[ { "Component": "PublicationManifest", "HTAN Grant ID": "CA233238", "HTAN Center ID": "HTA3", "Publication Content Type": "Prepublication site for reviewers", "DOI": "https://doi.org/10.1101/2025.10.04.680402", "Title": "Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease", "Authors": "Kelley E. Anderson, Linh M. Tran, Kostyantyn Krysan, Yohana Kefella, Lingge Yu, Gregory A. Fishbein, Erika F. Rodriguez, Maryam Shabihkhani, Daniel P. Stefanko, Emily Green, Gang Liu, Hanqiao Liu, Sherry Zhang, Erin Kane, Mitra Mehrad, Avrum E. Spira, Steven M. Dubinett, Eric J. Burks, Sarah A. Mazzilli, Marc E. Lenburg, Jennifer E. Beane", "Corresponding Author": "Jennifer E Beane", "Corresponding Author ORCID": "https://orcid.org/0000-0002-6699-2132", "Year of Publication": "2026", "Location of Publication": "Molecular Cancer Research", "Publication Abstract": "Lung adenocarcinoma (LUAD), the most common form of lung cancer, is a heterogeneous disease with highly variable histopathologic features and clinical outcomes. LUAD premalignant lesions (PMLs) are localized proliferative lesions of atypical pneumocytes that proliferate along the alveolar walls. In this study, we characterized the molecular heterogeneity across PMLs, regardless of histologic designation, and identified four unique groups or \u201carchetypes\u201d of PMLs using bulk RNA and exome sequencing data from laser captured microdissected PMLs, normal, and tumor tissue from LUAD resection cases. The archetypes were defined based on expression of recurrent gene co-expression modules discovered using the LUAD PMLs profiled and three publicly available datasets. One PML archetype, termed \u201cproliferation\u201d, was associated with increased expression of genes involved in cell proliferation, a pro-tumor immune environment, and enrichment for EGFR driver mutations. Another archetype, termed \u201cnormal-like\u201d, was associated with similar features to normal tissue, an anti-tumor immune response, and lacked enrichment for driver mutations compared to other archetypes. We projected the PML archetypes into independent gene expression datasets profiling LUAD and found that tumors closest to the proliferation archetype were enriched for multiple features of aggressive LUAD, including high tumor grade and lymph node invasion, and had significantly lower disease-free survival. Proliferation archetype PMLs may represent a subset of lesions with more aggressive features that could improve patient stratification and suggest novel targets for lung cancer interception.", "License": "", "PMID": "https://pubmed.ncbi.nlm.nih.gov/41278661/", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319666", "Supporting Link Description": "Full dataset of the whole transcriptome sequencing data in GEO", "Publication-associated HTAN Parent Data File ID": [ "HTA3_80002_583946915", "HTA3_80002_773001243", "HTA3_80002_333429132", "HTA3_80005_992401879", "HTA3_80005_853782758", "HTA3_80005_639159870", "HTA3_80008_573784965", "HTA3_80008_534713128", "HTA3_80010_538643539", "HTA3_80010_926280300", "HTA3_80010_849031354", "HTA3_80012_902933426", "HTA3_80012_974798501", "HTA3_80012_600301579", "HTA3_80012_307722107", "HTA3_80013_964205735", "HTA3_80013_448595568", "HTA3_80013_989277349", "HTA3_80013_606694133", "HTA3_80013_370699039", "HTA3_80014_237108878", "HTA3_80014_218476702", "HTA3_80014_703208303", "HTA3_80014_319368986", "HTA3_80014_725524319", "HTA3_80014_971312040", "HTA3_80014_767214093", "HTA3_80014_453946840", "HTA3_80014_132559565", "HTA3_80015_008807726", "HTA3_80015_062560183", "HTA3_80015_621457419", "HTA3_80016_299331991", "HTA3_80016_244430279", "HTA3_80016_948522659", "HTA3_80016_748391943", "HTA3_80016_702311298", "HTA3_80017_826039026", "HTA3_80017_567313075", "HTA3_80017_501418947", "HTA3_80019_618659162", "HTA3_80019_769269566", "HTA3_80019_605888256", "HTA3_80020_589375222", "HTA3_80020_259661993", "HTA3_80020_884140750", "HTA3_80020_127160176", "HTA3_80020_125095439", "HTA3_80020_399398394", "HTA3_80020_604989881", "HTA3_80020_780849891", "HTA3_80020_414299846", "HTA3_80020_798172312", "HTA3_80021_623138313", "HTA3_80023_388790199", "HTA3_80023_238788565", "HTA3_80023_816922963", "HTA3_80024_849771793", "HTA3_80024_685160958", "HTA3_80025_472927764", "HTA3_80025_252321146", "HTA3_80025_300827607", "HTA3_80026_690999120", "HTA3_80026_176237462", "HTA3_80026_795244549", "HTA3_80026_388740043", "HTA3_80027_455896852", "HTA3_80027_208540323", "HTA3_80027_267268314", "HTA3_80027_361914775", "HTA3_80030_311421309", "HTA3_80030_767744560", "HTA3_80030_394333902", "HTA3_80030_203970078", "HTA3_80030_031896475", "HTA3_80030_950075832", "HTA3_80030_219908497", "HTA3_80030_664898680", "HTA3_80030_554024427", "HTA3_80030_670731578", "HTA3_80030_022404237", "HTA3_80030_773872496", "HTA3_80002_399131961", "HTA3_80002_179490702", "HTA3_80002_275821000", "HTA3_80005_053275116", "HTA3_80005_864896651", "HTA3_80005_413479693", "HTA3_80008_236529725", "HTA3_80008_882553609", "HTA3_80010_404056824", "HTA3_80010_188117972", "HTA3_80010_827910502", "HTA3_80012_675530546", "HTA3_80012_260530746", "HTA3_80012_313078057", "HTA3_80012_163104915", "HTA3_80013_268939242", "HTA3_80013_901513216", "HTA3_80013_541536118", "HTA3_80013_939318607", "HTA3_80013_366473158", "HTA3_80014_120403656", "HTA3_80014_546157720", "HTA3_80014_742267363", "HTA3_80014_504107244", "HTA3_80014_499002991", "HTA3_80014_615450769", "HTA3_80014_561755475", "HTA3_80014_985404020", "HTA3_80014_810824257", "HTA3_80015_080256223", "HTA3_80015_859335814", "HTA3_80015_815605930", "HTA3_80016_575899512", "HTA3_80016_717034425", "HTA3_80016_744310400", "HTA3_80016_896634080", "HTA3_80016_913143938", "HTA3_80017_840769760", "HTA3_80017_640442955", "HTA3_80017_913001544", "HTA3_80019_598332975", "HTA3_80019_064488206", "HTA3_80019_812413789", "HTA3_80020_006681562", "HTA3_80020_296812819", "HTA3_80020_344190726", "HTA3_80020_352881130", "HTA3_80020_982493183", "HTA3_80020_006953676", "HTA3_80020_956010380", "HTA3_80020_305336012", "HTA3_80020_141213698", "HTA3_80020_577806523", "HTA3_80021_978767141", "HTA3_80023_199775503", "HTA3_80023_623578101", "HTA3_80023_564479131", "HTA3_80024_098931211", "HTA3_80024_785641710", "HTA3_80025_667629920", "HTA3_80025_575542049", "HTA3_80025_345073856", "HTA3_80026_861577797", "HTA3_80026_683927872", "HTA3_80026_597730036", "HTA3_80026_897684502", "HTA3_80027_375090245", "HTA3_80027_833143789", "HTA3_80027_515209255", "HTA3_80027_575595346", "HTA3_80030_501496873", "HTA3_80030_791529882", "HTA3_80030_697875907", "HTA3_80030_990219519", "HTA3_80030_160901889", "HTA3_80030_738931500", "HTA3_80030_464529475", "HTA3_80030_798555231", "HTA3_80030_723614344", "HTA3_80030_918067131", "HTA3_80030_380001374", "HTA3_80030_938862309" ], "Eutils Date": "2025 Oct 6", "Eutils Title": "Archetype analysis of lung adenocarcinoma premalignancy links heterogeneity in premalignant lesions to diverging features of invasive disease.", "Eutils Journal": "bioRxiv : the preprint server for biology", "Eutils Sort Date": "2025/10/06 00:00", "Eutils Authors": "Anderson KE, Tran LM, Krysan K, Kefella Y, Yu L, Fishbein GA, Rodriguez E, Shabihkhani M, Stefanko DP, Green E, Liu G, Liu H, Zhang S, Kane E, Mehrad M, Spira AE, Dubinett SM, Burks EJ, Mazzilli SA, Lenburg ME, Beane JE", "Eutils DOI": "10.1101/2025.10.04.680402", "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233238", "HTAN Center ID": "HTA3", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.ajpath.2024.03.009", "Title": "Graph Perceiver Network for Lung Tumor and Bronchial Premalignant Lesion Stratification from Histopathology", "Authors": "Rushin H Gindra, Yi Zheng, Emily J Green, Mary E Reid, Sarah A Mazzilli, Daniel T Merrick, Eric J Burks, Vijaya B Kolachalama, Jennifer E Beane", "Corresponding Author": "Vijaya B Kolachalama,Jennifer E Beane", "Corresponding Author ORCID": "https://orcid.org/0000-0002-5312-8644,https://orcid.org/0000-0002-6699-2132", "Year of Publication": "2024", "Location of Publication": "The American Journal of Pathology", "Publication Abstract": "Bronchial premalignant lesions (PMLs) precede the development of invasive lung squamous cell carcinoma (LUSC), posing a significant challenge in distinguishing those likely to advance to LUSC from those that might regress without intervention. This study followed a novel computational approach, the Graph Perceiver Network, leveraging hematoxylin and eosin\u2013stained whole slide images to stratify endobronchial biopsies of PMLs across a spectrum from normal to tumor lung tissues. The Graph Perceiver Network outperformed existing frameworks in classification accuracy predicting LUSC, lung adenocarcinoma, and nontumor lung tissue on The Cancer Genome Atlas and Clinical Proteomic Tumor Analysis Consortium datasets containing lung resection tissues while efficiently generating pathologist-aligned, class-specific heatmaps. The network was further tested using endobronchial biopsies from two data cohorts, containing normal to carcinoma in situ histology. It demonstrated a unique capability to differentiate carcinoma in situ lung squamous PMLs based on their progression status to invasive carcinoma. The network may have utility in stratifying PMLs for chemoprevention trials or more aggressive follow-up.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/38588853/", "Publication contains HTAN ID": "Yes", "Data Type": "H&E", "Tool": "Yes", "Supporting Link": "https://github.com/vkola-lab/ajpa2024", "Supporting Link Description": "Computer scripts and manuals are made available on GitHub", "Publication-associated HTAN Parent Data File ID": [ "HTA3_0001_1901119", "HTA3_0001_1900482", "HTA3_0001_1900589", "HTA3_0001_1900898", "HTA3_0001_1901120", "HTA3_0001_1990001", "HTA3_0001_1990004", "HTA3_0001_1990002", "HTA3_0001_1990003", "HTA3_0001_1900903", "HTA3_0001_1990005", "HTA3_0001_1900587", "HTA3_0001_1901117", "HTA3_0001_1900586", "HTA3_0001_1901116", "HTA3_0001_1901315", "HTA3_0001_1900585", "HTA3_0001_1901314", "HTA3_0001_1901115", "HTA3_0001_1900480", "HTA3_0001_1900481", "HTA3_0001_1900588", "HTA3_0001_1900900", "HTA3_0001_1901118", "HTA3_0002_1900441", 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"HTA3_0036_1900298", "HTA3_0036_1900913", "HTA3_0036_1900914", "HTA3_0036_1901405", "HTA3_0036_1900297", "HTA3_0036_1900911", "HTA3_0036_1901404", "HTA3_0037_1900344", "HTA3_0037_1900751", "HTA3_0038_1900770", "HTA3_0038_1901075", "HTA3_0038_1901390", "HTA3_0038_1901076", "HTA3_0038_1901391", "HTA3_0038_1900771", "HTA3_0038_1901077", "HTA3_0038_1901392", "HTA3_0039_1901003", "HTA3_0039_1901002", "HTA3_0039_1901220", "HTA3_0039_1901004", "HTA3_0039_1901222", "HTA3_0039_1901005", "HTA3_0039_1901224", "HTA3_0040_1901100", "HTA3_0040_1901284", "HTA3_0040_1901098", "HTA3_0040_1901283", "HTA3_0041_1900796", "HTA3_0041_1900922", "HTA3_0041_1901183", "HTA3_0041_1900795", "HTA3_0041_1900919", "HTA3_0041_1901182", "HTA3_0042_1900906", "HTA3_0042_1901028", "HTA3_0042_1900907", "HTA3_0042_1901029", "HTA3_0043_1901043", "HTA3_0043_1901350", "HTA3_0043_1901349", "HTA3_0044_1900967", "HTA3_0044_1901132", "HTA3_0044_1900968", "HTA3_0044_1901133", "HTA3_0044_1901397", "HTA3_0044_1900293", "HTA3_0044_1900965", "HTA3_0044_1901130", "HTA3_0044_1900966", "HTA3_0044_1901131", "HTA3_0044_1901396", "HTA3_0045_1900893", "HTA3_0045_1900894", "HTA3_0045_1901241", "HTA3_0045_1900891", "HTA3_0045_1901238", "HTA3_0046_1900766", "HTA3_0046_1901292", "HTA3_0046_1900953", "HTA3_0046_1901293", "HTA3_0046_1900765", "HTA3_0046_1900952", "HTA3_0047_1901021", "HTA3_0047_1901216", "HTA3_0047_1901411", "HTA3_0047_1901022", "HTA3_0048_1900965", "HTA3_0048_1901275", "HTA3_0048_1901273", "HTA3_0048_1901381", "HTA3_0048_1900882", "HTA3_0048_1901380", "HTA3_0049_1901187", "HTA3_0050_1900998", "HTA3_0050_1901235", "HTA3_0050_1900997", "HTA3_0051_1901162", "HTA3_0051_1901334", "HTA3_0052_1901018", "HTA3_0052_1901301", "HTA3_0052_1901017", "HTA3_0052_1901302", "HTA3_0052_1901015", "HTA3_0052_1901014", "HTA3_0052_1901299" ], "Eutils Date": "2024 Jul", "Eutils Title": "Graph Perceiver Network for Lung Tumor and Bronchial Premalignant Lesion Stratification from Histopathology.", "Eutils Journal": "The American journal of pathology", "Eutils Sort Date": "2024/07/01 00:00", "Eutils Authors": "Gindra RH, Zheng Y, Green EJ, Reid ME, Mazzilli SA, Merrick DT, Burks EJ, Kolachalama VB, Beane JE", "Eutils DOI": "10.1016/j.ajpath.2024.03.009", "Cited In Number": 6, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=38588853" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233238", "HTAN Center ID": "HTA3", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1126/science.ads9145", "Title": "Aberrant basal cell clonal dynamics shape early lung carcinogenesis", "Authors": "Sandra G\u00f3mez-L\u00f3pez, Ahmed S. N. Alhendi, Moritz J. Przybilla, Ignacio Bordeu, Zoe E. Whiteman, Timothy Butler, Maral J. Rouhani, Lukas Kalinke, Imran Uddin, Kate E. J. Otter, Deepak P. Chandrasekharan, Marta Lebrusant-Fernandez, Abigail Y. L. Shurr, Pascal F. Durrenberger, David A. Moore, Mary Falzon, James L. Reading, I\u00f1igo Martincorena, Benjamin D. Simons, Peter J. Campbell, Sam M. Janes", "Corresponding Author": "Sam M. Janes", "Corresponding Author ORCID": "https://orcid.org/0000-0002-6634-5939", "Year of Publication": "2025", "Location of Publication": "Science", "Publication Abstract": "Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we find that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions develop from a few highly mutated clones that dominate most of the bronchial tree. Multi-site sequencing in human patients confirms the presence of clonally related preinvasive lesions across distinct airway regions. Our work identifies a transition in basal cell clonal dynamics, and an associated shift in basal cell fate, as drivers of field cancerization in the lung.", "License": "CC BY 4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/40310937/", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "https://www.ebi.ac.uk/ena/browser/text-search?query=ERP128764,https://www.ebi.ac.uk/ena/browser/text-search?query=ERP136782,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276610,https://wwwdev.ebi.ac.uk/ega/studies/EGAS00001008114,https://zenodo.org/records/15168190", "Supporting Link Description": "ENA murine WGS^^^ENA murine scRNA-seq^^^GEO human scRNA-seq^^^EGA Whole exome multiregion sequencing data from human preinvasive airway biopsies^^^Custom R, Python and Bash scripts available on Zenodo", "Publication-associated HTAN Parent Data File ID": [ "HTA3_70104_83851742", "HTA3_70104_94048361", "HTA3_70119_40875095", "HTA3_70119_88344309", "HTA3_70132_25669123", "HTA3_70132_84630732", "HTA3_70132_95012230", "HTA3_70149_92034584", "HTA3_70149_45927757", "HTA3_70152_43206893", "HTA3_70152_53127247", "HTA3_70152_91726405", "HTA3_70104_45369574", "HTA3_70104_61474389", "HTA3_70119_74758459", "HTA3_70119_16191158", "HTA3_70132_72428473", "HTA3_70132_95211549", "HTA3_70132_21985147", "HTA3_70149_3866769", "HTA3_70149_18919332", "HTA3_70152_70544039", "HTA3_70152_75751011", "HTA3_70152_38090720", "HTA3_70104_55783153", "HTA3_70104_19979641", "HTA3_70119_82586006", "HTA3_70119_54235828", "HTA3_70132_32361657", "HTA3_70132_93435694", "HTA3_70132_12230399", "HTA3_70149_16408998", "HTA3_70149_84371533", "HTA3_70152_34855982", "HTA3_70152_78534853", "HTA3_70152_58583554", "HTA3_70104_66759873", "HTA3_70104_97338889", "HTA3_70119_34582834", "HTA3_70119_19361838", "HTA3_70132_47230112", "HTA3_70132_24567020", "HTA3_70132_42318352", "HTA3_70149_27474655", "HTA3_70149_77055932", "HTA3_70152_65437509", "HTA3_70152_13791271", "HTA3_70152_60307324" ], "Eutils Date": "2025 Jun 12", "Eutils Title": "Aberrant basal cell clonal dynamics shape early lung carcinogenesis.", "Eutils Journal": "Science (New York, N.Y.)", "Eutils Sort Date": "2025/06/12 00:00", "Eutils Authors": "G\u00f3mez-L\u00f3pez S, Alhendi ASN, Przybilla MJ, Bordeu I, Whiteman ZE, Butler T, Rouhani MJ, Kalinke L, Uddin I, Otter KEJ, Chandrasekharan DP, Lebrusant-Fernandez M, Shurr AYL, Durrenberger PF, Moore DA, Falzon M, Reading JL, Martincorena I, Simons BD, Campbell PJ, Janes SM", "Eutils DOI": "10.1126/science.ads9145", "Cited In Number": 6, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=40310937" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233238", "HTAN Center ID": "HTA3", "Publication Content Type": "Prepublication site for reviewers", "DOI": "", "Title": "Epithelial miR-149 up-regulation is associated with immunosuppression via MHC- I in progressive bronchial premalignant lesions", "Authors": "B Ning, D Chiu, RM Pfefferkorn, Y Kefella, E Kane, V Reyes-Ortiz, G Liu, S Zhang, H Liu, L Sultan, E Green, M Constant, AE Spira, JD Campbell, ME Reid, X Varelas, EJ Burks, ME Lenburg, SA Mazzilli, JE Beane", "Corresponding Author": "Jennifer E Beane", "Corresponding Author ORCID": "https://orcid.org/0000-0002-6699-2132", "Year of Publication": "2025", "Location of Publication": "TBD", "Publication Abstract": "The molecular drivers of progression of bronchial premalignant lesions to invasive lung squamous cell carcinoma are not well defined. Prior work profiling longitudinally collected premalignant lung bronchial biopsies by RNA sequencing defined a transcriptional molecular subtype, the proliferative subtype, enriched with biopsies containing bronchial dysplasia. Within the proliferative subtype, a gene co-expression module associated with interferon gamma signaling and antigen processing/presentation was down-regulated in progressive/persistent versus regressive lesions. Here, RNA from these same lesions was profiled by microRNA (miRNA) sequencing and a miRNA-gene network analysis identified hsa-miR-149-5p to be a potential regulator of the antigen presentation co-expression module associated with lesion progression. hsa-miR-149-5p was found to be predominantly expressed in the epithelium and up-regulated in progressive/persistent versus regressive proliferative lesions. The transcriptional coactivator of MHC class I gene expression, NLRC5, is a predicted target of hsa-miR-149-5p, and both it and the genes it regulates were down-regulated in progressive/persistent lesions. MicroRNA in situ hybridization of hsa-miR-149-5p in tissue from adjacent fixed biopsies showed that hsa-miR-149-5p was increased in areas of bronchial dysplasia in progressive/persistent versus regressive lesions. Imaging mass cytometry showed that NLRC5 protein expression was decreased in progressive/persistent versus regressive lesions within areas of hyperplasia, metaplasia, and dysplasia. Additionally, basal cells with lower levels of NLRC5 were further from CD8 T cells, suggesting a functional consequence of reduced functional MHC class I gene expression in lesions with high hsa-miR-149-5p expression. hsa-miR-149-5p may be a novel therapeutic target for preventing PML progression via immunosuppression.", "License": "", "PMID": "", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA3_0015_1900571", "HTA3_0005_1900325", "HTA3_0015_1900864", "HTA3_0005_1300728", "HTA3_0015_1901327", "HTA3_0007_1900455", "HTA3_0007_1900456", "HTA3_0007_1900453", "HTA3_0007_1900528", "HTA3_0007_1900526", "HTA3_0007_1900527", "HTA3_0001_1900480", "HTA3_0001_1900589", "HTA3_0001_1900587", "HTA3_0001_1900588", "HTA3_0021_1300464", "HTA3_0021_1900465", "HTA3_0010_1900503", "HTA3_0010_1900504", "HTA3_0021_1900581", "HTA3_0001_1900898", "HTA3_0001_1900903", 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"Title": "Attention-based deep learning for analysis of pathology images and gene expression data in lung squamous premalignant lesions", "Authors": "Lingyi Xu, Yohana Kefella, Yichi Zhang, Regan D. Conrad, Kelley E. Anderson, Kostyantyn Krysan, Gang Liu, Erin Kane, Adam Pennycuick, Daniel T. Merrick, Sam M. Janes, Mary E. Reid, Eric J. Burks, Ehab Billatos, Sarah A. Mazzilli, Vijaya B. Kolachalama, Jennifer E. Beane", "Corresponding Author": "Vijaya B Kolachalama,Jennifer E Beane", "Corresponding Author ORCID": "https://orcid.org/0000-0002-5312-8644,https://orcid.org/0000-0002-6699-2132", "Year of Publication": "2026", "Location of Publication": "Genome Medicine", "Publication Abstract": "Molecular and cellular alterations to the normal pseudostratified columnar bronchial epithelium results in the development of bronchial premalignant lesions through a histologic progression from normal to hyperplasia, metaplasia, dysplasia (mild, moderate, and severe), carcinoma in situ and invasive carcinoma. Endobronchial biopsies obtained via various bronchoscopy techniques are formalin fixed paraffin embedded, and hematoxylin and eosin stained (H&E) to access the pathologic features and histologic grade of the tissue. Several studies have also identified molecular alterations associated with lesion histology and progression. The broad and continuous spectrum of histologic and molecular changes makes reproducible stratification of lesions across multiple studies challenging. Here we propose a transformer-based framework that flexibly utilizes transcriptomic and histologic patterns to distinguish lesions with bronchial dysplasia or worse from normal, hyperplasia, and metaplasia. We leveraged H&E whole slide images (WSIs) of endobronchial biopsies and bulk gene expression data (GE) from previously published studies as well as new data obtained from high-risk patients. Models trained using both WSIs and GE compared to a single data modality had higher performance. On an external testing dataset of WSIs, the AUROC of the model trained on WSIs plus GE was 0.761\u00b10.015 compared to 0.690\u00b10.027 for model trained on WSIs. On external testing datasets of GE, the AUROC of the model trained on WSIs plus GE was 0.890\u00b10.023 versus 0.816\u00b10.032 for a model trained on GE. Based on these results, we leveraged data across 4 studies to train a flexible fusion model that allows one or both data modalities to be used in training. The model achieved an AUROC of 0.809\u00b10.036 on external testing WSIs data and 0.903\u00b10.022 on external testing GE data. Despite model training on a binary label, model probabilities are associated with histologic grade and the model identifies gene expression alterations associated with bronchial dysplasia across multiple studies. This framework maps bronchial premalignant lesions that contain at least one data modality into a spectrum of disease. In the future, a framework trained on multiple data modalities may be useful in predicting premalignant disease severity, progression, and interception agent efficacy.", "License": "", "PMID": "", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109743,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114489,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE33479,https://idr.openmicroscopy.org/webclient/?show=project-1251,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300258,https://doi.org/10.5281/zenodo.17362964,https://github.com/vkola-lab/gm2025", "Supporting Link Description": "PCA Dataset 1 bulk RNA sequencing profiles are available from the Gene Expression Omnibus database under accession GSE109743^^^The Colorado SPORE cohort microarray data is available from the Gene Expression Omnibus database under accession GSE114489^^^The Jules Bordet Institute cohort7 microarray data is accessible under accession GSE33479^^^Imaging data from the Pennycuick study can be obtained via the IDR image portal under accession idr0082^^^DECAMP-1 bulk RNA-seq data is available via the Gene Expression Omnibus database under accession GSE300258^^^DECAMP-1 imaging data is available via Zenodo under accession 17362964^^^Python scripts are available on GitHub", "Publication-associated HTAN Parent Data File ID": [ "HTA3_0001_369092737", "HTA3_0001_1901119", "HTA3_0001_1900482", "HTA3_0001_1900589", "HTA3_0001_1900898", "HTA3_0001_1901120", "HTA3_0001_1900903", "HTA3_0001_1900587", "HTA3_0001_661345606", "HTA3_0001_1901117", "HTA3_0001_1900586", "HTA3_0001_1901116", "HTA3_0001_1901315", "HTA3_0001_1900585", "HTA3_0001_1901314", "HTA3_0001_1901115", "HTA3_0001_1900481", "HTA3_0001_1900588", "HTA3_0001_1900900", "HTA3_0001_1901118", "HTA3_0002_1900441", "HTA3_0002_1900442", "HTA3_0003_1900694", "HTA3_0003_244756755", "HTA3_0003_1900693", "HTA3_0003_1900947", "HTA3_0004_1900604", 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Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma", "Authors": "Jane Yanagawa, Linh M Tran, Ramin Salehi-Rad, Raymond J Lim, Camelia Dumitras, Eileen Fung, William D Wallace, Ashley E Prosper, Gregory Fishbein, Conor Shea, Rui Hong, Bitta Kahangi, John J Deng, Adam C Gower, Bin Liu, Joshua D Campbell, Sarah A Mazzilli, Jennifer E Beane, Humam Kadara, Marc E Lenburg, Avrum E Spira, Denise R Aberle, Kostyantyn Krysan, Steven M Dubinett", "Corresponding Author": "Jane Yanagawa,Kostyantyn Krysan,Steven M. Dubinett", "Corresponding Author ORCID": "https://orcid.org/0000-0001-9619-1814,https://orcid.org/0000-0003-0250-1346,https://orcid.org/0000-0003-3656-8039", "Year of Publication": "2023", "Location of Publication": "Cancer Research", "Publication Abstract": "A greater understanding of molecular, cellular, and immunological changes during the early stages of lung adenocarcinoma development could improve diagnostic and therapeutic approaches in patients with pulmonary nodules at risk for lung cancer. To elucidate the immunopathogenesis of early lung tumorigenesis, we evaluated surgically resected pulmonary nodules representing the spectrum of early lung adenocarcinoma as well as associated normal lung tissues using single-cell RNA sequencing and validated the results by flow cytometry and multiplex immunofluorescence (MIF). Single-cell transcriptomics revealed a significant decrease in gene expression associated with cytolytic activities of tumor-infiltrating natural killer and natural killer T cells. This was accompanied by a reduction in effector T cells and an increase of CD4+ regulatory T cells (Treg) in subsolid nodules. An independent set of resected pulmonary nodules consisting of both adenocarcinomas and associated premalignant lesions corroborated the early increment of Tregs in premalignant lesions compared with the associated normal lung tissues by MIF. Gene expression analysis indicated that cancer-associated alveolar type 2 cells and fibroblasts may contribute to the deregulation of the extracellular matrix, potentially affecting immune infiltration in subsolid nodules through ligand-receptor interactions. These findings suggest that there is a suppression of immune surveillance across the spectrum of early-stage lung adenocarcinoma.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/37477508/", "Publication contains HTAN ID": "No", "Data Type": "scRNA-seq", "Tool": "No", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA3_0000_0714695763", "HTA3_0000_4353967957", "HTA3_0042_11009061", "HTA3_0042_11009062", "HTA3_50044_064914069", "HTA3_50044_0656432", "HTA3_50044_0784241127", "HTA3_50044_078453035", "HTA3_50044_0870876639", "HTA3_50044_119848113", "HTA3_50044_120369288", "HTA3_50044_1379117", "HTA3_50044_152452024", "HTA3_50044_2965609361", "HTA3_50044_3100852", "HTA3_50044_349145473", "HTA3_50044_360602271", "HTA3_50044_369130691", "HTA3_50044_378595865", "HTA3_50044_4292376748", "HTA3_50044_4386440", "HTA3_50044_4876935", "HTA3_50044_5005666", "HTA3_50044_507217530", "HTA3_50044_5160300694", 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"HTA3_8006_9344315119", "HTA3_8006_9744592748" ], "Eutils Date": "2023 Oct 2", "Eutils Title": "Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma.", "Eutils Journal": "Cancer research", "Eutils Sort Date": "2023/10/02 00:00", "Eutils Authors": "Yanagawa J, Tran LM, Salehi-Rad R, Lim RJ, Dumitras C, Fung E, Wallace WD, Prosper AE, Fishbein G, Shea C, Hong R, Kahangi B, Deng JJ, Gower AC, Liu B, Campbell JD, Mazzilli SA, Beane JE, Kadara H, Lenburg ME, Spira AE, Aberle DR, Krysan K, Dubinett SM", "Eutils DOI": "10.1158/0008-5472.CAN-23-0128", "Cited In Number": 14, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=37477508" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233285", "HTAN Center ID": "HTA4", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1182/blood.2021013442", "Title": "Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia", "Authors": "Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-Hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-Yang Ding, Stephen P Hunger, Carolyn A Felix, Hao Wu, Patrick A Brown, Erin M Guest, David M Barrett, Kathrin M Bernt, Kai Tan", "Corresponding Author": "Kathrin M Bernt,Kai Tan", "Corresponding Author ORCID": "https://orcid.org/0000-0002-0691-356X,https://orcid.org/0000-0002-9104-5567", "Year of Publication": "2022", "Location of Publication": "Blood", "Publication Abstract": "KMT2A-rearranged (KMT2A-r) infant acute lymphoblastic leukemia (ALL) is a devastating malignancy with a dismal outcome, and younger age at diagnosis is associated with increased risk of relapse. To discover age-specific differences and critical drivers that mediate poor outcome in KMT2A-r ALL, we subjected KMT2A-r leukemias and normal hematopoietic cells from patients of different ages to single-cell multiomics analyses. We uncovered the following critical new insights: leukemia cells from patients <6 months have significantly increased lineage plasticity. Steroid response pathways are downregulated in the most immature blasts from younger patients. We identify a hematopoietic stem and progenitor-like (HSPC-like) population in the blood of younger patients that contains leukemic blasts and form an immunosuppressive signaling circuit with cytotoxic lymphocytes. These observations offer a compelling explanation for the ability of leukemias in young patients to evade chemotherapy and immune-mediated control. Our analysis also revealed preexisting lymphomyeloid primed progenitors and myeloid blasts at initial diagnosis of B-ALL. Tracking of leukemic clones in 2 patients whose leukemia underwent a lineage switch documented the evolution of such clones into frank acute myeloid leukemia (AML). These findings provide critical insights into KMT2A-r ALL and have clinical implications for molecularly targeted and immunotherapy approaches. Beyond infant ALL, our study demonstrates the power of single-cell multiomics to detect tumor intrinsic and extrinsic factors affecting rare but critical subpopulations within a malignant population that ultimately determines patient outcome.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/34864916/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq, scATAC-seq", "Tool": "No", "Supporting Link": "https://github.com/tanlabcode/KMT2Ar_Paper", "Supporting Link Description": "Analysis scripts", "Publication-associated HTAN Parent Data File ID": [ "HTA4_0_40001", "HTA4_0_40002", "HTA4_0_40003", "HTA4_0_40004", "HTA4_0_40005", "HTA4_0_40006", "HTA4_0_40007", "HTA4_0_40008", "HTA4_0_40009", "HTA4_0_40010", "HTA4_0_80001", "HTA4_0_80002", "HTA4_0_80003", "HTA4_0_80004", "HTA4_0_80005", "HTA4_0_80006", "HTA4_0_80007", "HTA4_0_80008", "HTA4_0_80009", "HTA4_10_10125", "HTA4_10_10126", "HTA4_10_10127", "HTA4_10_10128", "HTA4_10_20025", "HTA4_10_30076", 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"HTA4_7_50107", "HTA4_7_50108", "HTA4_8_10097", "HTA4_8_10098", "HTA4_8_10099", "HTA4_8_10100", "HTA4_8_20018", "HTA4_8_30055", "HTA4_8_30056", "HTA4_8_30057", "HTA4_8_50079", "HTA4_8_50080", "HTA4_8_50081", "HTA4_8_50082", "HTA4_8_50083", "HTA4_8_50084", "HTA4_9_10141", "HTA4_9_10142", "HTA4_9_10143", "HTA4_9_10144", "HTA4_9_20029", "HTA4_9_30088", "HTA4_9_30089", "HTA4_9_30090", "HTA4_9_50145", "HTA4_9_50146", "HTA4_9_50147", "HTA4_9_50148", "HTA4_9_50149", "HTA4_9_50150" ], "Eutils Date": "2022 Apr 7", "Eutils Title": "Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.", "Eutils Journal": "Blood", "Eutils Sort Date": "2022/04/07 00:00", "Eutils Authors": "Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K", "Eutils DOI": "10.1182/blood.2021013442", "Cited In Number": 67, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=34864916" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233285", "HTAN Center ID": "HTA4", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1158/2159-8290.cd-24-0046", "Title": "Identification and characterization of chemotherapy resistant high-risk neuroblastoma persister cells", "Authors": "Liron D Grossmann, Chia-Hui Chen, Yasin Uzun, Anusha Thadi, Adam J Wolpaw, Kevin Louault, Yael Goldstein, Lea F Surrey, Daniel Martinez, Matteo Calafatti, Mark Gerelus, Peng Gao, Lobin Lee, Khushbu Patel, Rebecca S Kaufman, Guy Shani, Alvin Farrel, Sharon Moshitch-Moshkovitz, Paris Grimaldi, Matthew Shapiro, Nathan M Kendsersky, Jarrett M Lindsay, Colleen E Casey, Kateryna Krytska, Laura Scolaro, Matthew Tsang, David Groff, Smita Matkar, Josh R Kalna, Emily Mycek, Jayne McDevitt, Erin Runbeck, Tasleema Patel, Kathrin M Bernt, Shahab Asgharzadeh, Yves A DeClerck, Yael P Mosse, Kai Tan, John M Maris", "Corresponding Author": "Kai Tan,John M Maris", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9104-5567,https://orcid.org/0000-0002-8088-7929", "Year of Publication": "2024", "Location of Publication": "Cancer Discovery", "Publication Abstract": "Relapse rates in high-risk neuroblastoma remain exceedingly high. The malignant cells that are responsible for relapse have not been identified, and mechanisms of therapy resistance remain poorly understood. Here, we used single nucleus RNA sequencing and bulk whole genome sequencing to identify and characterize the residual malignant persister cells that survive chemotherapy from a cohort of 20 matched diagnosis and definitive surgery tumor samples from patients treated with high-risk neuroblastoma induction chemotherapy. We show that persister cells share common mechanisms of chemotherapy escape including suppression of MYCN activity and activation of NF-\u03baB signaling, the latter is further enhanced by cell-cell communication between the malignant cells and the tumor microenvironment. Overall, our work dissects the transcriptional landscape of cellular persistence in high-risk neuroblastoma and paves the way to the development of new therapeutic strategies to prevent disease relapse.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39083807/", "Publication contains HTAN ID": "Yes", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103400", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1002_103402", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103342", "HTA4_1004_103344", "HTA4_1004_103344", "HTA4_1004_103344", "HTA4_1004_103344", 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"HTA4_1001_1951", "HTA4_1001_1954", "HTA4_1001_1957", "HTA4_1001_1946", "HTA4_1001_1949", "HTA4_1001_1952", "HTA4_1001_1955", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_2398", "HTA4_1001_3528", "HTA4_1001_3526", "HTA4_1001_3527", "HTA4_1001_4398", "HTA4_1001_4398", "HTA4_1001_4398", "HTA4_1001_1959", "HTA4_1001_1962", "HTA4_1001_1965", "HTA4_1001_1968", "HTA4_1001_1960", "HTA4_1001_1963", "HTA4_1001_1966", "HTA4_1001_1969", "HTA4_1001_1958", "HTA4_1001_1961", "HTA4_1001_1964", "HTA4_1001_1967", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_2399", "HTA4_1001_3531", "HTA4_1001_3529", "HTA4_1001_3530", "HTA4_1001_4399", "HTA4_1001_4399", "HTA4_1001_4399", 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"https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39083807" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233285", "HTAN Center ID": "HTA4", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.xcrm.2026.102766", "Title": "A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma", "Authors": "Jonathan H Sussman, Derek A Oldridge, Wenbao Yu, Chia-Hui Chen, Abigail M Zellmer, Jiazhen Rong, Arianne Parvaresh-Rizi, Anusha Thadi, Austin Yang, Joseph S Tumulty, Barbara Xiong, David W Wu, Yusha Sun, Shovik Bandyopadhyay, Jason Xu, Stephanie Brosius, Una Yamamoto Barkardottir, Isabelle Seka, Kyung Jin Ahn, Omar Elghawy, Amy E Baxter, Mateusz P Koptyra, Rami S Vanguri, Stephanie McGrory, Phillip B Storm, Nduka M Amankulor, Mariarita Santi, Angela N Viaene, Nancy Zhang, Thomas De Raedt, Kristina Cole, Kai Tan", "Corresponding Author": "Kai Tan", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9104-5567", "Year of Publication": "2026", "Location of Publication": "Cell Reports Medicine", "Publication Abstract": "Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that is a leading cause of pediatric cancer death. While pHGG shares many similarities with adult glioma, it comprises distinct disease entities. In this study, we longitudinally profile a molecularly diverse cohort of 16 pHGG patients through single-nucleus RNA and ATAC sequencing, whole-genome sequencing, and CODEX spatial proteomics to capture the evolution of neoplastic and microenvironmental features during disease progression and treatment. We define a set of core pHGG neoplastic cell states and observe differential tumor-myeloid interactions between malignant cell phenotypes. We find that essential neuromodulators and the interferon response are upregulated post-therapy, implicating them as malignant cell-intrinsic targets. We observe an increase in oligodendrocytes upon progression and that they coordinate spatial motifs with proneural tumor cells. This multiomic atlas of longitudinal pHGG captures features of therapy response and provides a scalable reference for the study of pediatric brain tumors.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/42030938/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq, scATAC-seq, CODEX, Bulk DNA", "Tool": "No", "Supporting Link": "https://cellxgene.cziscience.com/collections/9ceda3d2-a55e-4b82-a91a-0190d947459a,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292623,https://github.com/tanlabcode/pHGG_Atlas,https://sageb.io/jApjyC", "Supporting Link Description": "snRNA-seq data objects can be explored interactively on CELLxGENE^^^Bulk RNA-seq data from the in vitro experiments^^^Software and source code created for this study are publicly available on GitHub^^^H&E and Xenium Data", "Publication-associated HTAN Parent Data File ID": [ "HTA4_2001_26668", "HTA4_2001_26670", "HTA4_2004_26698", "HTA4_2001_26672", "HTA4_2001_66668", "HTA4_2001_66670", 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"HTA4_2005_126691", "HTA4_2005_136691", "HTA4_2007_116687", "HTA4_2007_126687", "HTA4_2007_136687", "HTA4_2008_116684", "HTA4_2008_126684", "HTA4_2008_136684", "HTA4_2011_116688", "HTA4_2011_126688", "HTA4_2011_136688", "HTA4_2013_116685", "HTA4_2013_126685", "HTA4_2013_136685", "HTA4_2013_116686", "HTA4_2013_126686", "HTA4_2013_136686" ], "UCSC Cell Browser Link": "https://cells.ucsc.edu/?ds=htan-chop+sussman", "Eutils Date": "2026 May 19", "Eutils Title": "A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma.", "Eutils Journal": "Cell reports. Medicine", "Eutils Sort Date": "2026/05/19 00:00", "Eutils Authors": "Sussman JH, Oldridge DA, Yu W, Chen CH, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Yang A, Tumulty JS, Xiong B, Wu DW, Sun Y, Bandyopadhyay S, Xu J, Brosius S, Barkardottir UY, Seka I, Ahn KJ, Elghawy O, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, De Raedt T, Cole K, Tan K", "Eutils DOI": "10.1016/j.xcrm.2026.102766", "Cited In Number": 2, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=42030938" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233285", "HTAN Center ID": "HTA4", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41588-025-02158-6", "Title": "Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring", "Authors": "Wenbao Yu, Rumeysa Biyik-Sit1, Yasin Uzun, Chia-Hui Chen, Anusha Thadi, Jonathan H. Sussman, Minxing Pang, Chi-Yun Wu, Liron D. Grossmann, Peng Gao, David W. Wu, Aliza Yousey, Mei Zhang, Christina S. Turn, Zhan Zhang, Shovik Bandyopadhyay, Jeffrey Huang, Tasleema Patel, Changya Chen , Daniel Martinez, Lea F. Surrey, Michael D. Hogarty, Kathrin Bernt, Nancy Zhang, John M. Maris, and Kai Tan", "Corresponding Author": "Kai Tan", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9104-5567", "Year of Publication": "2025", "Location of Publication": "Nature Genetics", "Publication Abstract": "High-risk neuroblastoma (NBL) is a leading cause of pediatric cancer death. The evolution of the tumor microenvironment under therapy remains obscure. In this study, we longitudinally profiled 22 high-risk NBL patients before and after induction chemotherapy through single-nucleus RNA and ATAC sequencing and whole-genome sequencing. We identified profound shifts in tumor and immune cell subpopulations and nominated enhancer-driven transcriptional regulators of NBL neoplastic states. Reduced proliferating and expanded metabolically active neoplastic states predicted a poorer diagnostic outcome, whereas expanded and more differentiated neuronal-like states were linked to a more favorable prognosis. Mesenchymal neoplastic cells increased and correlated with a poorer response to chemotherapy. Macrophages significantly expanded towards pro-angiogenic, immunosuppressive, and metabolic phenotypes. We identified paracrine signaling networks and established the HB-EGF/ERBB4 axis between macrophage and neoplastic subsets which promoted tumor growth through the induction of ERK signaling. These findings collectively reveal novel intrinsic and extrinsic regulators of therapy response in high-risk NBL.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/40229600/", "Publication contains HTAN ID": "Yes", "Supporting Link": "https://cellxgene.cziscience.com/collections/cee845e3-ec04-4781-9e2a-28734bb4f7ba^^^https://doi.org/10.5281/zenodo.14261274", "Supporting Link Description": "Processed snRNA-seq data in the CELLxGENE database^^^Processed Xenium transcriptomic and scRNA-seq data in the mono- and co-culture experiments in the Zenodo repository", "Publication-associated HTAN Parent Data File ID": [ "HTA4_1016_93337", "HTA4_1016_93338", "HTA4_1016_93339", "HTA4_1016_93340", "HTA4_1016_93341", "HTA4_1016_93342", "HTA4_1016_93343", "HTA4_1016_93344", "HTA4_1007_93345", "HTA4_1007_93346", "HTA4_1007_93347", "HTA4_1007_93348", "HTA4_1007_93349", "HTA4_1007_93350", "HTA4_1007_93351", "HTA4_1007_93352", "HTA4_1004_93353", "HTA4_1004_93354", "HTA4_1004_93355", 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"HTA4_1023_53643", "HTA4_1023_53644", "HTA4_1023_53645", "HTA4_1023_53646", "HTA4_1023_53647", "HTA4_1023_53648", "HTA4_1023_53649", "HTA4_1023_53650", "HTA4_1023_53651", "HTA4_1023_53652", "HTA4_1023_53653", "HTA4_1023_53654", "HTA4_1023_53655", "HTA4_1023_53656", "HTA4_1023_53657", "HTA4_1023_53658", "HTA4_1023_53659", "HTA4_1023_53660", "HTA4_1023_53661", "HTA4_1014_53662", "HTA4_1014_53663", "HTA4_1014_53664", "HTA4_1014_53665", "HTA4_1014_53666", "HTA4_1014_53667", "HTA4_1014_53668", "HTA4_1014_53669", "HTA4_1014_53670", "HTA4_1014_53671", "HTA4_1014_53672", "HTA4_1014_53673", "HTA4_1014_53674", "HTA4_1014_53675", "HTA4_1014_53676", "HTA4_1014_53677", "HTA4_1018_53678", "HTA4_1018_53679", "HTA4_1018_53680", "HTA4_1014_53681", "HTA4_1014_53682", "HTA4_1014_53683", "HTA4_1018_53684", "HTA4_1018_53685", "HTA4_1018_53686", "HTA4_1018_53687", "HTA4_1018_53688", "HTA4_1018_53689", "HTA4_1018_53690", "HTA4_1018_53691", "HTA4_1011_53692", "HTA4_1011_53693", "HTA4_1011_53694", "HTA4_1011_53695", "HTA4_1011_53696", "HTA4_1011_53697", "HTA4_1011_53698", "HTA4_1011_53699", "HTA4_1011_53700", "HTA4_1011_53701", "HTA4_1011_53702", "HTA4_1011_53703", "HTA4_1011_53704", "HTA4_1011_53705", "HTA4_1011_53706", "HTA4_1011_53707", "HTA4_1011_53708", "HTA4_1011_53709", "HTA4_1011_53710", "HTA4_1011_53711", "HTA4_1011_53712", "HTA4_1011_53713", "HTA4_1011_53714", "HTA4_1011_53715", "HTA4_1023_53716", "HTA4_1023_53717", "HTA4_1023_53718", "HTA4_1023_53719", "HTA4_1023_53720", "HTA4_1023_53721", "HTA4_1023_53722", "HTA4_1023_53723", "HTA4_1023_53724", "HTA4_1023_53725", "HTA4_1023_53726", "HTA4_1023_53727", "HTA4_1023_53728", "HTA4_1023_53729", "HTA4_1023_53730", "HTA4_1023_53731", "HTA4_1023_53732", "HTA4_1023_53733", "HTA4_1023_53734", "HTA4_1023_53735", "HTA4_1023_53736", "HTA4_1023_53737", "HTA4_1023_53738", "HTA4_1023_53739", "HTA4_1021_53740", "HTA4_1021_53741", "HTA4_1021_53742", "HTA4_1021_53743", "HTA4_1021_53744", "HTA4_1021_53745", "HTA4_1021_53746", "HTA4_1021_53747", "HTA4_1021_53748", "HTA4_1021_53749", "HTA4_1021_53750", "HTA4_1021_53751", "HTA4_1021_53752", "HTA4_1021_53753", "HTA4_1021_53754", "HTA4_1021_53755", "HTA4_1021_53756", "HTA4_1021_53757", "HTA4_1021_53758", "HTA4_1021_53759", "HTA4_1021_53760", "HTA4_1021_53761", "HTA4_1021_53762", "HTA4_1021_53763", "HTA4_1021_53764", "HTA4_1021_53765", "HTA4_1021_53766", "HTA4_1021_53767", "HTA4_1021_53768", "HTA4_1021_53769", "HTA4_1021_53770", "HTA4_1021_53771", "HTA4_1021_53772", "HTA4_1021_53773", "HTA4_1021_53774", "HTA4_1021_53775", "HTA4_1021_53776", "HTA4_1021_53777", "HTA4_1021_53778", "HTA4_1021_53779", "HTA4_1021_53780", "HTA4_1021_53781", "HTA4_1021_53782", "HTA4_1021_53783", "HTA4_1021_53784", "HTA4_1021_53785", "HTA4_1021_53786", "HTA4_1021_53787", "HTA4_1021_53788", "HTA4_1021_53789", "HTA4_1021_53790", "HTA4_1021_53791", "HTA4_1021_53792", "HTA4_1021_53793", "HTA4_1021_53794", "HTA4_1021_53795", "HTA4_1021_53796", "HTA4_1021_53797", "HTA4_1021_53798", "HTA4_1021_53799", "HTA4_1010_53800", "HTA4_1010_53801", "HTA4_1010_53802", "HTA4_1010_53803", "HTA4_1010_53804", "HTA4_1010_53805", "HTA4_1010_53806", "HTA4_1010_53807", "HTA4_1010_53808", "HTA4_1010_53809", "HTA4_1010_53810", "HTA4_1010_53811", "HTA4_1010_53812", "HTA4_1010_53813", "HTA4_1010_53814", "HTA4_1010_53815", "HTA4_1010_53816", "HTA4_1010_53817", "HTA4_1010_53818", "HTA4_1010_53819", "HTA4_1010_53820", "HTA4_1010_53821", "HTA4_1010_53822", "HTA4_1010_53823", "HTA4_1001_53824", "HTA4_1001_53825", "HTA4_1001_53826", "HTA4_1001_53827", "HTA4_1001_53828", "HTA4_1001_53829", "HTA4_1001_53830", "HTA4_1001_53831", "HTA4_1001_53832", "HTA4_1001_53833", "HTA4_1001_53834", "HTA4_1001_53835", "HTA4_1001_53836", "HTA4_1001_53837", "HTA4_1001_53838", "HTA4_1001_53839", "HTA4_1010_53840", "HTA4_1010_53841", "HTA4_1010_53842", "HTA4_1010_53843", "HTA4_1010_53844", "HTA4_1010_53845", "HTA4_1010_53846", "HTA4_1010_53847", "HTA4_1010_53848", "HTA4_1010_53849", "HTA4_1010_53850", "HTA4_1010_53851", "HTA4_1010_53852", "HTA4_1010_53853", "HTA4_1010_53854", "HTA4_1010_53855", "HTA4_1010_53856", "HTA4_1010_53857", "HTA4_1010_53858", "HTA4_1010_53859", "HTA4_1010_53860", "HTA4_1010_53861", "HTA4_1010_53862", "HTA4_1010_53863", "HTA4_1012_53864", "HTA4_1012_53865", "HTA4_1012_53866", "HTA4_1012_53867", "HTA4_1012_53868", "HTA4_1012_53869", "HTA4_1012_53870", "HTA4_1012_53871", "HTA4_1012_53872", "HTA4_1012_53873", "HTA4_1012_53874", "HTA4_1012_53875", "HTA4_1012_53876", "HTA4_1012_53877", "HTA4_1012_53878", "HTA4_1012_53879", "HTA4_1012_53880", "HTA4_1012_53881", "HTA4_1012_53882", "HTA4_1012_53883", "HTA4_1012_53884", "HTA4_1012_53885", "HTA4_1012_53886", "HTA4_1012_53887", "HTA4_1019_53888", "HTA4_1019_53889", "HTA4_1019_53890", "HTA4_1019_53891", "HTA4_1019_53892", "HTA4_1019_53893", "HTA4_1001_53894", "HTA4_1001_53895", "HTA4_1001_53896", "HTA4_1001_53897", "HTA4_1001_53898", "HTA4_1001_53899", "HTA4_1001_53900", "HTA4_1001_53901", "HTA4_1001_53902", "HTA4_1001_53903", "HTA4_1001_53904", "HTA4_1001_53905", "HTA4_1001_53906", "HTA4_1001_53907", "HTA4_1001_53908", "HTA4_1001_53909", "HTA4_1019_53910", "HTA4_1019_53911", "HTA4_1019_53912", "HTA4_1019_53913", "HTA4_1019_53914", "HTA4_1019_53915", "HTA4_1019_53916", "HTA4_1019_53917", "HTA4_1019_53918", "HTA4_1019_53919", "HTA4_1019_53920", "HTA4_1019_53921", "HTA4_1019_53922", "HTA4_1019_53923", "HTA4_1019_53924", "HTA4_1019_53925", "HTA4_1021_53926", "HTA4_1021_53927", "HTA4_1021_53928", "HTA4_1021_53929", "HTA4_1021_53930", "HTA4_1021_53931", "HTA4_1021_53932", "HTA4_1021_53933", "HTA4_1021_53934", "HTA4_1021_53935", "HTA4_1021_53936", "HTA4_1021_53937", "HTA4_1021_53938", "HTA4_1021_53939", "HTA4_1021_53940", "HTA4_1021_53941", "HTA4_1021_53942", "HTA4_1021_53943", "HTA4_1021_53944", "HTA4_1021_53945", "HTA4_1021_53946", "HTA4_1021_53947", "HTA4_1021_53948", "HTA4_1021_53949", "HTA4_1003_53950", "HTA4_1003_53951", "HTA4_1003_53952", "HTA4_1003_53953", "HTA4_1003_53954", "HTA4_1003_53955", "HTA4_1003_53956", "HTA4_1003_53957", "HTA4_1003_53958", "HTA4_1003_53959", "HTA4_1003_53960", "HTA4_1003_53961", "HTA4_1003_53962", "HTA4_1003_53963", "HTA4_1003_53964", "HTA4_1003_53965", "HTA4_1003_53966", "HTA4_1003_53967", "HTA4_1003_53968", "HTA4_1003_53969", "HTA4_1003_53970", "HTA4_1003_53971", "HTA4_1003_53972", "HTA4_1003_53973", "HTA4_1016_53974", "HTA4_1016_53975", "HTA4_1016_53976", "HTA4_1016_53977", "HTA4_1016_53978", "HTA4_1016_53979", "HTA4_1016_53980", "HTA4_1016_53981", "HTA4_1016_63335", "HTA4_1007_63336", "HTA4_1004_63337", "HTA4_1004_63338", "HTA4_1013_63339", "HTA4_1008_63340", "HTA4_1022_63341", "HTA4_1022_63342", "HTA4_1006_63343", "HTA4_1006_63344", "HTA4_1013_63345", "HTA4_1020_63346", "HTA4_1007_63347", "HTA4_1015_63348", "HTA4_1015_63349", "HTA4_1020_63350", "HTA4_1006_63351", "HTA4_1011_63352", "HTA4_1005_63353", "HTA4_1005_63354", "HTA4_1009_63355", "HTA4_1023_63356", "HTA4_1014_63357", "HTA4_1018_63358", "HTA4_1014_63359", "HTA4_1018_63360", "HTA4_1011_63361", "HTA4_1023_63362", "HTA4_1021_63363", "HTA4_1021_63364", "HTA4_1010_63365", "HTA4_1001_63366", "HTA4_1001_63367", "HTA4_1010_63368", "HTA4_1012_63369", "HTA4_1019_63370", "HTA4_1019_63371", "HTA4_1001_63372", "HTA4_1019_63373", "HTA4_1021_63374", "HTA4_1003_63375", "HTA4_1016_63376", "HTA4_1016_63377", "HTA4_1007_63378", "HTA4_1004_63379", "HTA4_1004_63380", "HTA4_1013_63381", "HTA4_1008_63382", "HTA4_1022_63383", "HTA4_1022_63384", "HTA4_1006_63385", "HTA4_1006_63386", "HTA4_1013_63387", "HTA4_1020_63388", "HTA4_1007_63389", "HTA4_1015_63390", "HTA4_1015_63391", "HTA4_1020_63392", "HTA4_1006_63393", "HTA4_1011_63394", "HTA4_1005_63395", "HTA4_1005_63396", "HTA4_1009_63397", "HTA4_1023_63398", "HTA4_1014_63399", "HTA4_1018_63400", "HTA4_1014_63401", "HTA4_1018_63402", "HTA4_1011_63403", "HTA4_1023_63404", "HTA4_1021_63405", "HTA4_1021_63406", "HTA4_1010_63407", "HTA4_1001_63408", "HTA4_1001_63409", "HTA4_1010_63410", "HTA4_1012_63411", "HTA4_1019_63412", "HTA4_1019_63413", "HTA4_1001_63414", "HTA4_1019_63415", "HTA4_1021_63416", "HTA4_1003_63417", "HTA4_1016_63418", "HTA4_1016_73335", "HTA4_1007_73336", "HTA4_1004_73337", "HTA4_1004_73338", "HTA4_1013_73339", "HTA4_1008_73340", "HTA4_1022_73341", "HTA4_1022_73342", "HTA4_1006_73343", "HTA4_1006_73344", "HTA4_1013_73345", "HTA4_1020_73346", "HTA4_1007_73347", "HTA4_1015_73348", "HTA4_1015_73349", "HTA4_1020_73350", "HTA4_1006_73351", "HTA4_1011_73352", "HTA4_1005_73353", "HTA4_1005_73354", "HTA4_1009_73355", "HTA4_1023_73356", "HTA4_1014_73357", "HTA4_1018_73358", "HTA4_1014_73359", "HTA4_1018_73360", "HTA4_1011_73361", "HTA4_1023_73362", "HTA4_1021_73363", "HTA4_1021_73364", "HTA4_1010_73365", "HTA4_1001_73366", "HTA4_1001_73367", "HTA4_1010_73368", "HTA4_1012_73369", "HTA4_1019_73370", "HTA4_1019_73371", "HTA4_1001_73372", "HTA4_1019_73373", "HTA4_1021_73374", "HTA4_1003_73375", "HTA4_1016_73376", "HTA4_000_83337", "HTA4_000_83338", "HTA4_000_83339", "HTA4_1001_1334", "HTA4_1001_1335", "HTA4_1001_1336", "HTA4_1001_1337", "HTA4_1001_1338", "HTA4_1001_1339", "HTA4_1001_1340", "HTA4_1001_1341", "HTA4_1001_1342", "HTA4_1001_1343", "HTA4_1001_1344", "HTA4_1001_1345", "HTA4_1001_1346", "HTA4_1001_1347", "HTA4_1001_1348", "HTA4_1001_1349", "HTA4_1001_1350", "HTA4_1001_1351", "HTA4_1001_1352", "HTA4_1001_1353", "HTA4_1001_1354", "HTA4_1001_1355", "HTA4_1001_1356", "HTA4_1001_1357", "HTA4_1001_1358", "HTA4_1001_1359", "HTA4_1001_1360", "HTA4_1001_1361", "HTA4_1001_1362", "HTA4_1001_1363", "HTA4_1001_1364", "HTA4_1001_1365", "HTA4_1001_1366", "HTA4_1001_1367", "HTA4_1001_1368", "HTA4_1001_1369", "HTA4_1001_1370", "HTA4_1001_1371", "HTA4_1001_1372", "HTA4_1001_1373", "HTA4_1001_1374", "HTA4_1001_1375", "HTA4_1001_1376", "HTA4_1001_1377", "HTA4_1001_1378", "HTA4_1001_1379", "HTA4_1001_1380", "HTA4_1001_1381", "HTA4_1001_1382", "HTA4_1001_1383", "HTA4_1001_1384", "HTA4_1001_1385", "HTA4_1001_1386", "HTA4_1001_1387", "HTA4_1001_1388", "HTA4_1001_1389", "HTA4_1001_1390", "HTA4_1001_1391", "HTA4_1001_1392", "HTA4_1001_1393", "HTA4_1001_1394", "HTA4_1001_1395", "HTA4_1001_1396", "HTA4_1001_1397", "HTA4_1001_1398", "HTA4_1001_1399", "HTA4_1001_1400", "HTA4_1001_1401", "HTA4_1001_1402", "HTA4_1001_1403", "HTA4_1001_1404", "HTA4_1001_1405", "HTA4_1001_1406", "HTA4_1001_1407", "HTA4_1001_1408", "HTA4_1001_1409", "HTA4_1001_1410", "HTA4_1001_1411", "HTA4_1001_1412", "HTA4_1001_1413", "HTA4_1001_1414", "HTA4_1001_1415", "HTA4_1001_1416", "HTA4_1001_1417", "HTA4_1001_1418", "HTA4_1001_1419", "HTA4_1001_1420", "HTA4_1001_1421", "HTA4_1001_1422", "HTA4_1001_1423", "HTA4_1001_1424", "HTA4_1001_1425", "HTA4_1001_1426", "HTA4_1001_1427", "HTA4_1001_1428", "HTA4_1001_1429", "HTA4_1001_1430", "HTA4_1001_1431", "HTA4_1001_1432", "HTA4_1001_1433", "HTA4_1001_1434", "HTA4_1001_1435", "HTA4_1001_1436", "HTA4_1001_1437", "HTA4_1001_1438", "HTA4_1001_1439", "HTA4_1001_1440", "HTA4_1001_1441", "HTA4_1001_1442", "HTA4_1001_1443", "HTA4_1001_1444", "HTA4_1001_1445", "HTA4_1001_1446", "HTA4_1001_1447", "HTA4_1001_1448", "HTA4_1001_1449", "HTA4_1001_1450", "HTA4_1001_1451", "HTA4_1001_1452", "HTA4_1001_1453", "HTA4_1001_1454", "HTA4_1001_1455", "HTA4_1001_1456", "HTA4_1001_1457", "HTA4_1001_1458", "HTA4_1001_1459", "HTA4_1001_1460", "HTA4_1001_1461", "HTA4_1001_1462", "HTA4_1001_1463", "HTA4_1001_1464", "HTA4_1001_1465", "HTA4_1001_1466", "HTA4_1001_1467", "HTA4_1001_1468", "HTA4_1001_1469", "HTA4_1001_1470", "HTA4_1001_1471", "HTA4_1001_1472", "HTA4_1001_1473", "HTA4_1001_1474", "HTA4_1001_1475", "HTA4_1001_1476", "HTA4_1001_1477", "HTA4_1001_1478", "HTA4_1001_1479", "HTA4_1001_1480", "HTA4_1001_1481", "HTA4_1001_1482", "HTA4_1001_1483", "HTA4_1001_1484", "HTA4_1001_1485", "HTA4_1001_1486", "HTA4_1001_1487", "HTA4_1001_1488", "HTA4_1001_1489", "HTA4_1001_1490", "HTA4_1001_1491", "HTA4_1001_1492", "HTA4_1001_1493", "HTA4_1001_1494", "HTA4_1001_1495", "HTA4_1001_1496", "HTA4_1001_1497", "HTA4_1001_1498", "HTA4_1001_1499", "HTA4_1001_1500", "HTA4_1001_1501", "HTA4_1001_1502", "HTA4_1001_1503", "HTA4_1001_1504", "HTA4_1001_1505", "HTA4_1001_1506", "HTA4_1001_1507", "HTA4_1001_1508", "HTA4_1001_1509", "HTA4_1001_1510", "HTA4_1001_1511", "HTA4_1001_1512", "HTA4_1001_1513", "HTA4_1001_1514", "HTA4_1001_1515", "HTA4_1001_1516", "HTA4_1001_1517", "HTA4_1001_1518", "HTA4_1001_1519", "HTA4_1001_1520", "HTA4_1001_1521", "HTA4_1001_1522", "HTA4_1001_1523", "HTA4_1001_1524", "HTA4_1001_1525", "HTA4_1001_1526", "HTA4_1001_1527", "HTA4_1001_1528", "HTA4_1001_1529", "HTA4_1001_1530", "HTA4_1001_1531", "HTA4_1001_1532", "HTA4_1001_1533", "HTA4_1001_1534", "HTA4_1001_1535", "HTA4_1001_1536", "HTA4_1001_1537", "HTA4_1001_1538", "HTA4_1001_1539", "HTA4_1001_1540", "HTA4_1001_1541", "HTA4_1001_1542", "HTA4_1001_1543", "HTA4_1001_1544", "HTA4_1001_1545", "HTA4_1001_1546", "HTA4_1001_1547", "HTA4_1001_1548", "HTA4_1001_1549", "HTA4_1001_1550", "HTA4_1001_1551", "HTA4_1001_1552", "HTA4_1001_1553", "HTA4_1001_1554", "HTA4_1001_1555", "HTA4_1001_1556", "HTA4_1001_1557", "HTA4_1001_1558", "HTA4_1001_1559", "HTA4_1001_1560", "HTA4_1001_1561", "HTA4_1001_1562", "HTA4_1001_1563", "HTA4_1001_1564", "HTA4_1001_1565", "HTA4_1001_1566", "HTA4_1001_1567", "HTA4_1001_1568", "HTA4_1001_1569", "HTA4_1001_1570", "HTA4_1001_1571", "HTA4_1001_1572", "HTA4_1001_1573", "HTA4_1001_1574", "HTA4_1001_1575", "HTA4_1001_1576", "HTA4_1001_1577", "HTA4_1001_1578", "HTA4_1001_1579", "HTA4_1001_1580", "HTA4_1001_1581", "HTA4_1001_1582", "HTA4_1001_1583", "HTA4_1001_1584", "HTA4_1001_1585", "HTA4_1001_1586", "HTA4_1001_1587", "HTA4_1001_1588", "HTA4_1001_1589", "HTA4_1001_1590", "HTA4_1001_1591", "HTA4_1001_1592", "HTA4_1001_1593", "HTA4_1001_1594", "HTA4_1001_1595", "HTA4_1001_1596", "HTA4_1001_1597", "HTA4_1001_1598", "HTA4_1001_1599", "HTA4_1001_1600", "HTA4_1001_1601", "HTA4_1001_1602", "HTA4_1001_1603", "HTA4_1001_1604", "HTA4_1001_1605", "HTA4_1001_1606", "HTA4_1001_1607", "HTA4_1001_1608", "HTA4_1001_1609", "HTA4_1001_1610", "HTA4_1001_1611", "HTA4_1001_1612", "HTA4_1001_1613", "HTA4_1001_1614", "HTA4_1001_1615", "HTA4_1001_1616", "HTA4_1001_1617", "HTA4_1001_1618", "HTA4_1001_1619", "HTA4_1001_1620", "HTA4_1001_1621", "HTA4_1001_1622", "HTA4_1001_1623", "HTA4_1001_1624", "HTA4_1001_1625", "HTA4_1001_1626", "HTA4_1001_1627", "HTA4_1001_1628", "HTA4_1001_1629", "HTA4_1001_1630", "HTA4_1001_1631", "HTA4_1001_1632", "HTA4_1001_1633", "HTA4_1001_1634", "HTA4_1001_1635", "HTA4_1001_1636", "HTA4_1001_1637", "HTA4_1001_1638", "HTA4_1001_1639", "HTA4_1001_1640", "HTA4_1001_1641", "HTA4_1001_1642", "HTA4_1001_1643", "HTA4_1001_1644", "HTA4_1001_1645", "HTA4_1001_1646", "HTA4_1001_1647", "HTA4_1001_1648", "HTA4_1001_1649", "HTA4_1001_1650", "HTA4_1001_1651", "HTA4_1001_1652", "HTA4_1001_1653", "HTA4_1001_1654", "HTA4_1001_1655", "HTA4_1001_1656", "HTA4_1001_1657", "HTA4_1001_1658", "HTA4_1001_1659", "HTA4_1001_1660", "HTA4_1001_1661", "HTA4_1001_1662", "HTA4_1001_1663", "HTA4_1001_1664", "HTA4_1001_1665", "HTA4_1001_1666", "HTA4_1001_1667", "HTA4_1001_1668", "HTA4_1001_1669", "HTA4_1001_1670", "HTA4_1001_1671", "HTA4_1001_1672", "HTA4_1001_1673", "HTA4_1001_1674", "HTA4_1001_1675", "HTA4_1001_1676", "HTA4_1001_1677", "HTA4_1001_1678", "HTA4_1001_1679", "HTA4_1001_1680", "HTA4_1001_1681", "HTA4_1001_1682", "HTA4_1001_1683", "HTA4_1001_1684", "HTA4_1001_1685", "HTA4_1001_1686", "HTA4_1001_1687", "HTA4_1001_1688", "HTA4_1001_1689", "HTA4_1001_1690", "HTA4_1001_1691", "HTA4_1001_1692", "HTA4_1001_1693", "HTA4_1001_1694", "HTA4_1001_1695", "HTA4_1001_1696", "HTA4_1001_1697", "HTA4_1001_1698", "HTA4_1001_1699", "HTA4_1001_1700", "HTA4_1001_1701", "HTA4_1001_1702", "HTA4_1001_1703", "HTA4_1001_1704", "HTA4_1001_1705", "HTA4_1001_1706", "HTA4_1001_1707", "HTA4_1001_1708", "HTA4_1001_1709", "HTA4_1001_1710", "HTA4_1001_1711", "HTA4_1001_1712", "HTA4_1001_1713", "HTA4_1001_1714", "HTA4_1001_1715", "HTA4_1001_1716", "HTA4_1001_1717", "HTA4_1001_1718", "HTA4_1001_1719", "HTA4_1001_1720", "HTA4_1001_1721", "HTA4_1001_1722", "HTA4_1001_1723", "HTA4_1001_1724", "HTA4_1001_1725", "HTA4_1001_1726", "HTA4_1001_1727", "HTA4_1001_1728", "HTA4_1001_1729", "HTA4_1001_1730", "HTA4_1001_1731", "HTA4_1001_1732", "HTA4_1001_1733", "HTA4_1001_1734", "HTA4_1001_1735", "HTA4_1001_1736", "HTA4_1001_1737", "HTA4_1001_1738", "HTA4_1001_1739", "HTA4_1001_1740", "HTA4_1001_1741", "HTA4_1001_1742", "HTA4_1001_1743", "HTA4_1001_1744", "HTA4_1001_1745", "HTA4_1001_1746", "HTA4_1001_1747", "HTA4_1001_1748", "HTA4_1001_1749", "HTA4_1001_1750", "HTA4_1001_1751", "HTA4_1001_1752", "HTA4_1001_1753", "HTA4_1001_1754", "HTA4_1001_1755", "HTA4_1001_1756", "HTA4_1001_1757", "HTA4_1001_1758", "HTA4_1001_1759", "HTA4_1001_1760", "HTA4_1001_1761", "HTA4_1001_1762", "HTA4_1001_1763", "HTA4_1001_1764", "HTA4_1001_1765", "HTA4_1001_1766", "HTA4_1001_1767", "HTA4_1001_1768", "HTA4_1001_1769", "HTA4_1001_1770", "HTA4_1001_1771", "HTA4_1001_1772", "HTA4_1001_1773", "HTA4_1001_1774", "HTA4_1001_1775", "HTA4_1001_1776", "HTA4_1001_1777", "HTA4_1001_1778", "HTA4_1001_1779", "HTA4_1001_1780", "HTA4_1001_1781", "HTA4_1001_1782", "HTA4_1001_1783", "HTA4_1001_1784", "HTA4_1001_1785", "HTA4_1001_1786", "HTA4_1001_1787", "HTA4_1001_1788", "HTA4_1001_1789", "HTA4_1001_1790", "HTA4_1001_1791", "HTA4_1001_1792", "HTA4_1001_1793", "HTA4_1001_1794", "HTA4_1001_1795", "HTA4_1001_1796", "HTA4_1001_1797", "HTA4_1001_1798", "HTA4_1001_1799", "HTA4_1001_1800", "HTA4_1001_1801", "HTA4_1001_1802", "HTA4_1001_1803", "HTA4_1001_1804", "HTA4_1001_1805", "HTA4_1001_1806", "HTA4_1001_1807", "HTA4_1001_1808", "HTA4_1001_1809", "HTA4_1001_1810", "HTA4_1001_1811", "HTA4_1001_1812", "HTA4_1001_1813", "HTA4_1001_1814", "HTA4_1001_1815", "HTA4_1001_1816", "HTA4_1001_1817", "HTA4_1001_1818", "HTA4_1001_1819", "HTA4_1001_1820", "HTA4_1001_1821", "HTA4_1001_1822", "HTA4_1001_1823", "HTA4_1001_1824", "HTA4_1001_1825", "HTA4_1001_1826", "HTA4_1001_1827", "HTA4_1001_1828", "HTA4_1001_1829", "HTA4_1001_1830", "HTA4_1001_1831", "HTA4_1001_1832", "HTA4_1001_1833", "HTA4_1001_1834", "HTA4_1001_1835", "HTA4_1001_1836", "HTA4_1001_1837", "HTA4_1001_1838", "HTA4_1001_1839", "HTA4_1001_1840", "HTA4_1001_1841", "HTA4_1001_1842", "HTA4_1001_1843", "HTA4_1001_1844", "HTA4_1001_1845", "HTA4_1001_1846", "HTA4_1001_1847", "HTA4_1001_1848", "HTA4_1001_1849", "HTA4_1001_1850", "HTA4_1001_1851", "HTA4_1001_1852", "HTA4_1001_1853", "HTA4_1001_1854", "HTA4_1001_1855", "HTA4_1001_1856", "HTA4_1001_1857", "HTA4_1001_1858", "HTA4_1001_1859", "HTA4_1001_1860", "HTA4_1001_1861", "HTA4_1001_1862", "HTA4_1001_1863", "HTA4_1001_1864", "HTA4_1001_1865", "HTA4_1001_1866", "HTA4_1001_1867", "HTA4_1001_1868", "HTA4_1001_1869", "HTA4_1001_1870", "HTA4_1001_1871", "HTA4_1001_1872", "HTA4_1001_1873", "HTA4_1001_1874", "HTA4_1001_1875", "HTA4_1001_1876", "HTA4_1001_1877", "HTA4_1001_1878", "HTA4_1001_1879", "HTA4_1001_1880", "HTA4_1001_1881", "HTA4_1001_1882", "HTA4_1001_1883", "HTA4_1001_1884", "HTA4_1001_1885", "HTA4_1001_1886", "HTA4_1001_1887", "HTA4_1001_1888", "HTA4_1001_1889", "HTA4_1001_1890", "HTA4_1001_1891", "HTA4_1001_1892", "HTA4_1001_1893", "HTA4_1001_1894", "HTA4_1001_1895", "HTA4_1001_1896", "HTA4_1001_1897", "HTA4_1001_1898", "HTA4_1001_1899", "HTA4_1001_1900", "HTA4_1001_1901", "HTA4_1001_1902", "HTA4_1001_1903", "HTA4_1001_1904", "HTA4_1001_1905", "HTA4_1001_1906", "HTA4_1001_1907", "HTA4_1001_1908", "HTA4_1001_1909", "HTA4_1001_1910", "HTA4_1001_1911", "HTA4_1001_1912", "HTA4_1001_1913", "HTA4_1001_1914", "HTA4_1001_1915", "HTA4_1001_1916", "HTA4_1001_1917", "HTA4_1001_1918", "HTA4_1001_1919", "HTA4_1001_1920", "HTA4_1001_1921", "HTA4_1001_1922", "HTA4_1001_1923", "HTA4_1001_1924", "HTA4_1001_1925", "HTA4_1001_1926", "HTA4_1001_1927", "HTA4_1001_1928", "HTA4_1001_1929", "HTA4_1001_1930", "HTA4_1001_1931", "HTA4_1001_1932", "HTA4_1001_1933", "HTA4_1001_1934", "HTA4_1001_1935", "HTA4_1001_1936", "HTA4_1001_1937", "HTA4_1001_1938", "HTA4_1001_1939", "HTA4_1001_1940", "HTA4_1001_1941", "HTA4_1001_1942", "HTA4_1001_1943", "HTA4_1001_1944", "HTA4_1001_1945", "HTA4_1001_1946", "HTA4_1001_1947", "HTA4_1001_1948", "HTA4_1001_1949", "HTA4_1001_1950", "HTA4_1001_1951", "HTA4_1001_1952", "HTA4_1001_1953", "HTA4_1001_1954", "HTA4_1001_1955", "HTA4_1001_1956", "HTA4_1001_1957", "HTA4_1001_1958", "HTA4_1001_1959", "HTA4_1001_1960", "HTA4_1001_1961", "HTA4_1001_1962", "HTA4_1001_1963", "HTA4_1001_1964", "HTA4_1001_1965", "HTA4_1001_1966", "HTA4_1001_1967", "HTA4_1001_1968", "HTA4_1001_1969", "HTA4_1001_1970", "HTA4_1001_1971", "HTA4_1001_1972", "HTA4_1001_1973", "HTA4_1001_1974", "HTA4_1001_1975", "HTA4_1001_1976", "HTA4_1001_1977", "HTA4_1001_1978", "HTA4_1001_1979", "HTA4_1001_1980", "HTA4_1001_1981", "HTA4_1001_1982", "HTA4_1001_1983", "HTA4_1001_1984", "HTA4_1001_1985", "HTA4_1001_1986", "HTA4_1001_1987", "HTA4_1001_1988", "HTA4_1001_1989", "HTA4_1001_1990", "HTA4_1001_1991", "HTA4_1001_1992", "HTA4_1001_1993", "HTA4_1001_1994", "HTA4_1001_1995", "HTA4_1001_1996", "HTA4_1001_1997", "HTA4_1001_1998", "HTA4_1001_1999", "HTA4_1001_2000", "HTA4_1001_2001", "HTA4_1001_2002", "HTA4_1001_2003", "HTA4_1001_2004", "HTA4_1001_2005", "HTA4_1001_2006", "HTA4_1001_2007", "HTA4_1001_2008", "HTA4_1001_2009", "HTA4_1001_2010", "HTA4_1001_2011", "HTA4_1001_2012", "HTA4_1001_2013", "HTA4_1001_2014", "HTA4_1001_2015", "HTA4_1001_2016", "HTA4_1001_2017", "HTA4_1001_2018", "HTA4_1001_2019", "HTA4_1001_2020", "HTA4_1001_2021", "HTA4_1001_2022", "HTA4_1001_2023", "HTA4_1001_2024", "HTA4_1001_2025", "HTA4_1001_2026", "HTA4_1001_2027", "HTA4_1001_2028", "HTA4_1001_2029", "HTA4_1001_2030", "HTA4_1001_2031", "HTA4_1001_2032", "HTA4_1001_2033", "HTA4_1001_2034", "HTA4_1001_2035", "HTA4_1001_2036", "HTA4_1001_2037", "HTA4_1001_2038", "HTA4_1001_2039", "HTA4_1001_2040", "HTA4_1001_2041", "HTA4_1001_2042", "HTA4_1001_2043", "HTA4_1001_2044", "HTA4_1001_2045", "HTA4_1001_2046", "HTA4_1001_2047", "HTA4_1001_2048", "HTA4_1001_2049", "HTA4_1001_2050", "HTA4_1001_2051", "HTA4_1001_2052", "HTA4_1001_2053", "HTA4_1001_2054", "HTA4_1001_2055", "HTA4_1001_2056", "HTA4_1001_2057", "HTA4_1001_2058", "HTA4_1001_2059", "HTA4_1001_2060", "HTA4_1001_2061", "HTA4_1001_2062", "HTA4_1001_2063", "HTA4_1001_2064", "HTA4_1001_2065", "HTA4_1001_2066", "HTA4_1001_2067", "HTA4_1001_2068", "HTA4_1001_2069", "HTA4_1001_2070", "HTA4_1001_2071", "HTA4_1001_2072", "HTA4_1001_2073", "HTA4_1001_2074", "HTA4_1001_2075", "HTA4_1001_2076", "HTA4_1001_2077", "HTA4_1001_2078", "HTA4_1001_2079", "HTA4_1001_2080", "HTA4_1001_2081", "HTA4_1001_2082", "HTA4_1001_2083", "HTA4_1001_2084", "HTA4_1001_2085", "HTA4_1001_2086", "HTA4_1001_2087", "HTA4_1001_2088", "HTA4_1001_2089", "HTA4_1001_2090", "HTA4_1001_2091", "HTA4_1001_2092", "HTA4_1001_2093", "HTA4_1001_2094", "HTA4_1001_2095", "HTA4_1001_2096", "HTA4_1001_2097", "HTA4_1001_2098", "HTA4_1001_2099", "HTA4_1001_2100", "HTA4_1001_2101", "HTA4_1001_2102", "HTA4_1001_2103", "HTA4_1001_2104", "HTA4_1001_2105", "HTA4_1001_2106", "HTA4_1001_2107", "HTA4_1001_2108", "HTA4_1001_2109", "HTA4_1001_2110", "HTA4_1001_2111", "HTA4_1001_2112", "HTA4_1001_2113", "HTA4_1001_2114", "HTA4_1001_2115", "HTA4_1001_2116", "HTA4_1001_2117", "HTA4_1001_2118", "HTA4_1001_2119", "HTA4_1001_2120", "HTA4_1001_2121", "HTA4_1001_2122", "HTA4_1001_2123", "HTA4_1001_2124", "HTA4_1001_2125", "HTA4_1001_2126", "HTA4_1001_2127", "HTA4_1001_2128", "HTA4_1001_2129", "HTA4_1001_2130", "HTA4_1001_2131", "HTA4_1001_2132", "HTA4_1001_2133", "HTA4_1001_2134", "HTA4_1001_2135", "HTA4_1001_2136", "HTA4_1001_2137", "HTA4_1001_2138", "HTA4_1001_2139", "HTA4_1001_2140", "HTA4_1001_2141", "HTA4_1001_2142", "HTA4_1001_2143", "HTA4_1001_2144", "HTA4_1001_2145", "HTA4_1001_2146", "HTA4_1001_2147", "HTA4_1001_2148", "HTA4_1001_2149", "HTA4_1001_2150", "HTA4_1001_2151", "HTA4_1001_2152", "HTA4_1001_2153", "HTA4_1001_2154", "HTA4_1001_2155", "HTA4_1001_2156", "HTA4_1001_2157", "HTA4_1001_2158", "HTA4_1001_2159", "HTA4_1001_2160", "HTA4_1001_2161", "HTA4_1001_2162", "HTA4_1001_2163", "HTA4_1001_2164", "HTA4_1001_2165", "HTA4_1001_2166", "HTA4_1001_2167", "HTA4_1001_2168", "HTA4_1001_2169", "HTA4_1001_2170", "HTA4_1001_2171", "HTA4_1001_2172", "HTA4_1001_2173", "HTA4_1001_2174", "HTA4_1001_2175", "HTA4_1001_2176", "HTA4_1001_2177", "HTA4_1001_2178", "HTA4_1001_2179", "HTA4_1001_2180", "HTA4_1001_2181", "HTA4_1001_2182", "HTA4_1001_2183", "HTA4_1001_2184", "HTA4_1001_2185", "HTA4_1001_2186", "HTA4_1001_2187", "HTA4_1001_2188", "HTA4_1001_2189", "HTA4_1001_2190", "HTA4_1001_2191", "HTA4_1001_2334", "HTA4_1001_2335", "HTA4_1001_2336", "HTA4_1001_2337", "HTA4_1001_2338", "HTA4_1001_2339", "HTA4_1001_2340", "HTA4_1001_2341", "HTA4_1001_2342", "HTA4_1001_2343", "HTA4_1001_2344", "HTA4_1001_2345", "HTA4_1001_2346", "HTA4_1001_2347", "HTA4_1001_2348", "HTA4_1001_2349", "HTA4_1001_2350", "HTA4_1001_2351", "HTA4_1001_2352", "HTA4_1001_2353", "HTA4_1001_2354", "HTA4_1001_2355", 