Assay
type: Class
comment: A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.[OBI_0000070]
subclass of: Thing
is part of: schema.biothings.io
display name: Assay
required: sms:false

Device
type: Class
comment: A thing made or adapted for a particular purpose, especially a piece of mechanical or electronic equipment
subclass of: Assay
is part of: schema.biothings.io
display name: Device
required: sms:false

Sequencing
type: Class
comment: Module for next generation sequencing assays
subclass of: Assay
is part of: schema.biothings.io
display name: Sequencing
required: sms:false

Component
type: Class
comment: Category of metadata (e.g. Diagnosis, Biospecimen, scRNA-seq Level 1, etc.); provide the same one for all items/rows.
subclass of: Thing
is part of: schema.biothings.io
display name: Component
required: sms:true

Patient
type: Class
comment: HTAN patient
subclass of: IndividualOrganism
is part of: schema.biothings.io
display name: Patient
required: sms:false
requires component: Demographics
requires component: FamilyHistory
requires component: Exposure
requires component: FollowUp
requires component: Diagnosis
requires component: Therapy
requires component: MolecularTest
requires dependency: Component
requires dependency: HTANParticipantID

HTANParticipantID
type: Class
comment: HTAN ID associated with a patient based on HTAN ID SOP (eg HTANx_yyy )
subclass of: Patient
is part of: schema.biothings.io
display name: HTAN Participant ID
required: sms:true
validation rules: regex match ^(HTA([1-9]|1[0-6]))_((EXT)?([0-9]\d*|0000))$ warning

Demographics
type: Class
comment: Demographic attributes
subclass of: Patient
is part of: schema.biothings.io
display name: Demographics
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: Ethnicity
requires dependency: Gender
requires dependency: Race
requires dependency: VitalStatus
requires dependency: DaystoBirth
requires dependency: CountryofResidence
requires dependency: AgeIsObfuscated
requires dependency: YearOfBirth
requires dependency: OccupationDurationYears
requires dependency: PrematureAtBirth
requires dependency: WeeksGestationatBirth

FamilyHistory
type: Class
comment: Family cancer history
subclass of: Patient
is part of: schema.biothings.io
display name: Family History
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: RelativewithCancerHistory

Exposure
type: Class
comment: Exposure to carcinogens
subclass of: Patient
is part of: schema.biothings.io
display name: Exposure
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: StartDaysfromIndex
requires dependency: SmokingExposure
requires dependency: AlcoholExposure
requires dependency: AsbestosExposure
requires dependency: CoalDustExposure
requires dependency: EnvironmentalTobaccoSmokeExposure
requires dependency: RadonExposure
requires dependency: RespirableCrystallineSilicaExposure

FollowUp
type: Class
comment: Follow up clinical visits
subclass of: Patient
is part of: schema.biothings.io
display name: Follow Up
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: DaystoFollowUp
requires dependency: AdverseEvent
requires dependency: ProgressionorRecurrence
requires dependency: BarrettsEsophagusGobletCellsPresent
requires dependency: BMI
requires dependency: CauseofResponse
requires dependency: Comorbidity
requires dependency: ComorbidityMethodofDiagnosis
requires dependency: DaystoAdverseEvent
requires dependency: DaystoComorbidity
requires dependency: DiabetesTreatmentType
requires dependency: DiseaseResponse
requires dependency: DLCORefPredictivePercent
requires dependency: ECOGPerformanceStatus
requires dependency: FEV1FVCPostBronchPercent
requires dependency: FEV1FVCPreBronchPercent
requires dependency: FEV1RefPostBronchPercent
requires dependency: FEV1RefPreBronchPercent
requires dependency: Height
requires dependency: HepatitisSustainedVirologicalResponse
requires dependency: HPVPositiveType
requires dependency: KarnofskyPerformanceStatus
requires dependency: MenopauseStatus
requires dependency: PancreatitisOnsetYear
requires dependency: RefluxTreatmentType
requires dependency: RiskFactor
requires dependency: RiskFactorTreatment
requires dependency: ViralHepatitisSerologies
requires dependency: Weight
requires dependency: AdverseEventGrade
requires dependency: AIDSRiskFactors
requires dependency: BodySurfaceArea
requires dependency: CD4Count
requires dependency: CDCHIVRiskFactors
requires dependency: DaystoImaging
requires dependency: EvidenceofRecurrenceType
requires dependency: HAARTTreatmentIndicator
requires dependency: HIVViralLoad
requires dependency: HormonalContraceptiveUse
requires dependency: HysterectomyMarginsInvolved
requires dependency: HysterectomyType
requires dependency: ImagingResult
requires dependency: ImagingType
requires dependency: ImmunosuppressiveTreatmentType
requires dependency: NadirCD4Count
requires dependency: PregnancyOutcome
requires dependency: RecistTargetedRegionsNumber
requires dependency: RecistTargetedRegionsSum
requires dependency: ScanTracerUsed

Diagnosis
type: Class
comment: Disease diagnosis
subclass of: Patient
is part of: schema.biothings.io
display name: Diagnosis
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: AgeatDiagnosis
requires dependency: YearofDiagnosis
requires dependency: PrimaryDiagnosis
requires dependency: PrecancerousConditionType
requires dependency: SiteofResectionorBiopsy
requires dependency: TissueorOrganofOrigin
requires dependency: Morphology
requires dependency: TumorGrade
requires dependency: ProgressionorRecurrence
requires dependency: LastKnownDiseaseStatus
requires dependency: DaystoLastFollowup
requires dependency: DaystoLastKnownDiseaseStatus
requires dependency: MethodofDiagnosis
requires dependency: PriorMalignancy
requires dependency: PriorTreatment
requires dependency: MetastasisatDiagnosis
requires dependency: MetastasisatDiagnosisSite
requires dependency: FirstSymptomPriortoDiagnosis
requires dependency: DaystoDiagnosis
requires dependency: PercentTumorInvasion
requires dependency: ResidualDisease
requires dependency: SynchronousMalignancy
requires dependency: TumorConfinedtoOrganofOrigin
requires dependency: TumorFocality
requires dependency: TumorLargestDimensionDiameter
requires dependency: GrossTumorWeight
requires dependency: BreslowThickness
requires dependency: VascularInvasionPresent
requires dependency: VascularInvasionType
requires dependency: AnaplasiaPresent
requires dependency: AnaplasiaPresentType
requires dependency: Laterality
requires dependency: PerineuralInvasionPresent
requires dependency: LymphaticInvasionPresent
requires dependency: LymphNodesPositive
requires dependency: LymphNodesTested
requires dependency: PeritonealFluidCytologicalStatus
requires dependency: ClassificationofTumor
requires dependency: BestOverallResponse
requires dependency: MitoticCount
requires dependency: AJCCClinicalM
requires dependency: AJCCClinicalN
requires dependency: AJCCClinicalStage
requires dependency: AJCCClinicalT
requires dependency: AJCCPathologicM
requires dependency: AJCCPathologicN
requires dependency: AJCCPathologicStage
requires dependency: AJCCPathologicT
requires dependency: AJCCStagingSystemEdition
requires dependency: CogNeuroblastomaRiskGroup
requires dependency: CogRhabdomyosarcomaRiskGroup
requires dependency: GleasonGradeGroup
requires dependency: GleasonGradeTertiary
requires dependency: GleasonPatternsPercent
requires dependency: GreatestTumorDimension
requires dependency: IGCCCGStage
requires dependency: INPCGrade
requires dependency: INPCHistologicGroup
requires dependency: INRGStage
requires dependency: INSSStage
requires dependency: InternationalPrognosticIndex
requires dependency: IRSGroup
requires dependency: IRSStage
requires dependency: ISSStage
requires dependency: LymphNodeInvolvedSite
requires dependency: MarginDistance
requires dependency: MarginsInvolvedSite
requires dependency: MedulloblastomaMolecularClassification
requires dependency: MicropapillaryFeatures
requires dependency: MitosisKaryorrhexisIndex
requires dependency: NonNodalRegionalDisease

Therapy
type: Class
comment: Clinical therapy or treatment
subclass of: Patient
is part of: schema.biothings.io
display name: Therapy
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TreatmentorTherapy
requires dependency: TreatmentType
requires dependency: TreatmentEffect
requires dependency: TreatmentOutcome
requires dependency: DaystoTreatmentEnd
requires dependency: TreatmentAnatomicSite
requires dependency: DaystoTreatmentStart
requires dependency: InitialDiseaseStatus
requires dependency: RegimenorLineofTherapy
requires dependency: TherapeuticAgents
requires dependency: TreatmentIntentType
requires dependency: ChemoConcurrenttoRadiation
requires dependency: NumberofCycles
requires dependency: ReasonTreatmentEnded
requires dependency: TreatmentArm
requires dependency: TreatmentDose
requires dependency: TreatmentDoseUnits
requires dependency: TreatmentEffectIndicator
requires dependency: TreatmentFrequency

MolecularTest
type: Class
comment: Clinical molecular test data
subclass of: Patient
is part of: schema.biothings.io
display name: Molecular Test
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: GeneSymbol
requires dependency: MolecularAnalysisMethod
requires dependency: TestResult
requires dependency: AAChange
requires dependency: Antigen
requires dependency: ClinicalBiospecimenType
requires dependency: BloodTestNormalRangeUpper
requires dependency: BloodTestNormalRangeLower
requires dependency: CellCount
requires dependency: Chromosome
requires dependency: Clonality
requires dependency: CopyNumber
requires dependency: Cytoband
requires dependency: Exon
requires dependency: HistoneFamily
requires dependency: HistoneVariant
requires dependency: Intron
requires dependency: LaboratoryTest
requires dependency: LociAbnormalCount
requires dependency: LociCount
requires dependency: Locus
requires dependency: MismatchRepairMutation
requires dependency: MolecularConsequence
requires dependency: Pathogenicity
requires dependency: Ploidy
requires dependency: SecondExon
requires dependency: SecondGeneSymbol
requires dependency: SpecializedMolecularTest
requires dependency: TestAnalyteType
requires dependency: TestUnits
requires dependency: TestValue
requires dependency: Transcript
requires dependency: VariantOrigin
requires dependency: VariantType
requires dependency: Zygosity

IndividualOrganism
type: Class
comment: TBD
subclass of: Thing
is part of: schema.biothings.io
display name: Individual Organism
required: sms:false

File
type: Class
comment: A type of Information Content Entity specific to OS
subclass of: InformationContentEntity
is part of: schema.biothings.io
display name: File
required: sms:false

InformationContentEntity
type: Class
comment: TBD
subclass of: Thing
is part of: schema.biothings.io
display name: Information Content Entity
required: sms:false

Filename
type: Class
comment: Name of a file
subclass of: Thing
is part of: schema.biothings.io
display name: Filename
required: sms:true
validation rules: regex search ^.+\/\S*$

FileFormat
type: Class
comment: Format of a file (e.g. txt, csv, fastq, bam, etc.)
subclass of: Thing
is part of: schema.biothings.io
range includes: Hdf5
range includes: Bedgraph
range includes: Idx
range includes: Idat
range includes: Bam
range includes: Bai
range includes: Excel
range includes: Powerpoint
range includes: Tif
range includes: Tiff
range includes: OME-TIFF
range includes: Png
range includes: Doc
range includes: Pdf
range includes: Fasta
range includes: Fastq
range includes: Sam
range includes: Vcf
range includes: Bcf
range includes: Maf
range includes: Bed
range includes: Chp
range includes: Cel
range includes: Sif
range includes: Tsv
range includes: Csv
range includes: Txt
range includes: Plink
range includes: Bigwig
range includes: Wiggle
range includes: Gct
range includes: Bgzip
range includes: Zip
range includes: Seg
range includes: Html
range includes: Mov
range includes: Hyperlink
range includes: Svs
range includes: Md
range includes: Flagstat
range includes: Gtf
range includes: Raw
range includes: Msf
range includes: Rmd
range includes: BednarrowPeak
range includes: BedbroadPeak
range includes: BedgappedPeak
range includes: Avi
range includes: Pzfx
range includes: Fig
range includes: Xml
range includes: Tar
range includes: Rscript
range includes: Abf
range includes: Bpm
range includes: Dat
range includes: Jpg
range includes: Locs
range includes: Sentrixdescriptorfile
range includes: Pythonscript
range includes: Sav
range includes: Gzip
range includes: Sdf
range includes: RData
range includes: Hic
range includes: Ab1
range includes: 7z
range includes: Gff3
range includes: Json
range includes: Sqlite
range includes: Svg
range includes: Sra
range includes: Recal
range includes: Tranches
range includes: Mtx

Hdf5
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: hdf5
required: sms:false

Bedgraph
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bedgraph
required: sms:false

Idx
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: idx
required: sms:false

Idat
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: idat
required: sms:false

Bam
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bam
required: sms:false

Bai
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bai
required: sms:false

Excel
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: excel
required: sms:false

Powerpoint
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: powerpoint
required: sms:false

Tif
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tif
required: sms:false

Tiff
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tiff
required: sms:false

OME-TIFF
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: OME-TIFF
required: sms:false

Png
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: png
required: sms:false

Doc
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: doc
required: sms:false

Pdf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: pdf
required: sms:false

Fasta
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: fasta
required: sms:false

Fastq
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: fastq
required: sms:false

Sam
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sam
required: sms:false

Vcf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: vcf
required: sms:false

Bcf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bcf
required: sms:false

Maf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: maf
required: sms:false

Bed
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bed
required: sms:false

Chp
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: chp
required: sms:false

Cel
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: cel
required: sms:false

Sif
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sif
required: sms:false

Tsv
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tsv
required: sms:false

Csv
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: csv
required: sms:false

Txt
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: txt
required: sms:false

Plink
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: plink
required: sms:false

Bigwig
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bigwig
required: sms:false

Wiggle
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: wiggle
required: sms:false

Gct
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: gct
required: sms:false

Bgzip
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bgzip
required: sms:false

Zip
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: zip
required: sms:false

Seg
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: seg
required: sms:false

Html
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: html
required: sms:false

Mov
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: mov
required: sms:false

Hyperlink
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: hyperlink
required: sms:false

Svs
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: svs
required: sms:false

Md
type: Class
comment: TBD
subclass of: FileFormat
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Md
required: sms:false

Flagstat
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: flagstat
required: sms:false

Gtf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: gtf
required: sms:false

Raw
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: raw
required: sms:false

Msf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: msf
required: sms:false

Rmd
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: rmd
required: sms:false

BednarrowPeak
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bed narrowPeak
required: sms:false

BedbroadPeak
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bed broadPeak
required: sms:false

BedgappedPeak
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bed gappedPeak
required: sms:false

Avi
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: avi
required: sms:false

Pzfx
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: pzfx
required: sms:false

Fig
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: fig
required: sms:false

Xml
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: xml
required: sms:false

Tar
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tar
required: sms:false

Rscript
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: R script
required: sms:false

Abf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: abf
required: sms:false

Bpm
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bpm
required: sms:false

Dat
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: dat
required: sms:false

Jpg
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: jpg
required: sms:false

Locs
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: locs
required: sms:false

Sentrixdescriptorfile
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: Sentrix descriptor file
required: sms:false

Pythonscript
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: Python script
required: sms:false

Sav
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sav
required: sms:false

Gzip
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: gzip
required: sms:false

Sdf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sdf
required: sms:false

RData
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: RData
required: sms:false

Hic
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: hic
required: sms:false

Ab1
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: ab1
required: sms:false

7z
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: 7z
required: sms:false

Gff3
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: gff3
required: sms:false

Json
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: json
required: sms:false

Sqlite
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sqlite
required: sms:false

Svg
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: svg
required: sms:false

Sra
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sra
required: sms:false

Recal
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: recal
required: sms:false

Tranches
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tranches
required: sms:false

Mtx
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: mtx
required: sms:false

TagAlign
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: tagAlign
required: sms:false

Dup
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: dup
required: sms:false

DICOM
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: DICOM
required: sms:false

Czi
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: czi
required: sms:false

Mex
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: mex
required: sms:false

Cloupe
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: cloupe
required: sms:false

Am
type: Class
comment: TBD
subclass of: FileFormat
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Am
required: sms:false

Cellam
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: cell am
required: sms:false

Mpg
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: mpg
required: sms:false

M
type: Class
comment: TBD
subclass of: INRGStage
subclass of: FileFormat
is part of: schema.biothings.io
display name: M
required: sms:false

MzML
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: mzML
required: sms:false

Scn
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: scn
required: sms:false

Dcc
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: dcc
required: sms:false

Rcc
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: rcc
required: sms:false

Pkc
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: pkc
required: sms:false

Sf
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: sf
required: sms:false

Bedpe
type: Class
comment: TBD
subclass of: FileFormat
is part of: schema.biothings.io
display name: bedpe
required: sms:false

CDSSequencingTemplate
type: Class
comment: CDS compatible template file, includes attributes for Genomic Reference, Library Layout, Data Type, Sequencing Platform, Library Selection Method
subclass of: Thing
is part of: schema.biothings.io
display name: CDS Sequencing Template
required: sms:true
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: CDSlibraryId
requires dependency: CDSlibraryStrategy
requires dependency: CDSlibrarySource
requires dependency: CDSlibrarySelection
requires dependency: CDSlibraryLayout
requires dependency: CDSplatform
requires dependency: CDSinstrumentModel
requires dependency: CDSdesignDescription
requires dependency: CDSreferenceGenomeAssembly
requires dependency: CDScustomAssemblyFastaFileForAlignment
requires dependency: CDSbases
requires dependency: CDSnumberOfReads
requires dependency: CDScoverage
requires dependency: CDSavgReadLength
requires dependency: CDSsequenceAlignmentSoftware

HTANDataFileID
type: Class
comment: Self-identifier for this data file - HTAN ID of this file HTAN ID SOP (eg HTANx_yyy_zzz)
subclass of: File
is part of: schema.biothings.io
display name: HTAN Data File ID
required: sms:true
validation rules: regex match ^(HTA([1-9]|1[0-6]))_((EXT)?([0-9]\d*|0000))_([0-9]\d*|0000)$ warning

HTANParentBiospecimenID
type: Class
comment: HTAN Biospecimen Identifier (eg HTANx_yyy_zzz) indicating the biospecimen(s) from which these files were derived; multiple parent biospecimen should be comma-separated
subclass of: Biospecimen
is part of: schema.biothings.io
display name: HTAN Parent Biospecimen ID
required: sms:true

CDSlibraryId
type: Class
comment: Short unique identifier for the sequencing library.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS library_id
required: sms:true
validation rules: str

CDSlibraryStrategy
type: Class
comment: Library strategy
subclass of: Sequencing
is part of: schema.biothings.io
range includes: AMPLICON
range includes: ATAC-seq
range includes: Bisulfite-Seq
range includes: ChIA-PET
range includes: ChIP-Seq
range includes: CLONE
range includes: CLONEEND
range includes: CTS
range includes: DNase-Hypersensitivity
range includes: EST
range includes: FAIRE-seq
range includes: FINISHING
range includes: FL-cDNA
range includes: Hi-C
range includes: MBD-Seq
range includes: MeDIP-Seq
range includes: MiRNA-Seq
range includes: MNase-Seq
range includes: MRE-Seq
range includes: NcRNA-Seq
range includes: OTHER
range includes: POOLCLONE
range includes: RAD-Seq
range includes: RIP-Seq
range includes: RNA-Seq
range includes: SELEX
range includes: SsRNA-seq
range includes: Synthetic-Long-Read
range includes: Targeted-Capture
range includes: TetheredChromatinConformationCapture
range includes: Tn-Seq
range includes: WCS
range includes: WGA
range includes: WGS
range includes: WXS
display name: CDS library_strategy
required: sms:true
validation rules: str

CDSlibrarySource
type: Class
comment: The Library Source specifies the type of source material that is being sequenced
subclass of: Sequencing
is part of: schema.biothings.io
range includes: GENOMIC
range includes: GENOMICSINGLECELL
range includes: METAGENOMIC
range includes: METATRANSCRIPTOMIC
range includes: OTHER
range includes: SYNTHETIC
range includes: TRANSCRIPTOMIC
range includes: TRANSCRIPTOMICSINGLECELL
range includes: VIRALRNA
display name: CDS library_source
required: sms:true
validation rules: str

CDSlibrarySelection
type: Class
comment: Library Selection Method
subclass of: Sequencing
is part of: schema.biothings.io
range includes: 5-methylcytidineantibody
range includes: CAGE
range includes: CDNA
range includes: CDNAOligoDT
range includes: CDNARandomPriming
range includes: CF-H
range includes: CF-M
range includes: CF-S
range includes: CF-T
range includes: ChIP
range includes: DNAse
range includes: HMPR
range includes: HybridSelection
range includes: InverserRNA
range includes: MBD2proteinmethyl-CpGbindingdomain
range includes: MDA
range includes: MF
range includes: MNase
range includes: MSLL
range includes: Oligo-dT
range includes: Other
range includes: Padlockprobescapturemethod
range includes: PCR
range includes: PolyA
range includes: RACE
range includes: RANDOM
range includes: RANDOMPCR
range includes: ReducedRepresentation
range includes: Repeatfractionation
range includes: RestrictionDigest
range includes: RT-PCR
range includes: Sizefractionation
range includes: Unspecified
display name: CDS library_selection
required: sms:true
validation rules: str

CDSlibraryLayout
type: Class
comment: Paired-end or Single
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Paired-end
range includes: Single-end
display name: CDS library_layout
required: sms:true
validation rules: str

CDSplatform
type: Class
comment: Sequencing Platform used for Sequencing
subclass of: Sequencing
is part of: schema.biothings.io
range includes: LS454
range includes: ABISOLID
range includes: BGISEQ
range includes: CAPILLARY
range includes: COMPLETEGENOMICS
range includes: HELICOS
range includes: ILLUMINA
range includes: IONTORRENT
range includes: OXFORDNANOPORE
range includes: PACBIOSMRT
display name: CDS platform
required: sms:true
validation rules: str

CDSinstrumentModel
type: Class
comment: Instrument model used for sequencing
subclass of: Sequencing
is part of: schema.biothings.io
range includes: 454GS
range includes: 454GS20
range includes: 454GSFLX
range includes: 454GSFLX+
range includes: 454GSFLXTitanium
range includes: 454GSJunior
range includes: HiSeqXFive
range includes: HiSeqXTen
range includes: IlluminaGenomeAnalyzer
range includes: IlluminaGenomeAnalyzerII
range includes: IlluminaGenomeAnalyzerIIx
range includes: IlluminaHiScanSQ
range includes: IlluminaHiSeq1000
range includes: IlluminaHiSeq1500
range includes: IlluminaHiSeq2000
range includes: IlluminaHiSeq2500
range includes: IlluminaHiSeq3000
range includes: IlluminaHiSeq4000
range includes: IlluminaiSeq100
range includes: IlluminaNovaSeq6000
range includes: IlluminaMiniSeq
range includes: IlluminaMiSeq
range includes: NextSeq500
range includes: NextSeq550
range includes: HelicosHeliScope
range includes: AB5500GeneticAnalyzer
range includes: AB5500xlGeneticAnalyzer
range includes: AB5500x-WlGeneticAnalyzer
range includes: ABSOLiD3PlusSystem
range includes: ABSOLiD4System
range includes: ABSOLiD4hqSystem
range includes: ABSOLiDPISystem
range includes: ABSOLiDSystem
range includes: ABSOLiDSystem2.0
range includes: ABSOLiDSystem3.0
range includes: CompleteGenomics
range includes: PacBioRS
range includes: PacBioRSII
range includes: PacBioSequel
range includes: PacBioSequelII
range includes: IonTorrentPGM
range includes: IonTorrentProton
range includes: IonTorrentS5XL
range includes: IonTorrentS5
range includes: AB310GeneticAnalyzer
range includes: AB3130GeneticAnalyzer
range includes: AB3130xLGeneticAnalyzer
range includes: AB3500GeneticAnalyzer
range includes: AB3500xLGeneticAnalyzer
range includes: AB3730GeneticAnalyzer
range includes: AB3730xLGeneticAnalyzer
range includes: GridION
range includes: MinION
range includes: PromethION
range includes: BGISEQ-500
range includes: DNBSEQ-G400
range includes: DNBSEQ-T7
range includes: DNBSEQ-G50
range includes: MGISEQ-2000RS
display name: CDS instrument_model
required: sms:true
validation rules: str

CDSdesignDescription
type: Class
comment: Free-form description of the methods used to create the sequencing library; a brief 'materials and methods' section.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS design_description
required: sms:false
validation rules: str

CDSreferenceGenomeAssembly
type: Class
comment: This is only if you are submitting a bam file aligned against a NCBI assembly.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS reference_genome_assembly
required: sms:false
validation rules: str

CDScustomAssemblyFastaFileForAlignment
type: Class
comment: Please provide the name of the custom assembly fasta file used during alignment
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS custom_assembly_fasta_file_for_alignment
required: sms:false
validation rules: str

CDSbases
type: Class
comment: Count of unique basecalls present in the data. Please count each base only once if using secondary alignments.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS bases
required: sms:false
validation rules: int

CDSnumberOfReads
type: Class
comment: Count of the number of reads in the data. Please count each read only once if using secondary alignments.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS number_of_reads
required: sms:false
validation rules: int

CDScoverage
type: Class
comment: Depth of coverage on assembly used. Found by (Unique Aligned Basecalls)/(Reference Length)
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS coverage
required: sms:false
validation rules: int

CDSavgReadLength
type: Class
comment: Found by (Bases)/(Reads)
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS avg_read_length
required: sms:false
validation rules: int

CDSsequenceAlignmentSoftware
type: Class
comment: The name of the software program used to align nucleotide sequencing data.
subclass of: Sequencing
is part of: schema.biothings.io
display name: CDS sequence_alignment_software
required: sms:false
validation rules: str

AMPLICON
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: AMPLICON
required: sms:false

ATAC-seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: ATAC-seq
required: sms:false

Bisulfite-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Bisulfite-Seq
required: sms:false

ChIA-PET
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: ChIA-PET
required: sms:false

ChIP-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: ChIP-Seq
required: sms:false

CLONE
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: CLONE
required: sms:false

CLONEEND
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: CLONEEND
required: sms:false

CTS
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: CTS
required: sms:false

DNase-Hypersensitivity
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: DNase-Hypersensitivity
required: sms:false

EST
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: EST
required: sms:false

FAIRE-seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: FAIRE-seq
required: sms:false

FINISHING
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: FINISHING
required: sms:false

FL-cDNA
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: FL-cDNA
required: sms:false

Hi-C
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Hi-C
required: sms:false

MBD-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: MBD-Seq
required: sms:false

MeDIP-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: MeDIP-Seq
required: sms:false

MiRNA-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: miRNA-Seq
required: sms:false

MNase-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: MNase-Seq
required: sms:false

MRE-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: MRE-Seq
required: sms:false

NcRNA-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: ncRNA-Seq
required: sms:false

OTHER
type: Class
comment: TBD
subclass of: CDSlibrarySource
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: OTHER
required: sms:false

POOLCLONE
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: POOLCLONE
required: sms:false

RAD-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: RAD-Seq
required: sms:false

RIP-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: RIP-Seq
required: sms:false

RNA-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: RNA-Seq
required: sms:false

SELEX
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: SELEX
required: sms:false

SsRNA-seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: ssRNA-seq
required: sms:false

Synthetic-Long-Read
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Synthetic-Long-Read
required: sms:false

Targeted-Capture
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Targeted-Capture
required: sms:false

TetheredChromatinConformationCapture
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Tethered Chromatin Conformation Capture
required: sms:false

Tn-Seq
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: Tn-Seq
required: sms:false

WCS
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: WCS
required: sms:false

WGA
type: Class
comment: TBD
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: WGA
required: sms:false

WGS
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: WGS
required: sms:false

WXS
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
subclass of: CDSlibraryStrategy
is part of: schema.biothings.io
display name: WXS
required: sms:false

GENOMIC
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: GENOMIC
required: sms:false

GENOMICSINGLECELL
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: GENOMIC SINGLE CELL
required: sms:false

METAGENOMIC
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: METAGENOMIC
required: sms:false

METATRANSCRIPTOMIC
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: METATRANSCRIPTOMIC
required: sms:false

SYNTHETIC
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: SYNTHETIC
required: sms:false

TRANSCRIPTOMIC
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: TRANSCRIPTOMIC
required: sms:false

TRANSCRIPTOMICSINGLECELL
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: TRANSCRIPTOMIC SINGLE CELL
required: sms:false

VIRALRNA
type: Class
comment: TBD
subclass of: CDSlibrarySource
is part of: schema.biothings.io
display name: VIRAL RNA
required: sms:false

5-methylcytidineantibody
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: 5-methylcytidine antibody
required: sms:false

CAGE
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: CAGE
required: sms:false

CDNA
type: Class
comment: Complementary DNA. A DNA copy of an mRNA or complex sample of mRNAs, made using reverse transcriptase
subclass of: Sequencing
subclass of: SpatialRead1
subclass of: SpatialRead2
subclass of: ScmCseqRead1
subclass of: ScmCseqRead2
subclass of: ScmCseqRead3
subclass of: Read1
subclass of: Read2
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: cDNA
required: sms:false
requires dependency: CDNAOffset
requires dependency: CDNALength

CDNAOligoDT
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: cDNA_oligo_dT
required: sms:false

CDNARandomPriming
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: cDNA_randomPriming
required: sms:false

CF-H
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: CF-H
required: sms:false

CF-M
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: CF-M
required: sms:false

CF-S
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: CF-S
required: sms:false

CF-T
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: CF-T
required: sms:false

ChIP
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: ChIP
required: sms:false

DNAse
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: DNAse
required: sms:false

HMPR
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: HMPR
required: sms:false

HybridSelection
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Hybrid Selection
required: sms:false

InverserRNA
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Inverse rRNA
required: sms:false

MBD2proteinmethyl-CpGbindingdomain
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: MBD2 protein methyl-CpG binding domain
required: sms:false

MDA
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: MDA
required: sms:false

MF
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: MF
required: sms:false

MNase
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: MNase
required: sms:false

MSLL
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: MSLL
required: sms:false

Oligo-dT
type: Class
comment: TBD
subclass of: ReverseTranscriptionPrimer
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Oligo-dT
required: sms:false

Other
type: Class
comment: TBD
subclass of: StripeCalling
subclass of: LoopCalling
subclass of: HistologyAssessmentBy
subclass of: HistologyAssessmentMedium
subclass of: AlcoholType
subclass of: ColorectalCancerTumorBorderConfiguration
subclass of: BreastCancerGenomicTestPerformed
subclass of: DataCollectionMode
subclass of: MSScanMode
subclass of: Immersion
subclass of: TypeofTobaccoUsed
subclass of: PrecancerousConditionType
subclass of: COVID19ComplicationsSeverity
subclass of: ClassificationofTumor
subclass of: BreastCarcinomaDetectionMethodType
subclass of: PriorInvasiveBreastDisease
subclass of: BreastCarcinomaSurgicalProcedureName
subclass of: OvarianCancerSurgicalOutcome
subclass of: ReadIndicator
subclass of: ExpressionUnits
subclass of: SlideChargeType
subclass of: FiducialMarker
subclass of: ReasonTreatmentEnded
subclass of: LabTestsforMMRStatus
subclass of: BreastCarcinomaHistologyCategory
subclass of: GliomaSpecificMetastasisSites
subclass of: AdditonalFindingsUninvolvedProstate
subclass of: Race
subclass of: SlicingMethod
subclass of: ImmunosuppressiveTreatmentType
subclass of: LungCancerDetectionMethodType
subclass of: ColorectalCancerDetectionMethodType
subclass of: BreastBiopsyProcedureFindingType
subclass of: BreastCancerAssessmentTests
subclass of: ProstateCancerCytologicMorphologicSubtypes
subclass of: SarcomaTumorExtensionType
subclass of: PancreaticIPMNPathologyEpithelialSubtype
subclass of: Pre-processingCompleted
subclass of: Pre-processingRequired
subclass of: MSSource
subclass of: DataCategory
subclass of: ExtentofTumorResection
subclass of: ColorectalPolypType
subclass of: BreastCarcinomaERStainingIntensity
subclass of: BreastCarcinomaPRStainingIntensity
subclass of: SarcomaSubtype
subclass of: LibrarySelectionMethod
subclass of: CutaneousMelanomaAdditionalFindings
subclass of: DiabetesTreatmentType
subclass of: OvarianCancerHistologicSubtype
subclass of: InvasiveDuctalBreastCarcinomaHistologicCategory
subclass of: ProstateCarcinomaHistologicType
subclass of: ScRNAseqWorkflowType
subclass of: MolecularAnalysisMethod
subclass of: SingleCellBarcodeMethodApplied
subclass of: LungAdjacentHistologyType
subclass of: VariantType
subclass of: LungCancerParticipantProcedureHistory
subclass of: MethodofDiagnosis
subclass of: FixativeType
subclass of: CDSlibrarySelection
subclass of: HPVPositiveType
subclass of: ConcomitantMedicationReceivedType
subclass of: TreatmentType
subclass of: CurrentLungCancerSymptoms
subclass of: SequencingPlatform
subclass of: MutationalSignatures
subclass of: LungCancerHarboringGenomicAberrations
subclass of: RelationshipType
subclass of: LungTopography
subclass of: Comorbidity
subclass of: PriorSitesofRadiation
subclass of: License
is part of: schema.biothings.io
display name: Other
required: sms:false

Padlockprobescapturemethod
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Padlock probes capture method
required: sms:false

PCR
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: PCR
required: sms:false

PolyA
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: PolyA
required: sms:false

RACE
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: RACE
required: sms:false

RANDOM
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: RANDOM
required: sms:false

RANDOMPCR
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: RANDOM PCR
required: sms:false

ReducedRepresentation
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Reduced Representation
required: sms:false

Repeatfractionation
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: repeat fractionation
required: sms:false

RestrictionDigest
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Restriction Digest
required: sms:false

RT-PCR
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: RT-PCR
required: sms:false

Sizefractionation
type: Class
comment: TBD
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: size fractionation
required: sms:false

Unspecified
type: Class
comment: TBD
subclass of: Gender
subclass of: RelationshipGender
subclass of: TumorExtranodalExtensionIndicator
subclass of: CDSlibrarySelection
is part of: schema.biothings.io
display name: Unspecified
required: sms:false

Paired-end
type: Class
comment: TBD
subclass of: CDSlibraryLayout
is part of: schema.biothings.io
display name: Paired-end
required: sms:false

Single-end
type: Class
comment: TBD
subclass of: CDSlibraryLayout
is part of: schema.biothings.io
display name: Single-end
required: sms:false

LS454
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: LS454
required: sms:false

ABISOLID
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: ABI_SOLID
required: sms:false

BGISEQ
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: BGISEQ
required: sms:false

CAPILLARY
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: CAPILLARY
required: sms:false

COMPLETEGENOMICS
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: COMPLETE_GENOMICS
required: sms:false

HELICOS
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: HELICOS
required: sms:false

ILLUMINA
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: ILLUMINA
required: sms:false

IONTORRENT
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: ION_TORRENT
required: sms:false

OXFORDNANOPORE
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: OXFORD_NANOPORE
required: sms:false

PACBIOSMRT
type: Class
comment: TBD
subclass of: CDSplatform
is part of: schema.biothings.io
display name: PACBIO_SMRT
required: sms:false

454GS
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: 454 GS
required: sms:false

454GS20
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: 454 GS 20
required: sms:false

454GSFLX
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: 454 GS FLX
required: sms:false

454GSFLX+
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: 454 GS FLX+
required: sms:false

454GSFLXTitanium
type: Class
comment: TBD
subclass of: CDSinstrumentModel
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: 454 GS FLX Titanium
required: sms:false

454GSJunior
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: 454 GS Junior
required: sms:false

HiSeqXFive
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: HiSeq X Five
required: sms:false

HiSeqXTen
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: HiSeq X Ten
required: sms:false

IlluminaGenomeAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina Genome Analyzer
required: sms:false

IlluminaGenomeAnalyzerII
type: Class
comment: TBD
subclass of: CDSinstrumentModel
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina Genome Analyzer II
required: sms:false

IlluminaGenomeAnalyzerIIx
type: Class
comment: TBD
subclass of: CDSinstrumentModel
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina Genome Analyzer IIx
required: sms:false

IlluminaHiScanSQ
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina HiScanSQ
required: sms:false

IlluminaHiSeq1000
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina HiSeq 1000
required: sms:false

IlluminaHiSeq1500
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina HiSeq 1500
required: sms:false

IlluminaHiSeq2000
type: Class
comment: TBD
subclass of: CDSinstrumentModel
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina HiSeq 2000
required: sms:false

IlluminaHiSeq2500
type: Class
comment: TBD
subclass of: CDSinstrumentModel
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina HiSeq 2500
required: sms:false

IlluminaHiSeq3000
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina HiSeq 3000
required: sms:false

IlluminaHiSeq4000
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina HiSeq 4000
required: sms:false

IlluminaiSeq100
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina iSeq 100
required: sms:false

IlluminaNovaSeq6000
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina NovaSeq 6000
required: sms:false

IlluminaMiniSeq
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina MiniSeq
required: sms:false

IlluminaMiSeq
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Illumina MiSeq
required: sms:false

NextSeq500
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: NextSeq 500
required: sms:false

NextSeq550
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: NextSeq 550
required: sms:false

HelicosHeliScope
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Helicos HeliScope
required: sms:false

AB5500GeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 5500 Genetic Analyzer
required: sms:false

AB5500xlGeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 5500xl Genetic Analyzer
required: sms:false

AB5500x-WlGeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 5500x-Wl Genetic Analyzer
required: sms:false

ABSOLiD3PlusSystem
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD 3 Plus System
required: sms:false

ABSOLiD4System
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD 4 System
required: sms:false

ABSOLiD4hqSystem
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD 4hq System
required: sms:false

ABSOLiDPISystem
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD PI System
required: sms:false

ABSOLiDSystem
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD System
required: sms:false

ABSOLiDSystem2.0
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD System 2.0
required: sms:false

ABSOLiDSystem3.0
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB SOLiD System 3.0
required: sms:false

CompleteGenomics
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Complete Genomics
required: sms:false

PacBioRS
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: PacBio RS
required: sms:false

PacBioRSII
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: PacBio RS II
required: sms:false

PacBioSequel
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: PacBio Sequel
required: sms:false

PacBioSequelII
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: PacBio Sequel II
required: sms:false

IonTorrentPGM
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Ion Torrent PGM
required: sms:false

IonTorrentProton
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Ion Torrent Proton
required: sms:false

IonTorrentS5XL
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Ion Torrent S5 XL
required: sms:false

IonTorrentS5
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: Ion Torrent S5
required: sms:false

AB310GeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 310 Genetic Analyzer
required: sms:false

AB3130GeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3130 Genetic Analyzer
required: sms:false

AB3130xLGeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3130xL Genetic Analyzer
required: sms:false

AB3500GeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3500 Genetic Analyzer
required: sms:false

AB3500xLGeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3500xL Genetic Analyzer
required: sms:false

AB3730GeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3730 Genetic Analyzer
required: sms:false

AB3730xLGeneticAnalyzer
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: AB 3730xL Genetic Analyzer
required: sms:false

GridION
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: GridION
required: sms:false

MinION
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: MinION
required: sms:false

PromethION
type: Class
comment: TBD
subclass of: SequencingPlatform
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: PromethION
required: sms:false

BGISEQ-500
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: BGISEQ-500
required: sms:false

DNBSEQ-G400
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: DNBSEQ-G400
required: sms:false

DNBSEQ-T7
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: DNBSEQ-T7
required: sms:false

DNBSEQ-G50
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: DNBSEQ-G50
required: sms:false

MGISEQ-2000RS
type: Class
comment: TBD
subclass of: CDSinstrumentModel
is part of: schema.biothings.io
display name: MGISEQ-2000RS
required: sms:false

Checksum
type: Class
comment: MD5 checksum of the BAM file
subclass of: InformationContentEntity
is part of: schema.biothings.io
display name: Checksum
required: sms:true

HTANBiospecimenID
type: Class
comment: HTAN ID associated with a biosample based on HTAN ID SOP (eg HTANx_yyy_zzz)
subclass of: Biospecimen
is part of: schema.biothings.io
display name: HTAN Biospecimen ID
required: sms:true
validation rules: regex match ^(HTA([1-9]|1[0-6]))_((EXT)?([0-9]\d*|0000))_([0-9]\d*|0000)$ warning

Biospecimen
type: Class
comment: HTAN biological entity; this can be tissue, blood, analyte and subsamples of those
subclass of: Biosample
is part of: schema.biothings.io
display name: Biospecimen
required: sms:false
requires component: Patient
requires dependency: Component
requires dependency: HTANBiospecimenID
requires dependency: SourceHTANBiospecimenID
requires dependency: HTANParentID
requires dependency: TimepointLabel
requires dependency: CollectionDaysfromIndex
requires dependency: AdjacentBiospecimenIDs
requires dependency: BiospecimenType
requires dependency: AcquisitionMethodType
requires dependency: FixativeType
requires dependency: StorageMethod
requires dependency: ProcessingDaysfromIndex
requires dependency: ProtocolLink
requires dependency: SiteDataSource
requires dependency: CollectionMedia
requires dependency: MountingMedium
requires dependency: ProcessingLocation
requires dependency: HistologyAssessmentBy
requires dependency: HistologyAssessmentMedium
requires dependency: PreinvasiveMorphology
requires dependency: TumorInfiltratingLymphocytes
requires dependency: DegreeofDysplasia
requires dependency: DysplasiaFraction
requires dependency: NumberProliferatingCells
requires dependency: PercentEosinophilInfiltration
requires dependency: PercentGranulocyteInfiltration
requires dependency: PercentInflamInfiltration
requires dependency: PercentLymphocyteInfiltration
requires dependency: PercentMonocyteInfiltration
requires dependency: PercentNecrosis
requires dependency: PercentNeutrophilInfiltration
requires dependency: PercentNormalCells
requires dependency: PercentStromalCells
requires dependency: PercentTumorCells
requires dependency: PercentTumorNuclei
requires dependency: FiducialMarker
requires dependency: SlicingMethod
requires dependency: LysisBuffer
requires dependency: MethodofNucleicAcidIsolation

HTANParentID
type: Class
comment: HTAN ID of parent from which the biospecimen was obtained. Parent could be another biospecimen or a research participant.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: HTAN Parent ID
required: sms:true

HTANParentDataFileID
type: Class
comment: HTAN Data File Identifier indicating the file(s) from which these files were derived
subclass of: File
is part of: schema.biothings.io
display name: HTAN Parent Data File ID
required: sms:true

ClinicalDataTier2
type: Class
comment: Tier 2 Cancer Data
subclass of: Patient
is part of: schema.biothings.io
display name: Clinical Data Tier 2
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: SentinelLymphNodeCount
requires dependency: SentinelNodePositiveAssessmentCount
requires dependency: TumorExtranodalExtensionIndicator
requires dependency: SatelliteMetastasisPresentIndicator
requires dependency: OtherBiopsyResectionSite
requires dependency: ExtentofTumorResection
requires dependency: PriorSitesofRadiation
requires dependency: Immunosuppression
requires dependency: ConcomitantMedicationReceivedType
requires dependency: FamilyMemberVitalStatusIndicator
requires dependency: COVID19OccurrenceIndicator
requires dependency: COVID19CurrentStatus
requires dependency: COVID19PositiveLabTestIndicator
requires dependency: COVID19AntibodyTesting
requires dependency: COVID19ComplicationsSeverity
requires dependency: COVID19CancerTreatmentFollowup
requires dependency: Ecigvapeuse
requires dependency: Ecigvape30dayusenum
requires dependency: Ecigvapetimesperday
requires dependency: Typeofsmokeexposurecumulativeyears
requires dependency: Chewingtobaccodailyusecount
requires dependency: Secondhandsmokeexposureyears
requires dependency: KnownGeneticPredispositionMutation
requires dependency: HereditaryCancerPredispositionSyndrome
requires dependency: CancerAssociatedGeneMutations
requires dependency: MutationalSignatures
requires dependency: MismatchRepairSystemStatus
requires dependency: LabTestsforMMRStatus
requires dependency: ModeofCancerDetection
requires dependency: EducationLevel
requires dependency: CountryofBirth
requires dependency: MedicallyUnderservedArea
requires dependency: RuralvsUrban
requires dependency: CancerIncidence
requires dependency: CancerIncidenceLocation

TimepointLabel
type: Class
comment: Label to identify the time point at which the clinical data or biospecimen was obtained (e.g. Baseline, End of Treatment, Overall survival, Final). NO PHI/PII INFORMATION IS ALLOWED.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Timepoint Label
required: sms:true

StartDaysfromIndex
type: Class
comment: Number of days from the date of birth (index date) to the date of an event (e.g. exposure to environmental factor, treatment start, etc.). If not applicable please enter 'Not Applicable'
subclass of: Patient
is part of: schema.biothings.io
display name: Start Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

StopDaysfromIndex
type: Class
comment: Number of days from the date of birth (index date) to the end date of the event (e.g. exposure to environmental factor, treatment start, etc.). Note: if the event occurs at a single time point, e.g. a diagnosis or a lab test, the values for this column is 'Not Applicable'
subclass of: Patient
is part of: schema.biothings.io
display name: Stop Days from Index
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

SentinelLymphNodeCount
type: Class
comment: Numeric count of sentinel lymph nodes.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Sentinel Lymph Node Count
required: sms:false

SentinelNodePositiveAssessmentCount
type: Class
comment: The number or amount of metastatic neoplasms related to the confirmed presence of disease or specific microorganisms during examination of the first rounded mass of lymphatic tissue to which cancer is likely to spread from the primary tumor.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Sentinel Node Positive Assessment Count
required: sms:false

TumorExtranodalExtensionIndicator
type: Class
comment: The indicator to determine extranodal involvement or extent of the disease.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Absent
range includes: Indeterminate
range includes: NO
range includes: YES
range includes: Nosourcedocumentation
range includes: Notapplicable
range includes: Notsampledordissected
range includes: Present
range includes: Present-extensive
range includes: Present-minimal
range includes: UNKNOWN
range includes: Unspecified
display name: Tumor Extranodal Extension Indicator
required: sms:false

SatelliteMetastasisPresentIndicator
type: Class
comment: A yes/no indicator to ask if intransit metastases or satellite lesions are present.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
display name: Satellite Metastasis Present Indicator
required: sms:false

OtherBiopsyResectionSite
type: Class
comment: A description of the location on or within the human body where the surgical biopsy/resection procedure was performed (Not covered under HTAN Clinical Data Tier 1)
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Other Biopsy Resection Site
required: sms:false

ExtentofTumorResection
type: Class
comment: The degree to which the lesion has been cut out, or resected.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: GrossTotalResection
range includes: OpenBiopsy
range includes: SubtotalResection
range includes: ExtensiveSubtotal
range includes: Minor
range includes: Optimaldebulking
range includes: Other
range includes: Partialdebulking
range includes: Segmental
range includes: Suboptimal
range includes: Suboptimaldebulking
range includes: NTR
range includes: Unknown
range includes: NotReported
range includes: NotApplicable
display name: Extent of Tumor Resection
required: sms:false

PriorSitesofRadiation
type: Class
comment: The anatomic location to which radiation treatment was administered to a patient prior to enrollment on a protocol.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Abdomentotal
range includes: AbdominalWall
range includes: Acetabulum
range includes: Adenoid
range includes: Adipose
range includes: Adrenal
range includes: AlveolarRidge
range includes: AmnioticFluid
range includes: AmpullaofVater
range includes: AnalSphincter
range includes: Ankle
range includes: Anorectum
range includes: AntecubitalFossa
range includes: Antrum
range includes: Anus
range includes: Aorta
range includes: AorticBody
range includes: Appendix
range includes: AqueousFluid
range includes: Arm
range includes: Artery
range includes: AscendingColon
range includes: AscendingColonHepaticFlexure
range includes: Ascites
range includes: AuditoryCanal
range includes: AutonomicNervousSystem
range includes: Axilla
range includes: Back
range includes: BileDuct
range includes: Bladder
range includes: Blood
range includes: BloodVessel
range includes: Bodytotal
range includes: Bone
range includes: BoneMarrow
range includes: Bonenon-spine
range includes: Bowel
range includes: Brain
range includes: BrainStem
range includes: Breast
range includes: BroadLigament
range includes: Bronchiole
range includes: Bronchus
range includes: Brow
range includes: BuccalCavity
range includes: BuccalMucosa
range includes: Buttock
range includes: Calf
range includes: Capillary
range includes: Cardia
range includes: Carina
range includes: CarotidArtery
range includes: CarotidBody
range includes: Cartilage
range includes: Cecum
range includes: Cell-Line
range includes: CentralNervousSystem
range includes: Cerebellum
range includes: CerebralCortex
range includes: CerebrospinalFluid
range includes: Cerebrum
range includes: CervicalSpine
range includes: Cervix
range includes: Chest
range includes: ChestWall
range includes: Chin
range includes: Clavicle
range includes: Clitoris
range includes: Colon
range includes: ColonMucosaOnly
range includes: CommonDuct
range includes: Conjunctiva
range includes: ConnectiveTissue
range includes: Dermal
range includes: DescendingColon

Immunosuppression
type: Class
comment: The indicator that describes whether or not immunosuppressive therapy was administered.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
range includes: NotDone
display name: Immunosuppression
required: sms:false

ConcomitantMedicationReceivedType
type: Class
comment: An enumerated list of the type of concomitant medication received by the patient.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Anticoagulantagents
range includes: Anticonvulsant
range includes: Antifungal
range includes: Antiplateletagents
range includes: Antidepressants-StrongCYP2D6inhibitors
range includes: Anxiolyticsorsedatives
range includes: Aspirin
range includes: Bisphosphonatesfortreatment/preventionofboneloss
range includes: Corticosteroid
range includes: COX-2inhibitor
range includes: Decadron
range includes: Diabetes-Insulin
range includes: Diabetes-Metformincontainingagents
range includes: Growthfactor
range includes: Intravaginalestrogenpreparations
range includes: Lipid-loweringdrugs
range includes: Non-prescriptionsupplementsformemory
range includes: Non-prescriptionsupplementsforreliefofhotflashes
range includes: Non-steroidalanti-inflammatoryagents
range includes: Opioids
range includes: Other
range includes: Prescriptionmedicationsformemory
range includes: Prescriptionmedicationsforreliefofhotflashes
range includes: Prophylacticantiplatelettherapy
range includes: Tricyclicantidepressants
range includes: NotApplicable
range includes: Unknown
range includes: NotReported
display name: Concomitant Medication Received Type
required: sms:false

FamilyMemberVitalStatusIndicator
type: Class
comment: The response indicates whether the family member of the patient with a history of cancer is alive. (Extension to GDC attributes in Family History Tier 1)
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: VitalStatusAlive
range includes: VitalStatusDead
range includes: Unknown
range includes: NotReported
display name: Family Member Vital Status Indicator
required: sms:false

COVID19OccurrenceIndicator
type: Class
comment: The indicator that describes whether or not a COVID-19 infectious disorder occurred.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
range includes: NotDone
display name: COVID19 Occurrence Indicator
required: sms:false

COVID19CurrentStatus
type: Class
comment: The patient's current COVID-19 status of sign or symptom events or interventions
subclass of: Exposure
is part of: schema.biothings.io
range includes: Patientcurrentlyhassymptoms
range includes: Patienthadsymptomsbutnowisfullyrecovered
range includes: PatientneverhadanysymptomsofCOVID-19
range includes: StatusunknownduetogeneralCOVID-19relatedtravelrestrictions
range includes: Statusunknownduetolackofdisease/tumorassessmentduetoCOVID-19diagnosis
range includes: Statusunknownduetootherreasons
display name: COVID19 Current Status
required: sms:false

COVID19PositiveLabTestIndicator
type: Class
comment: The indicator that describes whether or not there was a COVID-19 positive test result.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
range includes: NotDone
display name: COVID19 Positive Lab Test Indicator
required: sms:false

COVID19AntibodyTesting
type: Class
comment: Text term that demonstrates the test results of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies to the SARS-CoV-2 virus in subject serum samples.
subclass of: Exposure
is part of: schema.biothings.io
range includes: SARS-CoV-2IgMantibodypositive
range includes: SARS-CoV-2IgGantibodypositive
range includes: SARS-CoV-2IgG/IgMantibodypositive
range includes: SARS-CoV-2IgMantibodynegative
range includes: SARS-CoV-2IgGantibodynegative
range includes: SARS-CoV-2IgG/IgMantibodynegative
range includes: Unknown
range includes: NotApplicable
range includes: NotDone
display name: COVID19 Antibody Testing
required: sms:false

COVID19ComplicationsSeverity
type: Class
comment: Text term that retrospectively indicates the worst complications during COVID-19 infectious disorder in the patient.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Cardiaccomplications
range includes: Pulmonarycomplications
range includes: Systemiccomplications
range includes: Other
range includes: NotApplicable
range includes: Unknown
display name: COVID19 Complications Severity
required: sms:false

COVID19CancerTreatmentFollowup
type: Class
comment: Indicator that describes if cancer treatment was modified for the patient due to COVID-19 infectious disorder
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: COVID19 Cancer Treatment Followup
required: sms:false

Ecigvapeuse
type: Class
comment: Use of non-traditional cigarette nicotine delivery device (electronic cigarette, ENDS - electronic nicotine delivery system)
subclass of: Exposure
is part of: schema.biothings.io
range includes: Current
range includes: Former
range includes: Never
range includes: Unknown
display name: Ecig vape use
required: sms:false

Ecigvape30dayusenum
type: Class
comment: Number of days e-cigarettes or vaping device was used in the last 30 days
subclass of: Exposure
is part of: schema.biothings.io
display name: Ecig vape 30 day use num
required: sms:false

Ecigvapetimesperday
type: Class
comment: e-cig frequency of use (times per day—one “time” consists of around 15 puffs or lasts around 10 minutes)
subclass of: Exposure
is part of: schema.biothings.io
display name: Ecig vape times per day
required: sms:false

Typeofsmokeexposurecumulativeyears
type: Class
comment: The number of cumulative years of the patient's specific type of smoke exposure
subclass of: Exposure
is part of: schema.biothings.io
display name: Type of smoke exposure cumulative years
required: sms:false

Chewingtobaccodailyusecount
type: Class
comment: The quantity of daily use of tobacco, in the form of a plug, usually flavored, for chewing rather than smoking.
subclass of: Exposure
is part of: schema.biothings.io
display name: Chewing tobacco daily use count
required: sms:false

Secondhandsmokeexposureyears
type: Class
comment: The number of cumulative years of the patient's exposure to second-hand cigarette smoke
subclass of: Exposure
is part of: schema.biothings.io
display name: Second hand smoke exposure years
required: sms:false

KnownGeneticPredispositionMutation
type: Class
comment: A yes/no/unknown indicator to identify whether there is a known genetic predisposition mutation present in the patient.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
display name: Known Genetic Predisposition Mutation
required: sms:false

HereditaryCancerPredispositionSyndrome
type: Class
comment: History of presence of inherited genetic predisposition syndrome that confers heightened susceptibility to cancer in the patient.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: Alpha-1antitrypsin
range includes: Attenuatedfamilialadenomatouspolyposis
range includes: BAP1mutantdisease
range includes: Beckwith-Wiedemann
range includes: Biliarydisorder
range includes: Birt-Hogg-Dubesyndrome
range includes: Carneycomplex
range includes: Cirrhosisunknownetiology
range includes: Constitutionalmismatchrepairdeficiency
range includes: Familialadenomatouspolyposis
range includes: Familialgastrointestinalstromaltumor
range includes: Familialpancreaticcancer
range includes: Familialprostatecancer
range includes: Familialrenalcancer
range includes: Fanconianemia
range includes: GlycogenStorageDisease
range includes: Gorlinsyndrome
range includes: Hereditarybreast–ovariancancersyndrome
range includes: Hereditarydiffusegastriccancer
range includes: Hereditaryleiomyoma-renalcellcarcinoma
range includes: Hereditarymelanoma
range includes: Hereditarymixedpolyposissyndrome
range includes: HereditarypapillaryRCC
range includes: Hereditarypapillaryrenalcellcarcinoma
range includes: Hereditaryparaganglioma–pheochromocytomasyndrome
range includes: Hereditaryrenaloncocytoma
range includes: Hereditaryretinoblastoma
range includes: Juvenilepolyposissyndrome
range includes: Li-Fraumenisyndrome
range includes: Lynchsyndrome
range includes: Melanoma–astrocytomasyndrome
range includes: MultipleendocrineneoplasiatypeI
range includes: MultipleendocrineneoplasiatypeII
range includes: MUTYH-associatedpolyposis
range includes: Nevoidbasalcellcarcinomasyndrome
range includes: NotApplicable
range includes: NotReported
range includes: Peutz–Jegherssyndrome
range includes: Cowdensyndrome
range includes: RhabdoidtumorpredispositionsyndrometypeI
range includes: RhabdoidtumorpredispositionsyndrometypeII
range includes: Rubinstein-Taybisyndrome
range includes: SDHassociatedrenalcancer
range includes: Serratedpolyposissyndrome
range includes: Tuberoussclerosiscomplex
range includes: Turcotsyndrome
range includes: Tyrosinemia
range includes: Unknown
range includes: VonHippel-LindauSyndrome
display name: Hereditary Cancer Predisposition Syndrome
required: sms:false

CancerAssociatedGeneMutations
type: Class
comment: Type of inherited germline or other gene mutations that confers heightened susceptibility to cancer identified in patient history
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: APCmutation
range includes: ALKmutation
range includes: ARFmutation
range includes: ATMmutation
range includes: ATRXmutation
range includes: ACVR1mutation
range includes: BAP1mutation
range includes: BMPR1Amutation
range includes: BLMmutation
range includes: BRCA1mutation
range includes: BRCA1and2mutation
range includes: BRCA2mutation
range includes: BRAFmutation
range includes: CDH1mutation
range includes: CDKN2Amutation
range includes: CDKN2Aandp14ARFmutation
range includes: CHKmutation
range includes: ETV6mutation
range includes: EGFRmutation
range includes: FHmutation
range includes: FLCNmutation
range includes: GREM1mutation
range includes: HOXB13mutation
range includes: H3K27Mmutation
range includes: H3G34R/Vmutation
range includes: IKZF1mutation
range includes: KITmutation
range includes: KRASmutation
range includes: MAXmutation
range includes: MEN1mutation
range includes: METmutation
range includes: MLH1mutation
range includes: MSH2mutation
range includes: MSH6mutation
range includes: MUTYHmutation
range includes: NF1mutation
range includes: NF2mutation
range includes: NotApplicable
range includes: NotReported
range includes: P14ARFmutation
range includes: PALB2mutation
range includes: PAX5mutation
range includes: PDGFRAmutation
range includes: PHOX2Bmutation
range includes: PMS2mutation
range includes: PolDmutation
range includes: PolEmutation
range includes: POT1mutation
range includes: PRKAR1Amutation
range includes: PTCHmutation
range includes: PTENmutation
range includes: ROS1mutation
range includes: RB1mutation
range includes: RETmutation
range includes: SDHAF2mutation
range includes: SDHBmutation
range includes: SDHCmutation
range includes: SDHDmutation
range includes: SETD2mutation
range includes: SMAD4mutation
range includes: SMARCA4mutation
range includes: SMARCB1mutation
range includes: STK11mutation
range includes: TMEM127mutation
range includes: TP53mutation
range includes: TSC1mutation
range includes: TSC2mutation
range includes: Unknown
range includes: VHLmutation
display name: Cancer Associated Gene Mutations
required: sms:false

MutationalSignatures
type: Class
comment: Mutational signatures identified in the patient, includes signatures linked to selected exogenous carcinogens, endogenous and enzymatic modification of DNA or defective DNA repair. Note: Include only outputs of tests that were completed clinically for the participant and only include data from a diagnostic array that was completed prior to research sequencing was done.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: UVlightinducedmutations
range includes: Tobaccouseassociatedmutations
range includes: Ageofcancerdiagnosis
range includes: Transcriptionalstrandbias
range includes: APOBECenzymesassociatedmutations
range includes: Alteredactivityoftheerror-pronepolymerasePOLε(POLE)
range includes: DNAMMRDeficiency
range includes: Iggenehypermutation
range includes: Signature1A
range includes: Signature1B
range includes: Signature2
range includes: Signature3
range includes: Signature4
range includes: Signature5
range includes: Signature6
range includes: Signature7
range includes: Signature8
range includes: Signature9
range includes: Signature10
range includes: Signature11
range includes: Signature12
range includes: Signature13
range includes: Signature14
range includes: Signature15
range includes: Signature16
range includes: Signature17
range includes: Signature18
range includes: Signature19
range includes: Signature20
range includes: Signature21
range includes: Other
range includes: Datanotavailable
range includes: NotApplicable
range includes: NotReported
range includes: Unknown
display name: Mutational Signatures
required: sms:false

MismatchRepairSystemStatus
type: Class
comment: The text that best describes the condition or state of MMR (mismatch repair system) in the patient
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: MismatchrepairdeficiencyMMRD
range includes: MismatchrepairproficiencyMMPP
range includes: MicrosatelliteinstabilityhighMSIH
range includes: MicrosatellitestableMSS
range includes: Unknownorother
display name: Mismatch Repair System Status
required: sms:false

LabTestsforMMRStatus
type: Class
comment: Laboratory tests used to evaluate the status of mismatch repair pathways
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: IHCstainingformismatchrepairproteins
range includes: PCRtoevaluatemicrosatelliteinstability
range includes: MLH1 promotermethylationanalysis
range includes: BRAF sequencing
range includes: Other
range includes: NotApplicable
range includes: Unknown
display name: Lab Tests for MMR Status
required: sms:false

ModeofCancerDetection
type: Class
comment: Text term used to describe the mode of cancer detection, like standard of care screening or random detection
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: StandardofCareScreening
range includes: ClinicalExaminationofunrelatedcancersymptoms
range includes: Incidentaloma
range includes: IntervalCancer
range includes: Datanotavailable
display name: Mode of Cancer Detection
required: sms:false

EducationLevel
type: Class
comment: Highest level of education that the patient completed (direct patient-derived information)
subclass of: ClinicalTier2
is part of: schema.biothings.io
range includes: Bachelor'sdegree
range includes: Doctoraldegreeorprofessionaldegree
range includes: Gradeschool
range includes: Graduateorprofessionaldegree
range includes: Master'sdegree
range includes: Noformaleducation
range includes: Nothighschoolgraduate
range includes: Somecollegeorassociatedegree
range includes: Datanotavailable
display name: Education Level
required: sms:false

CountryofBirth
type: Class
comment: Country where the patient was born.
subclass of: ClinicalTier2
is part of: schema.biothings.io
range includes: Afghanistan
range includes: Albania
range includes: Algeria
range includes: Andorra
range includes: Angola
range includes: Anguilla
range includes: AntiguaandBarbuda
range includes: Argentina
range includes: Armenia
range includes: Aruba
range includes: Australia
range includes: Austria
range includes: Azerbaijan
range includes: Bahamas
range includes: Bahrain
range includes: Bangladesh
range includes: Barbados
range includes: Belarus
range includes: Belgium
range includes: Belize
range includes: Benin
range includes: Bermuda
range includes: Bhutan
range includes: Bolivia
range includes: BosniaandHerzegovina
range includes: Botswana
range includes: Brazil
range includes: Brunei
range includes: Bulgaria
range includes: BurkinaFaso
range includes: Burundi
range includes: Cambodia
range includes: Cameroon
range includes: Canada
range includes: CapeVerde
range includes: CaymanIslands
range includes: CentralAfricanRepublic
range includes: Chad
range includes: Chile
range includes: China
range includes: Colombia
range includes: Comoros
range includes: Congo
range includes: CookIslands
range includes: CostaRica
range includes: Coted'Ivoire
range includes: Croatia
range includes: Cuba
range includes: Curacao
range includes: Cyprus
range includes: CzechRepublic(Czechia)
range includes: DemocraticRepublicoftheCongo
range includes: Denmark
range includes: Djibouti
range includes: Dominica
range includes: DominicanRepublic
range includes: Ecuador
range includes: Egypt
range includes: ElSalvador
range includes: EquatorialGuinea
range includes: Eritrea
range includes: Estonia
range includes: Eswatini
range includes: Ethiopia
range includes: FalklandIslands(Malvinas)
range includes: FaroeIslands
range includes: FederatedStatesofMicronesia
range includes: Fiji
range includes: Finland
range includes: France
range includes: FrenchGuiana
range includes: FrenchPolynesia
range includes: Gabon
range includes: Gambia
range includes: Georgia

MedicallyUnderservedArea
type: Class
comment: Areas or populations designated by HRSA as having too few primary care providers, high infant mortality, high poverty or a high elderly population: Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/ - enter the zip code in the main text field and use the associated county on the right side of the result field. Go to data.hrsa.gov website and select "Query Data". Pick the Medically Underserved Areas/Populations (MUA/P) data source in the step 1 menu and select "View Data". Enter the name of the county (_______ county) in the first "Service Area" column, adding the state in the 5th column may help direct you to the data. If the designation type in the third column is "medically underserved area" enter "Yes" as the value. If the county generates a "No data available in table" enter "No" as the value. A value of "Unknown" indicates that sufficient data was not available to look up the value. If value is yes, complete the Medically_underserved_score data element.
subclass of: ClinicalTier2
is part of: schema.biothings.io
range includes: MedicallyUnderservedArea-Yes
range includes: MedicallyUnderservedArea-No
range includes: MedicallyUnderservedArea-Unknown
display name: Medically Underserved Area
required: sms:false

RuralvsUrban
type: Class
comment: Density of population in the county of residence, based on census data (updated last on 4/28/20). Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the associated county on the right side of the result field. Go to https://www2.census.gov/programs-surveys/acs/data/covid_19/Data_Profiles_for_HHS/050-County_By_State/. Select the dp02_XX.csv file where XX = the two letter abbreviation for the appropriate state. On row 166 find the total population for the appropriate county. If the total population is <2,500 enter a value of "Rural Population"; if 2,500 - 50,000 enter a value of "Urban Cluster"; or if >50,000 enter "Urban Population"
subclass of: ClinicalTier2
is part of: schema.biothings.io
range includes: UrbanPopulation(population>50000)
range includes: UrbanCluster(population2500-50000)
range includes: RuralPopulation(population<2500)
display name: Rural vs Urban
required: sms:false

CancerIncidence
type: Class
comment: Incidence of specific cancer type in a defined area (a number between 0 and 100). The rate of incident cases per population of 100,000 persons of a specific type of cancer as designated in the "primary_diagnosis" data element in the county where the patient resides, using the most recent 2013-2017 NCI Cancer Atlas derived data. Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the asociated county on the right side of the result field. On the https://gis.cancer.gov/canceratlas/tableview/ website, choose "Incidence" from the Topic dropdown menu, state of interest from the Area menu, "All Races" from the Race menu, and the cancer type ("Both Sexes" when possible) from the Statistic menu. Find the county of interest and enter the numeric Age-Adjusted Rate per 100,000 as the value.
subclass of: ClinicalTier2
is part of: schema.biothings.io
display name: Cancer Incidence
required: sms:false

CancerIncidenceLocation
type: Class
comment: The county and state in which the patient lives and to which the cancer_incidence data correlates. Record as "County, State" as they appear in the incidence box from which the cancer_incidence data is obtained in the https://gis.cancer.gov/canceratlas/tableview/ website
subclass of: ClinicalTier2
is part of: schema.biothings.io
display name: Cancer Incidence Location
required: sms:false

SRRSClinicalDataTier2
type: Class
comment: Cancer related clinical data specific to SRRS
subclass of: Patient
is part of: schema.biothings.io
display name: SRRS Clinical Data Tier 2
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: EducationLevel
requires dependency: CountryofBirth
requires dependency: MedicallyUnderservedArea
requires dependency: RuralvsUrban
requires dependency: CancerIncidence
requires dependency: CancerIncidenceLocation
requires dependency: Ethnicity
requires dependency: Gender
requires dependency: Race
requires dependency: VitalStatus
requires dependency: AgeatDiagnosis
requires dependency: DaystoLastFollowup
requires dependency: DaystoLastKnownDiseaseStatus
requires dependency: DaystoRecurrence
requires dependency: LastKnownDiseaseStatus
requires dependency: Morphology
requires dependency: PrimaryDiagnosis
requires dependency: ProgressionorRecurrence
requires dependency: SiteofResectionorBiopsy
requires dependency: TissueorOrganofOrigin
requires dependency: NCIAtlasCancerSite
requires dependency: TumorGrade
requires dependency: PackYearsSmoked
requires dependency: YearsSmoked
requires dependency: DaystoFollowUp
requires dependency: GeneSymbol
requires dependency: MolecularAnalysisMethod
requires dependency: TestResult
requires dependency: TreatmentType
requires dependency: TumorLargestDimensionDiameter

Ethnicity
type: Class
comment: An individual's self-described social and cultural grouping, specifically whether an individual describes themselves as Hispanic or Latino. The provided values are based on the categories defined by the U.S. Office of Management and Business and used by the U.S. Census Bureau.
subclass of: Demographics
is part of: schema.biothings.io
range includes: Hispanicorlatino
range includes: Nothispanicorlatino
range includes: Unknown
range includes: NotReported
range includes: Notallowedtocollect
display name: Ethnicity
required: sms:true

Gender
type: Class
comment: Text designations that identify gender. Gender is described as the assemblage of properties that distinguish people on the basis of their societal roles. [Identification of gender is based upon self-report and may come from a form, questionnaire, interview, etc.]
subclass of: Demographics
is part of: schema.biothings.io
range includes: Female
range includes: Male
range includes: Unknown
range includes: Unspecified
range includes: NotReported
display name: Gender
required: sms:true

Race
type: Class
comment: An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation withina a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.
subclass of: Demographics
is part of: schema.biothings.io
range includes: White
range includes: Americanindianoralaskanative
range includes: Blackorafricanamerican
range includes: Asian
range includes: Nativehawaiianorotherpacificislander
range includes: Other
range includes: Unknown
range includes: NotReported
range includes: Notallowedtocollect
display name: Race
required: sms:true

VitalStatus
type: Class
comment: The survival state of the person registered on the protocol.
subclass of: Demographics
is part of: schema.biothings.io
range includes: Alive
range includes: Dead
range includes: Unknown
range includes: NotReported
display name: Vital Status
required: sms:true

AgeatDiagnosis
type: Class
comment: Age at the time of diagnosis expressed in number of days since birth.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Age at Diagnosis
required: sms:true

DaystoLastFollowup
type: Class
comment: Time interval from the date of last follow up to the date of initial pathologic diagnosis, represented as a calculated number of days. If not applicable please enter 'Not Applicable'
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Days to Last Follow up
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

DaystoLastKnownDiseaseStatus
type: Class
comment: Time interval from the date of last follow up to the date of initial pathologic diagnosis, represented as a calculated number of days. If not applicable please enter 'Not Applicable'
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Days to Last Known Disease Status
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

DaystoRecurrence
type: Class
comment: Number of days between the date used for index and the date the patient's disease recurred. If not applicable please enter 'Not Applicable'
subclass of: FollowUp
is part of: schema.biothings.io
display name: Days to Recurrence
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

LastKnownDiseaseStatus
type: Class
comment: Text term that describes the last known state or condition of an individual's neoplasm.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Distantmetrecurrence/progression
range includes: Loco-regionalrecurrence/progression
range includes: Biochemicalevidenceofdiseasewithoutstructuralcorrelate
range includes: Tumorfree
range includes: Unknowntumorstatus
range includes: Withtumor
range includes: NotReported
range includes: NotAllowedToCollect
range includes: NotApplicable
display name: Last Known Disease Status
required: sms:true

Morphology
type: Class
comment: The third edition of the International Classification of Diseases for Oncology, published in 2000 used principally in tumor and cancer registries for coding the site (topography) and the histology (morphology) of neoplasms. The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs. In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains. A system of numbered categories for representation of data.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Morphology
required: sms:true

PrimaryDiagnosis
type: Class
comment: Text term used to describe the patient's histologic diagnosis, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Acinarcellcarcinoma
range includes: Acutebasophilicleukaemia
range includes: AcuteleukemiaBurkitttype
range includes: AcuteleukemiaNOS
range includes: Acutelymphaticleukemia
range includes: Acutelymphoblasticleukemia-lymphomaNOS
range includes: AcutelymphoblasticleukemiamatureB-celltype
range includes: AcutelymphoblasticleukemiaNOS
range includes: Acutelymphoblasticleukemiaprecursorcelltype
range includes: Acutelymphocyticleukemia
range includes: Acutelymphoidleukemia
range includes: Acutemyeloidleukemiaminimaldifferentiation
range includes: AcutemyeloidleukemiaMLL
range includes: AcutemyeloidleukemiaNOS
range includes: Acutemyelomonocyticleukemia
range includes: AcutepromyelocyticleukemiaNOS
range includes: Adenocarcinoidtumor
range includes: Adenocarcinomacombinedwithothertypesofcarcinoma
range includes: AdenocarcinomainapolypNOS
range includes: Adenocarcinomainadenomatouspolyp
range includes: Adenocarcinomainpolypoidadenoma
range includes: AdenocarcinomainsituinapolypNOS
range includes: Adenocarcinomainsituinadenomatouspolyp
range includes: Adenocarcinomainsituintubularadenoma
range includes: Adenocarcinomainsitumucinous
range includes: Adenocarcinomainsitunon-mucinous
range includes: AdenocarcinomainsituNOS
range includes: Adenocarcinomaintubularadenoma
range includes: Adenocarcinomainvillousadenoma
range includes: Adenocarcinomaofanalducts
range includes: Adenocarcinomaofanalglands
range includes: Adenocarcinomadiffusetype
range includes: Adenocarcinomaendocervicaltype
range includes: Adenocarcinomaintestinaltype
range includes: AdenocarcinomametastaticNOS
range includes: AdenocarcinomaNOS
range includes: Adenocarcinomapancreatobiliarytype
range includes: Adultrhabdomyoma
range includes: AdultT-celllymphoma
range includes: AdultT-celllymphoma/leukemia
range includes: Astrocytomaanaplastic
range includes: Astrocytomalowgrade
range includes: AstrocytomaNOS
range includes: BcelllymphomaNOS
range includes: Blymphoblasticleukemia/lymphomawithhyperdiploidy
range includes: Blymphoblasticleukemia/lymphomaNOS
range includes: B-ALL
range includes: B-celllymphocyticleukemia/smalllymphocyticlymphoma
range includes: Basalcelladenocarcinoma
range includes: Basalcelladenoma
range includes: BasalcellcarcinomaNOS
range includes: Basalcellepithelioma
range includes: Basalcelltumor
range includes: Basophiladenocarcinoma
range includes: Basophiladenoma
range includes: Basophilcarcinoma
range includes: Bileductadenocarcinoma
range includes: Bileductadenoma
range includes: Bileductcarcinoma
range includes: Bileductcystadenocarcinoma
range includes: Bileductcystadenoma
range includes: Bronchialadenomacarcinoid
range includes: Bronchialadenomacylindroid
range includes: BronchialadenomaNOS
range includes: Bronchial-associatedlymphoidtissuelymphoma
range includes: Bronchio-alveolarcarcinomamixedmucinousandnon-mucinous
range includes: Bronchio-alveolarcarcinomamucinous
range includes: Bronchiolaradenocarcinoma
range includes: Bronchiolarcarcinoma
range includes: Bronchiolo-alveolaradenocarcinomaNOS
range includes: Bronchiolo-alveolarcarcinomaClaracell
range includes: Bronchiolo-alveolarcarcinomaClaracellandgobletcelltype
range includes: Bronchiolo-alveolarcarcinomagobletcelltype
range includes: Bronchiolo-alveolarcarcinomaindeterminatetype
range includes: Bronchiolo-alveolarcarcinomanon-mucinous

ProgressionorRecurrence
type: Class
comment: Yes/No/unknown indicator to identify whether a patient has had a new tumor event after initial treatment.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes-ProgressionorRecurrence
range includes: No
range includes: Unknown
range includes: NotReported
display name: Progression or Recurrence
required: sms:true

SiteofResectionorBiopsy
type: Class
comment: The text term used to describe the anatomic site of the resection or biopsy of the patient's malignant disease, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: AbdomenNOS
range includes: Abdominalesophagus
range includes: AccessorysinusNOS
range includes: Acousticnerve
range includes: AdrenalglandNOS
range includes: AmpullaofVater
range includes: Analcanal
range includes: Anterior2/3oftongueNOS
range includes: Anteriorfloorofmouth
range includes: Anteriormediastinum
range includes: Anteriorsurfaceofepiglottis
range includes: Anteriorwallofbladder
range includes: Anteriorwallofnasopharynx
range includes: AnusNOS
range includes: Aorticbodyandotherparaganglia
range includes: Appendix
range includes: Ascendingcolon
range includes: AutonomicnervoussystemNOS
range includes: Axillarytailofbreast
range includes: BaseoftongueNOS
range includes: Bladderneck
range includes: BladderNOS
range includes: Blood
range includes: Bodyofpancreas
range includes: Bodyofpenis
range includes: Bodyofstomach
range includes: Bonemarrow
range includes: BoneoflimbNOS
range includes: BoneNOS
range includes: Bonesofskullandfaceandassociatedjoints
range includes: Borderoftongue
range includes: Brainstem
range includes: BrainNOS
range includes: Branchialcleft
range includes: BreastNOS
range includes: Broadligament
range includes: CardiaNOS
range includes: Carotidbody
range includes: Caudaequina
range includes: Cecum
range includes: Centralportionofbreast
range includes: CerebellumNOS
range includes: Cerebralmeninges
range includes: Cerebrum
range includes: Cervicalesophagus
range includes: Cervixuteri
range includes: Choroid
range includes: Ciliarybody
range includes: Cloacogeniczone
range includes: ColonNOS
range includes: Commissureoflip
range includes: Conjunctiva
range includes: Connectivesubcutaneousandothersofttissuesofabdomen
range includes: Connectivesubcutaneousandothersofttissuesofheadfaceandneck
range includes: Connectivesubcutaneousandothersofttissuesoflowerlimbandhip
range includes: Connectivesubcutaneousandothersofttissuesofpelvis
range includes: Connectivesubcutaneousandothersofttissuesofthorax
range includes: ConnectivesubcutaneousandothersofttissuesoftrunkNOS
range includes: Connectivesubcutaneousandothersofttissuesofupperlimbandshoulder
range includes: ConnectivesubcutaneousandothersofttissuesNOS
range includes: CorneaNOS
range includes: Corpusuteri
range includes: Cortexofadrenalgland
range includes: CranialnerveNOS
range includes: Craniopharyngealduct
range includes: Descendedtestis
range includes: Descendingcolon
range includes: Domeofbladder
range includes: DorsalsurfaceoftongueNOS
range includes: Duodenum
range includes: Endocervix
range includes: EndocrineglandNOS
range includes: Endometrium
range includes: Epididymis
range includes: EsophagusNOS

TissueorOrganofOrigin
type: Class
comment: The text term used to describe the anatomic site of origin, of the patient's malignant disease, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: AbdomenNOS
range includes: Abdominalesophagus
range includes: AccessorysinusNOS
range includes: Acousticnerve
range includes: AdrenalglandNOS
range includes: AmpullaofVater
range includes: Analcanal
range includes: Anterior2/3oftongueNOS
range includes: Anteriorfloorofmouth
range includes: Anteriormediastinum
range includes: Anteriorsurfaceofepiglottis
range includes: Anteriorwallofbladder
range includes: Anteriorwallofnasopharynx
range includes: AnusNOS
range includes: Aorticbodyandotherparaganglia
range includes: Appendix
range includes: Ascendingcolon
range includes: AutonomicnervoussystemNOS
range includes: Axillarytailofbreast
range includes: BaseoftongueNOS
range includes: Bladderneck
range includes: BladderNOS
range includes: Blood
range includes: Bodyofpancreas
range includes: Bodyofpenis
range includes: Bodyofstomach
range includes: Bonemarrow
range includes: BoneoflimbNOS
range includes: BoneNOS
range includes: Bonesofskullandfaceandassociatedjoints
range includes: Borderoftongue
range includes: Brainstem
range includes: BrainNOS
range includes: Branchialcleft
range includes: BreastNOS
range includes: Broadligament
range includes: CardiaNOS
range includes: Carotidbody
range includes: Caudaequina
range includes: Cecum
range includes: Centralportionofbreast
range includes: CerebellumNOS
range includes: Cerebralmeninges
range includes: Cerebrum
range includes: Cervicalesophagus
range includes: Cervixuteri
range includes: Choroid
range includes: Ciliarybody
range includes: Cloacogeniczone
range includes: ColonNOS
range includes: Commissureoflip
range includes: Conjunctiva
range includes: Connectivesubcutaneousandothersofttissuesofabdomen
range includes: Connectivesubcutaneousandothersofttissuesofheadfaceandneck
range includes: Connectivesubcutaneousandothersofttissuesoflowerlimbandhip
range includes: Connectivesubcutaneousandothersofttissuesofpelvis
range includes: Connectivesubcutaneousandothersofttissuesofthorax
range includes: ConnectivesubcutaneousandothersofttissuesoftrunkNOS
range includes: Connectivesubcutaneousandothersofttissuesofupperlimbandshoulder
range includes: ConnectivesubcutaneousandothersofttissuesNOS
range includes: CorneaNOS
range includes: Corpusuteri
range includes: Cortexofadrenalgland
range includes: CranialnerveNOS
range includes: Craniopharyngealduct
range includes: Descendedtestis
range includes: Descendingcolon
range includes: Domeofbladder
range includes: DorsalsurfaceoftongueNOS
range includes: Duodenum
range includes: Endocervix
range includes: EndocrineglandNOS
range includes: Endometrium
range includes: Epididymis
range includes: EsophagusNOS

NCIAtlasCancerSite
type: Class
comment: The primary tumor site used to calculate the incidence rate using the NCI Cancer Atlas, a digital atlas which provides geographical data related to cancer utilizing the Surveillance, Epidemiology, and End Results (SEER) Program cancer incidence rates for 2013 to 2017
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Bladder
range includes: BrainAndOtherNervousSystem
range includes: FemaleBreast
range includes: InsituFemaleBreast
range includes: CervixUteri
range includes: LessThanAge
range includes: MalignantChildhoodNeoplasm
range includes: ColonAndRectum
range includes: Esophagus
range includes: KidneyAndRenalPelvis
range includes: Leukemia
range includes: LiverAndBileDuct
range includes: LungAndBronchus
range includes: CutaneousMelanoma
range includes: Non-Hodgkin'sLymphoma
range includes: OralCavityAndPharynx
range includes: Ovary
range includes: Pancreas
range includes: ProstateGland
range includes: Stomach
range includes: ThyroidGland
range includes: Uterus
display name: NCI Atlas Cancer Site
required: sms:false

TumorGrade
type: Class
comment: Numeric value to express the degree of abnormality of cancer cells, a measure of differentiation and aggressiveness.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: G1
range includes: G2
range includes: G3
range includes: G4
range includes: GX
range includes: GB
range includes: HighGrade
range includes: IntermediateGrade
range includes: LowGrade
range includes: Unknown
range includes: NotReported
range includes: NotApplicable
display name: Tumor Grade
required: sms:false

PackYearsSmoked
type: Class
comment: Numeric computed value to represent lifetime tobacco exposure defined as number of cigarettes smoked per day x number of years smoked divided by 20.
subclass of: Exposure
is part of: schema.biothings.io
display name: Pack Years Smoked
required: sms:true

YearsSmoked
type: Class
comment: Numeric value (or unknown) to represent the number of years a person has been smoking.
subclass of: Exposure
is part of: schema.biothings.io
display name: Years Smoked
required: sms:true

DaystoFollowUp
type: Class
comment: Number of days between the date used for index and the date of the patient's last follow-up appointment or contact. If not applicable please enter 'Not Applicable'
subclass of: FollowUp
is part of: schema.biothings.io
display name: Days to Follow Up
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

GeneSymbol
type: Class
comment: The text term used to describe a gene targeted or included in molecular analysis. For rearrangements, this is should be used to represent the reference gene. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Gene Symbol
required: sms:true

MolecularAnalysisMethod
type: Class
comment: The text term used to describe the method used for molecular analysis. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: ComparativeGenomicHybridization
range includes: CytogeneticsNOS
range includes: FISH
range includes: FlowCytometry
range includes: IHC
range includes: ISH
range includes: Karyotype
range includes: Microarray
range includes: MicrosatelliteAnalysis
range includes: NuclearStaining
range includes: Other
range includes: RNASequencing
range includes: RT-PCR
range includes: SequencingNOS
range includes: SouthernBlotting
range includes: TargetedSequencing
range includes: WGS
range includes: WXS
range includes: Unknown
range includes: NotReported
range includes: NotApplicable
display name: Molecular Analysis Method
required: sms:true

TestResult
type: Class
comment: The text term used to describe the result of the molecular test. If the test result was a numeric value see test_value. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: AbnormalNOS
range includes: CopyNumberReported
range includes: Equivocal
range includes: High
range includes: Intermediate
range includes: LossofExpression
range includes: Low
range includes: Negative
range includes: Normal
range includes: Overexpressed
range includes: Positive
range includes: TestValueReported
range includes: Unknown
range includes: NotReported
range includes: NotApplicable
display name: Test Result
required: sms:true

TreatmentType
type: Class
comment: Text term that describes the kind of treatment administered.
subclass of: Therapy
is part of: schema.biothings.io
range includes: AblationCryo
range includes: AblationEthanolInjection
range includes: AblationMicrowave
range includes: AblationNOS
range includes: AblationRadiofrequency
range includes: AblationRadiosurgical
range includes: AncillaryTreatment
range includes: AntiseizureTreatment
range includes: BisphosphonateTherapy
range includes: BlindedStudyTreatmentunknown
range includes: BrachytherapyHighDose
range includes: BrachytherapyLowDose
range includes: BrachytherapyNOS
range includes: Chemoembolization
range includes: Chemoprotectant
range includes: Chemotherapy
range includes: ConcurrentChemoradiation
range includes: Cryoablation
range includes: Embolization
range includes: EthanolInjectionAblation
range includes: ExternalBeamRadiation
range includes: HormoneTherapy
range includes: I-131RadiationTherapy
range includes: InternalRadiation
range includes: Immunotherapy(IncludingVaccines)
range includes: IsolatedLimbPerfusion(ILP)
range includes: OrganTransplantation
range includes: Other
range includes: PharmaceuticalTherapyNOS
range includes: Pleurodesis
range includes: Radiation2DConventional
range includes: Radiation3DConformal
range includes: RadiationCombination
range includes: RadiationCyberknife
range includes: RadiationExternalBeam
range includes: RadiationImplants
range includes: RadiationIntensity-ModulatedRadiotherapy
range includes: RadiationInternal
range includes: RadiationProtonBeam
range includes: RadiationRadioisotope
range includes: RadiationStereotactic/GammaKnife/SRS
range includes: RadiationSystemic
range includes: RadiationTherapyNOS
range includes: RadioactiveIodineTherapy
range includes: Radioembolization
range includes: RadiosensitizingAgent
range includes: StemCellTreatment
range includes: StemCellTransplantationAutologous
range includes: StemCellTransplantationDoubleAutologous
range includes: StemCellTransplantationAllogeneic
range includes: StemCellTransplantationNon-Myeloablative
range includes: StemCellTransplantationSyngenic
range includes: StemCellTransplantationHaploidentical
range includes: StemCellTransplantationNOS
range includes: StereotacticRadiosurgery
range includes: SteroidTherapy
range includes: Surgery
range includes: TargetedMolecularTherapy
range includes: Unknown
range includes: NotReported
display name: Treatment Type
required: sms:false
validation rules: list like

