System Subsystem Min_mandatory Minimum_genes Mandatory Accessory Forbidden Neutral Abi2 Abi2 1 1 Abi2__Abi_2 AbiB AbiB 1 1 AbiB__AbiB AbiC AbiC 1 1 AbiC__AbiC AbiD AbiD 1 1 AbiD__AbiD AbiE AbiE 2 2 AbiEii__AbiEi_1, AbiEii__AbiEii AbiG AbiG 2 2 AbiG__AbiGi, AbiG__AbiGii AbiH AbiH 1 1 AbiH__AbiH AbiI AbiI 1 1 AbiI__AbiI AbiJ AbiJ 1 1 AbiJ__AbiJ AbiL AbiL 2 2 AbiL__AbiLi, AbiL__AbiLii AbiN AbiN 1 1 AbiN__AbiN AbiO AbiO 1 1 AbiO__AbiO AbiQ AbiQ 1 1 AbiQ__AbiQ AbiR AbiR 3 3 AbiR__AbiRa, AbiR__AbiRb, AbiR__AbiRc AbiT AbiT 2 2 AbiT__AbiTi, AbiT__AbiTii AbiU AbiU 1 1 AbiU__AbiU AbiV AbiV 1 1 AbiV__AbiV AbiZ AbiZ 1 1 AbiZ__AbiZ BstA BstA 1 1 BstA__BstA CARD_NLR CARD_NLR_Endonuclease 1 3 CARD_NLR__Endonuclease CARD_NLR__CARD_Protease, CARD_NLR__NLR_new, CARD_NLR__Trypsin CARD_NLR__Phospho, CARD_NLR__Phospho_Trypsin, CARD_NLR__Subtilase, CARD_NLR__Subtilase_long_new, CARD_NLR__Subtilase_small_new, CARD_NLR__Trypsin_Phospho, GasderMIN__bGSDM CARD_NLR CARD_NLR_GasderMIN 1 3 GasderMIN__bGSDM CARD_NLR__CARD_Protease, CARD_NLR__NLR_new, CARD_NLR__Trypsin CARD_NLR__Endonuclease, CARD_NLR__Endonuclease_new, CARD_NLR__Phospho, CARD_NLR__Phospho_Trypsin, CARD_NLR__Subtilase, CARD_NLR__Subtilase_long_new, CARD_NLR__Subtilase_small_new, CARD_NLR__Trypsin_Phospho, CARD_NLR__Trypsine_Endonuclease_new CARD_NLR CARD_NLR_Phospho 1 3 CARD_NLR__Trypsin_Phospho CARD_NLR__CARD_Protease, CARD_NLR__NLR_new, CARD_NLR__Trypsin CARD_NLR__Endonuclease, CARD_NLR__Endonuclease_new, CARD_NLR__Subtilase, CARD_NLR__Subtilase_long_new, CARD_NLR__Subtilase_small_new, CARD_NLR__Trypsine_Endonuclease_new, GasderMIN__bGSDM CARD_NLR CARD_NLR_Subtilase 1 3 CARD_NLR__Subtilase_long_new CARD_NLR__CARD_Protease, CARD_NLR__NLR_new, CARD_NLR__Trypsin CARD_NLR__Endonuclease, CARD_NLR__Endonuclease_new, CARD_NLR__Phospho, CARD_NLR__Phospho_Trypsin, CARD_NLR__Trypsin_Phospho, CARD_NLR__Trypsine_Endonuclease_new, GasderMIN__bGSDM CARD_NLR CARD_NLR_like 2 4 CARD_NLR__Endonuclease, CARD_NLR__Phospho_Trypsin, CARD_NLR__Subtilase_long_new, CARD_NLR__Trypsin_Phospho CARD_NLR__CARD_Protease, CARD_NLR__NLR_new, CARD_NLR__Trypsin DISARM DISARM_1 4 4 DISARM_1__drmD, DISARM_1__drmMI, DISARM__drmA, DISARM__drmB, DISARM__drmC DISARM DISARM_2 4 4 DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, DISARM__drmC GAPS4 GAPS4 2 2 GAPS4__GAPS4a, GAPS4__GAPS4b Gabija Gabija 2 2 Gabija__GajA, Gabija__GajB_1 Gao_Ape Gao_Ape 1 1 Gao_Ape__ApeA Gao_Hhe Gao_Hhe 1 1 Gao_Hhe__HheA Gao_Iet Gao_Iet 2 2 Gao_Iet__IetA, Gao_Iet__IetS Gao_Mza Gao_Mza 5 5 Gao_Mza__MzaA, Gao_Mza__MzaB, Gao_Mza__MzaC, Gao_Mza__MzaD, Gao_Mza__MzaE Gao_Ppl Gao_Ppl 1 1 Gao_Ppl__PplA Gao_TerY Gao_TerY 3 3 Gao_TerY__TerYA, Gao_TerY__TerYB, Gao_TerY__TerYC Gao_Tmn Gao_Tmn 1 1 Gao_Tmn__TmnA Gao_Upx Gao_Upx 1 1 Gao_Upx__UpxA GasderMIN GasderMIN 1 1 GasderMIN__bGSDM Kiwa Kiwa 2 2 Kiwa__KwaA, Kiwa__KwaB Lamassu-Fam Lamassu-Amidase 2 2 Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Cap4_nuclease 2 2 Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-FMO 2 2 Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Fam 1 3 Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam Lamassu-Hydrolase 2 2 Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Hydrolase_Protease 3 3 Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Hypothetical 2 2 Lamassu-Fam__LmuA_effector_hypothetical, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2 Lamassu-Fam Lamassu-Lipase 2 2 Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Mrr 2 2 Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-PDDEXK 2 2 Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Protease 2 2 Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuA_effector_hypothetical Lamassu-Fam Lamassu-Sir2 2 2 