907	PGE 2 promotes intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes. PGE2, intestinal tumor growth, tumor suppressor genes, DNA repair genes, gene expression, prostaglandin E2, colorectal cancer, carcinogenesis, gene regulation, tumor promotion, cancer biology, molecular pathways, gene alteration, oncogenesis, gastrointestinal tumors PGE2, intestinal tumor growth, gene expression, tumor suppressor genes, DNA repair genes, prostaglandin E2, colorectal cancer, carcinogenesis, gene regulation, tumor microenvironment PGE2, intestinal tumor growth, tumor suppressor genes, DNA repair genes, gene expression, prostaglandin E2, colorectal cancer, tumor promotion, oncogenesis, molecular mechanisms, gene regulation, cancer progression, inflammation, signaling pathways PGE2, intestinal tumor growth, tumor suppressor genes, DNA repair genes, gene expression, prostaglandin E2, colorectal cancer, carcinogenesis, molecular mechanisms, tumorigenesis, gene regulation, signaling pathways PGE2, intestinal tumor growth, prostaglandin E2, gene expression, tumor suppressor genes, DNA repair genes, colorectal cancer, carcinogenesis, molecular pathways, cancer progression, inflammation, COX-2, epithelial cells, oncogenesis, signal transduction
350	Discrimination between the initiator and elongation tRNAs depends on the translation initiation factor IF3. initiator tRNA, elongator tRNA, IF3, translation initiation factor, tRNA discrimination, translation initiation, protein synthesis, bacterial translation, ribosome, tRNA selection, initiation complex, molecular recognition, prokaryotic translation initiator tRNA, elongation tRNA, translation initiation, IF3, initiation factor 3, tRNA discrimination, bacterial translation, protein synthesis, ribosome binding, start codon recognition, tRNA selection, translation fidelity initiator tRNA, elongation tRNA, discrimination, translation initiation, IF3, initiation factor 3, tRNA selection, protein synthesis, ribosome, bacterial translation, tRNA binding, translation regulation, initiation complex, tRNA specificity initiator tRNA, elongation tRNA, translation initiation, IF3, discrimination, translation initiation factor, tRNA selection, protein synthesis, ribosome, bacterial translation tRNA discrimination, initiator tRNA, elongation tRNA, translation initiation, IF3, initiation factor IF3, ribosome, protein synthesis, translation regulation, bacterial translation, tRNA selection, molecular recognition, translation machinery, initiation complex, mRNA translation
230	Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less that non-carries. alcohol metabolism, aldehyde dehydrogenase deficiency, genetic mutation, drinking behavior, alcohol consumption, alcohol intolerance, ADH deficiency, ALDH2 gene, mutation carriers, non-carriers, alcohol use genetics, alcohol sensitivity, alcohol aversion, reduced drinking, genetic influence on drinking alcohol, aldehyde dehydrogenase, deficiency, mutation, carriers, non-carriers, drink less, alcohol consumption, genetic mutation, alcohol metabolism, enzyme deficiency, drinking behavior, genetics, alcohol intolerance alcohol dehydrogenase deficiency, aldehyde dehydrogenase deficiency, mutation, carriers, alcohol consumption, drinking behavior, genetic mutation, non-carriers, alcohol metabolism, ALDH2 deficiency, alcohol intolerance, genetic predisposition, reduced alcohol intake, alcohol sensitivity alcohol, aldehyde dehydrogenase, deficiency, mutation, carriers, non-carriers, drinking behavior, alcohol metabolism, ADH, ALDH, alcohol consumption, genetic variation alcohol aldehyde dehydrogenase, deficiency mutation, ADH deficiency, alcohol consumption, genetic carriers, drinking behavior, enzyme deficiency, non-carriers, genetics of drinking, alcohol metabolism, gene mutation, alcohol tolerance, ALDH2 mutation, alcohol sensitivity, alcohol use genetics
593	Incidence of heart failure decreased by 10% in women since 1979. heart failure, incidence, decrease, 10%, women, 1979, epidemiology, trends, cardiovascular disease, gender differences, temporal analysis, population study heart failure, incidence, decrease, women, 10 percent, trend, 1979, epidemiology, temporal change, gender differences, cardiovascular disease, prevalence, reduction, historical data, female, time period heart failure, incidence, women, decrease, 10%, trend, 1979, epidemiology, gender differences, temporal change, cardiovascular disease, prevalence, female, historical data heart failure, incidence, decrease, women, 10 percent, since 1979, trends, epidemiology, gender differences, temporal analysis, cardiovascular disease, female, prevalence, reduction heart failure, incidence, decrease, 10 percent, women, female, trend, 1979, epidemiology, cardiovascular disease, prevalence, time period, gender differences, reduction
1216	The extracellular domain of TMEM27 is cleaved in human beta cells. TMEM27, extracellular domain, cleavage, human beta cells, proteolysis, protein processing, islet cells, membrane protein, beta cell-specific, pancreatic islets TMEM27, extracellular domain, cleavage, human beta cells, proteolysis, islet cells, pancreatic beta cells, membrane protein, shedding, beta-cell surface, TMEM27 processing TMEM27, extracellular domain, cleavage, human beta cells, protein processing, membrane protein, islet cells, proteolytic cleavage, pancreatic beta cells, cell surface proteins TMEM27, extracellular domain, cleavage, human beta cells, proteolysis, cell surface protein, pancreatic islets, insulin secretion, membrane protein, β-cells, protein shedding, endocrine pancreas TMEM27, extracellular domain, cleavage, human beta cells, proteolysis, islets, cell surface protein, membrane protein, beta cell function, peptide cleavage, pancreatic islets, insulin secretion
1337	Ubiquitin ligase UBC13 generates a K63-linked polyubiquitin moiety at PCNA K164. UBC13, ubiquitin ligase, K63-linked polyubiquitin, PCNA, K164, DNA damage, ubiquitination, E2 enzyme, post-translational modification, DNA repair, ubiquitin chain, protein modification UBC13, ubiquitin ligase, K63-linked polyubiquitin, PCNA, K164, ubiquitination, DNA repair, post-translational modification, enzyme specificity, ubiquitin chain, protein modification Ubiquitin ligase, UBC13, K63-linked polyubiquitin, polyubiquitin chain, PCNA, K164, ubiquitination, DNA damage response, post-translational modification, protein regulation, E2 enzyme, ubiquitin conjugation Ubiquitin ligase, UBC13, K63-linked polyubiquitin, PCNA, K164, ubiquitination, DNA repair, post-translational modification, E2 enzyme, RAD6 pathway UBC13, ubiquitin ligase, K63-linked polyubiquitin, polyubiquitin chain, PCNA, K164, ubiquitination, post-translational modification, DNA repair, protein modification, lysine 164, ubiquitin conjugation
232	Cataract and trachoma are the primary cause of blindness in Southern Sudan. cataract, trachoma, blindness, causes, Southern Sudan, eye diseases, vision loss, epidemiology, sub-Saharan Africa, public health cataract, trachoma, primary cause, blindness, Southern Sudan, eye diseases, vision loss, epidemiology, sub-Saharan Africa, ocular health cataract, trachoma, blindness, primary cause, Southern Sudan, eye diseases, vision loss, prevalence, epidemiology, risk factors, Sub-Saharan Africa, public health, ocular health, Sudan blindness statistics cataract, trachoma, blindness, primary causes, Southern Sudan, eye diseases, vision loss, sub-Saharan Africa, ocular health, preventable blindness cataract, trachoma, blindness, primary cause, Southern Sudan, ocular diseases, vision impairment, eye health, Sudan, preventable blindness, epidemiology, public health, African blindness, causes of blindness
1336	UCB T cells reduce TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, allogeneic transplant, T cell receptor, immune reconstitution, lymphocyte diversity, post-transplant, hematopoietic stem cell transplant, immune recovery UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, graft, immunology, allogeneic transplant, receptor diversity, lymphocyte, immune response UCB, T cells, TCR diversity, transplantation, immune repertoire, umbilical cord blood, T cell receptor, diversity reduction, graft, immune reconstitution UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, allogeneic transplant, T cell receptor, immune recovery, lymphocyte diversity, post-transplant UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, allogeneic transplant, T cell receptor, diversity loss, immune reconstitution, graft, lymphocyte, post-transplant, immune recovery
233	Cell autonomous sex determination in somatic cells does not occur in Galliformes. cell-autonomous sex determination, somatic cells, Galliformes, avian sex determination, non-cell-autonomous, bird genetics, sexual differentiation, sex chromosomes, poultry biology, molecular mechanisms cell autonomous, sex determination, somatic cells, Galliformes, avian sex determination, cell-autonomous mechanism, sex differentiation, birds, non-occurrence, sexual development, gonadal sex, vertebrates cell autonomous, sex determination, somatic cells, Galliformes, non-occurrence, avian sex determination, bird development, cellular autonomy, sexual differentiation, galliform birds cell autonomous, sex determination, somatic cells, Galliformes, avian sex determination, non-cell-autonomous, chicken, quail, gonadal development, avian somatic cells, sexual differentiation, bird sex chromosomes, ZW system, galliform birds, embryonic development cell autonomous, sex determination, somatic cells, Galliformes, avian sex determination, chicken sex determination, bird sexual differentiation, non-cell-autonomous, gonadal development, bird genetics, Galliformes reproduction, sexual dimorphism, gene expression, vertebrate sex determination, ZW system
354	Downregulation and mislocalization of Scribble prevents cell transformation and mammary tumorigenesis. Scribble, downregulation, mislocalization, cell transformation, mammary tumorigenesis, breast cancer, tumor suppression, cell polarity, oncogenesis, epithelial cells Scribble, downregulation, mislocalization, cell transformation, mammary tumorigenesis, breast cancer, tumor suppression, cell polarity, epithelial cells, oncogenesis, Scribble complex, cancer progression Scribble, downregulation, mislocalization, cell transformation, mammary tumorigenesis, breast cancer, tumor suppressor, cell polarity, epithelial cells, cancer prevention Scribble, downregulation, mislocalization, cell transformation, mammary tumorigenesis, tumor suppressor, breast cancer, cell polarity, cancer progression, epithelial cells Downregulation, mislocalization, Scribble, cell transformation, mammary tumorigenesis, breast cancer, tumor suppressor, epithelial polarity, cancer progression, cell polarity, oncogenesis, protein localization, mammary gland, signaling pathways
475	Glycolysis is one of the primary glycometabolic pathways in cells. glycolysis, glycometabolism, metabolic pathways, primary pathways, cellular metabolism, glucose metabolism, energy production, biochemical pathways, carbohydrate metabolism, cytoplasm, ATP production, glycolytic pathway glycolysis, glycometabolic pathways, cellular metabolism, glucose catabolism, energy production, metabolic pathways, cytoplasm, ATP generation, glucose breakdown, biochemistry, cellular respiration glycolysis, glycometabolic pathways, cellular metabolism, glucose metabolism, energy production, primary pathway, metabolic pathways, biochemistry, cell metabolism, glycolytic pathway glycolysis, glycometabolic pathways, cellular metabolism, glucose metabolism, energy production, metabolic pathways, catabolism, cytoplasm, ATP production, glucose breakdown, biochemistry, cell metabolism, carbohydrate metabolism, metabolic regulation glycolysis, glycometabolic pathways, cellular metabolism, glucose metabolism, energy production, metabolic pathway, carbohydrate metabolism, cell metabolism, glycolytic pathway, bioenergetics
113	Angiotensin converting enzyme inhibitors are associated with increased risk for functional renal insufficiency. Angiotensin converting enzyme inhibitors, ACE inhibitors, increased risk, functional renal insufficiency, renal dysfunction, nephrotoxicity, kidney function, adverse effects, risk factors, antihypertensive drugs, renal impairment, drug-induced nephropathy angiotensin converting enzyme inhibitors, ACE inhibitors, functional renal insufficiency, kidney function, risk factors, renal impairment, nephrotoxicity, adverse effects, drug-induced renal dysfunction, hypertension medications, chronic kidney disease, ACEi and renal risk, renal side effects, pharmacovigilance, renal insufficiency mechanisms angiotensin converting enzyme inhibitors, ACE inhibitors, increased risk, functional renal insufficiency, renal function, kidney insufficiency, adverse effects, nephrotoxicity, drug-induced renal dysfunction, renal risk factors angiotensin converting enzyme inhibitors, ACE inhibitors, functional renal insufficiency, renal dysfunction, kidney insufficiency, risk factors, drug-induced nephropathy, adverse effects, renal risk, nephrotoxicity angiotensin converting enzyme inhibitors, ACE inhibitors, functional renal insufficiency, renal dysfunction, kidney function, risk factors, nephrotoxicity, drug-induced renal failure, hypertension treatment, adverse effects, renal impairment, kidney injury
1335	UCB T cells maintain high TCR diversity after transplantation. UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune reconstitution, allogeneic transplant, T cell repertoire, T cell recovery, adaptive immunity, hematopoietic stem cell transplant, post-transplant immunology UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, allogeneic transplant, immune reconstitution, lymphocyte diversity, adaptive immunity UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, adaptive immunity, graft, lymphocytes, T cell receptors, post-transplant, hematopoietic stem cell, immune recovery, clonality, diversity maintenance UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, lymphocyte diversity, post-transplant, immune reconstitution, T-cell receptor, allogeneic transplant, hematopoietic stem cell transplantation, immune recovery UCB, T cells, TCR diversity, transplantation, umbilical cord blood, immune repertoire, post-transplant, immune reconstitution, adoptive immunity, T cell receptor, hematopoietic stem cell transplantation
597	Incidence rates of cervical cancer have decreased. cervical cancer, incidence rates, trends, decrease, epidemiology, statistics, prevalence, reduction, time period, temporal analysis cervical cancer, incidence rates, trends, decrease, epidemiology, cancer statistics, prevalence, temporal changes, reduction, population studies cervical cancer, incidence rates, cancer trends, cervical cancer statistics, cervical cancer decline, epidemiology, cancer incidence, temporal trends, cancer prevention, cervical cancer reduction cervical cancer, incidence rates, trend, decline, epidemiology, reduction, cancer statistics, temporal analysis, cancer prevalence, public health, disease burden, cancer registries, time trends, reporting rates, population-based studies cervical cancer, incidence rates, decreasing trends, epidemiology, cancer statistics, decline, time trends, public health, cancer prevention, cancer incidence
1213	The deregulated and prolonged activation of monocytes has deleterious effects in inflammatory diseases. deregulated monocyte activation, prolonged monocyte activation, monocytes, inflammatory diseases, immune dysregulation, chronic inflammation, monocyte-mediated pathology, inflammation, immune response, pathogenic monocytes, monocyte dysfunction, deleterious effects deregulated monocyte activation, prolonged monocyte activation, monocytes, deleterious effects, inflammatory diseases, chronic inflammation, immune dysregulation, monocyte-driven pathology, innate immunity, inflammation pathogenesis deregulated monocyte activation, prolonged monocyte activation, inflammatory diseases, monocyte dysfunction, immune response, chronic inflammation, monocyte-mediated pathology, immunopathology, inflammation, pathogenic monocytes, deleterious immune effects deregulated monocyte activation, prolonged monocyte activation, inflammatory diseases, monocytes, immune response, inflammation, deleterious effects, monocyte-mediated pathology, chronic inflammation, immune dysregulation, innate immunity, pathogenic monocytes deregulated monocyte activation, prolonged monocyte activation, deleterious effects, inflammatory diseases, monocyte dysregulation, chronic inflammation, immune response, monocyte-mediated pathology, inflammation pathogenesis, immune cell activation
598	Incidence rates of cervical cancer have increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer. cervical cancer, incidence rates, nationwide screening programs, cytology, uterine cervical cancer, cancer detection, screening impact, population screening, epidemiology, Pap smear, cancer trends, cervical neoplasia cervical cancer, incidence rates, nationwide screening programs, cytology, uterine cervical cancer, cancer detection, screening impact, cancer trends, pap smear, cervical cytology, cancer epidemiology cervical cancer, incidence rates, nationwide screening, cytology, uterine cervical cancer, cancer detection, screening programs, epidemiology, cancer trends, cancer prevention, population-based screening, cytology-based screening cervical cancer, incidence rates, screening programs, cytology, uterine cervical cancer, nationwide screening, cancer detection, cancer epidemiology, population screening, Pap smear, cancer trends, gynecologic oncology cervical cancer, incidence rates, nationwide screening programs, cytology, uterine cervical cancer, cancer detection, cancer screening, epidemiology, population-based screening, screening effectiveness, cytologic screening, detection rate, public health, women's health, cancer trends, gynecologic oncology
115	Anthrax spores can be disposed of easily after they are dispersed. anthrax, spores, disposal, decontamination, destruction, bioterrorism, biodefense, anthrax spore survival, inactivation, cleanup, hazardous materials, spore removal, biological agents, contamination, disinfection anthrax, anthrax spores, spore disposal, spore decontamination, anthrax deactivation, biological agent disposal, spore destruction, anthrax cleanup, bioterrorism response, hazardous material disposal, Bacillus anthracis, biohazard waste, decontamination methods, germicidal techniques, biological contamination control Anthrax, spores, disposal, decontamination, biodefense, hazardous materials, spore persistence, spore resistance, bioterrorism, disinfection methods, environmental cleanup, pathogen eradication, spore inactivation, contamination control, public health, infectious agents anthrax, spores, disposal, decontamination, destruction, sterilization, biodefense, hazardous materials, biological agents, spore inactivation, disinfection, biosafety, containment, cleanup, bioterrorism, remediation anthrax, spores, disposal, decontamination, destruction, biodefense, bioterrorism, deactivation, sterilization, environmental cleanup, containment, spore inactivation, hazardous waste, pathogen control
236	Cell autonomous sex determination in somatic cells occurs in Passeriformes. cell autonomous, sex determination, somatic cells, Passeriformes, avian sex determination, bird sex chromosomes, cell autonomy, gonadal differentiation, bird development, sexual differentiation, passerine birds, cell-intrinsic sex determination, embryonic development, sexual dimorphism, ZW system cell autonomous, sex determination, somatic cells, Passeriformes, avian sex determination, bird somatic cells, intrinsic sex determination, bird genetics, cell-intrinsic mechanisms, passerine birds, sexual differentiation, birds, somatic sex determination, avian biology cell autonomous, sex determination, somatic cells, Passeriformes, avian sex differentiation, bird cell fate, intrinsic sex determination, passerine birds, cell-autonomous mechanisms, gonadal development, embryonic development, sexual dimorphism, molecular pathways, avian genetics cell autonomous, sex determination, somatic cells, Passeriformes, birds, avian, sexual differentiation, cell-intrinsic, gonadal development, zebra finch, sexual identity, genetic sex, germ cells, avian development, autonomous sex determination cell autonomous, sex determination, somatic cells, Passeriformes, songbirds, avian sex determination, cellular sex identity, intrinsic sex determination, bird somatic cells, gonadal differentiation, cell-autonomous mechanisms, avian biology
478	Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol. Golli-deficient, T-cells, anergic phenotype, adaptive immune response, Ca2+, calcium, cytosol, differentiation, immune tolerance, T lymphocytes, Golli, anergy, intracellular calcium, immune regulation, T cell signaling Golli-deficient, T-cells, anergic phenotype, adaptive immune response, cytosolic Ca2+, calcium signaling, T-cell differentiation, immune tolerance, Golli proteins, T-cell anergy, calcium-mediated signaling, immune regulation Golli-deficient, T-cells, anergic phenotype, adaptive immune response, increased Ca2+, cytosolic calcium, T-cell differentiation, immune tolerance, calcium signaling, Golli protein, T-cell anergy, immunology Golli-deficient, T-cells, differentiate, anergic phenotype, adaptive immune response, increased Ca2+, cytosol, calcium signaling, T-cell anergy, immunology, T-cell differentiation, Golli protein, calcium homeostasis, immune regulation, lymphocytes Golli-deficient, T-cells, T lymphocytes, anergic phenotype, anergy, adaptive immune response, Ca2+, calcium, cytosol, differentiation, immune regulation, immunology, Golli proteins, T-cell activation, T-cell tolerance, calcium signaling, immune cell signaling, T-cell exhaustion, Golli knockout, calcium influx
1332	Tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) are pro-inflammatory cytokines that inhibit IL-6 and IL-10. tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, cytokine inhibition, IL-6, IL-10, cytokine interaction, inflammatory response, immune regulation, cytokine signaling, immune modulation, cytokine cross-talk TNF-α, tumor necrosis factor alpha, IL-1, interleukin-1, pro-inflammatory cytokines, cytokine inhibition, IL-6, interleukin-6, IL-10, interleukin-10, inflammatory response, immune regulation, cytokine signaling, cytokine interaction, inflammation mediators TNF-α, tumor necrosis factor alpha, IL-1, interleukin-1, pro-inflammatory cytokines, cytokine inhibition, IL-6, interleukin-6, IL-10, interleukin-10, cytokine regulation, inflammation, immune response, anti-inflammatory cytokines, cytokine interaction TNF-α, tumor necrosis factor alpha, IL-1, interleukin-1, pro-inflammatory cytokines, IL-6 inhibition, IL-10 inhibition, cytokine regulation, inflammation, cytokine interaction, immune response, cytokine crosstalk, inflammatory pathways Tumor necrosis factor alpha, TNF-α, interleukin-1, IL-1, pro-inflammatory cytokines, cytokine inhibition, IL-6, interleukin-6, IL-10, interleukin-10, cytokine regulation, immune response, inflammation mediators, cytokine interaction, immune modulation
237	Cells lacking clpC have a defect in sporulation efficiency in Bacillus subtilis. clpC, sporulation efficiency, Bacillus subtilis, clpC knockout, sporulation defect, clpC mutant, sporulation phenotype, clpC deletion, Bacillus subtilis sporulation, clpC deficiency clpC knockout, sporulation defect, Bacillus subtilis, clpC deletion, sporulation efficiency, clpC mutant, sporulation phenotype, clpC gene, spore formation, Bacillus subtilis mutants, clpC disruption, sporulation process clpC, Bacillus subtilis, sporulation efficiency, clpC knockout, cell sporulation defect, clpC mutant, sporulation, bacteria, clpC deletion, Bacillus sporulation, sporulation phenotype, clpC disruption clpC knockout, sporulation defect, Bacillus subtilis, sporulation efficiency, clpC mutant, bacterial sporulation, gene deletion, clpC function, sporulation mechanism, sporulation phenotype clpC deletion, sporulation defect, Bacillus subtilis, clpC knockout, sporulation efficiency, cell differentiation, sporulation mutants, clpC mutants, sporulation genes, Bacillus subtilis genetics, clpC function, bacterial sporulation
238	Cells undergoing methionine restriction may activate miRNAs. methionine restriction, cells, miRNA activation, microRNA, gene expression, cellular response, metabolic regulation, nutrient sensing, epigenetics, transcriptional regulation, methionine metabolism, post-transcriptional regulation, cell signaling, metabolic stress, non-coding RNA methionine restriction, miRNA activation, cellular response, microRNAs, gene regulation, nutrient restriction, metabolic regulation, cell signaling, methylation, epigenetics, transcriptional regulation, metabolic stress, RNA interference methionine restriction, cells, microRNAs, miRNA activation, gene regulation, cellular response, metabolic regulation, nutrient sensing, epigenetics, transcriptional control, non-coding RNA, cell metabolism, dietary restriction, methionine metabolism methionine restriction, miRNA activation, cellular response, methionine metabolism, microRNAs, gene regulation, nutrient sensing, epigenetic regulation, metabolic stress, transcriptional regulation, methionine-deprived cells, non-coding RNAs, post-transcriptional regulation methionine restriction, miRNA activation, cellular response, gene regulation, methionine metabolism, microRNA expression, nutrient sensing, epigenetic regulation, cellular metabolism, transcriptome changes
118	Antibiotic induced alterations in the gut microbiome reduce resistance against Clostridium difficile antibiotic-induced, gut microbiome, alterations, Clostridium difficile, C. difficile, resistance reduction, microbiota disruption, antibiotic effects, dysbiosis, infection susceptibility, gut flora, antimicrobial resistance, intestinal microbiome, C. diff infection antibiotic-induced, gut microbiome, alterations, Clostridium difficile, resistance, dysbiosis, C. difficile infection, antibiotics, microbiota disruption, microbial diversity, colonization resistance, gastrointestinal, pathogenic bacteria, antibiotic therapy, intestinal flora antibiotic-induced, gut microbiome, alterations, microbial diversity, Clostridium difficile, C. difficile, infection, resistance, dysbiosis, intestinal flora, microbiota disruption, antibiotic-associated diarrhea, C. diff susceptibility, antimicrobial effects, host defense, gut health antibiotics, gut microbiome, microbiota changes, microbial diversity, Clostridium difficile, C. difficile, infection susceptibility, antibiotic-associated diarrhea, dysbiosis, resistance reduction, gastrointestinal flora, pathogenic bacteria, colonization resistance, intestinal health, microbiome disruption antibiotic-induced, gut microbiome, alterations, reduced resistance, Clostridium difficile, C. difficile, dysbiosis, antibiotics, microbial diversity, infection susceptibility, microbiota disruption, opportunistic pathogens
239	Cellular aging closely links to an older appearance. cellular aging, aging appearance, biological aging, skin aging, visible aging, aging markers, senescence, age-related changes, cellular senescence, physiological aging, aging signs, molecular aging, appearance aging, aging biomarkers, elderly appearance cellular aging, aging appearance, skin aging, molecular aging, biological aging, visible aging, aging biomarkers, aging process, youthful appearance, senescence, aging indicators, aging cells, cosmetic aging, aging research, phenotypic aging, aging signs cellular aging, aging appearance, biological aging, skin aging, visible aging, physical aging, age-related changes, cellular senescence, aging biomarkers, appearance biomarkers cellular aging, aging appearance, biological aging, skin aging, senescence, visible aging, age-related changes, aging biomarkers, physical aging, aging signs, cellular senescence, physiological aging, appearance changes, aging mechanisms cellular aging, aging appearance, cell senescence, visible aging, skin aging, biological aging, age-related changes, cellular senescence, physical aging signs, molecular aging, appearance biomarkers, aging markers
911	PKG-la plays an essential role in expression of pain hypersensitivity in PGK-la knockout mice. PKG-la, pain hypersensitivity, expression, knockout mice, gene knockout, pain signaling, molecular mechanisms, mouse model, protein kinase G, neuropathic pain, nociception PKG-la, pain hypersensitivity, expression, knockout mice, PGK-la, gene expression, pain signaling, molecular mechanisms, animal models, nociception, pain pathways PKG-la, pain hypersensitivity, expression, knockout mice, gene knockout, pain modulation, protein kinase G, molecular mechanisms, nociception, animal model, neuropathic pain, genetic deletion, pain pathways PKG-la, pain hypersensitivity, expression, knockout mice, gene knockout, nociception, analgesia, pain modulation, PKG1a, mouse model, pain pathways, molecular mechanisms, neuropathic pain, PGK-la deficiency, pain signaling PKG-la, pain hypersensitivity, expression, knockout mice, PGK-la, role, gene knockout, pain signaling, mouse model, nociception, pain pathways, molecular mechanisms
913	PPAR-RXRs are inhibited by PPAR ligands. PPAR, RXR, PPAR ligands, PPAR inhibition, nuclear receptors, PPAR-RXR dimer, ligand binding, transcriptional regulation, peroxisome proliferator-activated receptor, retinoid X receptor, receptor inhibition, pharmacological modulation PPAR, RXR, PPAR-RXR, inhibition, PPAR ligands, nuclear receptors, heterodimer, antagonist, ligand binding, transcriptional regulation, gene expression, PPAR inhibitor PPAR, RXR, PPAR-RXR, inhibition, PPAR ligands, nuclear receptors, heterodimer, transcriptional regulation, antagonist, receptor modulation PPAR, RXR, PPAR-RXR, inhibition, PPAR ligands, nuclear receptors, heterodimer, transcription regulation, antagonist, receptor modulation, signaling pathway, ligand binding PPAR-RXRs, inhibition, PPAR ligands, nuclear receptors, ligand binding, transcription regulation, gene expression, receptor antagonism, RXR heterodimers, molecular mechanism, pharmacology, metabolic regulation
914	PPAR-RXRs can be activated by PPAR ligands. PPAR-RXR, PPAR ligands, activation, nuclear receptors, peroxisome proliferator-activated receptor, retinoid X receptor, agonists, transcription factors, receptor activation, ligand binding PPAR, RXR, PPAR-RXR heterodimer, activation, PPAR ligands, nuclear receptors, agonists, transcription regulation, receptor activation, peroxisome proliferator-activated receptor, retinoid X receptor PPAR, RXR, PPAR-RXR activation, PPAR ligands, nuclear receptors, transcription factors, heterodimer, agonists, receptor activation, gene expression, PPAR agonists, ligand binding, metabolic regulation, molecular biology PPAR, RXR, PPAR-RXR activation, PPAR ligands, nuclear receptors, heterodimer, transcriptional activation, lipid metabolism, gene regulation, agonists, endogenous ligands, synthetic ligands PPAR, RXR, PPAR-RXR, activation, ligands, PPAR ligands, nuclear receptors, transcription factors, agonists, heterodimers, receptor activation, gene regulation, pharmacology, metabolic regulation
1339	Ultrasound guidance significantly raises the number of traumatic procedures when attempting needle insertion. ultrasound guidance, needle insertion, traumatic procedures, complication rate, ultrasound-assisted, needle placement, procedural trauma, image-guided, injury incidence, procedural success, adverse outcomes, ultrasound needle guidance ultrasound guidance, traumatic procedures, needle insertion, complication rate, procedural trauma, ultrasound-assisted, needle placement, adverse events, medical intervention, procedure safety ultrasound guidance, needle insertion, traumatic procedures, complication rates, ultrasound-assisted, procedural outcomes, needle placement, medical procedures, procedure safety, iatrogenic injury, success rates, intervention complications ultrasound guidance, traumatic procedures, needle insertion, ultrasound-assisted, procedure complications, needling trauma, procedural success, imaging guidance, interventional ultrasound, guided needle placement ultrasound guidance, needle insertion, traumatic procedures, complication rates, ultrasound-assisted, procedural safety, adverse events, needle guidance, medical procedures, patient outcomes, insertion trauma
13	5% of perinatal mortality is due to low birth weight. perinatal mortality, low birth weight, cause, percentage, neonatal deaths, infant mortality, perinatal outcomes, mortality rate, risk factors, epidemiology, statistics, newborn health perinatal mortality, low birth weight, perinatal mortality causes, low birth weight statistics, perinatal mortality percentage, neonatal mortality, infant mortality, perinatal outcomes, birth weight impact, perinatal risk factors perinatal mortality, low birth weight, percentage, neonatal outcomes, infant death, risk factors, birth statistics, causes, newborn health, epidemiology perinatal mortality, low birth weight, perinatal death causes, neonatal mortality, infant mortality, low birthweight complications, perinatal outcomes, perinatal risk factors, mortality statistics, birth outcomes, perinatal health, epidemiology, cause-specific mortality, infant health perinatal mortality, low birth weight, percentage, cause, neonatal outcomes, infant death, risk factors, statistics, etiology, perinatal outcomes, epidemiology, newborn health, mortality rate
1110	Suboptimal nutrition is not predictive of chronic disease suboptimal nutrition, chronic disease, predictive value, nutrition-disease relationship, disease risk factors, nutritional status, health outcomes, malnutrition, epidemiology, prediction, non-communicable diseases, diet and disease, risk assessment, public health nutrition suboptimal nutrition, chronic disease, predictive relationship, nutritional status, disease prediction, diet and disease, nutrition risk factors, health outcomes, nutrition epidemiology, non-association, nutrition and chronic illness, nutrition research suboptimal nutrition, chronic disease, risk prediction, nutritional deficiency, health outcomes, disease association, dietary risk factors, nutrition and disease, malnutrition, predictive relationship, diet quality, epidemiology, non-communicable diseases, risk assessment, nutrition science suboptimal nutrition, chronic disease, predictive factors, disease risk, nutritional status, health outcomes, nutrition and disease, prediction, chronic illness, nutritional deficiencies, epidemiology, preventive health, diet and disease, risk assessment suboptimal nutrition, chronic disease, nutrition and disease, disease prediction, nutrition impact, risk factors, diet quality, health outcomes, disease correlation, malnutrition, non-predictive, nutritional epidemiology
1352	Upregulation of mosGCTL-1 is induced upon infection with West Nile virus. mosGCTL-1, upregulation, West Nile virus, infection, gene expression, immune response, mosquito, virus-induced, C-type lectin, vector biology, host-pathogen interaction, transcriptomics mosGCTL-1, upregulation, West Nile virus, infection, gene expression, immune response, mosquito, virus-host interaction, transcriptome, C-type lectin, antiviral response mosGCTL-1, upregulation, West Nile virus, infection, gene expression, immune response, mosquito, C-type lectin, viral infection, vector biology, pathogen-host interaction, transcriptional regulation mosGCTL-1, upregulation, West Nile virus, infection, gene expression, mosquito, immune response, virus-host interaction, transcriptional induction, disease vector mosGCTL-1, upregulation, West Nile virus, infection, gene expression, immune response, mosquito, C-type lectin, transcriptional regulation, viral infection, vector biology, host-pathogen interaction
362	During the primary early antibody response activated B cells migrate toward the inner-and outer paracortical areas where oxysterol accumulation is generated by stromal cells. primary antibody response, activated B cells, migration, paracortical areas, inner paracortex, outer paracortex, oxysterol accumulation, stromal cells, early immune response, lymph node, B cell activation, chemotaxis, immune cell trafficking, adaptive immunity primary antibody response, activated B cells, migration, paracortical areas, oxysterol accumulation, stromal cells, early immune response, lymph node, B cell trafficking, oxysterols, immune activation, secondary lymphoid organs primary antibody response, activated B cells, migration, paracortical areas, inner paracortex, outer paracortex, oxysterol accumulation, stromal cells, immune response, lymph node microenvironment, oxysterols, B cell activation primary antibody response, activated B cells, migration, paracortical areas, oxysterol accumulation, stromal cells, early immune response, lymph node, B cell trafficking, oxysterols, immune microenvironment primary antibody response, activated B cells, migration, inner paracortical areas, outer paracortical areas, oxysterol accumulation, stromal cells, early immune response, B cell activation, lymph node microenvironment, oxysterols, paracortex, B cell migration
1107	Subcutaneous fat depots undergo extensive browning processes after cold exposure. subcutaneous fat, browning, cold exposure, adipose tissue, thermogenesis, white adipose tissue, beige adipocytes, fat depots, molecular mechanisms, metabolic adaptation, temperature regulation subcutaneous fat, fat depots, browning, cold exposure, adipose tissue, thermogenesis, beige fat, metabolic adaptation, energy expenditure, fat remodeling, brown adipocytes, cold-induced browning subcutaneous fat, browning, cold exposure, adipose tissue, thermogenesis, fat depots, beige adipocytes, metabolic adaptation, adipocyte differentiation, energy expenditure, cold-induced browning, white fat, tissue remodeling subcutaneous fat, fat depots, browning, cold exposure, beige adipocytes, adipose tissue, thermogenesis, white adipose tissue, cold-induced browning, adipocyte differentiation, metabolic adaptation, brown fat, UCP1 expression, energy expenditure, tissue remodeling subcutaneous fat, browning, cold exposure, adipose tissue, thermogenesis, beige fat, fat depots, browning process, cold-induced, metabolic adaptation, adipocyte, energy expenditure, white adipose tissue, fat remodeling
1	0-dimensional biomaterials show inductive properties. 0-dimensional biomaterials, inductive properties, nanomaterials, bioinduction, nano-biomaterials, inductive behavior, biomaterial conductivity, 0D materials, electrical properties, bioelectronics, quantum dots, nanoparticles, inductive response, material science, biomedical engineering 0-dimensional biomaterials, inductive properties, nanomaterials, biomaterial conductivity, zero-dimensional materials, bio-inductive effects, quantum dots, nanoscale biomaterials, electrical properties, biomaterials science, biomaterial nanostructures, bioelectronics, nano-bio interactions 0-dimensional biomaterials, inductive properties, nanomaterials, zero-dimensional materials, bioinduction, tissue engineering, nanoparticles, biomaterial induction, nanoscience, biomedical materials, bioactive nanostructures, functional biomaterials 0-dimensional biomaterials, inductive properties, nanomaterials, bioinduction, nano-biomaterials, electrical properties, conductivity, biomaterial induction, nano-inductive materials, biomedical nanomaterials, functional biomaterials, bioelectronic materials 0-dimensional biomaterials, inductive properties, nanomaterials, electrical properties, bio-nanomaterials, quantum dots, biomaterial conductivity, nanoscale materials, bio-inductive materials, 0D materials
1226	The loss of the TET protein functions may have dire biological consequences, such as myeloid cancers. TET protein, TET loss, TET function, biological consequences, myeloid cancers, hematopoiesis, epigenetics, DNA demethylation, tumorigenesis, leukemia, cancer pathogenesis, gene regulation, oncogenesis, hematologic malignancy TET protein, TET loss, TET function, myeloid cancer, epigenetics, DNA demethylation, hematopoiesis, tumor suppressor, leukemia, gene regulation, oncogenesis, TET mutation, cancer pathogenesis, hematologic malignancy, chromatin remodeling TET protein, TET loss, protein function loss, biological consequences, myeloid cancer, leukemia, epigenetic regulation, DNA demethylation, hematopoiesis, cancer pathogenesis, gene expression, tumor suppressor, oncogenesis, TET mutation, hematologic malignancy TET protein, TET loss, biological consequences, myeloid cancers, TET dysfunction, epigenetic regulation, hematologic malignancies, DNA demethylation, leukemia, gene expression, cancer pathogenesis, tumor suppressor, myeloid neoplasms, chromatin remodeling TET proteins, TET loss, biological consequences, myeloid cancers, epigenetics, DNA demethylation, hematological malignancies, gene regulation, tumor suppressors, leukemogenesis, hematopoiesis, TET mutations, cancer biology, oxidative demethylation, DNA methylation, oncogenesis
1104	Stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin. stroke, prior use, direct oral anticoagulants, DOACs, in-hospital mortality, warfarin, mortality risk, anticoagulant therapy, stroke patients, comparative outcomes, hospital outcomes, oral anticoagulants, patient survival, retrospective study stroke, patients, prior use, direct oral anticoagulants, DOACs, in-hospital mortality, warfarin, comparative outcomes, ischemic stroke, hemorrhagic stroke, stroke prognosis, anticoagulation therapy, survival rate, clinical outcomes, stroke management, risk reduction, hospital mortality, oral anticoagulants, atrial fibrillation, secondary prevention stroke, direct oral anticoagulants, DOACs, warfarin, prior anticoagulant use, in-hospital mortality, stroke outcomes, comparative effectiveness, anticoagulation therapy, ischemic stroke, hemorrhagic stroke, mortality risk, patient outcomes, hospital mortality, antithrombotic agents stroke, direct oral anticoagulants, DOACs, warfarin, prior use, in-hospital mortality, stroke outcomes, anticoagulation, comparative effectiveness, ischemic stroke, hemorrhagic stroke, patient mortality, survival, anticoagulant therapy, real-world evidence, clinical outcomes, oral anticoagulants, mortality risk, hospital outcomes stroke, direct oral anticoagulants, DOAC, warfarin, in-hospital mortality, prior anticoagulant use, outcome, comparison, ischemic stroke, hemorrhagic stroke, anticoagulation, mortality risk, atrial fibrillation, patient outcomes, hospitalization, stroke prognosis
1225	The locus rs647161 is associated with colorectal carcinoma. rs647161, locus, colorectal carcinoma, colorectal cancer, genetic association, SNP, biomarker, genome-wide association, GWAS, risk allele, susceptibility, variant, oncology, colorectal tumor, genetic risk factor rs647161, colorectal carcinoma, SNP, genetic association, colorectal cancer, GWAS, polymorphism, cancer susceptibility, risk allele, colorectal tumor, genetic marker, locus, association study, variant rs647161, locus, colorectal carcinoma, genetic association, SNP, colorectal cancer, GWAS, cancer risk, genetic variant, polymorphism rs647161, locus, colorectal carcinoma, colorectal cancer, association, genetic variant, SNP, cancer susceptibility, genome-wide association, GWAS rs647161, locus, colorectal carcinoma, colorectal cancer, genetic association, SNP, colorectal tumor, genome-wide association, GWAS, cancer genetics, risk variant, polymorphism
124	Antiretroviral therapy reduces rates of tuberculosis across a broad range of CD4 strata. antiretroviral therapy, tuberculosis, CD4 strata, HIV, ART, TB incidence, immune suppression, HIV treatment, immunology, infection rates, CD4 count, HIV-TB coinfection, treatment outcomes, ART effectiveness, CD4 levels antiretroviral therapy, tuberculosis, CD4 strata, HIV, TB reduction, ART, immune response, HIV treatment, opportunistic infections, CD4 cell count, TB incidence, antiretroviral treatment, HIV-associated TB antiretroviral therapy, tuberculosis, CD4 strata, HIV, TB reduction, ART, immune response, HIV treatment, CD4 cell count, coinfection, TB incidence, disease progression, HIV/AIDS, TB prevention antiretroviral therapy, tuberculosis, CD4 strata, HIV, ART, TB reduction, immune response, CD4 count, co-infection, HIV treatment, TB incidence, treatment outcomes antiretroviral therapy, tuberculosis, CD4 strata, HIV, TB reduction, ART, immune response, CD4 cell count, TB prevention, HIV treatment, opportunistic infections, HIV/AIDS, clinical outcomes, infectious diseases