TumorLargestDimensionDiameter
type: Class
comment: Numeric value used to describe the maximum diameter or dimension of the primary tumor, measured in centimeters.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Tumor Largest Dimension Diameter
required: sms:false

LungCancerTier3
type: Class
comment: Lung cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Lung Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: LungCancerDetectionMethodType
requires dependency: LungCancerParticipantProcedureHistory
requires dependency: LungAdjacentHistologyType
requires dependency: LungTumorLocationAnatomicSite
requires dependency: LungTumorLobeBronchialLocation
requires dependency: CurrentLungCancerSymptoms
requires dependency: LungTopography
requires dependency: LungCancerHarboringGenomicAberrations

LungCancerDetectionMethodType
type: Class
comment: The means, manner of procedure, or systematic course of actions performed in order to discover or identify lung cancer
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: LowDoseComputedTomography(LDCT)
range includes: ChestX-ray
range includes: ChestCT
range includes: Unknown
range includes: Datanotavailable
range includes: Other
display name: Lung Cancer Detection Method Type
required: sms:false

LungCancerParticipantProcedureHistory
type: Class
comment: Text name of a surgical or operative procedure used in a natural history protocol of a lung cancer participant.
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: LobectomyBilateral
range includes: LobectomyLeft
range includes: LobectomyRight
range includes: LungWedgeResectionBilateral
range includes: LungWedgeResectionLeft
range includes: LungWedgeResectionMultiple
range includes: LungWedgeResectionRight
range includes: PneumonectomyLeft
range includes: PneumonectomyRight
range includes: Endobronchialbiopsy
range includes: Mediastinoscopy
range includes: VATSSclerosis
range includes: Brainresection
range includes: Segmentectomy
range includes: Unknown
range includes: Other
range includes: NotReported
display name: Lung Cancer Participant Procedure History
required: sms:false

LungAdjacentHistologyType
type: Class
comment: The type of morphologic characteristics observed by microscope in the tissue next to a benign or malignant tissue growth
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: Lungadenocarcinoma
range includes: Adenosquamouscarcinoma
range includes: Carcinoidtumorandlungatypicalcarcinoidtumor
range includes: Lungadenocarcinomainsitu
range includes: Largecelllungcarcinoma
range includes: Largecellneuroendocrinecarcinoma
range includes: Lunglymphoepithelioma-likecarcinoma
range includes: Bronchioalveolarcarcinoma
range includes: ThoracicNUTcarcinoma
range includes: Sarcomatoidcarcinoma
range includes: Smallcelllungcarcinoma
range includes: Squamouscelllungcarcinoma
range includes: Lungsquamouscellcarcinomainsitu
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Lung Adjacent Histology Type
required: sms:false

LungTumorLocationAnatomicSite
type: Class
comment: Anatomic location of the tumor inside the lung
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: Maincarina
range includes: Left
range includes: Right
range includes: Unknown
range includes: NotReported
display name: Lung Tumor Location Anatomic Site
required: sms:false

LungTumorLobeBronchialLocation
type: Class
comment: Anatomic lobe and bronchial location of the tumor inside the lung
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: Upperlobe
range includes: Middlelobe
range includes: Lowerlobe
range includes: Stump
range includes: Bronchus
range includes: Unknown
range includes: NotReported
display name: Lung Tumor Lobe Bronchial Location
required: sms:false

CurrentLungCancerSymptoms
type: Class
comment: Reported lung cancer related symptoms person is currently experiencing
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: Asbestosis
range includes: Productivecough
range includes: Non-productivecough
range includes: Wheezing
range includes: Rhonci
range includes: Crackles
range includes: Hemoptysis
range includes: Dyspnea
range includes: Unexplainedweightloss
range includes: fatigue
range includes: Chestpainordiscomfort
range includes: Dysphagia
range includes: Pneumonia
range includes: vocalcordinflammation
range includes: diminished
range includes: pooraeration
range includes: Shallowinspiration
range includes: Dullnesstopercussion
range includes: Abnormalbreathsounds
range includes: Clearlungstoauscultationorpercussion
range includes: normalbreathing
range includes: nasalcongestion
range includes: infection
range includes: Fingerclubbing
range includes: Noevidenceoflungcancerrecurrence
range includes: PatientisNED
range includes: forcedexpiratoryphase
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Current Lung Cancer Symptoms
required: sms:false

LungTopography
type: Class
comment: Lung PCA specific topography (not covered in previous tiers)
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: TR-Trachea(airwaywallbetweentracheo-esophagealbifurcationandmaincarina)
range includes: CarinaNOS(Carinanototherwisespecified)
range includes: LUDB-Carinabetweenthelingulaandupperdivisionleftupperlobe
range includes: CarinabetweenLUDBorificeandlingulaorifice
range includes: LUDB-orificeairwaywallbetweenLUDBandLB3(LB1+2carinae)
range includes: 5carinae
range includes: RLNOS(Rightlungnototherwisespecified)
range includes: B-CarinabetweenapicalandlateralsubsegmentssuperiorsegmentRLL
range includes: C-CarinabetweenapicalandmedialsubsegmentssuperiorsegmentRLL
range includes: C-CarinabetweenmedialandlateralsubsegmentssuperiorsegmentRLL
range includes: B-CarinabetweenmedialandlateralsubsegmentsmedialbasalsegmentRLL
range includes: B-CarinabetweenmedialandlateralsubsegmentsanteriorsegmentRLL
range includes: 10-CarinabetweenlateralandposteriorsegmentsRLL
range includes: B-CarinabetweenmedialandlateralsubsegmentslateralsegmentRLL
range includes: B-CarinabetweenmedialandlateralsubsegmentsposteriorsegmentRLL
range includes: C-CarinabetweenmedialandapicalsubsegmentsposteriorsegmentRLL
range includes: B-CarinabetweenmedialandlateralsubsegmentsapicalsegmentRUL
range includes: C-CarinabetweenmedialandlateralsubsegmentsposteriorsegmentRLL
range includes: Ccarinae
range includes: B-CarinabetweenthemedialandlateralsubsegmentsoftheanteriorsegmentRUL
range includes: B-Carinabetweenthemedialandlateralsubsegmentsofthelateralsegmentoftherightmiddlelobe
range includes: B-Carinabetweenthemedialandlateralsubsegmentsofthemedialsegmentoftherightmiddlelobe
range includes: RULCarinaebetweenRULorificeandbronchusintermedius
range includes: RB3
range includes: Bcarinae)
range includes: RML-CarinabetweenRMLorificeandRLLorifice
range includes: http://schema.biothings.io/RMLorificeAirwaywallbetweenRMLandRB4/5
range includes: RLLorificeAirwaywallbetweenRMLandRB6-10carinae
range includes: Bcarinae
range includes: LLNOS(Leftlungnototherwisespecified)
range includes: BCarinabetweenmedialandlateralsubsegmentssuperiorsegmentlingula
range includes: BCarinabetweenthemedialandlateralsubsegmentsinferiorsegmentlingula
range includes: BCarinabetweenthesuperiorandlateralsubsegmentssuperiorsegmentLLL
range includes: CCarinabetweenthesuperiorandmedialsubsegmentsofsuperiorsegmentLLL
range includes: CCarinabetweenthemedialandlateralsubsegmentsofthesuperiorsegmentLLL
range includes: BCarinabetweenthemedialandlateralsubsegmentsoftheanteriorsegmentLLL
range includes: BCarinabetweenthemedialandlateralsubsegmentsofthelateralsegmentLLL
range includes: BCarinabetweenthelateralandmedialsubsegmentsoftheapicalsegmentoftheLUL
range includes: BCarinabetweentheapicalandlateralsubsegmentsoftheposteriorsegmentoftheLLL
range includes: CCarinabetweentheapicalandmedialsegmentsoftheposteriorsegmentoftheLLL
range includes: CCarinabetweenthemedialandlateralsubsegmentsoftheposteriorsegmentoftheLLL
range includes: 3carinaandLB1orLB2)
range includes: CCarinabetweentheapicalandlateralsubsegmentsoftheapicalsegmentleftupperlobe
range includes: CCarinabetweenthemedialandlateralsubsegmentsoftheapicalsegmentoftheleftupperlobe
range includes: BCarinabetweentheapicalandlateralsubsegmentsoftheposteriorsegmentoftheleftupperlobe
range includes: CCarinabetweentheapicalandmedialsubsegmentsoftheposteriorsegmentoftheleftupperlobe
range includes: CCarinabetweenthemedialandlateralsubsegmentsoftheposteriorsegmentleftupperlobe
range includes: BCarinabetweentheapicalandlateralsubsegmentsoftheanteriorsegmentoftheleftupperlobe
range includes: LULorificeAirwaywallbetweenLULandLUDB
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Lung Topography
required: sms:false

LungCancerHarboringGenomicAberrations
type: Class
comment: Genomic aberrations in participants with lung cancer (specific lung cancer associated gene mutations not covered in Tiers 1 and 2)
subclass of: LungCancerTier3
is part of: schema.biothings.io
range includes: G12AKRASmutation
range includes: G12CKRASmutation
range includes: G12DKRASmutation
range includes: G12RKRASmutation
range includes: G12SKRASmutation
range includes: G12VKRASmutation
range includes: G13DKRASmutation
range includes: G13RKRASmutation
range includes: G13CKRASmutation
range includes: G13AKRASmutation
range includes: G13VKRASmutation
range includes: Q61LKRASmutation
range includes: Q61HKRASmutation
range includes: A146TKRASmutation
range includes: G719XEGFRmutation
range includes: T790MEGFRmutation
range includes: C797SEGFRmutation
range includes: L858REGFRmutation
range includes: L861QEGFRmutation
range includes: Exon19deletion
range includes: Exon20insertion
range includes: EML4-ALKtranslocation-variant1
range includes: EML4-ALKtranslocation-variant2
range includes: EML4-ALKtranslocation-variant3
range includes: EML4-ALKtranslocation-variant4
range includes: EML4-ALKtranslocation-variant5
range includes: V600EBRAFmutation
range includes: V600DBRAFmutation
range includes: V600KBRAFmutation
range includes: V600RBRAFmutation
range includes: K601EBRAFmutation
range includes: D963spliceMETmutation
range includes: D1010NMETmutation
range includes: D1010spliceMETmutation
range includes: Intron13mutation
range includes: Intron14mutation
range includes: Exon14mutation
range includes: Exon14deletion
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Lung Cancer Harboring Genomic Aberrations
required: sms:false

ColorectalCancerTier3
type: Class
comment: Colorectal cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Colorectal Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: ColorectalCancerDetectionMethodType
requires dependency: HistoryofPriorColonPolyps
requires dependency: FamilyColonCancerHistoryIndicator
requires dependency: FamilyMedicalHistoryColorectalPolypDiagnosis
requires dependency: ImmediateFamilyHistoryEndometrialCancer
requires dependency: ImmediateFamilyHistoryOvarianCancer
requires dependency: PatientInflammatoryBowelDiseasePersonalMedicaHistory
requires dependency: PatientColonoscopyPerformedIndicator
requires dependency: ColorectalCancerTumorBorderConfiguration
requires dependency: MLH1PromoterMethylationStatus
requires dependency: ColorectalCancerKRASIndicator
requires dependency: ColonPolypOccurenceIndicator
requires dependency: FamilyHistoryColorectalPolyp
requires dependency: ColorectalPolypNewIndicator
requires dependency: ColorectalPolypShape
requires dependency: SizeofPolypRemoved
requires dependency: ColorectalPolypCount
requires dependency: ColorectalPolypType
requires dependency: ColorectalPolypAdenomaType

ColorectalCancerDetectionMethodType
type: Class
comment: The means, manner of procedure, or systematic course of actions performed in order to discover or identify colorectal cancer
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Fecaloccultbloodtest
range includes: Sigmoidoscopy
range includes: Colonoscopy
range includes: Virtualcolonoscopy
range includes: DNAstooltest
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Colorectal Cancer Detection Method Type
required: sms:false

HistoryofPriorColonPolyps
type: Class
comment: Yes/No indicator to describe if the subject had a previous history of colon polyps as noted in the history/physical or previous endoscopic report (s).
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: NotApplicable
range includes: Unknown
display name: History of Prior Colon Polyps
required: sms:false

FamilyColonCancerHistoryIndicator
type: Class
comment: The indicator to designate if any first degree relative has a history of colorectal cancer.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: NotApplicable
range includes: Unknown
display name: Family Colon Cancer History Indicator
required: sms:false

FamilyMedicalHistoryColorectalPolypDiagnosis
type: Class
comment: A yes/no/unknown/not applicable indicator related to family medical history diagnosis of polypoid lesion that arises from the colon or rectum and protrudes into the lumen.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: NotApplicable
range includes: Unknown
display name: Family Medical History Colorectal Polyp Diagnosis
required: sms:false

ImmediateFamilyHistoryEndometrialCancer
type: Class
comment: Text that describes the age at which the family member was diagnosed with endometrial or uterine cancer in relationship to their 50th birthday.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Beforeage50
range includes: Notbeforeage50
range includes: Unknown
range includes: NotApplicable
display name: Immediate Family History Endometrial Cancer
required: sms:false

ImmediateFamilyHistoryOvarianCancer
type: Class
comment: Text that describes the age at which the family member was diagnosed with ovarian cancer in relationship to their 50th birthday.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Beforeage50
range includes: Notbeforeage50
range includes: Unknown
range includes: NotApplicable
display name: Immediate Family History Ovarian Cancer
required: sms:false

PatientInflammatoryBowelDiseasePersonalMedicaHistory
type: Class
comment: The indicator for patient's personal medical history of inflammatory bowel disease (chronic, non-specific disorders of unknown etiology, including Crohn disease and ulcerative colitis).
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes-Crohn'sdisease
range includes: Yes-Ulcerativecolitis
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Patient Inflammatory Bowel Disease Personal Medica History
required: sms:false

PatientColonoscopyPerformedIndicator
type: Class
comment: The yes/no indicator that records if the subject has undergone a previous colonoscopy.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: NotApplicable
range includes: Unknown
display name: Patient Colonoscopy Performed Indicator
required: sms:false

ColorectalCancerTumorBorderConfiguration
type: Class
comment: The description of the border configuration of a colorectal tumor at pathologic assessment.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Indeterminate
range includes: Infiltrating
range includes: Other
range includes: Pushing
range includes: NotApplicable
display name: Colorectal Cancer Tumor Border Configuration
required: sms:false

MLH1PromoterMethylationStatus
type: Class
comment: Text term to define the status of promoter methylation for the MLH1 gene. Note: MLH1 gene is commonly associated with hereditary nonpolyposis colorectal cancer. Testing for methylation of the MLH1 promoter can help distinguish sporadic from inherited cancers.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Absent
range includes: Indeterminate
range includes: NotAssessed
range includes: Present
display name: MLH1 Promoter Methylation Status
required: sms:false

ColorectalCancerKRASIndicator
type: Class
comment: The yes/no/not applicable indicator that describes if patient has diagnosis of colorectal cancer with known KRAS.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Colorectal Cancer KRAS Indicator
required: sms:false

ColonPolypOccurenceIndicator
type: Class
comment: Yes/No indicator to describe if the subject had a previous history of colon polyps as noted in the history/physical or previous endoscopic report (s).
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Colon Polyp Occurence Indicator
required: sms:false

FamilyHistoryColorectalPolyp
type: Class
comment: A yes/no/unknown/not applicable indicator related to family medical history diagnosis of polypoid lesion that arises from the colon or rectum and protrudes into the lumen.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Family History Colorectal Polyp
required: sms:false

ColorectalPolypNewIndicator
type: Class
comment: A yes/no response to a question that asks whether any new polyps greater or equal to two millimeter were identified.
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Colorectal Polyp New Indicator
required: sms:false

ColorectalPolypShape
type: Class
comment: Shape of polyp identified in the participant
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Pedunculated
range includes: Sessile
range includes: Flat
range includes: Notstated
range includes: NotApplicable
display name: Colorectal Polyp Shape
required: sms:false

SizeofPolypRemoved
type: Class
comment: Size of the polyp removed in cm
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
display name: Size of Polyp Removed
required: sms:false

ColorectalPolypCount
type: Class
comment: The total number of polyps detected
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
display name: Colorectal Polyp Count
required: sms:false

ColorectalPolypType
type: Class
comment: Type of polyp found in the participant
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Adenoma
range includes: Hyperplastic
range includes: Mixed
range includes: Papillomatous
range includes: Normal
range includes: Cancer
range includes: Other
range includes: Unknown
display name: Colorectal Polyp Type
required: sms:false

ColorectalPolypAdenomaType
type: Class
comment: Type of adenoma associated with the polyp
subclass of: ColorectalCancerTier3
is part of: schema.biothings.io
range includes: Tubular
range includes: Villous
range includes: Tubulovillous
range includes: Sessileserrated
range includes: Traditionalserrated
range includes: Serratednotspecified
range includes: Notstated
range includes: NotApplicable
display name: Colorectal Polyp Adenoma Type
required: sms:false

BreastCancerTier3
type: Class
comment: Breast cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Breast Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: BreastCarcinomaDetectionMethodType
requires dependency: BreastCarcinomaHistologyCategory
requires dependency: InvasiveLobularBreastCarcinomaHistologicCategory
requires dependency: InvasiveDuctalBreastCarcinomaHistologicCategory
requires dependency: BreastBiopsyProcedureFindingType
requires dependency: BreastQuadrantSite
requires dependency: BreastCancerAssessmentTests
requires dependency: BreastCancerGenomicTestPerformed
requires dependency: MammaprintRiskGroup
requires dependency: OncotypeRiskGroup
requires dependency: BreastCarcinomaEstrogenReceptorStatus
requires dependency: BreastCarcinomaProgesteronerReceptorStatus
requires dependency: BreastCancerAllredEstrogenReceptorScore
requires dependency: PriorInvasiveBreastDisease
requires dependency: BreastCarcinomaERStatusPercentageValue
requires dependency: BreastCarcinomaPRStatusPercentageValue
requires dependency: HER2BreastCarcinomaCopyNumberTotal
requires dependency: BreastCarcinomaCentromere17CopyNumber
requires dependency: BreastCarcinomaHER2Chromosome17Ratio
requires dependency: BreastCarcinomaSurgicalProcedureName
requires dependency: BreastCarcinomaHER2RatioDiagnosis
requires dependency: BreastCarcinomaHER2Status
requires dependency: HormoneTherapyBreastCancerPreventionIndicator
requires dependency: BreastCarcinomaERStainingIntensity
requires dependency: BreastCarcinomaPRStainingIntensity
requires dependency: OncotypeScore
requires dependency: BreastImagingPerformedType
requires dependency: MultifocalBreastCarcinomaPresentIndicator
requires dependency: MulticentricBreastCarcinomaPresentIndicator
requires dependency: BIRADSMammographyBreastDensityCategory

BreastCarcinomaDetectionMethodType
type: Class
comment: The means, manner of procedure, or systematic course of actions performed in order to discover or identify breast cancer.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: ClinicalExam
range includes: Datanotavailable
range includes: NippleDischarge
range includes: Other
range includes: ScreeningMammography
range includes: ScreeningMRI
range includes: Selfexam
range includes: Unknown
display name: Breast Carcinoma Detection Method Type
required: sms:false

BreastCarcinomaHistologyCategory
type: Class
comment: Classification of the type of invasive breast carcinoma diagnosed based on histologic attributes.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Infiltratingductalcarcinoma
range includes: Infiltratinglobularcarcinoma
range includes: InvasivemammarycarcinomaNOS
range includes: Invasivemixedductalandlobularcarcinoma
range includes: Other
display name: Breast Carcinoma Histology Category
required: sms:false

InvasiveLobularBreastCarcinomaHistologicCategory
type: Class
comment: The histologic subtype for an infiltrating lobular carcinoma of the breast.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Alveolartype
range includes: Classicaltype
range includes: Datanotavailable
range includes: Pleomorphictype
range includes: Unknown
display name: Invasive Lobular Breast Carcinoma Histologic Category
required: sms:false

InvasiveDuctalBreastCarcinomaHistologicCategory
type: Class
comment: The histologic subtype for the most common type of invasive breast carcinoma.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Classicaltype
range includes: Invasivecarcinoma-typecannotbedetermined
range includes: Invasivecribriformcarcinoma
range includes: Invasivemicropapillarycarcinoma
range includes: Invasivepapillarycarcinoma
range includes: Invasivetubularcarcinoma
range includes: Medullarycarcinoma
range includes: Mucinouscarcinoma
range includes: Tubulolobularcarcinoma
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Invasive Ductal Breast Carcinoma Histologic Category
required: sms:false

BreastBiopsyProcedureFindingType
type: Class
comment: Text term to describe the result of the examination of the breast tissue specimen or fluid as related to the presence and nature of disease.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Atypicalhyperplasia
range includes: DCIS
range includes: LCIS
range includes: Cancer
range includes: Nocancer
range includes: Other
display name: Breast Biopsy Procedure Finding Type
required: sms:false

BreastQuadrantSite
type: Class
comment: The breast quadrant or structure from which the breast tissue specimen was removed for microscopic examination.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Upperouterquadrant
range includes: Lowerouterquadrant
range includes: Upperinnerquadrant
range includes: Lowerinnerquadrant
range includes: Central
range includes: Nipple
range includes: Unknown
range includes: Datanotavailable
display name: Breast Quadrant Site
required: sms:false

BreastCancerAssessmentTests
type: Class
comment: Text term to identify assessment tests done in participants during diagnosis
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: EstrogenreceptorIHC
range includes: ProgesteronereceptorIHC
range includes: HER2IHC
range includes: HER2FISH-CISH
range includes: HER2FISH
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Breast Cancer Assessment Tests
required: sms:false

BreastCancerGenomicTestPerformed
type: Class
comment: Text term that represents the name of the genomic test performed for breast cancer.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Oncotype
range includes: MammaPrint
range includes: Other
range includes: Datanotavailable
range includes: Unknown
range includes: Notperformed
display name: Breast Cancer Genomic Test Performed
required: sms:false

MammaprintRiskGroup
type: Class
comment: Text term that represents the risk group for breast cancer as determined by assessment of the MammaPrint test.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Highrisk
range includes: Intermediaterisk
range includes: Lowrisk
range includes: Datanotavailable
range includes: Unknown
display name: Mammaprint Risk Group
required: sms:false

OncotypeRiskGroup
type: Class
comment: Text term that represents the risk group for breast cancer as determined by assessment of the Oncotype recurrence score.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Highrisk
range includes: Intermediaterisk
range includes: Lowrisk
range includes: Datanotavailable
range includes: Unknown
display name: Oncotype Risk Group
required: sms:false

BreastCarcinomaEstrogenReceptorStatus
type: Class
comment: Text term to represent the overall result of Estrogen Receptor (ER) testing in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Borderline
range includes: Equivocal
range includes: Indeterminate
range includes: Negative
range includes: NotPerformed
range includes: PerformedbutNotAvailable
range includes: Positive
range includes: Unknown
display name: Breast Carcinoma Estrogen Receptor Status
required: sms:false

BreastCarcinomaProgesteronerReceptorStatus
type: Class
comment: Text term to represent the overall result of Progresterone Receptor (PR) testing in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Borderline
range includes: Equivocal
range includes: Indeterminate
range includes: Negative
range includes: NotPerformed
range includes: PerformedbutNotAvailable
range includes: Positive
range includes: Unknown
display name: Breast Carcinoma Progesteroner Receptor Status
required: sms:false

BreastCancerAllredEstrogenReceptorScore
type: Class
comment: The numeric Allred score, that is cell staining percentage plus intensity, to determine estrogen receptor status.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: http://schema.biothings.io/0
range includes: 1
range includes: 2
range includes: 3
range includes: 4
range includes: http://schema.biothings.io/5
range includes: http://schema.biothings.io/6
range includes: http://schema.biothings.io/7
range includes: http://schema.biothings.io/8
range includes: http://schema.biothings.io/10
range includes: Unknown
display name: Breast Cancer Allred Estrogen Receptor Score
required: sms:false

PriorInvasiveBreastDisease
type: Class
comment: Text term to indicate prior invasive breast condition in the participant
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: DCIS
range includes: LCIS
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Prior Invasive Breast Disease
required: sms:false

BreastCarcinomaERStatusPercentageValue
type: Class
comment: A numerical quantity measured or assigned or computed which captures the estrogen receptor level measured in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma ER Status Percentage Value
required: sms:false

BreastCarcinomaPRStatusPercentageValue
type: Class
comment: A numerical quantity measured or assigned or computed which captures the progesterone receptor level measured in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma PR Status Percentage Value
required: sms:false

HER2BreastCarcinomaCopyNumberTotal
type: Class
comment: Result of HER2 Copy Number testing (in a participant with breast cancer), expressed as a range of values.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: HER2 Breast Carcinoma Copy Number Total
required: sms:false

BreastCarcinomaCentromere17CopyNumber
type: Class
comment: Result of Centromere 17 testing in a sample or specimen of metastatic breast carcinoma, expressed as a range of values.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma Centromere 17 Copy Number
required: sms:false

http://schema.biothings.io/BreastCarcinomaHER2Centromere17CopynumberTotal
type: Class
comment: Number of Cells Counted for HER2 & Centromere 17 Copy Numbers in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma HER2 Centromere17 Copynumber Total
required: sms:false

BreastCarcinomaHER2Chromosome17Ratio
type: Class
comment: HER2 chromosome 17 ratio in participants with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma HER2 Chromosome17 Ratio
required: sms:false

BreastCarcinomaSurgicalProcedureName
type: Class
comment: Text name of a surgical procedure performed for a person with a diagnosis of breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Lumpectomy
range includes: Radicalmastectomy
range includes: Modifiedradicalmastectomy
range includes: Other
range includes: Partialmastectomy
range includes: Re-excision
range includes: Simplemastectomy
range includes: Surgerynotperformed
range includes: Unknown
display name: Breast Carcinoma Surgical Procedure Name
required: sms:false

BreastCarcinomaHER2RatioDiagnosis
type: Class
comment: HER2 ratio of the participant at diagnosis
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Breast Carcinoma HER2 Ratio Diagnosis
required: sms:false

BreastCarcinomaHER2Status
type: Class
comment: Text term to signify the result of the medical procedure that involves testing a sample of blood or tissue for HER2 in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Positive
range includes: Negative
range includes: Amplified
range includes: Non-amplified
range includes: Equivocal
range includes: Indeterminate
range includes: NotPerformed
range includes: Unknown
display name: Breast Carcinoma HER2 Status
required: sms:false

HormoneTherapyBreastCancerPreventionIndicator
type: Class
comment: Did the patient receive hormonal therapy for prevention of breast cancer?
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotApplicable
display name: Hormone Therapy Breast Cancer Prevention Indicator
required: sms:false

BreastCarcinomaERStainingIntensity
type: Class
comment: Text term to indicate the ER staining intensity on pathology assessment in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Strong
range includes: Moderate
range includes: Weak
range includes: Weak-Moderate
range includes: Moderate-Strong
range includes: Weak-Strong
range includes: Other
range includes: Unknown
display name: Breast Carcinoma ER Staining Intensity
required: sms:false

BreastCarcinomaPRStainingIntensity
type: Class
comment: Text term to indicate the PR staining intensity on pathology assessment in a participant with breast cancer
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Strong
range includes: Moderate
range includes: Weak
range includes: Weak-Moderate
range includes: Moderate-Strong
range includes: Weak-Strong
range includes: Other
range includes: Unknown
display name: Breast Carcinoma PR Staining Intensity
required: sms:false

OncotypeScore
type: Class
comment: OncotypeDX recurrence score
subclass of: BreastCancerTier3
is part of: schema.biothings.io
display name: Oncotype Score
required: sms:false

BreastImagingPerformedType
type: Class
comment: The kind of technology or method performed for screening, diagnosis, surgical procedures or therapy that aids in the visualization of the breast(s).
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Mammogram
range includes: Ultrasound
range includes: MRI
range includes: CT
range includes: Multipleimagingmodalities
range includes: Unknown
range includes: Datanotavailable
display name: Breast Imaging Performed Type
required: sms:false

MultifocalBreastCarcinomaPresentIndicator
type: Class
comment: A response to indicate if there is breast cancer characterized by the presence of multiple cancerous tumors that originate from the same clone and usually located in the same quadrant of the breast.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: Datanotavailable
display name: Multifocal Breast Carcinoma Present Indicator
required: sms:false

MulticentricBreastCarcinomaPresentIndicator
type: Class
comment: A response to indicate if there is breast cancer characterized by the presence of multiple cancerous tumors that originate from different clones and usually located in different quadrants of the breast.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: Datanotavailable
display name: Multicentric Breast Carcinoma Present Indicator
required: sms:false

BIRADSMammographyBreastDensityCategory
type: Class
comment: The category that describes the relative amount of different tissues present in the breast on a mammogram based on the updated 2015 edition of the American College of Radiology's Breast Imaging Reporting and Data System (BI-RADS) reporting guidelines.
subclass of: BreastCancerTier3
is part of: schema.biothings.io
range includes: Predominantlyfatty
range includes: Scatteredfibroglandulardensities
range includes: Heterogeneouslydense
range includes: Extremelydense
range includes: Unknown
range includes: Datanotavailable
display name: BIRADS Mammography Breast Density Category
required: sms:false

NeuroblastomaandGliomaTier3
type: Class
comment: Brain cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Neuroblastoma and Glioma Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: CNSTumorPrimaryAnatomicSite
requires dependency: GliomaSpecificMetastasisSites
requires dependency: GliomaSpecificRadiationField
requires dependency: SupraTentorialEpendymomaMolecularSubgroup
requires dependency: InfraTentorialEpendymomaMolecularSubgroup
requires dependency: NeuroblastomaMYCNGeneAmplificationStatus

CNSTumorPrimaryAnatomicSite
type: Class
comment: Primary tumor location in the central nervous system that comprise the tissues of the central nervous system (brain and spinal cord)-not covered in Tiers 1 and 2
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: Thalamus
range includes: Ventricles
range includes: Leptomeningeal
range includes: Pituitary
range includes: Posteriorfossa
range includes: Brainstem-Medulla
range includes: Tectum
range includes: Brainstem-Pons
range includes: Spinalcord-Cervical
range includes: Spinalcord-Thoracic
range includes: Spinalcord-Lumbar
range includes: Opticpathway
range includes: OtherlocationsNOS
range includes: Paraspinalganglion
range includes: Basalganglia
range includes: Hippocampus
range includes: Dura
range includes: Otherlymphnodes
display name: CNS Tumor Primary Anatomic Site
required: sms:false

GliomaSpecificMetastasisSites
type: Class
comment: Evidence of active brain metastasis including leptomeningeal involvement
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: CSF
range includes: Spine
range includes: Bonemarrow
range includes: Brain
range includes: Other
range includes: Leptomeningeal
range includes: NotApplicable
display name: Glioma Specific Metastasis Sites
required: sms:false

GliomaSpecificRadiationField
type: Class
comment: A description of the location on or within the CNS where radiation was administered in a partcipant with glioma
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: Craniospinal
range includes: Focal-tumorbed
range includes: Unknown
range includes: NotApplicable
display name: Glioma Specific Radiation Field
required: sms:false

SupraTentorialEpendymomaMolecularSubgroup
type: Class
comment: Text term to identify the molecular subgroup in a supra tentorial ependymoma
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: ST-EPN-RELA
range includes: ST-EPN-YAP1
range includes: Unknown
range includes: NotApplicable
display name: Supra Tentorial Ependymoma Molecular Subgroup
required: sms:false

InfraTentorialEpendymomaMolecularSubgroup
type: Class
comment: Text term to identify the molecular subgroup in a infra tentorial ependymoma
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: PF-EPN-A
range includes: PF-EPN-B
range includes: Myxopapillaryependymoma
range includes: Unknown
range includes: NotApplicable
display name: Infra Tentorial Ependymoma Molecular Subgroup
required: sms:false

NeuroblastomaMYCNGeneAmplificationStatus
type: Class
comment: Neuroblastoma MYCN amplification or over-expression status
subclass of: NeuroblastomaandGliomaTier3
is part of: schema.biothings.io
range includes: Amplified
range includes: Notamplified
range includes: Notdone
range includes: Unknown
display name: Neuroblastoma MYCN Gene Amplification Status
required: sms:false

AcuteLymphoblasticLeukemiaTier3
type: Class
comment: Acute Lymphoblastic Leukemia attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Acute Lymphoblastic Leukemia Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: SpecimenBlastCountPercentageValue
requires dependency: NCIALLRiskGroup
requires dependency: MRDALLDiagnosticSensitivity
requires dependency: CNSLeukemiaStatus

SpecimenBlastCountPercentageValue
type: Class
comment: The value, in percent(%) of the medical procedure that involves testing a sample of blood for blast cells, immature (undifferentiated) cells during diagnosis
subclass of: AcuteLymphoblasticLeukemiaTier3
is part of: schema.biothings.io
display name: Specimen Blast Count Percentage Value
required: sms:false

NCIALLRiskGroup
type: Class
comment: The NCI risk group assigned to a patient at initial diagnosis with Acute Lymphoblastic Leukemia.
subclass of: AcuteLymphoblasticLeukemiaTier3
is part of: schema.biothings.io
range includes: NCIHighRisk
range includes: NCIStandardRisk
range includes: Unknown
display name: NCI ALL Risk Group
required: sms:false

MRDALLDiagnosticSensitivity
type: Class
comment: The assay sensitivity results of a diagnostic assessment of Minimal Residual Disease in patients diagnosed with Acute Lymphoblastic Leukemia.
subclass of: AcuteLymphoblasticLeukemiaTier3
is part of: schema.biothings.io
range includes: Optimal
range includes: Suboptimal
range includes: Indeterminate
range includes: Unknown
display name: MRD ALL Diagnostic Sensitivity
required: sms:false

CNSLeukemiaStatus
type: Class
comment: The status of central nervous system leukemia at the time of diagnosis.
subclass of: AcuteLymphoblasticLeukemiaTier3
is part of: schema.biothings.io
range includes: CNS1
range includes: CNS2
range includes: CNS3
range includes: CNS2a
range includes: CNS2b
range includes: CNS2c
range includes: CNS3a
range includes: CNS3b
range includes: CNS3c
range includes: Notevaluated
range includes: Unknown
display name: CNS Leukemia Status
required: sms:false

OvarianCancerTier3
type: Class
comment: Ovarian cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Ovarian Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: OvarianCancerHistologicSubtype
requires dependency: OvarianCancerSurgicalOutcome
requires dependency: OvarianCancerPlatinumStatus

OvarianCancerHistologicSubtype
type: Class
comment: Text term to describe the histological subtype of ovarian cancer in the participant
subclass of: OvarianCancerTier3
is part of: schema.biothings.io
range includes: High-gradeserous
range includes: Low-gradeserous
range includes: High-gradeendometrioid
range includes: Low-gradeendometrioid
range includes: Clearcell
range includes: Mucinous
range includes: Sex-cordstromal
range includes: Germcell
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Ovarian Cancer Histologic Subtype
required: sms:false

OvarianCancerSurgicalOutcome
type: Class
comment: Text term that describes the kind of surgical treatment administered.
subclass of: OvarianCancerTier3
is part of: schema.biothings.io
range includes: R0resection
range includes: Optimalcytoreduction
range includes: Sub-optimalcytoreduction
range includes: Other
range includes: Unknown
range includes: Datanotavailable
display name: Ovarian Cancer Surgical Outcome
required: sms:false

OvarianCancerPlatinumStatus
type: Class
comment: Text term to indicate the status of treatment with platinum in participant with ovarian cancer
subclass of: OvarianCancerTier3
is part of: schema.biothings.io
range includes: Platinum-refractory
range includes: Platinum-sensitive
range includes: Platinum-resistant
range includes: Datanotavailable
range includes: Unknown
display name: Ovarian Cancer Platinum Status
required: sms:false

ProstateCancerTier3
type: Class
comment: Prostate cancer specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Prostate Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: LocationExtentExtraprostaticExtension
requires dependency: LocationNaturePositiveMargins
requires dependency: SeminalVesicleInvasion
requires dependency: ProstateCarcinomaHistologicType
requires dependency: ProstateCancerLocalExtent
requires dependency: AdditonalFindingsUninvolvedProstate
requires dependency: ProstateCancerCytologicMorphologicSubtypes

LocationExtentExtraprostaticExtension
type: Class
comment: Location and extent of extraprostatic extension
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: LeftAnterior
range includes: LeftLateral
range includes: LeftPosterolateral
range includes: LeftPosterior
range includes: LeftApex
range includes: LeftMid
range includes: LeftBase
range includes: LeftFocal
range includes: LeftNon-focal(established)
range includes: RightAnterior
range includes: RightLateral
range includes: RightPosterolateral
range includes: RightPosterior
range includes: RightApex
range includes: RightMid
range includes: RightBase
range includes: RightFocal
range includes: RightNon-focal(established)
range includes: Unknown
range includes: NotReported
display name: Location Extent Extraprostatic Extension
required: sms:false

LocationNaturePositiveMargins
type: Class
comment: Location and nature of positive margins
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: LeftAnterior
range includes: LeftLateral
range includes: LeftPosterolateral
range includes: LeftPosterior
range includes: LeftApex
range includes: LeftMid
range includes: LeftBase
range includes: LeftFocal
range includes: LeftExtensive
range includes: LeftPositivewhereitisdifficulttodistinguishEPEvsII
range includes: RightAnterior
range includes: RightLateral
range includes: RightPosterolateral
range includes: RightPosterior
range includes: RightApex
range includes: RightMid
range includes: RightBase
range includes: RightFocal
range includes: RightExtensive
range includes: RightPositivewhereitisdifficulttodistinguishEPEvsII
range includes: Bladderneck(blockPUM)
range includes: Vasdeferens
range includes: Apicalmargin(blockDUM)
range includes: Unknown
range includes: NotReported
display name: Location Nature Positive Margins
required: sms:false

SeminalVesicleInvasion
type: Class
comment: An anatomic position identifying a side of the body where local spread of malignant neoplasm is found to infiltrate tissue in the saclike glandular diverticulum on the ductus deferens in a male.
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: None
range includes: Left
range includes: Right
range includes: Bothsides
range includes: Unknown
range includes: NotReported
display name: Seminal Vesicle Invasion
required: sms:false

ProstateCarcinomaHistologicType
type: Class
comment: The diagnostic subclassification of an invasive prostate carcinoma.
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: Prostaticductadenocarcinoma
range includes: Acinarprostateadenocarcinoma-signet-ringvariant
range includes: Prostaticadenosquamouscarcinoma
range includes: Acinarprostatemucinousadenocarcinoma
range includes: Prostaticsmallcellcarcinoma
range includes: Acinarprostateadenocarcinoma-sarcomatoidvariant
range includes: UndifferentiatedcarcinomaNOS
range includes: Other
display name: Prostate Carcinoma Histologic Type
required: sms:false

ProstateCancerLocalExtent
type: Class
comment: The response used to categorize the local extent of disease for prostate cancer.
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: OrganConfined
range includes: Extraprostaticextension
range includes: Unknown
range includes: NotReported
display name: Prostate Cancer Local Extent
required: sms:false

AdditonalFindingsUninvolvedProstate
type: Class
comment: Additional findings, uninvolved prostate
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: Inflammation
range includes: Benignprostatichyperplasia(BPH)
range includes: ProstaticIntraductaladenocarcinoma
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Additonal Findings Uninvolved Prostate
required: sms:false

ProstateCancerCytologicMorphologicSubtypes
type: Class
comment: Text term that describes various morphological and cytological subtypes in protate tumors.
subclass of: ProstateCancerTier3
is part of: schema.biothings.io
range includes: Prostaticbasalcellhyperplasia
range includes: Prostaticclearcellcribiformhyperplasia
range includes: (PINI)
range includes: (PINII&PINIII)
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Prostate Cancer Cytologic Morphologic Subtypes
required: sms:false

SarcomaTier3
type: Class
comment: Sarcoma specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Sarcoma Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: SarcomaSubtype
requires dependency: SarcomaDiagnosisClassificationCategory
requires dependency: SarcomaTumorExtensionType

SarcomaSubtype
type: Class
comment: The subtype related to the scientific determination and investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms of tissue growth resulting from uncontrolled cell proliferation.
subclass of: SarcomaTier3
is part of: schema.biothings.io
range includes: Undifferentiatedpleomorphicsarcoma
range includes: Leiomyosarcoma(uterineorextra-uterine)
range includes: OtherSynovialSarcomaOrMalignantPeripheralNerveSheathTumorSarcoma
range includes: GastrointestinalStromalTumor
range includes: Liposarcoma
range includes: Undifferentiatedpleomorphicsarcomaormalignantfibroushistiosarcoma
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Sarcoma Subtype
required: sms:false

SarcomaDiagnosisClassificationCategory
type: Class
comment: High level grouping to describe a diagnostic grouping or category for sarcoma, a malignant mesenchymal cell tumor most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels.
subclass of: SarcomaTier3
is part of: schema.biothings.io
range includes: BoneSarcoma
range includes: MusculoskeletalSarcoma
range includes: SoftTissueSarcoma
range includes: Unknown
range includes: NotReported
display name: Sarcoma Diagnosis Classification Category
required: sms:false

SarcomaTumorExtensionType
type: Class
comment: The field to indicate the organs and structures to which the tumor has become adherent or has invaded.
subclass of: SarcomaTier3
is part of: schema.biothings.io
range includes: Extraosseous
range includes: Intracranial
range includes: Lymphnodes
range includes: Parameningeal
range includes: Thoraciccavity
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Sarcoma Tumor Extension Type
required: sms:false

PancreaticCancerTier3
type: Class
comment: Pancreatic cancer specific attributes in Clinical Tier Data 3
subclass of: Patient
is part of: schema.biothings.io
display name: Pancreatic Cancer Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: PancreasPrecancerHistopathologicGrade
requires dependency: PancreaticIPMNPathologyEpithelialSubtype
requires dependency: PancreaticDuctFinalPathologyType

PancreasPrecancerHistopathologicGrade
type: Class
comment: The grade of precancerous pancreatic tissue based on microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.
subclass of: PancreaticCancerTier3
is part of: schema.biothings.io
range includes: IPMN-Adenoma
range includes: IPMN-Borderline
range includes: IPMN-Carcinomainsitu
range includes: IPMN-Invasivecarcinoma
range includes: PanIN1
range includes: PanIN1A
range includes: PanIN1B
range includes: PanIN2
range includes: PanIN3
range includes: Unknown
range includes: NotReported
display name: Pancreas Precancer Histopathologic Grade
required: sms:false

PancreaticIPMNPathologyEpithelialSubtype
type: Class
comment: The Intraductal Papillary Mucinous Neoplasm (IPMN) epithelial cell subtype based on the gross and microscopic examination of a pancreatic neoplasm specimen
subclass of: PancreaticCancerTier3
is part of: schema.biothings.io
range includes: GastricFoveolar
range includes: Intestinal
range includes: IntraductalTubopapillary
range includes: Pancreatobiliary
range includes: Oncocytic
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Pancreatic IPMN Pathology Epithelial Subtype
required: sms:false

PancreaticDuctFinalPathologyType
type: Class
comment: The final pathology result of the pancreatic duct communication type.
subclass of: PancreaticCancerTier3
is part of: schema.biothings.io
range includes: Side-Branch
range includes: MainDuct
range includes: Mixed
range includes: NotSpecified
range includes: None
range includes: NotReported
display name: Pancreatic Duct Final Pathology Type
required: sms:false

MelanomaTier3
type: Class
comment: Melanoma specific attributes in Clinical Data Tier 3
subclass of: Patient
is part of: schema.biothings.io
display name: Melanoma Tier 3
required: sms:false
requires dependency: Component
requires dependency: HTANParticipantID
requires dependency: TimepointLabel
requires dependency: StartDaysfromIndex
requires dependency: StopDaysfromIndex
requires dependency: CutaneousMelanomaTumorInfiltratingLymphocytes
requires dependency: CutaneousMelanomaTumorRegressionRange
requires dependency: MelanomaSpecimenClarkLevelValue
requires dependency: CutaneousMelanomaSurgicalMargins
requires dependency: MelanomaLesionSize
requires dependency: HistoryofAtypicalNevi
requires dependency: FitzpatrickSkinTone
requires dependency: HistoryofChronicUVExposure
requires dependency: HistoryofBlisteringSunburn
requires dependency: HistoryofTanningBedUse
requires dependency: ImmediateFamilyHistoryMelanoma
requires dependency: MelanomaBiopsyResectionSites
requires dependency: CutaneousMelanomaUlceration
requires dependency: CutaneousMelanomaAdditionalFindings

CutaneousMelanomaTumorInfiltratingLymphocytes
type: Class
comment: Description of degree of lymphocytic infiltration surrounding and disrupting tumor cells of the vertical growth phase in a cutaneous melanoma.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Absent
range includes: Brisk
range includes: Nonbrisk
range includes: Unknown
display name: Cutaneous Melanoma Tumor Infiltrating Lymphocytes
required: sms:false

CutaneousMelanomaTumorRegressionRange
type: Class
comment: Description of the degree to which tumor cells are replaced by lymphocytic inflammation with or without dermal melanophages and fibrosis._Range; the difference between the lowest and highest numerical values.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Absent
range includes: Presentinvolving75%ormore
range includes: Presentinvolvinglessthan75%
range includes: Unknown
display name: Cutaneous Melanoma Tumor Regression Range
required: sms:false

MelanomaSpecimenClarkLevelValue
type: Class
comment: Definition of the Clark level or depth of involvement of a melanoma in the skin or a specimen.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: I
range includes: II
range includes: III
range includes: IV
range includes: V
range includes: NoSourceDocumentation
range includes: Unknown
display name: Melanoma Specimen Clark Level Value
required: sms:false

CutaneousMelanomaSurgicalMargins
type: Class
comment: Text term to indicate presence of tumor at resection margins
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Positive
range includes: Negative
range includes: Unknown
range includes: NotReported
display name: Cutaneous Melanoma Surgical Margins
required: sms:false

MelanomaLesionSize
type: Class
comment: Diameter of lesion determined on skin examination (pre-bx), in mm
subclass of: MelanomaTier3
is part of: schema.biothings.io
display name: Melanoma Lesion Size
required: sms:false

HistoryofAtypicalNevi
type: Class
comment: Patient has a history of atypical nevi
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Yes(morethan50)
range includes: Yes(lessthan50)
range includes: No
range includes: Unknown
range includes: NotReported
display name: History of Atypical Nevi
required: sms:false

FitzpatrickSkinTone
type: Class
comment: The Fitzpatrick classification of skin phototype
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: I
range includes: II
range includes: III
range includes: IV
range includes: V
range includes: VI
range includes: Unknown
range includes: NotReported
display name: Fitzpatrick Skin Tone
required: sms:false

HistoryofChronicUVExposure
type: Class
comment: History of chronic UV exposure
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Outdooroccupational
range includes: Outdoorrecreational
range includes: Therapeutic
range includes: None
range includes: NotReported
display name: History of Chronic UV Exposure
required: sms:false

HistoryofBlisteringSunburn
type: Class
comment: Patient has history of blistering sunburn
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: History of Blistering Sunburn
required: sms:false

HistoryofTanningBedUse
type: Class
comment: History of tanning bed use of the patient
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Never
range includes: Lessthan10times
range includes: 10-50times
range includes: 50-100times
range includes: Morethan100times
range includes: NotReported
display name: History of Tanning Bed Use
required: sms:false

ImmediateFamilyHistoryMelanoma
type: Class
comment: Text that describes the age at which the family member was diagnosed with melanoma skin cancer in relationship to their 50th birthday.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Beforeage50
range includes: Notbeforeage50
range includes: Unknown
display name: Immediate Family History Melanoma
required: sms:false

MelanomaBiopsyResectionSites
type: Class
comment: Biopsy resection sites specific to melanoma (not covered in Tiers 1 and 2)
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Skinofscalp
range includes: Skinofeyelid
range includes: Skinofnose
range includes: Skinoflip
range includes: Skinofear
range includes: Skinofneck
range includes: Skinofotherpartsofface
range includes: Skinofchest
range includes: Skinofback
range includes: Skinofabdomen
range includes: Skinoftrunk-other
range includes: Skinofbreast
range includes: Skinofupperlimbandshoulder
range includes: Skinofpalm
range includes: Skinoflowerlimbandhip
range includes: Skinofsole
range includes: Skinofpenis
range includes: Skinofscrotum
range includes: Skinofvulva
range includes: Skinother
range includes: SkinNOS
range includes: NotReported
display name: Melanoma Biopsy Resection Sites
required: sms:false

CutaneousMelanomaUlceration
type: Class
comment: Description of extent of disruption to the surface of the skin caused by the cutaneous melanoma.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: Absent
range includes: Present
range includes: Unknown
range includes: NotReported
display name: Cutaneous Melanoma Ulceration
required: sms:false

CutaneousMelanomaAdditionalFindings
type: Class
comment: Significant pathologic finding present in addition to the cutaneous melanoma.
subclass of: MelanomaTier3
is part of: schema.biothings.io
range includes: ActinicKeratosis
range includes: NevusRemnant
range includes: SolarElastosis
range includes: FibrosingRegression
range includes: NestingMelanoma
range includes: PagetoidSpread
range includes: VascularProliferation
range includes: Other
range includes: Unknown
range includes: NotApplicable
display name: Cutaneous Melanoma Additional Findings
required: sms:false

DaystoBirth
type: Class
comment: Number of days between the date used for index and the date from a person's date of birth represented as a calculated negative number of days. If not applicable please enter 'Not Applicable'
subclass of: Demographics
is part of: schema.biothings.io
display name: Days to Birth
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

CountryofResidence
type: Class
comment: Country of Residence at enrollment
subclass of: Demographics
is part of: schema.biothings.io
range includes: Afghanistan
range includes: Albania
range includes: Algeria
range includes: Andorra
range includes: Angola
range includes: Anguilla
range includes: AntiguaandBarbuda
range includes: Argentina
range includes: Armenia
range includes: Aruba
range includes: Australia
range includes: Austria
range includes: Azerbaijan
range includes: Bahamas
range includes: Bahrain
range includes: Bangladesh
range includes: Barbados
range includes: Belarus
range includes: Belgium
range includes: Belize
range includes: Benin
range includes: Bermuda
range includes: Bhutan
range includes: Bolivia
range includes: BosniaandHerzegovina
range includes: Botswana
range includes: Brazil
range includes: Brunei
range includes: Bulgaria
range includes: BurkinaFaso
range includes: Burundi
range includes: Cambodia
range includes: Cameroon
range includes: Canada
range includes: CapeVerde
range includes: CaymanIslands
range includes: CentralAfricanRepublic
range includes: Chad
range includes: Chile
range includes: China
range includes: Colombia
range includes: Comoros
range includes: Congo
range includes: CookIslands
range includes: CostaRica
range includes: Coted'Ivoire
range includes: Croatia
range includes: Cuba
range includes: Curacao
range includes: Cyprus
range includes: CzechRepublic(Czechia)
range includes: DemocraticRepublicoftheCongo
range includes: Denmark
range includes: Djibouti
range includes: Dominica
range includes: DominicanRepublic
range includes: Ecuador
range includes: Egypt
range includes: ElSalvador
range includes: EquatorialGuinea
range includes: Eritrea
range includes: Estonia
range includes: Eswatini
range includes: Ethiopia
range includes: FalklandIslands(Malvinas)
range includes: FaroeIslands
range includes: FederatedStatesofMicronesia
range includes: Fiji
range includes: Finland
range includes: France
range includes: FrenchGuiana
range includes: FrenchPolynesia
range includes: Gabon
range includes: Gambia
range includes: Georgia

AgeIsObfuscated
type: Class
comment: The age of the patient has been modified for compliance reasons. The actual age differs from what is reported. Other date intervals for this patient may also be modified.
subclass of: Demographics
is part of: schema.biothings.io
range includes: True
range includes: False
display name: Age Is Obfuscated
required: sms:false

YearOfBirth
type: Class
comment: Numeric value to represent the calendar year in which an individual was born.
subclass of: Demographics
is part of: schema.biothings.io
display name: Year Of Birth
required: sms:false

OccupationDurationYears
type: Class
comment: The number of years a patient worked in a specific occupation.
subclass of: Demographics
is part of: schema.biothings.io
display name: Occupation Duration Years
required: sms:false

PrematureAtBirth
type: Class
comment: The yes/no/unknown indicator used to describe whether the patient was premature (less than 37 weeks gestation) at birth.
subclass of: Demographics
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Premature At Birth
required: sms:false

WeeksGestationatBirth
type: Class
comment: Numeric value used to describe the number of weeks starting from the approximate date of the biological mother's last menstrual period and ending with the birth of the patient.
subclass of: Demographics
is part of: schema.biothings.io
display name: Weeks Gestation at Birth
required: sms:false

RelativewithCancerHistory
type: Class
comment: The yes/no/unknown indicator used to describe whether any of the patient's relatives have a history of cancer.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: Yes-CancerHistoryRelative
range includes: None
range includes: Unknown
range includes: NotReported
display name: Relative with Cancer History
required: sms:false

SmokingExposure
type: Class
comment: Indicate if individual has smoking exposure
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes-SmokingExposure
range includes: No-SmokingExposure
range includes: NotReported
display name: Smoking Exposure
required: sms:true

AlcoholExposure
type: Class
comment: Indicate if individual has alcohol exposure
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes-AlcoholExposure
range includes: No-AlcoholExposure
range includes: NotReported
display name: Alcohol Exposure
required: sms:true

AsbestosExposure
type: Class
comment: The yes/no/unknown indicator used to describe whether the patient was exposed to asbestos.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Asbestos Exposure
required: sms:false

CoalDustExposure
type: Class
comment: The yes/no/unknown indicator used to describe whether a patient was exposed to fine powder derived by the crushing of coal.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
display name: Coal Dust Exposure
required: sms:false

EnvironmentalTobaccoSmokeExposure
type: Class
comment: The yes/no/unknown indicator used to describe whether a patient was exposed to smoke that is emitted from burning tobacco, including cigarettes, pipes, and cigars. This includes tobacco smoke exhaled by smokers.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
display name: Environmental Tobacco Smoke Exposure
required: sms:false

RadonExposure
type: Class
comment: The yes/no/unknown indicator used to describe whether the patient was exposed to radon.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Radon Exposure
required: sms:false

RespirableCrystallineSilicaExposure
type: Class
comment: The yes/no/unknown indicator used to describe whether a patient was exposured to respirable crystalline silica, a widespread, naturally occurring, crystalline metal oxide that consists of different forms including quartz, cristobalite, tridymite, tripoli, ganister, chert and novaculite.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
display name: Respirable Crystalline Silica Exposure
required: sms:false

AdverseEvent
type: Class
comment: Text that represents the Common Terminology Criteria for Adverse Events low level term name for an adverse event.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AbdominalDistension
range includes: AbdominalInfection
range includes: AbdominalPain
range includes: AbdominalSoftTissueNecrosis
range includes: AbducensNerveDisorder
range includes: AccessoryNerveDisorder
range includes: Acidosis
range includes: AcousticNerveDisorderNOS
range includes: ActivatedPartialThromboplastinTimeProlonged
range includes: AcuteCoronarySyndrome
range includes: AcuteKidneyInjury
range includes: AdrenalInsufficiency
range includes: AdultRespiratoryDistressSyndrome
range includes: Agitation
range includes: Akathisia
range includes: AlanineAminotransferaseIncreased
range includes: AlcoholIntolerance
range includes: AlkalinePhosphataseIncreased
range includes: Alkalosis
range includes: AllergicReaction
range includes: AllergicRhinitis
range includes: Alopecia
range includes: Amnesia
range includes: AnalFistula
range includes: AnalHemorrhage
range includes: AnalMucositis
range includes: AnalNecrosis
range includes: AnalPain
range includes: AnalStenosis
range includes: AnalUlcer
range includes: Anaphylaxis
range includes: Anemia
range includes: AnkleFracture
range includes: AnorectalInfection
range includes: Anorexia
range includes: Anorgasmia
range includes: Anxiety
range includes: AorticInjury
range includes: AorticValveDisease
range includes: Aphonia
range includes: Apnea
range includes: Appendicitis
range includes: AppendicitisPerforated
range includes: Arachnoiditis
range includes: ArterialInjury
range includes: ArteritisInfective
range includes: Arthralgia
range includes: Arthritis
range includes: Ascites
range includes: AspartateAminotransferaseIncreased
range includes: Aspiration
range includes: Asystole
range includes: Ataxia
range includes: Atelectasis
range includes: AtrialFibrillation
range includes: AtrialFlutter
range includes: AtrioventricularBlockComplete
range includes: AtrioventricularBlockFirstDegree
range includes: AutoimmuneDisorder
range includes: AvascularNecrosis
range includes: Azoospermia
range includes: BackPain
range includes: BileDuctStenosis
range includes: BiliaryAnastomoticLeak
range includes: BiliaryFistula
range includes: BiliaryTractInfection
range includes: BladderAnastomoticLeak
range includes: BladderInfection
range includes: BladderPerforation
range includes: BladderSpasm
range includes: Bloating
range includes: BloodandLymphaticSystemDisordersOther
range includes: BloodAntidiureticHormoneAbnormal
range includes: BloodBilirubinIncreased
range includes: BloodCorticotrophinDecreased

BarrettsEsophagusGobletCellsPresent
type: Class
comment: Presence or absennce of Barretts esophagus goblet cells.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Barretts Esophagus Goblet Cells Present
required: sms:false

BMI
type: Class
comment: A calculated numerical quantity that represents an individual's weight to height ratio.
subclass of: FollowUp
is part of: schema.biothings.io
display name: BMI
required: sms:false

CauseofResponse
type: Class
comment: The text term used to describe the suspected cause or reason for the patient disease response.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Cause of Response
required: sms:false

Comorbidity
type: Class
comment: The text term used to describe a comorbidity disease, which coexists with the patient's malignant disease.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AcuteRenalFailure
range includes: Adenocarcinoma
range includes: AdrenocorticalInsufficiency
range includes: AdenomatousPolyposisColi
range includes: Allergies
range includes: Alpha-1Antitrypsin
range includes: Anemia
range includes: Anxiety
range includes: Arrhythmia
range includes: Arthritis
range includes: Asthma
range includes: AtrialFibrillation
range includes: AvascularNecrosis
range includes: Barrett'sEsophagus
range includes: BasalCellCarcinoma
range includes: Beckwith-Wiedemann
range includes: Behcet'sDisease
range includes: BiliaryDisorder
range includes: BloodClots
range includes: BoneFracture(s)
range includes: Bronchitis
range includes: CalciumChannelBlockers
range includes: Cancer
range includes: Cataracts
range includes: CeliacDisease
range includes: Cirrhosis
range includes: UnknownEtiology
range includes: CerebrovascularDisease
range includes: Cholelithiasis
range includes: ChronicRenalFailure
range includes: ColonPolyps
range includes: CommonVariableImmunodeficiency
range includes: CongestiveHeartFailure(CHF)
range includes: ConnectiveTissueDisorder
range includes: COPD
range includes: CoronaryArteryDisease
range includes: Crohn'sDisease
range includes: CryptogenicOrganizingPneumonia
range includes: DeepVeinThrombosis/Thromboembolism
range includes: Denys-DrashSyndrome
range includes: Depression
range includes: Diabetes
range includes: TypeII
range includes: DiabeticNeuropathy
range includes: DietControlledDiabetes
range includes: Diverticulitis
range includes: DVT/PE
range includes: Dyslipidemia
range includes: Epilepsy
range includes: Eczema
range includes: Epstein-BarrVirus
range includes: FamilialAdenomatousPolyposis
range includes: FanconiAnemia
range includes: Fibrosis
range includes: GastroesophagealRefluxDisease
range includes: GERD
range includes: Glaucoma
range includes: GlycogenStorageDisease
range includes: Gout
range includes: GonadalDysfunction
range includes: GorlinSyndrome
range includes: H.pyloriInfection
range includes: Hashimoto'sThyroiditis
range includes: Headache
range includes: HeartDisease
range includes: Hemihypertrophy
range includes: HemorrhagicCystitis
range includes: Hepatitis
range includes: HepatitisAInfection
range includes: HepatitisBInfection
range includes: HepatitisCInfection
range includes: ChronicHepatitis
range includes: HereditaryNon-polyposisColonCancer
range includes: Herpes
range includes: HighGradeLiverDysplasticNodule

ComorbidityMethodofDiagnosis
type: Class
comment: The text term used to describe the method used to diagnose the patient's comorbidity disease.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Histology
range includes: Pathology
range includes: Radiology
range includes: Unknown
range includes: NotReported
display name: Comorbidity Method of Diagnosis
required: sms:false

DaystoAdverseEvent
type: Class
comment: Number of days between the date used for index and the date of the patient's adverse event. If not applicable please enter 'Not Applicable'
subclass of: FollowUp
is part of: schema.biothings.io
display name: Days to Adverse Event
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

DaystoComorbidity
type: Class
comment: Number of days between the date used for index and the date the patient was diagnosed with a comorbidity. If not applicable please enter 'Not Applicable'
subclass of: FollowUp
is part of: schema.biothings.io
display name: Days to Comorbidity
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

DiabetesTreatmentType
type: Class
comment: Text term used to describe the types of treatment used to manage diabetes.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Alpha-GlucosidaseInhibitor
range includes: Biguanide
range includes: Diet
range includes: InjectedInsulin
range includes: Insulin
range includes: OralHypoglycemic
range includes: Sulfonylurea
range includes: Thiazolidinedione
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Diabetes Treatment Type
required: sms:false

DiseaseResponse
type: Class
comment: Code assigned to describe the patient's response or outcome to the disease.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AJ-AdjuvantTherapy
range includes: BED-BiochemicalEvidenceofDisease
range includes: CPD-ClinicalProgression
range includes: CR-CompleteResponse
range includes: CRU-CompleteResponseUnconfirmed
range includes: DU-DiseaseUnchanged
range includes: IMR-Immunoresponse
range includes: IPD-Immunoprogression
range includes: MR-Minimal/Marginalresponse
range includes: MX-MixedResponse
range includes: Non-CR/Non-PD-Non-CR/Non-PD
range includes: NPB-NoPalliativeBenefit
range includes: NR-NoResponse
range includes: PA-PalliativeTherapy
range includes: PB-PalliativeBenefit
range includes: PD-ProgressiveDisease
range includes: PDM-PersistentDistantMetastasis
range includes: PLD-PersistentLocoregionalDisease
range includes: PPD-Pseudoprogression
range includes: PR-PartialResponse
range includes: PSR-Pseudoresponse
range includes: RD-ResponsiveDisease
range includes: RP-Response
range includes: RPD-RadiographicProgressiveDisease
range includes: SCR-StringentCompleteResponse
range includes: SD-StableDisease
range includes: SPD-SurgicalProgression
range includes: TE-TooEarly
range includes: TF-TumorFree
range includes: VGPR-VeryGoodPartialResponse
range includes: WT-WithTumor
range includes: Unknown
range includes: NotReported
display name: Disease Response
required: sms:false

DLCORefPredictivePercent
type: Class
comment: The value, as a percentage of predicted lung volume, measuring the amount of carbon monoxide detected in a patient's lungs.
subclass of: FollowUp
is part of: schema.biothings.io
display name: DLCO Ref Predictive Percent
required: sms:false

ECOGPerformanceStatus
type: Class
comment: The ECOG functional performance status of the patient/participant.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: "0"
range includes: "1"
range includes: "2"
range includes: "3"
range includes: "4"
range includes: "5"
range includes: "0.0"
range includes: "1.0"
range includes: "2.0"
range includes: "3.0"
range includes: "4.0"
range includes: "5.0"
range includes: Unknown
range includes: NotReported
display name: ECOG Performance Status
required: sms:false

FEV1FVCPostBronchPercent
type: Class
comment: Percentage value to represent result of Forced Expiratory Volume in 1 second (FEV1) divided by the Forced Vital Capacity (FVC) post-bronchodilator.
subclass of: FollowUp
is part of: schema.biothings.io
display name: FEV1 FVC Post Bronch Percent
required: sms:false

FEV1FVCPreBronchPercent
type: Class
comment: Percentage value to represent result of Forced Expiratory Volume in 1 second (FEV1) divided by the Forced Vital Capacity (FVC) pre-bronchodilator.
subclass of: FollowUp
is part of: schema.biothings.io
display name: FEV 1 FVC Pre Bronch Percent
required: sms:false

FEV1RefPostBronchPercent
type: Class
comment: The percentage comparison to a normal value reference range of the volume of air that a patient can forcibly exhale from the lungs in one second post-bronchodilator.
subclass of: FollowUp
is part of: schema.biothings.io
display name: FEV1 Ref Post Bronch Percent
required: sms:false

FEV1RefPreBronchPercent
type: Class
comment: The percentage comparison to a normal value reference range of the volume of air that a patient can forcibly exhale from the lungs in one second pre-bronchodilator.
subclass of: FollowUp
is part of: schema.biothings.io
display name: FEV1 Ref Pre Bronch Percent
required: sms:false

Height
type: Class
comment: The height of the patient in centimeters.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Height
required: sms:false

HepatitisSustainedVirologicalResponse
type: Class
comment: The yes/no/unknown indicator used to describe whether the patient received treatment for a risk factor the patient had at the time of or prior to their diagnosis.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Hepatitis Sustained Virological Response
required: sms:false

HPVPositiveType
type: Class
comment: Text classification to represent the strain or type of human papillomavirus identified in an individual.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: "16"
range includes: "18"
range includes: "26"
range includes: "31"
range includes: "33"
range includes: "35"
range includes: "39"
range includes: "45"
range includes: "51"
range includes: "52"
range includes: "53"
range includes: "56"
range includes: "58"
range includes: "59"
range includes: "63"
range includes: "66"
range includes: "68"
range includes: "70"
range includes: "73"
range includes: "82"
range includes: Other
range includes: Unknown
range includes: NotReported
display name: HPV Positive Type
required: sms:false

KarnofskyPerformanceStatus
type: Class
comment: Text term used to describe the classification used of the functional capabilities of a person.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: "0"
range includes: "10"
range includes: "20"
range includes: "30"
range includes: "40"
range includes: "50"
range includes: "60"
range includes: "70"
range includes: "80"
range includes: "90"
range includes: "100"
range includes: Unknown
range includes: NotReported
display name: Karnofsky Performance Status
required: sms:false

MenopauseStatus
type: Class
comment: Text term used to describe the patient's menopause status.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Premenopausal
range includes: Perimenopausal
range includes: Postmenopausal
range includes: Unknown
range includes: NotReported
display name: Menopause Status
required: sms:false

PancreatitisOnsetYear
type: Class
comment: Date of onset of pancreatitis.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Pancreatitis Onset Year
required: sms:false
validation rules: num

RefluxTreatmentType
type: Class
comment: Text term used to describe the types of treatment used to manage gastroesophageal reflux disease (GERD).
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Antacids
range includes: H2Blockers
range includes: MedicallyTreated
range includes: NoTreatment
range includes: NotApplicable
range includes: NotReported
range includes: ProtonPumpInhibitors
range includes: SurgicallyTreated
range includes: Unknown
display name: Reflux Treatment Type
required: sms:false

RiskFactor
type: Class
comment: The text term used to describe a risk factor the patient had at the time of or prior to their diagnosis.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AlcoholConsumption
range includes: AlcoholicLiverDisease
range includes: AllergyAnimalNOS
range includes: AllergyAnt
range includes: AllergyBee
range includes: AllergyCat
range includes: AllergyDairyorLactose
range includes: AllergyDog
range includes: AllergyEggs
range includes: AllergyFoodNOS
range includes: AllergyFruit
range includes: AllergyMeat
range includes: AllergyMoldorDust
range includes: AllergyNuts
range includes: AllergyProcessedFoods
range includes: AllergySeafood
range includes: AllergyWasp
range includes: Alpha-1AntitrypsinDeficiency
range includes: AutoimmuneAtrophicChronicGastritis
range includes: Barrett'sEsophagus
range includes: Beckwith-Wiedemann
range includes: Behcet'sDisease
range includes: Cancer
range includes: Cholelithiasis
range includes: ChronicHepatitis
range includes: Cirrhosis
range includes: ColonPolyps
range includes: Commonvariableimmunedeficiency(CVID)
range includes: Denys-DrashSyndrome
range includes: DiabetesNOS
range includes: DiabetesTypeI
range includes: DiabetesTypeII
range includes: Diet
range includes: Diverticulitis
range includes: Endometriosis
range includes: Endosalpingiosis
range includes: Eczema
range includes: Epstein-BarrVirus
range includes: FamilialAdenomatousPolyposis
range includes: FanconiAnemia
range includes: Fibrosis
range includes: GastricPolyp(s)
range includes: Gilbert'sSyndrome
range includes: GorlinSyndrome
range includes: Hashimoto'sThyroiditis
range includes: HayFever
range includes: Headache
range includes: HelicobacterPylori-AssociatedGastritis
range includes: HematologicDisorderNOS
range includes: Hemihypertrophy
range includes: Hemochromatosis
range includes: HepaticEncephalopathy
range includes: HepatitisBInfection
range includes: HepatitisCInfection
range includes: HepatitisNOS
range includes: HighGradeDysplasia
range includes: HIV
range includes: HumanPapillomavirusInfection
range includes: Hypospadias
range includes: IntestinalMetaplasia
range includes: IronOverload
range includes: Li-FraumeniSyndrome
range includes: LowGradeDysplasia
range includes: LymphocyticThyroiditis
range includes: LynchSyndrome
range includes: MyastheniaGravis
range includes: NonalcoholicFattyLiverDisease
range includes: NonalcoholicSteatohepatitis
range includes: Obesity
range includes: OralContraceptives
range includes: Pancreatitis
range includes: ParasiticDiseaseofBiliaryTract
range includes: PrimarySclerosingCholangitis
range includes: RecurrentPyogenicCholangitis
range includes: RefluxDisease

RiskFactorTreatment
type: Class
comment: The yes/no/unknown indicator used to describe whether the patient received treatment for a risk factor the patient had at the time of or prior to their diagnosis.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Risk Factor Treatment
required: sms:false

ViralHepatitisSerologies
type: Class
comment: Text term that describes the kind of serological laboratory test used to determine the patient's hepatitus status.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: HBVCoreAntibody
range includes: HBVDNA
range includes: HBVGenotype
range includes: HBVSurfaceAntibody
range includes: HCVGenotype
range includes: HepatitisBSurfaceAntigen
range includes: HepatitisCAntibody
range includes: HepatitisCVirusRNA
range includes: Unknown
range includes: NotReported
display name: Viral Hepatitis Serologies
required: sms:false

Weight
type: Class
comment: The weight of the patient measured in kilograms.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Weight
required: sms:false

AdverseEventGrade
type: Class
comment: The text term used to describe a specific histone variants, which are proteins that substitute for the core canonical histones.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Grade1
range includes: Grade2
range includes: Grade3
range includes: Grade4
range includes: Grade5
display name: Adverse Event Grade
required: sms:false

AIDSRiskFactors
type: Class
comment: The text term used to describe a risk factor of the acquired immunodeficiency syndrome (AIDS) that the patient either had at time time of the study or experienced in the past.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Candidiasis
range includes: Coccidioidomycosis
range includes: Cryptococcosis
range includes: Cytomegalovirus
range includes: Encephalopathy
range includes: HerpesSimplexVirus
range includes: Histoplasmosis
range includes: Isosporiasis
range includes: MycobacteriumaviumComplex
range includes: Mycobacteriumtuberculosis
range includes: Mycobacterium
range includes: NOS
range includes: Nocardiosis
range includes: PneumocystisPneumonia
range includes: Pneumonia
range includes: ProgressiveMultifocalLeukoencephalopathy
range includes: SalmonellaSepticemia
range includes: Toxoplasmosis
range includes: WastingSyndrome
display name: AIDS Risk Factors
required: sms:false

BodySurfaceArea
type: Class
comment: Numeric value used to represent the 2-dimensional extent of the body surface relating height to weight.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Body Surface Area
required: sms:false

CD4Count
type: Class
comment: The text term used to describe the outcome of the procedure to determine the amount of the CD4 expressing cells in a sample.
subclass of: FollowUp
is part of: schema.biothings.io
display name: CD4 Count
required: sms:false

CDCHIVRiskFactors
type: Class
comment: The text term used to describe a risk factor for human immunodeficiency virus, as described by the Center for Disease Control.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Hemophiliac
range includes: HeterosexualContact
range includes: HomosexualContact
range includes: IntravenousDrugUser
range includes: None
range includes: TransfusionRecipient
range includes: Unknown
range includes: NotReported
display name: CDC HIV Risk Factors
required: sms:false

DaystoImaging
type: Class
comment: Number of days between the date used for index and the date the imaging or scan was performed on the patient. If not applicable please enter 'Not Applicable'
subclass of: FollowUp
is part of: schema.biothings.io
display name: Days to Imaging
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

EvidenceofRecurrenceType
type: Class
comment: The text term used to describe the type of evidence used to determine whether the patient's disease recurred
subclass of: FollowUp
is part of: schema.biothings.io
range includes: BiopsywithHistologicConfirmation
range includes: ConvincingImageSource
range includes: PositiveBiomarkers
display name: Evidence of Recurrence Type
required: sms:false

HAARTTreatmentIndicator
type: Class
comment: The text term used to indicate whether the patient received Highly Active Antiretroviral Therapy (HAART).
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: HAART Treatment Indicator
required: sms:false

HIVViralLoad
type: Class
comment: Numeric value that represents the concentration of an analyte or aliquot extracted from the sample or sample portion, measured in milligrams per milliliter.
subclass of: FollowUp
is part of: schema.biothings.io
display name: HIV Viral Load
required: sms:false

HormonalContraceptiveUse
type: Class
comment: The text term used to indicate whether the patient used hormonal contraceptives.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: CurrentUser
range includes: FormerUser
range includes: NeverUsed
range includes: Unknown
range includes: NotReported
display name: Hormonal Contraceptive Use
required: sms:false

HysterectomyMarginsInvolved
type: Class
comment: The text term used to indicate whether the patient's disease was determined to be involved based on the surgical margins of the hysterectomy.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Bladder
range includes: MacroscopicParametrium
range includes: MicroscopicParametrium
range includes: None
range includes: Vagina
range includes: Unknown
range includes: NotReported
display name: Hysterectomy Margins Involved
required: sms:false

HysterectomyType
type: Class
comment: The text term used to describe the type of hysterectomy the patient had.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: HysterectomyNOS
range includes: Notperformed
range includes: RadicalHysterectomy
range includes: SimpleHysterectomy
range includes: Unknown
range includes: NotReported
display name: Hysterectomy Type
required: sms:false

ImagingResult
type: Class
comment: The text term used to describe the result of the imaging or scan performed on the patient.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Positive
range includes: Indeterminate
range includes: Negative
range includes: NotPerformed
range includes: Unknown
range includes: NotReported
display name: Imaging Result
required: sms:false

ImagingType
type: Class
comment: The text term used to describe the type of imaging or scan performed on the patient.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: 99mTcBoneScintigraphy
range includes: CTScan
range includes: MRI
range includes: PET
display name: Imaging Type
required: sms:false

ImmunosuppressiveTreatmentType
type: Class
comment: The text term used to describe the type of immunosuppresive treatment the patient received.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Anti-TNFTherapy
range includes: Azathioprine
range includes: Cyclophosphamide
range includes: Methotrexate
range includes: None
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Immunosuppressive Treatment Type
required: sms:false

NadirCD4Count
type: Class
comment: Numeric value that represents the lowest point to which the CD4 count has dropped (nadir).
subclass of: FollowUp
is part of: schema.biothings.io
display name: Nadir CD4 Count
required: sms:false

PregnancyOutcome
type: Class
comment: The text term used to describe the type of pregnancy the patient had
subclass of: FollowUp
is part of: schema.biothings.io
range includes: EctopicPregnancy
range includes: InducedAbortion
range includes: LiveBirth
range includes: Miscarriage
range includes: Stillbirth
range includes: Unknown
range includes: NotReported
display name: Pregnancy Outcome
required: sms:false

RecistTargetedRegionsNumber
type: Class
comment: Numeric value that represents the number of baseline target lesions, as described by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria
subclass of: FollowUp
is part of: schema.biothings.io
display name: Recist Targeted Regions Number
required: sms:false

RecistTargetedRegionsSum
type: Class
comment: Numeric value that represents the sum of baseline target lesions, as described by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria.
subclass of: FollowUp
is part of: schema.biothings.io
display name: Recist Targeted Regions Sum
required: sms:false

ScanTracerUsed
type: Class
comment: The text term used to describe the type of tracer used during the imaging or scan of the patient.
subclass of: FollowUp
is part of: schema.biothings.io
range includes: Acetate
range includes: Axumin
range includes: Choline
range includes: PSMA
range includes: SodiumFluoride
display name: Scan Tracer Used
required: sms:false

TreatmentorTherapy
type: Class
comment: A yes/no/unknown/not applicable indicator related to the administration of therapeutic agents received.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Treatment or Therapy
required: sms:false

TreatmentEffect
type: Class
comment: The text term used to describe the pathologic effect a treatment(s) had on the tumor.
subclass of: Therapy
is part of: schema.biothings.io
range includes: CompleteNecrosis(NoViableTumor)
range includes: IncompleteNecrosis(ViableTumorPresent)
range includes: NoNecrosis
range includes: Unknown
range includes: NotReported
display name: Treatment Effect
required: sms:false

TreatmentOutcome
type: Class
comment: Text term that describes the patient's final outcome after the treatment was administered.
subclass of: Therapy
is part of: schema.biothings.io
range includes: CompleteResponse
range includes: MixedResponse
range includes: NoMeasurableDisease
range includes: NoResponse
range includes: PartialResponse
range includes: PersistentDisease
range includes: ProgressiveDisease
range includes: StableDisease
range includes: TreatmentOngoing
range includes: TreatmentStoppedDuetoToxicity
range includes: VeryGoodPartialResponse
range includes: Unknown
range includes: NotReported
display name: Treatment Outcome
required: sms:false

DaystoTreatmentEnd
type: Class
comment: Number of days between the date used for index and the date the treatment ended. If not applicable please enter 'Not Applicable'
subclass of: Therapy
is part of: schema.biothings.io
display name: Days to Treatment End
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

TreatmentAnatomicSite
type: Class
comment: The text term used to describe the anatomic site of resection; biopsy; tissue or organ of biospecimen origin; progression or recurrent disease; treatment
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AbdomenNOS
range includes: Abdominalesophagus
range includes: AccessorysinusNOS
range includes: Acousticnerve
range includes: AdrenalglandNOS
range includes: AmpullaofVater
range includes: Analcanal
range includes: Anterior2/3oftongueNOS
range includes: Anteriorfloorofmouth
range includes: Anteriormediastinum
range includes: Anteriorsurfaceofepiglottis
range includes: Anteriorwallofbladder
range includes: Anteriorwallofnasopharynx
range includes: AnusNOS
range includes: Aorticbodyandotherparaganglia
range includes: Appendix
range includes: Ascendingcolon
range includes: AutonomicnervoussystemNOS
range includes: Axillarytailofbreast
range includes: BaseoftongueNOS
range includes: Bladderneck
range includes: BladderNOS
range includes: Blood
range includes: Bodyofpancreas
range includes: Bodyofpenis
range includes: Bodyofstomach
range includes: Bonemarrow
range includes: BoneoflimbNOS
range includes: BoneNOS
range includes: Bonesofskullandfaceandassociatedjoints
range includes: Borderoftongue
range includes: Brainstem
range includes: BrainNOS
range includes: Branchialcleft
range includes: BreastNOS
range includes: Broadligament
range includes: CardiaNOS
range includes: Carotidbody
range includes: Caudaequina
range includes: Cecum
range includes: Centralportionofbreast
range includes: CerebellumNOS
range includes: Cerebralmeninges
range includes: Cerebrum
range includes: Cervicalesophagus
range includes: Cervixuteri
range includes: Choroid
range includes: Ciliarybody
range includes: Cloacogeniczone
range includes: ColonNOS
range includes: Commissureoflip
range includes: Conjunctiva
range includes: Connectivesubcutaneousandothersofttissuesofabdomen
range includes: Connectivesubcutaneousandothersofttissuesofheadfaceandneck
range includes: Connectivesubcutaneousandothersofttissuesoflowerlimbandhip
range includes: Connectivesubcutaneousandothersofttissuesofpelvis
range includes: Connectivesubcutaneousandothersofttissuesofthorax
range includes: ConnectivesubcutaneousandothersofttissuesoftrunkNOS
range includes: Connectivesubcutaneousandothersofttissuesofupperlimbandshoulder
range includes: ConnectivesubcutaneousandothersofttissuesNOS
range includes: CorneaNOS
range includes: Corpusuteri
range includes: Cortexofadrenalgland
range includes: CranialnerveNOS
range includes: Craniopharyngealduct
range includes: Descendedtestis
range includes: Descendingcolon
range includes: Domeofbladder
range includes: DorsalsurfaceoftongueNOS
range includes: Duodenum
range includes: Endocervix
range includes: EndocrineglandNOS
range includes: Endometrium
range includes: Epididymis
range includes: EsophagusNOS

DaystoTreatmentStart
type: Class
comment: Number of days between the date used for index and the date the treatment started. If not applicable please enter 'Not Applicable'
subclass of: Therapy
is part of: schema.biothings.io
display name: Days to Treatment Start
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

InitialDiseaseStatus
type: Class
comment: The text term used to describe the status of the patient's malignancy when the treatment began.
subclass of: Therapy
is part of: schema.biothings.io
range includes: InitialDiagnosis
range includes: ProgressiveDisease
range includes: RecurrentDisease
range includes: ResidualDisease
range includes: Unknown
range includes: NotReported
display name: Initial Disease Status
required: sms:false

RegimenorLineofTherapy
type: Class
comment: The text term used to describe the regimen or line of therapy.
subclass of: Therapy
is part of: schema.biothings.io
display name: Regimen or Line of Therapy
required: sms:false

TherapeuticAgents
type: Class
comment: Text identification of the individual agent(s) used as part of a treatment regimen.
subclass of: Therapy
is part of: schema.biothings.io
display name: Therapeutic Agents
required: sms:false

TreatmentIntentType
type: Class
comment: Text term to identify the reason for the administration of a treatment regimen. [Manually-curated]
subclass of: Therapy
is part of: schema.biothings.io
range includes: Adjuvant
range includes: CancerControl
range includes: Cure
range includes: Neoadjuvant
range includes: Palliative
range includes: Prevention
range includes: Unknown
range includes: NotReported
display name: Treatment Intent Type
required: sms:false

ChemoConcurrenttoRadiation
type: Class
comment: The text term used to describe whether the patient was receiving chemotherapy concurrent to radiation.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Chemo Concurrent to Radiation
required: sms:false

NumberofCycles
type: Class
comment: The numeric value used to describe the number of cycles of a specific treatment or regimen the patient received.
subclass of: Therapy
is part of: schema.biothings.io
display name: Number of Cycles
required: sms:false

ReasonTreatmentEnded
type: Class
comment: The text term used to describe the reason a specific treatment or regimen ended.
subclass of: Therapy
is part of: schema.biothings.io
range includes: AdverseTherapyEvent
range includes: CourseofTherapyCompleted
range includes: Death
range includes: DiseaseProgression
range includes: Other
range includes: WithdrawalbySubject
display name: Reason Treatment Ended
required: sms:false

TreatmentArm
type: Class
comment: Text term used to describe the treatment arm assigned to a patient at the time eligibility is determined.
subclass of: Therapy
is part of: schema.biothings.io
range includes: A081105
range includes: E4512
range includes: EA5142
display name: Treatment Arm
required: sms:false

TreatmentDose
type: Class
comment: The numeric value used to describe the dose of an agent the patient received.
subclass of: Therapy
is part of: schema.biothings.io
display name: Treatment Dose
required: sms:false

TreatmentDoseUnits
type: Class
comment: The text term used to describe the dose units of an agent the patient received.
subclass of: Therapy
is part of: schema.biothings.io
range includes: CGy
range includes: Gy
display name: Treatment Dose Units
required: sms:false

TreatmentEffectIndicator
type: Class
comment: The text term used to indicate whether the treatment had an effect on the patient.
subclass of: Therapy
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: NotReported
range includes: Unknown
display name: Treatment Effect Indicator
required: sms:false

TreatmentFrequency
type: Class
comment: The text term used to describe the frequency the patient received an agent or regimen.
subclass of: Therapy
is part of: schema.biothings.io
range includes: EveryHour
range includes: FiveTimesDaily
range includes: FourTimesDaily
range includes: ThreeTimesDaily
range includes: TwiceDaily
range includes: Every24Hours
range includes: EveryOtherDay
range includes: TwiceWeekly
range includes: OnceWeekly
range includes: Unknown
range includes: NotReported
display name: Treatment Frequency
required: sms:false

YearofDiagnosis
type: Class
comment: Numeric value to represent the year of an individual's initial pathologic diagnosis of cancer.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Year of Diagnosis
required: sms:false

PrecancerousConditionType
type: Class
comment: The classification of pre-cancerous cells found in a specific collection of data being studied by the Consortium for Molecular and Cellular Characterization of Screen-Detected Lesions (MCL).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: DuctalCarcinomaInSitu
range includes: PancreaticIntraductalPapillary-MucinousNeoplasm
range includes: AtypicalAdenomatousLungHyperplasia
range includes: Other
range includes: PancreaticIntraepithelialNeoplasia
range includes: ProstaticIntraepithelialNeoplasia
range includes: Melanocytichyperplasia
range includes: Atypicalmelanocyticproliferation
range includes: Melanomainsitu
range includes: Superficialspreading
range includes: Lentigomalignatype
range includes: Acral-lentiginous
range includes: Melanomainsituarisinginagiantcongenitalnevus
range includes: Persistentmelanomainsitu
range includes: Melanomainsitunototherwiseclassified
range includes: Scar-noresidualmelanoma
range includes: Invasivemelanoma-superficialspreading
range includes: Invasivemelanoma-nodulartype
range includes: Invasivemelanoma-lentigomaligna
range includes: Invasivemelanoma-acrallentiginous
range includes: Invasivemelanoma-desmoplastic
range includes: Invasivemelanoma-nevoid
range includes: Invasivemelanoma
range includes: NormalWDA
range includes: Reservecellhyperplasia
range includes: Squamousmetaplasia-mature
range includes: Squamousmetaplasia-immature
range includes: Milddysplasia
range includes: Moderatedysplasia
range includes: Severedysplasia
range includes: Atypicaladenomatoushyperplasia
range includes: Adenocarcinomainsitu-nonmucinous
range includes: Adenocarcinomainsitu-mucinous
range includes: BenigntumorNOS
range includes: Hamartoma
range includes: CarcinomaNOS
range includes: Normal
range includes: Squamouscarcinomainsitu
range includes: Neuroendocrinecellhyperplasia
range includes: Nodiagnosispossible
range includes: NotApplicable
display name: Precancerous Condition Type
required: sms:false

