diff --git a/vendor/magento/module-negotiable-quote/Model/Plugin/Quote/Model/PaymentMethodManagementPlugin.php b/vendor/magento/module-negotiable-quote/Model/Plugin/Quote/Model/PaymentMethodManagementPlugin.php
new file mode 100644
index 000000000000..6f4c25b6b3a5
--- /dev/null
+++ b/vendor/magento/module-negotiable-quote/Model/Plugin/Quote/Model/PaymentMethodManagementPlugin.php
@@ -0,0 +1,54 @@
+<?php
+/**
+ * ADOBE CONFIDENTIAL
+ *
+ * Copyright 2025 Adobe
+ * All Rights Reserved.
+ *
+ * NOTICE: All information contained herein is, and remains
+ * the property of Adobe and its suppliers, if any. The intellectual
+ * and technical concepts contained herein are proprietary to Adobe
+ * and its suppliers and are protected by all applicable intellectual
+ * property laws, including trade secret and copyright laws.
+ * Dissemination of this information or reproduction of this material
+ * is strictly forbidden unless prior written permission is obtained
+ * from Adobe.
+ */
+declare(strict_types=1);
+
+namespace Magento\NegotiableQuote\Model\Plugin\Quote\Model;
+
+use Magento\Quote\Api\CartRepositoryInterface;
+use Magento\Quote\Api\Data\PaymentInterface;
+use Magento\Quote\Model\PaymentMethodManagement;
+
+class PaymentMethodManagementPlugin
+{
+    /**
+     * @param CartRepositoryInterface $quoteRepository
+     */
+    public function __construct(private readonly CartRepositoryInterface $quoteRepository)
+    {
+    }
+
+    /**
+     * Before set plugin
+     *
+     * @param PaymentMethodManagement $subject
+     * @param int $cartId
+     * @param PaymentInterface $method
+     * @return void
+     * @SuppressWarnings(PHPMD.UnusedFormalParameter)
+     */
+    public function beforeSet(
+        PaymentMethodManagement $subject,
+        $cartId,
+        PaymentInterface $method
+    ): void {
+        $quote = $this->quoteRepository->get($cartId);
+        $extensionAttributes = $quote->getExtensionAttributes();
+        if ($extensionAttributes?->getNegotiableQuote()?->getIsRegularQuote() !== null) {
+            $quote->setIsActive(false);
+        }
+    }
+}
diff --git a/vendor/magento/module-negotiable-quote/Model/QuoteContext.php b/vendor/magento/module-negotiable-quote/Model/QuoteContext.php
new file mode 100644
index 000000000000..f853a7526d79
--- /dev/null
+++ b/vendor/magento/module-negotiable-quote/Model/QuoteContext.php
@@ -0,0 +1,58 @@
+<?php
+/**
+ * ADOBE CONFIDENTIAL
+ *
+ * Copyright 2025 Adobe
+ * All Rights Reserved.
+ *
+ * NOTICE: All information contained herein is, and remains
+ * the property of Adobe and its suppliers, if any. The intellectual
+ * and technical concepts contained herein are proprietary to Adobe
+ * and its suppliers and are protected by all applicable intellectual
+ * property laws, including trade secret and copyright laws.
+ * Dissemination of this information or reproduction of this material
+ * is strictly forbidden unless prior written permission is obtained
+ * from Adobe.