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"HTA4_1001_4487", "HTA4_1001_4488", "HTA4_1001_4489", "HTA4_1001_4490", "HTA4_1001_4491", "HTA4_1001_4492", "HTA4_1001_4493", "HTA4_1001_4494", "HTA4_1001_4495", "HTA4_1001_4496", "HTA4_1001_4497", "HTA4_1001_4498", "HTA4_1001_4499", "HTA4_1001_4500", "HTA4_1001_4501", "HTA4_1001_4502", "HTA4_1001_4503", "HTA4_1001_4504", "HTA4_1001_4505", "HTA4_1001_4506", "HTA4_1001_4507", "HTA4_1001_4508", "HTA4_1001_4509", "HTA4_1001_4510", "HTA4_1001_4511", "HTA4_1001_4512", "HTA4_1001_4513", "HTA4_1001_4514", "HTA4_1001_4515", "HTA4_1001_4516", "HTA4_1001_4517", "HTA4_1001_4518", "HTA4_1001_4519", "HTA4_1001_4520", "HTA4_1001_4521", "HTA4_1001_4522", "HTA4_1001_4523", "HTA4_1001_4524" ], "Eutils Date": "2025 May", "Eutils Title": "Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring.", "Eutils Journal": "Nature genetics", "Eutils Sort Date": "2025/05/01 00:00", "Eutils Authors": "Yu W, Biyik-Sit R, Uzun Y, Chen CH, Thadi A, Sussman JH, Pang M, Wu CY, Grossmann LD, Gao P, Wu DW, Yousey A, Zhang M, Turn CS, Zhang Z, Bandyopadhyay S, Huang J, Patel T, Chen C, Martinez D, Surrey LF, Hogarty MD, Bernt K, Zhang NR, Maris JM, Tan K", "Eutils DOI": "10.1038/s41588-025-02158-6", "Cited In Number": 20, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=40229600" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233254", "HTAN Center ID": "HTA6", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1158/0008-5472.can-24-3023", "Title": "Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition", "Authors": "Xiaodi Qin, Siri H Strand, Marissa R Lee, Aashrith Saraswathibhatla, David G P van IJzendoorn, ChunFang Zhu, Sujay Vennam, Sushama Varma, Allison Hall, Rachel E Factor, Lorraine King, Lunden Simpson, Xiaoke Luo, Graham A Colditz, Shu Jiang, Ovijit Chaudhuri, E Shelley Hwang, Jeffrey R Marks, Kouros Owzar, Robert B West", "Corresponding Author": "Robert B West", "Corresponding Author ORCID": "https://orcid.org/0000-0002-8330-8283", "Year of Publication": "2025", "Location of Publication": "Cancer Research", "Publication Abstract": "Ductal carcinoma in situ (DCIS) is a risk factor for subsequent invasive breast cancer. To identify events in DCIS that lead to invasive cancer, we performed single-cell RNA-sequencing (scRNA-seq) on DCIS lesions and matched normal breast tissue. Inferred copy number variation (CNV) was used to identify neoplastic epithelial cells from clinical specimens, which contained a mixture of DCIS and normal ducts. Phylogenetic analysis demonstrated intratumoral clonal heterogeneity that was associated with significant gene expression differences. Classification of epithelial cells into mammary cell states revealed that subclones contained a mixture of cell states, suggesting an ongoing pattern of differentiation after neoplastic transformation. Cell state proportions were significantly different based on estrogen receptor (ER) expression with ER-negative DCIS more closely resembling the distribution in the normal breast, particularly with respect to cells with basal characteristics. Specific alterations in cell state proportions were associated with progression to invasive cancer in a cohort of DCIS with longitudinal outcome. Ongoing transcription of key basement membrane (BM) genes occurred in specific subsets of epithelial cell states, including basal/myoepithelial, which are diminished in DCIS. In the transition to invasive breast cancer, the BM protein laminin, but not COL4, was altered in DCIS adjacent to invasion. Loss of COL4, but not laminin, in an in vitro DCIS model led to an invasive phenotype. These findings suggest that the process of invasion is a loss-of-function event due to an imbalance in critical cell populations essential for BM integrity rather than a gain of an invasive phenotype by neoplastic cells.", "License": "", "PMID": "https://pubmed.ncbi.nlm.nih.gov/40101158/", "Publication contains HTAN ID": "Yes", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA6_2494_7", "HTA6_2494_8", "HTA6_2494_9", "HTA6_2494_10", "HTA6_2494_11", "HTA6_2494_12", "HTA6_2494_13", "HTA6_2494_14", "HTA6_2494_15", "HTA6_2494_16", "HTA6_2494_17", "HTA6_2494_18", "HTA6_2495_6", "HTA6_2495_7", "HTA6_2495_8", "HTA6_2495_9", "HTA6_2495_10", "HTA6_2495_11", "HTA6_2496_2", "HTA6_2496_3", "HTA6_2496_4", "HTA6_2496_5", "HTA6_2496_6", "HTA6_2496_7", "HTA6_2497_2", "HTA6_2497_3", "HTA6_2497_4", "HTA6_2497_5", "HTA6_2497_6", "HTA6_2497_7", "HTA6_2498_5", "HTA6_2498_17", "HTA6_2498_6", "HTA6_2498_18", "HTA6_2498_7", "HTA6_2498_19", 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"HTA6_2544_7", "HTA6_2544_8", "HTA6_2544_9", "HTA6_2545_7", "HTA6_2545_8", "HTA6_2545_9", "HTA6_2546_7", "HTA6_2546_8", "HTA6_2546_9", "HTA6_2519_9", "HTA6_2547_7", "HTA6_2547_8", "HTA6_2547_9", "HTA6_2548_7", "HTA6_2548_8", "HTA6_2548_9", "HTA6_2549_7", "HTA6_2549_8", "HTA6_2549_9", "HTA6_2550_7", "HTA6_2550_8", "HTA6_2550_9", "HTA6_2551_7", "HTA6_2551_8", "HTA6_2551_9", "HTA6_2552_7", "HTA6_2552_8", "HTA6_2552_9", "HTA6_2553_7", "HTA6_2553_8", "HTA6_2553_9", "HTA6_2554_7", "HTA6_2554_8", "HTA6_2554_9", "HTA6_2510_9", "HTA6_0_9", "HTA6_1012_7", "HTA6_1015_7", "HTA6_2129_5", "HTA6_1043_7", "HTA6_1036_7", "HTA6_1054_326", "HTA6_2292_4", "HTA6_2014_269", "HTA6_1053_267", "HTA6_1050_10", "HTA6_2118_5", "HTA6_1098_325", "HTA6_1136_267", "HTA6_2179_7", "HTA6_1135_267", "HTA6_1125_11", "HTA6_1147_7", "HTA6_2077_267", "HTA6_1077_267", "HTA6_2071_267", "HTA6_1097_6", "HTA6_1067_7", "HTA6_1065_7", "HTA6_1072_324", "HTA6_1080_7", "HTA6_1089_267", "HTA6_1122_6", "HTA6_2306_7", "HTA6_2157_4", "HTA6_2156_4", "HTA6_2317_4", "HTA6_2256_6", "HTA6_2268_4", "HTA6_2135_5", "HTA6_2360_7", "HTA6_2384_5", "HTA6_2383_5", "HTA6_2254_7", "HTA6_2166_4", "HTA6_2402_5", "HTA6_2203_5", "HTA6_2113_3", "HTA6_2115_3", "HTA6_2411_2", "HTA6_2145_3", "HTA6_2412_2", "HTA6_2413_2", "HTA6_2165_3", "HTA6_2169_3", "HTA6_2176_3", "HTA6_2414_2", "HTA6_2183_3", "HTA6_2185_3", "HTA6_2415_2", "HTA6_2416_2", "HTA6_2417_2", "HTA6_2418_2", "HTA6_2419_2", "HTA6_2420_2", "HTA6_2421_2", "HTA6_2422_2", "HTA6_2423_2", "HTA6_2424_2", "HTA6_2348_3", "HTA6_2353_3", "HTA6_2425_2", "HTA6_2355_5", "HTA6_2372_5", "HTA6_2426_2", "HTA6_2427_2", "HTA6_2428_2", "HTA6_2429_2", "HTA6_2430_2", "HTA6_2381_3", "HTA6_2396_3", "HTA6_2431_2", "HTA6_2432_2", "HTA6_2433_2", "HTA6_2434_2", "HTA6_2435_2", "HTA6_2436_2", "HTA6_2207_3", "HTA6_2208_3", "HTA6_2209_5", "HTA6_2212_3", "HTA6_2213_3", "HTA6_2214_3", "HTA6_2218_3", "HTA6_2437_2", "HTA6_2438_2", "HTA6_2439_2", "HTA6_2267_3", "HTA6_2440_2", "HTA6_2281_3", "HTA6_2441_2", 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"HTA6_99_33", "HTA6_2473_2", "HTA6_2474_2", "HTA6_2475_2", "HTA6_104_5", "HTA6_2476_2", "HTA6_121_5", "HTA6_122_16", "HTA6_2477_2", "HTA6_100_19", "HTA6_101_22", "HTA6_2478_2", "HTA6_103_20", "HTA6_105_4", "HTA6_107_20", "HTA6_2479_2", "HTA6_2480_2", "HTA6_111_23", "HTA6_112_14", "HTA6_114_21", "HTA6_115_27", "HTA6_2481_2", "HTA6_2482_2", "HTA6_117_21", "HTA6_118_20", "HTA6_120_18", "HTA6_133_4", "HTA6_137_21", "HTA6_138_19", "HTA6_139_23", "HTA6_140_22", "HTA6_144_16", "HTA6_158_18", "HTA6_160_19", "HTA6_167_27", "HTA6_97_22", "HTA6_135_5", "HTA6_136_16", "HTA6_141_20", "HTA6_155_4", "HTA6_162_20", "HTA6_165_22", "HTA6_2483_2", "HTA6_2484_2", "HTA6_2485_2", "HTA6_163_27", "HTA6_166_27", "HTA6_125_18", "HTA6_127_5", "HTA6_128_4", "HTA6_2486_2", "HTA6_129_5", "HTA6_130_17", "HTA6_2487_2", "HTA6_132_4", "HTA6_126_18", "HTA6_2488_2", "HTA6_77_5", "HTA6_151_25", "HTA6_2489_2", "HTA6_6_4", "HTA6_2490_2", "HTA6_2491_2", "HTA6_152_4", "HTA6_2492_2", "HTA6_161_22", "HTA6_2493_2", "HTA6_168_24", "HTA6_33_18", "HTA6_75_20", "HTA6_78_18", "HTA6_82_22", "HTA6_145_16", "HTA6_147_20", "HTA6_63_41", "HTA6_90_16", "HTA6_1012_10", "HTA6_1015_10", "HTA6_2129_10", "HTA6_1043_10", "HTA6_1036_10", "HTA6_1054_329", "HTA6_2014_274", "HTA6_1053_270", "HTA6_1050_13", "HTA6_2118_10", "HTA6_1136_270", "HTA6_2179_10", "HTA6_1135_270", "HTA6_1147_10", "HTA6_2077_272", "HTA6_1077_270", "HTA6_2071_272", "HTA6_1098_328", "HTA6_1097_8", "HTA6_1067_10", "HTA6_1065_10", "HTA6_1072_327", "HTA6_1080_10", "HTA6_1089_270", "HTA6_2306_12", "HTA6_2157_8", "HTA6_2156_8", "HTA6_2317_8", "HTA6_2256_10", "HTA6_2135_10", "HTA6_2360_12", "HTA6_2384_10", "HTA6_2383_10", "HTA6_2166_8", "HTA6_2402_10", "HTA6_2203_10", "HTA6_2268_6", "HTA6_2113_4", "HTA6_2115_4", "HTA6_2411_6", "HTA6_2145_4", "HTA6_2412_6", "HTA6_2413_6", "HTA6_1125_12", "HTA6_2165_4", "HTA6_2169_4", "HTA6_2176_4", "HTA6_2414_6", "HTA6_2183_4", "HTA6_2185_4", "HTA6_2415_6", "HTA6_2416_6", "HTA6_2417_6", "HTA6_2418_6", "HTA6_2419_6", "HTA6_2420_6", "HTA6_2421_6", "HTA6_2422_6", "HTA6_2423_6", "HTA6_2424_6", "HTA6_2348_4", "HTA6_2353_4", "HTA6_2425_6", "HTA6_2355_6", "HTA6_2372_6", "HTA6_2426_6", "HTA6_2427_6", "HTA6_2428_6", "HTA6_2429_6", "HTA6_2430_6", "HTA6_2381_4", "HTA6_1122_7", "HTA6_2396_4", "HTA6_2431_6", "HTA6_2432_6", "HTA6_2433_6", "HTA6_2434_6", "HTA6_2435_6", "HTA6_2436_6", "HTA6_2207_4", "HTA6_2208_4", "HTA6_2209_6", "HTA6_2212_4", "HTA6_2213_4", "HTA6_2214_4", "HTA6_2218_4", "HTA6_2437_6", "HTA6_2254_8", "HTA6_2438_6", "HTA6_2439_6", "HTA6_2267_4", "HTA6_2440_6", "HTA6_2281_4", "HTA6_2441_6", "HTA6_2292_5", "HTA6_2302_4", "HTA6_2442_6", "HTA6_13_17", "HTA6_170_17", "HTA6_48_6", "HTA6_2450_3", "HTA6_59_22", "HTA6_67_15", "HTA6_58_6", "HTA6_2451_3", "HTA6_11_29", "HTA6_12_6", "HTA6_2452_3", "HTA6_2453_3", "HTA6_17_6", "HTA6_2410_23", "HTA6_2454_3", "HTA6_2455_3", "HTA6_35_6", "HTA6_55_5", "HTA6_2456_3", "HTA6_14_27", "HTA6_20_19", "HTA6_29_6", "HTA6_26_19", "HTA6_54_7", "HTA6_62_19", "HTA6_2457_3", "HTA6_2458_3", "HTA6_8_6", "HTA6_2459_3", "HTA6_28_5", "HTA6_30_21", "HTA6_1_7", "HTA6_2_17", "HTA6_3_40", "HTA6_2460_3", "HTA6_18_5", "HTA6_24_5", "HTA6_2461_3", "HTA6_36_28", "HTA6_2462_3", "HTA6_49_17", "HTA6_50_6", "HTA6_2463_3", "HTA6_57_21", "HTA6_2464_3", "HTA6_68_44", "HTA6_89_6", "HTA6_40_15", "HTA6_2465_3", "HTA6_16_5", "HTA6_31_19", "HTA6_34_28", "HTA6_2466_3", "HTA6_41_23", "HTA6_39_6", "HTA6_42_23", "HTA6_44_5", "HTA6_43_21", "HTA6_71_19", "HTA6_7_29", "HTA6_15_6", "HTA6_19_19", "HTA6_25_17", "HTA6_32_19", "HTA6_38_6", "HTA6_2467_3", "HTA6_45_17", "HTA6_73_5", "HTA6_74_6", "HTA6_76_21", "HTA6_79_5", "HTA6_85_21", "HTA6_46_19", "HTA6_69_23", "HTA6_70_5", "HTA6_80_5", "HTA6_47_19", "HTA6_84_21", "HTA6_2468_3", "HTA6_9_17", "HTA6_27_22", "HTA6_2469_3", "HTA6_51_5", "HTA6_21_16", "HTA6_22_24", "HTA6_2470_3", "HTA6_37_19", "HTA6_65_24", "HTA6_66_42", "HTA6_4_32", "HTA6_2471_3", "HTA6_94_19", "HTA6_2472_3", "HTA6_92_26", "HTA6_93_6", "HTA6_52_6", "HTA6_95_19", "HTA6_96_6", "HTA6_53_5", "HTA6_102_26", "HTA6_123_17", "HTA6_124_17", "HTA6_99_34", "HTA6_56_5", "HTA6_2473_3", "HTA6_2474_3", "HTA6_2475_3", "HTA6_104_6", "HTA6_2476_3", "HTA6_121_6", "HTA6_2443_3", "HTA6_122_17", "HTA6_2477_3", "HTA6_100_20", "HTA6_101_23", "HTA6_2478_3", "HTA6_60_22", "HTA6_103_21", "HTA6_105_5", "HTA6_107_21", "HTA6_61_19", "HTA6_2479_3", "HTA6_2480_3", "HTA6_111_24", "HTA6_112_15", "HTA6_114_22", "HTA6_115_28", "HTA6_2481_3", "HTA6_64_28", "HTA6_2482_3", "HTA6_117_22", "HTA6_118_21", "HTA6_120_19", "HTA6_5_6", "HTA6_133_5", "HTA6_137_22", "HTA6_138_20", "HTA6_72_5", "HTA6_139_24", "HTA6_140_23", "HTA6_2444_3", "HTA6_144_17", "HTA6_158_19", "HTA6_160_20", "HTA6_167_28", "HTA6_97_23", "HTA6_81_13", "HTA6_135_6", "HTA6_136_17", "HTA6_141_21", "HTA6_155_5", "HTA6_83_23", "HTA6_162_21", "HTA6_165_23", "HTA6_2483_3", "HTA6_2484_3", "HTA6_2485_3", "HTA6_163_28", "HTA6_166_28", "HTA6_125_19", "HTA6_127_6", "HTA6_128_5", "HTA6_2486_3", "HTA6_86_27", "HTA6_129_6", "HTA6_130_18", "HTA6_2487_3", "HTA6_132_5", "HTA6_87_5", "HTA6_126_19", "HTA6_2488_3", "HTA6_77_6", "HTA6_88_19", "HTA6_151_26", "HTA6_2489_3", "HTA6_6_5", "HTA6_2490_3", "HTA6_2491_3", "HTA6_152_5", "HTA6_2492_3", "HTA6_161_23", "HTA6_2493_3", "HTA6_168_25", "HTA6_2445_3", "HTA6_33_19", "HTA6_75_21", "HTA6_78_19", "HTA6_82_23", "HTA6_145_17", "HTA6_147_21", "HTA6_63_42", "HTA6_90_17", "HTA6_2446_3", "HTA6_98_15", "HTA6_108_7", "HTA6_106_36", "HTA6_109_38", "HTA6_110_30", "HTA6_113_28", "HTA6_116_25", "HTA6_10_5", "HTA6_119_15", "HTA6_2447_3", "HTA6_2448_3", "HTA6_131_6", "HTA6_134_15", "HTA6_142_22", "HTA6_143_21", "HTA6_153_19", "HTA6_154_19", "HTA6_156_7", "HTA6_157_17", "HTA6_2449_3", "HTA6_159_19", "HTA6_164_22", "HTA6_169_17", "HTA6_0_3", "HTA6_0_4", "HTA6_0_5", "HTA6_0_6" ], "Eutils Date": "2025 Jun 16", "Eutils Title": "Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition.", "Eutils Journal": "Cancer research", "Eutils Sort Date": "2025/06/16 00:00", "Eutils Authors": "Qin X, Strand SH, Lee MR, Saraswathibhatla A, van IJzendoorn DGP, Zhu C, Vennam S, Varma S, Hall A, Factor RE, King L, Simpson L, Luo X, Colditz GA, Jiang S, Chaudhuri O, Hwang ES, Marks JR, Owzar K, West RB", "Eutils DOI": "10.1158/0008-5472.CAN-24-3023", "Cited In Number": 4, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=40101158" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233254", "HTAN Center ID": "HTA6", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.cell.2021.12.023", "Title": "Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma", "Authors": "Tyler Risom, David R Glass, Inna Averbukh, Candace C Liu, Alex Baranski, Adam Kagel, Erin F McCaffrey, Noah F Greenwald, Bel\u00e9n Rivero-Guti\u00e9rrez, Siri H Strand, Sushama Varma, Alex Kong, Leeat Keren, Sucheta Srivastava, Chunfang Zhu, Zumana Khair, Deborah J Veis, Katherine Deschryver, Sujay Vennam, Carlo Maley, E Shelley Hwang, Jeffrey R Marks, Sean C Bendall, Graham A Colditz, Robert B West, Michael Angelo", "Corresponding Author": "Robert B West,Michael Angelo", "Corresponding Author ORCID": "https://orcid.org/orcid-search/search?searchQuery=0000-0002-8330-8283,https://orcid.org/0000-0003-1531-5067", "Year of Publication": "2022", "Location of Publication": "Cell", "Publication Abstract": "Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME) accompanying transition to IBC, we used multiplexed ion beam imaging by time of flight (MIBI-TOF) and a 37-plex antibody staining panel to interrogate 79 clinically annotated surgical resections using machine learning tools for cell segmentation, pixel-based clustering, and object morphometrics. Comparison of normal breast with patient-matched DCIS and IBC revealed coordinated transitions between four TME states that were delineated based on the location and function of myoepithelium, fibroblasts, and immune cells. Surprisingly, myoepithelial disruption was more advanced in DCIS patients that did not develop IBC, suggesting this process could be protective against recurrence. Taken together, this HTAN Breast PreCancer Atlas study offers insight into drivers of IBC relapse and emphasizes the importance of the TME in regulating these processes.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/35063072/", "Publication contains HTAN ID": "No", "Data Type": "MIBI", "Tool": "Yes", "Supporting Link": "https://data.mendeley.com/datasets/d87vg86zd8,https://data.mendeley.com/datasets/d87vg86zd8", "Supporting Link Description": "All image data, single cell data, and tissue feature data, is located in a public Mendeley data repository^^^Analysis code for MATLAB, R, and Python is available at the Mendeley data and code repository", "Publication-associated HTAN Parent Data File ID": [ "HTA6_0_7", "HTA6_1002_358", "HTA6_1002_359", "HTA6_1009_56", "HTA6_1010_54", "HTA6_1022_358", "HTA6_1022_359", "HTA6_1025_312", "HTA6_1028_52", "HTA6_1029_55", "HTA6_1032_414", "HTA6_1032_415", "HTA6_1033_313", "HTA6_1038_312", "HTA6_1039_312", "HTA6_1042_312", "HTA6_1044_312", "HTA6_1045_52", "HTA6_1048_313", "HTA6_1054_418", "HTA6_1054_419", "HTA6_1057_310", "HTA6_1060_312", "HTA6_1064_312", "HTA6_1066_312", "HTA6_1073_310", "HTA6_1077_316", "HTA6_1079_312", "HTA6_1081_310", "HTA6_1082_312", "HTA6_1083_310", "HTA6_1084_312", "HTA6_1085_414", "HTA6_1085_415", "HTA6_1086_310", "HTA6_1089_316", "HTA6_1092_312", "HTA6_1095_312", "HTA6_1098_417", "HTA6_1098_418", "HTA6_1102_312", "HTA6_1118_369", "HTA6_1127_314", "HTA6_1133_312", "HTA6_1134_312", "HTA6_1135_316", "HTA6_1136_316", "HTA6_1151_312", "HTA6_1152_311", "HTA6_1156_365", "HTA6_1159_413", "HTA6_1159_414", "HTA6_1160_314", "HTA6_1164_310", "HTA6_1165_412", "HTA6_1165_413", "HTA6_1166_312", "HTA6_2020_413", "HTA6_2020_414", "HTA6_2023_314", "HTA6_2026_310", "HTA6_2029_312", "HTA6_2038_310", "HTA6_2048_310", "HTA6_2055_310", "HTA6_2071_318", "HTA6_2074_312", "HTA6_2077_318", "HTA6_2078_312", "HTA6_2129_56", "HTA6_2130_50", "HTA6_2327_46", "HTA6_2350_50", "HTA6_EXT1_45", "HTA6_EXT2_45", "HTA6_EXT3_45", "HTA6_EXT4_45", "HTA6_EXT5_45", "HTA6_EXT6_45", "HTA6_EXT7_45" ], "Eutils Date": "2022 Jan 20", "Eutils Title": "Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.", "Eutils Journal": "Cell", "Eutils Sort Date": "2022/01/20 00:00", "Eutils Authors": "Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Guti\u00e9rrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M", "Eutils DOI": "10.1016/j.cell.2021.12.023", "Cited In Number": 217, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=35063072" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233254", "HTAN Center ID": "HTA6", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.ccell.2022.10.021", "Title": "Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts", "Authors": "Siri H Strand, Bel\u00e9n Rivero-Guti\u00e9rrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden A Simpson, Sujay Vennam, Aziz Khan, Luis Cisneros, Timothy Hardman, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair M Thompson, Gaorav P Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Lauren Anderson, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West", "Corresponding Author": "E Shelley Hwang, Robert B West", "Corresponding Author ORCID": "https://orcid.org/0000-0002-8571-1148,https://orcid.org/orcid-search/search?searchQuery=0000-0002-8330-8283", "Year of Publication": "2022", "Location of Publication": "Cancer Cell", "Publication Abstract": "Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions are identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/36400020/", "Publication contains HTAN ID": "No", "Data Type": "MIBI,Bulk DNA,Bulk RNA-seq,H&E", "Tool": "No", "Supporting Link": "https://data.mendeley.com/datasets/tbzv5hpvw5/1", "Supporting Link Description": "All original code has been deposited at Mendeley Data and is publicly available as of the date of publication.", "Publication-associated HTAN Parent Data File ID": [ "HTA6_0_1", "HTA6_0_2", "HTA6_0_3", "HTA6_0_4", "HTA6_0_5", "HTA6_0_6", "HTA6_1001_5", "HTA6_1001_6", "HTA6_1001_7", "HTA6_1001_8", "HTA6_1002_266", "HTA6_1002_267", "HTA6_1002_270", "HTA6_1002_271", "HTA6_1004_5", "HTA6_1004_6", "HTA6_1004_7", "HTA6_1004_8", "HTA6_1005_5", "HTA6_1005_6", 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"HTA6_83_22", "HTA6_83_23", "HTA6_84_20", "HTA6_84_21", "HTA6_85_20", "HTA6_85_21", "HTA6_86_26", "HTA6_86_27", "HTA6_87_4", "HTA6_87_5", "HTA6_88_18", "HTA6_88_19", "HTA6_89_5", "HTA6_89_6", "HTA6_8_5", "HTA6_8_6", "HTA6_90_16", "HTA6_90_17", "HTA6_92_25", "HTA6_92_26", "HTA6_93_5", "HTA6_93_6", "HTA6_94_18", "HTA6_94_19", "HTA6_95_18", "HTA6_95_19", "HTA6_96_5", "HTA6_96_6", "HTA6_97_22", "HTA6_97_23", "HTA6_98_14", "HTA6_98_15", "HTA6_99_33", "HTA6_99_34", "HTA6_9_16", "HTA6_9_17" ], "Eutils Date": "2022 Dec 12", "Eutils Title": "Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts.", "Eutils Journal": "Cancer cell", "Eutils Sort Date": "2022/12/12 00:00", "Eutils Authors": "Strand SH, Rivero-Guti\u00e9rrez B, Houlahan KE, Seoane JA, King LM, Risom T, Simpson LA, Vennam S, Khan A, Cisneros L, Hardman T, Harmon B, Couch F, Gallagher K, Kilgore M, Wei S, DeMichele A, King T, McAuliffe PF, Nangia J, Lee J, Tseng J, Storniolo AM, Thompson AM, Gupta GP, Burns R, Veis DJ, DeSchryver K, Zhu C, Matusiak M, Wang J, Zhu SX, Tappenden J, Ding DY, Zhang D, Luo J, Jiang S, Varma S, Anderson L, Straub C, Srivastava S, Curtis C, Tibshirani R, Angelo RM, Hall A, Owzar K, Polyak K, Maley C, Marks JR, Colditz GA, Hwang ES, West RB", "Eutils DOI": "10.1016/j.ccell.2022.10.021", "Cited In Number": 53, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=36400020" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233254", "HTAN Center ID": "HTA6", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1186/s13058-024-01885-8", "Title": "Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome", "Authors": "Siri H. Strand, Kathleen E. Houlahan, Vernal Branch, Thomas Lynch, Bel\u00e9n Rivero-Guiti\u00e9rrez, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla McAuliffe, Christina Curtis, Kouros Owzar, Jeffrey R. Marks, Graham A. Colditz, E. Shelley Hwang & Robert B. West", "Corresponding Author": "Robert B West", "Corresponding Author ORCID": "https://orcid.org/orcid-search/search?searchQuery=0000-0002-8330-8283", "Year of Publication": "2024", "Location of Publication": "Breast Cancer Research", "Publication Abstract": "Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated. We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up. Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups. Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39223670/", "Publication contains HTAN ID": "", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA6_1012_12", "HTA6_1015_12", "HTA6_2129_12", "HTA6_1043_12", "HTA6_1036_12", "HTA6_1054_331", "HTA6_2014_276", "HTA6_1053_272", "HTA6_1050_15", "HTA6_2118_12", "HTA6_1136_272", "HTA6_1135_272", "HTA6_1147_12", "HTA6_2077_274", "HTA6_1077_272", "HTA6_2071_274", "HTA6_1098_330", "HTA6_1097_10", "HTA6_1067_12", "HTA6_1065_12", "HTA6_1072_329", "HTA6_1080_12", "HTA6_1089_272", "HTA6_2306_14", "HTA6_2157_10", "HTA6_2156_10", "HTA6_2317_10", "HTA6_2256_12", "HTA6_2135_12", "HTA6_2360_14", "HTA6_2384_12", "HTA6_2383_12", "HTA6_2166_10", "HTA6_2402_12", "HTA6_2203_12", "HTA6_2411_8", "HTA6_2412_8", "HTA6_2413_8", "HTA6_2414_8", 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"HTA6_2493_2", "HTA6_2179_7", "HTA6_2157_4", "HTA6_79_4", "HTA6_71_18", "HTA6_2372_5", "HTA6_2436_2", "HTA6_2129_5", "HTA6_35_5", "HTA6_2418_2", "HTA6_48_5", "HTA6_66_41", "HTA6_2156_4", "HTA6_2267_3", "HTA6_65_23", "HTA6_2437_2", "HTA6_157_16", "HTA6_2485_2", "HTA6_1136_267", "HTA6_2487_2", "HTA6_70_4", "HTA6_153_18", "HTA6_2459_2", "HTA6_97_22", "HTA6_2472_2", "HTA6_94_18", "HTA6_159_18", "HTA6_167_27", "HTA6_106_35", "HTA6_60_21", "HTA6_122_16", "HTA6_2460_2", "HTA6_2480_2", "HTA6_1125_11", "HTA6_2360_7", "HTA6_27_21", "HTA6_45_16", "HTA6_88_18", "HTA6_128_4", "HTA6_147_20", "HTA6_84_20", "HTA6_2474_2", "HTA6_2469_2", "HTA6_141_20", "HTA6_9_16", "HTA6_1036_7", "HTA6_2462_2", "HTA6_2446_2", "HTA6_3_39", "HTA6_51_4", "HTA6_2464_2", "HTA6_1072_324", "HTA6_29_5", "HTA6_19_18", "HTA6_2491_2", "HTA6_130_17", "HTA6_161_22", "HTA6_69_22", "HTA6_109_37", "HTA6_2165_3", "HTA6_56_4", "HTA6_98_14", "HTA6_1135_267", "HTA6_1065_7", "HTA6_2355_5", "HTA6_170_16", "HTA6_96_5", "HTA6_2014_269", "HTA6_133_4", "HTA6_2439_2", "HTA6_2218_3", "HTA6_80_4", "HTA6_2466_2", "HTA6_82_22", "HTA6_26_18", "HTA6_2454_2", "HTA6_2430_2", "HTA6_62_18", "HTA6_113_27", "HTA6_2445_2", "HTA6_58_5", "HTA6_2396_3", "HTA6_83_22", "HTA6_2381_3", "HTA6_1043_7", "HTA6_2118_5", "HTA6_2476_2", "HTA6_4_31", "HTA6_2452_2", "HTA6_61_18", "HTA6_72_4", "HTA6_86_26", "HTA6_2268_4", "HTA6_12_5", "HTA6_119_14", "HTA6_2208_3", "HTA6_90_16", "HTA6_2471_2", "HTA6_2488_2", "HTA6_156_6", "HTA6_2203_5", "HTA6_34_27", "HTA6_68_43", "HTA6_2417_2", "HTA6_2451_2", "HTA6_2423_2", "HTA6_7_28", "HTA6_28_4", "HTA6_55_4", "HTA6_2207_3", "HTA6_76_20", "HTA6_77_5", "HTA6_31_18", "HTA6_20_18", "HTA6_40_14", "HTA6_1122_6", "HTA6_2212_3", "HTA6_118_20", "HTA6_2463_2", "HTA6_1080_7", "HTA6_2419_2", "HTA6_116_24", "HTA6_67_14", "HTA6_75_20", "HTA6_168_24", "HTA6_2166_4", "HTA6_2410_22", "HTA6_46_18", "HTA6_81_12", "HTA6_2425_2", "HTA6_2353_3", "HTA6_2317_4", "HTA6_2176_3", "HTA6_117_21", "HTA6_2444_2", "HTA6_154_18", "HTA6_2438_2", "HTA6_2254_7", "HTA6_2402_5", "HTA6_2412_2", "HTA6_1054_326", "HTA6_85_20", "HTA6_158_18", "HTA6_2424_2", "HTA6_41_22", "HTA6_169_16", "HTA6_2456_2", "HTA6_110_29", "HTA6_104_5", "HTA6_2492_2", "HTA6_151_25", "HTA6_2434_2", "HTA6_36_27", "HTA6_1053_267", "HTA6_2113_3", "HTA6_2281_3", "HTA6_1147_7", "HTA6_2489_2", "HTA6_2071_267", "HTA6_138_19", "HTA6_140_22", "HTA6_2_16", "HTA6_115_27", "HTA6_166_27", "HTA6_2455_2", "HTA6_107_20", "HTA6_50_5", "HTA6_2414_2", "HTA6_2383_5", "HTA6_2169_3", "HTA6_114_21", "HTA6_2428_2", "HTA6_2384_5", "HTA6_2470_2", "HTA6_92_25", "HTA6_1015_7", "HTA6_30_20", "HTA6_2433_2", "HTA6_87_4", "HTA6_1050_10", "HTA6_2448_2", "HTA6_1089_267", "HTA6_2302_3", "HTA6_54_6", "HTA6_1077_267", "HTA6_2435_2", "HTA6_47_18", "HTA6_16_4", "HTA6_112_14", "HTA6_2214_3", "HTA6_2077_267", "HTA6_144_16", "HTA6_143_20", "HTA6_10_4", "HTA6_2256_6", "HTA6_145_16", "HTA6_1098_325", "HTA6_2209_5", "HTA6_2483_2", "HTA6_37_18", "HTA6_32_18", "HTA6_2420_2", "HTA6_127_5", "HTA6_2145_3", "HTA6_2475_2", "HTA6_1012_7", "HTA6_2292_4", "HTA6_2185_3", "HTA6_2431_2", "HTA6_2422_2", "HTA6_44_4", "HTA6_63_41", "HTA6_2490_2", "HTA6_2135_5", "HTA6_139_23", "HTA6_2467_2", "HTA6_39_5", "HTA6_126_18", "HTA6_142_21", "HTA6_2427_2", "HTA6_2486_2", "HTA6_1067_7", "HTA6_129_5", "HTA6_2468_2", "HTA6_125_18", "HTA6_33_18", "HTA6_2441_2", "HTA6_22_23", "HTA6_1097_6", "HTA6_100_19", "HTA6_2457_2", "HTA6_160_19", "HTA6_2458_2", "HTA6_131_5", "HTA6_137_21", "HTA6_2440_2", "HTA6_2484_2", "HTA6_21_15", "HTA6_2426_2", "HTA6_2477_2", "HTA6_2115_3", "HTA6_2461_2", "HTA6_2449_2", "HTA6_155_4", "HTA6_2413_2", "HTA6_124_16", "HTA6_2183_3", "HTA6_136_16", "HTA6_2442_2", "HTA6_2429_2", "HTA6_64_27", "HTA6_15_5", "HTA6_13_16", "HTA6_14_26", "HTA6_2415_2", "HTA6_2473_2", "HTA6_2416_2", "HTA6_2348_3", "HTA6_25_16", "HTA6_8_5", "HTA6_2421_2", "HTA6_2478_2", "HTA6_38_5", "HTA6_73_4", "HTA6_53_4", "HTA6_2213_3", "HTA6_152_4", "HTA6_2482_2", "HTA6_18_4", "HTA6_1012_3", "HTA6_1012_2", "HTA6_1015_3", "HTA6_1015_2", "HTA6_2129_6", "HTA6_2129_7", "HTA6_1043_3", "HTA6_1043_2", "HTA6_1036_3", "HTA6_1036_2", "HTA6_1054_6", "HTA6_1054_3", "HTA6_2014_270", "HTA6_2014_271", "HTA6_1053_4", "HTA6_1053_2", "HTA6_1050_4", "HTA6_1050_2", "HTA6_2118_6", "HTA6_2118_7", "HTA6_1136_3", "HTA6_1136_2", "HTA6_1135_3", "HTA6_1135_2", "HTA6_1147_3", "HTA6_1147_2", "HTA6_2077_268", "HTA6_2077_269", "HTA6_1077_3", "HTA6_1077_2", "HTA6_2071_268", "HTA6_2071_269", "HTA6_1098_6", "HTA6_1098_3", "HTA6_1097_3", "HTA6_1097_2", "HTA6_1067_3", "HTA6_1067_2", "HTA6_1065_3", "HTA6_1065_2", "HTA6_1072_5", "HTA6_1072_3", "HTA6_1080_3", "HTA6_1080_2", "HTA6_1089_3", "HTA6_1089_2", "HTA6_2306_8", "HTA6_2306_9", "HTA6_2157_5", "HTA6_2157_6", "HTA6_2156_5", "HTA6_2156_6", "HTA6_2317_5", "HTA6_2317_6", "HTA6_2256_7", "HTA6_2256_8", "HTA6_2135_6", "HTA6_2135_7", "HTA6_2360_8", "HTA6_2360_9", "HTA6_2384_6", "HTA6_2384_7", "HTA6_2383_6", "HTA6_2383_7", "HTA6_2166_5", "HTA6_2166_6", "HTA6_2402_6", "HTA6_2402_7", "HTA6_2203_6", "HTA6_2203_7", "HTA6_2411_3", "HTA6_2411_4", "HTA6_2412_3", "HTA6_2412_4", "HTA6_2413_3", "HTA6_2413_4", "HTA6_2414_3", "HTA6_2414_4", "HTA6_2415_3", "HTA6_2415_4", "HTA6_2416_3", "HTA6_2416_4", "HTA6_2417_3", "HTA6_2417_4", "HTA6_2418_3", "HTA6_2418_4", "HTA6_2419_3", "HTA6_2419_4", "HTA6_2420_3", "HTA6_2420_4", "HTA6_2421_3", "HTA6_2421_4", "HTA6_2422_3", "HTA6_2422_4", "HTA6_2423_3", "HTA6_2423_4", "HTA6_2424_3", "HTA6_2424_4", "HTA6_2425_3", "HTA6_2425_4", "HTA6_2426_3", "HTA6_2426_4", "HTA6_2427_3", "HTA6_2427_4", "HTA6_2428_3", "HTA6_2428_4", "HTA6_2429_3", "HTA6_2429_4", "HTA6_2430_3", "HTA6_2430_4", "HTA6_2431_3", "HTA6_2431_4", "HTA6_2432_3", "HTA6_2432_4", "HTA6_2433_3", "HTA6_2433_4", "HTA6_2434_3", "HTA6_2434_4", "HTA6_2435_3", "HTA6_2435_4", "HTA6_2436_3", "HTA6_2436_4", "HTA6_2437_3", "HTA6_2437_4", "HTA6_2438_3", "HTA6_2438_4", "HTA6_2439_3", "HTA6_2439_4", "HTA6_2440_3", "HTA6_2440_4", "HTA6_2441_3", "HTA6_2441_4", "HTA6_2442_3", "HTA6_2442_4", "HTA6_1_4", "HTA6_1_2", "HTA6_1_5", "HTA6_1_3", "HTA6_10_3", "HTA6_10_2", "HTA6_104_3", "HTA6_104_2", "HTA6_106_13", "HTA6_106_6", "HTA6_106_14", "HTA6_106_7", "HTA6_107_5", "HTA6_107_3", "HTA6_109_13", "HTA6_109_7", "HTA6_109_14", "HTA6_109_8", "HTA6_109_15", "HTA6_109_9", "HTA6_11_10", "HTA6_11_6", "HTA6_110_10", "HTA6_110_5", "HTA6_112_6", "HTA6_112_4", "HTA6_113_9", "HTA6_113_6", "HTA6_114_7", "HTA6_114_4", "HTA6_115_9", "HTA6_115_6", "HTA6_116_6", "HTA6_116_3", "HTA6_117_8", "HTA6_117_5", "HTA6_118_6", "HTA6_118_4", "HTA6_119_3", "HTA6_119_2", "HTA6_12_3", "HTA6_12_2", "HTA6_122_6", "HTA6_122_4", "HTA6_124_6", "HTA6_124_4", "HTA6_125_7", "HTA6_125_4", "HTA6_126_6", "HTA6_126_4", "HTA6_127_3", "HTA6_127_2", "HTA6_128_3", "HTA6_128_2", "HTA6_129_3", "HTA6_129_2", "HTA6_13_8", "HTA6_13_5", "HTA6_130_3", "HTA6_130_2", "HTA6_131_3", "HTA6_131_2", "HTA6_132_3", "HTA6_132_2", "HTA6_133_3", "HTA6_133_2", "HTA6_134_5", "HTA6_134_3", "HTA6_136_5", "HTA6_136_3", "HTA6_137_9", "HTA6_137_6", "HTA6_138_9", "HTA6_138_6", "HTA6_139_9", "HTA6_139_6", "HTA6_14_5", "HTA6_14_3", "HTA6_140_9", "HTA6_140_4", "HTA6_141_8", "HTA6_141_5", "HTA6_142_10", "HTA6_142_6", "HTA6_143_8", "HTA6_143_5", "HTA6_144_8", "HTA6_144_5", "HTA6_145_9", "HTA6_145_6", "HTA6_147_6", "HTA6_147_4", "HTA6_15_3", "HTA6_15_2", "HTA6_151_9", "HTA6_151_6", "HTA6_152_3", "HTA6_152_2", "HTA6_153_6", "HTA6_153_4", "HTA6_154_5", "HTA6_154_3", "HTA6_155_3", "HTA6_155_2", "HTA6_156_4", "HTA6_156_2", "HTA6_156_5", "HTA6_156_3", "HTA6_157_5", "HTA6_157_3", "HTA6_158_7", "HTA6_158_4", "HTA6_159_5", "HTA6_159_3", "HTA6_16_3", "HTA6_16_2", "HTA6_160_9", "HTA6_160_6", "HTA6_161_7", "HTA6_161_4", "HTA6_165_6", "HTA6_165_4", "HTA6_166_9", "HTA6_166_5", "HTA6_167_9", "HTA6_167_6", "HTA6_168_6", "HTA6_168_4", "HTA6_169_6", "HTA6_169_4", "HTA6_17_3", "HTA6_17_2", "HTA6_170_6", "HTA6_170_4", "HTA6_18_3", "HTA6_18_2", "HTA6_19_3", "HTA6_19_2", "HTA6_2_7", "HTA6_2_4", "HTA6_20_9", "HTA6_20_5", "HTA6_21_6", "HTA6_21_4", "HTA6_24_3", "HTA6_24_2", "HTA6_25_3", "HTA6_25_2", "HTA6_26_3", "HTA6_26_2", "HTA6_27_7", "HTA6_27_4", "HTA6_28_3", "HTA6_28_2", "HTA6_29_3", "HTA6_29_2", "HTA6_3_9", "HTA6_3_4", "HTA6_30_7", "HTA6_30_4", "HTA6_31_8", "HTA6_31_5", "HTA6_32_3", "HTA6_32_2", "HTA6_33_9", "HTA6_33_5", "HTA6_34_7", "HTA6_34_4", "HTA6_35_3", "HTA6_35_2", "HTA6_36_16", "HTA6_36_9", "HTA6_36_17", "HTA6_36_10", "HTA6_36_18", "HTA6_36_11", "HTA6_37_8", "HTA6_37_4", "HTA6_38_3", "HTA6_38_2", "HTA6_39_3", "HTA6_39_2", "HTA6_4_17", "HTA6_4_8", "HTA6_4_18", "HTA6_4_9", "HTA6_4_22", "HTA6_4_13", "HTA6_40_3", "HTA6_40_2", "HTA6_41_5", "HTA6_41_3", "HTA6_43_6", "HTA6_43_4", "HTA6_44_3", "HTA6_44_2", "HTA6_45_3", "HTA6_45_2", "HTA6_46_5", "HTA6_46_3", "HTA6_47_7", "HTA6_47_4", "HTA6_48_3", "HTA6_48_2", "HTA6_50_3", "HTA6_50_2", "HTA6_51_3", "HTA6_51_2", "HTA6_53_3", "HTA6_53_2", "HTA6_54_4", "HTA6_54_2", "HTA6_54_5", "HTA6_54_3", "HTA6_55_3", "HTA6_55_2", "HTA6_56_3", "HTA6_56_2", "HTA6_58_3", "HTA6_58_2", "HTA6_59_9", "HTA6_59_5", "HTA6_6_3", "HTA6_6_2", "HTA6_60_7", "HTA6_60_4", "HTA6_61_5", "HTA6_61_3", "HTA6_62_8", "HTA6_62_5", "HTA6_63_10", "HTA6_63_4", "HTA6_65_7", "HTA6_65_4", "HTA6_66_12", "HTA6_66_5", "HTA6_66_13", "HTA6_66_6", "HTA6_66_16", "HTA6_66_9", "HTA6_67_5", "HTA6_67_3", "HTA6_68_16", "HTA6_68_8", "HTA6_68_17", "HTA6_68_9", "HTA6_68_19", "HTA6_68_11", "HTA6_69_5", "HTA6_69_3", "HTA6_7_8", "HTA6_7_5", "HTA6_70_3", "HTA6_70_2", "HTA6_71_5", "HTA6_71_3", "HTA6_72_3", "HTA6_72_2", "HTA6_73_3", "HTA6_73_2", "HTA6_74_3", "HTA6_74_2", "HTA6_75_5", "HTA6_75_3", "HTA6_76_6", "HTA6_76_4", "HTA6_77_3", "HTA6_77_2", "HTA6_79_3", "HTA6_79_2", "HTA6_8_3", "HTA6_8_2", "HTA6_80_3", "HTA6_80_2", "HTA6_81_3", "HTA6_81_2", "HTA6_82_6", "HTA6_82_4", "HTA6_83_5", "HTA6_83_3", "HTA6_84_5", "HTA6_84_3", "HTA6_85_5", "HTA6_85_3", "HTA6_86_6", "HTA6_86_4", "HTA6_87_3", "HTA6_87_2", "HTA6_88_5", "HTA6_88_3", "HTA6_9_3", "HTA6_9_2", "HTA6_90_8", "HTA6_90_5", "HTA6_92_10", "HTA6_92_6", "HTA6_93_3", "HTA6_93_2", "HTA6_94_8", "HTA6_94_5", "HTA6_95_8", "HTA6_95_5", "HTA6_96_3", "HTA6_96_2", "HTA6_97_7", "HTA6_97_4", "HTA6_98_5", "HTA6_98_3", "HTA6_99_12", "HTA6_99_4", "HTA6_99_13", "HTA6_99_5", "HTA6_0_3", "HTA6_0_4", "HTA6_0_5", "HTA6_0_6" ], "Eutils Date": "2024 Sep 2", "Eutils Title": "Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.", "Eutils Journal": "Breast cancer research : BCR", "Eutils Sort Date": "2024/09/02 00:00", "Eutils Authors": "Strand SH, Houlahan KE, Branch V, King LM, Lynch T, Rivero-Guiti\u00e9rrez B, Harmon B, Couch F, Gallagher K, Kilgore M, Wei S, DeMichele A, King T, McAuliffe P, Curtis C, Owzar K, Marks JR, Colditz GA, Hwang ES, West RB", "Eutils DOI": "10.1186/s13058-024-01885-8", "Cited In Number": 6, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39223670" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233262", "HTAN Center ID": "HTA7", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.cell.2022.12.028", "Title": "Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer", "Authors": "Jia-Ren Lin, Shu Wang, Shannon Coy, Yu-An Chen, Clarence Yapp, Madison Tyler, Maulik K Nariya, Cody N Heiser, Ken S Lau, Sandro Santagata, Peter K Sorger", "Corresponding Author": "Peter K Sorger", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3364-1838", "Year of Publication": "2022", "Location of Publication": "Cell", "Publication Abstract": "Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D reconstruction, spatial statistics, and machine learning to identify cell types and states underlying morphological features of known diagnostic and prognostic significance in colorectal cancer. Quantitation of these features in high-plex marker space reveals recurrent transitions from one tumor morphology to the next, some of which are coincident with long-range gradients in the expression of oncogenes and epigenetic regulators. At the tumor invasive margin, where tumor, normal, and immune cells compete, T cell suppression involves multiple cell types and 3D imaging shows that seemingly localized 2D features such as tertiary lymphoid structures are commonly interconnected and have graded molecular properties. Thus, while cancer genetics emphasizes the importance of discrete changes in tumor state, whole-specimen imaging reveals large-scale morphological and molecular gradients analogous to those in developing tissues.", "License": "CC-BY-NC-ND-4.0)", "PMID": "https://pubmed.ncbi.nlm.nih.gov/36669472/", "Publication contains HTAN ID": "No", "Data Type": "CODEX,CyCIF,H&E,Imaging,SABER,mIHC,RareCyte Orion", "Tool": "Yes", "Supporting Link": "https://github.com/labsyspharm/mcmicro,https://github.com/labsyspharm/minerva-story,https://github.com/labsyspharm/CRC_atlas_2022,https://www.tissue-atlas.org/atlas-datasets/lin-wang-coy-2021/,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE166319,https://github.com/labsyspharm/CRC_atlas_2022", "Supporting Link Description": "MCMICRO pipeline (de0d76d7cf0870f1ed979722a465de0fc246b90b)^^^Minerva Story^^^A version of this data with additional annotations and visualizations^^^Several of the figure panels in this paper are available with text and audio narration for anonymous on-line browsing using MINERVA software,(Rashid et al.)34 as are images of CRC2\u201317^^^scRNA-seq data is available in the Gene Expression Omnibus (GEO accession: GSE166319)^^^All software used in this manuscript is freely available via GitHub", "Publication-associated HTAN Parent Data File ID": [ "HTA13_1_7002", "HTA13_1_7044", "HTA13_1_7045", "HTA13_1_7749", "HTA13_1_7774", "HTA13_1_7046", "HTA13_1_7047", "HTA13_1_7750", "HTA13_1_7775", "HTA13_1_7048", "HTA13_1_7003", "HTA13_1_7728", "HTA13_1_7753", "HTA13_1_7049", "HTA13_1_7751", "HTA13_1_7776", "HTA13_1_7725", "HTA13_1_7726", "HTA13_1_5130", "HTA13_1_5133", "HTA13_1_5134", "HTA13_1_9138", "HTA13_1_9139", "HTA13_1_9140", "HTA13_1_9141", "HTA13_1_9142", "HTA13_1_9143", "HTA13_1_9144", "HTA13_1_9145", "HTA13_1_9146", "HTA13_1_9147", "HTA13_1_9148", "HTA13_1_9149", "HTA13_1_9150", "HTA13_1_9050", "HTA13_1_9051", "HTA13_1_9052", "HTA13_1_9053", "HTA13_1_9054", "HTA13_1_9055", "HTA13_1_9056", "HTA13_1_9057", 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Date": "2023 Jan 19", "Eutils Title": "Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer.", "Eutils Journal": "Cell", "Eutils Sort Date": "2023/01/19 00:00", "Eutils Authors": "Lin JR, Wang S, Coy S, Chen YA, Yapp C, Tyler M, Nariya MK, Heiser CN, Lau KS, Santagata S, Sorger PK", "Eutils DOI": "10.1016/j.cell.2022.12.028", "Cited In Number": 176, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=36669472" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233262", "HTAN Center ID": "HTA7", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1158/2159-8290.cd-21-1357", "Title": "The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution", "Authors": "Ajit J Nirmal, Zoltan Maliga, Tuulia Vallius, Brian Quattrochi, Alyce A Chen, Connor A Jacobson, Roxanne J Pelletier, Clarence Yapp, Raquel Arias-Camison, Yu-An Chen, Christine G Lian, George F Murphy, Sandro Santagata, Peter K Sorger", "Corresponding Author": "Peter K Sorger", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3364-1838", "Year of Publication": "2022", "Location of Publication": "Cancer Discovery", "Publication Abstract": "Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high-resolution microscopy, and spatially resolved microregion transcriptomics to study immune evasion and immunoediting in primary melanoma. We find that recurrent cellular neighborhoods involving tumor, immune, and stromal cells change significantly along a progression axis involving precursor states, melanoma in situ, and invasive tumor. Hallmarks of immunosuppression are already detectable in precursor regions. When tumors become locally invasive, a consolidated and spatially restricted suppressive environment forms along the tumor-stromal boundary. This environment is established by cytokine gradients that promote expression of MHC-II and IDO1, and by PD1-PDL1-mediated cell contacts involving macrophages, dendritic cells, and T cells. A few millimeters away, cytotoxic T cells synapse with melanoma cells in fields of tumor regression. Thus, invasion and immunoediting can coexist within a few millimeters of each other in a single specimen.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/35404441/", "Publication contains HTAN ID": "Yes", "Data Type": "Bulk RNA-seq,H&E,CyCIF", "Tool": "Yes", "Supporting Link": "https://github.com/labsyspharm/mcmicro,https://github.com/labsyspharm/cycif_viewer,https://www.tissue-atlas.org/atlas-datasets/nirmal-maliga-vallius-2021/", "Supporting Link Description": "MCMICRO pipeline^^^OpenSeadragon-based visual gating tool^^^Data are also available via the Harvard Tissue Atlas Portal", "Publication-associated HTAN Parent Data File ID": [ "HTA7_10_1000", "HTA7_10_1001", "HTA7_10_1002", "HTA7_10_1003", "HTA7_10_1004", "HTA7_13_1000", "HTA7_13_1001", "HTA7_13_1002", "HTA7_13_1003", "HTA7_13_1004", "HTA7_14_1000", "HTA7_14_1001", "HTA7_14_1002", "HTA7_14_1003", "HTA7_15_1000", "HTA7_15_1001", "HTA7_15_1002", "HTA7_15_1003", "HTA7_15_1004", "HTA7_16_1000", 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"HTA7_1_1260", "HTA7_1_1261", "HTA7_1_1262", "HTA7_1_1263", "HTA7_1_1264", "HTA7_1_1265", "HTA7_1_1266", "HTA7_1_1267", "HTA7_1_1268", "HTA7_1_1269", "HTA7_1_1270", "HTA7_1_1271", "HTA7_1_1272", "HTA7_1_1273", "HTA7_1_1274", "HTA7_1_1275", "HTA7_1_1276", "HTA7_1_1277", "HTA7_1_1278", "HTA7_1_1279", "HTA7_1_1280", "HTA7_1_1281", "HTA7_1_1282", "HTA7_1_1283", "HTA7_1_1284", "HTA7_1_1285", "HTA7_1_1286", "HTA7_1_1287", "HTA7_1_1288", "HTA7_1_1289", "HTA7_1_1290", "HTA7_1_1291", "HTA7_1_1292", "HTA7_1_1293", "HTA7_1_1294", "HTA7_1_1295", "HTA7_1_1296", "HTA7_1_1297", "HTA7_1_1298", "HTA7_1_1299", "HTA7_1_1300", "HTA7_1_1301", "HTA7_1_1302", "HTA7_1_1303", "HTA7_1_1304", "HTA7_1_1305", "HTA7_1_1306", "HTA7_1_1307", "HTA7_1_1308", "HTA7_1_1309", "HTA7_1_1310", "HTA7_1_1311", "HTA7_1_1312", "HTA7_1_1313", "HTA7_1_1314", "HTA7_1_1315", "HTA7_1_1316", "HTA7_1_1317", "HTA7_1_1318", "HTA7_1_1319", "HTA7_1_1320", "HTA7_1_1321", "HTA7_1_1322", "HTA7_1_1323", "HTA7_1_1324", "HTA7_1_1325", 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"HTA7_1_1458", "HTA7_1_1459", "HTA7_1_1460", "HTA7_1_1461", "HTA7_1_1462", "HTA7_1_1463", "HTA7_1_1464", "HTA7_1_1465", "HTA7_1_1466", "HTA7_1_1467", "HTA7_1_1468", "HTA7_1_1469", "HTA7_1_1470", "HTA7_1_1471", "HTA7_1_1472", "HTA7_1_1473", "HTA7_1_1474", "HTA7_1_1475", "HTA7_1_1476", "HTA7_1_1477", "HTA7_1_1478", "HTA7_1_1479", "HTA7_1_1480", "HTA7_1_1481", "HTA7_1_1482", "HTA7_1_1483", "HTA7_1_1484", "HTA7_1_1485", "HTA7_1_1486", "HTA7_1_1487", "HTA7_1_1488", "HTA7_1_1489", "HTA7_1_1490", "HTA7_1_1491", "HTA7_1_1492", "HTA7_1_1493", "HTA7_1_1494", "HTA7_1_1495", "HTA7_1_1496", "HTA7_1_1497", "HTA7_1_1498", "HTA7_1_1499", "HTA7_1_1500", "HTA7_1_1501", "HTA7_1_1502", "HTA7_1_1503", "HTA7_1_1504", "HTA7_1_1505", "HTA7_1_1506", "HTA7_1_1507", "HTA7_1_1508", "HTA7_1_1509", "HTA7_1_1510", "HTA7_1_1511", "HTA7_1_1512", "HTA7_1_1513", "HTA7_1_1514", "HTA7_1_1515", "HTA7_1_1516", "HTA7_1_1517", "HTA7_1_1518", "HTA7_1_1519", "HTA7_1_1520", "HTA7_1_1521", "HTA7_1_1522", "HTA7_1_1523", "HTA7_1_1524", "HTA7_1_1525", "HTA7_1_1526", "HTA7_1_1527", "HTA7_1_1528", "HTA7_1_1529", "HTA7_1_1530", "HTA7_1_1531", "HTA7_1_1532", "HTA7_1_1533", "HTA7_1_1534", "HTA7_1_1535", "HTA7_1_1536", "HTA7_1_1537", "HTA7_1_1538", "HTA7_1_1539", "HTA7_1_1540", "HTA7_1_1541", "HTA7_1_1542", "HTA7_1_1543", "HTA7_1_1544", "HTA7_1_1545", "HTA7_1_1546", "HTA7_1_1547", "HTA7_1_1548", "HTA7_1_1549", "HTA7_1_1550", "HTA7_1_1551", "HTA7_1_1552", "HTA7_1_1553", "HTA7_1_1554", "HTA7_1_1555", "HTA7_1_1556", "HTA7_1_1557", "HTA7_1_1558", "HTA7_1_1559", "HTA7_1_1560", "HTA7_1_1561", "HTA7_1_1562", "HTA7_1_1563", "HTA7_1_1564", "HTA7_1_1565", "HTA7_1_1566", "HTA7_1_1567", "HTA7_1_1568", "HTA7_1_1569", "HTA7_1_1570", "HTA7_1_1571", "HTA7_1_1572", "HTA7_1_1573", "HTA7_1_1574", "HTA7_1_1575", "HTA7_1_1576", "HTA7_1_1577", "HTA7_1_1578", "HTA7_1_1579", "HTA7_1_1580", "HTA7_1_1581", "HTA7_1_1582", "HTA7_1_1583", "HTA7_1_1584", "HTA7_1_1585", "HTA7_1_1586", "HTA7_1_1587", "HTA7_1_1588", "HTA7_1_1589", "HTA7_1_1590", "HTA7_1_1591", "HTA7_1_1592", "HTA7_1_1593", "HTA7_1_1594", "HTA7_1_1595", "HTA7_1_1596", "HTA7_1_1597", "HTA7_1_1598", "HTA7_1_1599", "HTA7_1_1600", "HTA7_1_1601", "HTA7_1_1602", "HTA7_1_1603", "HTA7_1_1604", "HTA7_1_1605", "HTA7_1_1606", "HTA7_1_1607", "HTA7_1_1608", "HTA7_1_1609", "HTA7_1_1610", "HTA7_1_1611", "HTA7_1_1612", "HTA7_1_1613", "HTA7_1_1614", "HTA7_1_1615", "HTA7_1_1616", "HTA7_1_1617", "HTA7_1_1618", "HTA7_1_1619", "HTA7_1_1620", "HTA7_1_1621", "HTA7_1_1622", "HTA7_1_1623", "HTA7_1_1624", "HTA7_1_1625", "HTA7_1_1626", "HTA7_1_1627", "HTA7_1_1628", "HTA7_1_1629", "HTA7_1_1630", "HTA7_1_1631", "HTA7_1_1632", "HTA7_1_1633", "HTA7_1_1634", "HTA7_1_1635", "HTA7_1_1636", "HTA7_1_1637", "HTA7_1_1638", "HTA7_1_1639", "HTA7_1_1640", "HTA7_1_1641", "HTA7_1_1642", "HTA7_1_1643", "HTA7_1_1644", "HTA7_1_1645", "HTA7_1_1646", "HTA7_1_1647", "HTA7_1_1648", "HTA7_1_1649", "HTA7_1_1650", "HTA7_1_1651", "HTA7_1_1652", "HTA7_1_1653", "HTA7_1_1654", "HTA7_1_1655", "HTA7_1_1656", "HTA7_1_1657", "HTA7_1_1658", "HTA7_1_1659", "HTA7_1_1660", "HTA7_1_1661", "HTA7_1_1662", "HTA7_1_1663", "HTA7_1_1664", "HTA7_1_1665", "HTA7_1_1666", "HTA7_1_1667", "HTA7_1_1668", "HTA7_1_1669", "HTA7_1_1670", "HTA7_1_1671", "HTA7_1_1672", "HTA7_1_1673", "HTA7_1_1674", "HTA7_1_1675", "HTA7_1_1676", "HTA7_1_1677", "HTA7_1_1678", "HTA7_1_1679", "HTA7_1_1680", "HTA7_1_1681", "HTA7_1_1682", "HTA7_1_1683", "HTA7_1_1684", "HTA7_1_1685", "HTA7_1_1686", "HTA7_1_1687", "HTA7_1_1688", "HTA7_1_1689", "HTA7_1_1690", "HTA7_1_1691", "HTA7_1_1692", "HTA7_1_1693", "HTA7_1_1694", "HTA7_1_1695", "HTA7_1_1696", "HTA7_22_1000", "HTA7_22_1001", "HTA7_22_1002", "HTA7_22_1003", "HTA7_22_1004", "HTA7_32_1000", "HTA7_32_1001", "HTA7_32_1002", "HTA7_32_1003", "HTA7_32_1004", "HTA7_47_1000", "HTA7_47_1001", "HTA7_47_1002", "HTA7_47_1003", "HTA7_47_1004", "HTA7_49_1000", "HTA7_49_1001", "HTA7_49_1002", "HTA7_49_1003", "HTA7_49_1004", "HTA7_52_1000", "HTA7_52_1001", "HTA7_52_1002", "HTA7_52_1003", "HTA7_52_1004", "HTA7_52_1005", "HTA7_52_1006", "HTA7_52_1007", "HTA7_52_1008", "HTA7_52_1009", "HTA7_6_1000", "HTA7_6_1001", "HTA7_6_1002", "HTA7_6_1003", "HTA7_6_1004", "HTA7_8_1000", "HTA7_8_1001", "HTA7_8_1002", "HTA7_8_1003", "HTA7_8_1004" ], "Eutils Date": "2022 Jun 2", "Eutils Title": "The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution.", "Eutils Journal": "Cancer discovery", "Eutils Sort Date": "2022/06/02 00:00", "Eutils Authors": "Nirmal AJ, Maliga Z, Vallius T, Quattrochi B, Chen AA, Jacobson CA, Pelletier RJ, Yapp C, Arias-Camison R, Chen YA, Lian CG, Murphy GF, Santagata S, Sorger PK", "Eutils DOI": "10.1158/2159-8290.CD-21-1357", "Cited In Number": 154, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=35404441" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233262", "HTAN Center ID": "HTA7", "Publication Content Type": "Preprint", "DOI": "https://doi.org/10.1101/2023.11.10.566670", "Title": "Multiplexed 3D Analysis of Cell Plasticity and Immune Niches in Melanoma", "Authors": "Clarence Yapp, Ajit J Nirmal, Felix Zhou, Zoltan Maliga, Paula Montero Llopis, George F Murphy, Christine G Lian, Gaudenz Danuser, Sandro Santagata, Peter K Sorger", "Corresponding Author": "Peter K Sorger", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3364-1838", "Year of Publication": "2023", "Location of Publication": "biorXiv", "Publication Abstract": "Homeostasis of normal tissues and the emergence of diseases such as cancer are controlled by changes in the proportions and states of diverse cell types, cell-cell interactions, and acellular components of the tissue microenvironment1. Spatial omics using highly multiplexed tissue profiling2 makes it possible to study these processes in situ, usually on thin, 4-5 micron thick sections (the standard histopathology format)3. Microscopy-based tissue imaging is commonly performed at a resolution sufficient to determine cell types but not detect the subtle morphological features associated with cytoskeletal reorganisation, juxtracrine signalling, or membrane trafficking4. Here we introduce a 3D imaging approach using existing instruments and reagents that is able to characterize a wide variety of organelles and structures at sub-micron scale while simultaneously quantifying millimetre-scale spatial features. We perform high-resolution 54-plex cyclic immunofluorescence (CyCIF) imaging3 on sections of primary human melanoma thick enough (30-40 microns) to fully encompass two or more layers of intact cells. In pre-invasive melanoma in situ5, 3D imaging of entire cell volumes showed that transformed melanocytic cells are plastic in state and participate in tightly localised niches of interferon signalling near sites of initial invasion into the underlying dermis. Below this layer, immune cells engaged in an unexpectedly diverse array of membrane-membrane interactions as well as looser \u201cneighbourhood\u201d associations6. These data provide new insight into the transitions occurring during early tumour formation and demonstrate the potential for phenotyping tissues at a level of detail previously restricted to cultured cells and organoids.", "License": "CC-BY-NC-ND-4.0", "PMID": "", "Publication contains HTAN ID": "Yes", "Data Type": "CyCIF", "Tool": "Yes", "Supporting Link": "https://doi.org/10.5281/zenodo.10055593,http://www.tissue-atlas.org/mel-3d-mis-2,http://github.com/labsyspharm/mel-3d-mis,https://doi.org/10.5281/zenodo.10055593", "Supporting Link Description": "All other data supporting the findings of this study are available via an index page on GitHub that has been archived on Zenodo^^^2D maximum projection of a subset of this data in Minerva (no download required)^^^Original code associated with this paper is available on GitHub^^^Original code associated with this paper is available on Zenodo", "Publication-associated HTAN Parent Data File ID": [ "HTA7_1_1000", "HTA7_1_1676", "HTA7_1_1005", "HTA7_1_1681", "HTA7_1_1006", "HTA7_1_1682", "HTA7_1_1001", "HTA7_1_1677", "HTA7_1_1002", "HTA7_1_1678", "HTA7_1_1003", "HTA7_1_1679", "HTA7_1_1004", "HTA7_1_1680", "HTA7_1_1007", "HTA7_1_1683", "HTA7_1_1008", "HTA7_1_1684" ], "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "HHSN261201500003I", "HTAN Center ID": "HTA1", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41591-024-03215-z", "Title": "A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features", "Authors": "Johanna Klughammer, Daniel L. Abravanel, \u00c5sa Segerstolpe, Timothy R. Blosser, Yury Goltsev, Yi Cui, Daniel R. Goodwin, Anubhav Sinha, Orr Ashenberg, Michal Slyper, S\u00e9bastien Vigneau, Judit Jan\u00e9\u2010Valbuena, Shahar Alon, Chiara Caraccio, Judy Chen, Ofir Cohen, Nicole Cullen, Laura K. DelloStritto, Danielle Dionne, Janet Files, Allison Frangieh, Karla Helvie, Melissa E. Hughes, Stephanie Inga, Abhay Kanodia, Ana Lako, Colin MacKichan, Simon Mages, Noa Moriel, Evan Murray, Sara Napolitano, Kyleen Nguyen, Mor Nitzan, Rebecca Ortiz, Miraj Patel, Kathleen L. Pfaff, Caroline B. M. Porter, Asaf Rotem, Sarah Strauss, Robert Strasser, Aaron R. Thorner, Madison Turner, Isaac Wakiro, Julia Waldman, Jingyi Wu, Jorge G\u00f3mez Tejeda Za\u00f1udo, Diane Zhang, Nancy U. Lin, Sara M. Tolaney, Eric P. Winer, Edward S. Boyden, Fei Chen, Garry P. Nolan, Scott J. Rodig, Xiaowei Zhuang, Orit Rozenblatt-Rosen, Bruce E. Johnson, Aviv Regev, Nikhil Wagle", "Corresponding Author": "Johanna Klughammer,Daniel L. Abravanel,Aviv Regev, Nikhil Wagle", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3628-9278,https://orcid.org/0000-0002-0129-1618,https://orcid.org/0000-0003-3293-3158,https://orcid.org/0000-0003-3332-9438", "Year of Publication": "2024", "Location of Publication": "Nature Medicine", "Publication Abstract": "Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial and cellular map of 67 tumor biopsies from 60 patients with metastatic breast cancer across diverse clinicopathological features and nine anatomic sites with detailed clinical annotations. We combined single-cell or single-nucleus RNA sequencing for all biopsies with a panel of four spatial expression assays (Slide-seq, MERFISH, ExSeq and CODEX) and H&E staining of consecutive serial sections from up to 15 of these biopsies. We leveraged the coupled measurements to provide reference points for the utility and integration of different experimental techniques and used them to assess variability in cell type composition and expression as well as emerging spatial expression characteristics across clinicopathological and methodological diversity. Finally, we assessed spatial expression and co-localization features of macrophage populations, characterized three distinct spatial phenotypes of epithelial-to-mesenchymal transition and identified expression programs associated with local T cell infiltration versus exclusion, showcasing the potential of clinically relevant discovery in such maps.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478111/", "Publication contains HTAN ID": "Yes", "Data Type": "CODEX,ExSeq,Integrated data,MERFISH,Slide-seq,scRNA-seq", "Tool": "No", "Supporting Link": "https://cellxgene.cziscience.com/collections/a96133de-e951-4e2d-ace6-59db8b3bfb1d,https://singlecell.broadinstitute.org/single_cell/study/SCP2702,https://github.com/klarman-cell-observatory/HTAPP-Pipelines/tree/master/HTAPP_MBC,https://www.10xgenomics.com/support/software/cell-ranger/latest/release-notes/cr-reference-release-notes", "Supporting Link Description": "Data presented in this work can be browsed and 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Jan\u00e9-Valbuena J, Alon S, Caraccio C, Chen J, Cohen O, Cullen N, DelloStritto LK, Dionne D, Files J, Frangieh A, Helvie K, Hughes ME, Inga S, Kanodia A, Lako A, MacKichan C, Mages S, Moriel N, Murray E, Napolitano S, Nguyen K, Nitzan M, Ortiz R, Patel M, Pfaff KL, Porter CBM, Rotem A, Strauss S, Strasser R, Thorner AR, Turner M, Wakiro I, Waldman J, Wu J, G\u00f3mez Tejeda Za\u00f1udo J, Zhang D, Lin NU, Tolaney SM, Winer EP, Boyden ES, Chen F, Nolan GP, Rodig SJ, Zhuang X, Rozenblatt-Rosen O, Johnson BE, Regev A, Wagle N", "Eutils DOI": "10.1038/s41591-024-03215-z", "Cited In Number": 38, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478111" }, { "Component": "PublicationManifest", "HTAN Grant ID": "HHSN261201500003I", "HTAN Center ID": "HTA1", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1101/2024.01.07.574538", "Title": "A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity", "Authors": "Anand G. Patel, Orr Ashenberg, Natalie B. Collins, Justina McEvoy, Melody Allensworth-James, Felipe Segato Dezem, Samantha Turk, Natalie Geiger, Wani Arjumand, Luke Zhang, \u00c5sa Segerstolpe, Sizun Jiang, Cody Ramirez, Michal Slyper, Xin Huang, Chiara Caraccio, Hongjian Jin, Heather Sheppard, Meifen Lu, Ke Xu, Ti-Cheng Chang, Brent A. Orr, Selene Koo, Abbas Shirinifard, Chia-Wei Hsu, Richard H. Chapple, Amber Shen, Michael R. Clay, Ruth G. Tatevossian, Colleen Reilly, Jaimin Patel, Marybeth Lupo, Cynthia Cline, Danielle Dionne, Caroline B.M. Porter, Julia Waldman, Yunhao Bai, Bokai Zhu, Irving Barrera, Evan Murray, S\u00e9bastien Vigneau, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Grace Grimaldi, Laura Dellostritto, Karla Helvie, Asaf Rotem, Ana Lako, Nicole Cullen, Kathleen L. Pfaff, \u00c5sa Karlstr\u00f6m, Judit Jan\u00e9-Valbuena, Ellen Todres, Aaron Thorner, Paul Geeleher, Scott J. Rodig, Xin Zhou, Bruce E. Johnson, Gang Wu, Fei Chen, Jiyang Yu, Yury Goltsev, Jasmine Plummer, Garry P. Nolan, Orit Rozenblatt-Rosen, Haitao Pan, Aviv Regev, Elizabeth Stewart, Michael A. Dyer", "Corresponding Author": "Aviv Regev", "Corresponding Author ORCID": "https://orcid.org/0000-0003-3293-3158", "Year of Publication": "2026", "Location of Publication": "Cancer Cell", "Publication Abstract": "Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage. Although cell lines derived from neuroblastoma patients have features of either adrenergic (ADRN) or mesenchymal (MES) cells, identifying MES cells in patient tumors is challenging and controversial. Here, to characterize intra- and inter-patient cellular heterogeneity, we analyze 54 neuroblastoma tumors spanning broad clinical, genetic, and histologic features using single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq), bulk RNA-sequencing, spatial transcriptomics, and spatial proteomics. We show that tumor cells occupy distinct cellular neighborhoods separated from nonmalignant immune and stromal cells, yet established cell line-derived gene expression signatures fail to identify MES neuroblastoma cells. We therefore develop ADRN/MES signatures from early passage orthotopic patient-derived xenografts, enabling identification of MES tumor cells, validated by transcriptomic, epigenomic, proteomic, ultrastructural and functional assays. In patients, high MES gene expression correlates with worse event-free and overall survival. Together, this study provides a framework for defining clinically relevant neuroblastoma cell states.", "License": "CC-BY-NC-ND-4.0", "PMID": "", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq,Bulk RNA-seq,Bulk DNA,MIBI", "Tool": "Yes", "Supporting Link": "https://viz.stjude.cloud/community/human-tumor-atlas-network-consortium~6", "Supporting Link Description": "Online interactive visualizer to help interrogate the single cell/nucleus atlas, along with individual sample CNA inference heatmaps", "Publication-associated HTAN Parent Data File ID": [ "HTA1_159_17110110111", "HTA1_100_120110111", "HTA1_244_000150101", "HTA1_244_45150101", "HTA1_312_000150101", "HTA1_312_90150101", "HTA1_312_90250101", "HTA1_352_000150101", "HTA1_352_123150101", "HTA1_396_000150101", "HTA1_396_162150101", "HTA1_527_000150101", "HTA1_527_676750101", "HTA1_656_000150101", "HTA1_656_348150101", "HTA1_683_000150101", "HTA1_683_676950101", "HTA1_756_000150101", "HTA1_756_677950101", 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"HTA1_120_41302111", "HTA1_125_71302111121", "HTA1_125_71302111891", "HTA1_130_91302111", "HTA1_130_91306111", "HTA1_136_102302111", "HTA1_136_102306111", "HTA1_141_111302111", "HTA1_141_111306111", "HTA1_148_141302111", "HTA1_148_141306111", "HTA1_204_6601302111", "HTA1_204_6601307111", "HTA1_672_8509302111", "HTA1_672_8509306111" ], "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "HHSN261201500003I", "HTAN Center ID": "HTA1", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.cell.2021.08.003", "Title": "Spatially organized multicellular immune hubs in human colorectal cancer", "Authors": "Karin Pelka, Matan Hofree, Jonathan H Chen, Siranush Sarkizova, Joshua D Pirl, Vjola Jorgji, Alborz Bejnood, Danielle Dionne, William H Ge, Katherine H Xu, Sherry X Chao, Daniel R Zollinger, David J Lieb, Jason W Reeves, Christopher A Fuhrman, Margaret L Hoang, Toni Delorey, Lan T Nguyen, Julia Waldman, Max Klapholz, Isaac Wakiro, Ofir Cohen, Julian Albers, Christopher S Smillie, Michael S Cuoco, Jingyi Wu, Mei-Ju Su, Jason Yeung, Brinda Vijaykumar, Angela M Magnuson, Natasha Asinovski, Tabea Moll, Max N Goder-Reiser, Anise S Applebaum, Lauren K Brais, Laura K DelloStritto, Sarah L Denning, Susannah T Phillips, Emma K Hill, Julia K Meehan, Dennie T Frederick, Tatyana Sharova, Abhay Kanodia, Ellen Z Todres, Judit Jan\u00e9-Valbuena, Moshe Biton, Benjamin Izar, Conner D Lambden, Thomas E Clancy, Ronald Bleday, Nelya Melnitchouk, Jennifer Irani, Hiroko Kunitake, David L Berger, Amitabh Srivastava, Jason L Hornick, Shuji Ogino, Asaf Rotem, S\u00e9bastien Vigneau, Bruce E Johnson, Ryan B Corcoran, Arlene H Sharpe, Vijay K Kuchroo, Kimmie Ng, Marios Giannakis, Linda T Nieman, Genevieve M Boland, Andrew J Aguirre, Ana C Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen", "Corresponding Author": "Nir Hacohen", "Corresponding Author ORCID": "https://orcid.org/0000-0002-2349-2656", "Year of Publication": "2021", "Location of Publication": "Cell", "Publication Abstract": "Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcriptionally profiled 371,223 cells from colorectal tumors and adjacent normal tissues of 28 MMRp and 34 MMRd individuals. Analysis of 88 cell subsets and their 204 associated gene expression programs revealed extensive transcriptional and spatial remodeling across tumors. To discover hubs of interacting malignant and immune cells, we identified expression programs in different cell types that co-varied across tumors from affected individuals and used spatial profiling to localize coordinated programs. We discovered a myeloid cell-attracting hub at the tumor-luminal interface associated with tissue damage and an MMRd-enriched immune hub within the tumor, with activated T cells together with malignant and myeloid cells expressing T cell-attracting chemokines. By identifying interacting cellular programs, we reveal the logic underlying spatially organized immune-malignant cell networks.