MethodofDiagnosis
type: Class
comment: Text term used to describe the method used to confirm the patients malignant diagnosis.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Autopsy
range includes: Biopsy
range includes: BloodDraw
range includes: BoneMarrowAspirate
range includes: CoreBiopsy
range includes: Cytology
range includes: Cystoscopy
range includes: Debulking
range includes: DiagnosticImaging
range includes: DilationandCurettageProcedure
range includes: Enucleation
range includes: ExcisionalBiopsy
range includes: FineNeedleAspiration
range includes: IncisionalBiopsy
range includes: Laparoscopy
range includes: Laparotomy
range includes: Other
range includes: PapSmear
range includes: PhysicalExam
range includes: PathologicReview
range includes: SurgicalResection
range includes: Thoracentesis
range includes: UltrasoundGuidedBiopsy
range includes: Unknown
range includes: NotReported
display name: Method of Diagnosis
required: sms:false

PriorMalignancy
type: Class
comment: The yes/no/unknown indicator used to describe the patient's history of prior cancer diagnosis.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
range includes: NotAllowedToCollect
display name: Prior Malignancy
required: sms:false

PriorTreatment
type: Class
comment: A yes/no/unknown/not applicable indicator related to the administration of therapeutic agents received before the body specimen was collected.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
range includes: NotAllowedToCollect
display name: Prior Treatment
required: sms:false

MetastasisatDiagnosis
type: Class
comment: The text term used to describe the extent of metastatic disease present at diagnosis.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: DistantMetastasis
range includes: MetastasisNOS
range includes: NoMetastasis
range includes: RegionalMetastasis
range includes: Unknown
range includes: NotReported
display name: Metastasis at Diagnosis
required: sms:false

MetastasisatDiagnosisSite
type: Class
comment: Text term to identify an anatomic site in which metastatic disease involvement is found.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Abdomen
range includes: AdrenalGland
range includes: Ascites
range includes: Bone
range includes: BoneMarrow
range includes: Brain
range includes: CerebrospinalFluid
range includes: CentralNervousSystem
range includes: Colon
range includes: DistantNodes
range includes: DistantOrgan
range includes: Groin
range includes: Kidney
range includes: Liver
range includes: Lung
range includes: LymphNode
range includes: Axillary
range includes: Inguinal
range includes: LymphNodeNOS
range includes: Mediastinum
range includes: Omentum
range includes: Ovary
range includes: Pelvis
range includes: PeritonealCavity
range includes: Peritoneum
range includes: Pleura
range includes: Scalp
range includes: Skin
range includes: SmallIntestine
range includes: SoftTissue
range includes: SpinalCord
range includes: Unknown
range includes: NotReported
display name: Metastasis at Diagnosis Site
required: sms:false

FirstSymptomPriortoDiagnosis
type: Class
comment: Text term used to describe the patient's first symptom experienced prior to diagnosis and thought to be related to the disease.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: AlteredMentalStatus
range includes: Headaches
range includes: MotororMovementChanges
range includes: Seizures
range includes: SensoryChanges
range includes: VisualChanges
range includes: Unknown
range includes: NotReported
display name: First Symptom Prior to Diagnosis
required: sms:false

DaystoDiagnosis
type: Class
comment: Number of days between the date used for index and the date the patient was diagnosed with the malignant disease. If not applicable please enter 'Not Applicable'
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Days to Diagnosis
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

PercentTumorInvasion
type: Class
comment: The percentage of tumor cells spread locally in a malignant neoplasm through infiltration or destruction of adjacent tissue.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Percent Tumor Invasion
required: sms:false

ResidualDisease
type: Class
comment: Text terms to describe the status of a tissue margin following surgical resection.
subclass of: Diagnosis
subclass of: InitialDiseaseStatus
is part of: schema.biothings.io
range includes: R0
range includes: R1
range includes: R2
range includes: RX
range includes: Unknown
range includes: NotReported
display name: Residual Disease
required: sms:false

SynchronousMalignancy
type: Class
comment: A yes/no/unknown indicator used to describe whether the patient had an additional malignant diagnosis at the same time the tumor used for sequencing was diagnosed. If both tumors were sequenced, both tumors would have synchronous malignancies.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Synchronous Malignancy
required: sms:false

TumorConfinedtoOrganofOrigin
type: Class
comment: The yes/no/unknown indicator used to describe whether the tumor is confined to the organ where it originated and did not spread to a proximal or distant location within the body.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Tumor Confined to Organ of Origin
required: sms:false

TumorFocality
type: Class
comment: The text term used to describe whether the patient's disease originated in a single location or multiple locations.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Multifocal
range includes: Unifocal
range includes: Unknown
range includes: NotReported
display name: Tumor Focality
required: sms:false

GrossTumorWeight
type: Class
comment: Numeric value used to describe the gross pathologic tumor weight, measured in grams.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Gross Tumor Weight
required: sms:false

BreslowThickness
type: Class
comment: The number that describes the distance, in millimeters, between the upper layer of the epidermis and the deepest point of tumor penetration.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Breslow Thickness
required: sms:false

VascularInvasionPresent
type: Class
comment: The yes/no indicator to ask if large vessel or venous invasion was detected by surgery or presence in a tumor specimen.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes-VascularInvasionPresent
range includes: No
range includes: Unknown
range includes: NotReported
range includes: NotAllowedToCollect
display name: Vascular Invasion Present
required: sms:false

VascularInvasionType
type: Class
comment: Text term that represents the type of vascular tumor invasion.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Extramural
range includes: Intramural
range includes: Macro
range includes: Micro
range includes: NoVascularInvasion
range includes: Unknown
range includes: NotReported
display name: Vascular Invasion Type
required: sms:false

AnaplasiaPresent
type: Class
comment: Yes/no/unknown/Not Reported indicator used to describe whether anaplasia was present at the time of diagnosis.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes-AnaplasiaPresent
range includes: No
range includes: Unknown
range includes: NotReported
display name: Anaplasia Present
required: sms:false

AnaplasiaPresentType
type: Class
comment: The text term used to describe the morphologic findings indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Absent
range includes: Diffuse
range includes: Equivocal
range includes: Focal
range includes: Present
range includes: Sclerosis
range includes: Unknown
range includes: NotReported
display name: Anaplasia Present Type
required: sms:false

Laterality
type: Class
comment: For tumors in paired organs, designates the side on which the cancer originates.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Bilateral
range includes: Left
range includes: Midline
range includes: Right
range includes: Unilateral
range includes: Unknown
range includes: NotReported
display name: Laterality
required: sms:false

PerineuralInvasionPresent
type: Class
comment: A yes/no indicator to ask if perineural invasion or infiltration of tumor or cancer is present.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Perineural Invasion Present
required: sms:false

LymphaticInvasionPresent
type: Class
comment: A yes/no indicator to ask if small or thin-walled vessel invasion is present, indicating lymphatic involvement
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Lymphatic Invasion Present
required: sms:false

LymphNodesPositive
type: Class
comment: The number of lymph nodes involved with disease as determined by pathologic examination.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Lymph Nodes Positive
required: sms:false

LymphNodesTested
type: Class
comment: The number of lymph nodes tested to determine whether lymph nodes were involved with disease as determined by a pathologic examination.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Lymph Nodes Tested
required: sms:false

PeritonealFluidCytologicalStatus
type: Class
comment: The text term used to describe the malignant status of the peritoneal fluid determined by cytologic testing.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Atypical
range includes: Malignant
range includes: Non-Malignant
range includes: Unsatisfactory
range includes: Unknown
range includes: NotReported
display name: Peritoneal Fluid Cytological Status
required: sms:false

ClassificationofTumor
type: Class
comment: Text that describes the kind of disease present in the tumor specimen as related to a specific timepoint.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Primary
range includes: Metastasis
range includes: Recurrence
range includes: Other
range includes: Unknown
range includes: NotReported
range includes: NotAllowedToCollect
display name: Classification of Tumor
required: sms:false

BestOverallResponse
type: Class
comment: The best improvement achieved throughout the entire course of protocol treatment.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: AJ-AdjuvantTherapy
range includes: CPD-ClinicalProgression
range includes: CR-CompleteResponse
range includes: CRU-CompleteResponseUnconfirmed
range includes: DU-DiseaseUnchanged
range includes: IMR-Immunoresponse
range includes: IPD-Immunoprogression
range includes: MarginalResponse
range includes: MX-MixedResponse
range includes: Non-CR/Non-PD-Non-CR/Non-PD
range includes: NPB-NoPalliativeBenefit
range includes: NR-NoResponse
range includes: PA-PalliativeTherapy
range includes: PB-PalliativeBenefit
range includes: PD-ProgressiveDisease
range includes: PPD-Pseudoprogression
range includes: PR-PartialResponse
range includes: PSR-Pseudoresponse
range includes: RD-ResponsiveDisease
range includes: RP-Response
range includes: RPD-RadiographicProgressiveDisease
range includes: SCR-StringentCompleteResponse
range includes: SD-StableDisease
range includes: SPD-SurgicalProgression
range includes: TE-TooEarly
range includes: VGPR-VeryGoodPartialResponse
display name: Best Overall Response
required: sms:false

MitoticCount
type: Class
comment: The number of mitoses identified under the microscope in tumors. The method of counting varies, according to the specific tumor examined. Usually, the mitotic count is determined based on the number of mitoses per high power field (40X) or 10 high power fields.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Mitotic Count
required: sms:false

AJCCClinicalM
type: Class
comment: Extent of the distant metastasis for the cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: M0
range includes: M1
range includes: M1a
range includes: M1b
range includes: M1c
range includes: MX
range includes: CM0(i+)
range includes: Unknown
range includes: NotReported
display name: AJCC Clinical M
required: sms:false

AJCCClinicalN
type: Class
comment: Extent of the regional lymph node involvement for the cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: N0
range includes: N0(i+)
range includes: N0(i-)
range includes: N0(mol+)
range includes: N0(mol-)
range includes: N1
range includes: N1a
range includes: N1b
range includes: N1bI
range includes: N1bII
range includes: N1bIII
range includes: N1bIV
range includes: N1c
range includes: N1mi
range includes: N2
range includes: N2a
range includes: N2b
range includes: N2c
range includes: N3
range includes: N3a
range includes: N3b
range includes: N3c
range includes: N4
range includes: NX
range includes: Unknown
range includes: NotReported
display name: AJCC Clinical N
required: sms:false

AJCCClinicalStage
type: Class
comment: Stage group determined from clinical information on the tumor (T), regional node (N) and metastases (M) and by grouping cases with similar prognosis for cancer.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Stage0
range includes: Stage0a
range includes: Stage0is
range includes: StageI
range includes: StageIA
range includes: StageIA1
range includes: StageIA2
range includes: StageIB
range includes: StageIB1
range includes: StageIB2
range includes: StageIC
range includes: StageII
range includes: StageIIA
range includes: StageIIA1
range includes: StageIIA2
range includes: StageIIB
range includes: StageIIC
range includes: StageIIC1
range includes: StageIII
range includes: StageIIIA
range includes: StageIIIB
range includes: StageIIIC
range includes: StageIIIC1
range includes: StageIIIC2
range includes: StageIS
range includes: StageIV
range includes: StageIVA
range includes: StageIVB
range includes: StageIVC
range includes: StageTis
range includes: StageX
range includes: Unknown
range includes: NotReported
display name: AJCC Clinical Stage
required: sms:false

AJCCClinicalT
type: Class
comment: Extent of the primary cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: T0
range includes: T1
range includes: T1a
range includes: T1a1
range includes: T1a2
range includes: T1b
range includes: T1b1
range includes: T1b2
range includes: T1c
range includes: T1mi
range includes: T2
range includes: T2a
range includes: T2a1
range includes: T2a2
range includes: T2b
range includes: T2c
range includes: T2d
range includes: T3
range includes: T3a
range includes: T3b
range includes: T3c
range includes: T3d
range includes: T4
range includes: T4a
range includes: T4b
range includes: T4c
range includes: T4d
range includes: T4e
range includes: TX
range includes: Ta
range includes: Tis
range includes: Tis(DCIS)
range includes: Tis(LCIS)
range includes: Tis(Paget's)
range includes: Unknown
range includes: NotReported
display name: AJCC Clinical T
required: sms:false

AJCCPathologicM
type: Class
comment: Code to represent the defined absence or presence of distant spread or metastases (M) to locations via vascular channels or lymphatics beyond the regional lymph nodes, using criteria established by the American Joint Committee on Cancer (AJCC).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: M0
range includes: M1
range includes: M1a
range includes: M1b
range includes: M1c
range includes: MX
range includes: CM0(i+)
range includes: Unknown
range includes: NotReported
display name: AJCC Pathologic M
required: sms:false

AJCCPathologicN
type: Class
comment: The codes that represent the stage of cancer based on the nodes present (N stage) according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: N0
range includes: N0(i+)
range includes: N0(i-)
range includes: N0(mol+)
range includes: N0(mol-)
range includes: N1
range includes: N1a
range includes: N1b
range includes: N1bI
range includes: N1bII
range includes: N1bIII
range includes: N1bIV
range includes: N1c
range includes: N1mi
range includes: N2
range includes: N2a
range includes: N2b
range includes: N2c
range includes: N3
range includes: N3a
range includes: N3b
range includes: N3c
range includes: N4
range includes: NX
range includes: Unknown
range includes: NotReported
display name: AJCC Pathologic N
required: sms:false

AJCCPathologicStage
type: Class
comment: The extent of a cancer, especially whether the disease has spread from the original site to other parts of the body based on AJCC staging criteria.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Stage0
range includes: Stage0a
range includes: Stage0is
range includes: StageI
range includes: StageIA
range includes: StageIA1
range includes: StageIA2
range includes: StageIB
range includes: StageIB1
range includes: StageIB2
range includes: StageIC
range includes: StageII
range includes: StageIIA
range includes: StageIIA1
range includes: StageIIA2
range includes: StageIIB
range includes: StageIIC
range includes: StageIIC1
range includes: StageIII
range includes: StageIIIA
range includes: StageIIIB
range includes: StageIIIC
range includes: StageIIIC1
range includes: StageIIIC2
range includes: StageIS
range includes: StageIV
range includes: StageIVA
range includes: StageIVB
range includes: StageIVC
range includes: StageTis
range includes: StageX
range includes: Unknown
range includes: NotReported
display name: AJCC Pathologic Stage
required: sms:false

AJCCPathologicT
type: Class
comment: Code of pathological T (primary tumor) to define the size or contiguous extension of the primary tumor (T), using staging criteria from the American Joint Committee on Cancer (AJCC).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: T0
range includes: T1
range includes: T1a
range includes: T1a1
range includes: T1a2
range includes: T1b
range includes: T1b1
range includes: T1b2
range includes: T1c
range includes: T1mi
range includes: T2
range includes: T2a
range includes: T2a1
range includes: T2a2
range includes: T2b
range includes: T2c
range includes: T2d
range includes: T3
range includes: T3a
range includes: T3b
range includes: T3c
range includes: T3d
range includes: T4
range includes: T4a
range includes: T4b
range includes: T4c
range includes: T4d
range includes: T4e
range includes: TX
range includes: Ta
range includes: Tis
range includes: Tis(DCIS)
range includes: Tis(LCIS)
range includes: Tis(Paget's)
range includes: Unknown
range includes: NotReported
display name: AJCC Pathologic T
required: sms:false

AJCCStagingSystemEdition
type: Class
comment: The text term used to describe the version or edition of the American Joint Committee on Cancer Staging Handbooks, a publication by the group formed for the purpose of developing a system of staging for cancer that is acceptable to the American medical profession and is compatible with other accepted classifications.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: 1st
range includes: 2nd
range includes: 3rd
range includes: 4th
range includes: 5th
range includes: 6th
range includes: 7th
range includes: 8th
range includes: Unknown
range includes: NotReported
display name: AJCC Staging System Edition
required: sms:false

CogNeuroblastomaRiskGroup
type: Class
comment: Text term that represents the categorization of patients on the basis of prognostic factors per a system developed by Children's Oncology Group (COG). Risk level is used to assign treatment intensity.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: HighRisk
range includes: IntermediateRisk
range includes: LowRisk
range includes: Unknown
range includes: NotReported
display name: Cog Neuroblastoma Risk Group
required: sms:false

CogRhabdomyosarcomaRiskGroup
type: Class
comment: Text term used to describe the classification of rhabdomyosarcoma, as defined by the Children's Oncology Group (COG).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: HighRisk
range includes: IntermediateRisk
range includes: LowRisk
range includes: Unknown
range includes: NotReported
display name: Cog Rhabdomyosarcoma Risk Group
required: sms:false

GleasonGradeGroup
type: Class
comment: The text term used to describe the overall grouping of grades defined by the Gleason grading classification, which is used to determine the aggressiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Group1
range includes: Group2
range includes: Group3
range includes: Group4
range includes: Group5
display name: Gleason Grade Group
required: sms:false

GleasonGradeTertiary
type: Class
comment: The text term used to describe the tertiary pattern as described by the Gleason Grading System.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Pattern4
range includes: Pattern5
display name: Gleason Grade Tertiary
required: sms:false

GleasonPatternsPercent
type: Class
comment: Numeric value that represents the percentage of Patterns 4 and 5, which is used when the Gleason score is greater than 7 to predict prognosis.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Gleason Patterns Percent
required: sms:false

GreatestTumorDimension
type: Class
comment: Numeric value that represents the measurement of the widest portion of the tumor in centimeters.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Greatest Tumor Dimension
required: sms:false

IGCCCGStage
type: Class
comment: The text term used to describe the International Germ Cell Cancer Collaborative Group (IGCCCG), a grouping used to further classify metastatic testicular tumors.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: GoodPrognosis
range includes: IntermediatePrognosis
range includes: PoorPrognosis
range includes: Unknown
range includes: NotReported
display name: IGCCCG Stage
required: sms:false

INPCGrade
type: Class
comment: Text term used to describe the classification of neuroblastic differentiation within neuroblastoma tumors, as defined by the International Neuroblastoma Pathology Classification (INPC).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Differentiating
range includes: PoorlyDifferentiated
range includes: Undifferentiated
range includes: Unknown
range includes: NotReported
display name: INPC Grade
required: sms:false

INPCHistologicGroup
type: Class
comment: The text term used to describe the classification of neuroblastomas distinguishing between favorable and unfavorable histologic groups. The histologic score, defined by the International Neuroblastoma Pathology Classification (INPC), is based on age, mitosis-karyorrhexis index (MKI), stromal content and degree of tumor cell differentiation.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Favorable
range includes: Unfavorable
range includes: Unknown
range includes: NotReported
display name: INPC Histologic Group
required: sms:false

INRGStage
type: Class
comment: The text term used to describe the staging classification of neuroblastic tumors, as defined by the International Neuroblastoma Risk Group (INRG).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: L1
range includes: L2
range includes: M
range includes: Ms
range includes: Unknown
range includes: NotReported
display name: INRG Stage
required: sms:false

INSSStage
type: Class
comment: Text term used to describe the staging classification of neuroblastic tumors, as defined by the International Neuroblastoma Staging System (INSS).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Stage1
range includes: Stage2A
range includes: Stage2B
range includes: Stage3
range includes: Stage4
range includes: Stage4S
range includes: Unknown
range includes: NotReported
display name: INSS Stage
required: sms:false

InternationalPrognosticIndex
type: Class
comment: The text term used to describe the International Prognostic Index, which classifies the prognosis of patients with aggressive non-Hodgkin's lymphoma.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: LowRisk
range includes: Low-IntermediateRisk
range includes: High-IntermediateRisk
range includes: HighRisk
display name: International Prognostic Index
required: sms:false

IRSGroup
type: Class
comment: Text term used to describe the classification of rhabdomyosarcoma tumors, as defined by the Intergroup Rhabdomyosarcoma Study (IRS).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: GroupI
range includes: GroupIa
range includes: GroupIb
range includes: GroupII
range includes: GroupIIa
range includes: GroupIIc
range includes: GroupIII
range includes: GroupIIIa
range includes: GroupIIIb
range includes: GroupIV
range includes: Unknown
range includes: NotReported
display name: IRS Group
required: sms:false

IRSStage
type: Class
comment: The text term used to describe the classification of rhabdomyosarcoma tumors, as defined by the Intergroup Rhabdomyosarcoma Study (IRS).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: 1
range includes: 2
range includes: 3
range includes: 4
range includes: Unknown
range includes: NotReported
display name: IRS Stage
required: sms:false

ISSStage
type: Class
comment: The multiple myeloma disease stage at diagnosis.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: I
range includes: II
range includes: III
range includes: NotReported
range includes: Unknown
display name: ISS Stage
required: sms:false

LymphNodeInvolvedSite
type: Class
comment: The text term used to describe the anatomic site of lymph node involvement.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Axillary
range includes: Cervical
range includes: Epitrochlear
range includes: Femoral
range includes: Hilar
range includes: Iliac-common
range includes: Iliac-external
range includes: Iliac
range includes: NOS
range includes: Inguinal
range includes: Mediastinal
range includes: Mesenteric
range includes: None
range includes: Occipital
range includes: Paraaortic
range includes: Parotid
range includes: Popliteal
range includes: Retroperitoneal
range includes: Splenic
range includes: Submandibular
range includes: Supraclavicular
range includes: Unknown
range includes: NotReported
display name: Lymph Node Involved Site
required: sms:false

MarginDistance
type: Class
comment: Numeric value (in centimeters) that represents the distance between the tumor and the surgical margin.
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Margin Distance
required: sms:false

MarginsInvolvedSite
type: Class
comment: The text term used to describe the anatomic sites that were involved in the survival margins.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: GerotaFascia
range includes: Parenchyma
range includes: PerinephricFat
range includes: Renal
range includes: RenalCapsule
range includes: RenalSinus
range includes: RenalVein
range includes: Ureter
display name: Margins Involved Site
required: sms:false

MedulloblastomaMolecularClassification
type: Class
comment: The text term used to describe the classification of medulloblastoma tumors based on molecular features.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: NotDetermined
range includes: Non-WNT/non-SHHActivated
range includes: SHH-Activated
range includes: WNT-Activated
range includes: Unknown
range includes: NotReported
display name: Medulloblastoma Molecular Classification
required: sms:false

MicropapillaryFeatures
type: Class
comment: The yes/no/unknown indicator used to describe whether micropapillary features were determined to be present.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Absent
range includes: Present
range includes: Unknown
range includes: NotReported
display name: Micropapillary Features
required: sms:false

MitosisKaryorrhexisIndex
type: Class
comment: Text term that represents the component of the International Neuroblastoma Pathology Classification (INPC) for mitosis-karyorrhexis index (MKI).
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: High
range includes: Intermediate
range includes: Low
range includes: Unknown
range includes: NotReported
display name: Mitosis Karyorrhexis Index
required: sms:false

NonNodalRegionalDisease
type: Class
comment: The text term used to describe whether the patient had non-nodal regional disease.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Absent
range includes: Indeterminate
range includes: Present
range includes: Unknown
range includes: NotReported
display name: Non Nodal Regional Disease
required: sms:false

NonNodalTumorDeposits
type: Class
comment: The yes/no/unknown indicator used to describe the presence of tumor deposits in the pericolic or perirectal fat or in adjacent mesentery away from the leading edge of the tumor.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Non Nodal Tumor Deposits
required: sms:false

OvarianSpecimenStatus
type: Class
comment: The text term used to describe the physical condition of the involved ovary.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: OvarianCapsuleIntact
range includes: OvarianCapsuleRuptured
range includes: OvarianCapsuleFragmented
range includes: Unknown
range includes: NotReported
display name: Ovarian Specimen Status
required: sms:false

OvarianSurfaceInvolvement
type: Class
comment: The text term that describes whether the surface tissue (outer boundary) of the ovary shows evidence of involvement or presence of cancer.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Absent
range includes: Present
range includes: Indeterminate
range includes: Unknown
range includes: NotReported
display name: Ovarian Surface Involvement
required: sms:false

PregnantatDiagnosis
type: Class
comment: The text term used to indicate whether the patient was pregnant at the time they were diagnosed.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Pregnant at Diagnosis
required: sms:false

PrimaryGleasonGrade
type: Class
comment: The text term used to describe the primary Gleason score, which describes the pattern of cells making up the largest area of the tumor. The primary and secondary Gleason pattern grades are combined to determine the patient's Gleason grade group, which is used to determine the aggresiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Pattern1
range includes: Pattern2
range includes: Pattern3
range includes: Pattern4
range includes: Pattern5
display name: Primary Gleason Grade
required: sms:false

SecondaryGleasonGrade
type: Class
comment: The text term used to describe the secondary Gleason score, which describes the pattern of cells making up the second largest area of the tumor. The primary and secondary Gleason pattern grades are combined to determine the patient's Gleason grade group, which is used to determine the aggresiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Pattern1
range includes: Pattern2
range includes: Pattern3
range includes: Pattern4
range includes: Pattern5
display name: Secondary Gleason Grade
required: sms:false

SupratentorialLocalization
type: Class
comment: Text term to specify the location of the supratentorial tumor.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: CerebralCortex
range includes: DeepGray
range includes: SpinalCord
range includes: WhiteMatter
range includes: Unknown
range includes: NotReported
display name: Supratentorial Localization
required: sms:false

TumorDepth
type: Class
comment: Numeric value that represents the depth of tumor invasion, measured in millimeters (mm).
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Tumor Depth
required: sms:false

WHOCNSGrade
type: Class
comment: WHO CNS Grade
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: GradeI
range includes: GradeII
range includes: GradeIII
range includes: GradeIV
range includes: GradeNotAssigned
range includes: Unknown
range includes: NotReported
display name: WHO CNS Grade
required: sms:false

WHONTEGrade
type: Class
comment: WHO NTE Grade
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: G1
range includes: G2
range includes: G3
range includes: GX
range includes: Unknown
range includes: NotReported
display name: WHO NTE Grade
required: sms:false

AAChange
type: Class
comment: Alphanumeric value used to describe the amino acid change for a specific genetic variant. Example: R116Q. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: AA Change
required: sms:false

Antigen
type: Class
comment: The text term used to describe an antigen included in molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: BCL6
range includes: CA-125
range includes: CA19-9
range includes: CCND1
range includes: CD10
range includes: CD117
range includes: CD138
range includes: CD14
range includes: CD15
range includes: CD19
range includes: CD20
range includes: CD22
range includes: CD23
range includes: CD25
range includes: CD3
range includes: CD30
range includes: CD33
range includes: CD34
range includes: CD45
range includes: CD5
range includes: CD56
range includes: CD7
range includes: CD79A
range includes: CEA
range includes: HLA-DR
range includes: Mesothelin
range includes: NSE
range includes: SquamousCellCarcinomaAntigen
range includes: Unknown
range includes: NotReported
display name: Antigen
required: sms:false

ClinicalBiospecimenType
type: Class
comment: The text term used to describe the biological material used for testing, diagnostic, treatment or research purposes. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Blood
range includes: BoneMarrow
range includes: BuccalMucosa
range includes: BuffyCoat
range includes: CerebrospinalFluid
range includes: ConnectiveTissue
range includes: EmbryonicFluid
range includes: EmbryonicTissue
range includes: Feces
range includes: Granulocyte
range includes: MuscleTissue
range includes: NerveTissue
range includes: PeritonealFluid
range includes: Plasma
range includes: PleuralFluid
range includes: Saliva
range includes: Serum
range includes: Skin
range includes: SoftTissue
range includes: TissueNOS
range includes: UninvolvedTissueNOS
range includes: Urine
range includes: Unknown
range includes: NotReported
display name: Clinical Biospecimen Type
required: sms:false

BloodTestNormalRangeUpper
type: Class
comment: Numeric value used to describe the upper limit of the normal range used to describe a healthy individual at the institution where the test was completed.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Blood Test Normal Range Upper
required: sms:false

BloodTestNormalRangeLower
type: Class
comment: Numeric value used to describe the lower limit of the normal range used to describe a healthy individual at the institution where the test was completed.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Blood Test Normal Range Lower
required: sms:false

CellCount
type: Class
comment: Numeric value used to describe the number of cells used for molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Cell Count
required: sms:false

Chromosome
type: Class
comment: The text term used to describe a chromosome targeted or included in molecular testing. If a specific genetic variant is being reported, this property can be used to capture the chromosome where that variant is located. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Chr1
range includes: Chr2
range includes: Chr3
range includes: Chr4
range includes: Chr5
range includes: Chr6
range includes: Chr7
range includes: Chr8
range includes: Chr9
range includes: Chr10
range includes: Chr11
range includes: Chr12
range includes: Chr13
range includes: Chr14
range includes: Chr15
range includes: Chr16
range includes: Chr17
range includes: Chr18
range includes: Chr19
range includes: Chr20
range includes: Chr21
range includes: Chr22
range includes: Chr23
range includes: ChrM
range includes: ChrX
range includes: ChrY
range includes: Unknown
range includes: NotReported
display name: Chromosome
required: sms:false

Clonality
type: Class
comment: The text term used to describe whether a genomic variant is related by descent from a single progenitor cell. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Clonal
range includes: Non-clonal
display name: Clonality
required: sms:false

CopyNumber
type: Class
comment: Numeric value used to describe the number of times a section of the genome is repeated or copied within an insertion, duplication or deletion variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Copy Number
required: sms:false

Cytoband
type: Class
comment: Alphanumeric value used to describe the cytoband or chromosomal location targeted or included in molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the cytoband where the variant is located. Format: [chromosome][chromosome arm].[band+sub-bands]. Example: 17p13.1. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Cytoband
required: sms:false

Exon
type: Class
comment: Exon number targeted or included in a molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the exon where that variant is located. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Exon
required: sms:false

HistoneFamily
type: Class
comment: The text term used to describe the family, or classification of a group of basic proteins found in chromatin, called histones.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: H1
range includes: H2A
range includes: H2B
range includes: H3
range includes: H4
range includes: Unknown
range includes: NotReported
display name: Histone Family
required: sms:false

HistoneVariant
type: Class
comment: The text term used to describe a specific histone variants, which are proteins that substitute for the core canonical histones.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: CENP-A
range includes: H2A-Bbd
range includes: H2A.X
range includes: H2A.Z
range includes: H2A.Z.1
range includes: H2A.Z.2
range includes: H2A.Z.2.2
range includes: H3.1
range includes: H3.2
range includes: H3.3
range includes: H3.5
range includes: H3.X
range includes: H3.Y
range includes: H3t(H3.4)
range includes: MH2A
range includes: MH2A.1
range includes: MH2A.2
range includes: Unknown
range includes: NotReported
display name: Histone Variant
required: sms:false

Intron
type: Class
comment: Intron number targeted or included in molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the intron where that variant is located.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Intron
required: sms:false

LaboratoryTest
type: Class
comment: The text term used to describe the medical testing used to diagnose, treat or further understand a patient's disease.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: AbsoluteNeutrophil
range includes: Albumin
range includes: AlphaFetoprotein
range includes: B-cellgenotyping
range includes: Basophil
range includes: Beta2Microglobulin
range includes: BloodUreaNitrogen
range includes: C-ReactiveProtein
range includes: Calcium
range includes: Cellularity
range includes: CirculatingTumorCells
range includes: Creatinine
range includes: Eosinophil
range includes: Epstein-BarrVirus
range includes: Glucose
range includes: Hematocrit
range includes: Hemoglobin
range includes: HPV-E6/E7
range includes: HumanChorionicGonadotropin
range includes: HumanPapillomavirus
range includes: ImmunoglobulinA
range includes: ImmunoglobulinG
range includes: ImmunoglobulinM
range includes: LactateDehydrogenase
range includes: Leukocytes
range includes: LuteinizingHormone
range includes: Lymphoblasts
range includes: Lymphocytes
range includes: MProtein
range includes: Metamyelocytes
range includes: Myeloblasts
range includes: Myelocytes
range includes: NeutrophilBands
range includes: Platelets
range includes: Prolymphocytes
range includes: Promonocytes
range includes: Promyelocytes
range includes: SegmentedNeutrophil
range includes: SerumFreeImmunoglobulinLightChain
range includes: Kappa
range includes: Lambda
range includes: NOS
range includes: Testosterone
range includes: TotalBilirubin
range includes: TotalProtein
range includes: Unknown
range includes: NotReported
display name: Laboratory Test
required: sms:false

LociAbnormalCount
type: Class
comment: Numeric value used to describe the number of loci determined to be abnormal.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Loci Abnormal Count
required: sms:false

LociCount
type: Class
comment: Numeric value used to describe the number of loci tested.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Loci Count
required: sms:false

Locus
type: Class
comment: Alphanumeric value used to describe the locus of a specific genetic variant. Example: NM_001126114.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Locus
required: sms:false

MismatchRepairMutation
type: Class
comment: The yes/no/unknown indicator used to describe whether the mutation included in molecular testing was known to have an affect on the mismatch repair process. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Mismatch Repair Mutation
required: sms:false

MolecularConsequence
type: Class
comment: The text term used to describe the molecular consequence of genetic variation. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: 3PrimeUTRVariant
range includes: 5PrimeUTRVariant
range includes: CodingSequenceVariant
range includes: DownstreamGeneVariant
range includes: FeatureElongation
range includes: FeatureTruncation
range includes: FrameshiftVariant
range includes: IncompleteTerminalCodonVariant
range includes: InframeDeletion
range includes: InframeInsertion
range includes: IntergenicVariant
range includes: IntronVariant
range includes: MaturemiRNAVariant
range includes: MissenseVariant
range includes: NMDTranscriptVariant
range includes: Non-codingTranscriptExonVariant
range includes: Non-codingTranscriptVariant
range includes: ProteinAlteringVariant
range includes: RegulatoryRegionAblation
range includes: RegulatoryRegionAmplification
range includes: RegulatoryRegionVariant
range includes: SpliceAcceptorVariant
range includes: SpliceDonorVariant
range includes: SpliceRegionVariant
range includes: StartLost
range includes: StopGain
range includes: StopLost
range includes: StopRetainedVariant
range includes: SynonymousVariant
range includes: TFBindingSiteVariant
range includes: TFBSAblation
range includes: TFBSAmplification
range includes: TranscriptAblation
range includes: TranscriptAmplification
range includes: UpstreamGeneVariant
display name: Molecular Consequence
required: sms:false

Pathogenicity
type: Class
comment: The text used to describe a variant's level of involvement in the cause of the patient's disease according to the standards outlined by the American College of Medical Genetics and Genomics (ACMG).
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Benign
range includes: LikelyBenign
range includes: LikelyPathogenic
range includes: Pathogenic
range includes: UncertainSignificance
display name: Pathogenicity
required: sms:false

Ploidy
type: Class
comment: Text term used to describe the number of sets of homologous chromosomes.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Aneuploid
range includes: Diploid
range includes: Hyperdiploid
range includes: Hypodiploid
range includes: NearDiploid
range includes: Tetraploid
range includes: Unknown
range includes: NotReported
display name: Ploidy
required: sms:false

SecondExon
type: Class
comment: The second exon number involved in molecular variation. If a specific genetic variant is being reported, this property can be used to capture the second exon where that variant is located. This property is typically used for a translocation where two different locations are involved in the variation.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Second Exon
required: sms:false

SecondGeneSymbol
type: Class
comment: The text term used to describe a secondary gene targeted or included in molecular analysis. For rearrangements, this is should represent the location of the variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Second Gene Symbol
required: sms:false

SpecializedMolecularTest
type: Class
comment: Text term used to describe a specific test that is not covered in the list of molecular analysis methods. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Specialized Molecular Test
required: sms:false

TestAnalyteType
type: Class
comment: The text term used to describe the type of analyte used for molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: DNA
range includes: MRNA
range includes: MiRNA
range includes: ProteinAnalyte
range includes: TotalRNA
range includes: Unknown
range includes: NotReported
display name: Test Analyte Type
required: sms:false

TestUnits
type: Class
comment: The text term used to describe the units of the test value for a molecular test. This property is used in conjunction with test_value. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Test Units
required: sms:false

TestValue
type: Class
comment: The text term or numeric value used to describe a specific result of a molecular test. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Test Value
required: sms:false

Transcript
type: Class
comment: Alphanumeric value used to describe the transcript of a specific genetic variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
display name: Transcript
required: sms:false

VariantOrigin
type: Class
comment: The text term used to describe the biological origin of a specific genetic variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Germline
range includes: Somatic
range includes: Unknown
display name: Variant Origin
required: sms:false

VariantType
type: Class
comment: The text term used to describe the type of genetic variation.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Alleles
range includes: Amplification
range includes: Chrimerism
range includes: Conversion
range includes: Deletion
range includes: Deletion-Insertion
range includes: Duplication
range includes: Extension
range includes: Gain
range includes: Hypermethylation
range includes: Insertion
range includes: Inversion
range includes: Loss
range includes: Methylation
range includes: Mosaicism
range includes: Other
range includes: PartialMethylation
range includes: Rearrangement
range includes: RepeatedSequences
range includes: Splice
range includes: Substitution
range includes: Translocation
range includes: Unknown
range includes: NotReported
display name: Variant Type
required: sms:false

Zygosity
type: Class
comment: The text term used to describe the zygosity of a specific genetic variant.
subclass of: MolecularTest
is part of: schema.biothings.io
range includes: Heterozygous
range includes: Hemizygous
range includes: Homozygous
range includes: Nullizygous
range includes: Unknown
range includes: NotReported
display name: Zygosity
required: sms:false

SourceHTANBiospecimenID
type: Class
comment: This is the HTAN ID that may have been assigned to the biospecimen at the site of biospecimen origin (e.g. BU).
subclass of: Biosample
is part of: schema.biothings.io
display name: Source HTAN Biospecimen ID
required: sms:false

CollectionDaysfromIndex
type: Class
comment: Number of days from the research participant's index date that the biospecimen was obtained. If not applicable please enter 'Not Applicable'
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Collection Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

AdjacentBiospecimenIDs
type: Class
comment: List of HTAN Identifiers (separated by commas) of adjacent biospecimens cut from the same sample; for example HTA3_3000_3, HTA3_3000_4, ...
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Adjacent Biospecimen IDs
required: sms:false

BiospecimenType
type: Class
comment: Biospecimen Type
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: TissueBiospecimenType
range includes: BloodBiospecimenType
range includes: AnalyteBiospecimenType
range includes: MouthRinseBiospecimenType
range includes: StoolBiospecimenType
range includes: UrineBiospecimenType
range includes: AscitesBiospecimenType
range includes: SputumBiospecimenType
range includes: FluidsBiospecimenType
range includes: BoneMarrowBiospecimenType
range includes: CellsBiospecimenType
display name: Biospecimen Type
required: sms:true

AcquisitionMethodType
type: Class
comment: Records the method of acquisition or source for the specimen under consideration.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Autopsy
range includes: Biopsy
range includes: FineNeedleAspirate
range includes: SurgicalResection
range includes: PunchBiopsy
range includes: ShaveBiopsy
range includes: Excision
range includes: Re-excision
range includes: SentinelNodeBiopsy
range includes: Lymphadenectomy-RegionalNodes
range includes: OtherAcquisitionMethod
range includes: Noninducedsputum
range includes: Inducedsputum
range includes: BAL(bronchialalveolarlavage)
range includes: Cytobrush
range includes: Blooddraw
range includes: Fluidcollection
range includes: Forcepsbiopsy
range includes: Coreneedlebiopsy
range includes: Endoscopicbiopsy
range includes: Notspecified
display name: Acquisition Method Type
required: sms:true

FixativeType
type: Class
comment: Text term to identify the type of fixative used to preserve a tissue specimen
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Acetone
range includes: Alcohol
range includes: Formalin
range includes: Glutaraldehyde
range includes: OCTmedia
range includes: RNAlater
range includes: Saline
range includes: 95%Ethanol
range includes: Dimidoester
range includes: Carbodiimide
range includes: Dimethylacetamide
range includes: Para-benzoquinone
range includes: PAXgenetissue
range includes: TCLlysisbuffer
range includes: NP40lysisbuffer
range includes: Methacarn
range includes: Cryo-store
range includes: Carnoy'sFixative
range includes: Polaxamer
range includes: Other
range includes: None
range includes: Unknown
range includes: Unfixed
display name: Fixative Type
required: sms:true

StorageMethod
type: Class
comment: The method by which a biomaterial was stored after preservation or before another protocol was used.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Ambienttemperature
range includes: Cutslide
range includes: Fresh
range includes: Frozenat-20C
range includes: Frozenat-70C
range includes: Frozenat-80C
range includes: Frozenat-150C
range includes: Frozeninliquidnitrogen
range includes: Frozeninvaporphase
range includes: Paraffinblock
range includes: RNAlaterat4C
range includes: RNAlaterat25C
range includes: RNAlaterat-20C
range includes: Refrigeratedat4degrees
range includes: Refrigeratedvacuumchamber
range includes: 4Cinvacuumchamber
range includes: Desiccantat4C
range includes: NotApplicable
range includes: Unknown
display name: Storage Method
required: sms:true

ProcessingDaysfromIndex
type: Class
comment: Number of days from the research participant's index date that the biospecimen was processed. If not applicable please enter 'Not Applicable'
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Processing Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

ProtocolLink
type: Class
comment: Protocols.io ID or DOI link to a free/open protocol resource describing in detail the assay protocol (e.g. surface markers used in Smart-seq, dissociation duration, lot/batch numbers for key reagents such as primers, sequencing reagent kits, etc.) or the protocol by which the sample was obtained or generated.
subclass of: InformationContentEntity
is part of: schema.biothings.io
display name: Protocol Link
required: sms:true

SiteDataSource
type: Class
comment: Text to identify the data source for the specimen/sample from within the HTAN center, if applicable. Any identifier used within the center to identify data sources. No PHI/PII is allowed.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Site Data Source
required: sms:false

CollectionMedia
type: Class
comment: Material Specimen is collected into post procedure
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: DMEM
range includes: DMEM+Serum
range includes: RPMI
range includes: RPMI+Serum
range includes: PBS
range includes: PBS+Serum
range includes: None
display name: Collection Media
required: sms:false

MountingMedium
type: Class
comment: The solution in which the specimen is embedded, generally under a cover glass. It may be liquid, gum or resinous, soluble in water, alcohol or other solvents and be sealed from the external atmosphere by non-soluble ringing media
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Aqueouswaterbased
range includes: Non-AqueousSolventbased
range includes: Xylene
range includes: Toluene
range includes: AntifadewithDAPI
range includes: AntifadewithoutDAPI
range includes: PBS
range includes: Unknown
range includes: NotReported
display name: Mounting Medium
required: sms:false

ProcessingLocation
type: Class
comment: Site with an HTAN center where specimen processing occurs, if applicable. Any identifier used within the center to identify processing location. No PHI/PII is allowed.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Processing Location
required: sms:false

HistologyAssessmentBy
type: Class
comment: Text term describing who (in what role) made the histological assessments of the sample
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Pathologist
range includes: ResearchScientist
range includes: Other
range includes: Unknown
display name: Histology Assessment By
required: sms:false

HistologyAssessmentMedium
type: Class
comment: The method of assessment used to characterize histology
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Digital
range includes: Microscopy
range includes: Other
range includes: Unknown
display name: Histology Assessment Medium
required: sms:false

PreinvasiveMorphology
type: Class
comment: Histologic Morphology not included in ICD-O-3 morphology codes, for preinvasive lesions included in the HTAN
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Melanocytichyperplasia
range includes: Atypicalmelanocyticproliferation
range includes: Melanomainsitu-superficialspreading
range includes: Melanomainsitu-lentigomalignatype
range includes: Melanomainsitu-acral-lentiginous
range includes: Melanomainsitu-arisinginagiantcongenitalnevus
range includes: Persistentmelanomainsitu
range includes: Melanomainsitu-nototherwiseclassified
range includes: Scar-noresidualmelanoma
range includes: Invasivemelanoma-superficialspreading
range includes: Invasivemelanoma-nodulartype
range includes: Invasivemelanoma-lentigomaligna
range includes: Invasivemelanoma-acrallentiginous
range includes: Invasivemelanoma-desmoplastic
range includes: Invasivemelanoma-nevoid
range includes: Invasivemelanoma-other
range includes: NormalWDA
range includes: Reservecellhyperplasia
range includes: Squamousmetaplasia-mature
range includes: Squamousmetaplasia-immature
range includes: Milddysplasia
range includes: Moderatedysplasia
range includes: Severedysplasia
range includes: SquamousCarcinomainsitu
range includes: Atypicaladenomatoushyperplasia
range includes: Adenocarcinomainsitu-nonmucinous
range includes: Adenocarcinomainsitu-mucinous
range includes: BenigntumorNOS
range includes: Hamartoma
range includes: CarcinomaNOS
range includes: Nodiagnosispossible
display name: Preinvasive Morphology
required: sms:false

TumorInfiltratingLymphocytes
type: Class
comment: Measure of Tumor-Infiltrating Lymphocytes [Number]
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Tumor Infiltrating Lymphocytes
required: sms:false

DegreeofDysplasia
type: Class
comment: Information related to the presence of cells that look abnormal under a microscope but are not cancer. Records the degree of dysplasia for the cyst or lesion under consideration.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Normalorbasalcellhyperplasiaormetaplasia
range includes: Milddysplasia
range includes: Moderatedysplasia
range includes: Severedysplasia
range includes: CarcinomainSitu
range includes: Unknown
display name: Degree of Dysplasia
required: sms:false

DysplasiaFraction
type: Class
comment: Resulting value to represent the number of pieces of dysplasia divided by the total number of pieces. [Text: max length 5]
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Dysplasia Fraction
required: sms:false

NumberProliferatingCells
type: Class
comment: Numeric value that represents the count of proliferating cells determined during pathologic review of the sample slide(s).
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Number Proliferating Cells
required: sms:false

PercentEosinophilInfiltration
type: Class
comment: Numeric value to represent the percentage of infiltration by eosinophils in a tumor sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Eosinophil Infiltration
required: sms:false

PercentGranulocyteInfiltration
type: Class
comment: Numeric value to represent the percentage of infiltration by granulocytes in a tumor sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Granulocyte Infiltration
required: sms:false

PercentInflamInfiltration
type: Class
comment: Numeric value to represent local response to cellular injury, marked by capillary dilatation, edema and leukocyte infiltration; clinically, inflammation is manifest by redness, heat, pain, swelling and loss of function, with the need to heal damaged tissue.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Inflam Infiltration
required: sms:false

PercentLymphocyteInfiltration
type: Class
comment: Numeric value to represent the percentage of infiltration by lymphocytes in a solid tissue normal sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Lymphocyte Infiltration
required: sms:false

PercentMonocyteInfiltration
type: Class
comment: Numeric value to represent the percentage of monocyte infiltration in a sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Monocyte Infiltration
required: sms:false

PercentNecrosis
type: Class
comment: Numeric value to represent the percentage of cell death in a malignant tumor sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Necrosis
required: sms:false

PercentNeutrophilInfiltration
type: Class
comment: Numeric value to represent the percentage of infiltration by neutrophils in a tumor sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Neutrophil Infiltration
required: sms:false

PercentNormalCells
type: Class
comment: Numeric value to represent the percentage of normal cell content in a malignant tumor sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Normal Cells
required: sms:false

PercentStromalCells
type: Class
comment: Numeric value to represent the percentage of reactive cells that are present in a malignant tumor sample or specimen but are not malignant such as fibroblasts, vascular structures, etc.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Stromal Cells
required: sms:false

PercentTumorCells
type: Class
comment: Numeric value that represents the percentage of infiltration by tumor cells in a sample.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Tumor Cells
required: sms:false

PercentTumorNuclei
type: Class
comment: Numeric value to represent the percentage of tumor nuclei in a malignant neoplasm sample or specimen.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Percent Tumor Nuclei
required: sms:false

FiducialMarker
type: Class
comment: Imaging specific: fiducial markers for the alignment of images taken across multiple rounds of imaging.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: NuclearStain-DAPI
range includes: FluorescentBeads
range includes: GridSlides-Hemocytometer
range includes: AdhesiveMarkers
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Fiducial Marker
required: sms:false

SlicingMethod
type: Class
comment: Imaging specific: the method by which the tissue was sliced.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Vibratome
range includes: Cryosectioning
range includes: Tissuemolds
range includes: Slidingmicrotome
range includes: Sectioning
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Slicing Method
required: sms:false

LysisBuffer
type: Class
comment: scRNA-seq specific: Type of lysis buffer used
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Lysis Buffer
required: sms:false

MethodofNucleicAcidIsolation
type: Class
comment: Bulk RNA & DNA-seq specific: method used for nucleic acid isolation. E.g. Qiagen Allprep, Qiagen miRNAeasy. [Text - max length 100]
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Method of Nucleic Acid Isolation
required: sms:false

Biosample
type: Class
comment: TBD
subclass of: Thing
is part of: schema.biothings.io
display name: Biosample
required: sms:false

SRRSBiospecimen
type: Class
comment: SRRS-specific HTAN biological entity; this can be tissue, blood, analyte and subsamples of those, however it can be described via fewer attributes than a standard HTAN specimen
subclass of: Biosample
is part of: schema.biothings.io
display name: SRRS Biospecimen
required: sms:false
requires component: Patient
requires dependency: Component
requires dependency: HTANBiospecimenID
requires dependency: SourceHTANBiospecimenID
requires dependency: HTANParentID
requires dependency: AdjacentBiospecimenIDs
requires dependency: BiospecimenType
requires dependency: TimepointLabel
requires dependency: CollectionDaysfromIndex
requires dependency: AcquisitionMethodType
requires dependency: IschemicTime
requires dependency: IschemicTemperature
requires dependency: CollectionMedia
requires dependency: TopographyCode
requires dependency: AdditionalTopography
requires dependency: FixativeType
requires dependency: StorageMethod
requires dependency: PreinvasiveMorphology
requires dependency: HistologicMorphologyCode
requires dependency: PreservationMethod
requires dependency: ProcessingDaysfromIndex
requires dependency: ProtocolLink

IschemicTime
type: Class
comment: Duration of time, in seconds, between when the specimen stopped receiving oxygen and when it was preserved or processed. Integer value.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Ischemic Time
required: sms:false

IschemicTemperature
type: Class
comment: Specify whether specimen experienced warm or cold ischemia.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: WarmIschemia
range includes: ColdIschemia
range includes: Ambientair
range includes: 4Cwetice
range includes: Negative-20C
range includes: DryIce
range includes: LiquidNitrogen
range includes: Unknown
display name: Ischemic Temperature
required: sms:false

TopographyCode
type: Class
comment: Topography Code, indicating site within the body, based on ICD-O-3.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: C00.0
range includes: C00.1
range includes: C00.2
range includes: C00.3
range includes: C00.4
range includes: C00.5
range includes: C00.6
range includes: C00.8
range includes: C01.9
range includes: C02.0
range includes: C02.1
range includes: C02.2
range includes: C02.3
range includes: C02.4
range includes: C02.8
range includes: C02.9
range includes: C03.0
range includes: C03.1
range includes: C03.9
range includes: C04.0
range includes: C04.1
range includes: C04.8
range includes: C04.9
range includes: C05.0
range includes: C05.1
range includes: C05.2
range includes: C05.8
range includes: C05.9
range includes: C06.0
range includes: C06.1
range includes: C06.2
range includes: C06.8
range includes: C06.9
range includes: C07.9
range includes: C08.0
range includes: C08.1
range includes: C08.8
range includes: C08.9
range includes: C09.0
range includes: C09.1
range includes: C09.8
range includes: C09.9
range includes: C10.0
range includes: C10.1
range includes: C10.2
range includes: C10.3
range includes: C10.4
range includes: C10.8
range includes: C10.9
range includes: C11.0
range includes: C11.1
range includes: C11.2
range includes: C11.3
range includes: C11.8
range includes: C11.9
range includes: C12.9
range includes: C13.0
range includes: C13.1
range includes: C13.2
range includes: C13.8
range includes: C13.9
range includes: C14.0
range includes: C14.2
range includes: C14.8
range includes: C15.0
range includes: C15.1
range includes: C15.2
range includes: C15.3
range includes: C15.4
range includes: C15.5
range includes: C15.8
range includes: C15.9
range includes: C16.0
range includes: C16.1
range includes: C16.2

AdditionalTopography
type: Class
comment: Topography not included in the ICD-O-3 Topography codes.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Skinofscalp
range includes: Skinofeyelid
range includes: Skinofnose
range includes: Skinoflip
range includes: Skinofear
range includes: Skinofneck
range includes: Skinofotherpartsofface
range includes: Skinofchest
range includes: Skinofback
range includes: Skinofabdomen
range includes: Skinoftrunk
range includes: Skinofbreast
range includes: Skinofupperlimbandshoulder
range includes: Skinofpalm
range includes: Skinoflowerlimbandhip
range includes: Skinofsole
range includes: Skinofpenis
range includes: Skinofscrotum
range includes: Skinofvulva
range includes: SkinNOS
range includes: HilarAirway
range includes: Peri-tumoralAirway
range includes: NotReported
display name: Additional Topography
required: sms:false

HistologicMorphologyCode
type: Class
comment: The microscopic anatomy of normal and abnormal cells and tissues of the specimen as captured in the morphology codes of the International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3). Example - 8010/0
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Histologic Morphology Code
required: sms:true

PreservationMethod
type: Class
comment: Text term that represents the method used to preserve the sample.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Cryopreserved
range includes: Cryopreservationinliquidnitrogen-deadtissue
range includes: Cryopreservationindryice-deadtissue
range includes: Cryopreservationinliquidnitrogen-livecells
range includes: Formalinfixedparaffinembedded-FFPE
range includes: Formalinfixed-unbuffered
range includes: Formalinfixed-buffered
range includes: Fresh
range includes: OCT
range includes: SnapFrozen
range includes: Frozen
range includes: Negative80DegC
range includes: LiquidNitrogen
range includes: Freshdissociated
range includes: Freshdissociatedandsinglecellsorted
range includes: Freshdissociatedandsinglecellsortedintoplates
range includes: Methacarnfixedparaffinembedded-MFPE
range includes: Unknown
range includes: NotReported
display name: Preservation Method
required: sms:true

OtherAssay
type: Class
comment: Metadata applying to any assay without standard descriptors. Can be used as a placeholder for minimal amount of metadata until the assay descriptors are standardized
subclass of: Assay
subclass of: DataType
is part of: schema.biothings.io
display name: Other Assay
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: AssayType

AssayType
type: Class
comment: The type and level of assay this metadata applies to (e.g. RPPA, NanoString DSP, etc.)
subclass of: Assay
is part of: schema.biothings.io
display name: Assay Type
required: sms:true

ExSeqMinimal
type: Class
comment: Minimal metadata for the ExSeq assay
subclass of: Assay
is part of: schema.biothings.io
display name: ExSeq Minimal
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: AssayType

ScRNA-seqLevel1
type: Class
comment: Single-cell RNA-seq [EFO_0008913]
subclass of: Sequencing
is part of: schema.biothings.io
display name: scRNA-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: CryopreservedCellsinSample
requires dependency: SingleCellIsolationMethod
requires dependency: DissociationMethod
requires dependency: LibraryConstructionMethod
requires dependency: ReadIndicator
requires dependency: Read1
requires dependency: Read2
requires dependency: EndBias
requires dependency: ReverseTranscriptionPrimer
requires dependency: SpikeIn
requires dependency: SequencingPlatform
requires dependency: TotalNumberofInputCells
requires dependency: InputCellsandNuclei
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SingleCellDissociationDaysfromIndex
requires dependency: SequencingLibraryConstructionDaysfromIndex
requires dependency: NucleicAcidCaptureDaysfromIndex
requires dependency: ProtocolLink
requires dependency: TechnicalReplicateGroup

NucleicAcidSource
type: Class
comment: The source of the input nucleic molecule
subclass of: Sequencing
is part of: schema.biothings.io
range includes: SingleCell
range includes: BulkWholeCell
range includes: SingleNucleus
range includes: BulkNuclei
range includes: Micro-region
display name: Nucleic Acid Source
required: sms:true

CryopreservedCellsinSample
type: Class
comment: Indicate if library preparation was based on revived frozen cells.
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Cryopreserved Cells in Sample
required: sms:true

SingleCellIsolationMethod
type: Class
comment: The method by which cells are isolated into individual reaction containers at a single cell resolution (e.g. wells, micro-droplets)
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: MicrofluidicsChip
range includes: Droplets
range includes: FACS
range includes: Plates
range includes: 10x
range includes: NucleiIsolation
display name: Single Cell Isolation Method
required: sms:true

DissociationMethod
type: Class
comment: The tissue dissociation method used for scRNASeq or scATAC-seq assays
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: GentleMACS
range includes: Dounce
range includes: EnzymaticDigestion
range includes: NotApplicable
display name: Dissociation Method
required: sms:true

LibraryConstructionMethod
type: Class
comment: Process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors [OBI_0000711]
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Smart-seq2
range includes: Smart-SeqV4
range includes: 10xV1.0
range includes: 10xV1.1
range includes: 10xV2
range includes: 10xV3
range includes: 10xV3.1
range includes: CEL-seq2
range includes: Drop-seq
range includes: InDropsV2
range includes: InDropsV3
range includes: TruDrop
range includes: Sci-ATAC-seq
range includes: NexteraXT
range includes: 10xMultiome
range includes: 10xFLEX
range includes: 10xGEM3'
range includes: 10xGEM5'
display name: Library Construction Method
required: sms:true

ReadIndicator
type: Class
comment: Indicate if this is Read 1 (R1), Read 2 (R2), Index Reads (I1), or Other
subclass of: Sequencing
is part of: schema.biothings.io
range includes: R1
range includes: R2
range includes: R1&R2
range includes: I1
range includes: Other
display name: Read Indicator
required: sms:true

Read1
type: Class
comment: Read 1 content description
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandUMI
range includes: CDNA
display name: Read1
required: sms:true

Read2
type: Class
comment: Read 2 content description
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandUMI
range includes: CDNA
display name: Read2
required: sms:true

EndBias
type: Class
comment: The end of the cDNA molecule that is preferentially sequenced, e.g. 3/5 prime tag/end or the full length transcript
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: 3Prime
range includes: 5Prime
range includes: FullLengthTranscript
display name: End Bias
required: sms:true

ReverseTranscriptionPrimer
type: Class
comment: An oligo to which new deoxyribonucleotides can be added by DNA polymerase [SO_0000112]. The type of primer used for reverse transcription, e.g. oligo-dT or random primer. This allows users to identify content of the cDNA library input e.g. enriched for mRNA
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: Oligo-dT
range includes: Poly-dT
range includes: Featurebarcoding
range includes: Random
display name: Reverse Transcription Primer
required: sms:true

SpikeIn
type: Class
comment: A set of known synthetic RNA molecules with known sequence that are added to the cell lysis mix
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: ERCC
range includes: OtherSpikeIn
range includes: NoSpikeIn
range includes: PhiX
display name: Spike In
required: sms:true

SequencingPlatform
type: Class
comment: A platform is an object aggregate that is the set of instruments and software needed to perform a process [OBI_0000050]. Specific model of the sequencing instrument.
subclass of: Device
is part of: schema.biothings.io
range includes: IlluminaNextSeq500
range includes: IlluminaNextSeq550
range includes: IlluminaNextSeq2500
range includes: IlluminaNovaSeq6000
range includes: IlluminaMiSeq
range includes: 454GSFLXTitanium
range includes: ABSOLiD4
range includes: ABSOLiD2
range includes: ABSOLiD3
range includes: CompleteGenomics
range includes: IlluminaHiSeqXTen
range includes: IlluminaHiSeqXFive
range includes: IlluminaGenomeAnalyzerII
range includes: IlluminaGenomeAnalyzerIIx
range includes: IlluminaHiSeq2000
range includes: IlluminaHiSeq2500
range includes: IlluminaHiSeq4000
range includes: IlluminaNextSeq
range includes: IonTorrentPGM
range includes: IonTorrentProton
range includes: IonTorrentS5
range includes: PacBioRS
range includes: NovaSeq6000
range includes: NovaSeqS4
range includes: UltimaGenomicsUG100
range includes: OxfordNanoporeminION
range includes: GridION
range includes: PromethION
range includes: PacBioSequel2
range includes: Revio
range includes: IlluminaNextSeq1000
range includes: IlluminaNextSeq2000
range includes: Other
range includes: Unknown
range includes: NotReported
display name: Sequencing Platform
required: sms:true

TotalNumberofInputCells
type: Class
comment: Number of cells loaded/placed on plates
subclass of: Sequencing
is part of: schema.biothings.io
display name: Total Number of Input Cells
required: sms:true

InputCellsandNuclei
type: Class
comment: Number of cells and number of nuclei input; entry format: number, number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Input Cells and Nuclei
required: sms:true

LibraryPreparationDaysfromIndex
type: Class
comment: Number of days between sample for assay was received in lab and the libraries were prepared for sequencing [number]. If not applicable please enter 'Not Applicable'
subclass of: Sequencing
is part of: schema.biothings.io
display name: Library Preparation Days from Index
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

SingleCellDissociationDaysfromIndex
type: Class
comment: Number of days between sample for single cell assay was received in lab and when the sample was dissociated and cells were isolated [number]. If not applicable please enter 'Not Applicable'
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Single Cell Dissociation Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

SequencingLibraryConstructionDaysfromIndex
type: Class
comment: Number of days between sample for assay was received in lab and day of sequencing library construction [number]. If not applicable please enter 'Not Applicable'
subclass of: Sequencing
is part of: schema.biothings.io
display name: Sequencing Library Construction Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

NucleicAcidCaptureDaysfromIndex
type: Class
comment: Number of days between sample for single cell assay was received in lab and day of nucleic acid capture part of library construction (in number of days since sample received in lab) [number]. If not applicable please enter 'Not Applicable'
subclass of: Sequencing
is part of: schema.biothings.io
display name: Nucleic Acid Capture Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

TechnicalReplicateGroup
type: Class
comment: A common term for all files belonging to the same cell or library. Provide a numbering of each library prep batch (can differ from encapsulation and sequencing batch)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Technical Replicate Group
required: sms:false

ScRNA-seqLevel2
type: Class
comment: Alignment workflows downstream of scRNA-seq Level 1
subclass of: Sequencing
is part of: schema.biothings.io
display name: scRNA-seq Level 2
required: sms:false
requires component: ScRNA-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: ScRNAseqWorkflowType
requires dependency: WorkflowVersion
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowLink
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: GenomeAnnotationURL
requires dependency: Checksum
requires dependency: WhitelistCellBarcodeFileLink
requires dependency: CellBarcodeTag
requires dependency: UMITag
requires dependency: AppliedHardTrimming

ScRNAseqWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: CellRanger
range includes: STARsolo
range includes: HCAOptimus
range includes: DropEST
range includes: SEQC
range includes: Cufflinks
range includes: DEXSeq
range includes: HTSeq-FPKM
range includes: Cellannotation
range includes: Differentiationtrajectoryanalysis
range includes: Other
display name: scRNAseq Workflow Type
required: sms:true

WorkflowVersion
type: Class
comment: Major version of the workflow (e.g. Cell Ranger v3.1)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Workflow Version
required: sms:true

ScRNAseqWorkflowParametersDescription
type: Class
comment: Parameters used to run the workflow. scRNA-seq level 3: e.g. Normalization and log transformation, ran empty drops or doublet detection, used filter on # genes/cell, etc. scRNA-seq Level 4: dimensionality reduction with PCA and 50 components, nearest-neighbor graph with k = 20 and Leiden clustering with resolution = 1, UMAP visualization using 50 PCA components, marker genes used to annotate cell types, information about droplet matrix (all barcodes) to cell matrix (only informative barcodes representing real cells) conversion
subclass of: Sequencing
is part of: schema.biothings.io
display name: scRNAseq Workflow Parameters Description
required: sms:true

WorkflowLink
type: Class
comment: Link to workflow or command. DockStore.org recommended. URL
subclass of: Sequencing
is part of: schema.biothings.io
display name: Workflow Link
required: sms:true

GenomicReference
type: Class
comment: Exact version of the human genome reference used in the alignment of reads (e.g. GCF_000001405.39)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Genomic Reference
required: sms:true

GenomicReferenceURL
type: Class
comment: Link to human genome sequence (e.g. ftp://ftp.ebi.ac.uk/pub/databases/gencode/Gencode_human/release_34/GRCh38.primary_assembly.genome.fa.gz)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Genomic Reference URL
required: sms:true

GenomeAnnotationURL
type: Class
comment: Link to the human genome annotation (GTF) file (e.g. ftp://ftp.ebi.ac.uk/pub/databases/gencode/Gencode_human/release_34/gencode.v34.annotation.gtf.gz)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Genome Annotation URL
required: sms:true

WhitelistCellBarcodeFileLink
type: Class
comment: Link to file listing all possible cell barcodes. URL
subclass of: Sequencing
is part of: schema.biothings.io
display name: Whitelist Cell Barcode File Link
required: sms:true

CellBarcodeTag
type: Class
comment: SAM tag for cell barcode field; please provide a valid cell barcode tag (e.g. CB:Z)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Cell Barcode Tag
required: sms:true

UMITag
type: Class
comment: SAM tag for the UMI field; please provide a valid UB, UMI (e.g. UB:Z or UR:Z)
subclass of: Sequencing
is part of: schema.biothings.io
display name: UMI Tag
required: sms:true

AppliedHardTrimming
type: Class
comment: Was Hard Trimming applied
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Yes-AppliedHardTrimming
range includes: No
display name: Applied Hard Trimming
required: sms:true

ScRNA-seqLevel3
type: Class
comment: Gene and Isoform expression files
subclass of: Sequencing
is part of: schema.biothings.io
display name: scRNA-seq Level 3
required: sms:false
requires component: ScRNA-seqLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: DataCategory
requires dependency: MatrixType
requires dependency: LinkedMatrices
requires dependency: CellMedianNumberReads
requires dependency: CellMedianNumberGenes
requires dependency: CellTotal
requires dependency: ScRNAseqWorkflowType
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowLink
requires dependency: WorkflowVersion

DataCategory
type: Class
comment: Specific content type of the data file.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: GeneExpression
range includes: TranscriptExpression
range includes: ExonExpressionQuantification
range includes: GeneExpressionQuantification
range includes: IsoformExpressionQuantification
range includes: SpliceJunctionQuantification
range includes: Other
display name: Data Category
required: sms:true

MatrixType
type: Class
comment: Type of data stored in matrix.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: RawCounts
range includes: NormalizedCounts
range includes: ScaledCounts
range includes: BatchCorrectedCounts
display name: Matrix Type
required: sms:true

LinkedMatrices
type: Class
comment: All matrices associated with every part of a SingleCellExperiment object. Comma-delimited list of filenames
subclass of: Sequencing
is part of: schema.biothings.io
display name: Linked Matrices
required: sms:false

CellMedianNumberReads
type: Class
comment: Median number of reads per cell. Number
subclass of: ScRNA-seqLevel3
is part of: schema.biothings.io
display name: Cell Median Number Reads
required: sms:true

CellMedianNumberGenes
type: Class
comment: Median number of genes detected per cell. Number
subclass of: ScRNA-seqLevel3
is part of: schema.biothings.io
display name: Cell Median Number Genes
required: sms:true

CellTotal
type: Class
comment: Number of sequenced cells. Applies to raw counts matrix only.
subclass of: ScRNA-seqLevel3
is part of: schema.biothings.io
display name: Cell Total
required: sms:true

ScRNA-seqLevel4
type: Class
comment: Data represents the relationships between cells derived from Level 3 expression data and shown as tSNE or UMAP coordinates per cell, plus all other cell-specific meta information (e.g., cell type)
subclass of: Sequencing
is part of: schema.biothings.io
display name: scRNA-seq Level 4
required: sms:false
requires component: ScRNA-seqLevel3
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: ScRNAseqWorkflowType
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowVersion
requires dependency: WorkflowLink

Slide-seqLevel1
type: Class
comment: Raw sequencing files for the Slide-seq assay.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: ReadIndicator
requires dependency: SpatialRead1
requires dependency: SpatialRead2
requires dependency: EndBias
requires dependency: ReverseTranscriptionPrimer
requires dependency: SpatialBarcodeOffset
requires dependency: SpatialBarcodeandUMI
requires dependency: SpikeIn
requires dependency: SequencingPlatform
requires dependency: TechnicalReplicateGroup
requires dependency: ProtocolLink
requires dependency: SpatialLibraryConstructionMethod
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SequencingLibraryConstructionDaysfromIndex
requires dependency: NucleicAcidCaptureDaysfromIndex

SpatialRead1
type: Class
comment: Read 1 content description
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: CDNA
range includes: SpatialBarcodeandUMI
display name: Spatial Read1
required: sms:true

SpatialRead2
type: Class
comment: Read 2 content description
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: CDNA
range includes: SpatialBarcodeandUMI
display name: Spatial Read2
required: sms:true

SpatialBarcodeOffset
type: Class
comment: Offset in sequence for spot barcode read (in bp): number
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Spatial Barcode Offset
required: sms:true

SpatialBarcodeandUMI
type: Class
comment: Spot and transcript identifiers
subclass of: SpatialTranscriptomics
subclass of: SpatialRead1
subclass of: SpatialRead2
is part of: schema.biothings.io
display name: Spatial Barcode and UMI
required: sms:true
requires dependency: SpatialBarcodeOffset
requires dependency: SpatialBarcodeLength
requires dependency: UMIBarcodeOffset
requires dependency: UMIBarcodeLength
validation rules: num

SpatialLibraryConstructionMethod
type: Class
comment: Process which results in the creation of a library from fragments of DNA using cloning vectors or oligonucleotides with the role of adaptors [OBI_0000711]
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: Smart-seq2
range includes: Smart-SeqV4
range includes: 10xV1.0
range includes: 10xV1.1
range includes: 10xV2
range includes: 10xV3
range includes: 10xV3.1
range includes: Drop-seq
range includes: InDropsV2
range includes: InDropsV3
range includes: TruDrop
range includes: NexteraXT
display name: Spatial Library Construction Method
required: sms:true

SpatialTranscriptomics
type: Class
comment: TBD
subclass of: Thing
is part of: schema.biothings.io
display name: Spatial Transcriptomics
required: sms:false

Slide-seqLevel2
type: Class
comment: Aligned sequencing files and QC for the Slide-seq assay.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Level 2
required: sms:false
requires component: Slide-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: Slide-seqWorkflowType
requires dependency: WorkflowVersion
requires dependency: Slide-seqWorkflowParameterDescription
requires dependency: WorkflowLink
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: GenomeAnnotationURL
requires dependency: Checksum
requires dependency: SpatialBarcodeTag
requires dependency: MatchedSpatialBarcodeTag
requires dependency: UMITag
requires dependency: AppliedHardTrimming

Slide-seqWorkflowType
type: Class
comment: Generic name for the workflow used to analyze the Slide-seq data set. String
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Workflow Type
required: sms:true

Slide-seqWorkflowParameterDescription
type: Class
comment: Parameters used to run the Slide-seq workflow. String
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Workflow Parameter Description
required: sms:true

SpatialBarcodeTag
type: Class
comment: SAM tag for spot barcode field; please provide a valid spot barcode tag (e.g. CB:Z)
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Spatial Barcode Tag
required: sms:true

MatchedSpatialBarcodeTag
type: Class
comment: SAM tag for matched spot barcode field; please provide a valid spot barcode tag (e.g. CB:Z) (Slide-seq specific)
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Matched Spatial Barcode Tag
required: sms:true

Slide-seqLevel3
type: Class
comment: Gene matrices with features and barcodes for Slide-seq as well as spatial information (bead location files).
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Level 3
required: sms:false
requires component: Slide-seqLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: RunID
requires dependency: SequencingBatchID
requires dependency: DataCategory
requires dependency: MatrixType
requires dependency: Slide-seqWorkflowType
requires dependency: WorkflowVersion
requires dependency: Slide-seqWorkflowParameterDescription
requires dependency: WorkflowLink
requires dependency: BeadsTotal
requires dependency: MedianUMICountsperSpot
requires dependency: MedianNumberGenesperSpatialSpot
requires dependency: Slide-seqBeadFileType
requires dependency: Slide-seqFragmentSize

RunID
type: Class
comment: A unique identifier for this individual run (typically associated with a single slide) of the spatial transcriptomic processing workflow.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Run ID
required: sms:true

SequencingBatchID
type: Class
comment: Links samples to a specific local sequencer run. Can be string or 'null'
subclass of: Sequencing
is part of: schema.biothings.io
display name: Sequencing Batch ID
required: sms:true

BeadsTotal
type: Class
comment: Number of sequenced beads. Applies to raw counts matrix only. Integer
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Beads Total
required: sms:false

MedianUMICountsperSpot
type: Class
comment: The median number of UMI counts per tissue covered spot.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Median UMI Counts per Spot
required: sms:true
validation rules: num

MedianNumberGenesperSpatialSpot
type: Class
comment: The median number of genes detected per spot under tissue-associated barcode. Detection is defined as the presence of at least 1 UMI count.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Median Number Genes per Spatial Spot
required: sms:true
validation rules: num

Slide-seqBeadFileType
type: Class
comment: The type of Level 3 file submitted as part of the Slide-seq workflow.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: MatrixFeatures
range includes: MatrixBarcodes
range includes: AllBeadLocations
range includes: AllBeadBarcodes
range includes: MatchedBeadBarcodes
range includes: MatchedBeadLocations
range includes: NotApplicable
display name: Slide-seq Bead File Type
required: sms:true

Slide-seqFragmentSize
type: Class
comment: Average cDNA length associated with the experiemtn. Integer
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide-seq Fragment Size
required: sms:false

MatrixFeatures
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: Matrix Features
required: sms:false

MatrixBarcodes
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: Matrix Barcodes
required: sms:false

AllBeadLocations
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: All Bead Locations
required: sms:false

AllBeadBarcodes
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: All Bead Barcodes
required: sms:false

MatchedBeadBarcodes
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: Matched Bead Barcodes
required: sms:false

MatchedBeadLocations
type: Class
comment: TBD
subclass of: Slide-seqBeadFileType
is part of: schema.biothings.io
display name: Matched Bead Locations
required: sms:false

NotApplicable
type: Class
comment: TBD
subclass of: TargetCaptureKit
subclass of: SomaticVariantsSampleType
subclass of: HistoryofPriorColonPolyps
subclass of: FamilyColonCancerHistoryIndicator
subclass of: FamilyMedicalHistoryColorectalPolypDiagnosis
subclass of: PatientColonoscopyPerformedIndicator
subclass of: ReplicateType
subclass of: DissociationMethod
subclass of: LibraryStrand
subclass of: Immunosuppression
subclass of: COVID19OccurrenceIndicator
subclass of: COVID19PositiveLabTestIndicator
subclass of: COVID19CancerTreatmentFollowup
subclass of: ImmediateFamilyHistoryEndometrialCancer
subclass of: ImmediateFamilyHistoryOvarianCancer
subclass of: ColorectalCancerKRASIndicator
subclass of: ColonPolypOccurenceIndicator
subclass of: FamilyHistoryColorectalPolyp
subclass of: ColorectalPolypNewIndicator
subclass of: HormoneTherapyBreastCancerPreventionIndicator
subclass of: GliomaSpecificRadiationField
subclass of: SupraTentorialEpendymomaMolecularSubgroup
subclass of: RefluxTreatmentType
subclass of: COVID19ComplicationsSeverity
subclass of: PatientInflammatoryBowelDiseasePersonalMedicaHistory
subclass of: ColorectalCancerTumorBorderConfiguration
subclass of: ColorectalPolypShape
subclass of: InfraTentorialEpendymomaMolecularSubgroup
subclass of: SpecimenLaterality
subclass of: LabTestsforMMRStatus
subclass of: Slide-seqBeadFileType
subclass of: GliomaSpecificMetastasisSites
subclass of: COVID19AntibodyTesting
subclass of: ColorectalPolypAdenomaType
subclass of: LastKnownDiseaseStatus
subclass of: CutaneousMelanomaAdditionalFindings
subclass of: CauseofDeath
subclass of: TumorGrade
subclass of: ImagingAssayType
subclass of: ExtentofTumorResection
subclass of: TestResult
subclass of: StorageMethod
subclass of: MolecularAnalysisMethod
subclass of: ConcomitantMedicationReceivedType
subclass of: HereditaryCancerPredispositionSyndrome
subclass of: CancerAssociatedGeneMutations
subclass of: MutationalSignatures
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Not Applicable
required: sms:false

BulkRNA-seqLevel1
type: Class
comment: Bulk RNA-seq [EFO_0003738]
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk RNA-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: LibraryLayout
requires dependency: ReadIndicator
requires dependency: NucleicAcidSource
requires dependency: Micro-regionSeqPlatform
requires dependency: ROITag
requires dependency: SequencingPlatform
requires dependency: SequencingBatchID
requires dependency: ReadLength
requires dependency: LibrarySelectionMethod
requires dependency: LibraryPreparationKitName
requires dependency: LibraryPreparationKitVendor
requires dependency: LibraryPreparationKitVersion
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SpikeIn
requires dependency: AdapterName
requires dependency: AdapterSequence
requires dependency: BaseCallerName
requires dependency: BaseCallerVersion
requires dependency: FlowCellBarcode
requires dependency: FragmentMaximumLength
requires dependency: FragmentMeanLength
requires dependency: FragmentMinimumLength
requires dependency: FragmentStandardDeviationLength
requires dependency: LaneNumber
requires dependency: LibraryStrand
requires dependency: MultiplexBarcode
requires dependency: SizeSelectionRange
requires dependency: TargetDepth
requires dependency: ToTrimAdapterSequence
requires dependency: TranscriptIntegrityNumber
requires dependency: RIN
requires dependency: DV200
requires dependency: AdapterContent
requires dependency: BasicStatistics
requires dependency: Encoding
requires dependency: KmerContent
requires dependency: OverrepresentedSequences
requires dependency: PerBaseNContent
requires dependency: PerBaseSequenceContent
requires dependency: PerBaseSequenceQuality
requires dependency: PerSequenceGCContent
requires dependency: PerSequenceQualityScore
requires dependency: PerTileSequenceQuality
requires dependency: PercentGCContent
requires dependency: SequenceDuplicationLevels
requires dependency: SequenceLengthDistribution
requires dependency: TotalReads
requires dependency: QCWorkflowType
requires dependency: QCWorkflowVersion
requires dependency: QCWorkflowLink

LibraryLayout
type: Class
comment: Sequencing read type
subclass of: Sequencing
is part of: schema.biothings.io
range includes: PairedEnd
range includes: SingleRead
range includes: Mid-length
range includes: LongRead
display name: Library Layout
required: sms:true

Micro-regionSeqPlatform
type: Class
comment: The platform used for micro-regional RNA sequencing (if applicable)
subclass of: Sequencing
is part of: schema.biothings.io
range includes: RarecytePick-Seq
range includes: LaserCaptureMicrodissection
display name: Micro-region Seq Platform
required: sms:false

ROITag
type: Class
comment: The tag or grouping used to identify the ROI in micro-regional RNA sequencing (if applicable). Must match the ROI tag within the count matrix in level 3.
subclass of: Sequencing
is part of: schema.biothings.io
display name: ROI Tag
required: sms:false

ReadLength
type: Class
comment: The length of the sequencing reads. Can be integer, null
subclass of: Sequencing
is part of: schema.biothings.io
display name: Read Length
required: sms:true

LibrarySelectionMethod
type: Class
comment: How RNA molecules are isolated.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: HybridSelection
range includes: PCR
range includes: AffinityEnrichment
range includes: Poly-TEnrichment
range includes: Random
range includes: RRNADepletion
range includes: MiRNASizeFractionation
range includes: Other
display name: Library Selection Method
required: sms:true

LibraryPreparationKitName
type: Class
comment: Name of Library Preparation Kit. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Library Preparation Kit Name
required: sms:true

LibraryPreparationKitVendor
type: Class
comment: Vendor of Library Preparation Kit. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Library Preparation Kit Vendor
required: sms:true

LibraryPreparationKitVersion
type: Class
comment: Version of Library Preparation Kit. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Library Preparation Kit Version
required: sms:true

AdapterName
type: Class
comment: Name of the sequencing adapter. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Adapter Name
required: sms:false

AdapterSequence
type: Class
comment: Base sequence of the sequencing adapter. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Adapter Sequence
required: sms:false

BaseCallerName
type: Class
comment: Name of the base caller. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Base Caller Name
required: sms:false

BaseCallerVersion
type: Class
comment: Version of the base caller. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Base Caller Version
required: sms:false

FlowCellBarcode
type: Class
comment: Flow cell barcode. Wrong or missing information may affect analysis results. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Flow Cell Barcode
required: sms:false

FragmentMaximumLength
type: Class
comment: Maximum length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Fragment Maximum Length
required: sms:false

FragmentMeanLength
type: Class
comment: Mean length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Fragment Mean Length
required: sms:false

FragmentMinimumLength
type: Class
comment: Minimum length of the sequenced fragments (e.g., as predicted by Agilent Bioanalyzer). Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Fragment Minimum Length
required: sms:false

FragmentStandardDeviationLength
type: Class
comment: Standard deviation of the sequenced fragments length (e.g., as predicted by Agilent Bioanalyzer). Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Fragment Standard Deviation Length
required: sms:false

LaneNumber
type: Class
comment: The basic machine unit for sequencing. For Illumina machines, this reflects the physical lane number. Wrong or missing information may affect analysis results. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Lane Number
required: sms:false

LibraryStrand
type: Class
comment: Library stranded-ness.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Unstranded
range includes: FirstStranded
range includes: SecondStranded
range includes: NotApplicable
display name: Library Strand
required: sms:false

MultiplexBarcode
type: Class
comment: The barcode/index sequence used. Wrong or missing information may affect analysis results. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Multiplex Barcode
required: sms:false

SizeSelectionRange
type: Class
comment: Range of size selection. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Size Selection Range
required: sms:false

TargetDepth
type: Class
comment: The targeted read depth prior to sequencing. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Target Depth
required: sms:false

ToTrimAdapterSequence
type: Class
comment: Does the user suggest adapter trimming?
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Yes-TrimAdapterSequence
range includes: No
display name: To Trim Adapter Sequence
required: sms:false

TranscriptIntegrityNumber
type: Class
comment: Used to describe the quality of the starting material, esp. in regards to FFPE samples. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Transcript Integrity Number
required: sms:false

RIN
type: Class
comment: A numerical assessment of the integrity of RNA based on the entire electrophoretic trace of the RNA sample including the presence or absence of degradation products. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: RIN
required: sms:false

DV200
type: Class
comment: Represents the percentage of RNA fragments that are >200 nucleotides in size. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: DV200
required: sms:false

AdapterContent
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Adapter Content
required: sms:false

BasicStatistics
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Basic Statistics
required: sms:false

Encoding
type: Class
comment: Version of ASCII encoding of quality values found in the file. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Encoding
required: sms:false

KmerContent
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Kmer Content
required: sms:false

OverrepresentedSequences
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Overrepresented Sequences
required: sms:false

PerBaseNContent
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Base N Content
required: sms:false

PerBaseSequenceContent
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Base Sequence Content
required: sms:false

PerBaseSequenceQuality
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Base Sequence Quality
required: sms:false

PerSequenceGCContent
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Sequence GC Content
required: sms:false

PerSequenceQualityScore
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Sequence Quality Score
required: sms:false

PerTileSequenceQuality
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Per Tile Sequence Quality
required: sms:false

PercentGCContent
type: Class
comment: The overall %GC of all bases in all sequences. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Percent GC Content
required: sms:false

SequenceDuplicationLevels
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Sequence Duplication Levels
required: sms:false

SequenceLengthDistribution
type: Class
comment: State classification given by FASTQC for the metric. Metric specific details about the states are available on their website.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: FAIL
range includes: PASS
range includes: WARN
range includes: Unknown
range includes: NotReported
display name: Sequence Length Distribution
required: sms:false

TotalReads
type: Class
comment: Total number of reads per sample. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Total Reads
required: sms:false

QCWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: QC Workflow Type
required: sms:false

QCWorkflowVersion
type: Class
comment: Major version for a workflow. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: QC Workflow Version
required: sms:false

QCWorkflowLink
type: Class
comment: Link to workflow used. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: QC Workflow Link
required: sms:false

BulkRNA-seqLevel2
type: Class
comment: Bulk RNA-seq alignment protocol description
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk RNA-seq Level 2
required: sms:false
requires component: BulkRNA-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowUrl
requires dependency: AlignmentWorkflowType
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: Contamination
requires dependency: ContaminationError
requires dependency: MeanCoverage
requires dependency: MSIWorkflowLink
requires dependency: MSIScore
requires dependency: MSIStatus
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ProportionReadsMapped
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: ShortReads
requires dependency: Islowestlevel

AlignmentWorkflowUrl
type: Class
comment: Link to workflow used for read alignment. DockStore.org recommended. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Alignment Workflow Url
required: sms:true

AlignmentWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: BWA
range includes: BWAwithBQSR
range includes: BWA-aln
range includes: BWA-mem
range includes: BWAwithMarkDuplicatesandBQSR
range includes: STAR2-Pass
range includes: STAR2-PassChimeric
range includes: STAR2-PassGenome
range includes: STAR2-PassTranscriptome
range includes: Bowtie
range includes: Bismark
range includes: GSNAP
range includes: BSMAP
range includes: BSmooth
range includes: BS-Seeker2
range includes: BS-Seeker
range includes: RMAP
range includes: MethylCoder
range includes: BRAT-BW
range includes: Pash
range includes: Segemehl
range includes: Bisulfighter
range includes: BatMeth
range includes: LAST
range includes: ERNE-BS5
range includes: B-SOLANA
range includes: SOCS-B
range includes: BWA-meth
range includes: OtherAlignmentWorkflow
range includes: None
display name: Alignment Workflow Type
required: sms:true

IndexFileName
type: Class
comment: The name (or part of a name) of a file (of any type). String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Index File Name
required: sms:true

AverageBaseQuality
type: Class
comment: Average base quality collected from samtools. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Average Base Quality
required: sms:false

AverageInsertSize
type: Class
comment: Average insert size collected from samtools. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Average Insert Size
required: sms:false

AverageReadLength
type: Class
comment: Average read length collected from samtools. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Average Read Length
required: sms:false

Contamination
type: Class
comment: Fraction of reads coming from cross-sample contamination collected from GATK4. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Contamination
required: sms:false

ContaminationError
type: Class
comment: Estimation error of cross-sample contamination collected from GATK4. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Contamination Error
required: sms:false

MeanCoverage
type: Class
comment: Mean coverage for whole genome sequencing, or mean target coverage for whole exome and targeted sequencing, collected from Picard. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Mean Coverage
required: sms:false

MSIWorkflowLink
type: Class
comment: Link to method workflow (or command) used in estimating the MSI. URL
subclass of: Sequencing
is part of: schema.biothings.io
display name: MSI Workflow Link
required: sms:false

MSIScore
type: Class
comment: Numeric score denoting the aligned reads file's MSI score from MSIsensor. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: MSI Score
required: sms:false

MSIStatus
type: Class
comment: MSIsensor determination of either microsatellite stability or instability.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: MSI
range includes: MSI-low
range includes: MSI-high
range includes: MSS
display name: MSI Status
required: sms:false

PairsOnDiffCHR
type: Class
comment: Pairs on different chromosomes collected from samtools. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Pairs On Diff CHR
required: sms:false

TotalUniquelyMapped
type: Class
comment: Number of reads that map to genome. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Total Uniquely Mapped
required: sms:false