Lamassu-Fam__LmuA_effector_Sir2, Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II Lamassu-Fam__LmuC_acc_Lipase Lamassu-Fam__LmuA_effector_Amidase, Lamassu-Fam__LmuA_effector_Cap4_nuclease, Lamassu-Fam__LmuA_effector_Cap4_nuclease_II, Lamassu-Fam__LmuA_effector_FMO, Lamassu-Fam__LmuA_effector_Hydrolase, Lamassu-Fam__LmuA_effector_Lipase, Lamassu-Fam__LmuA_effector_Mrr, Lamassu-Fam__LmuA_effector_PDDEXK, Lamassu-Fam__LmuA_effector_Protease, Lamassu-Fam__LmuA_effector_hypothetical Lit Lit 1 1 Lit__Lit Nhi Nhi 1 1 Nhi__Nhi NixI NixI 1 1 NixI__NixI NixI__Stix PD-T4-8 PD-T4-8 1 1 PD-T4-8__PD-T4-8 Pif Pif 2 2 Pif__PifA, Pif__PifC RADAR radar_I 2 2 radar_I__rdrA_I, radar_I__rdrB_I RADAR radar_II 3 3 radar_II__rdrA_II, radar_II__rdrB_II, radar_II__rdrD_II RexAB RexAB 2 2 RexAB__RexA, RexAB__RexB RloC RloC 1 1 RloC__RloC Rst_3HP Rst_3HP 3 3 Rst_3HP__Hp1, Rst_3HP__Hp2, Rst_3HP__Hp3 Rst_DUF4238 Rst_DUF4238 1 1 Rst_DUF4238__DUF4238_Pers Rst_HelicaseDUF2290 Rst_HelicaseDUF2290 2 2 Rst_HelicaseDUF2290__DUF2290, Rst_HelicaseDUF2290__Helicase Rst_Hydrolase-3Tm Rst_Hydrolase-Tm 2 2 Rst_Hydrolase-Tm__Hydrolase, Rst_Hydrolase-Tm__Hydrolase-Tm Rst_RT-nitrilase-Tm Rst_RT-Tm 2 2 Rst_RT-Tm__RT, Rst_RT-Tm__RT-Tm Rst_TIR-NLR Rst_TIR-NLR 1 1 Rst_TIR-NLR__TIR Shedu Shedu 1 1 Shedu__SduA Stk2 Stk2 1 1 Stk2__Stk2 Viperin Viperin 1 1 Viperin__pVip dCTPdeaminase dCTPdeaminase 1 1 dCTPdeaminase__dCTPdeaminase dGTPase dGTPase 1 1 dGTPase__Sp_dGTPase AbiA AbiA_large 1 1 AbiA_large__AbiA_large AbiA AbiA_small 2 2 AbiA_small__AbiA_SLATT, AbiA_small__AbiA_small AbiK AbiK 1 1 AbiK__AbiK AbiP2 AbiP2 1 1 AbiP2__AbiP2 Avs Avs_I 2 2 Avs_I__Avs1A, Avs_I__Avs1B, Avs_I__Avs1C Avs Avs_II 1 1 Avs_II__Avs2A Avs Avs_III 2 2 Avs_III__Avs3A, Avs_III__Avs3B Avs Avs_IV 1 1 Avs_IV__Avs4A Avs Avs_V 1 1 Avs_V__Avs5A DRT DRT6 1 1 DRT6__DRT6 DRT DRT7 1 1 DRT7__DRT7, DRT7__DRT7_small DRT DRT8 1 1 DRT8__DRT8 DRT8__DRT8b DRT DRT9 1 1 DRT9__DRT9 DRT DRT_1 2 2 DRT_1__drt1a, DRT_1__drt1b DRT DRT_2 1 1 DRT_2__drt2 DRT DRT_3 2 2 DRT_3__drt3a, DRT_3__drt3b DRT DRT_4 1 1 DRT_4__drt4 DRT DRT_5 1 1 DRT_5__drt5 DarTG DarTG 2 2 DarTG__DarG, DarTG__DarT Dsr Dsr_I 1 1 Dsr_I__Dsr1 Dsr Dsr_II 1 1 Dsr_II__Dsr2 FS_GIY_YIG FS_GIY_YIG 1 1 FS_GIY_YIG__GIY_YIG FS_HEPN_TM FS_HEPN_TM 2 2 FS_HEPN_TM__HEPN, FS_HEPN_TM__TM FS_HP FS_HP 1 1 FS_HP__HP FS_HP_SDH_sah FS_HP_SDH_sah 2 2 FS_HP_SDH_sah__HP, FS_HP_SDH_sah__SDH_sah FS_HsdR_like FS_HsdR_like 2 2 FS_HsdR_like__DUF6731, FS_HsdR_like__HP, FS_HsdR_like__HdrR FS_Sma FS_Sma 1 1 FS_Sma__Sma Gao_RL Gao_RL 4 4 Gao_RL__RL_A, Gao_RL__RL_B, Gao_RL__RL_C, Gao_RL__RL_D MqsRAC MqsRAC 2 2 MqsRAC__mqsC, MqsRAC__mqsR NLR NLR_like_bNACHT01 1 1 NLR_like_bNACHT01__NLR_like_bNACHT01 NLR NLR_like_bNACHT09 1 1 NLR_like_bNACHT09__NLR_like_bNACHT09 Old_exonuclease Old_exonuclease 1 1 Old_exonuclease__Old_exonuclease PD-Lambda-1 PD-Lambda-1 1 1 PD-Lambda-1__PD-Lambda-1 PD-Lambda-2 PD-Lambda-2 2 2 PD-Lambda-2__PD-Lambda-2_A, PD-Lambda-2__PD-Lambda-2_B PD-Lambda-2__PD-Lambda-2_C PD-Lambda-3 PD-Lambda-3 2 2 PD-Lambda-3__PD-Lambda-3_A, PD-Lambda-3__PD-Lambda-3_B PD-Lambda-4 PD-Lambda-4 2 2 PD-Lambda-4__PD-Lambda-4_A, PD-Lambda-4__PD-Lambda-4_B PD-Lambda-6 PD-Lambda-6 1 1 PD-Lambda-6__PD-Lambda-6 PsyrTA PsyrTA 2 2 PsyrTA__PsyrA, PsyrTA__PsyrT Rst_2TM_1TM_TIR Rst_2TM_1TM_TIR 3 3 Rst_2TM_1TM_TIR__Rst_1TM_TIR, Rst_2TM_1TM_TIR__Rst_2TM_TIR, Rst_2TM_1TM_TIR__Rst_TIR_tm Rst_gop_beta_cll Rst_gop_beta_cll 3 3 Rst_gop_beta_cll__beta, Rst_gop_beta_cll__cll, Rst_gop_beta_cll__gop Septu Septu 2 2 Septu__PtuA, Septu__PtuB Retron__RT_Tot ShosTA ShosTA 2 2 ShosTA__ShosA, ShosTA__ShosT Wadjet Wadjet 1 3 Wadjet__JetA_I Wadjet__JetB_I, Wadjet__JetC_I, Wadjet__JetD_I Wadjet Wadjet_I 3 3 Wadjet__JetA_I, Wadjet__JetB_I, Wadjet__JetC_I, Wadjet__JetD_I Wadjet Wadjet_II 3 3 