrogen species, peroxynitrite formation, nitric oxide, oxidative pathways, enzyme-independent mechanisms NOX2, pathways, peroxynitrite, nitrogen intermediates, reactive nitrogen species, oxidative stress, immune response, reactive oxygen species, nitric oxide, signaling mechanisms
956	Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling. GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, receptor signaling, GPCR, signal transduction, pharmacology, endocrinology, ligand-receptor interaction Pleiotropic, coupling, GLP-1R, intracellular, effectors, cellular signaling, receptor signaling, G protein-coupled receptors, signaling pathways, effector proteins, receptor pharmacology, cellular response GLP-1R, pleiotropy, intracellular signaling, effectors, coupling, cellular response, receptor signaling pathways, molecular mechanisms, GPCR, signal transduction GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, signal transduction, receptor pharmacology, GPCR, receptor signaling pathways, pathway specificity, effector proteins, receptor-ligand interactions Pleiotropic coupling, GLP-1R, intracellular effectors, cellular signaling, receptor signaling, G-protein coupled receptors, GLP-1, signal transduction, effector pathways, receptor-effector coupling, cellular response, signaling profiles
50	AIRE is expressed in some skin tumors. AIRE, gene expression, skin tumors, dermatological neoplasms, immune regulation, autoimmune disease, thymic transcription factor, tumor biology, oncogenesis, immune tolerance AIRE, expressed, skin tumors, skin cancer, autoimmunity, thymus, immune regulation, tumor immunology, gene expression, skin neoplasms, immune tolerance AIRE, expression, skin tumors, skin cancer, autoimmunity, thymic gene, immune tolerance, tumor immunology AIRE, immune tolerance, skin tumors, thymic regulator, autoimmune regulator, tumor immunology, skin cancer, gene expression, tumor microenvironment, immune response AIRE, expressed, skin tumors, skin cancer, autoimmune regulator, thymic epithelial cells, tumor biomarkers, skin neoplasms, immune regulation, gene expression, tumor pathology
715	Low expression of miR7a does represses target genes and exerts a biological function in ovaries. miR7a, microRNA, gene regulation, ovarian function, target genes, gene repression, reproductive biology, ovarian biology, miRNA expression, cellular regulation miR-7a, gene repression, ovarian function, microRNA, gene expression, target genes, reproductive biology, ovarian regulation, miRNA, molecular biology miR7a, microRNA, gene regulation, ovarian function, target genes, gene repression, biological role, expression levels, reproductive biology, ovarian tissue miR7a, gene regulation, ovarian function, microRNA, target gene repression, reproductive biology, gene expression, ovarian biology, miRNA function, biological processes miR7a, microRNA, gene regulation, ovaries, gene expression, repression, biological function, target genes, reproductive biology, RNA interference
957	Podocytes are motile and migrate in the presence of injury. Podocytes, motility, migration, injury, renal cells, glomerular cells, kidney injury, cell motility, cytoskeleton, cell migration Podocytes, motility, migration, injury, kidney, glomerulus, podocyte injury, cellular movement, renal cells, glomerular damage podocytes, motility, migration, injury, kidney, glomerulus, podocyte injury, cellular movement, renal, glomerular filtration podocytes, motility, migration, injury, glomerular filtration, renal cells, kidney injury, cell migration, podocyte injury, renal pathology Podocytes, motility, migration, injury, kidney, glomerulus, renal cells, damage, cellular response, cytoskeleton
51	ALDH1 expression is associated with better breast cancer outcomes. ALDH1, breast cancer, biomarkers, prognosis, cancer outcomes, stem cells, tumor markers, survival rates, cancer research, molecular markers ALDH1, breast cancer, prognosis, biomarkers, cancer outcomes, tumor markers, stem cells, cancer prognosis, ALDH1 expression, breast tumor biology ALDH1, expression, breast cancer, prognosis, biomarkers, outcomes, cancer stem cells, tumor aggressiveness, patient survival, chemical markers ALDH1, breast cancer, prognosis, biomarker, cancer outcomes, tumor markers, cancer stem cells, predictive biomarker, cancer prognosis, breast tumor, ALDH1 expression ALDH1, breast cancer, prognosis, biomarker, cancer outcomes, stem cells, tumor aggressiveness, cancer subtypes, survival rate, cancer research
716	Low expression of miR7a exerts a biological function in testis. miR7a, gene expression, testis, reproductive biology, microRNA, spermatogenesis, male fertility, gene regulation, testicular function, molecular biology miR7a, gene expression, testis, reproductive biology, microRNA, testicular function, molecular biology, RNA regulation, germ cells, spermatogenesis miR7a, microRNA, gene expression, testis, reproductive biology, spermatogenesis, fertility, molecular biology, gene regulation, testes, miRNA function miR7a, gene expression, testis, biological function, microRNA, reproductive biology, spermatogenesis, gene regulation, testicular tissue, molecular biology miR7a, gene expression, testis, biological function, microRNA, reproductive biology, male gonads, gene regulation, miRNA function, testicular function
837	NR5A2 is important in development of endometrial tissues. NR5A2, nuclear receptor, endometrial development, tissue development, gene expression, hormonal regulation, reproductive biology, uterine tissue, endometrial function, gene regulation NR5A2, nuclear receptor, gene expression, endometrial tissue, development, uterine biology, hormone regulation, reproductive health, gene function, endometrial differentiation NR5A2, nuclear receptor, endometrial tissue, development, gene expression, reproductive biology, uterus, estrogen signaling, tissue differentiation, molecular biology NR5A2, endometrial development, gene expression, reproductive biology, uterine tissue, hormone regulation, transcription factors, female fertility, endometrial regeneration, uterine tissue development NR5A2, nuclear receptor, gene expression, endometrial development, uterine tissue, reproductive biology, hormone regulation, transcription factors, endometrial tissue, tissue differentiation, reproductive system, molecular biology
53	ALDH1 expression is associated with poorer prognosis in breast cancer. ALDH1, expression, prognosis, breast cancer, biomarker, cancer progression, survival rate, tumor aggressiveness, cancer stem cells, prognosis factors ALDH1, expression, breast cancer, prognosis, biomarker, tumor aggressiveness, cancer stem cells, survival rate, poor prognosis, cancer progression ALDH1, breast cancer, prognosis, biomarker, cancer stem cells, tumor aggressiveness, disease outcome, survival rate, cancer prognosis, expression levels ALDH1, expression, poorer prognosis, breast cancer, biomarker, cancer outcome, prognosis, survival rate, cancer progression, stem cells, tumor marker ALDH1, expression, prognosis, breast cancer, biomarker, cancer prognosis, stem cells, tumor aggressiveness, survival rate, cancer markers
718	Low nucleosome occupancy correlates with low methylation levels across species. nucleosome occupancy, DNA methylation, epigenetics, chromatin structure, gene regulation, cross-species comparison, epigenetic modifications, chromatin accessibility, methylation levels, nucleosome positioning nucleosome occupancy, DNA methylation, epigenetic regulation, chromatin structure, species comparison, gene expression, epigenetic marks, genome accessibility, histone modifications, genomic stability nucleosome occupancy, methylation levels, epigenetics, chromatin structure, DNA methylation, cross-species comparison, gene regulation, epigenomic correlation, chromatin accessibility, genomic methylation nucleosome occupancy, DNA methylation, epigenetics, chromatin structure, species comparison, gene regulation, epigenomic correlation, chromatin accessibility, methylation levels, cross-species analysis nucleosome occupancy, DNA methylation, epigenetics, chromatin structure, cross-species comparison, epigenetic regulation, genome-wide analysis, chromatin accessibility, methylation patterns, nucleosome positioning
839	Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles. Nanoparticles, targeted delivery, cell-specific, aptamers, lipid nanoparticles, molecular targeting, drug delivery, nanotechnology, biomedical, therapeutic, precision medicine Nanoparticles, targeted delivery, cell specificity, aptamers, lipid nanoparticles, drug delivery, nanotechnology, molecular targeting, biomedical engineering, therapeutics nanoparticles, targeted delivery, cell-specific, aptamers, lipid nanoparticles, ligand modification, drug delivery, precision medicine, nanocarriers, bioconjugation Nanoparticles, targeted delivery, aptamers, lipid nanoparticles, cell-specific, drug delivery, nanomedicine, nanocarriers, targeting ligands, particle surface functionalization Nanoparticles, targeted delivery, cell specificity, aptamers, lipid nanoparticles, nanotechnology, drug delivery, precision medicine, cellular targeting, nanoparticle functionalization
54	AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. AMPK, activation, inflammation, fibrosis, lungs, lung, pulmonary, immune response, chronic inflammation, tissue remodeling, signaling pathways, metabolic regulation, exercise, pharmacology, therapeutics, inflammatory cytokines, fibrotic markers AMPK,activation,protein kinase,inflammation,fibrosis,lungs,lung tissue,cell signaling,metabolic regulation,inflammatory response,fibrotic pathways,respiratory diseases,lung fibrosis,molecular mechanisms,cell metabolism,pathogenesis AMPK, activation, inflammation, fibrosis, lungs, pulmonary, kinase, signaling pathways, cytokines, oxidative stress, tissue remodeling, chronic lung disease, immune response AMPK, activation, inflammation, fibrosis, lungs, pulmonary, cytokines, signaling pathways, cellular stress, metabolic regulation, chronic lung disease, tissue remodeling, inflammation markers, molecular mechanisms AMPK, activation, inflammation, fibrosis, lungs, pulmonary, immune response, signaling pathway, metabolic regulation, lung disease, tissue remodeling
56	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. APOE4, iPSC, neurons, AlphaBeta, tau phosphorylation, GABA neurons, neurodegeneration, neurodegenerative diseases, Alzheimer’s disease, amyloid beta, tau protein, neuronal degeneration, gene expression, neurobiology APOE4, iPSC-derived neurons, AlphaBeta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau protein, neuron death, neuroinflammation, genetic factors, neurodegenerative cascade APOE4, iPSC-derived neurons, alpha-beta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid-beta, tau pathology, neuronal degeneration, neurobiology, gene expression, neurodegenerative mechanisms APOE4, iPSC-derived neurons, AlphaBeta, amyloid, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, neuronal pathology, genetic risk factors, neurodegenerative mechanisms APOE4, iPSC-derived neurons, AlphaBeta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid-beta, tau proteins, neuron degeneration, genetic factors, neurobiology, neurodegenerative mechanisms
57	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau protein, neuronal differentiation, neurodegenerative biomarkers APOE4, iPSC, neurons, AlphaBeta, tau phosphorylation, GABA neuron, degeneration, neurodegeneration, Alzheimer’s, amyloid, tau protein, neurotransmitter, neurodegenerative disease APOE4, iPSC-derived neurons, AlphaBeta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, amyloid beta, Alzheimer’s disease, genetic expression, neuron pathology, neurobiology APOE4, iPSC-derived neurons, AlphaBeta, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau proteins, neuronal degeneration, genetic risk factors, neurobiology, neuron models APOE4, iPSC neurons, AlphaBeta, tau phosphorylation, GABA neurons, neurodegeneration, Alzheimer’s disease, amyloid beta, neurodegenerative pathways, neuronal aging, genetic factors, neuroinflammation
1274	The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins. type VI secretion system, T6SS, inner tube tip, antibacterial effector, Escherichia coli, E. coli, toxic proteins, secretion mechanism, effector delivery, bacterial toxicity T6SS, inner tube, effector proteins, Escherichia coli, antibacterial, toxic, secretion system, Type VI, bacterial effector, microbial toxicity Type VI secretion system, T6SS, inner tube tip, toxic effector, antibacterial, Escherichia coli, E. coli, effector proteins, bacterial secretion, microbial toxins, pathogenic bacteria, bacterial machinery, effector delivery, bacterial virulence type VI secretion system, T6SS, inner tube, antibacterial effector, Escherichia coli, E. coli, toxic proteins, effector proteins, bacterial secretion, toxicity, microbiology, microbiological mechanisms type VI secretion system, T6SS, inner tube, effector proteins, antibacterial, Escherichia coli, E. coli, toxic effector, bacterial secretion, toxin delivery, microbiology, pathogenic bacteria
1395	p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). p16INK4A, accumulation, abnormal wound response, microinvasive, advanced, oral, potentially malignant lesions, OPMLs, wound healing, carcinogenesis, biomarkers, oral precancer, tumor suppressor, cellular response, malignant transformation p16INK4A, accumulation, abnormal wound response, microinvasive, advanced, oral, potentially malignant lesions, OPMLs, tumor suppressor, gingival, epithelial dysplasia, carcinogenesis p16INK4A,wound response,microinvasion,advanced OPMLs,oral lesions,malignant transformation,biomarker,cancer progression,molecular mechanisms,pre-cancerous lesions p16INK4A, accumulation, abnormal wound response, microinvasive, advanced, oral, potentially malignant lesions, OPMLs, cancer, precancerous, biomarkers, lesion progression, cellular mechanisms, molecular pathways p16INK4A, accumulation, abnormal wound response, microinvasive, advanced, Oral Potentially Malignant Lesions, OPMLs, lesion progression, oral carcinogenesis, molecular markers, tumor development, wound healing, cellular response, malignant transformation, head and neck pathology
1273	The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly. kinesin-8, Kip3, sliding activity, bipolar spindle, assembly, microtubules, motor protein, chromosome segregation, spindle dynamics, mitosis kinesin-8, Kip3, sliding activity, bipolar spindle, spindle assembly, microtubule dynamics, motor proteins, mitosis, chromosome segregation, cell division kinesin-8, Kip3, sliding activity, bipolar spindle, assembly, microtubules, motor protein, mitosis, chromosome segregation, cell division kinesin-8, Kip3, sliding activity, bipolar spindle, spindle assembly, microtubules, motor proteins, mitosis, chromosome segregation, molecular motors kinesin-8, Kip3, sliding activity, bipolar spindle assembly, microtubules, motor proteins, chromosome segregation, mitosis, spindle dynamics, cellular division
1272	The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells. ERG, flash-evoked, b-wave, ON-bipolar cells, retinal activity, electroretinogram, retinal pathways, visual processing, retinal response, neural activity flash-evoked ERG, b-wave, ON-bipolar cells, retinal electrophysiology, electroretinography, visual pathway, retinal activity, retina, neural response, trace analysis flash-evoked ERG, B-wave, ON-bipolar cells, retinal electrophysiology, electroretinogram, visual pathway, retinal activity, ON pathway, retinal response, electrophysiological markers flash-evoked, ERG, b-wave, ON-bipolar cells, retinal, electroretinography, visual pathway, retinal response, electrophysiology, retinal cells ERG, flash-evoked, b-wave, single, ON-bipolar cells, retinal electrophysiology, visual pathway, retinal response, electroretinogram, retinal cells
1150	Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia Tetraspanin-3, causative factor, acute myelogenous leukemia, AML, cancer, gene expression, cell proliferation, oncogenesis, hematological malignancy, molecular pathways, cancer biomarkers Tetraspanin-3, AML, acute myelogenous leukemia, causative factor, cancer biology, hematologic malignancies, cell surface proteins, oncology, gene expression, leukemia development Tetraspanin-3, AML, acute myelogenous leukemia, causative factor, leukemia development, cancer biomarkers, hematologic malignancies, cell signaling, tumor progression, gene expression Tetraspanin-3, acute myelogenous leukemia, AML, causative factor, cancer development, hematologic malignancy, cell surface protein, cancer pathogenesis, leukemia research, gene expression, tumor biology Tetraspanin-3, causative factor, acute myelogenous leukemia, AML, cancer biomarkers, molecular mechanisms, leukemia development, hematologic malignancies, cell signaling, gene expression
1271	The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI. cardiac involvement, amyloidosis, transmurality, late gadolinium enhancement, MRI, severity, cardiac, cardiac MRI, myocardial, myocardial fibrosis, gadolinium, imaging cardiac amyloidosis, transmurality, late gadolinium enhancement, MRI, cardiac involvement, severity, myocardium, gadolinium, imaging, cardiac MRI cardiac involvement, amyloidosis, transmurality, late gadolinium enhancement, MRI, severity, myocardial infiltration, cardiac amyloidosis, imaging biomarkers, cardiac MRI cardiac involvement, amyloidosis, severity, transmurality, late gadolinium enhancement, MRI, cardiac amyloidosis, myocardial fibrosis, imaging biomarkers, cardiac MRI amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI
1270	The risk of male prisoners harming themselves is ten times that of female prisoners. male prisoners, female prisoners, self-harm, prison risk, inmate safety, gender differences, prison mental health, inmate suicide, incarceration, self-injury prisoners, self-harm, gender, male, female, risk, mental health, incarceration, prison safety, suicide, vulnerability, inmate well-being male prisoners, female prisoners, self-harm, incarceration, prison safety, mental health, gender differences, suicide risk, inmate behavior, prison security prisoners, male, female, self-harm, risk, incarceration, gender differences, mental health, prisons, suicide, inmate safety prisoners, self-harm, male prisoners, female prisoners, mental health, incarceration, suicide risk, gender differences, prison environment, inmate well-being
163	Bariatric surgery has a positive impact on mental health. bariatric surgery, mental health, psychological benefits, weight loss, obesity treatment, postoperative mental health, depression, anxiety, psychological well-being, quality of life, mental health improvement, bariatric procedure, emotional health bariatric surgery, mental health, psychological effects, weight loss surgery, emotional well-being, depression, anxiety, body image, self-esteem, patient outcomes bariatric surgery, mental health, psychological benefits, weight loss, obesity treatment, emotional well-being, mental health improvement, postoperative mental health, bariatric procedure, psychological outcomes bariatric surgery, mental health, psychological benefits, weight loss, obesity treatment, postoperative mental health, psychological impact, mental well-being, surgical outcomes, depression, anxiety, quality of life bariatric surgery, mental health, psychological effects, obesity treatment, mental health benefits, bariatric procedures, psychological well-being, post-surgery outcomes, obesity psychology, mental health improvement
1029	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes. interleukin-2, regulatory T cells, responsiveness, autoimmune diseases, Type 1 Diabetes, immune regulation, T cell function, immune resistance, autoimmunity, cytokines interleukin-2, regulatory T cells, responsiveness, autoimmune diseases, Type 1 Diabetes, immune regulation, T cell function, immune response, autoimmunity, cytokines interleukin-2, regulatory T cells, responsiveness, autoimmune diseases, Type 1 Diabetes, immune regulation, T cell function, immune tolerance, cytokine signaling, immune resistance interleukin-2, responsiveness, regulatory T cells, autoimmune diseases, Type 1 Diabetes, resistance, immune regulation, T cell function, cytokines, immune response interleukin-2, regulatory T cells, responsiveness, autoimmune diseases, Type 1 Diabetes, immune regulation, T cell bioactivity, immune tolerance, immune resistance, cytokine signaling