TotalUnmappedreads
type: Class
comment: Number of reads that did not map to genome. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Total Unmapped reads
required: sms:false

ProportionReadsDuplicated
type: Class
comment: Proportion of duplicated reads collected from samtools. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Reads Duplicated
required: sms:false

ProportionReadsMapped
type: Class
comment: Proportion of mapped reads collected from samtools. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Reads Mapped
required: sms:false

ProportionTargetsNoCoverage
type: Class
comment: Proportion of targets that did not reach 1X coverage over any base from Picard Tools. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Targets No Coverage
required: sms:false

ProportionBaseMismatch
type: Class
comment: Proportion of mismatched bases collected from samtools. Number
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Base Mismatch
required: sms:false

ShortReads
type: Class
comment: Number of reads that were too short. Integer
subclass of: Sequencing
is part of: schema.biothings.io
display name: Short Reads
required: sms:false

Islowestlevel
type: Class
comment: Denotes that the manifest represents the lowest data level submitted. Use when L1 data is missing
subclass of: ScRNA-seqLevel2
is part of: schema.biothings.io
range includes: Yes-Islowestlevel
range includes: No
display name: Is lowest level
required: sms:false

BulkRNA-seqLevel3
type: Class
comment: Bulk RNA-seq gene expression matrices
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk RNA-seq Level 3
required: sms:false
requires component: BulkRNA-seqLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: PseudoAlignmentUsed
requires dependency: DataCategory
requires dependency: ExpressionUnits
requires dependency: MatrixType
requires dependency: FusionGeneDetected
requires dependency: FusionGeneIdentity

PseudoAlignmentUsed
type: Class
comment: Pseudo aligners such as Kallisto or Salmon do not produce aligned reads BAM files. True indicates pseudoalignment was used.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Yes-PseudoAlignmentUsed
range includes: No
display name: Pseudo Alignment Used
required: sms:true

ExpressionUnits
type: Class
comment: How quantities are corrected for gene length
subclass of: Sequencing
is part of: schema.biothings.io
range includes: TPM
range includes: RPKM
range includes: FPKM
range includes: Counts
range includes: Other
range includes: NA
display name: Expression Units
required: sms:true

FusionGeneDetected
type: Class
comment: Was a fusion gene identified?
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Yes-FusionGeneDetected
range includes: No
range includes: Unknown
display name: Fusion Gene Detected
required: sms:false

FusionGeneIdentity
type: Class
comment: The gene symbols of fused genes.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: EWS-FLI
range includes: EWS-ERG
range includes: SYT-SSX1
range includes: SYT-SSX2
range includes: EWS-WT1
range includes: OtherFusionGene
display name: Fusion Gene Identity
required: sms:false
validation rules: list like

BulkWESLevel1
type: Class
comment: Bulk Whole Exome Sequencing raw files
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk WES Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: SequencingBatchID
requires dependency: LibraryLayout
requires dependency: ReadIndicator
requires dependency: LibrarySelectionMethod
requires dependency: ReadLength
requires dependency: TargetCaptureKit
requires dependency: LibraryPreparationKitName
requires dependency: LibraryPreparationKitVendor
requires dependency: LibraryPreparationKitVersion
requires dependency: SequencingPlatform
requires dependency: AdapterName
requires dependency: AdapterSequence
requires dependency: BaseCallerName
requires dependency: BaseCallerVersion
requires dependency: FlowCellBarcode
requires dependency: FragmentMaximumLength
requires dependency: FragmentMeanLength
requires dependency: FragmentMinimumLength
requires dependency: FragmentStandardDeviationLength
requires dependency: LaneNumber
requires dependency: MultiplexBarcode
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SizeSelectionRange
requires dependency: TargetDepth
requires dependency: ToTrimAdapterSequence

TargetCaptureKit
type: Class
comment: Description that can uniquely identify a target capture kit. Suggested value is a combination of vendor, kit name, and kit version.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: NotApplicable
range includes: CustomTargetsFileProvided
range includes: CustomAmpliSeqCancerHotspotGENIE-MDAAugmentedPanelv1-46Genes
range includes: CustomGENIE-DFCIOncoPanel-275Genes
range includes: CustomGENIE-DFCIOncopanel-300Genes
range includes: CustomGENIE-DFCIOncopanel-447Genes
range includes: CustomHaloPlexDLBCLPanel-370Genes
range includes: CustomLargeConstructCaptureTARGET-OSPanel-8Genes
range includes: CustomMSKIMPACTPanel-341Genes
range includes: CustomMSKIMPACTPanel-410Genes
range includes: CustomMSKIMPACTPanel-468Genes
range includes: CustomMyeloidGENIE-VICCPanel-37Genes
range includes: CustomPersonalisACEcpVAREPOP-APOLLOPanelv2
range includes: CustomPGDXSureSelectCancerSelectVAREPOP-APOLLOPanel-203Genes
range includes: CustomPGDXSureSelectCancerSelectVAREPOP-APOLLOPanel-88Genes
range includes: CustomSeqCapEZTARGET-OSPanel-7.0Mb
range includes: CustomSolidTumorGENIE-VICCPanel-34Genes
range includes: CustomSureSelectCGCI-BLGSPPanel-4.6Mb
range includes: CustomSureSelectCGCI-HTMCP-CCPanel-19.7Mb
range includes: CustomSureSelectGENIE-UHNPanel-555Genes
range includes: CustomSureSelectTARGET-AMLNBLWTPanel-2.8Mb
range includes: CustomTwistBroadExomev1.0-35.0Mb
range includes: CustomTwistBroadPanCancerPanel-396Genes
range includes: FoundationMedicineT5aPanel-322Genes
range includes: FoundationMedicineT7Panel-429Genes
range includes: IonAmpliSeqCancerHotspotPanelv2
range includes: IonAmpliSeqComprehensiveCancerPanel
range includes: NexteraDNAExome
range includes: NexteraRapidCaptureExomev1.2
range includes: SeqCapEZHGSCVCRomev2.1
range includes: SeqCapEZHumanExomev2.0
range includes: SeqCapEZHumanExomev3.0
range includes: SureSelectHumanAllExonv3
range includes: SureSelectHumanAllExonv4
range includes: SureSelectHumanAllExonv5
range includes: SureSelectHumanAllExonv5+UTR
range includes: TruSeqAmpliconCancerPanel
range includes: TruSeqExomeEnrichment-62Mb
range includes: TruSeqRNAExome
range includes: TruSightMyeloidSequencingPanel
range includes: XGenExomeResearchPanelv1.0
range includes: XGenUniversalBlockingOligo–TSHT-i5-25rxn
range includes: 25rxnxGenUniversalBlockingOligo–TSHT-i7
range includes: SureSelectHumanAllExonv6
range includes: Unknown
display name: Target Capture Kit
required: sms:true

BulkWESLevel2
type: Class
comment: Bulk Whole Exome Sequencing aligned files and QC
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk WES Level 2
required: sms:false
requires component: BulkWESLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowType
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: Contamination
requires dependency: ContaminationError
requires dependency: MeanCoverage
requires dependency: AdapterContent
requires dependency: BasicStatistics
requires dependency: Encoding
requires dependency: OverrepresentedSequences
requires dependency: PerBaseNContent
requires dependency: PerBaseSequenceContent
requires dependency: PerBaseSequenceQuality
requires dependency: PerSequenceGCContent
requires dependency: PerSequenceQualityScore
requires dependency: PerTileSequenceQuality
requires dependency: PercentGCContent
requires dependency: SequenceDuplicationLevels
requires dependency: SequenceLengthDistribution
requires dependency: QCWorkflowType
requires dependency: QCWorkflowVersion
requires dependency: QCWorkflowLink
requires dependency: MSIWorkflowLink
requires dependency: MSIScore
requires dependency: MSIStatus
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ProportionReadsMapped
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: ShortReads
requires dependency: ProportionCoverage10x
requires dependency: ProportionCoverage30X
requires dependency: Islowestlevel

ProportionCoverage10x
type: Class
comment: Proportion of all reference bases for whole genome sequencing, or targeted bases for whole exome and targeted sequencing, that achieves 10X or greater coverage from Picard Tools.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Coverage 10x
required: sms:false

ProportionCoverage30X
type: Class
comment: Proportion of all reference bases for whole genome sequencing, or targeted bases for whole exome and targeted sequencing, that achieves 30X or greater coverage from Picard Tools.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Coverage 30X
required: sms:false

BulkWESLevel3
type: Class
comment: Bulk Whole Exome Sequencing called variants
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk WES Level 3
required: sms:false
requires component: BulkWESLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: GermlineVariantsWorkflowURL
requires dependency: GermlineVariantsWorkflowType
requires dependency: SomaticVariantsWorkflowURL
requires dependency: SomaticVariantsWorkflowType
requires dependency: SomaticVariantsSampleType
requires dependency: StructuralVariantWorkflowURL
requires dependency: StructuralVariantWorkflowType

GermlineVariantsWorkflowURL
type: Class
comment: Link to workflow document, e.g. Github, DockStore.org recommended
subclass of: Sequencing
is part of: schema.biothings.io
display name: Germline Variants Workflow URL
required: sms:true

GermlineVariantsWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set
subclass of: Sequencing
is part of: schema.biothings.io
range includes: GATK4
range includes: OtherGermlineVariantsWorkflowType
range includes: None
display name: Germline Variants Workflow Type
required: sms:false

SomaticVariantsWorkflowURL
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Somatic Variants Workflow URL
required: sms:true

SomaticVariantsWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: CaVEMan
range includes: GATK4
range includes: MuTect2
range includes: MuSE
range includes: Pindel
range includes: SomaticSniper
range includes: VarScan2
range includes: OtherSomaticVariantsWorkflowType
range includes: None
display name: Somatic Variants Workflow Type
required: sms:false

SomaticVariantsSampleType
type: Class
comment: Is the sample case or control in somatic variant analysis
subclass of: Sequencing
is part of: schema.biothings.io
range includes: CaseSample
range includes: ControlSample
range includes: NotApplicable
display name: Somatic Variants Sample Type
required: sms:true

StructuralVariantWorkflowURL
type: Class
comment: Link to workflow document. DockStore.org recommended. URL
subclass of: Sequencing
is part of: schema.biothings.io
display name: Structural Variant Workflow URL
required: sms:true

StructuralVariantWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: BRASS
range includes: GATK4
range includes: CNV
range includes: CNVkit
range includes: OtherStructuralVariantWorkflowType
range includes: None
display name: Structural Variant Workflow Type
required: sms:false

MicroarrayLevel1
type: Class
comment: Microarray Level 1 refers to the raw text table of probe level intensities
subclass of: Assay
is part of: schema.biothings.io
display name: Microarray Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANDataFileID
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: NucleicAcidSource
requires dependency: MicroarrayPlatformID
requires dependency: MicroarrayMolecule
requires dependency: MicroarrayLabel
requires dependency: MicroarrayValueDefinition
requires dependency: MicroarrayProtocolAuxiliaryFile

MicroarrayPlatformID
type: Class
comment: The NCBI GEO Microarray Platform ID that links to the table containing the array definition
subclass of: MicroarrayLevel1
is part of: schema.biothings.io
display name: Microarray Platform ID
required: sms:true
validation rules: regex match GPL\d+

MicroarrayMolecule
type: Class
comment: Microarray is measuring this kind of molecule
subclass of: MicroarrayLevel1
is part of: schema.biothings.io
range includes: DNA
range includes: RNA
display name: Microarray Molecule
required: sms:true

MicroarrayLabel
type: Class
comment: Microarray used this kind of label
subclass of: MicroarrayLevel1
is part of: schema.biothings.io
display name: Microarray Label
required: sms:true

MicroarrayValueDefinition
type: Class
comment: What the provided value signifies
subclass of: MicroarrayLevel1
is part of: schema.biothings.io
display name: Microarray Value Definition
required: sms:true

MicroarrayProtocolAuxiliaryFile
type: Class
comment: Auxiliary file describing the experimental protocols used, as described in the NCBI GEO microarray template, recorded as synapse ID (syn12345).
subclass of: MicroarrayLevel1
is part of: schema.biothings.io
display name: Microarray Protocol Auxiliary File
required: sms:true
validation rules: regex match syn\d+

MicroarrayLevel2
type: Class
comment: Microarray Level 2 provides a normalized matrix of values.
subclass of: Assay
is part of: schema.biothings.io
display name: Microarray Level 2
required: sms:false
requires component: MicroarrayLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: MicroarrayPlatformID
requires dependency: NormalizationMethod

NormalizationMethod
type: Class
comment: Description of Normalization Process
subclass of: RPPALevel2
is part of: schema.biothings.io
display name: Normalization Method
required: sms:false

ScATAC-seqLevel1
type: Class
comment: scATAC-seq files containing sequence read information, with or without alignment, as FASTQ or BAM files
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATAC-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: DissociationMethod
requires dependency: SingleNucleusBuffer
requires dependency: SingleCellIsolationMethod
requires dependency: TranspositionReaction
requires dependency: ScATACseqLibraryLayout
requires dependency: NucleusIdentifier
requires dependency: NucleiBarcodeLength
requires dependency: NucleiBarcodeRead
requires dependency: ScATACseqRead1
requires dependency: ScATACseqRead2
requires dependency: ScATACseqRead3
requires dependency: LibraryConstructionMethod
requires dependency: SequencingPlatform
requires dependency: ThresholdforMinimumPassingReads
requires dependency: TotalNumberofPassingNuclei
requires dependency: MedianFractionofReadsinPeaks
requires dependency: MedianFractionofReadsinAnnotatedcisDNAElements
requires dependency: MedianPassingReadPercentage
requires dependency: MedianPercentageofMitochondrialReadsperNucleus
requires dependency: TechnicalReplicateGroup
requires dependency: TotalReads
requires dependency: ProtocolLink

SingleNucleusBuffer
type: Class
comment: Nuclei isolation buffer
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
range includes: NIB
range includes: 10x
range includes: Omni
range includes: TST
display name: Single Nucleus Buffer
required: sms:true

TranspositionReaction
type: Class
comment: Name of the transposase, transposon sequences
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
range includes: Tn5
range includes: EZ-Tn5
range includes: Tn5-059
range includes: NexteraTn5
range includes: Diagenode-unloadedApex-Bio
range includes: Diagenode-loadedApex-Bio
range includes: In-House
display name: Transposition Reaction
required: sms:true

ScATACseqLibraryLayout
type: Class
comment: Sequencing read type
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
range includes: ScATACseqPairedEnd
display name: scATACseq Library Layout
required: sms:true

NucleusIdentifier
type: Class
comment: Unique nuclei barcode; added at transposition step. Determines which nucleus the reads originated from
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
range includes: NucleiBarcode
display name: Nucleus Identifier
required: sms:true

NucleiBarcodeLength
type: Class
comment: Nuclei Barcode Length
subclass of: ScATAC-seqLevel1
subclass of: NucleiBarcode
is part of: schema.biothings.io
display name: Nuclei Barcode Length
required: sms:true

NucleiBarcodeRead
type: Class
comment: Nuclei Barcode Read
subclass of: ScATAC-seqLevel1
subclass of: NucleiBarcode
is part of: schema.biothings.io
display name: Nuclei Barcode Read
required: sms:true

ScATACseqRead1
type: Class
comment: Read 1 content description
subclass of: ScATAC-seqLevel1
subclass of: ScATACseqPairedEnd
is part of: schema.biothings.io
range includes: CellBarcodeandDNAInsert
range includes: SampleIndexandDNAInsert
range includes: DNAInsert
range includes: SampleIndex
range includes: CellBarcode
display name: scATACseq Read1
required: sms:true

ScATACseqRead2
type: Class
comment: Read 2 content description
subclass of: ScATAC-seqLevel1
subclass of: ScATACseqPairedEnd
is part of: schema.biothings.io
range includes: CellBarcodeandDNAInsert
range includes: SampleIndexandDNAInsert
range includes: DNAInsert
range includes: SampleIndex
range includes: CellBarcode
display name: scATACseq Read2
required: sms:true

ScATACseqRead3
type: Class
comment: Read 3 content description
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandDNAInsert
range includes: SampleIndexandDNAInsert
range includes: DNAInsert
range includes: SampleIndex
range includes: CellBarcode
display name: scATACseq Read3
required: sms:false

ThresholdforMinimumPassingReads
type: Class
comment: Threshold for calling cells
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Threshold for Minimum Passing Reads
required: sms:true

TotalNumberofPassingNuclei
type: Class
comment: Number of nuclei sequenced
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Total Number of Passing Nuclei
required: sms:true

MedianFractionofReadsinPeaks
type: Class
comment: Median fraction of reads in peaks (FRIP)
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Median Fraction of Reads in Peaks
required: sms:true
requires dependency: PeaksCallingSoftware

MedianFractionofReadsinAnnotatedcisDNAElements
type: Class
comment: Median fraction of reads in annotated cis-DNA elements (FRIADE)
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Median Fraction of Reads in Annotated cis DNA Elements
required: sms:true
requires dependency: PeaksCallingSoftware

MedianPassingReadPercentage
type: Class
comment: Non-PCR duplicate nuclear genomic sequence reads not aligning to unanchored contigs out of total reads assigned to the nucleus barcode
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Median Passing Read Percentage
required: sms:true

MedianPercentageofMitochondrialReadsperNucleus
type: Class
comment: Contamination from mitochondrial sequences
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Median Percentage of Mitochondrial Reads per Nucleus
required: sms:true

ScATAC-seqLevel2
type: Class
comment: scATAC-seq files containing aligned sequence data, as a BAM file
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATAC-seq Level 2
required: sms:false
requires component: ScATAC-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowUrl
requires dependency: AlignmentWorkflowType
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: MeanCoverage
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: ProportionReadsMapped
requires dependency: MapQ30
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ShortReads
requires dependency: ProportionCoverage10x
requires dependency: ProportionCoverage30X
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: MedianPercentageofMitochondrialReadsperNucleus
requires dependency: Contamination
requires dependency: ContaminationError

MapQ30
type: Class
comment: Number of reads with Quality >= 30.
subclass of: ScATAC-seqLevel1
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: MapQ30
required: sms:false

ScATAC-seqLevel3
type: Class
comment: Processed data files containing peak information for cells
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATAC-seq Level 3
required: sms:false
requires component: ScATAC-seqLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: ScATAC-seqObjectID
requires dependency: NCountPeaks
requires dependency: NFeaturePeaks
requires dependency: TotalRead-Pairs
requires dependency: DuplicateRead-Pairs
requires dependency: ChimericRead-Pairs
requires dependency: UnmappedRead-Pairs
requires dependency: LowMapQ
requires dependency: MitochondrialRead-Pairs
requires dependency: PassedFilters
requires dependency: TSSFragments
requires dependency: DNaseSensitiveRegionFragments
requires dependency: EnhancerRegionFragments
requires dependency: PromoterRegionFragments
requires dependency: OnTargetFragments
requires dependency: BlacklistRegionFragments
requires dependency: PeakRegionFragments
requires dependency: PeakRegionCutsites
requires dependency: NucleosomeSignal
requires dependency: NucleosomePercentile
requires dependency: TSSEnrichment
requires dependency: TSSPercentile
requires dependency: PctReadsinPeaks
requires dependency: BlacklistRatio
requires dependency: SeuratClusters
requires dependency: NCountRNA
requires dependency: NFeatureRNA
requires dependency: MACS2Seqnames
requires dependency: MACS2Start
requires dependency: MACS2End
requires dependency: MACS2Width
requires dependency: MACS2Strand
requires dependency: MACS2Name
requires dependency: MACS2Score
requires dependency: MACS2FoldChange
requires dependency: MACS2NegLog10pvalueSummit
requires dependency: MACS2NegLog10qvalueSummit
requires dependency: MACS2RelativeSummitPosition

ScATAC-seqObjectID
type: Class
comment: Orig.Ident or scATAC-seq Object ID
subclass of: ScATAC-seqLevel3
is part of: schema.biothings.io
display name: scATAC-seq Object ID
required: sms:false

NCountPeaks
type: Class
comment: Total number of fragments in peaks
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: nCount Peaks
required: sms:false

NFeaturePeaks
type: Class
comment: Number of peaks with at least one read
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: nFeature Peaks
required: sms:false

TotalRead-Pairs
type: Class
comment: Total read-pairs
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Total Read-Pairs
required: sms:false

DuplicateRead-Pairs
type: Class
comment: Number of duplicate read-pairs
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Duplicate Read-Pairs
required: sms:false

ChimericRead-Pairs
type: Class
comment: Number of chimerically mapped read-pairs
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Chimeric Read-Pairs
required: sms:false

UnmappedRead-Pairs
type: Class
comment: Number of read-pairs with at least one end not mapped
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Unmapped Read-Pairs
required: sms:false

LowMapQ
type: Class
comment: Number of read-pairs with <30 mapq on at least one end
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: LowMapQ
required: sms:false

MitochondrialRead-Pairs
type: Class
comment: Number of read-pairs mapping to mitochondria and non-nuclear contigs
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Mitochondrial Read-Pairs
required: sms:false

PassedFilters
type: Class
comment: Number of non-duplicate, usable read-pairs i.e. fragments
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Passed Filters
required: sms:false

TSSFragments
type: Class
comment: Number of fragments overlapping with TSS regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: TSS Fragments
required: sms:false

DNaseSensitiveRegionFragments
type: Class
comment: Number of fragments overlapping with DNase sensitive regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: DNase Sensitive Region Fragments
required: sms:false

EnhancerRegionFragments
type: Class
comment: Number of fragments overlapping enhancer regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Enhancer Region Fragments
required: sms:false

PromoterRegionFragments
type: Class
comment: Number of fragments overlapping promoter regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Promoter Region Fragments
required: sms:false

OnTargetFragments
type: Class
comment: Number of fragments overlapping any of TSS, enhancer, promoter and DNase hypersensitivity sites (counted with multiplicity)
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: On Target Fragments
required: sms:false

BlacklistRegionFragments
type: Class
comment: Number of fragments overlapping blacklisted regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Blacklist Region Fragments
required: sms:false

PeakRegionFragments
type: Class
comment: Number of fragments overlapping peaks
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Peak Region Fragments
required: sms:false

PeakRegionCutsites
type: Class
comment: Number of ends of fragments in peak regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Peak Region Cutsites
required: sms:false

NucleosomeSignal
type: Class
comment: Nucleosome signal score (strength of the nucleosome signal per cell, computed as the ratio of fragments between 147 bp and 294 bp (mononucleosome) to fragments < 147 bp (nucleosome-free))
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Nucleosome Signal
required: sms:false

NucleosomePercentile
type: Class
comment: Percentile rank of nucleosome score
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Nucleosome Percentile
required: sms:false

TSSEnrichment
type: Class
comment: Transcription start site (TSS) enrichment score
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: TSS Enrichment
required: sms:false

TSSPercentile
type: Class
comment: Percentile rank of TSS score
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: TSS Percentile
required: sms:false

PctReadsinPeaks
type: Class
comment: Percentage of reads in peaks
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Pct Reads in Peaks
required: sms:false

BlacklistRatio
type: Class
comment: Ratio of reads in blacklist regions
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Blacklist Ratio
required: sms:false

SeuratClusters
type: Class
comment: Clusters of cells by a shared nearest neighbor (SNN) modularity optimization based clustering algorithm
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: Seurat Clusters
required: sms:false

NCountRNA
type: Class
comment: Total number of fragments in genes
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: nCount RNA
required: sms:false

NFeatureRNA
type: Class
comment: Number of genes detected in cell
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: nFeature RNA
required: sms:false

MACS2Seqnames
type: Class
comment: Chromosome id
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Seqnames
required: sms:false

MACS2Start
type: Class
comment: Genomic starting position in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Start
required: sms:false

MACS2End
type: Class
comment: Genomic ending position in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 End
required: sms:false

MACS2Width
type: Class
comment: Width of the peak in bases in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Width
required: sms:false

MACS2Strand
type: Class
comment: DNA stand aligned with in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Strand
required: sms:false

MACS2Name
type: Class
comment: Name of the peak in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Name
required: sms:false

MACS2Score
type: Class
comment: Peak score (proportional to q-value) in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Score
required: sms:false

MACS2FoldChange
type: Class
comment: Fold enrichment for this peak summit against random Poisson distribution with local lambda in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Fold Change
required: sms:false

MACS2NegLog10pvalueSummit
type: Class
comment: Negative log10 p-value for the peak summit in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Neg Log10 pvalue Summit
required: sms:false

MACS2NegLog10qvalueSummit
type: Class
comment: Negative log10 q-value for the peak summit in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Neg Log10 qvalue Summit
required: sms:false

MACS2RelativeSummitPosition
type: Class
comment: Position of the peak summit related to the start position in MACS2
subclass of: ScATAC-seqLevel2
is part of: schema.biothings.io
display name: MACS2 Relative Summit Position
required: sms:false

ScmC-seqLevel1
type: Class
comment: Files contain raw scmC-seq data.
subclass of: Sequencing
is part of: schema.biothings.io
display name: scmC-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: ScmCseqRead1
requires dependency: ScmCseqRead2
requires dependency: ScmCseqRead3
requires dependency: SingleCellIsolationMethod
requires dependency: SingleNucleusBuffer
requires dependency: SingleNucleusCapture
requires dependency: BisulfiteConversion
requires dependency: LibraryLayout
requires dependency: NucleusIdentifier
requires dependency: SequencingPlatform
requires dependency: TechnicalReplicateGroup
requires dependency: MedianFractionofReadsinPeaks
requires dependency: MedianPassingReadPercentage
requires dependency: PeaksCallingSoftware
requires dependency: MedianPercentageofMitochondrialReadsperNucleus
requires dependency: ThresholdforMinimumPassingReads
requires dependency: TotalNumberofPassingNuclei
requires dependency: TotalReads

ScmCseqRead1
type: Class
comment: Read 1 content description
subclass of: ScmC-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandUMI
range includes: CDNA
display name: scmCseq Read1
required: sms:true

ScmCseqRead2
type: Class
comment: Read 2 content description
subclass of: ScmC-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandUMI
range includes: CDNA
display name: scmCseq Read2
required: sms:true

ScmCseqRead3
type: Class
comment: Read 3 content description
subclass of: ScmC-seqLevel1
is part of: schema.biothings.io
range includes: CellBarcodeandUMI
range includes: CDNA
display name: scmCseq Read3
required: sms:true

SingleNucleusCapture
type: Class
comment: Nuclei isolation method
subclass of: ScmC-seqLevel1
is part of: schema.biothings.io
range includes: Plates
range includes: 10x
range includes: Droplet
display name: Single Nucleus Capture
required: sms:false

BisulfiteConversion
type: Class
comment: Name of the kit used in bisulfite conversion.
subclass of: BulkMethylation-seqLevel1
is part of: schema.biothings.io
range includes: ZimoEZDNAMethylationKit
range includes: ZimoEZ-96DNAMethylationShallowKit
range includes: ZimoEZ-96DNAMethylationDeepKit
range includes: NEBNextEnzymaticMethyl-seqKit
range includes: AgilentSureSelectXTMethyl-Seq
display name: Bisulfite Conversion
required: sms:true

PeaksCallingSoftware
type: Class
comment: Generic name of peaks calling tool
subclass of: ScATAC-seqLevel1
is part of: schema.biothings.io
display name: Peaks Calling Software
required: sms:true

ScmC-seqLevel2
type: Class
comment: Files contain scmC-seq files containing aligned sequence data, as a BAM file.
subclass of: Sequencing
is part of: schema.biothings.io
display name: scmC-seq Level 2
required: sms:false
requires component: ScmC-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowUrl
requires dependency: AlignmentWorkflowType
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: Contamination
requires dependency: ContaminationError
requires dependency: MeanCoverage
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ProportionReadsMapped
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: ShortReads

ScATAC-seqLevel4
type: Class
comment: Data represents the relationships between cells derived from Level 3 expression data and shown as tSNE or UMAP coordinates per cell, plus all other cell-specific meta information (e.g., cell type)
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATAC-seq Level 4
required: sms:false
requires component: ScATAC-seqLevel3
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: ScATACseqWorkflowType
requires dependency: ScATACseqWorkflowParametersDescription
requires dependency: WorkflowVersion
requires dependency: WorkflowLink

ScATACseqWorkflowType
type: Class
comment: Generic name for the workflow used to analyze a data set.
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATACseq Workflow Type
required: sms:true

ScATACseqWorkflowParametersDescription
type: Class
comment: Parameters used to run the scATAC-seq workflow.
subclass of: Sequencing
is part of: schema.biothings.io
display name: scATACseq Workflow Parameters Description
required: sms:true

ScDNA-seqLevel1
type: Class
comment: Single-cell DNA-seq
subclass of: Sequencing
is part of: schema.biothings.io
display name: scDNA-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: SequencingBatchID
requires dependency: LibraryLayout
requires dependency: NucleicAcidSource
requires dependency: LibrarySelectionMethod
requires dependency: ReadLength
requires dependency: LibraryPreparationKitName
requires dependency: LibraryPreparationKitVendor
requires dependency: LibraryPreparationKitVersion
requires dependency: AdapterName
requires dependency: AdapterSequence
requires dependency: BaseCallerName
requires dependency: BaseCallerVersion
requires dependency: FlowCellBarcode
requires dependency: FragmentMaximumLength
requires dependency: FragmentMeanLength
requires dependency: FragmentMinimumLength
requires dependency: FragmentStandardDeviationLength
requires dependency: LaneNumber
requires dependency: LibraryStrand
requires dependency: MultiplexBarcode
requires dependency: SizeSelectionRange
requires dependency: TargetDepth
requires dependency: ToTrimAdapterSequence
requires dependency: AdapterContent
requires dependency: BasicStatistics
requires dependency: Encoding
requires dependency: KmerContent
requires dependency: OverrepresentedSequences
requires dependency: PerBaseNContent
requires dependency: PerBaseSequenceContent
requires dependency: PerBaseSequenceQuality
requires dependency: PerSequenceGCContent
requires dependency: PerSequenceQualityScore
requires dependency: PerTileSequenceQuality
requires dependency: PercentGCContent
requires dependency: SequenceDuplicationLevels
requires dependency: SequenceLengthDistribution
requires dependency: TotalReads
requires dependency: QCWorkflowType
requires dependency: QCWorkflowVersion
requires dependency: QCWorkflowLink

ScDNA-seqLevel2
type: Class
comment: Alignment workflows downstream of scDNA-seq Level 1
subclass of: Sequencing
is part of: schema.biothings.io
display name: scDNA-seq Level 2
required: sms:false
requires component: ScDNA-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowUrl
requires dependency: AlignmentWorkflowType
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: MeanCoverage
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: ProportionReadsMapped
requires dependency: MapQ30
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ShortReads
requires dependency: ProportionCoverage10x
requires dependency: ProportionCoverage30X
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: ProportionMitochondrialReads
requires dependency: Contamination
requires dependency: ContaminationError

ProportionMitochondrialReads
type: Class
comment: Proportion of reads mapping to mitochondria.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Proportion Mitochondrial Reads
required: sms:false

MultiplexedCITE-seqLevel1
type: Class
comment: Raw sequencing files for the multiplexed CITE-seq assay
subclass of: Sequencing
is part of: schema.biothings.io
display name: Multiplexed CITE-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: CryopreservedCellsinSample
requires dependency: SingleCellIsolationMethod
requires dependency: DissociationMethod
requires dependency: LibraryConstructionMethod
requires dependency: ReadIndicator
requires dependency: Read1
requires dependency: Read2
requires dependency: EndBias
requires dependency: ReverseTranscriptionPrimer
requires dependency: SpikeIn
requires dependency: SpikeInConcentration
requires dependency: SequencingPlatform
requires dependency: TotalNumberofInputCells
requires dependency: InputCellsandNuclei
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SingleCellDissociationDaysfromIndex
requires dependency: SequencingLibraryConstructionDaysfromIndex
requires dependency: NucleicAcidCaptureDaysfromIndex
requires dependency: ProtocolLink
requires dependency: TechnicalReplicateGroup
requires dependency: EmptyWellBarcode
requires dependency: WellIndex
requires dependency: FeatureReferenceId
requires dependency: AssociatedmRNALibraryDataFileID
requires dependency: SingleCellBarcodeMethodApplied
requires dependency: FeatureBarcodeLibraryType
requires dependency: BarcodeFolderSynapseID
requires dependency: BarcodeFolderFileList

SpikeInConcentration
type: Class
comment: The final concentration or dilution (for commercial sets) of the spike in mix [PMID:21816910]
subclass of: ERCC
is part of: schema.biothings.io
display name: Spike In Concentration
required: sms:true

EmptyWellBarcode
type: Class
comment: Unique cell barcode assigned to empty cells used as controls in CEL-seq2 assays.
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Empty Well Barcode
required: sms:true

WellIndex
type: Class
comment: Indicate if protein expression (EPCAM/CD45) positive/negative data is available for each cell in CEL-seq2 assays
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Well Index
required: sms:false

FeatureReferenceId
type: Class
comment: Unique ID for this feature. Must not contain whitespace, quote or comma characters. Each ID must be unique and must not collide with a gene identifier from the transcriptome [https://support.10xgenomics.com/single-cell-gene-expression/software/pipelines/latest/using/feature-bc-analysis#feature-ref]
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Feature Reference Id
required: sms:true

AssociatedmRNALibraryDataFileID
type: Class
comment: Sample Level HTAN Data File ID for the associated level - HTAN ID of this file HTAN ID SOP (eg HTANx_yyy_zzz)
subclass of: MultiplexedCITE-seqLevel1
is part of: schema.biothings.io
display name: Associated mRNA Library Data File ID
required: sms:true

SingleCellBarcodeMethodApplied
type: Class
comment: The method by which cells are multiplex or labeled with cell surface markers or probes
subclass of: MultiplexedCITE-seqLevel1
is part of: schema.biothings.io
range includes: Cite-seqcustompanel
range includes: BiolegendTotalseqACustom
range includes: BiolegendTotalseqBCustom
range includes: BiolegendTotalseqCCustom
range includes: BiolegendTotalseqAHuman
range includes: UniversalcocktailV1.0
range includes: Cell
range includes: Hashtag-multiplex
range includes: NuclearHashtag-multiplex
range includes: Other
display name: Single Cell Barcode Method Applied
required: sms:true

FeatureBarcodeLibraryType
type: Class
comment: The library construction methods for the feature barcode library
subclass of: MultiplexedCITE-seqLevel1
is part of: schema.biothings.io
range includes: hashing
range includes: 10xTCR
range includes: 10xBCR
display name: Feature Barcode Library Type
required: sms:true

BarcodeFolderSynapseID
type: Class
comment: Synapse ID of the folder containing the barcode lists
subclass of: MultiplexedCITE-seqLevel1
is part of: schema.biothings.io
display name: Barcode Folder Synapse ID
required: sms:true

BarcodeFolderFileList
type: Class
comment: A comma separated list of filenames in the gzipped folder detailing what barcodes are specific to demultiplexing samples versus providing surface protein data
subclass of: MultiplexedCITE-seqLevel1
is part of: schema.biothings.io
display name: Barcode Folder File List
required: sms:true

MultiplexedCITE-seqLevel2
type: Class
comment: Alignment workflows downstream of Multiplexed CITE-seq Level 1
subclass of: Sequencing
is part of: schema.biothings.io
display name: Multiplexed CITE-seq Level 2
required: sms:false
requires component: MultiplexedCITE-seqLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AssociatedmRNALibraryDataFileID
requires dependency: ScRNAseqWorkflowType
requires dependency: WorkflowVersion
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowLink
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: GenomeAnnotationURL
requires dependency: Checksum
requires dependency: WhitelistCellBarcodeFileLink
requires dependency: CellBarcodeTag
requires dependency: UMITag
requires dependency: AppliedHardTrimming

MultiplexedCITE-seqLevel3
type: Class
comment: Gene and Isoform expression files
subclass of: Sequencing
is part of: schema.biothings.io
display name: Multiplexed CITE-seq Level 3
required: sms:false
requires component: ScRNA-seqLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: AssociatedmRNALibraryDataFileID
requires dependency: DataCategory
requires dependency: MatrixType
requires dependency: LinkedMatrices
requires dependency: CellMedianNumberReads
requires dependency: CellMedianNumberGenes
requires dependency: CellTotal
requires dependency: ScRNAseqWorkflowType
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowLink
requires dependency: WorkflowVersion

MultiplexedCITE-seqLevel4
type: Class
comment: Data represents the relationships between cells derived from Level 3 expression data and shown as tSNE or UMAP coordinates per cell, plus all other cell-specific meta information (e.g., cell type)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Multiplexed CITE-seq Level 4
required: sms:false
requires component: MultiplexedCITE-seqLevel3
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: AssociatedmRNALibraryDataFileID
requires dependency: ScRNAseqWorkflowType
requires dependency: ScRNAseqWorkflowParametersDescription
requires dependency: WorkflowVersion
requires dependency: WorkflowLink

BulkMethylation-seqLevel1
type: Class
comment: Raw data for bulk methylation sequencing, such as FASTQs and unaligned BAMs
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk Methylation-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: NucleicAcidSource
requires dependency: BisulfiteConversion
requires dependency: SequencingPlatform
requires dependency: ReplicateType
requires dependency: BulkMethylationAssayType
requires dependency: TotalDNAInput

ReplicateType
type: Class
comment: A common term for all files belonging to the same sample. We suggest using a stable sample accession from a biosample archive like BioSamples.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Technicalreplicate
range includes: Biologicalreplicate
range includes: NotApplicable
display name: Replicate Type
required: sms:true

BulkMethylationAssayType
type: Class
comment: Assay types normally determine genomic coverage
subclass of: BulkMethylation-seqLevel1
is part of: schema.biothings.io
range includes: Wholegenome
range includes: TargetedGenome
range includes: BeadchipArray
display name: Bulk Methylation Assay Type
required: sms:true
requires dependency: TargetedGenome
requires dependency: BeadchipArray

TotalDNAInput
type: Class
comment: Overall number of reads for a given sample in digits (microgram, nanogram).
subclass of: BulkMethylationAssayType
is part of: schema.biothings.io
display name: Total DNA Input
required: sms:false

BulkMethylation-seqLevel2
type: Class
comment: Aligned primary data for bulk methylation sequencing, such as gene expression matrix files, VCFs, etc.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk Methylation-seq Level 2
required: sms:false
requires component: BulkMethylation-seqLevel1
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AlignmentWorkflowUrl
requires dependency: Trimmer
requires dependency: BulkMethylationGenomicReference
requires dependency: GenomicReferenceURL
requires dependency: IndexFileName
requires dependency: AlignmentWorkflowType
requires dependency: DuplicateRemovalSoftware
requires dependency: MeanCoverage
requires dependency: LibraryLayout
requires dependency: AverageBaseQuality
requires dependency: AverageInsertSize
requires dependency: AverageReadLength
requires dependency: Contamination
requires dependency: ContaminationError
requires dependency: PairsOnDiffCHR
requires dependency: TotalReads
requires dependency: TotalUniquelyMapped
requires dependency: TotalUnmappedreads
requires dependency: ProportionReadsDuplicated
requires dependency: ProportionReadsMapped
requires dependency: ProportionTargetsNoCoverage
requires dependency: ProportionBaseMismatch
requires dependency: ShortReads
requires dependency: ProportionofMinimumCpGCoverage10X
requires dependency: ProportionCoverage30X

Trimmer
type: Class
comment: Software used for trimming
subclass of: BulkMethylation-seqLevel2
is part of: schema.biothings.io
range includes: FASTXtoolkit
range includes: SolexaQA
range includes: Btrim
range includes: Cutadapt
range includes: Kraken
range includes: PRINSEQ
range includes: Adapterremoval
range includes: TrimGalore!
range includes: ConDeTri
range includes: ERNE-FILTER
range includes: Trimmo-matic
display name: Trimmer
required: sms:true

BulkMethylationGenomicReference
type: Class
comment: The human genome reference used in the alignment of reads
subclass of: BulkMethylation-seqLevel2
is part of: schema.biothings.io
range includes: HG19
range includes: HG38
range includes: T2TCHM13
display name: Bulk Methylation Genomic Reference
required: sms:true

DuplicateRemovalSoftware
type: Class
comment: Software used for remove duplicate reads
subclass of: BulkMethylation-seqLevel2
is part of: schema.biothings.io
range includes: Samtoolssort
range includes: PicardMarkDuplicates
display name: Duplicate Removal Software
required: sms:true

ProportionofMinimumCpGCoverage10X
type: Class
comment: Proportion of all reference bases for whole genome sequencing, or targeted sequencing, that achieves 10X or greater coverage per CpG.
subclass of: BulkMethylation-seqLevel2
is part of: schema.biothings.io
display name: Proportion of Minimum CpG Coverage 10X
required: sms:false

BulkMethylation-seqLevel3
type: Class
comment: Sample level summary data for bulk methylation sequencing, such as t-SNE plot coordinates, etc.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Bulk Methylation-seq Level 3
required: sms:false
requires component: BulkMethylation-seqLevel2
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: DMCCallingTool
requires dependency: DMCCallingWorkflowURL
requires dependency: DMRCallingTool
requires dependency: DMRCallingWorkflowURL
requires dependency: PUC19methylationratio
requires dependency: Lambdamethylationratio
requires dependency: DMCdatafileformat
requires dependency: DMRdatafileFormat

DMCCallingTool
type: Class
comment: Software used for calling differentially methylated CpG (DMC) and differentially methylated region (DMR)
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
range includes: MethylKit
range includes: BSmooth
range includes: BiSeq
range includes: MethylSig
range includes: DSS
range includes: MOABS
range includes: DSS-single
range includes: Metilene
range includes: MACAU
range includes: MethylDackel
display name: DMC Calling Tool
required: sms:true

DMCCallingWorkflowURL
type: Class
comment: Generic name for the workflow used to analyze a data set
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
display name: DMC Calling Workflow URL
required: sms:true
validation rules: url

DMRCallingTool
type: Class
comment: Software used for calling differentially methylated CpG (DMC) and differentially methylated region (DMR)
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
range includes: MethylKit
range includes: BSmooth
range includes: BiSeq
range includes: MethylSig
range includes: DSS
range includes: MOABS
range includes: DSS-single
range includes: Metilene
range includes: MACAU
display name: DMR Calling Tool
required: sms:true

DMRCallingWorkflowURL
type: Class
comment: Generic name for the workflow used to analyze a data set
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
display name: DMR Calling Workflow URL
required: sms:true
validation rules: url

PUC19methylationratio
type: Class
comment: Methylation ratio of mostly methylated pUC19 control, as a percentage
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
display name: pUC19 methylation ratio
required: sms:true

Lambdamethylationratio
type: Class
comment: Methylation ratio of mostly unmethylated lambda control, as a percentage
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
display name: Lambda methylation ratio
required: sms:true

DMCdatafileformat
type: Class
comment: Format of the data files
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
range includes: BED
range includes: BedGraph
display name: DMC data file format
required: sms:true

DMRdatafileFormat
type: Class
comment: Format of the data files.
subclass of: BulkMethylation-seqLevel3
is part of: schema.biothings.io
range includes: BED
range includes: BedGraph
display name: DMR data file Format
required: sms:true

ImagingLevel1
type: Class
comment: Raw imaging data
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: ImagingAssayType
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: CommitSHA
requires dependency: Pre-processingCompleted
requires dependency: Pre-processingRequired
requires dependency: Comment

ImagingAssayType
type: Class
comment: Type of imaging assay
subclass of: Imaging
is part of: schema.biothings.io
range includes: H&E
range includes: CyCIF
range includes: T-CyCIF
range includes: IHC
range includes: MIHC
range includes: MxIF
range includes: SABER
range includes: IMC
range includes: CODEX
range includes: GeoMX-DSP
range includes: MIBI
range includes: MERFISH
range includes: ExSeq
range includes: RareCyteOrion
range includes: NotApplicable
display name: Imaging Assay Type
required: sms:true

SoftwareandVersion
type: Class
comment: Name of software used to generate expression values. String
subclass of: Sequencing
is part of: schema.biothings.io
display name: Software and Version
required: sms:true

CommitSHA
type: Class
comment: Short SHA for software version [8 hexadecimal characters (for github), comma separated if multiple]
subclass of: Imaging
is part of: schema.biothings.io
display name: Commit SHA
required: sms:false

Pre-processingCompleted
type: Class
comment: Pre-processing steps completed to convert level 1 raw data to a single level 2 image
subclass of: Imaging
is part of: schema.biothings.io
range includes: Illuminationcorrection
range includes: TileStitching
range includes: CycleRegistration
range includes: TMAde-arraying
range includes: None
range includes: Other
display name: Pre-processing Completed
required: sms:true

Pre-processingRequired
type: Class
comment: Pre-processing steps required to convert level 1 raw data to a single level 2 image
subclass of: Imaging
is part of: schema.biothings.io
range includes: Illuminationcorrection
range includes: TileStitching
range includes: CycleRegistration
range includes: TMAde-arraying
range includes: None
range includes: Other
display name: Pre-processing Required
required: sms:true

Comment
type: Class
comment: Free text field (generally for QC comment)
subclass of: Imaging
is part of: schema.biothings.io
display name: Comment
required: sms:false

ImagingLevel2
type: Class
comment: Raw and pre-processed image data
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 2
required: sms:false
requires component: ImagingLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: ChannelMetadataFilename
requires dependency: ImagingAssayType
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: Microscope
requires dependency: Objective
requires dependency: NominalMagnification
requires dependency: LensNA
requires dependency: WorkingDistance
requires dependency: WorkingDistanceUnit
requires dependency: Immersion
requires dependency: Pyramid
requires dependency: Zstack
requires dependency: Tseries
requires dependency: PassedQC
requires dependency: Comment
requires dependency: FOVnumber
requires dependency: FOVX
requires dependency: FOVXUnit
requires dependency: FOVY
requires dependency: FOVYUnit
requires dependency: FrameAveraging
requires dependency: ImageID
requires dependency: DimensionOrder
requires dependency: PhysicalSizeX
requires dependency: PhysicalSizeXUnit
requires dependency: PhysicalSizeY
requires dependency: PhysicalSizeYUnit
requires dependency: PhysicalSizeZ
requires dependency: PhysicalSizeZUnit
requires dependency: PixelsBigEndian
requires dependency: PlaneCount
requires dependency: SizeC
requires dependency: SizeT
requires dependency: SizeX
requires dependency: SizeY
requires dependency: SizeZ
requires dependency: PixelType
requires dependency: MERFISHPositionsFile
requires dependency: MERFISHCodebookFile

ChannelMetadataFilename
type: Class
comment: Full path within Synapse project of uploaded companion CSV file containing channel-level metadata details
subclass of: ImagingLevel2
is part of: schema.biothings.io
display name: Channel Metadata Filename
required: sms:true

Microscope
type: Class
comment: Microscope type (manufacturer, model, etc) used for this experiment
subclass of: Imaging
is part of: schema.biothings.io
display name: Microscope
required: sms:true

Objective
type: Class
comment: Objective
subclass of: Imaging
is part of: schema.biothings.io
display name: Objective
required: sms:false

NominalMagnification
type: Class
comment: The magnification of the lens as specified by the manufacturer - i.e. '60' is a 60X lens. floating point value > 1(no units)
subclass of: Imaging
is part of: schema.biothings.io
display name: NominalMagnification
required: sms:true
validation rules: num

LensNA
type: Class
comment: The numerical aperture of the lens. Floating point value > 0.
subclass of: Imaging
is part of: schema.biothings.io
display name: LensNA
required: sms:false
validation rules: num

WorkingDistance
type: Class
comment: The working distance of the lens, expressed as a floating point number. Floating point > 0.
subclass of: Imaging
is part of: schema.biothings.io
display name: WorkingDistance
required: sms:false
requires dependency: WorkingDistanceUnit

WorkingDistanceUnit
type: Class
comment: The units of the working distance. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: WorkingDistanceUnit
required: sms:false

Immersion
type: Class
comment: Immersion medium
subclass of: Imaging
is part of: schema.biothings.io
range includes: Air
range includes: Oil
range includes: Water
range includes: Other
display name: Immersion
required: sms:false

Pyramid
type: Class
comment: Does data file contain pyramid of images
subclass of: Imaging
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Pyramid
required: sms:true

Zstack
type: Class
comment: Does data file contain a Z-stack of images
subclass of: Imaging
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Zstack
required: sms:true

Tseries
type: Class
comment: Does data file contain a time-series of images
subclass of: Imaging
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Tseries
required: sms:true

PassedQC
type: Class
comment: Did all channels pass QC (if not add free text Comment)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Yes
range includes: No-ChannelsQC
display name: Passed QC
required: sms:true

FOVnumber
type: Class
comment: Index of FOV (as it pertains to its sequence order). Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: FOV number
required: sms:false
validation rules: num

FOVX
type: Class
comment: Field of view X dimension. Floating point
subclass of: Imaging
is part of: schema.biothings.io
display name: FOVX
required: sms:false
requires dependency: FOVXUnit
validation rules: num

FOVXUnit
type: Class
comment: Field of view X dimension units. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: FOVXUnit
required: sms:false

FOVY
type: Class
comment: Field of view Y dimension. Floating point value
subclass of: Imaging
is part of: schema.biothings.io
display name: FOVY
required: sms:false
requires dependency: FOVYUnit
validation rules: num

FOVYUnit
type: Class
comment: Field of view Y dimension units. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: FOVYUnit
required: sms:false

FrameAveraging
type: Class
comment: Number of frames averaged together (if no averaging, set to 1). Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: Frame Averaging
required: sms:false

ImageID
type: Class
comment: Unique internal image identifier. eg "Image:0". (To be extracted from OME-XML)
subclass of: Imaging
is part of: schema.biothings.io
display name: Image ID
required: sms:true

DimensionOrder
type: Class
comment: The order in which the individual planes of data are interleaved.
subclass of: Imaging
is part of: schema.biothings.io
range includes: XYZCT
range includes: XYZTC
range includes: XYCTZ
range includes: XYCZT
range includes: XYTZC
range includes: ZYX
display name: DimensionOrder
required: sms:true

PhysicalSizeX
type: Class
comment: Physical size (X-dimension) of a pixel. Units are set by PhysicalSizeXUnit. Floating point value > 0.
subclass of: Imaging
is part of: schema.biothings.io
display name: PhysicalSizeX
required: sms:true
requires dependency: PhysicalSizeXUnit

PhysicalSizeXUnit
type: Class
comment: The units of the physical size of a pixel. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: PhysicalSizeXUnit
required: sms:true

PhysicalSizeY
type: Class
comment: Physical size (Y-dimension) of a pixel. Units are set by PhysicalSizeYUnit. Floating point value > 0.
subclass of: Imaging
is part of: schema.biothings.io
display name: PhysicalSizeY
required: sms:true
requires dependency: PhysicalSizeYUnit

PhysicalSizeYUnit
type: Class
comment: The units of the physical size of a pixel. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: PhysicalSizeYUnit
required: sms:true

PhysicalSizeZ
type: Class
comment: Physical size (Z-dimension) of a pixel. Units are set by PhysicalSizeZUnit. Floating point value > 0.
subclass of: Imaging
is part of: schema.biothings.io
display name: PhysicalSizeZ
required: sms:true
requires dependency: PhysicalSizeZUnit

PhysicalSizeZUnit
type: Class
comment: The units of the physical size of a pixel. See OME enumeration of allowed values for the UnitsLength attribute -- default: microns (um)
subclass of: Imaging
is part of: schema.biothings.io
range includes: Cm
range includes: Mm
range includes: Μm
range includes: Nm
range includes: Å
display name: PhysicalSizeZUnit
required: sms:true

PixelsBigEndian
type: Class
comment: Boolean (True/False)
subclass of: Imaging
is part of: schema.biothings.io
range includes: True
range includes: False
display name: Pixels BigEndian
required: sms:true

PlaneCount
type: Class
comment: Number of Z-planes (not to be confused with downsampled "pyramid"). Integer >=1
subclass of: Imaging
is part of: schema.biothings.io
display name: PlaneCount
required: sms:true

SizeC
type: Class
comment: Number of channels. Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: SizeC
required: sms:true
validation rules: int

SizeT
type: Class
comment: Number of time points. Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: SizeT
required: sms:true
validation rules: int

SizeX
type: Class
comment: Size of image: X dimension (in pixels). Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: SizeX
required: sms:true
validation rules: int

SizeY
type: Class
comment: Size of image: Y dimension (in pixels). Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: SizeY
required: sms:true
validation rules: int

SizeZ
type: Class
comment: Size of image: Z dimension (in pixels). Integer >= 1
subclass of: Imaging
is part of: schema.biothings.io
display name: SizeZ
required: sms:true
validation rules: int

PixelType
type: Class
comment: Data type for each pixel value. E.g. "uint16"
subclass of: Imaging
is part of: schema.biothings.io
range includes: Int8
range includes: Int16
range includes: Int32
range includes: Uint8
range includes: Uint16
range includes: Uint32
range includes: Float
range includes: Double
range includes: Bit
display name: PixelType
required: sms:true

MERFISHPositionsFile
type: Class
comment: The positions file is an auxiliary MERFISH file that describes the location of bead positions in the assay.
subclass of: Assay
is part of: schema.biothings.io
display name: MERFISH Positions File
required: sms:false

MERFISHCodebookFile
type: Class
comment: The codebook is an auxiliary MERFISH file that describes how each grouping of bits is converted to a gene name.
subclass of: Assay
is part of: schema.biothings.io
display name: MERFISH Codebook File
required: sms:false

ImagingLevel3Segmentation
type: Class
comment: Object segmentations
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 3 Segmentation
required: sms:false
requires component: ImagingLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: ImagingSegmentationDataType
requires dependency: Parameterfile
requires dependency: SoftwareandVersion
requires dependency: CommitSHA
requires dependency: ImagingObjectClass
requires dependency: NumberofObjects

ImagingSegmentationDataType
type: Class
comment: Specifies how the segmentation is stored
subclass of: Imaging
is part of: schema.biothings.io
range includes: Mask
range includes: Outline
range includes: Polygon
range includes: ProbabilityMap
range includes: Point
display name: Imaging Segmentation Data Type
required: sms:true

Parameterfile
type: Class
comment: Path in Syanpse to a text file listing algorithm version numbers and relevant parameters needed to reproduce the analysis
subclass of: Imaging
is part of: schema.biothings.io
display name: Parameter file
required: sms:false

ImagingObjectClass
type: Class
comment: Defines the structure that the mask delineates
subclass of: Imaging
is part of: schema.biothings.io
range includes: Nucleus
range includes: Cytoplasm
range includes: Plasmamembrane
range includes: Wholecell
range includes: Spot
range includes: ImagingObjectClassOther
display name: Imaging Object Class
required: sms:true
validation rules: list like

NumberofObjects
type: Class
comment: The number of objects (eg cells) described
subclass of: Imaging
is part of: schema.biothings.io
display name: Number of Objects
required: sms:true
validation rules: int

ImagingLevel3Image
type: Class
comment: Quality controlled imaging data
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 3 Image
required: sms:false
requires component: ImagingLevel3Channels
requires component: ImagingLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANParentChannelMetadataID
requires dependency: HTANDataFileID
requires dependency: ImagingAssayType
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: Microscope
requires dependency: Objective
requires dependency: NominalMagnification
requires dependency: LensNA
requires dependency: WorkingDistance
requires dependency: Immersion
requires dependency: Pyramid
requires dependency: Zstack
requires dependency: Tseries
requires dependency: PassedQC
requires dependency: Comment
requires dependency: FOVnumber
requires dependency: FOVX
requires dependency: FOVY
requires dependency: FrameAveraging

HTANParentChannelMetadataID
type: Class
comment: HTAN ID for a level 3 channels table.
subclass of: ImagingLevel4
is part of: schema.biothings.io
display name: HTAN Parent Channel Metadata ID
required: sms:true

ImagingLevel3Channels
type: Class
comment: Channel-level Metadata Attributes
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 3 Channels
required: sms:false
requires dependency: HTANChannelMetadataID
requires dependency: ChannelID
requires dependency: ChannelName
requires dependency: ChannelPassedQC
requires dependency: CycleNumber
requires dependency: SubCycleNumber
requires dependency: AntibodyRole
requires dependency: TargetName
requires dependency: AntibodyName
requires dependency: RRIDidentifier
requires dependency: Fluorophore
requires dependency: Clone
requires dependency: Lot
requires dependency: Vendor
requires dependency: CatalogNumber
requires dependency: ExcitationWavelength
requires dependency: EmissionWavelength
requires dependency: ExcitationBandwidth
requires dependency: EmissionBandwidth
requires dependency: MetalIsotopeElement
requires dependency: MetalIsotopeMass
requires dependency: OligoBarcodeUpperStrand
requires dependency: OligoBarcodeLowerStrand
requires dependency: Dilution
requires dependency: Concentration

http://schema.biothings.io/10xVisiumSpatialTranscriptomics-RNA-seqLevel1
type: Class
comment: Files contain raw RNA-seq data associated with spot/slide data.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10x Visium Spatial Transcriptomics - RNA-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: RunID
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: ReadIndicator
requires dependency: SpatialRead1
requires dependency: SpatialRead2
requires dependency: SpatialLibraryConstructionMethod
requires dependency: LibraryPreparationDaysfromIndex
requires dependency: SequencingLibraryConstructionDaysfromIndex
requires dependency: EndBias
requires dependency: ReverseTranscriptionPrimer
requires dependency: SequencingPlatform
requires dependency: CaptureArea
requires dependency: ProtocolLink
requires dependency: SlideVersion
requires dependency: SlideID
requires dependency: ImageRe-orientation
requires dependency: PermeabilizationTime
requires dependency: RIN
requires dependency: DV200

CaptureArea
type: Class
comment: Area (or Capture Area) - One of the either four or two active regions where tissue can be placed on a Visium slide. Each area is intended to contain only one tissue sample. Slide areas are named consecutively from top to bottom: A1, B1, C1, D1 for Visium slides with 6.5 mm Capture Area and A, B for CytAssist slides with 11 mm Capture Area. Both CytAssist slides with 6.5 mm Capture Area and Gateway Slides contain only two slide areas, A1 and D1.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: A
range includes: B
range includes: C
range includes: D
range includes: A1
range includes: B1
range includes: C1
range includes: D1
display name: Capture Area
required: sms:false

SlideVersion
type: Class
comment: Version of imaging slide used. Slide version is critical for the analysis of the sequencing data as different slides have different capture area layouts.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: V1
range includes: V2
range includes: V3
range includes: V4
display name: Slide Version
required: sms:false

SlideID
type: Class
comment: For Visium, it is the unique identifier printed on the label of each Visium slide. The serial number starts with V followed by a number which can range between one through five and ends with a dash and a three digit number, such as 123. For CosMx, this refers to the loaded Flow Cell ID. For Xenium, this ID indicates the slide orientation, as it matches the relative location of the ID on the physical Xenium slide.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Slide ID
required: sms:false

ImageRe-orientation
type: Class
comment: To ensure good fiducial alignment and tissue spots detection, it is important to correct for this shift in orientation.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: TRUE
range includes: FALSE
display name: Image Re-orientation
required: sms:false

PermeabilizationTime
type: Class
comment: Fixed and stained tissue sections are permeabilized for different times. Each Capture Area captures polyadenylated mRNA from the attached tissue section. Measure is provided in minutes.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Permeabilization Time
required: sms:false

http://schema.biothings.io/10xVisiumSpatialTranscriptomics-RNA-seqLevel2
type: Class
comment: Alignment workflows downstream of Spatial Transcriptomics RNA-seq Level 1.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10x Visium Spatial Transcriptomics - RNA-seq Level 2
required: sms:false
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: Checksum
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: UMITag
requires dependency: WhitelistSpatialBarcodeFileLink
requires dependency: SpatialBarcodeTag
requires dependency: AppliedHardTrimming
requires dependency: WorkflowVersion
requires dependency: WorkflowLink
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL
requires dependency: GenomeAnnotationURL
requires dependency: HTANParentBiospecimenID
requires dependency: RunID
requires dependency: CaptureArea

WhitelistSpatialBarcodeFileLink
type: Class
comment: Link to file listing all possible spatial barcodes. URL
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Whitelist Spatial Barcode File Link
required: sms:true

http://schema.biothings.io/10xVisiumSpatialTranscriptomics-AuxiliaryFiles
type: Class
comment: Auxiliary data associated with spot/slide analysis (aligned Images, quality control files, etc) from Spatial Transcriptomics.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10x Visium Spatial Transcriptomics - Auxiliary Files
required: sms:false
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: RunID
requires dependency: VisiumFileType
requires dependency: SlideID
requires dependency: CaptureArea
requires dependency: WorkflowVersion
requires dependency: WorkflowLink

VisiumFileType
type: Class
comment: The file type generated for the visium experiment.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: Referencepng
range includes: Referencejpg
range includes: Jsonscalefactors
range includes: Probedatasetcsv
range includes: Qcresulthtml
range includes: Filteredmex
range includes: Unfilteredmex
range includes: TissuePositions
range includes: Barcodes
range includes: Features
range includes: Fiducialimagepng
range includes: Fiducialimagejpg
range includes: Detectedimagepng
range includes: Detectedjpg
range includes: Highresimage
range includes: Lowresimage
display name: Visium File Type
required: sms:true

http://schema.biothings.io/10xVisiumSpatialTranscriptomics-RNA-seqLevel3
type: Class
comment: Processed data files based on Spatial Transcriptomics RNA-seq Level 2 and Spatial Transcriptomics Auxiliary files.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10x Visium Spatial Transcriptomics - RNA-seq Level 3
required: sms:false
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: RunID
requires dependency: VisiumFileType
requires dependency: WorkflowVersion
requires dependency: WorkflowLink
requires dependency: CaptureArea
requires dependency: Spotsundertissue
requires dependency: MeanReadsperSpatialSpot
requires dependency: MedianNumberGenesperSpatialSpot
requires dependency: SequencingSaturation
requires dependency: ProportionReadsMapped
requires dependency: ProportionReadsMappedtoTranscriptome
requires dependency: MedianUMICountsperSpot

Spotsundertissue
type: Class
comment: The number of barcodes associated with a spot under tissue.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Spots under tissue
required: sms:true
validation rules: num

MeanReadsperSpatialSpot
type: Class
comment: The number of reads, both under and outside of tissue, divided by the number of barcodes associated with a spot under tissue.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Mean Reads per Spatial Spot
required: sms:true
validation rules: num

SequencingSaturation
type: Class
comment: The fraction of reads originating from an already-observed UMI. This is a function of library complexity and sequencing depth. More specifically, this is the fraction of confidently mapped, valid spot-barcode, valid UMI reads that had a non-unique (spot-barcode, UMI, gene).
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Sequencing Saturation
required: sms:true

ProportionReadsMappedtoTranscriptome
type: Class
comment: Fraction of reads that mapped to a unique gene in the transcriptome. The read must be consistent with annotated splice junctions. These reads are considered for UMI counting.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Proportion Reads Mapped to Transcriptome
required: sms:true

http://schema.biothings.io/10xVisiumSpatialTranscriptomics-RNA-seqLevel4
type: Class
comment: Processed data files based on Spatial Transcriptomics RNA-seq Level 3.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10x Visium Spatial Transcriptomics - RNA-seq Level 4
required: sms:false
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: RunID
requires dependency: WorkflowVersion
requires dependency: WorkflowLink
requires dependency: VisiumWorkflowType
requires dependency: VisiumWorkflowParametersDescription

VisiumWorkflowType
type: Class
comment: Generic name for the workflow used to analyze the visium data set.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Visium Workflow Type
required: sms:true

VisiumWorkflowParametersDescription
type: Class
comment: Parameters used to run the workflow..
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Visium Workflow Parameters Description
required: sms:true

Referencepng
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: reference png
required: sms:false

Referencejpg
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: reference jpg
required: sms:false

Jsonscalefactors
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: json scale factors
required: sms:false

Probedatasetcsv
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: probe dataset csv
required: sms:false

Qcresulthtml
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: qc result html
required: sms:false

Filteredmex
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: filtered mex
required: sms:false

Unfilteredmex
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: unfiltered mex
required: sms:false

TissuePositions
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: tissue_positions
required: sms:false

Barcodes
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: barcodes
required: sms:false

Features
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: features
required: sms:false

Fiducialimagepng
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: fiducial image png
required: sms:false

Fiducialimagejpg
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: fiducial image jpg
required: sms:false

Detectedimagepng
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: detected image png
required: sms:false

Detectedjpg
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: detected jpg
required: sms:false

Highresimage
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: high res image
required: sms:false

Lowresimage
type: Class
comment: TBD
subclass of: VisiumFileType
is part of: schema.biothings.io
display name: low res image
required: sms:false

A
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: A
required: sms:false

B
type: Class
comment: TBD
subclass of: CaptureArea
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: B
required: sms:false

C
type: Class
comment: TBD
subclass of: CaptureArea
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: C
required: sms:false

D
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: D
required: sms:false

A1
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: A1
required: sms:false

B1
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: B1
required: sms:false

C1
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: C1
required: sms:false

D1
type: Class
comment: TBD
subclass of: CaptureArea
is part of: schema.biothings.io
display name: D1
required: sms:false

V1
type: Class
comment: TBD
subclass of: SlideVersion
is part of: schema.biothings.io
display name: V1
required: sms:false

V2
type: Class
comment: TBD
subclass of: SlideVersion
is part of: schema.biothings.io
display name: V2
required: sms:false

V3
type: Class
comment: TBD
subclass of: SlideVersion
is part of: schema.biothings.io
display name: V3
required: sms:false

V4
type: Class
comment: TBD
subclass of: SlideVersion
is part of: schema.biothings.io
display name: V4
required: sms:false

TRUE
type: Class
comment: TBD
subclass of: ImageRe-orientation
is part of: schema.biothings.io
display name: TRUE
required: sms:false

FALSE
type: Class
comment: TBD
subclass of: ImageRe-orientation
is part of: schema.biothings.io
display name: FALSE
required: sms:false

SpatialBarcodeLength
type: Class
comment: Length of spot barcode read (in bp): number
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Spatial Barcode Length
required: sms:true

Smart-seq2
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: Smart-seq2
required: sms:false

Smart-SeqV4
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: Smart-SeqV4
required: sms:false

10xV1.0
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10xV1.0
required: sms:false

10xV1.1
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10xV1.1
required: sms:false

10xV2
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10xV2
required: sms:false

10xV3
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10xV3
required: sms:false

10xV3.1
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10xV3.1
required: sms:false

Drop-seq
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: Drop-seq
required: sms:false

InDropsV2
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: inDropsV2
required: sms:false

InDropsV3
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: inDropsV3
required: sms:false

TruDrop
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: TruDrop
required: sms:false

NexteraXT
type: Class
comment: TBD
subclass of: SpatialLibraryConstructionMethod
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: Nextera XT
required: sms:false

UMIBarcodeOffset
type: Class
comment: Start position of UMI barcode in the sequence. Values: number, 0 for start of read
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: UMI Barcode Offset
required: sms:true

UMIBarcodeLength
type: Class
comment: Length of UMI barcode read (in bp): number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: UMI Barcode Length
required: sms:true

http://schema.biothings.io/NanoStringGeoMxDSPSpatialTranscriptomicsLevel1
type: Class
comment: Files contain raw data output from the NanoString GeoMx DSP Pipeline. These can include RCC or DCC Files.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: NanoString GeoMx DSP Spatial Transcriptomics Level 1
required: sms:false
requires component: Biospecimen
requires component: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
requires component: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: SynapseIDofGeoMxDSPPKCFile
requires dependency: GeoMxDSPNGSSequencingPlatform
requires dependency: GeoMxDSPNGSLibrarySelectionMethod
requires dependency: GeoMxDSPNGSLibraryPreparationKitName
requires dependency: GeoMxDSPLibraryPreparationKitVendor
requires dependency: GeoMxDSPLibraryPreparationKitVersion
requires dependency: SynapseIDofGeoMxLabWorksheetFile
requires dependency: SoftwareandVersion

SynapseIDofGeoMxDSPPKCFile
type: Class
comment: The Synapse ID(s) associated with the PKC mapping file for the assay. Multiple files are listed as comma separated values.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Synapse ID of GeoMx DSP PKC File
required: sms:true
validation rules: list
validation rules: regex match syn\d+

GeoMxDSPNGSSequencingPlatform
type: Class
comment: A platform is an object aggregate that is the set of instruments and software needed to perform a process [OBI_0000050]. Specific model of the sequencing instrument.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP NGS Sequencing Platform
required: sms:false

GeoMxDSPNGSLibrarySelectionMethod
type: Class
comment: How RNA molecules are isolated.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP NGS Library Selection Method
required: sms:false

GeoMxDSPNGSLibraryPreparationKitName
type: Class
comment: Name of Library Preparation Kit. String
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP NGS Library Preparation Kit Name
required: sms:false

GeoMxDSPLibraryPreparationKitVendor
type: Class
comment: Vendor of Library Preparation Kit. String
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Library Preparation Kit Vendor
required: sms:false

GeoMxDSPLibraryPreparationKitVersion
type: Class
comment: Version of Library Preparation Kit. String
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Library Preparation Kit Version
required: sms:false

SynapseIDofGeoMxLabWorksheetFile
type: Class
comment: Synapse ID(s) of Lab Worksheet Files output from the GeoMx DSP workflow. Multiple files are listed as comma separated values.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Synapse ID of GeoMx Lab Worksheet File
required: sms:false
validation rules: list
validation rules: regex match syn\d+

NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
type: Class
comment: GeoMx ROI and Segment Metadata Attributes. The assayed biospecimen should be reported one per row with the associated ROI coordinates.
subclass of: Assay
is part of: schema.biothings.io
display name: NanoString GeoMx DSP ROI RCC Segment Annotation Metadata
required: sms:false
requires dependency: HTANParentBiospecimenID
requires dependency: Scanname
requires dependency: ROIname
requires dependency: Segmentname
requires dependency: ROIXCoordinate
requires dependency: ROIYCoordinate
requires dependency: Tags
requires dependency: QCstatus
requires dependency: ScanHeight
requires dependency: ScanWidth
requires dependency: ScanOffsetX
requires dependency: ScanOffsetY
requires dependency: BindingDensity
requires dependency: Positivenormfactor
requires dependency: Surfacearea
requires dependency: Nucleicount
requires dependency: TissueStain

NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
type: Class
comment: GeoMx ROI and Segment Metadata Attributes. The assayed biospecimen should be reported one per row with the associated ROI coordinates.
subclass of: Assay
is part of: schema.biothings.io
display name: NanoString GeoMx DSP ROI DCC Segment Annotation Metadata
required: sms:false
requires dependency: HTANParentBiospecimenID
requires dependency: Scanname
requires dependency: Slidename
requires dependency: ROIname
requires dependency: Segmentname
requires dependency: ROIXCoordinate
requires dependency: ROIYCoordinate
requires dependency: Tags
requires dependency: ScanHeight
requires dependency: ScanWidth
requires dependency: ScanOffsetX
requires dependency: ScanOffsetY
requires dependency: Surfacearea
requires dependency: Nucleicount
requires dependency: SequencingSaturation
requires dependency: MapQ30
requires dependency: Rawreads
requires dependency: Stitchedreads
requires dependency: Alignedreads
requires dependency: Deduplicatedreads
requires dependency: InSituNegativemedian
requires dependency: Biologicalprobemedian

GeoMxDSPAssayType
type: Class
comment: The assay type which was used for the GeoMx DSP pipeline.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: RNAnCounter
range includes: ProteinnCounter
range includes: ProteinNGS
range includes: RNANGS
display name: GeoMx DSP Assay Type
required: sms:true

RNAnCounter
type: Class
comment: TBD
subclass of: GeoMxDSPAssayType
is part of: schema.biothings.io
display name: RNA nCounter
required: sms:false

ProteinnCounter
type: Class
comment: TBD
subclass of: GeoMxDSPAssayType
is part of: schema.biothings.io
display name: Protein nCounter
required: sms:false

ProteinNGS
type: Class
comment: TBD
subclass of: GeoMxDSPAssayType
is part of: schema.biothings.io
display name: Protein NGS
required: sms:false

RNANGS
type: Class
comment: TBD
subclass of: GeoMxDSPAssayType
is part of: schema.biothings.io
display name: RNA NGS
required: sms:false

http://schema.biothings.io/NanoStringGeoMxDSPSpatialTranscriptomicsLevel3
type: Class
comment: Files contain processed data from the NanoString GeoMx DSP Pipeline. This level depends on GeoMx Level 1 and Imaging Level 2.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: NanoString GeoMx DSP Spatial Transcriptomics Level 3
required: sms:false
requires component: ImagingLevel2
requires component: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
requires component: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: GeoMxDSPAssayType
requires dependency: SynapseIDofGeoMxDSPROISegmentAnnotationFile
requires dependency: GeoMxDSPUniqueProbeCount
requires dependency: GeoMxDSPUniqueTargetCount
requires dependency: GeoMxDSPGenomicReference
requires dependency: MatrixType
requires dependency: GeoMxDSPWorkflowType
requires dependency: GeoMxDSPWorkflowParameterDescription
requires dependency: GeoMxDSPWorkflowLink

SynapseIDofGeoMxDSPROISegmentAnnotationFile
type: Class
comment: Synapse ID(s) for ROI/Segmentation annotations in the GeoMx DSP experiment.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Synapse ID of GeoMx DSP ROI Segment Annotation File
required: sms:true
validation rules: list
validation rules: regex match syn\d+

GeoMxDSPUniqueProbeCount
type: Class
comment: Total number of unique probes reported.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Unique Probe Count
required: sms:false
validation rules: num

GeoMxDSPUniqueTargetCount
type: Class
comment: Total number of unique genes reported.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Unique Target Count
required: sms:false
validation rules: num

GeoMxDSPGenomicReference
type: Class
comment: Exact version of the human genome reference used in the alignment of reads (e.g. https://www.gencodegenes.org/human/). Only applicable to some applications in GeoMx
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Genomic Reference
required: sms:false
validation rules: num

GeoMxDSPWorkflowType
type: Class
comment: Generic name for the workflow used to analyze the GeoMx DSP data set.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Workflow Type
required: sms:false

GeoMxDSPWorkflowParameterDescription
type: Class
comment: Parameters used to run the GeoMx DSP workflow.
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Workflow Parameter Description
required: sms:false

GeoMxDSPWorkflowLink
type: Class
comment: Link to workflow or command. DockStore.org recommended. URL
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: GeoMx DSP Workflow Link
required: sms:false

Scanname
type: Class
comment: GeoMx Scan name (as appears in Segment Summary)
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Scan name
required: sms:true

ROIname
type: Class
comment: ROI name (application generated). For Xenium this is referred to as the “region name”
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: ROI name
required: sms:true

Segmentname
type: Class
comment: Name given to segment at time of generation
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Segment name
required: sms:true

ROIXCoordinate
type: Class
comment: X location within the image
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: ROI X Coordinate
required: sms:true

ROIYCoordinate
type: Class
comment: Y location within the image
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: ROI Y Coordinate
required: sms:true

Tags
type: Class
comment: Unique descriptor of a variable group (ie. MAPK+)
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Tags
required: sms:true

QCstatus
type: Class
comment: ROI quality control flag as reported by the application
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: QC status
required: sms:false

ScanHeight
type: Class
comment: Height of the scan for GeoMx Analysis
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Scan Height
required: sms:true

ScanWidth
type: Class
comment: Width of the scan for GeoMx Analysis
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Scan Width
required: sms:true

ScanOffsetX
type: Class
comment: Offset X of the scan for GeoMx Analysis
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Scan Offset X
required: sms:true

ScanOffsetY
type: Class
comment: Offset Y of the scan for GeoMx Analysis
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Scan Offset Y
required: sms:true

BindingDensity
type: Class
comment: The binding density as reported by the application
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Binding Density
required: sms:false

Positivenormfactor
type: Class
comment: The Positive Control Normalization factor calculated using pos-hyb controls
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Positive norm factor
required: sms:false

Surfacearea
type: Class
comment: Surface area of the ROI in square microns (µm^2). In CosMx, this is referred to as the Scan Area. In Xenium, this is referred to as the Region Area
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Surface area
required: sms:true

Nucleicount
type: Class
comment: Number of nuclei detected in the segment (if applicable)
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Nuclei count
required: sms:true

TissueStain
type: Class
comment: e.g. CD45 or PanCK (if masking was performed)
subclass of: NanoStringGeoMxDSPROIRCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Tissue Stain
required: sms:false

Slidename
type: Class
comment: Similar to a Run ID, the slide name indicates the slide a given ROI is linked to (as reported in Segment Summary).
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Slide name
required: sms:false

Rawreads
type: Class
comment: Reads not yet analyzed in any way to be used for data analysis. The number of reads that pass filter from the flow cell represented in the FASTQ file.
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Raw reads
required: sms:false

Stitchedreads
type: Class
comment: Represents consensus from the overlapping sequence of read 1 and 2. This is a % of the aligned reads that were overlapped and consensus confirmed, usually upward of 80% but less in terms of number of reads than aligned reads
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Stitched reads
required: sms:false

Alignedreads
type: Class
comment: Is a sequence that has been aligned to a gene/probe. Typically these reads can number from the hundreds of thousands to tens of millions. In GeoMx alignment is via mapping the RTS ID to a white list of sequences that represent targets.
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Aligned reads
required: sms:false

Deduplicatedreads
type: Class
comment: Is the replacement of blocks of duplicate data with a Virtual Index Pointer linking the new sub-block to the existing block of data in a duplicate repository. This is used to reduce the amount of space need to store the data.
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Deduplicated reads
required: sms:false

InSituNegativemedian
type: Class
comment: Is the median of all negative control probes for a given segment. A measure of signal to background for each segment.
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: In Situ Negative median
required: sms:false

Biologicalprobemedian
type: Class
comment: Is the median count from all probes except the negative control probes. A measure of signal to background for each segment
subclass of: NanoStringGeoMxDSPROIDCCSegmentAnnotationMetadata
is part of: schema.biothings.io
display name: Biological probe median
required: sms:false

HI-C-seqLevel1
type: Class
comment: Unaligned sequence data
subclass of: Sequencing
is part of: schema.biothings.io
display name: HI-C-seq Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: Filename
requires dependency: FileFormat
requires dependency: GenomicReference
requires dependency: SequencingPlatform
requires dependency: NucleicAcidSource
requires dependency: TechnicalReplicateGroup
requires dependency: TranspositionReaction
requires dependency: CrosslinkingCondtion
requires dependency: DNADigestionCondition
requires dependency: NucleiPermeabilizationMethod
requires dependency: LigationCondition
requires dependency: BiotinEnrichment
requires dependency: DNAInputAmount
requires dependency: TotalReads
requires dependency: ProtocolLink

CrosslinkingCondtion
type: Class
comment: Detailed condition for DNA crosslinking
subclass of: Sequencing
is part of: schema.biothings.io
display name: Crosslinking Condtion
required: sms:true

DNADigestionCondition
type: Class
comment: Enzymes and treatment length/temperature for genome digestion
subclass of: Sequencing
is part of: schema.biothings.io
display name: DNA Digestion Condition
required: sms:true

NucleiPermeabilizationMethod
type: Class
comment: Detergent and treatment condition for nuclei permeabilization and crosslinking softening
subclass of: Sequencing
is part of: schema.biothings.io
display name: Nuclei Permeabilization Method
required: sms:true

LigationCondition
type: Class
comment: Name of ligase and condition for proximity ligation
subclass of: Sequencing
is part of: schema.biothings.io
display name: Ligation Condition
required: sms:true

BiotinEnrichment
type: Class
comment: Whether biotin is used for enriching ligation product
subclass of: Sequencing
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Biotin Enrichment
required: sms:true

DNAInputAmount
type: Class
comment: Amount of DNA for library construction, in nanograms.
subclass of: Sequencing
is part of: schema.biothings.io
display name: DNA Input Amount
required: sms:true
validation rules: int

HI-C-seqLevel2
type: Class
comment: Aligned read pairs, contact matrix
subclass of: Sequencing
is part of: schema.biothings.io
display name: HI-C-seq Level 2
required: sms:false
requires component: HI-C-seqLevel1
requires dependency: Component
requires dependency: HTANDataFileID
requires dependency: HTANParentDataFileID
requires dependency: Filename
requires dependency: FileFormat
requires dependency: GenomicReference
requires dependency: AlignedReadLength
requires dependency: Tool
requires dependency: Resolution
requires dependency: NormalizationMethod

AlignedReadLength
type: Class
comment: Read length used for alignment if hard trimming was applied
subclass of: Sequencing
is part of: schema.biothings.io
display name: Aligned Read Length
required: sms:true

Tool
type: Class
comment: Were any software or computational tools generated for this content
subclass of: Publication
is part of: schema.biothings.io
range includes: Yes
range includes: No
display name: Tool
required: sms:true

Resolution
type: Class
comment: Binning size used for generating contact matrix, in basepair.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Resolution
required: sms:true

HI-C-seqLevel3
type: Class
comment: Summary data for the HI-C-seq assay.
subclass of: Sequencing
is part of: schema.biothings.io
display name: HI-C-seq Level 3
required: sms:false
requires component: HI-C-seqLevel2
requires dependency: Component
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: Filename
requires dependency: FileFormat
requires dependency: GenomicReference
requires dependency: StripeCalling
requires dependency: LoopWindow
requires dependency: StripeWindow
requires dependency: LoopCalling

StripeCalling
type: Class
comment: Tool used for identifying architectural stripe-forming, interaction hotspots.
subclass of: Sequencing
is part of: schema.biothings.io
range includes: MACS2
range includes: Other
display name: Stripe Calling
required: sms:true

LoopWindow
type: Class
comment: Binning size used for calling significant dot interactions (loops)
subclass of: Sequencing
is part of: schema.biothings.io
display name: Loop Window
required: sms:true
validation rules: list like
validation rules: regex search -?\d+

StripeWindow
type: Class
comment: Binning size used for calling significant architectural stripes. Can be an integer or comma-separated list of integers indicating bin size and sliding window size if different.
subclass of: Sequencing
is part of: schema.biothings.io
display name: Stripe Window
required: sms:true
validation rules: list like
validation rules: regex search -?\d+

LoopCalling
type: Class
comment: Tool used for identifying loop interactions
subclass of: Sequencing
is part of: schema.biothings.io
range includes: HiCCUPS
range includes: Cooltools
range includes: Other
display name: Loop Calling
required: sms:true

Yes
type: Class
comment: TBD
subclass of: BiotinEnrichment
subclass of: ChannelPassedQC
subclass of: Pyramid
subclass of: Zstack
subclass of: Tseries
subclass of: PassedQC
subclass of: WellIndex
subclass of: CryopreservedCellsinSample
subclass of: PrematureAtBirth
subclass of: AlcoholHistory
subclass of: AsbestosExposure
subclass of: CoalDustExposure
subclass of: EnvironmentalTobaccoSmokeExposure
subclass of: RadonExposure
subclass of: RespirableCrystallineSilicaExposure
subclass of: SecondhandSmokeasChild
subclass of: HepatitisSustainedVirologicalResponse
subclass of: HAARTTreatmentIndicator
subclass of: RiskFactorTreatment
subclass of: ChemoConcurrenttoRadiation
subclass of: TreatmentEffectIndicator
subclass of: SatelliteMetastasisPresentIndicator
subclass of: Immunosuppression
subclass of: COVID19OccurrenceIndicator
subclass of: COVID19PositiveLabTestIndicator
subclass of: COVID19CancerTreatmentFollowup
subclass of: KnownGeneticPredispositionMutation
subclass of: MismatchRepairMutation
subclass of: NonNodalTumorDeposits
subclass of: PregnantatDiagnosis
subclass of: PriorMalignancy
subclass of: PriorTreatment
subclass of: LymphaticInvasionPresent
subclass of: PerineuralInvasionPresent
subclass of: SynchronousMalignancy
subclass of: TumorConfinedtoOrganofOrigin
subclass of: HistoryofPriorColonPolyps
subclass of: FamilyColonCancerHistoryIndicator
subclass of: FamilyMedicalHistoryColorectalPolypDiagnosis
subclass of: PatientColonoscopyPerformedIndicator
subclass of: ColorectalCancerKRASIndicator
subclass of: ColonPolypOccurenceIndicator
subclass of: FamilyHistoryColorectalPolyp
subclass of: ColorectalPolypNewIndicator
subclass of: HormoneTherapyBreastCancerPreventionIndicator
subclass of: MultifocalBreastCarcinomaPresentIndicator
subclass of: MulticentricBreastCarcinomaPresentIndicator
subclass of: HistoryofBlisteringSunburn
subclass of: Tool
subclass of: PublicationcontainsHTANID
subclass of: BarrettsEsophagusGobletCellsPresent
subclass of: TreatmentorTherapy
is part of: schema.biothings.io
display name: yes
required: sms:false

No
type: Class
comment: TBD
subclass of: BiotinEnrichment
subclass of: Pyramid
subclass of: Zstack
subclass of: Tseries
subclass of: WellIndex
subclass of: CryopreservedCellsinSample
subclass of: ToTrimAdapterSequence
subclass of: AppliedHardTrimming
subclass of: PseudoAlignmentUsed
subclass of: FusionGeneDetected
subclass of: PrematureAtBirth
subclass of: AlcoholHistory
subclass of: AsbestosExposure
subclass of: CoalDustExposure
subclass of: EnvironmentalTobaccoSmokeExposure
subclass of: RadonExposure
subclass of: RespirableCrystallineSilicaExposure
subclass of: SecondhandSmokeasChild
subclass of: HepatitisSustainedVirologicalResponse
subclass of: HAARTTreatmentIndicator
subclass of: ProgressionorRecurrence
subclass of: RiskFactorTreatment
subclass of: ChemoConcurrenttoRadiation
subclass of: TreatmentEffectIndicator
subclass of: SatelliteMetastasisPresentIndicator
subclass of: Immunosuppression
subclass of: COVID19OccurrenceIndicator
subclass of: COVID19PositiveLabTestIndicator
subclass of: COVID19CancerTreatmentFollowup
subclass of: KnownGeneticPredispositionMutation
subclass of: MismatchRepairMutation
subclass of: NonNodalTumorDeposits
subclass of: PregnantatDiagnosis
subclass of: PriorMalignancy
subclass of: PriorTreatment
subclass of: AnaplasiaPresent
subclass of: LymphaticInvasionPresent
subclass of: PerineuralInvasionPresent
subclass of: SynchronousMalignancy
subclass of: TumorConfinedtoOrganofOrigin
subclass of: VascularInvasionPresent
subclass of: HistoryofPriorColonPolyps
subclass of: FamilyColonCancerHistoryIndicator
subclass of: FamilyMedicalHistoryColorectalPolypDiagnosis
subclass of: PatientColonoscopyPerformedIndicator
subclass of: ColorectalCancerKRASIndicator
subclass of: ColonPolypOccurenceIndicator
subclass of: FamilyHistoryColorectalPolyp
subclass of: ColorectalPolypNewIndicator
subclass of: HormoneTherapyBreastCancerPreventionIndicator
subclass of: MultifocalBreastCarcinomaPresentIndicator
subclass of: MulticentricBreastCarcinomaPresentIndicator
subclass of: HistoryofBlisteringSunburn
subclass of: Tool
subclass of: Islowestlevel
subclass of: PublicationcontainsHTANID
subclass of: BarrettsEsophagusGobletCellsPresent
subclass of: PrecancerCase
subclass of: TreatmentorTherapy
subclass of: PatientInflammatoryBowelDiseasePersonalMedicaHistory
subclass of: HistoryofAtypicalNevi
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: no
required: sms:false

