diseaseId,targetId_genename,targetId,targetFromSourceId,Max Completed Clinical Phase,Associated drugId(s),drugbank,Target/Enzyme/Transporter,Pharmacological action,Therapeutic Intent,Notes
MONDO_0005180,MPO,ENSG00000005381,P05164,2,CHEMBL4297594,DB12440,Target,Unknown,Disease-modifying,
MONDO_0005180,SCN4A,ENSG00000007314,P35499,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GABRA3,ENSG00000011677,P34903,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,NR1H4,ENSG00000012504,Q96RI1,2,CHEMBL1551,DB01586,Target,Partial agnoist,Disease-modifying,
MONDO_0005180,GABRA1,ENSG00000022355,P14867,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ADRB1,ENSG00000043591,P08588,3,"CHEMBL59, CHEMBL1557        ","DB00988, DB01037",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,MAOB,ENSG00000069535,P27338,4,"CHEMBL972, CHEMBL887, CHEMBL396778","DB01037, DB01367, DB06654",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,DRD4,ENSG00000069696,P21917,4,"CHEMBL301265, CHEMBL493, CHEMBL1303, CHEMBL589, CHEMBL3182733, CHEMBL53, CHEMBL1200503, CHEMBL1200411, CHEMBL5314363, CHEMBL531, CHEMBL2146110, CHEMBL220808","DB00413, DB01200, DB05271, DB00268, DB00714, DB01186, DB06454",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,CACNA1S,ENSG00000081248,Q13698,3,CHEMBL1648,DB00270,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,No benefit in human trials
MONDO_0005180,OPRK1,ENSG00000082556,P41145,3,CHEMBL80,DB01183,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ACHE,ENSG00000087085,P22303,4,"CHEMBL636, CHEMBL812, CHEMBL502, CHEMBL1115","DB00989, DB00843, DB00545",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ESR1,ENSG00000091831,P03372,2,CHEMBL1201649,,,Agonist,Disease-modifying,
MONDO_0005180,COMT,ENSG00000093010,P21964,4,"CHEMBL953, CHEMBL1324, CHEMBL1089318, CHEMBL160038","DB00494, DB00323, DB11632, DB14849",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GABRP,ENSG00000094755,O00591,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ABL1,ENSG00000097007,P00519,2,CHEMBL255863,DB04868,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0005180,HRH3,ENSG00000101180,Q9Y5N1,3,CHEMBL462605,DB11642,Target,"Agonist, Inverse agonist: Drug interacts directly with the target as part of its mechanism of action",Symptomatic,
MONDO_0005180,CHRNA4,ENSG00000101204,P43681,2,"CHEMBL3, CHEMBL1076903	",DB00184,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Both,
MONDO_0005180,CACNA1F,ENSG00000102001,O60840,3,CHEMBL1648,DB00270,,Blocker,Disease-modifying,
MONDO_0005180,GABRE,ENSG00000102287,P78334,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,HTR2A,ENSG00000102468,P28223,4,"CHEMBL2448613, CHEMBL2111101",DB05316,Target,Inverse agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,SLC6A2,ENSG00000103546,P23975,4,"CHEMBL1201023, CHEMBL1201066, CHEMBL3989690, CHEMBL637, CHEMBL1175","DB06156, DB00285, DB00476",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Both,
MONDO_0005180,GRIN2D,ENSG00000105464,O15399,4,"CHEMBL660, CHEMBL1569, CHEMBL1201023,  CHEMBL807","DB00915, DB01043",,,Symptomatic,
MONDO_0005180,SLC6A4,ENSG00000108576,P31645,3,"CHEMBL1175, CHEMBL490, CHEMBL637, CHEMBL1201066, CHEMBL3989690","DB00476, DB00715, DB00285, DB06156",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Both,