960	Polymeal nutrition reduces cardiovascular mortality. Polymeal, nutrition, cardiovascular, mortality, heart health, diet, cardiac, dietary intervention, risk reduction, health outcomes Polymeal, nutrition, cardiovascular, mortality, heart health, diet, reversal, heart disease, preventive, lifestyle, evidence, clinical studies Polymeal, nutrition, cardiovascular health, mortality, heart disease, dietary intervention, cardioprotection, dietary patterns, health outcomes, dietary supplements Polymeal, nutrition, cardiovascular, mortality, heart health, diet, longevity, dietary intervention, disease prevention, cardiovascular disease, health benefits, nutritional supplements, lifestyle, clinical study, research Polymeal, nutrition, cardiovascular, mortality, heart health, dietary intervention, cardiovascular disease, prevention, lifestyle, dietary patterns
1389	mTORC2 regulates intracellular cysteine levels through xCT inhibition. mTORC2, cysteine, xCT, inhibition, intracellular, regulation, amino acids, transporter, signaling, metabolic pathways mTORC2, cysteine, xCT, intracellular, regulation, amino acids, transporter, inhibition, metabolism, signaling mTORC2, cysteine, xCT, inhibition, intracellular, regulation, amino acids, transporter, signaling pathway, cellular metabolism mTORC2, cysteine, xCT, inhibition, intracellular, regulation, amino acids, transporter, signaling pathway, cellular metabolism mTORC2, cysteine, xCT, intracellular, regulation, inhibition, amino acids, transporter, signaling pathways, metabolism, oxidative stress, cell growth
1146	Teaching hospitals do not provide better care than non-teaching hospitals. teaching hospitals, non-teaching hospitals, healthcare quality, patient outcomes, hospital comparison, medical education, hospital performance, healthcare quality metrics, teaching status, patient safety, healthcare research, clinical training teaching hospitals, non-teaching hospitals, healthcare quality, patient outcomes, medical education, hospital comparison, care quality, hospital performance, clinical outcomes, teaching hospital benefits teaching hospitals, non-teaching hospitals, healthcare quality, patient outcomes, hospital comparison, medical education, hospital performance, patient care, healthcare delivery, hospital accreditation teaching hospitals, non-teaching hospitals, patient care, quality of care, healthcare outcomes, hospital comparison, medical education, hospital performance, healthcare quality, patient satisfaction teaching hospitals, non-teaching hospitals, patient care, healthcare quality, hospital comparison, medical education, clinical outcomes, hospital performance, healthcare delivery, teaching hospital benefits
1024	Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes. recurrent mutations, CTCF, anchor sites, oncogenes, gene regulation, chromatin, genome stability, cancer genomics, regulatory elements, mutations, DNA binding sites, chromatin looping recurrent mutations, CTCF, anchor sites, oncogenes, chromatin architecture, genome regulation, mutation hotspots, gene regulation, enhancers, genome stability recurrent mutations, CTCF, anchor sites, oncogenes, chromatin architecture, gene regulation, genome stability, mutation hotspots, enhancer-promoter interactions, cancer genomics Recurrent mutations, CTCF, anchor sites, oncogenes, genetic mutations, chromatin architecture, genome regulation, gene enhancers, cancer genomics, mutation hotspots Recurrent mutations, CTCF anchor sites, oncogenes, chromatin organization, genome stability, regulatory elements, enhancer-promoter interactions, mutation hotspots, genetic variation
1266	The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer. breast cancer, parous women, placental weight, pregnancy, risk factors, premenopausal, hormone levels, reproductive history, pregnancy complications, tumor subtypes breast cancer, parous women, placental weight, pregnancy, risk factors, premenopausal, association, hormonal influence, reproductive history, epidemiology breast cancer, parous women, placental weight, pregnancy, premenopausal, risk factors, reproductive history, maternal health, hormone levels, breast tumor, estrogen, progesterone, epidemiology breast cancer, parous women, placental weight, pregnancy, risk factors, premenopausal, epidemiology, reproductive history, maternal health, tumor development breast cancer, parous women, placental weight, pregnancy, premenopausal, risk factors, reproductive history, hormone levels, tumor development, epidemiology
721	Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls. lupus, mice, infection, bacteria, curliproducing, autoantibodies, titers, autoimmune, model, immunology lupus, mice, infection, bacteria, curliproducing, autoantibody, titers, autoimmune, inflammation, immunology Lupus, mice, infection, bacteria, curliproducing, autoantibodies, titers, autoimmune, immunology, inflammation Lupus, mice, infection, bacteria, curliproduction, autoantibodies, titers, autoimmune, immune response, inflammation, autoimmune disease, experimental model, immunology lupus, mice, infection, bacteria, curliproducing, autoantibodies, titers, autoimmune, immunology, inflammation
1144	Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India. taxation, sugar-sweetened beverages, tax policy, public health, diabetes incidence, type II diabetes, India, policy effects, health economics, epidemiology, disease prevention taxation,sugar-sweetened beverages,type II diabetes,India,public health,policy impact,preventive measures,non-communicable diseases,health economics,public policy,health intervention Taxation, sugar-sweetened beverages, public health, diabetes, India, incidence, policy impact, health economics, behavioral response, non-communicable diseases taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, public health, policy, health economics, non-communicable diseases, preventive measures Taxation, sugar-sweetened beverages, SSBs, taxation impact, type II diabetes, diabetes incidence, public health policy, India, economic measures, health outcomes, preventive strategies, nutritional policies
723	Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions. Ly49Q, neutrophil migration, inflammation, membrane rafts, immune regulation, cell signaling, inflammation sites, neutrophil function, membrane microdomains, immune response Ly49Q, neutrophil migration, inflammation, membrane raft, cell signaling, immune response, receptor, inflammation sites, membrane organization, neutrophil activation Ly49Q, neutrophils, migration, inflammation, membrane rafts, cell signaling, immune response, receptor regulation, chemotaxis, immune cells Ly49Q, neutrophil migration, inflammation, membrane raft, immune regulation, cell signaling, immune response, chemotaxis, inflammation sites, immune cell, receptor, immune modulation, cell membrane Ly49Q, neutrophil migration, inflammation, membrane rafts, immune response, chemotaxis, cell signaling, immune receptors, inflammation site, neutrophil activation
845	Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils. Neutrophil extracellular traps, NETs, ANCA, neutrophils, immune response, autoimmunity, inflammation, neutrophil activation, immune regulation, pathogen defense neutrophil extracellular traps, NETs, ANCA, neutrophils, immune response, inflammation, autoimmunity, neutrophil activation, neutrophil degranulation, immune system, pathogen defense, immune regulation Neutrophil extracellular traps, NETs, ANCA, stimulated neutrophils, immune response, autoimmune disease, neutrophil activation, inflammation, microbial defense, NETosis, vasculitis, immune complexes neutrophil extracellular traps, NETs, ANCA, neutrophils, immune response, inflammation, autoimmunity, cell death, citrullination, neutrophil activation Neutrophil extracellular traps, NETs, ANCA, neutrophils, immune response, autoimmunity, inflammation, neutrophil activation, extracellular DNA, antimicrobial defense
967	Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation. Arp2/3 complex, CK-666, pretreatment, lamellipodia, cell motility, actin polymerization, cytoskeleton, proline-rich protein, cell migration, actin branching, inhibitor, cell morphology Pretreatment, Arp2/3, CK-666, lamellipodia, formation, actin polymerization, cytoskeleton, cell motility, cellular dynamics, inhibitor effects pretreatment, Arp2/3 inhibitor, CK-666, lamellipodia, formation, cell motility, actin polymerization, cytoskeleton, cell migration, inhibitor effects Pretreatment, Arp2/3 inhibitor, CK-666, lamellipodia, formation, cell motility, actin polymerization, cytoskeleton, cell migration, cell morphology Arp2/3 complex, CK-666, lamellipodia, cell migration, actin polymerization, cytoskeleton, inhibitor effects, cell motility, actin dynamics, cytoskeletal remodeling
847	New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations. tuberculosis, drugs, necrotic lesion, drug penetration, high concentration, tuberculosis treatment, drug delivery, lesion penetration, tuberculosis pathology, antimicrobial penetration tuberculosis, new drugs, drug penetration, necrotic lesion, high concentration, tuberculosis treatment, drug delivery, lesion penetration, antimicrobial efficacy, caseous necrosis, pulmonary tuberculosis, pharmacokinetics tuberculosis, drugs, necrotic, lesion, penetration, high concentration, antimicrobial, pharmacokinetics, drug delivery, caseous, granuloma, treatment, resistance tuberculosis, new drugs, drug penetration, necrotic lesion, lesion penetration, high concentration, tuberculosis treatment, drug delivery, drug efficacy, necrosis, antimicrobial penetration, tuberculosis pathology, drug resistance tuberculosis, new drugs, drug penetration, necrotic lesion, high concentration, tuberculosis treatment, drug delivery, lesion necrosis, antimicrobial penetration, tuberculosis pathology
727	Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts. Ly6C, monocytes, inflammatory capacity, immune response, Ly6C high, Ly6C low, inflammation, immune cells, monocyte subsets, inflammatory potential Ly6C, monocytes, inflammatory capacity, Ly6C high, Ly6C low, immune response, inflammation, immune cells, monocyte subsets, immune modulation Ly6C, monocytes, inflammatory capacity, cell subsets, immune response, high vs low expression, inflammation, immune cells, monocyte differentiation, immune regulation Ly6C, monocytes, inflammatory capacity, Ly6C hi, Ly6C lo, immune response, inflammation, myeloid cells, cytokines, monocyte subsets Ly6C, monocytes, inflammatory capacity, Ly6C high, Ly6C low, immune response, inflammation, immune cells, monocyte subsets, cytokine production
728	Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes. Ly6C, monocytes, inflammatory capacity, Ly6C high, Ly6C low, immune response, inflammation, monocyte subsets, cytokine production, immune cells Ly6C, monocytes, inflammatory capacity, Ly6C high, Ly6C low, immune response, inflammatory response, monocyte subsets, cytokine production, immune regulation Ly6C, monocytes, inflammatory capacity, Ly6C hi, Ly6C lo, immune response, inflammation, immune cells, monocyte subsets, inflammation regulation Ly6C, monocytes, high, low, inflammatory, capacity, immune response, inflammation, immune cells, subsets, immune system Ly6C, monocytes, high, low, inflammatory, capacity, immune response, cytokines, inflammation, myeloid cells, immune regulation
729	Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway. Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, immune response, lymph nodes, genetic modification, signaling pathway, inflammation, mouse model Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, immune response, lymphatic system, signaling pathway, genetic modification, mouse model, lymph node enlargement Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, immune response, lymph nodes, signaling pathway, genetic modification, kinase signaling, mouse model Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, immune response, lymph node enlargement, signaling pathways, genetic modification, immunology, pathology Lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, immune response, lymph nodes, signaling pathways, genetic modification, mouse model, cytokines, immune regulation
1163	The DdrB protein from Deinococcus radiodurans is an alternative SSB. DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, DNA repair, stress response, extremophile, protein function, DNA stabilization, radiation resistance DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, DNA repair, radioprotection, DNA binding, protein function, bacterial proteins, molecular biology DdrB, Deinococcus radiodurans, protein, SSB, single-strand DNA-binding protein, DNA repair, DNA stability, DNA binding, radiation resistance, microbial proteins DdrB, Deinococcus radiodurans, protein, SSB, single-stranded DNA binding, DNA repair, radiation resistance, DNA stabilization, DNA binding proteins, DNA metabolism DdrB, Deinococcus radiodurans, SSB, single-strand binding protein, DNA repair, radiation resistance, protein function, DNA stabilization, stress response, alternative SSB
1041	Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes. histone H2A, H2A.Z, gene activation, yeast, nucleosomes, chromatin remodeling, transcription regulation, histone variants, nucleosome stability, gene expression, +1 nucleosome, epigenetics histone H2A, H2A.Z, gene activation, yeast, nucleosomes, +1 nucleosome, chromatin remodeling, histone exchange, transcription regulation, nucleosome stability, epigenetics, chromatin structure histone H2A, H2A.Z, gene activation, yeast, nucleosomes, +1 nucleosomes, chromatin remodeling, histone exchange, gene regulation, transcription, nucleosome stability histone H2A, H2A.Z, gene activation, yeasts, nucleosome stabilization, +1 nucleosome, chromatin remodeling, transcription regulation, histone exchange, epigenetics histone H2A, H2A.Z, gene activation, yeast, nucleosome stability, +1 nucleosome, chromatin remodeling, transcription regulation, histone variants, epigenetics
171	Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). Basophils, disease development, systemic lupus erythematosus, SLE, immune response, autoimmunity, inflammation, eosinophils, immune cells, autoimmune diseases Basophils, disease development, systemic lupus erythematosus, SLE, immune response, autoimmune, inflammation, immune regulation, pathology, immune cells, hematology Basophils, autoimmune, systemic lupus erythematosus, SLE, immune response, inflammation, disease development, immune cells, hematology, immune regulation Basophils, disease development, systemic lupus erythematosus, SLE, immune response, autoimmunity, inflammation, immune regulation, pathological processes, hematology Basophils, systemic lupus erythematosus, SLE, immune response, autoimmune diseases, disease development, immune regulation, inflammatory response, immune cells, immune system, autoimmunity, immune modulation, disease progression
1282	Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence. Dapsone, pyoderma gangrenosum, treatment, therapeutic use, anecdotal evidence, skin condition, dermatitis, neutrophilic dermatosis, dermatology, case reports, drug efficacy Dapsone, pyoderma gangrenosum, therapeutic use, treatment, anecdotal evidence, drug efficacy, dermatology, skin ulcer, anti-inflammatory, antimicrobial, clinical studies Therapeutic use,dapsone,treat,pyoderma gangrenosum,drug,evidence,clinical studies,case reports,dermatology,antimicrobial,anti-inflammatory Dapsone, pyoderma gangrenosum, therapeutic use, anecdotal evidence, treatment, dermatology, anti-inflammatory, antibiotic, neutrophilic dermatosis Dapsone,therapeutic use,pyoderma gangrenosum,treatment,medical evidence,clinical application,dermatology,antimicrobial,anti-inflammatory,case reports,skin ulcer,dermatological therapy
1281	The ureABIEFGH gene cluster is induced by nickel (II) ion. ureABIEFGH, gene cluster, induction, nickel(II) ion, metal ion response, gene regulation, bacterial genes, metal resistance, metalloprotein, gene expression ureABIEFGH, gene cluster, induction, nickel ion, metal regulation, gene expression, bacterial genes, metal response, nickel toxicity, genetic regulation ureABIEFGH, gene cluster, nickel, nickel (II) ion, induction, gene expression, metal ion, bacterial genetics, metalloregulation, metal response ureABIEFGH, gene cluster, induction, nickel, nickel (II), metal ion, gene expression, metal regulation, bacterial genetics, metalloregulation ureABIEFGH, gene cluster, induction, nickel, Ni(II), metal ion, gene expression, metalloregulation, bacterial genetics, metal response
294	Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae. crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination hotspots, genomic regions, yeast genetics, DNA replication, recombination frequency, chromatin structure, genome annotation crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, genomic regions, DNA translation, recombination frequency, hot spot localization, promoter regions, yeast genetics crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, genomic regions, hotspot analysis, yeast genetics, DNA recombination, crossover frequency, promoter regions, genome structure crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, hotspot localization, genome architecture, meiotic recombination, DNA sequences, chromatin structure, genetic recombination crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination hotspots, genome regions, genetic recombination, DNA hotspots, yeast genetics, meiotic recombination, genomic localization
1280	The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG. ureABIEFGH, gene cluster, urease maturation, UreD, UreH, UreE, UreF, UreG, protein complex, enzyme assembly, microbial genetics, enzyme maturation, Urease biosynthesis ureABIEFGH, gene cluster, urease, maturation proteins, UreD, UreH, UreE, UreF, UreG, enzyme biosynthesis, genetic encoding, microbial enzymes, protein complexes ureABIEFGH, gene cluster, urease maturation, UreD, UreH, UreE, UreF, UreG, gene encoding, protein complex, enzymatic activity, bacterial genes ureABIEFGH, gene cluster, urease maturation, UreD, UreH, UreE, UreF, UreG, proteins, enzyme activation, nitrogen metabolism ureABIEFGH, gene cluster, urease maturation, proteins, UreD, UreH, UreE, UreF, UreG
295	Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis. crosstalk, dendritic cells, DCs, innate lymphoid cells, ILCs, intestinal homeostasis, immune regulation, mucosal immunity, immune interaction, immune signaling dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, interaction, intestinal homeostasis, immune regulation, mucosal immunity, immune cell communication, gut immunity dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, gut immunity, immune cell interaction, mucosal immunity dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, mucosal immunity, cell communication, immune cells dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, cell interaction, intestinal homeostasis, immune regulation, mucosal immunity, immune cells, immune response
298	Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis. Cytochrome c, mitochondrial, intermembrane space, cytosol, apoptosis, release, programmed cell death, mitochondrial pathways, apoptosis signaling, cell death mechanisms Cytochrome c, mitochondrial intermembrane space, apoptosis, cytosol, release, mitochondrial membrane, programmed cell death, caspases, mitochondrial permeability transition, apoptotic pathway cytochrome c, mitochondrial, intermembrane space, cytosol, apoptosis, release, mitochondrial membrane, programmed cell death, caspases, intrinsic pathway Cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, release, mitochondrial membrane, apoptotic pathway, cell death, mitochondrial outer membrane, caspases, mitochondrial permeabilization, intrinsic pathway Cytochrome c, mitochondrial, intermembrane space, cytosol, apoptosis, release, signaling, cell death, mitochondrial membrane, apoptotic pathway
179	Birth-weight is positively associated with breast cancer. birth weight, breast cancer, association, risk factors, epidemiology, maternal health, fetal development, cancer risk, prenatal factors, epidemiological studies birth weight, breast cancer, pregnancy, fetal development, epidemiology, maternal health, risk factors, pregnancy outcomes, obstetrics, oncology birth weight, breast cancer, prenatal factors, fetal development, maternal health, cancer risk, epidemiology, maternal nutrition, fetal growth, probability, risk factors birth weight, breast cancer, pregnancy, fetal development, epidemiology, maternal health, cancer risk, prenatal factors, low birth weight, high birth weight birth weight, breast cancer, correlation, epidemiology, risk factors, maternal health, offspring health, case-control study, observational study, gestational weight, prenatal factors, maternal nutrition, childhood health, cancer risk, health outcomes