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/34450029/", "Publication contains HTAN ID": "No", "Data Type": "scRNAseq", "Tool": "Yes", "Supporting Link": "https://github.com/matanhofree/crc-immune-hubs,http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178341,https://portals.broadinstitute.org/crc-immune-hubs", "Supporting Link Description": "Analysis code^^^GEO accession GSE178341 for 10x Single cell RNA-seq data^^^Interactive web pages for exploration of data", "Publication-associated HTAN Parent Data File ID": [ "HTA1_272_48311011", "HTA1_272_48311013", "HTA1_272_48311015", "HTA1_272_48311017", "HTA1_272_48311012", "HTA1_272_48311014", "HTA1_272_48311016", "HTA1_272_48311018", "HTA1_272_4831101101", "HTA1_272_48311011013", "HTA1_272_48311011011", "HTA1_272_48311011012", "HTA1_273_48611011", "HTA1_273_48611012", 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"HTA1_510_57011011011", "HTA1_510_57011011012", "HTA1_556_57611011", "HTA1_556_57611012", "HTA1_556_5761101101", "HTA1_556_57611011013", "HTA1_556_57611011011", "HTA1_556_57611011012", "HTA1_574_58211011", "HTA1_574_58211012", "HTA1_574_5821101101", "HTA1_574_58211011013", "HTA1_574_58211011011", "HTA1_574_58211011012", "HTA1_626_58511011", "HTA1_626_58511012", "HTA1_626_5851101101", "HTA1_626_58511011013", "HTA1_626_58511011011", "HTA1_626_58511011012", "HTA1_650_59411011", "HTA1_650_59411012", "HTA1_650_5941101101", "HTA1_650_59411011013", "HTA1_650_59411011011", "HTA1_650_59411011012", "HTA1_710_60611011", "HTA1_710_60611012", "HTA1_710_6061101101", "HTA1_710_60611011013", "HTA1_710_60611011011", "HTA1_710_60611011012", "HTA1_710_60621011", "HTA1_710_60621012", "HTA1_710_6062101101", "HTA1_710_60621011013", "HTA1_710_60621011011", "HTA1_710_60621011012", "HTA1_272_483110110111" ], "Eutils Date": "2021 Sep 2", "Eutils Title": "Spatially organized multicellular immune hubs in human colorectal cancer.", "Eutils Journal": "Cell", "Eutils Sort Date": "2021/09/02 00:00", "Eutils Authors": "Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, Hoang ML, Delorey T, Nguyen LT, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers J, Smillie CS, Cuoco MS, Wu J, Su MJ, Yeung J, Vijaykumar B, Magnuson AM, Asinovski N, Moll T, Goder-Reiser MN, Applebaum AS, Brais LK, DelloStritto LK, Denning SL, Phillips ST, Hill EK, Meehan JK, Frederick DT, Sharova T, Kanodia A, Todres EZ, Jan\u00e9-Valbuena J, Biton M, Izar B, Lambden CD, Clancy TE, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger DL, Srivastava A, Hornick JL, Ogino S, Rotem A, Vigneau S, Johnson BE, Corcoran RB, Sharpe AH, Kuchroo VK, Ng K, Giannakis M, Nieman LT, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N", "Eutils DOI": "10.1016/j.cell.2021.08.003", "Cited In Number": 495, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=34450029" }, { "Component": "PublicationManifest", "HTAN Grant ID": "HHSN261201500003I", "HTAN Center ID": "HTA1", "Publication Content Type": "Preprint", "DOI": "https://doi.org/10.1101/2023.06.28.546977", "Title": "A cellular and spatial atlas of TP53-associated tissue remodeling in lung adenocarcinoma", "Authors": "William Zhao, Benjamin Kepecs, Navin R. Mahadevan, Asa Segerstolpe, Jason L. Weirather, Naomi R. Besson, Bruno Giotti, Brian Y. Soong, Chendi Li, Sebastien Vigneau, Michal Slyper, Isaac Wakiro, Judit Jane-Valbuena, Orr Ashenberg, Asaf Rotem, Raphael Bueno, Orit Rozenblatt-Rosen, Kathleen Pfaff, Scott Rodig, Aaron N. Hata, Aviv Regev, Bruce E. Johnson, Alexander M. Tsankov", "Corresponding Author": "Alexander M. Tsankov", "Corresponding Author ORCID": "https://orcid.org/0000-0002-7955-4414", "Year of Publication": "2024", "Location of Publication": "biorXiv", "Publication Abstract": "TP53 is the most frequently mutated gene across many cancers and is associated with shorter survival in lung adenocarcinoma (LUAD). To define how TP53 mutations affect the LUAD tumor microenvironment (TME), we constructed a multi-omic cellular and spatial tumor atlas of 23 treatment-na\u00efve human lung tumors. We found that TP53-mutant (TP53mut) malignant cells lose alveolar identity and upregulate highly proliferative and entropic gene expression programs consistently across resectable LUAD patient tumors, genetically engineered mouse models, and cell lines harboring a wide spectrum of TP53 mutations. We further identified a multicellular tumor niche composed of SPP1+ macrophages and collagen-expressing fibroblasts that coincides with hypoxic, pro-metastatic expression programs in TP53mut tumors. Spatially correlated angiostatic and immune checkpoint interactions, including CD274-PDCD1 and PVR-TIGIT, are also enriched in TP53mut LUAD tumors, which may influence response to checkpoint blockade therapy. Our methodology can be further applied to investigate mutation-specific TME changes in other cancers.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/37425718/", "Publication contains HTAN ID": "No", "Data Type": "", "Tool": "No", "Supporting Link": "https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-6149,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE161824", "Supporting Link Description": "Processed scRNA-seq data from an additional 5 studies (both published and unpublished) with available TP53 mutational status were assembled into a validation compendium, consisting of 15 TP53WT and 7 TP53mut tumor samples (ArrayExpress accessions E-MTAB-6149)^^^In-vitro scRNA-seq data from lung cancer A549 cell lines with different induced TP53 variants was obtained from GEO accession GSE161824", "Publication-associated HTAN Parent Data File ID": [ "HTA1_203_000150101", "HTA1_203_3321011", "HTA1_203_332101101", "HTA1_203_3321011013", "HTA1_203_3321012", 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"HTA1_937_796960421", "HTA1_937_796960501", "HTA1_937_796960502", "HTA1_937_796960503", "HTA1_937_796960504", "HTA1_937_796960505", "HTA1_937_796960506", "HTA1_937_796960507", "HTA1_937_796960508", "HTA1_937_796960509", "HTA1_937_796960510", "HTA1_937_796960511", "HTA1_937_796960512", "HTA1_937_796960513", "HTA1_937_796960514", "HTA1_937_796960515", "HTA1_937_796960516", "HTA1_937_796960517", "HTA1_937_796960518", "HTA1_937_796960519", "HTA1_937_796960520", "HTA1_937_796960521", "HTA1_962_000150101", "HTA1_962_47111011", "HTA1_962_4711101101", "HTA1_962_471110110111", "HTA1_962_47111011013", "HTA1_962_47111012", "HTA1_962_47111021", "HTA1_962_4711102101", "HTA1_962_471110210111", "HTA1_962_47111021013", "HTA1_962_47111022", "HTA1_962_471120101" ], "Eutils Date": "2024 Feb 14", "Eutils Title": "A cellular and spatial atlas of TP53 -associated tissue remodeling in lung adenocarcinoma.", "Eutils Journal": "bioRxiv : the preprint server for biology", "Eutils Sort Date": "2024/02/14 00:00", "Eutils Authors": "Zhao W, Kepecs B, Mahadevan NR, Segerstolpe A, Weirather JL, Besson NR, Giotti B, Soong BY, Li C, Vigneau S, Slyper M, Wakiro I, Jane-Valbuena J, Ashenberg O, Rotem A, Bueno R, Rozenblatt-Rosen O, Pfaff K, Rodig S, Hata AN, Regev A, Johnson BE, Tsankov AM", "Eutils DOI": "10.1101/2023.06.28.546977", "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233284", "HTAN Center ID": "HTA8", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.ccell.2021.09.008", "Title": "Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer", "Authors": "Joseph M Chan, \u00c1lvaro Quintanal-Villalonga, Vianne Ran Gao, Yubin Xie, Viola Allaj, Ojasvi Chaudhary, Ignas Masilionis, Jacklynn Egger, Andrew Chow, Thomas Walle, Marissa Mattar, Dig V K Yarlagadda, James L Wang, Fathema Uddin, Michael Offin, Metamia Ciampricotti, Besnik Qeriqi, Amber Bahr, Elisa de Stanchina, Umesh K Bhanot, W Victoria Lai, Matthew J Bott, David R Jones, Arvin Ruiz, Marina K Baine, Yanyun Li, Natasha Rekhtman, John T Poirier, Tal Nawy, Triparna Sen, Linas Mazutis, Travis J Hollmann, Dana Pe'er, Charles M Rudin", "Corresponding Author": "Dana Pe'er,Charles M Rudin", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9259-8817,https://orcid.org/0000-0001-5204-3465", "Year of Publication": "2021", "Location of Publication": "Cancer Cell", "Publication Abstract": "Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A, -N, and -P, respectively). To define the heterogeneity of tumors and their associated microenvironments across subtypes, we sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 SCLC transcriptomes. We observe greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes. We discover a PLCG2-high SCLC phenotype with stem-like, pro-metastatic features that recurs across subtypes and predicts worse overall survival. SCLC exhibits greater immune sequestration and less immune infiltration than lung adenocarcinoma, and SCLC-N shows less immune infiltrate and greater T cell dysfunction than SCLC-A. We identify a profibrotic, immunosuppressive monocyte/macrophage population in SCLC tumors that is particularly associated with the recurrent, PLCG2-high subpopulation.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/34653364/", "Publication contains HTAN ID": "No", "Data Type": "scRNA-seq,MIBI", "Tool": "No", "Supporting Link": "https://github.com/dpeerlab/Vectra_Imaging_pipeline,https://github.com/dpeerlab/MaskRCNN_cell", "Supporting Link Description": "Pipeline for multiplexed imaging quality control and processing^^^Segmentation toolbox based on Mask R-CNN", "Publication-associated HTAN Parent Data File ID": [ "HTA8_1001_110001", "HTA8_1001_110002", "HTA8_1001_110003", "HTA8_1001_110004", "HTA8_1001_210001", "HTA8_1001_310001", "HTA8_1001_310002", "HTA8_1001_310003", "HTA8_1001_310004", "HTA8_4_100073", "HTA8_4_100075", "HTA8_4_100076", "HTA8_4_100078", "HTA8_4_100264", "HTA8_4_100265", "HTA8_4_100051", "HTA8_4_100052", "HTA8_4_100079", "HTA8_4_100080", 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Yarlagadda DVK, Wang JL, Uddin F, Offin M, Ciampricotti M, Qeriqi B, Bahr A, de Stanchina E, Bhanot UK, Lai WV, Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen T, Mazutis L, Hollmann TJ, Pe'er D, Rudin CM", "Eutils DOI": "10.1016/j.ccell.2021.09.008", "Cited In Number": 282, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=34653364" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233284", "HTAN Center ID": "HTA8", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41590-023-01504-2", "Title": "Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies", "Authors": "Ariella Glasner, Samuel A Rose, Roshan Sharma, Herman Gudjonson, Tinyi Chu, Jesse A Green, Sham Rampersaud, Izabella K Valdez, Emma S Andretta, Bahawar S Dhillon, Michail Schizas, Stanislav Dikiy, Alejandra Mendoza, Wei Hu, Zhong-Min Wang, Ojasvi Chaudhary, Tianhao Xu, Linas Mazutis, Gabrielle Rizzuto, Alvaro Quintanal-Villalonga, Parvathy Manoj, Elisa de Stanchina, Charles M Rudin, Dana Pe'er, Alexander Y Rudensky", "Corresponding Author": "Dana Pe'er,Alexander Y Rudensky", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9259-8817,https://orcid.org/0000-0003-1280-2898", "Year of Publication": "2023", "Location of Publication": "Nature Immunology", "Publication Abstract": "While regulatory T (Treg) cells are traditionally viewed as professional suppressors of antigen presenting cells and effector T cells in both autoimmunity and cancer, recent findings of distinct Treg cell functions in tissue maintenance suggest that their regulatory purview extends to a wider range of cells and is broader than previously assumed. To elucidate tumoral Treg cell 'connectivity' to diverse tumor-supporting accessory cell types, we explored immediate early changes in their single-cell transcriptomes upon punctual Treg cell depletion in experimental lung cancer and injury-induced inflammation. Before any notable T cell activation and inflammation, fibroblasts, endothelial and myeloid cells exhibited pronounced changes in their gene expression in both cancer and injury settings. Factor analysis revealed shared Treg cell-dependent gene programs, foremost, prominent upregulation of VEGF and CCR2 signaling-related genes upon Treg cell deprivation in either setting, as well as in Treg cell-poor versus Treg cell-rich human lung adenocarcinomas. Accordingly, punctual Treg cell depletion combined with short-term VEGF blockade showed markedly improved control of PD-1 blockade-resistant lung adenocarcinoma progression in mice compared to the corresponding monotherapies, highlighting a promising factor-based querying approach to elucidating new rational combination treatments of solid organ cancers.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/37127830/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq", "Tool": "Yes", "Supporting Link": "https://github.com/dpeerlab/Treg_depletion_reproducibility/,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE202159", "Supporting Link Description": "All analysis code^^^Raw and processed bulk, scRNA-seq and Visium data from mouse are available from the Gene Expression Omnibus under super series accession GSE202159", "Publication-associated HTAN Parent Data File ID": [ "HTA8_1001_210001", "HTA8_1001_310001", "HTA8_1001_310002", "HTA8_1001_310003", 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"HTA8_1036_210001", "HTA8_1036_310001", "HTA8_1036_110001", "HTA8_1036_110002", "HTA8_1036_110003", "HTA8_1036_110004", "HTA8_1037_210001", "HTA8_1037_310001", "HTA8_1037_110001", "HTA8_1037_110002", "HTA8_1037_110003", "HTA8_1037_110004" ], "UCSC Cell Browser Link": "https://cells.ucsc.edu/?ds=htan-msk", "Eutils Date": "2023 Jun", "Eutils Title": "Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies.", "Eutils Journal": "Nature immunology", "Eutils Sort Date": "2023/06/01 00:00", "Eutils Authors": "Glasner A, Rose SA, Sharma R, Gudjonson H, Chu T, Green JA, Rampersaud S, Valdez IK, Andretta ES, Dhillon BS, Schizas M, Dikiy S, Mendoza A, Hu W, Wang ZM, Chaudhary O, Xu T, Mazutis L, Rizzuto G, Quintanal-Villalonga A, Manoj P, de Stanchina E, Rudin CM, Pe'er D, Rudensky AY", "Eutils DOI": "10.1038/s41590-023-01504-2", "Cited In Number": 36, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=37127830" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233284", "HTAN Center ID": "HTA8", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1158/0008-5472.CAN-25-1117", "Title": "Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer", "Authors": "Jim\u00e9nez-S\u00e1nchez A, Persad S, Hayashi A, Umeda S, Sharma R, Xie Y, Mehta A, Park W, Masilionis I, Chu T, Zhu F, Hong J, Chaligne R, O'Reilly EM, Mazutis L, Nawy T, Pe'er I, Iacobuzio-Donahue CA, Pe'er D", "Corresponding Author": "Dana Pe'er", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9259-8817", "Year of Publication": "2026", "Location of Publication": "Cancer Research", "Publication Abstract": "Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic atlas of primary tumor and diverse metastatic samples from a patient with pancreatic ductal adenocarcinoma who underwent rapid autopsy. Unsupervised archetype analysis identified both shared and site-specific gene programs, including lipid metabolism and gastrointestinal programs prevalent in peritoneum and stomach wall lesions, respectively. We developed a probabilistic approach for inferring clonal phylogeny from single-cell and matched whole-exome data. Distantly related genetic clones in the peritoneum express the lipid metabolism program, likely due to signaling by the adipocyte-rich peritoneum environment, and cells in most clones express multiple programs, suggesting that transcriptomic plasticity is a prevalent feature of metastatic cells. These deeply annotated analyses using a patient-centric platform provide a model for investigating metastatic mechanisms and plasticity in advanced cancer.", "License": "", "PMID": "https://pubmed.ncbi.nlm.nih.gov/41379552/", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "https://ega-archive.org/datasets/EGAD00001011109,https://cellxgene.cziscience.com/gene-expression,https://github.com/dpeerlab/integrateCNV,https://github.com/dpeerlab/picasso,https://github.com/dpeerlab/PLASTRO", "Supporting Link Description": "WES data (BAM files) generated in this study are publicly available through the European Genome-phenome Archive (EGA) as part of the EGAD00001011109 dataset (multiregion sequencing of patients with PDAC)^^^The data analyzed in Fig. 4C and Supplementary Tables S7 and S8 in this study were obtained from the CZ CELLxGENE Discover database^^^IntegrateCNV algorithm, along with documentation, notebooks, and tutorials^^^PICASSO algorithm, as well as documentation and tutorials for inferring CNA phylogenies and visualizing transcriptional and phenotypic information alongside the tree^^^Code for computing the PLASTRO metric, as well as documentation and tutorials", "Publication-associated HTAN Parent Data File ID": [ "HTA8_5001_1", "HTA8_5001_001101", "HTA8_5001_001201", "HTA8_5001_002101", "HTA8_5001_002201", "HTA8_5001_002301", "HTA8_5001_003101", "HTA8_5001_003201", "HTA8_5001_004101", "HTA8_5001_004201", "HTA8_5001_005101", "HTA8_5001_005201", "HTA8_5001_006101", "HTA8_5001_006201", "HTA8_5001_007101", "HTA8_5001_007201", "HTA8_5001_007301", "HTA8_5001_007401", "HTA8_5001_007501", "HTA8_5001_007601", "HTA8_5001_007701", "HTA8_5001_008101", "HTA8_5001_008201", "HTA8_5001_009101", "HTA8_5001_009201", "HTA8_5001_009301", "HTA8_5001_009401", "HTA8_5001_009501", "HTA8_5001_010101", "HTA8_5001_010201", "HTA8_5001_011101", "HTA8_5001_011201", "HTA8_5002_1", "HTA8_5002_001101", "HTA8_5002_001201", "HTA8_5002_002101", "HTA8_5002_003101", "HTA8_5002_003201", "HTA8_5002_004101", "HTA8_5002_005101", "HTA8_5002_005201", "HTA8_5002_006101", "HTA8_5002_006201", "HTA8_5002_007101", "HTA8_5002_007201", "HTA8_5002_007301", "HTA8_5002_008101", "HTA8_5002_008201", "HTA8_5002_009101", "HTA8_5002_009201", "HTA8_5002_010101", "HTA8_5002_010201", "HTA8_5002_011101", "HTA8_5002_011201", "HTA8_5002_012101", "HTA8_5002_012201" ], "Eutils Date": "2026 Apr 2", "Eutils Title": "Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer.", "Eutils Journal": "Cancer research", "Eutils Sort Date": "2026/04/02 00:00", "Eutils Authors": "Jim\u00e9nez-S\u00e1nchez A, Persad S, Hayashi A, Umeda S, Sharma R, Xie Y, Mehta A, Park W, Masilionis I, Chu T, Zhu F, Hong J, Chaligne R, O'Reilly EM, Mazutis L, Nawy T, Pe'er I, Iacobuzio-Donahue CA, Pe'er D", "Eutils DOI": "10.1158/0008-5472.CAN-25-1117", "Cited In Number": 1, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=41379552" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233284", "HTAN Center ID": "HTA8", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41586-024-08150-0", "Title": "Progressive plasticity during colorectal cancer metastasis", "Authors": "A. R. Moorman, E. K. Benitez, F. Cambuli, Q. Jiang, A. Mahmoud, M. Lumish, S. Hartner, S. Balkaran, J. Bermeo, S. Asawa, C. Firat, A. Saxena, F. Wu, A. Luthra, C. Burdziak, Y. Xie, V. Sgambati, K. Luckett, Y. Li, Z. Yi, I. Masilionis, K. Soares, E. Pappou, R. Yaeger, P. Kingham, W. Jarnagin, P. Paty, M. R. Weiser, L. Mazutis, M. D\u2019Angelica, J. Shia, J. Garcia-Aguilar, T. Nawy, T. J. Hollmann, R. Chalign\u00e9, F. Sanchez-Vega, R. Sharma, D. Pe\u2019er, K. Ganesh", "Corresponding Author": "Dana Pe'er,Karuna Ganesh", "Corresponding Author ORCID": "https://orcid.org/0000-0002-9259-8817,https://orcid.org/0000-0002-4948-1082", "Year of Publication": "2024", "Location of Publication": "Nature", "Publication Abstract": "As cancers progress, they become increasingly aggressive-metastatic tumours are less responsive to first-line therapies than primary tumours, they acquire resistance to successive therapies and eventually cause death1,2. Mutations are largely conserved between primary and metastatic tumours from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression and therapy resistance3-5. However, we lack an understanding of metastatic cell states and the mechanisms by which they transition. Here, in a cohort of biospecimen trios from same-patient normal colon, primary and metastatic colorectal cancer, we show that, although primary tumours largely adopt LGR5+ intestinal stem-like states, metastases display progressive plasticity. Cancer cells lose intestinal cell identities and reprogram into a highly conserved fetal progenitor state before undergoing non-canonical differentiation into divergent squamous and neuroendocrine-like states, a process that is exacerbated in metastasis and by chemotherapy and is associated with poor patient survival. Using matched patient-derived organoids, we demonstrate that metastatic cells exhibit greater cell-autonomous multilineage differentiation potential in response to microenvironment cues compared with their intestinal lineage-restricted primary tumour counterparts. We identify PROX1 as a repressor of non-intestinal lineage in the fetal progenitor state, and show that downregulation of PROX1 licenses non-canonical reprogramming.", "License": "", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478232/", "Publication contains HTAN ID": "No", "Data Type": "", "Tool": "No", "Supporting Link": "https://www.gutcellatlas.org/#datasets,https://doi.org/10.7303/syn2623706,https://github.com/dpeerlab/progressive-plasticity-crc-metastasis.git", "Supporting Link Description": "The publicly available Human Space-Time Gut Cell Atlas was used in this study.^^^The publicly available CRC consensus molecular subtypes centroid data were used in this study.^^^Python notebooks with markup and code to replicate figures are available at GitHub.", "Publication-associated HTAN Parent Data File ID": [ "HTA8_6001_001102000", "HTA8_6001_001102001", "HTA8_6001_001102002", "HTA8_6001_001102003", "HTA8_6001_001102004", "HTA8_6001_001102005", "HTA8_6001_001103000", 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colorectal cancer metastasis.", "Eutils Journal": "Nature", "Eutils Sort Date": "2025/01/01 00:00", "Eutils Authors": "Moorman A, Benitez EK, Cambuli F, Jiang Q, Mahmoud A, Lumish M, Hartner S, Balkaran S, Bermeo J, Asawa S, Firat C, Saxena A, Wu F, Luthra A, Burdziak C, Xie Y, Sgambati V, Luckett K, Li Y, Yi Z, Masilionis I, Soares K, Pappou E, Yaeger R, Kingham TP, Jarnagin W, Paty PB, Weiser MR, Mazutis L, D'Angelica M, Shia J, Garcia-Aguilar J, Nawy T, Hollmann TJ, Chalign\u00e9 R, Sanchez-Vega F, Sharma R, Pe'er D, Ganesh K", "Eutils DOI": "10.1038/s41586-024-08150-0", "Cited In Number": 95, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478232" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233280", "HTAN Center ID": "HTA9", "Publication Content Type": "Preprint", "DOI": "https://doi.org/10.1101/2023.09.27.557464", "Title": "Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers", "Authors": "Allison L. Creason, Jay Egger, Cameron Watson, Shamilene Sivagnanam, Koei Chin, Kevin MacPherson, Jia-Ren Lin, Yu-An Chen, Brett E. Johnson, Heidi S. Feiler, Danielle Galipeau, Nicholas E. Navin, Emek Demir, Young Hwan Chang, Christopher L. Corless, Zahi I. Mitri, Peter K. Sorger, George V. Thomas, Lisa M. Coussens, Andrew C. Adey, Joe W. Gray, Gordon B. Mills, Jeremy Goecks", "Corresponding Author": "Jeremy Goecks", "Corresponding Author ORCID": "https://orcid.org/0000-0002-4583-5226", "Year of Publication": "2023", "Location of Publication": "bioRxiv", "Publication Abstract": "CDK4/6 inhibitors (CDK4/6i) have transformed the treatment of hormone receptor-positive (HR+), HER2-negative (HR+) breast cancers as they are effective across all clinicopathological, age, and ethnicity subgroups for metastatic HR+ breast cancer. In metastatic ER+ breast cancer, CDK4/6i lead to strong and consistent improvement in survival across different lines of therapy. To understand how metastatic HR+ breast cancers become refractory to CDK4/6i, we have created a multimodal and longitudinal tumor atlas to investigate therapeutic adaptations in malignant cells and in the tumor immune microenvironment. This atlas is part of the NCI Cancer Moonshot Human Tumor Atlas Network and includes seven pairs of pre- and on-progression biopsies from five metastatic HR+ breast cancer patients treated with CDK4/6i. Biopsies were profiled with bulk genomics, transcriptomics, and proteomics as well as single-cell ATAC-seq and multiplex tissue imaging for spatial, single-cell resolution. These molecular datasets were then linked with detailed clinical metadata to create an atlas for understanding tumor adaptations during therapy. Analysis of our atlas datasets revealed a diverse but tractable set of tumor adaptations to CDK4/6i therapy. Malignant cells adapted to therapy via mTORC1 activation, cell cycle bypass, and increased replication stress. The tumor immune microenvironment displayed evidence of both immune activation and immune suppression, including increased PD-1 expression, features of T cell dysfunction, and CD163+ macrophage infiltration. Together, our metastatic ER+ breast cancer atlas represents a rich multimodal resource to understand tumor therapeutic adaptations to CDK4/6i therapy.", "License": "CC-BY-4.0", "PMID": "", "Publication contains HTAN ID": "No", "Data Type": "Bulk DNA,scATAC-seq,scRNA-seq,CyCIF,mIHC", "Tool": "No", "Supporting Link": "https://github.com/goeckslab/HTAN_HR_Figures", "Supporting Link Description": "Code for creating the figures and panels", "Publication-associated HTAN Parent Data File ID": [ "HTA9_1_1148", "HTA9_1_1146", "HTA9_1_19570", "HTA9_1_1006", "HTA9_1_1101", "HTA9_1_1092", "HTA9_1_1048", "HTA9_1_1026", "HTA9_1_19552", "HTA9_1_1085", "HTA9_1_1024", "HTA9_1_1114", "HTA9_1_1025", "HTA9_1_1100", "HTA9_1_19619", "HTA9_1_19590", "HTA9_1_19579", "HTA9_1_19603", "HTA9_1_19555", "HTA9_1_19554", "HTA9_1_19576", "HTA9_1_19575", "HTA9_1_19607", "HTA9_1_19593", "HTA9_1_19428", "HTA9_1_19487", "HTA9_1_19490", "HTA9_1_19488", "HTA9_1_19440", "HTA9_1_19491", "HTA9_1_19489", "HTA9_1_19492", 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Souraya Mitri, Janice Patterson, Jessica L Riesterer, Shamilene Sivagnanam, Julia Somers, Damir Sudar, Guillaume Thibault, Benjamin R Weeder, Christina Zheng, Xiaolin Nan, Reid F Thompson, Laura M Heiser, Paul T Spellman, George Thomas, Emek Demir, Young Hwan Chang, Lisa M Coussens, Alexander R Guimaraes, Christopher Corless, Jeremy Goecks, Raymond Bergan, Zahi Mitri, Gordon B Mills, Joe W Gray", "Corresponding Author": "Joe W Gray", "Corresponding Author ORCID": "https://orcid.org/0000-0001-9225-6756", "Year of Publication": "2022", "Location of Publication": "Cell Reports Medicine", "Publication Abstract": "Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data report aspects of heterogeneity and evolution of the cancer genome, signaling pathways, immune microenvironment, cellular composition and organization, and ultrastructure. We present illustrative examples of how integrative analyses of these data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/35243422/", "Publication contains HTAN ID": "Yes", "Data Type": "CyCIF,mIHC,Bulk DNA,Bulk RNA-seq", "Tool": "No", "Supporting Link": "https://zenodo.org/records/5608590,https://zenodo.org/records/5637447,https://zenodo.org/records/5608828", "Supporting Link Description": "Transcriptional Regulator Analysis^^^Cyclic Immunofluorescence Analysis code^^^maps2ometiff", "Publication-associated HTAN Parent Data File ID": [ "HTA9_1_1000", "HTA9_1_1001", "HTA9_1_1002", "HTA9_1_1003", "HTA9_1_1004", "HTA9_1_1005", "HTA9_1_1006", "HTA9_1_1007", "HTA9_1_1008", "HTA9_1_1009", "HTA9_1_1010", "HTA9_1_1011", "HTA9_1_1012", "HTA9_1_1013", "HTA9_1_1014", "HTA9_1_10141", "HTA9_1_10144", "HTA9_1_10145", "HTA9_1_10146", "HTA9_1_10147", "HTA9_1_10148", "HTA9_1_10149", 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"HTA9_1_10296", "HTA9_1_10297", "HTA9_1_10298", "HTA9_1_10299", "HTA9_1_1030", "HTA9_1_10300", "HTA9_1_10301", "HTA9_1_10302", "HTA9_1_10303", "HTA9_1_10304", "HTA9_1_10305", "HTA9_1_10306", "HTA9_1_10307", "HTA9_1_10308", "HTA9_1_10309", "HTA9_1_1031", "HTA9_1_10310", "HTA9_1_10311", "HTA9_1_10312", "HTA9_1_10313", "HTA9_1_10314", "HTA9_1_10315", "HTA9_1_10316", "HTA9_1_10317", "HTA9_1_10318", "HTA9_1_10319", "HTA9_1_1032", "HTA9_1_10320", "HTA9_1_10321", "HTA9_1_10322", "HTA9_1_10323", "HTA9_1_10324", "HTA9_1_10325", "HTA9_1_10327", "HTA9_1_10328", "HTA9_1_10329", "HTA9_1_1033", "HTA9_1_10330", "HTA9_1_10331", "HTA9_1_10332", "HTA9_1_10333", "HTA9_1_10334", "HTA9_1_10335", "HTA9_1_10336", "HTA9_1_10337", "HTA9_1_10338", "HTA9_1_10339", "HTA9_1_1034", "HTA9_1_10340", "HTA9_1_10341", "HTA9_1_10342", "HTA9_1_10343", "HTA9_1_10345", "HTA9_1_10346", "HTA9_1_10347", "HTA9_1_10348", "HTA9_1_10349", "HTA9_1_1035", "HTA9_1_10350", "HTA9_1_10351", "HTA9_1_10352", "HTA9_1_10353", "HTA9_1_10357", "HTA9_1_10358", "HTA9_1_10359", "HTA9_1_1036", "HTA9_1_10360", "HTA9_1_10361", "HTA9_1_10364", "HTA9_1_10365", "HTA9_1_10366", "HTA9_1_10368", "HTA9_1_10369", "HTA9_1_1037", "HTA9_1_10370", "HTA9_1_10371", "HTA9_1_10373", "HTA9_1_10374", "HTA9_1_10375", "HTA9_1_10376", "HTA9_1_10377", "HTA9_1_10378", "HTA9_1_10379", "HTA9_1_1038", "HTA9_1_10380", "HTA9_1_10381", "HTA9_1_10382", "HTA9_1_10383", "HTA9_1_10384", "HTA9_1_10385", "HTA9_1_10386", "HTA9_1_10387", "HTA9_1_10389", "HTA9_1_1039", "HTA9_1_10390", "HTA9_1_10391", "HTA9_1_10392", "HTA9_1_10394", "HTA9_1_10395", "HTA9_1_10396", "HTA9_1_10397", "HTA9_1_10398", "HTA9_1_10399", "HTA9_1_1040", "HTA9_1_10400", "HTA9_1_10401", "HTA9_1_10402", "HTA9_1_10403", "HTA9_1_10404", "HTA9_1_10406", "HTA9_1_10407", "HTA9_1_10408", "HTA9_1_10409", "HTA9_1_1041", "HTA9_1_10410", "HTA9_1_10411", "HTA9_1_10412", "HTA9_1_10413", "HTA9_1_10414", "HTA9_1_10415", "HTA9_1_10416", "HTA9_1_10417", "HTA9_1_10418", "HTA9_1_10419", "HTA9_1_1042", "HTA9_1_10420", "HTA9_1_10422", "HTA9_1_10424", "HTA9_1_10425", "HTA9_1_10427", "HTA9_1_10428", "HTA9_1_10429", "HTA9_1_1043", "HTA9_1_10430", "HTA9_1_10431", "HTA9_1_10432", "HTA9_1_10434", "HTA9_1_10435", "HTA9_1_10436", "HTA9_1_10437", "HTA9_1_10438", "HTA9_1_1044", "HTA9_1_10440", "HTA9_1_10442", "HTA9_1_10443", "HTA9_1_10445", "HTA9_1_1045", "HTA9_1_10450", "HTA9_1_10451", "HTA9_1_10452", "HTA9_1_10453", "HTA9_1_10454", "HTA9_1_10455", "HTA9_1_10456", "HTA9_1_10457", "HTA9_1_10458", "HTA9_1_10459", "HTA9_1_1046", "HTA9_1_10460", "HTA9_1_10461", "HTA9_1_10462", "HTA9_1_10463", "HTA9_1_10464", "HTA9_1_10465", "HTA9_1_10466", "HTA9_1_10467", "HTA9_1_10468", "HTA9_1_10469", "HTA9_1_1047", "HTA9_1_10470", "HTA9_1_10471", "HTA9_1_10472", "HTA9_1_10473", "HTA9_1_10474", "HTA9_1_10476", "HTA9_1_10477", "HTA9_1_10478", "HTA9_1_10479", "HTA9_1_1048", "HTA9_1_10480", "HTA9_1_10481", "HTA9_1_10482", "HTA9_1_10483", "HTA9_1_10485", "HTA9_1_10486", "HTA9_1_10487", "HTA9_1_10488", "HTA9_1_1049", "HTA9_1_10490", "HTA9_1_10492", "HTA9_1_10493", "HTA9_1_10494", "HTA9_1_10495", "HTA9_1_10496", "HTA9_1_10497", "HTA9_1_10498", "HTA9_1_10499", "HTA9_1_1050", "HTA9_1_10500", "HTA9_1_10501", "HTA9_1_10503", "HTA9_1_10505", "HTA9_1_10506", "HTA9_1_10507", "HTA9_1_10508", "HTA9_1_1051", "HTA9_1_10510", "HTA9_1_10511", "HTA9_1_10512", "HTA9_1_10515", "HTA9_1_10516", "HTA9_1_10518", "HTA9_1_10519", "HTA9_1_1052", "HTA9_1_10520", "HTA9_1_10521", "HTA9_1_10523", "HTA9_1_10524", "HTA9_1_10525", "HTA9_1_10526", "HTA9_1_10527", "HTA9_1_10529", "HTA9_1_1053", "HTA9_1_10530", "HTA9_1_10531", "HTA9_1_10532", "HTA9_1_10533", "HTA9_1_10534", "HTA9_1_10535", "HTA9_1_10536", "HTA9_1_10537", "HTA9_1_10539", "HTA9_1_1054", "HTA9_1_10540", "HTA9_1_10541", "HTA9_1_10542", "HTA9_1_10543", "HTA9_1_10544", "HTA9_1_10545", "HTA9_1_10546", "HTA9_1_10548", "HTA9_1_10549", "HTA9_1_1055", "HTA9_1_10550", "HTA9_1_10552", "HTA9_1_10553", "HTA9_1_10555", "HTA9_1_10556", "HTA9_1_10557", "HTA9_1_10558", "HTA9_1_1056", "HTA9_1_10560", "HTA9_1_10562", "HTA9_1_10563", "HTA9_1_10564", "HTA9_1_10565", "HTA9_1_10566", "HTA9_1_10567", "HTA9_1_10569", "HTA9_1_1057", "HTA9_1_10570", "HTA9_1_10571", "HTA9_1_10575", "HTA9_1_10576", "HTA9_1_10577", "HTA9_1_10578", "HTA9_1_10579", "HTA9_1_1058", "HTA9_1_10580", "HTA9_1_10581", "HTA9_1_10583", "HTA9_1_10584", "HTA9_1_10585", "HTA9_1_10586", "HTA9_1_10587", "HTA9_1_10588", "HTA9_1_1059", "HTA9_1_10590", "HTA9_1_10591", "HTA9_1_10592", "HTA9_1_10593", "HTA9_1_10594", "HTA9_1_10595", "HTA9_1_10596", "HTA9_1_10597", "HTA9_1_10598", "HTA9_1_10599", "HTA9_1_1060", "HTA9_1_10600", "HTA9_1_10601", "HTA9_1_10603", "HTA9_1_10605", "HTA9_1_10606", "HTA9_1_10607", "HTA9_1_10608", "HTA9_1_10609", "HTA9_1_1061", "HTA9_1_10611", "HTA9_1_10612", "HTA9_1_10613", "HTA9_1_10615", "HTA9_1_10616", "HTA9_1_10618", "HTA9_1_10619", "HTA9_1_1062", "HTA9_1_10621", "HTA9_1_10623", "HTA9_1_10624", "HTA9_1_10626", "HTA9_1_10628", "HTA9_1_10629", "HTA9_1_1063", "HTA9_1_10630", "HTA9_1_10631", "HTA9_1_10632", "HTA9_1_10633", "HTA9_1_10636", "HTA9_1_10637", "HTA9_1_10638", "HTA9_1_1064", "HTA9_1_10640", "HTA9_1_10641", "HTA9_1_10642", "HTA9_1_10643", "HTA9_1_10644", "HTA9_1_10645", "HTA9_1_10646", "HTA9_1_10647", "HTA9_1_10648", "HTA9_1_1065", "HTA9_1_10650", "HTA9_1_10651", "HTA9_1_10652", "HTA9_1_10653", "HTA9_1_10654", "HTA9_1_10655", "HTA9_1_10656", "HTA9_1_10657", "HTA9_1_10658", "HTA9_1_10659", "HTA9_1_1066", "HTA9_1_10660", "HTA9_1_10663", "HTA9_1_10664", "HTA9_1_10665", "HTA9_1_10666", "HTA9_1_10667", "HTA9_1_1067", "HTA9_1_10670", "HTA9_1_10672", "HTA9_1_10673", "HTA9_1_10674", "HTA9_1_10675", "HTA9_1_10678", "HTA9_1_10679", "HTA9_1_1068", "HTA9_1_10680", "HTA9_1_10681", "HTA9_1_10682", "HTA9_1_10683", "HTA9_1_10684", "HTA9_1_10685", "HTA9_1_10686", "HTA9_1_10687", "HTA9_1_10688", "HTA9_1_10689", "HTA9_1_1069", "HTA9_1_10691", "HTA9_1_10692", "HTA9_1_10694", "HTA9_1_10696", "HTA9_1_10697", "HTA9_1_10698", "HTA9_1_10699", "HTA9_1_1070", "HTA9_1_10700", "HTA9_1_10701", "HTA9_1_10702", "HTA9_1_10703", "HTA9_1_10704", "HTA9_1_10705", "HTA9_1_10706", "HTA9_1_10707", "HTA9_1_10708", "HTA9_1_10709", "HTA9_1_1071", "HTA9_1_10710", "HTA9_1_10711", "HTA9_1_10712", "HTA9_1_10713", "HTA9_1_10716", "HTA9_1_10718", "HTA9_1_10719", "HTA9_1_1072", "HTA9_1_10720", "HTA9_1_10721", "HTA9_1_10722", "HTA9_1_10723", "HTA9_1_10724", "HTA9_1_10725", "HTA9_1_10726", "HTA9_1_10728", "HTA9_1_10729", "HTA9_1_1073", "HTA9_1_10730", "HTA9_1_10731", "HTA9_1_10735", "HTA9_1_10736", "HTA9_1_10737", "HTA9_1_10738", "HTA9_1_1074", "HTA9_1_10740", "HTA9_1_10741", "HTA9_1_10742", "HTA9_1_10743", "HTA9_1_10744", "HTA9_1_10745", "HTA9_1_10746", "HTA9_1_10747", "HTA9_1_10749", "HTA9_1_1075", "HTA9_1_10751", "HTA9_1_10752", "HTA9_1_10754", "HTA9_1_10755", "HTA9_1_10756", "HTA9_1_10757", "HTA9_1_10758", "HTA9_1_10759", "HTA9_1_1076", "HTA9_1_10762", "HTA9_1_10764", "HTA9_1_10765", "HTA9_1_10766", "HTA9_1_10767", "HTA9_1_10769", "HTA9_1_1077", "HTA9_1_10770", "HTA9_1_10771", "HTA9_1_10772", "HTA9_1_10773", "HTA9_1_10774", "HTA9_1_10775", "HTA9_1_10776", "HTA9_1_10777", "HTA9_1_10778", "HTA9_1_10779", "HTA9_1_1078", "HTA9_1_10780", "HTA9_1_10782", "HTA9_1_10784", "HTA9_1_10785", "HTA9_1_10786", "HTA9_1_10787", "HTA9_1_10788", "HTA9_1_10789", "HTA9_1_1079", "HTA9_1_10790", "HTA9_1_10791", "HTA9_1_10792", "HTA9_1_10793", "HTA9_1_10794", "HTA9_1_10795", "HTA9_1_10796", "HTA9_1_10797", "HTA9_1_10798", "HTA9_1_10799", "HTA9_1_1080", "HTA9_1_10800", "HTA9_1_10801", "HTA9_1_10802", "HTA9_1_10803", "HTA9_1_10804", "HTA9_1_10807", "HTA9_1_10809", "HTA9_1_1081", "HTA9_1_10810", "HTA9_1_10811", "HTA9_1_10813", "HTA9_1_10814", "HTA9_1_10815", "HTA9_1_10816", "HTA9_1_10818", "HTA9_1_10819", "HTA9_1_1082", "HTA9_1_10820", "HTA9_1_10822", "HTA9_1_10823", "HTA9_1_10825", "HTA9_1_10827", "HTA9_1_10828", "HTA9_1_10829", "HTA9_1_1083", "HTA9_1_10830", "HTA9_1_10831", "HTA9_1_10832", "HTA9_1_10835", "HTA9_1_10836", "HTA9_1_10837", "HTA9_1_10838", "HTA9_1_10839", "HTA9_1_1084", "HTA9_1_10840", "HTA9_1_10841", "HTA9_1_10842", "HTA9_1_10843", "HTA9_1_10845", "HTA9_1_10846", "HTA9_1_10847", "HTA9_1_10848", "HTA9_1_10849", "HTA9_1_1085", "HTA9_1_10850", "HTA9_1_10851", "HTA9_1_10852", "HTA9_1_10853", "HTA9_1_10854", "HTA9_1_10855", "HTA9_1_10856", "HTA9_1_10858", "HTA9_1_10859", "HTA9_1_1086", "HTA9_1_10860", "HTA9_1_10861", "HTA9_1_10863", "HTA9_1_10864", "HTA9_1_10865", "HTA9_1_10866", "HTA9_1_10869", "HTA9_1_1087", "HTA9_1_10870", "HTA9_1_10871", "HTA9_1_10872", "HTA9_1_10873", "HTA9_1_10874", "HTA9_1_10875", "HTA9_1_10876", "HTA9_1_10877", "HTA9_1_10878", "HTA9_1_10879", "HTA9_1_1088", "HTA9_1_10880", "HTA9_1_10881", "HTA9_1_10882", "HTA9_1_10883", "HTA9_1_10885", "HTA9_1_10886", "HTA9_1_10887", "HTA9_1_10888", "HTA9_1_10889", "HTA9_1_1089", "HTA9_1_10890", "HTA9_1_10891", "HTA9_1_10892", "HTA9_1_10893", "HTA9_1_10894", "HTA9_1_10895", "HTA9_1_10896", "HTA9_1_10897", "HTA9_1_10898", "HTA9_1_10899", "HTA9_1_1090", "HTA9_1_10900", "HTA9_1_10901", "HTA9_1_10902", "HTA9_1_10904", "HTA9_1_10905", "HTA9_1_10906", "HTA9_1_10907", "HTA9_1_10908", "HTA9_1_10909", "HTA9_1_1091", "HTA9_1_10910", "HTA9_1_10911", "HTA9_1_10912", "HTA9_1_10913", "HTA9_1_10915", "HTA9_1_10916", "HTA9_1_10917", "HTA9_1_10918", "HTA9_1_10919", "HTA9_1_1092", "HTA9_1_10920", "HTA9_1_10921", "HTA9_1_10922", "HTA9_1_10923", "HTA9_1_10924", "HTA9_1_10925", "HTA9_1_10926", "HTA9_1_10927", "HTA9_1_10928", "HTA9_1_10929", "HTA9_1_1093", "HTA9_1_10930", "HTA9_1_10931", "HTA9_1_10932", "HTA9_1_10933", "HTA9_1_10934", "HTA9_1_10935", "HTA9_1_10936", "HTA9_1_10937", "HTA9_1_10939", "HTA9_1_1094", "HTA9_1_10941", "HTA9_1_10942", "HTA9_1_10945", "HTA9_1_10946", "HTA9_1_10947", "HTA9_1_10948", "HTA9_1_1095", "HTA9_1_10951", "HTA9_1_10952", "HTA9_1_10954", "HTA9_1_10955", "HTA9_1_10956", "HTA9_1_10957", "HTA9_1_10958", "HTA9_1_10959", "HTA9_1_1096", "HTA9_1_10960", "HTA9_1_10963", "HTA9_1_10964", "HTA9_1_10965", "HTA9_1_10967", "HTA9_1_10968", "HTA9_1_10969", "HTA9_1_1097", "HTA9_1_10970", "HTA9_1_10971", "HTA9_1_10972", "HTA9_1_10973", "HTA9_1_10974", "HTA9_1_10975", "HTA9_1_10976", "HTA9_1_10977", "HTA9_1_10978", "HTA9_1_10979", "HTA9_1_1098", "HTA9_1_10980", "HTA9_1_10981", "HTA9_1_10982", "HTA9_1_10983", "HTA9_1_10984", "HTA9_1_10985", "HTA9_1_10986", "HTA9_1_10987", "HTA9_1_10988", "HTA9_1_1099", "HTA9_1_10990", "HTA9_1_10991", "HTA9_1_10992", "HTA9_1_10994", "HTA9_1_10995", "HTA9_1_10996", "HTA9_1_10997", "HTA9_1_10998", "HTA9_1_10999", "HTA9_1_1100", "HTA9_1_11000", "HTA9_1_11001", "HTA9_1_11002", "HTA9_1_11003", "HTA9_1_11004", "HTA9_1_11005", "HTA9_1_11006", "HTA9_1_11007", "HTA9_1_11008", "HTA9_1_1101", "HTA9_1_11010", "HTA9_1_11011", "HTA9_1_11012", "HTA9_1_11013", "HTA9_1_11014", "HTA9_1_11015", "HTA9_1_11016", "HTA9_1_11017", "HTA9_1_11018", "HTA9_1_11019", "HTA9_1_1102", "HTA9_1_11020", "HTA9_1_11021", "HTA9_1_11022", "HTA9_1_11023", "HTA9_1_11024", "HTA9_1_11025", "HTA9_1_11026", "HTA9_1_11027", "HTA9_1_1103", "HTA9_1_11030", "HTA9_1_11031", "HTA9_1_11032", "HTA9_1_11033", "HTA9_1_11036", "HTA9_1_11037", "HTA9_1_11038", "HTA9_1_11039", "HTA9_1_1104", "HTA9_1_11040", "HTA9_1_11041", "HTA9_1_11042", "HTA9_1_11044", "HTA9_1_11045", "HTA9_1_11047", "HTA9_1_1105", "HTA9_1_11050", "HTA9_1_11051", "HTA9_1_11052", "HTA9_1_11055", "HTA9_1_11056", "HTA9_1_11057", "HTA9_1_11058", "HTA9_1_11059", "HTA9_1_1106", "HTA9_1_11060", "HTA9_1_11061", "HTA9_1_11062", "HTA9_1_11063", "HTA9_1_11064", "HTA9_1_11065", "HTA9_1_11066", "HTA9_1_11068", "HTA9_1_11069", "HTA9_1_1107", "HTA9_1_11070", "HTA9_1_11071", "HTA9_1_11072", "HTA9_1_11073", "HTA9_1_11074", "HTA9_1_11075", "HTA9_1_11076", "HTA9_1_11078", "HTA9_1_11079", "HTA9_1_1108", "HTA9_1_11080", "HTA9_1_11081", "HTA9_1_11083", "HTA9_1_11084", "HTA9_1_11085", "HTA9_1_11086", "HTA9_1_11087", "HTA9_1_11088", "HTA9_1_1109", "HTA9_1_11090", "HTA9_1_11092", "HTA9_1_11093", "HTA9_1_11094", "HTA9_1_11095", "HTA9_1_11096", "HTA9_1_11097", "HTA9_1_11099", "HTA9_1_1110", "HTA9_1_11100", "HTA9_1_11101", "HTA9_1_11103", "HTA9_1_11105", "HTA9_1_11106", "HTA9_1_11108", "HTA9_1_11109", "HTA9_1_1111", "HTA9_1_11110", "HTA9_1_11111", "HTA9_1_11112", "HTA9_1_11114", "HTA9_1_11115", "HTA9_1_11116", "HTA9_1_11117", "HTA9_1_11118", "HTA9_1_11119", "HTA9_1_1112", "HTA9_1_11120", "HTA9_1_11121", "HTA9_1_11122", "HTA9_1_11123", "HTA9_1_11124", "HTA9_1_11126", "HTA9_1_11127", "HTA9_1_11128", "HTA9_1_1113", "HTA9_1_11133", "HTA9_1_11134", "HTA9_1_11135", "HTA9_1_11136", "HTA9_1_11137", "HTA9_1_11138", "HTA9_1_11139", "HTA9_1_1114", "HTA9_1_11140", "HTA9_1_11141", "HTA9_1_11142", "HTA9_1_11144", "HTA9_1_11145", "HTA9_1_11146", "HTA9_1_11147", "HTA9_1_11148", "HTA9_1_11149", "HTA9_1_1115", "HTA9_1_11150", "HTA9_1_11152", "HTA9_1_11153", "HTA9_1_11154", "HTA9_1_11155", "HTA9_1_11156", "HTA9_1_11157", "HTA9_1_11158", "HTA9_1_11159", "HTA9_1_1116", "HTA9_1_11160", "HTA9_1_11162", "HTA9_1_11163", "HTA9_1_11164", "HTA9_1_11165", "HTA9_1_11166", "HTA9_1_11167", "HTA9_1_11168", "HTA9_1_1117", "HTA9_1_11170", "HTA9_1_11171", "HTA9_1_11172", "HTA9_1_11173", "HTA9_1_11175", "HTA9_1_11176", "HTA9_1_11177", "HTA9_1_11178", "HTA9_1_11179", "HTA9_1_1118", "HTA9_1_11180", "HTA9_1_11181", "HTA9_1_11182", "HTA9_1_11185", "HTA9_1_11186", "HTA9_1_11187", "HTA9_1_11188", "HTA9_1_11189", "HTA9_1_1119", "HTA9_1_11190", "HTA9_1_11191", "HTA9_1_11192", "HTA9_1_11193", "HTA9_1_11194", "HTA9_1_11195", "HTA9_1_11196", "HTA9_1_11197", "HTA9_1_11198", "HTA9_1_11199", "HTA9_1_1120", "HTA9_1_11200", "HTA9_1_11201", "HTA9_1_11202", "HTA9_1_11204", "HTA9_1_11205", "HTA9_1_11206", "HTA9_1_11207", "HTA9_1_11209", "HTA9_1_1121", "HTA9_1_11210", "HTA9_1_11211", "HTA9_1_11212", "HTA9_1_11213", "HTA9_1_11215", "HTA9_1_11216", "HTA9_1_11217", "HTA9_1_11218", "HTA9_1_11219", "HTA9_1_1122", "HTA9_1_11221", "HTA9_1_11222", "HTA9_1_11223", "HTA9_1_11224", "HTA9_1_11225", "HTA9_1_11228", "HTA9_1_11229", "HTA9_1_1123", "HTA9_1_11230", "HTA9_1_11232", "HTA9_1_11233", "HTA9_1_11234", "HTA9_1_11235", "HTA9_1_11236", "HTA9_1_11237", "HTA9_1_11238", "HTA9_1_1124", "HTA9_1_11240", "HTA9_1_11241", "HTA9_1_11242", "HTA9_1_11243", "HTA9_1_11244", "HTA9_1_11246", "HTA9_1_11247", "HTA9_1_1125", "HTA9_1_11250", "HTA9_1_11251", "HTA9_1_11252", "HTA9_1_11253", "HTA9_1_11254", "HTA9_1_11255", "HTA9_1_11256", "HTA9_1_11258", "HTA9_1_11259", "HTA9_1_1126", "HTA9_1_11261", "HTA9_1_11262", "HTA9_1_11263", "HTA9_1_11264", "HTA9_1_11265", "HTA9_1_11266", "HTA9_1_11267", "HTA9_1_11268", "HTA9_1_11269", "HTA9_1_1127", "HTA9_1_11270", "HTA9_1_11271", "HTA9_1_11272", "HTA9_1_11273", "HTA9_1_11274", "HTA9_1_11275", "HTA9_1_11276", "HTA9_1_11277", "HTA9_1_11278", "HTA9_1_11279", "HTA9_1_1128", "HTA9_1_11281", "HTA9_1_11282", "HTA9_1_11283", "HTA9_1_11284", "HTA9_1_11285", "HTA9_1_11286", "HTA9_1_11287", "HTA9_1_11288", "HTA9_1_11289", "HTA9_1_1129", "HTA9_1_11290", "HTA9_1_11291", "HTA9_1_11292", "HTA9_1_11294", "HTA9_1_11295", "HTA9_1_11296", "HTA9_1_11297", "HTA9_1_11299", "HTA9_1_1130", "HTA9_1_11300", "HTA9_1_11302", "HTA9_1_11303", "HTA9_1_11306", "HTA9_1_11308", "HTA9_1_11309", "HTA9_1_1131", "HTA9_1_11310", "HTA9_1_11311", "HTA9_1_11312", "HTA9_1_11314", "HTA9_1_11316", "HTA9_1_11317", "HTA9_1_11318", "HTA9_1_1132", "HTA9_1_11320", "HTA9_1_11321", "HTA9_1_11322", "HTA9_1_11323", "HTA9_1_11324", "HTA9_1_11326", "HTA9_1_11327", "HTA9_1_11328", "HTA9_1_11329", "HTA9_1_1133", "HTA9_1_11332", "HTA9_1_11333", "HTA9_1_11334", "HTA9_1_11335", "HTA9_1_11336", "HTA9_1_11337", "HTA9_1_11338", "HTA9_1_11339", "HTA9_1_1134", "HTA9_1_11341", "HTA9_1_11342", "HTA9_1_11343", "HTA9_1_11344", "HTA9_1_11346", "HTA9_1_11347", "HTA9_1_11348", "HTA9_1_11349", "HTA9_1_1135", "HTA9_1_11350", "HTA9_1_11351", "HTA9_1_11352", "HTA9_1_11354", "HTA9_1_11355", "HTA9_1_11356", "HTA9_1_11357", "HTA9_1_11358", "HTA9_1_11359", "HTA9_1_1136", "HTA9_1_11360", "HTA9_1_11361", "HTA9_1_11362", "HTA9_1_11363", "HTA9_1_11364", "HTA9_1_11365", "HTA9_1_11366", "HTA9_1_11367", "HTA9_1_11368", "HTA9_1_11369", "HTA9_1_1137", "HTA9_1_11372", "HTA9_1_11374", "HTA9_1_11375", "HTA9_1_11378", "HTA9_1_11379", "HTA9_1_1138", "HTA9_1_11380", "HTA9_1_11381", "HTA9_1_11382", "HTA9_1_11383", "HTA9_1_11384", "HTA9_1_11385", "HTA9_1_11386", "HTA9_1_11387", "HTA9_1_11388", "HTA9_1_1139", "HTA9_1_11390", "HTA9_1_11391", "HTA9_1_11392", "HTA9_1_11394", "HTA9_1_11395", "HTA9_1_11396", "HTA9_1_11397", "HTA9_1_11399", "HTA9_1_1140", "HTA9_1_11400", "HTA9_1_11401", "HTA9_1_11402", "HTA9_1_11403", "HTA9_1_11404", "HTA9_1_11405", "HTA9_1_11406", "HTA9_1_11407", "HTA9_1_11408", "HTA9_1_11409", "HTA9_1_1141", "HTA9_1_11410", "HTA9_1_11411", "HTA9_1_11412", "HTA9_1_11413", "HTA9_1_11416", "HTA9_1_11417", "HTA9_1_11418", "HTA9_1_11419", "HTA9_1_1142", "HTA9_1_11421", "HTA9_1_11422", "HTA9_1_11423", "HTA9_1_11424", "HTA9_1_11425", "HTA9_1_11426", "HTA9_1_11427", "HTA9_1_11428", "HTA9_1_11429", "HTA9_1_1143", "HTA9_1_11430", "HTA9_1_11431", "HTA9_1_11432", "HTA9_1_11435", "HTA9_1_11437", "HTA9_1_11439", "HTA9_1_1144", "HTA9_1_11440", "HTA9_1_11443", "HTA9_1_11444", "HTA9_1_11445", "HTA9_1_11446", "HTA9_1_11447", "HTA9_1_11449", "HTA9_1_1145", "HTA9_1_11450", "HTA9_1_11452", "HTA9_1_11453", "HTA9_1_11454", "HTA9_1_11455", "HTA9_1_11456", "HTA9_1_11457", "HTA9_1_11459", "HTA9_1_1146", "HTA9_1_11460", "HTA9_1_11461", "HTA9_1_11462", "HTA9_1_11463", "HTA9_1_11464", "HTA9_1_11466", "HTA9_1_11467", "HTA9_1_11469", "HTA9_1_1147", "HTA9_1_11470", "HTA9_1_11472", "HTA9_1_11474", "HTA9_1_11475", "HTA9_1_11476", "HTA9_1_11479", "HTA9_1_1148", "HTA9_1_11480", "HTA9_1_11481", "HTA9_1_11482", "HTA9_1_11483", "HTA9_1_11485", "HTA9_1_11486", "HTA9_1_11487", "HTA9_1_11489", "HTA9_1_1149", "HTA9_1_11490", "HTA9_1_11492", "HTA9_1_11493", "HTA9_1_11494", "HTA9_1_11495", "HTA9_1_11496", "HTA9_1_11499", "HTA9_1_1150", "HTA9_1_11500", "HTA9_1_11501", "HTA9_1_11502", "HTA9_1_11503", "HTA9_1_11504", "HTA9_1_11506", "HTA9_1_11507", "HTA9_1_11508", "HTA9_1_11509", "HTA9_1_1151", "HTA9_1_11511", "HTA9_1_11512", "HTA9_1_11513", "HTA9_1_11515", "HTA9_1_11516", "HTA9_1_11517", "HTA9_1_11518", "HTA9_1_11519", "HTA9_1_11520", "HTA9_1_11521", "HTA9_1_11523", "HTA9_1_11524", "HTA9_1_11525", "HTA9_1_11526", "HTA9_1_11527", "HTA9_1_11528", "HTA9_1_11529", "HTA9_1_11530", "HTA9_1_11531", "HTA9_1_11532", "HTA9_1_11533", "HTA9_1_11534", "HTA9_1_11535", "HTA9_1_11536", "HTA9_1_11537", "HTA9_1_11538", "HTA9_1_11539", "HTA9_1_11540", "HTA9_1_11541", "HTA9_1_11542", "HTA9_1_11543", "HTA9_1_11544", "HTA9_1_11545", "HTA9_1_11546", "HTA9_1_11547", "HTA9_1_11548", "HTA9_1_11549", "HTA9_1_11550", "HTA9_1_11551", "HTA9_1_11552", "HTA9_1_11554", "HTA9_1_11555", "HTA9_1_11556", "HTA9_1_11557", "HTA9_1_11558", "HTA9_1_11559", "HTA9_1_11560", "HTA9_1_11561", "HTA9_1_11562", "HTA9_1_11563", "HTA9_1_11564", "HTA9_1_11565", "HTA9_1_11566", "HTA9_1_11567", "HTA9_1_11568", "HTA9_1_11569", "HTA9_1_11570", "HTA9_1_11571", "HTA9_1_11573", "HTA9_1_11574", "HTA9_1_11575", "HTA9_1_11576", "HTA9_1_11578", "HTA9_1_11579", "HTA9_1_1158", "HTA9_1_11581", "HTA9_1_11582", "HTA9_1_11583", "HTA9_1_11584", "HTA9_1_11585", "HTA9_1_11586", "HTA9_1_11587", "HTA9_1_11588", "HTA9_1_11589", "HTA9_1_1159", "HTA9_1_11590", "HTA9_1_11591", "HTA9_1_11592", "HTA9_1_11593", "HTA9_1_11594", "HTA9_1_11595", "HTA9_1_11596", "HTA9_1_11598", "HTA9_1_11599", "HTA9_1_1160", "HTA9_1_11600", "HTA9_1_11601", "HTA9_1_11602", "HTA9_1_11603", "HTA9_1_11605", "HTA9_1_11606", "HTA9_1_11609", "HTA9_1_1161", "HTA9_1_11610", "HTA9_1_11611", "HTA9_1_11613", "HTA9_1_11615", "HTA9_1_11616", "HTA9_1_11617", "HTA9_1_11618", "HTA9_1_11619", "HTA9_1_1162", "HTA9_1_11620", "HTA9_1_11622", "HTA9_1_11623", "HTA9_1_11624", "HTA9_1_11626", "HTA9_1_11627", "HTA9_1_11628", "HTA9_1_11629", "HTA9_1_1163", "HTA9_1_11631", "HTA9_1_11632", "HTA9_1_11633", "HTA9_1_11634", "HTA9_1_11635", "HTA9_1_11636", "HTA9_1_11637", "HTA9_1_11638", "HTA9_1_11639", "HTA9_1_11640", "HTA9_1_11641", "HTA9_1_11642", "HTA9_1_11643", "HTA9_1_11644", "HTA9_1_11645", "HTA9_1_11646", "HTA9_1_11647", "HTA9_1_11648", "HTA9_1_11649", "HTA9_1_11651", "HTA9_1_11652", "HTA9_1_11654", "HTA9_1_11655", "HTA9_1_11659", "HTA9_1_11660", "HTA9_1_11661", "HTA9_1_11662", "HTA9_1_11664", "HTA9_1_11667", "HTA9_1_11668", "HTA9_1_11669", "HTA9_1_11670", "HTA9_1_11671", "HTA9_1_11673", "HTA9_1_11674", "HTA9_1_11675", "HTA9_1_11676", "HTA9_1_11677", "HTA9_1_11678", "HTA9_1_11681", "HTA9_1_11682", "HTA9_1_11683", "HTA9_1_11685", "HTA9_1_11686", "HTA9_1_11687", "HTA9_1_11688", "HTA9_1_11689", "HTA9_1_11692", "HTA9_1_11693", "HTA9_1_11694", "HTA9_1_11695", "HTA9_1_11696", "HTA9_1_11699", "HTA9_1_11700", "HTA9_1_11701", "HTA9_1_11702", "HTA9_1_11703", "HTA9_1_11704", "HTA9_1_11705", "HTA9_1_11706", "HTA9_1_11707", "HTA9_1_11709", "HTA9_1_11710", "HTA9_1_11711", "HTA9_1_11712", "HTA9_1_11714", "HTA9_1_11717", "HTA9_1_11719", "HTA9_1_11720", "HTA9_1_11721", "HTA9_1_11722", "HTA9_1_11723", "HTA9_1_11724", "HTA9_1_11725", "HTA9_1_11726", "HTA9_1_11727", "HTA9_1_11728", "HTA9_1_11730", "HTA9_1_11732", "HTA9_1_11733", "HTA9_1_11734", "HTA9_1_11735", "HTA9_1_11736", "HTA9_1_11737", "HTA9_1_11740", "HTA9_1_11741", "HTA9_1_11742", "HTA9_1_11743", "HTA9_1_11744", "HTA9_1_11745", "HTA9_1_11746", "HTA9_1_11748", "HTA9_1_11749", "HTA9_1_11751", "HTA9_1_11752", "HTA9_1_11753", "HTA9_1_11756", "HTA9_1_11757", "HTA9_1_11758", "HTA9_1_11759", "HTA9_1_11760", "HTA9_1_11762", "HTA9_1_11763", "HTA9_1_11764", "HTA9_1_11765", "HTA9_1_11766", "HTA9_1_11767", "HTA9_1_11768", "HTA9_1_11769", "HTA9_1_11770", "HTA9_1_11771", "HTA9_1_11772", "HTA9_1_11773", "HTA9_1_11774", "HTA9_1_11775", "HTA9_1_11776", "HTA9_1_11778", "HTA9_1_11779", "HTA9_1_11780", "HTA9_1_11781", "HTA9_1_11782", "HTA9_1_11783", "HTA9_1_11784", "HTA9_1_11785", "HTA9_1_11786", "HTA9_1_11787", "HTA9_1_11788", "HTA9_1_11789", "HTA9_1_11790", "HTA9_1_11791", "HTA9_1_11793", "HTA9_1_11794", "HTA9_1_11795", "HTA9_1_11797", "HTA9_1_11798", "HTA9_1_11799", "HTA9_1_11800", "HTA9_1_11801", "HTA9_1_11802", "HTA9_1_11803", "HTA9_1_11804", "HTA9_1_11805", "HTA9_1_11806", "HTA9_1_11807", "HTA9_1_11810", "HTA9_1_11813", "HTA9_1_11814", "HTA9_1_11815", "HTA9_1_11817", "HTA9_1_11819", "HTA9_1_11821", "HTA9_1_11823", "HTA9_1_11824", "HTA9_1_11825", "HTA9_1_11827", "HTA9_1_11828", "HTA9_1_11829", "HTA9_1_11830", "HTA9_1_11831", "HTA9_1_11832", "HTA9_1_11833", "HTA9_1_11834", "HTA9_1_11835", "HTA9_1_11836", "HTA9_1_11837", "HTA9_1_11838", "HTA9_1_11840", "HTA9_1_11841", "HTA9_1_11842", "HTA9_1_11843", "HTA9_1_11844", "HTA9_1_11845", "HTA9_1_11846", "HTA9_1_11847", "HTA9_1_11848", "HTA9_1_11849", "HTA9_1_11850", "HTA9_1_11851", "HTA9_1_11852", "HTA9_1_11854", "HTA9_1_11855", "HTA9_1_11857", "HTA9_1_11858", "HTA9_1_11859", "HTA9_1_11860", "HTA9_1_11861", "HTA9_1_11862", "HTA9_1_11863", "HTA9_1_11864", "HTA9_1_11868", "HTA9_1_11869", "HTA9_1_11870", "HTA9_1_11871", "HTA9_1_11872", "HTA9_1_11873", "HTA9_1_11874", "HTA9_1_11875", "HTA9_1_11876", "HTA9_1_11877", "HTA9_1_11878", "HTA9_1_11879", "HTA9_1_11880", "HTA9_1_11883", "HTA9_1_11884", "HTA9_1_11885", "HTA9_1_11886", "HTA9_1_11887", "HTA9_1_11888", "HTA9_1_11889", "HTA9_1_11890", "HTA9_1_11891", "HTA9_1_11892", "HTA9_1_11893", "HTA9_1_11894", "HTA9_1_11895", "HTA9_1_11896", "HTA9_1_11897", "HTA9_1_11898", "HTA9_1_11899", "HTA9_1_11900", "HTA9_1_11902", "HTA9_1_11904", "HTA9_1_11905", "HTA9_1_11906", "HTA9_1_11907", "HTA9_1_11909", "HTA9_1_11910", "HTA9_1_11911", "HTA9_1_11912", "HTA9_1_11913", "HTA9_1_11914", "HTA9_1_11915", "HTA9_1_11917", "HTA9_1_11918", "HTA9_1_11919", "HTA9_1_11920", "HTA9_1_11921", "HTA9_1_11922", "HTA9_1_11923", "HTA9_1_11924", "HTA9_1_11925", "HTA9_1_11926", "HTA9_1_11928", "HTA9_1_11929", "HTA9_1_11930", "HTA9_1_11931", "HTA9_1_11932", "HTA9_1_11933", "HTA9_1_11934", "HTA9_1_11935", "HTA9_1_11936", "HTA9_1_11937", "HTA9_1_11938", "HTA9_1_11939", "HTA9_1_11941", "HTA9_1_11942", "HTA9_1_11944", "HTA9_1_11945", "HTA9_1_11946", "HTA9_1_11947", "HTA9_1_11948", "HTA9_1_11949", "HTA9_1_11950", "HTA9_1_11951", "HTA9_1_11952", "HTA9_1_11953", "HTA9_1_11954", "HTA9_1_11956", "HTA9_1_11957", "HTA9_1_11959", "HTA9_1_11961", "HTA9_1_11962", "HTA9_1_11963", "HTA9_1_11964", "HTA9_1_11965", "HTA9_1_11966", "HTA9_1_11968", "HTA9_1_11969", "HTA9_1_11971", "HTA9_1_11972", "HTA9_1_11973", "HTA9_1_11974", "HTA9_1_11975", "HTA9_1_11976", "HTA9_1_11978", "HTA9_1_11979", "HTA9_1_11980", "HTA9_1_11981", "HTA9_1_11982", "HTA9_1_11983", "HTA9_1_11984", "HTA9_1_11986", "HTA9_1_11987", "HTA9_1_11988", "HTA9_1_11989", "HTA9_1_11990", "HTA9_1_11991", "HTA9_1_11992", "HTA9_1_11994", "HTA9_1_11996", "HTA9_1_11998", "HTA9_1_11999", "HTA9_1_12000", "HTA9_1_12001", "HTA9_1_12002", "HTA9_1_12003", "HTA9_1_12004", "HTA9_1_12006", "HTA9_1_12007", "HTA9_1_12008", "HTA9_1_12009", "HTA9_1_12011", "HTA9_1_12012", "HTA9_1_12014", "HTA9_1_12015", "HTA9_1_12016", "HTA9_1_12017", "HTA9_1_12018", "HTA9_1_12020", "HTA9_1_12021", "HTA9_1_12022", "HTA9_1_12023", "HTA9_1_12024", "HTA9_1_12025", "HTA9_1_12026", "HTA9_1_12027", "HTA9_1_12028", "HTA9_1_12029", "HTA9_1_12030", "HTA9_1_12031", "HTA9_1_12032", "HTA9_1_12033", "HTA9_1_12034", "HTA9_1_12035", "HTA9_1_12036", "HTA9_1_12037", "HTA9_1_12038", "HTA9_1_12039", "HTA9_1_12041", "HTA9_1_12042", "HTA9_1_12044", "HTA9_1_12045", "HTA9_1_12046", "HTA9_1_12047", "HTA9_1_12048", "HTA9_1_12049", "HTA9_1_12050", "HTA9_1_12051", "HTA9_1_12052", "HTA9_1_12053", "HTA9_1_12055", "HTA9_1_12056", "HTA9_1_12057", "HTA9_1_12058", "HTA9_1_12059", "HTA9_1_12060", "HTA9_1_12061", "HTA9_1_12062", "HTA9_1_12064", "HTA9_1_12065", "HTA9_1_12066", "HTA9_1_12067", "HTA9_1_12068", "HTA9_1_12069", "HTA9_1_12070", "HTA9_1_12071", "HTA9_1_12072", "HTA9_1_12073", "HTA9_1_12074", "HTA9_1_12077", "HTA9_1_12079", "HTA9_1_12080", "HTA9_1_12082", "HTA9_1_12083", "HTA9_1_12084", "HTA9_1_12085", "HTA9_1_12086", "HTA9_1_12087", "HTA9_1_12088", "HTA9_1_12089", "HTA9_1_12090", "HTA9_1_12092", "HTA9_1_12093", "HTA9_1_12094", "HTA9_1_12095", "HTA9_1_12096", "HTA9_1_12099", "HTA9_1_12101", "HTA9_1_12102", "HTA9_1_12104", "HTA9_1_12105", "HTA9_1_12106", "HTA9_1_12107", "HTA9_1_12108", "HTA9_1_12109", "HTA9_1_12110", "HTA9_1_12111", "HTA9_1_12112", "HTA9_1_12113", "HTA9_1_12114", "HTA9_1_12116", "HTA9_1_12117", "HTA9_1_12118", "HTA9_1_12119", "HTA9_1_12121", "HTA9_1_12124", "HTA9_1_12125", "HTA9_1_12126", "HTA9_1_12127", "HTA9_1_12128", "HTA9_1_12130", "HTA9_1_12132", "HTA9_1_12133", "HTA9_1_12134", "HTA9_1_12135", "HTA9_1_12136", "HTA9_1_12137", "HTA9_1_12140", "HTA9_1_12141", "HTA9_1_12142", "HTA9_1_12145", "HTA9_1_12146", "HTA9_1_12148", "HTA9_1_12149", "HTA9_1_12150", "HTA9_1_12152", "HTA9_1_12154", "HTA9_1_12155", "HTA9_1_12156", "HTA9_1_12158", "HTA9_1_12161", "HTA9_1_12163", "HTA9_1_12165", "HTA9_1_12166", "HTA9_1_12167", "HTA9_1_12168", "HTA9_1_12169", "HTA9_1_12170", "HTA9_1_12171", "HTA9_1_12173", "HTA9_1_12174", "HTA9_1_12176", "HTA9_1_12177", "HTA9_1_12178", "HTA9_1_12179", "HTA9_1_12180", "HTA9_1_12182", "HTA9_1_12183", "HTA9_1_12184", "HTA9_1_12185", "HTA9_1_12186", "HTA9_1_12188", "HTA9_1_12189", "HTA9_1_12191", "HTA9_1_12192", "HTA9_1_12193", "HTA9_1_12194", "HTA9_1_12195", "HTA9_1_12196", "HTA9_1_12197", "HTA9_1_12198", "HTA9_1_12199", "HTA9_1_12201", "HTA9_1_12203", "HTA9_1_12205", "HTA9_1_12206", "HTA9_1_12207", "HTA9_1_12208", "HTA9_1_12209", "HTA9_1_12210", "HTA9_1_12212", "HTA9_1_12214", "HTA9_1_12216", "HTA9_1_12217", "HTA9_1_12218", "HTA9_1_12220", "HTA9_1_12221", "HTA9_1_12222", "HTA9_1_12223", "HTA9_1_12224", "HTA9_1_12225", "HTA9_1_12226", "HTA9_1_12227", "HTA9_1_12229", "HTA9_1_12230", "HTA9_1_12233", "HTA9_1_12235", "HTA9_1_12237", "HTA9_1_12238", "HTA9_1_12239", "HTA9_1_12241", "HTA9_1_12242", "HTA9_1_12243", "HTA9_1_12244", "HTA9_1_12245", "HTA9_1_12246", "HTA9_1_12247", "HTA9_1_12249", "HTA9_1_12250", "HTA9_1_12251", "HTA9_1_12252", "HTA9_1_12253", "HTA9_1_12255", "HTA9_1_12256", "HTA9_1_12257", "HTA9_1_12258", "HTA9_1_12259", "HTA9_1_12260", "HTA9_1_12261", "HTA9_1_12262", "HTA9_1_12263", "HTA9_1_12264", "HTA9_1_12265", "HTA9_1_12266", "HTA9_1_12267", "HTA9_1_12268", "HTA9_1_12269", "HTA9_1_12270", "HTA9_1_12273", "HTA9_1_12274", "HTA9_1_12277", "HTA9_1_12278", "HTA9_1_12279", "HTA9_1_12281", "HTA9_1_12282", "HTA9_1_12283", "HTA9_1_12284", "HTA9_1_12285", "HTA9_1_12287", "HTA9_1_12288", "HTA9_1_12290", "HTA9_1_12291", "HTA9_1_12292", "HTA9_1_12293", "HTA9_1_12294", "HTA9_1_12296", "HTA9_1_12297", "HTA9_1_12299", "HTA9_1_12301", "HTA9_1_12302", "HTA9_1_12303", "HTA9_1_12304", "HTA9_1_12305", "HTA9_1_12306", "HTA9_1_12307", "HTA9_1_12308", "HTA9_1_12309", "HTA9_1_12310", "HTA9_1_12311", "HTA9_1_12312", "HTA9_1_12313", "HTA9_1_12314", "HTA9_1_12316", "HTA9_1_12317", "HTA9_1_12318", "HTA9_1_12319", "HTA9_1_12321", "HTA9_1_12323", "HTA9_1_12324", "HTA9_1_12325", "HTA9_1_12326", "HTA9_1_12327", "HTA9_1_12328", "HTA9_1_12329", "HTA9_1_12331", "HTA9_1_12332", "HTA9_1_12333", "HTA9_1_12334", "HTA9_1_12335", "HTA9_1_12336", "HTA9_1_12337", "HTA9_1_12338", "HTA9_1_12339", "HTA9_1_12340", "HTA9_1_12341", "HTA9_1_12342", "HTA9_1_12343", "HTA9_1_12344", "HTA9_1_12346", "HTA9_1_12347", "HTA9_1_12348", "HTA9_1_12349", "HTA9_1_12350", "HTA9_1_12351", "HTA9_1_12352", "HTA9_1_12353", "HTA9_1_12354", "HTA9_1_12355", "HTA9_1_12356", "HTA9_1_12357", "HTA9_1_12358", "HTA9_1_12359", "HTA9_1_12360", "HTA9_1_12361", "HTA9_1_12362", "HTA9_1_12363", "HTA9_1_12364", "HTA9_1_12365", "HTA9_1_12366", "HTA9_1_12367", "HTA9_1_12369", "HTA9_1_12370", "HTA9_1_12371", "HTA9_1_12372", "HTA9_1_12373", "HTA9_1_12374", "HTA9_1_12375", "HTA9_1_12376", "HTA9_1_12378", "HTA9_1_12379", "HTA9_1_12380", "HTA9_1_12381", "HTA9_1_12382", "HTA9_1_12383", "HTA9_1_12384", "HTA9_1_12385", "HTA9_1_12386", "HTA9_1_12387", "HTA9_1_12388", "HTA9_1_12391", "HTA9_1_12393", "HTA9_1_12394", "HTA9_1_12395", "HTA9_1_12396", "HTA9_1_12397", "HTA9_1_12398", "HTA9_1_12399", "HTA9_1_12400", "HTA9_1_12401", "HTA9_1_12403", "HTA9_1_12404", "HTA9_1_12405", "HTA9_1_12406", "HTA9_1_12407", "HTA9_1_12408", "HTA9_1_12409", "HTA9_1_12410", "HTA9_1_12411", "HTA9_1_12412", "HTA9_1_12413", "HTA9_1_12414", "HTA9_1_12416", "HTA9_1_12417", "HTA9_1_12418", "HTA9_1_12419", "HTA9_1_12420", "HTA9_1_12421", "HTA9_1_12422", "HTA9_1_12423", "HTA9_1_12424", "HTA9_1_12426", "HTA9_1_12427", "HTA9_1_12428", "HTA9_1_12429", "HTA9_1_12430", "HTA9_1_12431", "HTA9_1_12432", "HTA9_1_12433", "HTA9_1_12434", "HTA9_1_12435", "HTA9_1_12436", "HTA9_1_12437", "HTA9_1_12438", "HTA9_1_12439", "HTA9_1_12441", "HTA9_1_12443", "HTA9_1_12444", "HTA9_1_12445", "HTA9_1_12447", "HTA9_1_12448", "HTA9_1_12449", "HTA9_1_12450", "HTA9_1_12451", "HTA9_1_12452", "HTA9_1_12453", "HTA9_1_12454", "HTA9_1_12455", "HTA9_1_12456", "HTA9_1_12457", "HTA9_1_12459", "HTA9_1_12460", "HTA9_1_12461", "HTA9_1_12462", "HTA9_1_12463", "HTA9_1_12464", "HTA9_1_12466", "HTA9_1_12467", "HTA9_1_12469", "HTA9_1_12470", "HTA9_1_12472", "HTA9_1_12473", "HTA9_1_12474", "HTA9_1_12476", "HTA9_1_12477", "HTA9_1_12478", "HTA9_1_12479", "HTA9_1_12480", "HTA9_1_12481", "HTA9_1_12483", "HTA9_1_12484", "HTA9_1_12485", "HTA9_1_12486", "HTA9_1_12487", "HTA9_1_12489", "HTA9_1_12490", "HTA9_1_12491", "HTA9_1_12492", "HTA9_1_12493", "HTA9_1_12495", "HTA9_1_12496", "HTA9_1_12497", "HTA9_1_12498", "HTA9_1_12499", "HTA9_1_12500", "HTA9_1_12501", "HTA9_1_12502", "HTA9_1_12504", "HTA9_1_12505", "HTA9_1_12506", "HTA9_1_12507", "HTA9_1_12508", "HTA9_1_12511", "HTA9_1_12512", "HTA9_1_12513", "HTA9_1_12514", "HTA9_1_12515", "HTA9_1_12517", "HTA9_1_12518", "HTA9_1_12519", "HTA9_1_12520", "HTA9_1_12521", "HTA9_1_12522", "HTA9_1_12523", "HTA9_1_12524", "HTA9_1_12525", "HTA9_1_12526", "HTA9_1_12527", "HTA9_1_12528", "HTA9_1_12529", "HTA9_1_12530", "HTA9_1_12531", "HTA9_1_12533", "HTA9_1_12534", "HTA9_1_12535", "HTA9_1_12537", "HTA9_1_12539", "HTA9_1_12540", "HTA9_1_12541", "HTA9_1_12543", "HTA9_1_12544", "HTA9_1_12545", "HTA9_1_12547", "HTA9_1_12550", "HTA9_1_12551", "HTA9_1_12552", "HTA9_1_12554", "HTA9_1_12556", "HTA9_1_12557", "HTA9_1_12558", "HTA9_1_12559", "HTA9_1_12560", "HTA9_1_12562", 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"HTA9_1_14116", "HTA9_1_14117", "HTA9_1_14119", "HTA9_1_14120", "HTA9_1_14121", "HTA9_1_14122", "HTA9_1_14123", "HTA9_1_14124", "HTA9_1_14125", "HTA9_1_14126", "HTA9_1_14127", "HTA9_1_14129", "HTA9_1_14130", "HTA9_1_14132", "HTA9_1_14133", "HTA9_1_14134", "HTA9_1_14135", "HTA9_1_14136", "HTA9_1_14137", "HTA9_1_14140", "HTA9_1_14142", "HTA9_1_14143", "HTA9_1_14145", "HTA9_1_14146", "HTA9_1_14147", "HTA9_1_14148", "HTA9_1_14149", "HTA9_1_14150", "HTA9_1_14151", "HTA9_1_14154", "HTA9_1_14155", "HTA9_1_14156", "HTA9_1_14157", "HTA9_1_14159", "HTA9_1_14160", "HTA9_1_14161", "HTA9_1_14162", "HTA9_1_14164", "HTA9_1_14165", "HTA9_1_14166", "HTA9_1_14167", "HTA9_1_14168", "HTA9_1_14170", "HTA9_1_14171", "HTA9_1_14172", "HTA9_1_14173", "HTA9_1_14175", "HTA9_1_14177", "HTA9_1_14178", "HTA9_1_14180", "HTA9_1_14181", "HTA9_1_14182", "HTA9_1_14183", "HTA9_1_14184", "HTA9_1_14185", "HTA9_1_14186", "HTA9_1_14187", "HTA9_1_14188", "HTA9_1_14190", "HTA9_1_14191", "HTA9_1_14192", "HTA9_1_14193", 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"HTA9_1_19551", "HTA9_1_19552", "HTA9_1_19553", "HTA9_1_19554", "HTA9_1_19555", "HTA9_1_19556", "HTA9_1_19557", "HTA9_1_19558", "HTA9_1_19559", "HTA9_1_19560", "HTA9_1_19561", "HTA9_1_19562", "HTA9_1_19563", "HTA9_1_19564", "HTA9_1_19565", "HTA9_1_19566", "HTA9_1_19567", "HTA9_1_19568", "HTA9_1_19569", "HTA9_1_19570", "HTA9_1_19571", "HTA9_1_19572", "HTA9_1_19573", "HTA9_1_19574", "HTA9_1_19575", "HTA9_1_19576", "HTA9_1_19577", "HTA9_1_19578", "HTA9_1_19579", "HTA9_1_19580", "HTA9_1_19581", "HTA9_1_19582", "HTA9_1_19583", "HTA9_1_19584", "HTA9_1_19585", "HTA9_1_19586", "HTA9_1_19587", "HTA9_1_19588", "HTA9_1_19589", "HTA9_1_19590", "HTA9_1_19591", "HTA9_1_19592", "HTA9_1_19593", "HTA9_1_19594", "HTA9_1_19595", "HTA9_1_19596", "HTA9_1_19597", "HTA9_1_19598", "HTA9_1_19599", "HTA9_1_19600", "HTA9_1_19601", "HTA9_1_19602", "HTA9_1_19603", "HTA9_1_19604", "HTA9_1_19605", "HTA9_1_19606", "HTA9_1_19607", "HTA9_1_19608", "HTA9_1_19609", "HTA9_1_19610", "HTA9_1_19611", "HTA9_1_19612", 