Wadjet__JetA_II, Wadjet__JetB_II, Wadjet__JetC_II, Wadjet__JetD_II Wadjet Wadjet_III 3 3 Wadjet__JetA_III, Wadjet__JetB_III, Wadjet__JetC_III, Wadjet__JetD_III Azaca Azaca 2 3 Azaca__ZacA, Azaca__ZacB, Azaca__ZacC Butters_gp30_gp31 Butters_gp30_gp31 2 2 Butters_gp30_gp31__Butters_gp30, Butters_gp30_gp31__Butters_gp31 Butters_gp57r Butters_gp57r 1 1 Butters_gp57r__gp57r CapRel CapRel 1 1 CapRel__CapRel Charlie_gp32 Charlie_gp32 1 1 Charlie_gp32__gp32 DmdDE DdmDE 2 2 DdmDE__DdmE, DmdDE__DdmD Druantia Druantia_I 1 3 Druantia__DruE_1 Druantia_I__DruA, Druantia_I__DruB, Druantia_I__DruC, Druantia_I__DruD Druantia Druantia_II 1 3 Druantia__DruE_1 Druantia_II__DruF, Druantia_II__DruG, Druantia_II__DruM Druantia Druantia_III 2 2 Druantia_III__DruH, Druantia__DruE_1 Gao_Her Gao_Her_DUF 2 2 Gao_Her_DUF__DUF4297, Gao_Her_DUF__HerA_DUF Gao_Her Gao_Her_SIR 2 2 Gao_Her_SIR__HerA_SIR2, Gao_Her_SIR__SIR2 Gao_Qat Gao_Qat 4 4 Gao_Qat__QatA, Gao_Qat__QatB, Gao_Qat__QatC, Gao_Qat__QatD MMB_gp29_gp30 MMB_gp29_gp30 2 2 MMB_gp29_gp30__gp29, MMB_gp29_gp30__gp30 PD-T4-1 PD-T4-1 1 1 PD-T4-1__PD-T4-1 PD-T4-10 PD-T4-10 2 2 PD-T4-10__PD-T4-10_A, PD-T4-10__PD-T4-10_B PD-T4-2 PD-T4-2 2 2 PD-T4-2__PD-T4-2_A, PD-T4-2__PD-T4-2_B PD-T4-3 PD-T4-3 1 1 PD-T4-3__PD-T4-3 PD-T4-4 PD-T4-4 2 2 PD-T4-4__PD-T4-4_A, PD-T4-4__PD-T4-4_B PD-T4-5 PD-T4-5 1 1 PD-T4-5__PD-T4-5 PD-T4-7 PD-T4-7 1 1 PD-T4-7__PD-T4-7 PD-T4-9 PD-T4-9 2 2 PD-T4-9__PD-T4-9_A, PD-T4-9__PD-T4-9_C PD-T4-9__PD-T4-9_B PD-T7-2 PD-T7-2 2 2 PD-T7-2__PD-T7-2_A, PD-T7-2__PD-T7-2_B Panchino_gp28 Panchino_gp28 1 1 Panchino_gp28__gp28 Paris PARIS_I 2 2 Paris_I__AriA_AAA15, Paris_I__AriB_DUF4435_I Paris PARIS_II 2 2 Paris_II__AriA_AAA21, Paris_II__AriB_DUF4435_II Paris PARIS_II_merge 1 1 Paris_II_merge__AAA_21_DUF4435 Paris PARIS_I_merge 1 1 Paris_I_merge__AAA_15_DUF4435 Phrann_gp29_gp30 Phrann_gp29_gp30 2 2 Phrann_gp29_gp30__gp29, Phrann_gp29_gp30__gp30 SpbK SpbK 1 1 SpbK__SpbK Thoeris Thoeris_I 2 2 Thoeris_I__ThsA_new_grand, Thoeris__ThsB_Global Thoeris Thoeris_II 2 2 Thoeris_II__ThsA_new_petit, Thoeris__ThsB_Global Detocs Detocs 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC Detocs Detocs_REase 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC_REase Detocs Detocs_TOPRIM 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC_TOPRIM Detocs Detocs_hydrolase 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC_hydrolase Dnd Dnd_ABCDE 4 4 Dnd__DndB, Dnd__DndC, Dnd__DndD, Dnd__DndE Dnd__DndA Dnd Dnd_ABCDEFGH 7 7 Dnd_ABCDEFGH__DptF, Dnd_ABCDEFGH__DptG, Dnd_ABCDEFGH__DptH, Dnd__DndB, Dnd__DndC, Dnd__DndD, Dnd__DndE Dnd__DndA Dodola Dodola 2 2 Dodola__DolA, Dodola__DolB Dpd Dpd 4 4 Dpd__DpdA, Dpd__DpdB, Dpd__DpdC, Dpd__DpdD, Dpd__DpdE, Dpd__DpdF, Dpd__DpdG, Dpd__DpdH, Dpd__DpdI, Dpd__DpdJ, Dpd__DpdK Dpd__FolE, Dpd__QueC, Dpd__QueD, Dpd__QueE GAPS1 GAPS1 1 1 GAPS1__GAPS1 GAPS2 GAPS2 1 1 GAPS2__GAPS2 GAPS6 GAPS6 2 2 GAPS6__GAPS6a, GAPS6__GAPS6b Hachiman Hachiman 2 2 Hachiman__HamA_1, Hachiman__HamB Hna Hna 1 1 Hna__Hna ISG15-like ISG15-like 2 4 ISG15-like__BilA, ISG15-like__BilB, ISG15-like__BilC, ISG15-like__BilD JukAB JukAB 2 2 JukAB__JukA, JukAB__JukB Menshen Menshen 2 2 Menshen__NsnA, Menshen__NsnB, Menshen__NsnC_2507451963 Mok_Hok_Sok Mok_Hok_Sok 1 1 Mok_Hok_Sok__Hok, Mok_Hok_Sok__Mok Mokosh Mokosh_TypeII 1 1 Mokosh_TypeII__MkoC Mokosh Mokosh_Type_I 1 2 Mokosh_type_I__MkoB_A Mokosh_type_I__MkoA_A Mokosh Mokosh_Type_I_A 2 2 Mokosh_type_I__MkoA_A, Mokosh_type_I__MkoB_A Mokosh Mokosh_Type_I_B 2 2 Mokosh_type_I__MkoA_B, Mokosh_type_I__MkoB_B Mokosh Mokosh_Type_I_C 2 2 Mokosh_type_I__MkoA_C, Mokosh_type_I__MkoB_C Mokosh Mokosh_Type_I_D 2 2 Mokosh_type_I__MkoA_D, Mokosh_type_I__MkoB_D Mokosh Mokosh_Type_I_E 2 2 Mokosh_type_I__MkoA_E, Mokosh_type_I__MkoB_E PD-T4-6 PD-T4-6 1 1 PD-T4-6__PD-T4-6 