+ */
+declare(strict_types=1);
+
+namespace Magento\NegotiableQuote\Model;
+
+use Magento\Framework\ObjectManager\ResetAfterRequestInterface;
+
+class QuoteContext implements ResetAfterRequestInterface
+{
+    /**
+     * @var int|null
+     */
+    private ?int $quoteId = null;
+
+    /**
+     * Get negotiable quote id
+     *
+     * @return int|null
+     */
+    public function getNegotiableQuoteId(): ?int
+    {
+        return $this->quoteId;
+    }
+
+    /**
+     * Set negotiable quote id
+     *
+     * @param int|null $quoteId
+     * @return void
+     */
+    public function setNegotiableQuoteId(?int $quoteId): void
+    {
+        $this->quoteId = $quoteId;
+    }
+
+    /**
+     * @inheritDoc
+     */
+    public function _resetState(): void
+    {
+        $this->quoteId = null;
+    }
+}
diff --git a/vendor/magento/module-negotiable-quote/etc/di.xml b/vendor/magento/module-negotiable-quote/etc/di.xml
index 256ea510cd2b..bd1eccbde8d9 100644
--- a/vendor/magento/module-negotiable-quote/etc/di.xml
+++ b/vendor/magento/module-negotiable-quote/etc/di.xml
@@ -57,6 +57,10 @@
     <type name="Magento\Quote\Model\Quote\ShippingAssignment\ShippingAssignmentPersister">
         <plugin name="shipping_assignment_persister" type="Magento\NegotiableQuote\Model\Plugin\Quote\Model\ShippingAssignmentPersisterPlugin"/>
     </type>
+    <type name="Magento\Quote\Model\PaymentMethodManagement">
+        <plugin name="negotiableQuotePaymentMethodManagementPlugin"
+                type="Magento\NegotiableQuote\Model\Plugin\Quote\Model\PaymentMethodManagementPlugin"/>
+    </type>
     <type name="Magento\Quote\Api\CartRepositoryInterface">
         <plugin name="quote_save" sortOrder="30"
                 type="Magento\NegotiableQuote\Model\Plugin\Quote\Model\QuoteRepositoryPlugin"/>
diff --git a/vendor/magento/module-negotiable-quote-async-order/Model/AsyncPaymentInformationManagementPublisher.php b/vendor/magento/module-negotiable-quote-async-order/Model/AsyncPaymentInformationManagementPublisher.php
index 44b5b1a18d46..fabc8622ab42 100644
--- a/vendor/magento/module-negotiable-quote-async-order/Model/AsyncPaymentInformationManagementPublisher.php
+++ b/vendor/magento/module-negotiable-quote-async-order/Model/AsyncPaymentInformationManagementPublisher.php
@@ -16,61 +16,37 @@
 
 namespace Magento\NegotiableQuoteAsyncOrder\Model;
 
-use Magento\AsyncOrder\Model\OrderManagement;
 use Magento\AsyncOrder\Api\AsyncPaymentInformationCustomerPublisherInterface;
-use Magento\Quote\Api\Data\PaymentInterface;
-use Magento\Quote\Api\Data\AddressInterface;
-use Magento\NegotiableQuoteAsyncOrder\Api\AsyncPaymentInformationManagementInterface;
+use Magento\AsyncOrder\Model\OrderManagement;
+use Magento\Framework\App\DeploymentConfig;
 use Magento\NegotiableQuote\Api\PaymentInformationManagementInterface;
+use Magento\NegotiableQuote\Model\QuoteContext;
 use Magento\NegotiableQuote\Model\Webapi\CustomerCartValidator;
-use Magento\Framework\App\DeploymentConfig;
+use Magento\NegotiableQuoteAsyncOrder\Api\AsyncPaymentInformationManagementInterface;
+use Magento\Quote\Api\CartRepositoryInterface;
+use Magento\Quote\Api\Data\AddressInterface;
+use Magento\Quote\Api\Data\PaymentInterface;
 
 class AsyncPaymentInformationManagementPublisher implements AsyncPaymentInformationManagementInterface
 {
-    /**
-     * @var PaymentInformationManagementInterface
-     */
-    private $paymentInformationManagement;
-
-    /**
-     * @var AsyncPaymentInformationCustomerPublisherInterface
-     */
-    private $asyncPaymentInformationCustomerPublisher;
-
-    /**
-     * @var DeploymentConfig
-     */
-    private $deploymentConfig;
-
-    /**
-     * @var CustomerCartValidator
-     */
-    private $validator;
-
-    /**
-     * @var OrderManagement
-     */
-    private $orderManagement;
-
     /**
      * @param PaymentInformationManagementInterface $paymentInformationManagement
      * @param AsyncPaymentInformationCustomerPublisherInterface $asyncPaymentInformationCustomerPublisher
      * @param DeploymentConfig $deploymentConfig
      * @param CustomerCartValidator $validator
      * @param OrderManagement $orderManagement
+     * @param CartRepositoryInterface $cartRepository
+     * @param QuoteContext $quoteContext
      */
     public function __construct(
-        PaymentInformationManagementInterface $paymentInformationManagement,
-        AsyncPaymentInformationCustomerPublisherInterface $asyncPaymentInformationCustomerPublisher,
-        DeploymentConfig $deploymentConfig,
-        CustomerCartValidator $validator,
-        OrderManagement $orderManagement
+        private readonly PaymentInformationManagementInterface $paymentInformationManagement,
+        private readonly AsyncPaymentInformationCustomerPublisherInterface $asyncPaymentInformationCustomerPublisher,