971	Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. primary, cervical cancer, screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, grade 2, HPV testing, Pap smear, lesion detection, diagnostic accuracy cervical cancer, HPV detection, screening, cytology, sensitivity, longitudinal, intraepithelial neoplasia, CIN, grade 2, comparative, diagnostic accuracy cervical cancer, HPV detection, screening, longitudinal sensitivity, cytology, cervical intraepithelial neoplasia, grade 2, high-risk HPV, diagnostic accuracy, HPV testing, Pap smear, cervical screening methods cervical cancer, HPV detection, screening, sensitivity, cytology, longitudinal, intraepithelial neoplasia, CIN, grade 2, HPV testing, diagnostic accuracy cervical cancer, screening, HPV detection, longitudinal sensitivity, cytology, cervical intraepithelial neoplasia, CIN2, HPV testing, Pap smear, cervical screening methods
1279	The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events. cancer, treatment, co-IR blockade, immune checkpoint blockade, adverse events, autoimmune, immunotherapy, immune-related adverse events, irAEs, cancer immunotherapy cancer, treatment, co-IR blockade, immune-related adverse events, autoimmune, immunotherapy, immune checkpoint inhibitors, adverse effects, oncology, immunology cancer, treatment, co-IR blockade, immune-related adverse events, autoimmune, immunotherapy, immune checkpoint, adverse effects, cancer therapy, immune system cancer, treatment, co-IR blockade, immune checkpoint inhibitors, adverse events, autoimmune, immune-related adverse events, immunotherapy, immune system, toxicity cancer treatment, immune checkpoint blockade, co-inhibitory receptors, autoimmune adverse events, immunotherapy, immune-related adverse events, PD-1, CTLA-4, immune system, oncology, adverse event management
1278	The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events. cancer, treatment, co-IR blockade, autoimmune events, adverse effects, immunotherapy, immune checkpoint inhibitors, cancer therapy, immune regulation, immune-related adverse events cancer, treatment, co-IR blockade, autoimmune events, adverse effects, immunotherapy, immune checkpoint inhibitors, patient safety, immune-related adverse events, cancer immunotherapy cancer, treatment, co-IR blockade, adverse events, autoimmune, immunotherapy, immune checkpoint inhibitors, safety, side effects, oncology cancer, treatment, co-IR blockade, adverse events, autoimmune, immunotherapy, immune checkpoint inhibitors, cancer therapy, immune-related adverse events, safety, autoimmune reactions cancer, patients, co-IR blockade, immune-related adverse events, autoimmune, immunotherapy, adverse effects, immune checkpoint inhibitors, treatment, safety
852	Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment. non-invasive ventilation, NIV, treatment response, inadequate, decrease, reduce, conventional treatment, respiratory support, therapy adjustment, clinical guidelines non-invasive ventilation, NIV, respiratory support, inadequate response, conventional treatment, decrease, weaning, respiratory failure, clinical guidelines, patient management non-invasive ventilation, decrease, inadequate response, conventional treatment, respiratory support, ventilation management, patient response, treatment effectiveness non-invasive ventilation, ventilation, decrease, reduce, inadequate response, conventional treatment, management, respiratory support, treatment failure, clinical guidelines non-invasive ventilation, ventilation, respiratory support, inadequate response, conventional treatment, decrease, reduction, respiratory management, hypoxia, patient response
975	Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators. primary, pro-inflammatory, cytokines, secondary, mediators, anti-inflammatory, immune response, cytokine signaling, inflammation cascade, immune regulation cytokines, pro-inflammatory, anti-inflammatory, secondary mediators, immune response, inflammation, cytokine signaling, immune regulation, inflammatory cascade, cytokine induction cytokines, pro-inflammatory, anti-inflammatory, mediators, secondary response, immune response, cytokine signaling, inflammation, cytokine cascade, immune regulation primary, pro-inflammatory, cytokines, secondary, mediators, anti-inflammatory, immune response, inflammation, signaling pathways, cytokine cascade, immune regulation pro-inflammatory cytokines, secondary mediators, anti-inflammatory mediators, cytokine signaling, immune response, inflammation, cytokine cascade, immune regulation, inflammatory pathways, mediator induction
613	Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits. microtubule, acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neurodegeneration, neuronal repair, microtubule stability, kinase activity, Parkinson's disease, neuroprotective, neuronal function, molecular pathways microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neuronal repair, neurodegeneration, microtubule stability, kinase activity, dopaminergic neurons microtubule, acetylation, LRRK2, Roc-COR, mutation, locomotor deficits, neural repair, neurodegeneration, motor function, microtubule stabilization, neuronal signaling microtubules, acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neurodegeneration, neuronal repair, motor function, protein modification, cellular repair, neurodegenerative diseases microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neuronal repair, neurodegeneration, post-translational modifications, motor function, cellular mechanisms
70	Activation of PPM1D suppresses p53 function. PPM1D, activation, suppression, p53, tumor suppressor, phosphatase, DNA damage response, cell cycle, oncogene, cancer, gene regulation PPM1D, activation, suppression, p53, tumor suppression, phosphatase, DNA damage response, cell cycle regulation, oncogene, protein phosphatase, molecular pathway PPM1D, activation, suppression, p53, tumor suppressor, phosphatase, DNA damage response, cell cycle, oncogene, tumorigenesis PPM1D, activation, p53, tumor suppressor, phosphatase, DNA damage response, cancer, cell cycle, gene regulation, protein interaction PPM1D, activation, p53, suppression, tumor suppressor, phosphatase, DNA damage response, oncogene, cell cycle, apoptosis
72	Activator-inhibitor pairs are provided dorsally by Admpchordin. activator, inhibitor, pairs, dorsally, Admp, chordin activator, inhibitor, pairs, dorsal, adipocyte-derived morphogen controlling, Admpchordin, signaling pathways, embryonic development, dorsal-ventral axis, morphogen gradient, regulatory mechanisms Activator-inhibitor, pairs, dorsally, Admp, chordin Activator-inhibitor, pairs, dorsally, Admpchordin, developmental biology, signaling pathways, embryonic dorsoventral patterning, BMP signaling, gene regulation, morphogen gradients activator, inhibitor, pairs, dorsal, Admp, chordin, signaling, embryonic development, morphogens, gradient, regulation
859	Normal expression of RUNX1 has tumor-promoting effects. RUNX1, tumor promotion, gene expression, cancer, transcription factors, oncology, tumor suppressor, oncogene, gene regulation, molecular pathways RUNX1, tumor-promoting, gene expression, cancer, oncogenesis, transcription factor, hematologic malignancy, leukemia, molecular pathway, gene regulation RUNX1, normal expression, tumor promotion, oncogenesis, gene regulation, transcription factor, cancer, cellular proliferation, tumor progression, molecular pathways RUNX1, tumor promotion, gene expression, oncogenesis, transcription factors, cancer biology, hematological malignancies, gene regulation, tumor suppressor, oncogene RUNX1, gene expression, tumor promotion, oncogenesis, transcription factor, cancer, molecular pathways, cellular proliferation, gene regulation, tumor suppressor, oncogene, hematologic malignancies, transcriptional activity
619	Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments. vessel density, fibrosis, chemotherapy efficacy, tumor vasculature, angiogenesis, treatment resistance, tumor microenvironment, vascular normalization, drug delivery, tumor fibrosis vessel density, fibrosis, chemotherapy efficacy, tumor microenvironment, angiogenesis, drug resistance, tumor vasculature, extracellular matrix, treatment response, tumor progression vessel density, fibrosis, chemotherapy, treatment efficacy, tumor vasculature, fibrosis reduction, drug delivery, tumor microenvironment, angiogenesis, therapeutic response vessel density, fibrosis, chemotherapy efficacy, tumor microenvironment, angiogenesis, fibrosis reduction, treatment resistance, tumor vasculature, drug delivery, stromal remodeling vessel density, fibrosis, chemotherapy efficacy, tumor microenvironment, angiogenesis, tissue remodeling, treatment resistance, vascularization, extracellular matrix, drug delivery
75	Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. H. pylori, urease, active enzyme, polymeric structure, UreA, UreB, subunits, enzyme function, bacterial enzymes, urease activity, structural biology, microbiology H. pylori, urease, polymeric structure, UreA, UreB, enzyme, subunits, active site, microbiology, protein structure, enzyme mechanism H pylori, urease, active, polymeric, structure, subunits, UreA, UreB, enzyme, bacteria, pathogenicity, protein, enzyme activity, molecular structure H. pylori, urease, active enzyme, polymeric structure, UreA, UreB, subunits, enzyme structure, bacterial urease, urease function, microbial enzymes H. pylori, urease, polymeric structure, UreA, UreB, enzyme activity, bacterial enzymes, urease subunits, enzyme structure, microbial enzymes
1175	The PPR MDA5 has two N-terminal CARD domains. PPR, MDA5, N-terminal, CARD, domains, pattern recognition, immune response, antiviral, innate immunity, RIG-I-like receptors PPR, MDA5, N-terminal, CARD, domains, pattern recognition receptors, innate immunity, antiviral response, RIG-I-like receptors, mitochondrial antiviral-signaling pathway PPR, MDA5, N-terminal, CARD, domains, pattern recognition receptor, innate immunity, antiviral response, RIG-I-like receptor, mitochondrial antiviral-signaling, signaling cascade, interferon induction PPR, MDA5, N-terminal, CARD, domains, innate immunity, pattern recognition receptor, RIG-I-like receptor, antiviral response, RNA sensing PPR, MDA5, N-terminal, CARD, domains, pattern recognition receptor, RIG-I-like receptors, innate immunity, antiviral response, mitochondrial antiviral signaling, RNA sensors
180	Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. TDP-43, respiratory complex I, ND3, ND6, protein interaction, neuronal loss, neurodegeneration, mitochondrial dysfunction, protein aggregation, neurotoxicity TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, neurodegeneration, mitochondrial dysfunction, protein blocking, neurodegenerative diseases TDP-43, respiratory complex I, ND3, ND6, protein interaction, neuronal loss, neurodegeneration, mitochondrial dysfunction, protein blocking, molecular pathway, TDP-43 toxicity TDP-43, respiratory complex I, ND3, ND6, interaction, inhibition, neuronal loss, neurodegeneration, mitochondrial dysfunction, protein-protein interaction, neurotoxicity, TDP-43 aggregation, mitochondrial complex, neurodegenerative diseases TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, neurodegeneration, mitochondrial dysfunction, protein aggregation, neurodegenerative diseases
183	Bone marrow cells contribute to adult macrophage compartments. bone marrow, cells, adult, macrophage, compartments, contribution, hematopoiesis, immune system, myeloid lineage, tissue-resident macrophages Bone marrow, adult macrophages, immune cells, hematopoiesis, monocytes, tissue-resident macrophages, cell differentiation, myeloid lineage, stem cells, macrophage origins bone marrow, cells, adult, macrophage, compartments, hematopoiesis, immune system, monocytes, differentiation, tissue-resident macrophages, myeloid lineage, hematopoietic stem cells bone marrow, adult macrophages, cell contribution, hematopoiesis, immune system, myeloid cells, macrophage origins, tissue-resident macrophages, monocyte differentiation, stem cells bone marrow, cells, adult, macrophage, compartments, hematopoiesis, myeloid, immune system, differentiation, stem cells
1292	There is no association between HNF4A mutations and diabetes risks. HNF4A, mutations, diabetes, risks, association, genetic, gene, variation, metabolic, inheritance, type 2 diabetes, monogenic, gene mutation, pancreatic beta cells HNF4A, mutations, diabetes, risks, association, genetic, gene, mutation, study, correlation, epidemiology, genetics, prevalence, diabetes mellitus, genetic disorders HNF4A, mutations, diabetes, risks, association, genetic, genes, glucose metabolism, pancreatic beta cells, hereditary, research, correlation HNF4A, mutations, diabetes, risks, association, genetic, correlation, inheritance, type 2 diabetes, pancreatic beta cells, gene mutations, genetic risk factors HNF4A, mutations, diabetes, risk, association, genetic, gene, diabetes type 2, hereditary, polymorphism, epidemiology, genetic variation
185	Breast cancer development is determined exclusively by genetic factors. breast cancer, development, genetic factors, cancer risk, heredity, genetics, tumor biology, oncogenes, gene mutations, hereditary breast cancer Breast cancer, genetic factors, development, risk, heredity, DNA, mutations, inheritance, oncogenes, tumors Breast cancer, development, genetic factors, risk factors, heredity, mutations, DNA, genetics, oncogenes, tumor suppressor genes, hereditary breast cancer, BRCA1, BRCA2, gene mutations breast cancer, development, genetic factors, causes, risk factors, heredity, genetics, oncogenes, tumor suppressor genes, environmental influences, non-genetic factors, lifestyle, mutations, DNA, hereditary breast cancer breast cancer, development, genetic factors, heredity, risk factors, gene mutations, BRCA1, BRCA2, DNA, tumor suppressor genes, hereditary, non-genetic factors, environment, lifestyle
1290	There is an inverse relationship between hip fractures and statin use. hip fractures, statin use, inverse relationship, osteoporosis, lipid-lowering drugs, fracture risk, cardiovascular medication, bone health, epidemiology, medication effects hip fractures, statin use, inverse relationship, osteoporosis, bone health, lipid-lowering therapy, epidemiology, risk factors, medication effects, clinical studies hip fractures, statin use, inverse relationship, osteoporosis, cardiovascular drugs, bone health, risk factors, treatment effects, epidemiology, pharmacology hip fractures, statin use, inverse relationship, osteoporosis, cardiovascular drugs, bone health, epidemiology, medication effects, fall risk, fracture prevention hip fractures, statin use, inverse relationship, osteoporosis, cardiovascular drugs, fracture risk, lipid-lowering medication, bone health, epidemiology, medication effects
1049	Ribosomopathies have a low degree of cell and tissue specific pathology. Ribosomopathies, cell specificity, tissue specificity, pathology, genetic mutations, ribosomal proteins, translational defects, disease mechanisms, tissue susceptibility, developmental disorders Ribosomopathies, cell specificity, tissue specificity, pathology, ribosomal dysfunction, genetic disorders, cellular processes, tissue pathology, disease mechanisms, ribosomal proteins, gene mutations ribosomopathies, cell specificity, tissue specificity, pathology, genetic disorders, ribosomal function, ribosomal DNA, mutations, hematological disorders, cancer associations, developmental abnormalities ribosomopathies, cell specificity, tissue specificity, pathology, ribosome dysfunction, genetic disorders, ribosomal proteins, ribosomal biogenesis, disease mechanisms, cellular impact ribosomopathies, cell specificity, tissue pathology, genetic disorders, ribosomal dysfunction, tissue-specific effects, disease mechanisms, cellular pathology, ribosome biogenesis
982	Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body. proteins, synthesis, growth cone, ubiquitination, cell body, rate, protein degradation, neuronal transport, post-translational modification, axonal transport, protein turnover proteins, synthesized, growth cone, ubiquitination, cell body, neuronal, axonal transport, protein degradation, post-translational modification, local translation proteins, synthesis, growth cone, ubiquitination, protein degradation, neuronal transport, localized translation, axonal proteins, post-translational modification, protein turnover proteins, synthesis, growth cone, ubiquitination, cell body, neuron, trafficking, degradation, protein modification, neural development proteins, synthesis, growth cone, ubiquitination, cell body, protein degradation, axonal transport, post-translational modification, neuronal development, protein turnover
742	Macrolides have no protective effect against myocardial infarction. Macrolides, protective effect, myocardial infarction, cardiovascular health, antibiotic, anti-inflammatory, cardiac risk, heart attack, antibiotic resistance, clinical studies Macrolides, protective effect, myocardial infarction, cardiac health, antibiotics, cardiovascular, anti-inflammatory, infection, risk factors, cardiovascular risk, heart disease, clinical studies Macrolides, protective effect, myocardial infarction, cardiovascular health, antibiotics, cardiac risk, therapy impact, anti-inflammatory, lipid profile, clinical outcomes Macrolides, protective effect, myocardial infarction, cardiovascular, antibiotics, heart attack, cardiovascular risk, anti-inflammatory, antibiotic resistance Macrolides, protective effect, myocardial infarction, cardiovascular, antibiotics, anti-inflammatory, heart disease, coronary events, infection, drug efficacy
501	Headaches are not correlated with cognitive impairment. headaches, cognitive impairment, correlation, neurological, pain, brain function, neuroimaging, clinical study, symptom, diagnosis headaches, cognitive impairment, correlation, relationship, neurological, brain, symptom, diagnosis, research, health headaches, cognitive impairment, correlation, neurological disorders, symptom analysis, brain health, migraine, tension headache, cluster headache, neurocognitive function, brain imaging, mental health, neurological assessment headaches, cognitive impairment, correlation, neurological, pain, cognition, brain health, migraine, headache types, neurological disorders headaches,cognitive impairment,correlation,migraine,neurological disorders,pain,brain health,neuropsychology,clinical studies,patient outcomes
743	Macrolides protect against myocardial infarction. Macrolides, antibiotics, myocardial infarction, heart attack, cardiovascular, cardiovascular disease, anti-inflammatory, infection, coronary artery disease, prevention, cardioprotection Macrolides, antibiotics, myocardial infarction, cardiovascular protection, anti-inflammatory effects, antibiotic therapy, cardiac health, cardiovascular risk reduction Macrolides, antibiotics, myocardial infarction, cardiovascular, heart attack, anti-inflammatory, cardioprotection, infection, immune response, plaque stability Macrolides, antibiotics, cardiovascular protection, myocardial infarction, heart disease, anti-inflammatory, antibiotic therapy, cardiovascular risk, infection, anti-inflammatory mechanism Macrolides, antibiotics, cardiovascular, myocardial infarction, MI, cardiovascular protection, anti-inflammatory, infection, antibiotic therapy, cardiovascular risk, heart attack prevention
985	Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy. Pseudogene, PTENP1, PTEN, gene regulation, miRNA decoy, non-coding RNA, gene expression, gene silencing, competitive endogenous RNA, ceRNA, microRNA, cancer biology, tumor suppressor, post-transcriptional regulation Pseudogene, PTENP1, regulation, PTEN, gene expression, miRNA decoy, gene regulation, non-coding RNA, pseudogene function, gene expression modulation Pseudogene, PTENP1, PTEN, regulation, gene expression, miRNA decoy, non-coding RNA, pseudogene function, gene regulation, microRNA, competitive endogenous RNA, ceRNA, RNA interference, gene expression control Pseudogene, PTENP1, regulation, PTEN, miRNA decoy, gene expression, non-coding RNA, gene regulation, competitive endogenous RNA, ceRNA, non-coding pseudogene, tumor suppressor, gene interaction Pseudogene, PTENP1, PTEN, gene regulation, miRNA decoy, non-coding RNA, gene expression, pseudogene function, competitive endogenous RNA, ceRNA, microRNA, gene regulation mechanism
502	Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements. healthcare, delivery, efficiency, crowded centers, structural elements, logistical elements, interpersonal elements, healthcare delivery, operational efficiency, healthcare logistics, patient flow, healthcare infrastructure, communication, teamwork, process improvement healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement healthcare, delivery, efficiency, crowded, centers, structural, logistical, interpersonal, elements, improvement
