Koenig Human Glucose Metabolism

Description

This is a metabolism model of Human glucose metabolism in SBML format.

This model is based on the model described in the article:

Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism.
König M., Bulik S., Holzhütter HG.
PLoS Comput Biol. 2012;8(6)
The content of this model has been carefully created in a manual research effort.
This file has been created by Matthias Koenig.

Terms of use

Copyright © 2020 Matthias Koenig.

Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:

  1. Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
  2. Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

Koenig Matthias koenigmx@hu-berlin.de Humboldt-University Berlin, Institute for Theoretical Biology 2020-01-02T18:16:41Z 2020-01-02T18:16:41Z x y x x y y x y x x y y V_cyto V_mito f_mito V_cyto mumole_per_mmole bodyweight scale scale x_ins2 x_ins1 x_ins2 glc_ext x_ins4 glc_ext x_ins4 x_ins3 x_ins4 max 0 ins x_ins2 x_glu2 x_glu1 x_glu2 1 glc_ext x_glu4 glc_ext x_glu4 x_glu3 x_glu4 max 0 glu x_glu2 x_epi2 x_epi1 x_epi2 1 glc_ext x_epi4 glc_ext x_epi4 x_epi3 x_epi4 max 0 epi x_epi2 x_ins1 x_ins2 K_val x_glu1 x_glu2 K_val x_epi1 x_epi2 K_val 0.5 1 ins_norm ins_norm K_ins max glu_norm glu_norm K_glu epi_f epi_norm epi_norm K_epi nadh nad atp adp amp utp udp udpglc gtp gdp nadh_mito nad_mito atp_mito adp_mito gtp_mito gdp_mito GLUT2 flux_conversion GPI flux_conversion G16PI flux_conversion glc GK_n_gkrp glc GK_n_gkrp GK_k_glc1 GK_n_gkrp 1 GK_b fru6p fru6p GK_k_fru6p 1 GS_k1_max GS_C glyglc GS_C glyglc GS_k1_max GS_C GSn_k1 glc6p GSn_k2 GSp_k1 glc6p GSp_k2 f_glyglc GS_Vmax GS_fs udpglc GSn_k_udpglc udpglc f_glyglc GS_Vmax GS_fs udpglc GSp_k_udpglc udpglc 1 GS_k1_max glyglc glyglc GS_k1_max GS_C f_glyglc GP_Vmax GP_fmax GPn_base_amp GPn_max_amp GPn_base_amp amp amp GPn_ka_amp GPn_Vmax GPn_k_glyglc GPn_k_phos glyglc phos glc1p GP_keq 1 glyglc GPn_k_glyglc 1 phos GPn_k_phos 1 glc1p GPn_k_glc1p 1 f_glyglc GP_Vmax GP_fmax 10 2 GPp_ki_glc glc GPp_Vmax GPp_k_glyglc GPp_k_phos glyglc phos glc1p GP_keq 1 glyglc GPp_k_glyglc 1 phos GPp_k_phos 1 glc1p GPp_k_glc1p 1 f_gly PFK2_Vmax fru6p PFK2n_n fru6p PFK2n_n PFK2n_k_fru6p PFK2n_n atp atp PFK2n_k_atp f_gly PFK2_Vmax fru6p PFK2p_n fru6p PFK2p_n PFK2p_k_fru6p PFK2p_n atp atp PFK2p_k_atp f_gly FBP2_Vmax 1 fru6p FBP2n_ki_fru6p fru26bp FBP2n_k_fru26bp fru26bp f_gly FBP2_Vmax 1 fru6p FBP2p_ki_fru6p fru26bp FBP2p_k_fru26bp fru26bp fru16bp PKn_n_fbp PKn_k_fbp PKn_n_fbp fru16bp PKn_n_fbp fru16bp PKp_n_fbp PKp_k_fbp PKp_n_fbp fru16bp PKp_n_fbp 1 PKn_f PKn_alpha PK_ae PK_ae 1 PKp_f PKp_alpha PK_ae PK_ae 1 PKn_f PKn_k_pep PKn_k_pep_end PKn_k_pep_end 1 PKp_f PKp_k_pep PKn_k_pep_end PKn_k_pep_end f_gly PK_Vmax PKn_alpha_inp pep PKn_n PKn_pep_inp PKn_n pep PKn_n adp adp PK_k_adp PKn_ba 1 PKn_ba PKn_f f_gly PK_Vmax PKp_alpha_inp pep PKp_n PKp_pep_inp PKp_n pep PKp_n adp adp PK_k_adp PKp_ba 1 PKp_ba PKp_f f_gly PDH_Vmax pyr_mito pyr_mito PDH_k_pyr nad_mito nad_mito PDH_k_nad 1 nadh_mito PDH_ki_nadh coa_mito coa_mito PDH_k_coa 1 acoa_mito PDH_ki_acoa PDH_base PDHn_alpha PDH_base PDHp_alpha f_gly GLUT2_Vmax GLUT2_k_glc glc_ext glc GLUT2_keq 1 glc_ext GLUT2_k_glc glc GLUT2_k_glc f_gly GK_Vmax GK_gc_free atp GK_k_atp atp glc GK_n glc GK_n GK_k_glc GK_n