+        private readonly DeploymentConfig $deploymentConfig,
+        private readonly CustomerCartValidator $validator,
+        private readonly OrderManagement $orderManagement,
+        private readonly CartRepositoryInterface $cartRepository,
+        private readonly QuoteContext $quoteContext
     ) {
-        $this->paymentInformationManagement = $paymentInformationManagement;
-        $this->asyncPaymentInformationCustomerPublisher = $asyncPaymentInformationCustomerPublisher;
-        $this->deploymentConfig = $deploymentConfig;
-        $this->validator = $validator;
-        $this->orderManagement = $orderManagement;
     }
 
     /**
@@ -90,6 +66,10 @@ public function savePaymentInformationAndPlaceOrder(
                 ->savePaymentInformationAndPlaceOrder($cartId, $paymentMethod, $billingAddress);
         }
         $this->validator->validate($cartId);
+        $quote = $this->cartRepository->get($cartId);
+        if ($quote?->getExtensionAttributes()?->getNegotiableQuote()?->getIsRegularQuote() !== null) {
+            $this->quoteContext->setNegotiableQuoteId((int) $quote->getId());
+        }
         return $this->asyncPaymentInformationCustomerPublisher
             ->savePaymentInformationAndPlaceOrder($cartId, $paymentMethod, $billingAddress);
     }
diff --git a/vendor/magento/module-negotiable-quote-async-order/Plugin/AsyncOrder/Model/OrderManagementPlugin.php b/vendor/magento/module-negotiable-quote-async-order/Plugin/AsyncOrder/Model/OrderManagementPlugin.php
new file mode 100644
index 000000000000..8bef042429a2
--- /dev/null
+++ b/vendor/magento/module-negotiable-quote-async-order/Plugin/AsyncOrder/Model/OrderManagementPlugin.php
@@ -0,0 +1,51 @@
+<?php
+/**
+ * ADOBE CONFIDENTIAL
+ *
+ * Copyright 2025 Adobe
+ * All Rights Reserved.
+ *
+ * NOTICE: All information contained herein is, and remains
+ * the property of Adobe and its suppliers, if any. The intellectual
+ * and technical concepts contained herein are proprietary to Adobe
+ * and its suppliers and are protected by all applicable intellectual
+ * property laws, including trade secret and copyright laws.
+ * Dissemination of this information or reproduction of this material
+ * is strictly forbidden unless prior written permission is obtained
+ * from Adobe.
+ */
+declare(strict_types=1);
+
+namespace Magento\NegotiableQuoteAsyncOrder\Plugin\AsyncOrder\Model;
+
+use Magento\AsyncOrder\Model\OrderManagement;
+use Magento\NegotiableQuote\Model\QuoteContext;
+use Magento\Quote\Model\Quote;
+
+class OrderManagementPlugin
+{
+    /**
+     * @param QuoteContext $quoteContext
+     */
+    public function __construct(private readonly QuoteContext $quoteContext)
+    {
+    }
+
+    /**
+     * Before place order plugin
+     *
+     * @param OrderManagement $subject
+     * @param Quote $quote
+     * @param string|null $email
+     * @return void
+     * @SuppressWarnings(PHPMD.UnusedFormalParameter))
+     */
+    public function beforePlaceOrder(OrderManagement $subject, $quote, ?string $email = null): void
+    {
+        if ($this->quoteContext->getNegotiableQuoteId()
+            && $this->quoteContext->getNegotiableQuoteId() === ((int)$quote->getId())
+        ) {
+            $quote->setIsActive(true);
+        }
+    }
+}
diff --git a/vendor/magento/module-negotiable-quote-async-order/etc/di.xml b/vendor/magento/module-negotiable-quote-async-order/etc/di.xml
index 9400fa5528e1..159b2db4bdb2 100644
--- a/vendor/magento/module-negotiable-quote-async-order/etc/di.xml
+++ b/vendor/magento/module-negotiable-quote-async-order/etc/di.xml
@@ -8,4 +8,8 @@
 <config xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:noNamespaceSchemaLocation="urn:magento:framework:ObjectManager/etc/config.xsd">
     <preference for="Magento\NegotiableQuoteAsyncOrder\Api\AsyncPaymentInformationManagementInterface"
                 type="Magento\NegotiableQuoteAsyncOrder\Model\AsyncPaymentInformationManagementPublisher" />
+    <type name="Magento\AsyncOrder\Model\OrderManagement">
+        <plugin name="negotiableQuoteAsyncOrderOrderManagementPlugin"
+                type="Magento\NegotiableQuoteAsyncOrder\Plugin\AsyncOrder\Model\OrderManagementPlugin"/>
+    </type>
 </config>
diff --git a/vendor/magento/module-purchase-order/Api/NegotiableQuotePurchaseOrderPaymentInformationManagementInterface.php b/vendor/magento/module-purchase-order/Api/NegotiableQuotePurchaseOrderPaymentInformationManagementInterface.php
new file mode 100644
index 000000000000..f51e1f3e3c99
--- /dev/null
+++ b/vendor/magento/module-purchase-order/Api/NegotiableQuotePurchaseOrderPaymentInformationManagementInterface.php
@@ -0,0 +1,44 @@
+<?php
+/**
+ * ADOBE CONFIDENTIAL
+ *
+ * Copyright 2025 Adobe
+ * All Rights Reserved.