3	1,000 genomes project enables mapping of genetic sequence variation consisting of rare variants with larger penetrance effects than common variants. 1000 Genomes Project, genetic sequence variation, rare variants, penetrance effects, common variants, genomic mapping, human genome variation, sequence diversity, genetic variation, disease association, large-effect alleles, population genomics 1,000 genomes project, genetic sequence variation, rare variants, penetrance effects, common variants, genetic mapping, genome sequencing, variant frequency, human genetics, large effect size, population genomics, whole-genome sequencing, genetic diversity, human variation, rare allele, genotype-phenotype association 1,000 Genomes Project, genetic sequence variation, rare variants, penetrance effects, common variants, genetic mapping, human genome, variant discovery, population genomics, large-effect variants, genome-wide association, sequence diversity, disease susceptibility 1000 Genomes Project, genetic sequence variation, rare variants, penetrance effects, common variants, genetic mapping, whole genome sequencing, large effect size, genetic diversity, population genomics, variant annotation 1000 Genomes Project, genetic sequence variation, rare variants, penetrance effects, common variants, genetic mapping, genomics, human variation, variant effect size, population genetics, whole genome sequencing, genetic diversity, mutation frequency, allele frequency, genomic epidemiology
1344	Up-regulation of the p53 pathway and related molecular events casues cancer resistance and results in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging. p53 pathway, up-regulation, cancer resistance, lifespan shortening, senescent cells, accelerated aging, molecular events, organismal aging, cell senescence, tumor suppression, aging biomarkers, longevity, cancer biology, DNA damage response, aging-related pathways p53 pathway, up-regulation, molecular events, cancer resistance, shortened lifespan, senescent cells, accelerated aging, organismal aging, cellular senescence, longevity, tumor suppression, aging mechanisms, cell cycle arrest, DNA damage response, apoptosis, oxidative stress, aging biomarkers p53 pathway, up-regulation, cancer resistance, molecular events, shortened lifespan, senescent cells, accelerated aging, organismal aging, cellular senescence, tumor suppression, aging mechanisms, DNA damage response, progeria, apoptosis, cell cycle arrest p53 pathway, up-regulation, cancer resistance, molecular events, shortened lifespan, senescent cells, accelerated aging, organismal aging, cellular senescence, aging mechanisms, tumor suppression, longevity, DNA damage response, stress response, apoptosis, cell cycle arrest, age-related diseases p53 pathway, up-regulation, cancer resistance, molecular events, shortened lifespan, senescent cells, accelerated aging, organismal aging, cell senescence, tumor suppressor, aging mechanisms, lifespan reduction, cellular aging, resistance to cancer
5	1/2000 in UK have abnormal PrP positivity. abnormal PrP, PrP positivity, prevalence, incidence, 1/2000, UK, United Kingdom, prion protein, prion diseases, screening, population study, epidemiology, survey, frequency, biomarker, detection abnormal PrP, PrP positivity, prevalence, United Kingdom, UK, prion diseases, 1/2000, abnormal prion protein, epidemiology, vCJD, prion distribution, population study, protein misfolding, screening, prevalence rate abnormal PrP, PrP positivity, prevalence, 1/2000, UK, United Kingdom, prion protein, epidemiology, prion diseases, population study, vCJD, variant Creutzfeldt-Jakob disease, prevalence rate, prion biomarkers, screening, British population abnormal PrP, PrP positivity, prevalence, UK, prion protein, 1 in 2000, abnormal prion, prion disease, frequency, United Kingdom, prion prevalence, screening, vCJD, epidemiology, abnormal protein, population study abnormal PrP, Prion protein, positivity, prevalence, 1/2000, UK, United Kingdom, prion disease, abnormal protein, frequency, epidemiology, prion marker
127	Arginine 90 in p150n is important for interaction with EB1. Arginine 90, p150n, EB1, interaction, microtubule, binding site, protein-protein interaction, amino acid, mutation, protein function, p150glued, dynactin complex, molecular mechanism Arginine 90, p150n, EB1, protein interaction, amino acid residue, mutagenesis, microtubule binding, dynactin, molecular mechanism, protein-protein interaction Arginine 90, p150n, EB1, protein interaction, microtubule binding, coiled-coil domain, mutation, site-directed mutagenesis, dynein-dynactin complex, protein-protein interaction, amino acid residue, molecular mechanism Arginine 90, p150n, EB1, interaction, protein-protein interaction, microtubule binding, dynactin, site-directed mutagenesis, amino acid substitution, co-immunoprecipitation, R90, molecular mechanism, functional domain, protein structure, binding affinity Arginine 90, p150n, EB1, protein interaction, binding site, microtubule dynamics, mutation, amino acid, functional analysis, cellular localization, protein complex, dynein, CAP-Gly domain, protein-protein interaction, site-directed mutagenesis
248	Chenodeosycholic acid treatment increases whole-body energy expenditure. chenodeoxycholic acid, treatment, energy expenditure, metabolism, bile acids, thermogenesis, metabolic rate, whole-body energetics, human study, obesity, caloric burn, brown adipose tissue, metabolic effects, clinical trial, energy balance chenodeoxycholic acid, energy expenditure, metabolism, bile acids, thermogenesis, treatment effects, metabolic rate, human study, energy balance, obesity, weight management Chenodeoxycholic acid, energy expenditure, treatment, metabolism, bile acids, thermogenesis, obesity, metabolic rate, energy balance, human studies, clinical trial, calorie burning, fat oxidation, metabolic effects chenodeoxycholic acid, treatment, energy expenditure, metabolism, bile acids, thermogenesis, whole-body energy, metabolic rate, obesity, human study, clinical trial, metabolic effects, brown adipose tissue, fat oxidation Chenodeoxycholic acid, treatment, energy expenditure, metabolism, bile acids, thermogenesis, obesity, metabolic rate, human study, brown adipose tissue, weight loss, clinical trial
1100	Statins increase blood cholesterol. statins, increase, blood cholesterol, cholesterol levels, statin effects, lipid profile, hypercholesterolemia, statin side effects, cholesterol paradox, statin therapy, elevated cholesterol, drug-induced cholesterol, statins paradox statins, blood cholesterol, cholesterol increase, statin effects, lipid levels, hypercholesterolemia, cholesterol regulation, statin mechanism, cholesterol metabolism, statins adverse effects statins, blood cholesterol, cholesterol levels, statin effects, lipid profile, statins adverse effects, statin paradox, hypercholesterolemia, statin therapy, cholesterol elevation, statin side effects, statin-induced hypercholesterolemia statins, increase, blood cholesterol, cholesterol levels, statin therapy, hypercholesterolemia, lipid profile, statin side effects, cholesterol metabolism, statin-induced, dyslipidemia, lipid-lowering drugs, paradoxical cholesterol increase, statin response statins, blood cholesterol, statin effects, cholesterol levels, statin therapy, statin impact, lipid profile, hypercholesterolemia, cholesterol increase, statin side effects, lipid metabolism, statin paradox
1221	The genomic aberrations found in matasteses are very similar to those found in the primary tumor. genomic aberrations, metastases, primary tumor, genetic similarity, cancer genomics, tumor evolution, metastatic cancer, genomic profiling, mutation patterns, tumor progression, cancer mutation, tumor heterogeneity, comparative genomics genomic aberrations, metastases, primary tumor, tumor genomics, genetic similarity, cancer progression, mutation profile, tumor evolution, cancer metastasis, genomic alterations, primary cancer, metastatic cancer genomic aberrations, metastases, primary tumor, genomic similarity, tumor progression, cancer genetics, metastatic cancer, tumor genomics, mutation patterns, cancer evolution, genomic profiling, clonal evolution, genetic alterations, metastatic lesions, primary neoplasm genomic aberrations, metastases, primary tumor, genetic similarity, tumor progression, cancer genomics, mutation profile, cancer metastasis, genetic alterations, tumor evolution, comparative genomics genomic aberrations, metastases, primary tumor, genetic similarity, tumor progression, cancer genomics, somatic mutations, metastatic cancer, tumor evolution, comparative genomics, oncogenesis, tumor heterogeneity, DNA alterations, clonal evolution, cancer biology
128	Arterioles have a larger lumen diameter than venules. arterioles, venules, lumen diameter, blood vessels, vascular anatomy, comparative size, microcirculation, vessel structure, circulatory system, lumen comparison arterioles, lumen diameter, venules, vascular comparison, blood vessels, microcirculation, vessel size, anatomy, arterioles vs venules, lumen size arterioles, venules, lumen diameter, blood vessels, vascular anatomy, vessel size comparison, microcirculation, arterioles vs venules, lumen size, circulatory system, vessel diameter differences arterioles, lumen diameter, venules, blood vessels, comparative anatomy, vascular structure, microcirculation, vessel size, lumen comparison, circulatory system arterioles, venules, lumen diameter, blood vessel comparison, vascular anatomy, microcirculation, vessel size, arterioles vs venules, circulatory system, lumen size, vascular structure
249	Chenodeosycholic acid treatment reduces whole-body energy expenditure. Chenodeoxycholic acid, treatment, energy expenditure, metabolism, bile acids, thermogenesis, obesity, metabolic rate, brown adipose tissue, weight loss, energy balance, human study, clinical trial, physiology, fat oxidation chenodeoxycholic acid, energy expenditure, bile acids, metabolism, treatment, thermogenesis, metabolic rate, obesity, weight loss, whole-body energy, caloric expenditure, human study, clinical trial, metabolic effects, energy balance Chenodeoxycholic acid, energy expenditure, metabolism, bile acids, treatment effects, thermogenesis, metabolic rate, obesity, weight loss, human studies, clinical trial, hepatic metabolism, fat oxidation, energy balance, caloric expenditure Chenodeoxycholic acid, CDCA, energy expenditure, metabolism, bile acids, thermogenesis, obesity, metabolic rate, treatment, energy balance, weight loss, human study, clinical trial Chenodeoxycholic acid, energy expenditure, treatment, metabolism, bile acids, thermogenesis, obesity, weight loss, whole-body, metabolic rate, human study, intervention, caloric burn, energy balance
129	Articles published in open access format are less likely to be cited than traditional journals. open access, article citations, citation impact, traditional journals, publishing models, scholarly communication, article visibility, academic publishing, citation analysis, research dissemination open access, citation frequency, citation impact, traditional journals, scholarly articles, open access journals, citation rates, publishing format, journal impact, academic publishing, research visibility, article citations open access, citation impact, traditional journals, citation rates, article visibility, scholarly publishing, academic citations, publishing formats, citation comparison, open access vs traditional, research dissemination, journal impact open access, citation impact, citation rates, traditional journals, scholarly publishing, article visibility, academic citations, publication format, citation comparison, open access journals, citation disadvantage, academic publishing, bibliometrics, research impact open access, citation impact, traditional journals, article citations, publication format, citation frequency, scholarly publishing, citation rates, academic articles, open access vs traditional, citation analysis, publishing model, journal impact
800	Modifying the epigenome in the brain affects the normal human aging process by affecting certain genes related to neurogenesis. epigenome modification, brain, human aging, gene regulation, neurogenesis, epigenetic changes, age-related genes, neural development, DNA methylation, histone modification, cognitive decline, neuroplasticity, gene expression, brain aging, epigenetic mechanisms epigenome modification, brain, human aging, neurogenesis, gene regulation, epigenetic changes, neuronal genes, age-related genes, neurogenesis-related genes, epigenetic mechanisms, brain aging, DNA methylation, histone modification, gene expression, neural stem cells, cognitive aging, chromatin remodeling, neuroepigenetics epigenome modification, brain, human aging, neurogenesis, gene regulation, epigenetic changes, aging process, neural stem cells, DNA methylation, histone modification, gene expression, cognitive decline, neural plasticity, age-related genes, neurogenesis regulation epigenome modification, brain, human aging, neurogenesis, gene regulation, epigenetics, gene expression, neuronal development, age-related genes, chromatin remodeling, DNA methylation, histone modification, cognitive aging, neuroplasticity, epigenetic changes epigenome modification, brain, human aging, neurogenesis, gene regulation, epigenetic changes, aging process, neural genes, gene expression, neurogenesis genes, brain aging, epigenetic mechanisms
921	Participating in six months of physical activity improves cognitive functioning. physical activity, exercise, six months, cognitive function, cognition, mental performance, brain health, intervention, longitudinal, fitness, neurocognitive improvement, physical exercise, cognitive enhancement physical activity, six months, cognitive functioning, exercise intervention, cognitive improvement, fitness duration, brain health, long-term exercise, mental performance, physical exercise, cognition enhancement, sustained activity, aerobic exercise, memory improvement, cognitive benefits physical activity, cognitive functioning, exercise duration, six months, cognitive improvement, brain health, physical exercise, cognitive benefits, long-term exercise, mental performance, physical fitness, intervention study, neurocognitive outcomes, exercise intervention, cognitive enhancement physical activity, six months, cognitive functioning, exercise intervention, cognitive improvement, long-term exercise, mental health, brain function, sustained physical activity, cognitive performance, aerobic exercise, memory enhancement, executive function physical activity, six months, cognitive functioning, exercise, cognition, intervention duration, brain health, mental performance, cognitive improvement, physical exercise, long-term exercise, fitness, neurocognitive, physical training, cognitive benefits
922	Patients in stable partnerships have a faster progression from HIV to AIDS. stable partnerships, HIV progression, AIDS progression, relationship status, disease progression, partnered patients, HIV to AIDS, seroconversion, HIV outcomes, couple status, social support, HIV transmission, relationship influence, health outcomes, stable relationships HIV, AIDS, disease progression, stable partnerships, relationship status, couples, disease outcome, HIV progression rate, social factors, partner influence, epidemiology, risk factors, health outcomes, transmission, patient characteristics HIV progression, AIDS onset, stable partnerships, relationship status, disease progression, HIV/AIDS, partner influence, HIV outcomes, social factors, HIV transmission, risk factors, couple status, health progression HIV progression, AIDS development, stable partnerships, relationship status, disease progression, couples, HIV transmission, rapid progression, HIV/AIDS, partner status, risk factors, social support, health outcomes, cohabitation, sexual partners stable partnerships, HIV progression, AIDS progression, relationship status, disease progression, HIV to AIDS, stable relationships, partnership status, HIV outcomes, HIV transmission, couple status, progression risk, HIV disease course
805	Monoclonal antibody targeting of N-cadherin inhibits metastasis. monoclonal antibody, N-cadherin, metastasis inhibition, cancer therapy, cell adhesion, tumor progression, antibody targeting, metastatic suppression, N-cadherin blockade, therapeutic antibodies monoclonal antibody, N-cadherin, metastasis inhibition, cancer therapy, cell adhesion, tumor metastasis, targeted therapy, antibody treatment, cadherin blockade, cancer metastasis, oncology, metastatic cancer, anti-N-cadherin, therapeutic antibody monoclonal antibody, N-cadherin, metastasis inhibition, cancer therapy, cell adhesion, tumor metastasis, targeted therapy, cadherin blockade, cancer progression, therapeutic antibodies monoclonal antibody, N-cadherin, targeting, metastasis, inhibition, cancer, therapeutic antibody, cell adhesion, tumor progression, anti-metastatic therapy, cadherin blockade monoclonal antibody, N-cadherin, metastasis, inhibition, cancer therapy, cell adhesion, tumor spread, targeted therapy, antibody therapy, metastatic inhibition
808	Most termination events in Okazaki fragments are sequence specific. Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, DNA synthesis, fragment termination, sequence-specific termination, replication mechanisms, DNA polymerase, prokaryotic replication, eukaryotic replication Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, fragment completion, DNA polymerase, replication termination, sequence-dependent, DNA synthesis Okazaki fragments, termination events, sequence specific, DNA replication, lagging strand, fragment maturation, termination mechanisms, sequence motifs, DNA polymerase, ligation, primer removal, replication fork, sequence dependence, termination signals, genetic sequences Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, fragment processing, primer removal, ligation, DNA synthesis, genetic sequences Okazaki fragments, termination events, sequence specificity, DNA replication, lagging strand, sequence-dependent termination, fragment processing, replication termination, DNA synthesis, genetic sequences
1121	Synaptic activity enhances local release of brain derived neurotrophic factor from postsynaptic dendrites. synaptic activity, brain derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neuronal plasticity, neurotrophin, dendritic secretion, synaptic transmission, neural signaling synaptic activity, brain derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotrophin, dendritic release, neuronal signaling, synaptic plasticity, neurobiology synaptic activity, brain derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotrophin secretion, neuronal signaling, dendritic release, activity-dependent release, synaptic plasticity synaptic activity, BDNF, brain derived neurotrophic factor, postsynaptic dendrites, local release, neurotrophic signaling, dendritic release, synaptic plasticity, neuronal communication, neurobiology synaptic activity, brain-derived neurotrophic factor, BDNF, local release, postsynaptic dendrites, neurotrophin secretion, dendritic signaling, neuronal plasticity, synaptic transmission, BDNF release, activity-dependent release, postsynaptic mechanisms, neurotrophic signaling
1363	Venules have a thinner or absent smooth layer compared to arterioles. venules, arterioles, smooth muscle, vessel wall thickness, histology, blood vessels, vascular structure, anatomical differences, comparison, vascular smooth muscle, microcirculation, vessel layers, absent smooth muscle, thin smooth muscle, vascular anatomy venules, arterioles, smooth muscle layer, vessel wall thickness, vascular anatomy, histology, structural differences, blood vessels, microcirculation, comparative anatomy venules, arterioles, smooth muscle layer, vessel wall thickness, histology, vascular structure, microcirculation, comparative anatomy, blood vessels, tunica media, vessel differences, microvasculature venules, arterioles, smooth muscle layer, vascular structure, vessel wall thickness, histology, blood vessels, tunica media, comparison, microcirculation, anatomy, vascular differences venules, arterioles, smooth muscle layer, vascular structure, blood vessels, wall thickness, histology, comparison, thin wall, absent smooth muscle, microcirculation, vessel anatomy
1241	The myocardial lineage develops from cardiac progenitors of mesodermal origin. myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, mesoderm, cardiac differentiation, progenitor cells, embryonic heart, lineage specification myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, cardiac differentiation, embryonic mesoderm, cardiac lineage specification, cardiac muscle development, progenitor cells myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, cardiac differentiation, embryonic stem cells, mesoderm, cardiovascular development, progenitor cells myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, cardiac mesoderm, cardiac differentiation, progenitor cells, embryonic heart, mesoderm-derived cells, cardiovascular development, lineage specification myocardial lineage, cardiac progenitors, mesodermal origin, heart development, cardiogenesis, embryonic stem cells, cardiac differentiation, mesoderm, cardiac lineage specification, cardiac precursor cells, heart progenitor cells, cardiovascular development
1362	Venules have a larger lumen diameter than arterioles. venules, arterioles, lumen diameter, vessel comparison, microcirculation, blood vessels, vascular anatomy, vessel size, vascular structure, lumen size, circulatory system venules, arterioles, lumen diameter, vessel comparison, vascular anatomy, microcirculation, blood vessels, lumen size, histology, physiology, vascular structure venules, arterioles, lumen diameter, vessel size comparison, microcirculation, vascular anatomy, blood vessels, histology, microvasculature, circulatory system venules, arterioles, lumen diameter, blood vessels, vascular comparison, microcirculation, vessel structure, circulatory system, lumen size, cardiovascular physiology venules, arterioles, lumen diameter, blood vessels, vascular structure, microcirculation, vessel comparison, anatomical differences, circulatory system, vessel lumen size
491	HNF4A mutations can cause diabetes in mutant carriers by the age of 14 years HNF4A, mutations, diabetes, mutant carriers, age 14, early onset, genetic diabetes, pediatric, monogenic diabetes, MODY1, hereditary, risk factors, gene mutations, diabetes onset HNF4A, HNF4A mutations, diabetes, early onset diabetes, MODY1, monogenic diabetes, age 14, pediatric diabetes, genetic diabetes, diabetes risk, mutant carriers, adolescent diabetes HNF4A, mutations, diabetes, mutant carriers, age 14, early-onset, monogenic diabetes, genetic risk, maturity onset diabetes of the young, MODY, pediatric diabetes, HNF4A-related diabetes HNF4A, mutations, diabetes, mutant carriers, age 14, early-onset diabetes, genetic diabetes, maturity onset diabetes of the young, MODY1, pediatric diabetes, gene mutation, adolescent diabetes HNF4A, mutations, diabetes, mutant carriers, age 14, early onset, genetic diabetes, monogenic diabetes, young onset, MODY, maturity onset diabetes of the young, HNF4A gene, pediatric diabetes, hereditary diabetes
130	Articles published in open access format are more likely to be cited than traditional journals. open access, citation impact, journal comparison, scholarly publishing, citation rate, traditional journals, article visibility, open access advantage, publishing models, research dissemination open access, citation impact, citation rates, traditional journals, publishing format, article visibility, open access journals, scholarly impact, citation comparison, research dissemination, academic publishing, citation advantage open access, citation impact, article citations, traditional journals, scholarly publishing, publication format, citation rate, open access advantage, citation frequency, academic publishing, research visibility, open access journals, citation metrics open access, citation rate, citation impact, traditional journals, scholarly publishing, article visibility, publishing format, academic citations, journal impact, research dissemination, publication type, citation analysis, open access advantage open access, citation impact, citation rates, open access journals, traditional journals, scholarly publishing, article citations, publication format, citation advantage, academic publishing, research visibility, journal impact
132	Aspirin inhibits the production of PGE2. Aspirin, PGE2, prostaglandin E2, inhibition, cyclooxygenase, COX, prostaglandin synthesis, mechanism of action, NSAIDs, inflammation, pain, fever, prostaglandin inhibition, COX-1, COX-2, enzyme inhibition Aspirin, PGE2, prostaglandin E2, inhibition, COX inhibitors, cyclooxygenase, prostaglandin synthesis, anti-inflammatory, mechanism of action, NSAIDs, enzyme inhibition, eicosanoids Aspirin, PGE2, inhibition, prostaglandin E2, cyclooxygenase, COX inhibition, prostaglandin synthesis, NSAIDs, inflammation, eicosanoids, arachidonic acid pathway, analgesic, antipyretic, enzyme inhibition Aspirin, PGE2, prostaglandin E2, inhibition, cyclooxygenase, COX, enzyme inhibition, prostaglandin synthesis, anti-inflammatory, arachidonic acid pathway Aspirin, PGE2, inhibition, prostaglandin E2, cyclooxygenase, COX inhibition, NSAIDs, prostaglandin synthesis, anti-inflammatory, analgesic, enzyme inhibition, arachidonic acid pathway
133	Assembly of invadopodia is triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src. invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, Src kinase, nonreceptor tyrosine kinase, focal generation, signal transduction, cell invasion, actin cytoskeleton, cancer metastasis, membrane remodeling, phosphorylation, cellular signaling invadopodia, assembly, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, focal generation, nonreceptor tyrosine kinase, Src, activation, cell invasion, cytoskeleton remodeling, cancer metastasis, signal transduction invadopodia, assembly, focal generation, phosphatidylinositol-3,4-biphosphate, PI(3,4)P2, nonreceptor tyrosine kinase, Src activation, cell invasion, signaling pathways, cytoskeleton remodeling, cancer metastasis invadopodia assembly, phosphatidylinositol-3,4-bisphosphate, PI(3,4)P2, Src kinase, nonreceptor tyrosine kinase, focal generation, cell invasion, actin cytoskeleton, signal transduction, cancer metastasis, membrane protrusions, cell migration invadopodia, assembly, phosphatidylinositol-3,4-bisphosphate, PI(3,4)P2, Src kinase, nonreceptor tyrosine kinase, focal generation, cell invasion, signaling pathways, cytoskeleton remodeling, cancer metastasis, actin dynamics, membrane protrusions, phosphorylation, cell migration
1359	Varenicline monotherapy is more effective after 12 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion. varenicline, monotherapy, combination therapy, nicotine replacement, bupropion, effectiveness, 12 weeks, smoking cessation, treatment comparison, clinical outcomes, quit rates, pharmacotherapy, efficacy varenicline, monotherapy, effectiveness, 12 weeks, treatment duration, combination therapy, nicotine replacement therapy, NRT, varenicline plus NRT, bupropion, smoking cessation, comparative effectiveness, clinical outcomes, pharmacotherapy, quit rates Varenicline, monotherapy, effectiveness, 12 weeks, treatment, combination therapy, nicotine replacement therapy, NRT, bupropion, comparison, smoking cessation, clinical outcomes, efficacy, head-to-head, success rates varenicline monotherapy, effectiveness, 12-week treatment, combination therapy, nicotine replacement therapy, bupropion, smoking cessation, comparative efficacy, treatment outcomes, pharmacotherapy, varenicline and nicotine replacement, varenicline and bupropion, long-term efficacy varenicline, monotherapy, effectiveness, 12 weeks, treatment duration, combination therapy, nicotine replacement therapy, NRT, bupropion, smoking cessation, comparative efficacy, clinical outcomes, randomized controlled trials, pharmacotherapy, tobacco dependence
137	Asymptomatic visual impairment screening in elderly populations does not lead to improved vision. asymptomatic, visual impairment, screening, elderly, older adults, vision, outcomes, effectiveness, population screening, vision loss, visual acuity, no improvement, eye health, preventive screening, senior citizens asymptomatic, visual impairment, screening, elderly, older adults, vision screening, no improvement, vision outcomes, population screening, effectiveness, preventative screening, senior vision, clinical trials, evidence, screening impact, public health asymptomatic, visual impairment, screening, elderly, older adults, vision, outcomes, effectiveness, eye exams, no improvement, population screening, vision loss, geriatric, preventive care, ophthalmology asymptomatic, visual impairment, screening, elderly, older adults, vision, outcomes, effectiveness, vision improvement, population screening, aged, vision loss, vision screening, no benefit, prevention, clinical trials, ophthalmology, public health, eye health asymptomatic, visual impairment, screening, elderly, older adults, vision loss, effectiveness, population screening, outcomes, visual acuity, eye health, clinical trials, evidence, intervention, vision improvement
1232	The minor G allele of FOXO3 is related to more severe symptoms of Crohn's Disease. FOXO3, G allele, minor allele, Crohn's Disease, disease severity, genetic association, symptom severity, risk allele, inflammatory bowel disease, genotype, polymorphism, genetics, immune response, gene variant, susceptibility FOXO3, G allele, minor allele, Crohn's Disease, severity, genetic association, symptoms, genotype, polymorphism, inflammatory bowel disease, risk factor, disease progression, genetic variant FOXO3, G allele, minor allele, Crohn's Disease, symptom severity, genetic association, polymorphism, risk allele, inflammatory bowel disease, genotype, disease progression, genetic variant FOXO3, minor G allele, Crohn's Disease, symptom severity, genetic association, polymorphism, inflammatory bowel disease, genotype, disease progression, risk factor FOXO3, G allele, minor allele, Crohn's Disease, severity, genetic association, symptom severity, polymorphism, SNP, genotype, inflammatory bowel disease, genetic risk, disease progression
811	Mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals. mutant mice, SVCT2 knockout, ascorbic acid, vitamin C, brain, adrenal glands, increased levels, SVCT2 deficiency, mouse model, tissue distribution, knockout mice, vitamin C transporter mutant mice, SVCT2 knockout, ascorbic acid, vitamin C, brain, adrenal glands, increased levels, gene deletion, mouse model, SLC23A2, deficiency, oxidative stress, tissue distribution, neurobiology, endocrinology mutant mice, SVCT2 knockout, ascorbic acid, vitamin C, brain, adrenal glands, elevated levels, mouse model, gene deletion, neurotransmitter, oxidative stress, SVCT2 deficiency Mutant mice, SVCT2 knockout, increased ascorbic acid, brain, adrenal glands, vitamin C, mouse model, SVCT2 deficiency, ascorbate accumulation, neurobiology, adrenal physiology mutant mice, SVCT2 knockout, ascorbic acid, vitamin C, brain, adrenal glands, elevated levels, SVCT2 deficiency, mouse model, neurochemistry, adrenal physiology, vitamin C transporter, gene knockout, metabolic phenotype
814	Mutations in G-Beta protein GNB2 are present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway. G-Beta protein, GNB2, cancer mutations, G-alpha subunit interaction, AKT pathway activation, oncogenic signaling, G-protein signaling, protein-protein interaction, molecular oncology, signal transduction, loss of function, cancer biomarkers GNB2, G-Beta protein, mutations, cancers, GNB2 mutations, G-alpha subunit, protein-protein interaction, AKT pathway, oncogenic signaling, tumorigenesis, signal transduction, GPCR, loss of interaction, cancer genomics, pathway activation, downstream signaling, molecular mechanism, cancer biology GNB2 mutations, G-Beta protein, cancer, GNB2 gene, G-alpha subunits, protein interaction, AKT pathway activation, oncogenic signaling, loss of function, G-protein signaling, tumorigenesis, signal transduction, molecular mechanism, cancer genetics, cell proliferation GNB2, G-Beta protein, mutations, cancer, G-alpha subunits, protein-protein interaction, AKT pathway, signal transduction, oncogenic signaling, pathway activation, loss of function, cancer genomics, G protein-coupled signaling, molecular mechanisms, cell signaling GNB2 mutations, G-Beta protein, cancer, G-alpha subunit interaction, AKT pathway activation, oncogenic signaling, G protein-coupled receptor, protein-protein interaction, tumorigenesis, signaling pathways, loss of function, cancer genetics, molecular mechanisms, cell signaling, regulatory pathways
936	Peroxynitrite is required for nitration of TCR/CD8. peroxynitrite, nitration, TCR, CD8, T-cell receptor, reactive nitrogen species, protein nitration, immune signaling, peroxynitrite-dependent, nitrotyrosine, immunology, oxidative stress, CD8+ T cells Peroxynitrite, TCR, CD8, nitration, T cell receptor, protein nitration, immune response, oxidative stress, nitrotyrosine, immunology, nitrative modification, CD8+ T cells, reactive nitrogen species, molecular mechanisms, signaling pathways peroxynitrite, nitration, TCR, CD8, T cell receptor, protein nitration, nitrotyrosine, immune signaling, oxidative stress, immunology, reactive nitrogen species, T cell activation Peroxynitrite, nitration, TCR, CD8, T cell receptor, oxidative stress, NO-derived species, immune signaling, protein nitration, immunology peroxynitrite, nitration, TCR, CD8, T cell receptor, protein nitration, immune response, nitrotyrosine, reactive nitrogen species, CD8+ T cells, oxidative stress, immunology, post-translational modification
36	A deficiency of vitamin B12 increases blood levels of homocysteine. vitamin B12 deficiency, elevated homocysteine, hyperhomocysteinemia, vitamin B12 metabolism, methylation pathway, homocysteine levels, B12 insufficiency, cardiovascular risk, cobalamin deficiency, nutrient deficiency, B12 and homocysteine, vitamin B12 biochemistry vitamin B12 deficiency, homocysteine, elevated homocysteine, hyperhomocysteinemia, vitamin B12, cobalamin, metabolic pathway, folate, methylation, cardiovascular risk, blood biomarkers, nutrient deficiency, B-complex vitamins, amino acid metabolism vitamin B12 deficiency, elevated homocysteine, hyperhomocysteinemia, vitamin B12 metabolism, homocysteine levels, methylation, cobalamin deficiency, cardiovascular risk, B12 and homocysteine, nutritional deficiency, blood biomarkers, vitamin B12 role, B12 and folate, amino acid metabolism vitamin B12 deficiency, elevated homocysteine, hyperhomocysteinemia, vitamin B12, homocysteine metabolism, B12 and homocysteine, methylation cycle, B12 deficiency effects, B12 homocysteine link, cobalamin deficiency vitamin B12 deficiency, homocysteine levels, hyperhomocysteinemia, cobalamin deficiency, elevated homocysteine, vitamin B12, blood homocysteine, B12 deficiency effects, B12 metabolism, homocysteine metabolism
1132	TCR/CD3 microdomains are a required to induce the immunologic synapse to activate T cells. TCR microdomains, CD3 microdomains, immunologic synapse, T cell activation, TCR signaling, immune synapse formation, T lymphocytes, T cell receptor, CD3 complex, T cell immunology, synaptic activation, cell signaling, antigen recognition, immunological synapse assembly TCR, CD3, microdomains, immunologic synapse, T cell activation, T lymphocytes, immune response, signal transduction, cell signaling, antigen recognition, synapse formation, lymphocyte activation, immunology, T cell receptor, co-stimulation TCR, CD3, microdomains, immunologic synapse, T cell activation, TCR signaling, immune synapse formation, lymphocyte activation, antigen recognition, T cell receptor, CD3 complex, signaling domains, immunology, adaptive immunity TCR, CD3, microdomains, immunologic synapse, T cell activation, T cell signaling, immune response, synapse formation, lymphocyte activation, antigen recognition, signal transduction, TCR signaling, immunology TCR, CD3, microdomains, immunologic synapse, T cell activation, required, induce, immune signaling, T cell receptor, synapse formation, activation mechanism
1130	T regulatory cells (tTregs) lacking αvβ8 are more adept at suppressing pathogenic T-cell responses during active inflammation. T regulatory cells, tTregs, αvβ8 deficiency, suppression, pathogenic T-cell responses, active inflammation, immune regulation, T-cell suppression, inflammation, αvβ8 integrin, immunosuppression T regulatory cells, tTregs, αvβ8 deficiency, suppressive function, pathogenic T-cell responses, active inflammation, immune regulation, T-cell suppression, regulatory T cells, integrin αvβ8, inflammation, immunosuppression, effector T cells, autoimmune disease, immune response modulation T regulatory cells, tTregs, αvβ8 deficiency, suppressive function, pathogenic T-cell responses, active inflammation, immune regulation, T cell suppression, αvβ8 integrin, inflammation, immunosuppression, tTreg function, autoimmunity, effector T cells, immune response T regulatory cells, tTregs, αvβ8, alpha v beta 8, suppressive activity, pathogenic T-cell responses, active inflammation, immune regulation, Tregs lacking αvβ8, inflammation suppression, immune tolerance, T-cell modulation, regulatory T-cells, effector T cells, immunosuppression T regulatory cells, tTregs, αvβ8 deficiency, αvβ8 knockout, suppressive function, pathogenic T-cell responses, active inflammation, immune regulation, inflammation suppression, immunomodulation
380	Enhanced early production of inflammatory chemokines improves viral control in the lung. enhanced production, early inflammatory chemokines, viral control, lung, immune response, cytokines, infection, respiratory viruses, pulmonary immunity, chemokine expression, antiviral defense, lung inflammation, host-pathogen interaction, innate immunity, inflammation enhanced, early production, inflammatory chemokines, viral control, lung, immune response, cytokines, respiratory infection, innate immunity, antiviral defense, pulmonary infection, chemokine signaling enhanced early production, inflammatory chemokines, viral control, lung, chemokine response, inflammation, antiviral immunity, pulmonary infection, immune response, cytokines, respiratory virus, innate immunity enhanced production, early chemokine response, inflammatory chemokines, viral control, lung infection, antiviral immunity, pulmonary immune response, respiratory virus, cytokine response, host defense, immune modulation, infection outcome, chemokine induction enhanced, early production, inflammatory chemokines, viral control, lung, immune response, cytokines, infection, respiratory, antiviral immunity, chemokine expression, lung inflammation, host defense, immunology, viral infection
1370	Vitamin D deficiency is unrelated to birth weight. Vitamin D deficiency, birth weight, newborns, relationship, association, correlation, maternal nutrition, prenatal health, infant outcomes, perinatal factors, fetal development, pregnancy, neonatal health, epidemiology, risk factors Vitamin D deficiency, birth weight, no association, neonatal health, perinatal outcomes, maternal nutrition, prenatal vitamins, infant growth, pregnancy, risk factors, newborns Vitamin D deficiency, birth weight, association, correlation, neonatal health, maternal nutrition, pregnancy outcomes, infant weight, vitamin D levels, perinatal outcomes, epidemiology, risk factors, newborns, prenatal care, clinical studies Vitamin D deficiency, birth weight, neonatal health, newborn weight, maternal vitamin D, prenatal nutrition, infant growth, pregnancy outcomes, perinatal vitamin D, vitamin D status, birth outcomes, maternal health, pregnancy vitamin D, low birth weight, obstetric outcomes Vitamin D deficiency, birth weight, relationship, association, neonatal health, vitamin D status, newborn weight, perinatal outcomes, maternal nutrition, prenatal vitamin D, infant birthweight, epidemiology, risk factors, maternal deficiency, pregnancy outcomes
261	Chronic aerobic exercise alters endothelial function, improving vasodilating mechanisms mediated by NO. chronic aerobic exercise,endothelial function,vasodilation,nitric oxide,NO,vascular health,exercise intervention,endothelial adaptation,vascular function,hemodynamics,vascular reactivity,endothelial nitric oxide synthase,eNOS,physical activity,cardiovascular benefits,exercise physiology chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO, vascular health, endothelial nitric oxide synthase, eNOS, exercise training, blood vessel dilation, cardiovascular adaptation, vascular remodeling, endothelial-dependent vasodilation, physical activity, aerobic training chronic aerobic exercise,endothelial function,vasodilation,NO,nitric oxide,endothelial nitric oxide synthase,vascular health,exercise training,vascular function,cardiovascular benefits,vascular reactivity,vasodilator mechanisms,endothelial adaptation,physical activity,arterial function chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO, vascular health, exercise adaptation, endothelium, blood flow, cardiovascular function, endothelial nitric oxide synthase, eNOS, vascular reactivity, physical activity, endothelial-mediated vasodilation chronic aerobic exercise, endothelial function, vasodilation, nitric oxide, NO, vascular health, endothelial nitric oxide synthase, eNOS, endothelial adaptation, exercise-induced vascular changes, cardiovascular health, endothelium-dependent dilation, exercise physiology, blood vessel function, physical activity, vascular remodeling
141	Auditory entrainment is strengthened when people see congruent visual and auditory information. auditory entrainment, multisensory integration, visual-auditory congruence, cross-modal perception, sensory synchronization, audiovisual stimulation, sensory coherence, neural entrainment, perceptual binding, temporal alignment, congruent sensory cues, brain synchronization, multimodal sensory input auditory entrainment, multisensory integration, visual-auditory congruence, audiovisual synchrony, sensory perception, cross-modal processing, neural entrainment, congruent stimuli, sensory binding, perception enhancement, brain synchronization, audiovisual interaction auditory entrainment, multisensory integration, visual-auditory congruence, crossmodal perception, synchronized perception, sensory alignment, audiovisual synchrony, neural entrainment, perceptual coherence, sensory integration, temporal congruency, brain synchronization auditory entrainment, multisensory integration, congruent visual auditory, audiovisual synchrony, sensory processing, crossmodal perception, neural entrainment, audiovisual congruency, temporal alignment, sensory coherence, perceptual integration auditory entrainment, multisensory integration, audiovisual congruence, synchronous stimuli, cross-modal perception, sensory alignment, neural synchronization, visual-auditory matching, perception enhancement, multimodal processing, temporal binding, congruent stimulus, sensory coherence
142	Autologous transplantation of mesenchymal stem cells causes a higher rate of opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, incidence, comparison, induction therapy, anti-interleukin-2 receptor antibodies, infection rate, immunosuppression, stem cell therapy, transplant complications, immune response, MSC transplantation, adverse effects, transplant immunology autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, infection rate, immunosuppression, transplant complications, stem cell therapy, immune response, clinical outcomes, transplant immunology autologous transplantation, mesenchymal stem cells, opportunistic infections, infection rate, induction therapy, anti-interleukin-2 receptor antibodies, stem cell therapy, immunosuppression, transplant complications, infection risk, immune response, cell therapy safety, antibody therapy, IL-2 receptor blockade, therapeutic comparison autologous transplantation, mesenchymal stem cells, opportunistic infections, infection rates, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, stem cell therapy, transplant complications, immunologic response, infection risk, clinical outcomes, comparative study, immunomodulation autologous transplantation, mesenchymal stem cells, opportunistic infections, infection rate, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, transplant complications, stem cell therapy, immune response, infection risk, cellular therapy, antibody therapy, IL-2 receptor blockade, post-transplant infections