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"HTA9_1_19678", "HTA9_1_19679", "HTA9_1_19680", "HTA9_1_19681", "HTA9_1_19682", "HTA9_1_19683", "HTA9_1_19684", "HTA9_1_19685", "HTA9_1_19686", "HTA9_1_19687", "HTA9_1_19688", "HTA9_1_19749", "HTA9_1_19750", "HTA9_1_19751", "HTA9_1_19752", "HTA9_1_19753", "HTA9_1_19754", "HTA9_1_19755", "HTA9_1_19756", "HTA9_1_19757", "HTA9_1_19758", "HTA9_1_19759", "HTA9_1_19760", "HTA9_1_19761", "HTA9_1_19762", "HTA9_1_19763", "HTA9_1_19764", "HTA9_1_19765", "HTA9_1_19766", "HTA9_1_19767", "HTA9_1_19768", "HTA9_1_19769", "HTA9_1_19770", "HTA9_1_19771", "HTA9_1_19772", "HTA9_1_19773", "HTA9_1_19774", "HTA9_1_19775", "HTA9_1_19776", "HTA9_1_19777", "HTA9_1_19778", "HTA9_1_19779", "HTA9_1_19780", "HTA9_1_19781", "HTA9_1_19782", "HTA9_1_19783", "HTA9_1_19784", "HTA9_1_19785", "HTA9_1_19786", "HTA9_1_19787", "HTA9_1_19788", "HTA9_1_19789", "HTA9_1_19790", "HTA9_1_19791", "HTA9_1_19792", "HTA9_1_19793", "HTA9_1_19794", "HTA9_1_19795", "HTA9_1_19796", "HTA9_1_19797", "HTA9_1_19798", "HTA9_1_19799", "HTA9_1_19800", "HTA9_1_19801", "HTA9_1_19802", "HTA9_1_19803", "HTA9_1_19804", "HTA9_1_19805", "HTA9_1_19806", "HTA9_1_19807", "HTA9_1_19808", "HTA9_1_19809", "HTA9_1_19810", "HTA9_1_19811", "HTA9_1_19812", "HTA9_1_19813", "HTA9_1_19814", "HTA9_1_19815", "HTA9_1_19816", "HTA9_1_19817", "HTA9_1_19818", "HTA9_1_19819", "HTA9_1_19820", "HTA9_1_19821", "HTA9_1_19822", "HTA9_1_19823", "HTA9_1_19824", "HTA9_1_19825", "HTA9_1_19826", "HTA9_1_19827", "HTA9_1_19828", "HTA9_1_19829", "HTA9_1_19830", "HTA9_1_19831", "HTA9_1_19832", "HTA9_1_19833", "HTA9_1_19834", "HTA9_1_19835", "HTA9_1_19836", "HTA9_1_19837", "HTA9_1_19838", "HTA9_1_19839", "HTA9_1_19840", "HTA9_1_19841", "HTA9_1_19842", "HTA9_1_19843", "HTA9_1_19844", "HTA9_1_19845", "HTA9_1_19846", "HTA9_1_19847", "HTA9_1_19848", "HTA9_1_19849", "HTA9_1_19850", "HTA9_1_19851", "HTA9_1_19852", "HTA9_1_19853", "HTA9_1_19854", "HTA9_1_19855", "HTA9_1_19856", "HTA9_1_19857", "HTA9_1_19858", "HTA9_1_19859", "HTA9_1_19860", "HTA9_1_19861", "HTA9_1_19862", "HTA9_1_19863", "HTA9_1_19864", "HTA9_1_19865", "HTA9_1_19866", "HTA9_1_19867", "HTA9_1_19868", "HTA9_1_19869", "HTA9_1_19870", "HTA9_1_19871", "HTA9_1_19872", "HTA9_1_19873", "HTA9_1_19874", "HTA9_1_19875", "HTA9_1_19876", "HTA9_1_19877", "HTA9_1_19878", "HTA9_1_19879", "HTA9_1_19880", "HTA9_1_19881", "HTA9_1_19882", "HTA9_1_19883", "HTA9_1_19884", "HTA9_1_19885", "HTA9_1_19886", "HTA9_1_19887", "HTA9_1_19888", "HTA9_1_19889", "HTA9_1_19890", "HTA9_1_19891", "HTA9_1_19892", "HTA9_1_19893", "HTA9_1_19894", "HTA9_1_19895", "HTA9_1_19896", "HTA9_1_19897", "HTA9_1_19898", "HTA9_1_19899", "HTA9_1_19900", "HTA9_1_19901", "HTA9_1_19902", "HTA9_1_19903", "HTA9_1_19904", "HTA9_1_19905", "HTA9_1_19906", "HTA9_1_19907", "HTA9_1_19908", "HTA9_1_19909", "HTA9_1_19910", "HTA9_1_19911", "HTA9_1_19912", "HTA9_1_19913", "HTA9_1_19914", "HTA9_1_19915", "HTA9_1_19916", "HTA9_1_19917", "HTA9_1_19918", "HTA9_1_19919", "HTA9_1_19920", "HTA9_1_19921", "HTA9_1_19922", "HTA9_1_19923", "HTA9_1_19924", "HTA9_1_19925", "HTA9_1_19926", "HTA9_1_19927", "HTA9_1_19928", "HTA9_1_19929", "HTA9_1_19930", "HTA9_1_19931", "HTA9_1_19932", "HTA9_1_19933", "HTA9_1_19934", "HTA9_1_19935", "HTA9_1_19936", "HTA9_1_19937", "HTA9_1_19938", "HTA9_1_19939", "HTA9_1_19940", "HTA9_1_19941", "HTA9_1_19942", "HTA9_1_19943", "HTA9_1_19944", "HTA9_1_19945", "HTA9_1_19946", "HTA9_1_19947", "HTA9_1_19948", "HTA9_1_19949", "HTA9_1_19950", "HTA9_1_19951", "HTA9_1_19952", "HTA9_1_19953", "HTA9_1_19954", "HTA9_1_19955", "HTA9_1_19956", "HTA9_1_19957", "HTA9_1_19958", "HTA9_1_19959", "HTA9_1_19960", "HTA9_1_19961", "HTA9_1_19962", "HTA9_1_19963", "HTA9_1_19964", "HTA9_1_19965", "HTA9_1_19966", "HTA9_1_19967", "HTA9_1_19968", "HTA9_1_19969", "HTA9_1_19970", "HTA9_1_19971", "HTA9_1_19972", "HTA9_1_19973", "HTA9_1_19974", "HTA9_1_19975", "HTA9_1_19976", "HTA9_1_19977", "HTA9_1_19978", "HTA9_1_19979", "HTA9_1_19980", "HTA9_1_19981", "HTA9_1_19982", "HTA9_1_19983", "HTA9_1_19984", "HTA9_1_19985", "HTA9_1_19986", "HTA9_1_19987", "HTA9_1_19988", "HTA9_1_19989", "HTA9_1_19990", "HTA9_1_19991", "HTA9_1_19992", "HTA9_1_19993", "HTA9_1_19994", "HTA9_1_19995", "HTA9_1_19996", "HTA9_1_19997", "HTA9_1_19998", "HTA9_1_19999", "HTA9_1_20000", "HTA9_1_20001", "HTA9_1_20002", "HTA9_1_20003", "HTA9_1_20004", "HTA9_1_20005", "HTA9_1_20006", "HTA9_1_20007", "HTA9_1_20008", "HTA9_1_20009", "HTA9_1_20010", "HTA9_1_20011", "HTA9_1_20012", "HTA9_1_20013", "HTA9_1_20014", "HTA9_1_20015", "HTA9_1_20016", "HTA9_1_20017", "HTA9_1_20018", "HTA9_1_20019", "HTA9_1_20020", "HTA9_1_20021", "HTA9_1_20022", "HTA9_1_20023", "HTA9_1_20024", "HTA9_1_20025", "HTA9_1_20026", "HTA9_1_20027", "HTA9_1_20028", "HTA9_1_20029", "HTA9_1_20030", "HTA9_1_20031", "HTA9_1_20032", "HTA9_1_20033", "HTA9_1_20034", "HTA9_1_20035", "HTA9_1_20036", "HTA9_1_20037", "HTA9_1_20038", "HTA9_1_20039", "HTA9_1_20040", "HTA9_1_20041", "HTA9_1_20042", "HTA9_1_20043", "HTA9_1_20044", "HTA9_1_20045", "HTA9_1_20046", "HTA9_1_20047", "HTA9_1_20048", "HTA9_1_20049", "HTA9_1_20050", "HTA9_1_20051", "HTA9_1_20052", "HTA9_1_20053", "HTA9_1_20054", "HTA9_1_20055", "HTA9_1_20056", "HTA9_1_20057", "HTA9_1_20058", "HTA9_1_20059", "HTA9_1_20060", "HTA9_1_20061", "HTA9_1_20062", "HTA9_1_20063", "HTA9_1_20064", "HTA9_1_20065", "HTA9_1_20066", "HTA9_1_20067", "HTA9_1_20068", "HTA9_1_20069", "HTA9_1_20070", "HTA9_1_20071", "HTA9_1_20072", "HTA9_1_20073", "HTA9_1_20074", "HTA9_1_20075", "HTA9_1_20076", "HTA9_1_20077", "HTA9_1_20078", "HTA9_1_20079", "HTA9_1_20080", "HTA9_1_20081", "HTA9_1_20082", "HTA9_1_20083", "HTA9_1_20084", "HTA9_1_20085", "HTA9_1_20086", "HTA9_1_20087", "HTA9_1_20088", "HTA9_1_20089", "HTA9_1_20090", "HTA9_1_20091", "HTA9_1_20092", "HTA9_1_20093", "HTA9_1_20094", "HTA9_1_20095", "HTA9_1_20096", "HTA9_1_20097", "HTA9_1_20098", "HTA9_1_20099", "HTA9_1_20100", "HTA9_1_20101", "HTA9_1_20102", "HTA9_1_20103", "HTA9_1_20104", "HTA9_1_20105", "HTA9_1_20106", "HTA9_1_20107", "HTA9_1_20108", "HTA9_1_20109", "HTA9_1_20110", "HTA9_1_20111", "HTA9_1_20112", "HTA9_1_20113", "HTA9_1_20114", "HTA9_1_20115", "HTA9_1_20116", "HTA9_1_20117", "HTA9_1_20118", "HTA9_1_20119", "HTA9_1_20120", "HTA9_1_20121", "HTA9_1_20122", "HTA9_1_20123", "HTA9_1_20124", "HTA9_1_20125", "HTA9_1_20126", "HTA9_1_20127", "HTA9_1_20128", "HTA9_1_20129", "HTA9_1_20130", "HTA9_1_20131", "HTA9_1_20132", "HTA9_1_20133", "HTA9_1_20134", "HTA9_1_20135", "HTA9_1_20136", "HTA9_1_20137", "HTA9_1_20138", "HTA9_1_20139", "HTA9_1_20140", "HTA9_1_20141", "HTA9_1_20142", "HTA9_1_20143", "HTA9_1_20144", "HTA9_1_20145", "HTA9_1_20146", "HTA9_1_20147", "HTA9_1_20148", "HTA9_1_20149", "HTA9_1_20150", "HTA9_1_20151", "HTA9_1_20152", "HTA9_1_20153", "HTA9_1_20154", "HTA9_1_20155", "HTA9_1_20156", "HTA9_1_20157", "HTA9_1_20158", "HTA9_1_20159", "HTA9_1_20160", "HTA9_1_20161", "HTA9_1_20162", "HTA9_1_20163", "HTA9_1_20164", "HTA9_1_20165", "HTA9_1_20166", "HTA9_1_20167", "HTA9_1_20168", "HTA9_1_20169", "HTA9_1_20170", "HTA9_1_20171", "HTA9_1_20172", "HTA9_1_20173", "HTA9_1_20174", "HTA9_1_20175", "HTA9_1_20176", "HTA9_1_20177", "HTA9_1_20178", "HTA9_1_20179", "HTA9_1_20180", "HTA9_1_20181", "HTA9_1_20182", "HTA9_1_20183", "HTA9_1_20184", "HTA9_1_20185", "HTA9_1_20186", "HTA9_1_20187", "HTA9_1_20188", "HTA9_1_20189", "HTA9_1_20190", "HTA9_1_20191", "HTA9_1_20192", "HTA9_1_20193", "HTA9_1_20194", "HTA9_1_20195", "HTA9_1_20196", "HTA9_1_20197", "HTA9_1_20198", "HTA9_1_20199", "HTA9_1_20200", "HTA9_1_20201", "HTA9_1_20202", "HTA9_1_20203", "HTA9_1_20204", "HTA9_1_20205", "HTA9_1_20206", "HTA9_1_20207", "HTA9_1_20208", "HTA9_1_20209", "HTA9_1_20210", "HTA9_1_20211", "HTA9_1_20212", "HTA9_1_20213", "HTA9_1_20214", "HTA9_1_20215", "HTA9_1_20216", "HTA9_1_20217", "HTA9_1_20218", "HTA9_1_20219", "HTA9_1_20220", "HTA9_1_20221", "HTA9_1_20222", "HTA9_1_20223", "HTA9_1_20224", "HTA9_1_20225", "HTA9_1_20226", "HTA9_1_20227", "HTA9_1_20228", "HTA9_1_20229", "HTA9_1_20230", "HTA9_1_20231", "HTA9_1_20232", "HTA9_1_20233", "HTA9_1_20234", "HTA9_1_20235", "HTA9_1_20236", "HTA9_1_20237", "HTA9_1_20238", "HTA9_1_20239", "HTA9_1_20240", "HTA9_1_20241", "HTA9_1_20242", "HTA9_1_20243", "HTA9_1_20244", "HTA9_1_20245", "HTA9_1_20246", "HTA9_1_20247", "HTA9_1_20248", "HTA9_1_20249", "HTA9_1_20250", "HTA9_1_20251", "HTA9_1_20252", "HTA9_1_20253", "HTA9_1_20254", "HTA9_1_20255", "HTA9_1_20256", "HTA9_1_20257", "HTA9_1_20258", "HTA9_1_20259", "HTA9_1_20260", "HTA9_1_20261", "HTA9_1_20262", "HTA9_1_20263", "HTA9_1_20264", "HTA9_1_20265", "HTA9_1_20266", "HTA9_1_20267", "HTA9_1_20268", "HTA9_1_20269", "HTA9_1_20270", "HTA9_1_20271", "HTA9_1_20272", "HTA9_1_20273", "HTA9_1_20274", "HTA9_1_20275", "HTA9_1_20276", "HTA9_1_20277", "HTA9_1_20278", "HTA9_1_20279", "HTA9_1_20280", "HTA9_1_20281", "HTA9_1_20282", "HTA9_1_20283", "HTA9_1_20284", "HTA9_1_20285", "HTA9_1_20286", "HTA9_1_20287", "HTA9_1_20288", "HTA9_1_20289", "HTA9_1_20290", "HTA9_1_20291", "HTA9_1_20292", "HTA9_1_20293", "HTA9_1_20294", "HTA9_1_20295", "HTA9_1_20296", "HTA9_1_20297", "HTA9_1_20298", "HTA9_1_20299", "HTA9_1_20300", "HTA9_1_20301", "HTA9_1_20302", "HTA9_1_20303", "HTA9_1_20304", "HTA9_1_20305", "HTA9_1_20306", "HTA9_1_20307", "HTA9_1_20308", "HTA9_1_20309", "HTA9_1_20310", "HTA9_1_20311", "HTA9_1_20312", "HTA9_1_20313", "HTA9_1_20314", "HTA9_1_20315", "HTA9_1_20316", "HTA9_1_20317", "HTA9_1_20318", "HTA9_1_20319", "HTA9_1_20320", "HTA9_1_20321", "HTA9_1_20322", "HTA9_1_20323", "HTA9_1_20324", "HTA9_1_20325", "HTA9_1_20326", "HTA9_1_20327", "HTA9_1_20328", "HTA9_1_20329", "HTA9_1_20330", "HTA9_1_20331", "HTA9_1_20332", "HTA9_1_20333", "HTA9_1_20334", "HTA9_1_20335", "HTA9_1_20336", "HTA9_1_20337", "HTA9_1_20338", "HTA9_1_20339", "HTA9_1_20340", "HTA9_1_20341", "HTA9_1_20342", "HTA9_1_20343", "HTA9_1_20344", "HTA9_1_20345", "HTA9_1_20346", "HTA9_1_20347", "HTA9_1_20348", "HTA9_1_20349", "HTA9_1_20350", "HTA9_1_20351", "HTA9_1_20352", "HTA9_1_20353", "HTA9_1_20354", "HTA9_1_20355", "HTA9_1_20356", "HTA9_1_20357", "HTA9_1_20358", "HTA9_1_20359", "HTA9_1_20360", "HTA9_1_20361", "HTA9_1_20362", "HTA9_1_20363", "HTA9_1_20364", "HTA9_1_20365", "HTA9_1_20366", "HTA9_1_20367", "HTA9_1_20368", "HTA9_1_20369", "HTA9_1_20370", "HTA9_1_20371", "HTA9_1_20372", "HTA9_1_20373", "HTA9_1_20374", "HTA9_1_20375", "HTA9_1_20376", "HTA9_1_20377", "HTA9_1_20378", "HTA9_1_20379", "HTA9_1_20380", "HTA9_1_20381", "HTA9_1_20382", "HTA9_1_20383", "HTA9_1_20384", "HTA9_1_20385", "HTA9_1_20386", "HTA9_1_20387", "HTA9_1_20388", "HTA9_1_20389", "HTA9_1_20390", "HTA9_1_20391", "HTA9_1_20392", "HTA9_1_20393", "HTA9_1_20394", "HTA9_1_20395", "HTA9_1_20396", "HTA9_1_20397", "HTA9_1_20398", "HTA9_1_20399", "HTA9_1_20400", "HTA9_1_20401", "HTA9_1_20402", "HTA9_1_20403", "HTA9_1_20404", "HTA9_1_20405", "HTA9_1_20406", "HTA9_1_20407", "HTA9_1_20408", "HTA9_1_20409", "HTA9_1_20410", "HTA9_1_20411", "HTA9_1_20412", "HTA9_1_20413", "HTA9_1_20414", "HTA9_1_20415", "HTA9_1_20416", "HTA9_1_20417", "HTA9_1_20418", "HTA9_1_20419", "HTA9_1_20420", "HTA9_1_20421", "HTA9_1_20422", "HTA9_1_20423", "HTA9_1_20424", "HTA9_1_20425", "HTA9_1_20426", "HTA9_1_20427", "HTA9_1_20428", "HTA9_1_20429", "HTA9_1_20430", "HTA9_1_20431", "HTA9_1_20432", "HTA9_1_20433", "HTA9_1_20434", "HTA9_1_20435", "HTA9_1_20436", "HTA9_1_20437", "HTA9_1_20438", "HTA9_1_20439", "HTA9_1_20440", "HTA9_1_20441", "HTA9_1_20442", "HTA9_1_20443", "HTA9_1_20444", "HTA9_1_20445", "HTA9_1_20446", "HTA9_1_20447", "HTA9_1_20448", "HTA9_1_20449", "HTA9_1_20450", "HTA9_1_20451", "HTA9_1_20452", "HTA9_1_20453", "HTA9_1_20454", "HTA9_1_20455", "HTA9_1_20456", "HTA9_1_20457", "HTA9_1_20458", "HTA9_1_20459", "HTA9_1_20460", "HTA9_1_20461", "HTA9_1_20462", "HTA9_1_20463", "HTA9_1_20464", "HTA9_1_20465", "HTA9_1_20466", "HTA9_1_20467", "HTA9_1_20468", "HTA9_1_20469", "HTA9_1_20470", "HTA9_1_20471", "HTA9_1_20472", "HTA9_1_20473", "HTA9_1_20474", "HTA9_1_20475", "HTA9_1_20476", "HTA9_1_20477", "HTA9_1_20478", "HTA9_1_20479", "HTA9_1_20480", "HTA9_1_20481", "HTA9_1_20482", "HTA9_1_20483", "HTA9_1_20484", "HTA9_1_20485", "HTA9_1_20486", "HTA9_1_20487", "HTA9_1_20488", "HTA9_1_20489", "HTA9_1_20490", "HTA9_1_20491", "HTA9_1_20492", "HTA9_1_20493", "HTA9_1_20494", "HTA9_1_20495", "HTA9_1_20496", "HTA9_1_20497", "HTA9_1_20498", "HTA9_1_20499", "HTA9_1_20500", "HTA9_1_20501", "HTA9_1_20502", "HTA9_1_20503", "HTA9_1_20504", "HTA9_1_20505", "HTA9_1_20506", "HTA9_1_20507", "HTA9_1_20508", "HTA9_1_20509", "HTA9_1_20510", "HTA9_1_20511", "HTA9_1_20512", "HTA9_1_20513", "HTA9_1_20514", "HTA9_1_20515", "HTA9_1_20516", "HTA9_1_20517", "HTA9_1_20518", "HTA9_1_20519", "HTA9_1_20520", "HTA9_1_20521", "HTA9_1_20522", "HTA9_1_20523", "HTA9_1_20524", "HTA9_1_20525", "HTA9_1_20526", "HTA9_1_20527", "HTA9_1_20528", "HTA9_1_20529", "HTA9_1_20530", "HTA9_1_20531", "HTA9_1_20532", "HTA9_1_20533", "HTA9_1_20534", "HTA9_1_20535", "HTA9_1_20536", "HTA9_1_20537", "HTA9_1_20538", "HTA9_1_20539", "HTA9_1_20540", "HTA9_1_20541", "HTA9_1_20542", "HTA9_1_20543", "HTA9_1_20544", "HTA9_1_20545", "HTA9_1_20546", "HTA9_1_20547", "HTA9_1_20548", "HTA9_1_20549", "HTA9_1_20550", "HTA9_1_20551", "HTA9_1_20552", "HTA9_1_20553", "HTA9_1_20554", "HTA9_1_20555", "HTA9_1_20556", "HTA9_1_20557", "HTA9_1_20558", "HTA9_1_20559", "HTA9_1_20560", "HTA9_1_20561", "HTA9_1_20562", "HTA9_1_20563", "HTA9_1_20564", "HTA9_1_20565", "HTA9_1_20566", "HTA9_1_20567", "HTA9_1_20568", "HTA9_1_20569", "HTA9_1_20570", "HTA9_1_20571", "HTA9_1_20572", "HTA9_1_20573", "HTA9_1_20574", "HTA9_1_20575", "HTA9_1_20576", "HTA9_1_20577", "HTA9_1_20578", "HTA9_1_20579", "HTA9_1_20580", "HTA9_1_20581", "HTA9_1_20582", "HTA9_1_20583", "HTA9_1_20584", "HTA9_1_20585", "HTA9_1_20586", "HTA9_1_20587", "HTA9_1_20588", "HTA9_1_20589", "HTA9_1_20590", "HTA9_1_20591", "HTA9_1_20592", "HTA9_1_20593", "HTA9_1_20594", "HTA9_1_20595", "HTA9_1_20596", "HTA9_1_20597", "HTA9_1_20598", "HTA9_1_20599", "HTA9_1_20600", "HTA9_1_20601", "HTA9_1_20602", "HTA9_1_20603", "HTA9_1_20604", "HTA9_1_20605", "HTA9_1_20606", "HTA9_1_20607", "HTA9_1_20608", "HTA9_1_20609", "HTA9_1_20610", "HTA9_1_20611", "HTA9_1_20612", "HTA9_1_20613", "HTA9_1_20614", "HTA9_1_20615", "HTA9_1_20616", "HTA9_1_20617", "HTA9_1_20618", "HTA9_1_20619", "HTA9_1_20620", "HTA9_1_20621", "HTA9_1_20622", "HTA9_1_20623", "HTA9_1_20624", "HTA9_1_20625", "HTA9_1_20626", "HTA9_1_20627", "HTA9_1_20628", "HTA9_1_20629", "HTA9_1_20630", "HTA9_1_20631", "HTA9_1_20632", "HTA9_1_20633", "HTA9_1_20634", "HTA9_1_20635", "HTA9_1_20636", "HTA9_1_20637", "HTA9_1_20638", "HTA9_1_20639", "HTA9_1_20640", "HTA9_1_20641", "HTA9_1_20642", "HTA9_1_20643", "HTA9_1_20644", "HTA9_1_20645", "HTA9_1_20646", "HTA9_1_20647", "HTA9_1_20648", "HTA9_1_20649", "HTA9_1_20650", "HTA9_1_20651", "HTA9_1_20652", "HTA9_1_20653", "HTA9_1_20654", "HTA9_1_20655", "HTA9_1_20656", "HTA9_1_20657", "HTA9_1_20658", "HTA9_1_20659", "HTA9_1_20660", "HTA9_1_20661", "HTA9_1_20662", "HTA9_1_20663", "HTA9_1_20664", "HTA9_1_20665", "HTA9_1_20666", "HTA9_1_20667", "HTA9_1_20668", "HTA9_1_20669", "HTA9_1_20670", "HTA9_1_20671", "HTA9_1_20672", "HTA9_1_20673", "HTA9_1_20674", "HTA9_1_20675", "HTA9_1_20676", "HTA9_1_20677", "HTA9_1_20678", "HTA9_1_20679", "HTA9_1_20680", "HTA9_1_20681", "HTA9_1_20682", "HTA9_1_20683", "HTA9_1_20684", "HTA9_1_20685", "HTA9_1_20686", "HTA9_1_20687", "HTA9_1_20688", "HTA9_1_20689", "HTA9_1_20690", "HTA9_1_20691", "HTA9_1_20692", "HTA9_1_20693", "HTA9_1_20694", "HTA9_1_20695", "HTA9_1_20696", "HTA9_1_20697", "HTA9_1_20698", "HTA9_1_20699", "HTA9_1_20700", "HTA9_1_20701", "HTA9_1_20702", "HTA9_1_20703", "HTA9_1_20704", "HTA9_1_20705", "HTA9_1_20706", "HTA9_1_20707", "HTA9_1_20708", "HTA9_1_20709", "HTA9_1_20710", "HTA9_1_20711", "HTA9_1_20712", "HTA9_1_20713", "HTA9_1_20714", "HTA9_1_20715", "HTA9_1_20716", "HTA9_1_20717", "HTA9_1_20718", "HTA9_1_20719", "HTA9_1_20720", "HTA9_1_20721", "HTA9_1_20722", "HTA9_1_20723", "HTA9_1_20724", "HTA9_1_20725", "HTA9_1_20726", "HTA9_1_20727", "HTA9_1_20728", "HTA9_1_20729", "HTA9_1_20730", "HTA9_1_20731", "HTA9_1_20732", "HTA9_1_20733", "HTA9_1_20734", "HTA9_1_20735", "HTA9_1_20736", "HTA9_1_20737", "HTA9_1_20738", "HTA9_1_20739", "HTA9_1_20740", "HTA9_1_20741", "HTA9_1_20742", "HTA9_1_20743", "HTA9_1_20744", "HTA9_1_20745", "HTA9_1_20746", "HTA9_1_20747", "HTA9_1_20748", "HTA9_1_20749", "HTA9_1_20750", "HTA9_1_20751", "HTA9_1_20752", "HTA9_1_20753", "HTA9_1_20754", "HTA9_1_20755", "HTA9_1_20756", "HTA9_1_20757", "HTA9_1_20758", "HTA9_1_20759", "HTA9_1_20760", "HTA9_1_20761", "HTA9_1_20762", "HTA9_1_20763", "HTA9_1_20764", "HTA9_1_20765", "HTA9_1_20766", "HTA9_1_20767", "HTA9_1_20768", "HTA9_1_20769", "HTA9_1_20770", "HTA9_1_20771", "HTA9_1_20772", "HTA9_1_20773", "HTA9_1_20774", "HTA9_1_20775", "HTA9_1_20776", "HTA9_1_20777", "HTA9_1_20778", "HTA9_1_20779", "HTA9_1_20780", "HTA9_1_20781", "HTA9_1_20782", "HTA9_1_20783", "HTA9_1_20784", "HTA9_1_20785", "HTA9_1_20786", "HTA9_1_20787", "HTA9_1_20788", "HTA9_1_20789", "HTA9_1_20790", "HTA9_1_20791", "HTA9_1_20792", "HTA9_1_20793", "HTA9_1_20794", "HTA9_1_20795", "HTA9_1_20796", "HTA9_1_20797", "HTA9_1_20798", "HTA9_1_20799", "HTA9_1_20800", "HTA9_1_20801", "HTA9_1_20802", "HTA9_1_20803", "HTA9_1_20804", "HTA9_1_20805", "HTA9_1_20806", "HTA9_1_20807", "HTA9_1_20808", "HTA9_1_20809", "HTA9_1_20810", "HTA9_1_20811", "HTA9_1_20812", "HTA9_1_20813", "HTA9_1_20814", "HTA9_1_20815", "HTA9_1_20816", "HTA9_1_20817", "HTA9_1_20818", "HTA9_1_20819", "HTA9_1_20820", "HTA9_1_20821", "HTA9_1_20822", "HTA9_1_20823", "HTA9_1_20824", "HTA9_1_20825", "HTA9_1_20826", "HTA9_1_20827", "HTA9_1_20828", "HTA9_1_20829", "HTA9_1_20830", "HTA9_1_20831", "HTA9_1_20832", "HTA9_1_20833", "HTA9_1_20834", "HTA9_1_20835", "HTA9_1_20836", "HTA9_1_20837", "HTA9_1_20838", "HTA9_1_20839", "HTA9_1_20840", "HTA9_1_20841", "HTA9_1_20842", "HTA9_1_20843", "HTA9_1_20844", "HTA9_1_20845", "HTA9_1_20846", "HTA9_1_20847", "HTA9_1_20848", "HTA9_1_20849", "HTA9_1_20850", "HTA9_1_20851", "HTA9_1_20852", "HTA9_1_20853", "HTA9_1_20854", "HTA9_1_20855", "HTA9_1_20856", "HTA9_1_20857", "HTA9_1_20858", "HTA9_1_20859", "HTA9_1_20860", "HTA9_1_20861", "HTA9_1_20862", "HTA9_1_20863", "HTA9_1_20864", "HTA9_1_20865", "HTA9_1_20866", "HTA9_1_20867", "HTA9_1_20868", "HTA9_1_20869", "HTA9_1_20870", "HTA9_1_20871", "HTA9_1_20872", "HTA9_1_20873", "HTA9_1_20874", "HTA9_1_20875", "HTA9_1_20876", "HTA9_1_20877", "HTA9_1_20878", "HTA9_1_20879", "HTA9_1_20880", "HTA9_1_20881", "HTA9_1_20882", "HTA9_1_20883", "HTA9_1_20884", "HTA9_1_20885", "HTA9_1_20886", "HTA9_1_20887", "HTA9_1_20888", "HTA9_1_20889", "HTA9_1_20890", "HTA9_1_20891", "HTA9_1_20892", "HTA9_1_20893", "HTA9_1_20894", "HTA9_1_20895", "HTA9_1_20896", "HTA9_1_20897", "HTA9_1_20898", "HTA9_1_20899", "HTA9_1_20900", "HTA9_1_20901", "HTA9_1_20902", "HTA9_1_20903", "HTA9_1_20904", "HTA9_1_20905", "HTA9_1_20906", "HTA9_1_20907", "HTA9_1_20908", "HTA9_1_20909", "HTA9_1_20910", "HTA9_1_20911", "HTA9_1_20912", "HTA9_1_20913", "HTA9_1_20914", "HTA9_1_20915", "HTA9_1_20916", "HTA9_1_20917", "HTA9_1_20918", "HTA9_1_20919", "HTA9_1_20920", "HTA9_1_20921", "HTA9_1_20922", "HTA9_1_20923", "HTA9_1_20924", "HTA9_1_20925", "HTA9_1_20926", "HTA9_1_20927", "HTA9_1_20928", "HTA9_1_20929", "HTA9_1_20930", "HTA9_1_20931", "HTA9_1_20932", "HTA9_1_20933", "HTA9_1_20934", "HTA9_1_20935", "HTA9_1_20936", "HTA9_1_20937", "HTA9_1_20938", "HTA9_1_20939", "HTA9_1_20940", "HTA9_1_20941", "HTA9_1_20942", "HTA9_1_20943", "HTA9_1_20944", "HTA9_1_20945", "HTA9_1_20946", "HTA9_1_20947", "HTA9_1_20948", "HTA9_1_20949", "HTA9_1_20950", "HTA9_1_20951", "HTA9_1_20952", "HTA9_1_20953", "HTA9_1_20954", "HTA9_1_20955", "HTA9_1_20956", "HTA9_1_20957", "HTA9_1_20958", "HTA9_1_20959", "HTA9_1_20960", "HTA9_1_20961", "HTA9_1_20962", "HTA9_1_20963", "HTA9_1_20964", "HTA9_1_20965", "HTA9_1_20966", "HTA9_1_20967", "HTA9_1_20968", "HTA9_1_20969", "HTA9_1_20970", "HTA9_1_20971", "HTA9_1_20972", "HTA9_1_20973", "HTA9_1_20974", "HTA9_1_20975", "HTA9_1_20976", "HTA9_1_20977", "HTA9_1_20978", "HTA9_1_20979", "HTA9_1_20980", "HTA9_1_20981", "HTA9_1_20982", "HTA9_1_20983", "HTA9_1_20984", "HTA9_1_20985", "HTA9_1_20986", "HTA9_1_20987", "HTA9_1_20988", "HTA9_1_20989", "HTA9_1_20990", "HTA9_1_20991", "HTA9_1_20992", "HTA9_1_20993", "HTA9_1_20994", "HTA9_1_20995", "HTA9_1_20996", "HTA9_1_20997", "HTA9_1_20998", "HTA9_1_20999", "HTA9_1_21000", "HTA9_1_21001", "HTA9_1_21002", "HTA9_1_21003", "HTA9_1_21004", "HTA9_1_21005", "HTA9_1_21006", "HTA9_1_21007", "HTA9_1_21008", "HTA9_1_21009", "HTA9_1_21010", "HTA9_1_21011", "HTA9_1_21012", "HTA9_1_21013", "HTA9_1_21014", "HTA9_1_21015", "HTA9_1_21016", "HTA9_1_21017", "HTA9_1_21018", "HTA9_1_21019", "HTA9_1_21020", "HTA9_1_21021", "HTA9_1_21022", "HTA9_1_21023", "HTA9_1_21024", "HTA9_1_21025", "HTA9_1_21026", "HTA9_1_21027", "HTA9_1_21028", "HTA9_1_21029", "HTA9_1_21030", "HTA9_1_21031", "HTA9_1_21032", "HTA9_1_21033", "HTA9_1_21034", "HTA9_1_21035", "HTA9_1_21036", "HTA9_1_21037", "HTA9_1_21038", "HTA9_1_21039", "HTA9_1_21040", "HTA9_1_21041", "HTA9_1_21042", "HTA9_1_21043", "HTA9_1_21044", "HTA9_1_21045", "HTA9_1_21046", "HTA9_1_21047", "HTA9_1_21048", "HTA9_1_21049", "HTA9_1_21050", "HTA9_1_21051", "HTA9_1_21052", "HTA9_1_21053", "HTA9_1_21054", "HTA9_1_21055", "HTA9_1_21056", "HTA9_1_21057", "HTA9_1_21058", "HTA9_1_21059", "HTA9_1_21060", "HTA9_1_21061", "HTA9_1_21062", "HTA9_1_21063", "HTA9_1_21064", "HTA9_1_21065", "HTA9_1_21066", "HTA9_1_21067", "HTA9_1_21068", "HTA9_1_21069", "HTA9_1_21070", "HTA9_1_21071", "HTA9_1_21072", "HTA9_1_21073", "HTA9_1_21074", "HTA9_1_21075", "HTA9_1_21076", "HTA9_1_21077", "HTA9_1_21078", "HTA9_1_21079", "HTA9_1_21080", "HTA9_1_21081", "HTA9_1_21082", "HTA9_1_21083", "HTA9_1_21084", "HTA9_1_21085", "HTA9_1_21086", "HTA9_1_21087", "HTA9_1_21088", "HTA9_1_21089", "HTA9_1_21090", "HTA9_1_21091", "HTA9_1_21092", "HTA9_1_21093", "HTA9_1_21094", "HTA9_1_21095", "HTA9_1_21096", "HTA9_1_21097", "HTA9_1_21098", "HTA9_1_21099", "HTA9_1_21100", "HTA9_1_21101", 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"HTA9_1_21908", "HTA9_1_21909", "HTA9_1_21910", "HTA9_1_21911", "HTA9_1_21912", "HTA9_1_21913", "HTA9_1_21914", "HTA9_1_21915", "HTA9_1_21916", "HTA9_1_21917", "HTA9_1_21918", "HTA9_1_21919", "HTA9_1_21920", "HTA9_1_21921", "HTA9_1_21922", "HTA9_1_21923", "HTA9_1_21924", "HTA9_1_21925", "HTA9_1_21926", "HTA9_1_21927", "HTA9_1_21928", "HTA9_1_21929", "HTA9_1_21930", "HTA9_1_21931", "HTA9_1_21932", "HTA9_1_21933", "HTA9_1_21934", "HTA9_1_21935", "HTA9_1_21936", "HTA9_1_21937", "HTA9_1_21938", "HTA9_1_21939", "HTA9_1_21940", "HTA9_1_21941", "HTA9_1_21942", "HTA9_1_21943", "HTA9_1_21944", "HTA9_1_21945", "HTA9_1_21946", "HTA9_1_21947", "HTA9_1_21948", "HTA9_1_21949", "HTA9_1_21950", "HTA9_1_21951", "HTA9_1_21952", "HTA9_1_21953", "HTA9_1_21954", "HTA9_1_21955", "HTA9_1_21956", "HTA9_1_21957", "HTA9_1_21958", "HTA9_1_21959", "HTA9_1_21960", "HTA9_1_21961", "HTA9_1_21962", "HTA9_1_21963", "HTA9_1_21964", "HTA9_1_21965", "HTA9_1_21966", "HTA9_1_21967", "HTA9_1_21968", "HTA9_1_21969", "HTA9_1_21970", "HTA9_1_21971", "HTA9_1_21972", "HTA9_1_21973", "HTA9_1_21974", "HTA9_1_21975", "HTA9_1_21976", "HTA9_1_21977", "HTA9_1_21978", "HTA9_1_21979", "HTA9_1_21980", "HTA9_1_21981", "HTA9_1_21982", "HTA9_1_21983", "HTA9_1_21984", "HTA9_1_21985", "HTA9_1_21986", "HTA9_1_21987", "HTA9_1_21988", "HTA9_1_21989", "HTA9_1_21990", "HTA9_1_21991", "HTA9_1_21992", "HTA9_1_21993", "HTA9_1_21994", "HTA9_1_21995", "HTA9_1_21996", "HTA9_1_21997", "HTA9_1_21998", "HTA9_1_21999", "HTA9_1_22000", "HTA9_1_22001", "HTA9_1_22002", "HTA9_1_22003", "HTA9_1_22004", "HTA9_1_22005", "HTA9_1_22006", "HTA9_1_22007", "HTA9_1_22008", "HTA9_1_22009", "HTA9_1_22010", "HTA9_1_22011", "HTA9_1_22012", "HTA9_1_22013", "HTA9_1_22014", "HTA9_1_22015", "HTA9_1_22016", "HTA9_1_22017", "HTA9_1_22018", "HTA9_1_22019", "HTA9_1_22020", "HTA9_1_22021", "HTA9_1_22022", "HTA9_1_22023", "HTA9_1_22024", "HTA9_1_22025", "HTA9_1_22026", "HTA9_1_22027", "HTA9_1_22028", "HTA9_1_22029", "HTA9_1_22030", "HTA9_1_22031", 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"HTA9_1_22156", "HTA9_1_22157", "HTA9_1_22158", "HTA9_1_22159", "HTA9_1_22160", "HTA9_1_22161", "HTA9_1_22162", "HTA9_1_22163", "HTA9_1_22164", "HTA9_1_22165", "HTA9_1_22166", "HTA9_1_22167", "HTA9_1_22168", "HTA9_1_22169", "HTA9_1_22170", "HTA9_1_22171", "HTA9_1_22172", "HTA9_1_22173", "HTA9_1_22174", "HTA9_1_22175", "HTA9_1_22176", "HTA9_1_22177", "HTA9_1_22178", "HTA9_1_22179", "HTA9_1_22180", "HTA9_1_22181", "HTA9_1_22182", "HTA9_1_22183", "HTA9_1_22184", "HTA9_1_22185", "HTA9_1_22186", "HTA9_1_22187", "HTA9_1_22188", "HTA9_1_22189", "HTA9_1_22190", "HTA9_1_22191", "HTA9_1_22192", "HTA9_1_22193", "HTA9_1_22194", "HTA9_1_22195", "HTA9_1_22196", "HTA9_1_22197", "HTA9_1_22198", "HTA9_1_22199", "HTA9_1_22200", "HTA9_1_22201", "HTA9_1_22202", "HTA9_1_22203", "HTA9_1_22204", "HTA9_1_22205", "HTA9_1_22206", "HTA9_1_22207", "HTA9_1_22208", "HTA9_1_22209", "HTA9_1_22210", "HTA9_1_22211", "HTA9_1_22212", "HTA9_1_22213", "HTA9_1_22214", "HTA9_1_22215", "HTA9_1_22216", "HTA9_1_22217", "HTA9_1_22218", "HTA9_1_22219", "HTA9_1_22220", "HTA9_1_22221", "HTA9_1_22222", "HTA9_1_22223", "HTA9_1_22224", "HTA9_1_22225", "HTA9_1_22226", "HTA9_1_22227", "HTA9_1_22228", "HTA9_1_22229", "HTA9_1_22230", "HTA9_1_22231", "HTA9_1_22232", "HTA9_1_22233", "HTA9_1_22234", "HTA9_1_22235", "HTA9_1_22236", "HTA9_1_22237", "HTA9_1_22238", "HTA9_1_22239", "HTA9_1_22240", "HTA9_1_22241", "HTA9_1_22242", "HTA9_1_22243", "HTA9_1_22244", "HTA9_1_22245", "HTA9_1_22246", "HTA9_1_22247", "HTA9_1_22248", "HTA9_1_22249", "HTA9_1_22250", "HTA9_1_22251", "HTA9_1_22252", "HTA9_1_22253", "HTA9_1_22254", "HTA9_1_22255", "HTA9_1_22256", "HTA9_1_22257", "HTA9_1_22258", "HTA9_1_22259", "HTA9_1_22260", "HTA9_1_22261", "HTA9_1_22262", "HTA9_1_22263", "HTA9_1_22264", "HTA9_1_22265", "HTA9_1_22266", "HTA9_1_22267", "HTA9_1_22268", "HTA9_1_22269", "HTA9_1_22270", "HTA9_1_22271", "HTA9_1_22272", "HTA9_1_22273", "HTA9_1_22274", "HTA9_1_22275", "HTA9_1_22276", "HTA9_1_22277", "HTA9_1_22278", "HTA9_1_22279", "HTA9_1_22280", "HTA9_1_22281", "HTA9_1_22282", "HTA9_1_22283", "HTA9_1_22284", "HTA9_1_22285", "HTA9_1_22286", "HTA9_1_22287", "HTA9_1_22288", "HTA9_1_22289", "HTA9_1_22290", "HTA9_1_22291", "HTA9_1_22292", "HTA9_1_22293", "HTA9_1_22294", "HTA9_1_22295", "HTA9_1_22296", "HTA9_1_22297", "HTA9_1_22298", "HTA9_1_22299", "HTA9_1_22300", "HTA9_1_22301", "HTA9_1_22302", "HTA9_1_22303", "HTA9_1_22304", "HTA9_1_22305", "HTA9_1_22306", "HTA9_1_22307", "HTA9_1_22308", "HTA9_1_22309", "HTA9_1_22310", "HTA9_1_22311", "HTA9_1_22312", "HTA9_1_22313", "HTA9_1_22314", "HTA9_1_22315", "HTA9_1_22316", "HTA9_1_22317", "HTA9_1_22318", "HTA9_1_22319", "HTA9_1_22320", "HTA9_1_22321", "HTA9_1_22322", "HTA9_1_22323", "HTA9_1_22324", "HTA9_1_22325", "HTA9_1_22326", "HTA9_1_22327", "HTA9_1_22328", "HTA9_1_22329", "HTA9_1_22330", "HTA9_1_22331", "HTA9_1_22332", "HTA9_1_22333", "HTA9_1_22334", "HTA9_1_22335", "HTA9_1_22336", "HTA9_1_22337", "HTA9_1_22338", "HTA9_1_22339", "HTA9_1_22340", "HTA9_1_22341", "HTA9_1_22342", "HTA9_1_22343", "HTA9_1_22344", "HTA9_1_22345", "HTA9_1_22346", "HTA9_1_22347", "HTA9_1_22348", "HTA9_1_22349", "HTA9_1_22350", "HTA9_1_22351", "HTA9_1_22352", "HTA9_1_22353", "HTA9_1_22354", "HTA9_1_22355", "HTA9_1_22356", "HTA9_1_22357", "HTA9_1_22358", "HTA9_1_22359", "HTA9_1_22360", "HTA9_1_22361", "HTA9_1_22362", "HTA9_1_22363", "HTA9_1_22364", "HTA9_1_22365", "HTA9_1_22366", "HTA9_1_22367", "HTA9_1_22368", "HTA9_1_22369", "HTA9_1_22370", "HTA9_1_22371", "HTA9_1_22372", "HTA9_1_22373", "HTA9_1_22374", "HTA9_1_22375", "HTA9_1_22376", "HTA9_1_22377", "HTA9_1_22378", "HTA9_1_22379", "HTA9_1_22380", "HTA9_1_22381", "HTA9_1_22382", "HTA9_1_22383", "HTA9_1_22384", "HTA9_1_22385", "HTA9_1_22386", "HTA9_1_22387", "HTA9_1_22388", "HTA9_1_22389", "HTA9_1_22390", "HTA9_1_22391", "HTA9_1_22392", "HTA9_1_22393", "HTA9_1_22394", "HTA9_1_22395", "HTA9_1_22396", "HTA9_1_22397", "HTA9_1_22398", "HTA9_1_22399", "HTA9_1_22400", "HTA9_1_22401", "HTA9_1_22402", "HTA9_1_22403", "HTA9_1_22404", "HTA9_1_22405", "HTA9_1_22406", "HTA9_1_22407", "HTA9_1_22408", "HTA9_1_22409", "HTA9_1_22410", "HTA9_1_22411", "HTA9_1_22412", "HTA9_1_22413", "HTA9_1_22414", "HTA9_1_22415", "HTA9_1_22416", "HTA9_1_22417", "HTA9_1_22418", "HTA9_1_22419", "HTA9_1_22420", "HTA9_1_22421", "HTA9_1_22422", "HTA9_1_22423", "HTA9_1_22424", "HTA9_1_22425", "HTA9_1_22426", "HTA9_1_22427", "HTA9_1_22428", "HTA9_1_22429", "HTA9_1_22430", "HTA9_1_22431", "HTA9_1_22432", "HTA9_1_22433", "HTA9_1_22434", "HTA9_1_22435", "HTA9_1_22436", "HTA9_1_22437", "HTA9_1_22438", "HTA9_1_22439", "HTA9_1_22440", "HTA9_1_22441", "HTA9_1_22442", "HTA9_1_22443", "HTA9_1_22444", "HTA9_1_22445", "HTA9_1_22446", "HTA9_1_22447", "HTA9_1_22448", "HTA9_1_22449", "HTA9_1_22450", "HTA9_1_22451", "HTA9_1_22452", "HTA9_1_22453", "HTA9_1_22454", "HTA9_1_22455", "HTA9_1_22456", "HTA9_1_22457", "HTA9_1_22458", "HTA9_1_22459", "HTA9_1_22460", "HTA9_1_22461", "HTA9_1_22462", "HTA9_1_22463", "HTA9_1_22464", "HTA9_1_22465", "HTA9_1_22466", "HTA9_1_22467", "HTA9_1_22468", "HTA9_1_22469", "HTA9_1_22470", "HTA9_1_22471", "HTA9_1_22472", "HTA9_1_22473", "HTA9_1_22474", "HTA9_1_22475", "HTA9_1_22476", "HTA9_1_22477", "HTA9_1_22478", "HTA9_1_22479", "HTA9_1_22480", "HTA9_1_22481", "HTA9_1_22482", "HTA9_1_22483", "HTA9_1_22484", "HTA9_1_22485", "HTA9_1_22486", "HTA9_1_22487", "HTA9_1_22488", "HTA9_1_22489", "HTA9_1_22490", "HTA9_1_22491", "HTA9_1_22492", "HTA9_1_22493", "HTA9_1_22494", "HTA9_1_22495", "HTA9_1_22496", "HTA9_1_22497", "HTA9_1_22498", "HTA9_1_22499", "HTA9_1_22500", "HTA9_1_22501", "HTA9_1_22502", "HTA9_1_22503", "HTA9_1_22504", "HTA9_1_22505", "HTA9_1_22506", "HTA9_1_22507", "HTA9_1_22508", "HTA9_1_22509", "HTA9_1_22510", "HTA9_1_22511", "HTA9_1_22512", "HTA9_1_22513", "HTA9_1_22514", "HTA9_1_22515", "HTA9_1_22516", "HTA9_1_22517", "HTA9_1_22518", "HTA9_1_22519", "HTA9_1_22520", "HTA9_1_22521", "HTA9_1_22522", "HTA9_1_22523", "HTA9_1_22524", "HTA9_1_22525", "HTA9_1_22526", "HTA9_1_22527", "HTA9_1_22528", "HTA9_1_22529", "HTA9_1_22530", "HTA9_1_22531", "HTA9_1_22532", "HTA9_1_22533", "HTA9_1_22534", "HTA9_1_22535", "HTA9_1_22536", "HTA9_1_22537", "HTA9_1_22538", "HTA9_1_22539", "HTA9_1_22540", "HTA9_1_22541", "HTA9_1_22542", "HTA9_1_22543", "HTA9_1_22544", "HTA9_1_22545", "HTA9_1_22546", "HTA9_1_22547", "HTA9_1_22548", "HTA9_1_22549", "HTA9_1_22550", "HTA9_1_22551", "HTA9_1_22552", "HTA9_1_22553", "HTA9_1_22554", "HTA9_1_22555", "HTA9_1_22556", "HTA9_1_22557", "HTA9_1_22558", "HTA9_1_22559", "HTA9_1_22560", "HTA9_1_22561", "HTA9_1_22562", "HTA9_1_22563", "HTA9_1_22564", "HTA9_1_22565", "HTA9_1_22566", "HTA9_1_22567", "HTA9_1_22568", "HTA9_1_22569", "HTA9_1_22570", "HTA9_1_22571", "HTA9_1_22572", "HTA9_1_22573", "HTA9_1_22574", "HTA9_1_22575", "HTA9_1_22576", "HTA9_1_22577", "HTA9_1_22578", "HTA9_1_22579", "HTA9_1_22580", "HTA9_1_22581", "HTA9_1_22582", "HTA9_1_22583", "HTA9_1_22584", "HTA9_1_22585", "HTA9_1_22586", "HTA9_1_22587", "HTA9_1_22588", "HTA9_1_22589", "HTA9_1_22590", "HTA9_1_22591", "HTA9_1_22592", "HTA9_1_22593", "HTA9_1_22594", "HTA9_1_22595", "HTA9_1_22596", "HTA9_1_22597", "HTA9_1_22598", "HTA9_1_22599", "HTA9_1_22600", "HTA9_1_22601", "HTA9_1_22602", "HTA9_1_22603", "HTA9_1_22604", "HTA9_1_22605", "HTA9_1_22606", "HTA9_1_22607", "HTA9_1_22608", "HTA9_1_22609", "HTA9_1_22610", "HTA9_1_22611", "HTA9_1_22612", "HTA9_1_22613", "HTA9_1_22614", "HTA9_1_22615", "HTA9_1_22616", "HTA9_1_22617", "HTA9_1_22618", "HTA9_1_22619", "HTA9_1_22620", "HTA9_1_22621", "HTA9_1_22622", "HTA9_1_22623", "HTA9_1_22624", "HTA9_1_22625", "HTA9_1_22626", "HTA9_1_22627", "HTA9_1_22628", "HTA9_1_22629", "HTA9_1_22630", "HTA9_1_22631", "HTA9_1_22632", "HTA9_1_22633", "HTA9_1_22634", "HTA9_1_22635", "HTA9_1_22636", "HTA9_1_22637", "HTA9_1_22638", "HTA9_1_22639", "HTA9_1_22640", "HTA9_1_22641", "HTA9_1_22642", "HTA9_1_22643", "HTA9_1_22644", "HTA9_1_22645", "HTA9_1_22646", "HTA9_1_22647", "HTA9_1_22648", "HTA9_1_22649", "HTA9_1_22650", "HTA9_1_22651", "HTA9_1_22652", "HTA9_1_22653", "HTA9_1_22654", "HTA9_1_22655", "HTA9_1_22656", "HTA9_1_22657", "HTA9_1_22658", "HTA9_1_22659", "HTA9_1_22660", "HTA9_1_22661", "HTA9_1_22662", "HTA9_1_22663", "HTA9_1_22664", "HTA9_1_22665", "HTA9_1_22666", "HTA9_1_22667", "HTA9_1_22668", "HTA9_1_22669", "HTA9_1_22670", "HTA9_1_22671", "HTA9_1_22672", "HTA9_1_22673", "HTA9_1_22674", "HTA9_1_22675", "HTA9_1_22676", "HTA9_1_22677", "HTA9_1_22678", "HTA9_1_22679", "HTA9_1_22680", "HTA9_1_22681", "HTA9_1_22682", "HTA9_1_22683", "HTA9_1_22684", "HTA9_1_22685", "HTA9_1_22686", "HTA9_1_22687", "HTA9_1_22688", "HTA9_1_22689", "HTA9_1_22690", "HTA9_1_22691", "HTA9_1_22692", "HTA9_1_22693", "HTA9_1_22694", "HTA9_1_22695", "HTA9_1_22696", "HTA9_1_22697", "HTA9_1_22698", "HTA9_1_22699", "HTA9_1_22700", "HTA9_1_22701", "HTA9_1_22702", "HTA9_1_22703", "HTA9_1_22704", "HTA9_1_22705", "HTA9_1_22706", "HTA9_1_22707", "HTA9_1_22708", "HTA9_1_22709", "HTA9_1_22710", "HTA9_1_22711", "HTA9_1_22712", "HTA9_1_22713", "HTA9_1_22714", "HTA9_1_22715", "HTA9_1_22716", "HTA9_1_22717", "HTA9_1_22718", "HTA9_1_22719", "HTA9_1_22720", "HTA9_1_22721", "HTA9_1_22722", "HTA9_1_22723", "HTA9_1_22724", "HTA9_1_22725", "HTA9_1_22726", "HTA9_1_22727", "HTA9_1_22728", "HTA9_1_22729", "HTA9_1_22730", "HTA9_1_22731", "HTA9_1_22732", "HTA9_1_22733", "HTA9_1_22734", "HTA9_1_22735", "HTA9_1_22736", "HTA9_1_22737", "HTA9_1_22738", "HTA9_1_22739", "HTA9_1_22740", "HTA9_1_22741", "HTA9_1_22742", "HTA9_1_22743", "HTA9_1_22744", "HTA9_1_22745", "HTA9_1_22746", "HTA9_1_22747", "HTA9_1_22748", "HTA9_1_22749", "HTA9_1_22750", "HTA9_1_22751", "HTA9_1_22752", "HTA9_1_22753", "HTA9_1_22754", "HTA9_1_22755", "HTA9_1_22756", "HTA9_1_22757", "HTA9_1_22758", "HTA9_1_22759", "HTA9_1_22760", "HTA9_1_22761", "HTA9_1_22762", "HTA9_1_22763", "HTA9_1_22764", "HTA9_1_22765", "HTA9_1_22766", "HTA9_1_22767", "HTA9_1_22768", "HTA9_1_22769", "HTA9_1_22770", "HTA9_1_22771", "HTA9_1_22772", "HTA9_1_22773", "HTA9_1_22774", "HTA9_1_22775", "HTA9_1_22776", "HTA9_1_22777", "HTA9_1_22778", "HTA9_1_22779", "HTA9_1_22780", "HTA9_1_22781", "HTA9_1_22782", "HTA9_1_22783", "HTA9_1_22784", "HTA9_1_22785", "HTA9_1_22786", "HTA9_1_22787", "HTA9_1_22788", "HTA9_1_22789", "HTA9_1_22790", "HTA9_1_22791", "HTA9_1_22792", "HTA9_1_22793", "HTA9_1_22794", "HTA9_1_22795", "HTA9_1_22796", "HTA9_1_22797", "HTA9_1_22798", "HTA9_1_22799", "HTA9_1_22800", "HTA9_1_22801", "HTA9_1_22802", "HTA9_1_22803", "HTA9_1_22804", "HTA9_1_22805", "HTA9_1_22806", "HTA9_1_22807", "HTA9_1_22808", "HTA9_1_22809", "HTA9_1_22810", "HTA9_1_22811", "HTA9_1_22812", "HTA9_1_22813", "HTA9_1_22814", "HTA9_1_22815", "HTA9_1_22816", "HTA9_1_22817", "HTA9_1_22818", "HTA9_1_22819", "HTA9_1_22820", "HTA9_1_22821", "HTA9_1_22822", "HTA9_1_22823", "HTA9_1_22824", "HTA9_1_22825", "HTA9_1_22826", "HTA9_1_22827", "HTA9_1_22828", "HTA9_1_22829", "HTA9_1_22830", "HTA9_1_22831", "HTA9_1_22832", "HTA9_1_22833", "HTA9_1_22834", "HTA9_1_22835", "HTA9_1_22836", "HTA9_1_22837", "HTA9_1_22838", "HTA9_1_22839", "HTA9_1_22840", "HTA9_1_22841", "HTA9_1_22842", "HTA9_1_22843", "HTA9_1_22844", "HTA9_1_22845", "HTA9_1_22846", "HTA9_1_22847", "HTA9_1_22848", "HTA9_1_22849", "HTA9_1_22850", "HTA9_1_22851", "HTA9_1_22852", "HTA9_1_22853", "HTA9_1_22854", "HTA9_1_22855", "HTA9_1_22856", "HTA9_1_22857", "HTA9_1_22858", "HTA9_1_22859", "HTA9_1_22860", "HTA9_1_22861", "HTA9_1_22862", "HTA9_1_22863", "HTA9_1_22864", "HTA9_1_22865", "HTA9_1_22866", "HTA9_1_22867", "HTA9_1_22868", "HTA9_1_22869", "HTA9_1_22870", "HTA9_1_22871", "HTA9_1_22872", "HTA9_1_22873", "HTA9_1_22874", "HTA9_1_22875", "HTA9_1_22876", "HTA9_1_22877", "HTA9_1_22878", "HTA9_1_22879", "HTA9_1_22880", "HTA9_1_22881", "HTA9_1_22882", "HTA9_1_22883", "HTA9_1_22884", "HTA9_1_22885", "HTA9_1_22886", "HTA9_1_22887", "HTA9_1_22888", "HTA9_1_22889", "HTA9_1_22890", "HTA9_1_22891", "HTA9_1_22892", "HTA9_1_22893", "HTA9_1_22894", "HTA9_1_22895", "HTA9_1_22896", "HTA9_1_22897", "HTA9_1_22898", "HTA9_1_22899", "HTA9_1_22900", "HTA9_1_22901", "HTA9_1_22902", "HTA9_1_22903", "HTA9_1_22904", "HTA9_1_22905", "HTA9_1_22906", "HTA9_1_22907", "HTA9_1_22908", "HTA9_1_22909", "HTA9_1_22910", "HTA9_1_22911", "HTA9_1_22912", "HTA9_1_22913", "HTA9_1_22914", "HTA9_1_22915", "HTA9_1_22916", "HTA9_1_22917", "HTA9_1_22918", "HTA9_1_22919", "HTA9_1_22920", "HTA9_1_22921", "HTA9_1_22922", "HTA9_1_22923", "HTA9_1_22924", "HTA9_1_22925", "HTA9_1_22926", "HTA9_1_22927", "HTA9_1_22928", "HTA9_1_22929", "HTA9_1_22930", "HTA9_1_22931", "HTA9_1_22932", "HTA9_1_22933", "HTA9_1_22934", "HTA9_1_22935", "HTA9_1_22936", "HTA9_1_22937", "HTA9_1_22938", "HTA9_1_22939", "HTA9_1_22940", "HTA9_1_22941", "HTA9_1_22942", "HTA9_1_22943", "HTA9_1_22944", "HTA9_1_22945", "HTA9_1_22946", "HTA9_1_22947", "HTA9_1_22948", "HTA9_1_22949", "HTA9_1_22950", "HTA9_1_22951", "HTA9_1_22952", "HTA9_1_22953", "HTA9_1_22954", "HTA9_1_22955", "HTA9_1_22956", "HTA9_1_22957", "HTA9_1_22958", "HTA9_1_22959", "HTA9_1_22960", "HTA9_1_22961", "HTA9_1_22962", "HTA9_1_22963", "HTA9_1_22964", "HTA9_1_22965", "HTA9_1_22966", "HTA9_1_22967", "HTA9_1_22968", "HTA9_1_22969", "HTA9_1_22970", "HTA9_1_22971", "HTA9_1_22972", "HTA9_1_22973", "HTA9_1_22974", "HTA9_1_22975", "HTA9_1_22976", "HTA9_1_22977", "HTA9_1_22978", "HTA9_1_22979", "HTA9_1_22980", "HTA9_1_22981", "HTA9_1_22982", "HTA9_1_22983", "HTA9_1_22984", "HTA9_1_22985", "HTA9_1_22986", "HTA9_1_22987", "HTA9_1_22988", "HTA9_1_22989", "HTA9_1_22990", "HTA9_1_22991", "HTA9_1_22992", "HTA9_1_22993", "HTA9_1_22994", "HTA9_1_22995", "HTA9_1_22996", "HTA9_1_22997", "HTA9_1_22998", "HTA9_1_22999", "HTA9_1_23000", "HTA9_1_23001", "HTA9_1_23002", "HTA9_1_23003", "HTA9_1_23004", "HTA9_1_23005", "HTA9_1_23006", "HTA9_1_23007", "HTA9_1_23008", "HTA9_1_23009", "HTA9_1_23010", "HTA9_1_23011", "HTA9_1_23012", "HTA9_1_23013", "HTA9_1_23014", "HTA9_1_23015", "HTA9_1_23016", "HTA9_1_23017", "HTA9_1_23018", "HTA9_1_23019", "HTA9_1_23020", "HTA9_1_23021", "HTA9_1_23022", "HTA9_1_23023", "HTA9_1_23024", "HTA9_1_23025", "HTA9_1_23026", "HTA9_1_23027", "HTA9_1_23028", "HTA9_1_23029", "HTA9_1_23030", "HTA9_1_23031", "HTA9_1_23032", "HTA9_1_23033", "HTA9_1_23034", "HTA9_1_23035", "HTA9_1_23036", "HTA9_1_23037", "HTA9_1_23038", "HTA9_1_23039", "HTA9_1_23040", "HTA9_1_23041", "HTA9_1_23042", "HTA9_1_23043", "HTA9_1_23044", "HTA9_1_23045", "HTA9_1_23046", "HTA9_1_23047", "HTA9_1_23048", "HTA9_1_23049", "HTA9_1_23050", "HTA9_1_23051", "HTA9_1_23052", "HTA9_1_23053", "HTA9_1_23054", "HTA9_1_23055", "HTA9_1_23056", "HTA9_1_23057", "HTA9_1_23058", "HTA9_1_23059", "HTA9_1_23060", "HTA9_1_23061", "HTA9_1_23062", "HTA9_1_23063", "HTA9_1_23064", "HTA9_1_23065", "HTA9_1_23066", "HTA9_1_23067", "HTA9_1_23068", "HTA9_1_23069", "HTA9_1_23070", "HTA9_1_23071", "HTA9_1_23072", "HTA9_1_23073", "HTA9_1_23074", "HTA9_1_23075", "HTA9_1_23076", "HTA9_1_23077", "HTA9_1_23078", "HTA9_1_23079", "HTA9_1_23080", "HTA9_1_23081", "HTA9_1_23082", "HTA9_1_23083", "HTA9_1_23084", "HTA9_1_23085", "HTA9_1_23086", "HTA9_1_23087", "HTA9_1_23088", "HTA9_1_23089", "HTA9_1_23090", "HTA9_1_23091", "HTA9_1_23092", "HTA9_1_23093", "HTA9_1_23094", "HTA9_1_23095", "HTA9_1_23096", "HTA9_1_23097", "HTA9_1_23098", "HTA9_1_23099", "HTA9_1_23100", "HTA9_1_23101", "HTA9_1_23102", "HTA9_1_23103", "HTA9_1_23104", "HTA9_1_23105", "HTA9_1_23106", "HTA9_1_23107", "HTA9_1_23108", "HTA9_1_23109", "HTA9_1_23110", "HTA9_1_23111", "HTA9_1_23112", "HTA9_1_23113", "HTA9_1_23114", "HTA9_1_23115", "HTA9_1_23116", "HTA9_1_23117", "HTA9_1_23118", "HTA9_1_23119", "HTA9_1_23120", "HTA9_1_23121", "HTA9_1_23122", "HTA9_1_23123", "HTA9_1_23124", "HTA9_1_23125", "HTA9_1_23126", "HTA9_1_23127", "HTA9_1_23128", "HTA9_1_23129", "HTA9_1_23130", "HTA9_1_23131", "HTA9_1_23132", "HTA9_1_23133", "HTA9_1_23134", "HTA9_1_23135", "HTA9_1_23136", "HTA9_1_23137", "HTA9_1_23138", "HTA9_1_23139", "HTA9_1_23140", "HTA9_1_23141", "HTA9_1_23142", "HTA9_1_23143", "HTA9_1_23144", "HTA9_1_23145", "HTA9_1_23146", "HTA9_1_23147", "HTA9_1_23148", "HTA9_1_23149", "HTA9_1_23150", "HTA9_1_23151", "HTA9_1_23152", "HTA9_1_23153", "HTA9_1_23154", "HTA9_1_23155", "HTA9_1_23156", "HTA9_1_23157", "HTA9_1_23158", "HTA9_1_23159", "HTA9_1_23160", "HTA9_1_23161", "HTA9_1_23162", "HTA9_1_23163", "HTA9_1_23164", "HTA9_1_23165", "HTA9_1_23166", "HTA9_1_23167", "HTA9_1_23168", "HTA9_1_23169", "HTA9_1_23170", "HTA9_1_23171", "HTA9_1_23172", "HTA9_1_23173", "HTA9_1_23174", "HTA9_1_23175", "HTA9_1_23176", "HTA9_1_23177", "HTA9_1_23178", "HTA9_1_23179", "HTA9_1_23180", "HTA9_1_23181", "HTA9_1_23182", "HTA9_1_23183", "HTA9_1_23184", "HTA9_1_23185", "HTA9_1_23186", "HTA9_1_23187", "HTA9_1_23188", "HTA9_1_23189", "HTA9_1_23190", "HTA9_1_23191", "HTA9_1_23192", "HTA9_1_23193", "HTA9_1_23194", "HTA9_1_23195", "HTA9_1_23196", "HTA9_1_23197", "HTA9_1_23198", "HTA9_1_23199", "HTA9_1_23200", "HTA9_1_23201", "HTA9_1_23202", "HTA9_1_23203", "HTA9_1_23204", "HTA9_1_23205", "HTA9_1_23206", "HTA9_1_23207", "HTA9_1_23208", "HTA9_1_23209", "HTA9_1_23210", "HTA9_1_23211", "HTA9_1_23212", "HTA9_1_23213", "HTA9_1_23214", "HTA9_1_23215", "HTA9_1_23216", "HTA9_1_23217", "HTA9_1_23218", "HTA9_1_23219", "HTA9_1_23220", "HTA9_1_23221", "HTA9_1_23222", "HTA9_1_23223", "HTA9_1_23224", "HTA9_1_23225", "HTA9_1_23226", "HTA9_1_23227", "HTA9_1_23228", "HTA9_1_23229", "HTA9_1_23230", "HTA9_1_23231", "HTA9_1_23232", "HTA9_1_23233", "HTA9_1_23234", "HTA9_1_23235", "HTA9_1_23236", "HTA9_1_23237", "HTA9_1_23238", "HTA9_1_23239", "HTA9_1_23240", "HTA9_1_23241", "HTA9_1_23242", "HTA9_1_23243", "HTA9_1_23244", "HTA9_1_23245", "HTA9_1_23246", "HTA9_1_23247", "HTA9_1_23248", "HTA9_1_23249", "HTA9_1_23250", "HTA9_1_23251", "HTA9_1_23252", "HTA9_1_23253", "HTA9_1_23254", "HTA9_1_23255", "HTA9_1_23256", "HTA9_1_23257", "HTA9_1_23258", "HTA9_1_23259", "HTA9_1_23260", "HTA9_1_23261", "HTA9_1_23262", "HTA9_1_23263", "HTA9_1_23264", "HTA9_1_23265", "HTA9_1_23266", "HTA9_1_23267", "HTA9_1_23268", "HTA9_1_23269", "HTA9_1_23270", "HTA9_1_23271", "HTA9_1_23272", "HTA9_1_23273", "HTA9_1_23274", "HTA9_1_23275", "HTA9_1_23276", "HTA9_1_23277", "HTA9_1_23278", "HTA9_1_23279", "HTA9_1_23280", "HTA9_1_23281", "HTA9_1_23282", "HTA9_1_23283", "HTA9_1_23284", "HTA9_1_23285", "HTA9_1_23286", "HTA9_1_23287", "HTA9_1_23288", "HTA9_1_23289", "HTA9_1_23290", "HTA9_1_23291", "HTA9_1_23292", "HTA9_1_23293", "HTA9_1_23294", "HTA9_1_23295", "HTA9_1_23296", "HTA9_1_23297", "HTA9_1_23298", "HTA9_1_23299", "HTA9_1_23300", "HTA9_1_23301", "HTA9_1_23302", "HTA9_1_23303", "HTA9_1_23304", "HTA9_1_23305", "HTA9_1_23306", "HTA9_1_23307", "HTA9_1_23308", "HTA9_1_23309", "HTA9_1_23310", "HTA9_1_23311", "HTA9_1_23312", "HTA9_1_23313", "HTA9_1_23314", "HTA9_1_23315", "HTA9_1_23316", "HTA9_1_23317", "HTA9_1_23318", "HTA9_1_23319", "HTA9_1_23320", "HTA9_1_23321", "HTA9_1_23322", "HTA9_1_23323", "HTA9_1_23324", "HTA9_1_23325", "HTA9_1_23326", "HTA9_1_23327", "HTA9_1_23328", "HTA9_1_23329", "HTA9_1_23330", "HTA9_1_23331", "HTA9_1_23332", "HTA9_1_23333", "HTA9_1_23334", "HTA9_1_23335", "HTA9_1_23336", "HTA9_1_23337", "HTA9_1_23338", "HTA9_1_23339", "HTA9_1_23340", "HTA9_1_23341", "HTA9_1_23342", "HTA9_1_23343", "HTA9_1_23344", "HTA9_1_23345", "HTA9_1_23346", "HTA9_1_23347", "HTA9_1_23348", "HTA9_1_23349", "HTA9_1_23350", "HTA9_1_23351", "HTA9_1_23352", "HTA9_1_23353", "HTA9_1_23354", "HTA9_1_23355", "HTA9_1_23356", "HTA9_1_23357", "HTA9_1_23358", "HTA9_1_23359", "HTA9_1_23360", "HTA9_1_23361", "HTA9_1_23362", "HTA9_1_23363", "HTA9_1_23364", "HTA9_1_23365", "HTA9_1_23366", "HTA9_1_23367", "HTA9_1_23368", "HTA9_1_23369", "HTA9_1_23370", "HTA9_1_23371", "HTA9_1_23372", "HTA9_1_23373", "HTA9_1_23374", "HTA9_1_23375", "HTA9_1_23376", "HTA9_1_23377", "HTA9_1_23378", "HTA9_1_23379", "HTA9_1_23380", "HTA9_1_23381", "HTA9_1_23382", "HTA9_1_23383", "HTA9_1_23384", "HTA9_1_23385", "HTA9_1_23386", "HTA9_1_23387", "HTA9_1_23388", "HTA9_1_23389", "HTA9_1_23390", "HTA9_1_23391", "HTA9_1_23392", "HTA9_1_23393", "HTA9_1_23394", "HTA9_1_23395", "HTA9_1_23396", "HTA9_1_23397", "HTA9_1_23398", "HTA9_1_23399", "HTA9_1_23400", "HTA9_1_23401", "HTA9_1_23402", "HTA9_1_23403", "HTA9_1_23404", "HTA9_1_23405", "HTA9_1_23406", "HTA9_1_23407", "HTA9_1_23408", "HTA9_1_23409", "HTA9_1_23410", "HTA9_1_23411", "HTA9_1_23412", "HTA9_1_23413", "HTA9_1_23414", "HTA9_1_23415", "HTA9_1_23416", "HTA9_1_23417", "HTA9_1_23418", "HTA9_1_23419", "HTA9_1_23420", "HTA9_1_23421", "HTA9_1_23422", "HTA9_1_23423", "HTA9_1_23424", "HTA9_1_23425", "HTA9_1_23426", "HTA9_1_23427", "HTA9_1_23428", "HTA9_1_23429", "HTA9_1_23430", "HTA9_1_23431", "HTA9_1_23432", "HTA9_1_23433", "HTA9_1_23434", "HTA9_1_23435", "HTA9_1_23436", "HTA9_1_23437", "HTA9_1_23438", "HTA9_1_23439", "HTA9_1_23440", "HTA9_1_23441", "HTA9_1_23442", "HTA9_1_23443", "HTA9_1_23444", "HTA9_1_23445", "HTA9_1_23446", "HTA9_1_23447", "HTA9_1_23448", "HTA9_1_23449", "HTA9_1_23450", "HTA9_1_23451", "HTA9_1_23452", "HTA9_1_23453", "HTA9_1_23454", "HTA9_1_23455", "HTA9_1_23456", "HTA9_1_23457", "HTA9_1_23458", "HTA9_1_23459", "HTA9_1_23460", "HTA9_1_23461", "HTA9_1_23462", "HTA9_1_23463", "HTA9_1_23464", "HTA9_1_23465", "HTA9_1_23466", "HTA9_1_23467", "HTA9_1_23468", "HTA9_1_23469", "HTA9_1_23470", "HTA9_1_23471", "HTA9_1_23472", "HTA9_1_23473", "HTA9_1_23474", "HTA9_1_23475", "HTA9_1_23476", "HTA9_1_23477", "HTA9_1_23478", "HTA9_1_23479", "HTA9_1_23480", "HTA9_1_23481", "HTA9_1_23482", "HTA9_1_23483", "HTA9_1_23484", "HTA9_1_23485", "HTA9_1_23486", "HTA9_1_23487", "HTA9_1_23488", "HTA9_1_23489", "HTA9_1_23490", "HTA9_1_23491", "HTA9_1_23492", "HTA9_1_23493", "HTA9_1_23494", "HTA9_1_23495", "HTA9_1_23496", "HTA9_1_23497", "HTA9_1_23498", "HTA9_1_23499", "HTA9_1_23500", "HTA9_1_23501", "HTA9_1_23502", "HTA9_1_23503", "HTA9_1_23504", "HTA9_1_23505", "HTA9_1_23506", "HTA9_1_23507", "HTA9_1_23508", "HTA9_1_23509", "HTA9_1_23510", "HTA9_1_23511", "HTA9_1_23512", "HTA9_1_23513", "HTA9_1_23514", "HTA9_1_23515", "HTA9_1_23516", "HTA9_1_23517", "HTA9_1_23518", "HTA9_1_23519", "HTA9_1_23520", "HTA9_1_23521", "HTA9_1_23522", "HTA9_1_23523", "HTA9_1_23524", "HTA9_1_23525", "HTA9_1_23526", "HTA9_1_23527", "HTA9_1_23528", "HTA9_1_23529", "HTA9_1_23530", "HTA9_1_23531", "HTA9_1_23532", "HTA9_1_23533", "HTA9_1_23534", "HTA9_1_23535", "HTA9_1_23536", "HTA9_1_23537", "HTA9_1_23538", "HTA9_1_23539", "HTA9_1_23540", "HTA9_1_23541", "HTA9_1_23542", "HTA9_1_23543", "HTA9_1_23544", "HTA9_1_23545", "HTA9_1_23546", "HTA9_1_23547", "HTA9_1_23548", "HTA9_1_23549", "HTA9_1_23550", "HTA9_1_23551", "HTA9_1_23552", "HTA9_1_23553", "HTA9_1_23554", "HTA9_1_23555", "HTA9_1_23556", "HTA9_1_23557", "HTA9_1_23558", "HTA9_1_23559", "HTA9_1_23560", "HTA9_1_23561", "HTA9_1_23562", "HTA9_1_23563", "HTA9_1_23564", "HTA9_1_23565", "HTA9_1_23566", "HTA9_1_23567", "HTA9_1_23568", "HTA9_1_23569", "HTA9_1_23570", "HTA9_1_23571", "HTA9_1_23572", "HTA9_1_23573", "HTA9_1_23574", "HTA9_1_23575", "HTA9_1_23576", "HTA9_1_23577", "HTA9_1_23578", "HTA9_1_23579", "HTA9_1_23580", "HTA9_1_23581", "HTA9_1_23582", "HTA9_1_23583", "HTA9_1_23584", "HTA9_1_23585", "HTA9_1_23586", "HTA9_1_23587", "HTA9_1_23588", "HTA9_1_23589", "HTA9_1_23590", "HTA9_1_23591", "HTA9_1_23592", "HTA9_1_23593", "HTA9_1_23594", "HTA9_1_23595", "HTA9_1_23596", "HTA9_1_23597", "HTA9_1_23598", "HTA9_1_23599", "HTA9_1_23600", "HTA9_1_23601", "HTA9_1_23602", "HTA9_1_23603", "HTA9_1_23604", "HTA9_1_23605", "HTA9_1_23606", "HTA9_1_23607", "HTA9_1_23608", "HTA9_1_23609", "HTA9_1_23610", "HTA9_1_23611", "HTA9_1_23612", "HTA9_1_23613", "HTA9_1_23614", "HTA9_1_23615", "HTA9_1_23616", "HTA9_1_23617", "HTA9_1_23618", "HTA9_1_23619", "HTA9_1_23620", "HTA9_1_23621", "HTA9_1_23622", "HTA9_1_23623", "HTA9_1_23624", "HTA9_1_23625", "HTA9_1_23626", "HTA9_1_23627", "HTA9_1_23628", "HTA9_1_23629", "HTA9_1_23630", "HTA9_1_23631", "HTA9_1_23632", "HTA9_1_23633", "HTA9_1_23634", "HTA9_1_23635", "HTA9_1_23636", "HTA9_1_23637", "HTA9_1_23638", "HTA9_1_23639", "HTA9_1_23640", "HTA9_1_23641", "HTA9_1_23642", "HTA9_1_23643", "HTA9_1_23644", "HTA9_1_23645", "HTA9_1_23646", "HTA9_1_23647", "HTA9_1_23648", "HTA9_1_23649", "HTA9_1_23650", "HTA9_1_23651", "HTA9_1_23652", "HTA9_1_23653", "HTA9_1_23654", "HTA9_1_23655", "HTA9_1_23656", "HTA9_1_23657", "HTA9_1_23658", "HTA9_1_23659", "HTA9_1_23660", "HTA9_1_23661", "HTA9_1_23662", "HTA9_1_23663", "HTA9_1_23664", "HTA9_1_23665", "HTA9_1_23666", "HTA9_1_23667", "HTA9_1_23668", "HTA9_1_23669", "HTA9_1_23670", "HTA9_1_23671", "HTA9_1_23672", "HTA9_1_23673", "HTA9_1_23674", "HTA9_1_23675", "HTA9_1_23676", "HTA9_1_23677", "HTA9_1_23678", "HTA9_1_23679", "HTA9_1_23680", "HTA9_1_23681", "HTA9_1_23682", "HTA9_1_23683", "HTA9_1_23684", "HTA9_1_23685", "HTA9_1_23686", "HTA9_1_23687", "HTA9_1_23688", "HTA9_1_23689", "HTA9_1_23690", "HTA9_1_23691", "HTA9_1_23692", "HTA9_1_23693", "HTA9_1_23694", "HTA9_1_23695", "HTA9_1_23696", "HTA9_1_23697", "HTA9_1_23698", "HTA9_1_23699", "HTA9_1_23700", "HTA9_1_23701", "HTA9_1_23702", "HTA9_1_23703", "HTA9_1_23704", "HTA9_1_23705", "HTA9_1_23706", "HTA9_1_23707", "HTA9_1_23708", "HTA9_1_23709", "HTA9_1_23710", "HTA9_1_23711", "HTA9_1_23712", "HTA9_1_23713", "HTA9_1_23714", "HTA9_1_23715", "HTA9_1_23716", "HTA9_1_23717", "HTA9_1_23718", "HTA9_1_23719", "HTA9_1_23720", "HTA9_1_23721", "HTA9_1_23722", "HTA9_1_23723", "HTA9_1_23724", "HTA9_1_23725", "HTA9_1_23726", "HTA9_1_23727", "HTA9_1_23728", "HTA9_1_23729", "HTA9_1_23730", "HTA9_1_23731", "HTA9_1_23732", "HTA9_1_23733", "HTA9_1_23734", "HTA9_1_23735", "HTA9_1_23736", "HTA9_1_23737", "HTA9_1_23738", "HTA9_1_23739", "HTA9_1_23740", "HTA9_1_23741", "HTA9_1_23742", "HTA9_1_23743", "HTA9_1_23744", "HTA9_1_23745", "HTA9_1_23746", "HTA9_1_23747", "HTA9_1_23748", "HTA9_1_23749", "HTA9_1_23750", "HTA9_1_23751", "HTA9_1_23752", "HTA9_1_23753", "HTA9_1_23754", "HTA9_1_23755", "HTA9_1_23756", "HTA9_1_23757", "HTA9_1_23758", "HTA9_1_23759", "HTA9_1_23760", "HTA9_1_23761", "HTA9_1_23762", "HTA9_1_23763", "HTA9_1_23764", "HTA9_1_23765", "HTA9_1_23766", "HTA9_1_23767", "HTA9_1_23768", "HTA9_1_23769", "HTA9_1_23770", "HTA9_1_23771", "HTA9_1_23772", "HTA9_1_23773", "HTA9_1_23774", "HTA9_1_23775", "HTA9_1_23776", "HTA9_1_23777", "HTA9_1_23778", "HTA9_1_23779", "HTA9_1_23780", "HTA9_1_23781", "HTA9_1_23782", "HTA9_1_23783", "HTA9_1_23784", "HTA9_1_23785", "HTA9_1_23786", "HTA9_1_23787", "HTA9_1_23788", "HTA9_1_23789", "HTA9_1_23790", "HTA9_1_23791", "HTA9_1_23792", "HTA9_1_23793", "HTA9_1_23794", "HTA9_1_23795", "HTA9_1_23796", "HTA9_1_23797", "HTA9_1_23798", "HTA9_1_23799", "HTA9_1_23800", "HTA9_1_23801", "HTA9_1_23802", "HTA9_1_23803", "HTA9_1_23804", "HTA9_1_23805", "HTA9_1_23806", "HTA9_1_23807", "HTA9_1_23808", "HTA9_1_23809", "HTA9_1_23810", "HTA9_1_23811", "HTA9_1_23812", "HTA9_1_23813", "HTA9_1_23814", "HTA9_1_23815", "HTA9_1_23816", "HTA9_1_23817", "HTA9_1_23818", "HTA9_1_23819", "HTA9_1_23820", "HTA9_1_23821", "HTA9_1_23822", "HTA9_1_23823", "HTA9_1_23824", "HTA9_1_23825", "HTA9_1_23826", "HTA9_1_23827", "HTA9_1_23828", "HTA9_1_23829", "HTA9_1_23830", "HTA9_1_23831", "HTA9_1_23832", "HTA9_1_23833", "HTA9_1_23834", "HTA9_1_23835", "HTA9_1_23836", "HTA9_1_23837", "HTA9_1_23838", "HTA9_1_23839", "HTA9_1_23840", "HTA9_1_23841", "HTA9_1_23842", "HTA9_1_23843", "HTA9_1_23844", "HTA9_1_23845", "HTA9_1_23846", "HTA9_1_23847", "HTA9_1_23848", "HTA9_1_23849", "HTA9_1_23850", "HTA9_1_23851", "HTA9_1_23852", "HTA9_1_23853", "HTA9_1_23854", "HTA9_1_23855", "HTA9_1_23856", "HTA9_1_23857", "HTA9_1_23858", "HTA9_1_23859", "HTA9_1_23860", "HTA9_1_23861", "HTA9_1_23862", "HTA9_1_23863", "HTA9_1_23864", "HTA9_1_23865", "HTA9_1_23866", "HTA9_1_23867", "HTA9_1_23868", "HTA9_1_23869", "HTA9_1_23870", "HTA9_1_23871", "HTA9_1_23872", "HTA9_1_23873", "HTA9_1_23874", "HTA9_1_23875", "HTA9_1_23876", "HTA9_1_23877", "HTA9_1_23878", "HTA9_1_23879", "HTA9_1_23880", "HTA9_1_23881", "HTA9_1_23882", "HTA9_1_23883", "HTA9_1_23884", "HTA9_1_23885", "HTA9_1_23886", "HTA9_1_23887", "HTA9_1_23888", "HTA9_1_23889", "HTA9_1_23890", "HTA9_1_23891", "HTA9_1_23892", "HTA9_1_23893", "HTA9_1_23894", "HTA9_1_23895", "HTA9_1_23896", "HTA9_1_23897", "HTA9_1_23898", "HTA9_1_23899", "HTA9_1_23900", "HTA9_1_23901", "HTA9_1_23902", "HTA9_1_23903", "HTA9_1_23904", "HTA9_1_23905", "HTA9_1_23906", "HTA9_1_23907", "HTA9_1_23908", "HTA9_1_23909", "HTA9_1_23910", "HTA9_1_23911", "HTA9_1_23912", "HTA9_1_23913", "HTA9_1_23914", "HTA9_1_23915", "HTA9_1_23916", "HTA9_1_23917", "HTA9_1_23918", "HTA9_1_23919", "HTA9_1_23920", "HTA9_1_23921", "HTA9_1_23922", "HTA9_1_23923", "HTA9_1_23924", "HTA9_1_23925", "HTA9_1_23926", "HTA9_1_23927", "HTA9_1_23928", "HTA9_1_23929", "HTA9_1_23930", "HTA9_1_23931", "HTA9_1_23932", "HTA9_1_23933", "HTA9_1_23934", "HTA9_1_23935", "HTA9_1_23936", "HTA9_1_23937", "HTA9_1_23938", "HTA9_1_23939", "HTA9_1_23940", "HTA9_1_23941", "HTA9_1_23942", "HTA9_1_23943", "HTA9_1_23944", "HTA9_1_23945", "HTA9_1_23946", "HTA9_1_23947", "HTA9_1_23948", "HTA9_1_23949", "HTA9_1_23950", "HTA9_1_23951", "HTA9_1_23952", "HTA9_1_23953", "HTA9_1_23954", "HTA9_1_23955", "HTA9_1_23956", "HTA9_1_23957", "HTA9_1_23958", "HTA9_1_23959", "HTA9_1_23960", "HTA9_1_23961", "HTA9_1_23962", "HTA9_1_23963", "HTA9_1_23964", "HTA9_1_23965", "HTA9_1_23966", "HTA9_1_23967", "HTA9_1_23968", "HTA9_1_23969", "HTA9_1_23970", "HTA9_1_23971", "HTA9_1_23972", "HTA9_1_23973", "HTA9_1_23974", "HTA9_1_23975", "HTA9_1_23976", "HTA9_1_23977", "HTA9_1_23978", "HTA9_1_23979", "HTA9_1_23980", "HTA9_1_23981", "HTA9_1_23982", "HTA9_1_23983", "HTA9_1_23984", "HTA9_1_23985", "HTA9_1_23986", "HTA9_1_23987", "HTA9_1_23988", "HTA9_1_23989", "HTA9_1_23990", "HTA9_1_23991", "HTA9_1_23992", "HTA9_1_23993", "HTA9_1_23994", "HTA9_1_23995", "HTA9_1_23996", "HTA9_1_23997", "HTA9_1_23998", "HTA9_1_23999", "HTA9_1_24000", "HTA9_1_24001", "HTA9_1_24002", "HTA9_1_24003", "HTA9_1_24004", "HTA9_1_24005", "HTA9_1_24006", "HTA9_1_24007", "HTA9_1_24008", "HTA9_1_24009", "HTA9_1_24010", "HTA9_1_24011", "HTA9_1_24012", "HTA9_1_24013", "HTA9_1_24014", "HTA9_1_24015", "HTA9_1_24016", "HTA9_1_24017", "HTA9_1_24018", "HTA9_1_24019", "HTA9_1_24020", "HTA9_1_24021", "HTA9_1_24022", "HTA9_1_24023", "HTA9_1_24024", "HTA9_1_24025", "HTA9_1_24026", "HTA9_1_24027", "HTA9_1_24028", "HTA9_1_24029", "HTA9_1_24030", "HTA9_1_24031", "HTA9_1_24032", "HTA9_1_24033", "HTA9_1_24034", "HTA9_1_24035", "HTA9_1_24036", "HTA9_1_24037", "HTA9_1_24038", "HTA9_1_24039", "HTA9_1_24040", "HTA9_1_24041", "HTA9_1_24042", "HTA9_1_24043", "HTA9_1_24044", "HTA9_1_24045", "HTA9_1_24046", "HTA9_1_24047", "HTA9_1_24048", "HTA9_1_24049", "HTA9_1_24050", "HTA9_1_24051", "HTA9_1_24052", "HTA9_1_24053", "HTA9_1_24054", "HTA9_1_24055", "HTA9_1_24056", "HTA9_1_24057", "HTA9_1_24058", "HTA9_1_24059", "HTA9_1_24060", "HTA9_1_24061", "HTA9_1_24062", "HTA9_1_24063", "HTA9_1_24064", "HTA9_1_24065", "HTA9_1_24066", "HTA9_1_24067", "HTA9_1_24068", "HTA9_1_24069", "HTA9_1_24070", "HTA9_1_24071", "HTA9_1_24072", "HTA9_1_24073", "HTA9_1_24074", "HTA9_1_24075", "HTA9_1_24076", "HTA9_1_24077", "HTA9_1_24078", "HTA9_1_24079", "HTA9_1_24080", "HTA9_1_24081", "HTA9_1_24082", "HTA9_1_24083", "HTA9_1_24084", "HTA9_1_24085", "HTA9_1_24086", "HTA9_1_24087", "HTA9_1_24088", "HTA9_1_24089", "HTA9_1_24090", "HTA9_1_24091", "HTA9_1_24092", "HTA9_1_24093", "HTA9_1_24094", "HTA9_1_24095", "HTA9_1_24096", "HTA9_1_24097", "HTA9_1_24098", "HTA9_1_24099", "HTA9_1_24100", "HTA9_1_24101", "HTA9_1_24102", "HTA9_1_24103", "HTA9_1_24104", "HTA9_1_24105", "HTA9_1_24106", "HTA9_1_24107", "HTA9_1_24108", "HTA9_1_24109", "HTA9_1_24110", "HTA9_1_24111", "HTA9_1_24112", "HTA9_1_24113", "HTA9_1_24114", "HTA9_1_24115", "HTA9_1_24116", "HTA9_1_24117", "HTA9_1_24118", "HTA9_1_24119", "HTA9_1_24120", "HTA9_1_24121", "HTA9_1_24122", "HTA9_1_24123", "HTA9_1_24124", "HTA9_1_24125", "HTA9_1_24126", "HTA9_1_24127", "HTA9_1_24128", "HTA9_1_24129", "HTA9_1_24130", "HTA9_1_24131", "HTA9_1_24132", "HTA9_1_24133", "HTA9_1_24134", "HTA9_1_24135", "HTA9_1_24136", "HTA9_1_24137", "HTA9_1_24138", "HTA9_1_24139", "HTA9_1_24140", "HTA9_1_24141", "HTA9_1_24142", "HTA9_1_24143", "HTA9_1_24144", "HTA9_1_24145", "HTA9_1_24146", "HTA9_1_24147", "HTA9_1_24148", "HTA9_1_24149", "HTA9_1_24150", "HTA9_1_24151", "HTA9_1_24152", "HTA9_1_24153", "HTA9_1_24154", "HTA9_1_24155", "HTA9_1_24156", "HTA9_1_24157", "HTA9_1_24158", "HTA9_1_24159", "HTA9_1_24160", "HTA9_1_24161", "HTA9_1_24162", "HTA9_1_24163", "HTA9_1_24164", "HTA9_1_24165", "HTA9_1_24166", "HTA9_1_24167", "HTA9_1_24168", "HTA9_1_24169", "HTA9_1_24170", "HTA9_1_24171", "HTA9_1_24172", "HTA9_1_24173", "HTA9_1_24174", "HTA9_1_24175", "HTA9_1_24176", "HTA9_1_24177", "HTA9_1_24178", "HTA9_1_24179", "HTA9_1_24180", "HTA9_1_24181", "HTA9_1_24182", "HTA9_1_24183", "HTA9_1_24184", "HTA9_1_24185", "HTA9_1_24186", "HTA9_1_24187", "HTA9_1_24188", "HTA9_1_24189", "HTA9_1_24190", "HTA9_1_24191", "HTA9_1_24192", "HTA9_1_24193", "HTA9_1_24194", "HTA9_1_24195", "HTA9_1_24196", "HTA9_1_24197", "HTA9_1_24198", "HTA9_1_24199", "HTA9_1_24200", "HTA9_1_24201", "HTA9_1_24202", "HTA9_1_24203", "HTA9_1_24204", "HTA9_1_24205", "HTA9_1_24206", "HTA9_1_24207", "HTA9_1_24208", "HTA9_1_24209", "HTA9_1_24210", "HTA9_1_24211", "HTA9_1_24212", "HTA9_1_24213", "HTA9_1_24214", "HTA9_1_24215", "HTA9_1_24216", "HTA9_1_24217", "HTA9_1_24218", "HTA9_1_24219", "HTA9_1_24220", "HTA9_1_24221", "HTA9_1_24222", "HTA9_1_24223", "HTA9_1_24224", "HTA9_1_24225", "HTA9_1_24226", "HTA9_1_24227", "HTA9_1_24228", "HTA9_1_24229", "HTA9_1_24230", "HTA9_1_24231", "HTA9_1_24232", "HTA9_1_24233", "HTA9_1_24234", "HTA9_1_24235", "HTA9_1_24236", "HTA9_1_24237", "HTA9_1_24238", "HTA9_1_24239", "HTA9_1_24240", "HTA9_1_24241", "HTA9_1_24242", "HTA9_1_24243", "HTA9_1_24244", "HTA9_1_24245", "HTA9_1_24246", "HTA9_1_24247", "HTA9_1_24248", "HTA9_1_24249", "HTA9_1_24250", "HTA9_1_24251", "HTA9_1_24252", "HTA9_1_24253", "HTA9_1_24254", "HTA9_1_24255", "HTA9_1_24256", "HTA9_1_24257", "HTA9_1_24258", "HTA9_1_24259", "HTA9_1_24260", "HTA9_1_24261", "HTA9_1_24262", "HTA9_1_24263", "HTA9_1_24264", "HTA9_1_24265", "HTA9_1_24266", "HTA9_1_24267", "HTA9_1_24268", "HTA9_1_24269", "HTA9_1_24270", "HTA9_1_24271", "HTA9_1_24272", "HTA9_1_24273", "HTA9_1_24274", "HTA9_1_24275", "HTA9_1_24276", "HTA9_1_24277", "HTA9_1_24278", "HTA9_1_24279", "HTA9_1_24280", "HTA9_1_24281", "HTA9_1_24282", "HTA9_1_24283", "HTA9_1_24284", "HTA9_1_24285", "HTA9_1_24286", "HTA9_1_24287", "HTA9_1_24288", "HTA9_1_24289", "HTA9_1_24290", "HTA9_1_24291", "HTA9_1_24292", "HTA9_1_24293", "HTA9_1_24294", "HTA9_1_24295", "HTA9_1_24296", "HTA9_1_24297", "HTA9_1_24298", "HTA9_1_24299", "HTA9_1_24300", "HTA9_1_24301", "HTA9_1_24302", "HTA9_1_24303", "HTA9_1_24304", "HTA9_1_24305", "HTA9_1_24306", "HTA9_1_24307", "HTA9_1_24308", "HTA9_1_24309", "HTA9_1_24310", "HTA9_1_24311", "HTA9_1_24312", "HTA9_1_24313", "HTA9_1_24314", "HTA9_1_24315", "HTA9_1_24316", "HTA9_1_24317", "HTA9_1_24318", "HTA9_1_24319", "HTA9_1_24320", "HTA9_1_24321", "HTA9_1_24322", "HTA9_1_24323", "HTA9_1_24324", "HTA9_1_24325", "HTA9_1_24326", "HTA9_1_24327", "HTA9_1_24328", "HTA9_1_24329", "HTA9_1_24330", "HTA9_1_24331", "HTA9_1_24332", "HTA9_1_24333", "HTA9_1_24334", "HTA9_1_24335", "HTA9_1_24336", "HTA9_1_24337", "HTA9_1_24338", "HTA9_1_24339", "HTA9_1_24340", "HTA9_1_24341", "HTA9_1_24342", "HTA9_1_24343", "HTA9_1_24344", "HTA9_1_24345", "HTA9_1_24346", "HTA9_1_24347", "HTA9_1_24348", "HTA9_1_24349", "HTA9_1_24350", "HTA9_1_24351", "HTA9_1_24352", "HTA9_1_24353", "HTA9_1_24354", "HTA9_1_24355", "HTA9_1_24356", "HTA9_1_24357", "HTA9_1_24358", "HTA9_1_24359", "HTA9_1_24360", "HTA9_1_24361", "HTA9_1_24362", "HTA9_1_24363", "HTA9_1_24364", "HTA9_1_24365", "HTA9_1_24366", "HTA9_1_24367", "HTA9_1_24368", "HTA9_1_24369", "HTA9_1_24370", "HTA9_1_24371", "HTA9_1_24372", "HTA9_1_24373", "HTA9_1_24374", "HTA9_1_24375", "HTA9_1_24376", "HTA9_1_24377", "HTA9_1_24378", "HTA9_1_24379", "HTA9_1_24380", "HTA9_1_24381", "HTA9_1_24382", "HTA9_1_24383", "HTA9_1_24384", "HTA9_1_24385", "HTA9_1_24386", "HTA9_1_24387", "HTA9_1_24388", "HTA9_1_24389", "HTA9_1_24390", "HTA9_1_24391", "HTA9_1_24392", "HTA9_1_24393", "HTA9_1_24394", "HTA9_1_24395", "HTA9_1_24396", "HTA9_1_24397", "HTA9_1_24398", "HTA9_1_24399", "HTA9_1_24400", "HTA9_1_24401", "HTA9_1_24402", "HTA9_1_24403", "HTA9_1_24404", "HTA9_1_24405", "HTA9_1_24406", "HTA9_1_24407", "HTA9_1_24408", "HTA9_1_24409", "HTA9_1_24410", "HTA9_1_24411", "HTA9_1_24412", "HTA9_1_24413", "HTA9_1_24414", "HTA9_1_24415", "HTA9_1_24416", "HTA9_1_24417", "HTA9_1_24418", "HTA9_1_24419", "HTA9_1_24420", "HTA9_1_24421", "HTA9_1_24422", "HTA9_1_24423", "HTA9_1_24424", "HTA9_1_24425", "HTA9_1_24426", "HTA9_1_24427", "HTA9_1_24428", "HTA9_1_24429", "HTA9_1_24430", "HTA9_1_24431", "HTA9_1_24432", "HTA9_1_24433", "HTA9_1_24434", "HTA9_1_24435", "HTA9_1_24436", "HTA9_1_24437", "HTA9_1_24438", "HTA9_1_24439", "HTA9_1_24440", "HTA9_1_24441", "HTA9_1_24442", "HTA9_1_24443", "HTA9_1_24444", "HTA9_1_24445", "HTA9_1_24446", "HTA9_1_24447", "HTA9_1_24448", "HTA9_1_24449", "HTA9_1_24450", "HTA9_1_24451", "HTA9_1_24452", "HTA9_1_24453", "HTA9_1_24454", "HTA9_1_24455", "HTA9_1_24456", "HTA9_1_24457", "HTA9_1_24458", "HTA9_1_24459", "HTA9_1_24460", "HTA9_1_24461", "HTA9_1_24462", "HTA9_1_24463", "HTA9_1_24464", "HTA9_1_24465", "HTA9_1_24466", "HTA9_1_24467", "HTA9_1_24468", "HTA9_1_24469", "HTA9_1_24470", "HTA9_1_24471", "HTA9_1_24472", "HTA9_1_24473", "HTA9_1_24474", "HTA9_1_24475", "HTA9_1_24476", "HTA9_1_24477", "HTA9_1_24478", "HTA9_1_24479", "HTA9_1_24480", "HTA9_1_24481", "HTA9_1_24482", "HTA9_1_24483", "HTA9_1_24484", "HTA9_1_24485", "HTA9_1_24486", "HTA9_1_24487", "HTA9_1_24488", "HTA9_1_24489", "HTA9_1_24490", "HTA9_1_24491", "HTA9_1_24492", "HTA9_1_24493", "HTA9_1_24494", "HTA9_1_24495", "HTA9_1_24496", "HTA9_1_24497", "HTA9_1_24498", "HTA9_1_24499", "HTA9_1_24500", "HTA9_1_24501", "HTA9_1_24502", "HTA9_1_24503", "HTA9_1_24504", "HTA9_1_24505", "HTA9_1_24506", "HTA9_1_24507", "HTA9_1_24508", "HTA9_1_24509", "HTA9_1_24510", "HTA9_1_24511", "HTA9_1_24512", "HTA9_1_24513", "HTA9_1_24514", "HTA9_1_24515", "HTA9_1_24516", "HTA9_1_24517", "HTA9_1_24518", "HTA9_1_24519", "HTA9_1_24520", "HTA9_1_24521", "HTA9_1_24522", "HTA9_1_24523", "HTA9_1_24524", "HTA9_1_24525", "HTA9_1_24526", "HTA9_1_24527", "HTA9_1_24528", "HTA9_1_24529", "HTA9_1_24530", "HTA9_1_24531", "HTA9_1_24532", "HTA9_1_24533", "HTA9_1_24534", "HTA9_1_24535", "HTA9_1_24536", "HTA9_1_24537", "HTA9_1_24538", "HTA9_1_24539", "HTA9_1_24540", "HTA9_1_24541", "HTA9_1_24542", "HTA9_1_24543", "HTA9_1_24544", "HTA9_1_24545", "HTA9_1_24546", "HTA9_1_24547", "HTA9_1_24548", "HTA9_1_24549", "HTA9_1_24550", "HTA9_1_24551", "HTA9_1_24552", "HTA9_1_24553", "HTA9_1_24554", "HTA9_1_24555", "HTA9_1_24556", "HTA9_1_24557", "HTA9_1_24558", "HTA9_1_24559", "HTA9_1_24560", "HTA9_1_24561", "HTA9_1_24562", "HTA9_1_24563", "HTA9_1_24564", "HTA9_1_24565", "HTA9_1_24566", "HTA9_1_24567", "HTA9_1_24568", "HTA9_1_24569", "HTA9_1_24570", "HTA9_1_24571", "HTA9_1_24572", "HTA9_1_24573", "HTA9_1_24574", "HTA9_1_24575", "HTA9_1_24576", "HTA9_1_24577", "HTA9_1_24578", "HTA9_1_24579", "HTA9_1_24580", "HTA9_1_24581", "HTA9_1_24582", "HTA9_1_24583", "HTA9_1_24584", "HTA9_1_24585", "HTA9_1_24586", "HTA9_1_24587", "HTA9_1_24588", "HTA9_1_24589", "HTA9_1_24590", "HTA9_1_24591", "HTA9_1_24592", "HTA9_1_24593", "HTA9_1_24594", "HTA9_1_24595", "HTA9_1_24596", "HTA9_1_24597", "HTA9_1_24598", "HTA9_1_24599", "HTA9_1_24600", "HTA9_1_24601", "HTA9_1_24602", "HTA9_1_24603", "HTA9_1_24604", "HTA9_1_24605", "HTA9_1_24606", "HTA9_1_24607", "HTA9_1_24608", "HTA9_1_24609", "HTA9_1_24610", "HTA9_1_24611", "HTA9_1_24612", "HTA9_1_24613", "HTA9_1_24614", "HTA9_1_24615", "HTA9_1_24616", "HTA9_1_24617", "HTA9_1_24618", "HTA9_1_24619", "HTA9_1_24620", "HTA9_1_24621", "HTA9_1_24622", "HTA9_1_24623", "HTA9_1_24624", "HTA9_1_24625", "HTA9_1_24626", "HTA9_1_24627", "HTA9_1_24628", "HTA9_1_24629", "HTA9_1_24630", "HTA9_1_24631", "HTA9_1_24632", "HTA9_1_24633", "HTA9_1_24634", "HTA9_1_24635", "HTA9_1_24636", "HTA9_1_24637", "HTA9_1_24638", "HTA9_1_24639", "HTA9_1_24640", "HTA9_1_24641", "HTA9_1_24642", "HTA9_1_24643", "HTA9_1_24644", "HTA9_1_24645", "HTA9_1_24646", "HTA9_1_24647", "HTA9_1_24648", "HTA9_1_24649", "HTA9_1_24650", "HTA9_1_24651", "HTA9_1_24652", "HTA9_1_24653", "HTA9_1_24654", "HTA9_1_24655", "HTA9_1_24656", "HTA9_1_24657", "HTA9_1_24658", "HTA9_1_24659", "HTA9_1_24660", "HTA9_1_24661", "HTA9_1_24662", "HTA9_1_24663", "HTA9_1_24664", "HTA9_1_24665", "HTA9_1_24666", "HTA9_1_24667", "HTA9_1_24668", "HTA9_1_24669", "HTA9_1_24670", "HTA9_1_24671", "HTA9_1_24672", "HTA9_1_24673", "HTA9_1_24674", "HTA9_1_24675", "HTA9_1_24676", "HTA9_1_24677", "HTA9_1_24678", "HTA9_1_24679", "HTA9_1_24680", "HTA9_1_24681", "HTA9_1_24682", "HTA9_1_24683", "HTA9_1_24684", "HTA9_1_24685", "HTA9_1_24686", "HTA9_1_24687", "HTA9_1_24688", "HTA9_1_24689", "HTA9_1_24690", "HTA9_1_24691", "HTA9_1_24692", "HTA9_1_24693", "HTA9_1_24694", "HTA9_1_24695", "HTA9_1_24696", "HTA9_1_24697", "HTA9_1_24698", "HTA9_1_24699", "HTA9_1_24700", "HTA9_1_24701", "HTA9_1_24702", "HTA9_1_24703", "HTA9_1_24704", "HTA9_1_24705", "HTA9_1_24706", "HTA9_1_24707", "HTA9_1_24708", "HTA9_1_24709", "HTA9_1_24710", "HTA9_1_24711", "HTA9_1_24712", "HTA9_1_24713", "HTA9_1_24714", "HTA9_1_24715", "HTA9_1_24716", "HTA9_1_24717", "HTA9_1_24718", "HTA9_1_24719", "HTA9_1_24720", "HTA9_1_24721", "HTA9_1_24722", "HTA9_1_24723", "HTA9_1_24724", "HTA9_1_24725", "HTA9_1_24726", "HTA9_1_24727", "HTA9_1_24728", "HTA9_1_24729", "HTA9_1_24730", "HTA9_1_24731", "HTA9_1_24732", "HTA9_1_24733", "HTA9_1_24734", "HTA9_1_24735", "HTA9_1_24736", "HTA9_1_24737", "HTA9_1_24738", "HTA9_1_24739", "HTA9_1_24740", "HTA9_1_24741", "HTA9_1_24742", "HTA9_1_24743", "HTA9_1_24744", "HTA9_1_24745", "HTA9_1_24746", "HTA9_1_24747", "HTA9_1_24748", "HTA9_1_24749", "HTA9_1_24750", "HTA9_1_24751", "HTA9_1_24752", "HTA9_1_24753", "HTA9_1_24754", "HTA9_1_24755", "HTA9_1_24756", "HTA9_1_24757", "HTA9_1_24758", "HTA9_1_24759", "HTA9_1_24760", "HTA9_1_24761", "HTA9_1_24762", "HTA9_1_24763", "HTA9_1_24764", "HTA9_1_24765", "HTA9_1_24766", "HTA9_1_24767", "HTA9_1_24768", "HTA9_1_24769", "HTA9_1_24770", "HTA9_1_24771", "HTA9_1_24772", "HTA9_1_24773", "HTA9_1_24774", "HTA9_1_24775", "HTA9_1_24776", "HTA9_1_24777", "HTA9_1_24778", "HTA9_1_24779", "HTA9_1_24780", "HTA9_1_24781", "HTA9_1_24782", "HTA9_1_24783", "HTA9_1_24784", "HTA9_1_24785", "HTA9_1_24786", "HTA9_1_24787", "HTA9_1_24788", "HTA9_1_24789", "HTA9_1_24790", "HTA9_1_24791", "HTA9_1_24792", "HTA9_1_24793", "HTA9_1_24794", "HTA9_1_24795", "HTA9_1_24796", "HTA9_1_24797", "HTA9_1_24798", "HTA9_1_24799", "HTA9_1_24800", "HTA9_1_24801", "HTA9_1_24802", "HTA9_1_24803", "HTA9_1_24804", "HTA9_1_24805", "HTA9_1_24806", "HTA9_1_24807", "HTA9_1_24808", "HTA9_1_24809", "HTA9_1_24810", "HTA9_1_24811", "HTA9_1_24812", "HTA9_1_24813", "HTA9_1_24814", "HTA9_1_24815", "HTA9_1_24816", "HTA9_1_24817", "HTA9_1_24818", "HTA9_1_24819", "HTA9_1_24820", "HTA9_1_24821", "HTA9_1_24822", "HTA9_1_24823", "HTA9_1_24824", "HTA9_1_24825", "HTA9_1_24826", "HTA9_1_24827", "HTA9_1_24828", "HTA9_1_24829", "HTA9_1_24830", "HTA9_1_24831", "HTA9_1_24832", "HTA9_1_24833", "HTA9_1_24834", "HTA9_1_24835", "HTA9_1_24836", "HTA9_1_24837", "HTA9_1_24838", "HTA9_1_24839", "HTA9_1_24840", "HTA9_1_24841", "HTA9_1_24842", "HTA9_1_24843", "HTA9_1_24844", "HTA9_1_24845", "HTA9_1_24846", "HTA9_1_24847", "HTA9_1_24848", "HTA9_1_24849", "HTA9_1_24850", "HTA9_1_24851", "HTA9_1_24852", "HTA9_1_24853", "HTA9_1_24854", "HTA9_1_24855", "HTA9_1_24856", "HTA9_1_24857", "HTA9_1_24858", "HTA9_1_24859", "HTA9_1_24860", "HTA9_1_24861", "HTA9_1_24862", "HTA9_1_24863", "HTA9_1_24864", "HTA9_1_24865", "HTA9_1_24866", "HTA9_1_24867", "HTA9_1_24868", "HTA9_1_24869", "HTA9_1_24870", "HTA9_1_24871", "HTA9_1_24872", "HTA9_1_24873", "HTA9_1_24874", "HTA9_1_24875", "HTA9_1_24876", "HTA9_1_24877", "HTA9_1_24878", "HTA9_1_24879", "HTA9_1_24880", "HTA9_1_24881", "HTA9_1_24882", "HTA9_1_24883", "HTA9_1_24884", "HTA9_1_24885", "HTA9_1_24886", "HTA9_1_24887", "HTA9_1_24888", "HTA9_1_24889", "HTA9_1_24890", "HTA9_1_24891", "HTA9_1_24892", "HTA9_1_24893", "HTA9_1_24894", "HTA9_1_24895", "HTA9_1_24896", "HTA9_1_24897", "HTA9_1_24898", "HTA9_1_24899", "HTA9_1_24900", "HTA9_1_24901", "HTA9_1_24902", "HTA9_1_24903", "HTA9_1_24904", "HTA9_1_24905", "HTA9_1_24906", "HTA9_1_24907", "HTA9_1_24908", "HTA9_1_24909", "HTA9_1_24910", "HTA9_1_24911", "HTA9_1_24912", "HTA9_1_24913", "HTA9_1_24914", "HTA9_1_24915", "HTA9_1_24916", "HTA9_1_24917", "HTA9_1_24918", "HTA9_1_24919", "HTA9_1_24920", "HTA9_