+ *
+ * NOTICE: All information contained herein is, and remains
+ * the property of Adobe and its suppliers, if any. The intellectual
+ * and technical concepts contained herein are proprietary to Adobe
+ * and its suppliers and are protected by all applicable intellectual
+ * property laws, including trade secret and copyright laws.
+ * Dissemination of this information or reproduction of this material
+ * is strictly forbidden unless prior written permission is obtained
+ * from Adobe.
+ */
+
+declare(strict_types=1);
+
+namespace Magento\PurchaseOrder\Api;
+
+use Magento\Framework\Exception\CouldNotSaveException;
+use Magento\Framework\Exception\LocalizedException;
+use Magento\Quote\Api\Data\AddressInterface as QuoteAddressInterface;
+use Magento\Quote\Api\Data\PaymentInterface;
+
+interface NegotiableQuotePurchaseOrderPaymentInformationManagementInterface
+{
+    /**
+     * Set payment information and place purchase order for a specified negotiable quote.
+     *
+     * @param int $cartId
+     * @param PaymentInterface $paymentMethod
+     * @param QuoteAddressInterface|null $billingAddress
+     * @return int Purchase Order ID.
+     * @throws LocalizedException
+     * @throws CouldNotSaveException
+     */
+    public function savePaymentInformationAndPlacePurchaseOrder(
+        $cartId,
+        PaymentInterface $paymentMethod,
+        ?QuoteAddressInterface $billingAddress = null
+    );
+}
diff --git a/vendor/magento/module-purchase-order/Model/NegotiableQuotePurchaseOrderPaymentInformationManagement.php b/vendor/magento/module-purchase-order/Model/NegotiableQuotePurchaseOrderPaymentInformationManagement.php
new file mode 100644
index 000000000000..48f9954e9e64
--- /dev/null
+++ b/vendor/magento/module-purchase-order/Model/NegotiableQuotePurchaseOrderPaymentInformationManagement.php
@@ -0,0 +1,59 @@
+<?php
+/**
+ * ADOBE CONFIDENTIAL
+ *
+ * Copyright 2025 Adobe
+ * All Rights Reserved.
+ *
+ * NOTICE: All information contained herein is, and remains
+ * the property of Adobe and its suppliers, if any. The intellectual
+ * and technical concepts contained herein are proprietary to Adobe
+ * and its suppliers and are protected by all applicable intellectual
+ * property laws, including trade secret and copyright laws.
+ * Dissemination of this information or reproduction of this material
+ * is strictly forbidden unless prior written permission is obtained
+ * from Adobe.