MACS2
type: Class
comment: TBD
subclass of: StripeCalling
is part of: schema.biothings.io
display name: MACS2
required: sms:false

HiCCUPS
type: Class
comment: TBD
subclass of: LoopCalling
is part of: schema.biothings.io
display name: HiCCUPS
required: sms:false

Cooltools
type: Class
comment: TBD
subclass of: LoopCalling
is part of: schema.biothings.io
display name: Cooltools
required: sms:false

ImagingLevel4
type: Class
comment: Derived imaging data: Object-by-feature array
subclass of: Assay
is part of: schema.biothings.io
display name: Imaging Level 4
required: sms:false
requires component: ImagingLevel3Channels
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANParentChannelMetadataID
requires dependency: HTANDataFileID
requires dependency: Parameterfile
requires dependency: SoftwareandVersion
requires dependency: CommitSHA
requires dependency: NumberofObjects
requires dependency: NumberofFeatures
requires dependency: ImagingObjectClass
requires dependency: ImagingSummaryStatistic

NumberofFeatures
type: Class
comment: The number of features (eg channels) described
subclass of: Imaging
is part of: schema.biothings.io
display name: Number of Features
required: sms:true
validation rules: int

ImagingSummaryStatistic
type: Class
comment: Function used to summarize object/feature intensity
subclass of: Imaging
is part of: schema.biothings.io
range includes: Mean
range includes: Median
range includes: NotSpecified
display name: Imaging Summary Statistic
required: sms:false

SRRSImagingLevel2
type: Class
comment: SRRS-specific HTAN raw and pre-processed image data
subclass of: Assay
is part of: schema.biothings.io
display name: SRRS Imaging Level 2
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: ChannelMetadataFilename
requires dependency: ImagingAssayType
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: Microscope
requires dependency: Objective
requires dependency: NominalMagnification
requires dependency: Pyramid
requires dependency: Zstack
requires dependency: Tseries
requires dependency: PassedQC
requires dependency: FrameAveraging
requires dependency: ImageID
requires dependency: DimensionOrder
requires dependency: PhysicalSizeX
requires dependency: PhysicalSizeXUnit
requires dependency: PhysicalSizeY
requires dependency: PhysicalSizeYUnit
requires dependency: PixelsBigEndian
requires dependency: PlaneCount
requires dependency: SizeC
requires dependency: SizeT
requires dependency: SizeX
requires dependency: SizeY
requires dependency: SizeZ
requires dependency: PixelType

10XGenomicsXeniumISSExperiment
type: Class
comment: All data pertaining to the 10X Genomics Xenium In-Situ Hybridization experiment
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: 10X Genomics Xenium ISS Experiment
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: XeniumBundleContents
requires dependency: SlideID
requires dependency: ROIname
requires dependency: PanelName
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: TotalNumberofCells
requires dependency: TotalNumberofTargets
requires dependency: Surfacearea
requires dependency: ExperimentIFChannels
requires dependency: TranscriptsperCell
requires dependency: PercentofTranscriptswithinCells
requires dependency: DecodedTranscripts
requires dependency: XeniumIFimageHTANFileID
requires dependency: XeniumHEimageHTANFileID

XeniumBundleContents
type: Class
comment: A comma separated list of filenames within the Xenium bundle zip file
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Xenium Bundle Contents
required: sms:true

PanelName
type: Class
comment: The human-readable panel name. This could be the Gene Panel name or Protein Panel name. In Xenium, this refers to the string entered as the name in panel specification (e.g. Xenium Human Immuno-Oncology Add-on B Gene Expression). In CosMx, this refers to the panel name as it appears in the CosMx catalog (e.g. CosMx Human Universal Cell Characterization Panel (1000-plex))
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Panel Name
required: sms:true

TotalNumberofCells
type: Class
comment: The total number of cells analyzed on the flow cell
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Total Number of Cells
required: sms:true

TotalNumberofTargets
type: Class
comment: Refers to the target of an assay. Can be genes/transcripts or probes
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Total Number of Targets
required: sms:true

ExperimentIFChannels
type: Class
comment: A comma-separated list with any number of channels the user deems appropriate(Example: PanCK, CD45, CD3, DAPI)
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Experiment IF Channels
required: sms:true

TranscriptsperCell
type: Class
comment: Mean or Median transcript count per cell analyzed on the flow cell or slide
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Transcripts per Cell
required: sms:true

PercentofTranscriptswithinCells
type: Class
comment: The percentage of transcripts assigned to assayed cells
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Percent of Transcripts within Cells
required: sms:true

DecodedTranscripts
type: Class
comment: In Xenium, this is the number of high-quality, decoded-to-gene nuclear transcripts divided by the total segmented nuclear area to get a transcript density (units are reported in 100um^2).
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Decoded Transcripts
required: sms:true

XeniumIFimageHTANFileID
type: Class
comment: The HTAN Data File ID of a Imaging Level 2 file
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Xenium IF image HTAN File ID
required: sms:false

XeniumHEimageHTANFileID
type: Class
comment: The HTAN Data File ID of a Imaging Level 2 file
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Xenium HE image HTAN File ID
required: sms:false

RPPALevel2
type: Class
comment: Array based protemics. Each dilution curve of spot intensities is fitted using the monotone increasing B-spline model in the SuperCurve R package. This fits a single curve using all the samples on a slide with the signal intensity as the response variable and the dilution steps as independent variables. The fitted curve is plotted with the signal intensities on the y-axis and the log2-concentration of proteins on the x-axis for diagnostic purposes.
subclass of: Assay
is part of: schema.biothings.io
display name: RPPA Level 2
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: HTANRPPAAntibodyTable
requires dependency: AssayType
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion

HTANRPPAAntibodyTable
type: Class
comment: A table containing antibody level metadata for RPPA
subclass of: RPPALevel2
is part of: schema.biothings.io
display name: HTAN RPPA Antibody Table
required: sms:true
requires dependency: HTANRPPAAntibodyTableID
requires dependency: Filename
requires dependency: FileFormat
requires dependency: AbNameReportedonDataset
requires dependency: GENCODEGeneSymbolTarget
requires dependency: UNIPROTProteinIDTarget
requires dependency: PhosphoproteinFlag
requires dependency: Vendor
requires dependency: CatalogNumber
requires dependency: InternalAbID
requires dependency: Species
requires dependency: RPPADilution
requires dependency: PhosphoSite
requires dependency: RPPAValidationStatus
requires dependency: Clone
requires dependency: Clonality
requires dependency: AntibodyNotes

HTANRPPAAntibodyTableID
type: Class
comment: HTAN identifier associated with RPPA antibody level metadata. Identical for every row of the table.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: HTAN RPPA Antibody Table ID
required: sms:true

AbNameReportedonDataset
type: Class
comment: The antibody name.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: Ab Name Reported on Dataset
required: sms:true

GENCODEGeneSymbolTarget
type: Class
comment: The comma separated list of gene symbols targeted by the antibody.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: GENCODE Gene Symbol Target
required: sms:true

UNIPROTProteinIDTarget
type: Class
comment: The comma separated list of UNIPROT IDs targeted by the antibody.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: UNIPROT Protein ID Target
required: sms:true

PhosphoproteinFlag
type: Class
comment: A flag the denotes if an antibody targets a phosphoprotein.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
range includes: True
range includes: False
display name: Phosphoprotein Flag
required: sms:true

Vendor
type: Class
comment: Vendor
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Vendor
required: sms:false

CatalogNumber
type: Class
comment: Catalog Number
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Catalog Number
required: sms:false

InternalAbID
type: Class
comment: Internal lab ID for an antibody.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: Internal Ab ID
required: sms:true

Species
type: Class
comment: Host animal.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
range includes: Mouse
range includes: Rabbit
range includes: Goat
display name: Species
required: sms:true

RPPADilution
type: Class
comment: The dilution ratio.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: RPPA Dilution
required: sms:false

PhosphoSite
type: Class
comment: The protein site for a phosphoprotein targeting antibody. Report AA and site (i.e. S442)
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: Phospho Site
required: sms:false
requires dependency: PhosphoproteinFlag

RPPAValidationStatus
type: Class
comment: Valid = RPPA and WB correlation > 0.7; Use with Caution = RPPA and WB correlation < 0.7; Under Evaluation = Antibody has given mixed results and/or evaluated by another lab; We are in the process of (re)validating; Used for QC = These antibodies are used for tissue sample quality control (QC)
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
range includes: Valid
range includes: UsewithCaution
range includes: UnderEvaluation
range includes: UsedforQC
display name: RPPA Validation Status
required: sms:false

Clone
type: Class
comment: Clone
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Clone
required: sms:false

AntibodyNotes
type: Class
comment: Notes on antibodies replacements and antibody recognition observations.
subclass of: HTANRPPAAntibodyTable
is part of: schema.biothings.io
display name: Antibody Notes
required: sms:false

RPPALevel3
type: Class
comment: Level 3 Reverse Phase Protein Array (RPPA) data contains intra-batch normalized intensities.
subclass of: Assay
is part of: schema.biothings.io
display name: RPPA Level 3
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AssayType
requires dependency: SoftwareandVersion
requires dependency: NormalizationMethod

RPPALevel4
type: Class
comment: Level 4 Reverse Phase Protein Array (RPPA) data contains intra-batch corrected intensities.
subclass of: Assay
is part of: schema.biothings.io
display name: RPPA Level 4
required: sms:false
requires component: RPPALevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParticipantID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID
requires dependency: AssayType
requires dependency: BatchCorrectionMethod

BatchCorrectionMethod
type: Class
comment: Method that was used to batch correct Level 3 data
subclass of: RPPALevel3
is part of: schema.biothings.io
display name: Batch Correction Method
required: sms:false

NanostringCosMxSMIExperiment
type: Class
comment: RNA and Protein Panel assays applied as part of Nanostring CosMx Spatial Molecular Imager (SMI)
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Nanostring CosMx SMI Experiment
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: CosMxBundleContents
requires dependency: SlideID
requires dependency: CosMxAssayType
requires dependency: PanelName
requires dependency: ProtocolLink
requires dependency: SoftwareandVersion
requires dependency: TotalNumberofCells
requires dependency: TotalNumberofTargets
requires dependency: NumberofFOVs
requires dependency: Surfacearea
requires dependency: ExperimentIFChannels
requires dependency: TranscriptsperCell
requires dependency: PercentofTranscriptswithinCells
requires dependency: MeanTotalTranscriptsperArea
requires dependency: UniqueGenes
requires dependency: TotalNegativeProbeCounts

CosMxBundleContents
type: Class
comment: A comma separated list of filenames within the CosMx bundle zip file
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: CosMx Bundle Contents
required: sms:true

CosMxAssayType
type: Class
comment: The specification for barcodes on each image. Either RNA probe or protein antibody according to the assay
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
range includes: RNA
range includes: Protein
display name: CosMx Assay Type
required: sms:true

NumberofFOVs
type: Class
comment: The total number of FOVs recorded for the sample on a single flow cell
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Number of FOVs
required: sms:true

MeanTotalTranscriptsperArea
type: Class
comment: The mean total transcripts per um3
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Mean Total Transcripts per Area
required: sms:true

UniqueGenes
type: Class
comment: The total unique genes detected above background
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Unique Genes
required: sms:false

TotalNegativeProbeCounts
type: Class
comment: Mean Total Negative probe counts/cell
subclass of: SpatialTranscriptomics
is part of: schema.biothings.io
display name: Total Negative Probe Counts
required: sms:true

RNA
type: Class
comment: TBD
subclass of: CosMxAssayType
subclass of: MicroarrayMolecule
is part of: schema.biothings.io
display name: RNA
required: sms:false

Protein
type: Class
comment: TBD
subclass of: CosMxAssayType
subclass of: AnalyteType
is part of: schema.biothings.io
display name: protein
required: sms:false

MassSpectrometryLevel1
type: Class
comment: Mass Spectrometry derived data that includes proteomics, metabolomics, and lipidomics, level 1
subclass of: Assay
is part of: schema.biothings.io
display name: Mass Spectrometry Level 1
required: sms:false
requires component: Biospecimen
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentBiospecimenID
requires dependency: HTANDataFileID
requires dependency: MSBatchID
requires dependency: MS-basedAssayType
requires dependency: AnalyteType
requires dependency: MS-basedTargeted
requires dependency: MSInstrumentVendorandModel
requires dependency: MSSource
requires dependency: Polarity
requires dependency: MassRangeLowValue
requires dependency: MassRangeHighValue
requires dependency: DataCollectionMode
requires dependency: MSScanMode
requires dependency: MSLabeling
requires dependency: ProtocolLink
requires dependency: LCInstrumentVendorandModel
requires dependency: LCColumnVendorandModel
requires dependency: LCResin
requires dependency: LCLengthValue
requires dependency: LCTempValue
requires dependency: LCIDValue
requires dependency: LCFlowRate
requires dependency: LCGradient
requires dependency: LCMobilePhaseA
requires dependency: LCMobilePhaseB
requires dependency: SoftwareandVersion
requires dependency: MSInstrumentMetadataFile

MSBatchID
type: Class
comment: Batch ID indicating a set of samples that were run together.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: MS Batch ID
required: sms:true

MS-basedAssayType
type: Class
comment: Analytes are the target molecules being measured with the assay.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: LC-MS
range includes: MS
range includes: TMT
display name: MS-based Assay Type
required: sms:true

AnalyteType
type: Class
comment: The kind of molecular specimen analyte: a molecular derivative (I.e. RNA / DNA / Protein Lysate) obtained from a specimen
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: CfDNAAnalyte
range includes: DNAAnalyte
range includes: RNAAnalyte
range includes: TotalRNAAnalyte
range includes: TissueBlockAnalyte
range includes: TissueSectionAnalyte
range includes: PBMCsorPlasmaorSerumAnalyte
range includes: CDNALibrariesAnalyte
range includes: PBMCs
range includes: Plasma
range includes: SerumAnalyte
range includes: Lipid
range includes: Protein
range includes: Metabolite
display name: Analyte Type
required: sms:true

MS-basedTargeted
type: Class
comment: Specifies whether or not a specific molecule(s) is/are targeted for detection/measurement by the assay. Example: The MALDI Imaging analyte is lipids.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: Targeted
range includes: Untargeted
display name: MS-based Targeted
required: sms:true

MSInstrumentVendorandModel
type: Class
comment: An acquisition instrument is the device that contains the signal detection hardware and signal processing software. Assays generate signals such as light of various intensities or color or signals representing the molecular mass.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: MS Instrument Vendor and Model
required: sms:true

MSSource
type: Class
comment: The ion source type used for surface sampling (MALDI, MALDI-2, DESI, or SIMS) or LC-MS/MS data acquisition (nESI)
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: MALDI
range includes: MALDI-2
range includes: DESI
range includes: SIMS
range includes: NESI
range includes: Other
display name: MS Source
required: sms:true

Polarity
type: Class
comment: The polarity of the mass analysis (positive or negative ion modes)
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: Positive
range includes: Negative
display name: Polarity
required: sms:true

MassRangeLowValue
type: Class
comment: The low value of the scanned mass range for MS1 in m/z.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: Mass Range Low Value
required: sms:true

MassRangeHighValue
type: Class
comment: The high value of the scanned mass range for MS1 in m/z.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: Mass Range High Value
required: sms:true

DataCollectionMode
type: Class
comment: Mode of data collection in tandem MS assays. Either DDA (Data-dependent acquisition) or DIA (Data-indemendent acquisition.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: DDA
range includes: DIA
range includes: Other
display name: Data Collection Mode
required: sms:true

MSScanMode
type: Class
comment: Indicates whether experiment is MS, MS/MS, or other (possibly MS3 for TMT)
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
range includes: MS
range includes: MS3
range includes: Other
display name: MS Scan Mode
required: sms:true

MSLabeling
type: Class
comment: Indicates whether samples were labeled prior to MS analysis (e.g., TMT)
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: MS Labeling
required: sms:true

LCInstrumentVendorandModel
type: Class
comment: The manufacturer of the instrument used for LC.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Instrument Vendor and Model
required: sms:true

LCColumnVendorandModel
type: Class
comment: The manufacturer of the LC Column unless self-packed, pulled tip capilary is used and the model number/name of the LC Column - IF custom self-packed, pulled tip calillary is used enter 'Pulled tip capilary'
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Column Vendor and Model
required: sms:true

LCResin
type: Class
comment: Details of the resin used for lc, including vendor, particle size, pore size
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Resin
required: sms:true

LCLengthValue
type: Class
comment: LC column length in cm.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Length Value
required: sms:true

LCTempValue
type: Class
comment: LC temperature in C.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Temp Value
required: sms:true

LCIDValue
type: Class
comment: LC column inner diameter in microns.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC ID Value
required: sms:true

LCFlowRate
type: Class
comment: LC flow rate in nL/min.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Flow Rate
required: sms:true

LCGradient
type: Class
comment: The program dictates the mobile phase solvent composition over the course of the chromatographic run.
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Gradient
required: sms:true

LCMobilePhaseA
type: Class
comment: Composition of mobile phase A
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Mobile Phase A
required: sms:true

LCMobilePhaseB
type: Class
comment: Composition of mobile phase B
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: LC Mobile Phase B
required: sms:true

MSInstrumentMetadataFile
type: Class
comment: Additional file containing instrument metadata details. Use either synapse_path or entity_Id
subclass of: MassSpectrometryLevel1
is part of: schema.biothings.io
display name: MS Instrument Metadata File
required: sms:false

MassSpectrometryLevel2
type: Class
comment: Mass Spectrometry derived data that includes proteomics, metabolomics, and lipidomics, level 2
subclass of: Assay
is part of: schema.biothings.io
display name: Mass Spectrometry Level 2
required: sms:false
requires component: MassSpectrometryLevel1
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: MSAssayCategory
requires dependency: SoftwareandVersion
requires dependency: MassSpectrometryAuxiliaryFile

MSAssayCategory
type: Class
comment: Type of Mass Spectrometry performed.
subclass of: MassSpectrometryLevel2
is part of: schema.biothings.io
display name: MS Assay Category
required: sms:true

MassSpectrometryAuxiliaryFile
type: Class
comment: Auxiliary software parameter file used in mass spectrometry data processing, recorded as synapse ID (syn12345).
subclass of: Assay
is part of: schema.biothings.io
display name: Mass Spectrometry Auxiliary File
required: sms:false
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANParentDataFileID
requires dependency: HTANDataFileID

MassSpectrometryLevel3
type: Class
comment: Mass Spectrometry derived data that includes proteomics, metabolomics, and lipidomics, level 3
subclass of: Assay
is part of: schema.biothings.io
display name: Mass Spectrometry Level 3
required: sms:false
requires component: MassSpectrometryLevel2
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: MSAssayCategory
requires dependency: SoftwareandVersion
requires dependency: MassSpectrometryAuxiliaryFile

MassSpectrometryLevel4
type: Class
comment: Mass Spectrometry derived data that includes proteomics, metabolomics, and lipidomics, level 4
subclass of: Assay
is part of: schema.biothings.io
display name: Mass Spectrometry Level 4
required: sms:false
requires component: MassSpectrometryLevel3
requires dependency: Component
requires dependency: Filename
requires dependency: FileFormat
requires dependency: HTANDataFileID
requires dependency: HTANParentBiospecimenID
requires dependency: HTANParentDataFileID
requires dependency: MSAssayCategory
requires dependency: SoftwareandVersion
requires dependency: MassSpectrometryAuxiliaryFile

HTANChannelMetadataID
type: Class
comment: HTAN ID for this channel metadata table (same for all rows)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: HTAN Channel Metadata ID
required: sms:true

ChannelID
type: Class
comment: This must match the corresponding field in the OME-XML / TIFF header. (eg 'Channel:0:1')
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Channel ID
required: sms:true

ChannelName
type: Class
comment: This must match the corresponding field in the OME-XML / TIFF header. (eg 'Blue' or 'CD45' or 'E-cadherin')
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Channel Name
required: sms:true

ChannelPassedQC
type: Class
comment: Identify stains that did not pass QC but are included in the dataset.
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
range includes: Yes
range includes: No-ChannelFailedQC
display name: Channel Passed QC
required: sms:true

CycleNumber
type: Class
comment: The cycle # in which the co-listed reagent(s) was(were) used. Integer >= 1 (up to number of cycles)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Cycle Number
required: sms:false
validation rules: int

SubCycleNumber
type: Class
comment: Sub cycle number
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Sub Cycle Number
required: sms:false
validation rules: int

AntibodyRole
type: Class
comment: "Is this antibody acting as a primary or secondary antibody"
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
range includes: Primary
range includes: Secondary
range includes: Neither-Dye/Stain
display name: Antibody Role
required: sms:true

TargetName
type: Class
comment: Short descriptive name (abbreviation) for this target (antigen)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Target Name
required: sms:true

AntibodyName
type: Class
comment: Antibody Name (free text (eg “Keratin”, “CD163”, “DNA”))
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Antibody Name
required: sms:true

RRIDidentifier
type: Class
comment: Research Resource Identifier (eg “RRID: AB_394606”)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: RRID identifier
required: sms:true
validation rules: regex match AB_\d+|Not\sApplicable$

Fluorophore
type: Class
comment: Fluorescent dye label (eg Alexa Fluor 488)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Fluorophore
required: sms:false

Lot
type: Class
comment: Lot number from vendor
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Lot
required: sms:false

ExcitationWavelength
type: Class
comment: Center/peak of the excitation spectrum (nm)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Excitation Wavelength
required: sms:false
validation rules: num

EmissionWavelength
type: Class
comment: Center/peak of the emission spectrum (nm)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Emission Wavelength
required: sms:false
validation rules: num

ExcitationBandwidth
type: Class
comment: Nominal width of excitation spectrum (nm)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Excitation Bandwidth
required: sms:false
validation rules: num

EmissionBandwidth
type: Class
comment: Nominal width of emission spectrum (nm)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Emission Bandwidth
required: sms:false
validation rules: num

MetalIsotopeElement
type: Class
comment: Element abbreviation. eg “La” or “Nd”
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
range includes: H
range includes: He
range includes: Li
range includes: Be
range includes: B
range includes: C
range includes: N
range includes: O
range includes: F
range includes: Ne
range includes: Na
range includes: Mg
range includes: Al
range includes: Si
range includes: P
range includes: S
range includes: Cl
range includes: Ar
range includes: K
range includes: Ca
range includes: Sc
range includes: Ti
range includes: V
range includes: Cr
range includes: Mn
range includes: Fe
range includes: Co
range includes: Ni
range includes: Cu
range includes: Zn
range includes: Ga
range includes: Ge
range includes: As
range includes: Se
range includes: Br
range includes: Kr
range includes: Rb
range includes: Sr
range includes: Y
range includes: Zr
range includes: Nb
range includes: Mo
range includes: Tc
range includes: Ru
range includes: Rh
range includes: Pd
range includes: Ag
range includes: Cd
range includes: In
range includes: Sn
range includes: Sb
range includes: Te
range includes: I
range includes: Xe
range includes: Cs
range includes: Ba
range includes: La
range includes: Ce
range includes: Pr
range includes: Nd
range includes: Pm
range includes: Sm
range includes: Eu
range includes: Gd
range includes: Tb
range includes: Dy
range includes: Ho
range includes: Er
range includes: Tm
range includes: Yb
range includes: Lu
range includes: Hf
range includes: Ta
range includes: W
range includes: Re

MetalIsotopeMass
type: Class
comment: Element mass number
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Metal Isotope Mass
required: sms:false
validation rules: int

OligoBarcodeUpperStrand
type: Class
comment: Oligo Barcode - Upper Strand
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Oligo Barcode Upper Strand
required: sms:false

OligoBarcodeLowerStrand
type: Class
comment: Oligo Barcode - Lower Strand
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Oligo Barcode Lower Strand
required: sms:false

Dilution
type: Class
comment: Dilution (eg 1:1000)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Dilution
required: sms:false

Concentration
type: Class
comment: Concentration (eg 10ug/mL)
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Concentration
required: sms:false

No-ChannelFailedQC
type: Class
comment: Channel failed QC
subclass of: ImagingLevel3Channels
subclass of: ChannelPassedQC
is part of: schema.biothings.io
display name: No - Channel Failed QC
required: sms:false
requires dependency: ChannelQCFailureType

ChannelQCFailureType
type: Class
comment: Reason the channel failed QC
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
range includes: Off-targetstaining
range includes: Auto-fluoresence
range includes: Stainingartefacet
range includes: Imagingartefact
range includes: Other/multiplechannelQCfaliuretypes
display name: Channel QC Failure Type
required: sms:false

Off-targetstaining
type: Class
comment: TBD
subclass of: ChannelQCFailureType
is part of: schema.biothings.io
display name: Off-target staining
required: sms:false

Auto-fluoresence
type: Class
comment: TBD
subclass of: ChannelQCFailureType
is part of: schema.biothings.io
display name: Auto-fluoresence
required: sms:false

Stainingartefacet
type: Class
comment: TBD
subclass of: ChannelQCFailureType
is part of: schema.biothings.io
display name: Staining artefacet
required: sms:false

Imagingartefact
type: Class
comment: TBD
subclass of: ChannelQCFailureType
is part of: schema.biothings.io
display name: Imaging artefact
required: sms:false

Other/multiplechannelQCfaliuretypes
type: Class
comment: QC failure type not speficied
subclass of: ImagingLevel3Channels
subclass of: ChannelQCFailureType
is part of: schema.biothings.io
display name: Other/multiple channel QC faliure types
required: sms:false
requires dependency: ChannelQCFailureComment

ChannelQCFailureComment
type: Class
comment: Custom comment on channel QC faliure
subclass of: ImagingLevel3Channels
is part of: schema.biothings.io
display name: Channel QC Failure Comment
required: sms:false

Primary
type: Class
comment: TBD
subclass of: AntibodyRole
subclass of: ClassificationofTumor
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Primary
required: sms:false

Secondary
type: Class
comment: TBD
subclass of: AntibodyRole
is part of: schema.biothings.io
display name: Secondary
required: sms:false

Neither-Dye/Stain
type: Class
comment: TBD
subclass of: AntibodyRole
is part of: schema.biothings.io
display name: Neither-Dye/Stain
required: sms:false

H
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: H
required: sms:false

He
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: He
required: sms:false

Li
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Li
required: sms:false

Be
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Be
required: sms:false

N
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: N
required: sms:false

O
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: O
required: sms:false

F
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: F
required: sms:false

Ne
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ne
required: sms:false

Na
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Na
required: sms:false

Mg
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Mg
required: sms:false

Al
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Al
required: sms:false

Si
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Si
required: sms:false

P
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: P
required: sms:false

S
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: S
required: sms:false

Cl
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cl
required: sms:false

Ar
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ar
required: sms:false

K
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: K
required: sms:false

Ca
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ca
required: sms:false

Sc
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sc
required: sms:false

Ti
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ti
required: sms:false

V
type: Class
comment: TBD
subclass of: MelanomaSpecimenClarkLevelValue
subclass of: FitzpatrickSkinTone
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: V
required: sms:false

Cr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cr
required: sms:false

Mn
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Mn
required: sms:false

Fe
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Fe
required: sms:false

Co
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Co
required: sms:false

Ni
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ni
required: sms:false

Cu
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cu
required: sms:false

Zn
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Zn
required: sms:false

Ga
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ga
required: sms:false

Ge
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ge
required: sms:false

As
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: As
required: sms:false

Se
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Se
required: sms:false

Br
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Br
required: sms:false

Kr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Kr
required: sms:false

Rb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Rb
required: sms:false

Sr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sr
required: sms:false

Y
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Y
required: sms:false

Zr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Zr
required: sms:false

Nb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Nb
required: sms:false

Mo
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Mo
required: sms:false

Tc
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Tc
required: sms:false

Ru
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ru
required: sms:false

Rh
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Rh
required: sms:false

Pd
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pd
required: sms:false

Ag
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ag
required: sms:false

Cd
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cd
required: sms:false

In
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: In
required: sms:false

Sn
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sn
required: sms:false

Sb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sb
required: sms:false

Te
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Te
required: sms:false

I
type: Class
comment: TBD
subclass of: ISSStage
subclass of: MelanomaSpecimenClarkLevelValue
subclass of: FitzpatrickSkinTone
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: I
required: sms:false

Xe
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Xe
required: sms:false

Cs
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cs
required: sms:false

Ba
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ba
required: sms:false

La
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: La
required: sms:false

Ce
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ce
required: sms:false

Pr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pr
required: sms:false

Nd
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Nd
required: sms:false

Pm
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pm
required: sms:false

Sm
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sm
required: sms:false

Eu
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Eu
required: sms:false

Gd
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Gd
required: sms:false

Tb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Tb
required: sms:false

Dy
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Dy
required: sms:false

Ho
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ho
required: sms:false

Er
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Er
required: sms:false

Tm
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Tm
required: sms:false

Yb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Yb
required: sms:false

Lu
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Lu
required: sms:false

Hf
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Hf
required: sms:false

Ta
type: Class
comment: TBD
subclass of: AJCCClinicalT
subclass of: AJCCPathologicT
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ta
required: sms:false

W
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: W
required: sms:false

Re
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Re
required: sms:false

Os
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Os
required: sms:false

Ir
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ir
required: sms:false

Pt
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pt
required: sms:false

Au
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Au
required: sms:false

Hg
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Hg
required: sms:false

Tl
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Tl
required: sms:false

Pb
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pb
required: sms:false

Bi
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Bi
required: sms:false

Po
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Po
required: sms:false

At
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: At
required: sms:false

Rn
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Rn
required: sms:false

Fr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Fr
required: sms:false

Ra
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ra
required: sms:false

Ac
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ac
required: sms:false

Th
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Th
required: sms:false

Pa
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pa
required: sms:false

U
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: U
required: sms:false

Np
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Np
required: sms:false

Pu
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Pu
required: sms:false

Bk
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Bk
required: sms:false

Cf
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cf
required: sms:false

Es
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Es
required: sms:false

Fm
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Fm
required: sms:false

Lr
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Lr
required: sms:false

Rf
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Rf
required: sms:false

Db
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Db
required: sms:false

Sg
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Sg
required: sms:false

Bh
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Bh
required: sms:false

Hs
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Hs
required: sms:false

Mt
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Mt
required: sms:false

Ds
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ds
required: sms:false

Rg
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Rg
required: sms:false

Cn
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Cn
required: sms:false

Nh
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Nh
required: sms:false

Fl
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Fl
required: sms:false

Mc
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Mc
required: sms:false

Lv
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Lv
required: sms:false

Ts
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Ts
required: sms:false

Og
type: Class
comment: TBD
subclass of: MetalIsotopeElement
is part of: schema.biothings.io
display name: Og
required: sms:false

H&E
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: H&E
required: sms:false

CyCIF
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: CyCIF
required: sms:false

T-CyCIF
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: t-CyCIF
required: sms:false

IHC
type: Class
comment: TBD
subclass of: ImagingAssayType
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: IHC
required: sms:false

MIHC
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: mIHC
required: sms:false

MxIF
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: MxIF
required: sms:false

SABER
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: SABER
required: sms:false

IMC
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: IMC
required: sms:false

CODEX
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: CODEX
required: sms:false

GeoMX-DSP
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: GeoMX-DSP
required: sms:false

MIBI
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: MIBI
required: sms:false

MERFISH
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: MERFISH
required: sms:false

ExSeq
type: Class
comment: TBD
subclass of: DataType
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: ExSeq
required: sms:false

RareCyteOrion
type: Class
comment: TBD
subclass of: ImagingAssayType
is part of: schema.biothings.io
display name: RareCyte Orion
required: sms:false

Imaging
type: Class
comment: TBD
subclass of: DataType
is part of: schema.biothings.io
display name: Imaging
required: sms:false

Cm
type: Class
comment: TBD
subclass of: WorkingDistanceUnit
subclass of: FOVXUnit
subclass of: FOVYUnit
subclass of: PhysicalSizeXUnit
subclass of: PhysicalSizeYUnit
subclass of: PhysicalSizeZUnit
subclass of: DimensionsUnit
is part of: schema.biothings.io
display name: cm
required: sms:false

Mm
type: Class
comment: TBD
subclass of: DimensionsUnit
subclass of: WorkingDistanceUnit
subclass of: FOVXUnit
subclass of: FOVYUnit
subclass of: PhysicalSizeXUnit
subclass of: PhysicalSizeYUnit
subclass of: PhysicalSizeZUnit
is part of: schema.biothings.io
display name: mm
required: sms:false

Μm
type: Class
comment: TBD
subclass of: WorkingDistanceUnit
subclass of: FOVXUnit
subclass of: FOVYUnit
subclass of: PhysicalSizeXUnit
subclass of: PhysicalSizeYUnit
subclass of: PhysicalSizeZUnit
is part of: schema.biothings.io
display name: µm
required: sms:false

Nm
type: Class
comment: TBD
subclass of: WorkingDistanceUnit
subclass of: FOVXUnit
subclass of: FOVYUnit
subclass of: PhysicalSizeXUnit
subclass of: PhysicalSizeYUnit
subclass of: PhysicalSizeZUnit
is part of: schema.biothings.io
display name: nm
required: sms:false

Å
type: Class
comment: TBD
subclass of: WorkingDistanceUnit
subclass of: FOVXUnit
subclass of: FOVYUnit
subclass of: PhysicalSizeXUnit
subclass of: PhysicalSizeYUnit
subclass of: PhysicalSizeZUnit
is part of: schema.biothings.io
display name: Å
required: sms:false

Air
type: Class
comment: TBD
subclass of: Immersion
is part of: schema.biothings.io
display name: Air
required: sms:false

Oil
type: Class
comment: TBD
subclass of: Immersion
is part of: schema.biothings.io
display name: Oil
required: sms:false

Water
type: Class
comment: TBD
subclass of: Immersion
is part of: schema.biothings.io
display name: Water
required: sms:false

No-ChannelsQC
type: Class
comment: Not all channels passed QC
subclass of: Imaging
subclass of: PassedQC
is part of: schema.biothings.io
display name: No - Channels QC
required: sms:false
requires dependency: Comment

XYZCT
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: XYZCT
required: sms:false

XYZTC
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: XYZTC
required: sms:false

XYCTZ
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: XYCTZ
required: sms:false

XYCZT
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: XYCZT
required: sms:false

XYTZC
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: XYTZC
required: sms:false

ZYX
type: Class
comment: TBD
subclass of: DimensionOrder
is part of: schema.biothings.io
display name: ZYX
required: sms:false

True
type: Class
comment: TBD
subclass of: PixelsBigEndian
subclass of: PhosphoproteinFlag
subclass of: AgeIsObfuscated
is part of: schema.biothings.io
display name: true
required: sms:false

False
type: Class
comment: TBD
subclass of: PixelsBigEndian
subclass of: PhosphoproteinFlag
subclass of: AgeIsObfuscated
is part of: schema.biothings.io
display name: false
required: sms:false

Int8
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: int8
required: sms:false

Int16
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: int16
required: sms:false

Int32
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: int32
required: sms:false

Uint8
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: uint8
required: sms:false

Uint16
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: uint16
required: sms:false

Uint32
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: uint32
required: sms:false

Float
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: float
required: sms:false

Double
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: double
required: sms:false

Bit
type: Class
comment: TBD
subclass of: PixelType
is part of: schema.biothings.io
display name: bit
required: sms:false

Mask
type: Class
comment: TBD
subclass of: ImagingSegmentationDataType
is part of: schema.biothings.io
display name: Mask
required: sms:false

Outline
type: Class
comment: TBD
subclass of: ImagingSegmentationDataType
is part of: schema.biothings.io
display name: Outline
required: sms:false

Polygon
type: Class
comment: TBD
subclass of: ImagingSegmentationDataType
is part of: schema.biothings.io
display name: Polygon
required: sms:false

ProbabilityMap
type: Class
comment: TBD
subclass of: ImagingSegmentationDataType
is part of: schema.biothings.io
display name: Probability Map
required: sms:false

Point
type: Class
comment: TBD
subclass of: ImagingSegmentationDataType
is part of: schema.biothings.io
display name: Point
required: sms:false

Nucleus
type: Class
comment: TBD
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: nucleus
required: sms:false

Cytoplasm
type: Class
comment: TBD
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: cytoplasm
required: sms:false

Plasmamembrane
type: Class
comment: TBD
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: plasma membrane
required: sms:false

Wholecell
type: Class
comment: TBD
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: whole cell
required: sms:false

Spot
type: Class
comment: TBD
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: spot
required: sms:false

ImagingObjectClassOther
type: Class
comment: Imaging Object Class Other
subclass of: Imaging
subclass of: ImagingObjectClass
is part of: schema.biothings.io
display name: Imaging Object Class Other
required: sms:false
requires dependency: ImagingObjectClassDescription

ImagingObjectClassDescription
type: Class
comment: Free text description of object class [string]
subclass of: Imaging
is part of: schema.biothings.io
display name: Imaging Object Class Description
required: sms:true

Mean
type: Class
comment: TBD
subclass of: ImagingSummaryStatistic
is part of: schema.biothings.io
display name: Mean
required: sms:false

Median
type: Class
comment: TBD
subclass of: ImagingSummaryStatistic
is part of: schema.biothings.io
display name: Median
required: sms:false

NotSpecified
type: Class
comment: TBD
subclass of: ImagingSummaryStatistic
subclass of: PancreaticDuctFinalPathologyType
is part of: schema.biothings.io
display name: Not Specified
required: sms:false

SingleCell
type: Class
comment: TBD
subclass of: NucleicAcidSource
is part of: schema.biothings.io
display name: Single Cell
required: sms:false

BulkWholeCell
type: Class
comment: TBD
subclass of: NucleicAcidSource
is part of: schema.biothings.io
display name: Bulk Whole Cell
required: sms:false

SingleNucleus
type: Class
comment: TBD
subclass of: NucleicAcidSource
is part of: schema.biothings.io
display name: Single Nucleus
required: sms:false

BulkNuclei
type: Class
comment: TBD
subclass of: NucleicAcidSource
is part of: schema.biothings.io
display name: Bulk Nuclei
required: sms:false

Micro-region
type: Class
comment: TBD
subclass of: NucleicAcidSource
is part of: schema.biothings.io
display name: Micro-region
required: sms:false

RarecytePick-Seq
type: Class
comment: TBD
subclass of: Micro-regionSeqPlatform
is part of: schema.biothings.io
display name: Rarecyte Pick-Seq
required: sms:false

LaserCaptureMicrodissection
type: Class
comment: TBD
subclass of: Micro-regionSeqPlatform
is part of: schema.biothings.io
display name: Laser Capture Microdissection
required: sms:false

MicrofluidicsChip
type: Class
comment: TBD
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: Microfluidics Chip
required: sms:false

Droplets
type: Class
comment: TBD
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: Droplets
required: sms:false

FACS
type: Class
comment: TBD
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: FACS
required: sms:false

Plates
type: Class
comment: TBD
subclass of: SingleNucleusCapture
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: Plates
required: sms:false

10x
type: Class
comment: TBD
subclass of: SingleNucleusBuffer
subclass of: SingleNucleusCapture
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: 10x
required: sms:false

NucleiIsolation
type: Class
comment: TBD
subclass of: SingleCellIsolationMethod
is part of: schema.biothings.io
display name: Nuclei Isolation
required: sms:false

GentleMACS
type: Class
comment: TBD
subclass of: DissociationMethod
is part of: schema.biothings.io
display name: gentleMACS
required: sms:false

Dounce
type: Class
comment: TBD
subclass of: DissociationMethod
is part of: schema.biothings.io
display name: Dounce
required: sms:false

EnzymaticDigestion
type: Class
comment: TBD
subclass of: DissociationMethod
is part of: schema.biothings.io
display name: Enzymatic Digestion
required: sms:false

PairedEnd
type: Class
comment: TBD
subclass of: LibraryLayout
is part of: schema.biothings.io
display name: Paired End
required: sms:false

SingleRead
type: Class
comment: TBD
subclass of: LibraryLayout
is part of: schema.biothings.io
display name: Single Read
required: sms:false

Mid-length
type: Class
comment: TBD
subclass of: LibraryLayout
is part of: schema.biothings.io
display name: Mid-length
required: sms:false

LongRead
type: Class
comment: TBD
subclass of: LibraryLayout
is part of: schema.biothings.io
display name: Long Read
required: sms:false

NucleiBarcode
type: Class
comment: Nuclei Barcode
subclass of: ScATAC-seqLevel1
subclass of: NucleusIdentifier
is part of: schema.biothings.io
range includes: NucleiBarcodeRead
range includes: NucleiBarcodeLength
display name: Nuclei Barcode
required: sms:false

ScATACseqPairedEnd
type: Class
comment: A library layout type
subclass of: ScATAC-seqLevel1
subclass of: ScATACseqLibraryLayout
is part of: schema.biothings.io
range includes: ScATACseqRead1
range includes: ScATACseqRead2
display name: scATACseq Paired End
required: sms:false

CellBarcodeandDNAInsert
type: Class
comment: TBD
subclass of: ScATACseqRead1
subclass of: ScATACseqRead2
subclass of: ScATACseqRead3
is part of: schema.biothings.io
display name: Cell Barcode and DNA Insert
required: sms:false

SampleIndexandDNAInsert
type: Class
comment: TBD
subclass of: ScATACseqRead1
subclass of: ScATACseqRead2
subclass of: ScATACseqRead3
is part of: schema.biothings.io
display name: Sample Index and DNA Insert
required: sms:false

DNAInsert
type: Class
comment: TBD
subclass of: ScATACseqRead1
subclass of: ScATACseqRead2
subclass of: ScATACseqRead3
is part of: schema.biothings.io
display name: DNA Insert
required: sms:false

SampleIndex
type: Class
comment: TBD
subclass of: ScATACseqRead1
subclass of: ScATACseqRead2
subclass of: ScATACseqRead3
is part of: schema.biothings.io
display name: Sample Index
required: sms:false

CellBarcode
type: Class
comment: TBD
subclass of: ScATACseqRead1
subclass of: ScATACseqRead2
subclass of: ScATACseqRead3
is part of: schema.biothings.io
display name: Cell Barcode
required: sms:false

CellBarcodeandUMI
type: Class
comment: Cell and transcript identifiers
subclass of: ScRNA-seqLevel1
subclass of: ScmCseqRead1
subclass of: ScmCseqRead2
subclass of: ScmCseqRead3
subclass of: Read1
subclass of: Read2
is part of: schema.biothings.io
display name: Cell Barcode and UMI
required: sms:false
requires dependency: UMIBarcodeOffset
requires dependency: UMIBarcodeLength
requires dependency: MedianUMIsperCellNumber
requires dependency: CellBarcodeOffset
requires dependency: CellBarcodeLength
requires dependency: ValidBarcodesCellNumber

R1
type: Class
comment: TBD
subclass of: ReadIndicator
subclass of: ResidualDisease
is part of: schema.biothings.io
display name: R1
required: sms:false

R2
type: Class
comment: TBD
subclass of: ReadIndicator
subclass of: ResidualDisease
is part of: schema.biothings.io
display name: R2
required: sms:false

R1&R2
type: Class
comment: TBD
subclass of: ReadIndicator
is part of: schema.biothings.io
display name: R1&R2
required: sms:false

I1
type: Class
comment: TBD
subclass of: ReadIndicator
is part of: schema.biothings.io
display name: I1
required: sms:false

CDNAOffset
type: Class
comment: Offset in sequence for cDNA read (in bp): number
subclass of: Sequencing
is part of: schema.biothings.io
display name: cDNA Offset
required: sms:true

CDNALength
type: Class
comment: Length of cDNA read (in bp): number
subclass of: Sequencing
is part of: schema.biothings.io
display name: cDNA Length
required: sms:true

MedianUMIsperCellNumber
type: Class
comment: Number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Median UMIs per Cell Number
required: sms:true

CellBarcodeOffset
type: Class
comment: Offset in sequence for cell barcode read (in bp): number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Cell Barcode Offset
required: sms:true

CellBarcodeLength
type: Class
comment: Length of cell barcode read (in bp): number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Cell Barcode Length
required: sms:true

ValidBarcodesCellNumber
type: Class
comment: Number
subclass of: ScRNA-seqLevel1
is part of: schema.biothings.io
display name: Valid Barcodes Cell Number
required: sms:true

CEL-seq2
type: Class
comment: Highly-multiplexed plate-based single-cell RNA-Seq assay
subclass of: ScRNA-seqLevel1
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: CEL-seq2
required: sms:false
requires dependency: EmptyWellBarcode
requires dependency: WellIndex

Sci-ATAC-seq
type: Class
comment: TBD
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: sci-ATAC-seq
required: sms:false

10xMultiome
type: Class
comment: TBD
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10x Multiome
required: sms:false

10xFLEX
type: Class
comment: TBD
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10x FLEX
required: sms:false

10xGEM3'
type: Class
comment: TBD
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10x GEM 3'
required: sms:false

10xGEM5'
type: Class
comment: TBD
subclass of: LibraryConstructionMethod
is part of: schema.biothings.io
display name: 10x GEM 5'
required: sms:false

3Prime
type: Class
comment: TBD
subclass of: EndBias
is part of: schema.biothings.io
display name: 3 Prime
required: sms:false

5Prime
type: Class
comment: TBD
subclass of: EndBias
is part of: schema.biothings.io
display name: 5 Prime
required: sms:false

FullLengthTranscript
type: Class
comment: TBD
subclass of: EndBias
is part of: schema.biothings.io
display name: Full Length Transcript
required: sms:false

Poly-dT
type: Class
comment: TBD
subclass of: ReverseTranscriptionPrimer
is part of: schema.biothings.io
display name: Poly-dT
required: sms:false

Featurebarcoding
type: Class
comment: A method for adding extra channels of information to cells by running single-cell gene expression in parallel with other assays [https://support.10xgenomics.com/single-cell-gene-expression/software/pipelines/latest/feature-bc]
subclass of: ScRNA-seqLevel1
subclass of: ReverseTranscriptionPrimer
is part of: schema.biothings.io
display name: Feature barcoding
required: sms:false
requires dependency: FeatureReferenceId

Random
type: Class
comment: TBD
subclass of: ReverseTranscriptionPrimer
subclass of: LibrarySelectionMethod
is part of: schema.biothings.io
display name: Random
required: sms:false

ERCC
type: Class
comment: The External RNA Controls Consortium (ERCC) spike in set is commonly used in single-cell experiments for normalization
subclass of: SpikeIn
is part of: schema.biothings.io
display name: ERCC
required: sms:false
requires dependency: SpikeInConcentration

OtherSpikeIn
type: Class
comment: TBD
subclass of: SpikeIn
is part of: schema.biothings.io
display name: Other Spike In
required: sms:false

NoSpikeIn
type: Class
comment: TBD
subclass of: SpikeIn
is part of: schema.biothings.io
display name: No Spike In
required: sms:false

PhiX
type: Class
comment: TBD
subclass of: SpikeIn
is part of: schema.biothings.io
display name: PhiX
required: sms:false

IlluminaNextSeq500
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina Next Seq 500
required: sms:false

IlluminaNextSeq550
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina Next Seq 550
required: sms:false

IlluminaNextSeq2500
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina Next Seq 2500
required: sms:false

ABSOLiD4
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: AB SOLiD 4
required: sms:false

ABSOLiD2
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: AB SOLiD 2
required: sms:false

ABSOLiD3
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: AB SOLiD 3
required: sms:false

IlluminaHiSeqXTen
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina HiSeq X Ten
required: sms:false

IlluminaHiSeqXFive
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina HiSeq X Five
required: sms:false

IlluminaNextSeq
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina NextSeq
required: sms:false

NovaSeq6000
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: NovaSeq 6000
required: sms:false

NovaSeqS4
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: NovaSeqS4
required: sms:false

UltimaGenomicsUG100
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Ultima Genomics UG100
required: sms:false

OxfordNanoporeminION
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Oxford Nanopore minION
required: sms:false

PacBioSequel2
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: PacBio Sequel2
required: sms:false

Revio
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Revio
required: sms:false

IlluminaNextSeq1000
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina NextSeq 1000
required: sms:false

IlluminaNextSeq2000
type: Class
comment: TBD
subclass of: SequencingPlatform
is part of: schema.biothings.io
display name: Illumina NextSeq 2000
required: sms:false

Unknown
type: Class
comment: TBD
subclass of: SmokeExposureDuration
subclass of: FusionGeneDetected
subclass of: Ethnicity
subclass of: Gender
subclass of: VitalStatus
subclass of: PrematureAtBirth
subclass of: RelationshipGender
subclass of: RelativewithCancerHistory
subclass of: AlcoholHistory
subclass of: AsbestosExposure
subclass of: CoalDustExposure
subclass of: EnvironmentalTobaccoSmokeExposure
subclass of: RadonExposure
subclass of: RespirableCrystallineSilicaExposure
subclass of: SmokingFrequency
subclass of: SecondhandSmokeasChild
subclass of: HepatitisSustainedVirologicalResponse
subclass of: HAARTTreatmentIndicator
subclass of: ProgressionorRecurrence
subclass of: RiskFactorTreatment
subclass of: TreatmentorTherapy
subclass of: ChemoConcurrenttoRadiation
subclass of: SatelliteMetastasisPresentIndicator
subclass of: Immunosuppression
subclass of: FamilyMemberVitalStatusIndicator
subclass of: COVID19OccurrenceIndicator
subclass of: COVID19PositiveLabTestIndicator
subclass of: COVID19CancerTreatmentFollowup
subclass of: KnownGeneticPredispositionMutation
subclass of: MismatchRepairMutation
subclass of: VariantOrigin
subclass of: INPCHistologicGroup
subclass of: MicropapillaryFeatures
subclass of: NonNodalTumorDeposits
subclass of: PregnantatDiagnosis
subclass of: PriorMalignancy
subclass of: PriorTreatment
subclass of: AnaplasiaPresent
subclass of: LymphaticInvasionPresent
subclass of: PerineuralInvasionPresent
subclass of: SynchronousMalignancy
subclass of: TumorConfinedtoOrganofOrigin
subclass of: TumorFocality
subclass of: VascularInvasionPresent
subclass of: ImmediateFamilyHistoryEndometrialCancer
subclass of: ImmediateFamilyHistoryOvarianCancer
subclass of: ColorectalCancerKRASIndicator
subclass of: ColonPolypOccurenceIndicator
subclass of: FamilyHistoryColorectalPolyp
subclass of: ColorectalPolypNewIndicator
subclass of: HormoneTherapyBreastCancerPreventionIndicator
subclass of: MultifocalBreastCarcinomaPresentIndicator
subclass of: MulticentricBreastCarcinomaPresentIndicator
subclass of: GliomaSpecificRadiationField
subclass of: SupraTentorialEpendymomaMolecularSubgroup
subclass of: NCIALLRiskGroup
subclass of: ProstateCancerLocalExtent
subclass of: CutaneousMelanomaSurgicalMargins
subclass of: HistoryofBlisteringSunburn
subclass of: ImmediateFamilyHistoryMelanoma
subclass of: CutaneousMelanomaUlceration
subclass of: AdapterContent
subclass of: BasicStatistics
subclass of: KmerContent
subclass of: OverrepresentedSequences
subclass of: PerBaseNContent
subclass of: PerBaseSequenceContent
subclass of: PerBaseSequenceQuality
subclass of: PerSequenceGCContent
subclass of: PerSequenceQualityScore
subclass of: PerTileSequenceQuality
subclass of: SequenceDuplicationLevels
subclass of: SequenceLengthDistribution
subclass of: SpecimenLaterality
subclass of: HistologyAssessmentBy
subclass of: HistologyAssessmentMedium
subclass of: ComorbidityMethodofDiagnosis

NotReported
type: Class
comment: TBD
subclass of: SmokingExposure
subclass of: AlcoholExposure
subclass of: SmokeExposureDuration
subclass of: TreatmentEffectIndicator
subclass of: PrecancerCase
subclass of: Ethnicity
subclass of: VitalStatus
subclass of: PrematureAtBirth
subclass of: RelativewithCancerHistory
subclass of: AlcoholHistory
subclass of: AsbestosExposure
subclass of: RadonExposure
subclass of: SecondhandSmokeasChild
subclass of: HepatitisSustainedVirologicalResponse
subclass of: HAARTTreatmentIndicator
subclass of: ProgressionorRecurrence
subclass of: RiskFactorTreatment
subclass of: TreatmentorTherapy
subclass of: ChemoConcurrenttoRadiation
subclass of: FamilyMemberVitalStatusIndicator
subclass of: MismatchRepairMutation
subclass of: INPCHistologicGroup
subclass of: ISSStage
subclass of: MicropapillaryFeatures
subclass of: NonNodalTumorDeposits
subclass of: PregnantatDiagnosis
subclass of: PriorMalignancy
subclass of: PriorTreatment
subclass of: AnaplasiaPresent
subclass of: LymphaticInvasionPresent
subclass of: PerineuralInvasionPresent
subclass of: SynchronousMalignancy
subclass of: TumorConfinedtoOrganofOrigin
subclass of: TumorFocality
subclass of: VascularInvasionPresent
subclass of: ProstateCancerLocalExtent
subclass of: CutaneousMelanomaSurgicalMargins
subclass of: HistoryofBlisteringSunburn
subclass of: CutaneousMelanomaUlceration
subclass of: AdapterContent
subclass of: BasicStatistics
subclass of: KmerContent
subclass of: OverrepresentedSequences
subclass of: PerBaseNContent
subclass of: PerBaseSequenceContent
subclass of: PerBaseSequenceQuality
subclass of: PerSequenceGCContent
subclass of: PerSequenceQualityScore
subclass of: PerTileSequenceQuality
subclass of: SequenceDuplicationLevels
subclass of: SequenceLengthDistribution
subclass of: SpecimenLaterality
subclass of: Gender
subclass of: RelationshipGender
subclass of: ComorbidityMethodofDiagnosis
subclass of: MenopauseStatus
subclass of: HormonalContraceptiveUse
subclass of: TreatmentEffect
subclass of: CogNeuroblastomaRiskGroup
subclass of: CogRhabdomyosarcomaRiskGroup
subclass of: IGCCCGStage
subclass of: INPCGrade
subclass of: MitosisKaryorrhexisIndex
subclass of: NonNodalRegionalDisease
subclass of: OvarianSpecimenStatus
subclass of: OvarianSurfaceInvolvement
subclass of: LungTumorLocationAnatomicSite
subclass of: SarcomaDiagnosisClassificationCategory
subclass of: HistoryofAtypicalNevi
subclass of: HistoryofChronicUVExposure
subclass of: AlcoholType
subclass of: HysterectomyType
subclass of: ImagingResult
subclass of: ProgressionorRecurrenceType
subclass of: RefluxTreatmentType
subclass of: InitialDiseaseStatus
subclass of: Zygosity

NIB
type: Class
comment: TBD
subclass of: SingleNucleusBuffer
is part of: schema.biothings.io
display name: NIB
required: sms:false

Omni
type: Class
comment: TBD
subclass of: SingleNucleusBuffer
is part of: schema.biothings.io
display name: Omni
required: sms:false

TST
type: Class
comment: TBD
subclass of: SingleNucleusBuffer
is part of: schema.biothings.io
display name: TST
required: sms:false

Tn5
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: Tn5
required: sms:false

EZ-Tn5
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: EZ-Tn5
required: sms:false

Tn5-059
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: Tn5-059
required: sms:false

NexteraTn5
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: Nextera Tn5
required: sms:false

Diagenode-unloadedApex-Bio
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: Diagenode-unloaded Apex-Bio
required: sms:false

Diagenode-loadedApex-Bio
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: Diagenode-loaded Apex-Bio
required: sms:false

In-House
type: Class
comment: TBD
subclass of: TranspositionReaction
is part of: schema.biothings.io
display name: In-House
required: sms:false

CustomTargetsFileProvided
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Targets File Provided
required: sms:false

CustomAmpliSeqCancerHotspotGENIE-MDAAugmentedPanelv1-46Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom AmpliSeq Cancer Hotspot GENIE-MDA Augmented Panel v1 - 46 Genes
required: sms:false

CustomGENIE-DFCIOncoPanel-275Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom GENIE-DFCI OncoPanel - 275 Genes
required: sms:false

CustomGENIE-DFCIOncopanel-300Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom GENIE-DFCI Oncopanel - 300 Genes
required: sms:false

CustomGENIE-DFCIOncopanel-447Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom GENIE-DFCI Oncopanel - 447 Genes
required: sms:false

CustomHaloPlexDLBCLPanel-370Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom HaloPlex DLBCL Panel - 370 Genes
required: sms:false

http://schema.biothings.io/CustomIonAmpliSeqHotspotGENIE-MOSC3AugmentedPanel-74Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Ion AmpliSeq Hotspot GENIE-MOSC3 Augmented Panel - 74 Genes
required: sms:false

CustomLargeConstructCaptureTARGET-OSPanel-8Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Large Construct Capture TARGET-OS Panel - 8 Genes
required: sms:false

CustomMSKIMPACTPanel-341Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom MSK IMPACT Panel - 341 Genes
required: sms:false

CustomMSKIMPACTPanel-410Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom MSK IMPACT Panel - 410 Genes
required: sms:false

CustomMSKIMPACTPanel-468Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom MSK IMPACT Panel - 468 Genes
required: sms:false

CustomMyeloidGENIE-VICCPanel-37Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Myeloid GENIE-VICC Panel - 37 Genes
required: sms:false

CustomPersonalisACEcpVAREPOP-APOLLOPanelv2
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Personalis ACEcp VAREPOP-APOLLO Panel v2
required: sms:false

CustomPGDXSureSelectCancerSelectVAREPOP-APOLLOPanel-203Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom PGDX SureSelect CancerSelect VAREPOP-APOLLO Panel - 203 Genes
required: sms:false

CustomPGDXSureSelectCancerSelectVAREPOP-APOLLOPanel-88Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom PGDX SureSelect CancerSelect VAREPOP-APOLLO Panel - 88 Genes
required: sms:false

http://schema.biothings.io/CustomSeqCapEZHGSCVCRomev2.1ERAugmentedv1
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SeqCap EZ HGSC VCRome v2.1 ER Augmented v1
required: sms:false

http://schema.biothings.io/CustomSeqCapEZHGSCVCRomev2.1ERAugmentedv2
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SeqCap EZ HGSC VCRome v2.1 ER Augmented v2
required: sms:false

CustomSeqCapEZTARGET-OSPanel-7.0Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SeqCap EZ TARGET-OS Panel - 7.0 Mb
required: sms:false

CustomSolidTumorGENIE-VICCPanel-34Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Solid Tumor GENIE-VICC Panel - 34 Genes
required: sms:false

CustomSureSelectCGCI-BLGSPPanel-4.6Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect CGCI-BLGSP Panel - 4.6 Mb
required: sms:false

http://schema.biothings.io/CustomSureSelectCGCI-HTMCP-CCKMT2DAndHotspotPanel-37.0Kb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect CGCI-HTMCP-CC KMT2D And Hotspot Panel - 37.0 Kb
required: sms:false

CustomSureSelectCGCI-HTMCP-CCPanel-19.7Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect CGCI-HTMCP-CC Panel - 19.7 Mb
required: sms:false

CustomSureSelectGENIE-UHNPanel-555Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect GENIE-UHN Panel - 555 Genes
required: sms:false

http://schema.biothings.io/CustomSureSelectHumanAllExonv1.1Plus3Boosters
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect Human All Exon v1.1 Plus 3 Boosters
required: sms:false

CustomSureSelectTARGET-AMLNBLWTPanel-2.8Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom SureSelect TARGET-AML_NBL_WT Panel - 2.8 Mb
required: sms:false

CustomTwistBroadExomev1.0-35.0Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Twist Broad Exome v1.0 - 35.0 Mb
required: sms:false

CustomTwistBroadPanCancerPanel-396Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Custom Twist Broad PanCancer Panel - 396 Genes
required: sms:false

FoundationMedicineT5aPanel-322Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Foundation Medicine T5a Panel - 322 Genes
required: sms:false

FoundationMedicineT7Panel-429Genes
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Foundation Medicine T7 Panel - 429 Genes
required: sms:false

IonAmpliSeqCancerHotspotPanelv2
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Ion AmpliSeq Cancer Hotspot Panel v2
required: sms:false

IonAmpliSeqComprehensiveCancerPanel
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Ion AmpliSeq Comprehensive Cancer Panel
required: sms:false

NexteraDNAExome
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Nextera DNA Exome
required: sms:false

NexteraRapidCaptureExomev1.2
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: Nextera Rapid Capture Exome v1.2
required: sms:false

SeqCapEZHGSCVCRomev2.1
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SeqCap EZ HGSC VCRome v2.1
required: sms:false

SeqCapEZHumanExomev2.0
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SeqCap EZ Human Exome v2.0
required: sms:false

SeqCapEZHumanExomev3.0
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SeqCap EZ Human Exome v3.0
required: sms:false

SureSelectHumanAllExonv3
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SureSelect Human All Exon v3
required: sms:false

SureSelectHumanAllExonv4
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SureSelect Human All Exon v4
required: sms:false

SureSelectHumanAllExonv5
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SureSelect Human All Exon v5
required: sms:false

SureSelectHumanAllExonv5+UTR
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SureSelect Human All Exon v5 + UTR
required: sms:false

TruSeqAmpliconCancerPanel
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: TruSeq Amplicon Cancer Panel
required: sms:false

TruSeqExomeEnrichment-62Mb
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: TruSeq Exome Enrichment - 62 Mb
required: sms:false

TruSeqRNAExome
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: TruSeq RNA Exome
required: sms:false

TruSightMyeloidSequencingPanel
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: TruSight Myeloid Sequencing Panel
required: sms:false

XGenExomeResearchPanelv1.0
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: xGen Exome Research Panel v1.0
required: sms:false

XGenUniversalBlockingOligo–TSHT-i5-25rxn
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: xGen Universal Blocking Oligo – TS HT-i5 - 25 rxn
required: sms:false

25rxnxGenUniversalBlockingOligo–TSHT-i7
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: 25 rxn xGen Universal Blocking Oligo – TS HT-i7
required: sms:false

SureSelectHumanAllExonv6
type: Class
comment: TBD
subclass of: TargetCaptureKit
is part of: schema.biothings.io
display name: SureSelect Human All Exon v6
required: sms:false

AffinityEnrichment
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
is part of: schema.biothings.io
display name: Affinity Enrichment
required: sms:false

Poly-TEnrichment
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
is part of: schema.biothings.io
display name: Poly-T Enrichment
required: sms:false

RRNADepletion
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
is part of: schema.biothings.io
display name: rRNA Depletion
required: sms:false

MiRNASizeFractionation
type: Class
comment: TBD
subclass of: LibrarySelectionMethod
is part of: schema.biothings.io
display name: miRNA Size Fractionation
required: sms:false

Unstranded
type: Class
comment: TBD
subclass of: LibraryStrand
is part of: schema.biothings.io
display name: Unstranded
required: sms:false

FirstStranded
type: Class
comment: TBD
subclass of: LibraryStrand
is part of: schema.biothings.io
display name: First Stranded
required: sms:false

SecondStranded
type: Class
comment: TBD
subclass of: LibraryStrand
is part of: schema.biothings.io
display name: Second Stranded
required: sms:false

Yes-TrimAdapterSequence
type: Class
comment: Trim adapter sequence
subclass of: Sequencing
subclass of: ToTrimAdapterSequence
is part of: schema.biothings.io
range includes: AdapterTrimmerName
range includes: AdapterTrimmerVersion
range includes: AdapterTrimmerOptions
display name: Yes - Trim Adapter Sequence
required: sms:false

AdapterTrimmerName
type: Class
comment: Name of adapter trimmer
subclass of: Sequencing
subclass of: Yes-TrimAdapterSequence
is part of: schema.biothings.io
display name: Adapter Trimmer Name
required: sms:false

AdapterTrimmerVersion
type: Class
comment: Version of the adapter trimmer
subclass of: Sequencing
subclass of: Yes-TrimAdapterSequence
is part of: schema.biothings.io
display name: Adapter Trimmer Version
required: sms:false

AdapterTrimmerOptions
type: Class
comment: Options used by adapter trimmer
subclass of: Sequencing
subclass of: Yes-TrimAdapterSequence
is part of: schema.biothings.io
display name: Adapter Trimmer Options
required: sms:false

FAIL
type: Class
comment: TBD
subclass of: AdapterContent
subclass of: BasicStatistics
subclass of: KmerContent
subclass of: OverrepresentedSequences
subclass of: PerBaseNContent
subclass of: PerBaseSequenceContent
subclass of: PerBaseSequenceQuality
subclass of: PerSequenceGCContent
subclass of: PerSequenceQualityScore
subclass of: PerTileSequenceQuality
subclass of: SequenceDuplicationLevels
subclass of: SequenceLengthDistribution
is part of: schema.biothings.io
display name: FAIL
required: sms:false

PASS
type: Class
comment: TBD
subclass of: AdapterContent
subclass of: BasicStatistics
subclass of: KmerContent
subclass of: OverrepresentedSequences
subclass of: PerBaseNContent
subclass of: PerBaseSequenceContent
subclass of: PerBaseSequenceQuality
subclass of: PerSequenceGCContent
subclass of: PerSequenceQualityScore
subclass of: PerTileSequenceQuality
subclass of: SequenceDuplicationLevels
subclass of: SequenceLengthDistribution
is part of: schema.biothings.io
display name: PASS
required: sms:false

WARN
type: Class
comment: TBD
subclass of: AdapterContent
subclass of: BasicStatistics
subclass of: KmerContent
subclass of: OverrepresentedSequences
subclass of: PerBaseNContent
subclass of: PerBaseSequenceContent
subclass of: PerBaseSequenceQuality
subclass of: PerSequenceGCContent
subclass of: PerSequenceQualityScore
subclass of: PerTileSequenceQuality
subclass of: SequenceDuplicationLevels
subclass of: SequenceLengthDistribution
is part of: schema.biothings.io
display name: WARN
required: sms:false

Yes-AppliedHardTrimming
type: Class
comment: Hard Trimming was applied
subclass of: Sequencing
subclass of: AppliedHardTrimming
is part of: schema.biothings.io
display name: Yes - Applied Hard Trimming
required: sms:false
requires dependency: AlignedReadLength

CellRanger
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: CellRanger
required: sms:false

STARsolo
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: STARsolo
required: sms:false

HCAOptimus
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: HCA Optimus
required: sms:false

DropEST
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: dropEST
required: sms:false

SEQC
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: SEQC
required: sms:false

Cufflinks
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: Cufflinks
required: sms:false

DEXSeq
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: DEXSeq
required: sms:false

HTSeq-FPKM
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: HTSeq - FPKM
required: sms:false

Cellannotation
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: Cell annotation
required: sms:false

Differentiationtrajectoryanalysis
type: Class
comment: TBD
subclass of: ScRNAseqWorkflowType
is part of: schema.biothings.io
display name: Differentiation trajectory analysis
required: sms:false

GATK4
type: Class
comment: TBD
subclass of: GermlineVariantsWorkflowType
subclass of: SomaticVariantsWorkflowType
subclass of: StructuralVariantWorkflowType
is part of: schema.biothings.io
display name: GATK4
required: sms:false

OtherGermlineVariantsWorkflowType
type: Class
comment: Other Germline Variants Workflow Type
subclass of: Sequencing
subclass of: GermlineVariantsWorkflowType
is part of: schema.biothings.io
display name: Other Germline Variants Workflow Type
required: sms:false
requires dependency: CustomGermlineVariantsWorkflowType

None
type: Class
comment: TBD
subclass of: SeminalVesicleInvasion
subclass of: EMsignalprocessing
subclass of: RelativewithCancerHistory
subclass of: GermlineVariantsWorkflowType
subclass of: HysterectomyMarginsInvolved
subclass of: HistoryofChronicUVExposure
subclass of: CDCHIVRiskFactors
subclass of: ImmunosuppressiveTreatmentType
subclass of: PancreaticDuctFinalPathologyType
subclass of: Pre-processingCompleted
subclass of: Pre-processingRequired
subclass of: StructuralVariantWorkflowType
subclass of: CollectionMedia
subclass of: SomaticVariantsWorkflowType
subclass of: LymphNodeInvolvedSite
subclass of: FixativeType
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: None
required: sms:false

CustomGermlineVariantsWorkflowType
type: Class
comment: Specify the name of a custom alignment workflow
subclass of: Sequencing
is part of: schema.biothings.io
display name: Custom Germline Variants Workflow Type
required: sms:true

CaVEMan
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: CaVEMan
required: sms:false

MuTect2
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: MuTect2
required: sms:false

MuSE
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: MuSE
required: sms:false

Pindel
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: Pindel
required: sms:false

SomaticSniper
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: SomaticSniper
required: sms:false

VarScan2
type: Class
comment: TBD
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: VarScan2
required: sms:false

OtherSomaticVariantsWorkflowType
type: Class
comment: Other Somatic Variants Workflow Type
subclass of: Sequencing
subclass of: SomaticVariantsWorkflowType
is part of: schema.biothings.io
display name: Other Somatic Variants Workflow Type
required: sms:false
requires dependency: CustomSomaticVariantsWorkflowType

CustomSomaticVariantsWorkflowType
type: Class
comment: Specify the name of a custom workflow name
subclass of: Sequencing
is part of: schema.biothings.io
display name: Custom Somatic Variants Workflow Type
required: sms:true

CaseSample
type: Class
comment: TBD
subclass of: SomaticVariantsSampleType
is part of: schema.biothings.io
display name: Case Sample
required: sms:false

ControlSample
type: Class
comment: TBD
subclass of: SomaticVariantsSampleType
is part of: schema.biothings.io
display name: Control Sample
required: sms:false

BRASS
type: Class
comment: TBD
subclass of: StructuralVariantWorkflowType
is part of: schema.biothings.io
display name: BRASS
required: sms:false

CNV
type: Class
comment: TBD
subclass of: StructuralVariantWorkflowType
is part of: schema.biothings.io
display name: CNV
required: sms:false

CNVkit
type: Class
comment: TBD
subclass of: StructuralVariantWorkflowType
is part of: schema.biothings.io
display name: CNVkit
required: sms:false

OtherStructuralVariantWorkflowType
type: Class
comment: Other Structural Variant Workflow Type
subclass of: Sequencing
subclass of: StructuralVariantWorkflowType
is part of: schema.biothings.io
display name: Other Structural Variant Workflow Type
required: sms:false
requires dependency: CustomStructuralVariantWorkflowType

CustomStructuralVariantWorkflowType
type: Class
comment: Specify the name of a custom workflow name
subclass of: Sequencing
is part of: schema.biothings.io
display name: Custom Structural Variant Workflow Type
required: sms:true

BWA
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA
required: sms:false

BWAwithBQSR
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA with BQSR
required: sms:false

BWA-aln
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA-aln
required: sms:false

BWA-mem
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA-mem
required: sms:false

BWAwithMarkDuplicatesandBQSR
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA with Mark Duplicates and BQSR
required: sms:false

STAR2-Pass
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: STAR 2-Pass
required: sms:false

STAR2-PassChimeric
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: STAR 2-Pass Chimeric
required: sms:false

STAR2-PassGenome
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: STAR 2-Pass Genome
required: sms:false

STAR2-PassTranscriptome
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: STAR 2-Pass Transcriptome
required: sms:false

Bowtie
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Bowtie
required: sms:false

Bismark
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Bismark
required: sms:false

GSNAP
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: GSNAP
required: sms:false

BSMAP
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BSMAP
required: sms:false

BSmooth
type: Class
comment: TBD
subclass of: DMCCallingTool
subclass of: DMRCallingTool
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BSmooth
required: sms:false

BS-Seeker2
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BS-Seeker2
required: sms:false

BS-Seeker
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BS-Seeker
required: sms:false

RMAP
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: RMAP
required: sms:false

MethylCoder
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: MethylCoder
required: sms:false

BRAT-BW
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BRAT-BW
required: sms:false

Pash
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Pash
required: sms:false

Segemehl
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Segemehl
required: sms:false

Bisulfighter
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Bisulfighter
required: sms:false

BatMeth
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BatMeth
required: sms:false

LAST
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: LAST
required: sms:false

ERNE-BS5
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: ERNE-BS5
required: sms:false

B-SOLANA
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: B-SOLANA
required: sms:false

SOCS-B
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: SOCS-B
required: sms:false

BWA-meth
type: Class
comment: TBD
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: BWA-meth
required: sms:false

OtherAlignmentWorkflow
type: Class
comment: Other Alignment Workflow
subclass of: Sequencing
subclass of: AlignmentWorkflowType
is part of: schema.biothings.io
display name: Other Alignment Workflow
required: sms:false
requires dependency: CustomAlignmentWorkflow

CustomAlignmentWorkflow
type: Class
comment: Specify the name of a custom alignment workflow
subclass of: Sequencing
is part of: schema.biothings.io
display name: Custom Alignment Workflow
required: sms:true

MSI
type: Class
comment: TBD
subclass of: MSIStatus
is part of: schema.biothings.io
display name: MSI
required: sms:false

MSI-low
type: Class
comment: TBD
subclass of: MSIStatus
is part of: schema.biothings.io
display name: MSI-low
required: sms:false

MSI-high
type: Class
comment: TBD
subclass of: MSIStatus
is part of: schema.biothings.io
display name: MSI-high
required: sms:false

MSS
type: Class
comment: TBD
subclass of: MSIStatus
is part of: schema.biothings.io
display name: MSS
required: sms:false

Yes-PseudoAlignmentUsed
type: Class
comment: Pseudo aligner was used
subclass of: Sequencing
subclass of: PseudoAlignmentUsed
is part of: schema.biothings.io
display name: Yes - Pseudo Alignment Used
required: sms:false
requires dependency: WorkflowLink
requires dependency: SoftwareandVersion
requires dependency: GenomicReference
requires dependency: GenomicReferenceURL

GeneExpression
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Gene Expression
required: sms:false

TranscriptExpression
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Transcript Expression
required: sms:false

ExonExpressionQuantification
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Exon Expression Quantification
required: sms:false

GeneExpressionQuantification
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Gene Expression Quantification
required: sms:false

IsoformExpressionQuantification
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Isoform Expression Quantification
required: sms:false

SpliceJunctionQuantification
type: Class
comment: TBD
subclass of: DataCategory
is part of: schema.biothings.io
display name: Splice Junction Quantification
required: sms:false

TPM
type: Class
comment: TBD
subclass of: ExpressionUnits
is part of: schema.biothings.io
display name: TPM
required: sms:false

RPKM
type: Class
comment: TBD
subclass of: ExpressionUnits
is part of: schema.biothings.io
display name: RPKM
required: sms:false

FPKM
type: Class
comment: TBD
subclass of: ExpressionUnits
is part of: schema.biothings.io
display name: FPKM
required: sms:false

Counts
type: Class
comment: TBD
subclass of: ExpressionUnits
is part of: schema.biothings.io
display name: Counts
required: sms:false

NA
type: Class
comment: TBD
subclass of: ExpressionUnits
is part of: schema.biothings.io
display name: NA
required: sms:false

Yes-FusionGeneDetected
type: Class
comment: A fusion gene was detected
subclass of: Sequencing
subclass of: FusionGeneDetected
is part of: schema.biothings.io
display name: Yes - Fusion Gene Detected
required: sms:false
requires dependency: FusionGeneIdentity

EWS-FLI
type: Class
comment: TBD
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: EWS-FLI
required: sms:false

EWS-ERG
type: Class
comment: TBD
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: EWS-ERG
required: sms:false

SYT-SSX1
type: Class
comment: TBD
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: SYT-SSX1
required: sms:false

SYT-SSX2
type: Class
comment: TBD
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: SYT-SSX2
required: sms:false

EWS-WT1
type: Class
comment: TBD
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: EWS-WT1
required: sms:false

OtherFusionGene
type: Class
comment: Other fusion gene detected.
subclass of: Sequencing
subclass of: FusionGeneIdentity
is part of: schema.biothings.io
display name: Other Fusion Gene
required: sms:false
requires dependency: SpecifyOtherFusionGene

SpecifyOtherFusionGene
type: Class
comment: Specify fusion gene detected, if not in list
subclass of: Sequencing
is part of: schema.biothings.io
display name: Specify Other Fusion Gene
required: sms:false

RawCounts
type: Class
comment: TBD
subclass of: MatrixType
is part of: schema.biothings.io
display name: Raw Counts
required: sms:false

NormalizedCounts
type: Class
comment: TBD
subclass of: MatrixType
is part of: schema.biothings.io
display name: Normalized Counts
required: sms:false

ScaledCounts
type: Class
comment: TBD
subclass of: MatrixType
is part of: schema.biothings.io
display name: Scaled Counts
required: sms:false

BatchCorrectedCounts
type: Class
comment: TBD
subclass of: MatrixType
is part of: schema.biothings.io
display name: Batch Corrected Counts
required: sms:false

TissueBiospecimenType
type: Class
comment: Tissue biospecimen
subclass of: Biospecimen
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Tissue Biospecimen Type
required: sms:false
requires dependency: IschemicTime
requires dependency: IschemicTemperature
requires dependency: SiteofResectionorBiopsy
requires dependency: SpecimenLaterality
requires dependency: PortionWeight
requires dependency: TotalVolume
requires dependency: TumorTissueType
requires dependency: HistologicMorphologyCode
requires dependency: PreservationMethod
requires dependency: BiospecimenDimension1
requires dependency: BiospecimenDimension2
requires dependency: BiospecimenDimension3
requires dependency: SectionNumberinSequence

BloodBiospecimenType
type: Class
comment: Blood biospecimen
subclass of: Biospecimen
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Blood Biospecimen Type
required: sms:false
requires dependency: ShippingConditionType

AnalyteBiospecimenType
type: Class
comment: A molecular derivative (I.e. RNA / DNA / Protein Lysate) obtained from a specimen
subclass of: Biospecimen
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Analyte Biospecimen Type
required: sms:false
requires dependency: AnalyteType
requires dependency: FixationDuration
requires dependency: SlideChargeType
requires dependency: SectionThicknessValue
requires dependency: SectioningDaysfromIndex
requires dependency: ShippingConditionType
requires dependency: IschemicTime
requires dependency: IschemicTemperature

MouthRinseBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Mouth Rinse Biospecimen Type
required: sms:false

StoolBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Stool Biospecimen Type
required: sms:false

UrineBiospecimenType
type: Class
comment: Urine biospecimen
subclass of: Biospecimen
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Urine Biospecimen Type
required: sms:false
requires dependency: IschemicTime
requires dependency: IschemicTemperature
requires dependency: SiteofResectionorBiopsy
requires dependency: SpecimenLaterality
requires dependency: PortionWeight
requires dependency: TotalVolume
requires dependency: TumorTissueType
requires dependency: HistologicMorphologyCode
requires dependency: PreservationMethod

AscitesBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Ascites Biospecimen Type
required: sms:false

SputumBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Sputum Biospecimen Type
required: sms:false

FluidsBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Fluids Biospecimen Type
required: sms:false

BoneMarrowBiospecimenType
type: Class
comment: Bone Marrow biospecimen
subclass of: Biospecimen
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Bone Marrow Biospecimen Type
required: sms:false
requires dependency: IschemicTime
requires dependency: IschemicTemperature
requires dependency: SiteofResectionorBiopsy
requires dependency: SpecimenLaterality
requires dependency: PortionWeight
requires dependency: TotalVolume
requires dependency: TumorTissueType
requires dependency: HistologicMorphologyCode
requires dependency: PreservationMethod
requires dependency: BiospecimenDimension1
requires dependency: BiospecimenDimension2
requires dependency: BiospecimenDimension3
requires dependency: SectionNumberinSequence

CellsBiospecimenType
type: Class
comment: TBD
subclass of: BiospecimenType
is part of: schema.biothings.io
display name: Cells Biospecimen Type
required: sms:false

FixationDuration
type: Class
comment: The length of time, from beginning to end, required to process or preserve biospecimens in fixative (measured in minutes)
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Fixation Duration
required: sms:true

SlideChargeType
type: Class
comment: A description of the charge on the glass slide.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Uncharged
range includes: Charged
range includes: Coverslip
range includes: Notapplicable
range includes: Other
display name: Slide Charge Type
required: sms:true

SectionThicknessValue
type: Class
comment: Numeric value to describe the thickness of a slice to tissue taken from a biospecimen, measured in microns (um).
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Section Thickness Value
required: sms:true

SectioningDaysfromIndex
type: Class
comment: Number of days from the research participant's index date that the biospecimen was sectioned after collection. If not applicable please enter 'Not Applicable'
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Sectioning Days from Index
required: sms:true
validation rules: regex match \d+$|Not\sApplicable$|unknown$

ShippingConditionType
type: Class
comment: Text descriptor of the shipping environment of a biospecimen.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: AmbientPack
range includes: ColdPack
range includes: DryIce
range includes: IcePack
range includes: LiquidNitrogen
range includes: SpecimenatRoomTemperature
range includes: OtherShippingEnvironment
range includes: NotShipped
display name: Shipping Condition Type
required: sms:true

SpecimenLaterality
type: Class
comment: For tumors in paired organs, designates the side on which the specimen was obtained.
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Bilateral
range includes: Left
range includes: Right
range includes: Unknown
range includes: NotReported
range includes: NotApplicable
display name: Specimen Laterality
required: sms:true

PortionWeight
type: Class
comment: Numeric value that represents the sample portion weight, measured in milligrams.
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Portion Weight
required: sms:false

TotalVolume
type: Class
comment: Numeric value for the total amount of sample or specimen
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Total Volume
required: sms:false
requires dependency: TotalVolumeUnit

TumorTissueType
type: Class
comment: Text that describes the kind of disease present in the tumor specimen as related to a specific timepoint (add rows to select multiple values along with timepoints)
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: AdditionalPrimary
range includes: Localrecurrence
range includes: Metastatic
range includes: Premalignant
range includes: Primary
range includes: Recurrent
range includes: Normal
range includes: Normaladjacent
range includes: Normaldistant
range includes: Posttherapy
range includes: Posttherapyneoadjuvant
range includes: Posttherapyadjuvant
range includes: NotOtherwiseSpecified
range includes: Premalignant-insitu
range includes: Atypia-hyperplasia
range includes: Notanalyzed
display name: Tumor Tissue Type
required: sms:true

BiospecimenDimension1
type: Class
comment: First dimension of tissue fragment (number, up to one decimal place) measured in units as defined by the "dimensions_unit" CDE
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Biospecimen Dimension 1
required: sms:false
requires dependency: DimensionsUnit

BiospecimenDimension2
type: Class
comment: Second dimension of tissue fragment (number, up to one decimal place) measured in units as defined by the "dimensions_unit" CDE
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Biospecimen Dimension 2
required: sms:false

BiospecimenDimension3
type: Class
comment: Third dimension of tissue fragment (number, up to one decimal place) measured in units as defined by the "dimensions_unit" CDE
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Biospecimen Dimension 3
required: sms:false

SectionNumberinSequence
type: Class
comment: Numeric value (integer, including ranges) provided to a sample in a series of sections (list all adjacent sections in the Adjacent Biospecimen IDs field)
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Section Number in Sequence
required: sms:false

Aqueouswaterbased
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Aqueous water based
required: sms:false

Non-AqueousSolventbased
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Non-Aqueous Solvent based
required: sms:false

Xylene
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Xylene
required: sms:false

Toluene
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Toluene
required: sms:false

AntifadewithDAPI
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Antifade with DAPI
required: sms:false

AntifadewithoutDAPI
type: Class
comment: TBD
subclass of: MountingMedium
is part of: schema.biothings.io
display name: Antifade without DAPI
required: sms:false

PBS
type: Class
comment: TBD
subclass of: CollectionMedia
subclass of: MountingMedium
is part of: schema.biothings.io
display name: PBS
required: sms:false

CfDNAAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: cfDNA Analyte
required: sms:false

DNAAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: DNA Analyte
required: sms:false

RNAAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: RNA Analyte
required: sms:false

TotalRNAAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: Total RNA Analyte
required: sms:false

TissueBlockAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: Tissue Block Analyte
required: sms:false

TissueSectionAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: Tissue Section Analyte
required: sms:false

PBMCsorPlasmaorSerumAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: PBMCs or Plasma or Serum Analyte
required: sms:false

CDNALibrariesAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: cDNA Libraries Analyte
required: sms:false

PBMCs
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: PBMCs
required: sms:false

Plasma
type: Class
comment: TBD
subclass of: AnalyteType
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Plasma
required: sms:false

SerumAnalyte
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: Serum Analyte
required: sms:false

Lipid
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: lipid
required: sms:false

Metabolite
type: Class
comment: TBD
subclass of: AnalyteType
is part of: schema.biothings.io
display name: metabolite
required: sms:false

Autopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
subclass of: CauseofDeathSource
subclass of: MethodofDiagnosis
is part of: schema.biothings.io
display name: Autopsy
required: sms:false

Biopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
subclass of: MethodofDiagnosis
is part of: schema.biothings.io
display name: Biopsy
required: sms:false

FineNeedleAspirate
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Fine Needle Aspirate
required: sms:false

SurgicalResection
type: Class
comment: TBD
subclass of: AcquisitionMethodType
subclass of: MethodofDiagnosis
is part of: schema.biothings.io
display name: Surgical Resection
required: sms:false

PunchBiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Punch Biopsy
required: sms:false

ShaveBiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Shave Biopsy
required: sms:false

Excision
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Excision
required: sms:false

Re-excision
type: Class
comment: TBD
subclass of: BreastCarcinomaSurgicalProcedureName
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Re-excision
required: sms:false

SentinelNodeBiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Sentinel Node Biopsy
required: sms:false

Lymphadenectomy-RegionalNodes
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Lymphadenectomy - Regional Nodes
required: sms:false

OtherAcquisitionMethod
type: Class
comment: A custom acquisition method
subclass of: Biospecimen
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Other Acquisition Method
required: sms:false
requires dependency: AcquisitionMethodOtherSpecify

Noninducedsputum
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Non induced sputum
required: sms:false

Inducedsputum
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Induced sputum
required: sms:false

BAL(bronchialalveolarlavage)
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: BAL (bronchial alveolar lavage)
required: sms:false

Cytobrush
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Cytobrush
required: sms:false

Blooddraw
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Blood draw
required: sms:false

Fluidcollection
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Fluid collection
required: sms:false

Forcepsbiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Forceps biopsy
required: sms:false

Coreneedlebiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Core needle biopsy
required: sms:false

Endoscopicbiopsy
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Endoscopic biopsy
required: sms:false

Notspecified
type: Class
comment: TBD
subclass of: AcquisitionMethodType
is part of: schema.biothings.io
display name: Not specified
required: sms:false

AcquisitionMethodOtherSpecify
type: Class
comment: A custom acquisition method [Text - max length 100 characters]
subclass of: Biospecimen
is part of: schema.biothings.io
display name: Acquisition Method Other Specify
required: sms:true

Cryopreserved
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Cryopreserved
required: sms:false

Cryopreservationinliquidnitrogen-deadtissue
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Cryopreservation in liquid nitrogen - dead tissue
required: sms:false

Cryopreservationindryice-deadtissue
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Cryopreservation in dry ice - dead tissue
required: sms:false

Cryopreservationinliquidnitrogen-livecells
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Cryopreservation in liquid nitrogen - live cells
required: sms:false