1_24921", "HTA9_1_24922", "HTA9_1_24923", "HTA9_1_24924", "HTA9_1_24925", "HTA9_1_24926", "HTA9_1_24927", "HTA9_1_24928", "HTA9_1_24929", "HTA9_1_24930", "HTA9_1_24931", "HTA9_1_24932", "HTA9_1_24933", "HTA9_1_24934", "HTA9_1_24935", "HTA9_1_24936", "HTA9_1_24937", "HTA9_1_24938", "HTA9_1_24939", "HTA9_1_24940", "HTA9_1_24941", "HTA9_1_24942", "HTA9_1_24943", "HTA9_1_24944", "HTA9_1_24945", "HTA9_1_24946", "HTA9_1_24947", "HTA9_1_24948", "HTA9_1_24949", "HTA9_1_24950", "HTA9_1_24951", "HTA9_1_24952", "HTA9_1_24953", "HTA9_1_24954", "HTA9_1_24955", "HTA9_1_24956", "HTA9_1_24957", "HTA9_1_24958", "HTA9_1_24959", "HTA9_1_24960", "HTA9_1_24961", "HTA9_1_24962", "HTA9_1_24963", "HTA9_1_24964", "HTA9_1_24965", "HTA9_1_24966", "HTA9_1_24967", "HTA9_1_24968", "HTA9_1_24969", "HTA9_1_24970", "HTA9_1_24971", "HTA9_1_24972", "HTA9_1_24973", "HTA9_1_24974", "HTA9_1_24975", "HTA9_1_24976", "HTA9_1_24977", "HTA9_1_24978", "HTA9_1_24979", "HTA9_1_24980", "HTA9_1_24981", "HTA9_1_24982", "HTA9_1_24983", "HTA9_1_24984", "HTA9_1_24985", "HTA9_1_24986", "HTA9_1_24987", "HTA9_1_24988", "HTA9_1_24989", "HTA9_1_24990", "HTA9_1_24991", "HTA9_1_24992", "HTA9_1_24993", "HTA9_1_24994", "HTA9_1_24995", "HTA9_1_24996", "HTA9_1_24997", "HTA9_1_24998", "HTA9_1_24999", "HTA9_1_25000", "HTA9_1_25001", "HTA9_1_25002", "HTA9_1_25003", "HTA9_1_25004", "HTA9_1_25005", "HTA9_1_25006", "HTA9_1_25007", "HTA9_1_25008", "HTA9_1_25009", "HTA9_1_25010", "HTA9_1_25011", "HTA9_1_25012", "HTA9_1_25013", "HTA9_1_25014", "HTA9_1_25015", "HTA9_1_25016", "HTA9_1_25017", "HTA9_1_25018", "HTA9_1_25019", "HTA9_1_25020", "HTA9_1_25021", "HTA9_1_25022", "HTA9_1_25023", "HTA9_1_25024", "HTA9_1_25025", "HTA9_1_25026", "HTA9_1_25027", "HTA9_1_25028", "HTA9_1_25029", "HTA9_1_25030", "HTA9_1_25031", "HTA9_1_25032", "HTA9_1_25033", "HTA9_1_25034", "HTA9_1_25035", "HTA9_1_25036", "HTA9_1_25037", "HTA9_1_25038", "HTA9_1_25039", "HTA9_1_25040", "HTA9_1_25041", "HTA9_1_25042", "HTA9_1_25043", "HTA9_1_25044", "HTA9_1_25045", "HTA9_1_25046", "HTA9_1_25047", "HTA9_1_25048", "HTA9_1_25049", "HTA9_1_25050", "HTA9_1_25051", "HTA9_1_25052", "HTA9_1_25053", "HTA9_1_25054", "HTA9_1_25055", "HTA9_1_25056", "HTA9_1_25057", "HTA9_1_25058", "HTA9_1_25059", "HTA9_1_25060", "HTA9_1_25061", "HTA9_1_25062", "HTA9_1_25063", "HTA9_1_25064", "HTA9_1_25065", "HTA9_1_25066", "HTA9_1_25067", "HTA9_1_25068", "HTA9_1_25069", "HTA9_1_25070", "HTA9_1_25071", "HTA9_1_25072", "HTA9_1_25073", "HTA9_1_25074", "HTA9_1_25075", "HTA9_1_25076", "HTA9_1_25077", "HTA9_1_25078", "HTA9_1_25079", "HTA9_1_25080", "HTA9_1_25081", "HTA9_1_25082", "HTA9_1_25083", "HTA9_1_25084", "HTA9_1_25085", "HTA9_1_25086", "HTA9_1_25087", "HTA9_1_25088", "HTA9_1_25089", "HTA9_1_25090", "HTA9_1_25091", "HTA9_1_25092", "HTA9_1_25093", "HTA9_1_25094", "HTA9_1_25095", "HTA9_1_25096", "HTA9_1_25097", "HTA9_1_25098", "HTA9_1_25099", "HTA9_1_25100", "HTA9_1_25101", "HTA9_1_25102", "HTA9_1_25103", "HTA9_1_25104", "HTA9_1_25105", "HTA9_1_25106", "HTA9_1_25107", "HTA9_1_25108", "HTA9_1_25109", "HTA9_1_25110", "HTA9_1_25111", "HTA9_1_25112", "HTA9_1_25113", "HTA9_1_25114", "HTA9_1_25115", "HTA9_1_25116", "HTA9_1_25117", "HTA9_1_25118", "HTA9_1_25119", "HTA9_1_25120", "HTA9_1_25121", "HTA9_1_25122", "HTA9_1_25123", "HTA9_1_25124", "HTA9_1_25125", "HTA9_1_25126", "HTA9_1_25127", "HTA9_1_25128", "HTA9_1_25129", "HTA9_1_25130", "HTA9_1_25131", "HTA9_1_25132", "HTA9_1_25133", "HTA9_1_25134", "HTA9_1_25135", "HTA9_1_25136", "HTA9_1_25137", "HTA9_1_25138", "HTA9_1_25139", "HTA9_1_25140", "HTA9_1_25141", "HTA9_1_25142", "HTA9_1_25143", "HTA9_1_25144", "HTA9_1_25145", "HTA9_1_25146", "HTA9_1_25147", "HTA9_1_25148", "HTA9_1_25149", "HTA9_1_25150", "HTA9_1_25151", "HTA9_1_25152", "HTA9_1_25153", "HTA9_1_25154", "HTA9_1_25155", "HTA9_1_25156", "HTA9_1_25157", "HTA9_1_25158", "HTA9_1_25159", "HTA9_1_25160", "HTA9_1_25161", "HTA9_1_25162", "HTA9_1_25163", "HTA9_1_25164", "HTA9_1_25165", "HTA9_1_25166", "HTA9_1_25167", "HTA9_1_25168", "HTA9_1_25169", "HTA9_1_25170", "HTA9_1_25171", "HTA9_1_25172", "HTA9_1_25173", "HTA9_1_25174", "HTA9_1_25175", "HTA9_1_25176", "HTA9_1_25177", "HTA9_1_25178", "HTA9_1_25179", "HTA9_1_25180", "HTA9_1_25181", "HTA9_1_25182", "HTA9_1_25183", "HTA9_1_25184", "HTA9_1_25185", "HTA9_1_25186", "HTA9_1_25187", "HTA9_1_25188", "HTA9_1_25189", "HTA9_1_25190", "HTA9_1_25191", "HTA9_1_25192", "HTA9_1_25193", "HTA9_1_25194", "HTA9_1_25195", "HTA9_1_25196", "HTA9_1_25197", "HTA9_1_25198", "HTA9_1_25199", "HTA9_1_25200", "HTA9_1_25201", "HTA9_1_25202", "HTA9_1_25203", "HTA9_1_25204", "HTA9_1_25205", "HTA9_1_25206", "HTA9_1_25207", "HTA9_1_25208", "HTA9_1_25209", "HTA9_1_25210", "HTA9_1_25211", "HTA9_1_25212", "HTA9_1_25213", "HTA9_1_25214", "HTA9_1_25215", "HTA9_1_25216", "HTA9_1_25217", "HTA9_1_25218", "HTA9_1_25219", "HTA9_1_25220", "HTA9_1_25221", "HTA9_1_25222", "HTA9_1_25223", "HTA9_1_25224", "HTA9_1_25225", "HTA9_1_25226", "HTA9_1_25227", "HTA9_1_25228", "HTA9_1_25229", "HTA9_1_25230", "HTA9_1_25231", "HTA9_1_25232", "HTA9_1_25233", "HTA9_1_25234", "HTA9_1_25235", "HTA9_1_25236", "HTA9_1_25237", "HTA9_1_25238", "HTA9_1_25239", "HTA9_1_25240", "HTA9_1_25241", "HTA9_1_25242", "HTA9_1_25243", "HTA9_1_25244", "HTA9_1_25245", "HTA9_1_25246", "HTA9_1_25247", "HTA9_1_25248", "HTA9_1_25249", "HTA9_1_25250", "HTA9_1_25251", "HTA9_1_25252", "HTA9_1_25253", "HTA9_1_25254", "HTA9_1_25255", "HTA9_1_25256", "HTA9_1_25257", "HTA9_1_25258", "HTA9_1_25259", "HTA9_1_25260", "HTA9_1_25261", "HTA9_1_25262", "HTA9_1_25263", "HTA9_1_25264", "HTA9_1_25265", "HTA9_1_25266", "HTA9_1_25267", "HTA9_1_25268", "HTA9_1_25269", "HTA9_1_25270", "HTA9_1_25271", "HTA9_1_25272", "HTA9_1_25273", "HTA9_1_25274", "HTA9_1_25275", "HTA9_1_25276", "HTA9_1_25277", "HTA9_1_25278", "HTA9_1_25279", "HTA9_1_25280", "HTA9_1_25281", "HTA9_1_25282", "HTA9_1_25283", "HTA9_1_25284", "HTA9_1_25285", "HTA9_1_25286", "HTA9_1_25287", "HTA9_1_25288", "HTA9_1_25289", "HTA9_1_25290", "HTA9_1_25291", "HTA9_1_25292", "HTA9_1_25293", "HTA9_1_25294", "HTA9_1_25295", "HTA9_1_25296", "HTA9_1_25297", "HTA9_1_25298", "HTA9_1_25299", "HTA9_1_25300", "HTA9_1_25301", "HTA9_1_25302", "HTA9_1_25303", "HTA9_1_25304", "HTA9_1_25305", "HTA9_1_25306", "HTA9_1_25307", "HTA9_1_25308", "HTA9_1_25309", "HTA9_1_25310", "HTA9_1_25311", "HTA9_1_25312", "HTA9_1_25313", "HTA9_1_25314", "HTA9_1_25315", "HTA9_1_25316", "HTA9_1_25317", "HTA9_1_25318", "HTA9_1_25319", "HTA9_1_25320", "HTA9_1_25321", "HTA9_1_25322", "HTA9_1_25323", "HTA9_1_25324", "HTA9_1_25325", "HTA9_1_25326", "HTA9_1_25327", "HTA9_1_25328", "HTA9_1_25329", "HTA9_1_25330", "HTA9_1_25331", "HTA9_1_25332", "HTA9_1_25333", "HTA9_1_25334", "HTA9_1_25335", "HTA9_1_25336", "HTA9_1_25337", "HTA9_1_25338", "HTA9_1_25339", "HTA9_1_25340", "HTA9_1_25341", "HTA9_1_25342", "HTA9_1_25343", "HTA9_1_25344", "HTA9_1_25345", "HTA9_1_25346", "HTA9_1_25347", "HTA9_1_25348", "HTA9_1_25349", "HTA9_1_25350", "HTA9_1_25351", "HTA9_1_25352", "HTA9_1_25353", "HTA9_1_25354", "HTA9_1_25355", "HTA9_1_25356", "HTA9_1_25357", "HTA9_1_25358", "HTA9_1_25359", "HTA9_1_25360", "HTA9_1_25361", "HTA9_1_25362", "HTA9_1_25363", "HTA9_1_25364", "HTA9_1_25365", "HTA9_1_25366", "HTA9_1_25367", "HTA9_1_25368", "HTA9_1_25369", "HTA9_1_25370", "HTA9_1_25371", "HTA9_1_25372", "HTA9_1_25373", "HTA9_1_25374", "HTA9_1_25375", "HTA9_1_25376", "HTA9_1_25377", "HTA9_1_25378", "HTA9_1_25379", "HTA9_1_25380", "HTA9_1_25381", "HTA9_1_25382", "HTA9_1_25383", "HTA9_1_25384", "HTA9_1_25385", "HTA9_1_25386", "HTA9_1_25387", "HTA9_1_25388", "HTA9_1_25389", "HTA9_1_25390", "HTA9_1_25391", "HTA9_1_25392", "HTA9_1_25393", "HTA9_1_25394", "HTA9_1_25395", "HTA9_1_25396", "HTA9_1_25397", "HTA9_1_25398", "HTA9_1_25399", "HTA9_1_25400", "HTA9_1_25401", "HTA9_1_25402", "HTA9_1_25403", "HTA9_1_25404", "HTA9_1_25405", "HTA9_1_25406", "HTA9_1_25407", "HTA9_1_25408", "HTA9_1_25409", "HTA9_1_25410", "HTA9_1_25411", "HTA9_1_25412", "HTA9_1_25413", "HTA9_1_25414", "HTA9_1_25415", "HTA9_1_25416", "HTA9_1_25417", "HTA9_1_25418", "HTA9_1_25419", "HTA9_1_25420", "HTA9_1_25421", "HTA9_1_25422", "HTA9_1_25423", "HTA9_1_25424", "HTA9_1_25425", "HTA9_1_25426", "HTA9_1_25427", "HTA9_1_25428", "HTA9_1_25429", "HTA9_1_25430", "HTA9_1_25431", "HTA9_1_25432", "HTA9_1_25433", "HTA9_1_25434", "HTA9_1_25435", "HTA9_1_25436", "HTA9_1_25437", "HTA9_1_25438", "HTA9_1_25439", "HTA9_1_25440", "HTA9_1_25441", "HTA9_1_25442", "HTA9_1_25443", "HTA9_1_25444", "HTA9_1_25445", "HTA9_1_25446", "HTA9_1_25447", "HTA9_1_25448", "HTA9_1_25449", "HTA9_1_25450", "HTA9_1_25451", "HTA9_1_25452", "HTA9_1_25453", "HTA9_1_25454", "HTA9_1_25455", "HTA9_1_25456", "HTA9_1_25457", "HTA9_1_25458", "HTA9_1_25459", "HTA9_1_25460", "HTA9_1_25461", "HTA9_1_25462", "HTA9_1_25463", "HTA9_1_25464", "HTA9_1_25465", "HTA9_1_25466", "HTA9_1_25467", "HTA9_1_25468", "HTA9_1_25469", "HTA9_1_25470", "HTA9_1_25471", "HTA9_1_25472", "HTA9_1_25473", "HTA9_1_25474", "HTA9_1_25475", "HTA9_1_25476", "HTA9_1_25477", "HTA9_1_25478", "HTA9_1_25479", "HTA9_1_25480", "HTA9_1_25481", "HTA9_1_25482", "HTA9_1_25483", "HTA9_1_25484", "HTA9_1_25485", "HTA9_1_25486", "HTA9_1_25487", "HTA9_1_25488", "HTA9_1_25489", "HTA9_1_25490", "HTA9_1_25491", "HTA9_1_25492", "HTA9_1_25493", "HTA9_1_25494", "HTA9_1_25495", "HTA9_1_25496", "HTA9_1_25497", "HTA9_1_25498", "HTA9_1_25499", "HTA9_1_25500", "HTA9_1_25501", "HTA9_1_25502", "HTA9_1_25503", "HTA9_1_25504", "HTA9_1_25505", "HTA9_1_25506", "HTA9_1_25507", "HTA9_1_25508", "HTA9_1_25509", "HTA9_1_25510", "HTA9_1_25511", "HTA9_1_25512", "HTA9_1_25513", "HTA9_1_25514", "HTA9_1_25515", "HTA9_1_25516", "HTA9_1_25517", "HTA9_1_25518", "HTA9_1_25519", "HTA9_1_25520", "HTA9_1_25521", "HTA9_1_25522", "HTA9_1_25523", "HTA9_1_25524", "HTA9_1_25525", "HTA9_1_25526", "HTA9_1_25527", "HTA9_1_25528", "HTA9_1_25529", "HTA9_1_25530", "HTA9_1_25531", "HTA9_1_25532", "HTA9_1_25533", "HTA9_1_25534", "HTA9_1_25535", "HTA9_1_25536", "HTA9_1_25537", "HTA9_1_25538", "HTA9_1_25539", "HTA9_1_25540", "HTA9_1_25541", "HTA9_1_25542", "HTA9_1_25543", "HTA9_1_25544", "HTA9_1_25545", "HTA9_1_25546", "HTA9_1_25547", "HTA9_1_25548", "HTA9_1_25549", "HTA9_1_25550", "HTA9_1_25551", "HTA9_1_25552", "HTA9_1_25553", "HTA9_1_25554", "HTA9_1_25555", "HTA9_1_25556", "HTA9_1_25557", "HTA9_1_25558", "HTA9_1_25559", "HTA9_1_25560", "HTA9_1_25561", "HTA9_1_25562", "HTA9_1_25563", "HTA9_1_25564", "HTA9_1_25565", "HTA9_1_25566", "HTA9_1_25567", "HTA9_1_25568", "HTA9_1_25569", "HTA9_1_25570", "HTA9_1_25571", "HTA9_1_25572", "HTA9_1_25573", "HTA9_1_25574", "HTA9_1_25575", "HTA9_1_25576", "HTA9_1_25577", "HTA9_1_25578", "HTA9_1_25579", "HTA9_1_25580", "HTA9_1_25581", "HTA9_1_25582", "HTA9_1_25583", "HTA9_1_25584", "HTA9_1_25585", "HTA9_1_25586", "HTA9_1_25587", "HTA9_1_25588", "HTA9_1_25589", "HTA9_1_25590", "HTA9_1_25591", "HTA9_1_25592", "HTA9_1_25593", "HTA9_1_25594", "HTA9_1_25595", "HTA9_1_25596", "HTA9_1_25597", "HTA9_1_25598", "HTA9_1_25599", "HTA9_1_25600", "HTA9_1_25601", "HTA9_1_25602", "HTA9_1_25603", "HTA9_1_25604", "HTA9_1_25605", "HTA9_1_25606", "HTA9_1_25607", "HTA9_1_25608", "HTA9_1_25609", "HTA9_1_25610", "HTA9_1_25611", "HTA9_1_25612", "HTA9_1_25613", "HTA9_1_25614", "HTA9_1_25615", "HTA9_1_25616", "HTA9_1_25617", "HTA9_1_25618", "HTA9_1_25619", "HTA9_1_25620", "HTA9_1_25621", "HTA9_1_25622", "HTA9_1_25623", "HTA9_1_25624", "HTA9_1_25625", "HTA9_1_25626", "HTA9_1_25627", "HTA9_1_25628", "HTA9_1_25629", "HTA9_1_25630", "HTA9_1_25631", "HTA9_1_25632", "HTA9_1_25633", "HTA9_1_25634", "HTA9_1_25635", "HTA9_1_25636", "HTA9_1_25637", "HTA9_1_25638", "HTA9_1_25639", "HTA9_1_25640", "HTA9_1_25641", "HTA9_1_25642", "HTA9_1_25643", "HTA9_1_25644", "HTA9_1_25645", "HTA9_1_25646", "HTA9_1_25647", "HTA9_1_25648", "HTA9_1_25649", "HTA9_1_25650", "HTA9_1_25651", "HTA9_1_25652", "HTA9_1_25653", "HTA9_1_25654", "HTA9_1_25655", "HTA9_1_25656", "HTA9_1_25657", "HTA9_1_25658", "HTA9_1_25659", "HTA9_1_25660", "HTA9_1_25661", "HTA9_1_25662", "HTA9_1_25663", "HTA9_1_25664", "HTA9_1_25665", "HTA9_1_25666", "HTA9_1_25667", "HTA9_1_25668", "HTA9_1_25669", "HTA9_1_25670", "HTA9_1_25671", "HTA9_1_25672", "HTA9_1_25673", "HTA9_1_25674", "HTA9_1_25675", "HTA9_1_25676", "HTA9_1_25677", "HTA9_1_25678", "HTA9_1_25679", "HTA9_1_25680", "HTA9_1_25681", "HTA9_1_25682", "HTA9_1_25683", "HTA9_1_25684", "HTA9_1_25685", "HTA9_1_25686", "HTA9_1_25687", "HTA9_1_25688", "HTA9_1_25689", "HTA9_1_25690", "HTA9_1_25691", "HTA9_1_25692", "HTA9_1_25693", "HTA9_1_25694", "HTA9_1_25695", "HTA9_1_25696", "HTA9_1_25697", "HTA9_1_25698", "HTA9_1_25699", "HTA9_1_25700", "HTA9_1_25701", "HTA9_1_25702", "HTA9_1_25703", "HTA9_1_25704", "HTA9_1_25705", "HTA9_1_25706", "HTA9_1_25707", "HTA9_1_25708", "HTA9_1_25709", "HTA9_1_25710", "HTA9_1_25711", "HTA9_1_25712", "HTA9_1_25713", "HTA9_1_25714", "HTA9_1_25715", "HTA9_1_25716", "HTA9_1_25717", "HTA9_1_25718", "HTA9_1_25719", "HTA9_1_25720", "HTA9_1_25721", "HTA9_1_25722", "HTA9_1_25723", "HTA9_1_25724", "HTA9_1_25725", "HTA9_1_25726", "HTA9_1_25727", "HTA9_1_25728", "HTA9_1_25729", "HTA9_1_25730", "HTA9_1_25731", "HTA9_1_25732", "HTA9_1_25733", "HTA9_1_25734", "HTA9_1_25735", "HTA9_1_25736", "HTA9_1_25737", "HTA9_1_25738", "HTA9_1_25739", "HTA9_1_25740", "HTA9_1_25741", "HTA9_1_25742", "HTA9_1_25743", "HTA9_1_25744", "HTA9_1_25745", "HTA9_1_25746", "HTA9_1_25747", "HTA9_1_25748", "HTA9_1_25749", "HTA9_1_25750", "HTA9_1_25751", "HTA9_1_25752", "HTA9_1_25753", "HTA9_1_25754", "HTA9_1_25755", "HTA9_1_25756", "HTA9_1_25757", "HTA9_1_25758", "HTA9_1_25759", "HTA9_1_25760", "HTA9_1_25761", "HTA9_1_25762", "HTA9_1_25763", "HTA9_1_25764", "HTA9_1_25765", "HTA9_1_25766", "HTA9_1_25767", "HTA9_1_25768", "HTA9_1_25769", "HTA9_1_25770", "HTA9_1_25771", "HTA9_1_25772", "HTA9_1_25773", "HTA9_1_25774", "HTA9_1_25775", "HTA9_1_25776", "HTA9_1_25777", "HTA9_1_25778", "HTA9_1_25779", "HTA9_1_25780", "HTA9_1_25781", "HTA9_1_25782", "HTA9_1_25783", "HTA9_1_25784", "HTA9_1_25785", "HTA9_1_25786", "HTA9_1_25787", "HTA9_1_25788", "HTA9_1_25789", "HTA9_1_25790", "HTA9_1_25791", "HTA9_1_25792", "HTA9_1_25793", "HTA9_1_25794", "HTA9_1_25795", "HTA9_1_25796", "HTA9_1_25797", "HTA9_1_25798", "HTA9_1_25799", "HTA9_1_25800", "HTA9_1_25801", "HTA9_1_25802", "HTA9_1_25803", "HTA9_1_25804", "HTA9_1_25805", "HTA9_1_25806", "HTA9_1_25807", "HTA9_1_25808", "HTA9_1_25809", "HTA9_1_25810", "HTA9_1_25811", "HTA9_1_25812", "HTA9_1_25813", "HTA9_1_25814", "HTA9_1_25815", "HTA9_1_25816", "HTA9_1_25817", "HTA9_1_25818", "HTA9_1_25819", "HTA9_1_25820", "HTA9_1_25821", "HTA9_1_25822", "HTA9_1_25823", "HTA9_1_25824", "HTA9_1_25825", "HTA9_1_25826", "HTA9_1_25827", "HTA9_1_25828", "HTA9_1_25829", "HTA9_1_25830", "HTA9_1_25831", "HTA9_1_25832", "HTA9_1_25833", "HTA9_1_25834", "HTA9_1_25835", "HTA9_1_25836", "HTA9_1_25837", "HTA9_1_25838", "HTA9_1_25839", "HTA9_1_25840", "HTA9_1_25841", "HTA9_1_25842", "HTA9_1_25843", "HTA9_1_25844", "HTA9_1_25845", "HTA9_1_25846", "HTA9_1_25847", "HTA9_1_25848", "HTA9_1_25849", "HTA9_1_25850", "HTA9_1_25851", "HTA9_1_25852", "HTA9_1_25853", "HTA9_1_25854", "HTA9_1_25855", "HTA9_1_25856", "HTA9_1_25857", "HTA9_1_25858", "HTA9_1_25859", "HTA9_1_25860", "HTA9_1_25861", "HTA9_1_25862", "HTA9_1_25863", "HTA9_1_25864", "HTA9_1_25865", "HTA9_1_25866", "HTA9_1_25867", "HTA9_1_25868", "HTA9_1_25869", "HTA9_1_25870", "HTA9_1_25871", "HTA9_1_25872", "HTA9_1_25873", "HTA9_1_25874", "HTA9_1_25875", "HTA9_1_25876", "HTA9_1_25877", "HTA9_1_25878", "HTA9_1_25879", "HTA9_1_25880", "HTA9_1_25881", "HTA9_1_25882", "HTA9_1_25883", "HTA9_1_25884", "HTA9_1_25885", "HTA9_1_25886", "HTA9_1_25887", "HTA9_1_25888", "HTA9_1_25889", "HTA9_1_25890", "HTA9_1_25891", "HTA9_1_25892", "HTA9_1_25893", "HTA9_1_25894", "HTA9_1_25895", "HTA9_1_25896", "HTA9_1_25897", "HTA9_1_25898", "HTA9_1_25899", "HTA9_1_25900", "HTA9_1_25901", "HTA9_1_25902", "HTA9_1_25903", "HTA9_1_25904", "HTA9_1_25905", "HTA9_1_25906", "HTA9_1_25907", "HTA9_1_25908", "HTA9_1_25909", "HTA9_1_25910", "HTA9_1_25911", "HTA9_1_25912", "HTA9_1_25913", "HTA9_1_25914", "HTA9_1_25915", "HTA9_1_25916", "HTA9_1_25917", "HTA9_1_25918", "HTA9_1_25919", "HTA9_1_25920", "HTA9_1_25921", "HTA9_1_25922", "HTA9_1_25923", "HTA9_1_25924", "HTA9_1_25925", "HTA9_1_25926", "HTA9_1_25927", "HTA9_1_25928", "HTA9_1_25929", "HTA9_1_25930", "HTA9_1_25931", "HTA9_1_25932", "HTA9_1_25933", "HTA9_1_25934", "HTA9_1_25935", "HTA9_1_25936", "HTA9_1_25937", "HTA9_1_25938", "HTA9_1_25939", "HTA9_1_25940", "HTA9_1_25941", "HTA9_1_25942", "HTA9_1_25943", "HTA9_1_25944", "HTA9_1_25945", "HTA9_1_25946", "HTA9_1_25947", "HTA9_1_25948", "HTA9_1_25949", "HTA9_1_25950", "HTA9_1_25951", "HTA9_1_25952", "HTA9_1_25953", "HTA9_1_25954", "HTA9_1_25955", "HTA9_1_25956", "HTA9_1_25957", "HTA9_1_25958", "HTA9_1_25959", "HTA9_1_25960", "HTA9_1_25961", "HTA9_1_25962", "HTA9_1_25963", "HTA9_1_25964", "HTA9_1_25965", "HTA9_1_25966", "HTA9_1_25967", "HTA9_1_25968", "HTA9_1_25969", "HTA9_1_25970", "HTA9_1_25971", "HTA9_1_25972", "HTA9_1_25973", "HTA9_1_25974", "HTA9_1_25975", "HTA9_1_25976", "HTA9_1_25977", "HTA9_1_25978", "HTA9_1_25979", "HTA9_1_25980", "HTA9_1_25981", "HTA9_1_25982", "HTA9_1_25983", "HTA9_1_25984", "HTA9_1_25985", "HTA9_1_25986", "HTA9_1_25987", "HTA9_1_25988", "HTA9_1_25989", "HTA9_1_25990", "HTA9_1_25991", "HTA9_1_25992", "HTA9_1_25993", "HTA9_1_25994", "HTA9_1_25995", "HTA9_1_25996", "HTA9_1_25997", "HTA9_1_25998", "HTA9_1_25999", "HTA9_1_26000", "HTA9_1_26001", "HTA9_1_26002", "HTA9_1_26003", "HTA9_1_26004", "HTA9_1_26005", "HTA9_1_26006", "HTA9_1_26007", "HTA9_1_26008", "HTA9_1_26009", "HTA9_1_26010", "HTA9_1_26011", "HTA9_1_26012", "HTA9_1_26013", "HTA9_1_26014", "HTA9_1_26015", "HTA9_1_26016", "HTA9_1_26017", "HTA9_1_26018", "HTA9_1_26019", "HTA9_1_26020", "HTA9_1_26021", "HTA9_1_26022", "HTA9_1_26023", "HTA9_1_26024", "HTA9_1_26025", "HTA9_1_26026", "HTA9_1_26027", "HTA9_1_26028", "HTA9_1_26029", "HTA9_1_26030", "HTA9_1_26031", "HTA9_1_26032", "HTA9_1_26033", "HTA9_1_26034", "HTA9_1_26035", "HTA9_1_26036", "HTA9_1_26037", "HTA9_1_26038", "HTA9_1_26039", "HTA9_1_26040", "HTA9_1_26041", "HTA9_1_26042", "HTA9_1_26043", "HTA9_1_26044", "HTA9_1_26045", "HTA9_1_26046", "HTA9_1_26047", "HTA9_1_26048", "HTA9_1_26049", "HTA9_1_26050", "HTA9_1_26051", "HTA9_1_26052", "HTA9_1_26053", "HTA9_1_26054", "HTA9_1_26055", "HTA9_1_26056", "HTA9_1_26057", "HTA9_1_26058", "HTA9_1_26059", "HTA9_1_26060", "HTA9_1_26061", "HTA9_1_26062", "HTA9_1_26063", "HTA9_1_26064", "HTA9_1_26065", "HTA9_1_26066", "HTA9_1_26067", "HTA9_1_26068", "HTA9_1_26069", "HTA9_1_26070", "HTA9_1_26071", "HTA9_1_26072", "HTA9_1_26073", "HTA9_1_26074", "HTA9_1_26075", "HTA9_1_26076", "HTA9_1_26077", "HTA9_1_26078", "HTA9_1_26079", "HTA9_1_26080", "HTA9_1_26081", "HTA9_1_26082", "HTA9_1_26083", "HTA9_1_26084", "HTA9_1_26085", "HTA9_1_26086", "HTA9_1_26087", "HTA9_1_26088", "HTA9_1_26089", "HTA9_1_26090", "HTA9_1_26091", "HTA9_1_26092", "HTA9_1_26093", "HTA9_1_26094", "HTA9_1_26095", "HTA9_1_26096", "HTA9_1_26097", "HTA9_1_26098", "HTA9_1_26099", "HTA9_1_26100", "HTA9_1_26101", "HTA9_1_26102", "HTA9_1_26103", "HTA9_1_26104", "HTA9_1_26105", "HTA9_1_26106", "HTA9_1_26107", "HTA9_1_26108", "HTA9_1_26109", "HTA9_1_26110", "HTA9_1_26111", "HTA9_1_26112", "HTA9_1_26113", "HTA9_1_26114", "HTA9_1_26115", "HTA9_1_26116", "HTA9_1_26117", "HTA9_1_26118", "HTA9_1_26119", "HTA9_1_26120", "HTA9_1_26121", "HTA9_1_26122", "HTA9_1_26123", "HTA9_1_26124", "HTA9_1_26125", "HTA9_1_26126", "HTA9_1_26127", "HTA9_1_26128", "HTA9_1_26129", "HTA9_1_26130", "HTA9_1_26131", "HTA9_1_26132", "HTA9_1_26133", "HTA9_1_26134", "HTA9_1_26135", "HTA9_1_26136", "HTA9_1_26137", "HTA9_1_26138", "HTA9_1_26139", "HTA9_1_26140", "HTA9_1_26141", "HTA9_1_26142", "HTA9_1_26143", "HTA9_1_26144", "HTA9_1_26145", "HTA9_1_26146", "HTA9_1_26147", "HTA9_1_26148", "HTA9_1_26149", "HTA9_1_26150", "HTA9_1_26151", "HTA9_1_26152", "HTA9_1_26153", "HTA9_1_26154", "HTA9_1_26155", "HTA9_1_26156", "HTA9_1_26157", "HTA9_1_26158", "HTA9_1_26159", "HTA9_1_26160", "HTA9_1_26161", "HTA9_1_26162", "HTA9_1_26163", "HTA9_1_26164", "HTA9_1_26165", "HTA9_1_26166", "HTA9_1_26167", "HTA9_1_26168", "HTA9_1_26169", "HTA9_1_26170", "HTA9_1_26171", "HTA9_1_26172", "HTA9_1_26173", "HTA9_1_26174", "HTA9_1_26175", "HTA9_1_26176", "HTA9_1_26177", "HTA9_1_26178", "HTA9_1_26179", "HTA9_1_26180", "HTA9_1_26181", "HTA9_1_26182", "HTA9_1_26183", "HTA9_1_26184", "HTA9_1_26185", "HTA9_1_26186", "HTA9_1_26187", "HTA9_1_26188", "HTA9_1_26189", "HTA9_1_26190", "HTA9_1_26191", "HTA9_1_26192", "HTA9_1_26193", "HTA9_1_26194", "HTA9_1_26195", "HTA9_1_26196", "HTA9_1_26197", "HTA9_1_26198", "HTA9_1_26199", "HTA9_1_26200", "HTA9_1_26201", "HTA9_1_26202", "HTA9_1_26203", "HTA9_1_26204", "HTA9_1_26205", "HTA9_1_26206", "HTA9_1_26207", "HTA9_1_26208", "HTA9_1_26209", "HTA9_1_26210", "HTA9_1_26211", "HTA9_1_26212", "HTA9_1_26213", "HTA9_1_26214", "HTA9_1_26215", "HTA9_1_26216", "HTA9_1_26217", "HTA9_1_26218", "HTA9_1_26219", "HTA9_1_26220", "HTA9_1_26221", "HTA9_1_26222", "HTA9_1_26223", "HTA9_1_26224", "HTA9_1_26225", "HTA9_1_26226", "HTA9_1_26227", "HTA9_1_26228", "HTA9_1_26229", "HTA9_1_26230", "HTA9_1_26231", "HTA9_1_26232", "HTA9_1_26233", "HTA9_1_26234", "HTA9_1_26235", "HTA9_1_26236", "HTA9_1_26237", "HTA9_1_26238", "HTA9_1_26239", "HTA9_1_26240", "HTA9_1_26241", "HTA9_1_26242", "HTA9_1_26243", "HTA9_1_26244", "HTA9_1_26245", "HTA9_1_26246", "HTA9_1_26247", "HTA9_1_26248", "HTA9_1_26249", "HTA9_1_26250", "HTA9_1_26251", "HTA9_1_26252", "HTA9_1_26253", "HTA9_1_26254", "HTA9_1_26255", "HTA9_1_26256", "HTA9_1_26257", "HTA9_1_26258", "HTA9_1_26259", "HTA9_1_26260", "HTA9_1_26261", "HTA9_1_26262", "HTA9_1_26263", "HTA9_1_26264", "HTA9_1_26265", "HTA9_1_26266", "HTA9_1_26267", "HTA9_1_26268", "HTA9_1_26269", "HTA9_1_26270", "HTA9_1_26271", "HTA9_1_26272", "HTA9_1_26273", "HTA9_1_26274", "HTA9_1_26275", "HTA9_1_26276", "HTA9_1_26277", "HTA9_1_26278", "HTA9_1_26279", "HTA9_1_26280", "HTA9_1_26281", "HTA9_1_26282", "HTA9_1_26283", "HTA9_1_26284", "HTA9_1_26285", "HTA9_1_26286", "HTA9_1_26287", "HTA9_1_26288", "HTA9_1_26289", "HTA9_1_26290", "HTA9_1_26291", "HTA9_1_26292", "HTA9_1_26293", "HTA9_1_26294", "HTA9_1_26295", "HTA9_1_26296", "HTA9_1_26297", "HTA9_1_26298", "HTA9_1_26299", "HTA9_1_26300", "HTA9_1_26301", "HTA9_1_26302", "HTA9_1_26303", "HTA9_1_26304", "HTA9_1_26305", "HTA9_1_26306", "HTA9_1_26307", "HTA9_1_26308", "HTA9_1_26309", "HTA9_1_26310", "HTA9_1_26311", "HTA9_1_26312", "HTA9_1_26313", "HTA9_1_26314", "HTA9_1_26315", "HTA9_1_26316", "HTA9_1_26317", "HTA9_1_26318", "HTA9_1_26319", "HTA9_1_26320", "HTA9_1_26321", "HTA9_1_26322", "HTA9_1_26323", "HTA9_1_26324", "HTA9_1_26325", "HTA9_1_26326", "HTA9_1_26327", "HTA9_1_26328", "HTA9_1_26329", "HTA9_1_26330", "HTA9_1_26331", "HTA9_1_26332", "HTA9_1_26333", "HTA9_1_26334", "HTA9_1_26335", "HTA9_1_26336", "HTA9_1_26337", "HTA9_1_26338", "HTA9_1_26339", "HTA9_1_26340", "HTA9_1_26341", "HTA9_1_26342", "HTA9_1_26343", "HTA9_1_26344", "HTA9_1_26345", "HTA9_1_26346", "HTA9_1_26347", "HTA9_1_26348", "HTA9_1_26349", "HTA9_1_26350", "HTA9_1_26351", "HTA9_1_26352", "HTA9_1_26353", "HTA9_1_26354", "HTA9_1_26355", "HTA9_1_26356", "HTA9_1_26357", "HTA9_1_26358", "HTA9_1_26359", "HTA9_1_26360", "HTA9_1_26361", "HTA9_1_26362", "HTA9_1_26363", "HTA9_1_26364", "HTA9_1_26365", "HTA9_1_26366", "HTA9_1_26367", "HTA9_1_26368", "HTA9_1_26369", "HTA9_1_26370", "HTA9_1_26371", "HTA9_1_26372", "HTA9_1_26373", "HTA9_1_26374", "HTA9_1_26375", "HTA9_1_26376", "HTA9_1_26377", "HTA9_1_26378", "HTA9_1_26379", "HTA9_1_26380", "HTA9_1_26381", "HTA9_1_26382", "HTA9_1_26383", "HTA9_1_26384", "HTA9_1_26385", "HTA9_1_26386", "HTA9_1_26387", "HTA9_1_26388", "HTA9_1_26389", "HTA9_1_26390", "HTA9_1_26391", "HTA9_1_26392", "HTA9_1_26393", "HTA9_1_26394", "HTA9_1_26395", "HTA9_1_26396", "HTA9_1_26397", "HTA9_1_26398", "HTA9_1_26399", "HTA9_1_26400", "HTA9_1_26401", "HTA9_1_26402", "HTA9_1_26403", "HTA9_1_26404", "HTA9_1_26405", "HTA9_1_26406", "HTA9_1_26407", "HTA9_1_26408", "HTA9_1_26409", "HTA9_1_26410", "HTA9_1_26411", "HTA9_1_26412", "HTA9_1_26413", "HTA9_1_26414", "HTA9_1_26415", "HTA9_1_26416", "HTA9_1_26417", "HTA9_1_26418", "HTA9_1_26419", "HTA9_1_26420", "HTA9_1_26421", "HTA9_1_26422", "HTA9_1_26423", "HTA9_1_26424", "HTA9_1_26425", "HTA9_1_26426", "HTA9_1_26427", "HTA9_1_26428", "HTA9_1_26429", "HTA9_1_26430", "HTA9_1_26431", "HTA9_1_26432", "HTA9_1_26433", "HTA9_1_26434", "HTA9_1_26435", "HTA9_1_26436", "HTA9_1_26437", "HTA9_1_26438", "HTA9_1_26439", "HTA9_1_26440", "HTA9_1_26441", "HTA9_1_26442", "HTA9_1_26443", "HTA9_1_26444", "HTA9_1_26445", "HTA9_1_26446", "HTA9_1_26447", "HTA9_1_26448", "HTA9_1_26449", "HTA9_1_26450", "HTA9_1_26451", "HTA9_1_26452", "HTA9_1_26453", "HTA9_1_26454", "HTA9_1_26455", "HTA9_1_26456", "HTA9_1_26457", "HTA9_1_26458", "HTA9_1_26459", "HTA9_1_26460", "HTA9_1_26461", "HTA9_1_26462", "HTA9_1_26463", "HTA9_1_26464", "HTA9_1_26465", "HTA9_1_26466", "HTA9_1_26467", "HTA9_1_26468", "HTA9_1_26469", "HTA9_1_26470", "HTA9_1_26471", "HTA9_1_26472", "HTA9_1_26473", "HTA9_1_26474", "HTA9_1_26475", "HTA9_1_26476", "HTA9_1_26477", "HTA9_1_26478", "HTA9_1_26479", "HTA9_1_26480", "HTA9_1_26481", "HTA9_1_26482", "HTA9_1_26483", "HTA9_1_26484", "HTA9_1_26485", "HTA9_1_26486", "HTA9_1_26487", "HTA9_1_26488", "HTA9_1_26489", "HTA9_1_26490", "HTA9_1_26491", "HTA9_1_26492", "HTA9_1_26493", "HTA9_1_26494", "HTA9_1_26495", "HTA9_1_26496", "HTA9_1_26497", "HTA9_1_26498", "HTA9_1_26499", "HTA9_1_26500", "HTA9_1_26501", "HTA9_1_26502", "HTA9_1_26503", "HTA9_1_26504", "HTA9_1_26505", "HTA9_1_26506", "HTA9_1_26507", "HTA9_1_26508", "HTA9_1_26509", "HTA9_1_26510", "HTA9_1_26511", "HTA9_1_26512", "HTA9_1_26513", "HTA9_1_26514", "HTA9_1_26515", "HTA9_1_26516", "HTA9_1_26517", "HTA9_1_26518", "HTA9_1_26519", "HTA9_1_26520", "HTA9_1_26521", "HTA9_1_26522", "HTA9_1_26523", "HTA9_1_26524", "HTA9_1_26525", "HTA9_1_26526", "HTA9_1_26527", "HTA9_1_26528", "HTA9_1_26529", "HTA9_1_26530", "HTA9_1_26531", "HTA9_1_26532", "HTA9_1_26533", "HTA9_1_26534", "HTA9_1_26535", "HTA9_1_26536", "HTA9_1_26537", "HTA9_1_26538", "HTA9_1_26539", "HTA9_1_26540", "HTA9_1_26541", "HTA9_1_26542", "HTA9_1_26543", "HTA9_1_26544", "HTA9_1_26545", "HTA9_1_26546", "HTA9_1_26547", "HTA9_1_26548", "HTA9_1_26549", "HTA9_1_26550", "HTA9_1_26551", "HTA9_1_26552", "HTA9_1_26553", "HTA9_1_26554", "HTA9_1_26555", "HTA9_1_26556", "HTA9_1_26557", "HTA9_1_26558", "HTA9_1_26559", "HTA9_1_26560", "HTA9_1_26561", "HTA9_1_26562", "HTA9_1_26563", "HTA9_1_26564", "HTA9_1_26565", "HTA9_1_26566", "HTA9_1_26567", "HTA9_1_26568", "HTA9_1_26569", "HTA9_1_26570", "HTA9_1_26571", "HTA9_1_26572", "HTA9_1_26573", "HTA9_1_26574", "HTA9_1_26575", "HTA9_1_26576", "HTA9_1_26577", "HTA9_1_26578", "HTA9_1_26579", "HTA9_1_26580", "HTA9_1_26581", "HTA9_1_26582", "HTA9_1_26583", "HTA9_1_26584", "HTA9_1_26585", "HTA9_1_26586", "HTA9_1_26587", "HTA9_1_26588", "HTA9_1_26589", "HTA9_1_26590", "HTA9_1_26591", "HTA9_1_26592", "HTA9_1_26593", "HTA9_1_26594", "HTA9_1_26595", "HTA9_1_26596", "HTA9_1_26597", "HTA9_1_26598", "HTA9_1_26599", "HTA9_1_26600", "HTA9_1_26601", "HTA9_1_26602", "HTA9_1_26603", "HTA9_1_26604", "HTA9_1_26605", "HTA9_1_26606", "HTA9_1_26607", "HTA9_1_26608", "HTA9_1_26609", "HTA9_1_26610", "HTA9_1_26611", "HTA9_1_26612", "HTA9_1_26613", "HTA9_1_26614", "HTA9_1_26615", "HTA9_1_26616", "HTA9_1_26617", "HTA9_1_26618", "HTA9_1_26619", "HTA9_1_26620", "HTA9_1_26621", "HTA9_1_26622", "HTA9_1_26623", "HTA9_1_26624", "HTA9_1_26625", "HTA9_1_26626", "HTA9_1_26627", "HTA9_1_26628", "HTA9_1_26629", "HTA9_1_26630", "HTA9_1_26631", "HTA9_1_26632", "HTA9_1_26633", "HTA9_1_26634", "HTA9_1_26635", "HTA9_1_26636", "HTA9_1_26637", "HTA9_1_26638", "HTA9_1_26639", "HTA9_1_26640", "HTA9_1_26641", "HTA9_1_26642", "HTA9_1_26643", "HTA9_1_26644", "HTA9_1_26645", "HTA9_1_26646", "HTA9_1_26647", "HTA9_1_26648", "HTA9_1_26649", "HTA9_1_26650", "HTA9_1_26651", "HTA9_1_26652", "HTA9_1_26653", "HTA9_1_26654", "HTA9_1_26655", "HTA9_1_26656", "HTA9_1_26657", "HTA9_1_26658", "HTA9_1_26659", "HTA9_1_26660", "HTA9_1_26661", "HTA9_1_26662", "HTA9_1_26663", "HTA9_1_26664", "HTA9_1_26665", "HTA9_1_26666", "HTA9_1_26667", "HTA9_1_26668", "HTA9_1_26669", "HTA9_1_26670", "HTA9_1_26671", "HTA9_1_26672", "HTA9_1_26673", "HTA9_1_26674", "HTA9_1_26675", "HTA9_1_26676", "HTA9_1_26677", "HTA9_1_26678", "HTA9_1_26679", "HTA9_1_26680", "HTA9_1_26681", "HTA9_1_26682", "HTA9_1_26683", "HTA9_1_26684", "HTA9_1_26685", "HTA9_1_26686", "HTA9_1_26687", "HTA9_1_26688", "HTA9_1_26689", "HTA9_1_26690", "HTA9_1_26691", "HTA9_1_26692", "HTA9_1_26693", "HTA9_1_26694", "HTA9_1_26695", "HTA9_1_26696", "HTA9_1_26697", "HTA9_1_26698", "HTA9_1_26699", "HTA9_1_26700", "HTA9_1_26701", "HTA9_1_26702", "HTA9_1_26703", "HTA9_1_26704", "HTA9_1_26705", "HTA9_1_26706", "HTA9_1_26707", "HTA9_1_26708", "HTA9_1_26709", "HTA9_1_26710", "HTA9_1_26711", "HTA9_1_26712", "HTA9_1_26713", "HTA9_1_26714", "HTA9_1_26715", "HTA9_1_26716", "HTA9_1_26717", "HTA9_1_26718", "HTA9_1_26719", "HTA9_1_26720", "HTA9_1_26721", "HTA9_1_26722", "HTA9_1_26723", "HTA9_1_26724", "HTA9_1_26725", "HTA9_1_26726", "HTA9_1_26727", "HTA9_1_26728", "HTA9_1_26729", "HTA9_1_26730", "HTA9_1_26731", "HTA9_1_26732", "HTA9_1_26733", "HTA9_1_26734", "HTA9_1_26735", "HTA9_1_26736", "HTA9_1_26737", "HTA9_1_26738", "HTA9_1_26739", "HTA9_1_26740", "HTA9_1_26741", "HTA9_1_26742", "HTA9_1_26743", "HTA9_1_26744", "HTA9_1_26745", "HTA9_1_26746", "HTA9_1_26747", "HTA9_1_26748", "HTA9_1_26749", "HTA9_1_26750", "HTA9_1_26751", "HTA9_1_26752", "HTA9_1_26753", "HTA9_1_26754", "HTA9_1_26755", "HTA9_1_26756", "HTA9_1_26757", "HTA9_1_26758", "HTA9_1_26759", "HTA9_1_26760", "HTA9_1_26761", "HTA9_1_26762", "HTA9_1_26763", "HTA9_1_26764", "HTA9_1_26765", "HTA9_1_26766", "HTA9_1_26767", "HTA9_1_26768", "HTA9_1_26769", "HTA9_1_26770", "HTA9_1_26771", "HTA9_1_26772", "HTA9_1_26773", "HTA9_1_26774", "HTA9_1_26775", "HTA9_1_26776", "HTA9_1_26777", "HTA9_1_26778", "HTA9_1_26779", "HTA9_1_26780", "HTA9_1_26781", "HTA9_1_26782", "HTA9_1_26783", "HTA9_1_26784", "HTA9_1_26785", "HTA9_1_26786", "HTA9_1_26787", "HTA9_1_26788", "HTA9_1_26789", "HTA9_1_26790", "HTA9_1_26791", "HTA9_1_26792", "HTA9_1_26793", "HTA9_1_26794", "HTA9_1_26795", "HTA9_1_26796", "HTA9_1_26797", "HTA9_1_26798", "HTA9_1_26799", "HTA9_1_26800", "HTA9_1_26801", "HTA9_1_26802", "HTA9_1_26803", "HTA9_1_26804", "HTA9_1_26805", "HTA9_1_26806", "HTA9_1_26807", "HTA9_1_26808", "HTA9_1_26809", "HTA9_1_26810", "HTA9_1_26811", "HTA9_1_26812", "HTA9_1_26813", "HTA9_1_26814", "HTA9_1_26815", "HTA9_1_26816", "HTA9_1_26817", "HTA9_1_26818", "HTA9_1_26819", "HTA9_1_26820", "HTA9_1_26821", "HTA9_1_26822", "HTA9_1_26823", "HTA9_1_26824", "HTA9_1_26825", "HTA9_1_26826", "HTA9_1_26827", "HTA9_1_26828", "HTA9_1_26829", "HTA9_1_26830", "HTA9_1_26831", "HTA9_1_26832", "HTA9_1_26833", "HTA9_1_26834", "HTA9_1_26835", "HTA9_1_26836", "HTA9_1_26837", "HTA9_1_26838", "HTA9_1_26839", "HTA9_1_26840", "HTA9_1_26841", "HTA9_1_26842", "HTA9_1_26843", "HTA9_1_26844", "HTA9_1_26845", "HTA9_1_26846", "HTA9_1_26847", "HTA9_1_26848", "HTA9_1_26849", "HTA9_1_26850", "HTA9_1_26851", "HTA9_1_26852", "HTA9_1_26853", "HTA9_1_26854", "HTA9_1_26855", "HTA9_1_26856", "HTA9_1_26857", "HTA9_1_26858", "HTA9_1_26859", "HTA9_1_26860", "HTA9_1_26861", "HTA9_1_26862", "HTA9_1_26863", "HTA9_1_26864", "HTA9_1_26865", "HTA9_1_26866", "HTA9_1_26867", "HTA9_1_26868", "HTA9_1_26869", "HTA9_1_26870", "HTA9_1_26871", "HTA9_1_26872", "HTA9_1_26873", "HTA9_1_26874", "HTA9_1_26875", "HTA9_1_26876", "HTA9_1_26877", "HTA9_1_26878", "HTA9_1_26879", "HTA9_1_26880", "HTA9_1_26881", "HTA9_1_26882", "HTA9_1_26883", "HTA9_1_26884", "HTA9_1_26885", "HTA9_1_26886", "HTA9_1_26887", "HTA9_1_26888", "HTA9_1_26889", "HTA9_1_26890", "HTA9_1_26891", "HTA9_1_26892", "HTA9_1_26893", "HTA9_1_26894", "HTA9_1_26895", "HTA9_1_26896", "HTA9_1_26897", "HTA9_1_26898", "HTA9_1_26899", "HTA9_1_26900", "HTA9_1_26901", "HTA9_1_26902", "HTA9_1_26903", "HTA9_1_26904", "HTA9_1_26905", "HTA9_1_26906", "HTA9_1_26907", "HTA9_1_26908", "HTA9_1_26909", "HTA9_1_26910", "HTA9_1_26911", "HTA9_1_26912", "HTA9_1_26913", "HTA9_1_26914", "HTA9_1_26915", "HTA9_1_26916", "HTA9_1_26917", "HTA9_1_26918", "HTA9_1_26919", "HTA9_1_26920", "HTA9_1_26921", "HTA9_1_26922", "HTA9_1_26923", "HTA9_1_26924", "HTA9_1_26925", "HTA9_1_26926", "HTA9_1_26927", "HTA9_1_26928", "HTA9_1_26929", "HTA9_1_26930", "HTA9_1_26931", "HTA9_1_26932", "HTA9_1_26933", "HTA9_1_26934", "HTA9_1_26935", "HTA9_1_26936", "HTA9_1_26937", "HTA9_1_26938", "HTA9_1_26939", "HTA9_1_26940", "HTA9_1_26941", "HTA9_1_26942", "HTA9_1_26943", "HTA9_1_26944", "HTA9_1_26945", "HTA9_1_26946", "HTA9_1_26947", "HTA9_1_26948", "HTA9_1_26949", "HTA9_1_26950", "HTA9_1_26951", "HTA9_1_26952", "HTA9_1_26953", "HTA9_1_26954", "HTA9_1_26955", "HTA9_1_26956", "HTA9_1_26957", "HTA9_1_26958", "HTA9_1_26959", "HTA9_1_26960", "HTA9_1_26961", "HTA9_1_26962", "HTA9_1_26963", "HTA9_1_26964", "HTA9_1_26965", "HTA9_1_26966", "HTA9_1_26967", "HTA9_1_26968", "HTA9_1_26969", "HTA9_1_26970", "HTA9_1_26971", "HTA9_1_26972", "HTA9_1_26973", "HTA9_1_26974", "HTA9_1_26975", "HTA9_1_26976", "HTA9_1_26977", "HTA9_1_26978", "HTA9_1_26979", "HTA9_1_26980", "HTA9_1_26981", "HTA9_1_26982", "HTA9_1_26983", "HTA9_1_26984", "HTA9_1_26985", "HTA9_1_26986", "HTA9_1_26987", "HTA9_1_26988", "HTA9_1_26989", "HTA9_1_26990", "HTA9_1_26991", "HTA9_1_26992", "HTA9_1_26993", "HTA9_1_26994", "HTA9_1_26995", "HTA9_1_26996", "HTA9_1_26997", "HTA9_1_26998", "HTA9_1_26999", "HTA9_1_27000", "HTA9_1_27001", "HTA9_1_27002", "HTA9_1_27003", "HTA9_1_27004", "HTA9_1_27005", "HTA9_1_27006", "HTA9_1_27007", "HTA9_1_27008", "HTA9_1_27009", "HTA9_1_27010", "HTA9_1_27011", "HTA9_1_27012", "HTA9_1_27013", "HTA9_1_27014", "HTA9_1_27015", "HTA9_1_27016", "HTA9_1_27017", "HTA9_1_27018", "HTA9_1_27019", "HTA9_1_27020", "HTA9_1_27021", "HTA9_1_27022", "HTA9_1_27023", "HTA9_1_27024", "HTA9_1_27025", "HTA9_1_27026", "HTA9_1_27027", "HTA9_1_27028", "HTA9_1_27029", "HTA9_1_27030", "HTA9_1_27031", "HTA9_1_27032", "HTA9_1_27033", "HTA9_1_27034", "HTA9_1_27035", "HTA9_1_27036", "HTA9_1_27037", "HTA9_1_27038", "HTA9_1_27039", "HTA9_1_27040", "HTA9_1_27041", "HTA9_1_27042", "HTA9_1_27043", "HTA9_1_27044", "HTA9_1_27045", "HTA9_1_27046", "HTA9_1_27047", "HTA9_1_27048", "HTA9_1_27049", "HTA9_1_27050", "HTA9_1_27051", "HTA9_1_27052", "HTA9_1_27053", "HTA9_1_27054", "HTA9_1_27055", "HTA9_1_27056", "HTA9_1_27057", "HTA9_1_27058", "HTA9_1_27059", "HTA9_1_27060", "HTA9_1_27061", "HTA9_1_27062", "HTA9_1_27063", "HTA9_1_27064", "HTA9_1_27065", "HTA9_1_27066", "HTA9_1_27067", "HTA9_1_27068", "HTA9_1_27069", "HTA9_1_27070", "HTA9_1_27071", "HTA9_1_27072", "HTA9_1_27073", "HTA9_1_27074", "HTA9_1_27075", "HTA9_1_27076", "HTA9_1_27077", "HTA9_1_27078", "HTA9_1_27079", "HTA9_1_27080", "HTA9_1_27081", "HTA9_1_27082", "HTA9_1_27083", "HTA9_1_27084", "HTA9_1_27085", "HTA9_1_27086", "HTA9_1_27087", "HTA9_1_27088", "HTA9_1_27089", "HTA9_1_27090", "HTA9_1_27091", "HTA9_1_27092", "HTA9_1_27093", "HTA9_1_27094", "HTA9_1_27095", "HTA9_1_27096", "HTA9_1_27097", "HTA9_1_27098", "HTA9_1_27099", "HTA9_1_27100", "HTA9_1_27101", "HTA9_1_27102", "HTA9_1_27103", "HTA9_1_27104", "HTA9_1_27105", "HTA9_1_27106", "HTA9_1_27107", "HTA9_1_27108", "HTA9_1_27109", "HTA9_1_27110", "HTA9_1_27111", "HTA9_1_27112", "HTA9_1_27113", "HTA9_1_27114", "HTA9_1_27115", "HTA9_1_27116", "HTA9_1_27117", "HTA9_1_27118", "HTA9_1_27119", "HTA9_1_27120", "HTA9_1_27121", "HTA9_1_27122", "HTA9_1_27123", "HTA9_1_27124", "HTA9_1_27125", "HTA9_1_27126", "HTA9_1_27127", "HTA9_1_27128", "HTA9_1_27129", "HTA9_1_27130", "HTA9_1_27131", "HTA9_1_27132", "HTA9_1_27133", "HTA9_1_27134", "HTA9_1_27135", "HTA9_1_27136", "HTA9_1_27137", "HTA9_1_27138", "HTA9_1_27139", "HTA9_1_27140", "HTA9_1_27141", "HTA9_1_27142", "HTA9_1_27143", "HTA9_1_27144", "HTA9_1_27145", "HTA9_1_27146", "HTA9_1_27147", "HTA9_1_27148", "HTA9_1_27149", "HTA9_1_27150", "HTA9_1_27151", "HTA9_1_27152", "HTA9_1_27153", "HTA9_1_27154", "HTA9_1_27155", "HTA9_1_27156", "HTA9_1_27157", "HTA9_1_27158", "HTA9_1_27159", "HTA9_1_27160", "HTA9_1_27161", "HTA9_1_27162", "HTA9_1_27163", "HTA9_1_27164", "HTA9_1_27165", "HTA9_1_27166", "HTA9_1_27167", "HTA9_1_27168", "HTA9_1_27169", "HTA9_1_27170", "HTA9_1_27171", "HTA9_1_27172", "HTA9_1_27173", "HTA9_1_27174", "HTA9_1_27175", "HTA9_1_27176", "HTA9_1_27177", "HTA9_1_27178", "HTA9_1_27179", "HTA9_1_27180", "HTA9_1_27181", "HTA9_1_27182", "HTA9_1_27183", "HTA9_1_27184", "HTA9_1_27185", "HTA9_1_27186", "HTA9_1_27187", "HTA9_1_27188", "HTA9_1_27189", "HTA9_1_27190", "HTA9_1_27191", "HTA9_1_27192", "HTA9_1_27193", "HTA9_1_27194", "HTA9_1_27195", "HTA9_1_27196", "HTA9_1_27197", "HTA9_1_27198", "HTA9_1_27199", "HTA9_1_27200", "HTA9_1_27201", "HTA9_1_27202", "HTA9_1_27203", "HTA9_1_27204", "HTA9_1_27205", "HTA9_1_27206", "HTA9_1_27207", "HTA9_1_27208", "HTA9_1_27209", "HTA9_1_27210", "HTA9_1_27211", "HTA9_1_27212", "HTA9_1_27213", "HTA9_1_27214", "HTA9_1_27215", "HTA9_1_27216", "HTA9_1_27217", "HTA9_1_27218", "HTA9_1_27219", "HTA9_1_27220", "HTA9_1_27221", "HTA9_1_27222", "HTA9_1_27223", "HTA9_1_27224", "HTA9_1_27225", "HTA9_1_27226", "HTA9_1_27227", "HTA9_1_27228", "HTA9_1_27229", "HTA9_1_27230", "HTA9_1_27231", "HTA9_1_27232", "HTA9_1_27233", "HTA9_1_27234", "HTA9_1_27235", "HTA9_1_27236", "HTA9_1_27237", "HTA9_1_27238", "HTA9_1_27239", "HTA9_1_27240", "HTA9_1_27241", "HTA9_1_27242", "HTA9_1_27243", "HTA9_1_27244", "HTA9_1_27245", "HTA9_1_27246", "HTA9_1_27247", "HTA9_1_27248", "HTA9_1_27249", "HTA9_1_27250", "HTA9_1_27251", "HTA9_1_27252", "HTA9_1_27253", "HTA9_1_27254", "HTA9_1_27255", "HTA9_1_27256", "HTA9_1_27257", "HTA9_1_27258", "HTA9_1_27259", "HTA9_1_27260", "HTA9_1_27261", "HTA9_1_27262", "HTA9_1_27263", "HTA9_1_27264", "HTA9_1_27265", "HTA9_1_27266", "HTA9_1_27267", "HTA9_1_27268", "HTA9_1_27269", "HTA9_1_27270", "HTA9_1_27271", "HTA9_1_27272", "HTA9_1_27273", "HTA9_1_27274", "HTA9_1_27275", "HTA9_1_27276", "HTA9_1_27277", "HTA9_1_27278", "HTA9_1_27279", "HTA9_1_27280", "HTA9_1_27281", "HTA9_1_27282", "HTA9_1_27283", "HTA9_1_27284", "HTA9_1_27285", "HTA9_1_27286", "HTA9_1_27287", "HTA9_1_27288", "HTA9_1_27289", "HTA9_1_27290", "HTA9_1_27291", "HTA9_1_27292", "HTA9_1_27293", "HTA9_1_27294", "HTA9_1_27295", "HTA9_1_27296", "HTA9_1_27297", "HTA9_1_27298", "HTA9_1_27299", "HTA9_1_27300", "HTA9_1_27301", "HTA9_1_27302", "HTA9_1_27303", "HTA9_1_27304", "HTA9_1_27305", "HTA9_1_27306", "HTA9_1_27307", "HTA9_1_27308", "HTA9_1_27309", "HTA9_1_27310", "HTA9_1_27311", "HTA9_1_27312", "HTA9_1_27313", "HTA9_1_27314", "HTA9_1_27315", "HTA9_1_27316", "HTA9_1_27317", "HTA9_1_27318", "HTA9_1_27319", "HTA9_1_27320", "HTA9_1_27321", "HTA9_1_27322", "HTA9_1_27323", "HTA9_1_27324", "HTA9_1_27325", "HTA9_1_27326", "HTA9_1_27327", "HTA9_1_27328", "HTA9_1_27329", "HTA9_1_27330", "HTA9_1_27331", "HTA9_1_27332", "HTA9_1_27333", "HTA9_1_27334", "HTA9_1_27335", "HTA9_1_27336", "HTA9_1_27337", "HTA9_1_27338", "HTA9_1_27339", "HTA9_1_27340", "HTA9_1_27341", "HTA9_1_27342", "HTA9_1_27343", "HTA9_1_27344", "HTA9_1_27345", "HTA9_1_27346", "HTA9_1_27347", "HTA9_1_27348", "HTA9_1_27349", "HTA9_1_27350", "HTA9_1_27351", "HTA9_1_27352", "HTA9_1_27353", "HTA9_1_27354", "HTA9_1_27355", "HTA9_1_27356", "HTA9_1_27357", "HTA9_1_27358", "HTA9_1_27359", "HTA9_1_27360", "HTA9_1_27361", "HTA9_1_27362", "HTA9_1_27363", "HTA9_1_27364", "HTA9_1_27365", "HTA9_1_27366", "HTA9_1_27367", "HTA9_1_27368", "HTA9_1_27369", "HTA9_1_27370", "HTA9_1_27371", "HTA9_1_27372", "HTA9_1_27373", "HTA9_1_27374", "HTA9_1_27375", "HTA9_1_27376", "HTA9_1_27377", "HTA9_1_27378", "HTA9_1_27379", "HTA9_1_27380", "HTA9_1_27381", "HTA9_1_27382", "HTA9_1_27383", "HTA9_1_27384", "HTA9_1_27385", "HTA9_1_27386", "HTA9_1_27387", "HTA9_1_27388", "HTA9_1_27389", "HTA9_1_27390", "HTA9_1_27391", "HTA9_1_27392", "HTA9_1_27393", "HTA9_1_27394", "HTA9_1_27395", "HTA9_1_27396", "HTA9_1_27397", "HTA9_1_27398", "HTA9_1_27399", "HTA9_1_27400", "HTA9_1_27401", "HTA9_1_27402", "HTA9_1_27403", "HTA9_1_27404", "HTA9_1_27405", "HTA9_1_27406", "HTA9_1_27407", "HTA9_1_27408", "HTA9_1_27409", "HTA9_1_27410", "HTA9_1_27411", "HTA9_1_27412", "HTA9_1_27413", "HTA9_1_27414", "HTA9_1_27415", "HTA9_1_27416", "HTA9_1_27417", "HTA9_1_27418", "HTA9_1_27419", "HTA9_1_27420", "HTA9_1_27421", "HTA9_1_27422", "HTA9_1_27423", "HTA9_1_27424", "HTA9_1_27425", "HTA9_1_27426", "HTA9_1_27427", "HTA9_1_27428", "HTA9_1_27429", "HTA9_1_27430", "HTA9_1_27431", "HTA9_1_27432", "HTA9_1_27433", "HTA9_1_27434", "HTA9_1_27435", "HTA9_1_27436", "HTA9_1_27437", "HTA9_1_27438", "HTA9_1_27439", "HTA9_1_27440", "HTA9_1_27441", "HTA9_1_27442", "HTA9_1_27443", "HTA9_1_27444", "HTA9_1_27445", "HTA9_1_27446", "HTA9_1_27447", "HTA9_1_27448", "HTA9_1_27449", "HTA9_1_27450", "HTA9_1_27451", "HTA9_1_27452", "HTA9_1_27453", "HTA9_1_27454", "HTA9_1_27455", "HTA9_1_27456", "HTA9_1_27457", "HTA9_1_27458", "HTA9_1_27459", "HTA9_1_27460", "HTA9_1_27461", "HTA9_1_27462", "HTA9_1_27463", "HTA9_1_27464", "HTA9_1_27465", "HTA9_1_27466", "HTA9_1_27467", "HTA9_1_27468", "HTA9_1_27469", "HTA9_1_27470", "HTA9_1_27471", "HTA9_1_27472", "HTA9_1_27473", "HTA9_1_27474", "HTA9_1_27475", "HTA9_1_27476", "HTA9_1_27477", "HTA9_1_27478", "HTA9_1_27479", "HTA9_1_27480", "HTA9_1_27481", "HTA9_1_27482", "HTA9_1_27483", "HTA9_1_27484", "HTA9_1_27485", "HTA9_1_27486", "HTA9_1_27487", "HTA9_1_27488", "HTA9_1_27489", "HTA9_1_27490", "HTA9_1_27491", "HTA9_1_27492", "HTA9_1_27493", "HTA9_1_27494", "HTA9_1_27495", "HTA9_1_27496", "HTA9_1_27497", "HTA9_1_27498", "HTA9_1_27499", "HTA9_1_27500", "HTA9_1_27501", "HTA9_1_27502", "HTA9_1_27503", "HTA9_1_27504", "HTA9_1_27505", "HTA9_1_27506", "HTA9_1_27507", "HTA9_1_27508", "HTA9_1_27509", "HTA9_1_27510", "HTA9_1_27511", "HTA9_1_27512", "HTA9_1_27513", "HTA9_1_27514", "HTA9_1_27515", "HTA9_1_27516", "HTA9_1_27517", "HTA9_1_27518", "HTA9_1_27519", "HTA9_1_27520", "HTA9_1_27521", "HTA9_1_27522", "HTA9_1_27523", "HTA9_1_27524", "HTA9_1_27525", "HTA9_1_27526", "HTA9_1_27527", "HTA9_1_27528", "HTA9_1_27529", "HTA9_1_27530", "HTA9_1_27531", "HTA9_1_27532", "HTA9_1_27533", "HTA9_1_27534", "HTA9_1_27535", "HTA9_1_27536", "HTA9_1_27537", "HTA9_1_27538", "HTA9_1_27539", "HTA9_1_27540", "HTA9_1_27541", "HTA9_1_27542", "HTA9_1_27543", "HTA9_1_27544", "HTA9_1_27545", "HTA9_1_27546", "HTA9_1_27547", "HTA9_1_27548", "HTA9_1_27549", "HTA9_1_27550", "HTA9_1_27551", "HTA9_1_27552", "HTA9_1_27553", "HTA9_1_27554", "HTA9_1_27555", "HTA9_1_27556", "HTA9_1_27557", "HTA9_1_27558", "HTA9_1_27559", "HTA9_1_27560", "HTA9_1_27561", "HTA9_1_27562", "HTA9_1_27563", "HTA9_1_27564", "HTA9_1_27565", "HTA9_1_27566", "HTA9_1_27567", "HTA9_1_27568", "HTA9_1_27569", "HTA9_1_27570", "HTA9_1_27571", "HTA9_1_27572", "HTA9_1_27573", "HTA9_1_27574", "HTA9_1_27575", "HTA9_1_27576", "HTA9_1_27577", "HTA9_1_27578", "HTA9_1_27579", "HTA9_1_27580", "HTA9_1_27581", "HTA9_1_27582", "HTA9_1_27583", "HTA9_1_27584", "HTA9_1_27585", "HTA9_1_27586", "HTA9_1_27587", "HTA9_1_27588", "HTA9_1_27589", "HTA9_1_27590", "HTA9_1_27591", "HTA9_1_27592", "HTA9_1_27593", "HTA9_1_27594", "HTA9_1_27595", "HTA9_1_27596", "HTA9_1_27597", "HTA9_1_27598", "HTA9_1_27599", "HTA9_1_27600", "HTA9_1_27601", "HTA9_1_27602", "HTA9_1_27603", "HTA9_1_27604", "HTA9_1_27605", "HTA9_1_27606", "HTA9_1_27607", "HTA9_1_27608", "HTA9_1_27609", "HTA9_1_27610", "HTA9_1_27611", "HTA9_1_27612", "HTA9_1_27613", "HTA9_1_27614", "HTA9_1_27615", "HTA9_1_27616", "HTA9_1_27617", "HTA9_1_27618", "HTA9_1_27619", "HTA9_1_27620", "HTA9_1_27621", "HTA9_1_27622", "HTA9_1_27623", "HTA9_1_27624", "HTA9_1_27625", "HTA9_1_27626", "HTA9_1_27627", "HTA9_1_27628", "HTA9_1_27629", "HTA9_1_27630", "HTA9_1_27631", "HTA9_1_27632", "HTA9_1_27633", "HTA9_1_27634", "HTA9_1_27635", "HTA9_1_27636", "HTA9_1_27637", "HTA9_1_27638", "HTA9_1_27639", "HTA9_1_27640", "HTA9_1_27641", "HTA9_1_27642", "HTA9_1_27643", "HTA9_1_27644", "HTA9_1_27645", "HTA9_1_27646", "HTA9_1_27647", "HTA9_1_27648", "HTA9_1_27649", "HTA9_1_27650", "HTA9_1_27651", "HTA9_1_27652", "HTA9_1_27653", "HTA9_1_27654", "HTA9_1_27655", "HTA9_1_27656", "HTA9_1_27657", "HTA9_1_27658", "HTA9_1_27659", "HTA9_1_27660", "HTA9_1_27661", "HTA9_1_27662", "HTA9_1_27663", "HTA9_1_27664", "HTA9_1_27665", "HTA9_1_27666", "HTA9_1_27667", "HTA9_1_27668", "HTA9_1_27669", "HTA9_1_27670", "HTA9_1_27671", "HTA9_1_27672", "HTA9_1_27673", "HTA9_1_27674", "HTA9_1_27675", "HTA9_1_27676", "HTA9_1_27677", "HTA9_1_27678", "HTA9_1_27679", "HTA9_1_27680", "HTA9_1_27681", "HTA9_1_27682", "HTA9_1_27683", "HTA9_1_27684", "HTA9_1_27685", "HTA9_1_27686", "HTA9_1_27687", "HTA9_1_27688", "HTA9_1_27689", "HTA9_1_27690", "HTA9_1_27691", "HTA9_1_27692", "HTA9_1_27693", "HTA9_1_27694", "HTA9_1_27695", "HTA9_1_27696", "HTA9_1_27697", "HTA9_1_27698", "HTA9_1_27699", "HTA9_1_27700", "HTA9_1_27701", "HTA9_1_27702", "HTA9_1_27703", "HTA9_1_27704", "HTA9_1_27705", "HTA9_1_27706", "HTA9_1_27707", "HTA9_1_27708", "HTA9_1_27709", "HTA9_1_27710", "HTA9_1_27711", "HTA9_1_27712", "HTA9_1_27713", "HTA9_1_27714", "HTA9_1_27715", "HTA9_1_27716", "HTA9_1_27717", "HTA9_1_27718", "HTA9_1_27719", "HTA9_1_27720", "HTA9_1_27721", "HTA9_1_27722", "HTA9_1_27723", "HTA9_1_27724", "HTA9_1_27725", "HTA9_1_27726", "HTA9_1_27727", "HTA9_1_27728", "HTA9_1_27729", "HTA9_1_27730", "HTA9_1_27731", "HTA9_1_27732", "HTA9_1_27733", "HTA9_1_27734", "HTA9_1_27735", "HTA9_1_27736", "HTA9_1_27737", "HTA9_1_27738", "HTA9_1_27739", "HTA9_1_27740", "HTA9_1_27741", "HTA9_1_27742", "HTA9_1_27743", "HTA9_1_27744", "HTA9_1_27745", "HTA9_1_27746", "HTA9_1_27747", "HTA9_1_27748", "HTA9_1_27749", "HTA9_1_27750", "HTA9_1_27751", "HTA9_1_27752", "HTA9_1_27753", "HTA9_1_27754", "HTA9_1_27755", "HTA9_1_27756", "HTA9_1_27757", "HTA9_1_27758", "HTA9_1_27759", "HTA9_1_27760", "HTA9_1_27761", "HTA9_1_27762", "HTA9_1_27763", "HTA9_1_27764", "HTA9_1_27765", "HTA9_1_27766", "HTA9_1_27767", "HTA9_1_27768", "HTA9_1_27769", "HTA9_1_27770", "HTA9_1_27771", "HTA9_1_27772", "HTA9_1_27773", "HTA9_1_27774", "HTA9_1_27775", "HTA9_1_27776", "HTA9_1_27777", "HTA9_1_27778", "HTA9_1_27779", "HTA9_1_27780", "HTA9_1_27781", "HTA9_1_27782", "HTA9_1_27783", "HTA9_1_27784", "HTA9_1_27785", "HTA9_1_27786", "HTA9_1_27787", "HTA9_1_27788", "HTA9_1_27789", "HTA9_1_27790", "HTA9_1_27791", "HTA9_1_27792", "HTA9_1_27793", "HTA9_1_27794", "HTA9_1_27795", "HTA9_1_27796", "HTA9_1_27797", "HTA9_1_27798", "HTA9_1_27799", "HTA9_1_27800", "HTA9_1_27801", "HTA9_1_27802", "HTA9_1_27803", "HTA9_1_27804", "HTA9_1_27805", "HTA9_1_27806", "HTA9_1_27807", "HTA9_1_27808", "HTA9_1_27809", "HTA9_1_27810", "HTA9_1_27811", "HTA9_1_27812", "HTA9_1_27813", "HTA9_1_27814", "HTA9_1_27815", "HTA9_1_27816", "HTA9_1_27817", "HTA9_1_27818", "HTA9_1_27819", "HTA9_1_27820", "HTA9_1_27821", "HTA9_1_27822", "HTA9_1_27823", "HTA9_1_27824", "HTA9_1_27825", "HTA9_1_27826", "HTA9_1_27827", "HTA9_1_27828", "HTA9_1_27829", "HTA9_1_27830", "HTA9_1_27831", "HTA9_1_27832", "HTA9_1_27833", "HTA9_1_27834", "HTA9_1_27835", "HTA9_1_27836", "HTA9_1_27837", "HTA9_1_27838", "HTA9_1_27839", "HTA9_1_27840", "HTA9_1_27841", "HTA9_1_27842", "HTA9_1_27843", "HTA9_1_27844", "HTA9_1_27845", "HTA9_1_27846", "HTA9_1_27847", "HTA9_1_27848", "HTA9_1_27849", "HTA9_1_27850", "HTA9_1_27851", "HTA9_1_27852", "HTA9_1_27853", "HTA9_1_27854", "HTA9_1_27855", "HTA9_1_27856", "HTA9_1_27857", "HTA9_1_27858", "HTA9_1_27859", "HTA9_1_27860", "HTA9_1_27861", "HTA9_1_27862", "HTA9_1_27863", "HTA9_1_27864", "HTA9_1_27865", "HTA9_1_27866", "HTA9_1_27867", "HTA9_1_27868", "HTA9_1_27869", "HTA9_1_27870", "HTA9_1_27871", "HTA9_1_27872", "HTA9_1_27873", "HTA9_1_27874", "HTA9_1_27875", "HTA9_1_27876", "HTA9_1_27877", "HTA9_1_27878", "HTA9_1_27879", "HTA9_1_27880", "HTA9_1_27881", "HTA9_1_27882", "HTA9_1_27883", "HTA9_1_27884", "HTA9_1_27885", "HTA9_1_27886", "HTA9_1_27887", "HTA9_1_27888", "HTA9_1_27889", "HTA9_1_27890", "HTA9_1_27891", "HTA9_1_27892", "HTA9_1_27893", "HTA9_1_27894", "HTA9_1_27895", "HTA9_1_27896", "HTA9_1_27897", "HTA9_1_27898", "HTA9_1_27899", "HTA9_1_27900", "HTA9_1_27901", "HTA9_1_27902", "HTA9_1_27903", "HTA9_1_27904", "HTA9_1_27905", "HTA9_1_27906", "HTA9_1_27907", "HTA9_1_27908", "HTA9_1_27909", "HTA9_1_27910", "HTA9_1_27911", "HTA9_1_27912", "HTA9_1_27913", "HTA9_1_27914", "HTA9_1_27915", "HTA9_1_27916", "HTA9_1_27917", "HTA9_1_27918", "HTA9_1_27919", "HTA9_1_27920", "HTA9_1_27921", "HTA9_1_27922", "HTA9_1_27923", "HTA9_1_27924", "HTA9_1_27925", "HTA9_1_27926", "HTA9_1_27927", "HTA9_1_27928", "HTA9_1_27929", "HTA9_1_27930", "HTA9_1_27931", "HTA9_1_27932", "HTA9_1_27933", "HTA9_1_27934", "HTA9_1_27935", "HTA9_1_27936", "HTA9_1_27937", "HTA9_1_27938", "HTA9_1_27939", "HTA9_1_27940", "HTA9_1_27941", "HTA9_1_27942", "HTA9_1_27943", "HTA9_1_27944", "HTA9_1_27945", "HTA9_1_27946", "HTA9_1_27947", "HTA9_1_27948", "HTA9_1_27949", "HTA9_1_27950", "HTA9_1_27951", "HTA9_1_27952", "HTA9_1_27953", "HTA9_1_27954", "HTA9_1_27955", "HTA9_1_27956", "HTA9_1_27957", "HTA9_1_27958", "HTA9_1_27959", "HTA9_1_27960", "HTA9_1_27961", "HTA9_1_27962", "HTA9_1_27963", "HTA9_1_27964", "HTA9_1_27965", "HTA9_1_27966", "HTA9_1_27967", "HTA9_1_27968", "HTA9_1_27969", "HTA9_1_27970", "HTA9_1_27971", "HTA9_1_27972", "HTA9_1_27973", "HTA9_1_27974", "HTA9_1_27975", "HTA9_1_27976", "HTA9_1_27977", "HTA9_1_27978", "HTA9_1_27979", "HTA9_1_27980", "HTA9_1_27981", "HTA9_1_27982", "HTA9_1_27983", "HTA9_1_27984", "HTA9_1_27985", "HTA9_1_27986", "HTA9_1_27987", "HTA9_1_27988", "HTA9_1_27989", "HTA9_1_27990", "HTA9_1_27991", "HTA9_1_27992", "HTA9_1_27993", "HTA9_1_27994", "HTA9_1_27995", "HTA9_1_27996", "HTA9_1_27997", "HTA9_1_27998", "HTA9_1_27999", "HTA9_1_28000", "HTA9_1_28001", "HTA9_1_28002", "HTA9_1_28003", "HTA9_1_28004", "HTA9_1_28005", "HTA9_1_28006", "HTA9_1_28007", "HTA9_1_28008", "HTA9_1_28009", "HTA9_1_28010", "HTA9_1_28011", "HTA9_1_28012", "HTA9_1_28013", "HTA9_1_28014", "HTA9_1_28015", "HTA9_1_28016", "HTA9_1_28017", "HTA9_1_28018", "HTA9_1_28019", "HTA9_1_28020", "HTA9_1_28021", "HTA9_1_28022", "HTA9_1_28023", "HTA9_1_28024", "HTA9_1_28025", "HTA9_1_28026", "HTA9_1_28027", "HTA9_1_28028", "HTA9_1_28029", "HTA9_1_28030", "HTA9_1_28031", "HTA9_1_28032", "HTA9_1_28033", "HTA9_1_28034", "HTA9_1_28035", "HTA9_1_28036", "HTA9_1_28037", "HTA9_1_28038", "HTA9_1_28039", "HTA9_1_28040", "HTA9_1_28041", "HTA9_1_28042", "HTA9_1_28043", "HTA9_1_28044", "HTA9_1_28045", "HTA9_1_28046", "HTA9_1_28047", "HTA9_1_28048", "HTA9_1_28049", "HTA9_1_28050", "HTA9_1_28051", "HTA9_1_28052", "HTA9_1_28053", "HTA9_1_28054", "HTA9_1_28055", "HTA9_1_28056", "HTA9_1_28057", "HTA9_1_28058", "HTA9_1_28059", "HTA9_1_28060", "HTA9_1_28061", "HTA9_1_28062", "HTA9_1_28063", "HTA9_1_28064", "HTA9_1_28065", "HTA9_1_28066", "HTA9_1_28067", "HTA9_1_28068", "HTA9_1_28069", "HTA9_1_28070", "HTA9_1_28071", "HTA9_1_28072", "HTA9_1_28073", "HTA9_1_28074", "HTA9_1_28075", "HTA9_1_28076", "HTA9_1_28077", "HTA9_1_28078", "HTA9_1_28079", "HTA9_1_28080", "HTA9_1_28081", "HTA9_1_28082", "HTA9_1_28083", "HTA9_1_28084", "HTA9_1_28085", "HTA9_1_28086", "HTA9_1_28087", "HTA9_1_28088", "HTA9_1_28089", "HTA9_1_28090", "HTA9_1_28091", "HTA9_1_28092", "HTA9_1_28093", "HTA9_1_28094", "HTA9_1_28095", "HTA9_1_28096", "HTA9_1_28097", "HTA9_1_28098", "HTA9_1_28099", "HTA9_1_28100", "HTA9_1_28101", "HTA9_1_28102", "HTA9_1_28103", "HTA9_1_28104", "HTA9_1_28105", "HTA9_1_28106", "HTA9_1_28107", "HTA9_1_28108", "HTA9_1_28109", "HTA9_1_28110", "HTA9_1_28111", "HTA9_1_28112", "HTA9_1_28113", "HTA9_1_28114", "HTA9_1_28115", "HTA9_1_28116", "HTA9_1_28117", "HTA9_1_28118", "HTA9_1_28119", "HTA9_1_28120", "HTA9_1_28121", "HTA9_1_28122", "HTA9_1_28123", "HTA9_1_28124", "HTA9_1_28125", "HTA9_1_28126", "HTA9_1_28127", "HTA9_1_28128", "HTA9_1_28129", "HTA9_1_28130", "HTA9_1_28131", "HTA9_1_28132", "HTA9_1_28133", "HTA9_1_28134", "HTA9_1_28135", "HTA9_1_28136", "HTA9_1_28137", "HTA9_1_28138", "HTA9_1_28139", "HTA9_1_28140", "HTA9_1_28141", "HTA9_1_28142", "HTA9_1_28143", "HTA9_1_28144", "HTA9_1_28145", "HTA9_1_28146", "HTA9_1_28147", "HTA9_1_28148", "HTA9_1_28149", "HTA9_1_28150", "HTA9_1_28151", "HTA9_1_28152", "HTA9_1_28153", "HTA9_1_28154", "HTA9_1_28155", "HTA9_1_28156", "HTA9_1_28157", "HTA9_1_28158", "HTA9_1_28159", "HTA9_1_28160", "HTA9_1_28161", "HTA9_1_28162", "HTA9_1_28163", "HTA9_1_28164", "HTA9_1_28165", "HTA9_1_28166", "HTA9_1_28167", "HTA9_1_28168", "HTA9_1_28169", "HTA9_1_28170", "HTA9_1_28171", "HTA9_1_28172", "HTA9_1_28173", "HTA9_1_28174", "HTA9_1_28175", "HTA9_1_28176", "HTA9_1_28177", "HTA9_1_28178", "HTA9_1_28179", "HTA9_1_28180", "HTA9_1_28181", "HTA9_1_28182", "HTA9_1_28183", "HTA9_1_28184", "HTA9_1_28185", "HTA9_1_28186", "HTA9_1_28187", "HTA9_1_28188", "HTA9_1_28189", "HTA9_1_28190", "HTA9_1_28191", "HTA9_1_28192", "HTA9_1_28193", "HTA9_1_28194", "HTA9_1_28195", "HTA9_1_28196", "HTA9_1_28197", "HTA9_1_28198", "HTA9_1_28199", "HTA9_1_28200", "HTA9_1_28201", "HTA9_1_28202", "HTA9_1_28203", "HTA9_1_28204", "HTA9_1_28205", "HTA9_1_28206", "HTA9_1_28207", "HTA9_1_28208", "HTA9_1_28209", "HTA9_1_28210", "HTA9_1_28211", "HTA9_1_28212", "HTA9_1_28213", "HTA9_1_28214", "HTA9_1_28215", "HTA9_1_28216", "HTA9_1_28217", "HTA9_1_28218", "HTA9_1_28219", "HTA9_1_28220", "HTA9_1_28221", "HTA9_1_28222", "HTA9_1_28223", "HTA9_1_28224", "HTA9_1_28225", "HTA9_1_28226", "HTA9_1_28227", "HTA9_1_28228", "HTA9_1_28229", "HTA9_1_28230", "HTA9_1_28231", "HTA9_1_28232", "HTA9_1_28233", "HTA9_1_28234", "HTA9_1_28235", "HTA9_1_28236", "HTA9_1_28237", "HTA9_1_28238", "HTA9_1_28239", "HTA9_1_28240", "HTA9_1_28241", "HTA9_1_28242", "HTA9_1_28243", "HTA9_1_28244", "HTA9_1_28245", "HTA9_1_28246", "HTA9_1_28247", "HTA9_1_28248", "HTA9_1_28249", "HTA9_1_28250", "HTA9_1_28251", "HTA9_1_28252", "HTA9_1_28253", "HTA9_1_28254", "HTA9_1_28255", "HTA9_1_28256", "HTA9_1_28257", "HTA9_1_28258", "HTA9_1_28259", "HTA9_1_28260", "HTA9_1_28261", "HTA9_1_28262", "HTA9_1_28263", "HTA9_1_28264", "HTA9_1_28265", "HTA9_1_28266", "HTA9_1_28267", "HTA9_1_28268", "HTA9_1_28269", "HTA9_1_28270", "HTA9_1_28271", "HTA9_1_28272", "HTA9_1_28273", "HTA9_1_28274", "HTA9_1_28275", "HTA9_1_28276", "HTA9_1_28277", "HTA9_1_28278", "HTA9_1_28279", "HTA9_1_28280", "HTA9_1_28281", "HTA9_1_28282", "HTA9_1_28283", "HTA9_1_28284", "HTA9_1_28285", "HTA9_1_28286", "HTA9_1_28287", "HTA9_1_28288", "HTA9_1_28289", "HTA9_1_28290", "HTA9_1_28291", "HTA9_1_28292", "HTA9_1_28293", "HTA9_1_28294", "HTA9_1_28295", "HTA9_1_28296", "HTA9_1_28297", "HTA9_1_28298", "HTA9_1_28299", "HTA9_1_28300", "HTA9_1_28301", "HTA9_1_28302", "HTA9_1_28303", "HTA9_1_28304", "HTA9_1_28305", "HTA9_1_28306", "HTA9_1_28307", "HTA9_1_28308", "HTA9_1_28309", "HTA9_1_28310", "HTA9_1_28311", "HTA9_1_28312", "HTA9_1_28313", "HTA9_1_28314", "HTA9_1_28315", "HTA9_1_28316", "HTA9_1_28317", "HTA9_1_28318", "HTA9_1_28319", "HTA9_1_28320", "HTA9_1_28321", "HTA9_1_28322", "HTA9_1_28323", "HTA9_1_28324", "HTA9_1_28325", "HTA9_1_28326", "HTA9_1_28327", "HTA9_1_28328", "HTA9_1_28329", "HTA9_1_28330", "HTA9_1_28331", "HTA9_1_28332", "HTA9_1_28333", "HTA9_1_28334", "HTA9_1_28335", "HTA9_1_28336", "HTA9_1_28337", "HTA9_1_28338", "HTA9_1_28339", "HTA9_1_28340", "HTA9_1_28341", "HTA9_1_28342", "HTA9_1_28343", "HTA9_1_28344", "HTA9_1_28345", "HTA9_1_28346", "HTA9_1_28347", "HTA9_1_28348", "HTA9_1_28349", "HTA9_1_28350", "HTA9_1_28351", "HTA9_1_28352", "HTA9_1_28353", "HTA9_1_28354", "HTA9_1_28355", "HTA9_1_28356", "HTA9_1_28357", "HTA9_1_28358", "HTA9_1_28359", "HTA9_1_28360", "HTA9_1_28361", "HTA9_1_28362", "HTA9_1_28363", "HTA9_1_28364", "HTA9_1_28365", "HTA9_1_28366", "HTA9_1_28367", "HTA9_1_28368", "HTA9_1_28369", "HTA9_1_28370", "HTA9_1_28371", "HTA9_1_28372", "HTA9_1_28373", "HTA9_1_28374", "HTA9_1_28375", "HTA9_1_28376", "HTA9_1_28377", "HTA9_1_28378", "HTA9_1_28379", "HTA9_1_28380", "HTA9_1_28381", "HTA9_1_28382", "HTA9_1_28383", "HTA9_1_28384", "HTA9_1_28385", "HTA9_1_28386", "HTA9_1_28387", "HTA9_1_28388", "HTA9_1_28389", "HTA9_1_28390", "HTA9_1_28391", "HTA9_1_28392", "HTA9_1_28393", "HTA9_1_28394", "HTA9_1_28395", "HTA9_1_28396", "HTA9_1_28397", "HTA9_1_28398", "HTA9_1_28399", "HTA9_1_28400", "HTA9_1_28401", "HTA9_1_28402", "HTA9_1_28403", "HTA9_1_28404", "HTA9_1_28405", "HTA9_1_28406", "HTA9_1_28407", "HTA9_1_28408", "HTA9_1_28409", "HTA9_1_28410", "HTA9_1_28411", "HTA9_1_28412", "HTA9_1_28413", "HTA9_1_28414", "HTA9_1_28415", "HTA9_1_28416", "HTA9_1_28417", "HTA9_1_28418", "HTA9_1_28419", "HTA9_1_28420", "HTA9_1_28421", "HTA9_1_28422", "HTA9_1_28423", "HTA9_1_28424", "HTA9_1_28425", "HTA9_1_28426", "HTA9_1_28427", "HTA9_1_28428", "HTA9_1_28429", "HTA9_1_28430", "HTA9_1_28431", "HTA9_1_28432", "HTA9_1_28433", "HTA9_1_28434", "HTA9_1_28435", "HTA9_1_28436", "HTA9_1_28437", "HTA9_1_28438", "HTA9_1_28439", "HTA9_1_28440", "HTA9_1_28441", "HTA9_1_28442", "HTA9_1_28443", "HTA9_1_28444", "HTA9_1_28445", "HTA9_1_28446", "HTA9_1_28447", "HTA9_1_28448", "HTA9_1_28449", "HTA9_1_28450", "HTA9_1_28451", "HTA9_1_28452", "HTA9_1_28453", "HTA9_1_28454", "HTA9_1_28455", "HTA9_1_28456", "HTA9_1_28457", "HTA9_1_28458", "HTA9_1_28459", "HTA9_1_28460", "HTA9_1_28461", "HTA9_1_28462", "HTA9_1_28463", "HTA9_1_28464", "HTA9_1_28465", "HTA9_1_28466", "HTA9_1_28467", "HTA9_1_28468", "HTA9_1_28469", "HTA9_1_28470", "HTA9_1_28471", "HTA9_1_28472", "HTA9_1_28473", "HTA9_1_28474", "HTA9_1_28475", "HTA9_1_28476", "HTA9_1_28477", "HTA9_1_28478", "HTA9_1_28479", "HTA9_1_28480", "HTA9_1_28481", "HTA9_1_28482", "HTA9_1_28483", "HTA9_1_28484", "HTA9_1_28485", "HTA9_1_28486", "HTA9_1_28487", "HTA9_1_28488", "HTA9_1_28489", "HTA9_1_28490", "HTA9_1_28491", "HTA9_1_28492", "HTA9_1_28493", "HTA9_1_28494", "HTA9_1_28495", "HTA9_1_28496", "HTA9_1_28497", "HTA9_1_28498", "HTA9_1_28499", "HTA9_1_28500", "HTA9_1_28501", "HTA9_1_28502", "HTA9_1_28503", "HTA9_1_28504", "HTA9_1_28505", "HTA9_1_28506", "HTA9_1_28507", "HTA9_1_28508", "HTA9_1_28509", "HTA9_1_28510", "HTA9_1_28511", "HTA9_1_28512", "HTA9_1_28513", "HTA9_1_28514", "HTA9_1_28515", "HTA9_1_28516", "HTA9_1_28517", "HTA9_1_28518", "HTA9_1_28519", "HTA9_1_28520", "HTA9_1_28521", "HTA9_1_28522", "HTA9_1_28523", "HTA9_1_28524", "HTA9_1_28525", "HTA9_1_28526", "HTA9_1_28527", "HTA9_1_28528", "HTA9_1_28529", "HTA9_1_28530", "HTA9_1_28531", "HTA9_1_28532", "HTA9_1_28533", "HTA9_1_28534", "HTA9_1_28535", "HTA9_1_28536", "HTA9_1_28537", "HTA9_1_28538", "HTA9_1_28539", "HTA9_1_28540", "HTA9_1_28541", "HTA9_1_28542", "HTA9_1_28543", "HTA9_1_28544", "HTA9_1_28545", "HTA9_1_28546", "HTA9_1_28547", "HTA9_1_28548", "HTA9_1_28549", "HTA9_1_28550", "HTA9_1_28551", "HTA9_1_28552", "HTA9_1_28553", "HTA9_1_28554", "HTA9_1_28555", "HTA9_1_28556", "HTA9_1_28557", "HTA9_1_28558", "HTA9_1_28559", "HTA9_1_28560", "HTA9_1_28561", "HTA9_1_28562", "HTA9_1_28563", "HTA9_1_28564", "HTA9_1_28565", "HTA9_1_28566", "HTA9_1_28567", "HTA9_1_28568", "HTA9_1_28569", "HTA9_1_28570", "HTA9_1_28571", "HTA9_1_28572", "HTA9_1_28573", "HTA9_1_28574", "HTA9_1_28575", "HTA9_1_28576", "HTA9_1_28577", "HTA9_1_28578", "HTA9_1_28579", "HTA9_1_28580", "HTA9_1_28581", "HTA9_1_28582", "HTA9_1_28583", "HTA9_1_28584", "HTA9_1_28585", "HTA9_1_28586", "HTA9_1_28587", "HTA9_1_28588", "HTA9_1_28589", "HTA9_1_28590", "HTA9_1_28591", "HTA9_1_28592", "HTA9_1_28593", "HTA9_1_28594", "HTA9_1_28595", "HTA9_1_28596", "HTA9_1_28597", "HTA9_1_28598", "HTA9_1_28599", "HTA9_1_28600", "HTA9_1_28601", "HTA9_1_28602", "HTA9_1_28603", "HTA9_1_28604", "HTA9_1_28605", "HTA9_1_28606", "HTA9_1_28607", "HTA9_1_28608", "HTA9_1_28609", "HTA9_1_28610", "HTA9_1_28611", "HTA9_1_28612", "HTA9_1_28613", "HTA9_1_28614", "HTA9_1_28615", "HTA9_1_28616", "HTA9_1_28617", "HTA9_1_28618", "HTA9_1_28619", "HTA9_1_28620", "HTA9_1_28621", "HTA9_1_28622", "HTA9_1_28623", "HTA9_1_28624", "HTA9_1_28625", "HTA9_1_28626", "HTA9_1_28627", "HTA9_1_28628", "HTA9_1_28629", "HTA9_1_28630", "HTA9_1_28631", "HTA9_1_28632", "HTA9_1_28633", "HTA9_1_28634", "HTA9_1_28635", "HTA9_1_28636", "HTA9_1_28637", "HTA9_1_28638", "HTA9_1_28639", "HTA9_1_28640", "HTA9_1_28641", "HTA9_1_28642", "HTA9_1_28643", "HTA9_1_28644", "HTA9_1_28645", "HTA9_1_28646", "HTA9_1_28647", "HTA9_1_28648", "HTA9_1_28649", "HTA9_1_28650", "HTA9_1_28651", "HTA9_1_28652", "HTA9_1_28653", "HTA9_1_28654", "HTA9_1_28655", "HTA9_1_28656", "HTA9_1_28657", "HTA9_1_28658", "HTA9_1_28659", "HTA9_1_28660", "HTA9_1_28661", "HTA9_1_28662", "HTA9_1_28663", "HTA9_1_28664", "HTA9_1_28665", "HTA9_1_28666", "HTA9_1_28667", "HTA9_1_28668", "HTA9_1_28669", "HTA9_1_28670", "HTA9_1_28671", "HTA9_1_28672", "HTA9_1_28673", "HTA9_1_28674", "HTA9_1_28675", "HTA9_1_28676", "HTA9_1_28677", "HTA9_1_28678", "HTA9_1_28679", "HTA9_1_28680", "HTA9_1_28681", "HTA9_1_28682", "HTA9_1_28683", "HTA9_1_28684", "HTA9_1_28685", "HTA9_1_28686", "HTA9_1_28687", "HTA9_1_28688", "HTA9_1_28689", "HTA9_1_28690", "HTA9_1_28691", "HTA9_1_28692", "HTA9_1_28693", "HTA9_1_28694", "HTA9_1_28695", "HTA9_1_28696", "HTA9_1_28697", "HTA9_1_28698", "HTA9_1_28699", "HTA9_1_28700", "HTA9_1_28701", "HTA9_1_28702", "HTA9_1_28703", "HTA9_1_28704", "HTA9_1_28705", "HTA9_1_28706", "HTA9_1_28707", "HTA9_1_28708", "HTA9_1_28709", "HTA9_1_28710", "HTA9_1_28711", "HTA9_1_28712", "HTA9_1_28713", "HTA9_1_28714", "HTA9_1_28715", "HTA9_1_28716", "HTA9_1_28717", "HTA9_1_28718", "HTA9_1_28719", "HTA9_1_28720", "HTA9_1_28721", "HTA9_1_28722", "HTA9_1_28723", "HTA9_1_28724", "HTA9_1_28725", "HTA9_1_28726", "HTA9_1_28727", "HTA9_1_28728", "HTA9_1_28729", "HTA9_1_28730", "HTA9_1_28731", "HTA9_1_28732", "HTA9_1_28733", "HTA9_1_28734", "HTA9_1_28735", "HTA9_1_28736", "HTA9_1_28737", "HTA9_1_28738", "HTA9_1_28739", "HTA9_1_28740", "HTA9_1_28741", "HTA9_1_28742", "HTA9_1_28743", "HTA9_1_28744", "HTA9_1_28745", "HTA9_1_28746", "HTA9_1_28747", "HTA9_1_28748", "HTA9_1_28749", "HTA9_1_28750", "HTA9_1_28751", "HTA9_1_28752", "HTA9_1_28753", "HTA9_1_28754", "HTA9_1_28755", "HTA9_1_28756", "HTA9_1_28757", "HTA9_1_28758", "HTA9_1_28759", "HTA9_1_28760", "HTA9_1_28761", "HTA9_1_28762", "HTA9_1_28763", "HTA9_1_28764", "HTA9_1_28765", "HTA9_1_28766", "HTA9_1_28767", "HTA9_1_28768", "HTA9_1_28769", "HTA9_1_28770", "HTA9_1_28771", "HTA9_1_28772", "HTA9_1_28773", "HTA9_1_28774", "HTA9_1_28775", "HTA9_1_28776", "HTA9_1_28777", "HTA9_1_28778", "HTA9_1_28779", "HTA9_1_28780", "HTA9_1_28781", "HTA9_1_28782", "HTA9_1_28783", "HTA9_1_28784", "HTA9_1_28785", "HTA9_1_28786", "HTA9_1_28787", "HTA9_1_28788", "HTA9_1_28789", "HTA9_1_28790", "HTA9_1_28791", "HTA9_1_28792", "HTA9_1_28793", "HTA9_1_28794", "HTA9_1_28795", "HTA9_1_28796", "HTA9_1_28797", "HTA9_1_28798", "HTA9_1_28799", "HTA9_1_28800", "HTA9_1_28801", "HTA9_1_28802", "HTA9_1_28803", "HTA9_1_28804", "HTA9_1_28805", "HTA9_1_28806", "HTA9_1_28807", "HTA9_1_28808", "HTA9_1_28809", "HTA9_1_28810", "HTA9_1_28811", "HTA9_1_28812", "HTA9_1_28813", "HTA9_1_28814", "HTA9_1_28815", "HTA9_1_28816", "HTA9_1_28817", "HTA9_1_28818", "HTA9_1_28819", "HTA9_1_28820", "HTA9_1_28821", "HTA9_1_28822", "HTA9_1_28823", "HTA9_1_28824", "HTA9_1_28825", "HTA9_1_28826", "HTA9_1_28827", "HTA9_1_28828", "HTA9_1_28829", "HTA9_1_28830", "HTA9_1_28831", "HTA9_1_28832", "HTA9_1_28833", "HTA9_1_28834", "HTA9_1_28835", "HTA9_1_28836", "HTA9_1_28837", "HTA9_1_28838", "HTA9_1_28839", "HTA9_1_28840", "HTA9_1_28841", "HTA9_1_28842", "HTA9_1_28843", "HTA9_1_28844", "HTA9_1_28845", "HTA9_1_28846", "HTA9_1_28847", "HTA9_1_28848", "HTA9_1_28849", "HTA9_1_28850", "HTA9_1_28851", "HTA9_1_28852", "HTA9_1_28853", "HTA9_1_28854", "HTA9_1_28855", "HTA9_1_28856", "HTA9_1_28857", "HTA9_1_28858", "HTA9_1_28859", "HTA9_1_28860", "HTA9_1_28861", "HTA9_1_28862", "HTA9_1_28863", "HTA9_1_28864", "HTA9_1_28865", "HTA9_1_28866", "HTA9_1_28867", "HTA9_1_28868", "HTA9_1_28869", "HTA9_1_28870", "HTA9_1_28871", "HTA9_1_28872", "HTA9_1_28873", "HTA9_1_28874", "HTA9_1_28875", "HTA9_1_28876", "HTA9_1_28877", "HTA9_1_28878", "HTA9_1_28879", "HTA9_1_28880", "HTA9_1_28881", "HTA9_1_28882", "HTA9_1_28883", "HTA9_1_28884", "HTA9_1_28885", "HTA9_1_28886", "HTA9_1_28887", "HTA9_1_28888", "HTA9_1_28889", "HTA9_1_28890", "HTA9_1_28891", "HTA9_1_28892", "HTA9_1_28893", "HTA9_1_28894", "HTA9_1_28895", "HTA9_1_28896", "HTA9_1_28897", "HTA9_1_28898", "HTA9_1_28899", "HTA9_1_28900", "HTA9_1_28901", "HTA9_1_28902", "HTA9_1_28903", "HTA9_1_28904", "HTA9_1_28905", "HTA9_1_28906", "HTA9_1_28907", "HTA9_1_28908", "HTA9_1_28909", "HTA9_1_28910", "HTA9_1_28911", "HTA9_1_28912", "HTA9_1_28913", "HTA9_1_28914", "HTA9_1_28915", "HTA9_1_28916", "HTA9_1_28917", "HTA9_1_28918", "HTA9_1_28919", "HTA9_1_28920", "HTA9_1_28921", "HTA9_1_28922", "HTA9_1_28923", "HTA9_1_28924", "HTA9_1_28925", "HTA9_1_28