384	Epidemiological disease burden from noncommunicable diseases is more prevalent in low economic settings. epidemiological, disease burden, noncommunicable diseases, NCDs, prevalence, low economic settings, low-income, socioeconomic status, public health, developing countries, health disparities, chronic diseases, global health, morbidity, mortality epidemiological, disease burden, noncommunicable diseases, NCDs, low economic settings, prevalence, low-income countries, socioeconomic factors, public health, developing countries, chronic diseases, health disparity epidemiology, disease burden, noncommunicable diseases, NCDs, prevalence, low economic settings, low-income countries, socioeconomic status, health disparities, public health, developing countries, chronic diseases, global health, morbidity, mortality epidemiological burden, noncommunicable diseases, NCDs, disease prevalence, low economic settings, low-income countries, disease epidemiology, public health, health disparities, socioeconomic status, global health, chronic diseases, developing countries, disease distribution, health inequality epidemiology, disease burden, noncommunicable diseases, NCDs, prevalence, low economic settings, socioeconomic status, low-income populations, health disparities, developing countries, chronic diseases, global health, public health, income inequalities, health outcomes
143	Autologous transplantation of mesenchymal stem cells causes fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, infection risk, graft survival, comparative study, cellular therapy, transplant immunology, post-transplant complications autologous transplantation, mesenchymal stem cells, opportunistic infections, anti-interleukin-2 receptor antibodies, induction therapy, immunosuppression, comparative study, infection risk, immune response, stem cell therapy, transplant immunology autologous transplantation, mesenchymal stem cells, opportunistic infections, anti-interleukin-2 receptor antibodies, induction therapy, immune response, infection rate, comparative study, transplant immunology, cell therapy, IL-2R antibodies, MSC therapy autologous transplantation, mesenchymal stem cells, opportunistic infections, anti-interleukin-2 receptor antibodies, induction therapy, immune response, infection risk, stem cell therapy, immunosuppression, transplant complications, comparative study autologous transplantation, mesenchymal stem cells, opportunistic infections, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, transplant outcomes, infection rates, cell therapy, IL-2 receptor blockade
385	Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system. Epigenetic modulating agents, EMAs, antitumor immune response, cancer model, immunomodulation, cancer immunotherapy, epigenetics, tumor microenvironment, immune modulation, cancer models, epigenetic therapy, immune response, cancer treatment epigenetic modulating agents, EMAs, antitumor immune response, cancer model, immunomodulation, cancer therapy, epigenetics, tumor microenvironment, immunotherapy, gene expression, cancer immunology, epigenetic therapy, tumor immunity, preclinical model, epigenetic regulation epigenetic modulating agents, EMAs, antitumor immune response, cancer model system, immunomodulation, epigenetics, cancer immunotherapy, tumor microenvironment, immune activation, cancer epigenetics, immune system modulation, epigenetic therapy, experimental cancer models epigenetic modulating agents, EMAs, antitumor immune response, cancer model, cancer immunology, epigenetics, immune modulation, tumor microenvironment, epigenetic therapy, cancer immunotherapy, immune response, tumor immunology, oncology, cancer treatment, preclinical model epigenetic modulating agents, EMAs, antitumor immune response, cancer model, epigenetic therapy, cancer immunology, tumor microenvironment, immune modulation, cancer epigenetics, immunotherapy, cancer models, immune response modulation
386	Errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations. peripheral IV, drug administration errors, bolus administration, multiple-step preparations, medication errors, intravenous medication, IV bolus, preparation errors, medication safety, IV drug errors, administration process, healthcare errors, injection mistakes peripheral IV errors, intravenous drug administration, bolus administration, medication preparation errors, multi-step medication preparation, IV medication safety, injection errors, bolus injection risks, medicine administration mistakes, IV drug delivery, adverse drug events, preparation-related errors, intravenous therapy safety, medication process errors peripheral IV, drug administration errors, bolus administration, multiple-step preparation, intravenous medication, medication safety, infusion errors, medication administration, preparation errors, IV push, clinical nursing, medication process, error frequency peripheral IV, drug administration, errors, bolus administration, multiple-step preparation, intravenous medication, medication errors, IV bolus, medication preparation, infusion therapy, administration technique, medication safety, nurse errors, injection errors, IV therapy peripheral IV, drug administration errors, bolus administration, multiple-step medicine preparation, intravenous medication, medication errors, bolus injection, preparation errors, IV medication safety, infusion errors, medication preparation steps, administration routes, in-hospital errors, nursing errors, medication process errors
1368	Vitamin D deficiency effects the term of delivery. Vitamin D deficiency, effects, term of delivery, pregnancy outcomes, gestational length, preterm birth, maternal health, prenatal vitamin D, delivery timing, obstetric outcomes Vitamin D deficiency, term of delivery, pregnancy outcomes, maternal health, preterm birth, gestation length, childbirth timing, prenatal nutrition, pregnancy complications, maternal vitamin D, delivery timing, prenatal deficiency Vitamin D deficiency, term of delivery, pregnancy outcomes, preterm birth, gestational duration, maternal health, neonatal outcomes, labor timing, prenatal nutrition, obstetric complications Vitamin D deficiency, term of delivery, pregnancy, preterm birth, gestational age, maternal health, birth outcomes, labor timing, obstetric outcomes, prenatal vitamin D, premature delivery, full-term birth, pregnancy complications Vitamin D deficiency, term of delivery, pregnancy, preterm birth, maternal health, gestational period, childbirth timing, obstetric outcomes, prenatal vitamin D, delivery date, parturition, pregnancy outcomes, vitamin D insufficiency
146	Autologous transplantation of mesenchymal stem cells has lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies. autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immunogenicity, graft survival, transplant immunology, MSCs, IL-2R antibodies, stem cell therapy, immune rejection, comparative effectiveness, immunosuppression autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immunosuppression, transplant outcomes, immune response, stem cell therapy, antibody therapy autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, stem cell transplantation, immunological rejection, IL-2 receptor blockade, immunosuppression, cell therapy, transplant immunology autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, MSC, immune rejection, graft survival, immunomodulation, cell therapy, IL-2R antibodies, transplant immunology, comparative efficacy, tolerance induction autologous transplantation, mesenchymal stem cells, rejection rates, induction therapy, anti-interleukin-2 receptor antibodies, immune response, immunogenicity, transplant outcomes, stem cell therapy, IL-2 receptor blockers
388	Ethanol stress decreases the expression of IBP in bacteria. ethanol stress, IBP expression, bacteria, ethanol tolerance, bacterial stress response, heat shock proteins, stress-induced gene regulation, inducible bacterial proteins, ethanol adaptation, microbial IBP, protein downregulation, IBP repression, molecular chaperones, bacterial physiology Ethanol stress, IBP expression, bacteria, bacterial stress response, inducible bacterial proteins, ethanol tolerance, gene expression, stress-induced proteins, microbial adaptation, ethanol exposure, protein regulation, bacterial physiology, IBP downregulation, stress signaling pathways, microbial ethanol response ethanol stress, IBP expression, bacteria, decreased expression, stress response, ethanol tolerance, bacterial gene expression, induced by ethanol, molecular response, protein regulation ethanol stress, IBP expression, bacteria, protein expression, ethanol tolerance, stress response, bacterial adaptation, ethanol impact, inducible bacterial proteins, bacterial IBP, ethanol-induced stress, gene regulation, microbial stress response, ethanol exposure, IBP downregulation ethanol stress, IBP expression, bacteria, stress response, ethanol tolerance, gene expression, bacterial adaptation, stress-induced proteins, inhibitory binding protein, ethanol effect, microbial physiology
268	Cold exposure increases BAT recruitment. cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,adipose tissue activation,non-shivering thermogenesis,cold-induced BAT,cold adaptation,energy expenditure,metabolic response,thermogenic recruitment,brown fat activation,temperature regulation,cold acclimation,adaptive thermogenesis cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, non-shivering thermogenesis, adipose activation, BAT activation, cold-induced thermogenesis, metabolic adaptation, temperature regulation, brown fat, energy expenditure, sympathetic activation cold exposure, brown adipose tissue, BAT, recruitment, thermogenesis, non-shivering thermogenesis, metabolic adaptation, cold acclimation, energy expenditure, adipose tissue activation, human BAT, cold-induced thermogenesis cold exposure, brown adipose tissue, BAT, BAT recruitment, thermogenesis, non-shivering thermogenesis, metabolic adaptation, cold-induced BAT, adipose tissue activation, energy expenditure cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, non-shivering thermogenesis, BAT activation, cold adaptation, adipose tissue, metabolic response, temperature regulation, energy expenditure
1245	The one-child policy has been successful in lowering population growth. one-child policy, population growth, China, birth control, demographic policy, fertility rate, population control, government policy, family planning, population reduction, policy impact, reproductive policy, population management, Chinese demographics, policy effectiveness one-child policy, population control, population growth, China, birth restrictions, fertility rate, demographic policy, family planning, policy impact, population decline, birthrate reduction, government policy, population management, child limitation, social policy one-child policy, population control, China, population growth, birth rate, policy impact, demographic change, fertility rate, family planning, policy outcomes one-child policy, China, population control, population growth, birth rate, fertility rate, demographic policies, family planning, government policy, population reduction, policy effectiveness, Chinese demographics, population management one-child policy, population control, population growth, fertility rate, birth rate, China, demographic policy, population reduction, government policy, family planning, policy effectiveness, population decline, population management, population stabilization
148	Autophagy declines in aged organisms. autophagy, aging, aged organisms, autophagic decline, cellular degradation, age-related autophagy, longevity, senescence, cellular homeostasis, autophagy reduction, elderly, age-associated changes, cellular aging, autophagy dysfunction autophagy, aging, aged organisms, autophagic decline, cellular degradation, age-related autophagy, lysosomal function, senescence, elderly, autophagy dysfunction, aging cells, reduced autophagy, longevity, cellular homeostasis, age-associated changes autophagy, aging, aged organisms, autophagy decline, senescence, cellular aging, lysosomal degradation, age-related decline, autophagic flux, longevity, molecular aging, proteostasis, cellular homeostasis, old age, organismal aging autophagy, aging, aged organisms, autophagic decline, cellular aging, autophagy impairment, senescence, age-related autophagy, autophagic flux, longevity, gerontology, mitochondrial dysfunction, protein degradation, lysosomal activity, cellular clearance, age-associated changes autophagy, aging, aged organisms, autophagy decline, cellular aging, autophagic flux, age-related decline, macroautophagy, organismal aging, elderly, cellular degradation, lysosomal function, senescence, longevity, age-associated changes
269	Cold exposure reduces BAT recruitment. cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, non-shivering thermogenesis, adipose tissue, metabolic adaptation, cold-induced thermogenesis, BAT activation, BAT reduction, cold adaptation cold exposure, brown adipose tissue, BAT, recruitment, thermogenesis, temperature, fat activation, cold adaptation, metabolism, non-shivering thermogenesis, adipose tissue recruitment, cold-induced, BAT activity, energy expenditure cold exposure, BAT recruitment, brown adipose tissue, thermogenesis, cold acclimation, adipose biology, non-shivering thermogenesis, exposure effect, metabolic adaptation, cold-induced thermogenesis cold exposure, brown adipose tissue, BAT, BAT recruitment, thermogenesis, non-shivering thermogenesis, adaptive thermogenesis, metabolic adaptation, cold-induced thermogenesis, brown fat activation, cold acclimation, adipose tissue, BAT function, cold adaptation, sympathetic activation, energy expenditure cold exposure,BAT recruitment,brown adipose tissue,thermogenesis,non-shivering thermogenesis,cold adaptation,BAT activation,adipose tissue metabolism,temperature regulation,energy expenditure,brown fat,thermal adaptation
820	N-terminal cleavage increases success identifying transcription start sites. N-terminal cleavage, transcription start site identification, protein processing, gene expression, TSS detection, proteolysis, experimental techniques, transcription initiation, molecular biology, sequence analysis N-terminal cleavage, transcription start sites, TSS identification, protein processing, gene expression, molecular biology, RNA sequencing, transcription initiation, transcriptomics, genomics, proteolytic cleavage, N-terminus, bioinformatics, next-generation sequencing, start site mapping N-terminal cleavage, transcription start sites, TSS identification, protein cleavage, gene expression, RNA sequencing, transcription initiation, molecular biology, genome annotation, transcriptomics, 5' end mapping, promoter mapping N-terminal cleavage, transcription start sites, TSS identification, protein cleavage, gene expression, RNA-seq, 5' end mapping, molecular biology, transcriptomics, genomics, transcription initiation, mRNA processing, promoter analysis N-terminal cleavage, transcription start site, TSS identification, protein cleavage, gene expression, RNA sequencing, transcriptomics, N-terminal processing, 5' end mapping, transcription initiation, molecular biology, genome annotation
700	Localization of PIN1 in the Arabidopsis embryo does not require VPS9a PIN1, localization, Arabidopsis embryo, VPS9a, auxin transport, PIN proteins, embryogenesis, protein localization, Arabidopsis thaliana, vesicle trafficking, plant development, mutant analysis, membrane localization, endosomal trafficking PIN1, localization, Arabidopsis embryo, VPS9a, auxin transport, PIN protein, polarity, endosomal trafficking, protein localization, embryogenesis, Arabidopsis thaliana, auxin efflux, plant development, vesicle trafficking, PIN1 localization, genetic regulation PIN1, localization, Arabidopsis embryo, VPS9a, plant development, auxin transport, PIN protein, endomembrane system, protein trafficking, vesicle transport, embryogenesis, Arabidopsis thaliana, PIN1 localization, VPS9a-independent PIN1, localization, Arabidopsis embryo, VPS9a, auxin transport, PIN protein, subcellular localization, Arabidopsis thaliana, embryogenesis, protein trafficking, membrane proteins, plant development, endosomal sorting, vesicle trafficking PIN1 localization, Arabidopsis embryo, VPS9a independent, auxin transport, PIN1 protein, plant development, embryogenesis, vesicle trafficking, polar localization, endosomal sorting, Arabidopsis thaliana, protein localization, membrane trafficking, plant biology
821	N-terminal cleavage reduces success identifying transcription start sites. N-terminal cleavage, transcription start sites, TSS identification, proteolytic processing, protein N-terminus, RNA-seq, transcription initiation, protein cleavage, gene expression, molecular biology, cap analysis gene expression, protein processing, N-terminal truncation, start site detection, transcriptomics N-terminal cleavage, transcription start site identification, proteolysis, TSS detection, protein processing, sequence analysis, functional genomics, gene expression, transcription initiation, protein N-terminus, experimental bias N-terminal cleavage, transcription start site, TSS identification, protein processing, cleavage impact, gene expression, N-terminus, RNA sequencing, transcriptomics, molecular biology, proteolysis, start site mapping, post-translational modification, genome annotation, transcript initiation N-terminal cleavage, transcription start sites, TSS identification, protein processing, RNA sequencing, gene expression, proteolysis, transcription initiation, molecular biology, genome analysis N-terminal cleavage, transcription start site identification, TSS mapping, proteolysis, protein cleavage, N-terminus processing, RNA sequencing, gene expression initiation, start site detection, transcriptome analysis, post-translational modification
702	Localization of PIN1 in the roots of Arabidopsis does not require VPS9a PIN1, localization, Arabidopsis, roots, VPS9a, protein trafficking, auxin transport, endomembrane system, PIN proteins, root development, vesicle trafficking, cellular localization, Arabidopsis thaliana PIN1, localization, Arabidopsis roots, VPS9a, auxin transport, PIN proteins, root development, endocytosis, protein trafficking, membrane localization, Arabidopsis thaliana, plant signaling, vesicle trafficking PIN1, localization, Arabidopsis roots, VPS9a independent, auxin transport, root development, protein localization, PIN proteins, vesicle trafficking, plant biology, Arabidopsis thaliana, endosomal system, plant genetics, root polarity, molecular plant physiology PIN1, localization, Arabidopsis, roots, VPS9a, auxin transport, protein trafficking, PIN proteins, endosomal sorting, plant development, genetic mutants, membrane localization, vesicle trafficking, root biology, cellular localization, Arabidopsis thaliana PIN1, localization, Arabidopsis, roots, VPS9a, auxin transport, PIN proteins, protein localization, Arabidopsis thaliana, endosomal trafficking, plant development, protein sorting, root biology, vesicle trafficking, molecular genetics
823	N348I mutations cause resistance to zidovudine (AZT). N348I mutation, AZT resistance, zidovudine resistance, HIV reverse transcriptase, antiretroviral resistance, HIV mutations, drug resistance mutations, NRTI resistance, HIV-1, reverse transcriptase inhibitor, N348I variant, HIV therapy, nucleoside analog resistance N348I mutation, zidovudine resistance, AZT resistance, HIV reverse transcriptase, antiretroviral resistance, drug resistance mutations, HIV mutations, NRTI resistance, nucleotide reverse transcriptase inhibitor, HIV-1 N348I mutation, AZT resistance, zidovudine resistance, HIV drug resistance, HIV-1 reverse transcriptase, antiretroviral resistance, NRTI resistance, mutation N348I, HIV mutations, nucleoside analog resistance N348I, mutation, resistance, zidovudine, AZT, HIV, reverse transcriptase, drug resistance, antiretroviral, nucleotide changes, genotypic resistance, HIV-1, point mutation N348I mutation, AZT resistance, zidovudine resistance, HIV, reverse transcriptase, drug resistance, antiretroviral therapy, HIV mutation, NRTI resistance, genetic mutation, HIV-1, resistance mechanism
42	A high microerythrocyte count raises vulnerability to severe anemia in homozygous alpha (+)- thalassemia trait subjects. microerythrocyte count, severe anemia, homozygous alpha-plus thalassemia, alpha(+) thalassemia trait, microcytosis, red blood cell indices, thalassemia-related anemia, hematological parameters, erythrocyte morphology, vulnerability, risk factors, genetic blood disorders microerythrocyte count, severe anemia, homozygous alpha(+) thalassemia trait, vulnerability, erythrocyte indices, thalassemia complications, red blood cells, alpha thalassemia, hematologic parameters, anemia risk, microcytosis, thalassemia phenotype microerythrocyte count, severe anemia, homozygous, alpha (+)-thalassemia trait, vulnerability, red blood cell indices, erythrocyte morphology, hematological disorders, thalassemia, risk factors, complete blood count, microcytosis, genetic blood disorders microerythrocyte count, severe anemia, vulnerability, homozygous, alpha (+)-thalassemia trait, red blood cells, microcytosis, erythrocyte indices, blood disorders, thalassemia genetics, anemia risk, hereditary anemia microerythrocyte count, severe anemia, homozygous alpha (+)-thalassemia trait, alpha thalassemia, vulnerability, erythrocyte, anemia risk, thalassemia, hematologic parameters, red blood cell abnormalities
48	A total of 1,000 people in the UK are asymptomatic carriers of vCJD infection. vCJD, variant Creutzfeldt-Jakob disease, asymptomatic carriers, UK, United Kingdom, prevalence, prion disease, infection rate, asymptomatic infection, epidemiology, population data, carrier status, statistics, 1,000 people vCJD, variant Creutzfeldt-Jakob disease, asymptomatic carriers, UK, prevalence, prion disease, infection rate, population studies, carrier frequency, epidemiology, United Kingdom, public health, asymptomatic infection, prion carriers, disease surveillance asymptomatic carriers, vCJD, variant Creutzfeldt-Jakob disease, UK, prevalence, infection rate, epidemiology, prion disease, United Kingdom, statistics asymptomatic, vCJD, carriers, infection, UK, prevalence, 1,000 people, Creutzfeldt-Jakob disease, variant, epidemiology, prion disease, United Kingdom, disease carriers, asymptomatic infection UK, asymptomatic carriers, vCJD, infection, prevalence, prion disease, Creutzfeldt–Jakob disease, epidemiology, United Kingdom, population, incidence, variant CJD, carriers, prion infection
49	ADAR1 binds to Dicer to cleave pre-miRNA. ADAR1, Dicer, pre-miRNA, RNA binding, RNA cleavage, microRNA biogenesis, RNA editing, ADAR1-Dicer interaction, miRNA processing ADAR1, Dicer, pre-miRNA, binding, cleavage, RNA editing, microRNA biogenesis, interaction, RNA processing, enzyme complex ADAR1, Dicer, pre-miRNA, binding, cleavage, RNA editing, microRNA biogenesis, RNA-protein interaction, miRNA maturation, double-stranded RNA ADAR1, Dicer, pre-miRNA, RNA cleavage, RNA-binding proteins, microRNA processing, RNA editing, enzyme interaction, miRNA biogenesis, protein-protein interaction ADAR1, Dicer, binding, pre-miRNA, cleavage, RNA editing, microRNA biogenesis, enzyme interaction, post-transcriptional regulation, RNA processing
1385	cSMAC formation enhances weak ligand signalling. cSMAC, central supramolecular activation cluster, weak ligand, signalling, T cell, immunological synapse, signal transduction, ligand affinity, TCR, immune response, synapse formation, molecular clustering, antigen recognition cSMAC, central supramolecular activation cluster, formation, weak ligand, ligand signalling, T cell activation, immunological synapse, signal transduction, TCR signaling, co-stimulation, immune response, molecular clustering cSMAC, central supramolecular activation cluster, weak ligand, signalling, T cell activation, immunological synapse, signal transduction, receptor clustering, antigen presentation, immune response, TCR microclusters, costimulation, synapse assembly, molecular interactions cSMAC, central supramolecular activation cluster, weak ligand, signalling, T cell activation, immune synapse, signal transduction, ligand affinity, immunology, TCR signalling, membrane microdomain, costimulation, receptor clustering, molecular signalling pathways cSMAC, central supramolecular activation cluster, formation, enhancement, weak ligand, signalling, T cell activation, immunological synapse, signal transduction, ligand affinity, receptor clustering, antigen recognition
1021	Rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus. rapid up-regulation, higher basal expression, interferon-induced genes, neuron survival, granule cell neurons, West Nile virus, gene expression, antiviral response, neuronal infection, neuroinflammation, innate immunity, viral pathogenesis, neurodegeneration interferon-induced genes, up-regulation, basal expression, granule cell neurons, West Nile virus, neuronal survival, gene expression, neuroinflammation, antiviral response, infection, neurodegeneration West Nile virus, granule cell neurons, interferon-induced genes, up-regulation, basal expression, neuronal survival, viral infection, gene expression, neuropathogenesis, neuroinflammation rapid up-regulation, basal expression, interferon-induced genes, granule cell neurons, survival, West Nile virus, infection, neuronal death, antiviral response, gene expression, neurovirology, immune response interferon-induced genes, rapid upregulation, basal expression, granule cell neurons, West Nile virus, neuronal survival, gene expression, viral infection, neuroinflammation, antiviral response, neurodegeneration, immune response, apoptosis, neuron death, interferon signaling
1020	Rapid up-regulation and higher basal expression of interferon-induced genes increase survival of granule cell neurons that are infected by West Nile virus. interferon-induced genes, up-regulation, basal expression, granule cell neurons, West Nile virus, neuronal survival, gene expression, antiviral response, neuroprotection, viral infection, immune response, CNS, cytokines, neuroimmunology, cell survival interferon-induced genes, granule cell neurons, West Nile virus, up-regulation, basal expression, neuronal survival, antiviral response, gene expression, neuroprotection, virus infection, immune response rapid up-regulation, basal expression, interferon-induced genes, survival, granule cell neurons, West Nile virus, gene expression, neuronal infection, antiviral response, neuroprotection rapid up-regulation, basal expression, interferon-induced genes, granule cell neurons, survival, West Nile virus, neuronal infection, gene expression, antiviral response, neuroprotection West Nile virus, granule cell neurons, interferon-induced genes, gene expression, up-regulation, basal expression, neuronal survival, viral infection, immune response, neuroprotection
1262	The repair of Cas9-induced double strand breaks in human DNA is error-prone. Cas9, double strand breaks, DNA repair, CRISPR, genome editing, error-prone repair, non-homologous end joining, NHEJ, homology-directed repair, HDR, DNA damage, mutation, human cells, indels, repair pathways Cas9, DNA double strand breaks, repair, error-prone, genome editing, CRISPR, human cells, DNA repair pathways, mutagenesis, non-homologous end joining, NHEJ, homology-directed repair, HDR, DNA damage, genetic engineering Cas9, double strand breaks, DNA repair, human genome, error-prone repair, genome editing, CRISPR, non-homologous end joining, NHEJ, homology-directed repair, HDR, mutagenesis, DSB repair, repair mechanisms, genomic instability Cas9, double strand breaks, DNA repair, error-prone repair, genome editing, human DNA, CRISPR, non-homologous end joining, NHEJ, homology-directed repair, HDR, mutagenesis, DNA damage, gene editing, indels, repair fidelity Cas9, double strand breaks, DNA repair, human genome, error-prone repair, CRISPR, genome editing, non-homologous end joining, NHEJ, DNA damage, mutagenesis, repair outcomes, insertion-deletion mutations, indels, homologous recombination, gene editing errors
1140	Taking 400mg of α-tocopheryl acetate helps to prevent prostate cancer. α-tocopheryl acetate, 400mg, prostate cancer prevention, vitamin E, supplementation, prostate health, cancer risk reduction, dietary supplements, tocopherol, men's health α-tocopheryl acetate, vitamin E, 400mg, prostate cancer prevention, dietary supplements, prostate health, cancer risk reduction, antioxidant, tocopherol, men's health, supplementation, prostate cancer therapy, prostate cancer risk, α-tocopherol, protective effect α-tocopheryl acetate, 400mg, prostate cancer prevention, vitamin E, supplement dosage, prostate health, cancer risk reduction, tocopherol, dietary supplements, antioxidant, men's health 400mg, α-tocopheryl acetate, vitamin E, prostate cancer prevention, prostate cancer, supplementation, cancer risk reduction, tocopherol, male health, antioxidant, dose-response, clinical studies, prevention, dietary supplements α-tocopheryl acetate, 400mg, vitamin E, prostate cancer prevention, supplementation, prostate health, cancer risk reduction, tocopherol, antioxidant, prostate cancer, vitamin E supplementation
1382	aPKCz causes tumour enhancement by affecting glutamine metabolism. aPKCz, tumour enhancement, glutamine metabolism, cancer, tumor growth, metabolic reprogramming, protein kinase C zeta, oncogenesis, metabolic pathways, glutaminolysis, tumor microenvironment, cell proliferation, tumour metabolism, cancer progression, PKCζ, metabolic regulation aPKCz, tumor enhancement, glutamine metabolism, cancer, protein kinase C zeta, metabolic reprogramming, tumor growth, oncogenesis, cellular metabolism, glutaminolysis, signaling pathways, cancer metabolism, tumor progression aPKCz, tumour enhancement, glutamine metabolism, cancer, protein kinase C zeta, metabolic regulation, tumor growth, oncogenesis, amino acid metabolism, cancer metabolism aPKCz, tumour enhancement, glutamine metabolism, cancer, tumor growth, protein kinase C zeta, metabolic regulation, oncogenesis, glutaminolysis, cancer metabolism, signaling pathways, cellular metabolism, tumor progression aPKCz, tumour enhancement, glutamine metabolism, cancer, metabolic reprogramming, protein kinase, tumor growth, glutamine pathway, oncology, cell metabolism, aPKC isoforms, tumorigenesis
274	Combination nicotine replacement therapies with varenicline or bupropion lead to significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy. combination nicotine replacement therapy, NRT, varenicline, bupropion, long-term abstinence, 52 weeks, smoking cessation, monotherapy comparison, tobacco dependence, treatment efficacy, smoking relapse prevention combination therapy, nicotine replacement therapy, NRT, varenicline, bupropion, long-term abstinence, 52-week outcomes, smoking cessation, monotherapy comparison, quit rates, pharmacotherapy, smoking relapse prevention combination nicotine replacement therapy, varenicline, bupropion, smoking cessation, long-term abstinence, 52 weeks, monotherapy, effectiveness, NRT, pharmacotherapy, comparative efficacy, tobacco dependence, randomized trials combination therapy, nicotine replacement, NRT, varenicline, bupropion, long-term abstinence, 52 weeks, smoking cessation, monotherapy comparison, quit rates, dual therapy, randomized controlled trials, effectiveness, pharmacotherapy, tobacco dependence combination nicotine replacement therapy, varenicline, bupropion, long-term abstinence, 52 weeks, smoking cessation, nicotine replacement, monotherapy, higher quit rates, comparative effectiveness
1019	Rapid phosphotransfer rates govern fidelity in two component systems phosphotransfer rates, two component systems, signal transduction, fidelity, protein phosphorylation, histidine kinase, response regulator, kinetic regulation, bacterial signaling, molecular mechanisms phosphotransfer rates, two component systems, signal transduction, fidelity, histidine kinase, response regulator, phosphorylation, kinetic proofreading, bacterial signaling, protein interactions, enzymatic kinetics, cellular signaling fidelity phosphotransfer rates, two component systems, signal transduction, fidelity, bacterial signaling, response regulators, sensor kinases, phosphorylation, specificity, molecular mechanisms, kinetics, regulatory pathways phosphotransfer, two component systems, fidelity, signal transduction, histidine kinase, response regulator, protein phosphorylation, regulatory networks, bacterial signaling, reaction kinetics, enzymatic rates, molecular mechanisms, biochemical pathways, specificity, cellular regulation phosphotransfer rates, two component systems, signal transduction, kinase activity, response regulator, phosphorylation, fidelity, molecular signaling, bacterial signaling, protein interaction, enzymatic kinetics, system specificity, phosphorelay, regulatory networks, biochemical pathways
275	Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is effective at treating KRAS mutant tumors. phosphatidylinositide 3-kinase, PI3K inhibitors, MEK 1/2 inhibitors, combination therapy, KRAS mutant tumors, targeted therapy, cancer treatment, signal transduction, oncogenic KRAS, synergistic inhibition, tumor growth suppression, molecular oncology phosphatidylinositide 3-kinase inhibitors, MEK 1/2 inhibitors, KRAS mutant tumors, combination therapy, cancer treatment, PI3K inhibitors, MEK inhibitors, targeted therapy, KRAS mutations, tumor suppression phosphatidylinositide 3-kinase inhibitors, PI3K inhibitors, MEK 1/2 inhibitors, combination therapy, KRAS mutant tumors, targeted therapy, cancer treatment, signal transduction inhibitors, oncogenic KRAS, dual inhibition, tumor growth suppression, molecular oncology, drug synergy phosphatidylinositide 3-kinase inhibitor, PI3K inhibitor, MEK 1/2 inhibitor, MEK inhibitor, combination therapy, KRAS mutant tumors, targeted therapy, cancer treatment, signal transduction, oncogene, drug synergy, tumor suppression, Ras pathway, MAPK pathway, PI3K pathway phosphatidylinositide 3-kinase inhibitors, PI3K inhibitors, MEK 1/2 inhibitors, combined therapy, KRAS mutant tumors, targeted therapy, cancer treatment, signal transduction, drug synergy, oncogenic KRAS, tumor suppression, molecular oncology, combination therapy, cellular pathways, pharmacological inhibition
1259	The relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome is dependent on the patient's genetic make-up. breast cancer, tamoxifen metabolism, treatment outcome, pharmacogenomics, genetic polymorphism, CYP2D6, drug response, personalized medicine, genotype, endocrine therapy, patient genetics, pharmacokinetics, therapeutic efficacy, breast cancer treatment, tamoxifen efficacy breast cancer, tamoxifen metabolism, treatment outcome, pharmacogenomics, genetic polymorphism, CYP2D6, patient genetics, personalized medicine, pharmacogenetics, drug response, estrogen receptor, metabolizer status, cancer therapy, gene-drug interaction, therapeutic efficacy breast cancer, tamoxifen metabolism, treatment outcome, pharmacogenetics, genetic polymorphism, CYP2D6, patient genetics, drug response, personalized medicine, endocrine therapy, gene-drug interaction, metabolizer status breast cancer, tamoxifen metabolism, treatment outcome, pharmacogenomics, genetic variation, CYP2D6, personalized medicine, drug response, genetic polymorphism, endocrine therapy, patient genetics, metabolizer status, precision oncology breast cancer, tamoxifen metabolism, treatment outcome, pharmacogenetics, CYP2D6, genetic polymorphism, personalized medicine, drug response, metabolizer status, genetic variation, endocrine therapy, cancer prognosis, pharmacokinetics
1137	TNFAIP3 is a tumor suppressor in glioblastoma. TNFAIP3, tumor suppressor, glioblastoma, A20, gene expression, cancer, glioma, apoptosis, NF-κB, cell proliferation, tumorigenesis, brain tumor, molecular pathways, therapeutic target TNFAIP3, tumor suppressor, glioblastoma, gene expression, cancer, A20, molecular mechanisms, glioma, tumor progression, cell signaling, apoptosis, inflammation, NF-κB pathway, genetic mutations, brain tumor TNFAIP3, tumor suppressor, glioblastoma, GBM, cancer, gene expression, A20, apoptosis, NF-κB pathway, tumorigenesis, brain tumor, molecular mechanisms, oncology, cell proliferation, genetic regulation TNFAIP3, tumor suppressor, glioblastoma, tumorigenesis, cancer, gene expression, apoptosis, NF-kB pathway, brain tumor, molecular mechanism, oncogenesis, A20 protein, glioma, cell proliferation, signaling pathway, tumor progression TNFAIP3, tumor suppressor, glioblastoma, gene regulation, cancer, apoptosis, NF-κB pathway, A20 protein, tumorigenesis, molecular mechanism, brain tumor, oncogenesis, therapeutic target, gene expression, cell proliferation
1379	Women with a higher birth weight are more likely to develop breast cancer later in life. women, high birth weight, breast cancer, risk factors, adulthood, epidemiology, later life, perinatal factors, developmental origins, cancer incidence, female, birth weight association women, higher birth weight, breast cancer, later in life, risk factors, adult disease, early life exposures, birth weight association, female health, cancer epidemiology women, high birth weight, breast cancer, adult risk, later life, female, perinatal factors, birth weight, cancer risk, epidemiology, risk factors, developmental origins, long-term health, women's health women, higher birth weight, breast cancer, later in life, risk factors, perinatal factors, adult cancer risk, prenatal influences, epidemiology, female health, birth weight association, cancer development women, higher birth weight, breast cancer, adult risk, later life, perinatal factors, epidemiology, birth weight association, female health, cancer risk factors
399	Exposure to fine particulate air pollution is relate to anxiety prevalence. fine particulate matter, PM2.5, air pollution, anxiety, anxiety prevalence, exposure, mental health, environmental health, particulate exposure, pollution and anxiety, air quality, psychiatric disorders, health effects, atmospheric pollution fine particulate matter, air pollution, anxiety prevalence, PM2.5, mental health, exposure, atmospheric pollution, anxiety disorders, particulate air pollution, environmental exposure, epidemiology, health effects, urban pollution, pollution and mental health, air quality fine particulate matter, PM2.5, air pollution, anxiety, anxiety prevalence, mental health, exposure, environmental risk factors, particulate air pollution, psychological effects, epidemiology, human health, pollution and anxiety, air quality, anxiety disorders fine particulate matter, air pollution, anxiety, prevalence, PM2.5, mental health, exposure, particulate air pollution, epidemiology, environmental health, anxiety disorders, air quality, health effects, psychological impact, pollution exposure fine particulate matter, PM2.5, air pollution, anxiety, mental health, particulate exposure, anxiety prevalence, air quality, environmental health, psychological effects, epidemiology, public health, pollution and anxiety, neuropsychiatric outcomes
279	Commelina yellow mottle virus' (ComYMV) genome consists of 7489 baise pairs. Commelina yellow mottle virus, ComYMV, genome, 7489 base pairs, viral genome length, plant virus, nucleotide sequence, genome size, Commelina virus, virus genetics Commelina yellow mottle virus, ComYMV, genome, 7489 base pairs, viral genome length, nucleotide sequence, plant virus, genome size, Commelina virus, virus classification, viral genetics Commelina yellow mottle virus, ComYMV, genome, 7489 base pairs, genome length, virus genetics, nucleotide sequence, plant virus, viral genome size, Commelina virus, genomics, base pairs, sequence analysis Commelina yellow mottle virus, ComYMV, genome, 7489 base pairs, sequence, viral genome, molecular characterization, genome length, Commelina virus, base pairs, plant virus, Commelina yellow mottle, virus genome size, virology, genomic sequence Commelina yellow mottle virus, ComYMV, genome, 7489 base pairs, sequence length, viral genome, genomics, plant virus, Commelina, nucleotide sequence
1014	Rapamycin decreases the concentration of triacylglycerols in fruit flies. Rapamycin, triacylglycerols, lipid metabolism, Drosophila, fruit flies, TAG, triglyceride reduction, mTOR inhibitor, fat storage, rapamycin effects, metabolic regulation, insect model, lipid concentration, longevity, drug intervention, experimental study Rapamycin, triacylglycerols, triglycerides, Drosophila, fruit flies, lipid metabolism, fat storage, mTOR inhibitor, longevity, lifespan, metabolic regulation, lipid homeostasis, pharmacological intervention, rapamycin treatment, energy metabolism Rapamycin, triacylglycerols, concentration, decrease, Drosophila, fruit flies, lipid metabolism, mTOR inhibitor, fat storage, triglycerides, pharmacological intervention, metabolic regulation, lifespan, energy homeostasis Rapamycin, triacylglycerols, triglycerides, Drosophila, fruit flies, lipid metabolism, concentration, decrease, fat storage, mTOR inhibitor, lifespan, metabolic regulation, pharmacology, gene expression, aging Rapamycin, triacylglycerols, triglycerides, Drosophila, fruit flies, lipid metabolism, fat storage, mTOR inhibitor, lipid reduction
830	NF2 (Merlin) causes phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila by activating LATS1/2 kinases. NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, LATS1, LATS2, Hippo pathway, kinase activation, YAP regulation, tumor suppressor, signal transduction NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinase activation, Hippo pathway, tumor suppressor, signaling, YAP phosphorylation, merlin function, drosophila genetics NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway, signal transduction, tumor suppressor, YAP regulation, kinase activation, cellular localization NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, LATS1, LATS2, kinases, Hippo pathway, tumor suppressor, YAP localization, signaling, phosphorylation cascade, Drosophila melanogaster, YAP regulation NF2, Merlin, YAP, phosphorylation, cytoplasmic sequestration, Drosophila, LATS1, LATS2, kinases, Hippo pathway, tumor suppressor, signaling, YAP localization, Hippo signaling, YAP phosphorylation, NF2 function, LATS activation
831	NF2 (Merlin) prevents phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila. NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, Hippo pathway, YAP localization, tumor suppressor, neurofibromin 2, cell signaling, Yki, subcellular localization, signal transduction NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, Hippo pathway, tumor suppressor, YAP regulation, Yki, signal transduction, cellular localization NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, Hippo pathway, tumor suppressor, YAP localization, NF2 YAP interaction, signaling pathway, subcellular localization NF2, Merlin, phosphorylation, cytoplasmic sequestration, YAP, Drosophila, Hippo pathway, YAP regulation, neurofibromin 2, protein phosphorylation, molecular mechanisms, signal transduction, subcellular localization NF2, Merlin, phosphorylation, YAP, cytoplasmic sequestration, Drosophila, Hippo pathway, Yki, tumor suppressor, cell signaling, localization, protein interaction, phosphorylation inhibition, neurofibromin 2, YAP regulation, subcellular localization, Drosophila melanogaster
1012	Radioiodine treatment of non-toxic multinodular goitre reduces thyroid volume. radioiodine therapy, non-toxic multinodular goitre, thyroid volume reduction, radioactive iodine, benign thyroid nodules, thyroid shrinkage, goitre management, multinodular goiter treatment, thyroid gland, radionuclide therapy radioiodine therapy, non-toxic multinodular goitre, thyroid volume reduction, RAI treatment, multinodular thyroid, goitre management, thyroid shrinkage, non-toxic goiter, radioiodine ablation, thyroid nodules radioiodine, non-toxic multinodular goitre, thyroid volume reduction, radioiodine therapy, multinodular goiter, thyroid shrinkage, I-131 treatment, non-toxic goitre, thyroid nodule, thyroid treatment radioiodine therapy, non-toxic multinodular goitre, thyroid volume reduction, goiter treatment, thyroid nodule therapy, iodine-131, non-toxic goiter, multinodular goiter, thyroid shrinkage, radioiodine ablation radioiodine therapy, non-toxic multinodular goitre, thyroid volume reduction, thyroid nodule, goitre treatment, iodine-131, thyroid shrinkage, multinodular goiter, non-toxic goitre, radioiodine ablation