623	Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis. vitamin D, serum concentration, low levels, multiple sclerosis, MS, risk factors, deficiency, autoimmune disease, inflammation, epidemiology, vitamin D supplementation vitamin D, serum concentration, low vitamin D, multiple sclerosis, MS risk, vitamin D deficiency, autoimmune disease, neurological health, vitamin D levels, immune function vitamin D, serum concentration, low levels, multiple sclerosis, MS, risk factors, deficiency, epidemiology, immune response, neurologic disease vitamin D, serum concentrations, low, multiple sclerosis, MS, deficiency, risk factors, epidemiology, immune response, autoimmune diseases, vitamin D deficiency, neurological disorders vitamin D, serum levels, low vitamin D, multiple sclerosis, MS, autoimmune, deficiency, risk factors, neurologic disorder, immune system
744	Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein. Macropinocytosis, amino acids, intracellular uptake, protein, cell metabolism, nutrient acquisition, endocytosis, cellular intake Macropinocytosis, amino acids, intracellular uptake, protein, cell metabolism, nutrient acquisition, endocytosis, cellular process, membrane ruffling, intracellular trafficking macropinocytosis, amino acids, intracellular uptake, protein, cell supply, endocytosis, nutrient acquisition, cellular metabolism, membrane dynamics, lysosomal degradation macropinocytosis, amino acids, intracellular uptake, protein, cell metabolism, nutrient acquisition, endocytosis, cellular nutrition, membrane dynamics, cellular feeding macropinocytosis, amino acids, intracellular uptake, protein, cell, nutrient acquisition, endocytosis, cellular metabolism
507	Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication. helminths, immune system, macrophages, IL-4, immune modulation, Mycobacterium tuberculosis, pathogen interaction, parasitic infection, immune evasion, cytokines, immune response, infectious disease Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, immune response, parasitic infections, immune modulation, pathogen interaction helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, interference, immune modulation, host-pathogen interaction, parasitic infections, cytokines, Th2 response helminths, immune system, macrophages, IL-4, activation, Mycobacterium tuberculosis, replication, interference, immune response, parasitic infections, host-pathogen interaction helminths, immune system, macrophages, IL-4, activation, Mycobacterium tuberculosis, replication, immune modulation, parasitic infections, immunology, cytokines, immune response, host-pathogen interactions
628	Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin. Infection, human T-cell lymphotropic virus type 1, HTLV-1, prevalence, African populations, epidemiology, tropical regions, transmission, risk factors, endemic areas, retrovirus Infection, human T-cell lymphotropic virus type 1, HTLV-1, prevalence, geographic distribution, African origin, endemic areas, retrovirus, transmission, epidemiology, risk factors, clinical features, demographic factors HIV,HTLV-1,infection,prevalence,ethnicity,Africa,transmission,T-cell,lymphotropic,virus,genetics,risk factors,epidemiology,molecular biology Infection, human T-cell lymphotropic virus, HTLV-1, geographic distribution, African origin, prevalence, epidemiology, transmission, risk factors, racial and ethnic differences, tropical diseases Infection, Human T-cell lymphotropic virus type 1, HTLV-1, prevalence, African origin, epidemiology, viral transmission, endemic areas, retrovirus, risk factors, demographic factors
508	Hematopoietic Stem Cell purification reaches purity rate of up to 50%. hematopoietic stem cells, cell purification, purity rate, stem cell isolation, purification techniques, hematopoiesis, stem cell sorting, cell separation, cell purity, stem cell research Hematopoietic, Stem Cell, purification, purity, rate, efficiency, isolation, separation, stem cell therapy, cell sorting, purification techniques, blood stem cells, CD34, cell purity, transplantation Hematopoietic, Stem Cells, purification, cell sorting, purity, isolation, stem cell therapy, regenerative medicine, flow cytometry, cell separation, CD34, immune-magnetic separation, stem cell marker, cell viability, experimental protocol Hematopoietic Stem Cells, cell purification, purity rate, stem cell isolation, hematopoiesis, stem cell therapy, cell sorting, flow cytometry, CD markers, progenitor cells, regenerative medicine Hematopoietic, stem cells, purification, purity rate, cell sorting, stem cell isolation, flow cytometry, CD34+, stem cell therapy, regenerative medicine
1187	The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription. YAP1, TEAD, complex, translocation, nucleus, transcription factors, DNA-binding proteins, gene transcription, cell signaling, protein interaction, gene regulation YAP1, TEAD, translocates, nucleus, transcription factors, DNA-binding proteins, target gene, transcription, complex YAP1, TEAD, complex, translocation, nucleus, transcription factors, DNA-binding proteins, gene transcription YAP1, TEAD, complex, translocation, nucleus, transcription factors, DNA-binding proteins, gene transcription YAP1, TEAD, complex, translocation, nucleus, transcription factors, DNA-binding proteins, gene transcription
1185	The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. US health care, savings, $750 million, kidney transplants, patient participation, kidney paired donation, national program, transplantation efficiency, healthcare costs, transplant waiting list US, health care, kidney transplants, cost savings, kidney paired donation, national program, patient waiting list, transplant efficiency, healthcare economics, transplant sustainability US, health care, kidney transplants, savings, $750 million, patient waiting, kidney paired donation, national program, optimized, efficiency, transplantation system, resource management US health care system, cost savings, $750 million, kidney transplants, patient participation, national kidney paired donation, optimized program, waitlist reduction, organ donation, healthcare efficiency US health care, kidney transplants, cost savings, kidney paired donation, donation program, patient participation, transplant waiting list, healthcare costs, transplant system efficiency, national kidney program
1062	S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases. S-nitrosylation, GAPDH, histone deacetylases, transnitrosylation, nitric oxide, enzyme modification, protein-protein interaction, post-translational modification, cell signaling, epigenetics S-nitrosylation, GAPDH, transnitrosylation, histone deacetylases, HDACs, nitric oxide, post-translational modification, protein modification, enzymatic activity, gene regulation, epigenetics, cellular signaling S-nitrosylated, GAPDH, transnitrosylation, histone deacetylases, physiological, NO signaling, post-translational modification, enzyme regulation, nitrosylation, epigenetic regulation S-nitrosylation, GAPDH, transnitrosylation, histone deacetylases, HDACs, nitric oxide signaling, enzyme modification, post-translational modification, protein-protein interaction, cell regulation S-nitrosylated GAPDH, transnitrosylation, histone deacetylases, HDACs, nitric oxide signaling, enzyme modification, post-translational modification, protein-protein interaction, cell signaling, epigenetic regulation
1180	The PRR MDA5 is a sensor of RNA virus infection. PRR, MDA5, sensor, RNA virus, infection, innate immunity, pattern recognition receptor, immune response, viral detection, RIG-I-like receptor, antiviral signaling PRR, MDA5, sensor, RNA virus, infection, pattern recognition receptor, innate immunity, antiviral response, immune system, viral recognition PRR, MDA5, sensor, RNA virus, infection, immune response, innate immunity, pattern recognition receptor, viral recognition, antiviral response, RIG-I-like receptor, innate immune sensing PRR, MDA5, sensor, RNA virus, infection, innate immunity, pattern recognition receptor, antiviral response, viral recognition, immune system PRR, MDA5, sensor, RNA virus, infection, innate immunity, pattern recognition receptor, viral detection, immune response, antiviral defense
198	CCL19 is absent within dLNs. CCL19, absent, dLNs, lymph nodes, chemokine, immune response, lymphoid tissues, chemokine expression, lymphoid chemokines, immune cell migration CCL19, absent, dLNs, lymph nodes, chemokine, immune response, lymphoid tissue, dendritic cells, chemokine signaling, lymphocyte recruitment CCL19, absence, dLNs, lymph nodes, chemokines, immune signaling, lymphocyte migration, lymphoid tissue, chemokine deficiency, immune microenvironment CCL19, absence, dLNs, lymph nodes, chemokine, immune response, lymphocyte migration, stromal cells, immune signaling, lymphoid tissue CCL19, dendritic lymph nodes, absence, chemokine, lymph nodes, immune response, lymphoid tissues, chemokine signaling, lymphocyte recruitment, lymph node stromal cells
870	Obesity decreases life quality. obesity, life quality, health, obesity effects, well-being, obesity health risks, quality of life, health outcomes, BMI, obesity impact Obesity, life quality, health, weight, wellness, chronic disease, physical health, mental health, BMI, obesity impacts, quality of life, health risks Obesity, life quality, health impact, weight management, obesity effects, quality of life, lifestyle, health risks, wellness, overweight, obesity complications obesity, life quality, health impacts, obesity effects, chronic disease, health risks, well-being, life expectancy, fitness, weight management obesity, life quality, health impact, obesity effects, quality of life, health risks, metabolic health, physical activity, mental health, chronic disease, weight management, health outcomes
993	Pyridostatin destabilizes the G - quadruplex in the telomeric region. Pyridostatin, G-quadruplex, telomeric region, DNA stabilization, quadruplex destabilization, telomeres, DNA structure, anticancer agents, nucleic acids, G-rich sequences Pyridostatin, G-quadruplex, telomeric region, DNA stabilization, quadruplex destabilization, G-quadruplex binding, telomeres, small molecules, DNA structure, cancer therapy Pyridostatin, G-quadruplex, telomeric DNA, DNA stabilization, quadruplex destabilization, telomeres, G4 structures, DNA binding, anticancer agents, genome stability Pyridostatin,G-quadruplex,Telomeric DNA,DNA stabilization,DNA destabilization,Nucleic acids,G4 structures,Telomeres,Small molecules,DNA interaction,Anticancer agents,Genomic stability Pyridostatin, G-quadruplex, telomeric region, DNA stabilization, quadruplex destabilization, telomeres, DNA secondary structures, anticancer agents, G-quadruplex interaction, telomere maintenance
873	Obesity is determined solely by environmental factors. Obesity, environmental factors, sole determination, genetics, lifestyle, diet, physical activity, obesity causes, environmental influence, health, obesity risk factors obesity, environmental factors, genetics, lifestyle, diet, physical activity, obesity determinants, health, obesity causes, environmental influences Obesity, environmental factors, determination, lifestyle, genetics, diet, physical activity, body weight, obesity causes, environmental influence obesity, environmental factors, genetics, lifestyle, diet, physical activity, metabolism, body mass index, hereditary, external influences Obesity, environmental factors, causes, genetics, lifestyle, diet, physical activity, genes, heritability, sedentary behavior, socioeconomic status, obesity determinants
1179	The PRR MDA5 has a central DExD/H RNA helices domain. PRR, MDA5, DExD/H, RNA helicases, domain, pattern recognition receptor, innate immunity, antiviral response, helicase domain, RIG-I-like receptors PRR, MDA5, DExD/H, RNA, helicase, domain, pattern recognition receptor, innate immunity, antiviral response, CARD, motif, pattern recognition, signaling, immune sensor PRR, MDA5, DExD/H, RNA helicase, domain, pattern recognition receptor, innate immunity, viral recognition, immune response, helicase domain, DExD/H box, RNA metabolism PRR, MDA5, DExD/H, RNA helicase, domain, pattern recognition receptor, innate immunity, antiviral response, helicase motif, signaling, immune sensing PRR, MDA5, DExD/H, RNA helices, domain, pattern recognition receptor, innate immunity, helicase, sensor, antiviral response
1298	Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke. graduated compression stockings, GCS, thigh-length, deep vein thrombosis, DVT, hospital patients, immobility, acute stroke, thrombosis prevention, compression therapy, venous thromboembolism, VTE, clinical trial, randomized controlled trial thigh-length, graduated compression stockings, GCS, deep vein thrombosis, DVT, hospital, immobile, acute stroke, prevention, efficacy, clinical trial thigh-length, graduated compression stockings, GCS, deep vein thrombosis, DVT, hospital, immobility, acute stroke, thromboprophylaxis, venous thromboembolism, VTE, efficacy, prevention, randomized controlled trial, RCT thigh-length, graduated compression stockings, GCS, deep vein thrombosis, DVT, hospital patients, immobility, acute stroke, thromboprophylaxis, compression therapy, venous thromboembolism, VTE, randomized controlled trial, RCT Thigh-length, graduated compression stockings, GCS, deep vein thrombosis, DVT, hospital, immobile, acute stroke, thromboprophylaxis, compression therapy, stroke patients, venous thromboembolism, VTE, randomized controlled trial, RCT
513	High cardiopulmonary fitness causes increased mortality rate. cardiopulmonary fitness, increased mortality, health outcomes, physical fitness, cardiovascular health, respiratory health, exercise, mortality risk, fitness levels, health risks cardiopulmonary fitness, mortality rate, exercise, physical activity, cardiovascular health, respiratory function, health outcomes, fitness levels, health risks cardiopulmonary fitness, mortality rate, exercise, cardiovascular health, lung capacity, physical activity, health outcomes, fitness levels, lifespan, disease risk cardiopulmonary fitness, high fitness, increased mortality, cardiovascular health, respiratory health, physical activity, exercise, cardiovascular risk, pulmonary function, health outcomes cardiopulmonary fitness, increased mortality, health outcomes, physical activity, cardiovascular health, respiratory health, fitness levels, disease risk, mortality factors, exercise, health research
514	High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter. calcium intake, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, dietary calcium, prevention, excess calcium, hyperparathyroidism, vitamin D sufficiency, calcium requirements calcium intake, secondary hyperparathyroidism, vitamin D levels, 25(OH)D, dietary calcium, prevention, unnecessary, hyperparathyroidism, vitamin D sufficiency, calcium requirements calcium intake, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, dietary calcium, hyperparathyroidism prevention, calcium requirements, vitamin D sufficiency, bone health, mineral metabolism calcium intake, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, dietary intake, prevention, bone health, parathyroid hormone, nutrient requirements, calcium supplementation dietary calcium, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, calcium intake, prevention, supplementation, serum calcium, parathyroid hormone, bone health, nutrient intake
756	Many proteins in human cells can be post-translationally modified at lysine residues via acetylation. proteins, human cells, post-translational modification, lysine residues, acetylation, cellular processes, protein regulation, enzyme activity, gene expression, epigenetics proteins, human cells, post-translational modification, lysine residues, acetylation, protein modification, cellular processes, enzyme activity, gene regulation, histone modification proteins, human cells, post-translational modification, lysine residues, acetylation, protein modification, cellular processes, enzyme activity, gene regulation, epigenetics proteins, human cells, post-translational modification, lysine residues, acetylation, protein modification, cellular processes, enzyme activity, gene regulation, histone modification proteins, human cells, post-translational modification, lysine residues, acetylation, protein modification, cellular processes, enzymatic modification, histone modification, gene regulation
636	Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate. Inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol 4-phosphate, signaling, enzyme, PI3K pathway, phosphoinositide metabolism Inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, 4-phosphate, phosphatase, enzyme, signaling, cell regulation Inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, conversion, enzymology, signaling, phosphoinositides Inositol lipid, 3-phosphatase, PTEN, PtdIns(3,4)P₂, phosphatidylinositol 4-phosphate, enzyme, phosphatidylinositol, lipid metabolism, signaling pathways, lipid conversion, phosphatase activity Inositol, lipid, 3-phosphatase, PTEN, PtdIns(3,4)P2, phosphatidylinositol, PI3P, phosphatase activity, signal transduction, lipid metabolism
516	High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD). CRP, chronic obstructive pulmonary disease, COPD, exacerbations, inflammation, biomarkers, immune response, disease progression, risk reduction, inflammatory markers CRP, chronic obstructive pulmonary disease, COPD, exacerbations, inflammation, biomarkers, risk reduction, high CRP, immune response, pulmonary health CRP, exacerbations, COPD, inflammation, biomarkers, risk reduction, chronic obstructive pulmonary disease, immune response, inflammation markers, disease progression CRP, C-reactive protein, COPD, chronic obstructive pulmonary disease, exacerbations, inflammation, immune response, biomarkers, respiratory health, disease progression CRP, chronic obstructive pulmonary disease, COPD, inflammation, exacerbations, risk factors, biomarkers, immune response, respiratory health, disease progression
637	Input from  mental and physical health care professionals is effective at decreasing homelessness. mental health, physical health, health professionals, homelessness, intervention, healthcare collaboration, support services, homelessness prevention, mental health services, physical health services, multidisciplinary approach, social services, healthcare strategies mental health, physical health, healthcare professionals, homelessness, intervention, support services, mental health care, physical health care, homelessness prevention, collaborative care, multidisciplinary approach, social services, housing support, health outcomes, public health mental health, physical health, health care professionals, homelessness, intervention, support, collaboration, multidisciplinary, prevention, treatment, service delivery, community health, social services, case management mental health, physical health, health care professionals, input, effectiveness, homelessness, homelessness prevention, healthcare collaboration, social services, mental health support, physical health support, interdisciplinary approach, homelessness intervention, healthcare strategies mental health, physical health, health care professionals, homelessness, intervention, collaboration, social services, multidisciplinary, prevention, treatment, housing support, mental health services, physical health services, client outcomes, healthcare collaboration
879	Occupancy of ribosomes by IncRNAs do not make functional peptides. ribosomes, IncRNAs, non-coding RNAs, peptides, translation, occupancy, functional, gene expression, RNA biology, ribosome profiling ribosomes, IncRNAs, occupancy, functional peptides, translation, non-coding RNAs, peptide synthesis, ribosomal binding, RNA function, gene expression Ribosomes, IncRNAs, occupancy, noncoding RNAs, functional peptides, translation, ribosome binding, RNA biology, gene expression, noncoding RNA functions ribosomes, IncRNAs, occupancy, functional peptides, translation, non-coding RNAs, ribosome binding, peptide synthesis, gene regulation, RNA function ribosomes, IncRNAs, occupancy, functional peptides, translation, non-coding RNAs, peptide synthesis, ribosome binding, gene regulation, RNA biology, translational activity
517	High levels of copeptin decrease risk of diabetes. copeptin, diabetes, risk factors, biomarker, vasopressin, metabolic health, hormonal regulation, glucose metabolism, epidemiology, biomarker accuracy copeptin, diabetes, risk, biomarkers, hormone, vasopressin, metabolic health, glucose regulation, prognostic indicator, endocrine, stress response copeptin, diabetes, risk factors, blood biomarkers, glucose metabolism, vasopressin, metabolic health, hormonal markers, disease prevention, biomarker research copeptin, diabetes, risk factors, biomarker, vasopressin, glucose regulation, metabolic health, hormone levels, cardiovascular risk, blood pressure copeptin, diabetes, risk factors, biomarker, high levels, metabolic health, vasopressin, insulin sensitivity, prognostic indicator, glucose regulation