926", "HTA9_1_28927", "HTA9_1_28928", "HTA9_1_28929", "HTA9_1_28930", "HTA9_1_28931", "HTA9_1_28932", "HTA9_1_28933", "HTA9_1_28934", "HTA9_1_28935", "HTA9_1_28936", "HTA9_1_28937", "HTA9_1_28938", "HTA9_1_28939", "HTA9_1_28940", "HTA9_1_28941", "HTA9_1_28942", "HTA9_1_28943", "HTA9_1_28944", "HTA9_1_28945", "HTA9_1_28946", "HTA9_1_28947", "HTA9_1_28948", "HTA9_1_28949", "HTA9_1_28950", "HTA9_1_28951", "HTA9_1_28952", "HTA9_1_28953", "HTA9_1_28954", "HTA9_1_28955", "HTA9_1_28956", "HTA9_1_28957", "HTA9_1_28958", "HTA9_1_28959", "HTA9_1_28960", "HTA9_1_28961", "HTA9_1_28962", "HTA9_1_28963", "HTA9_1_28964", "HTA9_1_28965", "HTA9_1_28966", "HTA9_1_28967", "HTA9_1_28968", "HTA9_1_28969", "HTA9_1_28970", "HTA9_1_28971", "HTA9_1_28972", "HTA9_1_28973", "HTA9_1_28974", "HTA9_1_28975", "HTA9_1_28976", "HTA9_1_28977", "HTA9_1_28978", "HTA9_1_28979", "HTA9_1_28980", "HTA9_1_28981", "HTA9_1_28982", "HTA9_1_28983", "HTA9_1_28984", "HTA9_1_28985", "HTA9_1_28986", "HTA9_1_28987", "HTA9_1_28988", "HTA9_1_28989", "HTA9_1_28990", "HTA9_1_28991", "HTA9_1_28992", "HTA9_1_28993", "HTA9_1_28994", "HTA9_1_28995", "HTA9_1_28996", "HTA9_1_28997", "HTA9_1_28998", "HTA9_1_28999", "HTA9_1_29000", "HTA9_1_29001", "HTA9_1_29002", "HTA9_1_29003", "HTA9_1_29004", "HTA9_1_29005", "HTA9_1_29006", "HTA9_1_29007", "HTA9_1_29008", "HTA9_1_29009", "HTA9_1_29010", "HTA9_1_29011", "HTA9_1_29012", "HTA9_1_29013", "HTA9_1_29014", "HTA9_1_29015", "HTA9_1_29016", "HTA9_1_29017", "HTA9_1_29018", "HTA9_1_29019", "HTA9_1_29020", "HTA9_1_29021", "HTA9_1_29022", "HTA9_1_29023", "HTA9_1_29024", "HTA9_1_29025", "HTA9_1_29026", "HTA9_1_29027", "HTA9_1_29028", "HTA9_1_29029", "HTA9_1_29030", "HTA9_1_29031", "HTA9_1_29032", "HTA9_1_29033", "HTA9_1_29034", "HTA9_1_29035", "HTA9_1_29036", "HTA9_1_29037", "HTA9_1_29038", "HTA9_1_29039", "HTA9_1_29040", "HTA9_1_29041", "HTA9_1_29042", "HTA9_1_29043", "HTA9_1_29044", "HTA9_1_29045", "HTA9_1_29046", "HTA9_1_29047", "HTA9_1_29048", "HTA9_1_29049", "HTA9_1_29050", "HTA9_1_29051", "HTA9_1_29052", "HTA9_1_29053", "HTA9_1_29054", "HTA9_1_29055", "HTA9_1_29056", "HTA9_1_29057", "HTA9_1_29058", "HTA9_1_29059", "HTA9_1_29060", "HTA9_1_29061", "HTA9_1_29062", "HTA9_1_29063", "HTA9_1_29064", "HTA9_1_29065", "HTA9_1_29066", "HTA9_1_29067", "HTA9_1_29068", "HTA9_1_29069", "HTA9_1_29070", "HTA9_1_29071", "HTA9_1_29072", "HTA9_1_29073", "HTA9_1_29074", "HTA9_1_29075", "HTA9_1_29076", "HTA9_1_29077", "HTA9_1_29078", "HTA9_1_29079", "HTA9_1_29080", "HTA9_1_29081", "HTA9_1_29082", "HTA9_1_29083", "HTA9_1_29084", "HTA9_1_29085", "HTA9_1_29086", "HTA9_1_29087", "HTA9_1_29088", "HTA9_1_29089", "HTA9_1_29090", "HTA9_1_29091", "HTA9_1_29092", "HTA9_1_29093", "HTA9_1_29094", "HTA9_1_29095", "HTA9_1_29096", "HTA9_1_29097", "HTA9_1_29098", "HTA9_1_29099", "HTA9_1_29100", "HTA9_1_29101", "HTA9_1_29102", "HTA9_1_29103", "HTA9_1_29104", "HTA9_1_29105", "HTA9_1_29106", "HTA9_1_29107", "HTA9_1_29108", "HTA9_1_29109", "HTA9_1_29110", "HTA9_1_29111", "HTA9_1_29112", "HTA9_1_29113", "HTA9_1_29114", "HTA9_1_29115", "HTA9_1_29116", "HTA9_1_29117", "HTA9_1_29118", "HTA9_1_29119", "HTA9_1_29120", "HTA9_1_29121", "HTA9_1_29122", "HTA9_1_29123", "HTA9_1_29124", "HTA9_1_29125", "HTA9_1_29126", "HTA9_1_29127", "HTA9_1_29128", "HTA9_1_29129", "HTA9_1_29130", "HTA9_1_29131", "HTA9_1_29132", "HTA9_1_29133", "HTA9_1_29134", "HTA9_1_29135", "HTA9_1_29136", "HTA9_1_29137", "HTA9_1_29138", "HTA9_1_29139", "HTA9_1_29140", "HTA9_1_29141", "HTA9_1_29142", "HTA9_1_29143", "HTA9_1_29144", "HTA9_1_29145", "HTA9_1_29146", "HTA9_1_29147", "HTA9_1_29148", "HTA9_1_29149", "HTA9_1_29150", "HTA9_1_29151", "HTA9_1_29152", "HTA9_1_29153", "HTA9_1_29154", "HTA9_1_29155", "HTA9_1_29156", "HTA9_1_29157", "HTA9_1_29158", "HTA9_1_29159", "HTA9_1_29160", "HTA9_1_29161", "HTA9_1_29162", "HTA9_1_29163", "HTA9_1_29164", "HTA9_1_29165", "HTA9_1_29166", "HTA9_1_29167", "HTA9_1_29168", "HTA9_1_29169", "HTA9_1_29170", "HTA9_1_29171", "HTA9_1_29172", "HTA9_1_29173", "HTA9_1_29174", "HTA9_1_29175", "HTA9_1_29176", "HTA9_1_29177", "HTA9_1_29178", "HTA9_1_29179", "HTA9_1_29180", "HTA9_1_29181", "HTA9_1_29182", "HTA9_1_29183", "HTA9_1_29184", "HTA9_1_29185", "HTA9_1_29186", "HTA9_1_29187", "HTA9_1_29188", "HTA9_1_29189", "HTA9_1_29190", "HTA9_1_29191", "HTA9_1_29192", "HTA9_1_29193", "HTA9_1_29194", "HTA9_1_29195", "HTA9_1_29196", "HTA9_1_29197", "HTA9_1_29198", "HTA9_1_29199", "HTA9_1_29200", "HTA9_1_29201", "HTA9_1_29202", "HTA9_1_29203", "HTA9_1_29204", "HTA9_1_29205", "HTA9_1_29206", "HTA9_1_29207", "HTA9_1_29208", "HTA9_1_29209", "HTA9_1_29210", "HTA9_1_29211", "HTA9_1_29212", "HTA9_1_29213", "HTA9_1_29214", "HTA9_1_29215", "HTA9_1_29216", "HTA9_1_29217", "HTA9_1_29218", "HTA9_1_29219", "HTA9_1_29220", "HTA9_1_29221", "HTA9_1_29222", "HTA9_1_29223", "HTA9_1_29224", "HTA9_1_29225", "HTA9_1_29226", "HTA9_1_29227", "HTA9_1_29228", "HTA9_1_29229", "HTA9_1_29230", "HTA9_1_29231", "HTA9_1_29232", "HTA9_1_29233", "HTA9_1_29234", "HTA9_1_29235", "HTA9_1_29236", "HTA9_1_29237", "HTA9_1_29238", "HTA9_1_29239", "HTA9_1_29240", "HTA9_1_29241", "HTA9_1_29242", "HTA9_1_29243", "HTA9_1_29244", "HTA9_1_29245", "HTA9_1_29246", "HTA9_1_29247", "HTA9_1_29248", "HTA9_1_29249", "HTA9_1_29250", "HTA9_1_29251", "HTA9_1_29252", "HTA9_1_29253", "HTA9_1_29254", "HTA9_1_29255", "HTA9_1_29256", "HTA9_1_29257", "HTA9_1_29258", "HTA9_1_29259", "HTA9_1_29260", "HTA9_1_29261", "HTA9_1_29262", "HTA9_1_29263", "HTA9_1_29264", "HTA9_1_29265", "HTA9_1_29266", "HTA9_1_29267", "HTA9_1_29268", "HTA9_1_29269", "HTA9_1_29270", "HTA9_1_29271", "HTA9_1_29272", "HTA9_1_29273", "HTA9_1_29274", "HTA9_1_29275", "HTA9_1_29276", "HTA9_1_29277", "HTA9_1_29278", "HTA9_1_29279", "HTA9_1_29280", "HTA9_1_29281", "HTA9_1_29282", "HTA9_1_29283", "HTA9_1_29284", "HTA9_1_29285", "HTA9_1_29286", "HTA9_1_29287", "HTA9_1_29288", "HTA9_1_29289", "HTA9_1_29290", "HTA9_1_29291", "HTA9_1_29292", "HTA9_1_29293", "HTA9_1_29294", "HTA9_1_29295", "HTA9_1_29296", "HTA9_1_29297", "HTA9_1_29298", "HTA9_1_29299", "HTA9_1_29300", "HTA9_1_29301", "HTA9_1_29302", "HTA9_1_29303", "HTA9_1_29304", "HTA9_1_29305", "HTA9_1_29306", "HTA9_1_29307", "HTA9_1_29308", "HTA9_1_29309", "HTA9_1_29310", "HTA9_1_29311", "HTA9_1_29312", "HTA9_1_29313", "HTA9_1_29314", "HTA9_1_29315", "HTA9_1_29316", "HTA9_1_29317", "HTA9_1_29318", "HTA9_1_29319", "HTA9_1_29320", "HTA9_1_29321", "HTA9_1_29322", "HTA9_1_29323", "HTA9_1_29324", "HTA9_1_29325", "HTA9_1_29326", "HTA9_1_29327", "HTA9_1_29328", "HTA9_1_29329", "HTA9_1_29330", "HTA9_1_29331", "HTA9_1_29332", "HTA9_1_29333", "HTA9_1_29334", "HTA9_1_29335", "HTA9_1_29336", "HTA9_1_29337", "HTA9_1_29338", "HTA9_1_29339", "HTA9_1_29340", "HTA9_1_29341", "HTA9_1_29342", "HTA9_1_29343", "HTA9_1_29344", "HTA9_1_29345", "HTA9_1_29346", "HTA9_1_29347", "HTA9_1_29348", "HTA9_1_29349", "HTA9_1_29350", "HTA9_1_29351", "HTA9_1_29352", "HTA9_1_29353", "HTA9_1_29354", "HTA9_1_29355", "HTA9_1_29356", "HTA9_1_29357", "HTA9_1_29358", "HTA9_1_29359", "HTA9_1_29360", "HTA9_1_29361", "HTA9_1_29362", "HTA9_1_29363", "HTA9_1_29364", "HTA9_1_29365", "HTA9_1_29366", "HTA9_1_29367", "HTA9_1_29368", "HTA9_1_29369", "HTA9_1_29370", "HTA9_1_29371", "HTA9_1_29372", "HTA9_1_29373", "HTA9_1_29374", "HTA9_1_29375", "HTA9_1_29376", "HTA9_1_29377", "HTA9_1_29378", "HTA9_1_29379", "HTA9_1_29380", "HTA9_1_29381", "HTA9_1_29382", "HTA9_1_29383", "HTA9_1_29384", "HTA9_1_29385", "HTA9_1_29386", "HTA9_1_29387", "HTA9_1_29388", "HTA9_1_29389", "HTA9_1_29390", "HTA9_1_29391", "HTA9_1_29392", "HTA9_1_29393", "HTA9_1_29394", "HTA9_1_29395", "HTA9_1_29396", "HTA9_1_29397", "HTA9_1_29398", "HTA9_1_29399", "HTA9_1_29400", "HTA9_1_29401", "HTA9_1_29402", "HTA9_1_29403", "HTA9_1_29404", "HTA9_1_29405", "HTA9_1_29406", "HTA9_1_29407", "HTA9_1_29408", "HTA9_1_29409", "HTA9_1_29410", "HTA9_1_29411", "HTA9_1_29412", "HTA9_1_29413", "HTA9_1_29414", "HTA9_1_29415", "HTA9_1_29416", "HTA9_1_29417", "HTA9_1_29418", "HTA9_1_29419", "HTA9_1_29420", "HTA9_1_29421", "HTA9_1_29422", "HTA9_1_29423", "HTA9_1_29424", "HTA9_1_29425", "HTA9_1_29426", "HTA9_1_29427", "HTA9_1_29428", "HTA9_1_29429", "HTA9_1_29430", "HTA9_1_29431", "HTA9_1_29432", "HTA9_1_29433", "HTA9_1_29434", "HTA9_1_29435", "HTA9_1_29436", "HTA9_1_29437", "HTA9_1_29438", "HTA9_1_29439", "HTA9_1_29440", "HTA9_1_29441", "HTA9_1_29442", "HTA9_1_29443", "HTA9_1_29444", "HTA9_1_29445", "HTA9_1_29446", "HTA9_1_29447", "HTA9_1_29448", "HTA9_1_29449", "HTA9_1_29450", "HTA9_1_29451", "HTA9_1_29452", "HTA9_1_29453", "HTA9_1_29454", "HTA9_1_29455", "HTA9_1_29456", "HTA9_1_29457", "HTA9_1_29458", "HTA9_1_29459", "HTA9_1_29460", "HTA9_1_29461", "HTA9_1_29462", "HTA9_1_29463", "HTA9_1_29464", "HTA9_1_29465", "HTA9_1_29466", "HTA9_1_29467", "HTA9_1_29468", "HTA9_1_29469", "HTA9_1_29470", "HTA9_1_29471", "HTA9_1_29472", "HTA9_1_29473", "HTA9_1_29474", "HTA9_1_29475", "HTA9_1_29476", "HTA9_1_29477", "HTA9_1_29478", "HTA9_1_29479", "HTA9_1_29480", "HTA9_1_29481", "HTA9_1_29482", "HTA9_1_29483", "HTA9_1_29484", "HTA9_1_29485", "HTA9_1_29486", "HTA9_1_29487", "HTA9_1_29488", "HTA9_1_29489", "HTA9_1_29490", "HTA9_1_29491", "HTA9_1_29492", "HTA9_1_29493", "HTA9_1_29494", "HTA9_1_29495", "HTA9_1_29496", "HTA9_1_29497", "HTA9_1_29498", "HTA9_1_29499", "HTA9_1_29500", "HTA9_1_29501", "HTA9_1_29502", "HTA9_1_29503", "HTA9_1_29504", "HTA9_1_29505", "HTA9_1_29506", "HTA9_1_29507", "HTA9_1_29508", "HTA9_1_29509", "HTA9_1_29510", "HTA9_1_29511", "HTA9_1_29512", "HTA9_1_29513", "HTA9_1_29514", "HTA9_1_29515", "HTA9_1_29516", "HTA9_1_29517", "HTA9_1_29518", "HTA9_1_29519", "HTA9_1_29520", "HTA9_1_29521", "HTA9_1_29522", "HTA9_1_29523", "HTA9_1_29524", "HTA9_1_29525", "HTA9_1_29526", "HTA9_1_29527", "HTA9_1_29528", "HTA9_1_29529", "HTA9_1_29530", "HTA9_1_29531", "HTA9_1_29532", "HTA9_1_29533", "HTA9_1_29534", "HTA9_1_29535", "HTA9_1_29536", "HTA9_1_29537", "HTA9_1_29538", "HTA9_1_29539", "HTA9_1_29540", "HTA9_1_29541", "HTA9_1_29542", "HTA9_1_29543", "HTA9_1_29544", "HTA9_1_29545", "HTA9_1_29546", "HTA9_1_29547", "HTA9_1_29548", "HTA9_1_29549", "HTA9_1_29550", "HTA9_1_29551", "HTA9_1_29552", "HTA9_1_29553", "HTA9_1_29554", "HTA9_1_29555", "HTA9_1_29556", "HTA9_1_29557", "HTA9_1_29558", "HTA9_1_29559", "HTA9_1_29560", "HTA9_1_29561", "HTA9_1_29562", "HTA9_1_29563", "HTA9_1_29564", "HTA9_1_29565", "HTA9_1_29566", "HTA9_1_29567", "HTA9_1_29568", "HTA9_1_29569", "HTA9_1_29570", "HTA9_1_29571", "HTA9_1_29572", "HTA9_1_29573", "HTA9_1_29574", "HTA9_1_29575", "HTA9_1_29576", "HTA9_1_29577", "HTA9_1_29578", "HTA9_1_29579", "HTA9_1_29580", "HTA9_1_29581", "HTA9_1_29582", "HTA9_1_29583", "HTA9_1_29584", "HTA9_1_29585", "HTA9_1_29586", "HTA9_1_29587", "HTA9_1_29588", "HTA9_1_29589", "HTA9_1_29590", "HTA9_1_29591", "HTA9_1_29592", "HTA9_1_29593", "HTA9_1_29594", "HTA9_1_29595", "HTA9_1_29596", "HTA9_1_29597", "HTA9_1_29598", "HTA9_1_29599", "HTA9_1_29600", "HTA9_1_29601", "HTA9_1_29602", "HTA9_1_29603", "HTA9_1_29604", "HTA9_1_29605", "HTA9_1_29606", "HTA9_1_29607", "HTA9_1_29608", "HTA9_1_29609", "HTA9_1_29610", "HTA9_1_29611", "HTA9_1_29612", "HTA9_1_29613", "HTA9_1_29614", "HTA9_1_29615", "HTA9_1_29616", "HTA9_1_29617", "HTA9_1_29618", "HTA9_1_29619", "HTA9_1_29620", "HTA9_1_29621", "HTA9_1_29622", "HTA9_1_29623", "HTA9_1_29624", "HTA9_1_29625", "HTA9_1_29626", "HTA9_1_29627", "HTA9_1_29628", "HTA9_1_29629", "HTA9_1_29630", "HTA9_1_29631", "HTA9_1_29632", "HTA9_1_29633", "HTA9_1_29634", "HTA9_1_29635", "HTA9_1_29636", "HTA9_1_29637", "HTA9_1_29638", "HTA9_1_29639", "HTA9_1_29640", "HTA9_1_29641", "HTA9_1_29642", "HTA9_1_29643", "HTA9_1_29644", "HTA9_1_29645", "HTA9_1_29646", "HTA9_1_29647", "HTA9_1_29648", "HTA9_1_29649", "HTA9_1_29650", "HTA9_1_29651", "HTA9_1_29652", "HTA9_1_29653", "HTA9_1_29654", "HTA9_1_29655", "HTA9_1_29656", "HTA9_1_29657", "HTA9_1_29658", "HTA9_1_29659", "HTA9_1_29660", "HTA9_1_29661", "HTA9_1_29662", "HTA9_1_29663", "HTA9_1_29664", "HTA9_1_29665", "HTA9_1_29666", "HTA9_1_29667", "HTA9_1_29668", "HTA9_1_29669", "HTA9_1_29670", "HTA9_1_29671", "HTA9_1_29672", "HTA9_1_29673", "HTA9_1_29674", "HTA9_1_29675", "HTA9_1_29676", "HTA9_1_29677", "HTA9_1_29678", "HTA9_1_29679", "HTA9_1_29680", "HTA9_1_29681", "HTA9_1_29682", "HTA9_1_29683", "HTA9_1_29684", "HTA9_1_29685", "HTA9_1_29686", "HTA9_1_29687", "HTA9_1_29688", "HTA9_1_29689", "HTA9_1_29690", "HTA9_1_29691", "HTA9_1_29692", "HTA9_1_29693", "HTA9_1_29694", "HTA9_1_29695", "HTA9_1_29696", "HTA9_1_29697", "HTA9_1_29698", "HTA9_1_29699", "HTA9_1_29700", "HTA9_1_29701", "HTA9_1_29702", "HTA9_1_29703", "HTA9_1_29704", "HTA9_1_29705", "HTA9_1_29706", "HTA9_1_29707", "HTA9_1_29708", "HTA9_1_29709", "HTA9_1_29710", "HTA9_1_29711", "HTA9_1_29712", "HTA9_1_29713", "HTA9_1_29714", "HTA9_1_29715", "HTA9_1_29716", "HTA9_1_29717", "HTA9_1_29718", "HTA9_1_29719", "HTA9_1_29720", "HTA9_1_29721", "HTA9_1_29722", "HTA9_1_29723", "HTA9_1_29724", "HTA9_1_29725", "HTA9_1_29726", "HTA9_1_29727", "HTA9_1_29728", "HTA9_1_29729", "HTA9_1_29730", "HTA9_1_29731", "HTA9_1_29732", "HTA9_1_29733", "HTA9_1_29734", "HTA9_1_29735", "HTA9_1_29736", "HTA9_1_29737", "HTA9_1_29738", "HTA9_1_29739", "HTA9_1_29740", "HTA9_1_29741", "HTA9_1_29742", "HTA9_1_29743", "HTA9_1_29744", "HTA9_1_29745", "HTA9_1_29746", "HTA9_1_29747", "HTA9_1_29748", "HTA9_1_29749", "HTA9_1_29750", "HTA9_1_29751", "HTA9_1_29752", "HTA9_1_29753", "HTA9_1_29754", "HTA9_1_29755", "HTA9_1_29756", "HTA9_1_29757", "HTA9_1_29758", "HTA9_1_29759", "HTA9_1_29760", "HTA9_1_29761", "HTA9_1_29762", "HTA9_1_29763", "HTA9_1_29764", "HTA9_1_29765", "HTA9_1_29766", "HTA9_1_29767", "HTA9_1_29768", "HTA9_1_29769", "HTA9_1_29770", "HTA9_1_29771", "HTA9_1_29772", "HTA9_1_29773", "HTA9_1_29774", "HTA9_1_29775", "HTA9_1_29776", "HTA9_1_29777", "HTA9_1_29778", "HTA9_1_29779", "HTA9_1_29780", "HTA9_1_29781", "HTA9_1_29782", "HTA9_1_29783", "HTA9_1_29784", "HTA9_1_29785", "HTA9_1_29786", "HTA9_1_29787", "HTA9_1_29788", "HTA9_1_29789", "HTA9_1_29790", "HTA9_1_29791", "HTA9_1_29792", "HTA9_1_29793", "HTA9_1_29794", "HTA9_1_29795", "HTA9_1_29796", "HTA9_1_29797", "HTA9_1_29798", "HTA9_1_29799", "HTA9_1_29800", "HTA9_1_29801", "HTA9_1_29802", "HTA9_1_29803", "HTA9_1_29804", "HTA9_1_29805", "HTA9_1_29806", "HTA9_1_29807", "HTA9_1_29808", "HTA9_1_29809", "HTA9_1_29810", "HTA9_1_29811", "HTA9_1_29812", "HTA9_1_29813", "HTA9_1_29814", "HTA9_1_29815", "HTA9_1_29816", "HTA9_1_29817", "HTA9_1_29818", "HTA9_1_29819", "HTA9_1_29820", "HTA9_1_29821", "HTA9_1_29822", "HTA9_1_29823", "HTA9_1_29824", "HTA9_1_29825", "HTA9_1_29826", "HTA9_1_29827", "HTA9_1_29828", "HTA9_1_29829", "HTA9_1_29830", "HTA9_1_29831", "HTA9_1_29832", "HTA9_1_29833", "HTA9_1_29834", "HTA9_1_29835", "HTA9_1_29836", "HTA9_1_29837", "HTA9_1_29838", "HTA9_1_29839", "HTA9_1_29840", "HTA9_1_29841", "HTA9_1_29842", "HTA9_1_29843", "HTA9_1_29844", "HTA9_1_29845", "HTA9_1_29846", "HTA9_1_29847", "HTA9_1_29848", "HTA9_1_29849", "HTA9_1_29850", "HTA9_1_29851", "HTA9_1_29852", "HTA9_1_29853", "HTA9_1_29854", "HTA9_1_29855", "HTA9_1_29856", "HTA9_1_29857", "HTA9_1_29858", "HTA9_1_29859", "HTA9_1_29860", "HTA9_1_29861", "HTA9_1_29862", "HTA9_1_29863", "HTA9_1_29864", "HTA9_1_29865", "HTA9_1_29866", "HTA9_1_29867", "HTA9_1_29868", "HTA9_1_29869", "HTA9_1_29870", "HTA9_1_29871", "HTA9_1_29872", "HTA9_1_29873", "HTA9_1_29874", "HTA9_1_29875", "HTA9_1_29876", "HTA9_1_29877", "HTA9_1_29878", "HTA9_1_29879", "HTA9_1_29880", "HTA9_1_29881", "HTA9_1_29882", "HTA9_1_29883", "HTA9_1_29884", "HTA9_1_29885", "HTA9_1_29886", "HTA9_1_29887", "HTA9_1_29888", "HTA9_1_29889", "HTA9_1_29890", "HTA9_1_29891", "HTA9_1_29892", "HTA9_1_29893", "HTA9_1_29894", "HTA9_1_29895", "HTA9_1_29896", "HTA9_1_29897", "HTA9_1_29898", "HTA9_1_29899", "HTA9_1_29900", "HTA9_1_29901", "HTA9_1_29902", "HTA9_1_29903", "HTA9_1_29904", "HTA9_1_29905", "HTA9_1_29906", "HTA9_1_29907", "HTA9_1_29908", "HTA9_1_29909", "HTA9_1_29910", "HTA9_1_29911", "HTA9_1_29912", "HTA9_1_29913", "HTA9_1_29914", "HTA9_1_29915", "HTA9_1_29916", "HTA9_1_29917", "HTA9_1_29918", "HTA9_1_29919", "HTA9_1_29920", "HTA9_1_29921", "HTA9_1_29922", "HTA9_1_29923", "HTA9_1_29924", "HTA9_1_29925", "HTA9_1_29926", "HTA9_1_29927", "HTA9_1_29928", "HTA9_1_29929", "HTA9_1_29930", "HTA9_1_29931", "HTA9_1_29932", "HTA9_1_29933", "HTA9_1_29934", "HTA9_1_29935", "HTA9_1_29936", "HTA9_1_29937", "HTA9_1_29938", "HTA9_1_29939", "HTA9_1_29940", "HTA9_1_29941", "HTA9_1_29942", "HTA9_1_29943", "HTA9_1_29944", "HTA9_1_29945", "HTA9_1_29946", "HTA9_1_29947", "HTA9_1_29948", "HTA9_1_29949", "HTA9_1_29950", "HTA9_1_29951", "HTA9_1_29952", "HTA9_1_29953", "HTA9_1_29954", "HTA9_1_29955", "HTA9_1_29956", "HTA9_1_29957", "HTA9_1_29958", "HTA9_1_29959", "HTA9_1_29960", "HTA9_1_29961", "HTA9_1_29962", "HTA9_1_29963", "HTA9_1_29964", "HTA9_1_29965", "HTA9_1_29966", "HTA9_1_29967", 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"HTA9_1_30216", "HTA9_1_30217", "HTA9_1_30218", "HTA9_1_30219", "HTA9_1_30220", "HTA9_1_30221", "HTA9_1_30222", "HTA9_1_30223", "HTA9_1_30224", "HTA9_1_30225", "HTA9_1_30226", "HTA9_1_30227", "HTA9_1_30228", "HTA9_1_30229", "HTA9_1_30230", "HTA9_1_30231", "HTA9_1_30232", "HTA9_1_30233", "HTA9_1_30234", "HTA9_1_30235", "HTA9_1_30236", "HTA9_1_30237", "HTA9_1_30238", "HTA9_1_30239", "HTA9_1_30240", "HTA9_1_30241", "HTA9_1_30242", "HTA9_1_30243", "HTA9_1_30244", "HTA9_1_30245", "HTA9_1_30246", "HTA9_1_30247", "HTA9_1_30248", "HTA9_1_30249", "HTA9_1_30250", "HTA9_1_30251", "HTA9_1_30252", "HTA9_1_30253", "HTA9_1_30254", "HTA9_1_30255", "HTA9_1_30256", "HTA9_1_30257", "HTA9_1_30258", "HTA9_1_30259", "HTA9_1_30260", "HTA9_1_30261", "HTA9_1_30262", "HTA9_1_30263", "HTA9_1_30264", "HTA9_1_30265", "HTA9_1_30266", "HTA9_1_30267", "HTA9_1_30268", "HTA9_1_30269", "HTA9_1_30270", "HTA9_1_30271", "HTA9_1_30272", "HTA9_1_30273", "HTA9_1_30274", "HTA9_1_30275", "HTA9_1_30276", "HTA9_1_30277", "HTA9_1_30278", "HTA9_1_30279", "HTA9_1_30280", "HTA9_1_30281", "HTA9_1_30282", "HTA9_1_30283", "HTA9_1_30284", "HTA9_1_30285", "HTA9_1_30286", "HTA9_1_30287", "HTA9_1_30288", "HTA9_1_30289", "HTA9_1_30290", "HTA9_1_30291", "HTA9_1_30292", "HTA9_1_30293", "HTA9_1_30294", "HTA9_1_30295", "HTA9_1_30296", "HTA9_1_30297", "HTA9_1_30298", "HTA9_1_30299", "HTA9_1_30300", "HTA9_1_30301", "HTA9_1_30302", "HTA9_1_30303", "HTA9_1_30304", "HTA9_1_30305", "HTA9_1_30306", "HTA9_1_30307", "HTA9_1_30308", "HTA9_1_30309", "HTA9_1_30310", "HTA9_1_30311", "HTA9_1_30312", "HTA9_1_30313", "HTA9_1_30314", "HTA9_1_30315", "HTA9_1_30316", "HTA9_1_30317", "HTA9_1_30318", "HTA9_1_30319", "HTA9_1_30320", "HTA9_1_30321", "HTA9_1_30322", "HTA9_1_30323", "HTA9_1_30324", "HTA9_1_30325", "HTA9_1_30326", "HTA9_1_30327", "HTA9_1_30328", "HTA9_1_30329", "HTA9_1_30330", "HTA9_1_30331", "HTA9_1_30332", "HTA9_1_30333", "HTA9_1_30334", "HTA9_1_30335", "HTA9_1_30336", "HTA9_1_30337", "HTA9_1_30338", "HTA9_1_30339", "HTA9_1_30340", "HTA9_1_30341", "HTA9_1_30342", "HTA9_1_30343", "HTA9_1_30344", "HTA9_1_30345", "HTA9_1_30346", "HTA9_1_30347", "HTA9_1_30348", "HTA9_1_30349", "HTA9_1_30350", "HTA9_1_30351", "HTA9_1_30352", "HTA9_1_30353", "HTA9_1_30354", "HTA9_1_30355", "HTA9_1_30356", "HTA9_1_30357", "HTA9_1_30358", "HTA9_1_30359", "HTA9_1_30360", "HTA9_1_30361", "HTA9_1_30362", "HTA9_1_30363", "HTA9_1_30364", "HTA9_1_30365", "HTA9_1_30366", "HTA9_1_30367", "HTA9_1_30368", "HTA9_1_30369", "HTA9_1_30370", "HTA9_1_30371", "HTA9_1_30372", "HTA9_1_30373", "HTA9_1_30374", "HTA9_1_30375", "HTA9_1_30376", "HTA9_1_30377", "HTA9_1_30378", "HTA9_1_30379", "HTA9_1_30380", "HTA9_1_30381", "HTA9_1_30382", "HTA9_1_30383", "HTA9_1_30384", "HTA9_1_30385", "HTA9_1_30386", "HTA9_1_30387", "HTA9_1_30388", "HTA9_1_30389", "HTA9_1_30390", "HTA9_1_30391", "HTA9_1_30392", "HTA9_1_30393", "HTA9_1_30394", "HTA9_1_30395", "HTA9_1_30396", "HTA9_1_30397", "HTA9_1_30398", "HTA9_1_30399", "HTA9_1_30400", "HTA9_1_30401", "HTA9_1_30402", "HTA9_1_30403", "HTA9_1_30404", "HTA9_1_30405", "HTA9_1_30406", "HTA9_1_30407", "HTA9_1_30408", "HTA9_1_30409", "HTA9_1_30410", "HTA9_1_30411", "HTA9_1_30412", "HTA9_1_30413", "HTA9_1_30414", "HTA9_1_30415", "HTA9_1_30416", "HTA9_1_30417", "HTA9_1_30418", "HTA9_1_30419", "HTA9_1_30420", "HTA9_1_30421", "HTA9_1_30422", "HTA9_1_30423", "HTA9_1_30424", "HTA9_1_30425", "HTA9_1_30426", "HTA9_1_30427", "HTA9_1_30428", "HTA9_1_30429", "HTA9_1_30430", "HTA9_1_30431", "HTA9_1_30432", "HTA9_1_30433", "HTA9_1_30434", "HTA9_1_30435", "HTA9_1_30436", "HTA9_1_30437", "HTA9_1_30438", "HTA9_1_30439", "HTA9_1_30440", "HTA9_1_30441", "HTA9_1_30442", "HTA9_1_30443", "HTA9_1_30444", "HTA9_1_30445", "HTA9_1_30446", "HTA9_1_30447", "HTA9_1_30448", "HTA9_1_30449", "HTA9_1_30450", "HTA9_1_30451", "HTA9_1_30452", "HTA9_1_30453", "HTA9_1_30454", "HTA9_1_30455", "HTA9_1_30456", "HTA9_1_30457", "HTA9_1_30458", "HTA9_1_30459", "HTA9_1_30460", "HTA9_1_30461", "HTA9_1_30462", "HTA9_1_30463", "HTA9_1_30464", "HTA9_1_30465", "HTA9_1_30466", "HTA9_1_30467", "HTA9_1_30468", "HTA9_1_30469", "HTA9_1_30470", "HTA9_1_30471", "HTA9_1_30472", "HTA9_1_30473", "HTA9_1_30474", "HTA9_1_30475", "HTA9_1_30476", "HTA9_1_30477", "HTA9_1_30478", "HTA9_1_30479", "HTA9_1_30480", "HTA9_1_30481", "HTA9_1_30482", "HTA9_1_30483", "HTA9_1_30484", "HTA9_1_30485", "HTA9_1_30486", "HTA9_1_30487", "HTA9_1_30488", "HTA9_1_30489", "HTA9_1_30490", "HTA9_1_30491", "HTA9_1_30492", "HTA9_1_30493", "HTA9_1_30494", "HTA9_1_30495", "HTA9_1_30496", "HTA9_1_30497", "HTA9_1_30498", "HTA9_1_30499", "HTA9_1_30500", "HTA9_1_30501", "HTA9_1_30502", "HTA9_1_30503", "HTA9_1_30504", "HTA9_1_30505", "HTA9_1_30506", "HTA9_1_30507", "HTA9_1_30508", "HTA9_1_30509", "HTA9_1_30510", "HTA9_1_30511", "HTA9_1_30512", "HTA9_1_30513", "HTA9_1_30514", "HTA9_1_30515", "HTA9_1_30516", "HTA9_1_30517", "HTA9_1_30518", "HTA9_1_30519", "HTA9_1_30520", "HTA9_1_30521", "HTA9_1_30522", "HTA9_1_30523", "HTA9_1_30524", "HTA9_1_30525", "HTA9_1_30526", "HTA9_1_30527", "HTA9_1_30528", "HTA9_1_30529", "HTA9_1_30530", "HTA9_1_30531", "HTA9_1_30532", "HTA9_1_30533", "HTA9_1_30534", "HTA9_1_30535", "HTA9_1_30536", "HTA9_1_30537", "HTA9_1_30538", "HTA9_1_30539", "HTA9_1_30540", "HTA9_1_30541", "HTA9_1_30542", "HTA9_1_30543", "HTA9_1_30544", "HTA9_1_30545", "HTA9_1_30546", "HTA9_1_30547", "HTA9_1_30548", "HTA9_1_30549", "HTA9_1_30550", "HTA9_1_30551", "HTA9_1_30552", "HTA9_1_30553", "HTA9_1_30554", "HTA9_1_30555", "HTA9_1_30556", "HTA9_1_30557", "HTA9_1_30558", "HTA9_1_30559", "HTA9_1_30560", "HTA9_1_30561", "HTA9_1_30562", "HTA9_1_30563", "HTA9_1_30564", "HTA9_1_30565", "HTA9_1_30566", "HTA9_1_30567", "HTA9_1_30568", "HTA9_1_30569", "HTA9_1_30570", "HTA9_1_30571", "HTA9_1_30572", "HTA9_1_30573", "HTA9_1_30574", "HTA9_1_30575", "HTA9_1_30576", "HTA9_1_30577", "HTA9_1_30578", "HTA9_1_30579", "HTA9_1_30580", "HTA9_1_30581", "HTA9_1_30582", "HTA9_1_30583", "HTA9_1_30584", "HTA9_1_30585", "HTA9_1_30586", "HTA9_1_30587", "HTA9_1_30588", "HTA9_1_30589", "HTA9_1_30590", "HTA9_1_30591", "HTA9_1_30592", "HTA9_1_30593", "HTA9_1_30594", "HTA9_1_30595", "HTA9_1_30596", "HTA9_1_30597", "HTA9_1_30598", "HTA9_1_30599", "HTA9_1_30600", "HTA9_1_30601", "HTA9_1_30602", "HTA9_1_30603", "HTA9_1_30604", "HTA9_1_30605", "HTA9_1_30606", "HTA9_1_30607", "HTA9_1_30608", "HTA9_1_30609", "HTA9_1_30610", "HTA9_1_30611", "HTA9_1_30612", "HTA9_1_30613", "HTA9_1_30614", "HTA9_1_30615", "HTA9_1_30616", "HTA9_1_30617", "HTA9_1_30618", "HTA9_1_30619", "HTA9_1_30620", "HTA9_1_30621", "HTA9_1_30622", "HTA9_1_30623", "HTA9_1_30624", "HTA9_1_30625", "HTA9_1_30626", "HTA9_1_30627", "HTA9_1_30628", "HTA9_1_30629", "HTA9_1_30630", "HTA9_1_30631", "HTA9_1_30632", "HTA9_1_30633", "HTA9_1_30634", "HTA9_1_30635", "HTA9_1_30636", "HTA9_1_30637", "HTA9_1_30638", "HTA9_1_30639", "HTA9_1_30640", "HTA9_1_30641", "HTA9_1_30642", "HTA9_1_30643", "HTA9_1_30644", "HTA9_1_30645", "HTA9_1_30646", "HTA9_1_30647", "HTA9_1_30648", "HTA9_1_30649", "HTA9_1_30650", "HTA9_1_30651", "HTA9_1_30652", "HTA9_1_30653", "HTA9_1_30654", "HTA9_1_30655", "HTA9_1_30656", "HTA9_1_30657", "HTA9_1_30658", "HTA9_1_30659", "HTA9_1_30660", "HTA9_1_30661", "HTA9_1_30662", "HTA9_1_30663", "HTA9_1_30664", "HTA9_1_30665", "HTA9_1_30666", "HTA9_1_30667", "HTA9_1_30668", "HTA9_1_30669", "HTA9_1_30670", "HTA9_1_30671", "HTA9_1_30672", "HTA9_1_30673", "HTA9_1_30674", "HTA9_1_30675", "HTA9_1_30676", "HTA9_1_30677", "HTA9_1_30678", "HTA9_1_30679", "HTA9_1_30680", "HTA9_1_30681", "HTA9_1_30682", "HTA9_1_30683", "HTA9_1_30684", "HTA9_1_30685", "HTA9_1_30686", "HTA9_1_30687", "HTA9_1_30688", "HTA9_1_30689", "HTA9_1_30690", "HTA9_1_30691", "HTA9_1_30692", "HTA9_1_30693", "HTA9_1_30694", "HTA9_1_30695", "HTA9_1_30696", "HTA9_1_30697", "HTA9_1_30698", "HTA9_1_30699", "HTA9_1_30700", "HTA9_1_30701", "HTA9_1_30702", "HTA9_1_30703", "HTA9_1_30704", "HTA9_1_30705", "HTA9_1_30706", "HTA9_1_30707", "HTA9_1_30708", "HTA9_1_30709", "HTA9_1_30710", "HTA9_1_30711", "HTA9_1_30712", "HTA9_1_30713", "HTA9_1_30714", "HTA9_1_30715", "HTA9_1_30716", "HTA9_1_30717", "HTA9_1_30718", "HTA9_1_30719", "HTA9_1_30720", "HTA9_1_30721", "HTA9_1_30722", "HTA9_1_30723", "HTA9_1_30724", "HTA9_1_30725", "HTA9_1_30726", "HTA9_1_30727", "HTA9_1_30728", "HTA9_1_30729", "HTA9_1_30730", "HTA9_1_30731", "HTA9_1_30732", "HTA9_1_30733", "HTA9_1_30734", "HTA9_1_30735", "HTA9_1_30736", "HTA9_1_30737", "HTA9_1_30738", "HTA9_1_30739", "HTA9_1_30740", "HTA9_1_30741", "HTA9_1_30742", "HTA9_1_30743", "HTA9_1_30744", "HTA9_1_30745", "HTA9_1_30746", "HTA9_1_30747", "HTA9_1_30748", "HTA9_1_30749", "HTA9_1_30750", "HTA9_1_30751", "HTA9_1_30752", "HTA9_1_30753", "HTA9_1_30754", "HTA9_1_30755", "HTA9_1_30756", "HTA9_1_30757", "HTA9_1_30758", "HTA9_1_30759", "HTA9_1_30760", "HTA9_1_30761", "HTA9_1_30762", "HTA9_1_30763", "HTA9_1_30764", "HTA9_1_30765", "HTA9_1_30766", "HTA9_1_30767", "HTA9_1_30768", "HTA9_1_30769", "HTA9_1_30770", "HTA9_1_30771", "HTA9_1_30772", "HTA9_1_30773", "HTA9_1_30774", "HTA9_1_30775", "HTA9_1_30776", "HTA9_1_30777", "HTA9_1_30778", "HTA9_1_30779", "HTA9_1_30780", "HTA9_1_30781", "HTA9_1_30782", "HTA9_1_30783", "HTA9_1_30784", "HTA9_1_30785", "HTA9_1_30786", "HTA9_1_30787", "HTA9_1_30788", "HTA9_1_30789", "HTA9_1_30790", "HTA9_1_30791", "HTA9_1_30792", "HTA9_1_30793", "HTA9_1_30794", "HTA9_1_30795", "HTA9_1_30796", "HTA9_1_30797", "HTA9_1_30798", "HTA9_1_30799", "HTA9_1_30800", "HTA9_1_30801", "HTA9_1_30802", "HTA9_1_30803", "HTA9_1_30804", "HTA9_1_30805", "HTA9_1_30806", "HTA9_1_30807", "HTA9_1_30808", "HTA9_1_30809", "HTA9_1_30810", "HTA9_1_30811", "HTA9_1_30812", "HTA9_1_30813", "HTA9_1_30814", "HTA9_1_30815", "HTA9_1_30816", "HTA9_1_30817", "HTA9_1_30818", "HTA9_1_30819", "HTA9_1_30820", "HTA9_1_30821", "HTA9_1_30822", "HTA9_1_30823", "HTA9_1_30824", "HTA9_1_30825", "HTA9_1_30826", "HTA9_1_30827", "HTA9_1_30828", "HTA9_1_30829", "HTA9_1_30830", "HTA9_1_30831", "HTA9_1_30832", "HTA9_1_30833", "HTA9_1_30834", "HTA9_1_30835", "HTA9_1_30836", "HTA9_1_30837", "HTA9_1_30838", "HTA9_1_30839", "HTA9_1_30840", "HTA9_1_30841", "HTA9_1_30842", "HTA9_1_30843", "HTA9_1_30844", "HTA9_1_30845", "HTA9_1_30846", "HTA9_1_30847", "HTA9_1_30848", "HTA9_1_30849", "HTA9_1_30850", "HTA9_1_30851", "HTA9_1_30852", "HTA9_1_30853", "HTA9_1_30854", "HTA9_1_30855", "HTA9_1_30856", "HTA9_1_30857", "HTA9_1_30858", "HTA9_1_30859", "HTA9_1_30860", "HTA9_1_30861", "HTA9_1_30862", "HTA9_1_30863", "HTA9_1_30864", "HTA9_1_30865", "HTA9_1_30866", "HTA9_1_30867", "HTA9_1_30868", "HTA9_1_30869", "HTA9_1_30870", "HTA9_1_30871", "HTA9_1_30872", "HTA9_1_30873", "HTA9_1_30874", "HTA9_1_30875", "HTA9_1_30876", "HTA9_1_30877", "HTA9_1_30878", "HTA9_1_30879", "HTA9_1_30880", "HTA9_1_30881", "HTA9_1_30882", "HTA9_1_30883", "HTA9_1_30884", "HTA9_1_30885", "HTA9_1_30886", "HTA9_1_30887", "HTA9_1_30888", "HTA9_1_30889", "HTA9_1_30890", "HTA9_1_30891", "HTA9_1_30892", "HTA9_1_30893", "HTA9_1_30894", "HTA9_1_30895", "HTA9_1_30896", "HTA9_1_30897", "HTA9_1_30898", "HTA9_1_30899", "HTA9_1_30900", "HTA9_1_30901", "HTA9_1_30902", "HTA9_1_30903", "HTA9_1_30904", "HTA9_1_30905", "HTA9_1_30906", "HTA9_1_30907", "HTA9_1_30908", "HTA9_1_30909", "HTA9_1_30910", "HTA9_1_30911", "HTA9_1_30912", "HTA9_1_30913", "HTA9_1_30914", "HTA9_1_30915", "HTA9_1_30916", "HTA9_1_30917", "HTA9_1_30918", "HTA9_1_30919", "HTA9_1_30920", "HTA9_1_30921", "HTA9_1_30922", "HTA9_1_30923", "HTA9_1_30924", "HTA9_1_30925", "HTA9_1_30926", "HTA9_1_30927", "HTA9_1_30928", "HTA9_1_30929", "HTA9_1_30930", "HTA9_1_30931", "HTA9_1_30932", "HTA9_1_30933", "HTA9_1_30934", "HTA9_1_30935", "HTA9_1_30936", "HTA9_1_30937", "HTA9_1_30938", "HTA9_1_30939", "HTA9_1_30940", "HTA9_1_30941", "HTA9_1_30942", "HTA9_1_30943", "HTA9_1_30944", "HTA9_1_30945", "HTA9_1_30946", "HTA9_1_30947", "HTA9_1_30948", "HTA9_1_30949", "HTA9_1_30950", "HTA9_1_30951", "HTA9_1_30952", "HTA9_1_30953", "HTA9_1_30954", "HTA9_1_30955", "HTA9_1_30956", "HTA9_1_30957", "HTA9_1_30958", "HTA9_1_30959", "HTA9_1_30960", "HTA9_1_30961", "HTA9_1_30962", "HTA9_1_30963", "HTA9_1_30964", "HTA9_1_30965", "HTA9_1_30966", "HTA9_1_30967", "HTA9_1_30968", "HTA9_1_30969", "HTA9_1_30970", "HTA9_1_30971", "HTA9_1_30972", "HTA9_1_30973", "HTA9_1_30974", "HTA9_1_30975", "HTA9_1_30976", "HTA9_1_30977", "HTA9_1_30978", "HTA9_1_30979", "HTA9_1_30980", "HTA9_1_30981", "HTA9_1_30982", "HTA9_1_30983", "HTA9_1_30984", "HTA9_1_30985", "HTA9_1_30986", "HTA9_1_30987", "HTA9_1_30988", "HTA9_1_30989", "HTA9_1_30990", "HTA9_1_30991", "HTA9_1_30992", "HTA9_1_30993", "HTA9_1_30994", "HTA9_1_30995", "HTA9_1_30996", "HTA9_1_30997", "HTA9_1_30998", "HTA9_1_30999", "HTA9_1_31000", "HTA9_1_31001", "HTA9_1_31002", "HTA9_1_31003", "HTA9_1_31004", "HTA9_1_31005", "HTA9_1_31006", "HTA9_1_31007", "HTA9_1_31008", "HTA9_1_31009", "HTA9_1_31010", "HTA9_1_31011", "HTA9_1_31012", "HTA9_1_31013", "HTA9_1_31014", "HTA9_1_31015", "HTA9_1_31016", "HTA9_1_31017", "HTA9_1_31018", "HTA9_1_31019", "HTA9_1_31020", "HTA9_1_31021", "HTA9_1_31022", "HTA9_1_31023", "HTA9_1_31024", "HTA9_1_31025", "HTA9_1_31026", "HTA9_1_31027", "HTA9_1_31028", "HTA9_1_31029", "HTA9_1_31030", "HTA9_1_31031", "HTA9_1_31032", "HTA9_1_31033", "HTA9_1_31034", "HTA9_1_31035", "HTA9_1_31036", "HTA9_1_31037", "HTA9_1_31038", "HTA9_1_31039", "HTA9_1_31040", "HTA9_1_31041", "HTA9_1_31042", "HTA9_1_31043", "HTA9_1_31044", "HTA9_1_31045", "HTA9_1_31046", "HTA9_1_31047", "HTA9_1_31048", "HTA9_1_31049", "HTA9_1_31050", "HTA9_1_31051", "HTA9_1_31052", "HTA9_1_31053", "HTA9_1_31054", "HTA9_1_31055", "HTA9_1_31056", "HTA9_1_31057", "HTA9_1_31058", "HTA9_1_31059", "HTA9_1_31060", "HTA9_1_31061", "HTA9_1_31062", "HTA9_1_31063", "HTA9_1_31064", "HTA9_1_31065", "HTA9_1_31066", "HTA9_1_31067", "HTA9_1_31068", "HTA9_1_31069", "HTA9_1_31070", "HTA9_1_31071", "HTA9_1_31072", "HTA9_1_31073", "HTA9_1_31074", "HTA9_1_31075", "HTA9_1_31076", "HTA9_1_31077", "HTA9_1_31078", "HTA9_1_31079", "HTA9_1_31080", "HTA9_1_31081", "HTA9_1_31082", "HTA9_1_31083", "HTA9_1_31084", "HTA9_1_31085", "HTA9_1_31086", "HTA9_1_31087", "HTA9_1_31088", "HTA9_1_31089", "HTA9_1_31090", "HTA9_1_31091", "HTA9_1_31092", "HTA9_1_31093", "HTA9_1_31094", "HTA9_1_31095", "HTA9_1_31096", "HTA9_1_31097", "HTA9_1_31098", "HTA9_1_31099", "HTA9_1_31100", "HTA9_1_31101", "HTA9_1_31102", "HTA9_1_31103", "HTA9_1_31104", "HTA9_1_31105", "HTA9_1_31106", "HTA9_1_31107", "HTA9_1_31108", "HTA9_1_31109", "HTA9_1_31110", "HTA9_1_31111", "HTA9_1_31112", "HTA9_1_31113", "HTA9_1_31114", "HTA9_1_31115", "HTA9_1_31116", "HTA9_1_31117", "HTA9_1_31118", "HTA9_1_31119", "HTA9_1_31120", "HTA9_1_31121", "HTA9_1_31122", "HTA9_1_31123", "HTA9_1_31124", "HTA9_1_31125", "HTA9_1_31126", "HTA9_1_31127", "HTA9_1_31128", "HTA9_1_31129", "HTA9_1_31130", "HTA9_1_31131", "HTA9_1_31132", "HTA9_1_31133", "HTA9_1_31134", "HTA9_1_31135", "HTA9_1_31136", "HTA9_1_31137", "HTA9_1_31138", "HTA9_1_31139", "HTA9_1_31140", "HTA9_1_31141", "HTA9_1_31142", "HTA9_1_31143", "HTA9_1_31144", "HTA9_1_31145", "HTA9_1_31146", "HTA9_1_31147", "HTA9_1_31148", "HTA9_1_31149", "HTA9_1_31150", "HTA9_1_31151", "HTA9_1_31152", "HTA9_1_31153", "HTA9_1_31154", "HTA9_1_31155", "HTA9_1_31156", "HTA9_1_31157", "HTA9_1_31158", "HTA9_1_31159", "HTA9_1_31160", "HTA9_1_31161", "HTA9_1_31162", "HTA9_1_31163", "HTA9_1_31164", "HTA9_1_31165", "HTA9_1_31166", "HTA9_1_31167", "HTA9_1_31168", "HTA9_1_31169", "HTA9_1_31170", "HTA9_1_31171", "HTA9_1_31172", "HTA9_1_31173", "HTA9_1_31174", "HTA9_1_31175", "HTA9_1_31176", "HTA9_1_31177", "HTA9_1_31178", "HTA9_1_31179", "HTA9_1_31180", "HTA9_1_31181", "HTA9_1_31182", "HTA9_1_31183", "HTA9_1_31184", "HTA9_1_31185", "HTA9_1_31186", "HTA9_1_31187", "HTA9_1_31188", "HTA9_1_31189", "HTA9_1_31190", "HTA9_1_31191", "HTA9_1_31192", "HTA9_1_31193", "HTA9_1_31194", "HTA9_1_31195", "HTA9_1_31196", "HTA9_1_31197", "HTA9_1_31198", "HTA9_1_31199", "HTA9_1_31200", "HTA9_1_31201", "HTA9_1_31202", "HTA9_1_31203", "HTA9_1_31204", "HTA9_1_31205", "HTA9_1_31206", "HTA9_1_31207", "HTA9_1_31208", "HTA9_1_31209", "HTA9_1_31210", "HTA9_1_31211", "HTA9_1_31212", "HTA9_1_31213", "HTA9_1_31214", "HTA9_1_31215", "HTA9_1_31216", "HTA9_1_31217", "HTA9_1_31218", "HTA9_1_31219", "HTA9_1_31220", "HTA9_1_31221", "HTA9_1_31222", "HTA9_1_31223", "HTA9_1_31224", "HTA9_1_31225", "HTA9_1_31226", "HTA9_1_31227", "HTA9_1_31228", "HTA9_1_31229", "HTA9_1_31230", "HTA9_1_31231", "HTA9_1_31232", "HTA9_1_31233", "HTA9_1_31234", "HTA9_1_31235", "HTA9_1_31236", "HTA9_1_31237", "HTA9_1_31238", "HTA9_1_31239", "HTA9_1_31240", "HTA9_1_31241", "HTA9_1_31242", "HTA9_1_31243", "HTA9_1_31244", "HTA9_1_31245", "HTA9_1_31246", "HTA9_1_31247", "HTA9_1_31248", "HTA9_1_31249", "HTA9_1_31250", "HTA9_1_31251", "HTA9_1_31252", "HTA9_1_31253", "HTA9_1_31254", "HTA9_1_31255", "HTA9_1_31256", "HTA9_1_31257", "HTA9_1_31258", "HTA9_1_31259", "HTA9_1_31260", "HTA9_1_31261", "HTA9_1_31262", "HTA9_1_31263", "HTA9_1_31264", "HTA9_1_31265", "HTA9_1_31266", "HTA9_1_31267", "HTA9_1_31268", "HTA9_1_31269", "HTA9_1_31270", "HTA9_1_31271", "HTA9_1_31272", "HTA9_1_31273", "HTA9_1_31274", "HTA9_1_31275", "HTA9_1_31276", "HTA9_1_31277", "HTA9_1_31278", "HTA9_1_31279", "HTA9_1_31280", "HTA9_1_31281", "HTA9_1_31282", "HTA9_1_31283", "HTA9_1_31284", "HTA9_1_31285", "HTA9_1_31286", "HTA9_1_31287", "HTA9_1_31288", "HTA9_1_31289", "HTA9_1_31290", "HTA9_1_31291", "HTA9_1_31292", "HTA9_1_31293", "HTA9_1_31294", "HTA9_1_31295", "HTA9_1_31296", "HTA9_1_31297", "HTA9_1_31298", "HTA9_1_31299", "HTA9_1_31300", "HTA9_1_31301", "HTA9_1_31302", "HTA9_1_31303", "HTA9_1_31304", "HTA9_1_31305", "HTA9_1_31306", "HTA9_1_31307", "HTA9_1_31308", "HTA9_1_31309", "HTA9_1_31310", "HTA9_1_31311", "HTA9_1_31312", "HTA9_1_31313", "HTA9_1_31314", "HTA9_1_31315", "HTA9_1_31316", "HTA9_1_31317", "HTA9_1_31318", "HTA9_1_31319", "HTA9_1_31320", "HTA9_1_31321", "HTA9_1_31322", "HTA9_1_31323", "HTA9_1_31324", "HTA9_1_31325", "HTA9_1_31326", "HTA9_1_31327", "HTA9_1_31328", "HTA9_1_31329", "HTA9_1_31330", "HTA9_1_31331", "HTA9_1_31332", "HTA9_1_31333", "HTA9_1_31334", "HTA9_1_31335", "HTA9_1_31336", "HTA9_1_31337", "HTA9_1_31338", "HTA9_1_31339", "HTA9_1_31340", "HTA9_1_31341", "HTA9_1_31342", "HTA9_1_31343", "HTA9_1_31344", "HTA9_1_31345", "HTA9_1_31346", "HTA9_1_31347", "HTA9_1_31348", "HTA9_1_31349", "HTA9_1_31350", "HTA9_1_31351", "HTA9_1_31352", "HTA9_1_31353", "HTA9_1_31354", "HTA9_1_31355", "HTA9_1_31356", "HTA9_1_31357", "HTA9_1_31358", "HTA9_1_31359", "HTA9_1_31360", "HTA9_1_31361", "HTA9_1_31362", "HTA9_1_31363", "HTA9_1_31364", "HTA9_1_31365", "HTA9_1_31366", "HTA9_1_31367", "HTA9_1_31368", "HTA9_1_31369", "HTA9_1_31370", "HTA9_1_31371", "HTA9_1_31372", "HTA9_1_31373", "HTA9_1_31374", "HTA9_1_31375", "HTA9_1_31376", "HTA9_1_31377", "HTA9_1_31378", "HTA9_1_31379", "HTA9_1_31380", "HTA9_1_31381", "HTA9_1_31382", "HTA9_1_31383", "HTA9_1_31384", "HTA9_1_31385", "HTA9_1_31386", "HTA9_1_31387", "HTA9_1_31388", "HTA9_1_31389", "HTA9_1_31390", "HTA9_1_31391", "HTA9_1_31392", "HTA9_1_31393", "HTA9_1_31394", "HTA9_1_31395", "HTA9_1_31396", "HTA9_1_31397", "HTA9_1_31398", "HTA9_1_31399", "HTA9_1_31400", "HTA9_1_31401", "HTA9_1_31402", "HTA9_1_31403", "HTA9_1_31404", "HTA9_1_31405", "HTA9_1_31406", "HTA9_1_31407", "HTA9_1_31408", "HTA9_1_31409", "HTA9_1_31410", "HTA9_1_31411", "HTA9_1_31412", "HTA9_1_31413", "HTA9_1_31414", "HTA9_1_31415", "HTA9_1_31416", "HTA9_1_31417", "HTA9_1_31418", "HTA9_1_31419", "HTA9_1_31420", "HTA9_1_31421", "HTA9_1_31422", "HTA9_1_31423", "HTA9_1_31424", "HTA9_1_31425", "HTA9_1_31426", "HTA9_1_31427", "HTA9_1_31428", "HTA9_1_31429", "HTA9_1_31430", "HTA9_1_31431", "HTA9_1_31432", "HTA9_1_31433", "HTA9_1_31434", "HTA9_1_31435", "HTA9_1_31436", "HTA9_1_31437", "HTA9_1_31438", "HTA9_1_31439", "HTA9_1_31440", "HTA9_1_31441", "HTA9_1_31442", "HTA9_1_31443", "HTA9_1_31444", "HTA9_1_31445", "HTA9_1_31446", "HTA9_1_31447", "HTA9_1_31448", "HTA9_1_31449", "HTA9_1_31450", "HTA9_1_31451", "HTA9_1_31452", "HTA9_1_31453", "HTA9_1_31454", "HTA9_1_31455", "HTA9_1_31456", "HTA9_1_31457", "HTA9_1_31458", "HTA9_1_31459", "HTA9_1_31460", "HTA9_1_31461", "HTA9_1_31462", "HTA9_1_31463", "HTA9_1_31464", "HTA9_1_31465", "HTA9_1_31466", "HTA9_1_31467", "HTA9_1_31468", "HTA9_1_31469", "HTA9_1_31470", "HTA9_1_31471", "HTA9_1_31472", "HTA9_1_31473", "HTA9_1_31474", "HTA9_1_31475", "HTA9_1_31476", "HTA9_1_31477", "HTA9_1_31478", "HTA9_1_31479", "HTA9_1_31480", "HTA9_1_31481", "HTA9_1_31482", "HTA9_1_31483", "HTA9_1_31484", "HTA9_1_31485", "HTA9_1_31486", "HTA9_1_31487", "HTA9_1_31488", "HTA9_1_31489", "HTA9_1_31490", "HTA9_1_31491", "HTA9_1_31492", "HTA9_1_31493", "HTA9_1_31494", "HTA9_1_31495", "HTA9_1_31496", "HTA9_1_31497", "HTA9_1_31498", "HTA9_1_31499", "HTA9_1_31500", "HTA9_1_31501", "HTA9_1_31502", "HTA9_1_31503", "HTA9_1_31504", "HTA9_1_31505", "HTA9_1_31506", "HTA9_1_31507", "HTA9_1_31508", "HTA9_1_31509", "HTA9_1_31510", "HTA9_1_31511", "HTA9_1_31512", "HTA9_1_31513", "HTA9_1_31514", "HTA9_1_31515", "HTA9_1_31516", "HTA9_1_31517", "HTA9_1_31518", "HTA9_1_31519", "HTA9_1_31520", "HTA9_1_31521", "HTA9_1_31522", "HTA9_1_31523", "HTA9_1_31524", "HTA9_1_31525", "HTA9_1_31526", "HTA9_1_31527", "HTA9_1_31528", "HTA9_1_31529", "HTA9_1_31530", "HTA9_1_31531", "HTA9_1_31532", "HTA9_1_31533", "HTA9_1_31534", "HTA9_1_31535", "HTA9_1_31536", "HTA9_1_31537", "HTA9_1_31538", "HTA9_1_31539", "HTA9_1_31540", "HTA9_1_31541", "HTA9_1_31542", "HTA9_1_31543", "HTA9_1_31544", "HTA9_1_31545", "HTA9_1_31546", "HTA9_1_31547", "HTA9_1_31548", "HTA9_1_31549", "HTA9_1_31550", "HTA9_1_31551", "HTA9_1_31552", "HTA9_1_31553", "HTA9_1_31554", "HTA9_1_31555", "HTA9_1_31556", "HTA9_1_31557", "HTA9_1_31558", "HTA9_1_31559", "HTA9_1_31560", "HTA9_1_31561", "HTA9_1_31562", "HTA9_1_31563", "HTA9_1_31564", "HTA9_1_31565", "HTA9_1_31566", "HTA9_1_31567", "HTA9_1_31568", "HTA9_1_31569", "HTA9_1_31570", "HTA9_1_31571", "HTA9_1_31572", "HTA9_1_31573", "HTA9_1_31574", "HTA9_1_31575", "HTA9_1_31576", "HTA9_1_31577", "HTA9_1_31578", "HTA9_1_31579", "HTA9_1_31580", "HTA9_1_31581", "HTA9_1_31582", "HTA9_1_31583", "HTA9_1_31584", "HTA9_1_31585", "HTA9_1_31586", "HTA9_1_31587", "HTA9_1_31588", "HTA9_1_31589", "HTA9_1_31590", "HTA9_1_31591", "HTA9_1_31592", "HTA9_1_31593", "HTA9_1_31594", "HTA9_1_31595", "HTA9_1_31596", "HTA9_1_31597", "HTA9_1_31598", "HTA9_1_31599", "HTA9_1_31600", "HTA9_1_31601", "HTA9_1_31602", "HTA9_1_31603", "HTA9_1_31604", "HTA9_1_31605", "HTA9_1_31606", "HTA9_1_31607", "HTA9_1_31608", "HTA9_1_31609", "HTA9_1_31610", "HTA9_1_31611", "HTA9_1_31612", "HTA9_1_31613", "HTA9_1_31614", "HTA9_1_31615", "HTA9_1_31616", "HTA9_1_31617", "HTA9_1_31618", "HTA9_1_31619", "HTA9_1_31620", "HTA9_1_31621", "HTA9_1_31622", "HTA9_1_31623", "HTA9_1_31624", "HTA9_1_31625", "HTA9_1_31626", "HTA9_1_31627", "HTA9_1_31628", "HTA9_1_31629", "HTA9_1_31630", "HTA9_1_31631", "HTA9_1_31632", "HTA9_1_31633", "HTA9_1_31634", "HTA9_1_31635", "HTA9_1_31636", "HTA9_1_31637", "HTA9_1_31638", "HTA9_1_31639", "HTA9_1_31640", "HTA9_1_31641", "HTA9_1_31642", "HTA9_1_31643", "HTA9_1_31644", "HTA9_1_31645", "HTA9_1_31646", "HTA9_1_31647", "HTA9_1_31648", "HTA9_1_31649", "HTA9_1_31650", "HTA9_1_31651", "HTA9_1_31652", "HTA9_1_31653", "HTA9_1_31654", "HTA9_1_31655", "HTA9_1_31656", "HTA9_1_31657", "HTA9_1_31658", "HTA9_1_31659", "HTA9_1_31660", "HTA9_1_31661", "HTA9_1_31662", "HTA9_1_31663", "HTA9_1_31664", "HTA9_1_31665", "HTA9_1_31666", "HTA9_1_31667", "HTA9_1_31668", "HTA9_1_31669", "HTA9_1_31670", "HTA9_1_31671", "HTA9_1_31672", "HTA9_1_31673", "HTA9_1_31674", "HTA9_1_31675", "HTA9_1_31676", "HTA9_1_31677", "HTA9_1_31678", "HTA9_1_31679", "HTA9_1_31680", "HTA9_1_31681", "HTA9_1_31682", "HTA9_1_31683", "HTA9_1_31684", "HTA9_1_31685", "HTA9_1_31686", "HTA9_1_31687", "HTA9_1_31688", "HTA9_1_31689", "HTA9_1_31690", "HTA9_1_31691", "HTA9_1_31692", "HTA9_1_31693", "HTA9_1_31694", "HTA9_1_31695", "HTA9_1_31696", "HTA9_1_31697", "HTA9_1_31698", "HTA9_1_31699", "HTA9_1_31700", "HTA9_1_31701", "HTA9_1_31702", "HTA9_1_31703", "HTA9_1_31704", "HTA9_1_31705", "HTA9_1_31706", "HTA9_1_31707", "HTA9_1_31708", "HTA9_1_31709", "HTA9_1_31710", "HTA9_1_31711", "HTA9_1_31712", "HTA9_1_31713", "HTA9_1_31714", "HTA9_1_31715", "HTA9_1_31716", "HTA9_1_31717", "HTA9_1_31718", "HTA9_1_31719", "HTA9_1_31720", "HTA9_1_31721", "HTA9_1_31722", "HTA9_1_31723", "HTA9_1_31724", "HTA9_1_31725", "HTA9_1_31726", "HTA9_1_31727", "HTA9_1_31728", "HTA9_1_31729", "HTA9_1_31730", "HTA9_1_31731", "HTA9_1_31732", "HTA9_1_31733", "HTA9_1_31734", "HTA9_1_31735", "HTA9_1_31736", "HTA9_1_31737", "HTA9_1_31738", "HTA9_1_31739", "HTA9_1_31740", "HTA9_1_31741", "HTA9_1_31742", "HTA9_1_31743", "HTA9_1_31744", "HTA9_1_31745", "HTA9_1_31746", "HTA9_1_31747", "HTA9_1_31748", "HTA9_1_31749", "HTA9_1_31750", "HTA9_1_31751", "HTA9_1_31752", "HTA9_1_31753", "HTA9_1_31754", "HTA9_1_31755", "HTA9_1_31756", "HTA9_1_31757", "HTA9_1_31758", "HTA9_1_31759", "HTA9_1_31760", "HTA9_1_31761", "HTA9_1_31762", "HTA9_1_31763", "HTA9_1_31764", "HTA9_1_31765", "HTA9_1_31766", "HTA9_1_31767", "HTA9_1_31768", "HTA9_1_31769", "HTA9_1_31770", "HTA9_1_31771", "HTA9_1_31772", "HTA9_1_31773", "HTA9_1_31774", "HTA9_1_31775", "HTA9_1_31776", "HTA9_1_31777", "HTA9_1_31778", "HTA9_1_31779", "HTA9_1_31780", "HTA9_1_31781", "HTA9_1_31782", "HTA9_1_31783", "HTA9_1_31784", "HTA9_1_31785", "HTA9_1_31786", "HTA9_1_31787", "HTA9_1_31788", "HTA9_1_31789", "HTA9_1_31790", "HTA9_1_31791", "HTA9_1_31792", "HTA9_1_31793", "HTA9_1_31794", "HTA9_1_31795", "HTA9_1_31796", "HTA9_1_31797", "HTA9_1_31798", "HTA9_1_31799", "HTA9_1_31800", "HTA9_1_31801", "HTA9_1_31802", "HTA9_1_31803", "HTA9_1_31804", "HTA9_1_31805", "HTA9_1_31806", "HTA9_1_31807", "HTA9_1_31808", "HTA9_1_31809", "HTA9_1_31810", "HTA9_1_31811", "HTA9_1_31812", "HTA9_1_31813", "HTA9_1_31814", "HTA9_1_31815", "HTA9_1_31816", "HTA9_1_31817", "HTA9_1_31818", "HTA9_1_31819", "HTA9_1_31820", "HTA9_1_31821", "HTA9_1_31822", "HTA9_1_31823", "HTA9_1_31824", "HTA9_1_31825", "HTA9_1_31826", "HTA9_1_31827", "HTA9_1_31828", "HTA9_1_31829", "HTA9_1_31830", "HTA9_1_31831", "HTA9_1_31832", "HTA9_1_31833", "HTA9_1_31834", "HTA9_1_31835", "HTA9_1_31836", "HTA9_1_31837", "HTA9_1_31838", "HTA9_1_31839", "HTA9_1_31840", "HTA9_1_31841", "HTA9_1_31842", "HTA9_1_31843", "HTA9_1_31844", "HTA9_1_31845", "HTA9_1_31846", "HTA9_1_31847", "HTA9_1_31848", "HTA9_1_31849", "HTA9_1_31850", "HTA9_1_31851", "HTA9_1_31852", "HTA9_1_31853", "HTA9_1_31854", "HTA9_1_31855", "HTA9_1_31856", "HTA9_1_31857", "HTA9_1_31858", "HTA9_1_31859", "HTA9_1_31860", "HTA9_1_31861", "HTA9_1_31862", "HTA9_1_31863", "HTA9_1_31864", "HTA9_1_31865", "HTA9_1_31866", "HTA9_1_31867", "HTA9_1_31868", "HTA9_1_31869", "HTA9_1_31870", "HTA9_1_31871", "HTA9_1_31872", "HTA9_1_31873", "HTA9_1_31874", "HTA9_1_31875", "HTA9_1_31876", "HTA9_1_31877", "HTA9_1_31878", "HTA9_1_31879", "HTA9_1_31880", "HTA9_1_31881", "HTA9_1_31882", "HTA9_1_31883", "HTA9_1_31884", "HTA9_1_31885", "HTA9_1_31886", "HTA9_1_31887", "HTA9_1_31888", "HTA9_1_31889", "HTA9_1_31890", "HTA9_1_31891", "HTA9_1_31892", "HTA9_1_31893", "HTA9_1_31894", "HTA9_1_31895", "HTA9_1_31896", "HTA9_1_31897", "HTA9_1_31898", "HTA9_1_31899", "HTA9_1_31900", "HTA9_1_31901", "HTA9_1_31902", "HTA9_1_31903", "HTA9_1_31904", "HTA9_1_31905", "HTA9_1_31906", "HTA9_1_31907", "HTA9_1_31908", "HTA9_1_31909", "HTA9_1_31910", "HTA9_1_31911", "HTA9_1_31912", "HTA9_1_31913", "HTA9_1_31914", "HTA9_1_31915", "HTA9_1_31916", "HTA9_1_31917", "HTA9_1_31918", "HTA9_1_31919", "HTA9_1_31920", "HTA9_1_31921", "HTA9_1_31922", "HTA9_1_31923", "HTA9_1_31924", "HTA9_1_31925", "HTA9_1_31926", "HTA9_1_31927", "HTA9_1_31928", "HTA9_1_31929", "HTA9_1_31930", "HTA9_1_31931", "HTA9_1_31932", "HTA9_1_31933", "HTA9_1_31934", "HTA9_1_31935", "HTA9_1_31936", "HTA9_1_31937", "HTA9_1_31938", "HTA9_1_31939", "HTA9_1_31940", "HTA9_1_31941", "HTA9_1_31942", "HTA9_1_31943", "HTA9_1_31944", "HTA9_1_31945", "HTA9_1_31946", "HTA9_1_31947", "HTA9_1_31948", "HTA9_1_31949", "HTA9_1_31950", "HTA9_1_31951", "HTA9_1_31952", "HTA9_1_31953", "HTA9_1_31954", "HTA9_1_31955", "HTA9_1_31956", "HTA9_1_31957", "HTA9_1_31958", "HTA9_1_31959", "HTA9_1_31960", "HTA9_1_31961", "HTA9_1_31962", "HTA9_1_31963", "HTA9_1_31964", "HTA9_1_31965", "HTA9_1_31966", "HTA9_1_31967", "HTA9_1_31968", "HTA9_1_31969", "HTA9_1_31970", "HTA9_1_31971", "HTA9_1_31972", "HTA9_1_31973", "HTA9_1_31974", "HTA9_1_31975", "HTA9_1_31976", "HTA9_1_31977", "HTA9_1_31978", "HTA9_1_31979", "HTA9_1_31980", "HTA9_1_31981", "HTA9_1_31982", "HTA9_1_31983", "HTA9_1_31984", "HTA9_1_31985", "HTA9_1_31986", "HTA9_1_31987", "HTA9_1_31988", "HTA9_1_31989", "HTA9_1_31990", "HTA9_1_31991", "HTA9_1_31992", "HTA9_1_31993", "HTA9_1_31994", "HTA9_1_31995", "HTA9_1_31996", "HTA9_1_31997", "HTA9_1_31998", "HTA9_1_31999", "HTA9_1_32000", "HTA9_1_32001", "HTA9_1_32002", "HTA9_1_32003", "HTA9_1_32004", "HTA9_1_32005", "HTA9_1_32006", "HTA9_1_32007", "HTA9_1_32008", "HTA9_1_32009", "HTA9_1_32010", "HTA9_1_32011", "HTA9_1_32012", "HTA9_1_32013", "HTA9_1_32014", "HTA9_1_32015", "HTA9_1_32016", "HTA9_1_32017", "HTA9_1_32018", "HTA9_1_32019", "HTA9_1_32020", "HTA9_1_32021", "HTA9_1_32022", "HTA9_1_32023", "HTA9_1_32024", "HTA9_1_32025", "HTA9_1_32026", "HTA9_1_32027", "HTA9_1_32028", "HTA9_1_32029", "HTA9_1_32030", "HTA9_1_32031", "HTA9_1_32032", "HTA9_1_32033", "HTA9_1_32034", "HTA9_1_32035", "HTA9_1_32036", "HTA9_1_32037", "HTA9_1_32038", "HTA9_1_32039", "HTA9_1_32040", "HTA9_1_32041", "HTA9_1_32042", "HTA9_1_32043", "HTA9_1_32044", "HTA9_1_32045", "HTA9_1_32046", "HTA9_1_32047", "HTA9_1_32048", "HTA9_1_32049", "HTA9_1_32050", "HTA9_1_32051", "HTA9_1_32052", "HTA9_1_32053", "HTA9_1_32054", "HTA9_1_32055", "HTA9_1_32056", "HTA9_1_32057", "HTA9_1_32058", "HTA9_1_32059", "HTA9_1_32060", "HTA9_1_32061", "HTA9_1_32062", "HTA9_1_32063", "HTA9_1_32064", "HTA9_1_32065", "HTA9_1_32066", "HTA9_1_32067", "HTA9_1_32068", "HTA9_1_32069", "HTA9_1_32070", "HTA9_1_32071", "HTA9_1_32072", "HTA9_1_32073", "HTA9_1_32074", "HTA9_1_32075", "HTA9_1_32076", "HTA9_1_32077", "HTA9_1_32078", "HTA9_1_32079", "HTA9_1_32080", "HTA9_1_32081", "HTA9_1_32082", "HTA9_1_32083", "HTA9_1_32084", "HTA9_1_32085", "HTA9_1_32086", "HTA9_1_32087", "HTA9_1_32088", "HTA9_1_32089", "HTA9_1_32090", "HTA9_1_32091", "HTA9_1_32092", "HTA9_1_32093", "HTA9_1_32094", "HTA9_1_32095", "HTA9_1_32096", "HTA9_1_32097", "HTA9_1_32098", "HTA9_1_32099", "HTA9_1_32100", "HTA9_1_32101", "HTA9_1_32102", "HTA9_1_32103", "HTA9_1_32104", "HTA9_1_32105", "HTA9_1_32106", "HTA9_1_32107", "HTA9_1_32108", "HTA9_1_32109", "HTA9_1_32110", "HTA9_1_32111", "HTA9_1_32112", "HTA9_1_32113", "HTA9_1_32114", "HTA9_1_32115", "HTA9_1_32116", "HTA9_1_32117", "HTA9_1_32118", "HTA9_1_32119", "HTA9_1_32120", "HTA9_1_32121", "HTA9_1_32122", "HTA9_1_32123", "HTA9_1_32124", "HTA9_1_32125", "HTA9_1_32126", "HTA9_1_32127", "HTA9_1_32128", "HTA9_1_32129", "HTA9_1_32130", "HTA9_1_32131", "HTA9_1_32132", "HTA9_1_32133", "HTA9_1_32134", "HTA9_1_32135", "HTA9_1_32136", "HTA9_1_32137", "HTA9_1_32138", "HTA9_1_32139", "HTA9_1_32140", "HTA9_1_32141", "HTA9_1_32142", "HTA9_1_32143", "HTA9_1_32144", "HTA9_1_32145", "HTA9_1_32146", "HTA9_1_32147", "HTA9_1_32148", "HTA9_1_32149", "HTA9_1_32150", "HTA9_1_32151", "HTA9_1_32152", "HTA9_1_32153", "HTA9_1_32154", "HTA9_1_32155", "HTA9_1_32156", "HTA9_1_32157", "HTA9_1_32158", "HTA9_1_32159", "HTA9_1_32160", "HTA9_1_32161", "HTA9_1_32162", "HTA9_1_32163", "HTA9_1_32164", "HTA9_1_32165", "HTA9_1_32166", "HTA9_1_32167", "HTA9_1_32168", "HTA9_1_32169", "HTA9_1_32170", "HTA9_1_32171", "HTA9_1_32172", "HTA9_1_32173", "HTA9_1_32174", "HTA9_1_32175", "HTA9_1_32176", "HTA9_1_32177", "HTA9_1_32178", "HTA9_1_32179", "HTA9_1_32180", "HTA9_1_32181", "HTA9_1_32182", "HTA9_1_32183", "HTA9_1_32184", "HTA9_1_32185", "HTA9_1_32186", "HTA9_1_32187", "HTA9_1_32188", "HTA9_1_32189", "HTA9_1_32190", "HTA9_1_32191", "HTA9_1_32192", "HTA9_1_32193", "HTA9_1_32194", "HTA9_1_32195", "HTA9_1_32196", "HTA9_1_32197", "HTA9_1_32198", "HTA9_1_32199", "HTA9_1_32200", "HTA9_1_32201", "HTA9_1_32202", "HTA9_1_32203", "HTA9_1_32204", "HTA9_1_32205", "HTA9_1_32206", "HTA9_1_32207", "HTA9_1_32208", "HTA9_1_32209", "HTA9_1_32210", "HTA9_1_32211", "HTA9_1_32212", "HTA9_1_32213", "HTA9_1_32214", "HTA9_1_32215", "HTA9_1_32216", "HTA9_1_32217", "HTA9_1_32218", "HTA9_1_32219", "HTA9_1_32220", "HTA9_1_32221", "HTA9_1_32222", "HTA9_1_32223", "HTA9_1_32224", "HTA9_1_32225", "HTA9_1_32226", "HTA9_1_32227", "HTA9_1_32228", "HTA9_1_32229", "HTA9_1_32230", "HTA9_1_32231", "HTA9_1_32232", "HTA9_1_32233", "HTA9_1_32234", "HTA9_1_32235", "HTA9_1_32236", "HTA9_1_32237", "HTA9_1_32238", "HTA9_1_32239", "HTA9_1_32240", "HTA9_1_32241", "HTA9_1_32242", "HTA9_1_32243", "HTA9_1_32244", "HTA9_1_32245", "HTA9_1_32246", "HTA9_1_32247", "HTA9_1_32248", "HTA9_1_32249", "HTA9_1_32250", "HTA9_1_32251", "HTA9_1_32252", "HTA9_1_32253", "HTA9_1_32254", "HTA9_1_32255", "HTA9_1_32256", "HTA9_1_32257", "HTA9_1_32258", "HTA9_1_32259", "HTA9_1_32260", "HTA9_1_32261", "HTA9_1_32262", "HTA9_1_32263", "HTA9_1_32264", "HTA9_1_32265", "HTA9_1_32266", "HTA9_1_32267", "HTA9_1_32268", "HTA9_1_32269", "HTA9_1_32270", "HTA9_1_32271", "HTA9_1_32272", "HTA9_1_32273", "HTA9_1_32274", "HTA9_1_32275", "HTA9_1_32276", "HTA9_1_32277", "HTA9_1_32278", "HTA9_1_32279", "HTA9_1_32280", "HTA9_1_32281", "HTA9_1_32282", "HTA9_1_32283", "HTA9_1_32284", "HTA9_1_32285", "HTA9_1_32286", "HTA9_1_32287", "HTA9_1_32288", "HTA9_1_32289", "HTA9_1_32290", "HTA9_1_32291", "HTA9_1_32292", "HTA9_1_32293", "HTA9_1_32294", "HTA9_1_32295", "HTA9_1_32296", "HTA9_1_32297", "HTA9_1_32298", "HTA9_1_32299", "HTA9_1_32300", "HTA9_1_32301", "HTA9_1_32302", "HTA9_1_32303", "HTA9_1_32304", "HTA9_1_32305", "HTA9_1_32306", "HTA9_1_32307", "HTA9_1_32308", "HTA9_1_32309", "HTA9_1_32310", "HTA9_1_32311", "HTA9_1_32312", "HTA9_1_32313", "HTA9_1_32314", "HTA9_1_32315", "HTA9_1_32316", "HTA9_1_32317", "HTA9_1_32318", "HTA9_1_32319", "HTA9_1_32320", "HTA9_1_32321", "HTA9_1_32322", "HTA9_1_32323", "HTA9_1_32324", "HTA9_1_32325", "HTA9_1_32326", "HTA9_1_32327", "HTA9_1_32328", "HTA9_1_32329", "HTA9_1_32330", "HTA9_1_32331", "HTA9_1_32332", "HTA9_1_32333", "HTA9_1_32334", "HTA9_1_32335", "HTA9_1_32336", "HTA9_1_32337", "HTA9_1_32338", "HTA9_1_32339", "HTA9_1_32340", "HTA9_1_32341", "HTA9_1_32342", "HTA9_1_32343", "HTA9_1_32344", "HTA9_1_32345", "HTA9_1_32346", "HTA9_1_32347", "HTA9_1_32348", "HTA9_1_32349", "HTA9_1_32350", "HTA9_1_32351", "HTA9_1_32352", "HTA9_1_32353", "HTA9_1_32354", "HTA9_1_32355", "HTA9_1_32356", "HTA9_1_32357", "HTA9_1_32358", "HTA9_1_32359", "HTA9_1_32360", "HTA9_1_32361", "HTA9_1_32362", "HTA9_1_32363", "HTA9_1_32364", "HTA9_1_32365", "HTA9_1_32366", "HTA9_1_32367", "HTA9_1_32368", "HTA9_1_32369", "HTA9_1_32370", "HTA9_1_32371", "HTA9_1_32372", "HTA9_1_32373", "HTA9_1_32374", "HTA9_1_32375", "HTA9_1_32376", "HTA9_1_32377", "HTA9_1_32378", "HTA9_1_32379", "HTA9_1_32380", "HTA9_1_32381", "HTA9_1_32382", "HTA9_1_32383", "HTA9_1_32384", "HTA9_1_32385", "HTA9_1_32386", "HTA9_1_32387", "HTA9_1_32388", "HTA9_1_32389", "HTA9_1_32390", "HTA9_1_32391", "HTA9_1_32392", "HTA9_1_32393", "HTA9_1_32394", "HTA9_1_32395", "HTA9_1_32396", "HTA9_1_32397", "HTA9_1_32398", "HTA9_1_32399", "HTA9_1_32400", "HTA9_1_32401", "HTA9_1_32402", "HTA9_1_32403", "HTA9_1_32404", "HTA9_1_32405", "HTA9_1_32406", "HTA9_1_32407", "HTA9_1_32408", "HTA9_1_32409", "HTA9_1_32410", "HTA9_1_32411", "HTA9_1_32412", "HTA9_1_32413", "HTA9_1_32414", "HTA9_1_32415", "HTA9_1_32416", "HTA9_1_32417", "HTA9_1_32418", "HTA9_1_32419", "HTA9_1_32420", "HTA9_1_32421", "HTA9_1_32422", "HTA9_1_32423", "HTA9_1_32424", "HTA9_1_32425", "HTA9_1_32426", "HTA9_1_32427", "HTA9_1_32428", "HTA9_1_32429", "HTA9_1_32430", "HTA9_1_32431", "HTA9_1_32432", "HTA9_1_32433", "HTA9_1_32434", "HTA9_1_32435", "HTA9_1_32436", "HTA9_1_32437", "HTA9_1_32438", "HTA9_1_32439", "HTA9_1_32440", "HTA9_1_32441", "HTA9_1_32442", "HTA9_1_32443", "HTA9_1_32444", "HTA9_1_32445", "HTA9_1_32446", "HTA9_1_32447", "HTA9_1_32448", "HTA9_1_32449", "HTA9_1_32450", "HTA9_1_32451", "HTA9_1_32452", "HTA9_1_32453", "HTA9_1_32454", "HTA9_1_32455", "HTA9_1_32456", "HTA9_1_32457", "HTA9_1_32458", "HTA9_1_32459", "HTA9_1_32460", "HTA9_1_32461", "HTA9_1_32462", "HTA9_1_32463", "HTA9_1_32464", "HTA9_1_32465", "HTA9_1_32466", "HTA9_1_32467", "HTA9_1_32468", "HTA9_1_32469", "HTA9_1_32470", "HTA9_1_32471", "HTA9_1_32472", "HTA9_1_32473", "HTA9_1_32474", "HTA9_1_32475", "HTA9_1_32476", "HTA9_1_32477", "HTA9_1_32478", "HTA9_1_32479", "HTA9_1_32480", "HTA9_1_32481", "HTA9_1_32482", "HTA9_1_32483", "HTA9_1_32484", "HTA9_1_32485", "HTA9_1_32486", "HTA9_1_32487", "HTA9_1_32488", "HTA9_1_32489", "HTA9_1_32490", "HTA9_1_32491", "HTA9_1_32492", "HTA9_1_32493", "HTA9_1_32494", "HTA9_1_32495", "HTA9_1_32496", "HTA9_1_32497", "HTA9_1_32498", "HTA9_1_32499", "HTA9_1_32500", "HTA9_1_32501", "HTA9_1_32502", "HTA9_1_32503", "HTA9_1_32504", "HTA9_1_32505", "HTA9_1_32506", "HTA9_1_32507", "HTA9_1_32508", "HTA9_1_32509", "HTA9_1_32510", "HTA9_1_32511", "HTA9_1_32512", "HTA9_1_32513", "HTA9_1_32514", "HTA9_1_32515", "HTA9_1_32516", "HTA9_1_32517", "HTA9_1_32518", "HTA9_1_32519", "HTA9_1_32520", "HTA9_1_32521", "HTA9_1_32522", "HTA9_1_32523", "HTA9_1_32524", "HTA9_1_32525", "HTA9_1_32526", "HTA9_1_32527", "HTA9_1_32528", "HTA9_1_32529", "HTA9_1_32530", "HTA9_1_32531", "HTA9_1_32532", "HTA9_1_32533", "HTA9_1_32534", "HTA9_1_32535", "HTA9_1_32536", "HTA9_1_32537", "HTA9_1_32538", "HTA9_1_32539", "HTA9_1_32540", "HTA9_1_32541", "HTA9_1_32542", "HTA9_1_32543", "HTA9_1_32544", "HTA9_1_32545", "HTA9_1_32546", "HTA9_1_32547", "HTA9_1_32548", "HTA9_1_32549", "HTA9_1_32550", "HTA9_1_32551", "HTA9_1_32552", "HTA9_1_32553", "HTA9_1_32554", "HTA9_1_32555", "HTA9_1_32556", "HTA9_1_32557", "HTA9_1_32558", "HTA9_1_32559", "HTA9_1_32560", "HTA9_1_32561", "HTA9_1_32562", "HTA9_1_32563", "HTA9_1_32564", "HTA9_1_32565", "HTA9_1_32566", "HTA9_1_32567", "HTA9_1_32568", "HTA9_1_32569", "HTA9_1_32570", "HTA9_1_32571", "HTA9_1_32572", "HTA9_1_32573", "HTA9_1_32574", "HTA9_1_32575", "HTA9_1_32576", "HTA9_1_32577", "HTA9_1_32578", "HTA9_1_32579", "HTA9_1_32580", "HTA9_1_32581", "HTA9_1_32582", "HTA9_1_32583", "HTA9_1_32584", "HTA9_1_32585", "HTA9_1_32586", "HTA9_1_32587", "HTA9_1_32588", "HTA9_1_32589", "HTA9_1_32590", "HTA9_1_32591", "HTA9_1_32592", "HTA9_1_32593", "HTA9_1_32594", "HTA9_1_32595", "HTA9_1_32596", "HTA9_1_32597", "HTA9_1_32598", "HTA9_1_32599", "HTA9_1_32600", "HTA9_1_32601", "HTA9_1_32602", "HTA9_1_32603", "HTA9_1_32604", "HTA9_1_32605", "HTA9_1_32606", "HTA9_1_32607", "HTA9_1_32608", "HTA9_1_32609", "HTA9_1_32610", "HTA9_1_32611", "HTA9_1_32612", "HTA9_1_32613", "HTA9_1_32614", "HTA9_1_32615", "HTA9_1_32616", "HTA9_1_32617", "HTA9_1_32618", "HTA9_1_32619", "HTA9_1_32620", "HTA9_1_32621", "HTA9_1_32622", "HTA9_1_32623", "HTA9_1_32624", "HTA9_1_32625", "HTA9_1_32626", "HTA9_1_32627", "HTA9_1_32628", "HTA9_1_32629", "HTA9_1_32630", "HTA9_1_32631", "HTA9_1_32632", "HTA9_1_32633", "HTA9_1_32634", "HTA9_1_32635", "HTA9_1_32636", "HTA9_1_32637", "HTA9_1_32638", "HTA9_1_32639", "HTA9_1_32640", "HTA9_1_32641", "HTA9_1_32642", "HTA9_1_32643", "HTA9_1_32644", "HTA9_1_32645", "HTA9_1_32646", "HTA9_1_32647", "HTA9_1_32648", "HTA9_1_32649", "HTA9_1_32650", "HTA9_1_32651", "HTA9_1_32652", "HTA9_1_32653", "HTA9_1_32654", "HTA9_1_32655", "HTA9_1_32656", "HTA9_1_32657", "HTA9_1_32658", "HTA9_1_32659", "HTA9_1_32660", "HTA9_1_32661", "HTA9_1_32662", "HTA9_1_32663", "HTA9_1_32664", "HTA9_1_32665", "HTA9_1_32666", "HTA9_1_32667", "HTA9_1_32668", "HTA9_1_32669", "HTA9_1_32670", "HTA9_1_32671", "HTA9_1_32672", "HTA9_1_32673", "HTA9_1_32674", "HTA9_1_32675", "HTA9_1_32676", "HTA9_1_32677", "HTA9_1_32678", "HTA9_1_32679", "HTA9_1_32680", "HTA9_1_32681", "HTA9_1_32682", "HTA9_1_32683", "HTA9_1_32684", "HTA9_1_32685", "HTA9_1_32686", "HTA9_1_32687", "HTA9_1_32688", "HTA9_1_32689", "HTA9_1_32690", "HTA9_1_32691", "HTA9_1_32692", "HTA9_1_32693", "HTA9_1_32694", "HTA9_1_32695", 