MONDO_0005180,GABRA4,ENSG00000109158,P48169,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,VDR,ENSG00000111424,P11473,2,CHEMBL1042,DB00169,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,OPRM1,ENSG00000112038,P35372,3,"CHEMBL656, CHEMBL80","DB00497, DB01183",Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,HMGCR,ENSG00000113161,P04035,2,CHEMBL1064,DB00641,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,Ineffective in trials
MONDO_0005180,GABRG2,ENSG00000113327,P18507,2,"CHEMBL911, CHEMBL4105630","DB00425, DB15490",Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,BCHE,ENSG00000114200,P06276,4,"CHEMBL636, CHEMBL215645",DB00989,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,OPRD1,ENSG00000116329,P41143,3,CHEMBL80,DB01183,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0005180,GRIN3B,ENSG00000116032,O60391,4,"CHEMBL660, CHEMBL1569, CHEMBL1201023, CHEMBL807","DB00915, DB01043",,,Both,"(DB01043 currently in phase 3, recruiting for disease-modifying)"
MONDO_0005180,GLP1R,ENSG00000112164,P43220,2,"CHEMBL414357, CHEMBL4084119, CHEMBL2108336",,,Agonist,Disease-modifying,CHEMBL414357 failed to demonstrate disease-modifying
MONDO_0005180,CNR1,ENSG00000118432,P21554,3,CHEMBL190461,DB09061,Target,"Antagonist, Modulator: Drug interacts directly with the target as part of its mechanism of action",Symptomatic,
MONDO_0005180,GRIA2,ENSG00000120251,P42262,3,"CHEMBL1214124, CHEMBL61872","DB08883, DB04982",Target,Inhibitor,Both,(DB04982 for disease-modifying phase 2)
MONDO_0005180,GRM4,ENSG00000124493,Q14833,2,CHEMBL4089083,DB15292,Target,positive allosteric modulator or agonist,Symptomatic,
MONDO_0005180,OPRL1,ENSG00000125510,P41146,2,CHEMBL3304244,DB16048,Target,Modulator,Symptomatic,
MONDO_0005180,GRIA3,ENSG00000125675,P42263,3,CHEMBL1214124,DB08883,Target,Unknown,Symptomatic,
MONDO_0005180,ADORA2A,ENSG00000128271,P29274,4,"CHEMBL431770, CHEMBL447664, CHEMBL113, CHEMBL2105747, CHEMBL240624","DB11757, DB06625, DB00201, DB12203, DB11864",Target,"Antagonist, Modulator: Drug interacts directly with the target as part of its mechanism of action",Symptomatic,
MONDO_0005180,PPARG,ENSG00000132170,P37231,2,CHEMBL595,DB01132,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,(These findings suggest that pioglitazone at the doses studied here is unlikely to modify progression in early Parkinson's disease)
MONDO_0005180,DDC,ENSG00000132437,P20711,4,"CHEMBL1200748, CHEMBL1201236, CHEMBL1096979","DB00190, DB12783",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,SNAP25,ENSG00000132639,P60880,3,"CHEMBL2108035, CHEMBL1201574",,,Inhibitor,Symptomatic,
MONDO_0005180,CHRM3,ENSG00000133019,P20309,4,"CHEMBL2146146, CHEMBL1621597, CHEMBL2134724, CHEMBL1200604","DB00332, DB00809",Target,"Antagonist, Modulator: Drug interacts directly with the target as part of its mechanism of action",Both,
MONDO_0005180,SCN2A,ENSG00000136531,Q99250,4,CHEMBL1201023,,,Blocker,Symptomatic,
MONDO_0005180,GABBR2,ENSG00000136928,O75899,2,"CHEMBL1200682, CHEMBL1342","DB09072, DB01440",Target,Agonist,Both,
MONDO_0005180,ESR2,ENSG00000140009,Q92731,2,CHEMBL1201649,,,Agonist,Symptomatic,
MONDO_0005180,SLC6A3,ENSG00000142319,Q01959,2,"CHEMBL796, CHEMBL1373, CHEMBL3989690","DB00422, DB00745, DB06156",Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Both,(DB06156 evaluated for disease-modifying)
