diseaseId,targetId_genename,targetId,targetFromSourceId,Max Completed Clinical Phase,Associated drugId(s),drugbank,Target/Enzyme/Transporter,Pharmacological action,Therapeutic Intent,Notes
MONDO_0004976,MPO,ENSG00000005381,P05164,2,CHEMBL4297594,DB12440,Target,Inhibitor,Disease-modifying,
MONDO_0004976,SCN4A,ENSG00000007314,P35499,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,(DB00740 and CHEMBL3707183 for DMT)
MONDO_0004976,KCNQ1,ENSG00000053918,P51787,2,CHEMBL41355,DB04953,,,Disease-modifying,
MONDO_0004976,PDE4A,ENSG00000065989,P27815,2,CHEMBL19449,DB05266,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,ROCK1,ENSG00000067900,Q13464,2,CHEMBL38380,DB08162,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,FGFR3,ENSG00000068078,P22607,3,CHEMBL1908391,DB11526,,Inhibitor,Disease-modifying,
MONDO_0004976,MAOB,ENSG00000069535,P27338,2,CHEMBL887,DB01367,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,DRD4,ENSG00000069696,P21917,2,CHEMBL715,DB00334,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,PTGS2,ENSG00000073756,P35354,2,CHEMBL118,DB00482,Enzyme,Inhibitor,Disease-modifying,
MONDO_0004976,KCNQ2,ENSG00000075043,O43526,2,CHEMBL41355,DB04953,Target,Unknown,Disease-modifying,
MONDO_0004976,GSK3B,ENSG00000082701,P49841,3,CHEMBL1200826,DB14509,Target,Unknown,Disease-modifying,
MONDO_0008458,GSK3A,ENSG00000105723,P49840,2,CHEMBL1200826,DB14509,Target,Inhibitor,Disease-modifying,
MONDO_0004976,PDE10A,ENSG00000112541,Q9Y233,2,CHEMBL19449,DB05266,,,Disease-modifying,
MONDO_0004976,PDE4D,ENSG00000113448,Q08499,2,CHEMBL19449,DB05266,Target,Inhibitor,Disease-modifying,
MONDO_0004976,PDGFRB,ENSG00000113721,P09619,3,CHEMBL1908391,DB11526,,Inhibitor,Disease-modifying,
MONDO_0004976,KCNQ4,ENSG00000117013,P56696,2,CHEMBL41355,DB04953,Target,Unknown,Disease-modifying,
MONDO_0004976,PDE4C,ENSG00000105650,Q08493,2,CHEMBL19449,DB05266,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,HTR2A,ENSG00000102468,P28223,2,CHEMBL715,DB00334,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,FKBP1A,ENSG00000088832,P62942,2,"CHEMBL269732, CHEMBL413","DB00864, DB00877",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,PDGFRA,ENSG00000134853,P16234,3,CHEMBL1908391,DB11526,,Inhibitor,Disease-modifying,
MONDO_0004976,ESR1,ENSG00000091831,P03372,2,"CHEMBL83, CHEMBL786        ",DB00675,Target,"Agonist, Antagonist: Drug interacts directly with the target as part of its mechanism of action",Disease-modifying,
MONDO_0004976,IL2RB,ENSG00000100385,P14784,2,CHEMBL1201438,,,Agonist,Disease-modifying,
MONDO_0004976,RBX1,ENSG00000100387,P62877,2,CHEMBL468,DB01041,,,Disease-modifying,
MONDO_0004976,TUBB1,ENSG00000101162,Q9H4B7,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,TNNC2,ENSG00000101470,P02585,3,"CHEMBL3039529, CHEMBL4297600","DB12209, DB15256",Target,Modulator,Both,(DB12209 is DMT)
MONDO_0004976,CD40LG,ENSG00000102245,P29965,2,CHEMBL4594460,,,Inhibitor,Disease-modifying,
MONDO_0004976,TUBB4A,ENSG00000104833,P04350,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,GRIN2D,ENSG00000105464,O15399,2,CHEMBL807,DB01043,,,Disease-modifying,
MONDO_0004976,IMPDH1,ENSG00000106348,P20839,2,CHEMBL1456,DB00688,Target,"Inhibitor, Inducer: Drug interacts directly with the target as part of its mechanism of action",Disease-modifying,
MONDO_0004976,CRBN,ENSG00000113851,Q96SW2,2,CHEMBL468,DB01041,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,GRIN3B,ENSG00000116032,O60391,2,CHEMBL807,DB01043,,,Disease-modifying,
MONDO_0004976,ROCK2,ENSG00000134318,O75116,2,CHEMBL38380,DB08162,Target,Unknown,Disease-modifying,