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"HTA9_1_37483", "HTA9_1_37484", "HTA9_1_37485", "HTA9_1_37486", "HTA9_1_37487", "HTA9_1_37488", "HTA9_1_37489", "HTA9_1_37490", "HTA9_1_37491", "HTA9_1_37492", "HTA9_1_37493", "HTA9_1_37494", "HTA9_1_37495", "HTA9_1_37496", "HTA9_1_37497", "HTA9_1_37498", "HTA9_1_37499", "HTA9_1_37500", "HTA9_1_37501", "HTA9_1_37502", "HTA9_1_37503", "HTA9_1_37504", "HTA9_1_37505", "HTA9_1_37506", "HTA9_1_37507", "HTA9_1_37508", "HTA9_1_37509", "HTA9_1_37510", "HTA9_1_37511", "HTA9_1_37512", "HTA9_1_37513", "HTA9_1_37514", "HTA9_1_37515", "HTA9_1_37516", "HTA9_1_37517", "HTA9_1_37518", "HTA9_1_37519", "HTA9_1_37520", "HTA9_1_37521", "HTA9_1_37522", "HTA9_1_37523", "HTA9_1_37524", "HTA9_1_37525", "HTA9_1_37526", "HTA9_1_37527", "HTA9_1_37528", "HTA9_1_37529", "HTA9_1_37530", "HTA9_1_37531", "HTA9_1_37532", "HTA9_1_37533", "HTA9_1_37534", "HTA9_1_37535", "HTA9_1_37536", "HTA9_1_37537", "HTA9_1_37538", "HTA9_1_37539", "HTA9_1_37540", "HTA9_1_37541", "HTA9_1_37542", "HTA9_1_37543", "HTA9_1_37544", "HTA9_1_37545", "HTA9_1_37546", "HTA9_1_37547", "HTA9_1_37548", "HTA9_1_37549", "HTA9_1_37550", "HTA9_1_37551", "HTA9_1_37552", "HTA9_1_37553", "HTA9_1_37554", "HTA9_1_37555", "HTA9_1_37556", "HTA9_1_37557", "HTA9_1_37558", "HTA9_1_37559", "HTA9_1_37560", "HTA9_1_37561", "HTA9_1_37562", "HTA9_1_37563", "HTA9_1_37564", "HTA9_1_37565", "HTA9_1_37566", "HTA9_1_37567", "HTA9_1_37568", "HTA9_1_37569", "HTA9_1_37570", "HTA9_1_37571", "HTA9_1_37572", "HTA9_1_37573", "HTA9_1_37574", "HTA9_1_37575", "HTA9_1_37576", "HTA9_1_37577", "HTA9_1_37578", "HTA9_1_37579", "HTA9_1_37580", "HTA9_1_37581", "HTA9_1_37582", "HTA9_1_37583", "HTA9_1_37584", "HTA9_1_37585", "HTA9_1_37586", "HTA9_1_37587", "HTA9_1_37588", "HTA9_1_37589", "HTA9_1_37590", "HTA9_1_37591", "HTA9_1_37592", "HTA9_1_37593", "HTA9_1_37594", "HTA9_1_37595", "HTA9_1_37596", "HTA9_1_37597", "HTA9_1_37598", "HTA9_1_37599", "HTA9_1_37600", "HTA9_1_37601", "HTA9_1_37602", "HTA9_1_37603", "HTA9_1_37604", "HTA9_1_37605", "HTA9_1_37606", "HTA9_1_37607", "HTA9_1_37608", "HTA9_1_37609", "HTA9_1_37610", "HTA9_1_37611", "HTA9_1_37612", "HTA9_1_37613", "HTA9_1_37614", "HTA9_1_37615", "HTA9_1_37616", "HTA9_1_37617", "HTA9_1_37618", "HTA9_1_37619", "HTA9_1_37620", "HTA9_1_37621", "HTA9_1_37622", "HTA9_1_37623", "HTA9_1_37624", "HTA9_1_37625", "HTA9_1_37626", "HTA9_1_37627", "HTA9_1_37628", "HTA9_1_37629", "HTA9_1_37630", "HTA9_1_37631", "HTA9_1_37632", "HTA9_1_37633", "HTA9_1_37634", "HTA9_1_37635", "HTA9_1_37636", "HTA9_1_37637", "HTA9_1_37638", "HTA9_1_37639", "HTA9_1_37640", "HTA9_1_37641", "HTA9_1_37642", "HTA9_1_37643", "HTA9_1_37644", "HTA9_1_37645", "HTA9_1_37646", "HTA9_1_37647", "HTA9_1_37648", "HTA9_1_37649", "HTA9_1_37650", "HTA9_1_37651", "HTA9_1_37652", "HTA9_1_37653", "HTA9_1_37654", "HTA9_1_37655", "HTA9_1_37656", "HTA9_1_37657", "HTA9_1_37658", "HTA9_1_37659", "HTA9_1_37660", "HTA9_1_37661", "HTA9_1_37662", "HTA9_1_37663", "HTA9_1_37664", "HTA9_1_37665", "HTA9_1_37666", "HTA9_1_37667", "HTA9_1_37668", "HTA9_1_37669", "HTA9_1_37670", "HTA9_1_37671", "HTA9_1_37672", "HTA9_1_37673", "HTA9_1_37674", "HTA9_1_37675", "HTA9_1_37676", "HTA9_1_37677", "HTA9_1_37678", "HTA9_1_37679", "HTA9_1_37680", "HTA9_1_37681", "HTA9_1_37682", "HTA9_1_37683", "HTA9_1_37684", "HTA9_1_37685", "HTA9_1_37686", "HTA9_1_37687", "HTA9_1_37688", "HTA9_1_37689", "HTA9_1_37690", "HTA9_1_37691", "HTA9_1_37692", "HTA9_1_37693", "HTA9_1_37694", "HTA9_1_37695", "HTA9_1_37696", "HTA9_1_37697", "HTA9_1_37698", "HTA9_1_37699", "HTA9_1_37700", "HTA9_1_37701", "HTA9_1_37702", "HTA9_1_37703", "HTA9_1_37704", "HTA9_1_37705", "HTA9_1_37706", "HTA9_1_37707", "HTA9_1_37708", "HTA9_1_37709", "HTA9_1_37710", "HTA9_1_37711", "HTA9_1_37712", "HTA9_1_37713", "HTA9_1_37714", "HTA9_1_37715", "HTA9_1_37716", "HTA9_1_37717", "HTA9_1_37718", "HTA9_1_37719", "HTA9_1_37720", "HTA9_1_37721", "HTA9_1_37722", "HTA9_1_37723", "HTA9_1_37724", "HTA9_1_37725", "HTA9_1_37726", "HTA9_1_37727", "HTA9_1_37728", "HTA9_1_37729", "HTA9_1_37730", "HTA9_1_37731", "HTA9_1_37732", "HTA9_1_37733", "HTA9_1_37734", "HTA9_1_37735", "HTA9_1_37736", "HTA9_1_37737", "HTA9_1_37738", "HTA9_1_37739", "HTA9_1_37740", "HTA9_1_37741", "HTA9_1_37742", "HTA9_1_37743", "HTA9_1_37744", "HTA9_1_37745", "HTA9_1_37746", "HTA9_1_37747", "HTA9_1_37748", "HTA9_1_37749", "HTA9_1_37750", "HTA9_1_37751", "HTA9_1_37752", "HTA9_1_37753", "HTA9_1_37754", "HTA9_1_37755", "HTA9_1_37756", "HTA9_1_37757", "HTA9_1_37758", "HTA9_1_37759", "HTA9_1_37760", "HTA9_1_37761", "HTA9_1_37762", "HTA9_1_37763", "HTA9_1_37764", "HTA9_1_37765", "HTA9_1_37766", "HTA9_1_37767", "HTA9_1_37768", "HTA9_1_37769", "HTA9_1_37770", "HTA9_1_37771", "HTA9_1_37772", "HTA9_1_37773", "HTA9_1_37774", "HTA9_1_37775", "HTA9_1_37776", "HTA9_1_37777", "HTA9_1_37778", "HTA9_1_37779", "HTA9_1_37780", "HTA9_1_37781", "HTA9_1_37782", "HTA9_1_37783", "HTA9_1_37784", "HTA9_1_37785", "HTA9_1_37786", "HTA9_1_37787", "HTA9_1_37788", "HTA9_1_37789", "HTA9_1_37790", "HTA9_1_37791", "HTA9_1_37792", "HTA9_1_37793", "HTA9_1_37794", "HTA9_1_37795", "HTA9_1_37796", "HTA9_1_37797", "HTA9_1_37798", "HTA9_1_37799", "HTA9_1_37800", "HTA9_1_37801", "HTA9_1_37802", "HTA9_1_37803", "HTA9_1_37804", "HTA9_1_37805", "HTA9_1_37806", "HTA9_1_37807", "HTA9_1_37808", "HTA9_1_37809", "HTA9_1_37810", "HTA9_1_37811", "HTA9_1_37812", "HTA9_1_37813", "HTA9_1_37814", "HTA9_1_37815", "HTA9_1_37816", "HTA9_1_37817", "HTA9_1_37818", "HTA9_1_37819", "HTA9_1_37820", "HTA9_1_37821", "HTA9_1_37822", "HTA9_1_37823", "HTA9_1_37824", "HTA9_1_37825", "HTA9_1_37826", "HTA9_1_37827", "HTA9_1_37828", "HTA9_1_37829", "HTA9_1_37830", "HTA9_1_37831", "HTA9_1_37832", "HTA9_1_37833", "HTA9_1_37834", "HTA9_1_37835", "HTA9_1_37836", "HTA9_1_37837", "HTA9_1_37838", "HTA9_1_37839", "HTA9_1_37840", "HTA9_1_37841", "HTA9_1_37842", "HTA9_1_37843", "HTA9_1_37844", "HTA9_1_37845", "HTA9_1_37846", "HTA9_1_37847", "HTA9_1_37848", "HTA9_1_37849", "HTA9_1_37850", "HTA9_1_37851", "HTA9_1_37852", "HTA9_1_37853", "HTA9_1_37854", "HTA9_1_37855", "HTA9_1_37856", "HTA9_1_37857", "HTA9_1_37858", "HTA9_1_37859", "HTA9_1_37860", "HTA9_1_37861", "HTA9_1_37862", "HTA9_1_37863", "HTA9_1_37864", "HTA9_1_37865", "HTA9_1_37866", "HTA9_1_37867", "HTA9_1_37868", "HTA9_1_37869", "HTA9_1_37870", "HTA9_1_37871", "HTA9_1_37872", "HTA9_1_37873", "HTA9_1_37874", "HTA9_1_37875", "HTA9_1_37876", "HTA9_1_37877", "HTA9_1_37878", "HTA9_1_37879", "HTA9_1_37880", "HTA9_1_37881", "HTA9_1_37882", "HTA9_1_37883", "HTA9_1_37884", "HTA9_1_37885", "HTA9_1_37886", "HTA9_1_37887", "HTA9_1_37888", "HTA9_1_37889", "HTA9_1_37890", "HTA9_1_37891", "HTA9_1_37892", "HTA9_1_37893", "HTA9_1_37894", "HTA9_1_37895", "HTA9_1_37896", "HTA9_1_37897", "HTA9_1_37898", "HTA9_1_37899", "HTA9_1_37900", "HTA9_1_37901", "HTA9_1_37902", "HTA9_1_37903", "HTA9_1_37904", "HTA9_1_37905", "HTA9_1_37906", "HTA9_1_37907", "HTA9_1_37908", "HTA9_1_37909", "HTA9_1_37910", "HTA9_1_37911", "HTA9_1_37912", "HTA9_1_37913", "HTA9_1_37914", "HTA9_1_37915", "HTA9_1_37916", "HTA9_1_37917", "HTA9_1_37918", "HTA9_1_37919", "HTA9_1_37920", "HTA9_1_37921", "HTA9_1_37922", "HTA9_1_37923", "HTA9_1_37924", "HTA9_1_37925", "HTA9_1_37926", "HTA9_1_37927", "HTA9_1_37928", "HTA9_1_37929", "HTA9_1_37930", "HTA9_1_37931", "HTA9_1_37932", "HTA9_1_37933", "HTA9_1_37934", "HTA9_1_37935", "HTA9_1_37936", "HTA9_1_37937", "HTA9_1_37938", "HTA9_1_37939", "HTA9_1_37940", "HTA9_1_37941", "HTA9_1_37942", "HTA9_1_37943", "HTA9_1_37944", "HTA9_1_37945", "HTA9_1_37946", "HTA9_1_37947", "HTA9_1_37948", "HTA9_1_37949", "HTA9_1_37950", "HTA9_1_37951", "HTA9_1_37952", "HTA9_1_37953", "HTA9_1_37954", "HTA9_1_37955", "HTA9_1_37956", "HTA9_1_37957", "HTA9_1_37958", "HTA9_1_37959", "HTA9_1_37960", "HTA9_1_37961", "HTA9_1_37962", "HTA9_1_37963", "HTA9_1_37964", "HTA9_1_37965", "HTA9_1_37966", "HTA9_1_37967", "HTA9_1_37968", "HTA9_1_37969", "HTA9_1_37970", "HTA9_1_37971", "HTA9_1_37972", "HTA9_1_37973", "HTA9_1_37974", "HTA9_1_37975", "HTA9_1_37976", "HTA9_1_37977", "HTA9_1_37978", "HTA9_1_37979", "HTA9_1_37980", "HTA9_1_37981", "HTA9_1_37982", "HTA9_1_37983", "HTA9_1_37984", "HTA9_1_37985", "HTA9_1_37986", "HTA9_1_37987", "HTA9_1_37988", "HTA9_1_37989", "HTA9_1_37990", "HTA9_1_37991", "HTA9_1_37992", "HTA9_1_37993", "HTA9_1_37994", "HTA9_1_37995", "HTA9_1_37996", "HTA9_1_37997", "HTA9_1_37998", "HTA9_1_37999", "HTA9_1_38000", "HTA9_1_38001", "HTA9_1_38002", "HTA9_1_38003", "HTA9_1_38004", "HTA9_1_38005", "HTA9_1_38006", "HTA9_1_38007", "HTA9_1_38008", "HTA9_1_38009", "HTA9_1_38010", "HTA9_1_38011", "HTA9_1_38012", "HTA9_1_38013", "HTA9_1_38014", "HTA9_1_38015", "HTA9_1_38016", "HTA9_1_38017", "HTA9_1_38018", "HTA9_1_38019", "HTA9_1_38020", "HTA9_1_38021", "HTA9_1_38022", "HTA9_1_38023", "HTA9_1_38024", "HTA9_1_38025", "HTA9_1_38026", "HTA9_1_38027", "HTA9_1_38028", "HTA9_1_38029", "HTA9_1_38030", "HTA9_1_38031", "HTA9_1_38032", "HTA9_1_38033", "HTA9_1_38034", "HTA9_1_38035", "HTA9_1_38036", "HTA9_1_38037", "HTA9_1_38038", "HTA9_1_38039", "HTA9_1_38040", "HTA9_1_38041", "HTA9_1_38042", "HTA9_1_38043", "HTA9_1_38044", "HTA9_1_38045", "HTA9_1_38046", "HTA9_1_38047", "HTA9_1_38048", "HTA9_1_38049", "HTA9_1_38050", "HTA9_1_38051", "HTA9_1_38052", "HTA9_1_38053", "HTA9_1_38054", "HTA9_1_38055", "HTA9_1_38056", "HTA9_1_38057", "HTA9_1_38058", "HTA9_1_38059", "HTA9_1_38060", "HTA9_1_38061", "HTA9_1_38062", "HTA9_1_38063", "HTA9_1_38064", "HTA9_1_38065", "HTA9_1_38066", "HTA9_1_38067", "HTA9_1_38068", "HTA9_1_38069", "HTA9_1_38070", "HTA9_1_38071", "HTA9_1_38072", "HTA9_1_38073", "HTA9_1_38074", "HTA9_1_38075", "HTA9_1_38076", "HTA9_1_38077", "HTA9_1_38078", "HTA9_1_38079", "HTA9_1_38080", "HTA9_1_38081", "HTA9_1_38082", "HTA9_1_38083", "HTA9_1_38084", "HTA9_1_38085", "HTA9_1_38086", "HTA9_1_38087", "HTA9_1_38088", "HTA9_1_38089", "HTA9_1_38090", "HTA9_1_38091", "HTA9_1_38092", "HTA9_1_38093", "HTA9_1_38094", "HTA9_1_38095", "HTA9_1_38096", "HTA9_1_38097", "HTA9_1_38098", "HTA9_1_38099", "HTA9_1_38100", "HTA9_1_38101", "HTA9_1_38102", "HTA9_1_38103", "HTA9_1_38104", "HTA9_1_38105", "HTA9_1_38106", "HTA9_1_38107", "HTA9_1_38108", "HTA9_1_38109", "HTA9_1_38110", "HTA9_1_38111", "HTA9_1_38112", "HTA9_1_38113", "HTA9_1_38114", "HTA9_1_38115", "HTA9_1_38116", "HTA9_1_38117", "HTA9_1_38118", "HTA9_1_38119", "HTA9_1_38120", "HTA9_1_38121", "HTA9_1_38122", "HTA9_1_38123", "HTA9_1_38124", "HTA9_1_38125", "HTA9_1_38126", "HTA9_1_38127", "HTA9_1_38128", "HTA9_1_38129", "HTA9_1_38130", "HTA9_1_38131", "HTA9_1_38132", "HTA9_1_38133", "HTA9_1_38134", "HTA9_1_38135", "HTA9_1_38136", "HTA9_1_38137", "HTA9_1_38138", "HTA9_1_38139", "HTA9_1_38140", "HTA9_1_38141", "HTA9_1_38142", "HTA9_1_38143", "HTA9_1_38144", "HTA9_1_38145", "HTA9_1_38146", "HTA9_1_38147", "HTA9_1_38148", "HTA9_1_38149", "HTA9_1_38150", "HTA9_1_38151", "HTA9_1_38152", "HTA9_1_38153", "HTA9_1_38154", "HTA9_1_38155", "HTA9_1_38156", "HTA9_1_38157", "HTA9_1_38158", "HTA9_1_38159", "HTA9_1_38160", "HTA9_1_38161", "HTA9_1_38162", "HTA9_1_38163", "HTA9_1_38164", "HTA9_1_38165", "HTA9_1_38166", "HTA9_1_38167", "HTA9_1_38168", "HTA9_1_38169", "HTA9_1_38170", "HTA9_1_38171", "HTA9_1_38172", "HTA9_1_38173", "HTA9_1_38174", "HTA9_1_38175", "HTA9_1_38176", "HTA9_1_38177", "HTA9_1_38178", "HTA9_1_38179", "HTA9_1_38180", "HTA9_1_38181", "HTA9_1_38182", "HTA9_1_38183", "HTA9_1_38184", "HTA9_1_38185", "HTA9_1_38186", "HTA9_1_38187", "HTA9_1_38188", "HTA9_1_38189", "HTA9_1_38190", "HTA9_1_38191", "HTA9_1_38192", "HTA9_1_38193", "HTA9_1_38194", "HTA9_1_38195", "HTA9_1_38196", "HTA9_1_38197", "HTA9_1_38198", "HTA9_1_38199", "HTA9_1_38200", "HTA9_1_38201", "HTA9_1_38202", "HTA9_1_38203", "HTA9_1_38204", "HTA9_1_38205", "HTA9_1_38206", "HTA9_1_38207", "HTA9_1_38208", "HTA9_1_38209", "HTA9_1_38210", "HTA9_1_38211", "HTA9_1_38212", "HTA9_1_38213", "HTA9_1_38214", "HTA9_1_38215", "HTA9_1_38216", "HTA9_1_38217", "HTA9_1_38218", "HTA9_1_38219", "HTA9_1_38220", "HTA9_1_38221", "HTA9_1_38222", "HTA9_1_38223", "HTA9_1_38224", "HTA9_1_38225", "HTA9_1_38226", "HTA9_1_38227", "HTA9_1_38228", "HTA9_1_38229", "HTA9_1_38230", "HTA9_1_38231", "HTA9_1_38232", "HTA9_1_38233", "HTA9_1_38234", "HTA9_1_38235", "HTA9_1_38236", "HTA9_1_38237", "HTA9_1_38238", "HTA9_1_38239", "HTA9_1_38240", "HTA9_1_38241", "HTA9_1_38242", "HTA9_1_38243", "HTA9_1_38244", "HTA9_1_38245", "HTA9_1_38246", "HTA9_1_38247", "HTA9_1_38248", "HTA9_1_38249", "HTA9_1_38250", "HTA9_1_38251", "HTA9_1_38252", "HTA9_1_38253", "HTA9_1_38254", "HTA9_1_38255", "HTA9_1_38256", "HTA9_1_38257", "HTA9_1_38258", "HTA9_1_38259", "HTA9_1_38260", "HTA9_1_38261", "HTA9_1_38262", "HTA9_1_38263", "HTA9_1_38264", "HTA9_1_38265", "HTA9_1_38266", "HTA9_1_38267", "HTA9_1_38268", "HTA9_1_38269", "HTA9_1_38270", "HTA9_1_38271", "HTA9_1_38272", "HTA9_1_38273", "HTA9_1_38274", "HTA9_1_38275", "HTA9_1_38276", "HTA9_1_38277", "HTA9_1_38278", "HTA9_1_38279", "HTA9_1_38280", "HTA9_1_38281", "HTA9_1_38282", "HTA9_1_38283", "HTA9_1_38284", "HTA9_1_38285", "HTA9_1_38286", "HTA9_1_38287", "HTA9_1_38288", "HTA9_1_38289", "HTA9_1_38290", "HTA9_1_38291", "HTA9_1_38292", "HTA9_1_38293", "HTA9_1_38294", "HTA9_1_38295", "HTA9_1_38296", "HTA9_1_38297", "HTA9_1_38298", "HTA9_1_38299", "HTA9_1_38300", "HTA9_1_38301", "HTA9_1_38302", "HTA9_1_38303", "HTA9_1_38304", "HTA9_1_38305", "HTA9_1_38306", "HTA9_1_38307", "HTA9_1_38308", "HTA9_1_38309", "HTA9_1_38310", "HTA9_1_38311", "HTA9_1_38312", "HTA9_1_38313", "HTA9_1_38314", "HTA9_1_38315", "HTA9_1_38316", "HTA9_1_38317", "HTA9_1_38318", "HTA9_1_38319", "HTA9_1_38320", "HTA9_1_38321", "HTA9_1_38322", "HTA9_1_38323", "HTA9_1_38324", "HTA9_1_38325", "HTA9_1_38326", "HTA9_1_38327", "HTA9_1_38328", "HTA9_1_38329", "HTA9_1_38330", "HTA9_1_38331", "HTA9_1_38332", "HTA9_1_38333", "HTA9_1_38334", "HTA9_1_38335", "HTA9_1_38336", "HTA9_1_38337", "HTA9_1_38338", "HTA9_1_38339", "HTA9_1_38340", "HTA9_1_38341", "HTA9_1_38342", "HTA9_1_38343", "HTA9_1_38344", "HTA9_1_38345", "HTA9_1_38346", "HTA9_1_38347", "HTA9_1_38348", "HTA9_1_38349", "HTA9_1_38350", "HTA9_1_38351", "HTA9_1_38352", "HTA9_1_38353", "HTA9_1_38354", "HTA9_1_38355", "HTA9_1_38356", "HTA9_1_38357", "HTA9_1_38358", "HTA9_1_38359", "HTA9_1_38360", "HTA9_1_38361", "HTA9_1_38362", "HTA9_1_38363", "HTA9_1_38364", "HTA9_1_38365", "HTA9_1_38366", "HTA9_1_38367", "HTA9_1_38368", "HTA9_1_38369", "HTA9_1_38370", "HTA9_1_38371", "HTA9_1_38372", "HTA9_1_38373", "HTA9_1_38374", "HTA9_1_38375", "HTA9_1_38376", "HTA9_1_38377", "HTA9_1_38378", "HTA9_1_38379", "HTA9_1_38380", "HTA9_1_38381", "HTA9_1_38382", "HTA9_1_38383", "HTA9_1_38384", "HTA9_1_38385", "HTA9_1_38386", "HTA9_1_38387", "HTA9_1_38388", "HTA9_1_38389", "HTA9_1_38390", "HTA9_1_38391", "HTA9_1_38392", "HTA9_1_38393", "HTA9_1_38394", "HTA9_1_38395", "HTA9_1_38396", "HTA9_1_38397", "HTA9_1_38398", "HTA9_1_38399", "HTA9_1_38400", "HTA9_1_38401", "HTA9_1_38402", "HTA9_1_38403", "HTA9_1_38404", "HTA9_1_38405", "HTA9_1_38406", "HTA9_1_38407", "HTA9_1_38408", "HTA9_1_38409", "HTA9_1_38410", "HTA9_1_38411", "HTA9_1_38412", "HTA9_1_38413", "HTA9_1_38414", "HTA9_1_38415", "HTA9_1_38416", "HTA9_1_38417", "HTA9_1_38418", "HTA9_1_38419", "HTA9_1_38420", "HTA9_1_38421", "HTA9_1_38422", "HTA9_1_38423", "HTA9_1_38424", "HTA9_1_38425", "HTA9_1_38426", "HTA9_1_38427", "HTA9_1_38428", "HTA9_1_38429", "HTA9_1_38430", "HTA9_1_38431", "HTA9_1_38432", "HTA9_1_38433", "HTA9_1_38434", "HTA9_1_38435", "HTA9_1_38436", "HTA9_1_38437", "HTA9_1_38438", "HTA9_1_38439", "HTA9_1_38440", "HTA9_1_38441", "HTA9_1_38442", "HTA9_1_38443", "HTA9_1_38444", "HTA9_1_38445", "HTA9_1_38446", "HTA9_1_38447", "HTA9_1_38448", "HTA9_1_38449", "HTA9_1_38450", "HTA9_1_38451", "HTA9_1_38452", "HTA9_1_38453", "HTA9_1_38454", "HTA9_1_38455", "HTA9_1_38456", "HTA9_1_38457", "HTA9_1_38458", "HTA9_1_38459", "HTA9_1_38460", "HTA9_1_38461", "HTA9_1_38462", "HTA9_1_38463", "HTA9_1_38464", "HTA9_1_38465", "HTA9_1_38466", "HTA9_1_38467", "HTA9_1_38468", "HTA9_1_38469", "HTA9_1_38470", "HTA9_1_38471", "HTA9_1_38472", "HTA9_1_38473", "HTA9_1_38474", "HTA9_1_38475", "HTA9_1_38476", "HTA9_1_38477", "HTA9_1_38478", "HTA9_1_38479", "HTA9_1_38480", "HTA9_1_38481", "HTA9_1_38482", "HTA9_1_38483", "HTA9_1_38484", "HTA9_1_38485", "HTA9_1_38486", "HTA9_1_38487", "HTA9_1_38488", "HTA9_1_38489", "HTA9_1_38490", "HTA9_1_38491", "HTA9_1_38492", "HTA9_1_38493", "HTA9_1_38494", "HTA9_1_38495", "HTA9_1_38496", "HTA9_1_38497", "HTA9_1_38498", "HTA9_1_38499", "HTA9_1_38500", "HTA9_1_38501", "HTA9_1_38502", "HTA9_1_38503", "HTA9_1_38504", "HTA9_1_38505", "HTA9_1_38506", "HTA9_1_38507", "HTA9_1_38508", "HTA9_1_38509", "HTA9_1_38510", "HTA9_1_38511", "HTA9_1_38512", "HTA9_1_38513", "HTA9_1_38514", "HTA9_1_38515", "HTA9_1_38516", "HTA9_1_38517", "HTA9_1_38518", "HTA9_1_38519", "HTA9_1_38520", "HTA9_1_38521", "HTA9_1_38522", "HTA9_1_38523", "HTA9_1_38524", "HTA9_1_38525", "HTA9_1_38526", "HTA9_1_38527", "HTA9_1_38528", "HTA9_1_38529", "HTA9_1_38530", "HTA9_1_38531", "HTA9_1_38532", "HTA9_1_38533", "HTA9_1_38534", "HTA9_1_38535", "HTA9_1_38536", "HTA9_1_38537", "HTA9_1_38538", "HTA9_1_38539", "HTA9_1_38540", "HTA9_1_38541", "HTA9_1_38542", "HTA9_1_38543", "HTA9_1_38544", "HTA9_1_38545", "HTA9_1_38546", "HTA9_1_38547", "HTA9_1_38548", "HTA9_1_38549", "HTA9_1_38550", "HTA9_1_38551", "HTA9_1_38552", "HTA9_1_38553", "HTA9_1_38554", "HTA9_1_38555", "HTA9_1_38556", "HTA9_1_38557", "HTA9_1_38558", "HTA9_1_38559", "HTA9_1_38560", "HTA9_1_38561", "HTA9_1_38562", "HTA9_1_38563", "HTA9_1_38564", "HTA9_1_38565", "HTA9_1_38566", "HTA9_1_38567", "HTA9_1_38568", "HTA9_1_38569", "HTA9_1_38570", "HTA9_1_38571", "HTA9_1_38572", "HTA9_1_38573", "HTA9_1_38574", "HTA9_1_38575", "HTA9_1_38576", "HTA9_1_38577", "HTA9_1_38578", "HTA9_1_38579", "HTA9_1_38580", "HTA9_1_38581", "HTA9_1_38582", "HTA9_1_38583", "HTA9_1_38584", "HTA9_1_38585", "HTA9_1_38586", "HTA9_1_38587", "HTA9_1_38588", "HTA9_1_38589", "HTA9_1_38590", "HTA9_1_38591", "HTA9_1_38592", "HTA9_1_38593", "HTA9_1_38594", "HTA9_1_38595", "HTA9_1_38596", "HTA9_1_38597", "HTA9_1_38598", "HTA9_1_38599", "HTA9_1_38600", "HTA9_1_38601", "HTA9_1_38602", "HTA9_1_38603", "HTA9_1_38604", "HTA9_1_38605", "HTA9_1_38606", "HTA9_1_38607", "HTA9_1_38608", "HTA9_1_38609", "HTA9_1_38610", "HTA9_1_38611", "HTA9_1_38612", "HTA9_1_38613", "HTA9_1_38614", "HTA9_1_38615", "HTA9_1_38616", "HTA9_1_38617", "HTA9_1_38618", "HTA9_1_38619", "HTA9_1_38620", "HTA9_1_38621", "HTA9_1_38622", "HTA9_1_38623", "HTA9_1_38624", "HTA9_1_38625", "HTA9_1_38626", "HTA9_1_38627", "HTA9_1_38628", "HTA9_1_38629", "HTA9_1_38630", "HTA9_1_38631", "HTA9_1_38632", "HTA9_1_38633", "HTA9_1_38634", "HTA9_1_38635", "HTA9_1_38636", "HTA9_1_38637", "HTA9_1_38638", "HTA9_1_38639", "HTA9_1_38640", "HTA9_1_38641", "HTA9_1_38642", "HTA9_1_38643", "HTA9_1_38644", "HTA9_1_38645", "HTA9_1_38646", "HTA9_1_38647", "HTA9_1_38648", "HTA9_1_38649", "HTA9_1_38650", "HTA9_1_38651", "HTA9_1_38652", "HTA9_1_38653", "HTA9_1_38654", "HTA9_1_38655", "HTA9_1_38656", "HTA9_1_38657", "HTA9_1_38658", "HTA9_1_38659", "HTA9_1_38660", "HTA9_1_38661", "HTA9_1_38662", "HTA9_1_38663", "HTA9_1_38664", "HTA9_1_38665", "HTA9_1_38666", "HTA9_1_38667", "HTA9_1_38668", "HTA9_1_38669", "HTA9_1_38670", "HTA9_1_38671", "HTA9_1_38672", "HTA9_1_38673", "HTA9_1_38674", "HTA9_1_38675", "HTA9_1_38676", "HTA9_1_38677", "HTA9_1_38678", "HTA9_1_38679", "HTA9_1_38680", "HTA9_1_38681", "HTA9_1_38682", "HTA9_1_38683", "HTA9_1_38684", "HTA9_1_38685", "HTA9_1_38686", "HTA9_1_38687", "HTA9_1_38688", "HTA9_1_38689", "HTA9_1_38690", "HTA9_1_38691", "HTA9_1_38692", "HTA9_1_38693", "HTA9_1_38694", "HTA9_1_38695", "HTA9_1_38696", "HTA9_1_38697", "HTA9_1_38698", "HTA9_1_38699", "HTA9_1_38700", "HTA9_1_38701", "HTA9_1_38702", "HTA9_1_38703", "HTA9_1_38704", "HTA9_1_38705", "HTA9_1_38706", "HTA9_1_38707", "HTA9_1_38708", "HTA9_1_38709", "HTA9_1_38710", "HTA9_1_38711", "HTA9_1_38712", "HTA9_1_38713", "HTA9_1_38714", "HTA9_1_38715", "HTA9_1_38716", "HTA9_1_38717", "HTA9_1_38718", "HTA9_1_38719", "HTA9_1_38720", "HTA9_1_38721", "HTA9_1_38722", "HTA9_1_38723", "HTA9_1_38724", "HTA9_1_38725", "HTA9_1_38726", "HTA9_1_38727", "HTA9_1_38728", "HTA9_1_38729", "HTA9_1_38730", "HTA9_1_38731", "HTA9_1_38732", "HTA9_1_38733", "HTA9_1_38734", "HTA9_1_38735", "HTA9_1_38736", "HTA9_1_38737", "HTA9_1_38738", "HTA9_1_38739", "HTA9_1_38740", "HTA9_1_38741", "HTA9_1_38742", "HTA9_1_38743", "HTA9_1_38744", "HTA9_1_38745", "HTA9_1_38746", "HTA9_1_38747", "HTA9_1_38748", "HTA9_1_38749", "HTA9_1_38750", "HTA9_1_38751", "HTA9_1_38752", "HTA9_1_38753", "HTA9_1_38754", "HTA9_1_38755", "HTA9_1_38756", "HTA9_1_38757", "HTA9_1_38758", "HTA9_1_38759", "HTA9_1_38760", "HTA9_1_38761", "HTA9_1_38762", "HTA9_1_38763", "HTA9_1_38764", "HTA9_1_38765", "HTA9_1_38766", "HTA9_1_38767", "HTA9_1_38768", "HTA9_1_38769", "HTA9_1_38770", "HTA9_1_38771", "HTA9_1_38772", "HTA9_1_38773", "HTA9_1_38774", "HTA9_1_38775", "HTA9_1_38776", "HTA9_1_38777", "HTA9_1_38778", "HTA9_1_38779", "HTA9_1_38780", "HTA9_1_38781", "HTA9_1_38782", "HTA9_1_38783", "HTA9_1_38784", "HTA9_1_38785", "HTA9_1_38786", "HTA9_1_38787", "HTA9_1_38788", "HTA9_1_38789", "HTA9_1_38790", "HTA9_1_38791", "HTA9_1_38792", "HTA9_1_38793", "HTA9_1_38794", "HTA9_1_38795", "HTA9_1_38796", "HTA9_1_38797", "HTA9_1_38798", "HTA9_1_38799", "HTA9_1_38800", "HTA9_1_38801", "HTA9_1_38802", "HTA9_1_38803", "HTA9_1_38804", "HTA9_1_38805", "HTA9_1_38806", "HTA9_1_38807", "HTA9_1_38808", "HTA9_1_38809", "HTA9_1_38810", "HTA9_1_38811", "HTA9_1_38812", "HTA9_1_38813", "HTA9_1_38814", "HTA9_1_38815", "HTA9_1_38816", "HTA9_1_38817", "HTA9_1_38818", "HTA9_1_38819", "HTA9_1_38820", "HTA9_1_38821", "HTA9_1_38822", "HTA9_1_38823", "HTA9_1_38824", "HTA9_1_38825", "HTA9_1_38826", "HTA9_1_38827", "HTA9_1_38828", "HTA9_1_38829", "HTA9_1_38830", "HTA9_1_38831", "HTA9_1_38832", "HTA9_1_38833", "HTA9_1_38834", "HTA9_1_38835", "HTA9_1_38836", "HTA9_1_38837", "HTA9_1_38838", "HTA9_1_38839", "HTA9_1_38840", "HTA9_1_38841", "HTA9_1_38842", "HTA9_1_38843", "HTA9_1_38844", "HTA9_1_38845", "HTA9_1_38846", 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"HTA9_1_39157", "HTA9_1_39158", "HTA9_1_39159", "HTA9_1_39160", "HTA9_1_39161", "HTA9_1_39162", "HTA9_1_39163", "HTA9_1_39164", "HTA9_1_39165", "HTA9_1_39166", "HTA9_1_39167", "HTA9_1_39168", "HTA9_1_39169", "HTA9_1_39170", "HTA9_1_39171", "HTA9_1_39172", "HTA9_1_39173", "HTA9_1_39174", "HTA9_1_39175", "HTA9_1_39176", "HTA9_1_39177", "HTA9_1_39178", "HTA9_1_39179", "HTA9_1_39180", "HTA9_1_39181", "HTA9_1_39182", "HTA9_1_39183", "HTA9_1_39184", "HTA9_1_39185", "HTA9_1_39186", "HTA9_1_39187", "HTA9_1_39188", "HTA9_1_39189", "HTA9_1_39190", "HTA9_1_39191", "HTA9_1_39192", "HTA9_1_39193", "HTA9_1_39194", "HTA9_1_39195", "HTA9_1_39196", "HTA9_1_39197", "HTA9_1_39198", "HTA9_1_39199", "HTA9_1_39200", "HTA9_1_39201", "HTA9_1_39202", "HTA9_1_39203", "HTA9_1_39204", "HTA9_1_39205", "HTA9_1_39206", "HTA9_1_39207", "HTA9_1_39208", "HTA9_1_39209", "HTA9_1_39210", "HTA9_1_39211", "HTA9_1_39212", "HTA9_1_39213", "HTA9_1_39214", "HTA9_1_39215", "HTA9_1_39216", "HTA9_1_39217", "HTA9_1_39218", "HTA9_1_39219", "HTA9_1_39220", "HTA9_1_39221", "HTA9_1_39222", "HTA9_1_39223", "HTA9_1_39224", "HTA9_1_39225", "HTA9_1_39226", "HTA9_1_39227", "HTA9_1_39228", "HTA9_1_39229", "HTA9_1_39230", "HTA9_1_39231", "HTA9_1_39232", "HTA9_1_39233", "HTA9_1_39234", "HTA9_1_39236", "HTA9_1_39237", "HTA9_1_39238", "HTA9_1_39239", "HTA9_1_39240", "HTA9_1_39241", "HTA9_1_39242", "HTA9_1_39243", "HTA9_1_39244", "HTA9_1_39245", "HTA9_1_39246", "HTA9_1_39247", "HTA9_1_39248", "HTA9_1_39249", "HTA9_1_39250", "HTA9_1_39251", "HTA9_1_39252", "HTA9_1_39253", "HTA9_1_39254", "HTA9_1_39255", "HTA9_1_39256", "HTA9_1_39257", "HTA9_1_39258", "HTA9_1_39259", "HTA9_1_39260", "HTA9_1_39261", "HTA9_1_39262", "HTA9_1_39263", "HTA9_1_39264", "HTA9_1_39265", "HTA9_1_39266", "HTA9_1_39267", "HTA9_1_39268", "HTA9_1_39269", "HTA9_1_39270", "HTA9_1_39271", "HTA9_1_39272", "HTA9_1_39273", "HTA9_1_39274", "HTA9_1_39275", "HTA9_1_39276", "HTA9_1_39277", "HTA9_1_39278", "HTA9_1_39279", "HTA9_1_39280", "HTA9_1_39281", "HTA9_1_39282", "HTA9_1_39283", "HTA9_1_39284", "HTA9_1_39285", "HTA9_1_39286", "HTA9_1_39287", "HTA9_1_39288", "HTA9_1_39289", "HTA9_1_39290", "HTA9_1_39291", "HTA9_1_39292", "HTA9_1_39293", "HTA9_1_39294", "HTA9_1_39295", "HTA9_1_39296", "HTA9_1_39297", "HTA9_1_39298", "HTA9_1_39299", "HTA9_1_39300", "HTA9_1_39301", "HTA9_1_39302", "HTA9_1_39303", "HTA9_1_39304", "HTA9_1_39305", "HTA9_1_39306", "HTA9_1_39307", "HTA9_1_39308", "HTA9_1_39309", "HTA9_1_39310", "HTA9_1_39311", "HTA9_1_39312", "HTA9_1_39313", "HTA9_1_39314", "HTA9_1_39315", "HTA9_1_39316", "HTA9_1_39317", "HTA9_1_39318", "HTA9_1_39319", "HTA9_1_39320", "HTA9_1_39321", "HTA9_1_39322", "HTA9_1_39323", "HTA9_1_39324", "HTA9_1_39325", "HTA9_1_39326", "HTA9_1_39327", "HTA9_1_39328", "HTA9_1_39329", "HTA9_1_39330", "HTA9_1_39331", "HTA9_1_39332", "HTA9_1_39333", "HTA9_1_39334", "HTA9_1_39335", "HTA9_1_39336", "HTA9_1_39337", "HTA9_1_39338", "HTA9_1_39339", "HTA9_1_39340", "HTA9_1_39341", "HTA9_1_39342", "HTA9_1_39343", "HTA9_1_39344", "HTA9_1_39345", "HTA9_1_39346", "HTA9_1_39347", "HTA9_1_39348", "HTA9_1_39349", "HTA9_1_39350", "HTA9_1_39351", "HTA9_1_39352", "HTA9_1_39353", "HTA9_1_39354", "HTA9_1_39355", "HTA9_1_39356", "HTA9_1_39357", "HTA9_1_39358", "HTA9_1_39359", "HTA9_1_39360", "HTA9_1_39361", "HTA9_1_39362", "HTA9_1_39363", "HTA9_1_39364", "HTA9_1_39365", "HTA9_1_39366", "HTA9_1_39367", "HTA9_1_39368", "HTA9_1_39369", "HTA9_1_39370", "HTA9_1_39371", "HTA9_1_39372", "HTA9_1_39373", "HTA9_1_39374", "HTA9_1_39375", "HTA9_1_39376", "HTA9_1_39377", "HTA9_1_39378", "HTA9_1_39379", "HTA9_1_39380", "HTA9_1_39381", "HTA9_1_39382", "HTA9_1_39383", "HTA9_1_39384", "HTA9_1_39385", "HTA9_1_39386", "HTA9_1_39387", "HTA9_1_39388", "HTA9_1_39389", "HTA9_1_39390", "HTA9_1_39391", "HTA9_1_39392", "HTA9_1_39393", "HTA9_1_39394", "HTA9_1_39395", "HTA9_1_39396", "HTA9_1_39397", "HTA9_1_39398", "HTA9_1_39399", "HTA9_1_39400", "HTA9_1_39401", "HTA9_1_39402", "HTA9_1_39403", "HTA9_1_39404", "HTA9_1_39405", 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"HTA9_1_40584", "HTA9_1_40585", "HTA9_1_40586", "HTA9_1_40587", "HTA9_1_40588", "HTA9_1_40589", "HTA9_1_40593", "HTA9_1_40595", "HTA9_1_40598", "HTA9_1_40599", "HTA9_1_40600", "HTA9_1_40601" ], "Eutils Date": "2022 Feb 15", "Eutils Title": "An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.", "Eutils Journal": "Cell reports. Medicine", "Eutils Sort Date": "2022/02/15 00:00", "Eutils Authors": "Johnson BE, Creason AL, Stommel JM, Keck JM, Parmar S, Betts CB, Blucher A, Boniface C, Bucher E, Burlingame E, Camp T, Chin K, Eng J, Estabrook J, Feiler HS, Heskett MB, Hu Z, Kolodzie A, Kong BL, Labrie M, Lee J, Leyshock P, Mitri S, Patterson J, Riesterer JL, Sivagnanam S, Somers J, Sudar D, Thibault G, Weeder BR, Zheng C, Nan X, Thompson RF, Heiser LM, Spellman PT, Thomas G, Demir E, Chang YH, Coussens LM, Guimaraes AR, Corless C, Goecks J, Bergan R, Mitri Z, Mills GB, Gray JW", "Eutils DOI": "10.1016/j.xcrm.2022.100525", "Cited In Number": 32, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=35243422" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233280", "HTAN Center ID": "HTA9", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41467-025-59788-x", "Title": "Imputing single-cell protein abundance in multiplex tissue imaging", "Authors": "Raphael Kirchgaessner, Cameron Watson, Allison Creason, Kaya Keutler, Jeremy Goecks", "Corresponding Author": "Jeremy Goecks", "Corresponding Author ORCID": "https://orcid.org/0000-0002-4583-5226", "Year of Publication": "2025", "Location of Publication": "Nature Communications", "Publication Abstract": "Multiplex tissue imaging enables single-cell spatial proteomics and transcriptomics but remains limited by incomplete molecular profiling, tissue loss, and probe failure. Here, we apply machine learning to impute single-cell protein abundance using multiplex tissue imaging data from a breast cancer cohort. We evaluate regularized linear regression, gradient-boosted trees, and deep learning autoencoders, incorporating spatial context to enhance imputation accuracy. Our models achieve mean absolute errors between 0.05-0.3 on a [0,1] scale, closely approximating ground truth values. Using imputed data, we classify single cells as pre- or post-treatment, demonstrating their biological relevance. These findings establish the feasibility of imputing missing protein abundance, highlight the advantages of spatial information, and support machine learning as a powerful tool for improving single-cell tissue imaging.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/40404617/", "Publication contains HTAN ID": "Yes", "Data Type": "mIHC", "Tool": "No", "Supporting Link": "https://github.com/goeckslab/MTIProteinImputation", "Supporting Link Description": "Source code of this work is freely available in the GitHub repository", "Publication-associated HTAN Parent Data File ID": [ "HTA9_3_1031", "HTA9_3_1041", "HTA9_15_1020", "HTA9_15_1015", "HTA9_14_1009", "HTA9_14_1006", "HTA9_15_1044", "HTA9_15_1047", "HTA9_15_1065", "HTA9_15_1048", "HTA9_15_1070", "HTA9_15_1037", "HTA9_14_1024", "HTA9_14_1040", "HTA9_14_1028", "HTA9_14_1019", "HTA9_14_1042", "HTA9_14_1038", "HTA9_3_1056", "HTA9_3_1043", "HTA9_3_1055", "HTA9_3_1046", "HTA9_3_1047", "HTA9_3_1062", "HTA9_3_1088", "HTA9_3_1085", "HTA9_3_1095", "HTA9_3_1087", "HTA9_3_1080", "HTA9_3_1098", "HTA9_15_1080", "HTA9_15_1090", "HTA9_15_1091", "HTA9_15_1097", "HTA9_15_1089", "HTA9_15_1084", "HTA9_14_1056", "HTA9_14_1068", "HTA9_14_1070", "HTA9_14_1072", "HTA9_14_1053", "HTA9_14_1057" ], "Eutils Date": "2025 May 22", "Eutils Title": "Imputing single-cell protein abundance in multiplex tissue imaging.", "Eutils Journal": "Nature communications", "Eutils Sort Date": "2025/05/22 00:00", "Eutils Authors": "Kirchgaessner R, Watson C, Creason A, Keutler K, Goecks J", "Eutils DOI": "10.1038/s41467-025-59788-x", "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233311", "HTAN Center ID": "HTA10", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41588-022-01088-x", "Title": "Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer", "Authors": "Winston R Becker, Stephanie A Nevins, Derek C Chen, Roxanne Chiu, Aaron M Horning, Tuhin K Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D Esplin, Anshul Kundaje, James M Ford, Christina Curtis, Michael P Snyder, William J Greenleaf", "Corresponding Author": "Michael P Snyder,William J Greenleaf", "Corresponding Author ORCID": "https://orcid.org/0000-0003-0784-7987,https://orcid.org/0000-0003-1409-3095", "Year of Publication": "2022", "Location of Publication": "Nature Genetics", "Publication Abstract": "To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,000 to 10,000 cells per sample for 48 polyps, 27 normal tissues and 6 CRCs collected from patients with or without germline APC mutations. A large fraction of polyp and CRC cells exhibit a stem-like phenotype, and we define a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progress from homeostasis to CRC. Advanced polyps contain increasing numbers of stem-like cells, regulatory T cells and a subtype of pre-cancer-associated fibroblasts. In the cancerous state, we observe T cell exhaustion, RUNX1-regulated cancer-associated fibroblasts and increasing accessibility associated with HNF4A motifs in epithelia. DNA methylation changes in sporadic CRC are strongly anti-correlated with accessibility changes along this continuum, further identifying regulatory markers for molecular staging of polyps.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/35726067/", "Publication contains HTAN ID": "Yes", "Data Type": "scATAC-seq,scRNA-seq,CODEX", "Tool": "Yes", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE201349,https://portal.hubmapconsortium.org/,https://github.com/winstonbecker/scCRC_continuum", "Supporting Link Description": "Sequencing data have been deposited in the Gene Expression Omnibus (GEO) with the accession code GSE201349^^^HuBMAP data portal (normal colon tissues under Stanford TMC)^^^Scripts for processing the single-cell data, generating the malignancy continuum and analyzing the WGS data", "Publication-associated HTAN Parent Data File ID": [ "HTA10_0000_16151281528062110084221322905769", "HTA10_0000_51277202575134703557245705760813", 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00:00", "Eutils Authors": "Becker WR, Nevins SA, Chen DC, Chiu R, Horning AM, Guha TK, Laquindanum R, Mills M, Chaib H, Ladabaum U, Longacre T, Shen J, Esplin ED, Kundaje A, Ford JM, Curtis C, Snyder MP, Greenleaf WJ", "Eutils DOI": "10.1038/s41588-022-01088-x", "Cited In Number": 179, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=35726067" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233311", "HTAN Center ID": "HTA10", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s43018-024-00831-z", "Title": "Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis", "Authors": "Edward D. Esplin, Casey Hanson, Si Wu, Aaron M. Horning, Nasim Barapour, Stephanie A. Nevins, Lihua Jiang, K\u00e9vin Contrepois, Hayan Lee, Tuhin K. Guha, Zheng Hu, Rozelle Laquindanum, Meredith A. Mills, Hassan Chaib, Roxanne Chiu, Ruiqi Jian, Joanne Chan, Mathew Ellenberger, Winston R. Becker, Bahareh Bahmani, Aziz Khan, Basil Michael, Annika K. Weimer, D. Glen Esplin, Jeanne Shen, Samuel Lancaster, Emma Monte, Thomas V. Karathanos, Uri Ladabaum, Teri A. Longacre, Anshul Kundaje, Christina Curtis, William J. Greenleaf, James M. Ford, Michael P. Snyder", "Corresponding Author": "Michael P Snyder", "Corresponding Author ORCID": "https://orcid.org/0000-0003-0784-7987", "Year of Publication": "2024", "Location of Publication": "Nature Cancer", "Publication Abstract": "Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study transitions of early precancer states to colorectal cancer (CRC). We performed deep multiomic profiling of 93 samples, including normal mucosa, benign polyps and dysplastic polyps, from six persons with FAP. Transcriptomic, proteomic, metabolomic and lipidomic analyses revealed a dynamic choreography of thousands of molecular and cellular events that occur during precancerous transitions toward cancer formation. These involve processes such as cell proliferation, immune response, metabolic alterations (including amino acids and lipids), hormones and extracellular matrix proteins. Interestingly, activation of the arachidonic acid pathway was found to occur early in hyperplasia; this pathway is targeted by aspirin and other nonsteroidal anti-inflammatory drugs, a preventative treatment under investigation in persons with FAP. Overall, our results reveal key genomic, cellular and molecular events during the earliest steps in CRC formation and potential mechanisms of pharmaceutical prophylaxis.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478120/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq,scATAC-seq", "Tool": "No", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE207954", "Supporting Link Description": "GSE207954", "Publication-associated HTAN Parent Data File ID": [ "HTA10_01_00402001", "HTA10_01_00402002", "HTA10_01_00502001", "HTA10_01_00502002", "HTA10_01_00702001", "HTA10_01_00702002", "HTA10_01_02102001", "HTA10_01_02102002", "HTA10_01_10202001", "HTA10_01_10202002", "HTA10_01_10702001", "HTA10_01_10702002", "HTA10_01_12202001", "HTA10_01_12202002", "HTA10_01_21002001", "HTA10_01_21002002", "HTA10_01_21402001", "HTA10_01_21402002", "HTA10_01_21902001", "HTA10_01_21902002", "HTA10_01_22202001", "HTA10_01_22202002", 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ED, Hanson C, Wu S, Horning AM, Barapour N, Nevins SA, Jiang L, Contrepois K, Lee H, Guha TK, Hu Z, Laquindanum R, Mills MA, Chaib H, Chiu R, Jian R, Chan J, Ellenberger M, Becker WR, Bahmani B, Khan A, Michael B, Weimer AK, Esplin DG, Shen J, Lancaster S, Monte E, Karathanos TV, Ladabaum U, Longacre TA, Kundaje A, Curtis C, Greenleaf WJ, Ford JM, Snyder MP", "Eutils DOI": "10.1038/s43018-024-00831-z", "Cited In Number": 12, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478120" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233254", "HTAN Center ID": "HTA10", "Publication Content Type": "Prepublication site for reviewers", "DOI": "", "Title": "Space-map: 3D single-cell atlas reconstruction from serial sections", "Authors": "Rongduo Han, Cihan Ruan, Bingqing Zhao, Yuqi Tan, Emma Monte, Bei Wei, Joanna Bi, Thomas V. Karathanos, Rozelle Laquindanum, Gregory W. Charville, Yiing Lin, Nam Ling, James M. Ford, Garry Nolan, Meng Wang, Chenchen Zhu and Michael Snyder", "Corresponding Author": "Michael Snyder", "Corresponding Author ORCID": "https://orcid.org/0000-0003-0784-7987", "Year of Publication": "2026", "Location of Publication": "", "Publication Abstract": "High-resolution three-dimensional (3D) tissue atlases promise to link cellular architecture to tissue function, but reconstructing them from serial sections containing millions of cells remains challenging. Here we present Space-map, an accurate and efficient method for reconstructing 3D tissue models from high-content spatial molecular profiles. Space-map combines multiscale feature matching with large-deformation diffeomorphic metric mapping to automate global alignment across serial sections while preserving local microanatomy. We generate spatial transcriptomics (Xenium; ~2.7 million cells) and proteomics (CODEX; ~4.8 million cells) datasets from serial sections to reconstruct 3D models of a colon polyp and healthy intestinal tissues. These models reveal cell-type heterogeneity in the polyp and preserve crypt and glandular architecture and mucosal-cavity continuity in healthy tissues. Benchmarking on these and public datasets demonstrates substantially higher registration accuracy and up to tenfold faster processing than existing methods, establishing Space-map as a robust and user-friendly framework for constructing 3D human tissue atlases at single-cell resolution.", "License": "", "PMID": "", "Publication contains HTAN ID": "", "Supporting Link": "https://github.com/czhu/space-map", "Supporting Link Description": "Space-map software", "Publication-associated HTAN Parent Data File ID": [ "HTA10_41_0080314001", "HTA10_41_0080414001", "HTA10_41_0080514001", "HTA10_41_0080614001", "HTA10_41_0080714001", "HTA10_41_0080814001", "HTA10_41_0080914001", "HTA10_41_0081014001", "HTA10_41_0081114001", "HTA10_41_0081214001", "HTA10_41_0081314001", "HTA10_41_0081414001", "HTA10_41_0081514001", "HTA10_41_0081614001", "HTA10_41_0081714001", "HTA10_41_0081814001", "HTA10_41_0081914001", "HTA10_41_0082014001", "HTA10_41_0082114001", "HTA10_41_0082214001", "HTA10_41_0082314001", "HTA10_41_0082414001", "HTA10_41_0082514001", "HTA10_41_0082614001", "HTA10_41_0082714001", "HTA10_41_0082814001", "HTA10_41_0082914001", "HTA10_41_0083014001", "HTA10_41_0083114001", "HTA10_41_0083214001", "HTA10_41_0080311001", "HTA10_41_0080411001", "HTA10_41_0080511001", "HTA10_41_0080611001", "HTA10_41_0080711001", "HTA10_41_0080811001", "HTA10_41_0080911001", "HTA10_41_0081011001", "HTA10_41_0081111001", "HTA10_41_0081211001", "HTA10_41_0081311001", "HTA10_41_0081411001", "HTA10_41_0081511001", "HTA10_41_0081611001", "HTA10_41_0081711001", "HTA10_41_0081811001", "HTA10_41_0081911001", "HTA10_41_0082011001", "HTA10_41_0082111001", "HTA10_41_0082211001", "HTA10_41_0082311001", "HTA10_41_0082411001", "HTA10_41_0082511001", "HTA10_41_0082611001", "HTA10_41_0082711001", "HTA10_41_0082811001", "HTA10_41_0082911001", "HTA10_41_0083011001", "HTA10_41_0083111001", "HTA10_41_0083211001" ], "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233311", "HTAN Center ID": "HTA10", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s43018-024-00823-z", "Title": "Global loss of promoter\u2013enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis", "Authors": "Yizhou Zhu, Hayan Lee, Shannon White, Annika K. Weimer, Emma Monte, Aaron Horning, Stephanie A. Nevins, Edward D. Esplin, Kristina Paul, Gat Krieger, Zohar Shipony, Roxanne Chiu, Rozelle Laquindanum, Thomas V. Karathanos, Melissa W. Y. Chua, Meredith Mills, Uri Ladabaum, Teri Longacre, Jeanne Shen, Ariel Jaimovich, Doron Lipson, Anshul Kundaje, William J. Greenleaf, Christina Curtis, James M. Ford, Michael P. Snyder", "Corresponding Author": "Michael P Snyder", "Corresponding Author ORCID": "https://orcid.org/0000-0003-0784-7987", "Year of Publication": "2024", "Location of Publication": "Nature Cancer", "Publication Abstract": "Although three-dimensional (3D) genome architecture is crucial for gene regulation, its role in disease remains elusive. We traced the evolution and malignant transformation of colorectal cancer (CRC) by generating high-resolution chromatin conformation maps of 33 colon samples spanning different stages of early neoplastic growth in persons with familial adenomatous polyposis (FAP). Our analysis revealed a substantial progressive loss of genome-wide cis-regulatory connectivity at early malignancy stages, correlating with nonlinear gene regulation effects. Genes with high promoter\u2013enhancer (P\u2013E) connectivity in unaffected mucosa were not linked to elevated baseline expression but tended to be upregulated in advanced stages. Inhibiting highly connected promoters preferentially represses gene expression in CRC cells compared to normal colonic epithelial cells. Our results suggest a two-phase model whereby neoplastic transformation reduces P\u2013E connectivity from a redundant state to a rate-limiting one for transcriptional levels, highlighting the intricate interplay between 3D genome architecture and gene regulation during early CRC progression.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478119/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq,scATAC-seq", "Tool": "No", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE207954", "Supporting Link Description": "GSE207954", "Publication-associated HTAN Parent Data File ID": [ "HTA10_01_00702011", "HTA10_01_00702012", "HTA10_01_007020201", "HTA10_01_01102001", "HTA10_01_01102002", "HTA10_01_011020201", "HTA10_01_01302001", "HTA10_01_01302002", "HTA10_01_013020201", "HTA10_01_01902001", "HTA10_01_01902002", "HTA10_01_019020201", "HTA10_02_00102001", "HTA10_02_00102002", "HTA10_02_001020201", "HTA10_02_00202001", 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"HTA10_03_05204001", "HTA10_03_05205001", "HTA10_03_05205002", "HTA10_03_05205003", "HTA10_03_05205004", "HTA10_04_00204002", "HTA10_04_00204001", "HTA10_04_00205001", "HTA10_04_00205002", "HTA10_04_00205003", "HTA10_04_00205004", "HTA10_04_00804002", "HTA10_04_00804001", "HTA10_04_00805001", "HTA10_04_00805002", "HTA10_04_00805003", "HTA10_04_00805004", "HTA10_04_01004002", "HTA10_04_01004001", "HTA10_04_01005001", "HTA10_04_01005002", "HTA10_04_01005003", "HTA10_04_01005004", "HTA10_0000_16151281528062110084221322905769", "HTA10_0000_51277202575134703557245705760813" ], "Eutils Date": "2024 Nov", "Eutils Title": "Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis.", "Eutils Journal": "Nature cancer", "Eutils Sort Date": "2024/11/01 00:00", "Eutils Authors": "Zhu Y, Lee H, White S, Weimer AK, Monte E, Horning A, Nevins SA, Esplin ED, Paul K, Krieger G, Shipony Z, Chiu R, Laquindanum R, Karathanos TV, Chua MWY, Mills M, Ladabaum U, Longacre T, Shen J, Jaimovich A, Lipson D, Kundaje A, Greenleaf WJ, Curtis C, Ford JM, Snyder MP", "Eutils DOI": "10.1038/s43018-024-00823-z", "Cited In Number": 15, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478119" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233291", "HTAN Center ID": "HTA11", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.cell.2021.11.031", "Title": "Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps", "Authors": "Bob Chen, Cherie' R Scurrah, Eliot T McKinley, Alan J Simmons, Marisol A Ramirez-Solano, Xiangzhu Zhu, Nicholas O Markham, Cody N Heiser, Paige N Vega, Andrea Rolong, Hyeyon Kim, Quanhu Sheng, Julia L Drewes, Yuan Zhou, Austin N Southard-Smith, Yanwen Xu, James Ro, Angela L Jones, Frank Revetta, Lynne D Berry, Hiroaki Niitsu, Mirazul Islam, Karin Pelka, Matan Hofree, Jonathan H Chen, Siranush Sarkizova, Kimmie Ng, Marios Giannakis, Genevieve M Boland, Andrew J Aguirre, Ana C Anderson, Orit Rozenblatt-Rosen, Aviv Regev, Nir Hacohen, Kenta Kawasaki, Toshiro Sato, Jeremy A Goettel, William M Grady, Wei Zheng, M Kay Washington, Qiuyin Cai, Cynthia L Sears, James R Goldenring, Jeffrey L Franklin, Timothy Su, Won Jae Huh, Simon Vandekar, Joseph T Roland, Qi Liu, Robert J Coffey, Martha J Shrubsole, Ken S Lau", "Corresponding Author": "Robert J Coffey,Martha J Shrubsole,Ken S Lau", "Corresponding Author ORCID": "https://orcid.org/0000-0003-3769-5267,https://orcid.org/0000-0002-5591-7575,https://orcid.org/0000-0001-8438-0319", "Year of Publication": "2021", "Location of Publication": "Cell", "Publication Abstract": "Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting CRC counterparts. Integrative analysis of 128 datasets from 62 participants reveals adenomas arise from WNT-driven expansion of stem cells, while serrated polyps derive from differentiated cells through gastric metaplasia. Metaplasia-associated damage is coupled to a cytotoxic immune microenvironment preceding hypermutation, driven partly by antigen-presentation differences associated with tumor cell-differentiation status. Microsatellite unstable CRCs contain distinct non-metaplastic regions where tumor cells acquire stem cell properties and cytotoxic immune cells are depleted. Our multi-omic atlas provides insights into malignant progression of colorectal polyps and their microenvironment, serving as a framework for precision surveillance and prevention of CRC.", "License": "", "PMID": "https://pubmed.ncbi.nlm.nih.gov/34910928/", "Publication contains HTAN ID": "Yes", "Data Type": "scRNA-seq", "Tool": "No", "Supporting Link": "https://github.com/Ken-Lau-Lab/STAR_Protocol,https://github.com/Ken-Lau-Lab/STAR_Methods", "Supporting Link Description": "All original code used to process scRNA-seq data^^^Code repository containing the analysis of post-processed sequencing data, as performed in this study", "Publication-associated HTAN Parent Data File ID": [ "HTA11_1938_200000101135111", "HTA11_6134_200000101135111", "HTA11_1938_200000101131111", "HTA11_1938_200000101131121", "HTA11_6134_200000101131111", "HTA11_6134_200000101131121", "HTA11_1938_200000101132111", "HTA11_1938_200000101132111", "HTA11_6134_200000101132111", "HTA11_6134_200000101132111", 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"https://cells.ucsc.edu/?ds=htan-vumc+chen", "Eutils Date": "2021 Dec 22", "Eutils Title": "Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.", "Eutils Journal": "Cell", "Eutils Sort Date": "2021/12/22 00:00", "Eutils Authors": "Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS", "Eutils DOI": "10.1016/j.cell.2021.11.031", "Cited In Number": 203, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=34910928" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233291", "HTAN Center ID": "HTA11", "Publication Content Type": "Prepublication site for reviewers", "DOI": "", "Title": "Regulatory macrophages contribute to tumor cell plasticity in colorectal cancer metastases", "Authors": "Cottam MA, Mirza MB, Arner EN, Siddiqui MT, Marincola Smith P, Lipscombe C, Revette F, Hatem Z, Tasneem N, Cameron A, Beckermann KE, Edwards J, Rathmell JC, Lau KS, Washington K, Jamieson NB, Raoof M, Idrees K", "Corresponding Author": "Kamran Idrees", "Corresponding Author ORCID": "https://orcid.org/0000-0003-0911-4461", "Year of Publication": "2025", "Location of Publication": "Nature Communications", "Publication Abstract": "Metastatic disease is the most common cause of death in colorectal cancer. To better understand the cellular landscape of colorectal metastasis, we profiled primary tumors and liver, lung, and peritoneal metastases using single-cell RNA sequencing. Our analysis revealed tumor epithelial cells expressing markers of transcriptional plasticity. Tumor cells with plasticity markers were spatially enriched at the tumor-stroma interface. Treatment of tumor cells with patient derived cell-free malignant ascites impaired expression of proliferation and stem-like markers in favor of plasticity markers and enhanced migration. Profiling of tumor-associated macrophages from colorectal metastases identified enrichment for a lipid-handling features and high spatial correlation with plastic tumor cells. Furthermore, co-culture of colorectal tumor cells with CD11b+ macrophages isolated from colorectal malignant ascites was sufficient to recapitulate tumor cell plasticity in vitro. Taken together, our results suggest that tumor-associated macrophages contribute to disease progression through development of pro-metastatic features including cellular migration and transcriptional plasticity.", "License": "", "PMID": "", "Publication contains HTAN ID": "", "Data Type": "", "Tool": "", "Supporting Link": "", "Supporting Link Description": "", "Publication-associated HTAN Parent Data File ID": [ "HTA11_20254139_101", "HTA11_20254139_102", "HTA11_20254139_301", "HTA11_20254139_302", "HTA11_202560911_101", "HTA11_202560911_102", "HTA11_20256091_201", "HTA11_20256091_202", "HTA11_20256091_401", "HTA11_20256091_402", "HTA11_202560915_501", "HTA11_202560915_502", "HTA11_2025431401_101", "HTA11_2025431401_102", "HTA11_20254954_101", "HTA11_20254954_102", "HTA11_20254720_101", "HTA11_20254720_102", "HTA11_20254720_201", "HTA11_20254720_202", "HTA11_20255091_101", "HTA11_20255091_102", "HTA11_20255179_101", "HTA11_20255179_102", "HTA11_20255179_201", "HTA11_20255179_202", "HTA11_20255385_101", "HTA11_20255385_102", "HTA11_20255385_301", "HTA11_20255385_302", "HTA11_20255474_101", "HTA11_20255474_102", "HTA11_20255474_201", "HTA11_20255474_202", "HTA11_202560116_1001", "HTA11_202560116_1002", "HTA11_202560116_1101", "HTA11_202560116_1102", "HTA11_202560116_1201", "HTA11_202560116_1202", "HTA11_202560116_601", "HTA11_202560116_602", "HTA11_202560116_901", "HTA11_202560116_902", "HTA11_202560116_301", "HTA11_202560116_302", "HTA11_202560119_101", "HTA11_202560119_102", "HTA11_202560119_201", "HTA11_202560119_202", "HTA11_20254139_103", "HTA11_20254139_303", "HTA11_202560911_103", "HTA11_202560912_203", "HTA11_202560912_403", "HTA11_202560915_503", "HTA11_2025431401_105", "HTA11_20254954_103", "HTA11_20254720_103", "HTA11_20254720_203", "HTA11_20255091_103", "HTA11_20255179_103", "HTA11_20255179_203", "HTA11_20255385_103", "HTA11_20255385_303", "HTA11_20255475_103", "HTA11_20255474_203", "HTA11_202560116_1003", "HTA11_202560116_1103", "HTA11_202560116_1203", "HTA11_202560116_603", "HTA11_202560116_903", "HTA11_202560116_303", "HTA11_202560119_103", "HTA11_202560119_203", "HTA11_20250000_1", "HTA11_20251_201", "HTA11_20251_202", "HTA11_20251_203", "HTA11_20251_204", "HTA11_20252_201", "HTA11_20252_202", "HTA11_20252_203", "HTA11_20252_204", "HTA11_20251_205", "HTA11_20252_205", "HTA11_20251_206", "HTA11_20252_206", "HTA11_20251_207", "HTA11_20252_207", "HTA11_20251_208", "HTA11_20252_208", "HTA11_20251_209", "HTA11_20252_209", "HTA11_20251_210", "HTA11_20252_210", "HTA11_20251_211", "HTA11_20252_211", "HTA11_20251_212", "HTA11_20252_212" ], "Cited In Number": 0 }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233291", "HTAN Center ID": "HTA11", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1016/j.cell.2023.11.006", "Title": "Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors", "Authors": "Cody N Heiser, Alan J Simmons, Frank Revetta, Eliot T McKinley, Marisol A Ramirez-Solano, Jiawei Wang, Harsimran Kaur, Justin Shao, Gregory D Ayers, Yu Wang, Sarah E Glass, Naila Tasneem, Zhengyi Chen, Yan Qin, William Kim, Andrea Rolong, Bob Chen, Paige N Vega, Julia L Drewes, Nicholas O Markham, Nabil Saleh, Fotis Nikolos, Simon Vandekar, Angela L Jones, M Kay Washington, Joseph T Roland, Keith S Chan, Thomas Sch\u00fcrpf, Cynthia L Sears, Qi Liu, Martha J Shrubsole, Robert J Coffey, Ken S Lau", "Corresponding Author": "Robert J Coffey, Ken S Lau", "Corresponding Author ORCID": "https://orcid.org/0000-0003-3769-5267,https://orcid.org/0000-0001-8438-0319", "Year of Publication": "2023", "Location of Publication": "Cell", "Publication Abstract": "Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 human colorectal specimens enabled phylogeographic mapping of tumor evolution that revealed individualized progression trajectories and accompanying microenvironmental and clonal alterations. Phylogeographic mapping ordered genetic events, classified tumors by their evolutionary dynamics, and placed clonal regions along global pseudotemporal progression trajectories encompassing the chromosomal instability (CIN+) and hypermutated (HM) pathways. Integrated single-cell and spatial transcriptomic data revealed recurring epithelial programs and infiltrating immune states along progression pseudotime. We discovered an immune exclusion signature (IEX), consisting of extracellular matrix regulators DDR1, TGFBI, PAK4, and DPEP1, that charts with CIN+ tumor progression, is associated with reduced cytotoxic cell infiltration, and shows prognostic value in independent cohorts. This spatial multi-omic atlas provides insights into colorectal tumor-microenvironment co-evolution, serving as a resource for stratification and targeted treatments.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/38065082/", "Publication contains HTAN ID": "Yes", "Data Type": "10X Visium,Bulk DNA,H&E,MxIF,scRNA-seq", "Tool": "No", "Supporting Link": "https://github.com/Ken-Lau-Lab/spatial_CRC_atlas,https://github.com/Ken-Lau-Lab/spatial_CRC_atlas_imaging,https://osf.io/hftq2/", "Supporting Link Description": "Code used to perform analyses on WES, scRNA, and ST data^^^Code used to perform analyses on MxIF and spatial registration^^^Annotated, pre-processed data compatible with the codebase", "Publication-associated HTAN Parent Data File ID": [ "HTA11_1938_20000010115220010010000130006", "HTA11_1938_20000010115220010010000120005", "HTA11_1938_20000010115220010010000140007", "HTA11_1938_20000010115220010010000320008", "HTA11_1938_20000010115220010010000340009", 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"PublicationManifest", "HTAN Grant ID": "CA233291", "HTAN Center ID": "HTA11", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41586-024-07954-4", "Title": "Temporal recording of mammalian development and precancer", "Authors": "Mirazul Islam, Yilin Yang, Alan J Simmons, Vishal M Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh T Trinh, Paola Molina, Marisol A Ramirez-Solano, Iannish Sadien, Jinzhuang Dou, Ken Chen, Mark A Magnuson, Jeffrey C Rathmell, Ian G Macara, Douglas Winton, Qi Liu, Hamim Zafar, Reza Kalhor, George M Church, Martha J Shrubsole, Robert J Coffey, Ken S Lau", "Corresponding Author": "Robert J Coffey,Ken S Lau", "Corresponding Author ORCID": "https://orcid.org/0000-0003-3769-5267,https://orcid.org/0000-0001-8438-0319", "Year of Publication": "2024", "Location of Publication": "Nature", "Publication Abstract": "Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations, an alternative solution leverages irreversible genetic changes, such as naturally occurring mutations, to create indelible marks that enables retrospective temporal ordering. Using a multipurpose, single-cell CRISPR platform, we developed a molecular clock approach to record the timing of cellular events and clonality in vivo, with incorporation of cell state and lineage information. Using this approach, we uncovered precise timing of tissue-specific cell expansion during mouse embryonic development, unconventional developmental relationships between cell types and new epithelial progenitor states by their unique genetic histories. Analysis of mouse adenomas, coupled to multiomic and single-cell profiling of human precancers, with clonal analysis of 418\u2009human polyps, demonstrated the occurrence of polyclonal initiation in 15\u201330% of colonic precancers, showing their origins from multiple normal founders. Our study presents a multimodal framework that lays the foundation for in vivo recording, integrating synthetic or natural indelible genetic changes with single-cell analyses, to explore the origins and timing of development and tumorigenesis in mammalian systems.", "License": "CC-BY-NC-ND-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478207/", "Publication contains HTAN ID": "No", "Data Type": "10X Visium,Bulk DNA,H&E,MxIF,scRNA-seq", "Tool": "No", "Supporting Link": "https://github.com/Ken-Lau-Lab/NSC-seq", "Supporting Link Description": "NSC-seq data analysis pipeline", "Publication-associated HTAN Parent Data File ID": [ "HTA11_78_200000101121111", "HTA11_78_200000101121121", "HTA11_78_200000101122111", "HTA11_78_200000101123111", "HTA11_78_200000101113111", "HTA11_78_200000101113211", "HTA11_0_14001", "HTA11_0_14002", "HTA11_0_14003", "HTA11_0_14005", "HTA11_0_14006", "HTA11_0_14009", "HTA11_78_200000990121111", "HTA11_78_200000990121121", "HTA11_78_200000990122111", 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00:00", "Eutils Authors": "Islam M, Yang Y, Simmons AJ, Shah VM, Musale KP, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien ID, Dou J, Rolong A, Chen K, Magnuson MA, Rathmell JC, Macara IG, Winton DJ, Liu Q, Zafar H, Kalhor R, Church GM, Shrubsole MJ, Coffey RJ, Lau KS", "Eutils DOI": "10.1038/s41586-024-07954-4", "Cited In Number": 22, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478207" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233303", "HTAN Center ID": "HTA12", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s43018-024-00773-6", "Title": "Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages", "Authors": "Michael D. Iglesia, Reyka G. Jayasinghe, Siqi Chen, Nadezhda V. Terekhanova, John M. Herndon, Erik Storrs, Alla Karpova, Daniel Cui Zhou, Nataly Naser Al Deen, Andrew T. Shinkle, Rita Jui-Hsien Lu, Wagma Caravan, Andrew Houston, Yanyan Zhao, Kazuhito Sato, Preet Lal, Cherease Street, Fernanda Martins Rodrigues, Austin N. Southard-Smith, Andr\u00e9 Luiz N. Targino da Costa, Houxiang Zhu, Chia-Kuei Mo, Lisa Crowson, Robert S. Fulton, Matthew A. Wyczalkowski, Catrina C. Fronick, Lucinda A. Fulton, Hua Sun, Sherri R. Davies, Elizabeth L. Appelbaum, Sara E. Chasnoff, Madelyn Carmody, Candace Brooks, Ruiyang Liu, Michael C. Wendl, Clara Oh, Diane Bender, Carlos Cruchaga, Oscar Harari, Andrea Bredemeyer, Kory Lavine, Ron Bose, Julie Margenthaler, Jason M. Held, Samuel Achilefu, Foluso Ademuyiwa, Rebecca Aft, Cynthia Ma, Graham A. Colditz, Tao Ju, Stephen T. Oh, James Fitzpatrick, E. Shelley Hwang, Kooresh I. Shoghi, Milan G. Chheda, Deborah J. Veis, Feng Chen, Ryan C. Fields, William E. Gillanders, Li Ding", "Corresponding Author": "William E. Gillanders, Li Ding", "Corresponding Author ORCID": "https://orcid.org/0000-0002-0465-3071,https://orcid.org/0000-0001-6176-8943,https://orcid.org/0000-0003-1517-2975", "Year of Publication": "2024", "Location of Publication": "Nature Cancer", "Publication Abstract": "Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and single-nucleus multi-omic techniques as well as spatial transcriptomics and multiplex imaging on 61 samples from 37 patients with BC to show characteristic links in gene expression and chromatin accessibility between BC subtypes and their putative cells of origin. Regulatory network analysis of transcription factors underscored the importance of BHLHE40 in luminal BC and luminal mature cells and KLF5 in basal-like tumors and luminal progenitor cells. Furthermore, we identify key genes defining the basal-like (SOX6 and KCNQ3) and luminal A/B (FAM155A and LRP1B) lineages. Exhausted CTLA4-expressing CD8+\u2009T cells were enriched in basal-like BC, suggesting an altered means of immune dysfunction. These findings demonstrate analysis of paired transcription and chromatin accessibility at the single-cell level is a powerful tool for investigating cancer lineage and highlight transcriptional networks that define basal and luminal BC lineages.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478117/", "Publication contains HTAN ID": "Yes", "Data Type": "10X Visium,Bulk RNA-seq,CODEX,scRNA-seq,scATAC-seq", "Tool": "Yes", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240577,https://github.com/ding-lab/HTAN_BRCA_publication/tree/main", "Supporting Link Description": "All mouse snRNA/snATAC data have been deposited to the Gene Expression Omnibus under series GSE240577.^^^Scripts related to specific analysis in the paper can be found on GitHub.", "Publication-associated HTAN Parent Data File ID": [ "HTA12_235_1000", "HTA12_235_1001", "HTA12_235_1002", "HTA12_235_1003", "HTA12_235_1004", "HTA12_235_1005", "HTA12_235_1006", "HTA12_235_1007", 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"HTA12_249_1002", "HTA12_249_1003", "HTA12_250_1000", "HTA12_250_1001", "HTA12_251_1000", "HTA12_251_1001", "HTA12_251_1002", "HTA12_251_1003", "HTA12_252_1000", "HTA12_252_1001", "HTA12_252_1002", "HTA12_252_1003", "HTA12_149_1000", "HTA12_149_1001", "HTA12_233_2000", "HTA12_234_2000", "HTA12_234_2001", "HTA12_236_2002", "HTA12_243_2003", "HTA12_243_2004", "HTA12_123_2000", "HTA12_246_2000", "HTA12_248_2000", "HTA12_249_2000", "HTA12_250_2000", "HTA12_251_2000", "HTA12_252_2000", "HTA12_149_2000", "HTA12_233_3000", "HTA12_233_3001", "HTA12_233_3002", "HTA12_234_3000", "HTA12_234_3001", "HTA12_234_3002", "HTA12_234_3003", "HTA12_234_3004", "HTA12_234_3005", "HTA12_235_3000", "HTA12_235_3001", "HTA12_235_3002", "HTA12_235_3003", "HTA12_235_3004", "HTA12_235_3005", "HTA12_235_3006", "HTA12_235_3007", "HTA12_235_3008", "HTA12_236_3000", "HTA12_236_3001", "HTA12_236_3002", "HTA12_236_3003", "HTA12_236_3004", "HTA12_236_3005", "HTA12_236_3006", "HTA12_236_3007", "HTA12_236_3008", "HTA12_237_3000", "HTA12_237_3001", "HTA12_237_3002", "HTA12_237_3003", "HTA12_237_3004", "HTA12_237_3005", "HTA12_238_3000", "HTA12_238_3001", "HTA12_238_3002", "HTA12_238_3003", "HTA12_238_3004", "HTA12_238_3005", "HTA12_239_3000", "HTA12_239_3001", "HTA12_239_3002", "HTA12_239_3003", "HTA12_239_3004", "HTA12_239_3005", "HTA12_239_3006", "HTA12_239_3007", "HTA12_239_3008", "HTA12_240_3000", "HTA12_240_3001", "HTA12_240_3002", "HTA12_120_3003", "HTA12_120_3004", "HTA12_120_3005", "HTA12_120_3006", "HTA12_120_3007", "HTA12_120_3008", "HTA12_241_3000", "HTA12_241_3001", "HTA12_241_3002", "HTA12_241_3003", "HTA12_241_3004", "HTA12_241_3005", "HTA12_242_3000", "HTA12_242_3001", "HTA12_242_3002", "HTA12_242_3003", "HTA12_242_3004", "HTA12_242_3005", "HTA12_242_3006", "HTA12_242_3007", "HTA12_242_3008", "HTA12_243_3000", "HTA12_243_3001", "HTA12_243_3002", "HTA12_243_3003", "HTA12_243_3004", "HTA12_243_3005", "HTA12_243_3006", "HTA12_243_3007", "HTA12_243_3008", "HTA12_243_3009", "HTA12_243_3010", "HTA12_243_3011", "HTA12_123_3003", "HTA12_123_3004", "HTA12_123_3005", "HTA12_244_3000", "HTA12_244_3001", "HTA12_244_3002", "HTA12_244_3003", "HTA12_244_3004", "HTA12_244_3005", "HTA12_244_3006", "HTA12_244_3007", "HTA12_244_3008", "HTA12_127_3003", "HTA12_127_3004", "HTA12_127_3005", "HTA12_127_3006", "HTA12_127_3007", "HTA12_127_3008", "HTA12_245_3000", "HTA12_245_3001", "HTA12_245_3002", "HTA12_245_3003", "HTA12_245_3004", "HTA12_245_3005", "HTA12_246_3000", "HTA12_246_3001", "HTA12_246_3002", "HTA12_247_3000", "HTA12_247_3001", "HTA12_247_3002", "HTA12_243_3012", "HTA12_243_3013", "HTA12_243_3014", "HTA12_243_3015", "HTA12_248_3000", "HTA12_248_3001", "HTA12_248_3002", "HTA12_248_3003", "HTA12_249_3000", "HTA12_249_3001", "HTA12_249_3002", "HTA12_249_3003", "HTA12_250_3000", "HTA12_250_3001", "HTA12_250_3002", "HTA12_250_3003", "HTA12_251_3000", "HTA12_251_3001", "HTA12_251_3002", "HTA12_251_3003", "HTA12_252_3000", "HTA12_252_3001", "HTA12_252_3002", "HTA12_252_3003", "HTA12_149_3000", "HTA12_149_3001", "HTA12_149_3002", "HTA12_149_3003", "HTA12_235_4000", "HTA12_235_4001", "HTA12_235_4002", "HTA12_236_4000", "HTA12_236_4001", "HTA12_237_4000", "HTA12_237_4001", "HTA12_238_4000", "HTA12_238_4001", "HTA12_239_4000", "HTA12_239_4001", "HTA12_239_4002", "HTA12_240_4000", "HTA12_120_4000", "HTA12_120_4001", "HTA12_241_4000", "HTA12_241_4001", "HTA12_242_4000", "HTA12_242_4001", "HTA12_242_4002", "HTA12_243_4000", "HTA12_243_4001", "HTA12_243_4002", "HTA12_244_4000", "HTA12_244_4001", "HTA12_244_4002", "HTA12_127_4000", "HTA12_127_4001", "HTA12_245_4000", "HTA12_245_4001", "HTA12_247_4000", "HTA12_118_4000", "HTA12_119_4000", "HTA12_120_4002", "HTA12_243_4003", "HTA12_243_4004", "HTA12_123_4000", "HTA12_124_4000", "HTA12_126_4000", "HTA12_127_4002", "HTA12_129_4000", "HTA12_130_4000", "HTA12_131_4000", "HTA12_134_4000", "HTA12_135_4000", "HTA12_139_4000", "HTA12_142_4000", "HTA12_144_4000", "HTA12_145_4000", "HTA12_248_4000", "HTA12_249_4000", "HTA12_250_4000", "HTA12_251_4000", "HTA12_252_4000", "HTA12_149_4000", "HTA12_233_4000", "HTA12_234_4000", "HTA12_234_4001", "HTA12_236_4002", "HTA12_123_4001", "HTA12_246_4000", "HTA12_233_1002", "HTA12_233_1003", "HTA12_234_1004", "HTA12_234_1005", "HTA12_237_1016", "HTA12_237_1017", "HTA12_238_1016", "HTA12_238_1017", "HTA12_239_1012", "HTA12_239_1013", "HTA12_240_1002", "HTA12_240_1003", "HTA12_240_1004", "HTA12_240_1005", "HTA12_241_1004", "HTA12_241_1005", "HTA12_242_1006", "HTA12_242_1007", "HTA12_242_1008", "HTA12_242_1009", "HTA12_243_1010", "HTA12_243_1011", "HTA12_244_1006", "HTA12_244_1007", "HTA12_244_1008", "HTA12_244_1009", "HTA12_245_1004", "HTA12_245_1005", "HTA12_246_1002", "HTA12_246_1003", "HTA12_248_1002", "HTA12_248_1003", "HTA12_249_1004", "HTA12_249_1005", "HTA12_250_1002", "HTA12_250_1003", "HTA12_251_1004", "HTA12_251_1005", "HTA12_252_1004", "HTA12_252_1005", "HTA12_233_1004", "HTA12_233_1005", "HTA12_235_1024", "HTA12_235_1025", "HTA12_235_1026", "HTA12_235_1027", "HTA12_236_1018", "HTA12_236_1019", "HTA12_236_1020", "HTA12_236_1021", "HTA12_237_1018", "HTA12_237_1019", "HTA12_237_1020", "HTA12_237_1021", "HTA12_238_1018", "HTA12_238_1019", "HTA12_239_1014", "HTA12_239_1015", "HTA12_239_1016", "HTA12_239_1017", "HTA12_239_1018", "HTA12_239_1019", "HTA12_240_1006", "HTA12_240_1007", "HTA12_120_1004", "HTA12_120_1005", "HTA12_241_1006", "HTA12_241_1007", "HTA12_241_1008", "HTA12_241_1009", "HTA12_242_1010", "HTA12_242_1011", "HTA12_242_1012", "HTA12_242_1013", "HTA12_243_1012", "HTA12_243_1013", "HTA12_243_1014", "HTA12_243_1015", "HTA12_123_1002", "HTA12_123_1003", "HTA12_244_1010", "HTA12_244_1011", "HTA12_244_1012", "HTA12_244_1013", "HTA12_244_1014", "HTA12_244_1015", "HTA12_127_1004", "HTA12_127_1005", "HTA12_245_1006", "HTA12_245_1007", "HTA12_245_1008", "HTA12_245_1009", "HTA12_135_1000", "HTA12_135_1001", "HTA12_246_1004", "HTA12_246_1005", "HTA12_248_1004", "HTA12_248_1005", "HTA12_248_1006", "HTA12_248_1007", "HTA12_248_1008", "HTA12_248_1009", "HTA12_249_1006", "HTA12_249_1007", "HTA12_250_1004", "HTA12_250_1005", "HTA12_251_1006", "HTA12_251_1007", "HTA12_252_1006", "HTA12_252_1007", "HTA12_233_1006", "HTA12_233_1007", "HTA12_118_1000", "HTA12_118_1001", "HTA12_119_1000", "HTA12_119_1001", "HTA12_234_1006", "HTA12_234_1007", "HTA12_235_1028", "HTA12_235_1029", "HTA12_235_1030", "HTA12_235_1031", "HTA12_235_1032", "HTA12_235_1033", "HTA12_236_1022", "HTA12_236_1023", "HTA12_236_1024", "HTA12_236_1025", "HTA12_236_1026", "HTA12_236_1027", "HTA12_236_1028", "HTA12_236_1029", "HTA12_237_1022", "HTA12_237_1023", "HTA12_237_1024", "HTA12_237_1025", "HTA12_238_1020", "HTA12_238_1021", "HTA12_239_1020", "HTA12_239_1021", "HTA12_239_1022", "HTA12_239_1023", "HTA12_239_1024", "HTA12_239_1025", "HTA12_239_1026", "HTA12_239_1027", "HTA12_240_1008", "HTA12_240_1009", "HTA12_120_1006", "HTA12_120_1007", "HTA12_120_1008", "HTA12_120_1009", "HTA12_120_1014", "HTA12_120_1015", "HTA12_241_1010", "HTA12_241_1011", "HTA12_241_1012", "HTA12_241_1013", "HTA12_242_1014", "HTA12_242_1015", "HTA12_243_1016", "HTA12_243_1017", "HTA12_243_1018", "HTA12_243_1019", "HTA12_123_1004", "HTA12_123_1005", "HTA12_123_1006", "HTA12_123_1007", "HTA12_124_1000", "HTA12_124_1001", "HTA12_244_1016", "HTA12_244_1017", "HTA12_244_1018", "HTA12_244_1019", "HTA12_244_1020", "HTA12_244_1021", "HTA12_127_1006", "HTA12_127_1007", "HTA12_127_1008", "HTA12_127_1009", "HTA12_245_1010", "HTA12_245_1011", "HTA12_245_1012", "HTA12_245_1013", "HTA12_129_1000", "HTA12_129_1001", "HTA12_130_1000", "HTA12_130_1001", "HTA12_131_1000", "HTA12_131_1001", "HTA12_134_1000", "HTA12_134_1001", "HTA12_135_1002", "HTA12_135_1003", "HTA12_246_1006", "HTA12_246_1007", "HTA12_139_1000", "HTA12_139_1001", "HTA12_142_1000", "HTA12_142_1001", "HTA12_145_1000", "HTA12_145_1001", "HTA12_248_1010", "HTA12_248_1011", "HTA12_248_1012", "HTA12_248_1013", "HTA12_248_1014", "HTA12_248_1015", "HTA12_249_1008", "HTA12_249_1009", "HTA12_250_1006", "HTA12_250_1007", "HTA12_251_1008", "HTA12_251_1009", "HTA12_252_1008", "HTA12_252_1009", "HTA12_129_1002", "HTA12_129_1003", "HTA12_129_1004", "HTA12_129_1005", "HTA12_129_1006", "HTA12_129_1007", "HTA12_134_1002", "HTA12_134_1003", "HTA12_134_1004", "HTA12_134_1005", "HTA12_134_1006", "HTA12_134_1007", "HTA12_134_1008", "HTA12_134_1009", "HTA12_135_1004", "HTA12_135_1005", "HTA12_135_1006", "HTA12_135_1007", "HTA12_135_1008", "HTA12_135_1009", "HTA12_135_1014", "HTA12_135_1015", "HTA12_135_1016", "HTA12_135_1017", "HTA12_135_1018", "HTA12_135_1019", "HTA12_246_1008", "HTA12_246_1009", "HTA12_139_1002", "HTA12_139_1003", "HTA12_140_1000", "HTA12_140_1001", "HTA12_142_1002", "HTA12_142_1003", "HTA12_142_1004", "HTA12_142_1005", "HTA12_142_1006", "HTA12_142_1007", "HTA12_142_1008", "HTA12_142_1009", "HTA12_144_1000", "HTA12_144_1001", "HTA12_145_1002", "HTA12_145_1003", "HTA12_248_1016", "HTA12_248_1017", "HTA12_248_1018", "HTA12_248_1019", "HTA12_248_1020", "HTA12_248_1021", "HTA12_249_1010", "HTA12_249_1011", "HTA12_249_1012", "HTA12_249_1013", "HTA12_250_1008", "HTA12_250_1009", "HTA12_251_1010", "HTA12_251_1011", "HTA12_140_1002", "HTA12_140_1003", "HTA12_140_1004", "HTA12_140_1005", "HTA12_140_1006", "HTA12_140_1007", "HTA12_140_1008", "HTA12_140_1009", "HTA12_129_1008", "HTA12_129_1009", "HTA12_129_1014", "HTA12_134_1014", "HTA12_134_1015", "HTA12_134_1016", "HTA12_134_1017", "HTA12_135_1026", "HTA12_135_1027", "HTA12_135_1028", "HTA12_135_1029", "HTA12_135_1030", "HTA12_135_1031", "HTA12_246_1010", "HTA12_139_1004", "HTA12_140_1014", "HTA12_142_1014", "HTA12_142_1015", "HTA12_142_1016", "HTA12_142_1017", "HTA12_144_1002", "HTA12_145_1004", "HTA12_248_1022", "HTA12_248_1023", "HTA12_248_1024", "HTA12_249_1014", "HTA12_249_1015", "HTA12_250_1010", "HTA12_251_1012", "HTA12_140_1015", "HTA12_140_1016", "HTA12_140_1017", "HTA12_140_1018", "HTA12_129_2000", "HTA12_129_2001", "HTA12_129_2002", "HTA12_134_2000", "HTA12_134_2001", "HTA12_134_2002", "HTA12_134_2003", "HTA12_135_2000", "HTA12_135_2001", "HTA12_135_2002", "HTA12_135_2003", "HTA12_135_2004", "HTA12_135_2005", "HTA12_246_2001", "HTA12_139_2000", "HTA12_140_2000", "HTA12_142_2000", "HTA12_142_2001", "HTA12_142_2002", "HTA12_142_2003", "HTA12_144_2000", "HTA12_145_2000", "HTA12_248_2001", "HTA12_248_2002", "HTA12_248_2003", "HTA12_249_2001", "HTA12_249_2002", "HTA12_250_2001", "HTA12_251_2001", "HTA12_140_2001", "HTA12_140_2002", "HTA12_140_2003", "HTA12_140_2004", "HTA12_135_3000", "HTA12_140_3000", "HTA12_129_3003", "HTA12_142_3000", "HTA12_135_3001", "HTA12_142_3001", "HTA12_129_3004", "HTA12_250_3004", "HTA12_135_3002", "HTA12_129_3005", "HTA12_140_3001", "HTA12_140_3002", "HTA12_140_3003", "HTA12_140_3004", "HTA12_140_3005", "HTA12_145_3000", "HTA12_139_3000", "HTA12_129_3006", "HTA12_248_3004", "HTA12_139_3001", "HTA12_140_3006", "HTA12_248_3005", "HTA12_134_3000", "HTA12_142_3002", "HTA12_142_3003", "HTA12_142_3004", 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"Eutils Title": "Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.", "Eutils Journal": "Nature cancer", "Eutils Sort Date": "2024/11/01 00:00", "Eutils Authors": "Iglesia MD, Jayasinghe RG, Chen S, Terekhanova NV, Herndon JM, Storrs E, Karpova A, Zhou DC, Naser Al Deen N, Shinkle AT, Lu RJ, Caravan W, Houston A, Zhao Y, Sato K, Lal P, Street C, Martins Rodrigues F, Southard-Smith AN, Targino da Costa ALN, Zhu H, Mo CK, Crowson L, Fulton RS, Wyczalkowski MA, Fronick CC, Fulton LA, Sun H, Davies SR, Appelbaum EL, Chasnoff SE, Carmody M, Brooks C, Liu R, Wendl MC, Oh C, Bender D, Cruchaga C, Harari O, Bredemeyer A, Lavine K, Bose R, Margenthaler J, Held JM, Achilefu S, Ademuyiwa F, Aft R, Ma C, Colditz GA, Ju T, Oh ST, Fitzpatrick J, Hwang ES, Shoghi KI, Chheda MG, Veis DJ, Chen F, Fields RC, Gillanders WE, Ding L", "Eutils DOI": "10.1038/s43018-024-00773-6", "Cited In Number": 13, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478117" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233303", "HTAN Center ID": "HTA12", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41586-024-08087-4", "Title": "Tumour evolution and microenvironment interactions in 2D and 3D space", "Authors": "Chia-Kuei Mo, Jingxian Liu, Siqi Chen, Erik Storrs, Andre Luiz N. Targino da Costa, Andrew Houston, Michael C. Wendl, Reyka G. Jayasinghe, Michael D. Iglesia, Cong Ma, John M. Herndon, Austin N. Southard-Smith, Xinhao Liu, Jacqueline Mudd, Alla Karpova, Andrew Shinkle, S. Peter Goedegebuure, Abdurrahman Taha Mousa Ali Abdelzaher, Peng Bo, Lauren Fulghum, Samantha Livingston, Metin Balaban, Angela Hill, Joseph E. Ippolito, Vesteinn Thorsson, Jason M. Held, Ian S. Hagemann, Eric H. Kim, Peter O. Bayguinov, Albert H. Kim, Mary M. Mullen, Kooresh I. Shoghi, Tao Ju, Melissa A. Reimers, Cody Weimholt, Liang-I Kang, Sidharth V. Puram, Deborah J. Veis, Russell Pachynski, Katherine C. Fuh, Milan G. Chheda, William E. Gillanders, Ryan C. Fields, Benjamin J. Raphael, Feng Chen, Li Ding", "Corresponding Author": "Ryan C Fields,Li Ding", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3655-5783,https://orcid.org/0000-0001-6176-8943,https://orcid.org/0000-0003-1517-2975", "Year of Publication": "2024", "Location of Publication": "Nature", "Publication Abstract": "To study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined \u2018tumour microregions\u2019 as spatially distinct cancer cell clusters separated by stromal components. They varied in size and density among cancer types, with the largest microregions observed in metastatic samples. We further grouped microregions with shared genetic alterations into \u2018spatial subclones\u2019. Thirty five tumour sections exhibited subclonal structures. Spatial subclones with distinct copy number variations and mutations displayed differential oncogenic activities. We identified increased metabolic activity at the centre and increased antigen presentation along the leading edges of microregions. We also observed variable T\u2009cell infiltrations within microregions and macrophages predominantly residing at tumour boundaries. We reconstructed 3D tumour structures by co-registering 48 serial ST sections from 16 samples, which provided insights into the spatial organization and heterogeneity of tumours. Additionally, using an unsupervised deep-learning algorithm and integrating ST and CODEX data, we identified both immune hot and cold neighbourhoods and enhanced immune exhaustion markers surrounding the 3D subclones. These findings contribute to the understanding of spatial tumour evolution through interactions with the local microenvironment in 2D and 3D space, providing valuable insights into tumour biology.