759	Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission. Mathematical models, Artemisinin-based Combination Therapy, nongametocytocidal drugs, malaria transmission, drug efficacy, malaria, infectious Disease control, Plasmodium, epidemiology, treatment strategies Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, drug efficacy, malaria control, disease modeling, Plasmodium, antimalarial drugs, transmission reduction Mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, drug efficacy, malaria control, parasite clearance, transmission reduction, antimalarial drugs, disease modeling mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, drug efficacy, malaria control, infectious disease modeling, public health, malaria treatment strategies, transmission reduction mathematical models, Artemisinin-based combination therapy, nongametocytocidal drugs, malaria transmission, drug efficacy, malaria treatment, transmission reduction, malaria control, drug resistance, disease modeling
94	Albendazole is used to treat lymphatic filariasis. Albendazole, lymphatic filariasis, treatment, antiparasitic, medication, filaricidal, infectious disease, parasite, Wuchereria bancrofti, Brugia malayi Albendazole, lymphatic filariasis, treatment, antiparasitic, drug, helminthiasis, Wuchereria bancrofti, Brugia malayi, filarial worms, antifilarial, medication Albendazole, lymphatic filariasis, antiparasitic, helminthiasis, treatment, roundworm, Wuchereria bancrofti, Brugia malayi, filarial disease, drug therapy Albendazole, lymphatic filariasis, parasitic infections, antiparasitic drugs, tropical diseases, filarial worms, treatment, benzamidazole, Wuchereria bancrofti, Brugia malayi Albendazole, lymphatic filariasis, treatment, antiparasitic, Fasciola, Wuchereria bancrofti, Brugia malayi, microfilaricide, filarial infections
99	Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. Alizarin, hydrogen bonds, residues, PGAM1, substrate binding, protein-ligand interaction, enzyme active site, molecular docking, biochemical assay, structural analysis Alizarin, hydrogen bonds, residues, PGAM1, substrate binding, enzyme interaction, protein-ligand, molecular interaction, biochemical binding, active site, residues involving, substrate specificity Alizarin, hydrogen bonds, residues, PGAM1, substrate binding, enzyme, protein interaction, molecular docking, biochemical, structure Alizarin, hydrogen bonds, residues, PGAM1, substrate binding, enzyme, molecular interaction, protein, amino acids, binding site, ligand, catalysis, biochemical, structural biology Alizarin, hydrogen bonds, residues, PGAM1, substrate binding, protein-ligand interactions, enzyme active site, molecular interactions, biochemical, binding affinity
1197	The availability of safe places to study is not effective at decreasing homelessness. study environments, safe spaces, homelessness, shelter accessibility, educational resources, housing stability, public safety, social services, community support, policy impact study environments, safe spaces, homelessness, shelter options, educational access, public safety, housing insecurity, supportive services, resource accessibility, community programs study spaces, homelessness, safe environments, resource access, shelter availability, public safety, education facilities, urban planning, social services, housing stability study spaces, homelessness, safety, accessibility, shelter, youth, education, public spaces, housing, social services study, safe places, availability, homelessness, effectiveness, shelter, public spaces, education, housing, social services
1196	The availability of safe places to study is effective at decreasing homelessness. safe places, study locations, homelessness, shelter, education, safe environment, housing stability, academic space, support services, community resources study, safe places, homelessness, availability, escape, shelter, support services, education, housing, outreach study, safe places, availability, homelessness, decrease, housing, support, shelter, education, resource, underserved, community, access, mental health, stability study spaces, safe environments, homelessness prevention, accessible facilities, learning locations, support services, housing stability, educational support, community resources, shelter access safe places, study environments, homelessness prevention, shelter accessibility, educational spaces, social support, housing stability, community resources, public safety, urban planning
1194	The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'. arm density, TatAd complexes, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein complexes, structural biology, molecular mechanisms, protein interactions TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein complexes, conformational change, molecular interactions, complex architecture, protein structure TatAd complexes, arm density, structural rearrangements, charge zipper mechanism, Class1 complexes, protein-RNA interactions, conformational changes, molecular mechanism, complex stability, Tat system TatAd complexes, arm density, structural rearrangements, Class1 complexes, charge zipper mechanism, protein structure, molecular interactions, conformational changes, protein complexes, Tat pathway arm density, TatAd complexes, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein complexes, structural biology, molecular mechanisms, protein conformation, assembly dynamics
1191	The amount of publicly available DNA data doubles every 10 years. DNA data, public DNA datasets, genetic data growth, DNA database expansion, genome data proliferation, data growth rate, DNA sequence repositories, bioinformatics data, genomic information, data doubling trend DNA data, publicly available, data growth, genomic datasets, data doubling, bioinformatics, sequencing technology, data storage, data analysis, genetic information DNA data, public datasets, data growth, genomics, data doubling, data availability, bioinformatics, sequencing data, genetic repositories, data trends DNA data, publicly available, data growth, genome databases, genomic data, data doubling, DNA repositories, bioinformatics, data trends, sequencing data DNA data, publicly available, data growth, genetic databases, genome sequences, data doubling, data volume, sequencing data, genomic information, data trends
880	Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs ribosomes, IncRNAs, 5'-UTRs, occupancy, translation regulation, non-coding RNAs, mRNA translation, ribosome binding, gene expression, translational control, RNA-protein interactions ribosomes, IncRNAs, 5'-UTRs, occupancy, translation regulation, non-coding RNAs, mRNA, ribosome binding, translation initiation, gene expression, translational control ribosomes, IncRNAs, 5' UTRs, occupancy, translation regulation, non-coding RNAs, translational control, RNA interactions, ribosome binding, transcriptomics, gene expression ribosomes, IncRNAs, occupancy, 5' UTRs, translation regulation, non-coding RNAs, mRNA, ribosome binding, translation initiation, gene expression, RNA biology ribosomes, IncRNAs, 5' UTRs, occupancy, translation regulation, non-coding RNAs, mRNA translation, ribosome binding, untranslated regions, translational control
882	Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians. omnivores, vegetarians, trimethylamine N-oxide, dietary I-carnitine, TMAO, gut microbiota, meat consumption, plant-based diet, cardiovascular health, metabolic pathways Omnivores, vegetarian, trimethylamine N-oxide, dietary I-carnitine, gut microbiota, metabolism, diet, TMAO production, vegetarian diet, omnivorous diet, cardiovascular health, microbiome, nutrient absorption, dietary compounds Omnivores, vegetarians, trimethylamine N-oxide, TMAO, I-carnitine, diet, gut microbiota, metabolism, dietary intake, cardiovascular health Omnivores, vegetarians, trimethylamine N-oxide, I-carnitine, dietary intake, gut microbiota, metabolism, nutrition, cardiovascular health Omnivores, trimethylamine N-oxide, dietary I-carnitine, vegetarians, TMAO, gut microbiota, metabolism, diet, cardiovascular health, microbial conversion
641	Insomnia can be effectively treated with cognitive behavioral therapy. Insomnia, treatment, cognitive behavioral therapy, CBT, sleep disorders, sleep problems, therapy, sleep improvement, sleep therapy, insomnia remedies Insomnia, treatment, cognitive behavioral therapy, CBT, sleep disorders, sleep improvement, sleep therapy, insomnia management, behavioral therapy, sleep disruption, sleep hygiene insomnia, treatment, cognitive behavioral therapy, CBT, sleep disorders, sleep problems, sleeplessness, sleep therapy, sleep improvement, non-pharmacological, behavioral interventions Insomnia, sleep disorders, cognitive behavioral therapy, CBT, sleep treatment, sleep improvement, insomnia management, behavioral therapy, sleep problems, sleep issues, sleep therapy Insomnia, treatment, cognitive behavioral therapy, CBT, sleep disorders, sleep improvement, non-pharmacological, sleep therapy, behavioral interventions, sleep patterns
521	High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI). Cardiac troponin T, HSCT-T, dosage, diagnosis, symptom onset, ischemic injury, acute myocardial infarction, AMI, sensitivity, timing, biomarker, early detection high-sensitivity, cardiac troponin T, HSCT-T, dosage, diagnostic, symptom onset, less than 3 hours, acute myocardial injury, AMI, early detection, biomarker accuracy high-sensitivity, cardiac troponin T, HSCT-T, dosage, diagnostic, onset, symptoms, less than 3 hours, acute myocardial injury, AMI high-sensitivity, cardiac troponin T, HSCT-T, dosage, diagnostic, symptom onset, less than 3 hours, acute myocardial injury, AMI, biomarkers, early detection, myocardial infarction, sensitivity, specificity high-sensitivity, cardiac troponin T, HSCT-T, dosage, diagnostic, symptoms onset, less than 3 hours, acute myocardial injury, AMI
644	Insulin increases risk of severe kidney failure. Insulin, kidney failure, risk factors, nephropathy, diabetes, diabetic nephropathy, renal impairment, hyperglycemia, renal failure progression, insulin therapy Insulin, risk, severe, kidney, failure, diabetic nephropathy, renal impairment, hyperglycemia, diabetes, kidney function, adverse effects, nephrology Insulin, risk, severe, kidney failure, nephropathy, diabetes, diabetic nephropathy, renal failure, hyperglycemia, glucose control, kidney damage, diabetic complications Insulin, kidney failure, renal impairment, diabetes complications, nephropathy, hyperglycemia, diabetic nephropathy, renal risk factors, insulin therapy, kidney function decline Insulin, risk, severe, kidney failure, nephropathy, diabetes, diabetic nephropathy, renal impairment, hypoglycemia, renal function deterioration, long-term effects
887	Only a minority of cells survive development after differentiation into stress-resistant spores. cell survival, development, differentiation, stress-resistant spores, minority, viability, spore formation, resistance, cellular differentiation, survival rate cell survival, development, differentiation, stress-resistant spores, minority, spore formation, cell viability, stress tolerance, developmental biology, bacterial spores cells, survival, development, differentiation, stress-resistant, spores, minority cells, survival, development, differentiation, stress-resistant spores, minority, viability, spore formation, cellular resilience, stress response cell survival, development, differentiation, stress-resistant spores, minority, spore formation, cell fate, stress response
525	Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors. histone demethylase, recruitment, histone methylation, transient decrease, ligand-dependent, transcription, nuclear receptors, epigenetics, gene expression, chromatin modifications Histone demethylase, recruitment, histone methylation, methylation decrease, ligand-dependent transcription, nuclear receptors, chromatin modification, gene expression, epigenetics, transcription regulation histone demethylase, recruitment, histone methylation, ligand-dependent, transcription, nuclear receptors, epigenetics, gene regulation, chromatin modification, transient decrease histone demethylase, recruitment, histone methylation, transient decrease, ligand-dependent, transcription induction, nuclear receptors, epigenetics, chromatin modification, gene regulation histone demethylase, recruitment, histone methylation, transient decrease, ligand-dependent transcription, nuclear receptors, gene expression, epigenetics, chromatin modification, transcription regulation
768	Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT). Mercaptopurine, anabolized, methylmercaptopurine, inactive, thiopurine methyltransferase, TPMT, metabolic pathway, drug metabolism, enzyme activity, pharmacogenetics Mercaptopurine, anabolism, methylmercaptopurine, inactive, thiopurine methyltransferase, TPMT, drug metabolism, enzymatic reaction, pharmacogenetics, enzyme activity Mercaptopurine, anabolism, methylmercaptopurine, thiopurine methyltransferase, TPMT, drug metabolism, inactive metabolites, enzymatic conversion, pharmacogenetics, therapeutic drugs, chemotherapeutic agents Mercaptopurine, anabolism, methylmercaptopurine, inactivation, thiopurine methyltransferase, TPMT, metabolism, enzymatic pathway, drug metabolism, methylation Mercaptopurine, anabolism, methylmercaptopurine, inactive, TPMT, thiopurine methyltransferase, metabolism, biotransformation, drug metabolism, enzyme activity
527	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress. Homozygous deletion, murine Sbds gene, Osterix-expressing cells, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene knockout, skeletal stem cells, oxidative damage, bone biology, gene function, mesenchymal lineage, genetic modification Homozygous deletion, murine Sbds gene, osterix-expressing cells, mesenchymal stem cells, progenitor cells, oxidative stress, gene knockout, Sbds deficiency, skeletal development, MSCs, oxidative damage Homozygous deletion, Sbds gene, murine, Osterix, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene knockout, muscle, bone, differentiation, cellular stress, stem cell biology, gene function, oxidative damage Homozygous deletion, murine Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene deletion, skeletal stem cells, osteoblast differentiation, oxidative damage, cellular stress, Sbds function, gene knockout, skeletal biology Homozygous deletion, murine Sbds gene, osterix-expressing, mesenchymal stem cells, MPCs, oxidative stress, gene knockout, skeletal development, stem cell biology, oxidative damage, cellular redox, mesenchymal progenitors, bone regeneration, gene function, oxidative injury
528	Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax. Human T-lymphotropic virus, HAM/TSP, tropical spastic paraparesis, IgG antibodies, cross-reactivity, immunodominant epitope, Tax, neuroinflammation, autoimmune response, T-cell response, viral epitopes, neurodegeneration, retrovirus, HTLV-I, immune response Human T-lymphotropic virus, HTLV-I, HAM/TSP, tropical spastic paraparesis, IgG antibodies, immunodominant epitope, Tax protein, cross-reactivity, neuroimmunology, viral antigens, autoimmune response, neurodegenerative diseases Human T-lymphotropic virus, HAM/TSP, tropical spastic paraparesis, IgG antibodies, immunoglobulin G, cross-reactivity, immunodominant epitope, Tax protein, T-cell response, neuroinflammation, viral antigens, autoimmune response, neurological disorder Human T-lymphotropic virus, HTLV-I, HAM/TSP, tropical spastic paraparesis, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, neuroimmunology, viral antigen, autoimmune response, infectious disease, neurological disorder HAM/TSP, Human T-lymphotropic virus, HTLV-I, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, T-cell response, neurological disorder, spastic paraparesis, viral neuroinvasion, autoimmune response, antibody profiling, viral latency
649	Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance collaborative learning, classroom-based, Web-based, integration, digital education, online learning, collaborative tools, class performance, learning outcomes, educational technology, blended learning, e-learning, group work, student engagement, teaching methods collaborative learning, classroom-based, web-based, integration, performance, educational technology, collaborative methods, virtual learning, face-to-face, online collaboration, learning outcomes, instructional strategies, blended learning, student engagement collaborative learning, classroom-based, web-based, integration, learning performance, educational technology, blended learning, online collaboration, classroom collaboration, learning outcomes, digital learning, instructional strategies, student engagement, instructional technology collaborative learning, classroom-based, web-based, integration, performance, educational technology, online learning, collaborative methodologies, student engagement, learning outcomes collaborative learning, classroom-based, web-based, integration, educational technology, student performance, online learning, collaborative strategies, instructional design, e-learning, digital collaboration, academic achievement
1088	Silencing of Bcl2 is important for the maintenance and progression of tumors. Bcl2, silencing, tumors, cancer, gene regulation, apoptosis, tumor progression, oncogenes, tumor suppressors, cell death, gene silencing, cancer therapy Bcl2, gene silencing, tumor progression, cancer, apoptosis, anti-apoptotic, cell survival, tumor maintenance, gene expression, oncogenesis Bcl2, gene silencing, tumor progression, cancer, apoptosis, oncogenesis, gene regulation, tumor growth, apoptosis inhibition, therapy targets Bcl2, gene silencing, tumor progression, cancer, apoptosis, cell survival, gene regulation, oncogenesis, tumor maintenance, molecular mechanisms Bcl2, silencing, tumor, cancer, apoptosis, gene regulation, tumor progression, cell death, oncogenesis, gene expression, therapy, molecular mechanism
1086	Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, male libido, sexual performance, serotonin reuptake inhibitors, treatment, sexual health Sildenafil, erectile function, sexual dysfunction, SSRIs, antidepressants, sexual performance, medication, treatment, efficacy, drug interactions Sildenafil, erectile dysfunction, SSRI antidepressants, sexual dysfunction, male sexual health, sexual side effects, antidepressant-induced sexual dysfunction, treatment, erectile function, pharmacology Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, male sexual health, treatment, medication, sexual side effects, sexual performance Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, male sexual health, treatment, sexual side effects, serotonin reuptake inhibitors, pharmacology
770	Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, elderly patients, oxaliplatin, chemotherapy, treatment outcomes, comparison, single agent, adverse effects metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, oxaliplatin, chemotherapy, elderly patients, treatment comparison metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, elderly patients, oxaliplatin, chemotherapy, treatment outcomes, drug comparison, adverse effects Metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, elderly, oxaliplatin, chemotherapy, treatment comparison, single agent, reduced effectiveness metastatic colorectal cancer, fluoropyrimidines, efficacy, quality of life, oxaliplatin, chemotherapy, elderly patients, treatment outcomes, single agent, combination therapy, adverse effects
410	Febrile seizures increase the threshold for development of epilepsy. febrile seizures, epilepsy, seizure threshold, febrile illness, seizure risk, neurological development, pediatric neurology, seizure prevention, epilepsy risk factors, febrile condition, seizure mechanisms febrile seizures, epilepsy, seizure threshold, febrile, neurological disorders, seizure development, neurobiology, risk factors, pediatric seizures, hyperthermia, epilepsy prevention, neurological threshold, febrile illness, seizure progression febrile seizures, epilepsy, seizure threshold, febrile illness, neurologic development, pediatric seizures, seizure progression, neurological disorders, febrile illness, seizure risk factors febrile seizures, epilepsy, seizure threshold, increase, development, febrile illness, neurological, pediatric, risk factors, neurodevelopment febrile seizures, epilepsy, seizure threshold, febrile illness, neurological disorders, seizure risk, pediatric seizures, fever-related seizures, epilepsy development, neurological threshold