MONDO_0005180,SCN1A,ENSG00000144285,P35498,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GABRA6,ENSG00000145863,Q16445,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GABRB2,ENSG00000145864,P47870,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,HTR2C,ENSG00000147246,P28335,4,CHEMBL1201342,DB00340,,Antagonist,Disease-modifying,
MONDO_0005180,SIGMAR1,ENSG00000147955,Q99720,2,CHEMBL52440,DB00514,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,CACNA1B,ENSG00000148408,Q00975,2,CHEMBL1286,DB01202,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ADRA2A,ENSG00000150594,P08913,2,CHEMBL1255582,DB06585,Target,Antagonist,Symptomatic,
MONDO_0005180,CACNA1C,ENSG00000151067,Q13936,3,CHEMBL1648,DB00270,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Disease-modifying,
MONDO_0005180,DRD2,ENSG00000149295,P14416,4,"CHEMBL589, CHEMBL419792, CHEMBL301265, CHEMBL1303, CHEMBL2103832, CHEMBL219916, CHEMBL531, CHEMBL493, CHEMBL53, CHEMBL1201087, CHEMBL2110659, CHEMBL220808, CHEMBL5314363, CHEMBL1200411, CHEMBL1200503, CHEMBL3182733, CHEMBL2146110        ","DB00268, DB06477, DB00413, DB05271, DB12061, DB01184, DB01186, DB01200, DB00714, DB00248, DB06620, DB06454",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,DRD3,ENSG00000151577,P35462,4,"CHEMBL301265, CHEMBL1009, CHEMBL589, CHEMBL2103832, CHEMBL1303, CHEMBL53, CHEMBL531, CHEMBL493, CHEMBL1009, CHEMBL4594447, CHEMBL220808, CHEMBL5314363, CHEMBL3182733, CHEMBL1200411, CHEMBL2146110, CHEMBL1200503                      ","DB00413, DB01235, DB00268, DB12061, DB05271, DB00714, DB01186, DB01200, DB01235, DB16229, DB06454",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Both,(DB00413 and DB16229 investiged for disease modifying potential)
MONDO_0005180,NR3C2,ENSG00000151623,P08235,2,CHEMBL1201010,,,Agonist,Symptomatic,
MONDO_0005180,GABRA2,ENSG00000151834,P47869,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GRIA4,ENSG00000152578,P48058,3,CHEMBL1214124,DB08883,Target,Unknown,Symptomatic,
MONDO_0005180,SCN3A,ENSG00000153253,Q9NY46,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GRIA1,ENSG00000155511,P42261,2,CHEMBL61872,DB04982,Target,Unknown,Symptomatic,
MONDO_0005180,CACNA1D,ENSG00000157388,Q01668,3,CHEMBL1648,DB00270,Target,Inhibitor: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,(DB00270 has been investigated for disease-modifying)
MONDO_0005180,SV2A,ENSG00000159164,Q7L0J3,2,CHEMBL1286,DB01202,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,CHRNB2,ENSG00000160716,P17787,2,CHEMBL3,DB00184,Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Both,
MONDO_0005180,GRIN2C,ENSG00000161509,Q14957,4,"CHEMBL660, CHEMBL807, CHEMBL1569, CHEMBL1201023        ","DB00915, DB01043",Target,Antagonist,Symptomatic,
MONDO_0005180,GABRG1,ENSG00000163285,Q8N1C3,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GABRB1,ENSG00000163288,P18505,2,"CHEMBL911, CHEMBL4105630","DB00425, DB15490",Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,ADORA1,ENSG00000163485,P30542,3,CHEMBL113,DB00201,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GABRB3,ENSG00000166206,P28472,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,SCN11A,ENSG00000168356,Q9UI33,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GRM5,ENSG00000168959,P41594,2,"CHEMBL3087515, CHEMBL2346738","DB13004, DB12733",Target,Modulator,Symptomatic,