832	NFAT4 activation requires IP3R-mediated Ca2+ mobilization. NFAT4, activation, IP3R, IP3 receptor, Ca2+ mobilization, calcium signaling, nuclear factor of activated T-cells, signal transduction, calcium release, intracellular calcium, second messenger, IP3 pathway, gene expression NFAT4, activation, IP3R, IP3 receptor, Ca2+ mobilization, calcium signaling, intracellular calcium, calcium release, NFAT4 pathway, calcium-dependent activation, second messenger, signaling cascade, gene expression, transcription factor, immunophilin, cell signaling NFAT4, activation, IP3R, Ca2+ mobilization, inositol trisphosphate receptor, calcium signaling, nuclear factor of activated T-cells, calcium release, intracellular calcium, calcium-dependent signaling, signal transduction NFAT4, activation, IP3R, inositol 1,4,5-trisphosphate receptor, Ca2+ mobilization, calcium signaling, nuclear factor of activated T cells, calcium release, intracellular signaling, signal transduction NFAT4, activation, IP3R, IP3 receptor, Ca2+ mobilization, calcium signaling, intracellular calcium, signal transduction, nuclear factor of activated T-cells, calcium release, NFAT4 activation mechanism, Ca2+ release, ER calcium, inositol 1,4,5-trisphosphate receptor
834	NOX2-independent pathways can generate peroxynitrite by reacting with nitrogen intermediates. NOX2-independent, peroxynitrite generation, nitrogen intermediates, oxidative pathways, reactive nitrogen species, alternative NOX2 pathways, peroxynitrite synthesis, nitric oxide, superoxide, non-NOX2 sources, redox biology, cellular oxidation, ROS, RNS NOX2-independent, peroxynitrite generation, nitrogen intermediates, reactive nitrogen species, alternative pathways, oxidative stress, cellular signaling, enzymatic pathways, peroxynitrite synthesis, reactive oxygen species NOX2-independent, peroxynitrite generation, nitrogen intermediates, reactive nitrogen species, alternative pathways, oxidative stress, ROS, RNS, enzyme mechanisms, inflammatory response NOX2-independent, peroxynitrite generation, nitrogen intermediates, reactive nitrogen species, oxidative stress, alternative pathways, NOX2, peroxynitrite formation, reactive oxygen species, non-NOX2 enzymatic pathways, nitric oxide, superoxide, nitrosative stress NOX2-independent, peroxynitrite generation, nitrogen intermediates, reactive nitrogen species, alternative pathways, oxidative stress, NOX2 deficiency, peroxynitrite synthesis, nitric oxide, superoxide, redox biology
956	Pleiotropic coupling of GLP-1R to intracellular effectors promotes distinct profiles of cellular signaling. Pleiotropic coupling, GLP-1R, intracellular effectors, cellular signaling, signaling pathways, bias signaling, G protein-coupled receptors, signal transduction, downstream effectors, pharmacological modulation, receptor activation, functional selectivity GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, signal transduction, GPCR, biased agonism, downstream pathways, cAMP, beta-arrestin, G protein, pharmacology, receptor signaling, effector specificity, signaling pathways GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, signal transduction, G protein-coupled receptor, biased agonism, downstream pathways, signaling profiles, receptor activation, pharmacology, functional selectivity, cAMP, beta-arrestin, second messengers GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, signal transduction, receptor signaling, GPCR, biased agonism, pathway specificity, second messengers, pharmacology, downstream effectors, signaling pathways, distinct profiles GLP-1R, pleiotropic coupling, intracellular effectors, cellular signaling, signal transduction, GPCR, biased agonism, downstream pathways, receptor signaling, pharmacology, β-arrestin, cAMP, protein kinase A, ERK1/2, G protein signaling, cellular response, therapeutic targets
50	AIRE is expressed in some skin tumors. AIRE, expression, skin tumors, tumor markers, immunohistochemistry, cutaneous neoplasms, autoimmune regulator, skin cancer, gene expression, dermatopathology, neoplastic lesions, AIRE protein, skin pathology AIRE, skin tumors, expression, autoimmune regulator, neoplasms, immunohistochemistry, cutaneous tumors, tumor markers, skin cancer, gene expression AIRE, expression, skin tumors, cutaneous neoplasms, autoimmune regulator, tumor markers, immunohistochemistry, skin cancer, neoplasm expression, dermatopathology, AIRE protein, oncogenesis AIRE, expression, skin tumors, tumor markers, skin neoplasms, autoimmunity, immunohistochemistry, cutaneous tumors, transcription factor, skin cancer, AIRE protein, tumor expression, dermatopathology AIRE, expression, skin tumors, tumor markers, autoimmune regulator, skin neoplasms, immunohistochemistry, cutaneous tumors, AIRE protein, dermal tumors, gene expression, cancer biomarkers
715	Low expression of miR7a does represses target genes and exerts a biological function in ovaries. miR7a, low expression, gene repression, target genes, biological function, ovaries, microRNA, ovarian regulation, gene expression, reproductive biology miR7a, low expression, gene repression, target genes, biological function, ovaries, microRNA, gene regulation, ovarian function, molecular mechanisms miR7a, low expression, gene repression, target genes, biological function, ovaries, microRNA, gene regulation, ovarian function, miRNA, gene expression miR7a, low expression, gene repression, target genes, biological function, ovaries, microRNA, gene regulation, ovarian biology, gene expression miR7a, low expression, gene repression, target genes, biological function, ovaries, microRNA, gene regulation, ovarian function, miR-7a, expression levels, ovarian biology
957	Podocytes are motile and migrate in the presence of injury. podocyte motility, podocyte migration, podocyte injury, glomerular injury, podocyte movement, kidney disease, renal pathology, cytoskeleton rearrangement, cell migration, podocyte damage podocytes, motility, migration, injury, cell movement, glomerular injury, renal pathology, cytoskeleton, kidney disease, cellular response, nephrology, proteinuria, actin dynamics, podocyte damage, wound healing podocytes, motility, migration, cell movement, injury response, glomerular injury, kidney, cytoskeleton, podocyte dynamics, renal pathology, podocyte behavior, cell migration, nephrology podocytes, motility, migration, injury response, cell movement, glomerular injury, cytoskeleton, kidney disease, cellular migration, renal pathology, podocyte dynamics, damage response, actin remodeling, proteinuria, glomerulus podocytes, motility, migration, injury, glomerular disease, cell movement, renal injury, podocyte dynamics, kidney injury, cytoskeleton, podocyte response, pathology
51	ALDH1 expression is associated with better breast cancer outcomes. ALDH1, breast cancer, expression, prognosis, outcomes, survival, biomarker, positive association, clinical studies, disease progression, cancer marker, patient prognosis ALDH1, expression, breast cancer, prognosis, outcomes, survival, biomarker, predictor, positive association, clinical significance ALDH1, breast cancer, expression, prognosis, outcomes, survival, biomarkers, predictive markers, tumor progression, breast neoplasms, clinical outcomes, cancer prognosis, immunohistochemistry, cancer biomarker, favorable prognosis ALDH1, expression, breast cancer, outcomes, prognosis, survival, biomarker, positive association, clinical significance, patient outcomes, tumor marker ALDH1, breast cancer, expression, prognosis, outcomes, survival, biomarker, positive association, clinical significance, tumor marker, cancer prognosis, patient outcomes, breast carcinoma
716	Low expression of miR7a exerts a biological function in testis. miR7a, low expression, biological function, testis, microRNA, gene regulation, testicular function, male fertility, miRNA, reproductive biology miR7a, low expression, testis, biological function, gene regulation, spermatogenesis, microRNA, testicular function, reproductive biology, miR-7a, male fertility, molecular mechanism, gene expression, testicular development, microRNA-7a miR7a, low expression, biological function, testis, microRNA, male reproduction, gene regulation, spermatogenesis, testicular function, miRNA, reproductive biology miR7a, low expression, testis, biological function, microRNA, gene regulation, male reproduction, spermatogenesis, testicular tissue, molecular mechanism, expression levels, reproductive biology miR7a, low expression, biological function, testis, microRNA, gene regulation, reproductive biology, spermatogenesis, testicular function, miRNA, molecular mechanism
837	NR5A2 is important in development of endometrial tissues. NR5A2, endometrial development, endometrial tissue, gene regulation, transcription factor, reproductive biology, uterine development, endometrium, gene expression, molecular pathways NR5A2, endometrial development, endometrial tissue, transcription factors, uterine biology, gene expression, reproductive system, endometrium, molecular mechanisms, tissue differentiation, fertility, hormonal regulation, developmental biology NR5A2, endometrial development, endometrial tissue, endometrial biology, nuclear receptor, gene regulation, uterine development, reproductive biology, transcription factors, steroidogenic factor 1, SF-1, endometrium, developmental biology, tissue differentiation, gynecological research NR5A2, endometrial development, endometrial tissue, gene regulation, transcription factors, reproductive biology, uterine development, endometrium, molecular pathways, fertility, embryogenesis, hormone regulation NR5A2, endometrial development, endometrium, transcription factors, uterine tissue, gene regulation, reproductive biology, embryonic development, tissue differentiation, female reproductive system, nuclear receptors, gene expression, fertility, uterus, endometrial function
53	ALDH1 expression is associated with poorer prognosis in breast cancer. ALDH1, expression, poorer prognosis, breast cancer, biomarker, survival, outcome, cancer progression, prognostic factor, tumor aggressiveness, patient prognosis, clinicopathological features ALDH1, ALDH1 expression, breast cancer, prognosis, poor prognosis, biomarker, survival, cancer progression, clinical outcome, breast tumor, patient outcome, prognostic marker ALDH1, expression, poorer prognosis, breast cancer, prognostic marker, survival, clinical outcome, tumor aggressiveness, biomarker, cancer progression ALDH1, expression, poor prognosis, breast cancer, biomarker, survival, outcome, progression, tumor, malignant, clinical significance, predictive, prognostic marker ALDH1, expression, breast cancer, prognosis, poor outcome, biomarker, survival, cancer progression, tumor marker, cancer prognosis
718	Low nucleosome occupancy correlates with low methylation levels across species. nucleosome occupancy, DNA methylation, methylation levels, chromatin structure, cross-species comparison, epigenetics, genome organization, gene regulation, evolutionary conservation, species differences, hypomethylation, nucleosome positioning nucleosome occupancy, DNA methylation, low occupancy, low methylation, chromatin structure, epigenetics, species comparison, cross-species analysis, genomic methylation, chromatin accessibility, methylation patterns, comparative genomics nucleosome occupancy, DNA methylation, cross-species comparison, chromatin structure, epigenetics, genome organization, methylation correlation, comparative genomics, histone modification, species variation nucleosome occupancy, DNA methylation, methylation levels, chromatin structure, epigenetics, cross-species comparison, comparative genomics, species variation, gene regulation, nucleosome positioning, hypomethylation, transcription regulation, evolutionary conservation, DNA accessibility, epigenomic profiling nucleosome occupancy, DNA methylation, methylation levels, epigenetics, cross-species, chromatin structure, comparative genomics, histone modification, species differences, gene regulation
839	Nanoparticles can be targeted against specific cell types by incorporating aptamers into lipid nanoparticles. nanoparticles, targeted delivery, specific cell types, aptamers, lipid nanoparticles, targeted therapy, cell targeting, nanomedicine, aptamer-functionalized nanoparticles, drug delivery, precision medicine, targeted nanocarriers nanoparticles, targeted delivery, cell-specific targeting, aptamers, lipid nanoparticles, drug delivery, molecular recognition, functionalized nanoparticles, targeted therapy, biomolecular targeting, nanomedicine, precision medicine, ligand-conjugated nanoparticles nanoparticles, targeted delivery, cell-specific targeting, aptamers, lipid nanoparticles, drug delivery, nanomedicine, targeted therapy, ligand-mediated targeting, nucleic acid aptamers, cell targeting, nanoparticle functionalization, precision medicine nanoparticles, targeted delivery, cell specificity, aptamers, lipid nanoparticles, drug delivery, targeted therapy, cell targeting, nanomedicine, surface modification, aptamer-functionalized nanoparticles, ligand-mediated targeting, selective delivery, biomedical nanotechnology, therapeutic nanoparticles nanoparticles, lipid nanoparticles, aptamers, targeted delivery, cell-specific targeting, drug delivery, molecular recognition, surface modification, functionalization, biomedical applications, therapeutic delivery, nanomedicine, targeted therapy, ligand-mediated targeting, biomolecular targeting
54	AMP-activated protein kinase (AMPK) activation increases inflammation-related fibrosis in the lungs. AMPK activation, lung fibrosis, inflammation, pulmonary fibrosis, AMP-activated protein kinase, inflammatory response, fibrogenesis, lung injury, fibrosis mechanisms, AMPK pathway, cytokines, pro-fibrotic signaling, pulmonary inflammation, tissue remodeling AMPK activation, lung fibrosis, inflammation, pulmonary fibrosis, AMP-activated protein kinase, fibrosis mechanisms, inflammatory pathways, lung inflammation, fibrogenesis, AMPK signaling, respiratory inflammation, fibrosis progression AMPK activation, lung fibrosis, inflammation, pulmonary fibrosis, AMPK, inflammatory response, lung inflammation, fibrosis mechanisms, AMP-activated protein kinase, pro-fibrotic signaling, respiratory fibrosis, cytokines, fibrogenesis, lung disease, immune response, fibrosis pathway AMPK activation, lung fibrosis, inflammation, pulmonary fibrosis, AMP-activated protein kinase, inflammatory response, fibrogenesis, lung tissue, profibrotic signaling, cytokines, fibrotic markers, respiratory inflammation AMP-activated protein kinase, AMPK activation, lung fibrosis, inflammation, pulmonary fibrosis, inflammatory response, lung tissue, fibrosis pathways, AMPK signaling, pro-fibrotic, cytokines, lung inflammation
56	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation causing GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau pathology, neuronal loss, induced pluripotent stem cells, APOE4 expression, tau hyperphosphorylation, GABAergic neurons, neurotoxicity APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, Alzheimer's disease, neurodegeneration, amyloid beta, tau pathology, induced pluripotent stem cells, neuronal toxicity, genetic risk, neuronal differentiation, neurobiology, synaptic dysfunction APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau pathology, neuronal loss, genetic risk factors, neurotoxicity, synaptic dysfunction, neural differentiation APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau pathology, neuronal loss, stem cell models, molecular mechanisms, synaptic dysfunction, excitotoxicity APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer’s disease, amyloid beta, tau pathology, neuronal loss, induced pluripotent stem cells, synaptic dysfunction, neuronal vulnerability, pathological mechanisms, neurotoxicity
57	APOE4 expression in iPSC-derived neurons increases AlphaBeta production and tau phosphorylation, delaying GABA neuron degeneration. APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, tau pathology, neuronal differentiation, APOE4 expression, stem cell models APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, Alzheimer's disease, neurodegeneration, amyloid beta, tau pathology, neuronal models, synaptic function, neurobiology, stem cell models, neurotoxicity APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer's disease, amyloid beta, induced pluripotent stem cells, neuronal models, tau pathology, APOE genotype, neurobiology APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, neurodegeneration, Alzheimer’s disease, amyloid beta, tau pathology, induced pluripotent stem cells, neuronal models, APOE4 effects, neurobiology, synaptic dysfunction, neurodegenerative mechanisms APOE4, iPSC-derived neurons, AlphaBeta production, tau phosphorylation, GABA neuron degeneration, Alzheimer's disease, neurodegeneration, amyloid beta, tau protein, neuronal pathology, induced pluripotent stem cells, APOE4 expression
1274	The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) carries toxic effector proteins. type VI secretion system, T6SS, inner tube, antibacterial effector, toxic effector proteins, Escherichia coli, E. coli, tip structure, protein delivery, bacterial competition, secretion apparatus, antibacterial toxins Type VI secretion system, T6SS, Escherichia coli, E. coli, inner tube tip, antibacterial effector, toxic effectors, effector proteins, bacterial secretion system, bacterial toxins, protein delivery, molecular mechanism, bacterial competition, toxin-antitoxin, secretion apparatus, interbacterial interaction, effector delivery, bacterial warfare, microbiology Type VI secretion system, T6SS, antibacterial effector, inner tube tip, Escherichia coli, E. coli, toxic effector proteins, protein delivery, antibacterial mechanism, bacterial toxins, effector domain, tube-associated toxins, bacterial competition, secretion apparatus, molecular mechanism Type VI secretion system, T6SS, antibacterial effector, Escherichia coli, E. coli, inner tube tip, toxic effector proteins, secretion system structure, bacterial competition, toxin delivery, effector protein carriage, T6SS mechanism, antibacterial activity, protein translocation, bacterial virulence type VI secretion system, T6SS, Escherichia coli, E. coli, antibacterial effector, inner tube tip, toxic effector proteins, toxin delivery, bacterial competition, effector mechanism, bacterial warfare, protein secretion, bacterial pathogenesis, effector targeting
1395	p16INK4A accumulation is  linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). p16INK4A, accumulation, abnormal wound response, microinvasion, microinvasive, advanced, Oral Potentially Malignant Lesions, OPML, oral lesions, malignant transformation, biomarkers, cancer progression, oral pathology, epithelial dysplasia, senescence, tumor suppressor p16INK4A, accumulation, abnormal wound response, microinvasion, advanced, Oral Potentially Malignant Lesions, OPMLs, biomarker, carcinogenesis, epithelial dysplasia, oral cancer, tumor progression, cellular senescence, molecular pathology, oral precancerous lesions p16INK4A, accumulation, abnormal wound response, microinvasion, advanced Oral Potentially Malignant Lesions, OPMLs, biomarkers, oral cancer, carcinogenesis, epithelial dysplasia, malignant transformation, tissue invasion, senescence, pathogenesis p16INK4A, accumulation, abnormal wound response, microinvasive, advanced, Oral Potentially Malignant Lesions, OPMLs, biomarker, oral cancer, carcinogenesis, epithelial dysplasia, invasion, senescence, cell cycle arrest, oral precancer, pathogenesis p16INK4A, accumulation, abnormal wound response, microinvasion, microinvasive step, Oral Potentially Malignant Lesions, OPMLs, advanced OPMLs, oral cancer, precancerous lesions, wound healing, biomarker, pathogenesis, malignancy progression, epithelial dysplasia
1273	The sliding activity of kinesin-8 protein Kip3 promotes bipolar spindle assembly. kinesin-8, Kip3, sliding activity, bipolar spindle assembly, microtubule dynamics, mitosis, spindle formation, motor protein, cell division, microtubule organization kinesin-8, Kip3, sliding activity, bipolar spindle assembly, spindle dynamics, mitosis, microtubule, motor protein, cell division, spindle organization kinesin-8, Kip3, sliding activity, bipolar spindle assembly, mitosis, microtubules, spindle dynamics, motor proteins, yeast, spindle organization kinesin-8, Kip3, sliding activity, bipolar spindle assembly, spindle dynamics, mitosis, microtubule, motor protein, cell division, chromosome segregation kinesin-8, Kip3, sliding activity, bipolar spindle assembly, microtubule dynamics, mitosis, spindle elongation, motor protein, chromosome segregation, cell division
1272	The single flash-evoked ERG b-wave is generated by activity of ON-bipolar cells. single flash, flash-evoked, ERG, electroretinography, b-wave, ON-bipolar cells, retinal activity, retinal electrophysiology, inner retina, visual signal, retina, photoreceptors, retinal bipolar cells flash-evoked ERG, b-wave, ON-bipolar cells, retinal electrophysiology, electroretinogram, retinal response, retinal bipolar cells, visual pathway, retinal signal generation, ERG components flash-evoked ERG, b-wave, ON-bipolar cells, electroretinogram, retinal signaling, retina, electrophysiology, visual neuroscience, signal generation, phototransduction flash-evoked ERG, b-wave, ON-bipolar cells, electroretinogram, retinal electrophysiology, signal generation, retinal response, visual pathway, ON pathway, bipolar cell activity flash-evoked ERG, b-wave, ON-bipolar cells, electroretinography, retinal response, electrophysiology, retina, visual pathways, signal generation, ERG components
1150	Tetraspanin-3 is a causative factor in the development of acute myelogenous leukemia Tetraspanin-3, acute myelogenous leukemia, AML, causative factor, leukemogenesis, hematologic malignancy, tetraspanin family, oncogenesis, gene expression, biomarker, therapeutic target, pathogenesis, molecular mechanisms, hematopoietic cells, cancer progression Tetraspanin-3, acute myelogenous leukemia, AML, causative factor, leukemia development, tetraspanins, hematologic malignancies, cancer progression, gene expression, leukemogenesis, TSPAN3, oncogenesis, molecular mechanisms, pathogenesis, biomarkers Tetraspanin-3, AML, acute myelogenous leukemia, leukemogenesis, causative factor, tumorigenesis, hematologic malignancy, biomarker, molecular mechanism, oncogenesis, prognosis, genetic marker, TSPAN3, therapeutic target, pathogenesis Tetraspanin-3, AML, acute myelogenous leukemia, pathogenesis, causative factor, leukemogenesis, biomarkers, hematologic malignancy, gene expression, cancer progression, molecular mechanisms, cell signaling, oncogenesis, disease development, target therapy Tetraspanin-3, AML, acute myelogenous leukemia, leukemogenesis, causative factor, hematologic malignancy, pathogenesis, biomarker, molecular mechanism, gene expression, cancer progression, oncogenesis, hematopoiesis, tetraspanin family
1271	The severity of cardiac involvement in amyloidosis can be described by the degree of transmurality of late gadolinium enhancement in MRI. cardiac involvement, amyloidosis, severity, transmurality, late gadolinium enhancement, MRI, cardiac MRI, myocardial infiltration, gadolinium uptake, myocardial amyloid, imaging biomarkers, cardiac amyloidosis, LGE, cardiac MRI quantification amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI, cardiac MRI, myocardial infiltration, gadolinium, myocardial fibrosis, LGE, imaging biomarkers, cardiac amyloidosis, disease staging, myocardial involvement amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, MRI, cardiac MRI, myocardial infiltration, cardiac amyloidosis, gadolinium enhancement, imaging biomarkers, myocardial tissue characterization, LGE, cardiac fibrosis, amyloid deposition amyloidosis, cardiac involvement, severity, transmurality, late gadolinium enhancement, LGE, MRI, cardiac MRI, myocardial involvement, gadolinium-enhanced MRI, cardiac amyloidosis, myocardial fibrosis, enhancement patterns, diagnostic imaging, cardiac assessment, cardiac MRI findings cardiac involvement, amyloidosis, severity, transmurality, late gadolinium enhancement, LGE, MRI, cardiac MRI, myocardial involvement, gadolinium enhancement, myocardial amyloidosis, cardiac imaging, cardiac gadolinium, transmural enhancement, amyloid cardiomyopathy
1270	The risk of male prisoners harming themselves is ten times that of female prisoners. male prisoners, female prisoners, self-harm, risk comparison, gender differences, incarceration, prison population, suicide risk, prisoner mental health, self-injury, prison statistics, inmate behavior, gender disparity, correctional facilities, mental health in prisons male prisoners, female prisoners, self-harm, risk comparison, self-injury, prison population, gender differences, incarceration, suicide risk, offender health, prison mental health, inmate safety, gender disparity, prison statistics, self-harm prevalence male prisoners, female prisoners, self-harm, risk comparison, gender differences, prison population, suicide risk, inmate mental health, prison self-injury, gender disparity, incarceration, prison statistics, prisoner wellbeing male prisoners, female prisoners, self-harm, risk, prison, gender differences, suicide, incidence rate, correctional facilities, inmate mental health, comparative study male prisoners, female prisoners, self-harm, risk comparison, gender differences, prison population, suicide risk, inmate mental health, incarceration, prison self-injury, prevalence, prison statistics, gender disparity, correctional facilities
163	Bariatric surgery has a positive impact on mental health. bariatric surgery, mental health, psychological outcomes, weight loss surgery, depression, anxiety, mood improvement, quality of life, post-surgical mental health, psychosocial benefits bariatric surgery, mental health, psychological outcomes, weight loss surgery, depression, anxiety, quality of life, post-surgery mental health, emotional well-being, psychiatric outcomes, obesity treatment, psychological benefits, mood improvement bariatric surgery, mental health, psychological impact, weight loss surgery, depression, anxiety, quality of life, emotional wellbeing, psychiatric outcomes, mood improvement, post-surgery mental health, psychosocial effects, obesity treatment, bariatric outcomes, mental health benefits bariatric surgery, mental health, psychological outcomes, weight loss surgery, depression, anxiety, mood disorders, emotional wellbeing, psychiatric benefits, bariatric outcomes, quality of life, obesity surgery, mental health improvement bariatric surgery, mental health, psychological outcomes, weight loss surgery, depression, anxiety, mood improvement, emotional well-being, psychosocial effects, quality of life, psychiatric disorders, postoperative mental health, obesity treatment, psychological benefits, bariatric procedure
1029	Reduced responsiveness to interleukin-2 in regulatory T cells is associated with greater resistance to autoimmune diseases such as Type 1 Diabetes. regulatory T cells, IL-2, interleukin-2 responsiveness, autoimmune disease resistance, type 1 diabetes, Treg function, immune regulation, autoimmunity, cytokine signaling, T cell modulation interleukin-2, reduced responsiveness, regulatory T cells, autoimmune disease resistance, type 1 diabetes, immune regulation, Treg function, IL-2 signaling, autoimmunity, T cell tolerance, beta cell protection reduced interleukin-2 responsiveness, regulatory T cells, autoimmune disease resistance, Type 1 Diabetes, Treg IL-2 signaling, autoimmunity, immune regulation, T cell tolerance, IL-2 receptor, immune suppression regulatory T cells, interleukin-2, IL-2 responsiveness, autoimmune disease resistance, Type 1 Diabetes, Treg cells, immune tolerance, autoimmunity, cytokine signaling, immune regulation, diabetes prevention, T cell function, immunology regulatory T cells, interleukin-2, IL-2 responsiveness, autoimmune disease resistance, Type 1 Diabetes, Treg function, immune tolerance, autoimmunity, T cell signaling, immunoregulation
960	Polymeal nutrition reduces cardiovascular mortality. Polymeal, nutrition, cardiovascular mortality, cardiovascular disease, heart health, mortality reduction, dietary intervention, cardiovascular prevention, nutrition therapy, Polymeal diet, cardiovascular risk, diet and heart disease, preventive nutrition Polymeal, nutrition, cardiovascular mortality, cardiovascular disease, heart health, dietary interventions, mortality reduction, polymeal diet, cardiovascular risk, nutritional therapy, heart disease prevention, diet and mortality, polymeal benefits Polymeal, nutrition, cardiovascular mortality, cardiovascular disease, heart health, dietary intervention, nutrition therapy, mortality reduction, polymeal diet, cardiovascular prevention, cardiovascular risk, heart disease prevention, cardiovascular outcomes, nutritional intervention Polymeal, nutrition, cardiovascular mortality, heart disease, cardiovascular health, nutrient intervention, mortality reduction, diet intervention, cardiovascular prevention, dietary patterns, heart health, nutrition therapy, polymeal diet, mortality risk, cardioprotective diet Polymeal, nutrition, cardiovascular mortality, cardiovascular disease, heart health, mortality reduction, dietary intervention, polymeal diet, nutrition therapy, cardiovascular prevention, nutrition intervention, cardiovascular risk, heart disease prevention
1389	mTORC2 regulates intracellular cysteine levels through xCT inhibition. mTORC2, intracellular cysteine, xCT inhibition, cystine/glutamate antiporter, cysteine regulation, sulfur metabolism, amino acid transport, oxidative stress, cellular metabolism, SLC7A11, redox balance, glutathione synthesis, signal transduction, metabolic pathway, nutrient sensing mTORC2, intracellular cysteine, xCT inhibition, cystine/glutamate antiporter, cysteine metabolism, sulfur amino acids, cellular redox, mTOR pathway, SLC7A11, oxidative stress, cystine transport, redox homeostasis, glutathione, amino acid transport, cysteine biosynthesis mTORC2, intracellular cysteine, xCT inhibition, cysteine regulation, mTORC2 signaling, amino acid transport, SLC7A11, redox homeostasis, cystine/glutamate antiporter, cellular metabolism mTORC2, intracellular cysteine, xCT inhibition, cystine/glutamate antiporter, SLC7A11, redox homeostasis, amino acid transport, cysteine metabolism, cellular signaling, mTOR signaling, oxidative stress, cystine uptake, sulfur amino acids, glutathione synthesis, metabolic regulation mTORC2, intracellular cysteine, xCT inhibition, cystine/glutamate antiporter, amino acid metabolism, sulfur metabolism, SLC7A11, redox regulation, cell signaling, cysteine transporter, metabolic regulation, oxidative stress
1146	Teaching hospitals do not provide better care than non-teaching hospitals. teaching hospitals, non-teaching hospitals, comparison, quality of care, patient outcomes, healthcare quality, medical education, hospital performance, clinical outcomes, evidence, healthcare delivery, hospital type, patient mortality, care effectiveness, teaching status teaching hospitals, non-teaching hospitals, quality of care, healthcare outcomes, hospital comparison, patient outcomes, clinical performance, medical education, hospital effectiveness, care quality, academic hospitals, community hospitals, treatment results, healthcare quality analysis teaching hospitals, non-teaching hospitals, quality of care, healthcare outcomes, hospital comparison, clinical outcomes, patient care, academic hospitals, community hospitals, hospital performance, medical education, patient outcomes, healthcare quality, hospital type, treatment effectiveness teaching hospitals, non-teaching hospitals, quality of care, patient outcomes, hospital comparison, healthcare quality, academic hospitals, community hospitals, care effectiveness, medical education, hospital performance, clinical outcomes, care quality comparison, healthcare research teaching hospitals, non-teaching hospitals, quality of care, healthcare outcomes, hospital comparison, patient outcomes, medical education, hospital performance, clinical outcomes, care quality, academic hospitals, patient safety, hospital efficacy, healthcare quality, treatment effectiveness
1024	Recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes. recurrent mutations, CTCF anchor sites, oncogenes, mutation hotspots, regulatory regions, chromatin architecture, cancer genomics, transcriptional regulation, cis-regulatory elements, genome instability, mutation frequency, enhancer regions recurrent mutations, CTCF anchor sites, oncogenes, mutation frequency, cancer genomics, regulatory elements, chromatin architecture, genome instability, mutation hotspots, gene regulation, tumorigenesis, DNA binding sites, cancer drivers recurrent mutations, CTCF anchor sites, oncogenes, mutation frequency, chromatin architecture, cis-regulatory elements, cancer genomics, gene regulation, mutation hotspots, DNA binding sites recurrent mutations, CTCF anchor sites, oncogenes, mutation frequency, chromatin organization, cancer genomics, genomic instability, regulatory elements, transcriptional regulation, chromatin looping, structural variation, DNA binding sites, gene regulation, tumorigenesis, genetic alterations recurrent mutations, CTCF anchor sites, oncogenes, mutation frequency, cancer genomics, genomic regulatory elements, chromatin organization, gene regulation, tumorigenesis, cancer mutations, chromatin architecture, enhancer-promoter interactions, regulatory mutations, 3D genome, mutation hotspots
1266	The risk of breast cancer among parous women increases with placental weight of pregnancies, and this association is strongest for premenopausal breast cancer. breast cancer, parous women, placental weight, pregnancy, premenopausal, cancer risk, maternal factors, epidemiology, reproductive history, pregnancy outcomes, hormone exposure, risk factors breast cancer, parous women, placental weight, pregnancy, premenopausal, cancer risk, pregnancy outcomes, maternal health, placental factors, epidemiology, reproductive factors, women's health, breast cancer risk factors breast cancer, parous women, placental weight, pregnancy, premenopausal, cancer risk, epidemiology, reproductive factors, maternal health, pregnancy outcomes, hormonal factors breast cancer, parous women, placental weight, pregnancy, risk factors, premenopausal, association, maternal health, epidemiology, pregnancy outcomes, hormonal factors, reproductive history, cancer risk, obstetric factors, women's health breast cancer, parous women, placental weight, pregnancy, cancer risk, premenopausal, premenopausal breast cancer, maternal risk factors, reproductive factors, pregnancy outcomes, increased risk, epidemiology
721	Lupus-prone mice infected with curliproducing bacteria have higher autoantibody titers compared to controls. Lupus-prone mice, infection, curli-producing bacteria, autoantibody titers, lupus, autoimmune response, bacterial infection, murine model, systemic lupus erythematosus, immunology, autoimmunity, experimental mice, curli, antibody levels, disease exacerbation Lupus-prone mice, curliproducing bacteria, infection, autoantibody titers, control group, systemic lupus erythematosus, mouse model, bacterial infection, curli, immune response, autoimmunity, SLE, experimental mice, pathogenesis Lupus-prone mice, curli-producing bacteria, autoantibody titers, infection, autoimmune disease, systemic lupus erythematosus, bacterial infection, immune response, experimental model, bacterial amyloids, lupus mouse model, curli, autoimmunity, mouse experiment, microbial triggers, disease exacerbation Lupus-prone mice, Curli-producing bacteria, Autoantibody titers, Infection, Systemic lupus erythematosus, Mouse model, Immune response, Control group, Bacterial infection, Curli, Autoimmunity, Antibody production lupus-prone mice, curli-producing bacteria, infection, autoantibody titers, systemic lupus erythematosus, bacterial infection, mouse model, autoimmunity, immunology, disease exacerbation, SLE, experimental lupus, antibody production, microbial triggers, autoantibodies, control group, immune response, pathogenesis, lupus model, host-microbe interaction
1144	Taxation of sugar-sweetened beverages had no effect on the incidence rate of type II diabetes in India. taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, public health policy, diabetes prevalence, SSB tax, beverage consumption, diabetes risk factors, health economics, fiscal policy, non-communicable diseases taxation, sugar-sweetened beverages, type II diabetes, incidence rate, India, public health policy, diabetes prevention, beverage tax, sugar consumption, diabetes epidemiology, health impact, non-communicable diseases, Indian population taxation, sugar-sweetened beverages, type II diabetes, incidence rate, India, soda tax, diabetes prevention, public health policy, sugar consumption, health outcomes, beverage taxes, Indian population, epidemiology, disease incidence, tax impact taxation, sugar-sweetened beverages, incidence rate, type II diabetes, India, public health policy, diabetes prevention, sugar tax, epidemiology, beverage consumption, health impact, non-communicable diseases, Indian population, diabetes incidence, beverage taxation, SSB, policy evaluation taxation, sugar-sweetened beverages, SSB, type II diabetes, incidence rate, India, public health policy, diabetes prevention, beverage tax, health outcomes, epidemiology, sugar consumption, non-communicable diseases, India diabetes statistics, beverage taxation impact
723	Ly49Q directs the organization of neutrophil migration to inflammation sites by regulating membrane raft functions. Ly49Q, neutrophil migration, inflammation, membrane raft, organization, regulation, immune response, cell signaling, leukocyte trafficking, membrane microdomains Ly49Q, neutrophil migration, inflammation, membrane raft, regulation, immune response, cell signaling, leukocyte trafficking, chemotaxis, membrane microdomains, neutrophil function, Ly49 receptors, inflammation sites, immune cell migration, neutrophil recruitment Ly49Q, neutrophil migration, inflammation sites, membrane rafts, immune regulation, cell signaling, membrane microdomains, leukocyte trafficking, inflammation, innate immunity Ly49Q, neutrophil migration, inflammation, membrane raft, organization, regulation, immune response, cell signaling, leukocyte trafficking, membrane microdomains, innate immunity, chemotaxis, receptor function, lipid rafts, inflammatory sites Ly49Q, neutrophil migration, inflammation, membrane raft, raft function, immune cell trafficking, leukocyte chemotaxis, cell membrane organization, inflammatory response, immune regulation
845	Neutrophil extracellular traps (NETs) are released by ANCA-stimulated neutrophils. Neutrophil extracellular traps, NETs, ANCA, anti-neutrophil cytoplasmic antibodies, neutrophils, NET release, NETosis, immune response, autoimmunity, inflammation, ANCA-associated vasculitis, neutrophil activation Neutrophil extracellular traps, NETs, ANCA, antineutrophil cytoplasmic antibodies, neutrophils, NETosis, immune response, autoimmunity, NET release, NET formation, ANCA-stimulated neutrophils, inflammatory response, vasculitis, innate immunity neutrophil extracellular traps, NETs, ANCA, antineutrophil cytoplasmic antibodies, neutrophil activation, NETosis, NET release, autoimmune disease, inflammation, immunology, neutrophils, NET formation Neutrophil extracellular traps, NETs, ANCA, antineutrophil cytoplasmic antibodies, stimulated neutrophils, NETosis, neutrophil activation, extracellular DNA, inflammation, autoimmune diseases, vasculitis, immune response Neutrophil extracellular traps, NETs, ANCA, antineutrophil cytoplasmic antibodies, neutrophil activation, NETosis, autoimmunity, neutrophil degranulation, immune response, inflammatory diseases, vasculitis, MPO-ANCA, PR3-ANCA
967	Pretreatment with the Arp2/3 inhibitor CK-666 affects lamelliopodia formation. Arp2/3, CK-666, pretreatment, lamellipodia formation, actin polymerization, cell migration, cytoskeleton, inhibitor, actin dynamics, cell motility Arp2/3 inhibitor, CK-666, pretreatment, lamellipodia formation, actin cytoskeleton, cell migration, actin polymerization, cytoskeletal dynamics, cell motility, Arp2/3 complex, lamellipodia, actin branching, cellular protrusions, inhibitor effects Arp2/3 inhibitor, CK-666, pretreatment, lamellipodia formation, actin polymerization, cell migration, cytoskeleton, actin dynamics Arp2/3 inhibitor, CK-666, pretreatment, lamellipodia formation, actin cytoskeleton, cell migration, cytoskeletal dynamics, actin polymerization, cell motility, inhibition, lamellipodium, actin branching Arp2/3 inhibitor, CK-666, pretreatment, lamellipodia formation, actin cytoskeleton, cell motility, actin polymerization, cytoskeletal dynamics, Arp2/3 complex, cell migration
847	New drugs for tuberculosis often do not penetrate the necrotic portion of a tuberculosis lesion in high concentrations. tuberculosis, new drugs, drug penetration, necrotic lesion, lesion core, drug distribution, pharmacokinetics, granuloma, drug efficacy, tissue concentration, anti-tubercular agents, caseous necrosis, lesion microenvironment, antibiotic penetration new drugs, tuberculosis, drug penetration, necrotic lesion, high concentrations, tuberculous granuloma, caseous necrosis, drug delivery, pharmacokinetics, lesion microenvironment, antimicrobial therapy, drug distribution, TB treatment, lesion penetration tuberculosis, new drugs, drug penetration, necrotic lesion, lesion core, drug delivery, high concentration, pharmacokinetics, granuloma, drug efficacy, TB treatment, caseous necrosis, lesion microenvironment, tissue distribution, antimicrobial penetration tuberculosis, necrotic lesions, drug penetration, new drugs, lesion pharmacokinetics, drug distribution, TB treatment, necrosis, tissue concentration, drug efficacy tuberculosis, new drugs, necrotic lesions, drug penetration, lesion concentration, drug delivery, TB pharmacokinetics, caseous necrosis, antimicrobial distribution, TB treatment, pulmonary lesions, tissue penetration
727	Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts. Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, immune response, inflammation, monocyte differentiation, Ly6C expression, functional differences, mouse monocytes, immune modulation, myeloid cells, pro-inflammatory, anti-inflammatory, monocyte phenotypes Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, phenotype comparison, monocyte function, Ly6C expression, immunology Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, monocyte heterogeneity, immunology, inflammatory comparison, monocyte function, murine monocytes, innate immunity Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, monocytic differentiation, pro-inflammatory, anti-inflammatory, immunology, phenotypic comparison, monocyte function, Ly6C expression Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, immune response, mouse monocytes, inflammation, immunology, monocyte function, Ly6C expression, monocyte heterogeneity, pro-inflammatory, anti-inflammatory, myeloid cells, innate immunity
728	Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes. Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, monocyte function, Ly6C expression, pro-inflammatory, anti-inflammatory, monocyte phenotypes, immune cells, flow cytometry, murine monocytes, cytokine production, innate immunity, macrophage differentiation Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, monocyte inflammation, immune response, mouse monocytes, monocyte function, inflammation markers, monocyte phenotypes, immunology Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, immune response, inflammation, monocyte function, Ly6C expression, M1 monocytes, M2 monocytes, monocyte differentiation, cytokine production, immunology, murine monocytes, flow cytometry Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, functional differences, monocyte phenotypes, pro-inflammatory, anti-inflammatory, immunology, mouse monocytes, surface markers, monocyte activation, immune regulation Ly6C hi monocytes, Ly6C lo monocytes, inflammatory capacity, monocyte subsets, inflammation, immune response, monocyte plasticity, Ly6C expression, murine monocytes, monocyte activation
729	Lymphadenopathy is observed in knockin mouse lacking the SHP-2 MAPK pathway. lymphadenopathy, knockin mouse, SHP-2 deficiency, SHP-2 knockout, MAPK pathway, altered lymph nodes, genetic mouse model, SHP2, mitogen-activated protein kinase, immune phenotype, lymphatic system, mouse genetics, SHP2 disruption, mouse immunology lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, deficiency, mice model, SHP2 knockout, lymph node enlargement, signal transduction, mouse genetics, immune response, SHP-2 mutation, pathogenesis, molecular pathway, murine model lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, knockout model, mouse model, SHP2 deficiency, lymph node enlargement, signal transduction, immune response, genetic modification, pathway disruption lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, SHP2 knockout, lymph node enlargement, mouse model, signal transduction, immune phenotype, genetic mutation, PTPN11, murine, lymphatic abnormalities lymphadenopathy, knockin mouse, SHP-2, MAPK pathway, mouse model, genetic knockout, immune response, lymph node enlargement, SHP-2 deficiency, signaling pathway, hematopoiesis, mouse phenotype, immunology, molecular pathology