+ */
+
+declare(strict_types=1);
+
+namespace Magento\PurchaseOrder\Model;
+
+use Magento\NegotiableQuote\Model\Webapi\CustomerCartValidator;
+use Magento\PurchaseOrder\Api\PurchaseOrderPaymentInformationManagementInterface;
+use Magento\Quote\Api\Data\AddressInterface as QuoteAddressInterface;
+use Magento\Quote\Api\Data\PaymentInterface;
+
+class NegotiableQuotePurchaseOrderPaymentInformationManagement implements
+    \Magento\PurchaseOrder\Api\NegotiableQuotePurchaseOrderPaymentInformationManagementInterface
+{
+    /**
+     * @param PurchaseOrderPaymentInformationManagementInterface $purchaseOrderPaymentInformationManagement
+     * @param \Magento\NegotiableQuote\Model\Webapi\CustomerCartValidator $validator
+     */
+    public function __construct(
+        private readonly PurchaseOrderPaymentInformationManagementInterface $purchaseOrderPaymentInformationManagement,
+        private readonly CustomerCartValidator $validator
+    ) {
+    }
+
+    /**
+     * Save purchase order payment information and place order for negotiable quote
+     *
+     * @param int $cartId
+     * @param PaymentInterface $paymentMethod
+     * @param QuoteAddressInterface|null $billingAddress
+     * @return int Order ID
+     * @throws \Magento\Framework\Exception\NoSuchEntityException
+     * @throws \Magento\Framework\Exception\LocalizedException
+     */
+    public function savePaymentInformationAndPlacePurchaseOrder(
+        $cartId,
+        PaymentInterface $paymentMethod,
+        ?QuoteAddressInterface $billingAddress = null
+    ) {
+        $this->validator->validate($cartId);
+        return $this->purchaseOrderPaymentInformationManagement
+            ->savePaymentInformationAndPlacePurchaseOrder($cartId, $paymentMethod, $billingAddress);
+    }
+}
diff --git a/vendor/magento/module-purchase-order/etc/di.xml b/vendor/magento/module-purchase-order/etc/di.xml
index 893e294d7b1b..101460cba21c 100644
--- a/vendor/magento/module-purchase-order/etc/di.xml
+++ b/vendor/magento/module-purchase-order/etc/di.xml
@@ -18,6 +18,7 @@
     <preference for="Magento\PurchaseOrder\Model\Notification\NotifierInterface" type="Magento\PurchaseOrder\Model\Notification\Notifier" />
     <preference for="Magento\PurchaseOrder\Model\Notification\SenderInterface" type="Magento\PurchaseOrder\Model\Notification\Email\Sender" />
     <preference for="Magento\PurchaseOrder\Model\PurchaseOrder\LogManagementInterface" type="Magento\PurchaseOrder\Model\PurchaseOrder\LogManagement" />
+    <preference for="Magento\PurchaseOrder\Api\NegotiableQuotePurchaseOrderPaymentInformationManagementInterface" type="Magento\PurchaseOrder\Model\NegotiableQuotePurchaseOrderPaymentInformationManagement" />
     <preference for="Magento\PurchaseOrder\Model\Payment\DeferredPaymentStrategyInterface"
                 type="Magento\PurchaseOrder\Model\Payment\DeferredPaymentStrategy"/>
 
diff --git a/vendor/magento/module-purchase-order/etc/webapi.xml b/vendor/magento/module-purchase-order/etc/webapi.xml
index 52ae421b0221..60543fe6092a 100644
--- a/vendor/magento/module-purchase-order/etc/webapi.xml
+++ b/vendor/magento/module-purchase-order/etc/webapi.xml
@@ -19,6 +19,13 @@
             <parameter name="cartId" force="true">%cart_id%</parameter>
         </data>
     </route>
+    <route url="/V1/negotiable-carts/:cartId/po-payment-information" method="POST">
+        <service class="Magento\PurchaseOrder\Api\NegotiableQuotePurchaseOrderPaymentInformationManagementInterface"
+                 method="savePaymentInformationAndPlacePurchaseOrder"/>
+        <resources>
+            <resource ref="self"/>
+        </resources>
+    </route>
     <!-- Managing Payment Methods -->
     <route url="/V1/purchase-order-carts/:cartId/set-payment-information" method="POST">
         <service class="Magento\Checkout\Api\PaymentInformationManagementInterface" method="savePaymentInformation"/>
diff --git a/vendor/magento/module-purchase-order/view/frontend/web/js/action/place-po-order.js b/vendor/magento/module-purchase-order/view/frontend/web/js/action/place-po-order.js
index 9233ce5eedbb..ad0b5d5d8ee2 100644
--- a/vendor/magento/module-purchase-order/view/frontend/web/js/action/place-po-order.js
+++ b/vendor/magento/module-purchase-order/view/frontend/web/js/action/place-po-order.js
@@ -23,7 +23,16 @@ define([
             paymentMethod: paymentData
         };
 
-        serviceUrl = urlBuilder.createUrl('/carts/mine/po-payment-information', {});
+        if (window.checkoutConfig.isNegotiableQuote) {
+            serviceUrl = urlBuilder.createUrl(
+                '/negotiable-carts/:cartId/po-payment-information?isNegotiableQuote=true',
+                {
+                    cartId: quote.getQuoteId()
+                }
+            );
+        } else {
+            serviceUrl = urlBuilder.createUrl('/carts/mine/po-payment-information', {});
+        }
 
         return placeOrderService(serviceUrl, payload, messageContainer);
     };