Formalinfixedparaffinembedded-FFPE
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Formalin fixed paraffin embedded - FFPE
required: sms:false

Formalinfixed-unbuffered
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Formalin fixed-unbuffered
required: sms:false

Formalinfixed-buffered
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Formalin fixed-buffered
required: sms:false

Fresh
type: Class
comment: TBD
subclass of: StorageMethod
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Fresh
required: sms:false

http://schema.biothings.io/FreshdissociatedandsinglecellsortedintoplatesinNP40buffer
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Fresh dissociated and single cell sorted into plates in NP40 buffer
required: sms:false

OCT
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: OCT
required: sms:false

SnapFrozen
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Snap Frozen
required: sms:false

Frozen
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Frozen
required: sms:false

Negative80DegC
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Negative 80 Deg C
required: sms:false

LiquidNitrogen
type: Class
comment: TBD
subclass of: ShippingConditionType
subclass of: IschemicTemperature
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Liquid Nitrogen
required: sms:false

Freshdissociated
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Fresh dissociated
required: sms:false

Freshdissociatedandsinglecellsorted
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Fresh dissociated and single cell sorted
required: sms:false

Freshdissociatedandsinglecellsortedintoplates
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Fresh dissociated and single cell sorted into plates
required: sms:false

Methacarnfixedparaffinembedded-MFPE
type: Class
comment: TBD
subclass of: PreservationMethod
is part of: schema.biothings.io
display name: Methacarn fixed paraffin embedded - MFPE
required: sms:false

Acetone
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Acetone
required: sms:false

Alcohol
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Alcohol
required: sms:false

Formalin
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Formalin
required: sms:false

Glutaraldehyde
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Glutaraldehyde
required: sms:false

OCTmedia
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: OCT media
required: sms:false

RNAlater
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: RNAlater
required: sms:false

Saline
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Saline
required: sms:false

95%Ethanol
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: 95% Ethanol
required: sms:false

Dimidoester
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Dimidoester
required: sms:false

Carbodiimide
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Carbodiimide
required: sms:false

Dimethylacetamide
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Dimethylacetamide
required: sms:false

Para-benzoquinone
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Para-benzoquinone
required: sms:false

PAXgenetissue
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: PAXgene tissue
required: sms:false

TCLlysisbuffer
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: TCL lysis buffer
required: sms:false

NP40lysisbuffer
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: NP40 lysis buffer
required: sms:false

Methacarn
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Methacarn
required: sms:false

Cryo-store
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Cryo-store
required: sms:false

Carnoy'sFixative
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Carnoy's Fixative
required: sms:false

Polaxamer
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Polaxamer
required: sms:false

Unfixed
type: Class
comment: TBD
subclass of: FixativeType
is part of: schema.biothings.io
display name: Unfixed
required: sms:false

WarmIschemia
type: Class
comment: TBD
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: Warm Ischemia
required: sms:false

ColdIschemia
type: Class
comment: TBD
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: Cold Ischemia
required: sms:false

Ambientair
type: Class
comment: TBD
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: Ambient air
required: sms:false

4Cwetice
type: Class
comment: TBD
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: 4C wet ice
required: sms:false

Negative-20C
type: Class
comment: TBD
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: Negative -20C
required: sms:false

DryIce
type: Class
comment: TBD
subclass of: ShippingConditionType
subclass of: IschemicTemperature
is part of: schema.biothings.io
display name: Dry Ice
required: sms:false

DMEM
type: Class
comment: TBD
subclass of: CollectionMedia
is part of: schema.biothings.io
display name: DMEM
required: sms:false

DMEM+Serum
type: Class
comment: TBD
subclass of: CollectionMedia
is part of: schema.biothings.io
display name: DMEM+Serum
required: sms:false

RPMI
type: Class
comment: TBD
subclass of: CollectionMedia
is part of: schema.biothings.io
display name: RPMI
required: sms:false

RPMI+Serum
type: Class
comment: TBD
subclass of: CollectionMedia
is part of: schema.biothings.io
display name: RPMI+Serum
required: sms:false

PBS+Serum
type: Class
comment: TBD
subclass of: CollectionMedia
is part of: schema.biothings.io
display name: PBS+Serum
required: sms:false

Bilateral
type: Class
comment: TBD
subclass of: SpecimenLaterality
subclass of: Laterality
is part of: schema.biothings.io
display name: Bilateral
required: sms:false

Left
type: Class
comment: TBD
subclass of: SpecimenLaterality
subclass of: Laterality
subclass of: LungTumorLocationAnatomicSite
subclass of: SeminalVesicleInvasion
is part of: schema.biothings.io
display name: Left
required: sms:false

Right
type: Class
comment: TBD
subclass of: SpecimenLaterality
subclass of: LungTumorLocationAnatomicSite
subclass of: SeminalVesicleInvasion
subclass of: Laterality
is part of: schema.biothings.io
display name: Right
required: sms:false

TotalVolumeUnit
type: Class
comment: Unit of measurement used for the total amount of sample or specimen
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: ML
range includes: Cubicmillimeter
range includes: Squarecentimeter
display name: Total Volume Unit
required: sms:false

ML
type: Class
comment: TBD
subclass of: TotalVolumeUnit
is part of: schema.biothings.io
display name: mL
required: sms:false

Cubicmillimeter
type: Class
comment: TBD
subclass of: TotalVolumeUnit
is part of: schema.biothings.io
display name: cubic millimeter
required: sms:false

Squarecentimeter
type: Class
comment: TBD
subclass of: TotalVolumeUnit
is part of: schema.biothings.io
display name: square centimeter
required: sms:false

AdditionalPrimary
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Additional Primary
required: sms:false

Localrecurrence
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Local recurrence
required: sms:false

Metastatic
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Metastatic
required: sms:false

Premalignant
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Premalignant
required: sms:false

Recurrent
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Recurrent
required: sms:false

Normal
type: Class
comment: TBD
subclass of: ColorectalPolypType
subclass of: TumorTissueType
subclass of: TestResult
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Normal
required: sms:false

Normaladjacent
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Normal adjacent
required: sms:false

Normaldistant
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Normal distant
required: sms:false

Posttherapy
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Post therapy
required: sms:false

Posttherapyneoadjuvant
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Post therapy neoadjuvant
required: sms:false

Posttherapyadjuvant
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Post therapy adjuvant
required: sms:false

NotOtherwiseSpecified
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Not Otherwise Specified
required: sms:false

Premalignant-insitu
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Premalignant - in situ
required: sms:false

Atypia-hyperplasia
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Atypia - hyperplasia
required: sms:false

Notanalyzed
type: Class
comment: TBD
subclass of: TumorTissueType
is part of: schema.biothings.io
display name: Not analyzed
required: sms:false

Melanocytichyperplasia
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Melanocytic hyperplasia
required: sms:false

Atypicalmelanocyticproliferation
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Atypical melanocytic proliferation
required: sms:false

Melanomainsitu-superficialspreading
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Melanoma in situ - superficial spreading
required: sms:false

Melanomainsitu-lentigomalignatype
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Melanoma in situ - lentigo maligna type
required: sms:false

Melanomainsitu-acral-lentiginous
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Melanoma in situ - acral-lentiginous
required: sms:false

Melanomainsitu-arisinginagiantcongenitalnevus
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Melanoma in situ - arising in a giant congenital nevus
required: sms:false

Persistentmelanomainsitu
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Persistent melanoma in situ
required: sms:false

Melanomainsitu-nototherwiseclassified
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Melanoma in situ - not otherwise classified
required: sms:false

Scar-noresidualmelanoma
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Scar - no residual melanoma
required: sms:false

Invasivemelanoma-superficialspreading
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - superficial spreading
required: sms:false

Invasivemelanoma-nodulartype
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - nodular type
required: sms:false

Invasivemelanoma-lentigomaligna
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - lentigo maligna
required: sms:false

Invasivemelanoma-acrallentiginous
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - acral lentiginous
required: sms:false

Invasivemelanoma-desmoplastic
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - desmoplastic
required: sms:false

Invasivemelanoma-nevoid
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma - nevoid
required: sms:false

Invasivemelanoma-other
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Invasive melanoma - other
required: sms:false

NormalWDA
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Normal WDA
required: sms:false

Reservecellhyperplasia
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Reserve cell hyperplasia
required: sms:false

Squamousmetaplasia-mature
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Squamous metaplasia - mature
required: sms:false

Squamousmetaplasia-immature
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Squamous metaplasia - immature
required: sms:false

Milddysplasia
type: Class
comment: TBD
subclass of: DegreeofDysplasia
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Mild dysplasia
required: sms:false

Moderatedysplasia
type: Class
comment: TBD
subclass of: DegreeofDysplasia
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Moderate dysplasia
required: sms:false

Severedysplasia
type: Class
comment: TBD
subclass of: DegreeofDysplasia
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Severe dysplasia
required: sms:false

SquamousCarcinomainsitu
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
is part of: schema.biothings.io
display name: Squamous Carcinoma in situ
required: sms:false

Atypicaladenomatoushyperplasia
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Atypical adenomatous hyperplasia
required: sms:false

Adenocarcinomainsitu-nonmucinous
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Adenocarcinoma in situ - non mucinous
required: sms:false

Adenocarcinomainsitu-mucinous
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Adenocarcinoma in situ - mucinous
required: sms:false

BenigntumorNOS
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Benign tumor NOS
required: sms:false

Hamartoma
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Hamartoma
required: sms:false

CarcinomaNOS
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma NOS
required: sms:false

Nodiagnosispossible
type: Class
comment: TBD
subclass of: PreinvasiveMorphology
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: No diagnosis possible
required: sms:false

Uncharged
type: Class
comment: TBD
subclass of: SlideChargeType
is part of: schema.biothings.io
display name: Uncharged
required: sms:false

Charged
type: Class
comment: TBD
subclass of: SlideChargeType
is part of: schema.biothings.io
display name: Charged
required: sms:false

Coverslip
type: Class
comment: TBD
subclass of: SlideChargeType
is part of: schema.biothings.io
display name: Coverslip
required: sms:false

Notapplicable
type: Class
comment: TBD
subclass of: SlideChargeType
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: Not applicable
required: sms:false

Ambienttemperature
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Ambient temperature
required: sms:false

Cutslide
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Cut slide
required: sms:false

Frozenat-20C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen at -20C
required: sms:false

Frozenat-70C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen at -70C
required: sms:false

Frozenat-80C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen at -80C
required: sms:false

Frozenat-150C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen at -150C
required: sms:false

Frozeninliquidnitrogen
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen in liquid nitrogen
required: sms:false

Frozeninvaporphase
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Frozen in vapor phase
required: sms:false

Paraffinblock
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Paraffin block
required: sms:false

RNAlaterat4C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: RNAlater at 4C
required: sms:false

RNAlaterat25C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: RNAlater at 25C
required: sms:false

RNAlaterat-20C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: RNAlater at -20C
required: sms:false

Refrigeratedat4degrees
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Refrigerated at 4 degrees
required: sms:false

Refrigeratedvacuumchamber
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Refrigerated vacuum chamber
required: sms:false

4Cinvacuumchamber
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: 4C in vacuum chamber
required: sms:false

Desiccantat4C
type: Class
comment: TBD
subclass of: StorageMethod
is part of: schema.biothings.io
display name: Desiccant at 4C
required: sms:false

AmbientPack
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Ambient Pack
required: sms:false

ColdPack
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Cold Pack
required: sms:false

IcePack
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Ice Pack
required: sms:false

SpecimenatRoomTemperature
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Specimen at Room Temperature
required: sms:false

OtherShippingEnvironment
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Other Shipping Environment
required: sms:false

NotShipped
type: Class
comment: TBD
subclass of: ShippingConditionType
is part of: schema.biothings.io
display name: Not Shipped
required: sms:false

Pathologist
type: Class
comment: TBD
subclass of: HistologyAssessmentBy
is part of: schema.biothings.io
display name: Pathologist
required: sms:false

ResearchScientist
type: Class
comment: TBD
subclass of: HistologyAssessmentBy
is part of: schema.biothings.io
display name: Research Scientist
required: sms:false

Digital
type: Class
comment: TBD
subclass of: HistologyAssessmentMedium
is part of: schema.biothings.io
display name: Digital
required: sms:false

Microscopy
type: Class
comment: TBD
subclass of: HistologyAssessmentMedium
is part of: schema.biothings.io
display name: Microscopy
required: sms:false

Normalorbasalcellhyperplasiaormetaplasia
type: Class
comment: TBD
subclass of: DegreeofDysplasia
is part of: schema.biothings.io
display name: Normal or basal cell hyperplasia or metaplasia
required: sms:false

CarcinomainSitu
type: Class
comment: TBD
subclass of: DegreeofDysplasia
is part of: schema.biothings.io
display name: Carcinoma in Situ
required: sms:false

NuclearStain-DAPI
type: Class
comment: TBD
subclass of: FiducialMarker
is part of: schema.biothings.io
display name: Nuclear Stain - DAPI
required: sms:false

FluorescentBeads
type: Class
comment: TBD
subclass of: FiducialMarker
is part of: schema.biothings.io
display name: Fluorescent Beads
required: sms:false

GridSlides-Hemocytometer
type: Class
comment: TBD
subclass of: FiducialMarker
is part of: schema.biothings.io
display name: Grid Slides - Hemocytometer
required: sms:false

AdhesiveMarkers
type: Class
comment: TBD
subclass of: FiducialMarker
is part of: schema.biothings.io
display name: Adhesive Markers
required: sms:false

Vibratome
type: Class
comment: TBD
subclass of: SlicingMethod
is part of: schema.biothings.io
display name: Vibratome
required: sms:false

Cryosectioning
type: Class
comment: TBD
subclass of: SlicingMethod
is part of: schema.biothings.io
display name: Cryosectioning
required: sms:false

Tissuemolds
type: Class
comment: TBD
subclass of: SlicingMethod
is part of: schema.biothings.io
display name: Tissue molds
required: sms:false

Slidingmicrotome
type: Class
comment: TBD
subclass of: SlicingMethod
is part of: schema.biothings.io
display name: Sliding microtome
required: sms:false

Sectioning
type: Class
comment: TBD
subclass of: SlicingMethod
is part of: schema.biothings.io
display name: Sectioning
required: sms:false

DimensionsUnit
type: Class
comment: Unit of measurement used for dimension CDEs in metric system (i.e. cm, mm, etc)
subclass of: Biospecimen
is part of: schema.biothings.io
range includes: Mm
range includes: Cm
display name: Dimensions Unit
required: sms:false

Hispanicorlatino
type: Class
comment: TBD
subclass of: Ethnicity
is part of: schema.biothings.io
display name: hispanic or latino
required: sms:false

Nothispanicorlatino
type: Class
comment: TBD
subclass of: Ethnicity
is part of: schema.biothings.io
display name: not hispanic or latino
required: sms:false

Notallowedtocollect
type: Class
comment: TBD
subclass of: Ethnicity
subclass of: Race
is part of: schema.biothings.io
display name: not allowed to collect
required: sms:false

Female
type: Class
comment: TBD
subclass of: Gender
subclass of: RelationshipGender
is part of: schema.biothings.io
display name: Female
required: sms:false

Male
type: Class
comment: TBD
subclass of: Gender
subclass of: RelationshipGender
is part of: schema.biothings.io
display name: Male
required: sms:false

White
type: Class
comment: TBD
subclass of: Race
is part of: schema.biothings.io
display name: white
required: sms:false

Americanindianoralaskanative
type: Class
comment: TBD
subclass of: Race
is part of: schema.biothings.io
display name: american indian or alaska native
required: sms:false

Blackorafricanamerican
type: Class
comment: TBD
subclass of: Race
is part of: schema.biothings.io
display name: black or african american
required: sms:false

Asian
type: Class
comment: TBD
subclass of: Race
is part of: schema.biothings.io
display name: asian
required: sms:false

Nativehawaiianorotherpacificislander
type: Class
comment: TBD
subclass of: Race
is part of: schema.biothings.io
display name: native hawaiian or other pacific islander
required: sms:false

Alive
type: Class
comment: This indicates the participant is alive and defines further required metadata
subclass of: Patient
subclass of: VitalStatus
is part of: schema.biothings.io
display name: Alive
required: sms:false
requires dependency: DaystoVitalStatusReference

Dead
type: Class
comment: This indicates the participant is dead and defines further required metadata
subclass of: Demographics
subclass of: VitalStatus
is part of: schema.biothings.io
display name: Dead
required: sms:false
requires dependency: YearofDeath
requires dependency: CauseofDeath
requires dependency: CauseofDeathSource
requires dependency: DaystoDeath

YearofDeath
type: Class
comment: Numeric value to represent the year of the death of an individual.
subclass of: Demographics
is part of: schema.biothings.io
display name: Year of Death
required: sms:true

CauseofDeath
type: Class
comment: The cause of death
subclass of: Demographics
is part of: schema.biothings.io
range includes: CancerRelated
range includes: CardiovascularDisorderNOS
range includes: End-stageRenalDisease
range includes: Infection
range includes: NotCancerRelated
range includes: RenalDisorderNOS
range includes: SpinalMuscularAtrophy
range includes: SurgicalComplications
range includes: Toxicity
range includes: NotReported
range includes: Unknown
range includes: NotApplicable
display name: Cause of Death
required: sms:true

CauseofDeathSource
type: Class
comment: The text term used to describe the source used to determine the patient's cause of death.
subclass of: Demographics
is part of: schema.biothings.io
range includes: Autopsy
range includes: DeathCertificate
range includes: MedicalRecord
range includes: SocialSecurityDeathIndex
range includes: Obituary
range includes: Unknown
range includes: NotReported
display name: Cause of Death Source
required: sms:false

DaystoDeath
type: Class
comment: Number of days between the date used for index and the date from a person's date of death represented as a calculated number of days. If not applicable please enter 'Not Applicable'
subclass of: Demographics
is part of: schema.biothings.io
display name: Days to Death
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

Afghanistan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Afghanistan
required: sms:false

Albania
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Albania
required: sms:false

Algeria
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Algeria
required: sms:false

Andorra
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Andorra
required: sms:false

Angola
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Angola
required: sms:false

Anguilla
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Anguilla
required: sms:false

AntiguaandBarbuda
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Antigua and Barbuda
required: sms:false

Argentina
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Argentina
required: sms:false

Armenia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Armenia
required: sms:false

Aruba
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Aruba
required: sms:false

Australia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Australia
required: sms:false

Austria
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Austria
required: sms:false

Azerbaijan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Azerbaijan
required: sms:false

Bahamas
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bahamas
required: sms:false

Bahrain
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bahrain
required: sms:false

Bangladesh
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bangladesh
required: sms:false

Barbados
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Barbados
required: sms:false

Belarus
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Belarus
required: sms:false

Belgium
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Belgium
required: sms:false

Belize
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Belize
required: sms:false

Benin
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Benin
required: sms:false

Bermuda
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bermuda
required: sms:false

Bhutan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bhutan
required: sms:false

Bolivia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bolivia
required: sms:false

BosniaandHerzegovina
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bosnia and Herzegovina
required: sms:false

Botswana
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Botswana
required: sms:false

Brazil
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Brazil
required: sms:false

Brunei
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Brunei
required: sms:false

Bulgaria
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Bulgaria
required: sms:false

BurkinaFaso
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Burkina Faso
required: sms:false

Burundi
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Burundi
required: sms:false

Cambodia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cambodia
required: sms:false

Cameroon
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cameroon
required: sms:false

Canada
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Canada
required: sms:false

CapeVerde
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cape Verde
required: sms:false

CaymanIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cayman Islands
required: sms:false

CentralAfricanRepublic
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Central African Republic
required: sms:false

Chad
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Chad
required: sms:false

Chile
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Chile
required: sms:false

China
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: China
required: sms:false

Colombia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Colombia
required: sms:false

Comoros
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Comoros
required: sms:false

Congo
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Congo
required: sms:false

CookIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cook Islands
required: sms:false

CostaRica
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Costa Rica
required: sms:false

Coted'Ivoire
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cote d'Ivoire
required: sms:false

Croatia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Croatia
required: sms:false

Cuba
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cuba
required: sms:false

Curacao
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Curacao
required: sms:false

Cyprus
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Cyprus
required: sms:false

CzechRepublic(Czechia)
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Czech Republic (Czechia)
required: sms:false

DemocraticRepublicoftheCongo
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Democratic Republic of the Congo
required: sms:false

Denmark
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Denmark
required: sms:false

Djibouti
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Djibouti
required: sms:false

Dominica
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Dominica
required: sms:false

DominicanRepublic
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Dominican Republic
required: sms:false

Ecuador
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Ecuador
required: sms:false

Egypt
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Egypt
required: sms:false

ElSalvador
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: El Salvador
required: sms:false

EquatorialGuinea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Equatorial Guinea
required: sms:false

Eritrea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Eritrea
required: sms:false

Estonia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Estonia
required: sms:false

Eswatini
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Eswatini
required: sms:false

Ethiopia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Ethiopia
required: sms:false

FalklandIslands(Malvinas)
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Falkland Islands (Malvinas)
required: sms:false

FaroeIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Faroe Islands
required: sms:false

FederatedStatesofMicronesia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Federated States of Micronesia
required: sms:false

Fiji
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Fiji
required: sms:false

Finland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Finland
required: sms:false

France
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: France
required: sms:false

FrenchGuiana
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: French Guiana
required: sms:false

FrenchPolynesia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: French Polynesia
required: sms:false

Gabon
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Gabon
required: sms:false

Gambia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Gambia
required: sms:false

Georgia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Georgia
required: sms:false

Germany
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Germany
required: sms:false

Ghana
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Ghana
required: sms:false

Gibraltar
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Gibraltar
required: sms:false

Greece
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Greece
required: sms:false

Greenland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Greenland
required: sms:false

Grenada
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Grenada
required: sms:false

Guadeloupe
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guadeloupe
required: sms:false

Guam
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guam
required: sms:false

Guatemala
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guatemala
required: sms:false

Guernsey
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guernsey
required: sms:false

Guinea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guinea
required: sms:false

Guinea-Bissau
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guinea-Bissau
required: sms:false

Guyana
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Guyana
required: sms:false

Haiti
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Haiti
required: sms:false

HolySee
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Holy See
required: sms:false

Honduras
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Honduras
required: sms:false

HongKong
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Hong Kong
required: sms:false

Hungary
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Hungary
required: sms:false

Iceland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Iceland
required: sms:false

India
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: India
required: sms:false

Indonesia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Indonesia
required: sms:false

Iran
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Iran
required: sms:false

Iraq
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Iraq
required: sms:false

Ireland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Ireland
required: sms:false

IsleofMan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Isle of Man
required: sms:false

Israel
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Israel
required: sms:false

Italy
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Italy
required: sms:false

Jamaica
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Jamaica
required: sms:false

Japan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Japan
required: sms:false

Jersey
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Jersey
required: sms:false

Jordan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Jordan
required: sms:false

Kazakhstan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kazakhstan
required: sms:false

Kenya
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kenya
required: sms:false

Kiribati
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kiribati
required: sms:false

Kosovo
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kosovo
required: sms:false

Kuwait
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kuwait
required: sms:false

Kyrgyzstan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Kyrgyzstan
required: sms:false

Laos
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Laos
required: sms:false

Latvia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Latvia
required: sms:false

Lebanon
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Lebanon
required: sms:false

Lesotho
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Lesotho
required: sms:false

Liberia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Liberia
required: sms:false

Libya
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Libya
required: sms:false

Liechtenstein
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Liechtenstein
required: sms:false

Lithuania
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Lithuania
required: sms:false

Luxembourg
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Luxembourg
required: sms:false

Macau
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Macau
required: sms:false

Madagascar
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Madagascar
required: sms:false

Malawi
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Malawi
required: sms:false

Malaysia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Malaysia
required: sms:false

Maldives
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Maldives
required: sms:false

Mali
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mali
required: sms:false

Malta
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Malta
required: sms:false

MarshallIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Marshall Islands
required: sms:false

Martinique
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Martinique
required: sms:false

Mauritania
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mauritania
required: sms:false

Mauritius
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mauritius
required: sms:false

Mayotte
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mayotte
required: sms:false

Mexico
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mexico
required: sms:false

Moldova
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Moldova
required: sms:false

Monaco
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Monaco
required: sms:false

Mongolia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mongolia
required: sms:false

Montenegro
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Montenegro
required: sms:false

Montserrat
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Montserrat
required: sms:false

Morocco
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Morocco
required: sms:false

Mozambique
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Mozambique
required: sms:false

Myanmar
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Myanmar
required: sms:false

Namibia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Namibia
required: sms:false

Nauru
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Nauru
required: sms:false

Nepal
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Nepal
required: sms:false

Netherlands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Netherlands
required: sms:false

NewCaledonia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: New Caledonia
required: sms:false

NewZealand
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: New Zealand
required: sms:false

Nicaragua
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Nicaragua
required: sms:false

Niger
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Niger
required: sms:false

Nigeria
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Nigeria
required: sms:false

Niue
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Niue
required: sms:false

NorthKorea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: North Korea
required: sms:false

NorthMacedonia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: North Macedonia
required: sms:false

NorthernMarianaIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Northern Mariana Islands
required: sms:false

Norway
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Norway
required: sms:false

Oman
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Oman
required: sms:false

Pakistan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Pakistan
required: sms:false

Palau
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Palau
required: sms:false

Panama
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Panama
required: sms:false

PapuaNewGuinea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Papua New Guinea
required: sms:false

Paraguay
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Paraguay
required: sms:false

Peru
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Peru
required: sms:false

Philippines
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Philippines
required: sms:false

Poland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Poland
required: sms:false

Portugal
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Portugal
required: sms:false

PuertoRico
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Puerto Rico
required: sms:false

Qatar
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Qatar
required: sms:false

Reunion
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Reunion
required: sms:false

Romania
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Romania
required: sms:false

Russia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Russia
required: sms:false

Rwanda
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Rwanda
required: sms:false

SaintHelenaAscensionandTristandaCunha
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saint Helena Ascension and Tristan da Cunha
required: sms:false

SaintKittsandNevis
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saint Kitts and Nevis
required: sms:false

SaintLucia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saint Lucia
required: sms:false

SaintPierreandMiquelon
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saint Pierre and Miquelon
required: sms:false

SaintVincentandtheGrenadines
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saint Vincent and the Grenadines
required: sms:false

Samoa
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Samoa
required: sms:false

SanMarino
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: San Marino
required: sms:false

SaoTomeandPrincipe
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Sao Tome and Principe
required: sms:false

SaudiArabia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Saudi Arabia
required: sms:false

Senegal
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Senegal
required: sms:false

Serbia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Serbia
required: sms:false

Seychelles
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Seychelles
required: sms:false

SierraLeone
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Sierra Leone
required: sms:false

Singapore
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Singapore
required: sms:false

Slovakia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Slovakia
required: sms:false

Slovenia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Slovenia
required: sms:false

SolomonIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Solomon Islands
required: sms:false

Somalia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Somalia
required: sms:false

SouthAfrica
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: South Africa
required: sms:false

SouthKorea
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: South Korea
required: sms:false

SouthSudan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: South Sudan
required: sms:false

Spain
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Spain
required: sms:false

SriLanka
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Sri Lanka
required: sms:false

StateofPalestine
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: State of Palestine
required: sms:false

Sudan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Sudan
required: sms:false

Suriname
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Suriname
required: sms:false

Svalbard&JanMayenIslands
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Svalbard & Jan Mayen Islands
required: sms:false

Sweden
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Sweden
required: sms:false

Switzerland
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Switzerland
required: sms:false

Syria
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Syria
required: sms:false

Taiwan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Taiwan
required: sms:false

Tajikistan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tajikistan
required: sms:false

Tanzania
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tanzania
required: sms:false

Thailand
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Thailand
required: sms:false

Timor-Leste
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Timor-Leste
required: sms:false

Togo
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Togo
required: sms:false

Tokelau
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tokelau
required: sms:false

Tonga
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tonga
required: sms:false

TrinidadandTobago
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Trinidad and Tobago
required: sms:false

Tunisia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tunisia
required: sms:false

Turkey
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Turkey
required: sms:false

Turkmenistan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Turkmenistan
required: sms:false

Tuvalu
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Tuvalu
required: sms:false

Uganda
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Uganda
required: sms:false

Ukraine
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Ukraine
required: sms:false

UnitedArabEmirates
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: United Arab Emirates
required: sms:false

UnitedKingdom
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: United Kingdom
required: sms:false

UnitedStates
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: United States
required: sms:false

Uruguay
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Uruguay
required: sms:false

Uzbekistan
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Uzbekistan
required: sms:false

Vanuatu
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Vanuatu
required: sms:false

Venezuela
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Venezuela
required: sms:false

Vietnam
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Vietnam
required: sms:false

VirginIslandsBritish
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Virgin Islands British
required: sms:false

VirginIslandsU.S.
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Virgin Islands U.S.
required: sms:false

WallisandFutuna
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Wallis and Futuna
required: sms:false

WesternSahara
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Western Sahara
required: sms:false

Yemen
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Yemen
required: sms:false

Zambia
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Zambia
required: sms:false

Zimbabwe
type: Class
comment: TBD
subclass of: CountryofResidence
subclass of: CountryofBirth
is part of: schema.biothings.io
display name: Zimbabwe
required: sms:false

CancerRelated
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Cancer Related
required: sms:false

CardiovascularDisorderNOS
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Cardiovascular Disorder NOS
required: sms:false

End-stageRenalDisease
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: End-stage Renal Disease
required: sms:false

Infection
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Infection
required: sms:false

NotCancerRelated
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Not Cancer Related
required: sms:false

RenalDisorderNOS
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Renal Disorder NOS
required: sms:false

SpinalMuscularAtrophy
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Spinal Muscular Atrophy
required: sms:false

SurgicalComplications
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Surgical Complications
required: sms:false

Toxicity
type: Class
comment: TBD
subclass of: CauseofDeath
is part of: schema.biothings.io
display name: Toxicity
required: sms:false

DeathCertificate
type: Class
comment: TBD
subclass of: CauseofDeathSource
is part of: schema.biothings.io
display name: Death Certificate
required: sms:false

MedicalRecord
type: Class
comment: TBD
subclass of: CauseofDeathSource
is part of: schema.biothings.io
display name: Medical Record
required: sms:false

SocialSecurityDeathIndex
type: Class
comment: TBD
subclass of: CauseofDeathSource
is part of: schema.biothings.io
display name: Social Security Death Index
required: sms:false

Obituary
type: Class
comment: TBD
subclass of: CauseofDeathSource
is part of: schema.biothings.io
display name: Obituary
required: sms:false

Bachelor'sdegree
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Bachelor's degree
required: sms:false

Doctoraldegreeorprofessionaldegree
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Doctoral degree or professional degree
required: sms:false

Gradeschool
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Grade school
required: sms:false

Graduateorprofessionaldegree
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Graduate or professional degree
required: sms:false

http://schema.biothings.io/Highschoolgraduate(includingequivalency)
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: High school graduate (including equivalency)
required: sms:false

Master'sdegree
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Master's degree
required: sms:false

Noformaleducation
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: No formal education
required: sms:false

Nothighschoolgraduate
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Not high school graduate
required: sms:false

Somecollegeorassociatedegree
type: Class
comment: TBD
subclass of: EducationLevel
is part of: schema.biothings.io
display name: Some college or associate degree
required: sms:false

Datanotavailable
type: Class
comment: TBD
subclass of: BreastCarcinomaDetectionMethodType
subclass of: InvasiveLobularBreastCarcinomaHistologicCategory
subclass of: BreastCancerGenomicTestPerformed
subclass of: MammaprintRiskGroup
subclass of: OncotypeRiskGroup
subclass of: MultifocalBreastCarcinomaPresentIndicator
subclass of: MulticentricBreastCarcinomaPresentIndicator
subclass of: OvarianCancerPlatinumStatus
subclass of: ModeofCancerDetection
subclass of: LungCancerDetectionMethodType
subclass of: PriorInvasiveBreastDisease
subclass of: BIRADSMammographyBreastDensityCategory
subclass of: OvarianCancerSurgicalOutcome
subclass of: ColorectalCancerDetectionMethodType
subclass of: BreastQuadrantSite
subclass of: BreastCancerAssessmentTests
subclass of: BreastImagingPerformedType
subclass of: EducationLevel
subclass of: OvarianCancerHistologicSubtype
subclass of: InvasiveDuctalBreastCarcinomaHistologicCategory
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Data not available
required: sms:false

ClinicalTier2
type: Class
comment: TBD
subclass of: Thing
is part of: schema.biothings.io
display name: Clinical Tier 2
required: sms:false

MedicallyUnderservedArea-Yes
type: Class
comment: Patient's zip code is in a medically underserved area
subclass of: ClinicalTier2
subclass of: MedicallyUnderservedArea
is part of: schema.biothings.io
display name: Medically Underserved Area - Yes
required: sms:false
requires dependency: MedicallyUnderservedScore

MedicallyUnderservedArea-No
type: Class
comment: Patient's zip code is not in a medically underserved area
subclass of: ClinicalTier2
subclass of: MedicallyUnderservedArea
is part of: schema.biothings.io
display name: Medically Underserved Area - No
required: sms:false

MedicallyUnderservedArea-Unknown
type: Class
comment: Insufficient data to look up the Medically Underserved Area value
subclass of: ClinicalTier2
subclass of: MedicallyUnderservedArea
is part of: schema.biothings.io
display name: Medically Underserved Area - Unknown
required: sms:false

MedicallyUnderservedScore
type: Class
comment: Index of Medical Underservice (IMU) score, a number between 0 and 100, where 0 represents completely underserved and 100 represents best served or least underserved. Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the asociated county on the right side of the result field. Go to data.hrsa.gov website and select Query Data. Pick the Medically Underserved Areas/Populations (MUA/P) data source in the step 1 menu and select View Data. Enter the name of the county (______ county) in the first "Service Area" column, adding the state in the 5th column may help direct you to the data. Enter the Index of Medical Underservice Score in the fourth column to one decimal place as the value.
subclass of: ClinicalTier2
is part of: schema.biothings.io
display name: Medically Underserved Score
required: sms:false

UrbanPopulation(population>50000)
type: Class
comment: TBD
subclass of: RuralvsUrban
is part of: schema.biothings.io
display name: Urban Population (population >50000)
required: sms:false

UrbanCluster(population2500-50000)
type: Class
comment: TBD
subclass of: RuralvsUrban
is part of: schema.biothings.io
display name: Urban Cluster (population 2500 - 50000)
required: sms:false

RuralPopulation(population<2500)
type: Class
comment: TBD
subclass of: RuralvsUrban
is part of: schema.biothings.io
display name: Rural Population (population <2500)
required: sms:false

RelationshipGender
type: Class
comment: The text term used to describe the gender of the patient's relative with a history of cancer.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: Female
range includes: Male
range includes: Unknown
range includes: Unspecified
range includes: NotReported
display name: Relationship Gender
required: sms:false

RelationshipAgeatDiagnosis
type: Class
comment: The age (in years) when the patient's relative was first diagnosed.
subclass of: FamilyHistory
is part of: schema.biothings.io
display name: Relationship Age at Diagnosis
required: sms:false

RelationshipPrimaryDiagnosis
type: Class
comment: The text term used to describe the malignant diagnosis of the patient's relative with a history of cancer.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: AdrenalGlandCancer
range includes: BasalCellCancer
range includes: BileDuctCancer
range includes: BladderCancer
range includes: BloodCancer
range includes: BoneCancer
range includes: BrainCancer
range includes: BreastCancer
range includes: Cancer
range includes: CervicalCancer
range includes: Chondrosarcoma
range includes: CNSCancer
range includes: ColorectalCancer
range includes: EsophagealCancer
range includes: EwingSarcoma
range includes: GallbladderCancer
range includes: GastricCancer
range includes: Glioblastoma
range includes: GynecologicCancer
range includes: HeadandNeckCancer
range includes: HematologicCancer
range includes: KaposiSarcoma
range includes: KidneyCancer
range includes: LaryngealCancer
range includes: Leukemia
range includes: LiverCancer
range includes: LungCancer
range includes: LymphNodeCancer
range includes: Lymphoma
range includes: Melanoma
range includes: Mesothelioma
range includes: MultipleMyeloma
range includes: Neuroblastoma
range includes: Osteosarcoma
range includes: OvarianCancer
range includes: PancreasCancer
range includes: ProstateCancer
range includes: RectalCancer
range includes: Rhabdomyosarcoma
range includes: Sarcoma
range includes: SkinCancer
range includes: SpleenCancer
range includes: TesticularCancer
range includes: ThroatCancer
range includes: ThyroidCancer
range includes: TongueCancer
range includes: TonsillarCancer
range includes: UterineCancer
range includes: WilmsTumor
range includes: Unknown
range includes: NotReported
display name: Relationship Primary Diagnosis
required: sms:false

AdrenalGlandCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Adrenal Gland Cancer
required: sms:false

BasalCellCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal Cell Cancer
required: sms:false

BileDuctCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile Duct Cancer
required: sms:false

BladderCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Bladder Cancer
required: sms:false

BloodCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Blood Cancer
required: sms:false

BoneCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Bone Cancer
required: sms:false

BrainCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Brain Cancer
required: sms:false

BreastCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Breast Cancer
required: sms:false

Cancer
type: Class
comment: TBD
subclass of: BreastBiopsyProcedureFindingType
subclass of: ColorectalPolypType
subclass of: RelationshipPrimaryDiagnosis
subclass of: Comorbidity
subclass of: RiskFactor
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cancer
required: sms:false

CervicalCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Cervical Cancer
required: sms:false

Chondrosarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Chondrosarcoma
required: sms:false

CNSCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: CNS Cancer
required: sms:false

ColorectalCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Colorectal Cancer
required: sms:false

EsophagealCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal Cancer
required: sms:false

EwingSarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Ewing Sarcoma
required: sms:false

GallbladderCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Gallbladder Cancer
required: sms:false

GastricCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastric Cancer
required: sms:false

Glioblastoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Glioblastoma
required: sms:false

GynecologicCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Gynecologic Cancer
required: sms:false

HeadandNeckCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Head and Neck Cancer
required: sms:false

HematologicCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Hematologic Cancer
required: sms:false

KaposiSarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Kaposi Sarcoma
required: sms:false

KidneyCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Kidney Cancer
required: sms:false

LaryngealCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Laryngeal Cancer
required: sms:false

Leukemia
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Leukemia
required: sms:false

LiverCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Liver Cancer
required: sms:false

LungCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Lung Cancer
required: sms:false

LymphNodeCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Lymph Node Cancer
required: sms:false

Lymphoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Lymphoma
required: sms:false

Melanoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Melanoma
required: sms:false

Mesothelioma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Mesothelioma
required: sms:false

MultipleMyeloma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Multiple Myeloma
required: sms:false

Neuroblastoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Neuroblastoma
required: sms:false

Osteosarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Osteosarcoma
required: sms:false

OvarianCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Ovarian Cancer
required: sms:false

PancreasCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Pancreas Cancer
required: sms:false

ProstateCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Prostate Cancer
required: sms:false

RectalCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Rectal Cancer
required: sms:false

Rhabdomyosarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Rhabdomyosarcoma
required: sms:false

Sarcoma
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Sarcoma
required: sms:false

SkinCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Skin Cancer
required: sms:false

SpleenCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Spleen Cancer
required: sms:false

TesticularCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Testicular Cancer
required: sms:false

ThroatCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Throat Cancer
required: sms:false

ThyroidCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Thyroid Cancer
required: sms:false

TongueCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Tongue Cancer
required: sms:false

TonsillarCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Tonsillar Cancer
required: sms:false

UterineCancer
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Uterine Cancer
required: sms:false

WilmsTumor
type: Class
comment: TBD
subclass of: RelationshipPrimaryDiagnosis
is part of: schema.biothings.io
display name: Wilms Tumor
required: sms:false

RelationshipType
type: Class
comment: The subgroup that describes the state of connectedness between members of the unit of society organized around kinship ties.
subclass of: FamilyHistory
is part of: schema.biothings.io
range includes: AdoptedDaughter
range includes: AdoptedSon
range includes: AdoptiveBrother
range includes: AdoptiveFather
range includes: AdoptiveMother
range includes: AdoptiveSister
range includes: Aunt
range includes: Brother
range includes: Brother-in-law
range includes: Child
range includes: Cousin
range includes: Daughter
range includes: Daughter-in-law
range includes: DomesticPartner
range includes: Father
range includes: Father-in-law
range includes: FemaleCousin
range includes: FirstCousin
range includes: FirstCousinOnceRemoved
range includes: FosterBrother
range includes: FosterDaughter
range includes: FosterFather
range includes: FosterMother
range includes: FosterSister
range includes: FosterSon
range includes: FraternalTwinBrother
range includes: FraternalTwinSibling
range includes: FraternalTwinSister
range includes: FullBrother
range includes: FullSister
range includes: GrandNephew
range includes: GrandNiece
range includes: Grandchild
range includes: Granddaughter
range includes: Grandfather
range includes: Grandmother
range includes: Grandparent
range includes: Grandson
range includes: GreatGrandchild
range includes: HalfBrother
range includes: HalfSibling
range includes: HalfSister
range includes: Husband
range includes: IdenticalTwinBrother
range includes: IdenticalTwinSibling
range includes: IdenticalTwinSister
range includes: LegalGuardian
range includes: MaleCousin
range includes: MaternalAunt
range includes: MaternalFirstCousin
range includes: MaternalFirstCousinOnceRemoved
range includes: MaternalGrandfather
range includes: MaternalGrandmother
range includes: MaternalGrandparent
range includes: MaternalGreatAunt
range includes: MaternalGreatGrandparent
range includes: MaternalGreatUncle
range includes: MaternalHalfBrother
range includes: MaternalHalfSibling
range includes: MaternalHalfSister
range includes: MaternalUncle
range includes: Mother
range includes: Mother-in-law
range includes: NaturalBrother
range includes: NaturalChild
range includes: NaturalDaughter
range includes: NaturalFather
range includes: NaturalGrandchild
range includes: NaturalGrandfather
range includes: NaturalGrandmother
range includes: NaturalGrandparent
range includes: NaturalMother
range includes: NaturalParent
range includes: NaturalSibling
range includes: NaturalSister

AdoptedDaughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adopted Daughter
required: sms:false

AdoptedSon
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adopted Son
required: sms:false

AdoptiveBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adoptive Brother
required: sms:false

AdoptiveFather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adoptive Father
required: sms:false

AdoptiveMother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adoptive Mother
required: sms:false

AdoptiveSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Adoptive Sister
required: sms:false

Aunt
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Aunt
required: sms:false

Brother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Brother
required: sms:false

Brother-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Brother-in-law
required: sms:false

Child
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Child
required: sms:false

Cousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Cousin
required: sms:false

Daughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Daughter
required: sms:false

Daughter-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Daughter-in-law
required: sms:false

DomesticPartner
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Domestic Partner
required: sms:false

Father
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Father
required: sms:false

Father-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Father-in-law
required: sms:false

FemaleCousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Female Cousin
required: sms:false

FirstCousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: First Cousin
required: sms:false

FirstCousinOnceRemoved
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: First Cousin Once Removed
required: sms:false

FosterBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Brother
required: sms:false

FosterDaughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Daughter
required: sms:false

FosterFather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Father
required: sms:false

FosterMother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Mother
required: sms:false

FosterSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Sister
required: sms:false

FosterSon
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Foster Son
required: sms:false

FraternalTwinBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Fraternal Twin Brother
required: sms:false

FraternalTwinSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Fraternal Twin Sibling
required: sms:false

FraternalTwinSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Fraternal Twin Sister
required: sms:false

FullBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Full Brother
required: sms:false

FullSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Full Sister
required: sms:false

GrandNephew
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grand Nephew
required: sms:false

GrandNiece
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grand Niece
required: sms:false

Grandchild
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grandchild
required: sms:false

Granddaughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Granddaughter
required: sms:false

Grandfather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grandfather
required: sms:false

Grandmother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grandmother
required: sms:false

Grandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grandparent
required: sms:false

Grandson
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Grandson
required: sms:false

GreatGrandchild
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Great Grandchild
required: sms:false

HalfBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Half Brother
required: sms:false

HalfSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Half Sibling
required: sms:false

HalfSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Half Sister
required: sms:false

Husband
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Husband
required: sms:false

IdenticalTwinBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Identical Twin Brother
required: sms:false

IdenticalTwinSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Identical Twin Sibling
required: sms:false

IdenticalTwinSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Identical Twin Sister
required: sms:false

LegalGuardian
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Legal Guardian
required: sms:false

MaleCousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Male Cousin
required: sms:false

MaternalAunt
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Aunt
required: sms:false

MaternalFirstCousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal First Cousin
required: sms:false

MaternalFirstCousinOnceRemoved
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal First Cousin Once Removed
required: sms:false

MaternalGrandfather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Grandfather
required: sms:false

MaternalGrandmother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Grandmother
required: sms:false

MaternalGrandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Grandparent
required: sms:false

MaternalGreatAunt
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Great Aunt
required: sms:false

MaternalGreatGrandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Great Grandparent
required: sms:false

MaternalGreatUncle
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Great Uncle
required: sms:false

MaternalHalfBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Half Brother
required: sms:false

MaternalHalfSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Half Sibling
required: sms:false

MaternalHalfSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Half Sister
required: sms:false

MaternalUncle
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Maternal Uncle
required: sms:false

Mother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Mother
required: sms:false

Mother-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Mother-in-law
required: sms:false

NaturalBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Brother
required: sms:false

NaturalChild
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Child
required: sms:false

NaturalDaughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Daughter
required: sms:false

NaturalFather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Father
required: sms:false

NaturalGrandchild
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Grandchild
required: sms:false

NaturalGrandfather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Grandfather
required: sms:false

NaturalGrandmother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Grandmother
required: sms:false

NaturalGrandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Grandparent
required: sms:false

NaturalMother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Mother
required: sms:false

NaturalParent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Parent
required: sms:false

NaturalSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Sibling
required: sms:false

NaturalSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Sister
required: sms:false

NaturalSon
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Natural Son
required: sms:false

Nephew
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Nephew
required: sms:false

Niece
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Niece
required: sms:false

NieceSecondDegreeRelative
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Niece Second Degree Relative
required: sms:false

Parent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Parent
required: sms:false

PaternalAunt
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Aunt
required: sms:false

PaternalFirstCousin
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal First Cousin
required: sms:false

PaternalFirstCousinOnceRemoved
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal First Cousin Once Removed
required: sms:false

PaternalGrandfather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Grandfather
required: sms:false

PaternalGrandmother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Grandmother
required: sms:false

PaternalGrandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Grandparent
required: sms:false

PaternalGreatAunt
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Great Aunt
required: sms:false

PaternalGreatGrandparent
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Great Grandparent
required: sms:false

PaternalGreatUncle
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Great Uncle
required: sms:false

PaternalHalfBrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Half Brother
required: sms:false

PaternalHalfSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Half Sibling
required: sms:false

PaternalHalfSister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Half Sister
required: sms:false

PaternalUncle
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Paternal Uncle
required: sms:false

Refused
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Refused
required: sms:false

Sibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Sibling
required: sms:false

Sister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Sister
required: sms:false

Sister-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Sister-in-law
required: sms:false

Son
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Son
required: sms:false

Son-in-law
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Son-in-law
required: sms:false

Spouse
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Spouse
required: sms:false

StepChild
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Step Child
required: sms:false

StepSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Step Sibling
required: sms:false

Stepbrother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepbrother
required: sms:false

Stepdaughter
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepdaughter
required: sms:false

Stepfather
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepfather
required: sms:false

Stepmother
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepmother
required: sms:false

Stepsister
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepsister
required: sms:false

Stepson
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Stepson
required: sms:false

TwinSibling
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Twin Sibling
required: sms:false

Uncle
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Uncle
required: sms:false

Unrelated
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Unrelated
required: sms:false

Ward
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Ward
required: sms:false

Wife
type: Class
comment: TBD
subclass of: RelationshipType
is part of: schema.biothings.io
display name: Wife
required: sms:false

Yes-CancerHistoryRelative
type: Class
comment: Individual has a relative with cancer history
subclass of: FamilyHistory
subclass of: RelativewithCancerHistory
is part of: schema.biothings.io
display name: Yes - Cancer History Relative
required: sms:false
requires dependency: RelativeswithCancerHistoryCount
requires dependency: RelationshipType
requires dependency: RelationshipPrimaryDiagnosis
requires dependency: RelationshipGender
requires dependency: RelationshipAgeatDiagnosis

RelativeswithCancerHistoryCount
type: Class
comment: The number of relatives the patient has with a known history of cancer.
subclass of: FamilyHistory
is part of: schema.biothings.io
display name: Relatives with Cancer History Count
required: sms:false

Yes-SmokingExposure
type: Class
comment: Individual has been exposed to smoke; requires additional metadata
subclass of: Exposure
subclass of: SmokingExposure
is part of: schema.biothings.io
display name: Yes - Smoking Exposure
required: sms:false
requires dependency: YearsSmoked
requires dependency: PackYearsSmoked
requires dependency: CigarettesperDay
requires dependency: SmokingFrequency
requires dependency: TypeofSmokeExposure
requires dependency: TimebetweenWakingandFirstSmoke
requires dependency: TobaccoSmokingOnsetYear
requires dependency: TobaccoSmokingQuitYear
requires dependency: TobaccoSmokingStatus
requires dependency: TypeofTobaccoUsed
requires dependency: SecondhandSmokeasChild
requires dependency: SmokeExposureDuration
requires dependency: TobaccoUseperDay
requires dependency: SmokelessTobaccoQuitAge

No-SmokingExposure
type: Class
comment: TBD
subclass of: SmokingExposure
is part of: schema.biothings.io
display name: No - Smoking Exposure
required: sms:false

CigarettesperDay
type: Class
comment: The average number of cigarettes smoked per day.
subclass of: Exposure
is part of: schema.biothings.io
display name: Cigarettes per Day
required: sms:false

SmokingFrequency
type: Class
comment: The text term used to generally decribe how often the patient smokes.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Everyday
range includes: Somedays
range includes: Unknown
display name: Smoking Frequency
required: sms:false

TypeofSmokeExposure
type: Class
comment: The text term used to describe the patient's specific type of smoke exposure.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Accidentalbuildingfiresmoke
range includes: Accidentalgrassfiresmoke
range includes: AccidentalfiresmokeNOS
range includes: Accidentalforestfiresmoke
range includes: Accidentalvehiclefiresmoke
range includes: Aircraftsmoke
range includes: Burningtreesmoke
range includes: CoalsmokeNOS
range includes: CookingrelatedsmokeNOS
range includes: ElectroniccigarettesmokeNOS
range includes: Electricalfiresmoke
range includes: Environmentaltobaccosmoke
range includes: Factorysmokestacksmoke
range includes: Fieldburningsmoke
range includes: FiresmokeNOS
range includes: Furnaceorboilersmoke
range includes: Gasburningsmokepropane
range includes: Greasefiresmoke
range includes: Grillingsmoke
range includes: Hashishsmoke
range includes: Indoorcoalburningstoveorfireplacesmoke
range includes: IndoorstoveorfireplacesmokeNOS
range includes: Indoorwoodburningstoveorfireplacesmoke
range includes: Machinesmoke
range includes: Marijuanasmoke
range includes: NoSmokeExposure
range includes: OilburningsmokeKerosene
range includes: OilburningsmokeNOS
range includes: Recreationalfiresmoke
range includes: SmokeexposureNOS
range includes: Smokehousesmoke
range includes: Tobaccosmokecigar
range includes: Tobaccosmokecigarettes
range includes: Tobaccosmokepipe
range includes: Unknown
range includes: Volcanicsmoke
range includes: Wasteburningsmoke
range includes: Woodburningsmokefactory
range includes: WoodburningsmokeNOS
range includes: Workrelatedsmokeartificialsmokemachines
range includes: Workrelatedsmokefirefighting
range includes: Workrelatedsmokefoundry
range includes: Workrelatedsmokegenerators
range includes: Workrelatedsmokemilitary
range includes: WorkrelatedsmokeNOS
range includes: Workrelatedsmokepaintbaking
range includes: Workrelatedsmokeplasticsfactory
range includes: Workrelatedsmokeplumbing
range includes: Workrelatedsmokesoldering/welding
display name: Type of Smoke Exposure
required: sms:false

TimebetweenWakingandFirstSmoke
type: Class
comment: The text term used to describe the approximate amount of time elapsed between the time the patient wakes up in the morning to the time they smoke their first cigarette.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Within5Minutes
range includes: 6-30Minutes
range includes: 31-60Minutes
range includes: After60Minutes
range includes: Unknown
display name: Time between Waking and First Smoke
required: sms:false

TobaccoSmokingOnsetYear
type: Class
comment: The year in which the participant began smoking.
subclass of: Exposure
is part of: schema.biothings.io
display name: Tobacco Smoking Onset Year
required: sms:false

TobaccoSmokingQuitYear
type: Class
comment: The year in which the participant quit smoking.
subclass of: Exposure
is part of: schema.biothings.io
display name: Tobacco Smoking Quit Year
required: sms:false

TobaccoSmokingStatus
type: Class
comment: Category describing current smoking status and smoking history as self-reported by a patient
subclass of: Exposure
is part of: schema.biothings.io
range includes: LifelongNon-Smoker
range includes: CurrentSmoker
range includes: CurrentReformedSmokerfor>15yrs
range includes: CurrentReformedSmokerfor<or=15yrs
range includes: CurrentReformedSmoker
range includes: DurationNotSpecified
range includes: Smokinghistorynotdocumented
range includes: Unknown
range includes: NotReported
display name: Tobacco Smoking Status
required: sms:false

TypeofTobaccoUsed
type: Class
comment: The text term used to describe the specific type of tobacco used by the patient.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Cigarettes
range includes: Cigar
range includes: ElectronicCigarette
range includes: Other
range includes: Pipe
range includes: SmokelessTobacco
range includes: Marijuana
range includes: Unknown
range includes: NotReported
display name: Type of Tobacco Used
required: sms:false

SecondhandSmokeasChild
type: Class
comment: The text term used to indicate whether the patient was exposed to secondhand smoke as a child.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Secondhand Smoke as Child
required: sms:false

SmokeExposureDuration
type: Class
comment: Text term used to describe the length of time the patient was exposed to an environmental factor.
subclass of: Exposure
is part of: schema.biothings.io
range includes: SixWeeksorMore
range includes: Unknown
range includes: NotReported
display name: Smoke Exposure Duration
required: sms:false

TobaccoUseperDay
type: Class
comment: Numeric value that represents the number of times the patient uses tobacco each day.
subclass of: Exposure
is part of: schema.biothings.io
display name: Tobacco Use per Day
required: sms:false

SmokelessTobaccoQuitAge
type: Class
comment: Smokeless tobacco quit age
subclass of: Exposure
is part of: schema.biothings.io
display name: Smokeless Tobacco Quit Age
required: sms:false

Yes-AlcoholExposure
type: Class
comment: Individual has been exposed to alcohol
subclass of: Exposure
subclass of: AlcoholExposure
is part of: schema.biothings.io
display name: Yes - Alcohol Exposure
required: sms:false
requires dependency: AlcoholDaysPerWeek
requires dependency: AlcoholDrinksPerDay
requires dependency: AlcoholHistory
requires dependency: AlcoholIntensity
requires dependency: AlcoholType

No-AlcoholExposure
type: Class
comment: TBD
subclass of: AlcoholExposure
is part of: schema.biothings.io
display name: No - Alcohol Exposure
required: sms:false

AlcoholDaysPerWeek
type: Class
comment: Numeric value used to describe the average number of days each week that a person consumes an alcoholic beverage.
subclass of: Exposure
is part of: schema.biothings.io
display name: Alcohol Days Per Week
required: sms:false
validation rules: int

AlcoholDrinksPerDay
type: Class
comment: Numeric value used to describe the average number of alcoholic beverages a person consumes per day.
subclass of: Exposure
is part of: schema.biothings.io
display name: Alcohol Drinks Per Day
required: sms:false

AlcoholHistory
type: Class
comment: A response to a question that asks whether the participant has consumed at least 12 drinks of any kind of alcoholic beverage in their lifetime.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Yes
range includes: No
range includes: Unknown
range includes: NotReported
display name: Alcohol History
required: sms:false

AlcoholIntensity
type: Class
comment: Category to describe the patient's current level of alcohol use as self-reported by the patient.
subclass of: Exposure
is part of: schema.biothings.io
range includes: Drinker
range includes: HeavyDrinker
range includes: LifelongNon-Drinker
range includes: Non-Drinker
range includes: OccasionalDrinker
range includes: Unknown
range includes: NotReported
display name: Alcohol Intensity
required: sms:false

AlcoholType
type: Class
comment: Type of alcohol use
subclass of: Exposure
is part of: schema.biothings.io
range includes: Beer
range includes: Liquor
range includes: Other
range includes: Wine
range includes: Unknown
range includes: NotReported
display name: Alcohol Type
required: sms:false

Drinker
type: Class
comment: TBD
subclass of: AlcoholIntensity
is part of: schema.biothings.io
display name: Drinker
required: sms:false

HeavyDrinker
type: Class
comment: TBD
subclass of: AlcoholIntensity
is part of: schema.biothings.io
display name: Heavy Drinker
required: sms:false

LifelongNon-Drinker
type: Class
comment: TBD
subclass of: AlcoholIntensity
is part of: schema.biothings.io
display name: Lifelong Non-Drinker
required: sms:false

Non-Drinker
type: Class
comment: TBD
subclass of: AlcoholIntensity
is part of: schema.biothings.io
display name: Non-Drinker
required: sms:false

OccasionalDrinker
type: Class
comment: TBD
subclass of: AlcoholIntensity
is part of: schema.biothings.io
display name: Occasional Drinker
required: sms:false

Beer
type: Class
comment: TBD
subclass of: AlcoholType
is part of: schema.biothings.io
display name: Beer
required: sms:false

Liquor
type: Class
comment: TBD
subclass of: AlcoholType
is part of: schema.biothings.io
display name: Liquor
required: sms:false

Wine
type: Class
comment: TBD
subclass of: AlcoholType
is part of: schema.biothings.io
display name: Wine
required: sms:false

Everyday
type: Class
comment: TBD
subclass of: SmokingFrequency
is part of: schema.biothings.io
display name: Every day
required: sms:false

Somedays
type: Class
comment: TBD
subclass of: SmokingFrequency
is part of: schema.biothings.io
display name: Some days
required: sms:false

SixWeeksorMore
type: Class
comment: TBD
subclass of: SmokeExposureDuration
is part of: schema.biothings.io
display name: Six Weeks or More
required: sms:false

Accidentalbuildingfiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Accidental building fire smoke
required: sms:false

Accidentalgrassfiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Accidental grass fire smoke
required: sms:false

AccidentalfiresmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Accidental fire smoke NOS
required: sms:false

Accidentalforestfiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Accidental forest fire smoke
required: sms:false

Accidentalvehiclefiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Accidental vehicle fire smoke
required: sms:false

Aircraftsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Aircraft smoke
required: sms:false

Burningtreesmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Burning tree smoke
required: sms:false

CoalsmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Coal smoke NOS
required: sms:false

CookingrelatedsmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Cooking related smoke NOS
required: sms:false

ElectroniccigarettesmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Electronic cigarette smoke NOS
required: sms:false

Electricalfiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Electrical fire smoke
required: sms:false

Environmentaltobaccosmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Environmental tobacco smoke
required: sms:false

Factorysmokestacksmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Factory smokestack smoke
required: sms:false

Fieldburningsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Field burning smoke
required: sms:false

FiresmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Fire smoke NOS
required: sms:false

Furnaceorboilersmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Furnace or boiler smoke
required: sms:false

Gasburningsmokepropane
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Gas burning smoke propane
required: sms:false

Greasefiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Grease fire smoke
required: sms:false

Grillingsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Grilling smoke
required: sms:false

Hashishsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Hashish smoke
required: sms:false

Indoorcoalburningstoveorfireplacesmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Indoor coal burning stove or fireplace smoke
required: sms:false

IndoorstoveorfireplacesmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Indoor stove or fireplace smoke NOS
required: sms:false

Indoorwoodburningstoveorfireplacesmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Indoor wood burning stove or fireplace smoke
required: sms:false

Machinesmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Machine smoke
required: sms:false

Marijuanasmoke
type: Class
comment: Marijuana smoke exposure
subclass of: Exposure
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Marijuana smoke
required: sms:false
requires dependency: MarijuanaUsePerWeek

NoSmokeExposure
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: No Smoke Exposure
required: sms:false

OilburningsmokeKerosene
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Oil burning smoke Kerosene
required: sms:false

OilburningsmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Oil burning smoke NOS
required: sms:false

Recreationalfiresmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Recreational fire smoke
required: sms:false

SmokeexposureNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Smoke exposure NOS
required: sms:false

Smokehousesmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Smokehouse smoke
required: sms:false

Tobaccosmokecigar
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Tobacco smoke cigar
required: sms:false

Tobaccosmokecigarettes
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Tobacco smoke cigarettes
required: sms:false

Tobaccosmokepipe
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Tobacco smoke pipe
required: sms:false

Volcanicsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Volcanic smoke
required: sms:false

Wasteburningsmoke
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Waste burning smoke
required: sms:false

Woodburningsmokefactory
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Wood burning smoke factory
required: sms:false

WoodburningsmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Wood burning smoke NOS
required: sms:false

Workrelatedsmokeartificialsmokemachines
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke artificial smoke machines
required: sms:false

Workrelatedsmokefirefighting
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke fire fighting
required: sms:false

Workrelatedsmokefoundry
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke foundry
required: sms:false

Workrelatedsmokegenerators
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke generators
required: sms:false

Workrelatedsmokemilitary
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke military
required: sms:false

WorkrelatedsmokeNOS
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke NOS
required: sms:false

Workrelatedsmokepaintbaking
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke paint baking
required: sms:false

Workrelatedsmokeplasticsfactory
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke plastics factory
required: sms:false

Workrelatedsmokeplumbing
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke plumbing
required: sms:false

Workrelatedsmokesoldering/welding
type: Class
comment: TBD
subclass of: TypeofSmokeExposure
is part of: schema.biothings.io
display name: Workrelated smoke soldering/welding
required: sms:false

MarijuanaUsePerWeek
type: Class
comment: Numeric value that represents the number of times the patient uses marijuana each day.
subclass of: Exposure
is part of: schema.biothings.io
display name: Marijuana Use Per Week
required: sms:false

Within5Minutes
type: Class
comment: TBD
subclass of: TimebetweenWakingandFirstSmoke
is part of: schema.biothings.io
display name: Within 5 Minutes
required: sms:false

6-30Minutes
type: Class
comment: TBD
subclass of: TimebetweenWakingandFirstSmoke
is part of: schema.biothings.io
display name: 6-30 Minutes
required: sms:false

31-60Minutes
type: Class
comment: TBD
subclass of: TimebetweenWakingandFirstSmoke
is part of: schema.biothings.io
display name: 31-60 Minutes
required: sms:false

After60Minutes
type: Class
comment: TBD
subclass of: TimebetweenWakingandFirstSmoke
is part of: schema.biothings.io
display name: After 60 Minutes
required: sms:false

LifelongNon-Smoker
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Lifelong Non-Smoker
required: sms:false

CurrentSmoker
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Current Smoker
required: sms:false

CurrentReformedSmokerfor>15yrs
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Current Reformed Smoker for > 15 yrs
required: sms:false

CurrentReformedSmokerfor<or=15yrs
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Current Reformed Smoker for < or = 15 yrs
required: sms:false

CurrentReformedSmoker
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Current Reformed Smoker
required: sms:false

DurationNotSpecified
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Duration Not Specified
required: sms:false

Smokinghistorynotdocumented
type: Class
comment: TBD
subclass of: TobaccoSmokingStatus
is part of: schema.biothings.io
display name: Smoking history not documented
required: sms:false

Cigarettes
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Cigarettes
required: sms:false

Cigar
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Cigar
required: sms:false

ElectronicCigarette
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Electronic Cigarette
required: sms:false

Pipe
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Pipe
required: sms:false

SmokelessTobacco
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Smokeless Tobacco
required: sms:false

Marijuana
type: Class
comment: TBD
subclass of: TypeofTobaccoUsed
is part of: schema.biothings.io
display name: Marijuana
required: sms:false

AbdominalDistension
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Abdominal Distension
required: sms:false

AbdominalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Abdominal Infection
required: sms:false

AbdominalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Abdominal Pain
required: sms:false

AbdominalSoftTissueNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Abdominal Soft Tissue Necrosis
required: sms:false

AbducensNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Abducens Nerve Disorder
required: sms:false

AccessoryNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Accessory Nerve Disorder
required: sms:false

Acidosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Acidosis
required: sms:false

AcousticNerveDisorderNOS
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Acoustic Nerve Disorder NOS
required: sms:false

ActivatedPartialThromboplastinTimeProlonged
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Activated Partial Thromboplastin Time Prolonged
required: sms:false

AcuteCoronarySyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Acute Coronary Syndrome
required: sms:false

AcuteKidneyInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Acute Kidney Injury
required: sms:false

AdrenalInsufficiency
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Adrenal Insufficiency
required: sms:false

AdultRespiratoryDistressSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Adult Respiratory Distress Syndrome
required: sms:false

Agitation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Agitation
required: sms:false

Akathisia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Akathisia
required: sms:false

AlanineAminotransferaseIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Alanine Aminotransferase Increased
required: sms:false

AlcoholIntolerance
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Alcohol Intolerance
required: sms:false

AlkalinePhosphataseIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Alkaline Phosphatase Increased
required: sms:false

Alkalosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Alkalosis
required: sms:false

AllergicReaction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Allergic Reaction
required: sms:false

AllergicRhinitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Allergic Rhinitis
required: sms:false

Alopecia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Alopecia
required: sms:false

Amnesia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Amnesia
required: sms:false

AnalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Fistula
required: sms:false

AnalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Hemorrhage
required: sms:false

AnalMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Mucositis
required: sms:false

AnalNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Necrosis
required: sms:false

AnalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Pain
required: sms:false

AnalStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Stenosis
required: sms:false

AnalUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anal Ulcer
required: sms:false

Anaphylaxis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anaphylaxis
required: sms:false

Anemia
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anemia
required: sms:false

AnkleFracture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ankle Fracture
required: sms:false

AnorectalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anorectal Infection
required: sms:false

Anorexia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anorexia
required: sms:false

Anorgasmia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anorgasmia
required: sms:false

Anxiety
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Anxiety
required: sms:false

AorticInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Aortic Injury
required: sms:false

AorticValveDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Aortic Valve Disease
required: sms:false

Aphonia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Aphonia
required: sms:false

Apnea
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Apnea
required: sms:false

Appendicitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Appendicitis
required: sms:false

AppendicitisPerforated
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Appendicitis Perforated
required: sms:false

Arachnoiditis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Arachnoiditis
required: sms:false

ArterialInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Arterial Injury
required: sms:false

ArteritisInfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Arteritis Infective
required: sms:false

Arthralgia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Arthralgia
required: sms:false

Arthritis
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Arthritis
required: sms:false

Ascites
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ascites
required: sms:false

AspartateAminotransferaseIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Aspartate Aminotransferase Increased
required: sms:false

Aspiration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Aspiration
required: sms:false

Asystole
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Asystole
required: sms:false

Ataxia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ataxia
required: sms:false

Atelectasis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Atelectasis
required: sms:false

AtrialFibrillation
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Atrial Fibrillation
required: sms:false

AtrialFlutter
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Atrial Flutter
required: sms:false

AtrioventricularBlockComplete
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Atrioventricular Block Complete
required: sms:false

AtrioventricularBlockFirstDegree
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Atrioventricular Block First Degree
required: sms:false

AutoimmuneDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Autoimmune Disorder
required: sms:false

AvascularNecrosis
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Avascular Necrosis
required: sms:false

Azoospermia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Azoospermia
required: sms:false

BackPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Back Pain
required: sms:false

BileDuctStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bile Duct Stenosis
required: sms:false

BiliaryAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Biliary Anastomotic Leak
required: sms:false

BiliaryFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Biliary Fistula
required: sms:false

BiliaryTractInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Biliary Tract Infection
required: sms:false

BladderAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bladder Anastomotic Leak
required: sms:false

BladderInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bladder Infection
required: sms:false

BladderPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bladder Perforation
required: sms:false

BladderSpasm
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bladder Spasm
required: sms:false

Bloating
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bloating
required: sms:false

BloodandLymphaticSystemDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood and Lymphatic System Disorders Other
required: sms:false

BloodAntidiureticHormoneAbnormal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood Antidiuretic Hormone Abnormal
required: sms:false

BloodBilirubinIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood Bilirubin Increased
required: sms:false

BloodCorticotrophinDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood Corticotrophin Decreased
required: sms:false

BloodGonadotrophinAbnormal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood Gonadotrophin Abnormal
required: sms:false

BloodProlactinAbnormal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blood Prolactin Abnormal
required: sms:false

BlurredVision
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Blurred Vision
required: sms:false

BodyOdor
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Body Odor
required: sms:false

BoneInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bone Infection
required: sms:false

BoneMarrowHypocellular
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bone Marrow Hypocellular
required: sms:false

BonePain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bone Pain
required: sms:false

BrachialPlexopathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Brachial Plexopathy
required: sms:false

BreastAtrophy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Breast Atrophy
required: sms:false

BreastInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Breast Infection
required: sms:false

BreastPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Breast Pain
required: sms:false

BronchialFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchial Fistula
required: sms:false

BronchialInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchial Infection
required: sms:false

BronchialObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchial Obstruction
required: sms:false

BronchialStricture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchial Stricture
required: sms:false

BronchopleuralFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchopleural Fistula
required: sms:false

BronchopulmonaryHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchopulmonary Hemorrhage
required: sms:false

Bronchospasm
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bronchospasm
required: sms:false

Bruising
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bruising
required: sms:false

BullousDermatitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Bullous Dermatitis
required: sms:false

Burn
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Burn
required: sms:false

ButtockPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Buttock Pain
required: sms:false

CapillaryLeakSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Capillary Leak Syndrome
required: sms:false

CarbonMonoxideDiffusingCapacityDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Carbon Monoxide Diffusing Capacity Decreased
required: sms:false

CardiacArrest
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cardiac Arrest
required: sms:false

CardiacDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cardiac Disorders Other
required: sms:false

CardiacTroponinIIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cardiac Troponin I Increased
required: sms:false

CardiacTroponinTIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cardiac Troponin T Increased
required: sms:false

Cataract
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cataract
required: sms:false

CatheterRelatedInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Catheter Related Infection
required: sms:false

CD4LymphocytesDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: CD4 Lymphocytes Decreased
required: sms:false

CecalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cecal Hemorrhage
required: sms:false

CecalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cecal Infection
required: sms:false

CentralNervousSystemNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Central Nervous System Necrosis
required: sms:false

CerebrospinalFluidLeakage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cerebrospinal Fluid Leakage
required: sms:false

CervicitisInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cervicitis Infection
required: sms:false

Cheilitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cheilitis
required: sms:false

ChestPainCardiac
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Chest Pain Cardiac
required: sms:false

ChestWallPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Chest Wall Pain
required: sms:false

Chills
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Chills
required: sms:false

Cholecystitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cholecystitis
required: sms:false

CholesterolHigh
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cholesterol High
required: sms:false

ChronicKidneyDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Chronic Kidney Disease
required: sms:false

Chylothorax
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Chylothorax
required: sms:false

CognitiveDisturbance
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cognitive Disturbance
required: sms:false

Colitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colitis
required: sms:false

ColonicFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Fistula
required: sms:false

ColonicHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Hemorrhage
required: sms:false

ColonicObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Obstruction
required: sms:false

ColonicPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Perforation
required: sms:false

ColonicStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Stenosis
required: sms:false

ColonicUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Colonic Ulcer
required: sms:false

ConcentrationImpairment
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Concentration Impairment
required: sms:false

ConductionDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Conduction Disorder
required: sms:false

Confusion
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Confusion
required: sms:false

Congenital
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Congenital
required: sms:false

FamilialandGeneticDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Familial and Genetic Disorders Other
required: sms:false

Conjunctivitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Conjunctivitis
required: sms:false

ConjunctivitisInfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Conjunctivitis Infective
required: sms:false

Constipation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Constipation
required: sms:false

ConstrictivePericarditis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Constrictive Pericarditis
required: sms:false

CornealInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Corneal Infection
required: sms:false

CornealUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Corneal Ulcer
required: sms:false

Cough
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cough
required: sms:false

CPKIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: CPK Increased
required: sms:false

CranialNerveInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cranial Nerve Infection
required: sms:false

CreatinineIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Creatinine Increased
required: sms:false

Cushingoid
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cushingoid
required: sms:false

CystitisNoninfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cystitis Noninfective
required: sms:false

CytokineReleaseSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Cytokine Release Syndrome
required: sms:false

DeathNeonatal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Death Neonatal
required: sms:false

DeathNOS
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Death NOS
required: sms:false

Dehydration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dehydration
required: sms:false

DelayedOrgasm
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Delayed Orgasm
required: sms:false

DelayedPuberty
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Delayed Puberty
required: sms:false

Delirium
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Delirium
required: sms:false

Delusions
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Delusions
required: sms:false

DentalCaries
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dental Caries
required: sms:false

DepressedLevelofConsciousness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Depressed Level of Consciousness
required: sms:false

Depression
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Depression
required: sms:false

DermatitisRadiation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dermatitis Radiation
required: sms:false

DeviceRelatedInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Device Related Infection
required: sms:false

Diarrhea
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Diarrhea
required: sms:false

DisseminatedIntravascularCoagulation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Disseminated Intravascular Coagulation
required: sms:false

Dizziness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dizziness
required: sms:false

DryEye
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dry Eye
required: sms:false

DryMouth
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dry Mouth
required: sms:false

DrySkin
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dry Skin
required: sms:false

DuodenalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Fistula
required: sms:false

DuodenalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Hemorrhage
required: sms:false

DuodenalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Infection
required: sms:false

DuodenalObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Obstruction
required: sms:false

DuodenalPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Perforation
required: sms:false

DuodenalStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Stenosis
required: sms:false

DuodenalUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Duodenal Ulcer
required: sms:false

Dysarthria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dysarthria
required: sms:false

Dysesthesia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dysesthesia
required: sms:false

Dysgeusia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dysgeusia
required: sms:false

Dysmenorrhea
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dysmenorrhea
required: sms:false

Dyspareunia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dyspareunia
required: sms:false

Dyspepsia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dyspepsia
required: sms:false

Dysphagia
type: Class
comment: TBD
subclass of: CurrentLungCancerSymptoms
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: dysphagia
required: sms:false

Dysphasia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Dysphasia
required: sms:false

Dyspnea
type: Class
comment: TBD
subclass of: CurrentLungCancerSymptoms
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: dyspnea
required: sms:false

EarandLabyrinthDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ear and Labyrinth Disorders Other
required: sms:false

EarPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ear Pain
required: sms:false

EdemaCerebral
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Edema Cerebral
required: sms:false

EdemaFace
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Edema Face
required: sms:false

EdemaLimbs
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Edema Limbs
required: sms:false

EdemaTrunk
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Edema Trunk
required: sms:false

EjaculationDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ejaculation Disorder
required: sms:false

EjectionFractionDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ejection Fraction Decreased
required: sms:false

ElectrocardiogramQTCorrectedIntervalProlonged
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Electrocardiogram QT Corrected Interval Prolonged
required: sms:false

EncephalitisInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Encephalitis Infection
required: sms:false

EncephalomyelitisInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Encephalomyelitis Infection
required: sms:false

Encephalopathy
type: Class
comment: TBD
subclass of: AIDSRiskFactors
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Encephalopathy
required: sms:false

EndocarditisInfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Endocarditis Infective
required: sms:false

EndocrineDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Endocrine Disorders Other
required: sms:false

Endophthalmitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Endophthalmitis
required: sms:false

Enterocolitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Enterocolitis
required: sms:false

EnterocolitisInfectious
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Enterocolitis Infectious
required: sms:false

EnterovesicalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Enterovesical Fistula
required: sms:false

Epistaxis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Epistaxis
required: sms:false

ErectileDysfunction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Erectile Dysfunction
required: sms:false

ErythemaMultiforme
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Erythema Multiforme
required: sms:false

Erythroderma
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Erythroderma
required: sms:false

EsophagealAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Anastomotic Leak
required: sms:false

EsophagealFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Fistula
required: sms:false

EsophagealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Hemorrhage
required: sms:false

EsophagealInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Infection
required: sms:false

EsophagealNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Necrosis
required: sms:false

EsophagealObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Obstruction
required: sms:false

EsophagealPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Pain
required: sms:false

EsophagealPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Perforation
required: sms:false

EsophagealStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Stenosis
required: sms:false

EsophagealUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Ulcer
required: sms:false

EsophagealVaricesHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophageal Varices Hemorrhage
required: sms:false

Esophagitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Esophagitis
required: sms:false

Euphoria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Euphoria
required: sms:false

Exostosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Exostosis
required: sms:false

ExternalEarInflammation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: External Ear Inflammation
required: sms:false

ExternalEarPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: External Ear Pain
required: sms:false

ExtraocularMuscleParesis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Extraocular Muscle Paresis
required: sms:false

ExtrapyramidalDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Extrapyramidal Disorder
required: sms:false

EyeDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Eye Disorders Other
required: sms:false

EyeInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Eye Infection
required: sms:false

EyePain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Eye Pain
required: sms:false

EyelidFunctionDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Eyelid Function Disorder
required: sms:false

FacialMuscleWeakness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Facial Muscle Weakness
required: sms:false

FacialNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Facial Nerve Disorder
required: sms:false

FacialPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Facial Pain
required: sms:false

Fall
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fall
required: sms:false

FallopianTubeAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fallopian Tube Anastomotic Leak
required: sms:false

FallopianTubeObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fallopian Tube Obstruction
required: sms:false

FallopianTubePerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fallopian Tube Perforation
required: sms:false

FallopianTubeStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fallopian Tube Stenosis
required: sms:false

FatAtrophy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fat Atrophy
required: sms:false

Fatigue
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fatigue
required: sms:false

FebrileNeutropenia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Febrile Neutropenia
required: sms:false

FecalIncontinence
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fecal Incontinence
required: sms:false

FemaleGenitalTractFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Female Genital Tract Fistula
required: sms:false

FeminizationAcquired
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Feminization Acquired
required: sms:false

FetalDeath
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fetal Death
required: sms:false

FetalGrowthRetardation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fetal Growth Retardation
required: sms:false

Fever
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fever
required: sms:false

FibrinogenDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fibrinogen Decreased
required: sms:false

FibrosisDeepConnectiveTissue
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fibrosis Deep Connective Tissue
required: sms:false

FlankPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Flank Pain
required: sms:false

FlashingLights
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Flashing Lights
required: sms:false

Flatulence
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Flatulence
required: sms:false

Floaters
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Floaters
required: sms:false

FluLikeSymptoms
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Flu Like Symptoms
required: sms:false

Flushing
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Flushing
required: sms:false

ForcedExpiratoryVolumeDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Forced Expiratory Volume Decreased
required: sms:false

Fracture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Fracture
required: sms:false

GaitDisturbance
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gait Disturbance
required: sms:false

GallbladderFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Fistula
required: sms:false

GallbladderInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Infection
required: sms:false

GallbladderNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Necrosis
required: sms:false

GallbladderObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Obstruction
required: sms:false

GallbladderPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Pain
required: sms:false

GallbladderPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gallbladder Perforation
required: sms:false

GastricAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Anastomotic Leak
required: sms:false

GastricFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Fistula
required: sms:false

GastricHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Hemorrhage
required: sms:false

GastricNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Necrosis
required: sms:false

GastricPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Perforation
required: sms:false

GastricStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Stenosis
required: sms:false

GastricUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastric Ulcer
required: sms:false

Gastritis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastritis
required: sms:false

GastroesophagealRefluxDisease
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastroesophageal Reflux Disease
required: sms:false

GastrointestinalAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastrointestinal Anastomotic Leak
required: sms:false

GastrointestinalDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastrointestinal Disorders Other
required: sms:false

GastrointestinalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastrointestinal Fistula
required: sms:false

GastrointestinalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastrointestinal Pain
required: sms:false

GastrointestinalStomaNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastrointestinal Stoma Necrosis
required: sms:false

Gastroparesis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gastroparesis
required: sms:false

GeneralDisordersandAdministrationSiteConditionsOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: General Disorders and Administration Site Conditions Other
required: sms:false

GeneralizedMuscleWeakness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Generalized Muscle Weakness
required: sms:false

GenitalEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Genital Edema
required: sms:false

GGTIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: GGT Increased
required: sms:false

GingivalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gingival Pain
required: sms:false

Glaucoma
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Glaucoma
required: sms:false

GlossopharyngealNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Glossopharyngeal Nerve Disorder
required: sms:false

GlucoseIntolerance
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Glucose Intolerance
required: sms:false

GrowthAccelerated
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Growth Accelerated
required: sms:false

GrowthHormoneAbnormal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Growth Hormone Abnormal
required: sms:false

GrowthSuppression
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Growth Suppression
required: sms:false

GumInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gum Infection
required: sms:false

Gynecomastia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Gynecomastia
required: sms:false

Hallucinations
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hallucinations
required: sms:false

HaptoglobinDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Haptoglobin Decreased
required: sms:false

HeadSoftTissueNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Head Soft Tissue Necrosis
required: sms:false

Headache
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Headache
required: sms:false

HearingImpaired
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hearing Impaired
required: sms:false

HeartFailure
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Heart Failure
required: sms:false

Hematoma
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hematoma
required: sms:false

Hematosalpinx
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hematosalpinx
required: sms:false

Hematuria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hematuria
required: sms:false

HemoglobinIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemoglobin Increased
required: sms:false

Hemoglobinuria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemoglobinuria
required: sms:false

Hemolysis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemolysis
required: sms:false

HemolyticUremicSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemolytic Uremic Syndrome
required: sms:false

HemorrhoidalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemorrhoidal Hemorrhage
required: sms:false

Hemorrhoids
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hemorrhoids
required: sms:false

HepaticFailure
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatic Failure
required: sms:false

HepaticHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatic Hemorrhage
required: sms:false

HepaticInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatic Infection
required: sms:false

HepaticNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatic Necrosis
required: sms:false

HepaticPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatic Pain
required: sms:false

HepatitisViral
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatitis Viral
required: sms:false

HepatobiliaryDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hepatobiliary Disorders Other
required: sms:false

Hiccups
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hiccups
required: sms:false

HipFracture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hip Fracture
required: sms:false

Hirsutism
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hirsutism
required: sms:false

Hoarseness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hoarseness
required: sms:false

HotFlashes
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hot Flashes
required: sms:false

Hydrocephalus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hydrocephalus
required: sms:false

Hypercalcemia
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypercalcemia
required: sms:false

Hyperglycemia
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperglycemia
required: sms:false

Hyperhidrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperhidrosis
required: sms:false

Hyperkalemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperkalemia
required: sms:false

Hypermagnesemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypermagnesemia
required: sms:false

Hypernatremia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypernatremia
required: sms:false

Hyperparathyroidism
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperparathyroidism
required: sms:false

Hypersomnia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypersomnia
required: sms:false

Hypertension
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypertension
required: sms:false

Hyperthyroidism
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperthyroidism
required: sms:false

Hypertrichosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypertrichosis
required: sms:false

Hypertriglyceridemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypertriglyceridemia
required: sms:false

Hyperuricemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyperuricemia
required: sms:false

Hypoalbuminemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypoalbuminemia
required: sms:false

Hypocalcemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypocalcemia
required: sms:false

HypoglossalNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypoglossal Nerve Disorder
required: sms:false

Hypoglycemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypoglycemia
required: sms:false

Hypohidrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypohidrosis
required: sms:false

Hypokalemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypokalemia
required: sms:false

Hypomagnesemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypomagnesemia
required: sms:false

Hyponatremia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hyponatremia
required: sms:false

Hypoparathyroidism
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypoparathyroidism
required: sms:false

Hypophosphatemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypophosphatemia
required: sms:false

Hypotension
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypotension
required: sms:false

Hypothermia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypothermia
required: sms:false

Hypothyroidism
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypothyroidism
required: sms:false

Hypoxia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Hypoxia
required: sms:false

IlealFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Fistula
required: sms:false

IlealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Hemorrhage
required: sms:false

IlealObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Obstruction
required: sms:false

IlealPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Perforation
required: sms:false

IlealStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Stenosis
required: sms:false

IlealUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileal Ulcer
required: sms:false

Ileus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ileus
required: sms:false

ImmuneSystemDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Immune System Disorders Other
required: sms:false

InfectionsandInfestationsOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Infections and Infestations Other
required: sms:false

InfectiveMyositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Infective Myositis
required: sms:false

InfusionRelatedReaction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Infusion Related Reaction
required: sms:false

InfusionSiteExtravasation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Infusion Site Extravasation
required: sms:false

InjectionSiteReaction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injection Site Reaction
required: sms:false

InjurytoCarotidArtery
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injury to Carotid Artery
required: sms:false

InjurytoInferiorVenaCava
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injury to Inferior Vena Cava
required: sms:false

InjurytoJugularVein
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injury to Jugular Vein
required: sms:false

InjurytoSuperiorVenaCava
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injury to Superior Vena Cava
required: sms:false

Injury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Injury
required: sms:false

PoisoningandProceduralComplicationsOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Poisoning and Procedural Complications Other
required: sms:false

INRIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: INR Increased
required: sms:false

Insomnia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Insomnia
required: sms:false

IntestinalStomaLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intestinal Stoma Leak
required: sms:false

IntestinalStomaObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intestinal Stoma Obstruction
required: sms:false

IntestinalStomaSiteBleeding
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intestinal Stoma Site Bleeding
required: sms:false

Intra-AbdominalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intra-Abdominal Hemorrhage
required: sms:false

IntracranialHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intracranial Hemorrhage
required: sms:false

IntraoperativeArterialInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Arterial Injury
required: sms:false

IntraoperativeBreastInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Breast Injury
required: sms:false

IntraoperativeCardiacInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Cardiac Injury
required: sms:false

IntraoperativeEarInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Ear Injury
required: sms:false

IntraoperativeEndocrineInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Endocrine Injury
required: sms:false

IntraoperativeGastrointestinalInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Gastrointestinal Injury
required: sms:false

IntraoperativeHeadandNeckInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Head and Neck Injury
required: sms:false

IntraoperativeHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Hemorrhage
required: sms:false

IntraoperativeHepatobiliaryInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Hepatobiliary Injury
required: sms:false

IntraoperativeMusculoskeletalInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Musculoskeletal Injury
required: sms:false

IntraoperativeNeurologicalInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Neurological Injury
required: sms:false

IntraoperativeOcularInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Ocular Injury
required: sms:false

IntraoperativeRenalInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Renal Injury
required: sms:false

IntraoperativeReproductiveTractInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Reproductive Tract Injury
required: sms:false

IntraoperativeRespiratoryInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Respiratory Injury
required: sms:false

IntraoperativeSkinInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Skin Injury
required: sms:false

IntraoperativeSplenicInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Splenic Injury
required: sms:false

IntraoperativeUrinaryInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Urinary Injury
required: sms:false

IntraoperativeVenousInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Intraoperative Venous Injury
required: sms:false

InvestigationsOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Investigations Other
required: sms:false

IronOverload
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Iron Overload
required: sms:false

IrregularMenstruation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Irregular Menstruation
required: sms:false

Irritability
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Irritability
required: sms:false

IschemiaCerebrovascular
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ischemia Cerebrovascular
required: sms:false

IVthNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: IVth Nerve Disorder
required: sms:false

JejunalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Fistula
required: sms:false

JejunalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Hemorrhage
required: sms:false

JejunalObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Obstruction
required: sms:false

JejunalPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Perforation
required: sms:false

JejunalStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Stenosis
required: sms:false

JejunalUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Jejunal Ulcer
required: sms:false

JointEffusion
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Joint Effusion
required: sms:false

JointInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Joint Infection
required: sms:false

JointRangeofMotionDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Joint Range of Motion Decreased
required: sms:false

JointRangeofMotionDecreasedCervicalSpine
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Joint Range of Motion Decreased Cervical Spine
required: sms:false

JointRangeofMotionDecreasedLumbarSpine
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Joint Range of Motion Decreased Lumbar Spine
required: sms:false

Keratitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Keratitis
required: sms:false

KidneyAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Kidney Anastomotic Leak
required: sms:false

KidneyInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Kidney Infection
required: sms:false

Kyphosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Kyphosis
required: sms:false

LactationDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lactation Disorder
required: sms:false

LargeIntestinalAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Large Intestinal Anastomotic Leak
required: sms:false

LaryngealEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Edema
required: sms:false

LaryngealFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Fistula
required: sms:false

LaryngealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Hemorrhage
required: sms:false

LaryngealInflammation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Inflammation
required: sms:false

LaryngealMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Mucositis
required: sms:false

LaryngealObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Obstruction
required: sms:false

LaryngealStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngeal Stenosis
required: sms:false

Laryngitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngitis
required: sms:false

LaryngopharyngealDysesthesia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngopharyngeal Dysesthesia
required: sms:false

Laryngospasm
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Laryngospasm
required: sms:false

LeftVentricularSystolicDysfunction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Left Ventricular Systolic Dysfunction
required: sms:false

Lethargy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lethargy
required: sms:false

LeukemiaSecondarytoOncologyChemotherapy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Leukemia Secondary to Oncology Chemotherapy
required: sms:false

Leukocytosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Leukocytosis
required: sms:false

Leukoencephalopathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Leukoencephalopathy
required: sms:false

LibidoDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Libido Decreased
required: sms:false

LibidoIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Libido Increased
required: sms:false

LipInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lip Infection
required: sms:false

LipPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lip Pain
required: sms:false

LipaseIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lipase Increased
required: sms:false

Lipohypertrophy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lipohypertrophy
required: sms:false

LocalizedEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Localized Edema
required: sms:false

Lordosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lordosis
required: sms:false

LowerGastrointestinalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lower Gastrointestinal Hemorrhage
required: sms:false

LungInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lung Infection
required: sms:false

LymphGlandInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymph Gland Infection
required: sms:false

LymphLeakage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymph Leakage
required: sms:false

LymphNodePain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymph Node Pain
required: sms:false

Lymphedema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymphedema
required: sms:false

Lymphocele
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymphocele
required: sms:false

LymphocyteCountDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymphocyte Count Decreased
required: sms:false

LymphocyteCountIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Lymphocyte Count Increased
required: sms:false

Malabsorption
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Malabsorption
required: sms:false

Malaise
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Malaise
required: sms:false

Mania
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mania
required: sms:false

MediastinalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mediastinal Hemorrhage
required: sms:false

MediastinalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mediastinal Infection
required: sms:false

MemoryImpairment
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Memory Impairment
required: sms:false

Meningismus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Meningismus
required: sms:false

Meningitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Meningitis
required: sms:false

Menopause
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Menopause
required: sms:false

Menorrhagia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Menorrhagia
required: sms:false

MetabolismandNutritionDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Metabolism and Nutrition Disorders Other
required: sms:false

MiddleEarInflammation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Middle Ear Inflammation
required: sms:false

MitralValveDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mitral Valve Disease
required: sms:false

Mobitz(Type)IIAtrioventricularBlock
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mobitz (Type) II Atrioventricular Block
required: sms:false

MobitzTypeI
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mobitz Type I
required: sms:false

MovementsInvoluntary
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Movements Involuntary
required: sms:false

MucosalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mucosal Infection
required: sms:false

MucositisOral
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Mucositis Oral
required: sms:false

Multi-OrganFailure
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Multi-Organ Failure
required: sms:false

MuscleWeaknessLeft-Sided
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Muscle Weakness Left-Sided
required: sms:false

MuscleWeaknessLowerLimb
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Muscle Weakness Lower Limb
required: sms:false

MuscleWeaknessRight-Sided
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Muscle Weakness Right-Sided
required: sms:false

MuscleWeaknessTrunk
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Muscle Weakness Trunk
required: sms:false

MuscleWeaknessUpperLimb
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Muscle Weakness Upper Limb
required: sms:false

MusculoskeletalandConnectiveTissueDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Musculoskeletal and Connective Tissue Disorders Other
required: sms:false

MusculoskeletalDeformity
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Musculoskeletal Deformity
required: sms:false

Myalgia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myalgia
required: sms:false

Myelitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myelitis
required: sms:false

MyelodysplasticSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myelodysplastic Syndrome
required: sms:false

MyocardialInfarction
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myocardial Infarction
required: sms:false

Myocarditis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myocarditis
required: sms:false

Myositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Myositis
required: sms:false

NailDiscoloration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nail Discoloration
required: sms:false

NailInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nail Infection
required: sms:false

NailLoss
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nail Loss
required: sms:false

NailRidging
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nail Ridging
required: sms:false

NasalCongestion
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nasal Congestion
required: sms:false

Nausea
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nausea
required: sms:false

NeckEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neck Edema
required: sms:false

NeckPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neck Pain
required: sms:false

NeckSoftTissueNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neck Soft Tissue Necrosis
required: sms:false

NeoplasmsBenign
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neoplasms Benign
required: sms:false

http://schema.biothings.io/MalignantandUnspecified(InclCystsandPolyps)Other
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Malignant and Unspecified (Incl Cysts and Polyps) Other
required: sms:false

NervousSystemDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nervous System Disorders Other
required: sms:false

Neuralgia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neuralgia
required: sms:false

NeutrophilCountDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Neutrophil Count Decreased
required: sms:false

NightBlindness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Night Blindness
required: sms:false

NippleDeformity
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nipple Deformity
required: sms:false

Non-CardiacChestPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Non-Cardiac Chest Pain
required: sms:false

Nystagmus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Nystagmus
required: sms:false

Obesity
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Obesity
required: sms:false

ObstructionGastric
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Obstruction Gastric
required: sms:false

OculomotorNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oculomotor Nerve Disorder
required: sms:false

OlfactoryNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Olfactory Nerve Disorder
required: sms:false

Oligospermia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oligospermia
required: sms:false

OpticNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Optic Nerve Disorder
required: sms:false

OralCavityFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oral Cavity Fistula
required: sms:false

OralDysesthesia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oral Dysesthesia
required: sms:false

OralHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oral Hemorrhage
required: sms:false

OralPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Oral Pain
required: sms:false

OsteonecrosisofJaw
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Osteonecrosis of Jaw
required: sms:false

Osteoporosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Osteoporosis
required: sms:false

OtitisExterna
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Otitis Externa
required: sms:false

OtitisMedia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Otitis Media
required: sms:false

OvarianHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ovarian Hemorrhage
required: sms:false

OvarianInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ovarian Infection
required: sms:false

OvarianRupture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ovarian Rupture
required: sms:false

OvulationPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ovulation Pain
required: sms:false

Pain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pain
required: sms:false

PaininExtremity
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pain in Extremity
required: sms:false

PainofSkin
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pain of Skin
required: sms:false

Palmar-PlantarErythrodysesthesiaSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Palmar-Plantar Erythrodysesthesia Syndrome
required: sms:false

Palpitations
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Palpitations
required: sms:false

PancreasInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreas Infection
required: sms:false

PancreaticAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Anastomotic Leak
required: sms:false

PancreaticDuctStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Duct Stenosis
required: sms:false

PancreaticEnzymesDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Enzymes Decreased
required: sms:false

PancreaticFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Fistula
required: sms:false

PancreaticHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Hemorrhage
required: sms:false

PancreaticNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatic Necrosis
required: sms:false

Pancreatitis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pancreatitis
required: sms:false

Papilledema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Papilledema
required: sms:false

PapulopustularRash
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Papulopustular Rash
required: sms:false

Paresthesia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Paresthesia
required: sms:false

Paronychia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Paronychia
required: sms:false

ParoxysmalAtrialTachycardia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Paroxysmal Atrial Tachycardia
required: sms:false

PelvicFloorMuscleWeakness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pelvic Floor Muscle Weakness
required: sms:false

PelvicInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pelvic Infection
required: sms:false

PelvicPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pelvic Pain
required: sms:false

PelvicSoftTissueNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pelvic Soft Tissue Necrosis
required: sms:false

PenileInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Penile Infection
required: sms:false

PenilePain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Penile Pain
required: sms:false

PerforationBileDuct
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Perforation Bile Duct
required: sms:false

PericardialEffusion
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pericardial Effusion
required: sms:false

PericardialTamponade
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pericardial Tamponade
required: sms:false

Pericarditis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pericarditis
required: sms:false

PerinealPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Perineal Pain
required: sms:false

PeriodontalDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Periodontal Disease
required: sms:false

PeriorbitalEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Periorbital Edema
required: sms:false

PeriorbitalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Periorbital Infection
required: sms:false

PeripheralIschemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peripheral Ischemia
required: sms:false

PeripheralMotorNeuropathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peripheral Motor Neuropathy
required: sms:false

PeripheralNerveInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peripheral Nerve Infection
required: sms:false

PeripheralSensoryNeuropathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peripheral Sensory Neuropathy
required: sms:false

PeritonealInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peritoneal Infection
required: sms:false

PeritonealNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Peritoneal Necrosis
required: sms:false

PersonalityChange
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Personality Change
required: sms:false

PhantomPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Phantom Pain
required: sms:false

PharyngealAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Anastomotic Leak
required: sms:false

PharyngealFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Fistula
required: sms:false

PharyngealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Hemorrhage
required: sms:false

PharyngealMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Mucositis
required: sms:false

PharyngealNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Necrosis
required: sms:false

PharyngealStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngeal Stenosis
required: sms:false

Pharyngitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngitis
required: sms:false

PharyngolaryngealPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pharyngolaryngeal Pain
required: sms:false

Phlebitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Phlebitis
required: sms:false

PhlebitisInfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Phlebitis Infective
required: sms:false

Photophobia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Photophobia
required: sms:false

Photosensitivity
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Photosensitivity
required: sms:false

PlateletCountDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Platelet Count Decreased
required: sms:false

PleuralEffusion
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pleural Effusion
required: sms:false

PleuralHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pleural Hemorrhage
required: sms:false

PleuralInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pleural Infection
required: sms:false

PleuriticPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pleuritic Pain
required: sms:false

Pneumonitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pneumonitis
required: sms:false

Pneumothorax
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pneumothorax
required: sms:false

PortalHypertension
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Portal Hypertension
required: sms:false

PortalVeinThrombosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Portal Vein Thrombosis
required: sms:false

PostnasalDrip
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Postnasal Drip
required: sms:false

PostoperativeHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Postoperative Hemorrhage
required: sms:false

PostoperativeThoracicProcedureComplication
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Postoperative Thoracic Procedure Complication
required: sms:false

PrecociousPuberty
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Precocious Puberty
required: sms:false

Pregnancy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pregnancy
required: sms:false

PuerperiumandPerinatalConditionsOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Puerperium and Perinatal Conditions Other
required: sms:false

PrematureDelivery
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Premature Delivery
required: sms:false

PrematureMenopause
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Premature Menopause
required: sms:false

Presyncope
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Presyncope
required: sms:false

Proctitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Proctitis
required: sms:false

ProductiveCough
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Productive Cough
required: sms:false

ProlapseofIntestinalStoma
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prolapse of Intestinal Stoma
required: sms:false

ProlapseofUrostomy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prolapse of Urostomy
required: sms:false

ProstateInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prostate Infection
required: sms:false

ProstaticHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prostatic Hemorrhage
required: sms:false

ProstaticObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prostatic Obstruction
required: sms:false

ProstaticPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Prostatic Pain
required: sms:false

Proteinuria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Proteinuria
required: sms:false

Pruritus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pruritus
required: sms:false

PsychiatricDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Psychiatric Disorders Other
required: sms:false

Psychosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Psychosis
required: sms:false

PulmonaryEdema
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pulmonary Edema
required: sms:false

PulmonaryFibrosis
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pulmonary Fibrosis
required: sms:false

PulmonaryFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pulmonary Fistula
required: sms:false

PulmonaryHypertension
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pulmonary Hypertension
required: sms:false

PulmonaryValveDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pulmonary Valve Disease
required: sms:false

Purpura
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Purpura
required: sms:false

PyramidalTractSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Pyramidal Tract Syndrome
required: sms:false

RadiationRecallReaction(Dermatologic)
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Radiation Recall Reaction (Dermatologic)
required: sms:false

Radiculitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Radiculitis
required: sms:false

RashAcneiform
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rash Acneiform
required: sms:false

RashMaculo-Papular
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rash Maculo-Papular
required: sms:false

RashPustular
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rash Pustular
required: sms:false

RectalAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Anastomotic Leak
required: sms:false

RectalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Fistula
required: sms:false

RectalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Hemorrhage
required: sms:false

RectalMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Mucositis
required: sms:false

RectalNecrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Necrosis
required: sms:false

RectalObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Obstruction
required: sms:false

RectalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Pain
required: sms:false

RectalPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Perforation
required: sms:false

RectalStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Stenosis
required: sms:false

RectalUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rectal Ulcer
required: sms:false

RecurrentLaryngealNervePalsy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Recurrent Laryngeal Nerve Palsy
required: sms:false

RenalandUrinaryDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Renal and Urinary Disorders Other
required: sms:false

RenalCalculi
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Renal Calculi
required: sms:false

RenalColic
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Renal Colic
required: sms:false

RenalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Renal Hemorrhage
required: sms:false

ReproductiveSystemandBreastDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Reproductive System and Breast Disorders Other
required: sms:false

RespiratoryFailure
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Respiratory Failure
required: sms:false

Respiratory
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Respiratory
required: sms:false

ThoracicandMediastinalDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Thoracic and Mediastinal Disorders Other
required: sms:false

Restlessness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Restlessness
required: sms:false

RestrictiveCardiomyopathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Restrictive Cardiomyopathy
required: sms:false

RetinalDetachment
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retinal Detachment
required: sms:false

RetinalTear
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retinal Tear
required: sms:false

RetinalVascularDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retinal Vascular Disorder
required: sms:false

RetinoicAcidSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retinoic Acid Syndrome
required: sms:false

Retinopathy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retinopathy
required: sms:false

RetroperitonealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Retroperitoneal Hemorrhage
required: sms:false

ReversiblePosteriorLeukoencephalopathySyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Reversible Posterior Leukoencephalopathy Syndrome
required: sms:false

RhinitisInfective
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Rhinitis Infective
required: sms:false

RightVentricularDysfunction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Right Ventricular Dysfunction
required: sms:false

SalivaryDuctInflammation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Salivary Duct Inflammation
required: sms:false

SalivaryGlandFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Salivary Gland Fistula
required: sms:false

SalivaryGlandInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Salivary Gland Infection
required: sms:false

ScalpPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Scalp Pain
required: sms:false

ScleralDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Scleral Disorder
required: sms:false

Scoliosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Scoliosis
required: sms:false

ScrotalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Scrotal Infection
required: sms:false

ScrotalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Scrotal Pain
required: sms:false

Seizure
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Seizure
required: sms:false

Sepsis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sepsis
required: sms:false

Seroma
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Seroma
required: sms:false

SerumAmylaseIncreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Serum Amylase Increased
required: sms:false

SerumSickness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Serum Sickness
required: sms:false

SickSinusSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sick Sinus Syndrome
required: sms:false

SinusBradycardia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sinus Bradycardia
required: sms:false

SinusDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sinus Disorder
required: sms:false

SinusPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sinus Pain
required: sms:false

SinusTachycardia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sinus Tachycardia
required: sms:false

Sinusitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sinusitis
required: sms:false

SkinandSubcutaneousTissueDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin and Subcutaneous Tissue Disorders Other
required: sms:false

SkinAtrophy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Atrophy
required: sms:false

SkinHyperpigmentation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Hyperpigmentation
required: sms:false

SkinHypopigmentation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Hypopigmentation
required: sms:false

SkinInduration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Induration
required: sms:false

SkinInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Infection
required: sms:false

SkinUlceration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Skin Ulceration
required: sms:false

SleepApnea
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sleep Apnea
required: sms:false

SmallIntestinalAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestinal Anastomotic Leak
required: sms:false

SmallIntestinalMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestinal Mucositis
required: sms:false

SmallIntestinalObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestinal Obstruction
required: sms:false

SmallIntestinalPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestinal Perforation
required: sms:false

SmallIntestinalStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestinal Stenosis
required: sms:false

SmallIntestineInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestine Infection
required: sms:false

SmallIntestineUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Small Intestine Ulcer
required: sms:false

Sneezing
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sneezing
required: sms:false

SocialCircumstancesOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Social Circumstances Other
required: sms:false

SoftTissueInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Soft Tissue Infection
required: sms:false

SoftTissueNecrosisLowerLimb
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Soft Tissue Necrosis Lower Limb
required: sms:false

SoftTissueNecrosisUpperLimb
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Soft Tissue Necrosis Upper Limb
required: sms:false

Somnolence
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Somnolence
required: sms:false

SoreThroat
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sore Throat
required: sms:false

Spasticity
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spasticity
required: sms:false

SpermaticCordAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spermatic Cord Anastomotic Leak
required: sms:false

SpermaticCordHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spermatic Cord Hemorrhage
required: sms:false

SpermaticCordObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spermatic Cord Obstruction
required: sms:false

SpinalFracture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spinal Fracture
required: sms:false

SpleenDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Spleen Disorder
required: sms:false

SplenicInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Splenic Infection
required: sms:false

StenosisofGastrointestinalStoma
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stenosis of Gastrointestinal Stoma
required: sms:false

Stevens-JohnsonSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stevens-Johnson Syndrome
required: sms:false

StomaSiteInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stoma Site Infection
required: sms:false

StomachPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stomach Pain
required: sms:false

StomalUlcer
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stomal Ulcer
required: sms:false

Stridor
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stridor
required: sms:false

Stroke
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Stroke
required: sms:false

SuddenDeathNOS
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Sudden Death NOS
required: sms:false

SuicidalIdeation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Suicidal Ideation
required: sms:false

SuicideAttempt
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Suicide Attempt
required: sms:false

SuperficialSoftTissueFibrosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Superficial Soft Tissue Fibrosis
required: sms:false

SuperficialThrombophlebitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Superficial Thrombophlebitis
required: sms:false

SuperiorVenaCavaSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Superior Vena Cava Syndrome
required: sms:false

SupraventricularTachycardia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Supraventricular Tachycardia
required: sms:false

SurgicalandMedicalProceduresOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Surgical and Medical Procedures Other
required: sms:false

Syncope
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Syncope
required: sms:false

Telangiectasia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Telangiectasia
required: sms:false

TesticularDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Testicular Disorder
required: sms:false

TesticularHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Testicular Hemorrhage
required: sms:false

TesticularPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Testicular Pain
required: sms:false

ThromboembolicEvent
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Thromboembolic Event
required: sms:false

ThromboticThrombocytopenicPurpura
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Thrombotic Thrombocytopenic Purpura
required: sms:false

Tinnitus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tinnitus
required: sms:false

ToothDevelopmentDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tooth Development Disorder
required: sms:false

ToothDiscoloration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tooth Discoloration
required: sms:false

ToothInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tooth Infection
required: sms:false

Toothache
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Toothache
required: sms:false

ToxicEpidermalNecrolysis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Toxic Epidermal Necrolysis
required: sms:false

TrachealFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheal Fistula
required: sms:false

TrachealHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheal Hemorrhage
required: sms:false

TrachealMucositis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheal Mucositis
required: sms:false

TrachealObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheal Obstruction
required: sms:false

TrachealStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheal Stenosis
required: sms:false

Tracheitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheitis
required: sms:false

TracheostomySiteBleeding
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tracheostomy Site Bleeding
required: sms:false

TransientIschemicAttacks
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Transient Ischemic Attacks
required: sms:false

TreatmentRelatedSecondaryMalignancy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Treatment Related Secondary Malignancy
required: sms:false

Tremor
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tremor
required: sms:false

TricuspidValveDisease
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tricuspid Valve Disease
required: sms:false

TrigeminalNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Trigeminal Nerve Disorder
required: sms:false

Trismus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Trismus
required: sms:false

TumorLysisSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tumor Lysis Syndrome
required: sms:false

TumorPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Tumor Pain
required: sms:false

Typhlitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Typhlitis
required: sms:false

UnequalLimbLength
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Unequal Limb Length
required: sms:false

UnintendedPregnancy
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Unintended Pregnancy
required: sms:false

UpperGastrointestinalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Upper Gastrointestinal Hemorrhage
required: sms:false

UpperRespiratoryInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Upper Respiratory Infection
required: sms:false

UretericAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ureteric Anastomotic Leak
required: sms:false

UrethralAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urethral Anastomotic Leak
required: sms:false

UrethralInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urethral Infection
required: sms:false

UrinaryFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Fistula
required: sms:false

UrinaryFrequency
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Frequency
required: sms:false

UrinaryIncontinence
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Incontinence
required: sms:false

UrinaryRetention
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Retention
required: sms:false

UrinaryTractInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Tract Infection
required: sms:false

UrinaryTractObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Tract Obstruction
required: sms:false

UrinaryTractPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Tract Pain
required: sms:false

UrinaryUrgency
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urinary Urgency
required: sms:false

UrineDiscoloration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urine Discoloration
required: sms:false

UrineOutputDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urine Output Decreased
required: sms:false

UrostomyLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urostomy Leak
required: sms:false

UrostomyObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urostomy Obstruction
required: sms:false

UrostomySiteBleeding
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urostomy Site Bleeding
required: sms:false

UrostomyStenosis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urostomy Stenosis
required: sms:false

Urticaria
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Urticaria
required: sms:false

UterineAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Anastomotic Leak
required: sms:false

UterineFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Fistula
required: sms:false

UterineHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Hemorrhage
required: sms:false

UterineInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Infection
required: sms:false

UterineObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Obstruction
required: sms:false

UterinePain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Pain
required: sms:false

UterinePerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uterine Perforation
required: sms:false

Uveitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Uveitis
required: sms:false

VaginalAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Anastomotic Leak
required: sms:false

VaginalDischarge
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Discharge
required: sms:false

VaginalDryness
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Dryness
required: sms:false

VaginalFistula
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Fistula
required: sms:false

VaginalHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Hemorrhage
required: sms:false

VaginalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Infection
required: sms:false

VaginalInflammation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Inflammation
required: sms:false

VaginalObstruction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Obstruction
required: sms:false

VaginalPain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Pain
required: sms:false

VaginalPerforation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Perforation
required: sms:false

VaginalStricture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginal Stricture
required: sms:false

Vaginismus
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vaginismus
required: sms:false

VagusNerveDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vagus Nerve Disorder
required: sms:false

VasDeferensAnastomoticLeak
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vas Deferens Anastomotic Leak
required: sms:false

VascularAccessComplication
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vascular Access Complication
required: sms:false

VascularDisordersOther
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vascular Disorders Other
required: sms:false

Vasculitis
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vasculitis
required: sms:false

VasovagalReaction
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vasovagal Reaction
required: sms:false

VenousInjury
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Venous Injury
required: sms:false

VentricularArrhythmia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ventricular Arrhythmia
required: sms:false

VentricularFibrillation
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ventricular Fibrillation
required: sms:false

VentricularTachycardia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Ventricular Tachycardia
required: sms:false

Vertigo
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vertigo
required: sms:false

VestibularDisorder
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vestibular Disorder
required: sms:false

Virilization
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Virilization
required: sms:false

VisceralArterialIschemia
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Visceral Arterial Ischemia
required: sms:false

VitalCapacityAbnormal
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vital Capacity Abnormal
required: sms:false

VitreousHemorrhage
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vitreous Hemorrhage
required: sms:false

VoiceAlteration
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Voice Alteration
required: sms:false

Vomiting
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vomiting
required: sms:false

VulvalInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Vulval Infection
required: sms:false

WateringEyes
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Watering Eyes
required: sms:false

WeightGain
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Weight Gain
required: sms:false

WeightLoss
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Weight Loss
required: sms:false

Wheezing
type: Class
comment: TBD
subclass of: CurrentLungCancerSymptoms
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: wheezing
required: sms:false

WhiteBloodCellDecreased
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: White Blood Cell Decreased
required: sms:false

Wolff-Parkinson-WhiteSyndrome
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Wolff-Parkinson-White Syndrome
required: sms:false

WoundComplication
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Wound Complication
required: sms:false

WoundDehiscence
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Wound Dehiscence
required: sms:false

WoundInfection
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Wound Infection
required: sms:false

WristFracture
type: Class
comment: TBD
subclass of: AdverseEvent
is part of: schema.biothings.io
display name: Wrist Fracture
required: sms:false

AcuteRenalFailure
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Acute Renal Failure
required: sms:false

Adenocarcinoma
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Adenocarcinoma
required: sms:false

AdrenocorticalInsufficiency
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Adrenocortical Insufficiency
required: sms:false

AdenomatousPolyposisColi
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Adenomatous Polyposis Coli
required: sms:false

Allergies
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Allergies
required: sms:false

Alpha-1Antitrypsin
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Alpha-1 Antitrypsin
required: sms:false

Arrhythmia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Arrhythmia
required: sms:false

Asthma
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Asthma
required: sms:false

Barrett'sEsophagus
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Barrett's Esophagus
required: sms:false

BasalCellCarcinoma
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Basal Cell Carcinoma
required: sms:false

Beckwith-Wiedemann
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
subclass of: Comorbidity
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Beckwith-Wiedemann
required: sms:false

Behcet'sDisease
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Behcet's Disease
required: sms:false

BiliaryDisorder
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Biliary Disorder
required: sms:false

BloodClots
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Blood Clots
required: sms:false

BoneFracture(s)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Bone Fracture(s)
required: sms:false

Bronchitis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Bronchitis
required: sms:false

CalciumChannelBlockers
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Calcium Channel Blockers
required: sms:false

Cataracts
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Cataracts
required: sms:false

CeliacDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Celiac Disease
required: sms:false

Cirrhosis
type: Class
comment: TBD
subclass of: Comorbidity
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Cirrhosis
required: sms:false

UnknownEtiology
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: unknown Etiology
required: sms:false

CerebrovascularDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Cerebrovascular Disease
required: sms:false

Cholelithiasis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Cholelithiasis
required: sms:false

ChronicRenalFailure
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Chronic Renal Failure
required: sms:false

ColonPolyps
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Colon Polyps
required: sms:false

CommonVariableImmunodeficiency
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Common Variable Immunodeficiency
required: sms:false

CongestiveHeartFailure(CHF)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Congestive Heart Failure (CHF)
required: sms:false

ConnectiveTissueDisorder
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Connective Tissue Disorder
required: sms:false

COPD
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: COPD
required: sms:false

CoronaryArteryDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Coronary Artery Disease
required: sms:false

Crohn'sDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Crohn's Disease
required: sms:false

CryptogenicOrganizingPneumonia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Cryptogenic Organizing Pneumonia
required: sms:false

DeepVeinThrombosis/Thromboembolism
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Deep Vein Thrombosis / Thromboembolism
required: sms:false

Denys-DrashSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Denys-Drash Syndrome
required: sms:false

Diabetes
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Diabetes
required: sms:false

TypeII
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Type II
required: sms:false

DiabeticNeuropathy
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Diabetic Neuropathy
required: sms:false

DietControlledDiabetes
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Diet Controlled Diabetes
required: sms:false

Diverticulitis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Diverticulitis
required: sms:false

DVT/PE
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: DVT/PE
required: sms:false

Dyslipidemia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Dyslipidemia
required: sms:false

Epilepsy
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Epilepsy
required: sms:false

Eczema
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Eczema
required: sms:false

Epstein-BarrVirus
type: Class
comment: TBD
subclass of: LaboratoryTest
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Epstein-Barr Virus
required: sms:false

FamilialAdenomatousPolyposis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Familial Adenomatous Polyposis
required: sms:false

FanconiAnemia
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Fanconi Anemia
required: sms:false

Fibrosis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Fibrosis
required: sms:false

GERD
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: GERD
required: sms:false

GlycogenStorageDisease
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Glycogen Storage Disease
required: sms:false

Gout
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Gout
required: sms:false

GonadalDysfunction
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Gonadal Dysfunction
required: sms:false

GorlinSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Gorlin Syndrome
required: sms:false

H.pyloriInfection
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: H. pylori Infection
required: sms:false

Hashimoto'sThyroiditis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hashimoto's Thyroiditis
required: sms:false

HeartDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Heart Disease
required: sms:false

Hemihypertrophy
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hemihypertrophy
required: sms:false

HemorrhagicCystitis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hemorrhagic Cystitis
required: sms:false

Hepatitis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hepatitis
required: sms:false

HepatitisAInfection
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hepatitis A Infection
required: sms:false

HepatitisBInfection
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hepatitis B Infection
required: sms:false

HepatitisCInfection
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hepatitis C Infection
required: sms:false

ChronicHepatitis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Chronic Hepatitis
required: sms:false

HereditaryNon-polyposisColonCancer
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hereditary Non-polyposis Colon Cancer
required: sms:false

Herpes
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Herpes
required: sms:false

HighGradeLiverDysplasticNodule
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: High Grade Liver Dysplastic Nodule
required: sms:false

HIV/AIDS
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: HIV / AIDS
required: sms:false

HumanPapillomavirusInfection
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Human Papillomavirus Infection
required: sms:false

HUS/TTP
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: HUS/TTP
required: sms:false

Hypercholesterolemia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hypercholesterolemia
required: sms:false

Hyperlipidemia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hyperlipidemia
required: sms:false

Hypospadias
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Hypospadias
required: sms:false

InflammatoryBowelDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Inflammatory Bowel Disease
required: sms:false

InsulinControlledDiabetes
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Insulin Controlled Diabetes
required: sms:false

InterstitialPneumontisorARDS
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Interstitial Pneumontis or ARDS
required: sms:false

IntraductalPapillaryMucinousNeoplasm
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Intraductal Papillary Mucinous Neoplasm
required: sms:false

IschemicHeartDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Ischemic Heart Disease
required: sms:false

ITP
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: ITP
required: sms:false

JointReplacement
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Joint Replacement
required: sms:false

KidneyDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Kidney Disease
required: sms:false

LiverCirrhosis(LiverDisease)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Liver Cirrhosis (Liver Disease)
required: sms:false

LiverToxicity(Non-Infectious)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Liver Toxicity (Non-Infectious)
required: sms:false

Li-FraumeniSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Li-Fraumeni Syndrome
required: sms:false

LowGradeLiverDysplasticNodule
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Low Grade Liver Dysplastic Nodule
required: sms:false

Lupus
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Lupus
required: sms:false

LynchSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Lynch Syndrome
required: sms:false

MAI
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: MAI
required: sms:false

MyastheniaGravis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Myasthenia Gravis
required: sms:false

NeuroendocrineTumor
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Neuroendocrine Tumor
required: sms:false

NonalcoholicSteatohepatitis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Nonalcoholic Steatohepatitis
required: sms:false

Organtransplant(site)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Organ transplant (site)
required: sms:false

Osteoarthritis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Osteoarthritis
required: sms:false

OsteoporosisorOsteopenia
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Osteoporosis or Osteopenia
required: sms:false

OtherCancerWithin5Years
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Other Cancer Within 5 Years
required: sms:false

OtherNonmalignantSystemicDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Other Nonmalignant Systemic Disease
required: sms:false

OtherPulmonaryComplications
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Other Pulmonary Complications
required: sms:false

Pain(Various)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Pain (Various)
required: sms:false

PepticUlcer(Ulcer)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Peptic Ulcer (Ulcer)
required: sms:false

PeripheralNeuropathy
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Peripheral Neuropathy
required: sms:false

PeripheralVascularDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Peripheral Vascular Disease
required: sms:false

Peutz-JeghersDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Peutz-Jeghers Disease
required: sms:false

PregnancyinPatientorPartner
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Pregnancy in Patient or Partner
required: sms:false

PrimarySclerosingCholangitis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Primary Sclerosing Cholangitis
required: sms:false

Psoriasis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Psoriasis
required: sms:false

PulmonaryHemorrhage
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Pulmonary Hemorrhage
required: sms:false

RenalFailure(RequiringDialysis)
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Renal Failure (Requiring Dialysis)
required: sms:false

RenalDialysis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Renal Dialysis
required: sms:false

RenalInsufficiency
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Renal Insufficiency
required: sms:false

RheumatologicDisease
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Rheumatologic Disease
required: sms:false

RheumatoidArthritis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Rheumatoid Arthritis
required: sms:false

Rubinstein-TaybiSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Rubinstein-Taybi Syndrome
required: sms:false

Sarcoidosis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Sarcoidosis
required: sms:false

Sleepapnea
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Sleep apnea
required: sms:false

Smoking
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Smoking
required: sms:false

Steatosis
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Steatosis
required: sms:false

TransientIschemicAttack
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Transient Ischemic Attack
required: sms:false

Tuberculosis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Tuberculosis
required: sms:false

TurcotSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Turcot Syndrome
required: sms:false

Tyrosinemia
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Tyrosinemia
required: sms:false

UlcerativeColitis
type: Class
comment: TBD
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Ulcerative Colitis
required: sms:false

WagrSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
subclass of: Comorbidity
is part of: schema.biothings.io
display name: Wagr Syndrome
required: sms:false

Histology
type: Class
comment: TBD
subclass of: ComorbidityMethodofDiagnosis
is part of: schema.biothings.io
display name: Histology
required: sms:false

Pathology
type: Class
comment: TBD
subclass of: ComorbidityMethodofDiagnosis
is part of: schema.biothings.io
display name: Pathology
required: sms:false

Radiology
type: Class
comment: TBD
subclass of: ComorbidityMethodofDiagnosis
is part of: schema.biothings.io
display name: Radiology
required: sms:false

DaystoProgression
type: Class
comment: Number of days between the date used for index and the date the patient's disease progressed. If not applicable please enter 'Not Applicable'
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Days to Progression
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

DaystoProgressionFree
type: Class
comment: Number of days between the date used for index and the date the patient's disease was formally confirmed as progression-free. If not applicable please enter 'Not Applicable'
subclass of: Diagnosis
is part of: schema.biothings.io
display name: Days to Progression Free
required: sms:false
validation rules: regex match \d+$|Not\sApplicable$|unknown$

Alpha-GlucosidaseInhibitor
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Alpha-Glucosidase Inhibitor
required: sms:false

Biguanide
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Biguanide
required: sms:false

Diet
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Diet
required: sms:false

InjectedInsulin
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Injected Insulin
required: sms:false

Insulin
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Insulin
required: sms:false

OralHypoglycemic
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Oral Hypoglycemic
required: sms:false

Sulfonylurea
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Sulfonylurea
required: sms:false

Thiazolidinedione
type: Class
comment: TBD
subclass of: DiabetesTreatmentType
is part of: schema.biothings.io
display name: Thiazolidinedione
required: sms:false

AJ-AdjuvantTherapy
type: Class
comment: TBD
subclass of: DiseaseResponse
subclass of: BestOverallResponse
is part of: schema.biothings.io
display name: AJ-Adjuvant Therapy
required: sms:false

BED-BiochemicalEvidenceofDisease
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: BED-Biochemical Evidence of Disease
required: sms:false

CPD-ClinicalProgression
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: CPD-Clinical Progression
required: sms:false

CR-CompleteResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: CR-Complete Response
required: sms:false

CRU-CompleteResponseUnconfirmed
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: CRU-Complete Response Unconfirmed
required: sms:false

DU-DiseaseUnchanged
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: DU-Disease Unchanged
required: sms:false

IMR-Immunoresponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: IMR-Immunoresponse
required: sms:false

IPD-Immunoprogression
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: IPD-Immunoprogression
required: sms:false

MR-Minimal/Marginalresponse
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: MR-Minimal/Marginal response
required: sms:false

MX-MixedResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: MX-Mixed Response
required: sms:false

Non-CR/Non-PD-Non-CR/Non-PD
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: Non-CR/Non-PD-Non-CR/Non-PD
required: sms:false

NPB-NoPalliativeBenefit
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: NPB-No Palliative Benefit
required: sms:false

NR-NoResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: NR-No Response
required: sms:false

PA-PalliativeTherapy
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PA-Palliative Therapy
required: sms:false

PB-PalliativeBenefit
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PB-Palliative Benefit
required: sms:false

PD-ProgressiveDisease
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PD-Progressive Disease
required: sms:false

PDM-PersistentDistantMetastasis
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PDM-Persistent Distant Metastasis
required: sms:false

PLD-PersistentLocoregionalDisease
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PLD-Persistent Locoregional Disease
required: sms:false

PPD-Pseudoprogression
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PPD-Pseudoprogression
required: sms:false

PR-PartialResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PR-Partial Response
required: sms:false

PSR-Pseudoresponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: PSR-Pseudoresponse
required: sms:false

RD-ResponsiveDisease
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: RD-Responsive Disease
required: sms:false

RP-Response
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: RP-Response
required: sms:false

RPD-RadiographicProgressiveDisease
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: RPD-Radiographic Progressive Disease
required: sms:false

SCR-StringentCompleteResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: sCR-Stringent Complete Response
required: sms:false

SD-StableDisease
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: SD-Stable Disease
required: sms:false

SPD-SurgicalProgression
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: SPD-Surgical Progression
required: sms:false

TE-TooEarly
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: TE-Too Early
required: sms:false

TF-TumorFree
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: TF-Tumor Free
required: sms:false

VGPR-VeryGoodPartialResponse
type: Class
comment: TBD
subclass of: BestOverallResponse
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: VGPR-Very Good Partial Response
required: sms:false

WT-WithTumor
type: Class
comment: TBD
subclass of: DiseaseResponse
is part of: schema.biothings.io
display name: WT-With Tumor
required: sms:false

"0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "0"
required: sms:false

"1"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "1"
required: sms:false

"2"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "2"
required: sms:false

"3"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "3"
required: sms:false

"4"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "4"
required: sms:false

"5"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "5"
required: sms:false

"0.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "0.0"
required: sms:false

"1.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "1.0"
required: sms:false

"2.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "2.0"
required: sms:false

"3.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "3.0"
required: sms:false

"4.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "4.0"
required: sms:false

"5.0"
type: Class
comment: TBD
subclass of: ECOGPerformanceStatus
is part of: schema.biothings.io
display name: "5.0"
required: sms:false

"16"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "16"
required: sms:false

"18"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "18"
required: sms:false

"26"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "26"
required: sms:false

"31"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "31"
required: sms:false

"33"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "33"
required: sms:false

"35"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "35"
required: sms:false

"39"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "39"
required: sms:false

"45"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "45"
required: sms:false

"51"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "51"
required: sms:false

"52"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "52"
required: sms:false

"53"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "53"
required: sms:false

"56"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "56"
required: sms:false

"58"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "58"
required: sms:false

"59"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "59"
required: sms:false

"63"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "63"
required: sms:false

"66"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "66"
required: sms:false

"68"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "68"
required: sms:false

"70"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "70"
required: sms:false

"73"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "73"
required: sms:false

"82"
type: Class
comment: TBD
subclass of: HPVPositiveType
is part of: schema.biothings.io
display name: "82"
required: sms:false

"10"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "10"
required: sms:false

"20"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "20"
required: sms:false

"30"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "30"
required: sms:false

"40"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "40"
required: sms:false

"50"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "50"
required: sms:false

"60"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "60"
required: sms:false

"80"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "80"
required: sms:false

"90"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "90"
required: sms:false

"100"
type: Class
comment: TBD
subclass of: KarnofskyPerformanceStatus
is part of: schema.biothings.io
display name: "100"
required: sms:false

Premenopausal
type: Class
comment: TBD
subclass of: MenopauseStatus
is part of: schema.biothings.io
display name: Premenopausal
required: sms:false

Perimenopausal
type: Class
comment: TBD
subclass of: MenopauseStatus
is part of: schema.biothings.io
display name: Perimenopausal
required: sms:false

Postmenopausal
type: Class
comment: TBD
subclass of: MenopauseStatus
is part of: schema.biothings.io
display name: Postmenopausal
required: sms:false

Grade1
type: Class
comment: TBD
subclass of: AdverseEventGrade
is part of: schema.biothings.io
display name: Grade 1
required: sms:false

Grade2
type: Class
comment: TBD
subclass of: AdverseEventGrade
is part of: schema.biothings.io
display name: Grade 2
required: sms:false

Grade3
type: Class
comment: TBD
subclass of: AdverseEventGrade
is part of: schema.biothings.io
display name: Grade 3
required: sms:false

Grade4
type: Class
comment: TBD
subclass of: AdverseEventGrade
is part of: schema.biothings.io
display name: Grade 4
required: sms:false

Grade5
type: Class
comment: TBD
subclass of: AdverseEventGrade
is part of: schema.biothings.io
display name: Grade 5
required: sms:false

Candidiasis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Candidiasis
required: sms:false

Coccidioidomycosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Coccidioidomycosis
required: sms:false

Cryptococcosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Cryptococcosis
required: sms:false

Cytomegalovirus
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Cytomegalovirus
required: sms:false

HerpesSimplexVirus
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Herpes Simplex Virus
required: sms:false

Histoplasmosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Histoplasmosis
required: sms:false

Isosporiasis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Isosporiasis
required: sms:false

MycobacteriumaviumComplex
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Mycobacterium avium Complex
required: sms:false

Mycobacteriumtuberculosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Mycobacterium tuberculosis
required: sms:false

Mycobacterium
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Mycobacterium
required: sms:false

NOS
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
subclass of: AIDSRiskFactors
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: NOS
required: sms:false

Nocardiosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Nocardiosis
required: sms:false

PneumocystisPneumonia
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Pneumocystis Pneumonia
required: sms:false

Pneumonia
type: Class
comment: TBD
subclass of: CurrentLungCancerSymptoms
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: pneumonia
required: sms:false

ProgressiveMultifocalLeukoencephalopathy
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Progressive Multifocal Leukoencephalopathy
required: sms:false

SalmonellaSepticemia
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Salmonella Septicemia
required: sms:false

Toxoplasmosis
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Toxoplasmosis
required: sms:false

WastingSyndrome
type: Class
comment: TBD
subclass of: AIDSRiskFactors
is part of: schema.biothings.io
display name: Wasting Syndrome
required: sms:false

Hemophiliac
type: Class
comment: TBD
subclass of: CDCHIVRiskFactors
is part of: schema.biothings.io
display name: Hemophiliac
required: sms:false

HeterosexualContact
type: Class
comment: TBD
subclass of: CDCHIVRiskFactors
is part of: schema.biothings.io
display name: Heterosexual Contact
required: sms:false

HomosexualContact
type: Class
comment: TBD
subclass of: CDCHIVRiskFactors
is part of: schema.biothings.io
display name: Homosexual Contact
required: sms:false

IntravenousDrugUser
type: Class
comment: TBD
subclass of: CDCHIVRiskFactors
is part of: schema.biothings.io
display name: Intravenous Drug User
required: sms:false

TransfusionRecipient
type: Class
comment: TBD
subclass of: CDCHIVRiskFactors
is part of: schema.biothings.io
display name: Transfusion Recipient
required: sms:false

BiopsywithHistologicConfirmation
type: Class
comment: TBD
subclass of: EvidenceofRecurrenceType
is part of: schema.biothings.io
display name: Biopsy with Histologic Confirmation
required: sms:false

ConvincingImageSource
type: Class
comment: TBD
subclass of: EvidenceofRecurrenceType
is part of: schema.biothings.io
display name: Convincing Image Source
required: sms:false

PositiveBiomarkers
type: Class
comment: TBD
subclass of: EvidenceofRecurrenceType
is part of: schema.biothings.io
display name: Positive Biomarkers
required: sms:false

CurrentUser
type: Class
comment: TBD
subclass of: HormonalContraceptiveUse
is part of: schema.biothings.io
display name: Current User
required: sms:false

FormerUser
type: Class
comment: TBD
subclass of: HormonalContraceptiveUse
is part of: schema.biothings.io
display name: Former User
required: sms:false

NeverUsed
type: Class
comment: TBD
subclass of: HormonalContraceptiveUse
is part of: schema.biothings.io
display name: Never Used
required: sms:false

Bladder
type: Class
comment: TBD
subclass of: HysterectomyMarginsInvolved
subclass of: NCIAtlasCancerSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bladder
required: sms:false

MacroscopicParametrium
type: Class
comment: TBD
subclass of: HysterectomyMarginsInvolved
is part of: schema.biothings.io
display name: Macroscopic Parametrium
required: sms:false

MicroscopicParametrium
type: Class
comment: TBD
subclass of: HysterectomyMarginsInvolved
is part of: schema.biothings.io
display name: Microscopic Parametrium
required: sms:false

Vagina
type: Class
comment: TBD
subclass of: HysterectomyMarginsInvolved
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Vagina
required: sms:false

HysterectomyNOS
type: Class
comment: TBD
subclass of: HysterectomyType
is part of: schema.biothings.io
display name: Hysterectomy NOS
required: sms:false

Notperformed
type: Class
comment: TBD
subclass of: HysterectomyType
subclass of: BreastCancerGenomicTestPerformed
is part of: schema.biothings.io
display name: Not performed
required: sms:false

RadicalHysterectomy
type: Class
comment: TBD
subclass of: HysterectomyType
is part of: schema.biothings.io
display name: Radical Hysterectomy
required: sms:false

SimpleHysterectomy
type: Class
comment: TBD
subclass of: HysterectomyType
is part of: schema.biothings.io
display name: Simple Hysterectomy
required: sms:false

Positive
type: Class
comment: TBD
subclass of: ImagingResult
subclass of: BreastCarcinomaHER2Status
subclass of: CutaneousMelanomaSurgicalMargins
subclass of: Polarity
subclass of: BreastCarcinomaEstrogenReceptorStatus
subclass of: BreastCarcinomaProgesteronerReceptorStatus
subclass of: TestResult
is part of: schema.biothings.io
display name: positive
required: sms:false

Indeterminate
type: Class
comment: TBD
subclass of: ColorectalCancerTumorBorderConfiguration
subclass of: ImagingResult
subclass of: TumorExtranodalExtensionIndicator
subclass of: NonNodalRegionalDisease
subclass of: MLH1PromoterMethylationStatus
subclass of: OvarianSurfaceInvolvement
subclass of: BreastCarcinomaEstrogenReceptorStatus
subclass of: BreastCarcinomaProgesteronerReceptorStatus
subclass of: MRDALLDiagnosticSensitivity
subclass of: BreastCarcinomaHER2Status
is part of: schema.biothings.io
display name: Indeterminate
required: sms:false

Negative
type: Class
comment: TBD
subclass of: BreastCarcinomaHER2Status
subclass of: CutaneousMelanomaSurgicalMargins
subclass of: Polarity
subclass of: ImagingResult
subclass of: BreastCarcinomaEstrogenReceptorStatus
subclass of: BreastCarcinomaProgesteronerReceptorStatus
subclass of: TestResult
is part of: schema.biothings.io
display name: negative
required: sms:false

NotPerformed
type: Class
comment: TBD
subclass of: ImagingResult
subclass of: BreastCarcinomaEstrogenReceptorStatus
subclass of: BreastCarcinomaProgesteronerReceptorStatus
subclass of: BreastCarcinomaHER2Status
is part of: schema.biothings.io
display name: Not Performed
required: sms:false

99mTcBoneScintigraphy
type: Class
comment: TBD
subclass of: ImagingType
is part of: schema.biothings.io
display name: 99mTc Bone Scintigraphy
required: sms:false

CTScan
type: Class
comment: TBD
subclass of: ImagingType
is part of: schema.biothings.io
display name: CT Scan
required: sms:false

MRI
type: Class
comment: TBD
subclass of: ImagingType
subclass of: BreastImagingPerformedType
is part of: schema.biothings.io
display name: MRI
required: sms:false

PET
type: Class
comment: TBD
subclass of: ImagingType
is part of: schema.biothings.io
display name: PET
required: sms:false

Anti-TNFTherapy
type: Class
comment: TBD
subclass of: ImmunosuppressiveTreatmentType
is part of: schema.biothings.io
display name: Anti-TNFTherapy
required: sms:false

Azathioprine
type: Class
comment: TBD
subclass of: ImmunosuppressiveTreatmentType
is part of: schema.biothings.io
display name: Azathioprine
required: sms:false

Cyclophosphamide
type: Class
comment: TBD
subclass of: ImmunosuppressiveTreatmentType
is part of: schema.biothings.io
display name: Cyclophosphamide
required: sms:false

Methotrexate
type: Class
comment: TBD
subclass of: ImmunosuppressiveTreatmentType
is part of: schema.biothings.io
display name: Methotrexate
required: sms:false

EctopicPregnancy
type: Class
comment: TBD
subclass of: PregnancyOutcome
is part of: schema.biothings.io
display name: Ectopic Pregnancy
required: sms:false

InducedAbortion
type: Class
comment: TBD
subclass of: PregnancyOutcome
is part of: schema.biothings.io
display name: Induced Abortion
required: sms:false

LiveBirth
type: Class
comment: TBD
subclass of: PregnancyOutcome
is part of: schema.biothings.io
display name: Live Birth
required: sms:false

Miscarriage
type: Class
comment: TBD
subclass of: PregnancyOutcome
is part of: schema.biothings.io
display name: Miscarriage
required: sms:false

Stillbirth
type: Class
comment: TBD
subclass of: PregnancyOutcome
is part of: schema.biothings.io
display name: Stillbirth
required: sms:false

Acetate
type: Class
comment: TBD
subclass of: ScanTracerUsed
is part of: schema.biothings.io
display name: Acetate
required: sms:false

Axumin
type: Class
comment: TBD
subclass of: ScanTracerUsed
is part of: schema.biothings.io
display name: Axumin
required: sms:false

Choline
type: Class
comment: TBD
subclass of: ScanTracerUsed
is part of: schema.biothings.io
display name: Choline
required: sms:false

PSMA
type: Class
comment: TBD
subclass of: ScanTracerUsed
is part of: schema.biothings.io
display name: PSMA
required: sms:false

SodiumFluoride
type: Class
comment: TBD
subclass of: ScanTracerUsed
is part of: schema.biothings.io
display name: Sodium Fluoride
required: sms:false

Yes-ProgressionorRecurrence
type: Class
comment: The patient has had a new tumor event after initial treatment
subclass of: Diagnosis
subclass of: ProgressionorRecurrence
is part of: schema.biothings.io
display name: Yes - Progression or Recurrence
required: sms:false
requires dependency: ProgressionorRecurrenceType
requires dependency: DaystoProgression
requires dependency: DaystoProgressionFree
requires dependency: DaystoRecurrence
requires dependency: ProgressionorRecurrenceAnatomicSite

ProgressionorRecurrenceType
type: Class
comment: The text term used to describe the type of progressive or recurrent disease or relapsed disease.
subclass of: Diagnosis
is part of: schema.biothings.io
range includes: Biochemical
range includes: Distant
range includes: Local
range includes: Regional
range includes: Unknown
range includes: NotReported
display name: Progression or Recurrence Type
required: sms:false

ProgressionorRecurrenceAnatomicSite
type: Class
comment: The text term used to describe the anatomic site of resection; biopsy; tissue or organ of biospecimen origin; progression or recurrent disease; treatment
subclass of: FollowUp
is part of: schema.biothings.io
range includes: AbdomenNOS
range includes: Abdominalesophagus
range includes: AccessorysinusNOS
range includes: Acousticnerve
range includes: AdrenalglandNOS
range includes: AmpullaofVater
range includes: Analcanal
range includes: Anterior2/3oftongueNOS
range includes: Anteriorfloorofmouth
range includes: Anteriormediastinum
range includes: Anteriorsurfaceofepiglottis
range includes: Anteriorwallofbladder
range includes: Anteriorwallofnasopharynx
range includes: AnusNOS
range includes: Aorticbodyandotherparaganglia
range includes: Appendix
range includes: Ascendingcolon
range includes: AutonomicnervoussystemNOS
range includes: Axillarytailofbreast
range includes: BaseoftongueNOS
range includes: Bladderneck
range includes: BladderNOS
range includes: Blood
range includes: Bodyofpancreas
range includes: Bodyofpenis
range includes: Bodyofstomach
range includes: Bonemarrow
range includes: BoneoflimbNOS
range includes: BoneNOS
range includes: Bonesofskullandfaceandassociatedjoints
range includes: Borderoftongue
range includes: Brainstem
range includes: BrainNOS
range includes: Branchialcleft
range includes: BreastNOS
range includes: Broadligament
range includes: CardiaNOS
range includes: Carotidbody
range includes: Caudaequina
range includes: Cecum
range includes: Centralportionofbreast
range includes: CerebellumNOS
range includes: Cerebralmeninges
range includes: Cerebrum
range includes: Cervicalesophagus
range includes: Cervixuteri
range includes: Choroid
range includes: Ciliarybody
range includes: Cloacogeniczone
range includes: ColonNOS
range includes: Commissureoflip
range includes: Conjunctiva
range includes: Connectivesubcutaneousandothersofttissuesofabdomen
range includes: Connectivesubcutaneousandothersofttissuesofheadfaceandneck
range includes: Connectivesubcutaneousandothersofttissuesoflowerlimbandhip
range includes: Connectivesubcutaneousandothersofttissuesofpelvis
range includes: Connectivesubcutaneousandothersofttissuesofthorax
range includes: ConnectivesubcutaneousandothersofttissuesoftrunkNOS
range includes: Connectivesubcutaneousandothersofttissuesofupperlimbandshoulder
range includes: ConnectivesubcutaneousandothersofttissuesNOS
range includes: CorneaNOS
range includes: Corpusuteri
range includes: Cortexofadrenalgland
range includes: CranialnerveNOS
range includes: Craniopharyngealduct
range includes: Descendedtestis
range includes: Descendingcolon
range includes: Domeofbladder
range includes: DorsalsurfaceoftongueNOS
range includes: Duodenum
range includes: Endocervix
range includes: EndocrineglandNOS
range includes: Endometrium
range includes: Epididymis
range includes: EsophagusNOS

AbdomenNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Abdomen NOS
required: sms:false

Abdominalesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Abdominal esophagus
required: sms:false

AccessorysinusNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Accessory sinus NOS
required: sms:false

Acousticnerve
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Acoustic nerve
required: sms:false

AdrenalglandNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Adrenal gland NOS
required: sms:false

AmpullaofVater
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ampulla of Vater
required: sms:false

Analcanal
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anal canal
required: sms:false

Anterior2/3oftongueNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior 2/3 of tongue NOS
required: sms:false

Anteriorfloorofmouth
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior floor of mouth
required: sms:false

Anteriormediastinum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior mediastinum
required: sms:false

Anteriorsurfaceofepiglottis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior surface of epiglottis
required: sms:false

Anteriorwallofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior wall of bladder
required: sms:false

Anteriorwallofnasopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anterior wall of nasopharynx
required: sms:false

AnusNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Anus NOS
required: sms:false

Aorticbodyandotherparaganglia
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Aortic body and other paraganglia
required: sms:false

Appendix
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Appendix
required: sms:false

Ascendingcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ascending colon
required: sms:false

AutonomicnervoussystemNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Autonomic nervous system NOS
required: sms:false

Axillarytailofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Axillary tail of breast
required: sms:false

BaseoftongueNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Base of tongue NOS
required: sms:false

Bladderneck
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bladder neck
required: sms:false

BladderNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bladder NOS
required: sms:false

Blood
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Blood
required: sms:false

Bodyofpancreas
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Body of pancreas
required: sms:false

Bodyofpenis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Body of penis
required: sms:false

Bodyofstomach
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Body of stomach
required: sms:false

Bonemarrow
type: Class
comment: TBD
subclass of: GliomaSpecificMetastasisSites
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bone marrow
required: sms:false

BoneoflimbNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bone of limb NOS
required: sms:false

BoneNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bone NOS
required: sms:false

Bonesofskullandfaceandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Bones of skull and face and associated joints
required: sms:false

Borderoftongue
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Border of tongue
required: sms:false

Brainstem
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Brain stem
required: sms:false

BrainNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Brain NOS
required: sms:false

Branchialcleft
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Branchial cleft
required: sms:false

BreastNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Breast NOS
required: sms:false

Broadligament
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Broad ligament
required: sms:false

CardiaNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cardia NOS
required: sms:false

Carotidbody
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Carotid body
required: sms:false

Caudaequina
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cauda equina
required: sms:false

Cecum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cecum
required: sms:false

Centralportionofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Central portion of breast
required: sms:false

CerebellumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cerebellum NOS
required: sms:false

Cerebralmeninges
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cerebral meninges
required: sms:false

Cerebrum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cerebrum
required: sms:false

Cervicalesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cervical esophagus
required: sms:false

Cervixuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cervix uteri
required: sms:false

Choroid
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Choroid
required: sms:false

Ciliarybody
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ciliary body
required: sms:false

Cloacogeniczone
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cloacogenic zone
required: sms:false

ColonNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Colon NOS
required: sms:false

Commissureoflip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Commissure of lip
required: sms:false

Conjunctiva
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Conjunctiva
required: sms:false

Connectivesubcutaneousandothersofttissuesofabdomen
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of abdomen
required: sms:false

Connectivesubcutaneousandothersofttissuesofheadfaceandneck
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of head face and neck
required: sms:false

Connectivesubcutaneousandothersofttissuesoflowerlimbandhip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of lower limb and hip
required: sms:false

Connectivesubcutaneousandothersofttissuesofpelvis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of pelvis
required: sms:false

Connectivesubcutaneousandothersofttissuesofthorax
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of thorax
required: sms:false

ConnectivesubcutaneousandothersofttissuesoftrunkNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of trunk NOS
required: sms:false

Connectivesubcutaneousandothersofttissuesofupperlimbandshoulder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues of upper limb and shoulder
required: sms:false

ConnectivesubcutaneousandothersofttissuesNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Connective subcutaneous and other soft tissues NOS
required: sms:false

CorneaNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cornea NOS
required: sms:false

Corpusuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Corpus uteri
required: sms:false

Cortexofadrenalgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cortex of adrenal gland
required: sms:false

CranialnerveNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cranial nerve NOS
required: sms:false

Craniopharyngealduct
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Craniopharyngeal duct
required: sms:false

Descendedtestis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Descended testis
required: sms:false

Descendingcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Descending colon
required: sms:false

Domeofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Dome of bladder
required: sms:false

DorsalsurfaceoftongueNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Dorsal surface of tongue NOS
required: sms:false

Duodenum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Duodenum
required: sms:false

Endocervix
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Endocervix
required: sms:false

EndocrineglandNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Endocrine gland NOS
required: sms:false

Endometrium
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Endometrium
required: sms:false

Epididymis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Epididymis
required: sms:false

EsophagusNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Esophagus NOS
required: sms:false

Ethmoidsinus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ethmoid sinus
required: sms:false

Exocervix
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Exocervix
required: sms:false

Externalear
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: External ear
required: sms:false

ExternallipNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: External lip NOS
required: sms:false

Externallowerlip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: External lower lip
required: sms:false

Externalupperlip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: External upper lip
required: sms:false

Extrahepaticbileduct
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Extrahepatic bile duct
required: sms:false

EyeNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Eye NOS
required: sms:false

Eyelid
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Eyelid
required: sms:false

Fallopiantube
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Fallopian tube
required: sms:false

FemalegenitaltractNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Female genital tract NOS
required: sms:false

FloorofmouthNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Floor of mouth NOS
required: sms:false

Frontallobe
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Frontal lobe
required: sms:false

Frontalsinus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Frontal sinus
required: sms:false

Fundusofstomach
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Fundus of stomach
required: sms:false

Fundusuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Fundus uteri
required: sms:false

Gallbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Gallbladder
required: sms:false

Gastricantrum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Gastric antrum
required: sms:false

GastrointestinaltractNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Gastrointestinal tract NOS
required: sms:false

Glanspenis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Glans penis
required: sms:false

Glottis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Glottis
required: sms:false

GreatercurvatureofstomachNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Greater curvature of stomach NOS
required: sms:false

GumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Gum NOS
required: sms:false

Hardpalate
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Hard palate
required: sms:false

Headofpancreas
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Head of pancreas
required: sms:false

HeadfaceorneckNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Head face or neck NOS
required: sms:false

Heart
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Heart
required: sms:false

HematopoieticsystemNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Hematopoietic system NOS
required: sms:false

Hepaticflexureofcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Hepatic flexure of colon
required: sms:false

Hypopharyngealaspectofaryepiglotticfold
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Hypopharyngeal aspect of aryepiglottic fold
required: sms:false

HypopharynxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Hypopharynx NOS
required: sms:false

Ileum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ileum
required: sms:false

Ill-definedsiteswithinrespiratorysystem
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ill-defined sites within respiratory system
required: sms:false

IntestinaltractNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Intestinal tract NOS
required: sms:false

Intra-abdominallymphnodes
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Intra-abdominal lymph nodes
required: sms:false

Intrahepaticbileduct
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Intrahepatic bile duct
required: sms:false

Intrathoraciclymphnodes
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Intrathoracic lymph nodes
required: sms:false

IsletsofLangerhans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Islets of Langerhans
required: sms:false

Isthmusuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Isthmus uteri
required: sms:false

Jejunum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Jejunum
required: sms:false

KidneyNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Kidney NOS
required: sms:false

Labiummajus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Labium majus
required: sms:false

Labiumminus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Labium minus
required: sms:false

Lacrimalgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lacrimal gland
required: sms:false

Laryngealcartilage
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Laryngeal cartilage
required: sms:false

LarynxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Larynx NOS
required: sms:false

Lateralfloorofmouth
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lateral floor of mouth
required: sms:false

Lateralwallofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lateral wall of bladder
required: sms:false

Lateralwallofnasopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lateral wall of nasopharynx
required: sms:false

Lateralwalloforopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lateral wall of oropharynx
required: sms:false

LessercurvatureofstomachNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lesser curvature of stomach NOS
required: sms:false

Lingualtonsil
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lingual tonsil
required: sms:false

LipNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lip NOS
required: sms:false

Liver
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Liver
required: sms:false

Longbonesoflowerlimbandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Long bones of lower limb and associated joints
required: sms:false

Longbonesofupperlimbscapulaandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Long bones of upper limb scapula and associated joints
required: sms:false

Lowergum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower gum
required: sms:false

LowerlimbNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower limb NOS
required: sms:false

Lowerlobelung
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower lobe lung
required: sms:false

Lowerthirdofesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower third of esophagus
required: sms:false

Lower-innerquadrantofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower-inner quadrant of breast
required: sms:false

Lower-outerquadrantofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lower-outer quadrant of breast
required: sms:false

LungNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lung NOS
required: sms:false

LymphnodeNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lymph node NOS
required: sms:false

Lymphnodesofaxillaorarm
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lymph nodes of axilla or arm
required: sms:false

Lymphnodesofheadfaceandneck
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lymph nodes of head face and neck
required: sms:false

Lymphnodesofinguinalregionorleg
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lymph nodes of inguinal region or leg
required: sms:false

Lymphnodesofmultipleregions
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Lymph nodes of multiple regions
required: sms:false

Mainbronchus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Main bronchus
required: sms:false

MajorsalivaryglandNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Major salivary gland NOS
required: sms:false

MalegenitalorgansNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Male genital organs NOS
required: sms:false

Mandible
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mandible
required: sms:false

Maxillarysinus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Maxillary sinus
required: sms:false

Meckeldiverticulum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Meckel diverticulum
required: sms:false

MediastinumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Mediastinum NOS
required: sms:false

Medullaofadrenalgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Medulla of adrenal gland
required: sms:false

MeningesNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Meninges NOS
required: sms:false

Middleear
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Middle ear
required: sms:false

Middlelobelung
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Middle lobe lung
required: sms:false

Middlethirdofesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Middle third of esophagus
required: sms:false

MouthNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Mouth NOS
required: sms:false

MucosaoflipNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Mucosa of lip NOS
required: sms:false

Mucosaoflowerlip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Mucosa of lower lip
required: sms:false

Mucosaofupperlip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Mucosa of upper lip
required: sms:false

Myometrium
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Myometrium
required: sms:false

Nasalcavity
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Nasal cavity
required: sms:false

NasopharynxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Nasopharynx NOS
required: sms:false

NervoussystemNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Nervous system NOS
required: sms:false

Nipple
type: Class
comment: TBD
subclass of: BreastQuadrantSite
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Nipple
required: sms:false

Occipitallobe
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Occipital lobe
required: sms:false

Olfactorynerve
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Olfactory nerve
required: sms:false

Opticnerve
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Optic nerve
required: sms:false

OrbitNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Orbit NOS
required: sms:false

OropharynxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Oropharynx NOS
required: sms:false

Otherill-definedsites
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Other ill-defined sites
required: sms:false

Otherspecifiedpartsoffemalegenitalorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Other specified parts of female genital organs
required: sms:false

Otherspecifiedpartsofmalegenitalorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Other specified parts of male genital organs
required: sms:false

Otherspecifiedpartsofpancreas
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Other specified parts of pancreas
required: sms:false

Ovary
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: MetastasisatDiagnosisSite
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ovary
required: sms:false

Overlappinglesionofaccessorysinuses
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of accessory sinuses
required: sms:false

Overlappinglesionofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of bladder
required: sms:false

Overlappinglesionofbonesjointsandarticularcartilage
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of bones joints and articular cartilage
required: sms:false

Overlappinglesionofbonesjointsandarticularcartilageoflimbs
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of bones joints and articular cartilage of limbs
required: sms:false

Overlappinglesionofbrain
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of brain
required: sms:false

Overlappinglesionofbrainandcentralnervoussystem
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of brain and central nervous system
required: sms:false

Overlappinglesionofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of breast
required: sms:false

Overlappinglesionofcervixuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of cervix uteri
required: sms:false

Overlappinglesionofcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of colon
required: sms:false

Overlappinglesionofconnectivesubcutaneousandothersofttissues
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of connective subcutaneous and other soft tissues
required: sms:false

Overlappinglesionofcorpusuteri
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of corpus uteri
required: sms:false

Overlappinglesionofdigestivesystem
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of digestive system
required: sms:false

Overlappinglesionofendocrineglandsandrelatedstructures
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of endocrine glands and related structures
required: sms:false

Overlappinglesionofesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of esophagus
required: sms:false

Overlappinglesionofeyeandadnexa
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of eye and adnexa
required: sms:false

Overlappinglesionoffemalegenitalorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of female genital organs
required: sms:false

Overlappinglesionoffloorofmouth
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of floor of mouth
required: sms:false

Overlappinglesionofheartmediastinumandpleura
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of heart mediastinum and pleura
required: sms:false

Overlappinglesionofhypopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of hypopharynx
required: sms:false

Overlappinglesionofill-definedsites
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of ill-defined sites
required: sms:false

Overlappinglesionoflarynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of larynx
required: sms:false

Overlappinglesionoflip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of lip
required: sms:false

Overlappinglesionofliporalcavityandpharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of lip oral cavity and pharynx
required: sms:false

Overlappinglesionoflung
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of lung
required: sms:false

Overlappinglesionofmajorsalivaryglands
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of major salivary glands
required: sms:false

Overlappinglesionofmalegenitalorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of male genital organs
required: sms:false

Overlappinglesionofnasopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of nasopharynx
required: sms:false

Overlappinglesionofotherandunspecifiedpartsofmouth
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of other and unspecified parts of mouth
required: sms:false

Overlappinglesionofpalate
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of palate
required: sms:false

Overlappinglesionofpancreas
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of pancreas
required: sms:false

Overlappinglesionofpenis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of penis
required: sms:false

Overlappinglesionofperipheralnervesandautonomicnervoussystem
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of peripheral nerves and autonomic nervous system
required: sms:false

Overlappinglesionofrectumanusandanalcanal
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of rectum anus and anal canal
required: sms:false

Overlappinglesionofrespiratorysystemandintrathoracicorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of respiratory system and intrathoracic organs
required: sms:false

Overlappinglesionofretroperitoneumandperitoneum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of retroperitoneum and peritoneum
required: sms:false

Overlappinglesionofskin
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of skin
required: sms:false

Overlappinglesionofsmallintestine
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of small intestine
required: sms:false

Overlappinglesionofstomach
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of stomach
required: sms:false

Overlappinglesionoftongue
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of tongue
required: sms:false

Overlappinglesionoftonsil
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of tonsil
required: sms:false

Overlappinglesionofurinaryorgans
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of urinary organs
required: sms:false

Overlappinglesionofvulva
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of vulva
required: sms:false

Overlappinglesionsoforopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesions of oropharynx
required: sms:false

PalateNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Palate NOS
required: sms:false

PancreasNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pancreas NOS
required: sms:false

Pancreaticduct
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pancreatic duct
required: sms:false

Parametrium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Parametrium
required: sms:false

Parathyroidgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Parathyroid gland
required: sms:false

Paraurethralgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Paraurethral gland
required: sms:false

Parietallobe
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Parietal lobe
required: sms:false

Parotidgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Parotid gland
required: sms:false

Pelvicbonessacrumcoccyxandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pelvic bones sacrum coccyx and associated joints
required: sms:false

Pelviclymphnodes
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pelvic lymph nodes
required: sms:false

PelvisNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pelvis NOS
required: sms:false

PenisNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Penis NOS
required: sms:false

Peripheralnervesandautonomicnervoussystemofabdomen
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of abdomen
required: sms:false

Peripheralnervesandautonomicnervoussystemofheadfaceandneck
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of head face and neck
required: sms:false

Peripheralnervesandautonomicnervoussystemoflowerlimbandhip
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of lower limb and hip
required: sms:false

Peripheralnervesandautonomicnervoussystemofpelvis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of pelvis
required: sms:false

Peripheralnervesandautonomicnervoussystemofthorax
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of thorax
required: sms:false

PeripheralnervesandautonomicnervoussystemoftrunkNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of trunk NOS
required: sms:false

Peripheralnervesandautonomicnervoussystemofupperlimbandshoulder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peripheral nerves and autonomic nervous system of upper limb and shoulder
required: sms:false

PeritoneumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Peritoneum NOS
required: sms:false

PharynxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pharynx NOS
required: sms:false

Pinealgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pineal gland
required: sms:false

Pituitarygland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pituitary gland
required: sms:false

Placenta
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Placenta
required: sms:false

PleuraNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pleura NOS
required: sms:false

Postcricoidregion
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Postcricoid region
required: sms:false

Posteriormediastinum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Posterior mediastinum
required: sms:false

Posteriorwallofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Posterior wall of bladder
required: sms:false

Posteriorwallofhypopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Posterior wall of hypopharynx
required: sms:false

Posteriorwallofnasopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Posterior wall of nasopharynx
required: sms:false

Posteriorwalloforopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Posterior wall of oropharynx
required: sms:false

Prepuce
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Prepuce
required: sms:false

Prostategland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Prostate gland
required: sms:false

Pylorus
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pylorus
required: sms:false

Pyriformsinus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Pyriform sinus
required: sms:false

Rectosigmoidjunction
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Rectosigmoid junction
required: sms:false

RectumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Rectum NOS
required: sms:false

Renalpelvis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Renal pelvis
required: sms:false

ReticuloendothelialsystemNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Reticuloendothelial system NOS
required: sms:false

Retina
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Retina
required: sms:false

Retromolararea
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Retromolar area
required: sms:false

Retroperitoneum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Retroperitoneum
required: sms:false

Ribsternumclavicleandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Rib sternum clavicle and associated joints
required: sms:false

Roundligament
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Round ligament
required: sms:false

ScrotumNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Scrotum NOS
required: sms:false

Shortbonesoflowerlimbandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Short bones of lower limb and associated joints
required: sms:false

Shortbonesofupperlimbandassociatedjoints
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Short bones of upper limb and associated joints
required: sms:false

Sigmoidcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Sigmoid colon
required: sms:false

SkinoflipNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Skin of lip NOS
required: sms:false

Skinoflowerlimbandhip
type: Class
comment: TBD
subclass of: AdditionalTopography
subclass of: MelanomaBiopsyResectionSites
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: skin of lower limb and hip
required: sms:false

Skinofotherandunspecifiedpartsofface
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Skin of other and unspecified parts of face
required: sms:false

Skinofscalpandneck
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Skin of scalp and neck
required: sms:false

Skinoftrunk
type: Class
comment: TBD
subclass of: AdditionalTopography
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Skin of trunk
required: sms:false

Skinofupperlimbandshoulder
type: Class
comment: TBD
subclass of: AdditionalTopography
subclass of: MelanomaBiopsyResectionSites
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: skin of upper limb and shoulder
required: sms:false

SkinNOS
type: Class
comment: TBD
subclass of: AdditionalTopography
subclass of: MelanomaBiopsyResectionSites
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: skin NOS
required: sms:false

SmallintestineNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Small intestine NOS
required: sms:false

SoftpalateNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Soft palate NOS
required: sms:false

Specifiedpartsofperitoneum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Specified parts of peritoneum
required: sms:false

Spermaticcord
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Spermatic cord
required: sms:false

Sphenoidsinus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Sphenoid sinus
required: sms:false

Spinalcord
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Spinal cord
required: sms:false

Spinalmeninges
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Spinal meninges
required: sms:false

Spleen
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Spleen
required: sms:false

Splenicflexureofcolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Splenic flexure of colon
required: sms:false

StomachNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Stomach NOS
required: sms:false

Subglottis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Subglottis
required: sms:false

Sublingualgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Sublingual gland
required: sms:false

Submandibulargland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Submandibular gland
required: sms:false

Superiorwallofnasopharynx
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Superior wall of nasopharynx
required: sms:false

Supraglottis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Supraglottis
required: sms:false

Tailofpancreas
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Tail of pancreas
required: sms:false

Temporallobe
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Temporal lobe
required: sms:false

TestisNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Testis NOS
required: sms:false

Thoracicesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Thoracic esophagus
required: sms:false

ThoraxNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Thorax NOS
required: sms:false

Thymus
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Thymus
required: sms:false

Thyroidgland
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Thyroid gland
required: sms:false

TongueNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Tongue NOS
required: sms:false

TonsilNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Tonsil NOS
required: sms:false

Tonsillarfossa
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Tonsillar fossa
required: sms:false

Tonsillarpillar
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Tonsillar pillar
required: sms:false

Trachea
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Trachea
required: sms:false

Transversecolon
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Transverse colon
required: sms:false

Trigoneofbladder
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Trigone of bladder
required: sms:false

Undescendedtestis
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Undescended testis
required: sms:false

Unknownprimarysite
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: unknown primary site
required: sms:false

Uppergum
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper gum
required: sms:false

UpperlimbNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper limb NOS
required: sms:false

Upperlobelung
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper lobe lung
required: sms:false

UpperrespiratorytractNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper respiratory tract NOS
required: sms:false

Upperthirdofesophagus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper third of esophagus
required: sms:false

Upper-innerquadrantofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper-inner quadrant of breast
required: sms:false

Upper-outerquadrantofbreast
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Upper-outer quadrant of breast
required: sms:false

Urachus
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Urachus
required: sms:false

Ureter
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ureter
required: sms:false

Uretericorifice
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ureteric orifice
required: sms:false

Urethra
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Urethra
required: sms:false

UrinarysystemNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Urinary system NOS
required: sms:false

Uterineadnexa
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Uterine adnexa
required: sms:false

UterusNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Uterus NOS
required: sms:false

Uvula
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Uvula
required: sms:false

VaginaNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Vagina NOS
required: sms:false

Vallecula
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Vallecula
required: sms:false

VentralsurfaceoftongueNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ventral surface of tongue NOS
required: sms:false

VentricleNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Ventricle NOS
required: sms:false

Vertebralcolumn
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Vertebral column
required: sms:false

Vestibuleofmouth
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Vestibule of mouth
required: sms:false

VulvaNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Vulva NOS
required: sms:false

Waldeyerring
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Waldeyer ring
required: sms:false

BiliarytractNOS
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Biliary tract NOS
required: sms:false

Cheekmucosa
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Cheek mucosa
required: sms:false

Clitoris
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Clitoris
required: sms:false

Overlappinglesionofbiliarytract
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceAnatomicSite
subclass of: TreatmentAnatomicSite
subclass of: SiteofResectionorBiopsy
subclass of: TissueorOrganofOrigin
is part of: schema.biothings.io
display name: Overlapping lesion of biliary tract
required: sms:false

BrainAndOtherNervousSystem
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Brain And Other Nervous System
required: sms:false

FemaleBreast
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Female Breast
required: sms:false

InsituFemaleBreast
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: In situ Female Breast
required: sms:false

CervixUteri
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Cervix Uteri
required: sms:false

LessThanAge
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Less Than Age
required: sms:false

MalignantChildhoodNeoplasm
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Malignant Childhood Neoplasm
required: sms:false

ColonAndRectum
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Colon And Rectum
required: sms:false

Esophagus
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Esophagus
required: sms:false

KidneyAndRenalPelvis
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Kidney And Renal Pelvis
required: sms:false

LiverAndBileDuct
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Liver And Bile Duct
required: sms:false

LungAndBronchus
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Lung And Bronchus
required: sms:false

CutaneousMelanoma
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Cutaneous Melanoma
required: sms:false

Non-Hodgkin'sLymphoma
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Non-Hodgkin's Lymphoma
required: sms:false

OralCavityAndPharynx
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Oral Cavity And Pharynx
required: sms:false

Pancreas
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pancreas
required: sms:false

ProstateGland
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Prostate Gland
required: sms:false

Stomach
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Stomach
required: sms:false

ThyroidGland
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
is part of: schema.biothings.io
display name: Thyroid Gland
required: sms:false

Uterus
type: Class
comment: TBD
subclass of: NCIAtlasCancerSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Uterus
required: sms:false

Biochemical
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceType
is part of: schema.biothings.io
display name: Biochemical
required: sms:false

Distant
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceType
is part of: schema.biothings.io
display name: Distant
required: sms:false

Local
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceType
is part of: schema.biothings.io
display name: Local
required: sms:false

Regional
type: Class
comment: TBD
subclass of: ProgressionorRecurrenceType
is part of: schema.biothings.io
display name: Regional
required: sms:false

Antacids
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: Antacids
required: sms:false

H2Blockers
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: H2 Blockers
required: sms:false

MedicallyTreated
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: Medically Treated
required: sms:false

NoTreatment
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: No Treatment
required: sms:false

ProtonPumpInhibitors
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: Proton Pump Inhibitors
required: sms:false

SurgicallyTreated
type: Class
comment: TBD
subclass of: RefluxTreatmentType
is part of: schema.biothings.io
display name: Surgically Treated
required: sms:false

AlcoholConsumption
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Alcohol Consumption
required: sms:false

AlcoholicLiverDisease
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Alcoholic Liver Disease
required: sms:false

AllergyAnimalNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Animal NOS
required: sms:false

AllergyAnt
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Ant
required: sms:false

AllergyBee
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Bee
required: sms:false

AllergyCat
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Cat
required: sms:false

AllergyDairyorLactose
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Dairy or Lactose
required: sms:false

AllergyDog
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Dog
required: sms:false

AllergyEggs
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Eggs
required: sms:false

AllergyFoodNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Food NOS
required: sms:false

AllergyFruit
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Fruit
required: sms:false

AllergyMeat
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Meat
required: sms:false

AllergyMoldorDust
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Mold or Dust
required: sms:false

AllergyNuts
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Nuts
required: sms:false

AllergyProcessedFoods
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Processed Foods
required: sms:false

AllergySeafood
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Seafood
required: sms:false

AllergyWasp
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Allergy Wasp
required: sms:false

Alpha-1AntitrypsinDeficiency
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Alpha-1 Antitrypsin Deficiency
required: sms:false

AutoimmuneAtrophicChronicGastritis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Autoimmune Atrophic Chronic Gastritis
required: sms:false

Commonvariableimmunedeficiency(CVID)
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Common variable immune deficiency (CVID)
required: sms:false

DiabetesNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Diabetes NOS
required: sms:false

DiabetesTypeI
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Diabetes Type I
required: sms:false

DiabetesTypeII
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Diabetes Type II
required: sms:false

Endometriosis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Endometriosis
required: sms:false

Endosalpingiosis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Endosalpingiosis
required: sms:false

GastricPolyp(s)
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Gastric Polyp(s)
required: sms:false

Gilbert'sSyndrome
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Gilbert's Syndrome
required: sms:false

HayFever
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Hay Fever
required: sms:false

HelicobacterPylori-AssociatedGastritis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Helicobacter Pylori-Associated Gastritis
required: sms:false

HematologicDisorderNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Hematologic Disorder NOS
required: sms:false

Hemochromatosis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Hemochromatosis
required: sms:false

HepaticEncephalopathy
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Hepatic Encephalopathy
required: sms:false

HepatitisNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Hepatitis NOS
required: sms:false

HighGradeDysplasia
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: High Grade Dysplasia
required: sms:false

HIV
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: HIV
required: sms:false

IntestinalMetaplasia
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Intestinal Metaplasia
required: sms:false

LowGradeDysplasia
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Low Grade Dysplasia
required: sms:false

LymphocyticThyroiditis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Lymphocytic Thyroiditis
required: sms:false

NonalcoholicFattyLiverDisease
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Nonalcoholic Fatty Liver Disease
required: sms:false

OralContraceptives
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Oral Contraceptives
required: sms:false

ParasiticDiseaseofBiliaryTract
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Parasitic Disease of Biliary Tract
required: sms:false

RecurrentPyogenicCholangitis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Recurrent Pyogenic Cholangitis
required: sms:false

RefluxDisease
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Reflux Disease
required: sms:false

SensoryChanges
type: Class
comment: TBD
subclass of: FirstSymptomPriortoDiagnosis
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Sensory Changes
required: sms:false

http://schema.biothings.io/Seroustubalintraepithelialcarcinoma(STIC)
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Serous tubal intraepithelial carcinoma (STIC)
required: sms:false

Tattoo
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Tattoo
required: sms:false

ThyroidNodularHyperplasia
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Thyroid Nodular Hyperplasia
required: sms:false

TobaccoNOS
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Tobacco NOS
required: sms:false

TobaccoSmokeless
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Tobacco Smokeless
required: sms:false

TobaccoSmoking
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Tobacco Smoking
required: sms:false

UndescendedTestis
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Undescended Testis
required: sms:false

VisionChanges
type: Class
comment: TBD
subclass of: RiskFactor
is part of: schema.biothings.io
display name: Vision Changes
required: sms:false

HBVCoreAntibody
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: HBV Core Antibody
required: sms:false

HBVDNA
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: HBV DNA
required: sms:false

HBVGenotype
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: HBV Genotype
required: sms:false

HBVSurfaceAntibody
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: HBV Surface Antibody
required: sms:false

HCVGenotype
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: HCV Genotype
required: sms:false

HepatitisBSurfaceAntigen
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: Hepatitis B Surface Antigen
required: sms:false

HepatitisCAntibody
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: Hepatitis C Antibody
required: sms:false

HepatitisCVirusRNA
type: Class
comment: TBD
subclass of: ViralHepatitisSerologies
is part of: schema.biothings.io
display name: Hepatitis C Virus RNA
required: sms:false

InitialDiagnosis
type: Class
comment: TBD
subclass of: InitialDiseaseStatus
is part of: schema.biothings.io
display name: Initial Diagnosis
required: sms:false

ProgressiveDisease
type: Class
comment: TBD
subclass of: InitialDiseaseStatus
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Progressive Disease
required: sms:false

RecurrentDisease
type: Class
comment: TBD
subclass of: InitialDiseaseStatus
is part of: schema.biothings.io
display name: Recurrent Disease
required: sms:false

CompleteNecrosis(NoViableTumor)
type: Class
comment: TBD
subclass of: TreatmentEffect
is part of: schema.biothings.io
display name: Complete Necrosis (No Viable Tumor)
required: sms:false

IncompleteNecrosis(ViableTumorPresent)
type: Class
comment: TBD
subclass of: TreatmentEffect
is part of: schema.biothings.io
display name: Incomplete Necrosis (Viable Tumor Present)
required: sms:false

NoNecrosis
type: Class
comment: TBD
subclass of: TreatmentEffect
is part of: schema.biothings.io
display name: No Necrosis
required: sms:false

Adjuvant
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Adjuvant
required: sms:false

CancerControl
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Cancer Control
required: sms:false

Cure
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Cure
required: sms:false

Neoadjuvant
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Neoadjuvant
required: sms:false

Palliative
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Palliative
required: sms:false

Prevention
type: Class
comment: TBD
subclass of: TreatmentIntentType
is part of: schema.biothings.io
display name: Prevention
required: sms:false

CompleteResponse
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Complete Response
required: sms:false

MixedResponse
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Mixed Response
required: sms:false

NoMeasurableDisease
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: No Measurable Disease
required: sms:false

NoResponse
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: No Response
required: sms:false

PartialResponse
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Partial Response
required: sms:false

PersistentDisease
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Persistent Disease
required: sms:false

StableDisease
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Stable Disease
required: sms:false

TreatmentOngoing
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Treatment Ongoing
required: sms:false

TreatmentStoppedDuetoToxicity
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Treatment Stopped Due to Toxicity
required: sms:false

VeryGoodPartialResponse
type: Class
comment: TBD
subclass of: TreatmentOutcome
is part of: schema.biothings.io
display name: Very Good Partial Response
required: sms:false

AblationCryo
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation Cryo
required: sms:false

AblationEthanolInjection
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation Ethanol Injection
required: sms:false

AblationMicrowave
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation Microwave
required: sms:false

AblationNOS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation NOS
required: sms:false

AblationRadiofrequency
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation Radiofrequency
required: sms:false

AblationRadiosurgical
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ablation Radiosurgical
required: sms:false

AncillaryTreatment
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ancillary Treatment
required: sms:false

AntiseizureTreatment
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Antiseizure Treatment
required: sms:false

BisphosphonateTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Bisphosphonate Therapy
required: sms:false

BlindedStudyTreatmentunknown
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Blinded Study Treatment unknown
required: sms:false

BrachytherapyHighDose
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Brachytherapy High Dose
required: sms:false

BrachytherapyLowDose
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Brachytherapy Low Dose
required: sms:false

BrachytherapyNOS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Brachytherapy NOS
required: sms:false

Chemoembolization
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Chemoembolization
required: sms:false

Chemoprotectant
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Chemoprotectant
required: sms:false

Chemotherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Chemotherapy
required: sms:false

ConcurrentChemoradiation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Concurrent Chemoradiation
required: sms:false