1163	The DdrB protein from Deinococcus radiodurans is an alternative SSB. DdrB, Deinococcus radiodurans, alternative SSB, single-stranded DNA-binding protein, SSB protein, DNA repair, radiation resistance, DNA protection, bacterial DNA-binding proteins, genome stability DdrB, Deinococcus radiodurans, alternative SSB, single-stranded DNA-binding protein, DNA repair, radiation resistance, SSB protein, DdrB function, Deinococcus proteins, DNA-binding proteins DdrB, Deinococcus radiodurans, alternative SSB, single-stranded DNA binding protein, DNA repair, DNA binding, radiation resistance, homolog, SSB protein, genome stability DdrB, Deinococcus radiodurans, single-stranded DNA-binding protein, SSB, alternative SSB, DNA repair, DdrB function, extremophile, radiation resistance, DdrB structure DdrB, protein, Deinococcus radiodurans, alternative SSB, single-stranded DNA-binding protein, DNA repair, radiation resistance, SSB protein, genome stability, DNA protection
1041	Replacement of histone H2A with H2A.Z slows gene activation in yeasts by stabilizing +1 nucleosomes. histone H2A, H2A.Z, gene activation, yeasts, nucleosome stability, +1 nucleosome, chromatin remodeling, transcription regulation, epigenetics, histone variant, nucleosome dynamics, gene expression, yeast genetics histone H2A, H2A.Z, gene activation, yeast, nucleosome stability, +1 nucleosome, histone replacement, chromatin remodeling, transcription regulation, epigenetics, nucleosome positioning, Saccharomyces cerevisiae, gene expression, nucleosome dynamics, histone variant histone H2A, H2A.Z, gene activation, yeast, +1 nucleosome, nucleosome stability, chromatin remodeling, histone replacement, transcription regulation, epigenetics, Saccharomyces cerevisiae, gene expression, nucleosome dynamics histone H2A, H2A.Z, gene activation, yeast, nucleosome stabilization, +1 nucleosome, chromatin remodeling, transcription regulation, histone replacement, epigenetics histone replacement, H2A, H2A.Z, gene activation, yeast, +1 nucleosome, nucleosome stability, chromatin remodeling, transcription regulation, epigenetics, histone variants, Saccharomyces cerevisiae, nucleosome dynamics
171	Basophils counteract disease development in patients with systemic lupus erythematosus (SLE). basophils, systemic lupus erythematosus, SLE, disease development, immune regulation, autoimmune disease, pathogenesis, immunomodulation, inflammation, leukocytes, protective role, lupus, hematology, disease progression Basophils, systemic lupus erythematosus, SLE, disease development, immune response, autoimmune disease, immunoregulation, inflammation, basophil function, lupus pathogenesis, disease progression, immune cells, SLE patients, protective role, hematology Basophils, systemic lupus erythematosus, SLE, disease progression, immune modulation, disease counteraction, autoimmune disorders, basophil function, inflammation, immune response, lupus pathology, clinical outcomes, immunology, therapeutic targets basophils, disease counteraction, systemic lupus erythematosus, SLE, immune response, disease development, autoimmunity, inflammatory regulation, lupus, basophil function Basophils, systemic lupus erythematosus, SLE, disease modulation, immune response, autoimmune disease, disease progression, inflammation, immunoregulation, leukocytes, disease prevention, basophil function, lupus pathology, immune cells, clinical outcomes
1282	Therapeutic use of the drug Dapsone to treat pyoderma gangrenous is based on anecdotal evidence. Dapsone, therapeutic use, pyoderma gangrenosum, anecdotal evidence, treatment, drug therapy, efficacy, clinical outcomes, case reports, dermatology, immunosuppressive agents, skin ulcers Dapsone, therapeutic use, pyoderma gangrenosum, anecdotal evidence, drug therapy, treatment, clinical evidence, dermatology, off-label use, effectiveness, case reports, immunosuppressive therapy, inflammatory skin disease Dapsone, therapeutic use, pyoderma gangrenosum, anecdotal evidence, drug treatment, dermatology, case reports, efficacy, off-label use, skin ulcers, immunosuppressive therapy Dapsone, therapeutic use, pyoderma gangrenosum, anecdotal evidence, treatment, drug therapy, clinical evidence, case reports, immunosuppressive therapy, dermatology Dapsone, pyoderma gangrenosum, therapeutic use, anecdotal evidence, treatment, drug therapy, effectiveness, case reports, off-label use, dermatology
1281	The ureABIEFGH gene cluster is induced by nickel (II) ion. ureABIEFGH, gene cluster, nickel induction, Ni(II), nickel-responsive genes, gene regulation, nickel ions, bacterial gene expression, operon, metal ion induction, urease genes, nickel regulation, transcriptional activation, metalloregulation ureABIEFGH gene cluster, nickel(II) ion, gene induction, nickel responsive genes, urease genes, gene expression regulation, metalloregulation, nickel ion sensing, microbial genetics, transcriptional activation ureABIEFGH gene cluster, nickel(II) ion, gene induction, urease genes, nickel regulation, bacterial gene expression, metal ion response, urease operon, gene cluster regulation, nickel-responsive genes ureABIEFGH gene cluster, nickel(II) induction, nickel ion, gene expression, urease genes, transcriptional regulation, metal ion induction, bacterial urease, nickel-responsive genes, gene regulation, nickel-responsive operon ureABIEFGH gene cluster, nickel(II) ion, gene induction, nickel-responsive genes, urease genes, gene regulation, metalloregulation, bacterial gene expression, nickel sensing, urease operon, metal ion regulation, nickel-induced expression, urea metabolism, transcriptional activation, nickel uptake
294	Crossover hot spots are not found within gene promoters in Saccharomyces cerevisiae. crossover hot spots, gene promoters, Saccharomyces cerevisiae, meiotic recombination, recombination hot spots, yeast genetics, promoter regions, absence, distribution, genomic locations crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, meiosis, genome, yeast, hotspot distribution, promoter regions, crossover frequency crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, meiosis, yeast genetics, DNA hotspots, genetic recombination sites, crossover frequency, promoter regions crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, meiotic recombination, chromosomal hotspots, yeast genetics, promoter regions, crossover frequency, hot spot distribution, genome organization crossover hot spots, gene promoters, Saccharomyces cerevisiae, recombination, meiotic recombination, chromosomal crossover, yeast genetics, promoter regions, genetic hotspots, recombination sites, genome organization
1280	The ureABIEFGH gene cluster encodes urease maturation proteins : UreD/UreH, UreE, UreF, and UreG. ureABIEFGH, gene cluster, urease maturation, urease accessory proteins, UreD, UreH, UreE, UreF, UreG, bacterial urease, enzyme maturation, gene encoding, operon, structural genes, urease biogenesis, prokaryotic urease ureABIEFGH, gene cluster, urease maturation, UreD, UreH, UreE, UreF, UreG, urease accessory proteins, microbial urease, urease assembly, operon, genetic regulation, enzyme maturation, bacterial genes ureABIEFGH, gene cluster, urease, maturation proteins, UreD, UreH, UreE, UreF, UreG, bacterial urease, gene expression, operon, protein encoding, urease accessory proteins ureABIEFGH gene cluster, urease maturation proteins, UreD, UreH, UreE, UreF, UreG, bacterial urease genes, urease accessory proteins, hydrogenase, nickel incorporation, operon, gene regulation, enzyme maturation ureABIEFGH, gene cluster, urease maturation, UreD, UreH, UreE, UreF, UreG, maturation proteins, urease biosynthesis, gene expression, bacterial urease, protein complex, accessory proteins, molecular genetics, operon
295	Crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) is important in the regulation of intestinal homeostasis. dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, gut immunity, mucosal immunity, cell-cell interaction, gastrointestinal tract, immune system, immune cell communication dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, gut immunity, cell interaction, mucosal immunity, gastrointestinal tract, immune cells, cytokine signaling, inflammation, tissue homeostasis dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, interaction, intestinal homeostasis, gut immune regulation, mucosal immunity, immune cell communication, gastrointestinal tract, immune regulation, immune system, intestinal immunity dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, gut immunity, mucosal immunity, cell-cell interaction, gut homeostasis, immune signaling, gastrointestinal tract dendritic cells, DCs, innate lymphoid cells, ILCs, crosstalk, intestinal homeostasis, immune regulation, gut immunity, mucosal immunity, cell-cell interaction
298	Cytochrome c is released from the mitochondrial intermembrane space to cytosol during apoptosis. cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, release, mitochondrial membrane permeabilization, cell death, intrinsic pathway, mitochondrial apoptosis, pro-apoptotic factors, caspase activation, mitochondrial outer membrane permeabilization, MOM permeabilization, apoptosis signaling, cell signaling cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, release, intrinsic pathway, cell death, mitochondria, pro-apoptotic, caspase activation cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, protein release, mitochondrial apoptosis pathway, intrinsic apoptosis, cell death, mitochondria, caspase activation, pro-apoptotic factors, mitochondrial outer membrane permeabilization cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, cytochrome c release, mitochondrial apoptosis, intrinsic pathway, mitochondria, cell death, caspase activation cytochrome c, mitochondrial intermembrane space, cytosol, apoptosis, release, intrinsic pathway, mitochondrial membrane permeability, cell death, mitochondrial-mediated apoptosis, pro-apoptotic proteins, caspase activation, mitochondrial outer membrane permeabilization, MOMP
179	Birth-weight is positively associated with breast cancer. birth-weight, breast cancer, epidemiology, risk factors, perinatal factors, birth weight association, neonatal factors, cancer risk, early life influences, prenatal determinants, breast cancer etiology, birth size, maternal factors birth-weight, breast cancer, association, positive correlation, perinatal factors, fetal growth, cancer risk, epidemiology, early-life factors, birth outcomes, neonatal weight, disease risk birth-weight, breast cancer, association, risk factors, epidemiology, perinatal factors, prenatal influences, cancer risk, birth size, infant weight, maternal health, early life factors, breast neoplasms, etiology, developmental origins birth-weight, breast cancer, positive association, perinatal factors, epidemiology, cancer risk, birthweight, breast neoplasms, early life exposure, infant size, birth weight and cancer birth-weight, breast cancer, association, risk factor, epidemiology, neonatal factors, cancer risk, perinatal influences, early life exposures, prenatal development, birth size, maternal factors, infant health, developmental origins, oncology
971	Primary cervical cancer screening with HPV detection has higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2, cervical cancer, screening methods, HPV testing, sensitivity comparison, cervical neoplasia detection, cytology screening Primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2, cervical cancer, HPV testing, cytology screening, cervical precancer, sensitivity comparison, screening methods primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, HPV testing, cervical screening methods, sensitivity comparison, cytology versus HPV, cervical neoplasia detection, cervical cancer biomarkers primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia grade 2, CIN2, HPV screening, cervical cancer biomarkers, screening methods, sensitivity comparison primary cervical cancer screening, HPV detection, longitudinal sensitivity, conventional cytology, cervical intraepithelial neoplasia, CIN2, cervical screening methods, HPV testing, cervical neoplasia detection, sensitivity comparison, cervical dysplasia
1279	The treatment of cancer patients with co-IR blockade precipitates adverse autoimmune events. cancer, co-IR blockade, immune checkpoint inhibitors, treatment, autoimmune events, adverse effects, immunotherapy, cancer patients, immune-related toxicity, side effects, autoimmune complications cancer, co-IR blockade, immune checkpoint inhibitors, treatment, autoimmune events, adverse effects, immunotherapy, side effects, cancer patients, toxicity, immune-related adverse events, co-inhibitory receptor, immunotoxicity cancer, co-IR blockade, immune checkpoint inhibitors, treatment, autoimmune events, adverse effects, immunotherapy, toxicity, immune-related adverse events, cancer immunotherapy, checkpoint blockade, autoimmunity, side effects, patient outcomes, oncology cancer treatment, co-IR blockade, immune checkpoint inhibitors, autoimmune adverse events, immunotherapy, immune-related toxicity, cancer immunotherapy side effects, checkpoint inhibitor-related autoimmunity, co-inhibitory receptor blockade, immune-mediated adverse events cancer, co-IR blockade, cancer treatment, immunotherapy, adverse autoimmune events, immune checkpoint inhibitors, therapy side effects, immune-related toxicity, cancer immunology, autoimmunity, checkpoint inhibition, oncological adverse events
1278	The treatment of cancer patients with co-IR blockade does not cause any adverse autoimmune events. cancer treatment, co-IR blockade, immune checkpoint inhibitors, autoimmune events, adverse effects, cancer immunotherapy, safety profile, side effects, immune-related toxicity, patient outcomes cancer treatment, co-IR blockade, immune checkpoint inhibitors, autoimmune events, adverse events, immunotherapy, cancer patients, safety, toxicity, immune-related adverse effects, side effects, cancer immunotherapy, autoimmune toxicity, checkpoint inhibitor, patient outcomes cancer treatment, co-IR blockade, immune checkpoint inhibitors, adverse autoimmune events, safety, immunotherapy, cancer patients, side effects, toxicity, immune-related adverse events, clinical outcomes, co-inhibitory receptor blockade cancer treatment, co-IR blockade, immune checkpoint inhibitors, autoimmune adverse events, safety, immunotherapy, toxicity, side effects, cancer patients, immune response cancer treatment, co-IR blockade, immune checkpoint inhibitors, adverse events, autoimmune toxicity, cancer immunotherapy, safety, immune-related side effects, co-inhibitory receptor blockade, patient outcomes
852	Non-invasive ventilation use should be decreased if there is inadequate response to conventional treatment. non-invasive ventilation, inadequate response, conventional treatment, ventilation reduction, respiratory failure, treatment escalation, medical management, NIV discontinuation, ventilatory support, respiratory therapy non-invasive ventilation, ventilation use, decrease use, inadequate response, conventional treatment, ventilation management, respiratory failure, NIV indications, escalation of care, treatment response, respiratory support, therapy adjustment non-invasive ventilation, inadequate response, conventional treatment, ventilation use, respiratory failure, weaning, treatment efficacy, NIV, escalation of care, respiratory support, clinical decision-making, ventilation adjustment non-invasive ventilation, inadequate response, conventional treatment, decrease use, ventilation management, respiratory failure, NIV, treatment response, respiratory therapy, clinical guidelines non-invasive ventilation, inadequate response, conventional treatment, ventilation use, reduce use, respiratory support, treatment failure, clinical response, escalation of care, mechanical ventilation, respiratory insufficiency, NIV, therapy adjustment
975	Primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators. primary cytokines, pro-inflammatory, cytokine induction, secondary mediators, pro-inflammatory mediators, anti-inflammatory mediators, immune response, cytokine signaling, mediator induction, inflammation primary cytokines, pro-inflammatory cytokines, secondary mediators, pro-inflammatory mediators, anti-inflammatory mediators, cytokine induction, immune response, inflammation, cytokine signaling, mediator induction primary cytokines, pro-inflammatory, induce, secondary mediators, anti-inflammatory, cytokine signaling, immune response, inflammatory mediators, cytokine cascade, immunomodulation primary cytokines, pro-inflammatory cytokines, secondary mediators, pro-inflammatory mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, cytokine signaling, immune regulation, cytokine cascade primary pro-inflammatory cytokines, secondary mediators, pro-inflammatory mediators, anti-inflammatory mediators, cytokine induction, inflammatory response, cytokine signaling, immune regulation, cytokine cascade, mediator production
613	Increased microtubule acetylation repairs LRRK2 Roc-COR domain mutation induced locomotor deficits. microtubule acetylation, LRRK2 mutation, Roc-COR domain, locomotor deficits, neurodegeneration, Parkinson’s disease, cytoskeleton, axonal transport, therapeutic targets, neuronal repair microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neurodegeneration, Parkinson’s disease, motor function, tubulin modification, neuronal repair, movement disorder, therapeutic targets, protein acetylation, molecular mechanisms, disease models microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, neurodegeneration, Parkinson's disease, cytoskeleton, neuronal repair, molecular mechanisms microtubule acetylation, LRRK2, Roc-COR domain, locomotor deficits, mutation, neurodegeneration, repair mechanisms, Parkinson's disease, motor function, cytoskeleton, protein acetylation, neuronal recovery, LRRK2 mutation, cellular mechanisms microtubule acetylation, LRRK2, Roc-COR domain, mutation, locomotor deficits, repair, neurodegeneration, Parkinson’s disease, microtubules, acetylation, LRRK2 mutation, motor impairment, neuronal repair
70	Activation of PPM1D suppresses p53 function. PPM1D, activation, p53, suppression, WIP1, tumor suppressor, phosphatase, DNA damage response, oncogenesis, cell cycle, apoptosis, cancer, p53 pathway, negative regulation, TP53 PPM1D, activation, p53 suppression, p53 inhibition, WIP1, tumor suppressor, oncogenesis, phosphatase, DNA damage response, cancer, cell cycle regulation, apoptosis, TP53, stress response PPM1D, activation, p53, suppression, Wip1, tumor suppressor, cancer, cell cycle, DNA damage response, negative regulation, oncogenesis, protein phosphatase, transcriptional activity PPM1D activation, p53 suppression, WIP1, p53 pathway, PPM1D phosphatase, tumor suppressor, oncogenic signaling, cell cycle regulation, DNA damage response, p53 inactivation PPM1D activation, p53 suppression, Wip1, p53 inactivation, tumor suppressor, DNA damage response, phosphatase, oncogenesis, cell cycle regulation, cancer, TP53, PPM1D-p53 interaction, apoptosis, phosphorylation, PPM1D overexpression
72	Activator-inhibitor pairs are provided dorsally by Admpchordin. activator-inhibitor pairs, dorsal patterning, Admp, chordin, embryonic development, morphogen gradient, dorsal signaling, developmental biology, self-regulation, BMP signaling, zebrafish, pattern formation activator-inhibitor pairs, dorsal, Admp, chordin, morphogen, pattern formation, embryonic development, signaling, dorsal-ventral patterning, gene regulation activator-inhibitor, dorsal patterning, Admp, chordin, embryogenesis, morphogen gradients, developmental biology, dorsal signaling, BMP antagonists, molecular pairs, dorsal-ventral axis, gene regulation, signaling pathways, tissue differentiation activator-inhibitor, dorsal patterning, Admp, chordin, embryonic development, developmental biology, dorsal signaling, morphogen gradients, protein interaction, zebrafish, vertebrate axis formation, BMP signaling, dorsal organizer activator-inhibitor pairs, Admp, chordin, dorsal, patterning, embryogenesis, developmental biology, morphogen gradients, signaling pathways, dorsoventral axis, organizer, BMP signaling, zebrafish, vertebrate development
859	Normal expression of RUNX1 has tumor-promoting effects. RUNX1, normal expression, tumor-promoting, oncogenesis, cancer progression, transcription factors, oncogenic activity, malignancy, gene regulation, tumor biology RUNX1, normal expression, tumor-promoting effects, oncogenesis, cancer progression, gene regulation, tumorigenesis, cancer biomarkers, transcription factors, cellular proliferation RUNX1, normal expression, tumor-promoting, oncogenesis, cancer, gene expression, transcription factor, malignancy, tumorigenesis, cancer progression, RUNX1 function, cellular proliferation, oncogenic role RUNX1, normal expression, tumor-promoting, oncogenesis, cancer progression, gene regulation, tumor growth, transcription factor, malignancy, cell proliferation RUNX1, normal expression, tumor-promoting, oncogenic effects, cancer, gene regulation, tumor progression, malignancy, hematological malignancies, transcription factor, cancer biology, cell proliferation, oncogenesis, tumorigenesis
619	Increased vessel density along with a reduction in fibrosis decreases the efficacy of chemotherapy treatments. vessel density, fibrosis, chemotherapy efficacy, tumor microenvironment, tumor vasculature, drug resistance, cancer treatment, angiogenesis, extracellular matrix, stromal changes vessel density, fibrosis reduction, chemotherapy efficacy, tumor microenvironment, drug resistance, angiogenesis, cancer treatment, stromal changes, tissue remodeling, vascularization, therapeutic response vessel density, fibrosis reduction, chemotherapy efficacy, tumor microenvironment, angiogenesis, cancer treatment resistance, extracellular matrix, drug delivery, tumor fibrosis, blood vessels, chemotherapy resistance, stromal changes vessel density, fibrosis reduction, chemotherapy efficacy, tumor microenvironment, cancer treatment resistance, angiogenesis, fibrotic tissue, drug delivery, vascularization, tumor fibrosis, therapeutic response, cancer stroma vessel density, fibrosis reduction, chemotherapy efficacy, tumor microenvironment, angiogenesis, drug resistance, cancer treatment, stromal remodeling, vascularization, extracellular matrix, therapeutic response, tumor vasculature, fibrosis, chemotherapy resistance, tissue remodeling
75	Active H. pylori urease has a polymeric structure that compromises two subunits, UreA and UreB. Active H. pylori urease, polymeric structure, UreA subunit, UreB subunit, Helicobacter pylori, urease enzyme, protein subunits, enzyme structure, bacterial urease, H. pylori virulence, urease composition H. pylori, urease, polymeric structure, UreA, UreB, subunits, active enzyme, Helicobacter pylori, enzyme structure, protein complex, urease subunits H. pylori, urease, polymeric structure, UreA, UreB, subunits, Helicobacter pylori, enzyme structure, urease activity, protein complex, molecular composition, bacterial urease H. pylori, urease, polymeric structure, UreA, UreB, enzyme subunits, active urease, structural biology, Helicobacter pylori, protein complex, microbial enzymes, protein subunits H. pylori, urease, polymeric structure, UreA, UreB, subunits, active enzyme, Helicobacter pylori, enzyme structure, protein subunits, bacterial urease
1175	The PPR MDA5 has two N-terminal CARD domains. PPR, MDA5, N-terminal, CARD domains, protein structure, innate immunity, RNA sensing, antiviral response, CARD motif, domain architecture PPR, MDA5, N-terminal, CARD domains, protein structure, innate immunity, receptor, double-stranded RNA, antiviral response, signaling pathway PPR, MDA5, N-terminal, CARD domains, protein domains, innate immunity, RNA sensing, interferon response, domain architecture, molecular structure PPR, MDA5, N-terminal, CARD domains, protein structure, domain architecture, innate immunity, viral RNA sensor, interferon signaling, double-stranded RNA, CARD, protein domains PPR, MDA5, N-terminal, CARD domains, protein structure, innate immunity, domain architecture, antiviral response, RNA sensor, double-stranded RNA, pattern recognition receptor
180	Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 leads to increased TDP-43-induced neuronal loss. TDP-43, interaction blocking, respiratory complex I, ND3, ND6, neuronal loss, neurodegeneration, protein interaction, mitochondrial dysfunction, neurotoxicity, TDP-43 pathology, neuron death, mitochondrial proteins TDP-43, respiratory complex I, ND3, ND6, protein interaction, neuronal loss, neurodegeneration, blocking interaction, mitochondria, mitochondrial dysfunction, neurotoxicity, TDP-43 pathology, protein-protein interaction, neuronal death, neurobiology TDP-43, respiratory complex I, ND3, ND6, neuronal loss, protein interaction, inhibition, neurodegeneration, mitochondrial dysfunction, neurotoxicity, protein aggregation TDP-43, neuronal loss, respiratory complex I, ND3, ND6, protein interaction, blocking, neurodegeneration, mitochondrial dysfunction, neuroprotection, TDP-43 pathology, neuron survival, protein-protein interaction, mitochondrial complex I, ALS, frontotemporal dementia TDP-43, respiratory complex I, ND3, ND6, interaction blocking, neuronal loss, neurodegeneration, protein-protein interaction, mitochondrial dysfunction, TDP-43 toxicity, neuron death, complex I subunits
183	Bone marrow cells contribute to adult macrophage compartments. bone marrow cells, adult macrophages, macrophage compartments, hematopoiesis, myeloid lineage, monocyte differentiation, cell contribution, tissue-resident macrophages, immune cell development, ontogeny, progenitor cells, macrophage origin bone marrow cells, adult macrophage, macrophage compartments, hematopoiesis, monocyte differentiation, immune system, cell lineage, myeloid cells, tissue macrophages, cell contribution, bone marrow derived, macrophage development bone marrow cells, adult macrophage, macrophage compartments, hematopoiesis, myeloid lineage, monocyte differentiation, immune system, tissue macrophages, cellular contribution, progenitor cells, adult hematopoiesis, macrophage origin bone marrow cells, adult macrophages, macrophage compartments, hematopoiesis, monocyte differentiation, immune cells, macrophage origin, cell contribution, bone marrow-derived macrophages, tissue macrophages bone marrow cells, adult macrophages, macrophage compartments, hematopoiesis, myeloid differentiation, cell lineage, immune cells, progenitor cells, monocytes, tissue macrophages, cellular contribution, adult tissue, origin of macrophages, bone marrow-derived cells
1292	There is no association between HNF4A mutations and diabetes risks. HNF4A mutations, diabetes risk, association, genetic mutations, diabetes susceptibility, HNF4A gene, diabetes genetics, mutation impact, type 2 diabetes, risk factors, genetic association, diabetes development HNF4A, mutations, diabetes, risk, association, genetic association, diabetes mellitus, HNF4A gene, absence, correlation, negative result, genetic risk, non-association HNF4A, mutations, diabetes, risk, association, genetic, variant, susceptibility, relationship, type 2 diabetes, gene, linkage, epidemiology, negative result, non-association HNF4A mutations, diabetes risk, HNF4A gene, genetic association, diabetes susceptibility, HNF4A and diabetes, gene mutation, no correlation, diabetes genetics, HNF4A variants, non-association, heredity, molecular genetics, type 2 diabetes, monogenic diabetes HNF4A mutations, diabetes risk, genetic association, HNF4A gene, diabetes susceptibility, mutation impact, genetic risk factors, diabetes genetics, HNF4A variant, type 2 diabetes, type 1 diabetes, negative association, non-association, HNF4A and diabetes, gene-disease relationship
185	Breast cancer development is determined exclusively by genetic factors. breast cancer, cancer development, genetic factors, hereditary risk, genetics, breast cancer etiology, genetic predisposition, gene mutations, BRCA genes, hereditary breast cancer, cancer risk factors breast cancer, cancer development, genetic factors, genetics, hereditary, risk factors, tumorigenesis, gene mutations, oncogenes, BRCA1, BRCA2, familial breast cancer, inherited predisposition, DNA mutations, genetic predisposition breast cancer, development, genetic factors, hereditary, genetics, risk factors, gene mutations, BRCA1, BRCA2, tumor suppressor genes, oncogenes, DNA, gene expression, etiology, causation, molecular mechanisms breast cancer, cancer development, genetic factors, hereditary, genetics, risk factors, etiology, gene mutations, BRCA1, BRCA2, breast neoplasms, oncogenes, tumor suppressor genes, molecular genetics breast cancer, cancer development, genetic factors, genetic determinants, breast cancer genetics, hereditary breast cancer, cancer risk factors, genetic predisposition, inherited cancer, genetics vs environment, breast cancer etiology, exclusive genetic influence, genetic causality
1290	There is an inverse relationship between hip fractures and statin use. hip fractures, statin use, inverse relationship, osteoporosis, bone mineral density, fracture risk, cholesterol-lowering drugs, elderly, bone health, statins, epidemiology, prevention, cardiovascular drugs, pharmacoepidemiology, geriatric medicine hip fractures, statin use, inverse relationship, osteoporosis, bone density, fracture risk, statins, elderly, lipid-lowering drugs, bone health, epidemiology, risk reduction, musculoskeletal effects, cardiovascular medication, clinical studies hip fractures, statin use, inverse relationship, statins, bone health, osteoporosis, fracture risk, cholesterol-lowering drugs, epidemiology, elderly, musculoskeletal, bone density hip fractures, statin use, inverse relationship, osteoporosis, bone health, fracture risk, cholesterol-lowering drugs, elderly, bone mineral density, statins, risk reduction, epidemiology, preventive therapy, musculoskeletal health, aging population hip fractures, statin use, inverse relationship, osteoporosis, bone density, fracture risk, cholesterol-lowering drugs, statins, elderly, prevention, bone health, epidemiology, observational studies, medication effect, fall risk
1049	Ribosomopathies have a low degree of cell and tissue specific pathology. ribosomopathies, cell specificity, tissue specificity, pathology, disease mechanism, ribosome disorders, cellular pathology, tissue pathology, specificity, ribosomal diseases, clinical manifestations, phenotype, tissue tropism, ribosome dysfunction, genetic disorders ribosomopathies, cell specificity, tissue specificity, pathology, low specificity, selective pathology, ribosome disorders, cellular pathology, tissue pathology, disease mechanisms, organ specificity ribosomopathies, cell specificity, tissue specificity, pathology, disease mechanisms, ribosome dysfunction, selective vulnerability, phenotype variability, cellular pathology, tissue pathology ribosomopathies, cell specificity, tissue specificity, pathology, ribosome disorders, disease mechanisms, selective vulnerability, clinical heterogeneity, molecular basis, pathophysiology, phenotype variability, ribosome function, genetic disorders ribosomopathies, cell specificity, tissue specificity, pathology, disease mechanisms, ribosome disorders, molecular basis, phenotypic variability, cell-type specificity, tissue-specific pathology, ribosome dysfunction, genetic disorders, ribosomal diseases, clinical manifestations, organ specificity
982	Proteins synthesized at the growth cone are ubiquitinated at a higher rate than proteins from the cell body. protein synthesis, growth cone, ubiquitination, cell body, protein degradation, neuronal proteins, axonal translation, protein turnover, localized translation, neuron, synaptic plasticity, axon, proteostasis proteins, growth cone, ubiquitination, synthesis, cell body, protein degradation, neuronal proteins, local protein synthesis, ubiquitin, axonal transport, neurobiology, protein turnover proteins, growth cone, synthesis, ubiquitination, cell body, protein degradation, neuronal proteins, local translation, axon, protein turnover proteins, growth cone, ubiquitination, higher rate, cell body, protein synthesis, neuronal proteins, localized translation, protein degradation, axonal proteins, nerve cells, subcellular localization protein synthesis, growth cone, ubiquitination, cell body, rate comparison, neuronal proteins, local translation, protein degradation, neurobiology, protein turnover
742	Macrolides have no protective effect against myocardial infarction. macrolides, myocardial infarction, protective effect, antibiotic therapy, cardiovascular risk, heart attack, macrolide antibiotics, cardiac outcomes, MI prevention, drug safety, negative findings, clinical studies, cardiovascular events macrolides, myocardial infarction, protective effect, cardiovascular risk, antibiotics, heart attack, macrolides efficacy, antibiotic therapy, cardiovascular outcomes, myocardial protection, cardiovascular events, macrolides association, macrolide antibiotics, heart disease macrolides, myocardial infarction, protective effect, cardiovascular risk, antibiotics, heart attack, drug safety, antibiotic cardiovascular effects, macrolide no effect, myocardial protection, macrolide and heart, absence of benefit macrolides, protective effect, myocardial infarction, cardiovascular risk, antibiotic therapy, heart attack, macrolide antibiotics, MI prevention, cardiovascular outcomes, azithromycin, clarithromycin, erythromycin, cardiac events, negative results, clinical studies macrolides, protective effect, myocardial infarction, heart attack, cardiovascular risk, antibiotics, cardiac events, prevention, efficacy, clinical outcomes, negative association, cardiovascular disease
501	Headaches are not correlated with cognitive impairment. headaches, cognitive impairment, correlation, relationship, cognitive function, neurological symptoms, headache disorders, cognitive decline, migraine, memory, mental performance, neuropsychology, brain function, clinical studies, association, risk factors, cognitive health, headache impact headaches, cognitive impairment, correlation, association, cognitive decline, neurological disorders, headache impact, cognitive function, cognitive performance, headache studies, memory, attention, migraine, cognitive assessment, headache research headaches, cognitive impairment, correlation, relationship, association, neurological symptoms, cognitive function, headache disorders, cognitive decline, cognitive performance, neuropsychology, migraine, tension headache, cognitive assessment, brain function, mental impairment, symptom correlation headaches, cognitive impairment, correlation, association, cognitive function, neurological symptoms, cognitive decline, headache disorders, memory, cognition, mental performance, headache impact, neuropsychology headaches, cognitive impairment, correlation, association, neurological symptoms, headache impact, cognitive function, headache research, cognitive decline, headache studies, no correlation, migraine, memory, cognition, neurological disorders
743	Macrolides protect against myocardial infarction. macrolides, myocardial infarction, cardioprotection, heart attack, antibiotic therapy, cardiovascular events, cardiac protection, MI prevention, anti-inflammatory, azithromycin, clarithromycin, erythromycin, cardiovascular risk, infection, heart disease prevention macrolides, myocardial infarction, heart attack, cardioprotection, antibiotic therapy, cardiovascular protection, azithromycin, clarithromycin, erythromycin, cardiac events, coronary artery disease, inflammation, atherosclerosis, cardiovascular risk, antibiotic effects macrolides, myocardial infarction, cardioprotection, antibiotics, heart attack prevention, cardiovascular risk, myocardial infarction protection, erythromycin, azithromycin, clarithromycin, coronary event prevention, macrolide therapy, cardiac benefits, acute coronary syndrome, antibiotic cardiovascular effects macrolides, myocardial infarction, heart attack, cardioprotection, antibiotic therapy, cardiovascular protection, macrolide antibiotics, acute coronary syndrome, cardiac events, MI prevention, azithromycin, clarithromycin, erythromycin macrolides, myocardial infarction, heart attack, cardiovascular protection, antibiotic therapy, cardioprotection, macrolide antibiotics, acute coronary syndrome, cardiovascular risk, MI prevention, erythromycin, azithromycin, clarithromycin
985	Pseudogene PTENP1 regulates the expression of PTEN by functioning as an miRNA decoy. PTENP1, pseudogene, PTEN, miRNA decoy, gene regulation, microRNA, ceRNA, competitive endogenous RNA, gene expression, non-coding RNA, PTEN regulation, post-transcriptional regulation, transcript sponge, RNA interaction, PTENP1 function PTENP1, pseudogene, PTEN, miRNA decoy, microRNA sponge, gene regulation, non-coding RNA, competing endogenous RNA, ceRNA, post-transcriptional regulation, tumor suppressor, gene expression, RNA interference, cancer, molecular mechanism PTENP1, pseudogene, PTEN, gene regulation, miRNA decoy, microRNA sponge, ceRNA, competing endogenous RNA, gene expression, post-transcriptional regulation, non-coding RNA, PTENP1 function, PTEN regulation, molecular mechanism PTENP1, pseudogene, PTEN, miRNA decoy, microRNA sponge, gene regulation, competing endogenous RNA, ceRNA, post-transcriptional regulation, noncoding RNA, miRNA interaction, tumor suppressor, gene expression, molecular mechanism, RNA-mediated regulation PTENP1, pseudogene, PTEN, regulation, gene expression, miRNA decoy, competing endogenous RNA, ceRNA, microRNA, molecular mechanism, post-transcriptional regulation, RNA interactions, PTEN regulation
502	Healthcare delivery efficiency in crowded delivery centers is impaired by improving structural, logistical, and interpersonal elements. healthcare delivery efficiency, crowded delivery centers, structural factors, logistical factors, interpersonal factors, healthcare improvement, patient flow, healthcare logistics, hospital crowding, service delivery, provider-patient interaction, workflow optimization healthcare delivery efficiency, crowded delivery centers, structural factors, logistical factors, interpersonal factors, healthcare workflow, hospital overcrowding, patient flow, operational efficiency, healthcare management, delivery center optimization, healthcare logistics, staff-patient communication, patient safety, resource allocation healthcare delivery, efficiency, crowded delivery centers, structural factors, logistical factors, interpersonal factors, healthcare quality, care coordination, workflow optimization, patient flow, resource allocation, communication, hospital management, service improvement, delivery system, patient experience healthcare delivery efficiency, crowded delivery centers, structural elements, logistical elements, interpersonal elements, healthcare facility management, patient flow, resource allocation, healthcare logistics, staff communication, patient care quality, healthcare process improvement healthcare delivery, efficiency, crowded delivery centers, structural factors, logistical factors, interpersonal elements, healthcare quality, hospital workflow, patient throughput, healthcare management, resource allocation, staff communication, healthcare infrastructure, process optimization, patient care
623	Individuals with low serum vitamin D concentrations have increased risk of multiple sclerosis. low serum vitamin D, vitamin D deficiency, multiple sclerosis risk, MS, vitamin D levels, epidemiology, autoimmune disease, risk factors, hypovitaminosis D, vitamin D and MS, disease susceptibility, neurological disorders low vitamin D, serum vitamin D, vitamin D deficiency, multiple sclerosis risk, MS risk factors, hypovitaminosis D, vitamin D and MS, serum 25-hydroxyvitamin D, autoimmune disease, neurologic disorders, vitamin D insufficiency, MS epidemiology vitamin D, serum vitamin D, low vitamin D, vitamin D deficiency, multiple sclerosis, MS, risk factors, epidemiology, autoimmune diseases, vitamin D and MS, vitamin D blood levels, neurological disorders, vitamin D status, vitamin D insufficiency, MS risk low serum vitamin D, vitamin D deficiency, multiple sclerosis risk, MS risk factors, low vitamin D, serum vitamin D levels, multiple sclerosis, autoimmune disease, vitamin D and MS, vitamin D insufficiency low serum vitamin D, vitamin D deficiency, increased risk, multiple sclerosis, MS, epidemiology, risk factors, autoimmune disease, vitamin D levels, neurodegenerative diseases
744	Macropinocytosis contributes to a cell's supply of amino acids via the intracellular uptake of protein. macropinocytosis, amino acids, protein uptake, intracellular transport, nutrient acquisition, endocytosis, cell metabolism, protein catabolism, lysosomal degradation, cellular nutrition, macromolecule internalization, amino acid supply macropinocytosis, amino acid supply, protein uptake, intracellular transport, cell nutrient acquisition, endocytosis, lysosomal degradation, cellular metabolism, protein catabolism, nutrient sensing, amino acid homeostasis, protein-derived amino acids macropinocytosis, amino acids, intracellular uptake, protein internalization, nutrient acquisition, endocytosis, cell metabolism, protein degradation, lysosomal processing, cellular nutrition, amino acid supply, protein catabolism macropinocytosis, amino acid supply, intracellular uptake, protein uptake, nutrient acquisition, endocytosis, cell metabolism, protein catabolism, lysosomal degradation, cellular nutrition, amino acid transport, protein internalization macropinocytosis, amino acid supply, intracellular uptake, protein uptake, nutrient acquisition, endocytosis, cell metabolism, lysosomal degradation, protein catabolism, cellular nutrition, macromolecule internalization, amino acid transport
507	Helminths interfere with immune system control of macrophages activated by IL-4 favor Mycobacterium tuberculosis replication. helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, replication, immune modulation, tuberculosis, parasite-host interaction, macrophage activation, interleukin-4, co-infection Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, immune modulation, helminth infection, tuberculosis, macrophage activation, co-infection, immune evasion, Th2 response, parasite-host interaction, intracellular replication, cytokines helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, immune modulation, tuberculosis replication, parasite infection, host-pathogen interaction, Th2 response, intracellular pathogens Helminths, immune system, macrophages, IL-4, Mycobacterium tuberculosis, immune modulation, parasite-host interaction, tuberculosis, immune evasion, macrophage activation, helminth infection, cytokines, coinfection, immune response, Th2 response helminths, immune system, macrophage activation, IL-4, Mycobacterium tuberculosis, replication, immune modulation, parasite-host interaction, tuberculosis, cytokines, Th2 response, infection, immunosuppression, host defense, T-cell response
628	Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of African origin. HTLV-1, human T-cell lymphotropic virus type 1, infection, African origin, prevalence, epidemiology, risk factors, geographic distribution, population genetics, virus transmission, endemic regions HTLV-1, human T-cell lymphotropic virus type 1, infection, prevalence, African origin, epidemiology, risk factors, transmission, demographic, distribution, population, ethnicity, endemic, Afro-descendant, viral infection HTLV-1, human T-cell lymphotropic virus type 1, infection, African origin, prevalence, epidemiology, population, frequency, distribution, risk factors HTLV-1, human T-cell lymphotropic virus type 1, infection, prevalence, African origin, epidemiology, risk factors, demographics, transmission, endemic regions HTLV-1, human T-cell lymphotropic virus type 1, infection, prevalence, African origin, epidemiology, risk factors, demographic distribution
508	Hematopoietic Stem Cell purification reaches purity rate of up to 50%. Hematopoietic Stem Cell, purification, purity rate, 50%, stem cell isolation, cell sorting, cell purification efficiency, hematopoiesis, progenitor cells, enrichment methods, FACS, MACS, stem cell therapy Hematopoietic Stem Cell, purification, purity rate, stem cell isolation, cell sorting, 50% purity, HSC enrichment, hematopoietic cell sorting, stem cell purification efficiency, stem cell yield, cell separation, flow cytometry, HSC purity, high-purity isolation, hematopoietic progenitor cells Hematopoietic Stem Cell, purification, purity rate, 50%, stem cell isolation, HSC, enrichment, cell sorting, cell separation, hematopoiesis, high purity, stem cell purification, enrichment methods, cell purification, flow cytometry, MACS, FACS Hematopoietic Stem Cell, purification, purity rate, 50%, stem cell isolation, hematopoiesis, cell sorting, stem cell enrichment, high purity, purified stem cells, cell separation, stem cell purification methods Hematopoietic Stem Cell, stem cell purification, purity rate, cell separation, HSC enrichment, purification methods, hematopoiesis, cell sorting, high purity stem cells, hematopoietic progenitors, stem cell isolation, 50% purity, stem cell biology, stem cell research, flow cytometry, magnetic separation