PD-T7-1 PD-T7-1 1 1 PD-T7-1__PD-T7-1 PD-T7-3 PD-T7-3 1 1 PD-T7-3__PD-T7-3 PD-T7-4 PD-T7-4 1 1 PD-T7-4__PD-T7-4 PD-T7-5 PD-T7-5 1 1 PD-T7-5__PD-T7-5 RosmerTA RosmerTA 2 2 RosmerTA__RmrA_2585209417, RosmerTA__RmrT_2585209417 Shango Shango 1 2 Shango__SngA Shango__SngB, Shango__SngC SspBCDE SspBCDE 3 3 SspBCDE__SspB, SspBCDE__SspC, SspBCDE__SspD SspBCDE__SspE, SspBCDE__SspF, SspBCDE__SspG, SspBCDE__SspH Zorya Zorya_TypeI 3 3 Zorya_TypeI__ZorC, Zorya_TypeI__ZorD, Zorya__ZorA, Zorya__ZorB Zorya Zorya_TypeII 3 3 Zorya_TypeII__ZorE, Zorya__ZorA2, Zorya__ZorB Aditi Aditi 2 2 Aditi__DitA, Aditi__DitB BREX BREX 1 3 BREX__pglZB BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxC, BREX__brxD, BREX__brxE, BREX__brxF, BREX__brxHI, BREX__brxHII, BREX__brxL, BREX__brxP, BREX__pglW, BREX__pglX1, BREX__pglXI BREX BREX_I 2 3 BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxL, BREX__pglX1, BREX__pglZB BREX__brxC BREX__brxD, BREX__brxE, BREX__brxF, BREX__brxHI, BREX__brxHII, BREX__brxP, BREX__pglW, BREX__pglXI, BREX__pglY BREX BREX_II 3 3 BREX__brxD, BREX__brxHI, BREX__pglW, BREX__pglX1, BREX__pglY, BREX__pglZB BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxC, BREX__brxE, BREX__brxF, BREX__brxHII, BREX__brxL, BREX__brxP, BREX__pglXI BREX BREX_III 3 3 BREX__brxF, BREX__brxHII, BREX__pglXI, BREX__pglZB BREX__brxA_DUF1819, BREX__brxC, BREX__brxD, BREX__brxHI, BREX__pglX1, BREX__pglX2 BREX__brxB_DUF1788, BREX__brxE, BREX__brxL, BREX__brxP, BREX__pglW BREX BREX_IV 2 2 BREX__brxL, BREX__brxP BREX__brxC, BREX__pglZB BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxD, BREX__brxE, BREX__brxF, BREX__brxHI, BREX__brxHII, BREX__pglW, BREX__pglX1, BREX__pglX2, BREX__pglXI BREX BREX_V 2 4 BREX__brxHII, BREX__pglZB BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxC, BREX__pglX1 BREX__brxD, BREX__brxE, BREX__brxF, BREX__brxHI, BREX__brxL, BREX__brxP, BREX__pglW, BREX__pglXI BREX BREX_VI 2 4 BREX__brxE, BREX__pglZB BREX__brxA_DUF1819, BREX__brxB_DUF1788, BREX__brxC, BREX__brxD, BREX__brxHI, BREX__pglX1 BREX__brxF, BREX__brxHII, BREX__brxL, BREX__brxP, BREX__pglW, BREX__pglXI Borvo Borvo 1 1 Borvo__BovA Bunzi Bunzi 2 2 Bunzi__BnzA, Bunzi__BnzB CBASS CBASS 1 2 CBASS__Cyclase_SMODS CBASS__Effector_2TM_S_2TMBeta CBASS__E2, CBASS__HORMA, CBASS__TGT CBASS CBASS_I 2 2 CBASS__Cyclase_SMODS, CBASS__Effector_2TM_S_2TMBeta CBASS CBASS_II 3 3 CBASS__Cyclase_SMODS, CBASS__E2, CBASS__Effector_2TM_S_2TMBeta CBASS CBASS_III 3 3 CBASS__Cyclase_SMODS, CBASS__Effector_2TM_S_2TMBeta, CBASS__HORMA CBASS__TGT CBASS CBASS_IV 3 3 CBASS__Cyclase_SMODS, CBASS__Effector_2TM_S_2TMBeta, CBASS__TGT Dazbog Dazbog 2 2 Dazbog__DzbA, Dazbog__DzbB Eleos Eleos 2 2 Eleos__LeoA, Eleos__LeoB, Eleos__LeoBC, Eleos__LeoC MADS MADS 3 3 MADS__mad1, MADS__mad2, MADS__mad3, MADS__mad4, MADS__mad5, MADS__mad6, MADS__mad7, MADS__mad8 MazEF MazEF 2 2 MazEF__MazE, MazEF__MazF Olokun Olokun 2 2 Olokun__OloA, Olokun__OloB PfiAT PfiAT 2 2 PfiAT__PfiA, PfiAT__PfiT Pycsar Pycsar 1 2 Pycsar__AG_cyclase CBASS__Effector_2TM_S_2TMBeta CBASS__E2, CBASS__HORMA, CBASS__TGT Retron Retron_II 2 2 Retron_II__NDT, Retron__RT_Tot Retron Retron_III 2 2 Retron_III__PRTase, Retron_III__PRTase_WH, Retron__RT_Tot Retron_III__WH Retron Retron_IV 2 2 Retron_IV__2TM, Retron__RT_Tot Retron Retron_IX 1 2 Retron__RT_Tot Retron_IX__HEPN, Retron_IX__WHDNAB_E2F_TDP Retron Retron_I_A 1 3 Retron__RT_Tot Retron_I_A__ATPase_TypeIA, Retron_I_A__HNH_TIGR02646 Retron Retron_I_B 1 2 Retron__RT_Tot Retron_I_B__ATPase_TOPRIM_COG3593 Retron Retron_I_C 1 1 Retron_I_C__RT_1_C1 Retron Retron_V 2 2 Retron_V__CSD, Retron__RT_Tot Retron Retron_VI 2 2 Retron_VI__HTH, Retron__RT_Tot Retron Retron_VIII 2 2 Retron_VIII__DUF626, Retron__RT_Tot Retron Retron_VII_1 1 1 Retron_VII_1__RT_7_A1 Retron