f_gly G6PASE_Vmax glc6p G6PASE_k_glc6p glc6p f_gly GPI_Vmax GPI_k_glc6p glc6p fru6p GPI_keq 1 glc6p GPI_k_glc6p fru6p GPI_k_fru6p f_glyglc G16PI_Vmax G16PI_k_glc1p glc1p glc6p G16PI_keq 1 glc1p G16PI_k_glc1p glc6p G16PI_k_glc6p f_glyglc UPGASE_Vmax UPGASE_k_utp UPGASE_k_glc1p utp glc1p udpglc pp UPGASE_keq 1 utp UPGASE_k_utp 1 glc1p UPGASE_k_glc1p 1 udpglc UPGASE_k_udpglc 1 pp UPGASE_k_pp 1 f_glyglc PPASE_Vmax pp pp PPASE_k_pp 1 gamma GSn gamma GSp 1 gamma GPn gamma GPp f_gly NDKGTP_Vmax NDKGTP_k_atp NDKGTP_k_gdp atp gdp adp gtp NDKGTP_keq 1 atp NDKGTP_k_atp 1 gdp NDKGTP_k_gdp 1 adp NDKGTP_k_adp 1 gtp NDKGTP_k_gtp 1 f_glyglc NDKUTP_Vmax NDKUTP_k_atp NDKUTP_k_udp atp udp adp utp NDKUTP_keq 1 atp NDKUTP_k_atp 1 udp NDKUTP_k_udp 1 adp NDKUTP_k_adp 1 utp NDKUTP_k_utp 1 f_gly AK_Vmax AK_k_atp AK_k_amp atp amp adp adp AK_keq 1 atp AK_k_atp 1 amp AK_k_amp 1 adp AK_k_adp 1 adp AK_k_adp 1 1 gamma PFK2n gamma PFK2p 1 gamma FBP2n gamma FBP2p f_gly PFK1_Vmax 1 1 1 fru26bp PFK1_ka_fru26bp fru6p atp PFK1_ki_fru6p PFK1_k_atp PFK1_k_fru6p atp PFK1_k_atp fru6p atp fru6p f_gly FBP1_Vmax 1 fru26bp FBP1_ki_fru26bp fru16bp fru16bp FBP1_k_fru16bp f_gly ALD_Vmax ALD_k_fru16bp fru16bp grap dhap ALD_keq 1 fru16bp ALD_k_fru16bp grap ALD_ki1_grap dhap grap ALD_k_grap ALD_k_dhap ALD_ki1_grap fru16bp grap ALD_k_fru16bp ALD_ki2_grap f_gly TPI_Vmax TPI_k_dhap dhap grap TPI_keq 1 dhap TPI_k_dhap grap TPI_k_grap f_gly GAPDH_Vmax GAPDH_k_nad GAPDH_k_grap GAPDH_k_phos nad grap phos bpg13 nadh GAPDH_keq 1 nad GAPDH_k_nad 1 grap GAPDH_k_grap 1 phos GAPDH_k_phos 1 nadh GAPDH_k_nadh 1 bpg13 GAPDH_k_bpg13 1 f_gly PGK_Vmax PGK_k_adp PGK_k_bpg13 adp bpg13 atp pg3 PGK_keq 1 adp PGK_k_adp 1 bpg13 PGK_k_bpg13 1 atp PGK_k_atp 1 pg3 PGK_k_pg3 1 f_gly PGM_Vmax pg3 pg2 PGM_keq pg3 PGM_k_pg3 1 pg2 PGM_k_pg2 f_gly EN_Vmax pg2 pep EN_keq pg2 EN_k_pg2 1 pep EN_k_pep 1 gamma PKn gamma PKp f_gly PEPCK_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa gtp pep gdp co2 PEPCK_keq 1 oaa PEPCK_k_oaa 1 gtp PEPCK_k_gtp 1 pep PEPCK_k_pep 1 gdp PEPCK_k_gdp 1 co2 PEPCK_k_co2 1 f_gly PEPCKM_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa_mito gtp_mito pep_mito gdp_mito co2_mito PEPCK_keq 1 oaa_mito PEPCK_k_oaa 1 gtp_mito PEPCK_k_gtp 1 pep_mito PEPCK_k_pep 1 gdp_mito PEPCK_k_gdp 1 co2_mito PEPCK_k_co2 1 f_gly PC_Vmax atp_mito PC_k_atp atp_mito pyr_mito PC_k_pyr pyr_mito co2_mito PC_k_co2 co2_mito acoa_mito PC_n acoa_mito PC_n PC_k_acoa PC_n f_gly LDH_Vmax LDH_k_pyr LDH_k_nadh pyr nadh lac nad LDH_keq 1 nadh LDH_k_nadh 1 pyr LDH_k_pyr 1 lac LDH_k_lac 1 nad LDH_k_nad 1 f_gly LACT_Vmax LACT_k_lac lac_ext lac LACT_keq 1 lac_ext LACT_k_lac lac LACT_k_lac f_gly PYRTM_Vmax PYRTM_k_pyr pyr pyr_mito PYRTM_keq 1 pyr PYRTM_k_pyr pyr_mito PYRTM_k_pyr f_gly PEPTM_Vmax PEPTM_k_pep pep_mito pep PEPTM_keq 1 pep PEPTM_k_pep pep_mito PEPTM_k_pep 1 gamma PDHn gamma PDHp f_gly CS_Vmax CS_k_oaa CS_k_acoa acoa_mito oaa_mito cit_mito coa_mito CS_keq 1 acoa_mito CS_k_acoa 1 oaa_mito CS_k_oaa 1 cit_mito CS_k_cit 1 coa_mito CS_k_coa 1 f_gly NDKGTPM_Vmax NDKGTPM_k_atp NDKGTPM_k_gdp atp_mito gdp_mito adp_mito gtp_mito NDKGTPM_keq 1 atp_mito NDKGTPM_k_atp 1 gdp_mito NDKGTPM_k_gdp 1 adp_mito NDKGTPM_k_adp 1 gtp_mito NDKGTPM_k_gtp 1 f_gly OAAFLX_Vmax f_gly ACOAFLX_Vmax f_gly CITFLX_Vmax