1187	The YAP1 and TEAD complex tanslocates into the nucleus where it interacts with transcription factors and DNA-binding proteins that modulate target gene transcription. YAP1, TEAD, complex, nuclear translocation, transcription factors, DNA-binding proteins, target gene transcription, gene regulation, protein interaction, nucleus, transcriptional activation, Hippo pathway YAP1, TEAD, complex, nucleus, translocation, transcription factors, DNA-binding proteins, gene transcription, target genes, protein interaction, Hippo pathway, transcriptional regulation YAP1, TEAD complex, nuclear translocation, transcription factors, DNA-binding proteins, gene regulation, target gene transcription, Hippo pathway, protein-protein interaction, transcriptional activation, chromatin remodeling YAP1, TEAD, complex, nuclear translocation, nucleus, transcription factors, DNA-binding proteins, gene transcription, target genes, protein interaction, transcription regulation, Hippo pathway, co-activators, cellular signaling YAP1, TEAD complex, nuclear translocation, transcription factors, DNA-binding proteins, gene transcription, target genes, Hippo pathway, transcriptional regulation, protein-protein interactions, cell signaling, gene expression, nucleus
1185	The US health care system can save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. US health care system, kidney transplant, cost savings, $750 million, 7% patients, national kidney paired donation program, optimized kidney exchange, health care savings, organ transplant efficiency, kidney donation economics US health care system, kidney transplants, cost savings, $750 million, 7% patients, national kidney paired donation program, optimized donation, transplant waiting list, health system efficiency, organ transplantation, paired kidney exchange, economic impact, healthcare cost reduction US health care system, cost savings, $750 million, 7% patients, kidney transplants, national kidney paired donation program, kidney exchange, organ transplant system, healthcare cost reduction, transplant waiting list, paired donation optimization US health care system, cost savings, $750 million, kidney transplant, patients, 7% participation, optimized, national kidney paired donation program, kidney exchange, healthcare economics, transplant program efficiency, organ donation, policy impact, health system savings US health care cost savings, kidney transplant, kidney paired donation program, $750 million savings, 7% patient participation, organ transplant cost reduction, national kidney exchange, health economics, transplant waitlist, health policy, organ allocation, cost-effectiveness, transplantation, donor matching, healthcare efficiency
1062	S-nitrosylated GAPDH physiologically transnitrosylates histone deacetylases. S-nitrosylated GAPDH, GAPDH, transnitrosylation, histone deacetylases, HDAC, S-nitrosylation, nitric oxide signaling, protein modification, epigenetic regulation, redox biology, enzymatic activity, post-translational modification, NO signaling, cellular signaling S-nitrosylated GAPDH, transnitrosylation, histone deacetylases, HDAC, nitrosylation, post-translational modification, protein S-nitrosylation, cellular signaling, GAPDH function, enzyme regulation, nitric oxide signaling S-nitrosylated GAPDH, GAPDH, transnitrosylation, histone deacetylases, HDAC, S-nitrosylation, nitric oxide signaling, protein S-nitrosylation, cellular signaling, epigenetic regulation, NO-mediated modification, post-translational modification, nuclear signaling, enzyme-substrate interaction S-nitrosylated GAPDH, transnitrosylation, histone deacetylases, HDAC, nitric oxide, protein S-nitrosylation, cellular signaling, enzyme modification, chromatin regulation, post-translational modification S-nitrosylated GAPDH, GAPDH, transnitrosylation, histone deacetylases, HDAC, S-nitrosylation, nitric oxide signaling, post-translational modification, GAPDH-HDAC interaction, signal transduction, protein modification
1180	The PRR MDA5 is a sensor of RNA virus infection. PRR, MDA5, sensor, RNA virus, infection, pattern recognition receptor, viral RNA, immune response, innate immunity, viral detection, interferon, antiviral, RIG-I-like receptor, dsRNA, cytoplasmic sensor PRR, MDA5, RNA virus, sensor, RNA virus detection, pattern recognition receptor, innate immunity, viral infection, MDA5 signaling, RIG-I-like receptor, interferon response, viral RNA recognition, host defense PRR, MDA5, RNA virus, infection, sensor, pattern recognition receptor, viral RNA, innate immunity, antiviral response, cytoplasmic sensor, interferon, viral recognition, immune response, pathogen detection, RIG-I-like receptor PRR, MDA5, sensor, RNA virus, infection, innate immunity, viral recognition, pattern recognition receptor, cytoplasmic sensor, antiviral response PRR, MDA5, RNA virus, infection, sensor, pattern recognition receptor, antiviral immunity, innate immune response, viral RNA, pathogen detection
198	CCL19 is absent within dLNs. CCL19, absence, dLNs, draining lymph nodes, chemokine, lymphoid tissue, expression, immune response, lymph node microenvironment, CCL19 deficiency CCL19, absence, draining lymph nodes, dLNs, chemokine, lymphoid tissue, expression, knockout, deficiency, immunology CCL19, absence, dLNs, draining lymph nodes, expression, lymphoid tissues, chemokine, signaling, immune response, localization, immunology, mouse model, tissue specificity CCL19, absence, dLNs, draining lymph nodes, chemokine, expression, lymph node microenvironment, CCL19 deficiency, lymphocyte migration, immune response, node homing, stromal cells, immune signaling, lymphatic tissue, CCL19 knockout CCL19, absence, draining lymph nodes, dLNs, expression, deficiency, chemokine, distribution, localization, lymphoid tissue
870	Obesity decreases life quality. obesity, life quality, quality of life, obesity impact, health outcomes, well-being, obesity consequences, reduced life quality, obesity effects, chronic disease, morbidity, lifestyle, mental health, physical health, life satisfaction obesity, life quality, quality of life, health impact, obesity effects, well-being, physical health, mental health, obesity consequences, reduced quality, lifestyle diseases, chronic illness obesity, life quality, quality of life, health impact, obesity effects, well-being, obesity consequences, health-related quality, obesity outcomes, physical health, mental health, lifestyle diseases obesity, quality of life, life satisfaction, health-related quality, obesity impact, well-being, life expectancy, overweight, physical health, mental health, obesity consequences obesity, life quality, quality of life, health impact, well-being, obesity effects, lifestyle diseases, physical health, mental health, morbidity, chronic disease, obesity consequences, life satisfaction
993	Pyridostatin destabilizes the G - quadruplex in the telomeric region. Pyridostatin, G-quadruplex, telomeric region, G4 destabilization, telomere, quadruplex structure, G-quadruplex inhibitor, DNA secondary structure, small molecules, telomere targeting, quadruplex binding, genomic stability, telomerase, quadruplex unfolding Pyridostatin, G-quadruplex, telomeric region, quadruplex destabilization, telomere, small molecule, DNA secondary structure, quadruplex ligand, telomeric DNA, G4 destabilization, telomere-targeting, DNA-binding compound Pyridostatin, G-quadruplex, telomeric region, destabilization, telomere, quadruplex destabilization, G4 structure, small molecule, DNA secondary structure, telomere targeting, ligand, genome stability, quadruplex binder Pyridostatin, G-quadruplex, telomeric region, destabilization, telomeres, quadruplex DNA, G4 structures, small molecule, DNA secondary structure, telomere targeting, stabilization, genomic instability Pyridostatin, G-quadruplex, telomeric region, destabilization, telomere, G4 ligand, quadruplex structure, DNA secondary structure, small molecule, telomeric DNA, quadruplex destabilization, G-quadruplex stabilization, quadruplex-binding ligand
873	Obesity is determined solely by environmental factors. obesity, environmental factors, determinants, causes, etiology, genetics, lifestyle, diet, physical activity, heredity, multifactorial, risk factors, weight gain, social determinants, biology obesity, environmental factors, causes of obesity, determinants of obesity, obesity etiology, environmental influence, genetic factors, lifestyle factors, obesity risk factors, obesity misconception, obesity causes debate, obesity environment vs genetics obesity, environmental factors, causes, determinants, genetics, biology, lifestyle, diet, physical activity, heredity, multifactorial, risk factors, health, weight gain, misconception obesity, environmental factors, causes, determinants, sole influence, weight gain, lifestyle, nutrition, genetics exclusion, physical activity, environmental impact, obesity causation, risk factors, social determinants, obesity misconceptions obesity, environmental factors, causes, determinants, genetics, lifestyle, diet, physical activity, heredity, biology, socioeconomic status, public health, body mass index, risk factors, environmental influence
1179	The PRR MDA5 has a central DExD/H RNA helices domain. PRR, MDA5, DExD/H, RNA helicase domain, pattern recognition receptor, helicase, innate immunity, central domain, structure, function, protein domains PRR, MDA5, DExD/H domain, RNA helicase, central domain, pattern recognition receptor, MDA5 structure, helicase domain, innate immunity, DExD/H box, RNA sensing, protein domains PRR, MDA5, DExD/H, RNA helicase, domain, central, pattern recognition receptor, structure, function, innate immunity, helicase activity, molecular biology, protein domains PRR, MDA5, DExD/H, RNA helicase domain, central domain, innate immunity, pattern recognition receptor, MDA5 structure, helicase function, antiviral response, RNA sensing PRR, MDA5, DExD/H, RNA helicase domain, central domain, pattern recognition receptor, innate immunity, helicase, structure, molecular biology
1298	Thigh-length graduated compression stockings (GCS) did not reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke. thigh-length graduated compression stockings, GCS, deep vein thrombosis, DVT, acute stroke, immobile patients, hospital, effectiveness, prophylaxis, prevention, randomized controlled trial, clinical outcomes, compression therapy, stroke patients, venous thromboembolism thigh-length compression stockings, graduated compression stockings, deep vein thrombosis, DVT, acute stroke, immobile patients, hospital admission, thromboprophylaxis, effectiveness, clinical outcome, venous thromboembolism, GCS, stroke complications, prevention, randomized controlled trial, negative results thigh-length graduated compression stockings, GCS, deep vein thrombosis, DVT, acute stroke, hospitalized patients, immobility, stroke patients, venous thromboembolism prevention, compression therapy, clinical trial, prophylaxis, negative outcome, vascular complications, randomized controlled trial thigh-length compression stockings, graduated compression stockings, GCS, deep vein thrombosis, DVT, acute stroke, immobile patients, hospitalized stroke patients, prevention, efficacy, clinical outcomes, randomized controlled trial, vascular complications, mechanical prophylaxis, venous thromboembolism thigh-length graduated compression stockings, GCS, deep vein thrombosis, DVT, immobile patients, acute stroke, hospital admission, no reduction, effectiveness, stroke patients, venous thromboembolism prevention, clinical outcomes, compression therapy
513	High cardiopulmonary fitness causes increased mortality rate. cardiopulmonary fitness, high fitness, increased mortality, mortality risk, exercise capacity, cardiorespiratory fitness, fitness level, mortality association, cardiovascular health, risk factors, mortality studies, cardiorespiratory endurance, fitness and mortality, physical fitness, survival rate cardiopulmonary fitness, mortality rate, high fitness, increased mortality, exercise capacity, cardiorespiratory fitness, death risk, physical fitness, mortality association, fitness paradox high cardiopulmonary fitness, increased mortality rate, cardiovascular fitness, mortality risk, physical fitness, mortality, cardiorespiratory fitness, fitness and death rate, exercise capacity, fitness and mortality, health outcomes, physical activity, all-cause mortality, high fitness adverse effects cardiopulmonary fitness, mortality rate, high fitness, exercise, cardiovascular health, mortality risk, physical fitness, death rate, cardiorespiratory fitness, health outcomes, survival, fitness level, all-cause mortality, exercise impact, epidemiology cardiopulmonary fitness, mortality rate, high fitness, exercise, physical fitness, cardiovascular health, respiratory fitness, mortality risk, fitness levels, health outcomes, cause-effect, epidemiology, physical activity, cardiorespiratory fitness, death rate
514	High dietary calcium intakes are unnecessary for prevention of secondary hyperparathyroidism in subjects with 25(OH)D levels above 75 nmol/liter. high dietary calcium, secondary hyperparathyroidism, 25(OH)D, vitamin D status, serum 25-hydroxyvitamin D, calcium intake, parathyroid hormone, prevention, calcium requirements, vitamin D sufficiency, hyperparathyroidism prevention, dietary calcium recommendations high dietary calcium, secondary hyperparathyroidism, 25(OH)D, vitamin D, calcium intake, parathyroid hormone, prevention, serum 25-hydroxyvitamin D, hyperparathyroidism prevention, calcium requirements, vitamin D sufficiency, bone metabolism, calcium homeostasis dietary calcium intake, secondary hyperparathyroidism, 25(OH)D levels, vitamin D, calcium supplementation, parathyroid hormone, bone health, optimal vitamin D, calcium requirements, serum 25-hydroxyvitamin D, hypercalcemia prevention, adult nutrition, osteoporosis, threshold 25(OH)D, bone mineral density dietary calcium, calcium intake, secondary hyperparathyroidism, 25(OH)D, vitamin D, serum 25-hydroxyvitamin D, calcium supplementation, parathyroid hormone, PTH, bone health, high calcium, prevention, threshold 25(OH)D, nmol/L, adult subjects high dietary calcium, calcium intake, secondary hyperparathyroidism, prevention, 25(OH)D, vitamin D, serum 25-hydroxyvitamin D, threshold, calcium requirement, parathyroid hormone, PTH, vitamin D sufficiency, bone health, calcium metabolism, unnecessary supplementation, adults, nutrition
756	Many proteins in human cells can be post-translationally modified at lysine residues via acetylation. proteins, human cells, post-translational modification, lysine residues, acetylation, protein acetylation, lysine acetylation, cellular proteins, histone acetylation, epigenetics, protein function, protein modification proteins, human cells, post-translational modification, lysine residues, acetylation, protein acetylation, lysine acetylation, PTMs, protein modification, histone acetylation, epigenetics, protein regulation proteins, human cells, post-translational modification, lysine residues, acetylation, protein acetylation, lysine acetylation, modification sites, protein modification, epigenetics, histone acetylation, cell biology proteins, human cells, post-translational modification, lysine residues, acetylation, protein acetylation, lysine acetylation, PTMs, histone acetylation, epigenetics, protein regulation, protein function proteins, human cells, post-translational modification, lysine residues, acetylation, protein acetylation, lysine acetylation, protein modification, cellular proteins, epigenetic regulation, histone acetylation, protein function, regulatory modification
636	Inositol lipid 3-phosphatase PTEN converts Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate. PTEN, inositol lipid 3-phosphatase, PtdIns(3,4)P2, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4-phosphate, PI(3,4)P2, PI4P, phosphatase, lipid signaling, dephosphorylation, phosphoinositide metabolism, PTEN function, enzyme activity, signal transduction PTEN, inositol lipid 3-phosphatase, PtdIns(3,4)P2, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4-phosphate, PI(3,4)P2, PI4P, substrate specificity, dephosphorylation, lipid signaling, phosphoinositide metabolism, enzyme activity, signal transduction, lipid phosphatase, cellular signaling PTEN, inositol lipid 3-phosphatase, PtdIns(3,4)P2, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4-phosphate, PI(3,4)P2, PI4P, lipid phosphatase, phosphoinositide metabolism, dephosphorylation, PI3K/AKT pathway, signal transduction, enzyme conversion, lipid signaling, phosphatase activity PTEN, inositol lipid 3-phosphatase, PtdIns(3,4)P2, phosphatidylinositol 4-phosphate, enzymatic conversion, phosphoinositide metabolism, dephosphorylation, lipid signaling, PI3K pathway, phosphatidylinositol phosphatases, PTEN function, lipid second messengers PTEN, inositol lipid 3-phosphatase, PtdIns(3,4)P2, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4-phosphate, PI(3,4)P2, PI4P, lipid signaling, dephosphorylation, lipid phosphatase, phosphoinositide metabolism
516	High levels of CRP reduces the risk of exacerbations in chronic obstructive pulmonary disease (COPD). CRP, C-reactive protein, reduced risk, exacerbations, chronic obstructive pulmonary disease, COPD, inflammation, biomarker, protective effect, respiratory disease, flare-ups, risk factors, severity, outcomes, acute exacerbation CRP, C-reactive protein, high CRP, COPD, chronic obstructive pulmonary disease, exacerbation risk, inflammation, COPD exacerbations, biomarker, risk reduction, pulmonary disease, respiratory inflammation CRP, C-reactive protein, chronic obstructive pulmonary disease, COPD, exacerbations, inflammation, risk reduction, biomarkers, COPD outcomes, respiratory disease, acute exacerbations, COPD progression, inflammatory markers, disease severity CRP, C-reactive protein, high levels, risk reduction, exacerbations, chronic obstructive pulmonary disease, COPD, inflammation, biomarkers, respiratory disease, COPD management, exacerbation prevention, pulmonary function, chronic disease, clinical outcomes CRP, C-reactive protein, high CRP, COPD, chronic obstructive pulmonary disease, exacerbation risk, exacerbations, inflammation, biomarkers, risk reduction, disease progression, chronic lung disease
637	Input from  mental and physical health care professionals is effective at decreasing homelessness. mental health professionals, physical health care professionals, homelessness reduction, homelessness intervention, multidisciplinary care, healthcare input, effectiveness, integrated care, support services, homeless population, coordinated care, service outcomes, collaboration, healthcare impact, housing stability mental health professionals, physical health professionals, homelessness, intervention effectiveness, healthcare input, reducing homelessness, multidisciplinary care, integrated care, support services, homelessness prevention, healthcare impact, mental health services, physical health services, collaborative care, health interventions, homelessness outcomes mental health care, physical health care, professionals, homelessness, input, effectiveness, intervention, support services, homeless population, health interventions, reduction, multidisciplinary approach, healthcare impact mental health professionals, physical health professionals, effectiveness, reducing homelessness, homelessness intervention, healthcare input, homeless population, multidisciplinary care, support services, integrated care, health and homelessness, outreach programs, service delivery, health outcomes, interprofessional collaboration mental health professionals, physical health professionals, homelessness, intervention effectiveness, healthcare input, reducing homelessness, multidisciplinary approach, health care services, homelessness prevention, professional involvement, supportive services, homeless population, integrated care, outcomes, healthcare collaboration
879	Occupancy of ribosomes by IncRNAs do not make functional peptides. ribosome occupancy, IncRNAs, noncoding RNA, functional peptides, translation, peptide synthesis, ribosome profiling, long noncoding RNAs, protein coding potential, RNA translation, non-functional peptides, ribosomal binding, lncRNA translation ribosome occupancy, IncRNAs, long noncoding RNAs, translation, functional peptides, noncoding RNA translation, ribosome profiling, peptide production, IncRNA ribosome association, noncoding RNA function ribosome occupancy, IncRNAs, noncoding RNAs, ribosome profiling, peptide synthesis, functional peptides, translation, lncRNA translation, non-functional peptides, translational regulation, ribosome association, noncoding transcript, ribosome-bound lncRNAs ribosome occupancy, IncRNAs, functional peptides, noncoding RNA translation, ribosome profiling, lncRNA peptide production, translational efficiency, noncoding RNA function, peptide synthesis, ribosome association, IncRNA translation, noncoding transcriptome ribosome occupancy, IncRNAs, lncRNAs, noncoding RNAs, functional peptides, translation, peptide synthesis, ribosome profiling, noncoding RNA translation, lncRNA ribosome association, peptide production, functional genomics
517	High levels of copeptin decrease risk of diabetes. copeptin, high copeptin, diabetes risk, diabetes prevention, copeptin levels, type 2 diabetes, diabetes biomarkers, protective factors, hormonal biomarkers, metabolic disease, diabetes susceptibility, diabetes incidence copeptin, high levels, diabetes risk, biomarker, type 2 diabetes, diabetes prevention, endocrine markers, metabolic risk, diabetes prediction, antidiuretic hormone, vasopressin, glucose metabolism, insulin resistance, risk factors copeptin, high levels, diabetes risk, biomarker, diabetes prevention, endocrine markers, vasopressin surrogate, metabolic syndrome, insulin resistance, glucose metabolism, predictive marker, type 2 diabetes, risk reduction copeptin, diabetes risk, high copeptin levels, diabetes prevention, copeptin biomarkers, diabetes incidence, metabolic health, endocrine markers, diabetes epidemiology, copeptin association, diabetes susceptibility, hormone levels, diabetes protection copeptin, high levels, diabetes risk, decreased risk, diabetes prevention, biomarker, metabolic syndrome, insulin resistance, endocrinology, type 2 diabetes, vasopressin, predictive marker, glucose metabolism
759	Mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs have a dramatic impact in reducing malaria transmission. mathematical models, artemisinin-based combination therapy, ACT, nongametocytocidal drugs, malaria transmission, impact, reduction, predictive modeling, malaria control, drug efficacy, transmission dynamics, combination therapy, gametocytes, antimalarial treatment, public health, infectious disease modeling Mathematical models, Artemisinin-based combination therapy, ACT, nongametocytocidal drugs, malaria transmission, malaria reduction, drug efficacy, gametocytocidal activity, malaria control, mathematical prediction, infectious disease modeling, malaria treatment, drug impact, malaria elimination, combination therapy Artemisinin-based combination therapy, ACT, nongametocytocidal drugs, malaria transmission, mathematical models, malaria reduction, antimalarial drugs, gametocytocidal activity, malaria control, malaria prediction, infectious disease modeling, drug efficacy, transmission dynamics mathematical models, Artemisinin-based combination therapy, ACT, nongametocytocidal drugs, malaria transmission, malaria control, predictive modeling, malaria treatment, impact reduction, malaria epidemiology mathematical models, Artemisinin-based combination therapy, ACT, nongametocytocidal drugs, malaria transmission, malaria reduction, predictive modeling, malaria control, drug efficacy, gametocytocidal drugs, malaria prevention, infectious disease modeling, transmission dynamics, combination therapy malarial, malaria intervention
94	Albendazole is used to treat lymphatic filariasis. Albendazole, lymphatic filariasis, treatment, antiparasitic, filarial infection, deworming, anthelmintic, parasite control, filariasis therapy, helminth infection, neglected tropical diseases Albendazole, lymphatic filariasis, treatment, antiparasitic, filarial infection, antihelminthic, parasitic disease, therapy, Wuchereria bancrofti, Brugia malayi, medication, use, efficacy Albendazole, lymphatic filariasis, treatment, anti-parasitic, filarial infection, albendazole therapy, filariasis management, antiparasitic drug, microfilariae, deworming, neglected tropical diseases, helminth infection, Wuchereria bancrofti, Brugia malayi, tropical medicine Albendazole, lymphatic filariasis, treatment, antiparasitic, helminth infection, filarial worms, disease management, therapy, medication, parasitic disease, WHO, drug regimen, filariasis control, microfilariae, nematode infection Albendazole, lymphatic filariasis, antiparasitic, filarial infection, treatment, antihelminthic, Wuchereria bancrofti, Brugia malayi, tropical diseases, parasitic worms, drug therapy, neglected tropical diseases, helminthiasis, filariasis management, medication
99	Alizarin forms hydrogen bonds with residues involved in PGAM1 substrate binding. Alizarin, hydrogen bonding, PGAM1, substrate binding, protein-ligand interactions, binding residues, enzyme inhibition, molecular docking, active site, biochemical interactions Alizarin, hydrogen bonds, PGAM1, substrate binding, protein-ligand interactions, binding residues, molecular docking, enzyme inhibition, binding site, residue interactions, structure-function, active site, phosphoglycerate mutase, hydrogen bonding, small molecule-protein Alizarin, hydrogen bonds, PGAM1, substrate binding, residues, interaction, protein-ligand binding, enzyme active site, molecular docking, binding affinity, hydrogen bonding, PGAM1 inhibition, protein structure, ligand interactions Alizarin, hydrogen bonds, PGAM1, substrate binding, residues, protein-ligand interaction, binding site, molecular docking, interactions, active site, structure-function, enzyme inhibition, computational chemistry Alizarin, hydrogen bonds, PGAM1, substrate binding, protein-ligand interaction, binding residues, molecular docking, active site, hydrogen bonding, enzyme inhibition, ligand binding, structure-function, bioinformatics, pharmacology
1197	The availability of safe places to study is not effective at decreasing homelessness. safe study spaces, homelessness, effectiveness, reducing homelessness, student homelessness, impact, availability, shelter, academic environment, homeless students, prevention, safe environments, educational spaces, housing insecurity safe study spaces, homelessness, effectiveness, reducing homelessness, study environments, homeless population, impact of study spaces, shelter alternatives, student homelessness, safe environments, homelessness solutions, educational spaces, safe places, homelessness prevention safe study spaces, effectiveness, reducing homelessness, homelessness prevention, study space impact, homeless youth, educational resources, safe environments, homelessness solutions, shelter access, academic support, student homelessness safe study spaces, homelessness, homelessness prevention, effectiveness, shelter access, housing insecurity, public spaces, student homelessness, study areas, safety, housing solutions safe study spaces, homelessness, effectiveness, availability, impact, study environments, housing insecurity, homeless prevention, academic spaces, student homelessness, public spaces, safety, shelter alternatives, education and homelessness, intervention effectiveness
1196	The availability of safe places to study is effective at decreasing homelessness. safe study spaces, homelessness reduction, study environment, homeless prevention, safe learning areas, effective interventions, academic spaces, at-risk youth, educational resources, shelter alternatives, student homelessness, supportive environments safe study spaces, homelessness reduction, effect of study spaces, access to study areas, educational environment, impact on homelessness, student homelessness, safe learning environments, study area availability, homelessness prevention, academic resources, secure study locations safe study spaces, homelessness prevention, impact of study spaces, safe learning environments, reducing homelessness, educational access, youth homelessness, community resources, safe environments for students, student homelessness, homelessness interventions, academic support services, safe sites for study safe study spaces, homelessness reduction, educational environments, homeless prevention, safe learning areas, student homelessness, effective interventions, academic facilities, shelter alternatives, safe public spaces, youth homelessness, study space accessibility, homelessness solutions safe study spaces, homelessness reduction, effective interventions, shelter availability, student support, educational environments, homelessness prevention, safe learning environments, housing insecurity, supportive services, access to study areas, educational support, youth homelessness
1194	The arm density of TatAd complexes is due to structural rearrangements within Class1 TatAd complexes such as the 'charge zipper mechanism'. TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein structure, protein complex assembly, Tat pathway, mechanistic basis, molecular interactions, translocation system, membrane proteins, charge interactions, protein conformation, cryo-EM analysis, oligomerization TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein structure, protein complexes, molecular mechanism, structural biology, protein assembly TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein structure, Tat pathway, complex assembly, protein-protein interactions, membrane protein, electron microscopy, oligomerization, conformational change TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein structure, molecular mechanism, protein complexes, conformational changes, electron density, protein machinery, translocation system TatAd complexes, arm density, structural rearrangements, Class1 TatAd, charge zipper mechanism, protein structure, complex formation, structural biology, protein-protein interactions, charge interactions, conformational changes
1191	The amount of publicly available DNA data doubles every 10 years. public DNA data, DNA database growth, DNA data increase rate, DNA data availability, genomic data doubling, DNA data expansion, genetic data trends, publicly accessible DNA, genomics data statistics, genetic information growth publicly available DNA data, DNA data growth rate, DNA data doubling time, genetic data expansion, genomics data trends, DNA database increase, genetic information availability, DNA sequencing data, genomic databases, DNA data statistics public DNA databases, DNA data growth rate, genomic data increase, publicly available genomics, DNA sequence repositories, genomic data doubling, DNA data statistics, genomics data expansion, biological data trends, DNA information public access publicly available DNA data, DNA data growth rate, DNA database expansion, DNA data doubling time, genomic data increase, DNA information statistics, genomics data trends, DNA database size, DNA sequencing data, DNA data storage, DNA data accessibility, genomic data repository publicly available DNA data, DNA data growth rate, DNA database expansion, DNA data doubling time, genetic data availability, DNA sequence repositories, genomics data increase, DNA data statistics, longitudinal DNA data growth, genetic information trends
880	Occupancy of ribosomes by IncRNAs mirror 5 0-UTRs ribosome occupancy, IncRNAs, 5' UTR, untranslated regions, ribosome profiling, non-coding RNAs, translation regulation, mRNA structure, IncRNA-ribosome association, ribosome binding, transcriptome analysis, UTR function, IncRNA translation, RNA-ribosome interaction, post-transcriptional regulation ribosome occupancy, IncRNAs, 5' UTRs, ribosome profiling, translational regulation, lncRNA translation, non-coding RNA, untranslated regions, mRNA translation, gene expression ribosome occupancy, IncRNAs, 5' UTRs, ribosome profiling, noncoding RNA translation, untranslated regions, RNA-ribosome interaction, translational regulation, IncRNA ribosome binding, mRNA translation, transcriptome analysis, ribosome association, IncRNA function ribosome occupancy, IncRNAs, 5' UTRs, translation regulation, noncoding RNA, ribosome profiling, untranslated regions, IncRNA translation, gene expression, RNA-ribosome interaction ribosome occupancy, IncRNAs, 5' UTRs, ribosome profiling, noncoding RNAs, translation regulation, transcriptome, untranslated region, lncRNA ribosome binding, RNA sequencing, translational control, IncRNA translation
882	Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians. omnivores, vegetarians, trimethylamine N-oxide, TMAO, dietary L-carnitine, metabolism, gut microbiota, carnitine metabolism, differences, comparison, diet, microbiome, nutrient conversion, L-carnitine intake, TMAO production omnivores, trimethylamine N-oxide, TMAO, dietary L-carnitine, vegetarians, metabolism, gut microbiota, microbiome, nutrient conversion, diet comparison, cardiovascular risk omnivores, vegetarians, trimethylamine N-oxide, TMAO, dietary L-carnitine, metabolism, gut microbiota, nutrient conversion, carnivorous diet, comparative analysis, choline metabolism, cardiovascular risk, human diet, microbiome differences omnivores, trimethylamine N-oxide, TMAO, dietary L-carnitine, vegetarians, gut microbiota, metabolism, carnitine metabolism, intestinal bacteria, nutrient processing, omnivore vs vegetarian, cardiovascular risk, diet comparison omnivores, vegetarians, trimethylamine N-oxide, TMAO, dietary L-carnitine, metabolism, gut microbiota, meat consumption, plant-based diet, differential production, cardiovascular risk
641	Insomnia can be effectively treated with cognitive behavioral therapy. insomnia, cognitive behavioral therapy, CBT, insomnia treatment, sleep disorders, behavioral therapy for sleep, non-pharmacological interventions, sleep therapy, psychological treatment, CBT for insomnia insomnia, cognitive behavioral therapy, CBT, insomnia treatment, sleep disorders, behavioral therapy, non-pharmacological insomnia treatment, cognitive therapy for insomnia, sleep therapy, psychological interventions, evidence-based insomnia treatment insomnia, cognitive behavioral therapy, CBT, insomnia treatment, behavioral sleep therapy, non-pharmacological intervention, sleep disorders, sleep therapy, psychological treatment, sleep improvement insomnia, cognitive behavioral therapy, CBT, insomnia treatment, sleep disorders, behavioral interventions, non-pharmacological therapy, sleep therapy, mental health, evidence-based treatment insomnia, cognitive behavioral therapy, CBT, insomnia treatment, sleep disorder, behavioral therapy, non-pharmacological treatment, sleep therapy, insomnia management, evidence-based therapy
521	High-sensitivity cardiac troponin T (HSCT-T) dosage may not be diagnostic if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI). high-sensitivity cardiac troponin T, HSCT-T, dosage, diagnostic limitations, symptom onset, less than 3 hours, acute myocardial injury, AMI, early detection, biomarker sensitivity, cardiac biomarkers, myocardial infarction, diagnostic accuracy, time window, troponin testing high-sensitivity cardiac troponin T, hs-cTnT, dosage, early symptom onset, less than 3 hours, acute myocardial injury, AMI, cardiac biomarkers, diagnostic accuracy, sensitivity, troponin window period, early detection, myocardial infarction, biomarker timing, chest pain onset High-sensitivity cardiac troponin T, HSCT-T, troponin T, early onset, symptom onset, less than 3 hours, acute myocardial injury, AMI, diagnostic accuracy, early diagnosis, cardiac biomarkers, sensitivity, specificity, myocardial infarction, timing, rapid diagnosis high-sensitivity cardiac troponin T, HSCT-T, early symptom onset, acute myocardial injury, AMI, diagnosis, biomarker timing, less than 3 hours, cardiac biomarkers, sensitivity, specificity, early detection, troponin release kinetics, diagnostic accuracy, myocardial infarction high-sensitivity cardiac troponin T, HSCT-T, troponin assay timing, early symptom onset, acute myocardial injury, AMI, diagnostic accuracy, biomarker kinetics, early detection, chest pain duration, myocardial infarction, rule-out strategies, cardiac biomarkers, sensitivity, specificity
644	Insulin increases risk of severe kidney failure. insulin, kidney failure, severe kidney disease, insulin risk, diabetic nephropathy, end-stage renal disease, insulin complications, renal failure, diabetes, insulin therapy, kidney damage, adverse effects, insulin and kidneys Insulin, risk, severe kidney failure, diabetic nephropathy, renal failure, insulin therapy, end-stage renal disease, chronic kidney disease, insulin side effects, diabetes complications, nephrotoxicity, kidney damage insulin, risk, severe kidney failure, diabetic nephropathy, end-stage renal disease, renal failure, insulin therapy, chronic kidney disease, adverse effects, diabetes complications insulin, kidney failure, severe, risk, diabetic nephropathy, end-stage renal disease, ESRD, insulin therapy, renal complications, diabetes, adverse effects, progression, chronic kidney disease, CKD insulin, risk, severe kidney failure, diabetic nephropathy, end-stage renal disease, insulin therapy, chronic kidney disease, renal complications, diabetes, nephrotoxicity
887	Only a minority of cells survive development after differentiation into stress-resistant spores. cell survival, developmental biology, differentiation, stress-resistant spores, minority cells, sporulation, cell fate, survival rate, developmental process, cellular differentiation, spore formation, stress resistance, cell population, spore survivability cell survival, development, differentiation, stress-resistant spores, minority of cells, spore formation, cellular differentiation, stress resistance, cell fate, developmental biology minority, cell survival, development, differentiation, stress-resistant spores, sporulation, cell fate, cell viability, developmental biology, spore formation, survival rate, differentiation outcome, stress tolerance cell survival, development, differentiation, stress-resistant spores, minority, cell fate, sporulation, cellular differentiation, developmental biology, survival rate, stress resistance minority, cells, survive, development, differentiation, stress-resistant, spores, cell survival, sporulation, developmental biology, cellular differentiation, spore resistance, cell fate, cell death, stress tolerance
525	Histone demethylase recruitment and a transient decrease in histone methylation is necessary for ligand-dependent induction of transcription by nuclear receptors. histone demethylase, recruitment, transient decrease, histone methylation, ligand-dependent, transcription induction, nuclear receptors, chromatin remodeling, gene expression, epigenetic regulation histone demethylase recruitment, histone methylation decrease, ligand-dependent induction, transcription activation, nuclear receptors, chromatin remodeling, epigenetic regulation, gene expression, histone modification, coregulator proteins, transcriptional activation, methylation dynamics histone demethylase recruitment, transient histone methylation decrease, ligand-dependent transcription, nuclear receptors, transcription induction, chromatin modification, gene regulation, epigenetic regulation, histone modification, coactivator recruitment histone demethylase, recruitment, histone methylation, transient decrease, ligand-dependent induction, transcription, nuclear receptors, epigenetic regulation, chromatin remodeling, gene expression, coregulators, transcriptional activation, histone modifications histone demethylase, recruitment, histone methylation, transient decrease, ligand-dependent, transcription induction, nuclear receptors, epigenetic regulation, chromatin remodeling, gene expression, coactivators, histone modifications
768	Mercaptopurine is anabolized into the inactive methylmercaptopurine by thiopurine methyltrasnferase (TPMT). mercaptopurine, anabolism, inactive metabolite, methylmercaptopurine, thiopurine methyltransferase, TPMT, drug metabolism, thiopurines, pharmacogenetics, enzyme activity, methylation, inactivation, TPMT polymorphism, immunosuppressant, leukemia treatment mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine methyltransferase, TPMT, drug metabolism, thiopurine, methylation, enzyme, pharmacogenetics, metabolite, inactivation mercaptopurine, anabolism, methylmercaptopurine, thiopurine methyltransferase, TPMT, inactive metabolite, thiopurine metabolism, drug metabolism, methylation, pharmacogenetics, enzyme activity, TPMT polymorphism, immunosuppressant, inactivation pathway Mercaptopurine, anabolized, inactive, methylmercaptopurine, thiopurine methyltransferase, TPMT, metabolic pathway, drug metabolism, enzyme, thiopurine, methylation mercaptopurine, anabolism, inactive metabolite, methylmercaptopurine, thiopurine methyltransferase, TPMT, drug metabolism, enzyme activity, pharmacogenomics, thiopurines, methylation, metabolite formation
527	Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevents oxidative stress. homozygous deletion, Sbds gene, murine, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress prevention, mouse model, gene knockout, skeletal development, osteogenesis, oxidative stress, bone biology homozygous deletion, Sbds gene, murine, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, bone development, gene knockout, antioxidant response, osteogenesis, mouse model, redox homeostasis, Osx-positive cells Sbds gene, homozygous deletion, osterix-expressing, mesenchymal stem cells, progenitor cells, murine, oxidative stress, gene knockout, mouse model, osteogenesis, conditional deletion, antioxidant response, Osx-Cre, stem cell differentiation Homozygous deletion, murine, Sbds gene, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, mouse model, bone development, genetic knockout, antioxidant response, skeletal system, osteogenesis, redox homeostasis homozygous deletion, Sbds gene, murine, osterix-expressing, mesenchymal stem cells, progenitor cells, MPCs, oxidative stress, gene knockout, mouse model, bone biology, antioxidant response, genetic modification, osteogenesis, stem cell differentiation
528	Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) patients produce Immunoglobulin G (IgG) antibodies which cross-react with an immunodominant epitope in Tax. Human T-lymphotropic virus type I, HTLV-I, HAM/TSP, myelopathy, tropical spastic paraparesis, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, antibody response, neuroinflammatory disease, autoimmunity, serology, viral antigens Human T-lymphotropic virus type I, HAM/TSP, tropical spastic paraparesis, myelopathy, Immunoglobulin G, IgG antibodies, cross-reactivity, Tax protein, immunodominant epitope, antibody response, HTLV-I, neurological disorders, autoimmunity, viral antigens, immune response Human T-lymphotropic virus type I, HTLV-I, myelopathy, tropical spastic paraparesis, HAM/TSP, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, autoimmune response, serological markers, virology, neuroinflammation, antibody response Human T-lymphotropic virus type-I, HTLV-I, HTLV-1, associated myelopathy, tropical spastic paraparesis, HAM/TSP, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, antibody response, neurological disorders, retrovirus, autoimmune response, epitopes, immune response, viral antigens, serology, Tax-specific antibodies, HTLV-I seropositivity Human T-lymphotropic virus type I, HTLV-I, associated myelopathy, tropical spastic paraparesis, HAM/TSP, Immunoglobulin G, IgG antibodies, cross-reactivity, immunodominant epitope, Tax protein, antibody response, neuroinflammatory disorders, viral antigen, immune response, neurological complications, autoimmunity