411	Febrile seizures reduce the threshold for development of epilepsy. febrile seizures, epilepsy, seizure threshold, febrile illness, neurological development, seizure risk, pediatric neurology, febrile convulsions, epileptogenesis, fever-induced seizures febrile seizures, epilepsy, seizure threshold, neurodevelopment, pediatric neurology, febrile illness, seizure management, epilepsy risk factors, neurological development, pediatric epilepsy febrile seizures, seizure threshold, epilepsy development, febrile illness, neuronal excitability, seizure progression, pediatric epilepsy, neurological disorder, febrile convulsions, epilepsy risk factors febrile seizures, epilepsy, seizure threshold, febrile illness, neurological disorder, epileptogenesis, pediatric seizures, risk factors, neurological development, febrile episode febrile seizures, epilepsy, seizure threshold, febrile illness, neurological development, seizure risk, pediatric epilepsy, febrile episode, neurological threshold, seizure precipitants
532	Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis. Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood clot, coagulation, peripheral artery disease, graft failure, thrombosis risk, hemostasis Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood coagulation, clot formation, peripheral artery disease, graft patency, hemostasis, thrombogenic factors Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, blood clot, vascular surgery, peripheral artery disease, thrombotic risk, fibrinogen levels, graft failure, arterial occlusion Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, blood viscosity, clotting factors, venous thromboembolism, arterial thrombosis, graft failure, ischemia, vascular surgery, coagulation disorders Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, thrombosis risk, fibrinogen levels, arterial bypass, peripheral artery disease, graft occlusion, blood coagulation, thrombosis prevention
533	Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis. Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood clotting, circulation, arterial disease, graft failure, coagulation factors, peripheral artery disease Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood clot, coagulation, elevated fibrinogen, arterial occlusion, graft failure, peripheral artery disease hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, blood coagulation, clot formation, arterial occlusion, bypass graft failure, thrombotic risk, hemostasis, peripheral artery disease Hyperfibrinogenemia, femoropopliteal, bypass, thrombosis, vascular, occlusion, blood clot, circulation, peripheral artery disease, surgical outcomes Hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vein graft failure, blood coagulation, clot formation, vascular surgery, postoperative complications, thrombotic risk, fibrinogen levels
775	Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR). mice, DNA polymerase I, polI, genetic deficiency, DNA repair, ionizing radiation, IR sensitivity, DNA damage, mutation, radiosensitivity, gene mutation, genome stability, DNA replication mice, DNA polymerase I, polI, DNA repair, ionizing radiation, IR sensitivity, genetics, mutant mice, DNA damage, DNA replication, DNA synthesis, radiobiology mice, DNA polymerase I, polI, DNA repair, ionizing radiation, IR sensitivity, genetic defect, DNA damage, repair mechanisms, radiation sensitivity mice, DNA polymerase I, polI, genetic defect, DNA repair, ionizing radiation, IR sensitivity, genomic instability, mutation, DNA damage response mice, DNA polymerase I, polI, DNA repair, ionizing radiation, IR sensitivity, genetic mutations, radiation sensitivity, DNA damage, homologous recombination, non-homologous end joining, genomic instability
1199	The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins. colchicine, secondary prevention, high-dose statins, cardiovascular therapy, anti-inflammatory, atherosclerosis, myocardial infarction, stroke, lipid management, cardiovascular risk reduction colchicine, benefits, secondary prevention, strategies, high-dose statins, cardiovascular disease, anti-inflammatory, lipid-lowering, atherosclerosis, cardiovascular protection colchicine, benefits, secondary prevention, strategies, high-dose statins, cardiovascular, treatment, anti-inflammatory, therapy, prevention colchicine, benefits, secondary prevention, high-dose statins, cardiovascular, treatment, efficacy, usage, lipid management, anti-inflammatory, medication, heart disease colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, anti-inflammatory therapy, lipid management, medication effectiveness, cardiovascular risk reduction
535	Hypertension is frequently observed in type 1 diabetes patients. Hypertension, type 1 diabetes, blood pressure, cardiovascular risk, comorbidities, prevalence, management, complications, diabetic patients, risk factors hypertension, type 1 diabetes, prevalence, cardiovascular risk, blood pressure, diabetic complications, comorbidities, epidemiology, management hypertension, high blood pressure, type 1 diabetes, diabetes complications, cardiovascular risk, blood pressure management, diabetic complications, comorbidities, insulin dependence, vascular health hypertension, type 1 diabetes, high blood pressure, diabetes complications, cardiovascular risk, diabetic nephropathy, blood pressure monitoring, insulin therapy, microvascular complications, diabetic management hypertension, type 1 diabetes, prevalence, comorbidity, blood pressure, cardiovascular risk, diabetic complications, epidemiology
415	Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia. female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia, neurodegeneration, genetics, Alzheimer's disease, cognitive decline female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia, neurodegenerative, genetic risk, Alzheimer's disease, cognitive decline Apolipoprotein E4, APOE4, female carriers, dementia risk, genetic risk factors, Alzheimer's disease, APOE genotype, neurodegeneration, cognitive decline, genetic predisposition Apolipoprotein E4, APOE4, female, women, carriers, genetic risk, dementia, Alzheimer's disease, neurodegeneration, aging, risk factors, genetics, neurobiology, mental decline, cognitive impairment female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia, Alzheimer's disease, genetic predisposition, neurodegeneration, cognitive decline
536	Hypocretin neurones induce panicprone state in rats. hypocretin, orexin, neurons, panic, anxiety, rats, fear, neural circuits, stress, hypothalamus, neurotransmitters, behavioral responses Hypocretin, Orexin, Neurons, Panic, Anxiety, Rats, Fear, Neural circuitry, Neurotransmitters, Stress response, Hypothalamus, Behavioral studies, Neurophysiology, Emotional regulation Hypocretin,neurons,panic,anxiety,rats,behavior,neurotransmitter,arousal,stress,brain,signal,neurophysiology,panic disorder,hippocampus,amygdala,sleep,wakefulness,cortical activity Hypocretin,neurons,panic,anxiety,rats,neurotransmitters,sleep,alertness,behavior,brain,orexin,hyperarousal,investigation,stress,neurobiology Hypocretin, orexin, neurones, neurons, induce, induce, panic, panic disorder, anxiety, rat, rats, stress, arousal, neurobiology, fear, behavior, hypothalamus
659	Ivermectin is used to treat lymphatic filariasis. Ivermectin, lymphatic filariasis, treatment, antiparasitic, neglected tropical disease, filarial worms, microfilaricidal, parasitic infections, drug efficacy Ivermectin, lymphatic filariasis, treatment, antiparasitic drugs, Wolbachia, microfilaricide, filariasis management, tropical diseases, parasite eradication, public health Ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial worms, tropical disease, disease management, mass drug administration, onchocerciasis, strongyloidiasis Ivermectin, lymphatic filariasis, treatment, antiparasitic, medication, tropical disease, worm infection, filarial nematodes, mass drug administration, disease management Ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial worms, tropical diseases, onchocerciasis, vector-borne diseases, microfilaricide, filarial infection
539	Hypoglycemia increases the risk of dementia. hypoglycemia, dementia, cognitive decline, blood sugar, neurodegeneration, hypoglycemia risk, glucose levels, aging, neurological health, diabetes, insulin, brain health hypoglycemia, dementia, cognitive decline, blood sugar, neurodegeneration, insulin resistance, glucose metabolism, brain health, hypoglycemia risks, neurological disorders hypoglycemia, dementia, cognitive decline, blood sugar, hypoglycemic episodes, neurological risk, insulin, diabetes, brain health, neurodegeneration Hypoglycemia, dementia, cognitive decline, blood sugar, neurological risk, hypoglycemia effects, memory impairment, glucose levels, elderly, neurodegeneration hypoglycemia, dementia, cognitive decline, blood sugar, neurodegeneration, hypoglycemia risks, diabetes complications, brain health, hypoglycemia and cognition, neurological disorders
1099	Statins decrease blood cholesterol. Statins, cholesterol, blood, lipid-lowering, cardiovascular, LDL, HDL, triglycerides, medication, therapy Statins, blood cholesterol, decrease, lipid-lowering, HMG-CoA reductase inhibitors, cardiovascular health, cholesterol reduction, hyperlipidemia, medication, therapy statins, blood cholesterol, decrease, lipid-lowering, hyperlipidemia, cardiovascular health, statin therapy, LDL reduction, statin medications, cholesterol management statins, blood cholesterol, lipid-lowering, HDL, LDL, cardiovascular health, triglycerides, cholesterol reduction, statin therapy, hyperlipidemia statins, blood cholesterol, lipid-lowering, cardiovascular health, hyperlipidemia, cholesterol reduction, HMG-CoA reductase inhibitors, cardiovascular disease prevention
660	Ivermectin is used to treat onchocerciasis. Ivermectin, treat, onchocerciasis, antiparasitic, parasite, infection, nematode, Onchocerca, skin, river blindness, treatment, medication Ivermectin, onchocerciasis, treatment, antiparasitic, nematode, infectious disease, microfilaricide, river blindness, Onchocerca, drug therapy Ivermectin, onchocerciasis, treatment, antiparasitic, filarial, Onchocerca, skin, microfilariae, river blindness, medication Ivermectin, onchocerciasis, treatment, antiparasitic, river blindness, nematode infection, microfilaricide, Onchocerca volvulus, drug, antiparasitic agents Ivermectin, onchocerciasis, treatment, antiparasitic, skin disease, microfilaricide, Onchocerca volvulus, river blindness, medical use, pharmacology
781	Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis. Mice, Interferon-γ, IFN-γ, receptor, immune response, autoimmune myocarditis, resistance, experimental, immunity, cytokines, immunology, cardiac inflammation Mice, Interferon-γ, IFN-γ, receptor, knockout, resistance, experimental autoimmune myocarditis, myocarditis, autoimmune, immune response, cytokines, immunology, inflammation, cardiac, heart, immune regulation Mice, Interferon-γ, IFN-γ, receptor, autoimmune myocarditis, resistance, immunity, immunology, inflammation, cardiology, experimental model, cytokines, immune response Mice, Interferon-γ, Interferon receptor, autoimmune myocarditis, resistance, immune response, cytokines, inflammation, experimental model mice, Interferon-γ, IFN-γ receptor, immune response, autoimmune myocarditis, disease resistance, immunology, cytokines, inflammation, experimental model
540	Hypothalamic glutamate neurotransmission is crucial to energy balance. hypothalamus, glutamate, neurotransmission, energy balance, neurochemistry, hunger regulation, appetite control, central nervous system, metabolic regulation, hypothalamic signaling hypothalamus, glutamate, neurotransmission, energy balance, neural communication, hypothalamic regulation, metabolic signaling, excitatory neurotransmitters, energy homeostasis, neurobiology hypothalamus, glutamate, neurotransmission, energy balance, neurochemistry, metabolic regulation, hypothalamic signaling, amino acids, neural pathways, appetite control hypothalamus, glutamate, neurotransmission, energy balance, neuronal signaling, hypothalamic regulation, metabolic control, amino acids, neurochemical pathways, energy homeostasis hypothalamus, glutamate, neurotransmission, energy balance, neurobiology, neural signaling, hypothalamic regulation, metabolic control, neurotransmitter, energy homeostasis
783	Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA. mice, IFN-γ, interferon-gamma, receptor, immune response, EAM, experimental autoimmune myocarditis, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, autoimmunity, cardiac inflammation, immune deficiency, cytokines, cardiac disease, mouse model mice, IFN-γ, interferon gamma, receptor, resistance, EAM, experimental autoimmune myocarditis, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, autoimmune, cardiac, immunity mice, IFN-γ, interferon gamma, receptor, resistance, EAM, experimental autoimmune myocarditis, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, autoimmune, cardiac, inflammation, immune response mice, IFN-γ, interferon gamma, receptor, resistance, EAM, experimental autoimmune myocarditis, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, autoimmunity, immune response, cardiac inflammation mice, IFN-γ, interferon gamma, receptor, resistance, EAM, experimental autoimmune myocarditis, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, immunology, autoimmunity
300	Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake. cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, iron regulation, post-transcriptional regulation, iron metabolism, mRNA binding cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, iron regulation, post-transcriptional regulation, RNA-binding proteins, iron homeostasis, mRNA stability cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, iron regulation, gene expression, iron metabolism, mRNA stability cytosolic proteins, iron-responsive elements, mRNA, DMT1, iron uptake, protein binding, iron regulation, mRNA stability, iron homeostasis, iron metabolism cytosolic proteins, iron-responsive elements, mRNAs, DMT1, iron uptake, protein binding, iron regulation, post-transcriptional control, iron homeostasis, mRNA translation
421	Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules. flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, tumor, microenvironment, drug delivery, molecular interactions flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, tumor biology, drug delivery, cellular interactions, microenvironment factors flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, tumor biology, microenvironment, molecular interactions, drug delivery, bioavailability flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, tumor biology, molecule interactions, microenvironment effects, drug delivery, molecular conformation flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, microenvironment impact, molecular interactions, tumor biology, drug delivery, molecular conformations
784	MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis microRNA, neural stem cells, NSC, differentiation, proliferation, homeostasis, gene regulation, neurogenesis, stem cell biology, molecular pathways, cellular signaling, neural development, gene expression MicroRNA, Neural Stem Cells, NSC, differentiation, proliferation, homeostasis, gene regulation, stem cell biology, neurogenesis, molecular mechanisms, cell cycle, signaling pathways microRNA, neural stem cells, NSC, differentiation, proliferation, homeostasis, gene regulation, neurogenesis, stem cell biology, RNA interference, cell cycle, neural development, molecular biology MicroRNA, neural stem cells, NSC, differentiation, proliferation, homeostasis, gene regulation, stem cell biology, neurogenesis, molecular biology, RNA regulation MicroRNA, neural stem cells, NSC, differentiation, proliferation, homeostasis, gene regulation, neurogenesis, stem cell biology, molecular biology
785	Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures. microarray, results, culture-amplified, mixtures, serotypes, correlation, uncultured, comparison, amplification, detection, bacterial, diversity, assay, precision microarray, results, culture-amplified, mixtures, serotypes, correlation, uncultured, comparison, amplification, diversity, detection, accuracy, sensitivity, specificity microarray, culture, amplification, serotypes, correlation, uncultured, mixtures, results, comparison, sensitivity microarray, culture-amplified, serotypes, uncultured, mixture, correlation, results, amplification, detection, bacterial, genetic, amplification bias, sample preparation, diagnostic accuracy microarray, results, culture, amplified, mixtures, serotypes, correlation, uncultured, detection, accuracy, comparison, diagnostics, amplification, microbes, microbial, heterogeneity
544	IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs. IFIT1, viral replication, sequestration, mis-capped viral RNAs, immune response, antiviral defense, interferon-stimulated genes, RNA recognition, viral RNA, innate immunity IFIT1, viral replication, sequestration, mis-capped viral RNAs, antiviral response, innate immunity, RNA recognition, interferon-stimulated genes, immune defense, viral RNA sensing IFIT1, viral replication, sequestration, mis-capped viral RNAs, antiviral response, innate immunity, interferon-stimulated genes, host defense, RNA cap modification, immune recognition IFIT1, viral replication, mis-capped viral RNAs, RNA sequestration, antiviral defense, innate immunity, interferon response, RNA cap modification, host-virus interaction, immune restriction IFIT1, viral replication, sequestration, mis-capped RNAs, antiviral response, immune defense, RNA recognition, viral RNA, immune evasion, host defense
303	DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region. DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene regulation, sex determination, epigenetics, gene expression, chromatin modification, genetic regulation DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene regulation, sex determination, epigenetics, gene expression, molecular genetics, genetic regulation DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene regulation, epigenetics, sex determination, gene expression, genetic regulation, epigenetic mechanisms DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, sex differentiation, epigenetics, genetic regulation, chromosome, avian genetics DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, sex differentiation, epigenetics, gene regulation, sex chromosomes, genetic mechanisms
1089	Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. Smc5/6, engagement, activation, SUMO E3 ligase, Mms21, ATP-dependent, remodeling, protein modification, ubiquitination, DNA repair, chromatin, sumoylation, protein complexes Smc5/6, engagement, activation, SUMO E3 ligase, Mms21, ATP-dependent, remodeling Smc5/6, engagement, activation, SUMO E3 ligase, Mms21, ATP-dependent, remodeling, protein modification, DNA repair, chromatin, ubiquitin-like proteins Smc5/6, activation, SUMO E3 ligase, Mms21, ATP, remodeling, engagement, protein modification, DNA repair, chromosomal stability Smc5/6, SUMO, E3 ligase, Mms21, ATP-dependent, remodeling, chromatin, DNA repair, SUMOylation, protein modification, genome stability
549	IRG1 has antiviral effects against neurotropic viruses. IRG1, antiviral, neurotropic viruses, immune response, antiviral mechanisms, neuroinvasion, viral inhibition, neuroimmunity, innate immunity, neurotropic pathogen, host defense, immune regulation IRG1, antiviral, neurotropic viruses, immune response, neuroinflammation, gene expression, virus defense, host immunity, neuroprotection, innate immunity IRG1, antiviral, neurotropic viruses, immune response, viral inhibition, neuroinvasion, neurotropic, innate immunity, neurodegeneration, antiviral mechanisms IRG1, antiviral, neurotropic viruses, immune response, neuroinflammation, viral replication, innate immunity, antiviral mechanisms, neurovirology, host defense IRG1, antiviral, neurotropic viruses, immune response, viral inhibition, neuroinvasion, innate immunity, immune signaling, neuroprotection, antiviral mechanisms
551	ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). ITAM, phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, immune signaling, T cell activation, immune response ITAM, phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, immune signaling ITAM, phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, immune signaling ITAM, phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, immune signaling, T cell activation, receptor signaling ITAM, phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, immune signaling, T cell activation, receptor signaling, immunology