MONDO_0004976,TUBB2A,ENSG00000137267,Q13885,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,TUBB2B,ENSG00000137285,Q9BVA1,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,PDE5A,ENSG00000138735,O76074,2,CHEMBL19449,DB05266,,,Disease-modifying,
MONDO_0004976,CUL4A,ENSG00000139842,Q13619,2,CHEMBL468,DB01041,,,Disease-modifying,
MONDO_0004976,C5,ENSG00000106804,P01031,2,"CHEMBL4298207, CHEMBL3989986        ",,,Inhibitor,Disease-modifying,
MONDO_0004976,HTR2C,ENSG00000147246,P28335,2,CHEMBL715,DB00334,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,ALDH5A1,ENSG00000112294,P51649,3,"CHEMBL109, CHEMBL433	",DB00313,Target,Inhibitor,Disease-modifying,(DB00313 failed to show significant results)
MONDO_0004976,KCNQ5,ENSG00000185760,Q9NR82,2,CHEMBL41355,DB04953,Target,Unknown,Disease-modifying,
MONDO_0004976,TUBB4B,ENSG00000188229,P68371,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,GHR,ENSG00000112964,P10912,2,CHEMBL1201621,,,Agonist,Disease-modifying,
MONDO_0004976,KCNQ3,ENSG00000184156,O43525,2,CHEMBL41355,DB04953,Target,Modulator: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,NR3C1,ENSG00000113580,P04150,2,"CHEMBL635, CHEMBL650","DB00635, DB00959",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,TUBB3,ENSG00000258947,Q13509,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,TUBB8,ENSG00000261456,Q3ZCM7,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,GRIN2C,ENSG00000161509,Q14957,2,CHEMBL807,DB01043,,,Disease-modifying,
MONDO_0004976,DDB1,ENSG00000167986,Q16531,2,CHEMBL468,DB01041,,,Disease-modifying,
MONDO_0004976,TNNC1,ENSG00000114854,P63316,3,CHEMBL2051955,DB00922,Target,Potentiator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,RTN4,ENSG00000115310,Q9NQC3,2,CHEMBL2108679,,Target,,Disease-modifying,
MONDO_0004976,IL1R1,ENSG00000115594,P14778,2,CHEMBL1201570,,,Antagonist,Disease-modifying,
MONDO_0004976,TNNT2,ENSG00000118194,P45379,3,CHEMBL2051955,DB00922,,,Symptomatic,
MONDO_0004976,TNNI3,ENSG00000129991,P19429,3,CHEMBL2051955,DB00922,,,Symptomatic,
MONDO_0004976,TNNT3,ENSG00000130595,P45378,3,"CHEMBL4297600, CHEMBL3039529","DB15256, DB12209",,,Both,(DB12209 is DMT)
MONDO_0004976,CNR1,ENSG00000118432,P21554,2,"CHEMBL190461, CHEMBL465","DB09061, DB00470",Target,"Antagonist, Modulator: Drug interacts directly with the target as part of its mechanism of action",Symptomatic,
MONDO_0004976,CSF3R,ENSG00000119535,Q99062,2,CHEMBL1201567,,,,Disease-modifying,
MONDO_0004976,GRIA3,ENSG00000125675,P42263,2,CHEMBL1214124,DB08883,Target,Inhibitor,Disease-modifying,
MONDO_0004976,GRIA2,ENSG00000120251,P42262,2,"CHEMBL1214124, CHEMBL61872","DB08883, DB04982",Target,Inhibitor,Disease-modifying,
MONDO_0004976,S1PR4,ENSG00000125910,O95977,2,"CHEMBL314854, CHEMBL544665        ",DB08868,Target,Modulator,Disease-modifying,
MONDO_0004976,SRD5A3,ENSG00000128039,Q9H8P0,2,CHEMBL1200969,DB01126,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,TNNI2,ENSG00000130598,P48788,3,"CHEMBL3039529, CHEMBL4297600","DB12209, DB15256",,,Both,(DB12209 is DMT)
MONDO_0004976,IMPA1,ENSG00000133731,P29218,3,CHEMBL1200826,DB14509,Target,Unknown,Disease-modifying,
MONDO_0004976,IL2RA,ENSG00000134460,P01589,2,"CHEMBL1201438, CHEMBL1201439        ",,,Agonist,Disease-modifying,
MONDO_0004976,SCN2A,ENSG00000136531,Q99250,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,(DB00740 and CHEMBL3707183 for DMT)
MONDO_0004976,IGF1R,ENSG00000140443,P08069,3,CHEMBL1201716,,,Agonist,Disease-modifying,
MONDO_0004976,SOD1,ENSG00000142168,ENSG00000142168,4,CHEMBL3833346,,,Antisense inhibitor,Disease-modifying,
MONDO_0004976,SCN1A,ENSG00000144285,P35498,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,(DB00740 and CHEMBL3707183 for DMT)