649	Integrating classroom-based collaborative learning with Web-based collaborative learning leads to subpar class performance classroom-based collaborative learning, Web-based collaborative learning, integration, class performance, student performance, blended learning, collaborative learning outcomes, hybrid learning, academic achievement, learning effectiveness, collaboration methods, educational technology, learning integration, online learning, face-to-face learning, learning environments, teaching strategies, instructional design, group work, digital collaboration classroom-based collaborative learning, web-based collaborative learning, integration, subpar class performance, academic outcomes, blended learning, student achievement, collaborative learning effectiveness, educational technology, learning integration challenges classroom-based collaborative learning, web-based collaborative learning, integration impact, class performance, academic outcomes, blended learning, educational technology, student collaboration, learning effectiveness, instructional methods, online collaboration, face-to-face collaboration, learning integration challenges classroom-based collaborative learning, web-based collaborative learning, integration, class performance, academic outcomes, blended learning, online collaboration, in-person collaboration, educational technology, student achievement, hybrid learning, learning effectiveness, collaborative education, teaching strategies, learning environments classroom-based collaborative learning, web-based collaborative learning, integration, academic performance, subpar results, blended learning, collaborative education, classroom integration, online collaboration, student outcomes, educational technology, learning effectiveness, performance impact, blended instruction, digital collaboration
1088	Silencing of Bcl2 is important for the maintenance and progression of tumors. Bcl2 silencing, tumor maintenance, tumor progression, cancer, gene silencing, apoptosis, oncogenesis, tumor biology, Bcl2 expression, cancer progression Bcl2, silencing, tumor maintenance, tumor progression, gene expression, cancer, oncogenesis, apoptosis, tumor biology, molecular mechanisms Bcl2, silencing, tumor maintenance, tumor progression, gene expression, cancer, apoptosis, oncogenesis, tumor biology, Bcl2 inhibition Bcl2, silencing, tumor maintenance, tumor progression, cancer, gene expression, apoptosis, oncogenesis, tumorigenesis, cancer development, Bcl2 inhibition Bcl2, silencing, tumor maintenance, tumor progression, cancer, gene regulation, apoptosis, oncogenesis, tumor biology, cell survival
1086	Sildenafil improves erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants. Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, treatment, men, selective serotonin reuptake inhibitors, drug-induced sexual dysfunction, phosphodiesterase type 5 inhibitors, medication side effects, male sexual health, antidepressant-induced sexual dysfunction Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, treatment, men, selective serotonin reuptake inhibitors, SSRI-induced sexual dysfunction, phosphodiesterase inhibitors, erectile dysfunction, drug interaction, sexual side effects, male sexual health, antidepressant-induced dysfunction Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, SSRI-induced sexual dysfunction, phosphodiesterase inhibitors, male sexual health, selective serotonin reuptake inhibitors, erectile dysfunction treatment, pharmacological intervention, antidepressant side effects, male patients, sexual side effects, medication-induced dysfunction Sildenafil, erectile function, sexual dysfunction, SSRI antidepressants, selective serotonin reuptake inhibitors, antidepressant-induced sexual dysfunction, male sexual health, erectile dysfunction treatment, phosphodiesterase-5 inhibitors, SSRI side effects, Sildenafil efficacy, drug-induced sexual dysfunction, male impotence, psychotropic medication side effects, sexual function improvement Sildenafil, erectile function, sexual dysfunction, SSRI, antidepressants, treatment, male, selective serotonin reuptake inhibitors, drug-induced sexual dysfunction, therapy, sexual side effects, pharmacological intervention, impotence, SSRIs, male sexual health
770	Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in reduced efficacy and lower quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients, treatment comparison, chemotherapy regimens, clinical outcomes, geriatric oncology metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients, comparison, treatment outcomes, chemotherapy regimens, older adults, cancer therapy, clinical effectiveness, quality of life measurements metastatic colorectal cancer, single agent fluoropyrimidines, oxaliplatin-based chemotherapy, reduced efficacy, lower quality of life, elderly patients, treatment comparison, advanced colorectal cancer, chemotherapy regimens, fluoropyrimidines monotherapy, older adults, cancer outcomes, efficacy comparison, quality of life assessment metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, lower quality of life, oxaliplatin-based chemotherapy, elderly patients, treatment comparison, chemotherapy outcomes, geriatric oncology, colorectal cancer therapy metastatic colorectal cancer, single agent fluoropyrimidines, reduced efficacy, quality of life, oxaliplatin-based chemotherapy, elderly patients, chemotherapy comparison, treatment outcomes, advanced colorectal cancer, fluoropyrimidine monotherapy
410	Febrile seizures increase the threshold for development of epilepsy. febrile seizures, epilepsy risk, seizure threshold, epilepsy development, febrile convulsions, seizure susceptibility, pediatric epilepsy, neurological risk factors, childhood seizures, seizure disorders febrile seizures, epilepsy, seizure threshold, risk factors, epileptogenesis, childhood seizures, recurrent seizures, neurological development, seizure susceptibility, long-term outcomes febrile seizures, epilepsy risk, seizure threshold, epilepsy development, febrile convulsions, epilepsy susceptibility, seizure predisposition, pediatric epilepsy, risk factors, febrile seizure outcomes febrile seizures, epilepsy risk, seizure threshold, epilepsy development, fever-induced seizures, epileptogenesis, seizure susceptibility, risk factors, childhood seizures, neurological outcomes febrile seizures, epilepsy, seizure threshold, risk factors, epilepsy development, childhood seizures, febrile convulsions, neurological disorders, seizure predisposition, epileptogenesis, pediatric neurology, seizure susceptibility, fever-induced seizures
411	Febrile seizures reduce the threshold for development of epilepsy. febrile seizures, epilepsy, seizure threshold, risk factors, epilepsy development, children, neurological disorders, fever-induced seizures, epileptogenesis, seizure susceptibility febrile seizures, epilepsy, seizure threshold, epilepsy risk, fever-induced seizures, pediatric neurology, seizure susceptibility, epileptogenesis, neurological disorders, risk factors, childhood seizures, epilepsy development febrile seizures, epilepsy, seizure threshold, risk factors, development, pediatric neurology, seizure susceptibility, epilepsy onset, neurological disorders, fever-induced seizures febrile seizures, epilepsy, seizure threshold, risk factors, development, predisposition, neurological disorders, pediatric, incidence, epilepsy onset, febrile convulsions, epilepsy susceptibility febrile seizures, epilepsy, seizure threshold, risk factors, epilepsy development, recurrent seizures, childhood epilepsy, seizure susceptibility, neurologic outcomes, epileptogenesis
532	Hyperfibrinogenemia decreases rates of femoropopliteal bypass thrombosis. hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft patency, fibrinogen levels, vascular surgery, thrombotic risk, graft occlusion, lower limb bypass, arterial bypass, postoperative outcomes, clot formation, vascular graft, thrombosis prevention hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft patency, fibrinogen levels, vascular surgery, thrombotic risk, arterial bypass, graft occlusion, postoperative outcomes hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft patency, arterial bypass, coagulation, fibrinogen levels, vascular surgery, graft thrombosis, lower limb ischemia, thromboprophylaxis, hemostasis, peripheral arterial disease hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft, graft patency, vascular surgery, fibrinogen, blood clot, limb ischemia, thrombotic risk, surgical outcomes, lower limb revascularization, arterial bypass, coagulation, vascular graft failure hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft patency, fibrinogen levels, vascular surgery, thrombotic risk, arterial bypass, clot formation, graft occlusion
533	Hyperfibrinogenemia increases rates of femoropopliteal bypass thrombosis. hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft occlusion, fibrinogen levels, vascular surgery, graft thrombosis, postoperative complications, risk factors, arterial bypass, lower limb ischemia, coagulation disorders hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft failure, vascular surgery, graft occlusion, coagulation, risk factors, fibrinogen, lower limb ischemia, arterial bypass, postoperative complications hyperfibrinogenemia, femoropopliteal bypass, thrombosis, graft occlusion, fibrinogen levels, vascular surgery, risk factors, bypass graft failure, thrombotic complications, lower limb ischemia hyperfibrinogenemia, femoropopliteal bypass, thrombosis, vascular surgery, graft occlusion, risk factors, arterial bypass, coagulation, postoperative complications, fibrinogen levels hyperfibrinogenemia, femoropopliteal bypass, thrombosis, bypass graft failure, vascular surgery, graft occlusion, risk factors, fibrinogen, arterial thrombosis, lower limb bypass, postoperative complications
775	Mice defective for deoxyribonucleic acid (DNA) polymerase I (polI) reveal increased sensitivity to ionizing radiation (IR). mice, DNA polymerase I, polI, gene knockout, ionizing radiation, IR, sensitivity, DNA damage, mouse model, radiation response, DNA repair, genetic deficiency, mutagenesis, radiosensitivity, molecular genetics mice, DNA polymerase I, polI, DNA repair, gene knockout, ionizing radiation, IR sensitivity, radiation sensitivity, mutant mice, DNA damage, radioresistance, DNA polymerase deficiency, DNA repair defect, radiation response, murine models DNA polymerase I, polI, mouse model, gene knockout, ionizing radiation, IR, radiosensitivity, DNA repair, genetic deficiency, radiobiology, DNA damage, murine, radiation response, genome stability mice, DNA polymerase I, polI, gene knockout, radiation sensitivity, ionizing radiation, DNA repair, mouse model, radiobiology, DNA damage, genetic deficiency mice, DNA polymerase I, polI deficiency, ionizing radiation, IR sensitivity, DNA repair, radiation sensitivity, genetic defects, mouse model, DNA damage, polymerase mutant, DNA integrity, radiation response
1199	The benefits of colchicine were achieved with effective widespread use of secondary prevention strategies such as high-dose statins. colchicine, benefits, secondary prevention, high-dose statins, statin therapy, cardiovascular disease, lipid-lowering, widespread use, prevention strategies, treatment outcomes, heart disease, anti-inflammatory therapy, cholesterol management colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, effectiveness, widespread use, lipid-lowering therapy, atherosclerosis prevention, anti-inflammatory therapy, statin therapy, clinical outcomes colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, statin therapy, prevention strategies, widespread use, cholesterol management, heart disease, lipid lowering, inflammation, atherosclerosis colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, widespread use, therapy, efficacy, lipid-lowering agents, outcomes, adjunct treatment colchicine, benefits, secondary prevention, high-dose statins, cardiovascular disease, statin therapy, widespread use, clinical outcomes, anti-inflammatory therapy, lipid-lowering agents
535	Hypertension is frequently observed in type 1 diabetes patients. Hypertension, type 1 diabetes, diabetes mellitus, comorbidity, high blood pressure, diabetic complications, prevalence, risk factors, cardiovascular disease, metabolic disorders, blood pressure management, diabetes-associated hypertension hypertension, type 1 diabetes, diabetes mellitus type 1, high blood pressure, diabetic complications, hypertension prevalence, type 1 diabetic patients, comorbidities, cardiovascular risk, diabetes-associated hypertension hypertension, type 1 diabetes, diabetes mellitus type 1, high blood pressure, prevalence, co-morbidity, diabetic complications, risk factors, epidemiology, glucose control, insulin, cardiovascular risk hypertension, type 1 diabetes, diabetes mellitus, high blood pressure, diabetic complications, comorbidities, cardiovascular risk, glucose control, insulin-dependent diabetes, diabetes management, blood pressure, T1D, chronic disease, epidemiology hypertension, type 1 diabetes, diabetes mellitus type 1, high blood pressure, diabetes complications, comorbidity, prevalence, diabetic patients, cardiovascular risk, chronic complications, co-occurrence
415	Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for dementia. female, carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia, Alzheimer's disease, genetic risk, women, cognitive decline, neurodegeneration, susceptibility, late-onset Alzheimer's, sex differences female carriers, Apolipoprotein E4, APOE4, allele, dementia risk, genetic risk factors, Alzheimer's disease, sex differences, women, neurodegenerative diseases female carriers, Apolipoprotein E4, APOE4, allele, increased risk, dementia, genetic risk, Alzheimer's disease, women, neurodegenerative disorders female carriers, APOE4, Apolipoprotein E4, allele, dementia, increased risk, Alzheimer's disease, genetic risk, women, neurodegenerative disease, cognitive decline, gene variant, sex differences, risk factors, genotype female carriers, Apolipoprotein E4, APOE4, dementia risk, genetic risk, Alzheimer's disease, women, neurodegeneration, susceptibility, allele, cognitive decline
536	Hypocretin neurones induce panicprone state in rats. hypocretin, neurons, panic, panic-prone, state, rats, orexin, anxiety, rodent, neuroscience, behavior, stress, neurobiology, animal model, neuropeptides hypocretin, orexin, neurons, panic-prone, panic, state, induction, rats, animal model, anxiety, neurobiology, behavior, neuroscience, stress response, panic disorder hypocretin, orexin, neurons, neurones, panic-prone, panic state, rats, rodent model, anxiety, neurobiology, panic disorder, hypothalamus, behavior, neuroscience, stress response, animal study hypocretin, orexin, neurones, neurons, panic-prone, panic state, panic disorder, rats, rodent model, anxiety, neurobiology, neural circuits, emotional behavior, stress response, animal study hypocretin, orexin, neurones, neurons, panic-prone, panic, anxiety, rats, rodent model, neural mechanisms, stress response, brain pathways, arousal, emotion regulation, experimental study, neuroscience, behavioral neuroscience, neurobiology
659	Ivermectin is used to treat lymphatic filariasis. Ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial infection, therapy, parasitic diseases, medicine, drug, disease control, helminthiasis, nematodes, tropical diseases, public health, onchocerciasis, mass drug administration ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial infection, microfilariae, river blindness, onchocerciasis, parasitic diseases, antiparasitic therapy, nematode infection, filariasis management ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial infection, helminthiasis, ivermectin therapy, Wuchereria bancrofti, Brugia malayi, parasite control ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial infection, therapeutic use, helminthiasis, microfilariae, Wuchereria bancrofti, Brugia malayi, parasite control, tropical diseases, neglected tropical diseases, drug therapy Ivermectin, lymphatic filariasis, treatment, antiparasitic, filarial infection, parasitic diseases, microfilariae, Brugia, Wuchereria, tropical medicine
539	Hypoglycemia increases the risk of dementia. hypoglycemia, dementia, risk factors, cognitive decline, blood glucose, neurodegeneration, diabetes, memory loss, elderly, brain function, insulin, metabolic disorders, Alzheimer's disease, hypoglycemic episodes, cognitive impairment hypoglycemia, dementia, risk factors, cognitive decline, blood glucose, neurodegeneration, elderly, diabetes, insulin, memory impairment, glucose metabolism, brain health, cognitive impairment, aging, neurological disorders hypoglycemia, dementia, cognitive decline, risk factors, low blood sugar, neurodegeneration, diabetes complications, elderly, brain health, glucose regulation, memory impairment, metabolic disorders, Alzheimer's disease, cognitive impairment hypoglycemia, dementia, risk factors, cognitive decline, blood glucose, neurodegeneration, elderly, diabetes, memory loss, brain function, insulin, Alzheimer's disease, glucose regulation, hypoglycemic episodes, cognitive impairment hypoglycemia, dementia, risk factors, cognitive impairment, low blood sugar, diabetes, neurodegeneration, elderly, brain health, glucose metabolism, memory loss, Alzheimer's disease, hypoglycemic episodes, mental decline
1099	Statins decrease blood cholesterol. statins, blood cholesterol, cholesterol lowering, lipid-lowering drugs, statin therapy, hypercholesterolemia, LDL reduction, cardiovascular disease prevention, cholesterol metabolism, statin mechanism statins, blood cholesterol, cholesterol reduction, lipid-lowering drugs, hypercholesterolemia, statin therapy, cholesterol-lowering medication, LDL reduction, statin efficacy, cardiovascular disease prevention statins, blood cholesterol, cholesterol reduction, lipid lowering drugs, hypercholesterolemia, statin therapy, LDL cholesterol, cholesterol management, cardiovascular drugs, cholesterol lowering agents statins, blood cholesterol, cholesterol reduction, lipid-lowering drugs, hypercholesterolemia, statin therapy, cholesterol-lowering medication, LDL cholesterol, cardiovascular risk, cholesterol management statins, blood cholesterol, cholesterol reduction, lipid-lowering drugs, statin therapy, hypercholesterolemia, cardiovascular disease, LDL cholesterol, cholesterol management, statin benefits, cholesterol lowering agents
660	Ivermectin is used to treat onchocerciasis. Ivermectin, onchocerciasis, treatment, antiparasitic, river blindness, therapy, uses, helminth infection, Ivermectin indications, Onchocerca volvulus, parasite control ivermectin, onchocerciasis, river blindness, antiparasitic, treatment, filarial infection, microfilariae, parasitic disease, therapeutic use, helminthiasis Ivermectin, onchocerciasis, treatment, river blindness, antiparasitic, therapy, uses, filarial infection, parasitic disease ivermectin, onchocerciasis, river blindness, treatment, antiparasitic, filarial infection, ivermectin therapy, symptoms, dosage, efficacy, helminth infection ivermectin, onchocerciasis, river blindness, antiparasitic, treatment, parasitic infection, filarial disease, therapeutic use, helminthiasis, medical therapy
781	Mice that lack Interferon-γ or its receptor exhibit high resistance to experimental autoimmune myocarditis. mice, Interferon-γ deficiency, IFN-γ knockout, interferon gamma receptor, autoimmune myocarditis, experimental myocarditis, resistance, immune response, murine model, cytokine signaling, cardiac inflammation, gene knockout, immunology, autoimmunity mice, Interferon-γ deficiency, IFN-γ knockout, IFN-γ receptor knockout, experimental autoimmune myocarditis, resistance, autoimmunity, cardiac inflammation, immune response, murine model, cytokine signaling, myocarditis susceptibility mice, Interferon-γ deficiency, IFN-γ knockout, Interferon gamma receptor, autoimmune myocarditis, resistance, experimental myocarditis, immunity, genetic knockout, EAM, murine model, immune response, cytokines, autoimmunity mice, Interferon-γ deficiency, IFN-γ knockout, interferon gamma receptor, autoimmune myocarditis, resistance, experimental model, immune response, cytokine, cardiac inflammation mice, Interferon-γ deficiency, interferon gamma receptor knockout, autoimmune myocarditis, resistance, experimental autoimmune myocarditis, IFN-γ, IFNGR, immune response, mouse model, inflammatory heart disease, immune deficiency, myocarditis resistance
540	Hypothalamic glutamate neurotransmission is crucial to energy balance. hypothalamic, glutamate, neurotransmission, energy balance, hypothalamus, glutamatergic signaling, metabolic regulation, neuronal pathways, appetite control, neurobiology, metabolism hypothalamic glutamate, neurotransmission, energy balance, hypothalamus, glutamate signaling, metabolic regulation, appetite control, central nervous system, feeding behavior, energy homeostasis, neural circuits, metabolism, excitatory neurotransmission, brain energy regulation, neurobiology hypothalamus, glutamate, neurotransmission, energy balance, hypothalamic regulation, glutamatergic signaling, metabolic control, appetite regulation, neuronal circuits, neurobiology, brain metabolism, feeding behavior hypothalamus, glutamate, neurotransmission, energy balance, metabolism, neurobiology, hypothalamic regulation, excitatory neurotransmitters, appetite control, neuronal signaling, brain energy homeostasis, feeding behavior, synaptic transmission, hypothalamic neurons, obesity, metabolic regulation hypothalamic, glutamate, neurotransmission, energy balance, hypothalamus, excitatory neurotransmitters, metabolism, appetite regulation, central nervous system, neural circuits, feeding behavior, energy homeostasis, obesity, synaptic transmission, neurobiology, brain energy regulation
783	Mice without IFN-γ or its receptor are resistant to EAM induced with α-MyHC/CFA. mice, IFN-γ deficiency, interferon gamma, IFN-γ receptor knockout, resistance, experimental autoimmune myocarditis, EAM, α-MyHC, alpha-myosin heavy chain, CFA, complete Freund's adjuvant, pathogenesis, immune response, cardiac autoimmunity, mouse model, gene knockout, cytokines mice, IFN-γ knockout, IFN-γ receptor deficient, EAM, α-MyHC, CFA, resistance, experimental autoimmune myocarditis, interferon gamma, immune response, gene knockout, cardiac autoimmunity IFN-γ knockout, IFN-γ receptor deficiency, resistance, EAM, experimental autoimmune myocarditis, α-MyHC, cardiac myosin, CFA, adjuvant, mouse model, immune response, interferon gamma, myocarditis susceptibility IFN-γ knockout, IFN-γ receptor deficiency, resistance, EAM, α-MyHC, CFA, experimental autoimmune myocarditis, mouse model, cardiac autoimmunity, interferon gamma, immune response, susceptibility, inflammation, myocardial antigen, disease induction mice, IFN-γ knockout, IFN-γ receptor deficiency, resistance, experimental autoimmune myocarditis, EAM, α-MyHC, cardiac myosin, CFA, complete Freund’s adjuvant, immune response, myocarditis, gene knockout, autoimmunity
300	Cytosolic proteins bind to iron-responsive elements on mRNAs coding for DMT1. Cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake. cytosolic proteins, iron-responsive elements, IRE, mRNA, DMT1, divalent metal transporter 1, iron uptake, iron regulation, protein-mRNA binding, post-transcriptional regulation, ferritin, transferrin receptor, iron metabolism, iron homeostasis, RNA-binding proteins cytosolic proteins, iron-responsive elements, mRNA, DMT1, iron uptake, iron metabolism, protein binding, IRE, post-transcriptional regulation, iron homeostasis, regulatory proteins, cellular iron, divalent metal transporter 1, gene expression, mRNA regulation cytosolic proteins, iron-responsive elements, IRE, mRNA binding, DMT1, divalent metal transporter 1, iron uptake, iron metabolism, post-transcriptional regulation, RNA-protein interaction, iron regulatory proteins, IRP, mRNA stability, iron homeostasis, translation regulation, gene expression cytosolic proteins, iron-responsive elements, IRE, mRNA, DMT1, divalent metal transporter 1, iron uptake, iron metabolism, mRNA binding, post-transcriptional regulation, iron homeostasis, iron regulatory proteins, IRP, protein-mRNA interaction, iron-related gene expression cytosolic proteins, iron-responsive elements, IRE, mRNA binding, DMT1, divalent metal transporter 1, iron uptake, iron regulation, post-transcriptional regulation, IRP, iron metabolism, mRNA translation, iron homeostasis
421	Flexible molecules experience greater steric hindrance in the tumor microenviroment than rigid molecules. flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, molecular conformation, intratumoral barriers, molecular size, drug delivery, tumor penetration, molecular interactions, cancer therapeutics flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, steric effects, tumor biology, drug delivery, molecular interactions flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, molecular rigidity, cancer, molecular interactions, structural hindrance, biological environment, conformational dynamics, tumor biology, drug delivery, molecular structure, tumor targeting flexible molecules, steric hindrance, tumor microenvironment, rigid molecules, molecular flexibility, molecular rigidity, tumor environment, molecular interactions, steric effects, cancer, molecular dynamics, biological barriers, molecule conformation, drug delivery, molecular structure flexible molecules, rigid molecules, steric hindrance, tumor microenvironment, molecular flexibility, molecular rigidity, molecular conformation, molecular dynamics, tumor tissue, spatial constraints, structural hindrance, cancer biology, molecular size, drug delivery, cell environment
784	MicroRNA is involved in the regulation of Neural Stem Cell (NSC) differentiation and proliferation dynamic homeostasis microRNA, neural stem cell, NSC, differentiation, proliferation, dynamic homeostasis, gene regulation, neurogenesis, stem cell fate, miRNA, cellular homeostasis, neural development, stem cell biology, molecular mechanisms, neural progenitor cells MicroRNA, neural stem cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, stem cell biology, neurogenesis, gene expression, cell fate, neural development, cellular homeostasis, miRNA, neural differentiation, stem cell proliferation microRNA, neural stem cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, neurogenesis, stem cell fate, gene expression, cellular homeostasis, neural development, epigenetic regulation, signaling pathways, brain development microRNA, neural stem cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, neural development, stem cell biology, gene expression, neurogenesis, cellular signaling, epigenetics, transcriptional regulation, brain development microRNA, neural stem cell, NSC, differentiation, proliferation, dynamic homeostasis, regulation, neurogenesis, stem cell fate, gene expression, epigenetic regulation, cell cycle, neural development, signaling pathways, miRNA, self-renewal, neural plasticity, transcriptome, molecular mechanisms
785	Microarray results from culture-amplified mixtures of serotypes correlate poorly with microarray results from uncultured mixtures. microarray, culture-amplified, serotypes, mixtures, correlation, uncultured, results, comparison, amplification, accuracy, detection, analysis, bacterial, diagnostics microarray, culture-amplified, serotypes, uncultured mixtures, correlation, microarray results, amplification, microbial mixtures, genomic analysis, comparative study, culture methods, signal variation, hybridization, sample preparation, serotype detection microarray, culture-amplified, serotypes, uncultured mixtures, correlation, microarray results, microbial analysis, sample preparation, amplification, serotype detection, comparative analysis, data correlation, mixed cultures microarray, culture-amplified, serotypes, uncultured mixtures, correlation, microarray results, bacterial cultures, serotype mixtures, amplification effect, comparative analysis, detection accuracy, mixed samples, microbial diagnostics microarray, culture-amplified mixtures, serotypes, uncultured mixtures, correlation, microarray results, comparative analysis, data reliability, bacterial serotyping, amplification effects
544	IFIT1 restricts viral replication by sequestrating mis-capped viral RNAs. IFIT1, viral replication, restriction, sequestration, mis-capped RNA, viral RNA, antiviral response, innate immunity, interferon-stimulated genes, cap recognition, RNA binding, viral inhibition IFIT1, viral replication, restriction, mis-capped RNA, RNA sequestration, innate immunity, antiviral response, interferon-stimulated genes, RNA cap recognition, virus-host interactions IFIT1, viral replication, restriction, sequestration, mis-capped viral RNA, antiviral mechanism, innate immunity, interferon-stimulated genes, RNA binding, viral inhibition, cap structure, host defense IFIT1, viral replication, restriction, sequestration, mis-capped RNA, viral RNA, antiviral response, innate immunity, RNA binding, RNA cap recognition, host defense, interferon-stimulated genes IFIT1, viral replication, sequestration, mis-capped viral RNA, antiviral restriction, interferon-stimulated genes, RNA binding, cap structure, innate immunity, viral inhibition
303	DMRT1 is a sex-determining gene that is epigenetically regulated by the MHM region. DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, sex determination, chromatin modification, DNA methylation, transcriptional regulation, avian sex differentiation, regulatory elements DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, sex determination, methylation, chromatin modification, dosage compensation, avian genetics, regulatory elements, non-coding RNA DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene regulation, sexual differentiation, methylation, chromatin modification, sex chromosomes, avian genetics DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, DNA methylation, chromatin modification, dosage compensation, avian sex determination, regulatory elements, chicken, Z chromosome, non-coding RNA, transcriptional regulation DMRT1, sex-determining gene, epigenetic regulation, MHM region, gene expression, sexual differentiation, chromatin modification, DNA methylation, sex chromosomes, gonadal development
1089	Smc5/6 engagment drives the activation of SUMO E3 ligase Mms21 by ATP-dependent remolding. Smc5/6, SUMO E3 ligase, Mms21, ATP-dependent, remodeling, activation, SUMOylation, DNA repair, chromatin remodeling, protein-protein interaction, ubiquitin-like modification, ATP hydrolysis, enzyme activation Smc5/6, SUMO E3 ligase, Mms21, activation, ATP-dependent remodeling, SUMOylation, enzymatic regulation, chromatin, protein complex, genome stability Smc5/6, SUMO E3 ligase, Mms21, ATP-dependent, remodeling, activation, engagement, SUMOylation, protein complex, DNA repair, chromatin, ubiquitin-like modification Smc5/6, SUMO E3 ligase, Mms21, ATP-dependent remodeling, activation, engagement, SUMOylation, protein complex, chromatin, DNA repair, enzymatic activity, molecular mechanism Smc5/6, engagement, activation, SUMO E3 ligase, Mms21, ATP-dependent, remodeling, SUMOylation, chromatin, complex, enzymatic regulation, DNA repair, structural maintenance, post-translational modification
549	IRG1 has antiviral effects against neurotropic viruses. IRG1, antiviral, neurotropic viruses, immune response, itaconate, central nervous system, viral inhibition, neuroinflammation, antiviral mechanisms, neurotropic viral infection IRG1, antiviral, neurotropic viruses, immune response, itaconate, neuroprotection, viral infection, interferon, CNS, innate immunity, inflammation, brain, viral pathogenesis, microglia, antiviral mechanisms IRG1, antiviral effects, neurotropic viruses, immune response, itaconate, CNS infection, brain viruses, viral encephalitis, antiviral mechanism, innate immunity, IFN pathway, viral replication, neuroprotection, IRG1 gene, infection control IRG1, antiviral effects, neurotropic viruses, immune response, itaconate, viral inhibition, brain infection, neuroinflammation, virus replication, antiviral mechanism, CNS infection, innate immunity, central nervous system, IRG1-mediated defense IRG1, antiviral effects, neurotropic viruses, immune response, itaconic acid, central nervous system, viral infection, neuroinflammation, IRG1 mechanism, brain infection, antiviral immunity, IRG1 expression, viral replication inhibition, neurotropic viral pathogens
551	ITAM phosphorylation prevents the transfer of the T cell receptor (TCR) signal from the echo-domain to the cytoplasmic tail of the T cell receptor (TCR). ITAM phosphorylation, T cell receptor, TCR, signal transduction, echo-domain, cytoplasmic tail, phosphorylation mechanism, TCR signaling, immune signaling, ITAM, signal prevention, immune response, T cell activation ITAM phosphorylation, T cell receptor, TCR, signal transduction, cytoplasmic tail, echo-domain, immune signaling, TCR signaling, phosphorylation mechanism, signal prevention, immunoreceptor, intracellular signaling, T cell activation, ITAM, protein phosphorylation ITAM phosphorylation, T cell receptor, TCR signaling, signal transduction, echo-domain, cytoplasmic tail, T cell activation, TCR signal transfer, immune signaling, ITAM function, TCR cytoplasmic domain, T cell signaling pathway, phosphorylation effects ITAM phosphorylation, T cell receptor, TCR signaling, signal transduction, cytoplasmic tail, echo-domain, phosphorylation inhibition, immune signaling, TCR activation, signal prevention, immunoreceptor tyrosine-based activation motif, T cell activation, molecular signaling pathways, TCR cytoplasmic region ITAM phosphorylation, T cell receptor, TCR signaling, signal transduction, echo-domain, cytoplasmic tail, phosphorylation effect, immune signaling, TCR activation, inhibitory mechanism, signal prevention, immunoreceptor tyrosine-based activation motif, T cell activation, molecular mechanism
793	Mitochondria are uninvolved in apoptosis. mitochondria, apoptosis, mitochondrial involvement, cell death, mitochondrial apoptosis, apoptosis pathways, mitochondrial function, mitochondria-independent apoptosis, mitochondrial signaling, programmed cell death, non-mitochondrial apoptosis mitochondria, apoptosis, mitochondrial involvement, cell death, apoptosis pathways, mitochondrial role, intrinsic pathway, extrinsic pathway, apoptosis mechanism, mitochondrial independence, cell signaling, apoptosis regulation mitochondria, apoptosis, mitochondrial involvement, cell death, apoptosis pathways, mitochondrial role, programmed cell death, mitochondrial independence, apoptosis mechanisms, mitochondrial function, apoptosis regulation, mitochondrial signaling mitochondria, apoptosis, mitochondrial involvement, cell death, intrinsic pathway, extrinsic pathway, cytochrome c, caspase activation, mitochondrial independence, cell signaling, programmed cell death, mitochondrial role, apoptosis pathways mitochondria, apoptosis, cell death, mitochondrial pathway, intrinsic apoptosis, mitochondrial involvement, apoptosis mechanisms, mitochondrial independence, apoptosis regulation, mitochondrial signaling
431	FoxO3a activation in neuronal death is mediated by reactive oxygen species (ROS). FoxO3a, activation, neuronal death, reactive oxygen species, ROS, oxidative stress, signaling pathways, neurodegeneration, apoptosis, transcription factor, cell death, neurobiology, neuroprotection FoxO3a, neuronal death, activation, reactive oxygen species, ROS, neurodegeneration, oxidative stress, cell signaling, apoptosis, transcription factor, brain injury FoxO3a, activation, neuronal death, reactive oxygen species, ROS, neurodegeneration, oxidative stress, apoptosis, signaling pathways, transcription factor, cell death, neurotoxicity, neuron, oxidative damage, mediators FoxO3a activation, neuronal death, reactive oxygen species, ROS, oxidative stress, neurodegeneration, apoptosis, signaling pathways, transcription factors, cell death, brain injury, oxidative signaling FoxO3a, activation, neuronal death, reactive oxygen species, ROS, neurodegeneration, oxidative stress, apoptosis, cell signaling, transcription factor, neurotoxicity, neuron, pathway, cell death
552	IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa on commencement of a gluten-free diet. IgA plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, mucosal immunity, TG2-specific IgA, autoimmune response, intestinal biopsy, immune accumulation, gluten withdrawal IgA, plasma cells, transglutaminase 2, TG2, duodenal mucosa, gluten-free diet, celiac disease, autoantibodies, mucosal immunity, gluten removal, intestinal immune response, disease biomarkers, dietary intervention, adaptive immunity, antibody accumulation IgA plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, mucosal immunity, autoantibodies, intestinal immunity, TG2-specific antibodies, immune response, dietary intervention IgA plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, autoantibodies, intestinal immunity, mucosal accumulation, TG2-specific, immune response, gluten withdrawal, adaptive immunity IgA plasma cells, transglutaminase 2, duodenal mucosa, gluten-free diet, celiac disease, autoantibodies, mucosal immunity, antigen specificity, intestinal immunology, disease onset, dietary intervention
674	LDL cholesterol has no involvement in the development of cardiovascular disease. LDL cholesterol, cardiovascular disease, LDL involvement, heart disease risk, lipid hypothesis, cholesterol controversy, atherosclerosis, coronary artery disease, LDL-C, cholesterol and CVD, cholesterol myth, cardiovascular risk factors, cholesterol debate, LDL and heart disease, cholesterol and inflammation LDL cholesterol, cardiovascular disease, LDL involvement, cholesterol role, CVD, cardiovascular risk, atherosclerosis, lipid hypothesis, cholesterol causation, heart disease, cholesterol debate, LDL controversy, cardiovascular health, cholesterol evidence, CVD development LDL cholesterol, cardiovascular disease, LDL involvement, cholesterol and heart disease, LDL atherogenesis, lipid hypothesis, cholesterol controversy, CVD risk factors, LDL evidence, cardiovascular health, LDL and atherosclerosis, LDL causality, heart disease mechanisms, cholesterol myths LDL cholesterol, cardiovascular disease, LDL involvement, heart disease, cholesterol controversy, lipid hypothesis, cholesterol myth, CVD risk factors, cholesterol causation, cardiovascular risk, LDL correlation, cholesterol and atherosclerosis, lipid profile, cardiovascular health, cholesterol evidence LDL cholesterol, cardiovascular disease, LDL involvement, atherosclerosis, heart disease, cholesterol myths, LDL evidence, cardiovascular risk factors, lipid hypothesis, LDL controversy, cholesterol research, lipid profile, cardiovascular health, cholesterol causality, LDL-c, CVD, heart health, lipid theory, cholesterol debate, LDL impact
312	De novo assembly of sequence data has more specific contigs than unassembled sequence data. de novo assembly, sequence data, contigs, unassembled sequence, genome assembly, specific contigs, assembled data, sequence assembly, bioinformatics, next-generation sequencing, read assembly, assembly accuracy, genomic contigs, sequence reconstruction de novo assembly, sequence data, specific contigs, unassembled sequence data, genome assembly, bioinformatics, contig specificity, assembly quality, sequencing, reads assembly, sequence alignment, assembled vs unassembled, contig generation, next-generation sequencing de novo assembly, sequence data, specific contigs, unassembled sequence, genome assembly, contig specificity, assembled vs unassembled, bioinformatics, sequence reconstruction, assembly accuracy, next-generation sequencing de novo assembly, sequence data, contigs, specific contigs, unassembled sequence data, genome assembly, sequencing, bioinformatics, assembly quality, contig specificity, sequence reconstruction de novo assembly, sequence data, specific contigs, unassembled sequence data, genome assembly, contig specificity, sequencing, bioinformatics, assembly comparison, sequence assembly quality
554	Immune complex triggered cell death leads to extracellular release of neutrophil protein HMGB1. immune complex, cell death, extracellular release, neutrophil, HMGB1, neutrophil extracellular traps, inflammation, immune response, extracellular HMGB1, neutrophil-mediated cell death, DAMPs, immune-mediated cytotoxicity, NETosis, high mobility group box 1 immune complexes, cell death, extracellular release, neutrophil, HMGB1, neutrophil extracellular traps, inflammation, immune response, apoptosis, necrosis, DAMPs, protein release immune complex, cell death, neutrophil, HMGB1, extracellular release, immune response, protein release, NETosis, inflammation, DAMPs, high mobility group box 1, neutrophil extracellular traps, immunology, apoptosis, necrosis immune complex, cell death, extracellular release, neutrophil, HMGB1, neutrophil protein, immunogenic cell death, extracellular HMGB1, immune response, NETosis, high mobility group box 1, cell lysis, inflammation, immune-mediated cell death, DAMPs immune complex, cell death, extracellular release, neutrophil, HMGB1, neutrophil protein, immune response, apoptosis, necrosis, inflammation, NETosis, high mobility group box 1, release mechanisms, immune-mediated cell death
314	Deamination of cytidine to uridine on the minus strand of viral DNA results in catastrophic G-to-A mutations in the viral genome. cytidine deamination, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, APOBEC, hypermutation, antiviral defense, DNA editing, mutagenesis, virology, genetic variation, nucleotide substitution, host restriction factors deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, APOBEC, hypermutation, antiviral defense, RNA editing, mutagenesis, DNA editing, nucleotide conversion cytidine deamination, uridine conversion, minus strand, viral DNA, G-to-A mutations, APOBEC, viral genome, hypermutation, antiviral defense, nucleotide editing, cytidine to uridine, reverse transcription, genetic mutagenesis deamination, cytidine, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, mutagenesis, APOBEC, DNA editing, nucleotide conversion, antiviral defense cytidine deamination, uridine, minus strand, viral DNA, G-to-A mutations, viral genome, APOBEC, antiviral defense, mutagenesis, DNA editing, nucleotide substitution, hypermutation, retroviral replication
436	Free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated. free histones, degradation, Rad53-dependent mechanism, DNA replication, histone turnover, DNA synthesis, post-replication, Rad53 kinase, histone degradation pathway, chromatin, cell cycle, protein degradation free histones, degradation, Rad53-dependent, DNA replication, histone turnover, post-replication, Rad53 kinase, chromatin, DNA synthesis, histone stability, cell cycle, checkpoint pathway free histones, histone degradation, Rad53-dependent, DNA replication, Rad53 kinase, chromatin, proteolysis, post-replication, yeast, checkpoint pathway, protein turnover free histones, degradation, Rad53-dependent, DNA replication, histone turnover, replication-coupled degradation, Rad53 kinase, chromatin, Saccharomyces cerevisiae, DNA damage response, histone regulation, histone metabolism free histones, degradation, Rad53-dependent, DNA replication, histone turnover, DNA repair, chromatin, cell cycle, checkpoint kinase, genome stability
437	Functional consequences of genomic alterations due to Myelodysplastic syndrome (MDS) are poorly understood due to the lack of an animal model. Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, disease modeling, pathogenesis, genetic mutations, hematological malignancies, in vivo studies, mouse model, disease mechanisms, gene function, translational research, preclinical models Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal models, disease modeling, pathogenesis, hematopoietic disorders, genetic mutations, molecular mechanisms, preclinical models, translational research Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, disease modeling, genetic mutations, pathogenesis, hematopoiesis, in vivo studies, molecular mechanisms, preclinical models, experimental models, model organisms, translational research Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, disease modeling, pathogenesis, gene mutations, hematopoiesis, preclinical models, in vivo studies, dysplasia, molecular mechanisms, translational research, hematologic malignancies Myelodysplastic syndrome, MDS, genomic alterations, functional consequences, animal model, disease modeling, pathogenesis, genetic mutations, preclinical models, hematological malignancies, in vivo studies, translational research, molecular mechanisms, gene function, functional genomics