793	Mitochondria are uninvolved in apoptosis. mitochondria, apoptosis, cell death, mitochondrial function, apoptosis mechanisms, apoptosis pathways, mitochondrial role, cell biology, apoptosis regulation Mitochondria, apoptosis, uninvolved, cell death, organelles, intrinsic pathway, cytochrome c, caspases, mitochondrial membrane potential, apoptosis regulation mitochondria, apoptosis, cell death, mitochondrial function, apoptosis pathways, mitochondria role, programmed cell death, cellular processes, apoptosis mechanisms mitochondria, apoptosis, uninvolved, cell death, mitochondrial functions, apoptosis pathways, mitochondria role, apoptosis mechanisms, cell biology, apoptosis process mitochondria, apoptosis, uninvolved, cell death, mitochondrial function, apoptosis pathways, cellular processes, apoptosis regulation, mitochondrial role
431	FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS). FoxO3a, neuronal death, reactive oxygen species, ROS, activation, oxidative stress, apoptosis, neurodegeneration, signaling pathway, transcription factors FoxO3a, neuronal death, reactive oxygen species, ROS, activation, neurodegeneration, apoptosis, oxidative stress, transcription factors, cell signaling FoxO3a, neuronal death, reactive oxygen species, ROS, activation, neurodegeneration, oxidative stress, apoptosis, signaling pathways, transcription factors FoxO3a, neuronal death, reactive oxygen species, ROS, activation, neurodegeneration, oxidative stress, apoptosis, signaling pathway, oxidative damage FoxO3a, neuronal death, reactive oxygen species, ROS, activation, apoptosis, oxidative stress, neurodegeneration, signaling pathways, transcription factors, cell death, oxidative damage
552	IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet. IgA, plasma cells, transglutaminase 2, accumulation, duodenal mucosa, gluten-free diet, celiac disease, immune response, intestinal immunity, mucosal immunology IgA, plasma cells, transglutaminase 2, gluten-free diet, duodenal mucosa, autoimmune response, celiac disease, antibody production, gastrointestinal immunology, mucosal immunity IgA plasma cells, transglutaminase 2, gluten-free diet, duodenal mucosa, celiac disease, immune response, antibody production, intestinal lining, tissue-specific, autoimmune, gluten sensitivity IgA, plasma cells, transglutaminase 2, accumulation, duodenal mucosa, gluten-free diet, celiac disease, immune response, mucosal immunity, antibody production IgA, plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, immune response, antibody production, intestinal inflammation, mucosal immunity
674	LDL cholesterol has no involvement in the development of cardiovascular disease. LDL cholesterol, cardiovascular disease, involvement, development, lipid, atherosclerosis, risk factors, blood lipids, cholesterol levels, heart disease LDL cholesterol, cardiovascular disease, atherosclerosis, lipid profile, heart disease, low-density lipoprotein, risk factors, cholesterol, lipid metabolism, cardiovascular risk LDL, low-density lipoprotein, cholesterol, cardiovascular disease, CVD, atherosclerosis, lipid profile, heart health, blood lipids, risk factors LDL, low-density lipoprotein, cholesterol, cardiovascular disease, CVD, atherosclerosis, lipid profile, heart health, risk factors, cholesterol levels LDL, low-density lipoprotein, cholesterol, cardiovascular disease, CVD, risk factors, lipid profile, atherosclerosis, arterial plaque, heart disease, vessel health, lipid metabolism
312	De novo assembly of sequence data has more specific contigs than unassembled sequence data. de novo assembly, sequence data, contigs, unassembled data, genome assembly, sequence assembly, bioinformatics, genomic contigs, sequence analysis, computational biology de novo assembly, sequence data, contigs, unassembled data, genome assembly, sequence alignment, bioinformatics, genomic contigs, sequencing technologies, data assembly, sequence analysis de novo assembly, sequence data, contigs, unassembled data, genome assembly, sequence analysis, bioinformatics, assembly algorithms, contig length, assembly quality de novo assembly, sequence data, contigs, unassembled data, genome assembly, sequence contigs, bioinformatics, genome sequencing, sequence analysis, data assembly de novo assembly, sequence data, contigs, unassembled data, genome assembly, bioinformatics, sequence analysis, contig length, assembly accuracy, data quality
554	Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1. immune complex, cell death, extracellular release, neutrophil, HMGB1, immune response, inflammation, autoimmunity, neutrophil protein, immune complex-mediated, immune activation, cytokines, tissue damage immune complex, cell death, neutrophil, HMGB1, extracellular release, immune response, inflammation, apoptosis, necrosis, autoimmune disease, immune activation, cytokine release, neutrophil degranulation immune complex, cell death, extracellular release, neutrophil, HMGB1, inflammation, immune response, immune activation, neutrophil proteins, tissue damage immune complex, cell death, neutrophil, extracellular release, HMGB1, inflammation, immune response, immune activation, neutrophil protein, immune system immune complex, cell death, neutrophil, HMGB1, extracellular release, inflammation, immune response, apoptosis, necrosis, immune signaling
314	Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome. deamination, cytidine, uridine, viral DNA, minus strand, G-to-A mutations, viral genome, mutations, nucleotide modifications, DNA editing, mutagenesis deamination, cytidine, uridine, viral DNA, minus strand, G-to-A mutations, viral genome, mutation, nucleotide editing, antiviral defense, mutagenesis, viral replication Deamination, cytidine, uridine, viral DNA, minus strand, G-to-A mutations, genome editing, mutation, mutagenesis, viral replication, nucleotide modification deamination, cytidine, uridine, viral DNA, minus strand, G-to-A mutations, mutation mechanism, viral genome, nucleotide editing, mutagenesis Deamination, cytidine, uridine, viral DNA, minus strand, G-to-A mutations, mutations, viral genome, DNA editing, mutagenesis, nucleotide mutation, mutation mechanism
436	Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated. histones, degradation, Rad53, DNA replication, chromatin, protein degradation, DNA damage response, post-replication, histone turnover, cell cycle histones, degradation, Rad53, DNA replication, chromatin, histone turnover, post-replication, cellular response, DNA damage, chromatin remodeling histones, degradation, Rad53, DNA replication, chromatin, histone turnover, DNA damage response, cell cycle, post-replication, protein degradation histones, Rad53, degradation, DNA replication, chromatin, histone turnover, DNA damage response, protein phosphorylation, chromatin remodeling, cell cycle, checkpoint kinases histones, degradation, Rad53, DNA replication, chromatin remodeling, histone clearance, DNA damage response, post-replication, protein degradation, replication checkpoint
437	Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model. Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, hematologic disorders, genetic mutations, disease mechanisms, research models, hematopoiesis, chromosomal abnormalities Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, disease mechanisms, hematological disorder, genetic mutations, bone marrow, hematopoiesis, leukemogenesis, preclinical models, genomic instability, transcriptional regulation, epigenetics Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, molecular mechanisms, genetic mutations, hematological disorders, disease pathogenesis, model organisms, gene function, preclinical studies Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, hematopoietic stem cells, chromosomal abnormalities, gene mutations, disease modeling, pathogenesis, bone marrow failure, preclinical studies, mouse models, translational research Myelodysplastic syndrome, MDS, genomic alterations, genetic mutations, functional consequences, animal model, pathogenesis, hematopoiesis, genome instability, chromosomal abnormalities, preclinical models, marrow failure, disease progression, gene expression, molecular mechanisms
439	Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation Fz, PCP, planar cell polarity, Pk, localization, anterior membrane, neuroectoderm, zebrafish, neuralation, cell polarity, embryonic development, signaling pathways Fz, PCP, planar cell polarity, Pk, polarization, neuroectoderm, zebrafish, neuralation, anterior membrane, cell localization Fz, PCP, planar cell polarity, Pk, neuroectoderm, zebrafish, neuralation, anterior membrane, cell localization, embryonic development Fz, PCP, polarity, neuroectoderm, zebrafish, neuralation, anterior membrane, cell localization, signaling pathways, gastrulation, embryogenesis, cell polarity, planar cell polarity Fz, PCP, planar cell polarity, Pk, neuroectoderm, zebrafish, neuralation, anterior membrane, cell localization, neuroectoderm development, cell polarity, embryonic development
560	Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs. Immune response, inflammation, Th17 cells, iTregs, T cell differentiation, cytokines, immune regulation, inflammation, autoimmune, T cell subsets immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, immune regulation, T cell subsets, cytokines, immune modulation, inflammation, T cell differentiation, immune tolerance, immune signaling Immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, immune regulation, T cell differentiation, cytokines, inflammation, immunomodulation, T cell subsets, immune balance Immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, T cell differentiation, immune regulation, cytokines, immunology, inflammation, T cell subsets, immune balance immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, immune regulation, T cell differentiation, cytokines, immune balance, inflammation, regulatory T cells, Th17 cell function, immune signaling, immune homeostasis
440	Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation. Fz, PCP, planar cell polarity, Pk, notochord, zebrafish, neuralation, anterior membrane, cell polarity, morphogenesis Fz, PCP, Pk, localization, anterior membrane, notochord cells, zebrafish, neuralation, planar cell polarity, embryonic development Fz, PCP, planar cell polarity, Pk, notochord, zebrafish, neuralation, anterior membrane, cell localization, signaling pathways Fz, PCP, planar cell polarity, Pk, notochord, zebrafish, neuralation, anterior membrane, cell localization, developmental biology Fz, PCP, Pk, notochord, zebrafish, neuralation, anterior membrane, cell polarity, planar cell polarity, embryonic development
1303	Tirasemtiv has no effect on fast-twitch muscle. Tirasemtiv, effect, fast-twitch muscle, muscle response, skeletal muscle, neuromuscular, muscle fibers, clinical trials, pharmacology, muscle strength Tirasemtiv, fast-twitch muscle, drug efficacy, skeletal muscle, neuromuscular, muscle fibers, pharmacology, clinical studies, muscle response, motor neurons Tirasemtiv, fast-twitch muscle, muscle effect, neuromuscular, muscle strength, muscle fibers, pharmacology, muscle research, muscle physiology, clinical trials Tirasemtiv, effect, fast-twitch muscle, muscle response, neuromuscular, skeletal muscle, muscle fiber, pharmacology, muscle physiology, clinical studies Tirasemtiv, effect, fast-twitch muscle, muscle response, muscle fibers, skeletal muscle, neuromuscular, muscle contraction, muscle fatigue, pharmacology, muscular disorders
684	Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells. clpC, Bacillus subtilis, sporulation, efficiency, gene expression, protein degradation, cellular differentiation, bacterial sporulation, molecular biology clpC, Bacillus subtilis, sporulation, efficiency, gene deletion, protein function, cellular process, bacterial sporulation, molecular biology clpC, Bacillus subtilis, sporulation efficiency, gene deletion, protein function, bacterial sporulation, chaperone proteins, genetic mutants, cellular processes, sporulation pathway clpC, sporulation, Bacillus subtilis, efficiency, gene deletion, protein function, bacterial sporulation, cellular processes clpC, Bacillus subtilis, sporulation, efficiency, gene deletion, protein folding, stress response, cell development, sporulation pathway, genetic modification
443	GATA-3 is important for hematopoietic stem cell (HSC) function. GATA-3, hematopoietic stem cells, HSC, stem cell function, transcription factors, hematopoiesis, gene regulation, immune development, progenitor cells, cell differentiation GATA-3, hematopoietic stem cells, HSC, stem cell regulation, transcription factors, hematopoiesis, gene expression, stem cell differentiation, immune cell development, hematopoietic lineage GATA-3, hematopoietic stem cells, HSC function, transcription factors, gene regulation, hematopoiesis, stem cell biology, immune cell development, gene expression, stem cell signaling GATA-3, hematopoietic stem cells, HSC, gene regulation, transcription factors, hematopoiesis, stem cell function, immune development, progenitor cells, hematopoietic lineage GATA-3, hematopoietic stem cells, HSC, stem cell function, gene regulation, transcription factors, hematopoiesis, immune system, cell differentiation, progenitor cells
324	Deleting Raptor reduces G-CSF levels. Raptor, G-CSF, deleting, reduction, gene knockout, cytokines, immune response, granulocyte-colony stimulating factor, cellular signaling, gene expression Raptor, G-CSF, deleting, protein, gene, expression, immune response, cell signaling, cytokine, hematopoiesis Raptor, G-CSF, cytokine, gene deletion, immune response, granulocyte colony-stimulating factor, signaling pathway, inflammation, knockout, immune modulation Raptor, G-CSF, deletion, levels, reduction, gene editing, cytokines, immune response, hematopoiesis, signaling pathway, transcription factors Deleting, Raptor, reduces, G-CSF, granulocyte-colony stimulating factor, autophagy, signaling pathway, mTOR, cell proliferation, immune response
327	Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype. αvβ8, deletion, inflammatory phenotype, spontaneous, immune response, integrins, knockout, inflammation, immune regulation, cell adhesion, immune signaling αvβ8, deletion, inflammatory phenotype, spontaneous inflammation, immune response, integrin, gene knockout, inflammation, immune regulation, knockout model αvβ8, deletion, inflammatory phenotype, spontaneous, immune response, knockout, inflammation, integrins, knockout mice, immune regulation, cytokines, autoimmunity αvβ8, deletion, inflammatory phenotype, spontaneous, immune response, integrin, inflammation, knock-out, immune signaling, tissue inflammation αvβ8, deletion, inflammatory phenotype, spontaneous, immune response, tissue inflammation, integrins, immune regulation, knockout, inflammation pathway
569	In adult tissue, most T cells are memory T cells. T cells, memory T cells, adult tissue, immune response, T cell differentiation, lymphocytes, adaptive immunity, T cell subsets, immune memory, tissue-resident T cells adult tissue, T cells, memory T cells, immune system, lymphocytes, immune response, T cell memory, immunology, T cell subsets, cellular immunity T cells, memory T cells, adult tissue, T cell immunity, immune memory, T cell subsets, adaptive immunity, T lymphocytes, immune response adult tissue, T cells, memory T cells, immune system, adaptive immunity, T cell subsets, T lymphocytes, immune memory, T cell differentiation, tissue-resident T cells adult tissue, T cells, memory T cells, immune system, lymphocytes, immune response, T cell differentiation, adaptive immunity, immunology
208	CHEK2 is not associated with breast cancer. CHEK2, breast cancer, genetic association, mutation, cancer risk, gene, hereditary, genetic testing, tumor suppressor, BRCA, DNA repair, cancer susceptibility CHEK2, breast cancer, genetic mutation, cancer risk, BRCA genes, hereditary, tumor suppressor, gene association, cancer predisposition, genetic testing CHEK2, gene, mutation, breast cancer, association, genetic testing, risk factors, hereditary cancer, tumor suppressor, DNA repair CHEK2, gene, mutation, breast cancer, association, genetic risk, hereditary cancer, tumor suppressor, cancer genetics, epidemiology CHEK2, breast cancer, genetic mutation, cancer risk, genetic testing, BRCA, hereditary cancer, gene association
690	Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, 5mmol/L, metabolic abnormalities, pediatric, neurological features, skin lesions, genetic syndrome, prevalence, clinical study Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, lactate levels, pediatric, metabolic, neurological, genetic disorder, incidence, prevalence, biomarkers Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, lactate levels, pediatric, metabolic disorder, neurocutaneous syndrome, neurological symptoms, clinical study Gabonese, children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, >5mmol/L, prevalence, metabolic, neurological, clinical features, biomarkers Gabonese, children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, >5mmol/L, prevalence, metabolic markers, neurological, dermatological, epidemiology
691	Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation. Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, gene regulation, signal transduction, GEF, leukemia pathogenesis, RhoA repression, cell signaling, molecular biology Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, gene regulation, signal transduction, GTPase, cell signaling, oncogenesis, molecular pathways Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, gene regulation, signal transduction, protein interaction, cellular signaling, hematologic malignancies, Rho GTPase, molecular mechanisms Leukemia, Rho GEF, RhoA, SRC, gene regulation, signal transduction, GTPase, molecular pathways, cell signaling, hematologic malignancies Leukemia, Rho guanine nucleotide-exchange factor, RhoA, SRC activation, gene regulation, signal transduction, cell signaling, oncology, GEF, molecular pathways, hematologic malignancies
692	Leuko-increased blood increases infectious complications in red blood cell transfusion. Leukocytosis, Infection, Red blood cell transfusion, Blood components, Transfusion complications, Immune response, Inflammatory markers, Transfusion reactions, Blood safety Leukocytes, blood transfusion, infectious complications, red blood cells, leukocytosis, transfusion reactions, immune response, infection risk, transfusion safety, immune system leukocytosis, blood transfusion, infectious complications, red blood cells, immune response, transfusion reactions, leukocyte contamination, transfusion safety, infection risk, immunomodulation Leuko-increased, blood, infectious complications, red blood cell transfusion, transfusion reactions, leukocytes, immune response, transfusion medicine, infection risk, blood products leukocytosis, blood transfusion, infectious complications, red blood cells, immune response, transfusion reactions, infection risk, hematology, transfusion safety, immune suppression
1316	Transferred UCB T cells acquire a memory-like phenotype in recipients. UCB T cells, transfer, memory-like phenotype, recipients, immune response, T cell differentiation, adoptive immunotherapy, cell therapy, immune memory, hematopoietic stem cell transplant UCB, T cells, transfer, memory-like, phenotype, recipients, immune, transplantation, adoptive, immunotherapy UCB, T cells, transferred, memory-like phenotype, recipients, immune response, adoptive transfer, T cell differentiation, immunology, stem cells, immune memory UCB, T cells, transfer, memory phenotype, immunology, adoptive transfer, immune response, transplantation, cell therapy, memory T cells UCB T cells, transferred T cells, memory phenotype, immune transfer, T cell memory, hematopoietic stem cell transplantation, immune reconstitution, adoptive T cell therapy, memory-like T cells, recipient immune response
693	Leuko-reduced blood reduces infectious complications in red blood cell transfusion. Leuko-reduced blood, infectious complications, red blood cell transfusion, transfusion safety, leukoreduction, blood safety, transfusion reactions, infection risk, blood processing, immunomodulation Leuko-reduction, blood transfusion, infectious complications, red blood cells, leukoreduction, transfusion safety, infection risk, blood products, hematology, transfusion medicine Leuko-reduction, blood transfusion, infectious complications, red blood cells, infection prevention, leukoreduction, transfusion safety, immune response, blood processing, transfusion outcomes Leuko-reduction, blood transfusion, infectious complications, red blood cell, transfusion safety, leukoreduction, infection risk, blood products, transfusion medicine, hematology Leukoreduction, blood transfusion, infectious complications, red blood cell, infection risk, transfusion safety, leukocyte removal, blood safety, transfusion outcomes, immunomodulation