Retron_VII_2 2 2 Retron_VII_2__DUF3800, Retron__RT_Tot Retron Retron_X 2 2 Retron_X__VHL, Retron__RT_Tot Retron Retron_XI 1 1 Retron_XI__RT_11 Retron Retron_XII 1 1 Retron_XII__RT_12 Retron Retron_XIII 1 2 Retron__RT_Tot Retron_XIII__ARM, Retron_XIII__WHSWIM RnlAB RnlAB 2 2 RnlAB__RnlA, RnlAB__RnlB SEFIR SEFIR 1 1 SEFIR__bSEFIR SanaTA SanaTA 2 2 SanaTA__SanaA, SanaTA__SanaT SoFIC SoFic 1 1 SoFic__SoFic Tiamat Tiamat 1 1 Tiamat__TmtA Uzume Uzume 1 1 Uzume__UzuA pAgo pAgo 1 3 pAgo__pAgo_LongA, pAgo__pAgo_LongB, pAgo__pAgo_S1A, pAgo__pAgo_S2B, pAgo__pAgo_SPARTA pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__SIR2APAZ, pAgo__TIRAPAZ, pAgo__XAPAZ pAgo pAgo_LongA 1 1 pAgo__pAgo_LongA pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__SIR2APAZ, pAgo__TIRAPAZ, pAgo__XAPAZ, pAgo__pAgo_LongB, pAgo__pAgo_S1A, pAgo__pAgo_S1B, pAgo__pAgo_S2B, pAgo__pAgo_SPARTA pAgo pAgo_LongB 1 1 pAgo__pAgo_LongB pAgo__EabAgaM pAgo__SIR2APAZ, pAgo__TIRAPAZ, pAgo__XAPAZ, pAgo__pAgo_LongA, pAgo__pAgo_S1A, pAgo__pAgo_S1B, pAgo__pAgo_S2B, pAgo__pAgo_SPARTA pAgo pAgo_S1A 1 1 pAgo__pAgo_S1A pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__SIR2APAZ, pAgo__TIRAPAZ, pAgo__XAPAZ, pAgo__pAgo_LongA, pAgo__pAgo_LongB, pAgo__pAgo_S1B, pAgo__pAgo_S2B, pAgo__pAgo_SPARTA pAgo pAgo_S1B 1 1 pAgo__pAgo_S1B pAgo__SIR2APAZ pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__TIRAPAZ, pAgo__XAPAZ, pAgo__pAgo_LongA, pAgo__pAgo_LongB, pAgo__pAgo_S1A, pAgo__pAgo_S2B, pAgo__pAgo_SPARTA pAgo pAgo_S2B 1 1 pAgo__pAgo_S2B pAgo__XAPAZ pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__SIR2APAZ, pAgo__TIRAPAZ, pAgo__pAgo_LongA, pAgo__pAgo_LongB, pAgo__pAgo_S1A, pAgo__pAgo_S1B, pAgo__pAgo_SPARTA pAgo pAgo_SPARTA 1 1 pAgo__pAgo_SPARTA pAgo__TIRAPAZ pAgo__EabAgaM, pAgo__EcAgaN, pAgo__GbbAgaS, pAgo__SIR2APAZ, pAgo__XAPAZ, pAgo__pAgo_LongA, pAgo__pAgo_LongB, pAgo__pAgo_S1A, pAgo__pAgo_S1B, pAgo__pAgo_S2B PD-Lambda-5 PD-Lambda-5 2 2 PD-Lambda-5__PD-Lambda-5_A, PD-Lambda-5__PD-Lambda-5_B PrrC PrrC 2 2 PrrC__EcoprrI, PrrC__PrrC RM__Type_I_REases, RM__Type_I_S RM RM_Type_I 2 2 RM__Type_I_MTases, RM__Type_I_REases RM__Type_I_S RM RM_Type_II 2 2 RM_Type_II__Type_II_MTases, RM_Type_II__Type_II_REases RM RM_Type_IIG 1 1 RM_Type_IIG__Type_IIG BREX__pglZB, DISARM__drmB RM RM_Type_III 2 2 RM_Type_III__Type_III_MTases, RM_Type_III__Type_III_REases RM RM_Type_IV 1 1 RM_Type_IV__Type_IV_REases Cas CAS_Class1-Subtype-I-A 1 2 cas5a_I-A_1, cas7_I-A_1, cas8a1_I-A_1, csa5gr11_I-A_3 cas1_I_II_III_IV_V_VI_8, cas2_I_II_III_IV_V_VI_5, cas3HD_I_1, cas3_I_5, cas4_I-A_1, cas4_I_II_III_IV_V_VI_1, cas5_I-A_1, cas6_I_II_III_IV_V_VI_22, cas7_I_15 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_4, PEPT_D_III-A_1, WYL_I_II_III_IV_V_VI_1, casR_I_1, csm6_III_3, csm6_III_6 Cas CAS_Class1-Subtype-I-B 1 2 cas5_I-B_6, cas7_I-B_6, cas8b2_I-B_2 cas11b_I-B_2, cas1_I_II_III_IV_V_VI_7, cas2_I_II_III_IV_V_VI_3, cas3_I_5, cas4_I_II_III_IV_V_VI_6, cas5_I_9, cas6_I-B_III_1, cas7_I_15 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, TniQ_I-F_1, WYL_I_II_III_IV_V_VI_1, casR_I_1, csm6_III_3, csx20_I_III_1 Cas CAS_Class1-Subtype-I-C 1 2 cas5_I-C_11, cas7_I-C_13, cas8c_I-C_4 cas1_I_II_III_IV_V_VI_6, cas2_I_II_III_IV_V_VI_3, cas3HD_I_1, cas3_I_5, cas4_I_II_III_IV_V_VI_1, cas6_I_II_III_IV_V_VI_20, cas7b_I-B_I-C_2 DEDDh_I_II_III_IV_V_VI_1, HEAT_CxxC_PDDEXK_I-C_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, casR_I_1 Cas CAS_Class1-Subtype-I-D 1 2 cas10d_I-D_3, cas4_I-D_1, cas6_I-D_2, csc1gr5_I-D_2, csc2gr7_I-D_1 HTH_I-D_2, cas11d_I-D_1, cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_3, cas3HD_I_1, cas3_I-D_4, cas3_I_2, cas4_I_II_III_IV_V_VI_1, cas6_I-A_III-D_3 HEAT_CxxC_PDDEXK_I-C_1, PD_DExK_I_II_III_IV_V_VI_5, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, casR_I_1, csx15_I_III_1 