MONDO_0005180,SCN9A,ENSG00000169432,Q15858,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,DRD5,ENSG00000169676,P21918,4,"CHEMBL531, CHEMBL3697617","DB01186, DB14899",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,INSR,ENSG00000171105,P06213,2,CHEMBL1201631,,,Agonist,Disease-modifying,
MONDO_0005180,ADORA2B,ENSG00000170425,P29275,3,CHEMBL113,DB00201,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,CHRM1,ENSG00000168539,P11229,4,"CHEMBL1201203, CHEMBL1101, CHEMBL86715, CHEMBL1490, CHEMBL1201342, CHEMBL2146146, CHEMBL1206, CHEMBL1200383, CHEMBL4594351","DB00245, DB00810, DB00392, DB00387, DB00376, DB00340",Target,Modulator,Both,(CHEMBL2146146 has been in DMT investigations; CHEMBL4594351 targeting disease-mechanisms)
MONDO_0005180,GRIN1,ENSG00000176884,Q05586,4,"CHEMBL660, CHEMBL807, CHEMBL1569, CHEMBL1201023, CHEMBL17350","DB00915, DB01043",Target,Binder: This is a potential target. There are limited data regarding this target in the literature.,Both,(CHEMBL17350 investigated as disease-modifying in phase 2)       
MONDO_0005180,HTR1A,ENSG00000178394,P08908,3,"CHEMBL49, CHEMBL2103832, CHEMBL220808, CHEMBL345237, CHEMBL2146110       ","DB00490, DB12061, DB06454, DB12361",Target,Partial agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,NQO1,ENSG00000181019,P15559,2,CHEMBL1812161,DB11917,,Modulator,Symptomatic,
MONDO_0005180,CHRM2,ENSG00000181072,P08172,4,CHEMBL2146146,,,Antagonist,Both,(CHEMBL2146146 has been in DMT investigations)
MONDO_0005180,GABRG3,ENSG00000182256,Q99928,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,SCN5A,ENSG00000183873,Q14524,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,ADRA2C,ENSG00000184160,P18825,2,CHEMBL1255582,DB06585,Target,Antagonist,Symptomatic,
MONDO_0005180,GRIN2A,ENSG00000183454,Q12879,4,"CHEMBL660, CHEMBL1569, CHEMBL807, CHEMBL52440, CHEMBL1201023        ","DB00915, DB01043, DB00514",,,Symptomatic,
MONDO_0005180,DRD1,ENSG00000184845,P21728,4,"CHEMBL531, CHEMBL3697617","DB01186, DB14899",Target,Agonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,SCN10A,ENSG00000185313,Q9Y5Y9,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GABRA5,ENSG00000186297,P31644,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,BCR,ENSG00000186716,P11274,2,CHEMBL255863,DB04868,Target (BCR-ABL fusion protein),,Disease-modifying,
MONDO_0005180,GABRD,ENSG00000187730,O14764,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,HRH1,ENSG00000196639,P35367,4,CHEMBL1201023,,,Antagonist,Symptomatic,
MONDO_0005180,SCN8A,ENSG00000196876,Q9UQD0,4,CHEMBL1201023,,,,Symptomatic,
MONDO_0005180,GRIN3A,ENSG00000198785,Q8TCU5,4,"CHEMBL660, CHEMBL1569, CHEMBL807, CHEMBL1201023        ","DB00915, DB01043",Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GABBR1,ENSG00000204681,Q9UBS5,2,CHEMBL1342,"DB01440, DB09072",Target,Agonist,Symptomatic,
MONDO_0005180,GABRQ,ENSG00000268089,Q9UN88,2,CHEMBL4105630,DB15490,Target,Positive allosteric modulator: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,
MONDO_0005180,GRIN2B,ENSG00000273079,Q13224,4,"CHEMBL660, CHEMBL1569, CHEMBL807, CHEMBL1201023, CHEMBL17350       ","DB00915, DB01043",,,Symptomatic,
MONDO_0005180,ADRA2B,ENSG00000274286,P18089,2,CHEMBL1255582,DB06585,Target,Antagonist,Symptomatic,
MONDO_0005180,ADORA3,ENSG00000282608,P0DMS8,2,CHEMBL113,DB00201,Target,Antagonist: Drug interacts directly with the target as part of its mechanism of action,Symptomatic,