452	Gene expression does not vary appreciably across genetically identical cells. gene expression, genetic identity, cellular variability, gene regulation, uniformity, cell consistency, gene expression stability, genetic clones, transcriptomics, cell-to-cell variation gene expression, genetic identity, cell variability, gene regulation, cell heterogeneity, transcription levels, cellular consistency, genetic homogeneity, gene activity, cell-to-cell differences gene expression, genetic similarity, cell variability, gene regulation, cellular heterogeneity, transcription consistency, clone, molecular biology, gene regulation mechanisms, cell identity gene expression, genetic identical cells, uniform expression, cell-to-cell variability, stochastic gene expression, gene regulation, gene expression noise, cellular heterogeneity Gene expression, genetic identical cells, variability, cell-to-cell variation, uniform gene expression, cellular heterogeneity, gene regulation, transcription consistency, clones, genetic similarity
212	CR is associated with higher methylation age. CR, caloric restriction, methylation age, epigenetic clock, aging, DNA methylation, epigenetics, lifespan, biological age, aging biomarkers CR, calorie restriction, methylation age, epigenetic, aging, DNA methylation, biomarkers, longevity, aging biomarkers, epigenetics, aging research CR, caloric restriction, methylation, methylation age, epigenetics, aging, DNA methylation, lifespan, aging biomarkers, epigenetic clocks CR, caloric restriction, methylation age, DNA methylation, epigenetic aging, aging biomarkers, lifespan, epigenetics, biological age, aging research CR, caloric restriction, methylation age, epigenetic age, aging, DNA methylation, lifespan, biological aging, epigenetics, aging biomarkers
575	In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon. Saccharomyces cerevisiae, domesticated populations, chromosome aneuploidy, whole chromosome, genetic stability, yeast genetics, chromosomal abnormalities, genome variation, yeast domestication, aneuploidy frequency Saccharomyces cerevisiae, domesticated populations, chromosome aneuploidy, whole chromosome, genetic variation, yeast genetics, chromosomal abnormalities, genome stability, domestication effects, aneuploidy frequency Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, uncommon, yeast genetics, chromosomal abnormalities, genome stability, domestication effects, microbial genetics, chromosome duplication Saccharomyces cerevisiae, domestication, chromosome aneuploidy, whole chromosome, genetic variation, yeast genetics, structural chromosomal abnormalities, genome stability, industrial strains, genomic instability Saccharomyces cerevisiae, domesticated populations, chromosome aneuploidy, whole chromosome, genetic variation, yeast genetics, aneuploidy prevalence, chromosome instability, genomic stability, evolutionary adaptation
213	CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. CRP, predictive value, postoperative mortality, coronary artery bypass graft, CABG, inflammation markers, surgical outcomes, cardiovascular surgery, prognostic indicators, biomarkers, perioperative risk CRP, predictive, postoperative mortality, coronary artery bypass graft, CABG, inflammation markers, surgical outcomes, prognostic indicators, cardiovascular surgery, biomarker accuracy CRP, predictive value, postoperative mortality, coronary artery bypass graft, CABG, inflammation biomarkers, surgical outcomes, prognostic indicators, cardiovascular surgery, inflammatory response CRP, predictive value, postoperative mortality, coronary artery bypass graft, CABG, inflammation markers, prognosis, surgery outcomes, cardiovascular surgery, biomarker, risk assessment CRP, predictive value, postoperative mortality, coronary artery bypass graft, CABG, inflammation markers, prognostic indicators, cardiovascular surgery, risk assessment, surgery outcomes
577	In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers. mice, P. chabaudi, parasites, proliferation, early infection, inoculation, low doses, high doses, parasite growth, infection dynamics, dose-dependent, parasitemia P. chabaudi, mice, parasite proliferation, early infection, inoculation dose, parasitemia, infection dynamics, parasitic load, host response, infection timing mice, P. chabaudi, parasites, proliferation, infection, inoculation, parasite load, early infection, parasite growth, infection dose, immune response mice, P. chabaudi, parasites, proliferation, early infection, inoculation dose, low inoculum, high inoculum, parasite growth, infection dynamics mice, P. chabaudi, parasites, proliferation, infection, inoculation, dose-dependent, parasitemia, early infection, parasitic growth
578	In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis. mouse models, CSF1R, MOZ-TIF2, leukemia, leukemogenesis, gene mutation, hematological malignancies, fusion proteins, oncogenesis, disease mechanism mouse models, CSF1R, MOZ-TIF2, leukemogenesis, gene loss, leukemia development, chromatin modifiers, transcription factors, oncogenesis, hematopoiesis mouse models, CSF1R, MOZ-TIF2, leukemia, leukemogenesis, hematologic malignancies, gene loss, fusion proteins, oncogenesis, molecular pathways mouse models, CSF1R, MOZ-TIF2, leukemia, leukemogenesis, gene loss, hematopoiesis, cancer pathways, oncogenes, tumor suppressors mouse models, CSF1R, MOZ-TIF2, leukemia, leukemogenesis, gene loss, hematopoiesis, tumorigenesis, molecular pathways, hematological malignancies
216	CX3CR1 on the Th2 cells impairs T cell survival CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, T cell function, cell signaling, immune regulation, cytokines, immunology CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, immune regulation, T cell impairment, Th2 differentiation, cell survival signaling, immune modulation CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, T cell function, immune impairment, cell survival, immunology, cytokines CX3CR1, Th2 cells, T cell survival, immune response, receptor expression, T cell function, chemokine receptors, immunology, cell signaling, inflammation CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptors, cell signaling, T cell function, immune suppression, cytokine profile, cell adhesion, chemokine signaling, immune regulation
217	CX3CR1 on the Th2 cells promotes T cell survival CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, T cell differentiation, cell signaling, cytokines, immune regulation, receptor expression CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, T cell function, cell signaling, immune regulation, cytokines, T cell proliferation CX3CR1, Th2 cells, T cell survival, immune signaling, chemokine receptor, T cell differentiation, immune response, cell migration, cytokine signaling, immunology CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, cytokines, T cell differentiation, cell signaling, immune regulation, receptor expression CX3CR1, Th2 cells, T cell survival, immune response, chemokine receptor, T cell differentiation, cell signaling, immune cell migration, cytokines, T cell phenotype
338	Dexamethasone decreases risk of postoperative bleeding. Dexamethasone, postoperative bleeding, bleeding risk, corticosteroids, surgical outcomes, anti-inflammatory, bleeding prevention, perioperative care, surgery, postoperative complications Dexamethasone, postoperative bleeding, risk reduction, corticosteroids, surgery, bleeding prevention, anti-inflammatory, postoperative complications, surgical outcomes Dexamethasone, postoperative bleeding, risk reduction, corticosteroids, surgery, bleeding prevention, inflammation, anti-inflammatory, surgical complications, bleeding control Dexamethasone, postoperative bleeding, risk reduction, corticosteroids, surgical complications, inflammation, bleeding prevention, anti-inflammatory, perioperative management, surgical outcomes Dexamethasone, postoperative bleeding, bleeding risk, corticosteroids, anti-inflammatory, surgery, bleeding complications, postoperative, surgical outcomes, corticosteroid effects
218	CX3CR1 on the Th2 cells promotes airway inflammation. CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, inflammation, respiratory, allergy, immune cells, cytokines CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, allergic airway disease, T cell signaling, inflammation mechanisms, respiratory immunity, immune cell recruitment CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, inflammation, respiratory, allergy, immune signaling, T cells CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, allergic asthma, inflammation pathway, immune cell trafficking, cytokines, respiratory inflammation CX3CR1, Th2 cells, airway inflammation, chemokine receptor, immune response, inflammation, respiratory, immune cells, cytokines, chemokines, allergic inflammation, airway disease
219	CX3CR1 on the Th2 cells suppresses airway inflammation. CX3CR1, Th2 cells, airway inflammation, immune response, cellular signaling, inflammation suppression, immunology, respiratory immunity, cytokines, chemokine receptors CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, inflammation suppression, respiratory immunology, immune regulation, T cell function, airway disease CX3CR1, Th2 cells, airway inflammation, immune response, cytokines, immune regulation, inflammation suppression, respiratory immunity CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, allergic asthma, cytokines, inflammation suppression, immune regulation, respiratory immunity CX3CR1, Th2 cells, airway inflammation, immune response, chemokine receptor, inflammation suppression, respiratory health, immune regulation, airway disease, immune cell signaling
1319	Transplanted human glial cells can differentiate within the host animal. transplantation, human glial cells, differentiation, host animal, neural cells, stem cells, neurobiology, brain, glial cell development, cell integration transplanted, human, glial cells, differentiation, host animal, neurobiology, neural transplantation, glial cell development, neural integration, cell therapy transplanted, human, glial cells, differentiation, host, animal, neurobiology, neuroscience, cell therapy, cellular integration transplantation, human glial cells, differentiation, host animal, neurobiology, neurogenesis, cellular integration, glial cell transplant, neural stem cells, brain regeneration transplanted, human, glial cells, differentiation, host animal, neurobiology, neural stem cells, glial cell types, in vivo, transplantation, neural regeneration
100	All hematopoietic stem cells segregate their chromosomes randomly. hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, mitosis, chromosome distribution, cell division, genetic variability, asymmetric division, stem cell biology hematopoietic stem cells, chromosomes, segregation, genetic variation, cell division, meiosis, mitosis, genetic inheritance, chromosome distribution, stem cell biology hematopoietic stem cells, chromosome segregation, random segregation, stem cell biology, chromosomal behavior, cell division, hematopoiesis, genetic inheritance, mitosis, cellular genetics hematopoietic stem cells, chromosome segregation, random segregation, stem cell biology, genetic inheritance, cell division, chromosomal behavior, hematopoiesis, stem cell research, cell cycle hematopoietic stem cells, chromosomes, segregation, randomness, mitosis, cell division, genetic variation, stem cell biology, chromosomal inheritance, cell cycle
1204	The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells. H3K4me3, H3K79me2, chromatin modifications, hair follicle stem cells, quiescence, epigenetics, stem cell niche, gene regulation, histone marks, cell cycle, differentiation H3K4me3, H3K79me2, chromatin modifications, hair follicle stem cells, quiescence, epigenetics, stem cell regulation, histone marks, transcription regulation, cellular quiescence H3K4me3, H3K79me2, chromatin modifications, hair follicle stem cells, quiescent cells, epigenetics, stem cell niche, gene regulation, histone marks, cell cycle, tissue renewal H3K4me3, H3K79me2, chromatin modifications, hair follicle stem cells, quiescent cells, epigenetics, gene regulation, stem cell biology, histone marks, chromatin state H3K4me3, H3K79me2, chromatin modifications, hair follicle stem cells, quiescence, epigenetics, stem cell regulation, gene expression, chromatin state, tissue stem cells
343	Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. diabetic patients, acute coronary syndrome, bleeding risk, short-term risk, long-term risk, cardiovascular events, hematologic complications, thrombosis, glycemic control, cardiovascular disease, hemorrhagic events diabetic patients, acute coronary syndrome, ACS, bleeding risk, short-term, long-term, cardiovascular events, diabetes, coronary, hemorrhage, risk assessment, prognosis diabetic patients, acute coronary syndrome, ACS, bleeding risk, short-term, long-term, cardiovascular complications, diabetes mellitus, bleeding events, risk factors diabetic patients, acute coronary syndrome, ACS, bleeding risk, short-term, long-term, cardiovascular events, diabetes, thrombosis, hemorrhage, risk factors, prognosis, cardiovascular complications diabetic patients, acute coronary syndrome, ACS, bleeding risk, short-term risk, long-term risk, hemorrhage, cardiovascular complications, diabetes mellitus, thrombotic events, anticoagulation, antiplatelet therapy, risk factors, prognosis
1202	The center of the granuloma in an immune cell induces a pro-inflammatory immune response. granuloma, immune cell, center, pro-inflammatory, immune response, inflammation, macrophage, cytokines, immune system, infectious disease granuloma, immune cell, center, pro-inflammatory, immune response, inflammation, cytokines, macrophages, immune system, pathology granuloma, immune cell, center, pro-inflammatory, immune response, inflammation, cytokines, macrophages, immune system, immune activation granuloma, immune cell, center, pro-inflammatory, immune response, inflammation, immune system, cellular activity, immune microenvironment granuloma, immune cell, center, inflammation, immune response, cytokines, macrophages, pro-inflammatory, immune activation, granulomatous inflammation
587	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers. transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, stem cells, neural progenitors, fluorescence imaging, gene expression, cellular biology transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation, colocalization, fluorescent markers, neuronal stem cells, pluripotency, gene expression, cell cycle transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, gene expression, stem cells, neural progenitors, fluorescence microscopy, cell markers transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation markers, colocalization, stem cells, neural progenitors, fluorescence microscopy, gene expression, cell cycle transgenic mice, green fluorescent protein, Sox2 promoter, cell proliferation, colocalization, gene expression, stem cells, neurogenesis, fluorescence microscopy, GFP, promoter activity
1200	The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1. ML-SA1, binding orientation, hTRPML1, hTRPML2, activator, ligand binding, structural differences, receptor conformation, channel modulation, TRPML channels ML-SA1, binding orientation, hTRPML2, hTRPML1, activator, receptor binding, ligand orientation, TRPML channels, structural differences, molecule interaction, binding sites ML-SA1, hTRPML2, hTRPML1, binding orientation, activator, ligand binding, protein-ligand interaction, structural differences, channel activation, molecular docking, cryo-EM, conformational change ML-SA1, hTRPML1, hTRPML2, binding orientation, activator, receptor binding, structural differences, ligand binding, TRPML channels, protein interaction, molecular docking, conformational change, channel activation ML-SA1, hTRPML1, hTRPML2, binding orientation, activator, ion channel, ligand binding, structural differences, molecular docking, protein-ligand interaction
589	In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events. ADHD medications, cardiovascular risk, young adults, middle-aged adults, remote use, current use, serious cardiovascular events, medication safety, stimulant medications, non-stimulant medications, epidemiology, health outcomes, medical research ADHD medications, young adults, middle-aged adults, cardiovascular risk, serious cardiovascular events, current use, remote use, medication safety, adult ADHD, cardiovascular health, medication effects ADHD medications, young adults, middle-aged adults, current use, remote use, cardiovascular risk, serious cardiovascular events, medication safety, mental health, pharmacology, adult health ADHD medications, young adults, middle-aged adults, current use, remote use, cardiovascular events, risk, safety, adults, medication effects, long-term use, serious events ADHD, medication, young adults, middle-aged adults, current use, remote use, cardiovascular risk, serious events, safety, side effects, adults, neuropsychiatric, treatment effects, health outcomes
1320	Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons. transplanted cells, human glial progenitors, neural network, host animals, neuronal integration, neural connectivity, gliogenesis, neuroglia, cell transplantation, neurobiology, neural development transplanted, human, glial progenitor cells, neural network, host animals, neurons, incapable, integration, neurogenesis, glia, neural connectivity, transplantation, cell differentiation, neural modeling transplanted cells, human glial progenitors, neural network, host animals, neuronal integration, cell transplantation, neuroregeneration, glial cells, neural connectivity, neurobiology transplanted, human, glial progenitor cells, neural network, host animals, neurons, incapability, cell transplantation, neural integration, glial cells, neuroregeneration, neural connectivity transplantation, human glial progenitor cells, neural network, host animals, neuroglia, neural integration, cell differentiation, brain repair, neural connectivity, cell transplantation, neuroglial interaction
903	PD-1 triggering on monocytes reduces IL-10 production by monocytes. PD-1, monocytes, IL-10, immune regulation, checkpoint blockade, cytokine production, immune suppression, immune response, monocyte activation, immune signaling PD-1, monocytes, IL-10, immune regulation, immune checkpoint, cytokine production, immune suppression, monocyte signaling, PD-1 pathway, immunomodulation PD-1, monocytes, IL-10, cytokine, immune regulation, immune checkpoint, immune response, monocyte activation, immune suppression, signaling pathway, immune modulation, PD-1 ligation PD-1, monocytes, IL-10, immune regulation, immune checkpoint, cytokine production, immune suppression, monocyte activation, PD-1 signaling, immune response, inflammation, immune modulation, innate immunity PD-1, monocytes, IL-10, immune regulation, immune checkpoint, cytokine production, monocyte activation, immune suppression, immune response, immunomodulation
904	PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells. PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, cytoskeletal rearrangement, immune cell signaling, stromal interactions PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, cytoskeletal rearrangement, immune cells, cell movement PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, immune response, cell polarization, cytoskeletal dynamics PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, cellular activation, immune response, cytoskeletal rearrangement PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, immune response, cytoskeletal rearrangement, cell activation
1207	The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation. myosin-II, isoform, B isoform, A isoform, switch, hematopoietic differentiation, composition, polarization, homogeneity, cytoskeleton, muscle proteins, cell differentiation myosin-II, isoform switching, B isoform, A isoform, hematopoietic differentiation, protein composition, cytoskeleton, cellular differentiation, filament assembly, isoform regulation myosin-II, isoform, B isoform, A isoform, polarization, homogeneity, hematopoietic differentiation, protein switching, molecular subtypes, cell differentiation myosin-II, isoform, B isoform, A isoform, polarization, homogeneity, hematopoietic differentiation, protein switch, isoform transition, molecular dynamics myosin-II, isoform switch, B isoform, A isoform, polarization, homogenization, hematopoietic differentiation, cytoskeleton, contractility, cell differentiation, molecular dynamics