Cas CAS_Class1-Subtype-I-E 1 2 cas1_I-E_1, cas5_I-E_3, cas6e_I_II_III_IV_V_VI_1, cas7_I-E_16, cas8e_I-E_1, cse2gr11_I-E_2 cas2_I-E_1, cas3HD_I-E_4, cas3_I_5, cas4_I_II_III_IV_V_VI_6, cas5_I_9 DEDDh_I_II_III_IV_V_VI_1, PrimPol_I_II_III_IV_V_VI_1, RT_I-E_1, WYL_I_II_III_IV_V_VI_1, casR_I_1 Cas CAS_Class1-Subtype-I-F 1 2 cas1_I-F_1, cas3f_I-F_1, cas5f_I-F_4, cas7f_I-F_3, cas8f_I-F_8 cas3_I_5, cas5_I_9, cas6f_I_II_III_IV_V_VI_3 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_4, RT_I_II_III_IV_V_VI_1, TniQ_I-F_1, WYL_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, casR_I_1 Cas CAS_Class1-Subtype-I-G 1 2 cas3_I-G_3, cas5u_I-G_1, cas7_I-G_4, cas8u1_I-G_1, csb3_I-G_1 cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_3, cas3_I_2, cas4_I_II_III_IV_V_VI_1, cas6e_I_II_III_IV_V_VI_3 DEDDh_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1 Cas CAS_Class1-Subtype-III-A 1 2 cas10_III-A_1, csm2gr11_III-A_15, csm3gr7_III-A_1, csm4gr5_III-A_2, csm4gr5_III-A_3, csm5gr7_III-A_1, csm5gr7_III-A_2, csx26_III_1 TPR_III-A_2, TPR_III-A_4, cas10_III_7, cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_5, cas4_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_15, csm3gr7_III-A_III-D_10, csm3gr7_III_IV, csm6_III_2, csx1_III_10, csx22_III-A_1, csx23_III-D_III-A_1 SSgr11_III-F_1 HTH_III_1, PD_DExK_I_II_III_IV_V_VI_4, PEPT_D_III-A_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, casR_III_1, csx15_I_III_1, csx16_III-A_1, csx20_I_III_1, csx3_I_III_1 Cas CAS_Class1-Subtype-III-B 1 2 cas10_III-B_12, cmr1gr7_III-B_1, cmr5gr11_III-B_18, cmr6gr7_III-B_1, cmr7_III-B_1 PrimPol_I_II_III_IV_V_VI_1, cas10_III_1, cas10_III_7, cas1_III_1, cas2_I_II_III_IV_V_VI_3, cas4_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_17, casR_III-B_9, cmr1gr7_III-B_III-C_3, cmr3gr5_III-B_III-C_5, cmr4gr7_III-B_III-C_2, corA_III-B_2, csm3gr7_III_IV, csm6_III_3, csm6_III_7, csx18_III_1, csx1_III_10 cas10_III-C_3 DEDDh_I_II_III_IV_V_VI_1, HTH_III_1, PD_DExK_I_II_III_IV_V_VI_5, RT_I_II_III_IV_V_VI_1, TPR_III-A_2, WYL_I_II_III_IV_V_VI_1, corA_III-B_III-D_1, csx15_I_III_1, csx16_III_1, csx16_III_2, csx20_I_III_1, csx3_I_III_1 Cas CAS_Class1-Subtype-III-C 1 2 cas10_III-C_3, cmr1gr7_III-C_1, cmr3gr5_III-C_1, cmr5gr11_III-C_11, cmr6gr7_III-C_1 Toprim_III-C_1, cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_3, cas4_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_17, cmr1gr7_III-B_III-C_3, cmr3gr5_III-B_III-C_2, cmr4gr7_III-B_III-C_2, csm3gr7_III_IV RT_I_II_III_IV_V_VI_1, csm6_III_7, csx3_I_III_1 Cas CAS_Class1-Subtype-III-D 1 2 cas10_III-D_1, cas6_III-D_4, csm2gr11_III-D_5, csm3gr7_III-D_1, csm4gr5_III-D_2, csx10gr5_III-D_3, csx19_III-D_2, csx24_III-D_1, csx25_III-D_1 cas10_III_1, cas10_III_6, cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_5, cas4_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_17, casR_III-D_10, csm2gr11_III-A_13, csm3gr7_III-A_III-D_10, csm3gr7_III_IV, csm6_III_2, csx1_III_10, csx21_III-D_1, csx23_III-D_III-A_1 DEDDh_I_II_III_IV_V_VI_1, DHH_CorA_III-B_III-D_1, HTH_III_1, PD_DExK_I_II_III_IV_V_VI_4, PEPT_D_III-A_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, casR_III_1, casR_I_2, cmr3gr5_III-B_III-C_5, corA_III-B_III-D_1, csx15_I_III_1, csx16_III_2, csx18_III_1, csx20_I_III_1, csx3_I_III_1 Cas CAS_Class1-Subtype-III-E 1 2 gRAMP_III-E_1 RT_I_II_III_IV_V_VI_1, cas10_III_6, cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_3 Cas CAS_Class1-Subtype-III-F 1 2 SSgr11_III-F_1, cas10_III-F_1, cas5_III-F_1 RT_I_II_III_IV_V_VI_1, cas10_III_6, cas6_I_II_III_IV_V_VI_12, csm3gr7_III-A_III-D_2, csm3gr7_III_IV, csm6_III_7 cas1_I_II_III_IV_V_VI_10, cas2_I_II_III_IV_V_VI_3 Cas CAS_Class1-Subtype-IV-A 1 2 csf1gr8_IV-A_3, csf2gr7_IV-A_1, csf3gr5_IV-A_1, csf5gr6_IV-A_1 