439	Fz/PCP-dependent Pk localizes to the anterior membrane of neuroectoderm cells during zebrafish neuralation Fz, Frizzled, PCP, Planar Cell Polarity, Pk, Prickle, anterior membrane, neuroectoderm cells, zebrafish, neurulation, protein localization, cell polarity, neural development, embryogenesis, membrane localization Fz, PCP, Pk, anterior membrane, neuroectoderm cells, zebrafish, neurulation, localization, planar cell polarity, frizzled, prickle, cell polarity, neural development, embryogenesis Fz, PCP, Prickle, Pk, localization, anterior membrane, neuroectoderm cells, zebrafish, neurulation, planar cell polarity, cell polarity, membrane localization, neural development Fz, PCP, Prickle, Pk, localization, anterior membrane, neuroectoderm cells, zebrafish, neurulation, planar cell polarity, Frizzled, neural development, embryogenesis, cell polarity, membrane targeting Fz, PCP, Prickle, Pk, anterior membrane, neuroectoderm cells, zebrafish, neurulation, localization, planar cell polarity, Frizzled, neural development
560	Immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs. immune response, Th17 cells, inflammatory, iTregs, anti-inflammatory, T cell differentiation, regulatory T cells, inflammation, immune regulation, T helper cells, cytokines, immune system, immunology immune responses, Th17 cells, inflammatory, iTregs, anti-inflammatory, T helper 17, regulatory T cells, differentiation, immune regulation, inflammation, T cell subsets, adaptive immunity, immunology, cytokines, immune balance immune response, inflammatory Th17 cells, anti-inflammatory iTregs, T helper 17, induced regulatory T cells, inflammation, immune regulation, cytokines, immune modulation, immune homeostasis, T cell differentiation immune responses, inflammatory Th17 cells, anti-inflammatory iTregs, T helper 17, regulatory T cells, inflammation, immunoregulation, Th17 differentiation, iTreg induction, cytokines, immune balance, autoimmune diseases, tolerance, T cell subsets, immune homeostasis immune responses, Th17 cells, inflammatory, iTregs, anti-inflammatory, T helper 17, regulatory T cells, inflammation, immune regulation, adaptive immunity, cytokines, T cell differentiation, autoimmunity, immune homeostasis
440	Fz/PCP-dependent Pk localizes to the anterior membrane of notochord cells during zebrafish neuralation. Fz, PCP, Pk, anterior membrane, notochord cells, zebrafish, neuralation, localization, planar cell polarity, Frizzled, Prickle, embryonic development, cell polarity, membrane targeting, vertebrate morphogenesis Fz, PCP, Pk, Prickle, anterior membrane, notochord cells, zebrafish, neurulation, localization, Planar Cell Polarity, Frizzled, cell polarity, developmental biology, neural development, embryo, membrane localization Fz, PCP, Prickle, Pk, anterior membrane, notochord cells, localization, zebrafish, neurulation, cell polarity, planar cell polarity, embryonic development, protein localization, Fz/PCP pathway, zebrafish embryo Fz, PCP, Pk localization, anterior membrane, notochord cells, zebrafish, neurulation, planar cell polarity, Frizzled, Prickle, cellular polarity, embryonic development, protein localization, zebrafish embryo, neural tube formation Fz, PCP, Pk, localization, anterior membrane, notochord cells, zebrafish, neurulation, planar cell polarity, protein distribution, developmental biology, embryogenesis, membrane polarity, cell signaling, zebrafish embryo
1303	Tirasemtiv has no effect on fast-twitch muscle. Tirasemtiv, fast-twitch muscle, skeletal muscle, drug effect, muscle physiology, muscle contraction, muscle fiber type, pharmacology, muscle performance, neuromuscular, clinical study, Tirasemtiv efficacy, negative results, muscle strength, myopathy, muscle disease, Tirasemtiv mechanism, contractility, therapeutic effect, selective action Tirasemtiv, fast-twitch muscle, no effect, muscle fibers, skeletal muscle, drug response, muscle performance, muscle contraction, pharmacology, muscle physiology Tirasemtiv, fast-twitch muscle, no effect, muscle fiber type, skeletal muscle, pharmacology, muscle physiology, drug response, muscle contraction, muscle performance, muscle types, muscle selectivity Tirasemtiv, fast-twitch muscle, muscle contraction, muscle fiber type, skeletal muscle, drug effect, pharmacology, muscle physiology, muscle performance, clinical studies, neuromuscular, type II muscle fibers, negative results, muscle strength, pharmacodynamics Tirasemtiv, fast-twitch muscle, skeletal muscle, muscle contraction, muscle fiber type, pharmacology, drug effect, muscle physiology, muscle function, neuromuscular, therapeutic effect, clinical trial, muscle performance, muscle strength, muscle selectivity, calcium sensitizer
684	Lack of clpC does not affect sporulation efficiency in Bacillus subtilis cells. clpC, sporulation efficiency, Bacillus subtilis, gene knockout, sporulation, bacterial sporulation, clpC deletion, cell differentiation, spore formation, genetic mutation, regulatory proteins, sporulation pathway, Bacillus genetics clpC, sporulation efficiency, Bacillus subtilis, gene knockout, sporulation, protein degradation, clpC mutation, bacterial sporulation, germination, clpC function, Bacillus genetics, spore formation, phenotype analysis clpC deletion, sporulation efficiency, Bacillus subtilis, clpC knockout, spore formation, clpC gene, bacterial sporulation, clpC mutant, sporulation process, clpC function, Bacillus subtilis mutants, genetic regulation, sporulation phenotype, molecular biology clpC, sporulation efficiency, Bacillus subtilis, clpC deletion, clpC knockout, sporulation, effect, bacterial sporulation, clpC mutant, sporulation phenotype, clpC gene, Bacillus subtilis mutants clpC, sporulation efficiency, Bacillus subtilis, clpC deletion, sporulation, clpC knockout, spore formation, clpC mutant, Bacillus subtilis sporulation, gene knockout effects, bacterial sporulation, clpC function
443	GATA-3 is important for hematopoietic stem cell (HSC) function. GATA-3, hematopoietic stem cell, HSC, stem cell function, transcription factor, hematopoiesis, gene regulation, stem cell maintenance, blood cell development, immune system, progenitor cells GATA-3, hematopoietic stem cells, HSC, stem cell function, transcription factor, hematopoiesis, gene regulation, differentiation, self-renewal, lineage commitment, molecular mechanisms, immune system, blood cell development GATA-3, hematopoietic stem cell, HSC, stem cell function, gene regulation, transcription factor, hematopoiesis, blood cell development, GATA3, stem cell maintenance, differentiation GATA-3, hematopoietic stem cell, HSC, function, transcription factor, gene regulation, hematopoiesis, stem cell differentiation, blood cell development, HSC maintenance, lineage specification GATA-3, hematopoietic stem cell, HSC, function, hematopoiesis, transcription factor, stem cell differentiation, gene regulation, stem cell maintenance, immune system, lineage commitment, blood cell development
324	Deleting Raptor reduces G-CSF levels. Raptor deletion, G-CSF reduction, mTOR pathway, Raptor knockout, granulocyte colony-stimulating factor, immune regulation, hematopoiesis, cytokine levels, Raptor function, myeloid cells Raptor deletion, G-CSF reduction, mTORC1, granulocyte colony-stimulating factor, Raptor knockout, cytokine regulation, hematopoiesis, immune response, gene editing, protein expression Raptor deletion, G-CSF reduction, mTORC1, myeloid cells, granulocyte colony-stimulating factor, immune regulation, knockout mice, cytokine levels, hematopoiesis, inflammation, signaling pathway, neutrophil production Raptor, deletion, G-CSF, granulocyte colony-stimulating factor, gene knockout, immune regulation, mTORC1, cytokine levels, hematopoiesis, immune cells Raptor deletion, G-CSF reduction, G-CSF levels, Raptor knockout, gene deletion, granulocyte colony-stimulating factor, molecular signaling, immune response, mTOR pathway, cytokine regulation, hematopoiesis, myeloid cells, inflammatory modulation
327	Deletion of αvβ8 does not result in a spontaneous inflammatory phenotype. αvβ8 deletion, spontaneous inflammatory phenotype, inflammation, integrin αvβ8, knockout, immune response, mouse model, phenotype analysis, TGF-β activation, immune regulation, experimental deletion, inflammatory disease, autoimmunity αvβ8 deletion, spontaneous inflammation, inflammatory phenotype, knockout mouse, TGF-β signaling, immune response, integrin αvβ8, genetic ablation, inflammation pathway, immune tolerance αvβ8 deletion, inflammatory phenotype, integrin αvβ8, spontaneous inflammation, immune response, knockout mouse model, inflammation markers, gene deletion, TGF-β activation, immunology αvβ8 deletion, spontaneous inflammatory phenotype, inflammation, immune response, integrin αvβ8, knockout mouse, phenotype analysis, immune regulation, inflammatory signaling, integrin deletion effects αvβ8 deletion, spontaneous inflammation, inflammatory phenotype, integrin αvβ8, knockout mouse, immune response, tissue homeostasis, inflammation markers, integrin deficiency, phenotype analysis
569	In adult tissue, most T cells are memory T cells. adult tissue, T cells, memory T cells, immune cells, lymphocytes, immunology, tissue-resident T cells, memory phenotype, T cell subsets, adult immune system adult tissue, memory T cells, T cell populations, adult immune system, T cell subsets, immunological memory, mature T cells, T cell differentiation, tissue-resident memory T cells, adaptive immunity adult tissue, T cells, memory T cells, immune system, lymphocytes, T cell subsets, adult immune response, memory lymphocytes, immunology, tissue-resident T cells adult tissue, T cells, memory T cells, immunology, lymphocytes, adaptive immunity, T cell subsets, tissue-resident memory T cells, immune memory, T cell populations adult tissue, memory T cells, T cell subsets, immune system, effector memory, central memory, naïve T cells, immunology, T cell differentiation, tissue-resident memory T cells, lymphocytes, adaptive immunity, adult immunity
208	CHEK2 is not associated with breast cancer. CHEK2, breast cancer, association, genetic risk, cancer susceptibility, gene mutation, negative correlation, hereditary cancer, genetic marker, oncogene, tumor suppressor, risk factor CHEK2, breast cancer, association, genetic risk, mutation, susceptibility, non-association, negative correlation, gene, oncology, hereditary cancer, biomarker, case-control, variant, cancer genetics CHEK2, breast cancer, association, gene mutation, cancer risk, genetic variant, non-association, susceptibility, prognosis, genetic testing, CHEK2 negative, oncogene, tumor suppressor, DNA repair, hereditary cancer CHEK2, breast cancer, association, genetic risk, negative correlation, cancer genetics, susceptibility, mutation, variant, non-association, hereditary breast cancer, tumor suppressor, gene, epidemiology, polymorphism CHEK2, breast cancer, genetic association, cancer risk, mutation, negative association, susceptibility, gene variant, hereditary cancer, oncogenetics, CHEK2 mutation, non-association, breast cancer genes, cancer predisposition, relationship, CHEK2 gene
690	Less than 10% of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, lactate >5mmol/L, prevalence, incidence, metabolic abnormalities, pediatric, rare genetic disorders, Gabon, Africa, epidemiology, clinical features, biochemical markers Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, lactate >5mmol/L, prevalence, metabolic abnormality, pediatric, rare disease, epidemiology, biochemical marker Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, lactate level, less than 10%, more than 5mmol/L, metabolic abnormalities, pediatric, rare disease, clinical data, incidence, Africa, lactate concentration, case study Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, elevated lactate, >5mmol/L, less than 10%, prevalence, metabolic markers, rare syndromes, pediatric, Africa, clinical study, inborn errors of metabolism Gabonese children, Schimmelpenning-Feuerstein-Mims syndrome, SFM, plasma lactate, >5mmol/L, less than 10%, metabolic biomarkers, pediatric, rare disease, hyperlactatemia, clinical study, incidence, Africa, lactate levels, epidemiology
691	Leukemia associated Rho guanine nucleotide-exchange factor represses RhoA in response to SRC activation. Leukemia associated Rho guanine nucleotide-exchange factor, RhoGEF, RhoA, SRC activation, RhoA repression, leukemogenesis, GEF, Rho GTPase, signal transduction, SRC kinase, molecular pathway, cellular signaling, oncogenesis Leukemia, Rho guanine nucleotide-exchange factor, RhoGEF, RhoA, repression, SRC activation, signal transduction, cellular signaling, leukemogenesis, GTPase, molecular pathways, phosphorylation Leukemia, Rho guanine nucleotide-exchange factor, RhoGEF, RhoA, repression, SRC activation, signal transduction, leukemia-associated RhoGEF, molecular mechanism, guanine nucleotide exchange, SRC kinase, cellular signaling, RhoA regulation Leukemia, Rho guanine nucleotide-exchange factor, RhoGEF, RhoA, SRC activation, SRC kinase, signal transduction, repression, molecular mechanism, hematological malignancy, cell signaling, phosphorylation, GTPase, leukemia biology, oncogenic pathway Leukemia, Rho guanine nucleotide-exchange factor, RhoGEF, RhoA, repression, SRC activation, signal transduction, cellular signaling, hematologic malignancy, GTPase regulation
692	Leuko-increased blood increases infectious complications in red blood cell transfusion. leuko-reduction, leukoreduced blood, infectious complications, red blood cell transfusion, transfusion risks, blood transfusion infection, leukocytes, transfusion-related infection, blood safety, immune response, blood product contamination, transfusion immunology, blood component therapy, transfusion-transmitted infection leuko-increased blood, leukocytes, infectious complications, red blood cell transfusion, transfusion infection risk, leukoreduction, blood transfusion complications, immune response, transfusion-related infection, white blood cells, infection prevention, blood safety, transfusion immunology leukocytes, elevated white blood cells, infectious complications, red blood cell transfusion, transfusion-related infections, leukoreduction, blood transfusion safety, immune response, transfusion outcomes, leukocytosis, post-transfusion infection leukocytosis, infectious complications, red blood cell transfusion, leukoreduction, transfusion-related infection, elevated white blood cells, transfusion risks, blood transfusion infection, leukocyte-mediated infection, blood component therapy leuko-increased blood, infectious complications, red blood cell transfusion, leukocytosis, transfusion infection risk, white blood cells, transfusion reactions, blood contamination, immunomodulation, transfusion-related infection
1316	Transferred UCB T cells acquire a memory-like phenotype in recipients. UCB, T cells, memory-like phenotype, transferred, recipients, adoptive transfer, phenotypic change, immunotherapy, umbilical cord blood, immune memory, transplantation, T cell differentiation, cell acquisition UCB, T cells, transferred, memory-like phenotype, recipients, adoptive transfer, immune memory, phenotypic change, cord blood, immunology, T cell differentiation, memory T cells, transplantation UCB T cells, memory-like phenotype, transferred T cells, recipients, T cell differentiation, adoptive transfer, immune memory, umbilical cord blood, T cell phenotype, immunology, transplantation, cellular memory, T cell adaptation UCB T cells, transferred T cells, memory-like phenotype, recipients, adoptive transfer, T cell differentiation, immune memory, umbilical cord blood, T cell phenotype, immunotherapy UCB T cells, memory-like phenotype, transferred T cells, recipients, T cell differentiation, adoptive transfer, umbilical cord blood, immune memory, phenotype acquisition, immunotherapy
693	Leuko-reduced blood reduces infectious complications in red blood cell transfusion. leuko-reduced blood, leukoreduction, infectious complications, red blood cell transfusion, blood transfusion, infection risk, transfusion safety, leukocyte reduction, transfusion-related infection, immunomodulation, RBC transfusion, transfusion outcomes leuko-reduced blood, leukoreduction, infectious complications, red blood cell transfusion, transfusion infection risk, blood transfusion safety, RBC transfusion, leukocyte depletion, transfusion-transmitted infection, clinical outcomes, immunomodulation, hospital-acquired infection leuko-reduced blood, leukoreduction, infectious complications, red blood cell transfusion, RBC transfusion, blood transfusion safety, infection risk, transfusion-related infection, filtered blood, immunomodulation, transfusion outcomes, leukocyte depletion, transfusion transmissible infections leuko-reduced blood, leukoreduction, infectious complications, red blood cell transfusion, transfusion-related infection, blood transfusion safety, white blood cell removal, transfusion-transmitted infection, immunomodulation, transfusion outcomes, infection prevention, blood product filtration leuko-reduced blood, infectious complications, red blood cell transfusion, leukoreduction, transfusion infection, blood safety, transfusion medicine, reduced leukocytes, immunomodulation, transfusion outcomes
452	Gene expression does not vary appreciably across genetically identical cells. gene expression, variability, genetically identical cells, expression heterogeneity, gene regulation, single-cell analysis, transcriptional noise, cellular homogeneity, expression stability, cell-to-cell variation gene expression, variability, genetically identical cells, cell-to-cell variation, expression heterogeneity, isogenic cells, transcriptional variation, molecular biology, stable gene expression, uniform expression, single-cell analysis, expression noise, gene regulation gene expression, variability, genetically identical cells, cell-to-cell variation, uniform expression, expression stability, transcriptomics, single-cell analysis, homogeneity, gene regulation, cellular heterogeneity, expression noise, gene expression consistency gene expression, variability, genetically identical cells, cell-to-cell variation, transcriptional noise, expression stability, expression heterogeneity, single-cell analysis, gene regulation, isogenic cells, uniform gene expression, cellular homogeneity gene expression, variability, genetically identical cells, expression stability, cell-to-cell variation, transcriptional heterogeneity, gene regulation, single-cell analysis, uniform expression, cellular homogeneity
212	CR is associated with higher methylation age. caloric restriction, CR, methylation age, DNA methylation, epigenetic aging, biological aging, aging biomarkers, methylation markers, longevity, age-related methylation, CR effects, epigenetics, lifespan extension caloric restriction, CR, methylation age, DNA methylation, epigenetic aging, biological aging, aging biomarkers, caloric intake, lifespan, longevity, age-related methylation caloric restriction, CR, methylation age, DNA methylation, epigenetic aging, aging biomarkers, lifespan, aging, calorie restriction, biological age, epigenetics, methylation markers caloric restriction, CR, methylation age, DNA methylation, epigenetic age, age acceleration, longevity, aging biomarkers, caloric intake, biological aging, lifespan, epigenetics, methylation markers caloric restriction, CR, DNA methylation, methylation age, epigenetic aging, biological age, age acceleration, lifespan, aging biomarkers, CR effects, methylation biomarkers
575	In domesticated populations of Saccharomyces cerevisiae, whole chromosome aneuploidy is very uncommon. Saccharomyces cerevisiae, domesticated, populations, whole chromosome, aneuploidy, rarity, frequency, karyotype, yeast, genome stability Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, yeast, aneuploidy frequency, genome stability, chromosome variation, domestication, chromosomal abnormalities, rare aneuploidy Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, chromosomal abnormalities, yeast genetics, genome stability, aneuploidy frequency, yeast domestication, chromosome number variation, genetic variation, yeast evolution Saccharomyces cerevisiae, domesticated populations, whole chromosome, aneuploidy, chromosome abnormalities, frequency, yeast genetics, genome stability, chromosomal variation, rarity Saccharomyces cerevisiae, domesticated populations, whole chromosome aneuploidy, chromosomal abnormalities, yeast genetics, chromosome variation, aneuploidy frequency, genetic diversity, yeast domestication, genomic instability
213	CRP is not predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. CRP, C-reactive protein, postoperative mortality, CABG, coronary artery bypass graft, predictive value, cardiac surgery, biomarkers, risk assessment, surgical outcomes, mortality prediction, heart surgery, prognostic factors CRP, C-reactive protein, postoperative mortality, CABG, coronary artery bypass graft, predictive value, biomarker, cardiovascular surgery, outcome prediction, perioperative risk, heart surgery, mortality risk, surgical prognosis, inflammation marker, risk assessment CRP, C-reactive protein, postoperative mortality, prediction, prognostic marker, Coronary Artery Bypass Graft, CABG, cardiovascular surgery, outcomes, biomarker, cardiac surgery, risk assessment, mortality rate, surgery prognosis, inflammation marker CRP, C-reactive protein, predictive value, postoperative mortality, coronary artery bypass graft, CABG, surgery outcomes, prognostic marker, cardiac surgery, risk prediction, mortality prediction, cardiovascular surgery, biomarker, perioperative morbidity, surgical prognosis, inflammatory markers, clinical outcomes, postoperative complications CRP, C-reactive protein, predictive value, postoperative mortality, CABG, coronary artery bypass graft, cardiac surgery, outcomes, prognostic marker, risk assessment, surgical mortality, inflammation, perioperative biomarkers
577	In mice, P. chabaudi parasites are able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers. P. chabaudi, mice, parasite proliferation, infection, inoculum size, early infection, parasite growth rate, low inoculation, high inoculation, dose-dependent, malaria, Plasmodium chabaudi, host-parasite interaction, parasite density, infection dynamics mice, Plasmodium chabaudi, parasite proliferation, infection, inoculum size, low dose, high dose, early infection, parasite growth rate, malaria, murine model, host-parasite interaction, infectious dose effect, parasite dynamics P. chabaudi, mice, parasite proliferation, infection, inoculum size, low dose, high dose, early infection, growth rate, parasitemia, malaria, host-pathogen interactions, dose-dependent, rodent model P. chabaudi, mice, parasite proliferation, infection, inoculum size, low inoculum, high inoculum, early infection, parasite growth rate, malaria, dose-dependent, parasitemia, experimental infection, murine model, Plasmodium chabaudi mice, Plasmodium chabaudi, parasite proliferation, infection, inoculum size, parasite growth rate, low inoculum, high inoculum, early infection, malaria, host-parasite interaction, experimental infection, dose-dependent growth
578	In mouse models, the loss of CSF1R facilitates MOZ-TIF2-induced leuekmogenesis. mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, leukemia, acute myeloid leukemia, AML, gene knockout, myeloid differentiation, oncogenesis, hematopoiesis, chromosomal translocation, experimental models, molecular mechanisms, cancer biology mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, leukemia, myeloid malignancy, gene knockout, oncogenesis, transcription factors, hematopoiesis, experimental models, cancer research, murine, fusion proteins, pathogenesis mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, leukemia, myeloid malignancy, hematopoiesis, oncogenesis, gene knockout, molecular mechanism, disease model, transcriptional regulation mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, leukemia, genetic models, hematopoiesis, oncogenesis, myeloid malignancy, transcriptional regulation mouse models, CSF1R loss, MOZ-TIF2, leukemogenesis, leukemia, myeloid malignancy, gene knockout, hematopoiesis, oncogenesis, experimental mice, molecular mechanism, cancer genetics, myeloid leukemia
216	CX3CR1 on the Th2 cells impairs T cell survival CX3CR1, Th2 cells, T cell survival, CX3CR1 expression, Th2 lymphocytes, T cell apoptosis, chemokine receptor, immune regulation, T helper 2, cell death, CX3CR1 function, T cell persistence, immunology, CX3CR1 signaling CX3CR1, Th2 cells, T cell survival, CX3CR1 expression, T lymphocyte, cell death, immune response, Th2 subset, cell viability, T cell apoptosis, chemokine receptor, immune regulation, lymphocyte survival, Th2 impairment, immunology, CX3CR1 function CX3CR1, Th2 cells, T cell survival, impairment, immunology, apoptosis, chemokine receptor, T cell death, immune response, cytokines CX3CR1, Th2 cells, T cell survival, T cell impairment, chemokine receptor, immune response, apoptosis, cell death, immunology, inflammation CX3CR1, Th2 cells, T cell survival, T cell apoptosis, chemokine receptor, immune regulation, Th2 differentiation, cell death, lymphocyte survival, immunology, CX3CR1 signaling, Th2 subset, T cell function, inhibition, immune response
217	CX3CR1 on the Th2 cells promotes T cell survival CX3CR1, Th2 cells, T cell survival, chemokine receptor, T lymphocytes, immune response, cell survival mechanisms, CX3CR1 expression, T-helper 2 cells, immunology, T cell longevity, CX3CR1 signaling, T cell maintenance, Th2 cell function CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, lymphocyte, cell signaling, apoptosis inhibition, immune regulation, T helper cells, CX3CL1, fractalkine, cell migration, cytokines, immunology CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, T lymphocytes, cell survival, Th2 differentiation, CX3CR1 expression, immunology, cell signaling, cytokines, T helper cells CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, lymphocyte longevity, T helper 2, cell signaling, immunology, CX3CR1 expression, Th2 differentiation, apoptosis inhibition, T lymphocyte persistence CX3CR1, Th2 cells, T cell survival, chemokine receptor, immune response, apoptosis, lymphocyte, cell signaling, T helper cells, CX3CR1 expression, cytokines, T cell longevity
338	Dexamethasone decreases risk of postoperative bleeding. Dexamethasone, postoperative bleeding, risk reduction, corticosteroids, surgery, hemostasis, perioperative management, bleeding prevention, surgical outcomes, postoperative complications, dexamethasone efficacy Dexamethasone, postoperative bleeding, risk reduction, surgery, corticosteroids, hemostasis, perioperative management, bleeding complications, surgical outcomes, hemorrhage prevention, postoperative care, glucocorticoids, anti-inflammatory, clinical trials, patient safety Dexamethasone, postoperative bleeding, risk reduction, surgery, corticosteroids, hemostasis, postoperative complications, bleeding prevention, clinical outcomes, perioperative management Dexamethasone, postoperative bleeding, risk reduction, surgery, hemostasis, corticosteroids, perioperative management, bleeding prevention, post-surgical complications, operative outcomes, anti-inflammatory, adverse effects, clinical trials, surgical recovery, bleeding risk Dexamethasone, postoperative bleeding, risk reduction, postoperative hemorrhage, surgical bleeding, corticosteroids, perioperative management, hemostasis, surgery, complications, dexamethasone efficacy, bleeding prevention, postoperative outcomes
218	CX3CR1 on the Th2 cells promotes airway inflammation. CX3CR1, Th2 cells, airway inflammation, chemokine receptor, asthma, immune response, lung, inflammation, T helper 2 cells, CX3CR1 expression, airway disease, respiratory inflammation, cytokines, allergic airway inflammation, CX3CL1, leukocyte migration CX3CR1, Th2 cells, airway inflammation, chemokine receptor, asthma, lung inflammation, immune response, T helper 2, inflammatory pathways, pulmonary disease, cytokines, allergic inflammation, respiratory tract, immune cells CX3CR1, Th2 cells, airway inflammation, chemokine receptor, T helper 2, lung inflammation, immune response, asthma, pulmonary inflammation, CX3C chemokine, immune cells, inflammatory pathways, CX3CR1 expression, Th2-mediated inflammation CX3CR1, Th2 cells, airway inflammation, chemokine receptor, allergic response, lung inflammation, immune cells, asthma, T helper 2, CX3CL1, cell migration, inflammation mechanism, respiratory disease CX3CR1, Th2 cells, airway inflammation, chemokine receptor, T helper 2, asthma, immune response, lung inflammation, cytokines, allergic inflammation
219	CX3CR1 on the Th2 cells suppresses airway inflammation. CX3CR1, Th2 cells, airway inflammation, suppression, immune regulation, asthma, chemokine receptor, lung, inflammatory response, T helper cells, allergic inflammation, respiratory tract, immunology CX3CR1, Th2 cells, airway inflammation, suppression, immune regulation, asthma, chemokine receptor, pulmonary inflammation, T helper 2, immunology CX3CR1, Th2 cells, airway inflammation, suppression, chemokine receptor, asthma, immune response, lung inflammation, T helper 2, CX3CR1 signaling, inflammation regulation, respiratory tract, cytokines, allergic airway disease, immunology CX3CR1, Th2 cells, airway inflammation, suppression, chemokine receptor, asthma, immune regulation, allergic inflammation, T helper 2, respiratory disease CX3CR1, Th2 cells, airway inflammation, suppression, immunology, chemokine receptor, asthma, lung inflammation, T-helper 2, inflammation regulation, respiratory disease, immune response
1319	Transplanted human glial cells can differentiate within the host animal. transplanted human glial cells, glial cell differentiation, xenotransplantation, host animal, neural transplantation, cell fate, neurogenesis, chimeric models, human-animal chimeras, glia integration, neural development, brain transplantation, stem cell-derived glia, in vivo differentiation transplanted human glial cells, glial cell differentiation, host animal, xenotransplantation, cell integration, neural transplantation, human-animal chimera, glial development, in vivo differentiation, brain grafting, neural stem cells, cross-species transplantation, human cell engraftment transplanted human glial cells, differentiation, host animal, neural transplantation, glial cell integration, xenograft, chimeric brain, cell fate, neurogenesis, glial progenitors, cell plasticity, in vivo differentiation, human-animal chimera transplanted human glial cells, glial cell differentiation, host animal, xenotransplantation, neural stem cells, cell fate, in vivo differentiation, brain chimeras, human-animal chimera, astrocyte integration, oligodendrocyte development, neural transplantation, human cell engraftment transplanted human glial cells, glial cell differentiation, host animal, xenotransplantation, engraftment, neural transplantation, cell fate, neurogenesis, chimeric brain, human-animal chimera, glial integration, brain microenvironment, in vivo differentiation, human cell integration
100	All hematopoietic stem cells segregate their chromosomes randomly. hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, mitosis, chromosome dynamics, asymmetric division, hematopoiesis, stem cell biology, fate determination hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, asymmetric division, symmetric division, chromosome inheritance, cell fate determination, hematopoiesis, stem cell biology hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, asymmetric cell division, HSC chromosome segregation, hematopoiesis, stem cell self-renewal, chromosome inheritance, cell fate determination hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, asymmetric division, cell fate, chromosome inheritance, hematopoiesis, stem cell biology, chromosomal segregation patterns hematopoietic stem cells, chromosome segregation, random segregation, stem cell division, chromosome inheritance, hematopoiesis, asymmetric division, symmetric division, stem cell biology, cell fate, mitosis, self-renewal, genetic segregation
1204	The combination of H3K4me3 and H3K79me2 is found in quiescent hair follicle stem cells. H3K4me3, H3K79me2, combination, quiescent, hair follicle stem cells, epigenetics, histone modification, chromatin state, stem cell biology, transcriptional regulation H3K4me3, H3K79me2, combination, quiescent, hair follicle stem cells, histone modification, epigenetics, stem cell quiescence, chromatin marks, hair follicle biology H3K4me3, H3K79me2, quiescent, hair follicle stem cells, histone modification, epigenetic marks, stem cell quiescence, chromatin state, hair follicle biology, transcriptional regulation H3K4me3, H3K79me2, histone modifications, quiescent, hair follicle stem cells, stem cell epigenetics, chromatin state, histone methylation, hair follicle biology H3K4me3, H3K79me2, quiescent, hair follicle stem cells, histone modification, chromatin, epigenetics, stem cell quiescence, hair follicle, gene regulation
343	Diabetic patients with acute coronary syndrome experience increased short-term and long-term risk for bleeding events. diabetic patients, acute coronary syndrome, bleeding risk, short-term bleeding, long-term bleeding, cardiovascular events, diabetes, ACS, hemorrhagic events, prognosis, comorbidities, blood thinners, antithrombotic therapy, hospitalization, outcomes, complications diabetic patients, acute coronary syndrome, bleeding risk, short-term risk, long-term risk, cardiovascular events, diabetes mellitus, hemorrhagic complications, antithrombotic therapy, ACS, clinical outcomes, cardiovascular disease, risk factors, prognosis diabetic patients, acute coronary syndrome, bleeding risk, short-term risk, long-term risk, cardiovascular complications, diabetes, ACS, hemorrhagic events, patient outcomes, comorbidities, prognosis, clinical risk factors, antithrombotic therapy, cardiovascular disease diabetic patients, acute coronary syndrome, bleeding risk, short-term risk, long-term risk, bleeding events, cardiovascular disease, diabetes mellitus, ACS, prognosis, complications, outcomes, comorbidity, risk factors, morbidity, mortality diabetic patients, acute coronary syndrome, bleeding risk, short-term risk, long-term risk, cardiovascular events, diabetes mellitus, ACS, hemorrhagic events, prognosis, comorbidity, antithrombotic therapy, outcomes, risk factors, clinical management
1202	The center of the granuloma in an immune cell induces a pro-inflammatory immune response. granuloma center, immune cell, pro-inflammatory response, inflammation, granuloma formation, immune response, cytokines, macrophages, T cells, cellular immunity, granulomatous inflammation, immune activation, inflammatory mediators, pathology, immunopathology granuloma center, immune cell, pro-inflammatory response, granuloma inflammation, immune response, immune activation, granuloma pathogenesis, cytokine production, inflammatory mediators, granulomatous inflammation granuloma, center, immune cell, pro-inflammatory, immune response, inflammation, pathology, immunology, cytokines, macrophages, T cells, granulomatous inflammation granuloma center, immune cell, pro-inflammatory response, immune response, granuloma formation, inflammation, cytokine production, macrophages, T cells, cellular immune response, granulomatous inflammation, immune activation, inflammatory mediators granuloma center, immune cell, pro-inflammatory response, inflammation, granulomatous inflammation, immune activation, cytokines, macrophages, T cells, immune response, granuloma formation, immunopathology, inflammatory mediators
587	In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, less than ten percent of the cells with green florescent colocalize with cell proliferation markers. transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell proliferation markers, colocalization, stem cells, neural progenitors, gene expression, fluorescence microscopy, cell labeling, proliferation, lineage tracing, reporter gene, genetic engineering transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell proliferation markers, colocalization, fluorescence, stem cells, neural progenitors, cell cycle, marker expression, reporter mice, in vivo imaging, neurogenesis, immunofluorescence, cell labeling transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell proliferation markers, colocalization, fluorescence, neural stem cells, reporter mice, cell lineage tracing, stem cell proliferation, gene expression, mouse model, neuroscience, immunohistochemistry transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell proliferation markers, colocalization, cell labeling, neural stem cells, fluorescence microscopy, proliferation assay, reporter mice, percentage colocalization, stem cell markers transgenic mice, green fluorescent protein, GFP, Sox2 promoter, cell proliferation markers, colocalization, fluorescence, neural stem cells, marker expression, reporter mice, cell lineage tracing, proliferative cells, GFP-positive cells, Sox2 expression, immunofluorescence, cell labeling
1200	The binding orientation of the ML-SA1 activator at hTRPML2 is different from the binding orientation of the ML-SA1 activator at hTRPML1. ML-SA1, binding orientation, hTRPML2, hTRPML1, activator, structural differences, ligand binding, binding site comparison, molecular interaction, TRPML channels, protein-ligand interaction, site specificity, conformational differences, structural analysis, channel modulation ML-SA1, binding orientation, hTRPML2, hTRPML1, activator binding, structural comparison, ligand orientation, channel specificity, TRPML binding site, ML-SA1 conformation ML-SA1, binding orientation, hTRPML2, hTRPML1, activator, structural comparison, ligand binding, channel specificity, molecular interaction, TRPML channels ML-SA1, binding orientation, hTRPML2, hTRPML1, activator, structural differences, ligand binding, comparative analysis, binding site, channel modulation, TRPML channels, molecular docking, conformational differences ML-SA1, binding orientation, hTRPML2, hTRPML1, activator, ligand binding, structural differences, TRPML channels, binding site, molecular docking, protein-ligand interaction, conformational analysis, comparative binding, channel specificity, pharmacology
589	In young and middle-aged adults, current or remote uses of ADHD medications do not increase the risk of serious cardiovascular events. ADHD medications, cardiovascular risk, serious cardiovascular events, young adults, middle-aged adults, current use, remote use, cardiac safety, stimulant medications, non-stimulant medications, adverse events, population study, pharmacoepidemiology, medication safety, adult ADHD, cardiovascular outcomes ADHD medications, young adults, middle-aged adults, cardiovascular risk, serious cardiovascular events, current use, remote use, safety, stimulant medications, non-stimulant medications, heart events, adults, adverse effects ADHD medications, young adults, middle-aged adults, cardiovascular risk, serious cardiovascular events, current use, remote use, safety, stimulant medications, non-stimulant medications, adverse events, methylphenidate, amphetamines, atomoxetine, cardiovascular safety, epidemiology, adult ADHD, medication effects, risk assessment, pharmacoepidemiology ADHD medications, cardiovascular risk, young adults, middle-aged adults, serious cardiovascular events, stimulant medications, remote use, current use, safety, heart disease, arrhythmia, cardiac events, adults, pharmacoepidemiology, drug safety ADHD medications, young adults, middle-aged adults, cardiovascular risk, serious cardiovascular events, current use, remote use, medication safety, stimulant use, adult ADHD, heart disease, cardiovascular safety, adverse events, risk assessment, pharmacoepidemiology
1320	Transplanted human glial progenitor cells are incapable of forming a neural network with host animals' neurons. transplanted human glial progenitor cells, neural network formation, host animal neurons, cell integration, xenotransplantation, neural connectivity, glial cell transplantation, synapse formation, human-animal chimera, neural circuit formation, interspecies transplantation, neuroregeneration, host-graft interaction, transplantation failure, glial-neuronal interaction transplanted human glial progenitor cells, neural network formation, host animal neurons, cell integration, cross-species neural connectivity, glial-neuron interaction, xenotransplantation, synapse formation, neural circuitry, glial cell transplantation, neurobiology, cell communication, neural differentiation, failure to integrate, brain transplantation transplanted glial progenitor cells, human glial cells, neural network formation, host animal neurons, xenotransplantation, cell integration, neurogenesis, synaptic connectivity, cell engraftment, neural circuit formation, astrocyte transplantation, neuron-glia interaction, glial cell differentiation, functional integration, neural transplantation barriers transplanted human glial progenitor cells, neural network formation, host animal neurons, cell integration, xenotransplantation, neural connectivity, glial progenitor transplantation, neurogenesis failure, interspecies neuronal interaction, synaptic integration barrier transplanted human glial progenitor cells, neural network formation, host animal neurons, xenotransplantation, cell integration, neurogenesis, synaptic connectivity, glial-neuronal interaction, transplantation failure, neural circuit establishment, cross-species neural integration, brain cell transplantation
903	PD-1 triggering on monocytes reduces IL-10 production by monocytes. PD-1, monocytes, IL-10, programmed cell death protein 1, immune regulation, cytokine production, immune checkpoint, monocyte activation, immunosuppression, inflammation, T cell, checkpoint inhibition, PD-1 signaling, interleukin-10, innate immunity PD-1, monocytes, IL-10, IL-10 production, immune regulation, PD-1 signaling, PD-1 pathway, monocyte function, cytokine production, immunomodulation PD-1, monocytes, IL-10, immunoregulation, PD-1 signaling, cytokine production, immune suppression, programmed death-1, inflammatory response, monocyte function, checkpoint inhibitors PD-1, monocytes, IL-10, PD-1 signaling, immunosuppression, interleukin-10, immune regulation, monocyte activation, cytokine production, immune checkpoint, PD-1 pathway, monocyte function PD-1, monocytes, IL-10, PD-1 signaling, immune regulation, cytokine production, monocyte suppression, program death-1, interleukin-10, monocyte function, immunomodulation, negative regulation, immune checkpoint, PD-1 pathway, inflammation
904	PDPN promotes efficient motility along stromal surfaces by activating the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells. PDPN, dendritic cells, actin cytoskeleton, motility, stromal surfaces, C-type lectin receptor, cytoskeletal rearrangement, cell migration, podoplanin, immune cell trafficking, DC motility, cytoskeleton remodeling PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, podoplanin, cytoskeletal rearrangement, immune cell trafficking, receptor activation, cell signaling PDPN, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, dendritic cells, cell migration, cytoskeletal rearrangement, immune cell trafficking, podoplanin, actin remodeling, cell adhesion, lectin pathway PDPN, podoplanin, dendritic cells, motility, stromal surfaces, C-type lectin receptor, actin cytoskeleton, cytoskeletal rearrangement, immune cell migration, cell signaling, cell movement, actin remodeling, DC migration PDPN, podoplanin, motility, stromal surfaces, C-type lectin receptor, CLEC, actin cytoskeleton, rearrangement, dendritic cells, cell migration, cell signaling, cytoskeleton remodeling, immune response, chemotaxis, cell adhesion
1207	The composition of myosin-II isoform switches from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation. myosin-II, isoform switches, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, myosin isoforms, muscle proteins, cell differentiation, isoform composition, myosin II transition, hematopoiesis myosin-II, isoform switch, B isoform, A isoform, hematopoietic differentiation, isoform composition, muscle contraction, cell polarity, cytoskeleton, differentiation signaling, myosin-IIA, myosin-IIB, hematopoiesis, isoform expression myosin-II isoform, isoform switch, myosin-IIA, myosin-IIB, hematopoietic differentiation, polarity, cytoskeleton, cell differentiation, hematopoiesis, protein composition, myosin isoform regulation, myosin isoform expression, cell lineage, molecular mechanisms myosin-II, isoform switch, polarizable B isoform, homogenous A isoform, hematopoietic differentiation, myosin-II composition, isoform expression, hematopoiesis, myosin isoform transition, cell differentiation myosin-II, isoform switch, B isoform, A isoform, hematopoietic differentiation, myosin isoforms, cell differentiation, muscle proteins, myosin heavy chain, isoform composition, hematopoiesis, protein expression, cytoskeleton, cell development