Cryoablation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Cryoablation
required: sms:false

Embolization
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Embolization
required: sms:false

EthanolInjectionAblation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Ethanol Injection Ablation
required: sms:false

ExternalBeamRadiation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: External Beam Radiation
required: sms:false

HormoneTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Hormone Therapy
required: sms:false

I-131RadiationTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: I-131 Radiation Therapy
required: sms:false

InternalRadiation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Internal Radiation
required: sms:false

Immunotherapy(IncludingVaccines)
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Immunotherapy (Including Vaccines)
required: sms:false

IsolatedLimbPerfusion(ILP)
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Isolated Limb Perfusion (ILP)
required: sms:false

OrganTransplantation
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Organ Transplantation
required: sms:false

PharmaceuticalTherapyNOS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Pharmaceutical Therapy NOS
required: sms:false

Pleurodesis
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Pleurodesis
required: sms:false

Radiation2DConventional
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation 2D Conventional
required: sms:false

Radiation3DConformal
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation 3D Conformal
required: sms:false

RadiationCombination
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Combination
required: sms:false

RadiationCyberknife
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Cyberknife
required: sms:false

RadiationExternalBeam
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation External Beam
required: sms:false

RadiationImplants
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Implants
required: sms:false

RadiationIntensity-ModulatedRadiotherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Intensity-Modulated Radiotherapy
required: sms:false

RadiationInternal
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Internal
required: sms:false

RadiationProtonBeam
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Proton Beam
required: sms:false

RadiationRadioisotope
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Radioisotope
required: sms:false

RadiationStereotactic/GammaKnife/SRS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Stereotactic/Gamma Knife/SRS
required: sms:false

RadiationSystemic
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Systemic
required: sms:false

RadiationTherapyNOS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiation Therapy NOS
required: sms:false

RadioactiveIodineTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radioactive Iodine Therapy
required: sms:false

Radioembolization
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radioembolization
required: sms:false

RadiosensitizingAgent
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Radiosensitizing Agent
required: sms:false

StemCellTreatment
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Treatment
required: sms:false

StemCellTransplantationAutologous
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Autologous
required: sms:false

StemCellTransplantationDoubleAutologous
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Double Autologous
required: sms:false

StemCellTransplantationAllogeneic
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Allogeneic
required: sms:false

StemCellTransplantationNon-Myeloablative
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Non-Myeloablative
required: sms:false

StemCellTransplantationSyngenic
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Syngenic
required: sms:false

StemCellTransplantationHaploidentical
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation Haploidentical
required: sms:false

StemCellTransplantationNOS
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stem Cell Transplantation NOS
required: sms:false

StereotacticRadiosurgery
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Stereotactic Radiosurgery
required: sms:false

SteroidTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Steroid Therapy
required: sms:false

Surgery
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Surgery
required: sms:false

TargetedMolecularTherapy
type: Class
comment: TBD
subclass of: TreatmentType
is part of: schema.biothings.io
display name: Targeted Molecular Therapy
required: sms:false

AdverseTherapyEvent
type: Class
comment: TBD
subclass of: ReasonTreatmentEnded
is part of: schema.biothings.io
display name: Adverse Therapy Event
required: sms:false

CourseofTherapyCompleted
type: Class
comment: TBD
subclass of: ReasonTreatmentEnded
is part of: schema.biothings.io
display name: Course of Therapy Completed
required: sms:false

Death
type: Class
comment: TBD
subclass of: ReasonTreatmentEnded
is part of: schema.biothings.io
display name: Death
required: sms:false

DiseaseProgression
type: Class
comment: TBD
subclass of: ReasonTreatmentEnded
is part of: schema.biothings.io
display name: Disease Progression
required: sms:false

WithdrawalbySubject
type: Class
comment: TBD
subclass of: ReasonTreatmentEnded
is part of: schema.biothings.io
display name: Withdrawal by Subject
required: sms:false

A081105
type: Class
comment: TBD
subclass of: TreatmentArm
is part of: schema.biothings.io
display name: A081105
required: sms:false

E4512
type: Class
comment: TBD
subclass of: TreatmentArm
is part of: schema.biothings.io
display name: E4512
required: sms:false

EA5142
type: Class
comment: TBD
subclass of: TreatmentArm
is part of: schema.biothings.io
display name: EA5142
required: sms:false

CGy
type: Class
comment: TBD
subclass of: TreatmentDoseUnits
is part of: schema.biothings.io
display name: cGy
required: sms:false

Gy
type: Class
comment: TBD
subclass of: TreatmentDoseUnits
is part of: schema.biothings.io
display name: Gy
required: sms:false

EveryHour
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Every Hour
required: sms:false

FiveTimesDaily
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Five Times Daily
required: sms:false

FourTimesDaily
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Four Times Daily
required: sms:false

ThreeTimesDaily
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Three Times Daily
required: sms:false

TwiceDaily
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Twice Daily
required: sms:false

Every24Hours
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Every 24 Hours
required: sms:false

EveryOtherDay
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Every Other Day
required: sms:false

TwiceWeekly
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Twice Weekly
required: sms:false

OnceWeekly
type: Class
comment: TBD
subclass of: TreatmentFrequency
is part of: schema.biothings.io
display name: Once Weekly
required: sms:false

Absent
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
subclass of: MicropapillaryFeatures
subclass of: NonNodalRegionalDisease
subclass of: OvarianSurfaceInvolvement
subclass of: AnaplasiaPresentType
subclass of: MLH1PromoterMethylationStatus
subclass of: CutaneousMelanomaTumorInfiltratingLymphocytes
subclass of: CutaneousMelanomaTumorRegressionRange
subclass of: CutaneousMelanomaUlceration
is part of: schema.biothings.io
display name: Absent
required: sms:false

NO
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: NO
required: sms:false

YES
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: YES
required: sms:false

Nosourcedocumentation
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: No source documentation
required: sms:false

Notsampledordissected
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: Not sampled or dissected
required: sms:false

Present
type: Class
comment: TBD
subclass of: MicropapillaryFeatures
subclass of: OvarianSurfaceInvolvement
subclass of: CutaneousMelanomaUlceration
subclass of: NonNodalRegionalDisease
subclass of: MLH1PromoterMethylationStatus
subclass of: AnaplasiaPresentType
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: Present
required: sms:false

Present-extensive
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: Present - extensive
required: sms:false

Present-minimal
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: Present - minimal
required: sms:false

UNKNOWN
type: Class
comment: TBD
subclass of: TumorExtranodalExtensionIndicator
is part of: schema.biothings.io
display name: UNKNOWN
required: sms:false

GrossTotalResection
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Gross Total Resection
required: sms:false

OpenBiopsy
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Open Biopsy
required: sms:false

SubtotalResection
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Subtotal Resection
required: sms:false

ExtensiveSubtotal
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Extensive Subtotal
required: sms:false

Minor
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Minor
required: sms:false

Optimaldebulking
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Optimal debulking
required: sms:false

Partialdebulking
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Partial debulking
required: sms:false

Segmental
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Segmental
required: sms:false

Suboptimal
type: Class
comment: TBD
subclass of: MRDALLDiagnosticSensitivity
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Suboptimal
required: sms:false

Suboptimaldebulking
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: Suboptimal debulking
required: sms:false

NTR
type: Class
comment: TBD
subclass of: ExtentofTumorResection
is part of: schema.biothings.io
display name: NTR
required: sms:false

DuctalCarcinomaInSitu
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Ductal Carcinoma In Situ
required: sms:false

PancreaticIntraductalPapillary-MucinousNeoplasm
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Pancreatic Intraductal Papillary-Mucinous Neoplasm
required: sms:false

AtypicalAdenomatousLungHyperplasia
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Atypical Adenomatous Lung Hyperplasia
required: sms:false

PancreaticIntraepithelialNeoplasia
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Pancreatic Intraepithelial Neoplasia
required: sms:false

ProstaticIntraepithelialNeoplasia
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Prostatic Intraepithelial Neoplasia
required: sms:false

Melanomainsitu
type: Class
comment: TBD
subclass of: PrecancerousConditionType
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Melanoma in situ
required: sms:false

Superficialspreading
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Superficial spreading
required: sms:false

Lentigomalignatype
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Lentigo maligna type
required: sms:false

Acral-lentiginous
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Acral-lentiginous
required: sms:false

Melanomainsituarisinginagiantcongenitalnevus
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Melanoma in situ arising in a giant congenital nevus
required: sms:false

Melanomainsitunototherwiseclassified
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Melanoma in situ not otherwise classified
required: sms:false

Invasivemelanoma
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Invasive melanoma
required: sms:false

Squamouscarcinomainsitu
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Squamous carcinoma in situ
required: sms:false

Neuroendocrinecellhyperplasia
type: Class
comment: TBD
subclass of: PrecancerousConditionType
is part of: schema.biothings.io
display name: Neuroendocrine cell hyperplasia
required: sms:false

Abdomentotal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Abdomen total
required: sms:false

AbdominalWall
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Abdominal Wall
required: sms:false

Acetabulum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Acetabulum
required: sms:false

Adenoid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Adenoid
required: sms:false

Adipose
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Adipose
required: sms:false

Adrenal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Adrenal
required: sms:false

AlveolarRidge
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Alveolar Ridge
required: sms:false

AmnioticFluid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Amniotic Fluid
required: sms:false

AnalSphincter
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Anal Sphincter
required: sms:false

Ankle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ankle
required: sms:false

Anorectum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Anorectum
required: sms:false

AntecubitalFossa
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Antecubital Fossa
required: sms:false

Antrum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Antrum
required: sms:false

Anus
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Anus
required: sms:false

Aorta
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Aorta
required: sms:false

AorticBody
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Aortic Body
required: sms:false

AqueousFluid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Aqueous Fluid
required: sms:false

Arm
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Arm
required: sms:false

Artery
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Artery
required: sms:false

AscendingColon
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ascending Colon
required: sms:false

AscendingColonHepaticFlexure
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ascending Colon Hepatic Flexure
required: sms:false

AuditoryCanal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Auditory Canal
required: sms:false

AutonomicNervousSystem
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Autonomic Nervous System
required: sms:false

Axilla
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Axilla
required: sms:false

Back
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Back
required: sms:false

BileDuct
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bile Duct
required: sms:false

BloodVessel
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Blood Vessel
required: sms:false

Bodytotal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Body total
required: sms:false

Bone
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bone
required: sms:false

BoneMarrow
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bone Marrow
required: sms:false

Bonenon-spine
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bone non-spine
required: sms:false

Bowel
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bowel
required: sms:false

Brain
type: Class
comment: TBD
subclass of: GliomaSpecificMetastasisSites
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Brain
required: sms:false

BrainStem
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Brain Stem
required: sms:false

Breast
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Breast
required: sms:false

BroadLigament
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Broad Ligament
required: sms:false

Bronchiole
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bronchiole
required: sms:false

Bronchus
type: Class
comment: TBD
subclass of: LungTumorLobeBronchialLocation
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Bronchus
required: sms:false

Brow
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Brow
required: sms:false

BuccalCavity
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Buccal Cavity
required: sms:false

BuccalMucosa
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Buccal Mucosa
required: sms:false

Buttock
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Buttock
required: sms:false

Calf
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Calf
required: sms:false

Capillary
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Capillary
required: sms:false

Cardia
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cardia
required: sms:false

Carina
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Carina
required: sms:false

CarotidArtery
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Carotid Artery
required: sms:false

CarotidBody
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Carotid Body
required: sms:false

Cartilage
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cartilage
required: sms:false

Cell-Line
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cell-Line
required: sms:false

CentralNervousSystem
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Central Nervous System
required: sms:false

Cerebellum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cerebellum
required: sms:false

CerebralCortex
type: Class
comment: TBD
subclass of: SupratentorialLocalization
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cerebral Cortex
required: sms:false

CerebrospinalFluid
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cerebrospinal Fluid
required: sms:false

CervicalSpine
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cervical Spine
required: sms:false

Cervix
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Cervix
required: sms:false

Chest
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Chest
required: sms:false

ChestWall
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Chest Wall
required: sms:false

Chin
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Chin
required: sms:false

Clavicle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Clavicle
required: sms:false

Colon
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Colon
required: sms:false

ColonMucosaOnly
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Colon Mucosa Only
required: sms:false

CommonDuct
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Common Duct
required: sms:false

ConnectiveTissue
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Connective Tissue
required: sms:false

Dermal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Dermal
required: sms:false

DescendingColon
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Descending Colon
required: sms:false

Diaphragm
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Diaphragm
required: sms:false

DistantSite
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Distant Site
required: sms:false

Ear
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ear
required: sms:false

EarCanal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ear Canal
required: sms:false

EarPinna(External)
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ear Pinna (External)
required: sms:false

Elbow
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Elbow
required: sms:false

EndocrineGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Endocrine Gland
required: sms:false

EpiduralSpace
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Epidural Space
required: sms:false

Epitrochlear
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Epitrochlear
required: sms:false

EsophagogastricJunction
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Esophagogastric Junction
required: sms:false

EsophagusMucosaOnly
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Esophagus Mucosa Only
required: sms:false

Eye
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Eye
required: sms:false

FallopianTube
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Fallopian Tube
required: sms:false

FemoralArtery
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Femoral Artery
required: sms:false

FemoralVein
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Femoral Vein
required: sms:false

Femur
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Femur
required: sms:false

Fibroblasts
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Fibroblasts
required: sms:false

Fibula
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Fibula
required: sms:false

Finger
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Finger
required: sms:false

FloorofMouth
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Floor of Mouth
required: sms:false

Fluid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Fluid
required: sms:false

Foot
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Foot
required: sms:false

Forearm
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Forearm
required: sms:false

Forehead
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Forehead
required: sms:false

Foreskin
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Foreskin
required: sms:false

FrontalCortex
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Frontal Cortex
required: sms:false

FrontalLobe
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Frontal Lobe
required: sms:false

FundusofStomach
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Fundus of Stomach
required: sms:false

Ganglia
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ganglia
required: sms:false

GastroesophagealJunction
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Gastroesophageal Junction
required: sms:false

GastrointestinalTract
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Gastrointestinal Tract
required: sms:false

GastrointestinalIntestine
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Gastrointestinal Intestine
required: sms:false

GenitourinaryNOS
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Genitourinary NOS
required: sms:false

Groin
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Groin
required: sms:false

Gum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Gum
required: sms:false

Hand
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hand
required: sms:false

HardPalate
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hard Palate
required: sms:false

HeadFaceOrNeckNos
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Head Face Or Neck Nos
required: sms:false

HeadandNeck
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Head and Neck
required: sms:false

Hepatic
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hepatic
required: sms:false

HepaticDuct
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hepatic Duct
required: sms:false

HepaticVein
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hepatic Vein
required: sms:false

Hilar
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hilar
required: sms:false

Hip
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hip
required: sms:false

Hippocampus
type: Class
comment: TBD
subclass of: CNSTumorPrimaryAnatomicSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hippocampus
required: sms:false

Humerus
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Humerus
required: sms:false

Hypopharynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Hypopharynx
required: sms:false

IleocecalValve
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ileocecal Valve
required: sms:false

Ilium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ilium
required: sms:false

IndexFinger
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Index Finger
required: sms:false

Ischium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ischium
required: sms:false

IsletCells
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Islet Cells
required: sms:false

Jaw
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Jaw
required: sms:false

Joint
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Joint
required: sms:false

Kidney
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Kidney
required: sms:false

Knee
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Knee
required: sms:false

LacrimalGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lacrimal Gland
required: sms:false

LargeBowel
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Large Bowel
required: sms:false

Laryngopharynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Laryngopharynx
required: sms:false

Larynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Larynx
required: sms:false

Leg
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Leg
required: sms:false

Leptomeninges
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Leptomeninges
required: sms:false

Ligament
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ligament
required: sms:false

Lip
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lip
required: sms:false

LumbarSpine
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lumbar Spine
required: sms:false

Lung
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lung
required: sms:false

LymphNode
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node
required: sms:false

LymphNode(s)Axilla
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Axilla
required: sms:false

LymphNode(s)Cervical
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Cervical
required: sms:false

LymphNode(s)Distant
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Distant
required: sms:false

LymphNode(s)Epitrochlear
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Epitrochlear
required: sms:false

LymphNode(s)Femoral
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Femoral
required: sms:false

LymphNode(s)Hilar
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Hilar
required: sms:false

LymphNode(s)Iliac-Common
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Iliac-Common
required: sms:false

LymphNode(s)Iliac-External
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Iliac-External
required: sms:false

LymphNode(s)Inguinal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Inguinal
required: sms:false

LymphNode(s)InternalMammary
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Internal Mammary
required: sms:false

LymphNode(s)Mammary
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Mammary
required: sms:false

LymphNode(s)Mediastinal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Mediastinal
required: sms:false

LymphNode(s)Mesenteric
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Mesenteric
required: sms:false

LymphNode(s)Occipital
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Occipital
required: sms:false

LymphNode(s)Paraaortic
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Paraaortic
required: sms:false

LymphNode(s)Parotid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Parotid
required: sms:false

LymphNode(s)Pelvic
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Pelvic
required: sms:false

LymphNode(s)Popliteal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Popliteal
required: sms:false

LymphNode(s)Regional
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Regional
required: sms:false

LymphNode(s)Retroperitoneal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Retroperitoneal
required: sms:false

LymphNode(s)Scalene
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Scalene
required: sms:false

LymphNode(s)Splenic
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Splenic
required: sms:false

LymphNode(s)Subclavicular
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Subclavicular
required: sms:false

LymphNode(s)Submandibular
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Submandibular
required: sms:false

LymphNode(s)Supraclavicular
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Lymph Node(s) Supraclavicular
required: sms:false

Mantle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mantle
required: sms:false

Maxilla
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Maxilla
required: sms:false

MediastinalSoftTissue
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mediastinal Soft Tissue
required: sms:false

Mediastinum
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mediastinum
required: sms:false

Mesentery
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mesentery
required: sms:false

Mesothelium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mesothelium
required: sms:false

MiddleFinger
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Middle Finger
required: sms:false

Mitochondria
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Mitochondria
required: sms:false

Muscle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Muscle
required: sms:false

Nails
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nails
required: sms:false

NasalCavity
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nasal Cavity
required: sms:false

NasalSoftTissue
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nasal Soft Tissue
required: sms:false

Nasopharynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nasopharynx
required: sms:false

Neck
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Neck
required: sms:false

Nerve
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nerve
required: sms:false

Nerve(s)Cranial
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Nerve(s) Cranial
required: sms:false

OccipitalCortex
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Occipital Cortex
required: sms:false

OcularOrbits
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ocular Orbits
required: sms:false

Omentum
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Omentum
required: sms:false

OralCavity
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Oral Cavity
required: sms:false

OralCavityMucosaOnly
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Oral Cavity Mucosa Only
required: sms:false

Oropharynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Oropharynx
required: sms:false

Palate
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Palate
required: sms:false

ParaspinalGanglion
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Paraspinal Ganglion
required: sms:false

Parathyroid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Parathyroid
required: sms:false

ParotidGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Parotid Gland
required: sms:false

Patella
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Patella
required: sms:false

Pelvis
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pelvis
required: sms:false

Penis
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Penis
required: sms:false

Pericardium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pericardium
required: sms:false

PeriorbitalSoftTissue
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Periorbital Soft Tissue
required: sms:false

PeritonealCavity
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Peritoneal Cavity
required: sms:false

Peritoneum
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Peritoneum
required: sms:false

Pharynx
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pharynx
required: sms:false

Pineal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pineal
required: sms:false

PinealGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pineal Gland
required: sms:false

PituitaryGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pituitary Gland
required: sms:false

Pleura
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pleura
required: sms:false

PoplitealFossa
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Popliteal Fossa
required: sms:false

Pouch
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Pouch
required: sms:false

PrimaryTumorField
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Primary Tumor Field
required: sms:false

Primarytumorsite
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Primary tumor site
required: sms:false

Prostate
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Prostate
required: sms:false

ProstateBed
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Prostate Bed
required: sms:false

ProstateSeminalVesiclesandLymphNodes
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Prostate Seminal Vesicles and Lymph Nodes
required: sms:false

RectosigmoidJunction
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Rectosigmoid Junction
required: sms:false

Rectum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Rectum
required: sms:false

RegionalSite
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Regional Site
required: sms:false

Retro-OrbitalRegion
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Retro-Orbital Region
required: sms:false

Rib
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Rib
required: sms:false

RingFinger
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Ring Finger
required: sms:false

RoundLigament
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Round Ligament
required: sms:false

Sacrum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sacrum
required: sms:false

SalivaryGland
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Salivary Gland
required: sms:false

Scalp
type: Class
comment: TBD
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Scalp
required: sms:false

Scapula
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Scapula
required: sms:false

SciaticNerve
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sciatic Nerve
required: sms:false

Scrotum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Scrotum
required: sms:false

SeminalVesicle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Seminal Vesicle
required: sms:false

Shoulder
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Shoulder
required: sms:false

SigmoidColon
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sigmoid Colon
required: sms:false

Sinus
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sinus
required: sms:false

Sinus(es)Maxillary
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sinus(es) Maxillary
required: sms:false

SkeletalMuscle
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skeletal Muscle
required: sms:false

Skin
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skin
required: sms:false

Skinlowerextremitylocal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skin lower extremity local
required: sms:false

Skintotal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skin total
required: sms:false

Skintrunklocal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skin trunk local
required: sms:false

Skinupperextremitylocal
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skin upper extremity local
required: sms:false

Skull
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Skull
required: sms:false

SmallBowel
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Small Bowel
required: sms:false

SmallBowelMucosaOnly
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Small Bowel Mucosa Only
required: sms:false

SmallFinger
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Small Finger
required: sms:false

SoftTissue
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Soft Tissue
required: sms:false

SpinalColumn
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Spinal Column
required: sms:false

SpinalCord
type: Class
comment: TBD
subclass of: SupratentorialLocalization
subclass of: MetastasisatDiagnosisSite
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Spinal Cord
required: sms:false

Spine
type: Class
comment: TBD
subclass of: GliomaSpecificMetastasisSites
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Spine
required: sms:false

SplenicFlexure
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Splenic Flexure
required: sms:false

Sternum
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Sternum
required: sms:false

StomachMucosaOnly
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Stomach Mucosa Only
required: sms:false

SubcutaneousTissue
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Subcutaneous Tissue
required: sms:false

Synovium
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Synovium
required: sms:false

TemporalCortex
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Temporal Cortex
required: sms:false

Tendon
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Tendon
required: sms:false

Testis
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Testis
required: sms:false

Thigh
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Thigh
required: sms:false

ThoracicSpine
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Thoracic Spine
required: sms:false

Thorax
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Thorax
required: sms:false

Throat
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Throat
required: sms:false

Thumb
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Thumb
required: sms:false

Thyroid
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Thyroid
required: sms:false

Tibia
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Tibia
required: sms:false

Tongue
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Tongue
required: sms:false

Tonsil
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Tonsil
required: sms:false

Tonsil(Pharyngeal)
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Tonsil (Pharyngeal)
required: sms:false

Trachea/MajorBronchi
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Trachea / Major Bronchi
required: sms:false

TransverseColon
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Transverse Colon
required: sms:false

Trunk
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Trunk
required: sms:false

UmbilicalCord
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Umbilical Cord
required: sms:false

UrinaryTract
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Urinary Tract
required: sms:false

VasDeferens
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Vas Deferens
required: sms:false

Vein
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Vein
required: sms:false

Venous
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Venous
required: sms:false

Vertebra
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Vertebra
required: sms:false

Vulva
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Vulva
required: sms:false

WhiteBloodCells
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: White Blood Cells
required: sms:false

Wrist
type: Class
comment: TBD
subclass of: PriorSitesofRadiation
is part of: schema.biothings.io
display name: Wrist
required: sms:false

NotDone
type: Class
comment: TBD
subclass of: Immunosuppression
subclass of: COVID19OccurrenceIndicator
subclass of: COVID19PositiveLabTestIndicator
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: Not Done
required: sms:false

Anticoagulantagents
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Anticoagulant agents
required: sms:false

Anticonvulsant
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Anticonvulsant
required: sms:false

Antifungal
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Antifungal
required: sms:false

Antiplateletagents
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Antiplatelet agents
required: sms:false

http://schema.biothings.io/Antidepressants-ModerateCYP2D6inhibitors
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Antidepressants-Moderate CYP2D6 inhibitors
required: sms:false

Antidepressants-StrongCYP2D6inhibitors
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Antidepressants-Strong CYP2D6 inhibitors
required: sms:false

http://schema.biothings.io/Antidepressants-weakCYP2D2inhibitorsornon-inhibitors
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Antidepressants-weak CYP2D2 inhibitors or non-inhibitors
required: sms:false

Anxiolyticsorsedatives
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Anxiolytics or sedatives
required: sms:false

Aspirin
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Aspirin
required: sms:false

Bisphosphonatesfortreatment/preventionofboneloss
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Bisphosphonates for treatment/prevention of bone loss
required: sms:false

Corticosteroid
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Corticosteroid
required: sms:false

COX-2inhibitor
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: COX-2 inhibitor
required: sms:false

Decadron
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Decadron
required: sms:false

Diabetes-Insulin
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Diabetes-Insulin
required: sms:false

Diabetes-Metformincontainingagents
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Diabetes-Metformin containing agents
required: sms:false

Growthfactor
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Growth factor
required: sms:false

Intravaginalestrogenpreparations
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Intravaginal estrogen preparations
required: sms:false

Lipid-loweringdrugs
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Lipid-lowering drugs
required: sms:false

Non-prescriptionsupplementsformemory
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Non-prescription supplements for memory
required: sms:false

Non-prescriptionsupplementsforreliefofhotflashes
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Non-prescription supplements for relief of hot flashes
required: sms:false

Non-steroidalanti-inflammatoryagents
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Non-steroidal anti-inflammatory agents
required: sms:false

Opioids
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Opioids
required: sms:false

Prescriptionmedicationsformemory
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Prescription medications for memory
required: sms:false

Prescriptionmedicationsforreliefofhotflashes
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Prescription medications for relief of hot flashes
required: sms:false

Prophylacticantiplatelettherapy
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Prophylactic antiplatelet therapy
required: sms:false

Tricyclicantidepressants
type: Class
comment: TBD
subclass of: ConcomitantMedicationReceivedType
is part of: schema.biothings.io
display name: Tricyclic antidepressants
required: sms:false

VitalStatusAlive
type: Class
comment: TBD
subclass of: FamilyMemberVitalStatusIndicator
is part of: schema.biothings.io
display name: Vital Status Alive
required: sms:false

VitalStatusDead
type: Class
comment: TBD
subclass of: FamilyMemberVitalStatusIndicator
is part of: schema.biothings.io
display name: Vital Status Dead
required: sms:false

Patientcurrentlyhassymptoms
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Patient currently has symptoms
required: sms:false

Patienthadsymptomsbutnowisfullyrecovered
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Patient had symptoms but now is fully recovered
required: sms:false

PatientneverhadanysymptomsofCOVID-19
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Patient never had any symptoms of COVID-19
required: sms:false

StatusunknownduetogeneralCOVID-19relatedtravelrestrictions
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Status unknown due to general COVID-19 related travel restrictions
required: sms:false

Statusunknownduetolackofdisease/tumorassessmentduetoCOVID-19diagnosis
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Status unknown due to lack of disease/tumor assessment due to COVID-19 diagnosis
required: sms:false

Statusunknownduetootherreasons
type: Class
comment: TBD
subclass of: COVID19CurrentStatus
is part of: schema.biothings.io
display name: Status unknown due to other reasons
required: sms:false

SARS-CoV-2IgMantibodypositive
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgM antibody positive
required: sms:false

SARS-CoV-2IgGantibodypositive
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgG antibody positive
required: sms:false

SARS-CoV-2IgG/IgMantibodypositive
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgG/IgM antibody positive
required: sms:false

SARS-CoV-2IgMantibodynegative
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgM antibody negative
required: sms:false

SARS-CoV-2IgGantibodynegative
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgG antibody negative
required: sms:false

SARS-CoV-2IgG/IgMantibodynegative
type: Class
comment: TBD
subclass of: COVID19AntibodyTesting
is part of: schema.biothings.io
display name: SARS-CoV-2 IgG/IgM antibody negative
required: sms:false

Cardiaccomplications
type: Class
comment: TBD
subclass of: COVID19ComplicationsSeverity
is part of: schema.biothings.io
display name: Cardiac complications
required: sms:false

Pulmonarycomplications
type: Class
comment: TBD
subclass of: COVID19ComplicationsSeverity
is part of: schema.biothings.io
display name: Pulmonary complications
required: sms:false

Systemiccomplications
type: Class
comment: TBD
subclass of: COVID19ComplicationsSeverity
is part of: schema.biothings.io
display name: Systemic complications
required: sms:false

Current
type: Class
comment: TBD
subclass of: Ecigvapeuse
is part of: schema.biothings.io
display name: Current
required: sms:false

Former
type: Class
comment: TBD
subclass of: Ecigvapeuse
is part of: schema.biothings.io
display name: Former
required: sms:false

Never
type: Class
comment: TBD
subclass of: HistoryofTanningBedUse
subclass of: Ecigvapeuse
is part of: schema.biothings.io
display name: Never
required: sms:false

Alpha-1antitrypsin
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Alpha-1 antitrypsin
required: sms:false

Attenuatedfamilialadenomatouspolyposis
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Attenuated familial adenomatous polyposis
required: sms:false

BAP1mutantdisease
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: BAP1 mutant disease
required: sms:false

Biliarydisorder
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Biliary disorder
required: sms:false

Birt-Hogg-Dubesyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Birt-Hogg-Dube syndrome
required: sms:false

Carneycomplex
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Carney complex
required: sms:false

Cirrhosisunknownetiology
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Cirrhosis unknown etiology
required: sms:false

Constitutionalmismatchrepairdeficiency
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Constitutional mismatch repair deficiency
required: sms:false

Familialadenomatouspolyposis
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Familial adenomatous polyposis
required: sms:false

Familialgastrointestinalstromaltumor
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Familial gastrointestinal stromal tumor
required: sms:false

Familialpancreaticcancer
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Familial pancreatic cancer
required: sms:false

Familialprostatecancer
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Familial prostate cancer
required: sms:false

Familialrenalcancer
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Familial renal cancer
required: sms:false

Fanconianemia
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Fanconi anemia
required: sms:false

Gorlinsyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Gorlin syndrome
required: sms:false

Hereditarybreast–ovariancancersyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary breast–ovarian cancer syndrome
required: sms:false

Hereditarydiffusegastriccancer
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary diffuse gastric cancer
required: sms:false

Hereditaryleiomyoma-renalcellcarcinoma
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary leiomyoma-renal cell carcinoma
required: sms:false

Hereditarymelanoma
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary melanoma
required: sms:false

Hereditarymixedpolyposissyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary mixed polyposis syndrome
required: sms:false

HereditarypapillaryRCC
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary papillary RCC
required: sms:false

Hereditarypapillaryrenalcellcarcinoma
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary papillary renal cell carcinoma
required: sms:false

Hereditaryparaganglioma–pheochromocytomasyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary paraganglioma–pheochromocytoma syndrome
required: sms:false

Hereditaryrenaloncocytoma
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary renal oncocytoma
required: sms:false

Hereditaryretinoblastoma
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Hereditary retinoblastoma
required: sms:false

Juvenilepolyposissyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Juvenile polyposis syndrome
required: sms:false

Li-Fraumenisyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Li-Fraumeni syndrome
required: sms:false

Lynchsyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Lynch syndrome
required: sms:false

Melanoma–astrocytomasyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Melanoma–astrocytoma syndrome
required: sms:false

MultipleendocrineneoplasiatypeI
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Multiple endocrine neoplasia type I
required: sms:false

MultipleendocrineneoplasiatypeII
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Multiple endocrine neoplasia type II
required: sms:false

MUTYH-associatedpolyposis
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: MUTYH-associated polyposis
required: sms:false

Nevoidbasalcellcarcinomasyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Nevoid basal cell carcinoma syndrome
required: sms:false

Peutz–Jegherssyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Peutz–Jeghers syndrome
required: sms:false

Cowdensyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Cowden syndrome
required: sms:false

RhabdoidtumorpredispositionsyndrometypeI
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Rhabdoid tumor predisposition syndrome type I
required: sms:false

RhabdoidtumorpredispositionsyndrometypeII
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Rhabdoid tumor predisposition syndrome type II
required: sms:false

Rubinstein-Taybisyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Rubinstein-Taybi syndrome
required: sms:false

SDHassociatedrenalcancer
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: SDH associated renal cancer
required: sms:false

Serratedpolyposissyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Serrated polyposis syndrome
required: sms:false

Tuberoussclerosiscomplex
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Tuberous sclerosis complex
required: sms:false

Turcotsyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: Turcot syndrome
required: sms:false

VonHippel-LindauSyndrome
type: Class
comment: TBD
subclass of: HereditaryCancerPredispositionSyndrome
is part of: schema.biothings.io
display name: von Hippel-Lindau Syndrome
required: sms:false

APCmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: APC mutation
required: sms:false

ALKmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ALK mutation
required: sms:false

ARFmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ARF mutation
required: sms:false

ATMmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ATM mutation
required: sms:false

ATRXmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ATRX mutation
required: sms:false

ACVR1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ACVR1 mutation
required: sms:false

BAP1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BAP1 mutation
required: sms:false

BMPR1Amutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BMPR1A mutation
required: sms:false

BLMmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BLM mutation
required: sms:false

BRCA1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BRCA1 mutation
required: sms:false

BRCA1and2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BRCA1 and 2 mutation
required: sms:false

BRCA2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BRCA2 mutation
required: sms:false

BRAFmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: BRAF mutation
required: sms:false

CDH1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: CDH1 mutation
required: sms:false

CDKN2Amutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: CDKN2A mutation
required: sms:false

CDKN2Aandp14ARFmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: CDKN2A and p14ARF mutation
required: sms:false

CHKmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: CHK mutation
required: sms:false

ETV6mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ETV6 mutation
required: sms:false

EGFRmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: EGFR mutation
required: sms:false

FHmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: FH mutation
required: sms:false

FLCNmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: FLCN mutation
required: sms:false

GREM1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: GREM1 mutation
required: sms:false

HOXB13mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: HOXB13 mutation
required: sms:false

H3K27Mmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: H3K27M mutation
required: sms:false

H3G34R/Vmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: H3G34R/V mutation
required: sms:false

IKZF1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: IKZF1 mutation
required: sms:false

KITmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: KIT mutation
required: sms:false

KRASmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: KRAS mutation
required: sms:false

MAXmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MAX mutation
required: sms:false

MEN1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MEN1 mutation
required: sms:false

METmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MET mutation
required: sms:false

MLH1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MLH1 mutation
required: sms:false

MSH2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MSH2 mutation
required: sms:false

MSH6mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MSH6 mutation
required: sms:false

MUTYHmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: MUTYH mutation
required: sms:false

NF1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: NF1 mutation
required: sms:false

NF2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: NF2 mutation
required: sms:false

P14ARFmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: p14ARF mutation
required: sms:false

PALB2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PALB2 mutation
required: sms:false

PAX5mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PAX5 mutation
required: sms:false

PDGFRAmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PDGFRA mutation
required: sms:false

PHOX2Bmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PHOX2B mutation
required: sms:false

PMS2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PMS2 mutation
required: sms:false

PolDmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PolD mutation
required: sms:false

PolEmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PolE mutation
required: sms:false

POT1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: POT1 mutation
required: sms:false

PRKAR1Amutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PRKAR1A mutation
required: sms:false

PTCHmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PTCH mutation
required: sms:false

PTENmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: PTEN mutation
required: sms:false

ROS1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: ROS1 mutation
required: sms:false

RB1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: RB1 mutation
required: sms:false

RETmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: RET mutation
required: sms:false

SDHAF2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SDHAF2 mutation
required: sms:false

SDHBmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SDHB mutation
required: sms:false

SDHCmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SDHC mutation
required: sms:false

SDHDmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SDHD mutation
required: sms:false

SETD2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SETD2 mutation
required: sms:false

SMAD4mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SMAD4 mutation
required: sms:false

SMARCA4mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SMARCA4 mutation
required: sms:false

SMARCB1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: SMARCB1 mutation
required: sms:false

STK11mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: STK11 mutation
required: sms:false

TMEM127mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: TMEM127 mutation
required: sms:false

TP53mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: TP53 mutation
required: sms:false

TSC1mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: TSC1 mutation
required: sms:false

TSC2mutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: TSC2 mutation
required: sms:false

VHLmutation
type: Class
comment: TBD
subclass of: CancerAssociatedGeneMutations
is part of: schema.biothings.io
display name: VHL mutation
required: sms:false

UVlightinducedmutations
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: UV light induced mutations
required: sms:false

http://schema.biothings.io/AlkylatingAgents(Temozolomide)inducedmutations
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Alkylating Agents (Temozolomide) induced mutations
required: sms:false

Tobaccouseassociatedmutations
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Tobacco use associated mutations
required: sms:false

Ageofcancerdiagnosis
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: age of cancer diagnosis
required: sms:false

Transcriptionalstrandbias
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: transcriptional strand bias
required: sms:false

http://schema.biothings.io/Microsatelliteinstability(additionsanddeletions)
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: microsatellite instability (additions and deletions)
required: sms:false

http://schema.biothings.io/MethylatedCpGsequencesmutagenesis(deaminationof5-methyl-cytosine)
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: methylated CpG sequences mutagenesis(deamination of 5-methyl-cytosine)
required: sms:false

http://schema.biothings.io/ActivationInducedDeaminases(AID)associatedmutations
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Activation Induced Deaminases (AID) associated mutations
required: sms:false

APOBECenzymesassociatedmutations
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: APOBEC enzymes associated mutations
required: sms:false

Alteredactivityoftheerror-pronepolymerasePOLε(POLE)
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: altered activity of the error-prone polymerase POLε (POLE)
required: sms:false

http://schema.biothings.io/Localizedsubstitutionhypermutation(kataegis)
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: localized substitution hypermutation (kataegis)
required: sms:false

DNAMMRDeficiency
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: DNA MMR Deficiency
required: sms:false

Iggenehypermutation
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Ig gene hypermutation
required: sms:false

Signature1A
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 1A
required: sms:false

Signature1B
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 1B
required: sms:false

Signature2
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 2
required: sms:false

Signature3
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 3
required: sms:false

Signature4
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 4
required: sms:false

Signature5
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 5
required: sms:false

Signature6
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 6
required: sms:false

Signature7
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 7
required: sms:false

Signature8
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 8
required: sms:false

Signature9
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 9
required: sms:false

Signature10
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 10
required: sms:false

Signature11
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 11
required: sms:false

Signature12
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 12
required: sms:false

Signature13
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 13
required: sms:false

Signature14
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 14
required: sms:false

Signature15
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 15
required: sms:false

Signature16
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 16
required: sms:false

Signature17
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 17
required: sms:false

Signature18
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 18
required: sms:false

Signature19
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 19
required: sms:false

Signature20
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 20
required: sms:false

Signature21
type: Class
comment: TBD
subclass of: MutationalSignatures
is part of: schema.biothings.io
display name: Signature 21
required: sms:false

MismatchrepairdeficiencyMMRD
type: Class
comment: TBD
subclass of: MismatchRepairSystemStatus
is part of: schema.biothings.io
display name: Mismatch repair deficiency MMRD
required: sms:false

MismatchrepairproficiencyMMPP
type: Class
comment: TBD
subclass of: MismatchRepairSystemStatus
is part of: schema.biothings.io
display name: Mismatch repair proficiency MMPP
required: sms:false

MicrosatelliteinstabilityhighMSIH
type: Class
comment: TBD
subclass of: MismatchRepairSystemStatus
is part of: schema.biothings.io
display name: Microsatellite instability high MSIH
required: sms:false

MicrosatellitestableMSS
type: Class
comment: TBD
subclass of: MismatchRepairSystemStatus
is part of: schema.biothings.io
display name: Microsatellite stable MSS
required: sms:false

Unknownorother
type: Class
comment: TBD
subclass of: MismatchRepairSystemStatus
is part of: schema.biothings.io
display name: unknown or other
required: sms:false

IHCstainingformismatchrepairproteins
type: Class
comment: TBD
subclass of: LabTestsforMMRStatus
is part of: schema.biothings.io
display name: IHC staining for mismatch repair proteins
required: sms:false

PCRtoevaluatemicrosatelliteinstability
type: Class
comment: TBD
subclass of: LabTestsforMMRStatus
is part of: schema.biothings.io
display name: PCR to evaluate microsatellite instability
required: sms:false

MLH1 promotermethylationanalysis
type: Class
comment: TBD
subclass of: LabTestsforMMRStatus
is part of: schema.biothings.io
display name: MLH1 promoter methylation analysis
required: sms:false

BRAF sequencing
type: Class
comment: TBD
subclass of: LabTestsforMMRStatus
is part of: schema.biothings.io
display name: BRAF sequencing
required: sms:false

StandardofCareScreening
type: Class
comment: TBD
subclass of: ModeofCancerDetection
is part of: schema.biothings.io
display name: Standard of Care Screening
required: sms:false

ClinicalExaminationofunrelatedcancersymptoms
type: Class
comment: TBD
subclass of: ModeofCancerDetection
is part of: schema.biothings.io
display name: Clinical Examination of unrelated cancer symptoms
required: sms:false

Incidentaloma
type: Class
comment: TBD
subclass of: ModeofCancerDetection
is part of: schema.biothings.io
display name: Incidentaloma
required: sms:false

IntervalCancer
type: Class
comment: TBD
subclass of: ModeofCancerDetection
is part of: schema.biothings.io
display name: Interval Cancer
required: sms:false

ComparativeGenomicHybridization
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Comparative Genomic Hybridization
required: sms:false

CytogeneticsNOS
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Cytogenetics NOS
required: sms:false

FISH
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: FISH
required: sms:false

FlowCytometry
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Flow Cytometry
required: sms:false

ISH
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: ISH
required: sms:false

Karyotype
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Karyotype
required: sms:false

Microarray
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Microarray
required: sms:false

MicrosatelliteAnalysis
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Microsatellite Analysis
required: sms:false

NuclearStaining
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Nuclear Staining
required: sms:false

RNASequencing
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: RNA Sequencing
required: sms:false

SequencingNOS
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Sequencing NOS
required: sms:false

SouthernBlotting
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Southern Blotting
required: sms:false

TargetedSequencing
type: Class
comment: TBD
subclass of: MolecularAnalysisMethod
is part of: schema.biothings.io
display name: Targeted Sequencing
required: sms:false

AbnormalNOS
type: Class
comment: TBD
subclass of: TestResult
is part of: schema.biothings.io
display name: Abnormal NOS
required: sms:false

CopyNumberReported
type: Class
comment: TBD
subclass of: TestResult
is part of: schema.biothings.io
display name: Copy Number Reported
required: sms:false

Equivocal
type: Class
comment: TBD
subclass of: BreastCarcinomaEstrogenReceptorStatus
subclass of: BreastCarcinomaProgesteronerReceptorStatus
subclass of: TestResult
subclass of: AnaplasiaPresentType
subclass of: BreastCarcinomaHER2Status
is part of: schema.biothings.io
display name: Equivocal
required: sms:false

High
type: Class
comment: TBD
subclass of: MitosisKaryorrhexisIndex
subclass of: TestResult
is part of: schema.biothings.io
display name: High
required: sms:false

Intermediate
type: Class
comment: TBD
subclass of: MitosisKaryorrhexisIndex
subclass of: TestResult
is part of: schema.biothings.io
display name: Intermediate
required: sms:false

LossofExpression
type: Class
comment: TBD
subclass of: TestResult
is part of: schema.biothings.io
display name: Loss of Expression
required: sms:false

Low
type: Class
comment: TBD
subclass of: MitosisKaryorrhexisIndex
subclass of: TestResult
is part of: schema.biothings.io
display name: Low
required: sms:false

Overexpressed
type: Class
comment: TBD
subclass of: TestResult
is part of: schema.biothings.io
display name: Overexpressed
required: sms:false

TestValueReported
type: Class
comment: TBD
subclass of: TestResult
is part of: schema.biothings.io
display name: Test Value Reported
required: sms:false

BCL6
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: BCL6
required: sms:false

CA-125
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CA-125
required: sms:false

CA19-9
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CA19-9
required: sms:false

CCND1
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CCND1
required: sms:false

CD10
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD10
required: sms:false

CD117
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD117
required: sms:false

CD138
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD138
required: sms:false

CD14
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD14
required: sms:false

CD15
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD15
required: sms:false

CD19
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD19
required: sms:false

CD20
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD20
required: sms:false

CD22
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD22
required: sms:false

CD23
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD23
required: sms:false

CD25
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD25
required: sms:false

CD3
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD3
required: sms:false

CD30
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD30
required: sms:false

CD33
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD33
required: sms:false

CD34
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD34
required: sms:false

CD45
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD45
required: sms:false

CD5
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD5
required: sms:false

CD56
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD56
required: sms:false

CD7
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD7
required: sms:false

CD79A
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CD79A
required: sms:false

CEA
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: CEA
required: sms:false

HLA-DR
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: HLA-DR
required: sms:false

Mesothelin
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: Mesothelin
required: sms:false

NSE
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: NSE
required: sms:false

SquamousCellCarcinomaAntigen
type: Class
comment: TBD
subclass of: Antigen
is part of: schema.biothings.io
display name: Squamous Cell Carcinoma Antigen
required: sms:false

BuffyCoat
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Buffy Coat
required: sms:false

EmbryonicFluid
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Embryonic Fluid
required: sms:false

EmbryonicTissue
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Embryonic Tissue
required: sms:false

Feces
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Feces
required: sms:false

Granulocyte
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Granulocyte
required: sms:false

MuscleTissue
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Muscle Tissue
required: sms:false

NerveTissue
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Nerve Tissue
required: sms:false

PeritonealFluid
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Peritoneal Fluid
required: sms:false

PleuralFluid
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Pleural Fluid
required: sms:false

Saliva
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Saliva
required: sms:false

Serum
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Serum
required: sms:false

TissueNOS
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Tissue NOS
required: sms:false

UninvolvedTissueNOS
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Uninvolved Tissue NOS
required: sms:false

Urine
type: Class
comment: TBD
subclass of: ClinicalBiospecimenType
is part of: schema.biothings.io
display name: Urine
required: sms:false

Chr1
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr1
required: sms:false

Chr2
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr2
required: sms:false

Chr3
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr3
required: sms:false

Chr4
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr4
required: sms:false

Chr5
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr5
required: sms:false

Chr6
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr6
required: sms:false

Chr7
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr7
required: sms:false

Chr8
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr8
required: sms:false

Chr9
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr9
required: sms:false

Chr10
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr10
required: sms:false

Chr11
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr11
required: sms:false

Chr12
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr12
required: sms:false

Chr13
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr13
required: sms:false

Chr14
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr14
required: sms:false

Chr15
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr15
required: sms:false

Chr16
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr16
required: sms:false

Chr17
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr17
required: sms:false

Chr18
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr18
required: sms:false

Chr19
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr19
required: sms:false

Chr20
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr20
required: sms:false

Chr21
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr21
required: sms:false

Chr22
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr22
required: sms:false

Chr23
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chr23
required: sms:false

ChrM
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chrM
required: sms:false

ChrX
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chrX
required: sms:false

ChrY
type: Class
comment: TBD
subclass of: Chromosome
is part of: schema.biothings.io
display name: chrY
required: sms:false

Clonal
type: Class
comment: TBD
subclass of: Clonality
is part of: schema.biothings.io
display name: Clonal
required: sms:false

Non-clonal
type: Class
comment: TBD
subclass of: Clonality
is part of: schema.biothings.io
display name: Non-clonal
required: sms:false

H1
type: Class
comment: TBD
subclass of: HistoneFamily
is part of: schema.biothings.io
display name: H1
required: sms:false

H2A
type: Class
comment: TBD
subclass of: HistoneFamily
is part of: schema.biothings.io
display name: H2A
required: sms:false

H2B
type: Class
comment: TBD
subclass of: HistoneFamily
is part of: schema.biothings.io
display name: H2B
required: sms:false

H3
type: Class
comment: TBD
subclass of: HistoneFamily
is part of: schema.biothings.io
display name: H3
required: sms:false

H4
type: Class
comment: TBD
subclass of: HistoneFamily
is part of: schema.biothings.io
display name: H4
required: sms:false

CENP-A
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: CENP-A
required: sms:false

H2A-Bbd
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A-Bbd
required: sms:false

H2A.X
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A.X
required: sms:false

H2A.Z
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A.Z
required: sms:false

H2A.Z.1
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A.Z.1
required: sms:false

H2A.Z.2
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A.Z.2
required: sms:false

H2A.Z.2.2
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H2A.Z.2.2
required: sms:false

H3.1
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.1
required: sms:false

H3.2
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.2
required: sms:false

H3.3
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.3
required: sms:false

H3.5
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.5
required: sms:false

H3.X
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.X
required: sms:false

H3.Y
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3.Y
required: sms:false

H3t(H3.4)
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: H3t (H3.4)
required: sms:false

MH2A
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: mH2A
required: sms:false

MH2A.1
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: mH2A.1
required: sms:false

MH2A.2
type: Class
comment: TBD
subclass of: HistoneVariant
is part of: schema.biothings.io
display name: mH2A.2
required: sms:false

AbsoluteNeutrophil
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Absolute Neutrophil
required: sms:false

Albumin
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Albumin
required: sms:false

AlphaFetoprotein
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Alpha Fetoprotein
required: sms:false

B-cellgenotyping
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: B-cell genotyping
required: sms:false

Basophil
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Basophil
required: sms:false

Beta2Microglobulin
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Beta 2 Microglobulin
required: sms:false

BloodUreaNitrogen
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Blood Urea Nitrogen
required: sms:false

C-ReactiveProtein
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: C-Reactive Protein
required: sms:false

Calcium
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Calcium
required: sms:false

Cellularity
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Cellularity
required: sms:false

CirculatingTumorCells
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Circulating Tumor Cells
required: sms:false

Creatinine
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Creatinine
required: sms:false

Eosinophil
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Eosinophil
required: sms:false

Glucose
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Glucose
required: sms:false

Hematocrit
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Hematocrit
required: sms:false

Hemoglobin
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Hemoglobin
required: sms:false

HPV-E6/E7
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: HPV-E6/E7
required: sms:false

HumanChorionicGonadotropin
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Human Chorionic Gonadotropin
required: sms:false

HumanPapillomavirus
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Human Papillomavirus
required: sms:false

ImmunoglobulinA
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Immunoglobulin A
required: sms:false

ImmunoglobulinG
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Immunoglobulin G
required: sms:false

ImmunoglobulinM
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Immunoglobulin M
required: sms:false

LactateDehydrogenase
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Lactate Dehydrogenase
required: sms:false

Leukocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Leukocytes
required: sms:false

LuteinizingHormone
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Luteinizing Hormone
required: sms:false

Lymphoblasts
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Lymphoblasts
required: sms:false

Lymphocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Lymphocytes
required: sms:false

MProtein
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: M Protein
required: sms:false

Metamyelocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Metamyelocytes
required: sms:false

Myeloblasts
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Myeloblasts
required: sms:false

Myelocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Myelocytes
required: sms:false

NeutrophilBands
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Neutrophil Bands
required: sms:false

Platelets
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Platelets
required: sms:false

Prolymphocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Prolymphocytes
required: sms:false

Promonocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Promonocytes
required: sms:false

Promyelocytes
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Promyelocytes
required: sms:false

SegmentedNeutrophil
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Segmented Neutrophil
required: sms:false

SerumFreeImmunoglobulinLightChain
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Serum Free Immunoglobulin Light Chain
required: sms:false

Kappa
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Kappa
required: sms:false

Lambda
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Lambda
required: sms:false

Testosterone
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Testosterone
required: sms:false

TotalBilirubin
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Total Bilirubin
required: sms:false

TotalProtein
type: Class
comment: TBD
subclass of: LaboratoryTest
is part of: schema.biothings.io
display name: Total Protein
required: sms:false

3PrimeUTRVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: 3 Prime UTR Variant
required: sms:false

5PrimeUTRVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: 5 Prime UTR Variant
required: sms:false

CodingSequenceVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Coding Sequence Variant
required: sms:false

DownstreamGeneVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Downstream Gene Variant
required: sms:false

FeatureElongation
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Feature Elongation
required: sms:false

FeatureTruncation
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Feature Truncation
required: sms:false

FrameshiftVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Frameshift Variant
required: sms:false

IncompleteTerminalCodonVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Incomplete Terminal Codon Variant
required: sms:false

InframeDeletion
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Inframe Deletion
required: sms:false

InframeInsertion
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Inframe Insertion
required: sms:false

IntergenicVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Intergenic Variant
required: sms:false

IntronVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Intron Variant
required: sms:false

MaturemiRNAVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Mature miRNA Variant
required: sms:false

MissenseVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Missense Variant
required: sms:false

NMDTranscriptVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: NMD Transcript Variant
required: sms:false

Non-codingTranscriptExonVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Non-coding Transcript Exon Variant
required: sms:false

Non-codingTranscriptVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Non-coding Transcript Variant
required: sms:false

ProteinAlteringVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Protein Altering Variant
required: sms:false

RegulatoryRegionAblation
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Regulatory Region Ablation
required: sms:false

RegulatoryRegionAmplification
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Regulatory Region Amplification
required: sms:false

RegulatoryRegionVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Regulatory Region Variant
required: sms:false

SpliceAcceptorVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Splice Acceptor Variant
required: sms:false

SpliceDonorVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Splice Donor Variant
required: sms:false

SpliceRegionVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Splice Region Variant
required: sms:false

StartLost
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Start Lost
required: sms:false

StopGain
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Stop Gain
required: sms:false

StopLost
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Stop Lost
required: sms:false

StopRetainedVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Stop Retained Variant
required: sms:false

SynonymousVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Synonymous Variant
required: sms:false

TFBindingSiteVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: TF Binding Site Variant
required: sms:false

TFBSAblation
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: TFBS Ablation
required: sms:false

TFBSAmplification
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: TFBS Amplification
required: sms:false

TranscriptAblation
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Transcript Ablation
required: sms:false

TranscriptAmplification
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Transcript Amplification
required: sms:false

UpstreamGeneVariant
type: Class
comment: TBD
subclass of: MolecularConsequence
is part of: schema.biothings.io
display name: Upstream Gene Variant
required: sms:false

Benign
type: Class
comment: TBD
subclass of: Pathogenicity
is part of: schema.biothings.io
display name: Benign
required: sms:false

LikelyBenign
type: Class
comment: TBD
subclass of: Pathogenicity
is part of: schema.biothings.io
display name: Likely Benign
required: sms:false

LikelyPathogenic
type: Class
comment: TBD
subclass of: Pathogenicity
is part of: schema.biothings.io
display name: Likely Pathogenic
required: sms:false

Pathogenic
type: Class
comment: TBD
subclass of: Pathogenicity
is part of: schema.biothings.io
display name: Pathogenic
required: sms:false

UncertainSignificance
type: Class
comment: TBD
subclass of: Pathogenicity
is part of: schema.biothings.io
display name: Uncertain Significance
required: sms:false

Aneuploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Aneuploid
required: sms:false

Diploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Diploid
required: sms:false

Hyperdiploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Hyperdiploid
required: sms:false

Hypodiploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Hypodiploid
required: sms:false

NearDiploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Near Diploid
required: sms:false

Tetraploid
type: Class
comment: TBD
subclass of: Ploidy
is part of: schema.biothings.io
display name: Tetraploid
required: sms:false

DNA
type: Class
comment: TBD
subclass of: TestAnalyteType
subclass of: MicroarrayMolecule
is part of: schema.biothings.io
display name: DNA
required: sms:false

MRNA
type: Class
comment: TBD
subclass of: TestAnalyteType
is part of: schema.biothings.io
display name: mRNA
required: sms:false

MiRNA
type: Class
comment: TBD
subclass of: TestAnalyteType
is part of: schema.biothings.io
display name: miRNA
required: sms:false

ProteinAnalyte
type: Class
comment: TBD
subclass of: TestAnalyteType
is part of: schema.biothings.io
display name: Protein Analyte
required: sms:false

TotalRNA
type: Class
comment: TBD
subclass of: TestAnalyteType
is part of: schema.biothings.io
display name: Total RNA
required: sms:false

Germline
type: Class
comment: TBD
subclass of: VariantOrigin
is part of: schema.biothings.io
display name: Germline
required: sms:false

Somatic
type: Class
comment: TBD
subclass of: VariantOrigin
is part of: schema.biothings.io
display name: Somatic
required: sms:false

Alleles
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Alleles
required: sms:false

Amplification
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Amplification
required: sms:false

Chrimerism
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Chrimerism
required: sms:false

Conversion
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Conversion
required: sms:false

Deletion
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Deletion
required: sms:false

Deletion-Insertion
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Deletion-Insertion
required: sms:false

Duplication
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Duplication
required: sms:false

Extension
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Extension
required: sms:false

Gain
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Gain
required: sms:false

Hypermethylation
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Hypermethylation
required: sms:false

Insertion
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Insertion
required: sms:false

Inversion
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Inversion
required: sms:false

Loss
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Loss
required: sms:false

Methylation
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Methylation
required: sms:false

Mosaicism
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Mosaicism
required: sms:false

PartialMethylation
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Partial Methylation
required: sms:false

Rearrangement
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Rearrangement
required: sms:false

RepeatedSequences
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Repeated Sequences
required: sms:false

Splice
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Splice
required: sms:false

Substitution
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Substitution
required: sms:false

Translocation
type: Class
comment: TBD
subclass of: VariantType
is part of: schema.biothings.io
display name: Translocation
required: sms:false

Heterozygous
type: Class
comment: TBD
subclass of: Zygosity
is part of: schema.biothings.io
display name: Heterozygous
required: sms:false

Hemizygous
type: Class
comment: TBD
subclass of: Zygosity
is part of: schema.biothings.io
display name: Hemizygous
required: sms:false

Homozygous
type: Class
comment: TBD
subclass of: Zygosity
is part of: schema.biothings.io
display name: Homozygous
required: sms:false

Nullizygous
type: Class
comment: TBD
subclass of: Zygosity
is part of: schema.biothings.io
display name: Nullizygous
required: sms:false

HighRisk
type: Class
comment: TBD
subclass of: CogNeuroblastomaRiskGroup
subclass of: CogRhabdomyosarcomaRiskGroup
subclass of: InternationalPrognosticIndex
is part of: schema.biothings.io
display name: High Risk
required: sms:false

IntermediateRisk
type: Class
comment: TBD
subclass of: CogNeuroblastomaRiskGroup
subclass of: CogRhabdomyosarcomaRiskGroup
is part of: schema.biothings.io
display name: Intermediate Risk
required: sms:false

LowRisk
type: Class
comment: TBD
subclass of: InternationalPrognosticIndex
subclass of: CogNeuroblastomaRiskGroup
subclass of: CogRhabdomyosarcomaRiskGroup
is part of: schema.biothings.io
display name: Low Risk
required: sms:false

Group1
type: Class
comment: TBD
subclass of: GleasonGradeGroup
is part of: schema.biothings.io
display name: Group 1
required: sms:false

Group2
type: Class
comment: TBD
subclass of: GleasonGradeGroup
is part of: schema.biothings.io
display name: Group 2
required: sms:false

Group3
type: Class
comment: TBD
subclass of: GleasonGradeGroup
is part of: schema.biothings.io
display name: Group 3
required: sms:false

Group4
type: Class
comment: TBD
subclass of: GleasonGradeGroup
is part of: schema.biothings.io
display name: Group 4
required: sms:false

Group5
type: Class
comment: TBD
subclass of: GleasonGradeGroup
is part of: schema.biothings.io
display name: Group 5
required: sms:false

Pattern4
type: Class
comment: TBD
subclass of: GleasonGradeTertiary
subclass of: PrimaryGleasonGrade
subclass of: SecondaryGleasonGrade
is part of: schema.biothings.io
display name: Pattern 4
required: sms:false

Pattern5
type: Class
comment: TBD
subclass of: GleasonGradeTertiary
subclass of: PrimaryGleasonGrade
subclass of: SecondaryGleasonGrade
is part of: schema.biothings.io
display name: Pattern 5
required: sms:false

GoodPrognosis
type: Class
comment: TBD
subclass of: IGCCCGStage
is part of: schema.biothings.io
display name: Good Prognosis
required: sms:false

IntermediatePrognosis
type: Class
comment: TBD
subclass of: IGCCCGStage
is part of: schema.biothings.io
display name: Intermediate Prognosis
required: sms:false

PoorPrognosis
type: Class
comment: TBD
subclass of: IGCCCGStage
is part of: schema.biothings.io
display name: Poor Prognosis
required: sms:false

Differentiating
type: Class
comment: TBD
subclass of: INPCGrade
is part of: schema.biothings.io
display name: Differentiating
required: sms:false

PoorlyDifferentiated
type: Class
comment: TBD
subclass of: INPCGrade
is part of: schema.biothings.io
display name: Poorly Differentiated
required: sms:false

Undifferentiated
type: Class
comment: TBD
subclass of: INPCGrade
is part of: schema.biothings.io
display name: Undifferentiated
required: sms:false

Favorable
type: Class
comment: TBD
subclass of: INPCHistologicGroup
is part of: schema.biothings.io
display name: Favorable
required: sms:false

Unfavorable
type: Class
comment: TBD
subclass of: INPCHistologicGroup
is part of: schema.biothings.io
display name: Unfavorable
required: sms:false

L1
type: Class
comment: TBD
subclass of: INRGStage
is part of: schema.biothings.io
display name: L1
required: sms:false

L2
type: Class
comment: TBD
subclass of: INRGStage
is part of: schema.biothings.io
display name: L2
required: sms:false

Ms
type: Class
comment: TBD
subclass of: INRGStage
is part of: schema.biothings.io
display name: Ms
required: sms:false

Stage1
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 1
required: sms:false

Stage2A
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 2A
required: sms:false

Stage2B
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 2B
required: sms:false

Stage3
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 3
required: sms:false

Stage4
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 4
required: sms:false

Stage4S
type: Class
comment: TBD
subclass of: INSSStage
is part of: schema.biothings.io
display name: Stage 4S
required: sms:false

Low-IntermediateRisk
type: Class
comment: TBD
subclass of: InternationalPrognosticIndex
is part of: schema.biothings.io
display name: Low-Intermediate Risk
required: sms:false

High-IntermediateRisk
type: Class
comment: TBD
subclass of: InternationalPrognosticIndex
is part of: schema.biothings.io
display name: High-Intermediate Risk
required: sms:false

GroupI
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group I
required: sms:false

GroupIa
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group Ia
required: sms:false

GroupIb
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group Ib
required: sms:false

GroupII
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group II
required: sms:false

GroupIIa
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group IIa
required: sms:false

GroupIIc
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group IIc
required: sms:false

GroupIII
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group III
required: sms:false

GroupIIIa
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group IIIa
required: sms:false

GroupIIIb
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group IIIb
required: sms:false

GroupIV
type: Class
comment: TBD
subclass of: IRSGroup
is part of: schema.biothings.io
display name: Group IV
required: sms:false

1
type: Class
comment: TBD
subclass of: IRSStage
subclass of: BreastCancerAllredEstrogenReceptorScore
is part of: schema.biothings.io
display name: 1
required: sms:false

2
type: Class
comment: TBD
subclass of: IRSStage
subclass of: BreastCancerAllredEstrogenReceptorScore
is part of: schema.biothings.io
display name: 2
required: sms:false

3
type: Class
comment: TBD
subclass of: IRSStage
subclass of: BreastCancerAllredEstrogenReceptorScore
is part of: schema.biothings.io
display name: 3
required: sms:false

4
type: Class
comment: TBD
subclass of: IRSStage
subclass of: BreastCancerAllredEstrogenReceptorScore
is part of: schema.biothings.io
display name: 4
required: sms:false

II
type: Class
comment: TBD
subclass of: ISSStage
subclass of: MelanomaSpecimenClarkLevelValue
subclass of: FitzpatrickSkinTone
is part of: schema.biothings.io
display name: II
required: sms:false

III
type: Class
comment: TBD
subclass of: ISSStage
subclass of: MelanomaSpecimenClarkLevelValue
subclass of: FitzpatrickSkinTone
is part of: schema.biothings.io
display name: III
required: sms:false

Axillary
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
subclass of: MetastasisatDiagnosisSite
is part of: schema.biothings.io
display name: Axillary
required: sms:false

Cervical
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Cervical
required: sms:false

Femoral
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Femoral
required: sms:false

Iliac-common
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Iliac-common
required: sms:false

Iliac-external
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Iliac-external
required: sms:false

Iliac
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Iliac
required: sms:false

Inguinal
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
subclass of: MetastasisatDiagnosisSite
is part of: schema.biothings.io
display name: Inguinal
required: sms:false

Mediastinal
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Mediastinal
required: sms:false

Mesenteric
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Mesenteric
required: sms:false

Occipital
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Occipital
required: sms:false

Paraaortic
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Paraaortic
required: sms:false

Parotid
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Parotid
required: sms:false

Popliteal
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Popliteal
required: sms:false

Retroperitoneal
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Retroperitoneal
required: sms:false

Splenic
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Splenic
required: sms:false

Submandibular
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Submandibular
required: sms:false

Supraclavicular
type: Class
comment: TBD
subclass of: LymphNodeInvolvedSite
is part of: schema.biothings.io
display name: Supraclavicular
required: sms:false

GerotaFascia
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Gerota Fascia
required: sms:false

Parenchyma
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Parenchyma
required: sms:false

PerinephricFat
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Perinephric Fat
required: sms:false

Renal
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Renal
required: sms:false

RenalCapsule
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Renal Capsule
required: sms:false

RenalSinus
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Renal Sinus
required: sms:false

RenalVein
type: Class
comment: TBD
subclass of: MarginsInvolvedSite
is part of: schema.biothings.io
display name: Renal Vein
required: sms:false

NotDetermined
type: Class
comment: TBD
subclass of: MedulloblastomaMolecularClassification
is part of: schema.biothings.io
display name: Not Determined
required: sms:false

Non-WNT/non-SHHActivated
type: Class
comment: TBD
subclass of: MedulloblastomaMolecularClassification
is part of: schema.biothings.io
display name: Non-WNT/non-SHH Activated
required: sms:false

SHH-Activated
type: Class
comment: TBD
subclass of: MedulloblastomaMolecularClassification
is part of: schema.biothings.io
display name: SHH-Activated
required: sms:false

WNT-Activated
type: Class
comment: TBD
subclass of: MedulloblastomaMolecularClassification
is part of: schema.biothings.io
display name: WNT-Activated
required: sms:false

OvarianCapsuleIntact
type: Class
comment: TBD
subclass of: OvarianSpecimenStatus
is part of: schema.biothings.io
display name: Ovarian Capsule Intact
required: sms:false

OvarianCapsuleRuptured
type: Class
comment: TBD
subclass of: OvarianSpecimenStatus
is part of: schema.biothings.io
display name: Ovarian Capsule Ruptured
required: sms:false

OvarianCapsuleFragmented
type: Class
comment: TBD
subclass of: OvarianSpecimenStatus
is part of: schema.biothings.io
display name: Ovarian Capsule Fragmented
required: sms:false

Pattern1
type: Class
comment: TBD
subclass of: PrimaryGleasonGrade
subclass of: SecondaryGleasonGrade
is part of: schema.biothings.io
display name: Pattern 1
required: sms:false

Pattern2
type: Class
comment: TBD
subclass of: PrimaryGleasonGrade
subclass of: SecondaryGleasonGrade
is part of: schema.biothings.io
display name: Pattern 2
required: sms:false

Pattern3
type: Class
comment: TBD
subclass of: PrimaryGleasonGrade
subclass of: SecondaryGleasonGrade
is part of: schema.biothings.io
display name: Pattern 3
required: sms:false

DeepGray
type: Class
comment: TBD
subclass of: SupratentorialLocalization
is part of: schema.biothings.io
display name: Deep Gray
required: sms:false

WhiteMatter
type: Class
comment: TBD
subclass of: SupratentorialLocalization
is part of: schema.biothings.io
display name: White Matter
required: sms:false

GradeI
type: Class
comment: TBD
subclass of: WHOCNSGrade
is part of: schema.biothings.io
display name: Grade I
required: sms:false

GradeII
type: Class
comment: TBD
subclass of: WHOCNSGrade
is part of: schema.biothings.io
display name: Grade II
required: sms:false

GradeIII
type: Class
comment: TBD
subclass of: WHOCNSGrade
is part of: schema.biothings.io
display name: Grade III
required: sms:false

GradeIV
type: Class
comment: TBD
subclass of: WHOCNSGrade
is part of: schema.biothings.io
display name: Grade IV
required: sms:false

GradeNotAssigned
type: Class
comment: TBD
subclass of: WHOCNSGrade
is part of: schema.biothings.io
display name: Grade Not Assigned
required: sms:false

G1
type: Class
comment: TBD
subclass of: WHONTEGrade
subclass of: TumorGrade
is part of: schema.biothings.io
display name: G1
required: sms:false

G2
type: Class
comment: TBD
subclass of: WHONTEGrade
subclass of: TumorGrade
is part of: schema.biothings.io
display name: G2
required: sms:false

G3
type: Class
comment: TBD
subclass of: WHONTEGrade
subclass of: TumorGrade
is part of: schema.biothings.io
display name: G3
required: sms:false

GX
type: Class
comment: TBD
subclass of: WHONTEGrade
subclass of: TumorGrade
is part of: schema.biothings.io
display name: GX
required: sms:false

Distantmetrecurrence/progression
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: Distant met recurrence/progression
required: sms:false

Loco-regionalrecurrence/progression
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: Loco-regional recurrence/progression
required: sms:false

Biochemicalevidenceofdiseasewithoutstructuralcorrelate
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: Biochemical evidence of disease without structural correlate
required: sms:false

Tumorfree
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: Tumor free
required: sms:false

Unknowntumorstatus
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: unknown tumor status
required: sms:false

Withtumor
type: Class
comment: TBD
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: With tumor
required: sms:false

NotAllowedToCollect
type: Class
comment: TBD
subclass of: PriorMalignancy
subclass of: PriorTreatment
subclass of: VascularInvasionPresent
subclass of: ClassificationofTumor
subclass of: LastKnownDiseaseStatus
is part of: schema.biothings.io
display name: Not Allowed To Collect
required: sms:false

Acinarcellcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acinar cell carcinoma
required: sms:false

Acutebasophilicleukaemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute basophilic leukaemia
required: sms:false

AcuteleukemiaBurkitttype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute leukemia Burkitt type
required: sms:false

AcuteleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute leukemia NOS
required: sms:false

Acutelymphaticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphatic leukemia
required: sms:false

Acutelymphoblasticleukemia-lymphomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphoblastic leukemia-lymphoma NOS
required: sms:false

AcutelymphoblasticleukemiamatureB-celltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphoblastic leukemia mature B-cell type
required: sms:false

AcutelymphoblasticleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphoblastic leukemia NOS
required: sms:false

Acutelymphoblasticleukemiaprecursorcelltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphoblastic leukemia precursor cell type
required: sms:false

Acutelymphocyticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphocytic leukemia
required: sms:false

Acutelymphoidleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute lymphoid leukemia
required: sms:false

Acutemyeloidleukemiaminimaldifferentiation
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute myeloid leukemia minimal differentiation
required: sms:false

AcutemyeloidleukemiaMLL
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute myeloid leukemia MLL
required: sms:false

AcutemyeloidleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute myeloid leukemia NOS
required: sms:false

Acutemyelomonocyticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute myelomonocytic leukemia
required: sms:false

AcutepromyelocyticleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Acute promyelocytic leukemia NOS
required: sms:false

Adenocarcinoidtumor
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoid tumor
required: sms:false

Adenocarcinomacombinedwithothertypesofcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma combined with other types of carcinoma
required: sms:false

AdenocarcinomainapolypNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in a polyp NOS
required: sms:false

Adenocarcinomainadenomatouspolyp
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in adenomatous polyp
required: sms:false

Adenocarcinomainpolypoidadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in polypoid adenoma
required: sms:false

AdenocarcinomainsituinapolypNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ in a polyp NOS
required: sms:false

Adenocarcinomainsituinadenomatouspolyp
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ in adenomatous polyp
required: sms:false

Adenocarcinomainsituintubularadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ in tubular adenoma
required: sms:false

Adenocarcinomainsitumucinous
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ mucinous
required: sms:false

Adenocarcinomainsitunon-mucinous
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ non-mucinous
required: sms:false

AdenocarcinomainsituNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in situ NOS
required: sms:false

Adenocarcinomaintubularadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in tubular adenoma
required: sms:false

Adenocarcinomainvillousadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma in villous adenoma
required: sms:false

Adenocarcinomaofanalducts
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma of anal ducts
required: sms:false

Adenocarcinomaofanalglands
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma of anal glands
required: sms:false

Adenocarcinomadiffusetype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma diffuse type
required: sms:false

Adenocarcinomaendocervicaltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma endocervical type
required: sms:false

Adenocarcinomaintestinaltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma intestinal type
required: sms:false

AdenocarcinomametastaticNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma metastatic NOS
required: sms:false

AdenocarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma NOS
required: sms:false

Adenocarcinomapancreatobiliarytype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adenocarcinoma pancreatobiliary type
required: sms:false

Adultrhabdomyoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adult rhabdomyoma
required: sms:false

AdultT-celllymphoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adult T-cell lymphoma
required: sms:false

AdultT-celllymphoma/leukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Adult T-cell lymphoma/leukemia
required: sms:false

Astrocytomaanaplastic
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Astrocytoma anaplastic
required: sms:false

Astrocytomalowgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Astrocytoma low grade
required: sms:false

AstrocytomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Astrocytoma NOS
required: sms:false

BcelllymphomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B cell lymphoma NOS
required: sms:false

Blymphoblasticleukemia/lymphomawithhyperdiploidy
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B lymphoblastic leukemia/lymphoma with hyperdiploidy
required: sms:false

http://schema.biothings.io/Blymphoblasticleukemia/lymphomawithhypodiploidy(HypodiploidALL)
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL)
required: sms:false

Blymphoblasticleukemia/lymphomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B lymphoblastic leukemia/lymphoma NOS
required: sms:false

B-ALL
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B-ALL
required: sms:false

B-celllymphocyticleukemia/smalllymphocyticlymphoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: B-cell lymphocytic leukemia/small lymphocytic lymphoma
required: sms:false

Basalcelladenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal cell adenocarcinoma
required: sms:false

Basalcelladenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal cell adenoma
required: sms:false

BasalcellcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal cell carcinoma NOS
required: sms:false

Basalcellepithelioma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal cell epithelioma
required: sms:false

Basalcelltumor
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basal cell tumor
required: sms:false

Basophiladenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basophil adenocarcinoma
required: sms:false

Basophiladenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basophil adenoma
required: sms:false

Basophilcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Basophil carcinoma
required: sms:false

Bileductadenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile duct adenocarcinoma
required: sms:false

Bileductadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile duct adenoma
required: sms:false

Bileductcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile duct carcinoma
required: sms:false

Bileductcystadenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile duct cystadenocarcinoma
required: sms:false

Bileductcystadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bile duct cystadenoma
required: sms:false

Bronchialadenomacarcinoid
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchial adenoma carcinoid
required: sms:false

Bronchialadenomacylindroid
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchial adenoma cylindroid
required: sms:false

BronchialadenomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchial adenoma NOS
required: sms:false

Bronchial-associatedlymphoidtissuelymphoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchial-associated lymphoid tissue lymphoma
required: sms:false

Bronchio-alveolarcarcinomamixedmucinousandnon-mucinous
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchio-alveolar carcinoma mixed mucinous and non-mucinous
required: sms:false

Bronchio-alveolarcarcinomamucinous
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchio-alveolar carcinoma mucinous
required: sms:false

Bronchiolaradenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolar adenocarcinoma
required: sms:false

Bronchiolarcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolar carcinoma
required: sms:false

Bronchiolo-alveolaradenocarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar adenocarcinoma NOS
required: sms:false

Bronchiolo-alveolarcarcinomaClaracell
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma Clara cell
required: sms:false

Bronchiolo-alveolarcarcinomaClaracellandgobletcelltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma Clara cell and goblet cell type
required: sms:false

Bronchiolo-alveolarcarcinomagobletcelltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma goblet cell type
required: sms:false

Bronchiolo-alveolarcarcinomaindeterminatetype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma indeterminate type
required: sms:false

Bronchiolo-alveolarcarcinomanon-mucinous
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma non-mucinous
required: sms:false

Bronchiolo-alveolarcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Bronchiolo-alveolar carcinoma NOS
required: sms:false

Burkittcellleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Burkitt cell leukemia
required: sms:false

BurkittlymphomaNOS(Includesallvariants)
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Burkitt lymphoma NOS (Includes all variants)
required: sms:false

Burkitttumor
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Burkitt tumor
required: sms:false

Burkitt-likelymphoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Burkitt-like lymphoma
required: sms:false

C-ALL
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: c-ALL
required: sms:false

Capillaryhemangioma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Capillary hemangioma
required: sms:false

Capillarylymphangioma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Capillary lymphangioma
required: sms:false

CarcinomainapolypNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in a polyp NOS
required: sms:false

Carcinomainadenomatouspolyp
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in adenomatous polyp
required: sms:false

Carcinomainpleomorphicadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in pleomorphic adenoma
required: sms:false

CarcinomainsituinapolypNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in situ in a polyp NOS
required: sms:false

Carcinomainsituinadenomatouspolyp
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in situ in adenomatous polyp
required: sms:false

CarcinomainsituNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma in situ NOS
required: sms:false

CarcinomaanaplasticNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma anaplastic NOS
required: sms:false

Carcinomadiffusetype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma diffuse type
required: sms:false

Carcinomaintestinaltype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma intestinal type
required: sms:false

CarcinomametastaticNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma metastatic NOS
required: sms:false

CarcinosarcomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinosarcoma NOS
required: sms:false

CarcinomaundifferentiatedNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Carcinoma undifferentiated NOS
required: sms:false

CementomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cementoma NOS
required: sms:false

Centralneuroblastoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Central neuroblastoma
required: sms:false

Centralneurocytoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Central neurocytoma
required: sms:false

Cerebellarliponeurocytoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cerebellar liponeurocytoma
required: sms:false

CerebellarsarcomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cerebellar sarcoma NOS
required: sms:false

CervicalintraepithelialneoplasiagradeIII
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cervical intraepithelial neoplasia grade III
required: sms:false

Cervicalintraepithelialneoplasialowgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Cervical intraepithelial neoplasia low grade
required: sms:false

ChondromaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chondroma NOS
required: sms:false

Chondrosarcomagrade2/3
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chondrosarcoma grade 2/3
required: sms:false

ChronicgranulocyticleukemiaBCR/ABL
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic granulocytic leukemia BCR/ABL
required: sms:false

ChronicgranulocyticleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic granulocytic leukemia NOS
required: sms:false

http://schema.biothings.io/ChronicgranulocyticleukemiaPhiladelphiachromosome(Ph1)positive
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic granulocytic leukemia Philadelphia chromosome (Ph1) positive
required: sms:false

ChronicleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic leukemia NOS
required: sms:false

Chroniclymphaticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic lymphatic leukemia
required: sms:false

Chroniclymphocyticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic lymphocytic leukemia
required: sms:false

ChroniclymphocyticleukemiaB-celltype(includesallvariantsofBCLL)
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic lymphocytic leukemia B-cell type (includes all variants of BCLL)
required: sms:false

Chroniclymphoidleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic lymphoid leukemia
required: sms:false

Chronicmonocyticleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic monocytic leukemia
required: sms:false

ChronicmyelocyticleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelocytic leukemia NOS
required: sms:false

ChronicmyelogenousleukemiaBCR-ABLpositive
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelogenous leukemia BCR-ABL positive
required: sms:false

http://schema.biothings.io/ChronicmyelogenousleukemiaPhiladelphiachromosome(Ph1)positive
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelogenous leukemia Philadelphia chromosome (Ph 1) positive
required: sms:false

ChronicmyeloidleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myeloid leukemia NOS
required: sms:false

Chronicmyelomonocyticleukemiaintransformation
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelomonocytic leukemia in transformation
required: sms:false

ChronicmyelomonocyticleukemiaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelomonocytic leukemia NOS
required: sms:false

ChronicmyelomonocyticleukemiaType1
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelomonocytic leukemia Type 1
required: sms:false

ChronicmyelomonocyticleukemiaTypeII
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myelomonocytic leukemia Type II
required: sms:false

ChronicmyeloproliferativediseaseNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myeloproliferative disease NOS
required: sms:false

Chronicmyeloproliferativedisorder
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic myeloproliferative disorder
required: sms:false

Chronicneutrophilicleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Chronic neutrophilic leukemia
required: sms:false

ClassicalHodgkinlymphomalymphocytedepletiondiffusefibrosis
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma lymphocyte depletion diffuse fibrosis
required: sms:false

ClassicalHodgkinlymphomalymphocytedepletionNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma lymphocyte depletion NOS
required: sms:false

ClassicalHodgkinlymphomalymphocytedepletionreticular
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma lymphocyte depletion reticular
required: sms:false

ClassicalHodgkinlymphomalymphocyte-rich
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma lymphocyte-rich
required: sms:false

ClassicalHodgkinlymphomamixedcellularityNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma mixed cellularity NOS
required: sms:false

ClassicalHodgkinlymphomanodularsclerosiscellularphase
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma nodular sclerosis cellular phase
required: sms:false

http://schema.biothings.io/ClassicalHodgkinlymphomanodularsclerosisgrade1
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma nodular sclerosis grade 1
required: sms:false

http://schema.biothings.io/ClassicalHodgkinlymphomanodularsclerosisgrade2
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma nodular sclerosis grade 2
required: sms:false

ClassicalHodgkinlymphomanodularsclerosisNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Classical Hodgkin lymphoma nodular sclerosis NOS
required: sms:false

Combinedhepatocellularcarcinomaandcholangiocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined hepatocellular carcinoma and cholangiocarcinoma
required: sms:false

Combinedlargecellneuroendocrinecarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined large cell neuroendocrine carcinoma
required: sms:false

Combinedsmallcellcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined small cell carcinoma
required: sms:false

Combinedsmallcell-adenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined small cell-adenocarcinoma
required: sms:false

Combinedsmallcell-largecarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined small cell-large carcinoma
required: sms:false

Combinedsmallcell-squamouscellcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined small cell-squamous cell carcinoma
required: sms:false

Combined/mixedcarcinoidandadenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Combined/mixed carcinoid and adenocarcinoma
required: sms:false

CompositeHodgkinandnon-Hodgkinlymphoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Composite Hodgkin and non-Hodgkin lymphoma
required: sms:false

Dermalnevus
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Dermal nevus
required: sms:false

DermatofibromaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Dermatofibroma NOS
required: sms:false

DiffuseastrocytomaIDH-mutant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Diffuse astrocytoma IDH-mutant
required: sms:false

DiffuseastrocytomaIDH-wildtype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Diffuse astrocytoma IDH-wildtype
required: sms:false

Diffuseastrocytomalowgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Diffuse astrocytoma low grade
required: sms:false

DiffuselargeB-celllymphomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Diffuse large B-cell lymphoma NOS
required: sms:false

Diffusemelanocytosis
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Diffuse melanocytosis
required: sms:false

DuctadenocarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Duct adenocarcinoma NOS
required: sms:false

DuctadenomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Duct adenoma NOS
required: sms:false

Ductcarcinomadesmoplastictype
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Duct carcinoma desmoplastic type
required: sms:false

DuctcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Duct carcinoma NOS
required: sms:false

Ductcellcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Duct cell carcinoma
required: sms:false

DuctalcarcinomainsituNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Ductal carcinoma in situ NOS
required: sms:false

DuctalcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Ductal carcinoma NOS
required: sms:false

Dysplasticnevus
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Dysplastic nevus
required: sms:false

EndometrialsarcomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Endometrial sarcoma NOS
required: sms:false

EndometrioidadenocarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Endometrioid adenocarcinoma NOS
required: sms:false

EndometrioidadenofibromaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Endometrioid adenofibroma NOS
required: sms:false

EndometrioidadenomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Endometrioid adenoma NOS
required: sms:false

EndometrioidcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Endometrioid carcinoma NOS
required: sms:false

Eosinophiladenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Eosinophil adenocarcinoma
required: sms:false

Eosinophiladenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Eosinophil adenoma
required: sms:false

Eosinophilcarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Eosinophil carcinoma
required: sms:false

Eosinophilicgranuloma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Eosinophilic granuloma
required: sms:false

Eosinophilicleukemia
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Eosinophilic leukemia
required: sms:false

EpendymomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Ependymoma NOS
required: sms:false

EpidermoidcarcinomainsituNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Epidermoid carcinoma in situ NOS
required: sms:false

EpidermoidcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Epidermoid carcinoma NOS
required: sms:false

Epithelialtumorbenign
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Epithelial tumor benign
required: sms:false

Epithelialtumormalignant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Epithelial tumor malignant
required: sms:false

http://schema.biothings.io/Esophagealglandulardysplasia(intraepithelialneoplasia)highgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal glandular dysplasia (intraepithelial neoplasia) high grade
required: sms:false

http://schema.biothings.io/Esophagealglandulardysplasia(intraepithelialneoplasia)lowgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal glandular dysplasia (intraepithelial neoplasia) low grade
required: sms:false

Esophagealintraepithelialneoplasiahighgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal intraepithelial neoplasia high grade
required: sms:false

http://schema.biothings.io/Esophagealsquamousintraepithelialneoplasia(dysplasia)highgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal squamous intraepithelial neoplasia (dysplasia) high grade
required: sms:false

http://schema.biothings.io/Esophagealsquamousintraepithelialneoplasia(dysplasia)lowgrade
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Esophageal squamous intraepithelial neoplasia (dysplasia) low grade
required: sms:false

Ewingsarcoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Ewing sarcoma
required: sms:false

GangliogliomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Ganglioglioma NOS
required: sms:false

Gastrincelltumor
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastrin cell tumor
required: sms:false

Gastrincelltumormalignant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastrin cell tumor malignant
required: sms:false

Gastrinomamalignant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastrinoma malignant
required: sms:false

GastrinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastrinoma NOS
required: sms:false

Gastrointestinalstromaltumormalignant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Gastrointestinal stromal tumor malignant
required: sms:false

Gliomamalignant
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Glioma malignant
required: sms:false

GliomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Glioma NOS
required: sms:false

Haemangioblastoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Haemangioblastoma
required: sms:false

Haemangiosarcoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Haemangiosarcoma
required: sms:false

Hepatocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Hepatocarcinoma
required: sms:false

Hepatocellularadenoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Hepatocellular adenoma
required: sms:false

HepatocellularcarcinomaNOS
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Hepatocellular carcinoma NOS
required: sms:false

Hepatocholangiocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Hepatocholangiocarcinoma
required: sms:false

Hepatoidadenocarcinoma
type: Class
comment: TBD
subclass of: PrimaryDiagnosis
is part of: schema.biothings.io
display name: Hepatoid adenocarcinoma
required: sms:false