PD_DExK_I_II_III_IV_V_VI_1, cas1_I-E_1, cas1_I-F_1, cas6e_I_II_III_IV_V_VI_3, csf1gr8_IV_1, csf2gr7_IV_1, csf4_IV-A_1, csm3gr7_III_IV LSIVC_IV-C_1, SSIVC_IV-C_1, csf4gr11_IV-B_2 DEDDh_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1 Cas CAS_Class1-Subtype-IV-B 1 2 csf2gr7_IV-B_1, csf3gr5_IV-B_1, csf4gr11_IV-B_2 csf1gr8_IV-B_1, csf2gr7_IV_1, csf5gr6_IV-A_1 DEDDh_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cysH_IV-B_1 Cas CAS_Class1-Subtype-IV-C 1 2 LSIVC_IV-C_1, SSIVC_IV-C_1, cas10-like_IV-C_1, cas11_IV-C_1, csf3gr5_IV-C_4 cas2_I_II_III_IV_V_VI_3, cas4_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_10, csf2gr7_IV_1 DEDDh_I_II_III_IV_V_VI_1 Cas CAS_Class1-Subtype-IV-D 1 2 csf2gr7_IV-B_1, csf3gr5_IV-B_1, recD_IV-D_1 cas6_IV-D_1, csf1gr8_IV-A_3, csf2gr7_IV_1, csf4gr11_IV-B_2, csf5gr6_IV-A_1 DEDDh_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cas1_I-E_1 Cas CAS_Class1-Subtype-IV-E 1 2 cas6_IV-E_1, csf3-csf1_IV-E_1 PD_DExK_I_II_III_IV_V_VI_1, cas6_I_II_III_IV_V_VI_15, csf2gr7_IV_1, csf4_IV-E_1, csm3gr7_III_IV DEDDh_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, cas1_I-F_1 Cas CAS_Class1-Type-I 1 2 cas10d_I-D_3, cas5_I-A_1, cas7_I-A_1, cas8a1_I-A_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas6_I_II_III_IV_V_VI_7, csa5gr11_I-A_3, csb3_I-G_1 DEDDh_I_II_III_IV_V_VI_1, HEAT_CxxC_PDDEXK_I-C_1, HTH_I-D_2, PD_DExK_I_II_III_IV_V_VI_1, PEPT_D_III-A_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, cas3_I_5, cas4_I_II_III_IV_V_VI_1, casR_I_1, csx1_III_20, csx1_III_21, csx1_III_7, csx20_I_III_1, csx20_I_III_3, csx3_I_III_1 Cas CAS_Class1-Type-III 1 2 cas10_III_1, cmr7_III-B_1, csm3gr7_III-A_1, csm4gr5_III-A_3, gRAMP_III-E_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_5, cas6_I_II_III_IV_V_VI_17, csm2gr11_III-A_15, csm3gr7_III_IV, csx18_III_1, csx19_III-D_2 DEDDh_I_II_III_IV_V_VI_1, DHH_CorA_III-B_III-D_1, HTH_III_1, PD_DExK_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_4, PD_DExK_I_II_III_IV_V_VI_5, PEPT_D_III-A_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, TPR_III-A_2, TPR_III-A_4, Toprim_III-C_1, WYL_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_2, WYL_I_II_III_IV_V_VI_3, WYL_I_II_III_IV_V_VI_4, cas4_I_II_III_IV_V_VI_4, casR_III-B_9, cmr3gr5_III-B_III-C_5, corA_III-B_2, corA_III-B_III-D_1, corA_III-D_3, corA_III-D_5, csm6_III_2, csx15_I_III_1, csx16_III-A_1, csx16_III_1, csx16_III_2, csx1_III_10, csx20_I_III_1, csx20_I_III_2, csx20_I_III_3, csx21_III-D_1, csx22_III-A_1, csx23_III-D_III-A_1, csx24_III-D_1, csx25_III-D_1, csx26_III_1, csx3_I_III_1, csx3_I_III_2, csx3_I_III_3, csx3_I_III_4 Cas CAS_Class1-Type-IV 1 2 LSIVC_IV-C_1, SSIVC_IV-C_1, cas10-like_IV-C_1, cas11_IV-C_1, csf1gr8_IV-A_3, csf2gr7_IV-A_1, csf3-csf1_IV-E_1, csf3gr5_IV-A_1, csf4gr11_IV-B_2, csf5gr6_IV-A_1 cas2_I_II_III_IV_V_VI_3, cas4_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1, cas6_I_II_III_IV_V_VI_15, csf4_IV-A_1, recD_IV-D_1 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_4, PD_DExK_I_II_III_IV_V_VI_5, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cas1_I-E_1, cas1_I-F_1, csf1gr8_IV_1, csm3gr7_III_IV Cas CAS_Class2-Subtype-II-A 1 2 cas9_II-A_1, csn2_II-A_4 cas1_I_II_III_IV_V_VI_5, cas2_I_II_III_IV_V_VI_6, cas9_II-A_II-B_II-C_3 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4 Cas CAS_Class2-Subtype-II-B 1 2 cas9_II-B_2 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_13, cas4_I_II_III_IV_V_VI_1 PD_DExK_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-II-C 1 2 cas9_II-A_II-B_II-C_1 cas1_I_II_III_IV_V_VI_5, cas2_I_II_III_IV_V_VI_6, cas6_I_II_III_IV_V_VI_20 csn2_II-A_4 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4 Cas CAS_Class2-Subtype-V-A 1 2 