MONDO_0004976,SRD5A1,ENSG00000145545,P18405,2,CHEMBL1200969,DB01126,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,SIGMAR1,ENSG00000147955,Q99720,3,CHEMBL52440,DB00514,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,DRD2,ENSG00000149295,P14416,2,"CHEMBL715, CHEMBL596802","DB00334, DB11947",Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Both,(DB11947 for DMT)
MONDO_0004976,DRD3,ENSG00000151577,P35462,2,CHEMBL715,DB00334,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0004976,PDE3B,ENSG00000152270,Q13370,3,CHEMBL2051955,DB00922,,,Symptomatic,
MONDO_0004976,GRIA4,ENSG00000152578,P48058,2,CHEMBL1214124,DB08883,Target,Inhibitor,Disease-modifying,
MONDO_0004976,SCN3A,ENSG00000153253,Q9NY46,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,
MONDO_0004976,GRIA1,ENSG00000155511,P42261,2,"CHEMBL1214124, CHEMBL61872","DB08883, DB04982",Target,"Antagonist, Modulator: Drug interacts directly with the target as part of its mechanism of action",Disease-modifying,
MONDO_0004976,KIT,ENSG00000157404,P10721,3,CHEMBL1908391,DB11526,,Inhibitor,Disease-modifying,
MONDO_0004976,IL6R,ENSG00000160712,P08887,2,CHEMBL1237022,,,Inhibitor,Disease-modifying,
MONDO_0004976,SCN11A,ENSG00000168356,Q9UI33,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",Target,Blocker,Both,
MONDO_0004976,ADRB2,ENSG00000169252,P07550,2,CHEMBL49080,DB01407,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,SCN9A,ENSG00000169432,Q15858,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,
MONDO_0004976,S1PR1,ENSG00000170989,P21453,2,"CHEMBL314854, CHEMBL544665	",DB08868,Target,Modulator: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,PDE3A,ENSG00000172572,Q14432,3,"CHEMBL2051955, CHEMBL19449","DB00922, DB05266",Target,Inhbitor,Both,(DB05266 is DMT)
MONDO_0004976,TUBB6,ENSG00000176014,Q9BUF5,2,CHEMBL107,DB01394,,,Disease-modifying,
MONDO_0004976,GRIN1,ENSG00000176884,Q05586,2,CHEMBL807,DB01043,Target,,Disease-modifying,
MONDO_0004976,IMPDH2,ENSG00000178035,P12268,2,CHEMBL1456,DB00688,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,S1PR5,ENSG00000180739,Q9H228,2,"CHEMBL314854, CHEMBL544665	",DB08868,Target,Modulator: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,GRIN2A,ENSG00000183454,Q12879,2,"CHEMBL807, CHEMBL52440","DB01043, DB00514",,,Both,
MONDO_0004976,SCN5A,ENSG00000183873,Q14524,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Both,
EFO_0001357,SCN10A,ENSG00000185313,Q9Y5Y9,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,
MONDO_0004976,PDE4B,ENSG00000184588,Q07343,2,CHEMBL19449,DB05266,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,MC2R,ENSG00000185231,Q01718,2,CHEMBL1201610,,,Agonist,Disease-modifying,
MONDO_0004976,TUBB,ENSG00000196230,P07437,2,CHEMBL107,DB01394,Target,"Inhibitor, Binder: Drug interacts directly with the target as part of its mechanism of action",Disease-modifying,
MONDO_0008458,SCN8A,ENSG00000196876,Q9UQD0,4,"CHEMBL744, CHEMBL1294, CHEMBL558, CHEMBL3707183        ","DB00740, DB00908, DB00379",,,Both,
MONDO_0004976,GRIN3A,ENSG00000198785,Q8TCU5,2,CHEMBL807,DB01043,,,Disease-modifying,
MONDO_0004976,S1PR3,ENSG00000213694,Q99500,2,"CHEMBL314854, CHEMBL544665	",DB08868,Target,Modulator: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0004976,S1PR2,ENSG00000267534,O95136,2,"CHEMBL314854, CHEMBL544665	",DB08868,,,Disease-modifying,
MONDO_0004976,GRIN2B,ENSG00000273079,Q13224,2,CHEMBL807,DB01043,,,Disease-modifying,
MONDO_0004976,SRD5A2,ENSG00000277893,P31213,2,CHEMBL1200969,DB01126,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,