cas12a_V-A_3, cas4_V_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 PD_DExK_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4 Cas CAS_Class2-Subtype-V-B 1 2 cas12b1_V-B_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-V-C 1 1 cas12c_V-C_1 cas1_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-V-D 1 1 cas12d_V-D_1 cas1_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-V-E 1 2 cas12e_V-E_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-V-F 1 2 cas12f1_V-F_3 cas12f4_V-F_1, cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 cas12f2_V-F_2, cas12f2_V-F_2 Cas CAS_Class2-Subtype-V-G 1 1 cas12g_V-G_1 Cas CAS_Class2-Subtype-V-H 1 1 cas12h_V-H_1 Cas CAS_Class2-Subtype-V-I 1 1 cas12i_V-I_1 Cas CAS_Class2-Subtype-V-K 1 1 cas12k_V-K_1 cas4_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-VI-A 1 1 cas13a_VI-A_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1 RT_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-VI-B 1 1 cas13b_VI-B_1 csx27_VI-B_1, csx28_VI-B_1, tm_4_VI-B_1 DEDDh_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-VI-C 1 1 cas13c_VI-C_1 Cas CAS_Class2-Subtype-VI-D 1 1 cas13d_VI-D_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1 WYL_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-VI-X 1 1 cas13x_VI-X_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1 WYL_I_II_III_IV_V_VI_1 Cas CAS_Class2-Subtype-VI-Y 1 1 cas13y_VI-Y_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1 WYL_I_II_III_IV_V_VI_1 Cas CAS_Class2-Type-II 1 2 cas9_II-A_1, csn2_II-A_3 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 DEDDh_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_1, PD_DExK_I_II_III_IV_V_VI_4, PD_DExK_I_II_III_IV_V_VI_5, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cas6_I_II_III_IV_V_VI_20 Cas CAS_Class2-Type-V 1 2 cas12a_V-A_3, cas4_V_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas4_I_II_III_IV_V_VI_1 PD_DExK_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_4, cas12f2_V-F_2 Cas CAS_Class2-Type-VI 1 1 cas13a_VI-A_1, cas13c_VI-C_1 cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, csx28_VI-B_1, tm_4_VI-B_1 DEDDh_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, WYL_I_II_III_IV_V_VI_1 Cas CAS_Cluster 1 2 LSIVC_IV-C_1, SSIVC_IV-C_1, SSgr11_III-F_1, cas10_III-A_1, cas10_III-A_2, cas10_III-B_12, cas10_III-B_8, cas10_III-C_3, cas10_III-D_1, cas10_III-D_2, cas10_III-D_3, cas10_III-F_1, cas10_III_1, cas10_III_6, cas10_III_7, cas10d_I-D_3, cas11_III-D_1, cas11d_I-D_1, cas12a_V-A_3, cas12b1_V-B_1, cas12c_V-C_1, cas12d_V-D_1, cas12e_V-E_1, cas12g_V-G_1, cas12h_V-H_1, cas12i_V-I_1, cas12k_V-K_1, cas13a_VI-A_1, cas1_I_II_III_IV_V_VI_1, cas2_I_II_III_IV_V_VI_1, cas5_I-A_1, cas5_I-B_1, cas5_I-C_5, cas5_I-E_3, cas5a_I-A_1, cas5f_I-F_4, cas6e_I_II_III_IV_V_VI_1, cas7_I-A_1, cas7_I-A_2, cas7_I-B_1, cas7_I-B_6, cas7_I-C_7, cas7_I-E_2, cas7_I-G_4, cas7_I_15, cas7f_I-F_3, cas8a1_I-A_1, cas8b2_I-B_2, cas8c_I-C_4, cas8e_I-E_1, cas8f_I-F_8, cas8u1_I-G_1, cas9_II-A_II-B_II-C_1, cmr1gr7_III-B_1, cmr3gr5_III-B_III-C_5, cmr4gr7_III-B_III-C_2, cmr5gr11_III-B_18, cmr5gr11_III-C_11, cmr6gr7_III-B_1, cmr7_III-B_1, csa5gr11_I-A_3, csc1gr5_I-D_2, csc2gr7_I-D_1, cse2gr11_I-E_2, csf1gr8_IV-A_3, csf2gr7_IV-A_1, csf3gr5_IV-A_1, csf4gr11_IV-B_2, csf5gr6_IV-A_1, csm2gr11_III-A_15, csm2gr11_III-D_5, csm3gr7_III-A_1, csm4gr5_III-A_3, csm5gr7_III-A_1, csn2_II-A_3, csx10gr5_III-D_3, gRAMP_III-E_1 cas11b_I-B_2, csx28_VI-B_1, tm_4_VI-B_1 DEDDh_I_II_III_IV_V_VI_1, HEAT_CxxC_PDDEXK_I-C_1, HTH_I-D_2, PEPT_D_III-A_1, PrimPol_I_II_III_IV_V_VI_1, RT_I_II_III_IV_V_VI_1, Toprim_III-C_1, cas3_I_5, cas4_I_II_III_IV_V_VI_1, cas5u_I-G_1, cas6_I_II_III_IV_V_VI_7, cas6f_I_II_III_IV_V_VI_1, casR_I_1, corA_III-B_2, csb3_I-G_1, csf1gr8_IV_1, csm6_III_2, csx16_III-A_1, csx19_III-D_2, csx1_III_10