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/39478210/", "Publication contains HTAN ID": "Yes", "Data Type": "10X Visium,Bulk RNA-seq,scRNA-seq,scATAC-seq", "Tool": "Yes", "Supporting Link": "https://github.com/ding-lab/ST_subclone_publication,https://github.com/ding-lab/mushroom/tree/subclone-resubmission,https://github.com/estorrs/multiplex-imaging-pipeline,https://github.com/ding-lab/morph", "Supporting Link Description": "All bioinformatics programs used in this study can be accessed from the GitHub public repository.^^^The code for 3D neighbourhood identification and construction is available at GitHub.^^^The code for multiplex imaging processing is hosted at GitHub.^^^The code for Morph is accessible at GitHub.", "Publication-associated HTAN Parent Data File ID": [ 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"HTA12_258_2001", "HTA12_258_3001", "HTA12_258_3002", "HTA12_258_3003", "HTA12_258_3004", "HTA12_258_3005", "HTA12_258_3006", "HTA12_258_4001", "HTA12_259_1006", "HTA12_259_1007", "HTA12_259_1008", "HTA12_259_1009", "HTA12_259_1010", "HTA12_259_1011", "HTA12_259_1001", "HTA12_259_1002", "HTA12_259_2001", "HTA12_259_3001", "HTA12_259_3002", "HTA12_259_3003", "HTA12_259_4001", "HTA12_259_1005", "HTA12_259_1003", "HTA12_259_1004", "HTA12_259_2002", "HTA12_259_3004", "HTA12_259_3005", "HTA12_259_3006", "HTA12_259_3007", "HTA12_259_3008", "HTA12_259_3009", "HTA12_259_4002", "HTA12_260_1011", "HTA12_260_1012", "HTA12_260_1007", "HTA12_260_1008", "HTA12_260_1009", "HTA12_260_1010", "HTA12_260_1005", "HTA12_260_1001", "HTA12_260_1002", "HTA12_260_2001", "HTA12_260_3001", "HTA12_260_3002", "HTA12_260_3003", "HTA12_260_3004", "HTA12_260_3005", "HTA12_260_3006", "HTA12_260_4001", "HTA12_260_1006", "HTA12_260_1003", "HTA12_260_1004", "HTA12_260_2002", "HTA12_260_3007", "HTA12_260_3008", "HTA12_260_3009", "HTA12_260_3010", "HTA12_260_3011", "HTA12_260_3012", "HTA12_260_4002", "HTA12_261_1003", "HTA12_261_1001", "HTA12_261_1002", "HTA12_261_2001", "HTA12_261_3002", "HTA12_261_3001", "HTA12_261_3003", "HTA12_261_3004", "HTA12_261_3005", "HTA12_261_3006", "HTA12_261_4001", "HTA12_262_2003", "HTA12_262_1005", "HTA12_262_1003", "HTA12_262_1004", "HTA12_262_2002", "HTA12_262_3005", "HTA12_262_3004", "HTA12_262_3006", "HTA12_262_3007", "HTA12_262_3008", "HTA12_262_3009", "HTA12_262_4002", "HTA12_262_1001", "HTA12_262_1002", "HTA12_262_2001", "HTA12_262_3001", "HTA12_262_3002", "HTA12_262_3003", "HTA12_262_4001", "HTA12_263_2007", "HTA12_263_1015", "HTA12_263_1001", "HTA12_263_1002", "HTA12_263_2004", "HTA12_263_3001", "HTA12_263_3002", "HTA12_263_3003", "HTA12_263_3004", "HTA12_263_3005", "HTA12_263_3006", "HTA12_263_4004", "HTA12_263_1016", "HTA12_263_1004", "HTA12_263_1003", "HTA12_263_1006", "HTA12_263_1005", "HTA12_263_2005", "HTA12_263_3007", "HTA12_263_3008", "HTA12_263_3009", "HTA12_263_3010", "HTA12_263_3011", "HTA12_263_3012", "HTA12_263_4005", "HTA12_263_1017", "HTA12_263_1007", "HTA12_263_1008", "HTA12_263_2001", "HTA12_263_3014", "HTA12_263_3013", "HTA12_263_3015", "HTA12_263_3016", "HTA12_263_3017", "HTA12_263_3018", "HTA12_263_4001", "HTA12_263_1018", "HTA12_263_1009", "HTA12_263_1010", "HTA12_263_2002", "HTA12_263_3020", "HTA12_263_3019", "HTA12_263_3021", "HTA12_263_3022", "HTA12_263_3023", "HTA12_263_3024", "HTA12_263_4002", "HTA12_263_1019", "HTA12_263_1011", "HTA12_263_1012", "HTA12_263_2003", "HTA12_263_3026", "HTA12_263_3025", "HTA12_263_3027", "HTA12_263_3028", "HTA12_263_3029", "HTA12_263_3030", "HTA12_263_4003", "HTA12_263_1020", "HTA12_263_1013", "HTA12_263_1014", "HTA12_263_2006", "HTA12_263_3031", "HTA12_263_3032", "HTA12_263_3033", "HTA12_263_3034", "HTA12_263_3035", "HTA12_263_3036", "HTA12_263_4006", "HTA12_264_1006", "HTA12_264_1007", "HTA12_264_1005", "HTA12_264_1001", "HTA12_264_1002", "HTA12_264_1003", "HTA12_264_1004", "HTA12_264_2001", "HTA12_264_3002", "HTA12_264_3001", "HTA12_264_3003", "HTA12_264_3004", "HTA12_264_3005", "HTA12_264_3006", "HTA12_264_4001", "HTA12_264_1008", "HTA12_264_1009", "HTA12_264_1010", "HTA12_264_1011", "HTA12_265_1005", "HTA12_265_1001", "HTA12_265_1002", "HTA12_265_1003", "HTA12_265_1004", "HTA12_265_2001", "HTA12_265_3001", "HTA12_265_3002", "HTA12_265_3003", "HTA12_265_3004", "HTA12_265_3005", "HTA12_265_3006", "HTA12_265_4001", "HTA12_266_1008", "HTA12_266_1010", "HTA12_266_1009", "HTA12_266_1011", "HTA12_266_1012", "HTA12_266_1014", "HTA12_266_1013", "HTA12_266_1015", "HTA12_266_1016", "HTA12_266_1017", "HTA12_266_1001", "HTA12_266_1003", "HTA12_266_1002", "HTA12_266_1004", "HTA12_266_2001", "HTA12_266_3001", "HTA12_266_3002", "HTA12_266_3003", "HTA12_266_4001", "HTA12_266_1007", "HTA12_266_1005", "HTA12_266_1006", "HTA12_266_2002", "HTA12_266_3005", "HTA12_266_3004", "HTA12_266_3006", "HTA12_266_3007", "HTA12_266_3008", "HTA12_266_3009", "HTA12_266_4002", "HTA12_267_1005", "HTA12_267_1001", "HTA12_267_1002", "HTA12_267_1004", "HTA12_267_1003", "HTA12_267_2001", "HTA12_267_3001", "HTA12_267_3002", "HTA12_267_3003", "HTA12_267_3004", "HTA12_267_3005", "HTA12_267_3006", "HTA12_267_4001", "HTA12_268_1006", "HTA12_268_1007", "HTA12_268_1005", "HTA12_268_1001", "HTA12_268_1002", "HTA12_268_1004", "HTA12_268_1003", "HTA12_268_2001", "HTA12_268_3002", "HTA12_268_3001", "HTA12_268_3003", "HTA12_268_3004", "HTA12_268_3005", "HTA12_268_3006", "HTA12_268_4001", "HTA12_269_1005", "HTA12_269_1001", "HTA12_269_1002", "HTA12_269_2001", "HTA12_269_3002", "HTA12_269_3001", "HTA12_269_3003", "HTA12_269_3004", "HTA12_269_3005", "HTA12_269_3006", "HTA12_269_4001", "HTA12_269_1006", "HTA12_269_1003", "HTA12_269_1004", "HTA12_269_2002", "HTA12_269_3008", "HTA12_269_3007", "HTA12_269_3009", "HTA12_269_3010", "HTA12_269_3011", "HTA12_269_3012", "HTA12_269_4002", "HTA12_269_2003", "HTA12_269_2004", "HTA12_270_1013", "HTA12_270_1014", "HTA12_270_1017", "HTA12_270_1018", "HTA12_270_1003", "HTA12_270_1004", "HTA12_270_2002", "HTA12_270_3004", "HTA12_270_3005", "HTA12_270_3006", "HTA12_270_4002", "HTA12_270_1011", "HTA12_270_1005", "HTA12_270_1006", "HTA12_270_1007", "HTA12_270_1008", "HTA12_270_2003", "HTA12_270_3008", "HTA12_270_3007", "HTA12_270_3009", "HTA12_270_3010", "HTA12_270_3011", "HTA12_270_3012", "HTA12_270_4003", "HTA12_270_1001", "HTA12_270_1002", "HTA12_270_2001", "HTA12_270_3001", "HTA12_270_3002", "HTA12_270_3003", "HTA12_270_4001", "HTA12_270_1012", "HTA12_270_1009", "HTA12_270_1010", "HTA12_270_2004", "HTA12_270_3014", "HTA12_270_3013", "HTA12_270_3015", "HTA12_270_3016", "HTA12_270_3017", "HTA12_270_3018", "HTA12_270_4004", "HTA12_270_1015", "HTA12_270_1016", "HTA12_270_1019", "HTA12_270_1020", "HTA12_271_1006", "HTA12_271_1007", "HTA12_271_1008", "HTA12_271_1009", "HTA12_271_1010", "HTA12_271_1011", "HTA12_271_1001", "HTA12_271_1002", "HTA12_271_2001", "HTA12_271_3001", "HTA12_271_3002", "HTA12_271_3003", "HTA12_271_4001", "HTA12_271_1005", "HTA12_271_1003", "HTA12_271_1004", "HTA12_271_2002", "HTA12_271_3005", "HTA12_271_3004", "HTA12_271_3006", "HTA12_271_3007", "HTA12_271_3008", "HTA12_271_3009", "HTA12_271_4002", "HTA12_272_1001", "HTA12_272_1002", "HTA12_272_2001", "HTA12_272_3001", "HTA12_272_3002", "HTA12_272_3003", "HTA12_272_4001", "HTA12_272_1005", "HTA12_272_1003", "HTA12_272_1004", "HTA12_272_2002", "HTA12_272_3004", "HTA12_272_3005", "HTA12_272_3006", "HTA12_272_3007", "HTA12_272_3008", "HTA12_272_3009", "HTA12_272_4002", "HTA12_272_1006", "HTA12_272_1007", "HTA12_272_1008", "HTA12_272_1009", "HTA12_255_2004", "HTA12_273_1003", "HTA12_273_1001", "HTA12_273_1002", "HTA12_273_2001", "HTA12_273_3002", "HTA12_273_3001", "HTA12_273_3003", "HTA12_273_3004", "HTA12_273_3005", "HTA12_273_3006", "HTA12_273_4001", "HTA12_274_1003", "HTA12_274_1001", "HTA12_274_1002", "HTA12_274_2001", "HTA12_274_3001", "HTA12_274_3002", "HTA12_274_3003", "HTA12_274_3004", "HTA12_274_3005", "HTA12_274_3006", "HTA12_274_4001", "HTA12_275_1003", "HTA12_275_1001", "HTA12_275_1002", "HTA12_275_2001", "HTA12_275_3001", "HTA12_275_3002", "HTA12_275_3003", "HTA12_275_3004", "HTA12_275_3005", "HTA12_275_3006", "HTA12_275_4001", "HTA12_276_2002", "HTA12_276_1005", "HTA12_276_1001", "HTA12_276_1002", "HTA12_276_1003", "HTA12_276_1004", "HTA12_276_2001", "HTA12_276_3002", "HTA12_276_3001", "HTA12_276_3003", "HTA12_276_3004", "HTA12_276_3005", "HTA12_276_3006", "HTA12_276_4001", "HTA12_277_1005", "HTA12_277_1001", "HTA12_277_1002", "HTA12_277_1003", "HTA12_277_1004", "HTA12_277_2001", "HTA12_277_3001", "HTA12_277_3002", "HTA12_277_3003", "HTA12_277_3004", "HTA12_277_3005", "HTA12_277_3006", "HTA12_277_4001", "HTA12_278_1005", "HTA12_278_1001", "HTA12_278_1002", "HTA12_278_1003", "HTA12_278_1004", "HTA12_278_2001", "HTA12_278_3001", "HTA12_278_3002", "HTA12_278_3003", "HTA12_278_3004", "HTA12_278_3005", "HTA12_278_3006", "HTA12_278_4001", "HTA12_279_2002", "HTA12_279_1005", "HTA12_279_1001", "HTA12_279_1002", "HTA12_279_1003", "HTA12_279_1004", "HTA12_279_2001", "HTA12_279_3002", "HTA12_279_3001", "HTA12_279_3003", "HTA12_279_3004", "HTA12_279_3005", "HTA12_279_3006", "HTA12_279_4001", "HTA12_280_2004", "HTA12_280_2003", "HTA12_280_1007", "HTA12_280_1001", "HTA12_280_1002", "HTA12_280_2001", "HTA12_280_3002", "HTA12_280_3001", "HTA12_280_3003", "HTA12_280_3004", "HTA12_280_3005", "HTA12_280_3006", "HTA12_280_4001", "HTA12_280_1008", "HTA12_280_1003", "HTA12_280_1004", "HTA12_280_1005", "HTA12_280_1006", "HTA12_280_2002", "HTA12_280_3007", "HTA12_280_3008", "HTA12_280_3009", "HTA12_280_3010", "HTA12_280_3011", "HTA12_280_3012", "HTA12_280_4002", "HTA12_281_1005", "HTA12_281_1001", "HTA12_281_1002", "HTA12_281_1003", "HTA12_281_1004", "HTA12_281_2001", "HTA12_281_3002", "HTA12_281_3001", "HTA12_281_3003", "HTA12_281_3004", "HTA12_281_3005", "HTA12_281_3006", "HTA12_281_4001", "HTA12_282_1003", "HTA12_282_1001", "HTA12_282_1002", "HTA12_282_2001", "HTA12_282_3001", "HTA12_282_3002", "HTA12_282_3003", "HTA12_282_3004", "HTA12_282_3005", "HTA12_282_3006", "HTA12_282_4001", "HTA12_283_1003", "HTA12_283_1001", "HTA12_283_1002", "HTA12_283_2001", "HTA12_283_3001", "HTA12_283_3002", "HTA12_283_3003", "HTA12_283_3004", "HTA12_283_3005", "HTA12_283_3006", "HTA12_283_4001", "HTA12_284_1005", "HTA12_284_1001", "HTA12_284_1002", "HTA12_284_1003", "HTA12_284_1004", "HTA12_284_2001", "HTA12_284_3002", "HTA12_284_3001", "HTA12_284_3003", "HTA12_284_3004", "HTA12_284_3005", "HTA12_284_3006", "HTA12_284_4001", "HTA12_285_1003", "HTA12_285_1001", "HTA12_285_1002", "HTA12_285_2001", "HTA12_285_3001", "HTA12_285_3002", "HTA12_285_3003", "HTA12_285_3004", "HTA12_285_3005", "HTA12_285_3006", "HTA12_285_4001", "HTA12_286_1003", "HTA12_286_1001", "HTA12_286_1002", "HTA12_286_2001", "HTA12_286_3001", "HTA12_286_3002", "HTA12_286_3003", "HTA12_286_3004", "HTA12_286_3005", "HTA12_286_3006", "HTA12_286_4001", "HTA12_287_1005", "HTA12_287_1001", "HTA12_287_1002", "HTA12_287_1003", "HTA12_287_1004", "HTA12_287_2001", "HTA12_287_3002", "HTA12_287_3001", "HTA12_287_3003", "HTA12_287_3004", "HTA12_287_3005", "HTA12_287_3006", "HTA12_287_4001", "HTA12_288_1003", "HTA12_288_1001", "HTA12_288_1002", "HTA12_288_2001", "HTA12_288_3001", "HTA12_288_3002", "HTA12_288_3003", "HTA12_288_3004", "HTA12_288_3005", "HTA12_288_3006", "HTA12_288_4001", "HTA12_289_1003", "HTA12_289_1001", "HTA12_289_1002", "HTA12_289_2001", "HTA12_289_3001", "HTA12_289_3002", "HTA12_289_3003", "HTA12_289_3004", "HTA12_289_3005", "HTA12_289_3006", "HTA12_289_4001", "HTA12_290_1003", "HTA12_290_1001", "HTA12_290_1002", "HTA12_290_2001", "HTA12_290_3001", "HTA12_290_3002", "HTA12_290_3003", "HTA12_290_3004", "HTA12_290_3005", "HTA12_290_3006", "HTA12_290_4001", "HTA12_291_1003", "HTA12_291_1001", "HTA12_291_1002", "HTA12_291_2001", "HTA12_291_3001", "HTA12_291_3002", "HTA12_291_3003", "HTA12_291_3004", "HTA12_291_3005", "HTA12_291_3006", "HTA12_291_4001", "HTA12_292_1003", "HTA12_292_1001", "HTA12_292_1002", "HTA12_292_2001", "HTA12_292_3001", "HTA12_292_3002", "HTA12_292_3003", "HTA12_292_3004", "HTA12_292_3005", "HTA12_292_3006", "HTA12_292_4001", "HTA12_294_1003", "HTA12_294_1001", "HTA12_294_1002", "HTA12_294_2001", "HTA12_294_3002", "HTA12_294_3001", "HTA12_294_3003", "HTA12_294_3004", "HTA12_294_3005", "HTA12_294_3006", "HTA12_294_4001", "HTA12_295_1005", "HTA12_295_1003", "HTA12_295_1001", "HTA12_295_1002", "HTA12_295_1004", "HTA12_295_2001", "HTA12_295_3001", "HTA12_295_3002", "HTA12_295_3003", "HTA12_295_3004", "HTA12_295_3005", "HTA12_295_3006", "HTA12_295_4001", "HTA12_296_1003", "HTA12_296_1001", "HTA12_296_1002", "HTA12_296_2001", "HTA12_296_3001", "HTA12_296_3002", "HTA12_296_3003", "HTA12_296_3004", "HTA12_296_3005", "HTA12_296_3006", "HTA12_296_4001", "HTA12_297_1003", "HTA12_297_1001", "HTA12_297_1002", "HTA12_297_2001", "HTA12_297_3001", "HTA12_297_3002", "HTA12_297_3003", "HTA12_297_3004", "HTA12_297_3005", "HTA12_297_3006", "HTA12_297_4001", "HTA12_298_1003", "HTA12_298_1001", "HTA12_298_1002", "HTA12_298_2001", "HTA12_298_3001", "HTA12_298_3002", "HTA12_298_3003", "HTA12_298_3004", "HTA12_298_3005", "HTA12_298_3006", "HTA12_298_4001", "HTA12_129_1029", "HTA12_129_1030", "HTA12_129_1019", "HTA12_129_1015", "HTA12_129_1016", "HTA12_129_2007", "HTA12_129_3025", "HTA12_129_3026", "HTA12_129_3027", "HTA12_129_3028", "HTA12_129_3029", "HTA12_129_3030", "HTA12_129_4002", "HTA12_129_1025", "HTA12_129_1026", "HTA12_129_1024", "HTA12_129_1017", "HTA12_129_1018", "HTA12_129_2008", "HTA12_129_3031", "HTA12_129_3032", "HTA12_129_3033", "HTA12_129_3034", "HTA12_129_3035", "HTA12_129_3036", "HTA12_129_4003", "HTA12_129_1027", "HTA12_129_1028", "HTA12_132_1017", "HTA12_132_1005", "HTA12_132_1006", "HTA12_132_2003", "HTA12_132_3013", "HTA12_132_3014", "HTA12_132_3015", "HTA12_132_3016", "HTA12_132_3017", "HTA12_132_3018", "HTA12_132_4003", "HTA12_132_1018", "HTA12_132_1007", "HTA12_132_1008", "HTA12_132_2004", "HTA12_132_3019", "HTA12_132_3024", "HTA12_132_3025", "HTA12_132_3026", "HTA12_132_3027", "HTA12_132_3028", "HTA12_132_4004", "HTA12_132_1019", "HTA12_132_1009", "HTA12_132_1014", "HTA12_132_2005", "HTA12_132_3029", "HTA12_132_3030", "HTA12_132_3031", "HTA12_132_3032", "HTA12_132_3033", "HTA12_132_3034", "HTA12_132_4006", "HTA12_134_4002", "HTA12_134_4003", "HTA12_135_4003", "HTA12_135_4004", "HTA12_135_4006", "HTA12_135_4007", "HTA12_135_4008", "HTA12_135_4009", "HTA12_135_1032", "HTA12_135_1033", "HTA12_135_1034", "HTA12_135_2013", "HTA12_135_3040", "HTA12_135_3041", "HTA12_135_3042", "HTA12_135_4002", "HTA12_140_1019", "HTA12_140_1023", "HTA12_142_4003", "HTA12_142_4004", "HTA12_142_4006", "HTA12_248_4004", "HTA12_248_4005", "HTA12_248_1030", "HTA12_248_1028", "HTA12_248_1029", "HTA12_248_2010", "HTA12_248_3022", "HTA12_248_3023", "HTA12_248_3024", "HTA12_248_3025", "HTA12_248_3026", "HTA12_248_3027", "HTA12_248_4002", "HTA12_249_2008", "HTA12_250_1016", "HTA12_250_1014", "HTA12_250_1015", "HTA12_250_2007", "HTA12_250_3010", "HTA12_250_3011", "HTA12_250_3012", "HTA12_250_3013", "HTA12_250_3014", "HTA12_250_3015", "HTA12_250_4002", "HTA12_253_1017", "HTA12_253_1007", "HTA12_253_1008", "HTA12_253_2008", "HTA12_253_3017", "HTA12_253_3016", "HTA12_253_3018", "HTA12_253_3019", "HTA12_253_3020", "HTA12_253_3021", "HTA12_253_4003", "HTA12_253_1018", "HTA12_253_1009", "HTA12_253_1010", "HTA12_253_2009", "HTA12_253_3023", "HTA12_253_3022", "HTA12_253_3024", "HTA12_253_3025", "HTA12_253_3026", "HTA12_253_3027", "HTA12_253_4004", "HTA12_253_1019", "HTA12_253_1011", "HTA12_253_1012", "HTA12_253_2010", "HTA12_253_3029", "HTA12_253_3028", "HTA12_253_3030", "HTA12_253_3031", "HTA12_253_3032", "HTA12_253_3033", "HTA12_253_4005", "HTA12_253_1020", "HTA12_253_1013", "HTA12_253_1014", "HTA12_253_2012", "HTA12_253_3034", "HTA12_253_3035", "HTA12_253_3036", "HTA12_253_3037", "HTA12_253_3038", "HTA12_253_3039", "HTA12_253_4007", "HTA12_253_1025", "HTA12_253_1027", "HTA12_253_1026", "HTA12_253_1028", "HTA12_253_1031", "HTA12_253_1032", "HTA12_253_1001", "HTA12_253_1002", "HTA12_253_2006", "HTA12_253_3001", "HTA12_253_3002", "HTA12_253_3003", "HTA12_253_4001", "HTA12_253_1029", "HTA12_253_1030", "HTA12_22_1001", "HTA12_22_1002", "HTA12_22_1004", "HTA12_22_1003", "HTA12_22_1005", "HTA12_22_1006", "HTA12_22_1007", "HTA12_22_1008", "HTA12_22_1009", "HTA12_22_1010", "HTA12_23_1001", "HTA12_23_1002", "HTA12_23_1003", "HTA12_23_1004", "HTA12_23_1005", "HTA12_23_1006", "HTA12_23_1007", "HTA12_23_1008", "HTA12_23_1009", "HTA12_23_1010", "HTA12_24_1001", "HTA12_24_1002", "HTA12_24_1004", "HTA12_24_1003", "HTA12_24_1005", "HTA12_24_1006", "HTA12_24_1007", "HTA12_24_1008", "HTA12_25_1001", "HTA12_25_1002", "HTA12_25_1003", "HTA12_25_1004", "HTA12_25_1005", "HTA12_25_1006", "HTA12_25_1007", "HTA12_25_1008", "HTA12_25_1009", "HTA12_25_1010", "HTA12_25_1011", "HTA12_25_1012", "HTA12_25_1013", "HTA12_25_1014", "HTA12_25_1015", "HTA12_25_1016", "HTA12_26_1001", "HTA12_26_1002", "HTA12_26_1003", "HTA12_26_1004", "HTA12_26_1005", "HTA12_26_1006", "HTA12_26_1007", "HTA12_26_1008", "HTA12_26_1009", "HTA12_26_1010", "HTA12_26_1011", "HTA12_26_1012", "HTA12_27_1002", "HTA12_27_1001", "HTA12_27_1003", "HTA12_27_1004", "HTA12_27_1005", "HTA12_27_1006", "HTA12_27_1007", "HTA12_27_1008", "HTA12_27_1009", "HTA12_27_1010", "HTA12_28_1001", "HTA12_28_1002", "HTA12_28_1004", "HTA12_28_1003", "HTA12_28_1005", "HTA12_28_1006", "HTA12_28_1007", "HTA12_28_1008", "HTA12_29_1001", "HTA12_29_1002", "HTA12_29_1003", "HTA12_29_1004", "HTA12_29_1005", "HTA12_29_1006", "HTA12_29_1008", "HTA12_29_1007", "HTA12_29_1009", "HTA12_29_1010", "HTA12_30_1002", "HTA12_30_1001", "HTA12_30_1003", "HTA12_30_1004", "HTA12_30_1005", "HTA12_30_1006", "HTA12_30_1007", "HTA12_30_1008", "HTA12_30_1009", "HTA12_30_1010", "HTA12_31_1002", "HTA12_30_6", "HTA12_31_1003", "HTA12_31_1004", "HTA12_31_1005", "HTA12_31_1006", "HTA12_31_1007", "HTA12_31_1008", "HTA12_31_1009", "HTA12_31_1010", "HTA12_22_1020", "HTA12_22_1021", "HTA12_22_1022", "HTA12_22_2010", "HTA12_22_3020", "HTA12_22_3021", "HTA12_22_3022", "HTA12_22_3023", "HTA12_22_1012", "HTA12_22_1013", "HTA12_22_2001", "HTA12_22_2020", "HTA12_22_3001", "HTA12_22_3002", "HTA12_22_3003", "HTA12_22_1011", "HTA12_22_3007", "HTA12_22_3008", "HTA12_22_2002", "HTA12_22_3004", "HTA12_22_3005", "HTA12_22_3006", "HTA12_22_3009", "HTA12_23_1020", "HTA12_23_1021", "HTA12_23_1022", "HTA12_23_2010", "HTA12_23_3020", "HTA12_23_3021", "HTA12_23_3022", "HTA12_23_3023", "HTA12_23_1040", "HTA12_23_1041", "HTA12_23_2001", "HTA12_23_2020", "HTA12_23_3001", "HTA12_23_3002", "HTA12_23_3003", "HTA12_23_1011", "HTA12_23_3007", "HTA12_23_3008", "HTA12_23_2002", "HTA12_23_3004", "HTA12_23_3005", "HTA12_23_3006", "HTA12_23_3009", "HTA12_24_1020", "HTA12_24_1021", "HTA12_24_1022", "HTA12_24_2010", "HTA12_24_3020", "HTA12_24_3021", "HTA12_24_3022", "HTA12_24_3023", "HTA12_24_1040", "HTA12_24_1041", "HTA12_24_2001", "HTA12_24_2020", "HTA12_24_3001", "HTA12_24_3002", "HTA12_24_3003", "HTA12_25_1021", "HTA12_25_1022", "HTA12_25_1023", "HTA12_25_1024", "HTA12_25_1025", "HTA12_25_1026", "HTA12_25_2010", "HTA12_25_3120", "HTA12_25_3121", "HTA12_25_3122", "HTA12_25_3123", "HTA12_25_1040", "HTA12_25_1041", "HTA12_25_2001", "HTA12_25_2020", "HTA12_25_3001", "HTA12_25_3002", "HTA12_25_3003", "HTA12_25_1017", "HTA12_25_3007", "HTA12_25_3008", "HTA12_25_2002", "HTA12_25_3004", "HTA12_25_3005", "HTA12_25_3006", "HTA12_25_3009", "HTA12_25_1018", "HTA12_25_3013", "HTA12_25_3014", "HTA12_25_2003", "HTA12_25_3010", "HTA12_25_3011", "HTA12_25_3012", "HTA12_25_3015", "HTA12_25_1019", "HTA12_25_3019", "HTA12_25_3020", "HTA12_25_2004", "HTA12_25_3016", "HTA12_25_3017", "HTA12_25_3018", "HTA12_25_3021", "HTA12_25_1020", "HTA12_25_3025", "HTA12_25_3026", "HTA12_25_2005", "HTA12_25_3022", "HTA12_25_3023", "HTA12_25_3024", "HTA12_25_3027", "HTA12_26_1020", "HTA12_26_1021", "HTA12_26_1022", "HTA12_26_2010", "HTA12_26_3020", "HTA12_26_3021", "HTA12_26_3022", "HTA12_26_3023", "HTA12_26_1040", "HTA12_26_1041", "HTA12_26_2001", "HTA12_26_2020", "HTA12_26_3001", "HTA12_26_3002", "HTA12_26_3003", "HTA12_26_1013", "HTA12_26_3007", "HTA12_26_3008", "HTA12_26_2002", "HTA12_26_3004", "HTA12_26_3005", "HTA12_26_3006", "HTA12_26_3009", "HTA12_26_1014", "HTA12_26_3013", "HTA12_26_3014", "HTA12_26_2003", "HTA12_26_3010", "HTA12_26_3011", "HTA12_26_3012", "HTA12_26_3015", "HTA12_27_1020", "HTA12_27_1021", "HTA12_27_1022", "HTA12_27_1023", "HTA12_27_1024", "HTA12_27_1025", "HTA12_27_2010", "HTA12_27_3020", "HTA12_27_3021", "HTA12_27_3022", "HTA12_27_3023", "HTA12_27_1040", "HTA12_27_1041", "HTA12_27_2001", "HTA12_27_2020", "HTA12_27_3001", "HTA12_27_3002", "HTA12_27_3003", "HTA12_27_1011", "HTA12_27_3007", "HTA12_27_3008", "HTA12_27_2002", "HTA12_27_3004", "HTA12_27_3005", "HTA12_27_3006", "HTA12_27_3009", "HTA12_28_1020", "HTA12_28_1021", "HTA12_28_1022", "HTA12_28_1023", "HTA12_28_1024", "HTA12_28_1025", "HTA12_28_2010", "HTA12_28_3020", "HTA12_28_3022", "HTA12_28_3024", "HTA12_28_3026", "HTA12_28_1040", "HTA12_28_1041", "HTA12_28_2001", "HTA12_28_2020", "HTA12_28_3001", "HTA12_28_3002", "HTA12_28_3003", "HTA12_29_2001", "HTA12_29_3001", "HTA12_29_3002", "HTA12_29_3003", "HTA12_29_1011", "HTA12_29_3007", "HTA12_29_3008", "HTA12_29_2002", "HTA12_29_3004", "HTA12_29_3005", "HTA12_29_3006", "HTA12_29_3009", "HTA12_30_1020", "HTA12_30_1021", "HTA12_30_1022", "HTA12_30_2010", "HTA12_30_3020", "HTA12_30_3021", "HTA12_30_3022", "HTA12_30_3023", "HTA12_30_1040", "HTA12_30_1041", "HTA12_30_2001", "HTA12_30_2020", "HTA12_30_3001", "HTA12_30_3002", "HTA12_30_3003", "HTA12_30_1012", "HTA12_30_3007", "HTA12_30_3008", "HTA12_30_2002", "HTA12_30_3004", "HTA12_30_3005", "HTA12_30_3006", "HTA12_30_3009", "HTA12_31_1020", "HTA12_31_1021", "HTA12_31_1022", "HTA12_31_2010", "HTA12_31_3020", "HTA12_31_3021", "HTA12_31_3022", "HTA12_31_3023", "HTA12_31_1040", "HTA12_31_1041", "HTA12_31_2001", "HTA12_31_2020", "HTA12_31_3001", "HTA12_31_3002", "HTA12_31_3003", "HTA12_31_1011", "HTA12_31_3007", "HTA12_31_3008", "HTA12_31_2002", "HTA12_31_3004", "HTA12_31_3005", "HTA12_31_3006", "HTA12_31_3009", "HTA12_23_1110", "HTA12_23_1111", "HTA12_24_1110", "HTA12_24_1111", "HTA12_24_1112", "HTA12_24_1113", "HTA12_25_1110", "HTA12_25_1111", "HTA12_25_1112", "HTA12_25_1113", "HTA12_26_1110", "HTA12_26_1111", "HTA12_26_1112", "HTA12_26_1113", "HTA12_27_1110", "HTA12_27_1111", "HTA12_28_1110", "HTA12_28_1111", "HTA12_28_1112", "HTA12_28_1113", "HTA12_30_1110", "HTA12_30_1111", "HTA12_30_1112", "HTA12_30_1113", "HTA12_31_1110", "HTA12_31_1111", "HTA12_31_1112", "HTA12_31_1113", "HTA12_22_4000", "HTA12_22_4005", "HTA12_23_4000", "HTA12_23_4005", "HTA12_24_4000", "HTA12_24_4005", "HTA12_25_4000", "HTA12_25_4005", "HTA12_26_4000", "HTA12_26_4005", "HTA12_27_4000", "HTA12_27_4005", "HTA12_28_4000", "HTA12_28_4005", "HTA12_30_4000", "HTA12_30_4005", "HTA12_31_4000", "HTA12_31_4005", "HTA12_129_1008", "HTA12_129_1002", "HTA12_129_1003", "HTA12_129_2000", "HTA12_129_3016", "HTA12_129_3020", "HTA12_129_3008", "HTA12_129_3006", "HTA12_129_3019", "HTA12_129_3014", "HTA12_129_1009", "HTA12_129_1004", "HTA12_129_1005", "HTA12_129_2001", "HTA12_129_3017", "HTA12_129_3021", "HTA12_129_3009", "HTA12_129_3003", "HTA12_129_3005", "HTA12_129_3004", "HTA12_129_1014", "HTA12_129_1006", "HTA12_129_1007", "HTA12_129_2002", "HTA12_129_3018", "HTA12_129_3022", "HTA12_129_3023", "HTA12_129_3024", "HTA12_129_3015", "HTA12_129_3007", "HTA12_134_1016", "HTA12_134_1006", "HTA12_134_1007", "HTA12_134_2002", "HTA12_134_3008", "HTA12_134_3015", "HTA12_134_3001", "HTA12_134_3004", "HTA12_134_3000", "HTA12_134_3024", "HTA12_134_1017", "HTA12_134_1008", "HTA12_134_1009", "HTA12_134_2003", "HTA12_134_3009", "HTA12_134_3016", "HTA12_134_3013", "HTA12_134_3012", "HTA12_134_3018", "HTA12_134_3014", "HTA12_139_1004", "HTA12_139_1002", "HTA12_139_1003", "HTA12_139_2000", "HTA12_139_3003", "HTA12_139_3004", "HTA12_139_3000", "HTA12_139_3002", "HTA12_139_3005", "HTA12_139_3001", "HTA12_140_1016", "HTA12_140_1004", "HTA12_140_1005", "HTA12_140_2002", "HTA12_140_3002", "HTA12_140_3019", "HTA12_140_3008", "HTA12_140_3005", "HTA12_140_3000", "HTA12_140_3030", "HTA12_140_1017", "HTA12_140_1006", "HTA12_140_1007", "HTA12_140_2003", "HTA12_140_3003", "HTA12_140_3024", "HTA12_140_3027", "HTA12_140_3016", "HTA12_140_3029", "HTA12_140_3033", "HTA12_140_1015", "HTA12_140_1002", "HTA12_140_1003", "HTA12_140_2001", "HTA12_140_3001", "HTA12_140_3018", "HTA12_140_3009", "HTA12_140_3031", "HTA12_140_3032", "HTA12_140_3012", "HTA12_140_1018", "HTA12_140_1008", "HTA12_140_1009", "HTA12_140_2004", "HTA12_140_3004", "HTA12_140_3025", "HTA12_140_3010", "HTA12_140_3015", "HTA12_140_3014", "HTA12_140_3006", "HTA12_140_1014", "HTA12_140_1000", "HTA12_140_1001", "HTA12_140_2000", "HTA12_140_3011", "HTA12_140_3017", "HTA12_140_3013", "HTA12_140_3028", "HTA12_140_3026", "HTA12_140_3007", "HTA12_142_1014", "HTA12_142_1002", "HTA12_142_1003", "HTA12_142_2000", "HTA12_142_3006", "HTA12_142_3013", "HTA12_142_3025", "HTA12_142_3019", "HTA12_142_3001", "HTA12_142_3024", "HTA12_144_1002", "HTA12_144_1000", "HTA12_144_1001", "HTA12_144_2000", "HTA12_144_3001", "HTA12_144_3003", "HTA12_144_3004", "HTA12_144_3000", "HTA12_144_3005", "HTA12_144_3002", "HTA12_145_1004", "HTA12_145_1002", "HTA12_145_1003", "HTA12_145_2000", "HTA12_145_3003", "HTA12_145_3004", "HTA12_145_3001", "HTA12_145_3000", "HTA12_145_3002", "HTA12_145_3005", "HTA12_246_1010", "HTA12_246_1008", "HTA12_246_1009", "HTA12_246_2001", "HTA12_246_3006", "HTA12_246_3008", "HTA12_246_3004", "HTA12_246_3007", "HTA12_246_3005", "HTA12_246_3003", "HTA12_248_2005", "HTA12_248_1022", "HTA12_248_1016", "HTA12_248_1017", "HTA12_248_2001", "HTA12_248_3007", "HTA12_248_3013", "HTA12_248_3004", "HTA12_248_3006", "HTA12_248_3011", "HTA12_248_3010", "HTA12_249_1014", "HTA12_249_1010", 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"HTA12_142_2001", "HTA12_142_3007", "HTA12_142_3014", "HTA12_142_3027", "HTA12_142_3011", "HTA12_142_3017", "HTA12_142_3002", "HTA12_142_1016", "HTA12_142_1006", "HTA12_142_1007", "HTA12_142_2002", "HTA12_142_3008", "HTA12_142_3015", "HTA12_142_3003", "HTA12_142_3012", "HTA12_142_3018", "HTA12_142_3005", "HTA12_142_1017", "HTA12_142_1008", "HTA12_142_1009", "HTA12_142_2003", "HTA12_142_3009", "HTA12_142_3016", "HTA12_142_3010", "HTA12_142_3000", "HTA12_142_3004", "HTA12_142_3026", "HTA12_248_1023", "HTA12_248_1018", "HTA12_248_1019", "HTA12_248_2002", "HTA12_248_3008", "HTA12_248_3014", "HTA12_248_3021", "HTA12_248_3017", "HTA12_248_3019", "HTA12_248_3012", "HTA12_248_1024", "HTA12_248_1020", "HTA12_248_1021", "HTA12_248_2003", "HTA12_248_3009", "HTA12_248_3015", "HTA12_248_3016", "HTA12_248_3018", "HTA12_248_3020", "HTA12_248_3005", "HTA12_273_2002" ], "Eutils Date": "2024 Oct", "Eutils Title": "Tumour evolution and microenvironment interactions in 2D and 3D space.", "Eutils Journal": "Nature", "Eutils Sort Date": "2024/10/01 00:00", "Eutils Authors": "Mo CK, Liu J, Chen S, Storrs E, Targino da Costa ALN, Houston A, Wendl MC, Jayasinghe RG, Iglesia MD, Ma C, Herndon JM, Southard-Smith AN, Liu X, Mudd J, Karpova A, Shinkle A, Goedegebuure SP, Abdelzaher ATMA, Bo P, Fulghum L, Livingston S, Balaban M, Hill A, Ippolito JE, Thorsson V, Held JM, Hagemann IS, Kim EH, Bayguinov PO, Kim AH, Mullen MM, Shoghi KI, Ju T, Reimers MA, Weimholt C, Kang LI, Puram SV, Veis DJ, Pachynski R, Fuh KC, Chheda MG, Gillanders WE, Fields RC, Raphael BJ, Chen F, Ding L", "Eutils DOI": "10.1038/s41586-024-08087-4", "Cited In Number": 94, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=39478210" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233303", "HTAN Center ID": "HTA12", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41586-023-06682-5", "Title": "Epigenetic regulation during cancer transitions across 11 tumour types", "Authors": "Nadezhda V Terekhanova, Alla Karpova, Wen-Wei Liang, Alexander Strzalkowski, Siqi Chen, Yize Li, Austin N Southard-Smith, Michael D Iglesia, Michael C Wendl, Reyka G Jayasinghe, Jingxian Liu, Yizhe Song, Song Cao, Andrew Houston, Xiuting Liu, Matthew A Wyczalkowski, Rita Jui-Hsien Lu, Wagma Caravan, Andrew Shinkle, Nataly Naser Al Deen, John M Herndon, Jacqueline Mudd, Cong Ma, Hirak Sarkar, Kazuhito Sato, Omar M Ibrahim, Chia-Kuei Mo, Sara E Chasnoff, Eduard Porta-Pardo, Jason M Held, Russell Pachynski, Julie K Schwarz, William E Gillanders, Albert H Kim, Ravi Vij, John F DiPersio, Sidharth V Puram, Milan G Chheda, Katherine C Fuh, David G DeNardo, Ryan C Fields, Feng Chen, Benjamin J Raphael, Li Ding", "Corresponding Author": "Ryan C Fields,Li Ding", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3655-5783,https://orcid.org/0000-0001-6176-8943,https://orcid.org/0000-0003-1517-2975", "Year of Publication": "2023", "Location of Publication": "Nature", "Publication Abstract": "Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis1,2,3,4. Although the genetic contributions to oncogenic transitions have been investigated, epigenetic drivers remain less understood. Here we constructed a pan-cancer epigenetic and transcriptomic atlas using single-nucleus chromatin accessibility data (using single-nucleus assay for transposase-accessible chromatin) from 225 samples and matched single-cell or single-nucleus RNA-sequencing expression data from 206 samples. With over 1\u2009million cells from each platform analysed through the enrichment of accessible chromatin regions, transcription factor motifs and regulons, we identified epigenetic drivers associated with cancer transitions. Some epigenetic drivers appeared in multiple cancers (for example, regulatory regions of ABCC1 and VEGFA; GATA6 and FOX-family motifs), whereas others were cancer specific (for example, regulatory regions of FGF19, ASAP2 and EN1, and the PBX3 motif). Among epigenetically altered pathways, TP53, hypoxia and TNF signalling were linked to cancer initiation, whereas oestrogen response, epithelial\u2013mesenchymal transition and apical junction were tied to metastatic transition. Furthermore, we revealed a marked correlation between enhancer accessibility and gene expression and uncovered cooperation between epigenetic and genetic drivers. This atlas provides a foundation for further investigation of epigenetic dynamics in cancer transitions.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/37914932/", "Publication contains HTAN ID": "", "Data Type": "10X Visium,Bulk DNA,Bulk RNA-seq,CODEX,H&E,IMC,scATAC-seq,scRNA-seq", "Tool": "Yes", "Supporting Link": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240822,https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE240699,https://github.com/ding-lab/somaticwrapper,https://github.com/ding-lab/10Xmapping,https://github.com/ding-lab/VirusScan/tree/simplified,https://github.com/ding-lab/COCOONS", "Supporting Link Description": "Matrices for CPTAC GBM and ccRCC samples are available from the Gene Expression Omnibus (GEO) under accession number GSE240822^^^CUT&RUN data are available from the Gene Expression Omnibus (GEO) under accession number GSE240699^^^Somaticwrapper variant calling pipeline^^^Code for the mutation mapping from bulk to single cells^^^Pipeline for HPV status assignment^^^COCOON", "Publication-associated HTAN Parent Data File ID": [ "HTA12_27_1007", "HTA12_27_1008", "HTA12_22_1005", "HTA12_22_1006", "HTA12_23_1003", "HTA12_23_1004", "HTA12_24_1007", "HTA12_24_1008", "HTA12_25_1005", "HTA12_25_1006", "HTA12_26_1007", "HTA12_26_1008", "HTA12_28_1007", "HTA12_28_1008", "HTA12_30_1003", "HTA12_30_1004", "HTA12_31_1003", "HTA12_31_1004", "HTA12_32_1001", "HTA12_32_1002", "HTA12_85_1040", "HTA12_85_1041", "HTA12_86_1040", "HTA12_86_1041", "HTA12_87_1040", "HTA12_87_1041", "HTA12_88_1040", "HTA12_88_1041", "HTA12_89_1040", "HTA12_89_1041", "HTA12_90_1040", "HTA12_90_1041", "HTA12_91_1040", "HTA12_91_1041", "HTA12_92_1040", "HTA12_92_1041", "HTA12_93_1040", "HTA12_93_1041", "HTA12_94_1040", "HTA12_94_1041", "HTA12_95_1040", "HTA12_95_1041", "HTA12_96_1040", "HTA12_96_1041", "HTA12_97_1040", "HTA12_97_1041", "HTA12_98_1040", "HTA12_98_1041", "HTA12_101_1040", "HTA12_101_1041", "HTA12_101_1042", "HTA12_101_1043", 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"HTA12_222_2020", "HTA12_EXT35_2000", "HTA12_EXT36_2000", "HTA12_EXT37_2000", "HTA12_188_2000", "HTA12_189_2000", "HTA12_190_2000", "HTA12_191_2000", "HTA12_192_2000", "HTA12_193_2000", "HTA12_194_2000", "HTA12_223_2000", "HTA12_224_2000", "HTA12_225_2000", "HTA12_226_2000", "HTA12_123_2000", "HTA12_149_2000", "HTA12_120_2000", "HTA12_120_2001", "HTA12_127_2000", "HTA12_127_2001", "HTA12_22_3001", "HTA12_22_3002", "HTA12_22_3003", "HTA12_23_3001", "HTA12_23_3002", "HTA12_23_3003", "HTA12_24_3001", "HTA12_24_3002", "HTA12_24_3003", "HTA12_25_3001", "HTA12_25_3002", "HTA12_25_3003", "HTA12_26_3001", "HTA12_26_3002", "HTA12_26_3003", "HTA12_27_3001", "HTA12_27_3002", "HTA12_27_3003", "HTA12_28_3001", "HTA12_28_3002", "HTA12_28_3003", "HTA12_30_3001", "HTA12_30_3002", "HTA12_30_3003", "HTA12_31_3001", "HTA12_31_3002", "HTA12_31_3003", "HTA12_32_3001", "HTA12_32_3002", "HTA12_32_3003", "HTA12_105_3000", "HTA12_105_3001", "HTA12_105_3002", "HTA12_118_3000", "HTA12_118_3001", "HTA12_118_3002", "HTA12_119_3000", "HTA12_119_3001", "HTA12_119_3002", "HTA12_120_3000", "HTA12_120_3001", "HTA12_120_3002", "HTA12_123_3000", "HTA12_123_3001", "HTA12_123_3002", "HTA12_124_3000", "HTA12_124_3001", "HTA12_124_3002", "HTA12_126_3000", "HTA12_126_3001", "HTA12_126_3002", "HTA12_127_3000", "HTA12_127_3001", "HTA12_127_3002", "HTA12_129_3000", "HTA12_129_3001", "HTA12_129_3002", "HTA12_130_3000", "HTA12_130_3001", "HTA12_130_3002", "HTA12_131_3000", "HTA12_131_3001", "HTA12_131_3002", "HTA12_EXT35_3000", "HTA12_EXT35_3001", "HTA12_EXT35_3002", "HTA12_EXT36_3000", "HTA12_EXT36_3001", "HTA12_EXT36_3002", "HTA12_EXT37_3000", "HTA12_EXT37_3001", "HTA12_EXT37_3002", "HTA12_106_3000", "HTA12_106_3001", "HTA12_106_3002", "HTA12_106_3003", "HTA12_106_3004", "HTA12_106_3005", "HTA12_108_3000", "HTA12_108_3001", "HTA12_108_3002", "HTA12_109_3000", "HTA12_109_3001", "HTA12_109_3002", "HTA12_111_3000", "HTA12_111_3001", "HTA12_111_3002", "HTA12_111_3003", "HTA12_111_3004", "HTA12_111_3005", "HTA12_112_3000", "HTA12_112_3001", "HTA12_112_3002", "HTA12_167_3000", "HTA12_167_3001", "HTA12_167_3002", "HTA12_188_3000", "HTA12_188_3001", "HTA12_188_3002", "HTA12_189_3000", "HTA12_189_3001", "HTA12_189_3002", "HTA12_190_3000", "HTA12_190_3001", "HTA12_190_3002", "HTA12_191_3000", "HTA12_191_3001", "HTA12_191_3002", "HTA12_192_3000", "HTA12_192_3001", "HTA12_192_3002", "HTA12_193_3000", "HTA12_193_3001", "HTA12_193_3002", "HTA12_194_3000", "HTA12_194_3001", "HTA12_194_3002", "HTA12_217_3000", "HTA12_217_3001", "HTA12_217_3002", "HTA12_223_3000", "HTA12_223_3001", "HTA12_223_3002", "HTA12_224_3000", "HTA12_224_3001", "HTA12_224_3002", "HTA12_225_3000", "HTA12_225_3001", "HTA12_225_3002", "HTA12_226_3000", "HTA12_226_3001", "HTA12_226_3002", "HTA12_120_3003", "HTA12_120_3004", "HTA12_120_3005", "HTA12_120_3006", "HTA12_120_3007", "HTA12_120_3008", "HTA12_127_3006", "HTA12_127_3007", "HTA12_127_3008", "HTA12_23_2002", "HTA12_30_2002", "HTA12_31_2002", "HTA12_129_2000", "HTA12_129_2001", "HTA12_129_2002", "HTA12_134_2000", "HTA12_134_2001", "HTA12_134_2002", "HTA12_134_2003", "HTA12_135_2000", "HTA12_135_2001", "HTA12_135_2002", "HTA12_135_2003", "HTA12_135_2004", "HTA12_135_2005", "HTA12_139_2000", "HTA12_140_2002", "HTA12_140_2003", "HTA12_140_2001", "HTA12_140_2004", "HTA12_140_2000", "HTA12_142_2000", "HTA12_142_2001", "HTA12_142_2002", "HTA12_142_2003", "HTA12_144_2000", "HTA12_145_2000", "HTA12_22_3004", "HTA12_22_3005", "HTA12_22_3006", "HTA12_22_3009", "HTA12_23_3004", "HTA12_23_3005", "HTA12_23_3006", "HTA12_23_3009", "HTA12_25_3004", "HTA12_25_3005", "HTA12_25_3006", "HTA12_25_3009", "HTA12_25_3010", "HTA12_25_3011", "HTA12_25_3012", "HTA12_25_3015", "HTA12_25_3016", "HTA12_25_3017", "HTA12_25_3018", "HTA12_25_3021", "HTA12_25_3022", "HTA12_25_3023", "HTA12_25_3024", "HTA12_25_3027", "HTA12_30_3004", "HTA12_30_3005", "HTA12_30_3006", "HTA12_30_3009", "HTA12_31_3004", "HTA12_31_3005", "HTA12_31_3006", "HTA12_31_3009", "HTA12_135_3009", "HTA12_135_3027", "HTA12_135_3035", "HTA12_135_3002", "HTA12_135_3037", "HTA12_135_3005", "HTA12_135_3010", "HTA12_135_3028", "HTA12_135_3038", "HTA12_135_3036", "HTA12_135_3034", "HTA12_135_3004", "HTA12_135_3011", "HTA12_135_3029", "HTA12_135_3003", "HTA12_135_3015", "HTA12_135_3019", "HTA12_135_3039", "HTA12_135_3012", "HTA12_135_3030", "HTA12_135_3006", "HTA12_135_3033", "HTA12_135_3007", "HTA12_135_3017", "HTA12_135_3013", "HTA12_135_3031", "HTA12_135_3025", "HTA12_135_3018", "HTA12_135_3000", "HTA12_135_3016", "HTA12_135_3014", "HTA12_135_3032", "HTA12_135_3008", "HTA12_135_3001", "HTA12_135_3026", "HTA12_135_3024", "HTA12_142_3007", "HTA12_142_3014", "HTA12_142_3027", "HTA12_142_3011", "HTA12_142_3017", "HTA12_142_3002", "HTA12_142_3008", "HTA12_142_3015", "HTA12_142_3003", "HTA12_142_3012", "HTA12_142_3018", "HTA12_142_3005", "HTA12_142_3009", "HTA12_142_3016", "HTA12_142_3010", "HTA12_142_3000", "HTA12_142_3004", "HTA12_142_3026", "HTA12_22_3007", "HTA12_22_3008", "HTA12_23_3007", "HTA12_23_3008", "HTA12_25_3007", "HTA12_25_3008", "HTA12_25_3013", "HTA12_25_3014", "HTA12_25_3019", "HTA12_25_3020", "HTA12_25_3025", "HTA12_25_3026", "HTA12_30_3007", "HTA12_30_3008", "HTA12_31_3007", "HTA12_31_3008", "HTA12_129_1008", "HTA12_129_1009", "HTA12_129_1014", "HTA12_134_1016", "HTA12_134_1017", "HTA12_135_1030", "HTA12_135_1031", "HTA12_142_1014", "HTA12_135_1026", "HTA12_140_1015", "HTA12_142_1015", "HTA12_135_1027", "HTA12_140_1016", "HTA12_134_1014", "HTA12_142_1016", "HTA12_144_1002", "HTA12_135_1028", "HTA12_140_1017", "HTA12_134_1015", "HTA12_139_1004", "HTA12_140_1014", "HTA12_142_1017", "HTA12_145_1004", "HTA12_135_1029", "HTA12_140_1018", "HTA12_EXT35_1023", "HTA12_EXT35_1020", "HTA12_EXT35_1021", "HTA12_EXT35_1022", "HTA12_EXT36_1023", "HTA12_EXT36_1020", "HTA12_EXT36_1021", "HTA12_EXT36_1022", "HTA12_EXT37_1023", "HTA12_EXT37_1021", "HTA12_EXT37_1022", "HTA12_EXT37_1020", "HTA12_81_1020", "HTA12_81_1021", "HTA12_81_1022", "HTA12_81_1023", "HTA12_82_1020", "HTA12_82_1021", "HTA12_82_1022", "HTA12_83_1020", "HTA12_83_1021", "HTA12_83_1022", "HTA12_83_1023", "HTA12_83_1024", "HTA12_83_1025", "HTA12_84_1020", "HTA12_84_1021", "HTA12_84_1022", "HTA12_84_1023", "HTA12_84_1024", "HTA12_84_1025", "HTA12_85_1020", "HTA12_85_1021", "HTA12_85_1022", "HTA12_86_1020", "HTA12_86_1021", "HTA12_86_1022", "HTA12_87_1020", "HTA12_87_1021", "HTA12_87_1022", "HTA12_88_1020", "HTA12_88_1021", "HTA12_88_1022", "HTA12_89_1020", "HTA12_89_1021", "HTA12_89_1022", "HTA12_90_1020", "HTA12_90_1021", "HTA12_90_1022", "HTA12_91_1020", "HTA12_91_1021", "HTA12_91_1022", "HTA12_92_1020", "HTA12_92_1021", "HTA12_92_1022", "HTA12_92_1023", "HTA12_92_1024", "HTA12_92_1025", "HTA12_93_1020", "HTA12_93_1021", "HTA12_93_1022", "HTA12_94_1020", "HTA12_94_1021", "HTA12_94_1022", "HTA12_95_1020", "HTA12_95_1021", "HTA12_95_1022", "HTA12_96_1020", "HTA12_96_1021", "HTA12_96_1022", "HTA12_97_1020", "HTA12_97_1021", "HTA12_97_1022", "HTA12_98_1020", "HTA12_98_1021", "HTA12_98_1022", "HTA12_99_1020", "HTA12_99_1021", "HTA12_99_1022", "HTA12_100_1020", "HTA12_100_1021", "HTA12_100_1022", "HTA12_113_1020", "HTA12_113_1021", "HTA12_113_1022", "HTA12_113_1023", "HTA12_113_1024", "HTA12_113_1025", "HTA12_114_1020", "HTA12_114_1021", "HTA12_114_1022", "HTA12_158_1020", "HTA12_158_1021", "HTA12_158_1022", "HTA12_188_1023", "HTA12_188_1020", "HTA12_188_1021", "HTA12_188_1022", "HTA12_189_1023", "HTA12_189_1020", "HTA12_189_1021", "HTA12_189_1022", "HTA12_190_1023", "HTA12_190_1020", "HTA12_190_1021", "HTA12_190_1022", "HTA12_191_1023", "HTA12_191_1020", "HTA12_191_1021", "HTA12_191_1022", "HTA12_192_1023", "HTA12_192_1020", "HTA12_192_1021", "HTA12_192_1022", "HTA12_193_1023", "HTA12_193_1020", "HTA12_193_1021", "HTA12_193_1022", "HTA12_194_1023", "HTA12_194_1020", "HTA12_194_1021", "HTA12_194_1022", "HTA12_76_1020", "HTA12_76_1021", "HTA12_76_1022", "HTA12_76_1023", "HTA12_76_1024", "HTA12_76_1025", "HTA12_77_1020", "HTA12_77_1021", "HTA12_77_1022", "HTA12_77_1023", "HTA12_77_1024", "HTA12_77_1025", "HTA12_223_1023", "HTA12_223_1020", "HTA12_223_1021", "HTA12_223_1022", "HTA12_224_1023", "HTA12_224_1020", "HTA12_224_1021", "HTA12_224_1022", "HTA12_225_1023", "HTA12_225_1020", "HTA12_225_1021", "HTA12_225_1022", "HTA12_226_1023", "HTA12_226_1020", "HTA12_226_1021", "HTA12_226_1022", "HTA12_101_1020", "HTA12_101_1021", "HTA12_101_1022", "HTA12_101_1023", "HTA12_101_1024", "HTA12_101_1025", "HTA12_102_1020", "HTA12_102_1021", "HTA12_102_1022", "HTA12_102_1023", "HTA12_102_1024", "HTA12_102_1025", "HTA12_103_1020", "HTA12_103_1021", "HTA12_103_1022", "HTA12_103_1023", "HTA12_103_1024", "HTA12_103_1025", "HTA12_104_1020", "HTA12_104_1021", "HTA12_104_1022", "HTA12_104_1023", "HTA12_104_1024", "HTA12_104_1025", "HTA12_105_1020", "HTA12_105_1021", "HTA12_105_1022", "HTA12_105_1023", "HTA12_106_1020", "HTA12_106_1021", "HTA12_106_1022", "HTA12_106_1023", "HTA12_106_1024", "HTA12_106_1025", "HTA12_106_1026", "HTA12_106_1027", "HTA12_107_1020", "HTA12_107_1021", "HTA12_107_1022", "HTA12_107_1023", "HTA12_107_1024", "HTA12_107_1025", "HTA12_107_1026", "HTA12_107_1027", "HTA12_107_1028", "HTA12_107_1029", "HTA12_107_1030", "HTA12_107_1031", "HTA12_108_1020", "HTA12_108_1021", "HTA12_108_1022", "HTA12_108_1023", "HTA12_108_1024", "HTA12_108_1025", "HTA12_109_1020", "HTA12_109_1021", "HTA12_109_1022", "HTA12_109_1023", "HTA12_109_1024", "HTA12_109_1025", "HTA12_110_1020", "HTA12_110_1021", "HTA12_110_1022", "HTA12_110_1023", "HTA12_110_1024", "HTA12_110_1025", "HTA12_110_1026", "HTA12_110_1027", "HTA12_111_1020", "HTA12_111_1021", "HTA12_111_1022", "HTA12_111_1023", "HTA12_111_1024", "HTA12_111_1025", "HTA12_111_1026", "HTA12_111_1027", "HTA12_112_1020", "HTA12_112_1021", "HTA12_112_1022", "HTA12_112_1023", "HTA12_112_1024", "HTA12_112_1025", "HTA12_112_1026", "HTA12_112_1027", "HTA12_112_1028", "HTA12_115_1020", "HTA12_115_1021", "HTA12_115_1022", "HTA12_115_1023", "HTA12_115_1024", "HTA12_115_1025", "HTA12_116_1020", "HTA12_116_1021", "HTA12_116_1022", "HTA12_117_1020", "HTA12_117_1021", "HTA12_117_1022", "HTA12_117_1023", "HTA12_117_1024", "HTA12_117_1025", "HTA12_117_1026", "HTA12_117_1027", "HTA12_118_1020", "HTA12_118_1021", "HTA12_118_1022", "HTA12_118_1023", "HTA12_119_1020", "HTA12_119_1021", "HTA12_119_1022", "HTA12_119_1023", "HTA12_120_1020", "HTA12_120_1021", "HTA12_120_1022", "HTA12_120_1023", "HTA12_120_1024", "HTA12_120_1025", "HTA12_120_1026", "HTA12_120_1027", "HTA12_121_1020", "HTA12_121_1021", "HTA12_121_1022", "HTA12_122_1020", "HTA12_122_1021", "HTA12_122_1022", "HTA12_123_1020", "HTA12_123_1021", "HTA12_123_1022", "HTA12_123_1023", "HTA12_124_1020", "HTA12_124_1021", "HTA12_124_1022", "HTA12_124_1023", "HTA12_125_1020", "HTA12_125_1021", "HTA12_125_1022", "HTA12_125_1023", "HTA12_125_1024", "HTA12_125_1025", "HTA12_125_1026", "HTA12_125_1027", "HTA12_126_1020", "HTA12_126_1021", "HTA12_126_1022", "HTA12_126_1023", "HTA12_127_1020", "HTA12_127_1021", "HTA12_127_1022", "HTA12_127_1023", "HTA12_128_1020", "HTA12_128_1021", "HTA12_128_1022", "HTA12_129_1020", "HTA12_129_1021", "HTA12_129_1022", "HTA12_129_1023", "HTA12_130_1020", "HTA12_130_1021", "HTA12_130_1022", "HTA12_130_1023", "HTA12_131_1020", "HTA12_131_1021", "HTA12_131_1022", "HTA12_131_1023", "HTA12_22_1020", "HTA12_22_1021", "HTA12_22_1022", "HTA12_132_1020", "HTA12_132_1021", "HTA12_132_1022", "HTA12_133_1020", "HTA12_133_1021", "HTA12_133_1022", "HTA12_23_1020", "HTA12_23_1021", "HTA12_23_1022", "HTA12_24_1020", "HTA12_24_1021", "HTA12_24_1022", "HTA12_134_1020", "HTA12_134_1021", "HTA12_134_1022", "HTA12_134_1023", "HTA12_134_1024", "HTA12_134_1025", "HTA12_25_1021", "HTA12_25_1022", "HTA12_25_1023", "HTA12_25_1024", "HTA12_25_1025", "HTA12_25_1026", "HTA12_135_1020", "HTA12_135_1021", "HTA12_135_1022", "HTA12_135_1023", "HTA12_135_1024", "HTA12_135_1025", "HTA12_136_1020", "HTA12_136_1021", "HTA12_136_1022", "HTA12_137_1020", "HTA12_137_1021", "HTA12_137_1022", "HTA12_26_1020", "HTA12_26_1021", "HTA12_26_1022", "HTA12_138_1020", "HTA12_138_1021", "HTA12_138_1022", "HTA12_139_1020", "HTA12_139_1021", "HTA12_139_1022", "HTA12_27_1020", "HTA12_27_1021", "HTA12_27_1022", "HTA12_27_1023", "HTA12_27_1024", "HTA12_27_1025", "HTA12_140_1020", "HTA12_140_1021", "HTA12_140_1022", "HTA12_28_1020", "HTA12_28_1021", "HTA12_28_1022", "HTA12_28_1023", "HTA12_28_1024", "HTA12_28_1025", "HTA12_28_1026", "HTA12_28_1027", "HTA12_28_1028", "HTA12_142_1020", "HTA12_142_1021", "HTA12_142_1022", "HTA12_30_1020", "HTA12_30_1021", "HTA12_30_1022", "HTA12_143_1020", "HTA12_143_1021", "HTA12_143_1022", "HTA12_144_1020", "HTA12_144_1021", "HTA12_144_1022", "HTA12_145_1020", "HTA12_145_1021", "HTA12_145_1022", "HTA12_31_1020", "HTA12_31_1021", "HTA12_31_1022", "HTA12_146_1020", "HTA12_146_1021", "HTA12_146_1022", "HTA12_147_1020", "HTA12_147_1021", "HTA12_147_1022", "HTA12_148_1020", "HTA12_148_1021", "HTA12_148_1022", "HTA12_148_1023", "HTA12_148_1024", "HTA12_148_1025", "HTA12_149_1020", "HTA12_149_1021", "HTA12_149_1022", "HTA12_150_1020", "HTA12_150_1021", "HTA12_150_1022", "HTA12_32_1020", "HTA12_32_1021", "HTA12_32_1022", "HTA12_32_1023", "HTA12_32_1024", "HTA12_32_1025", "HTA12_151_1020", "HTA12_151_1021", "HTA12_151_1022", "HTA12_152_1020", "HTA12_152_1021", "HTA12_152_1022", "HTA12_153_1020", "HTA12_153_1021", "HTA12_153_1022", "HTA12_154_1020", "HTA12_154_1021", "HTA12_154_1022", "HTA12_155_1020", "HTA12_155_1021", "HTA12_155_1022", "HTA12_156_1020", "HTA12_156_1021", "HTA12_156_1022", "HTA12_157_1020", "HTA12_157_1021", "HTA12_157_1022", "HTA12_159_1020", "HTA12_159_1021", "HTA12_159_1022", "HTA12_160_1020", "HTA12_160_1021", "HTA12_160_1022", "HTA12_161_1020", "HTA12_161_1021", "HTA12_161_1022", "HTA12_162_1020", "HTA12_162_1021", "HTA12_162_1022", "HTA12_163_1020", "HTA12_163_1021", "HTA12_163_1022", "HTA12_164_1020", "HTA12_164_1021", "HTA12_164_1022", "HTA12_165_1020", "HTA12_165_1021", "HTA12_165_1022", "HTA12_166_1020", "HTA12_166_1021", "HTA12_166_1022", "HTA12_167_1020", "HTA12_167_1021", "HTA12_167_1022", "HTA12_167_1023", "HTA12_168_1020", "HTA12_168_1021", "HTA12_168_1022", "HTA12_169_1020", "HTA12_169_1021", "HTA12_169_1022", "HTA12_169_1023", "HTA12_169_1024", "HTA12_169_1025", "HTA12_169_1026", "HTA12_169_1027", "HTA12_169_1028", "HTA12_169_1029", "HTA12_169_1030", "HTA12_169_1031", "HTA12_170_1020", "HTA12_170_1021", "HTA12_170_1022", "HTA12_171_1020", "HTA12_171_1021", "HTA12_171_1022", "HTA12_171_1023", "HTA12_171_1024", "HTA12_171_1025", "HTA12_172_1020", "HTA12_172_1021", "HTA12_172_1022", "HTA12_173_1020", "HTA12_173_1021", "HTA12_173_1022", "HTA12_174_1020", "HTA12_174_1021", "HTA12_174_1022", "HTA12_175_1020", "HTA12_175_1021", "HTA12_175_1022", "HTA12_176_1020", "HTA12_176_1021", "HTA12_176_1022", "HTA12_177_1020", "HTA12_177_1021", "HTA12_177_1022", "HTA12_178_1020", "HTA12_178_1021", "HTA12_178_1022", "HTA12_179_1020", 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"HTA12_102_2011", "HTA12_103_2010", "HTA12_103_2011", "HTA12_104_2010", "HTA12_104_2011", "HTA12_105_2010", "HTA12_106_2010", "HTA12_106_2011", "HTA12_107_2010", "HTA12_107_2011", "HTA12_108_2010", "HTA12_108_2011", "HTA12_109_2010", "HTA12_109_2011", "HTA12_110_2010", "HTA12_110_2011", "HTA12_111_2010", "HTA12_111_2011", "HTA12_112_2010", "HTA12_112_2011", "HTA12_112_2012", "HTA12_113_2010", "HTA12_114_2010", "HTA12_115_2010", "HTA12_116_2010", "HTA12_117_2010", "HTA12_118_2010", "HTA12_119_2010", "HTA12_120_2010", "HTA12_120_2011", "HTA12_121_2010", "HTA12_122_2010", "HTA12_123_2010", "HTA12_124_2010", "HTA12_125_2010", "HTA12_126_2010", "HTA12_127_2010", "HTA12_128_2010", "HTA12_129_2010", "HTA12_130_2010", "HTA12_131_2010", "HTA12_22_2010", "HTA12_132_2010", "HTA12_133_2010", "HTA12_23_2010", "HTA12_24_2010", "HTA12_134_2010", "HTA12_25_2010", "HTA12_135_2010", "HTA12_136_2010", "HTA12_137_2010", "HTA12_26_2010", "HTA12_138_2010", "HTA12_139_2010", "HTA12_27_2010", 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"HTA12_189_2010", "HTA12_190_2010", "HTA12_191_2010", "HTA12_192_2010", "HTA12_193_2010", "HTA12_194_2010", "HTA12_195_2010", "HTA12_195_2011", "HTA12_196_2010", "HTA12_196_2011", "HTA12_197_2010", "HTA12_198_2010", "HTA12_199_2010", "HTA12_200_2010", "HTA12_201_2010", "HTA12_202_2010", "HTA12_203_2010", "HTA12_204_2010", "HTA12_205_2010", "HTA12_206_2010", "HTA12_207_2010", "HTA12_208_2010", "HTA12_209_2010", "HTA12_210_2010", "HTA12_211_2010", "HTA12_212_2010", "HTA12_EXT213_2010", "HTA12_76_2010", "HTA12_77_2010", "HTA12_214_2010", "HTA12_215_2010", "HTA12_215_2011", "HTA12_216_2010", "HTA12_217_2010", "HTA12_218_2010", "HTA12_219_2010", "HTA12_220_2010", "HTA12_221_2010", "HTA12_222_2010", "HTA12_223_2010", "HTA12_224_2010", "HTA12_225_2010", "HTA12_226_2010", "HTA12_149_2001", "HTA12_105_3010", "HTA12_105_3013", "HTA12_105_3012", "HTA12_105_3011", "HTA12_115_3010", "HTA12_115_3013", "HTA12_115_3012", "HTA12_115_3011", "HTA12_116_3010", "HTA12_116_3013", "HTA12_116_3012", 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"HTA12_26_3023", "HTA12_138_3020", "HTA12_138_3021", "HTA12_138_3022", "HTA12_138_3023", "HTA12_139_3020", "HTA12_139_3021", "HTA12_139_3022", "HTA12_139_3023", "HTA12_27_3020", "HTA12_27_3021", "HTA12_27_3022", "HTA12_27_3023", "HTA12_140_3020", "HTA12_140_3021", "HTA12_140_3022", "HTA12_140_3023", "HTA12_28_3020", "HTA12_28_3022", "HTA12_28_3024", "HTA12_28_3026", "HTA12_28_3021", "HTA12_28_3023", "HTA12_28_3025", "HTA12_28_3027", "HTA12_142_3020", "HTA12_142_3021", "HTA12_142_3022", "HTA12_142_3023", "HTA12_30_3020", "HTA12_30_3021", "HTA12_30_3022", "HTA12_30_3023", "HTA12_143_3020", "HTA12_143_3021", "HTA12_143_3022", "HTA12_143_3023", "HTA12_144_3020", "HTA12_144_3021", "HTA12_144_3022", "HTA12_144_3023", "HTA12_145_3020", "HTA12_145_3021", "HTA12_145_3022", "HTA12_145_3023", "HTA12_31_3020", "HTA12_31_3021", "HTA12_31_3022", "HTA12_31_3023", "HTA12_146_3020", "HTA12_146_3021", "HTA12_146_3022", "HTA12_146_3023", "HTA12_147_3020", "HTA12_147_3021", "HTA12_147_3022", "HTA12_147_3023", "HTA12_148_3020", "HTA12_148_3021", "HTA12_148_3022", "HTA12_148_3023", "HTA12_148_3024", "HTA12_148_3025", "HTA12_148_3026", "HTA12_148_3027", "HTA12_149_3020", "HTA12_149_3021", "HTA12_149_3022", "HTA12_149_3023", "HTA12_150_3020", "HTA12_150_3021", "HTA12_150_3022", "HTA12_150_3023", "HTA12_32_3020", "HTA12_32_3021", "HTA12_32_3022", "HTA12_32_3023", "HTA12_151_3020", "HTA12_151_3021", "HTA12_151_3022", "HTA12_151_3023", "HTA12_152_3020", "HTA12_152_3021", "HTA12_152_3022", "HTA12_152_3023", "HTA12_153_3020", "HTA12_153_3021", "HTA12_153_3022", "HTA12_153_3023", "HTA12_154_3020", "HTA12_154_3021", "HTA12_154_3022", "HTA12_154_3023", "HTA12_155_3020", "HTA12_155_3021", "HTA12_155_3022", "HTA12_155_3023", "HTA12_156_3020", "HTA12_156_3021", "HTA12_156_3022", "HTA12_156_3023", "HTA12_85_3020", "HTA12_85_3021", "HTA12_85_3022", "HTA12_85_3023", "HTA12_86_3020", "HTA12_86_3021", "HTA12_86_3022", "HTA12_86_3023", "HTA12_87_3020", "HTA12_87_3021", "HTA12_87_3022", "HTA12_87_3023", "HTA12_88_3020", "HTA12_88_3021", "HTA12_88_3022", "HTA12_88_3023", "HTA12_89_3020", "HTA12_89_3021", "HTA12_89_3022", "HTA12_89_3023", "HTA12_90_3020", "HTA12_90_3021", "HTA12_90_3022", "HTA12_90_3023", "HTA12_91_3020", "HTA12_91_3021", "HTA12_91_3022", "HTA12_91_3023", "HTA12_92_3020", "HTA12_92_3021", "HTA12_92_3022", "HTA12_92_3023", "HTA12_93_3020", "HTA12_93_3021", "HTA12_93_3022", "HTA12_93_3023", "HTA12_94_3020", "HTA12_94_3021", "HTA12_94_3022", "HTA12_94_3023", "HTA12_95_3020", "HTA12_95_3021", "HTA12_95_3022", "HTA12_95_3023", "HTA12_96_3020", "HTA12_96_3021", "HTA12_96_3022", "HTA12_96_3023", "HTA12_97_3020", "HTA12_97_3021", "HTA12_97_3022", "HTA12_97_3023", "HTA12_98_3020", "HTA12_98_3021", "HTA12_98_3022", "HTA12_98_3023", "HTA12_107_3020", "HTA12_107_3021", "HTA12_107_3022", "HTA12_107_3023", "HTA12_108_3020", "HTA12_108_3021", "HTA12_108_3022", "HTA12_108_3023", "HTA12_109_3020", "HTA12_109_3021", "HTA12_109_3022", "HTA12_109_3023", "HTA12_112_3020", "HTA12_112_3021", "HTA12_112_3022", "HTA12_112_3023", "HTA12_112_3024", "HTA12_112_3025", "HTA12_112_3026", "HTA12_112_3027", "HTA12_113_3020", "HTA12_113_3021", "HTA12_113_3022", "HTA12_113_3023", "HTA12_114_3020", "HTA12_114_3021", "HTA12_114_3022", "HTA12_114_3023", "HTA12_158_3020", "HTA12_158_3021", "HTA12_158_3022", "HTA12_158_3023", "HTA12_159_3020", "HTA12_159_3021", "HTA12_159_3022", "HTA12_159_3023", "HTA12_160_3020", "HTA12_160_3021", "HTA12_160_3022", "HTA12_160_3023", "HTA12_161_3020", "HTA12_161_3021", "HTA12_161_3022", "HTA12_161_3023", "HTA12_162_3020", "HTA12_162_3021", "HTA12_162_3022", "HTA12_162_3023", "HTA12_163_3020", "HTA12_163_3021", "HTA12_163_3022", "HTA12_163_3023", "HTA12_164_3020", "HTA12_164_3021", "HTA12_164_3022", "HTA12_164_3023", "HTA12_165_3020", "HTA12_165_3021", "HTA12_165_3022", "HTA12_165_3023", "HTA12_166_3020", "HTA12_166_3021", "HTA12_166_3022", "HTA12_166_3023", "HTA12_168_3020", "HTA12_168_3021", "HTA12_168_3022", "HTA12_168_3023", "HTA12_169_3020", "HTA12_169_3021", "HTA12_169_3022", "HTA12_169_3023", "HTA12_169_3024", "HTA12_169_3025", "HTA12_169_3026", "HTA12_169_3027", "HTA12_170_3020", "HTA12_170_3021", "HTA12_170_3022", "HTA12_170_3023", "HTA12_171_3020", "HTA12_171_3021", "HTA12_171_3022", "HTA12_171_3023", "HTA12_172_3020", "HTA12_172_3021", "HTA12_172_3022", "HTA12_172_3023", "HTA12_173_3020", "HTA12_173_3021", "HTA12_173_3022", "HTA12_173_3023", "HTA12_174_3020", "HTA12_174_3021", "HTA12_174_3022", "HTA12_174_3023", "HTA12_175_3020", "HTA12_175_3021", "HTA12_175_3022", "HTA12_175_3023", "HTA12_176_3020", "HTA12_176_3021", "HTA12_176_3022", "HTA12_176_3023", "HTA12_177_3020", "HTA12_177_3021", "HTA12_177_3022", "HTA12_177_3023", "HTA12_178_3020", "HTA12_178_3021", "HTA12_178_3022", "HTA12_178_3023", "HTA12_179_3020", "HTA12_179_3021", "HTA12_179_3022", "HTA12_179_3023", "HTA12_180_3020", "HTA12_180_3021", "HTA12_180_3022", "HTA12_180_3023", "HTA12_181_3020", "HTA12_181_3021", "HTA12_181_3022", "HTA12_181_3023", "HTA12_182_3020", "HTA12_182_3021", "HTA12_182_3022", "HTA12_182_3023", "HTA12_183_3020", "HTA12_183_3021", "HTA12_183_3022", "HTA12_183_3023", "HTA12_184_3020", "HTA12_184_3021", "HTA12_184_3022", "HTA12_184_3023", "HTA12_185_3020", "HTA12_185_3021", "HTA12_185_3022", "HTA12_185_3023", "HTA12_186_3020", "HTA12_186_3021", "HTA12_186_3022", "HTA12_186_3023", "HTA12_187_3020", "HTA12_187_3021", "HTA12_187_3022", "HTA12_187_3023", "HTA12_195_3020", "HTA12_195_3022", "HTA12_195_3024", "HTA12_195_3026", "HTA12_195_3021", "HTA12_195_3023", "HTA12_195_3025", "HTA12_195_3027", "HTA12_196_3020", "HTA12_196_3022", "HTA12_196_3024", "HTA12_196_3026", "HTA12_196_3021", "HTA12_196_3023", "HTA12_196_3025", "HTA12_196_3027", "HTA12_197_3020", "HTA12_197_3021", "HTA12_197_3022", "HTA12_197_3023", "HTA12_198_3020", "HTA12_198_3021", "HTA12_198_3022", "HTA12_198_3023", "HTA12_199_3020", "HTA12_199_3021", "HTA12_199_3022", "HTA12_199_3023", "HTA12_200_3020", "HTA12_200_3021", "HTA12_200_3022", "HTA12_200_3023", "HTA12_201_3020", "HTA12_201_3021", "HTA12_201_3022", "HTA12_201_3023", "HTA12_202_3020", "HTA12_202_3021", "HTA12_202_3022", "HTA12_202_3023", "HTA12_203_3020", "HTA12_203_3021", "HTA12_203_3022", "HTA12_203_3023", "HTA12_204_3020", "HTA12_204_3021", "HTA12_204_3022", "HTA12_204_3023", "HTA12_205_3020", "HTA12_205_3021", "HTA12_205_3022", "HTA12_205_3023", "HTA12_206_3020", "HTA12_206_3021", "HTA12_206_3022", "HTA12_206_3023", "HTA12_207_3020", "HTA12_207_3021", "HTA12_207_3022", "HTA12_207_3023", "HTA12_208_3020", "HTA12_208_3021", "HTA12_208_3022", "HTA12_208_3023", "HTA12_209_3020", "HTA12_209_3021", "HTA12_209_3022", "HTA12_209_3023", "HTA12_210_3020", "HTA12_210_3021", "HTA12_210_3022", "HTA12_210_3023", "HTA12_211_3020", "HTA12_211_3021", "HTA12_211_3022", "HTA12_211_3023", "HTA12_212_3020", "HTA12_212_3021", "HTA12_212_3022", "HTA12_212_3023", "HTA12_EXT213_3020", "HTA12_EXT213_3021", "HTA12_EXT213_3022", "HTA12_EXT213_3023", "HTA12_76_3020", "HTA12_76_3021", "HTA12_76_3022", "HTA12_76_3023", "HTA12_77_3020", "HTA12_77_3021", "HTA12_77_3022", "HTA12_77_3023", "HTA12_214_3020", "HTA12_214_3021", "HTA12_214_3022", "HTA12_214_3023", "HTA12_215_3020", "HTA12_215_3022", "HTA12_215_3024", "HTA12_215_3026", "HTA12_215_3021", "HTA12_215_3023", "HTA12_215_3025", "HTA12_215_3027", "HTA12_218_3020", "HTA12_218_3021", "HTA12_218_3022", "HTA12_218_3023", "HTA12_219_3020", "HTA12_219_3021", "HTA12_219_3022", "HTA12_219_3023", "HTA12_220_3020", "HTA12_220_3021", "HTA12_220_3022", "HTA12_220_3023", "HTA12_221_3020", "HTA12_221_3021", "HTA12_221_3022", "HTA12_221_3023", "HTA12_222_3020", "HTA12_222_3021", "HTA12_222_3022", "HTA12_222_3023", "HTA12_118_4001", "HTA12_119_4001", "HTA12_120_4003", "HTA12_120_4004", "HTA12_123_4002", "HTA12_124_4001", "HTA12_125_4000", "HTA12_126_4001", "HTA12_127_4003", "HTA12_129_4001", "HTA12_130_4001", "HTA12_131_4001", "HTA12_134_4001", "HTA12_135_4001", "HTA12_139_4001", "HTA12_142_4001", "HTA12_144_4001", "HTA12_145_4001", "HTA12_118_4002", "HTA12_119_4002", "HTA12_120_4012", "HTA12_120_4011", "HTA12_123_4011", "HTA12_124_4011", "HTA12_125_4001", "HTA12_126_4011", "HTA12_127_4011", "HTA12_129_4011", "HTA12_130_4011", "HTA12_131_4011", "HTA12_134_4011", "HTA12_135_4011", "HTA12_139_4011", "HTA12_140_4000", "HTA12_142_4011", "HTA12_144_4011", "HTA12_145_4011", "HTA12_148_4000", "HTA12_148_4001", "HTA12_149_4011", "HTA12_153_4000", "HTA12_154_4000", "HTA12_155_4000", "HTA12_156_4000", "HTA12_81_4000", "HTA12_82_4000", "HTA12_83_4000", "HTA12_84_4000", "HTA12_85_4000", "HTA12_86_4000", "HTA12_87_4000", "HTA12_88_4000", "HTA12_89_4000", "HTA12_90_4000", "HTA12_91_4000", "HTA12_92_4000", "HTA12_93_4000", "HTA12_94_4000", "HTA12_95_4000", "HTA12_96_4000", "HTA12_97_4000", "HTA12_98_4000", "HTA12_99_4000", "HTA12_100_4000", "HTA12_101_4000", "HTA12_101_4001", "HTA12_102_4000", "HTA12_102_4001", "HTA12_103_4000", "HTA12_103_4001", "HTA12_104_4000", "HTA12_104_4001", "HTA12_105_4000", "HTA12_106_4000", "HTA12_106_4001", "HTA12_107_4000", "HTA12_107_4001", "HTA12_132_4000", "HTA12_133_4000", "HTA12_136_4000", "HTA12_137_4000", "HTA12_138_4000", "HTA12_143_4000", "HTA12_146_4000", "HTA12_76_4000", "HTA12_77_4000", "HTA12_113_4000", "HTA12_114_4000", "HTA12_157_4000", "HTA12_158_4000", "HTA12_159_4000", "HTA12_160_4000", "HTA12_161_4000", "HTA12_162_4000", "HTA12_163_4000", "HTA12_164_4000", "HTA12_165_4000", "HTA12_166_4000", "HTA12_195_4000", "HTA12_195_4001", "HTA12_196_4000", "HTA12_196_4001", "HTA12_197_4000", "HTA12_198_4000", "HTA12_199_4000", "HTA12_200_4000", "HTA12_201_4000", "HTA12_202_4000", "HTA12_203_4000", "HTA12_204_4000", "HTA12_205_4000", "HTA12_EXT35_4000", "HTA12_EXT36_4000", "HTA12_EXT37_4000", "HTA12_188_4000", "HTA12_189_4000", "HTA12_190_4000", "HTA12_191_4000", "HTA12_192_4000", "HTA12_193_4000", "HTA12_194_4000", "HTA12_223_4000", "HTA12_224_4000", "HTA12_225_4000", "HTA12_226_4000", "HTA12_214_4000", "HTA12_215_4001", "HTA12_215_4000", "HTA12_216_4000", "HTA12_217_4000", "HTA12_218_4000", "HTA12_219_4000", "HTA12_220_4000", "HTA12_221_4000", "HTA12_222_4000", "HTA12_115_4000", "HTA12_116_4000", "HTA12_117_4000", "HTA12_121_4000", "HTA12_122_4000", "HTA12_128_4000", "HTA12_22_4000", "HTA12_23_4000", "HTA12_24_4000", "HTA12_25_4000", "HTA12_26_4000", "HTA12_27_4000", "HTA12_28_4000", "HTA12_28_4001", "HTA12_30_4000", "HTA12_31_4000", "HTA12_147_4000", "HTA12_150_4000", "HTA12_32_4000", "HTA12_151_4000", "HTA12_152_4000", "HTA12_206_4000", "HTA12_207_4000", "HTA12_208_4000", "HTA12_209_4000", "HTA12_210_4000", "HTA12_211_4000", "HTA12_212_4000", "HTA12_168_4000", "HTA12_169_4000", "HTA12_169_4001", "HTA12_170_4000", "HTA12_171_4000", "HTA12_172_4000", "HTA12_173_4000", "HTA12_174_4000", "HTA12_175_4000", "HTA12_176_4000", "HTA12_177_4000", "HTA12_178_4000", "HTA12_179_4000", "HTA12_180_4000", "HTA12_181_4000", "HTA12_182_4000", "HTA12_183_4000", "HTA12_184_4000", "HTA12_185_4000", "HTA12_186_4000", "HTA12_187_4000", "HTA12_EXT213_4000", "HTA12_108_4000", "HTA12_108_4001", "HTA12_109_4000", "HTA12_109_4001", "HTA12_110_4000", "HTA12_110_4001", "HTA12_111_4000", "HTA12_111_4001", "HTA12_112_4000", "HTA12_112_4001", "HTA12_112_4002", "HTA12_167_4000", "HTA12_118_4000", "HTA12_119_4000", "HTA12_120_4002", "HTA12_123_4000", "HTA12_124_4000", "HTA12_126_4000", "HTA12_127_4002", "HTA12_129_4000", "HTA12_130_4000", "HTA12_131_4000", "HTA12_134_4000", "HTA12_135_4000", "HTA12_139_4000", "HTA12_142_4000", "HTA12_144_4000", "HTA12_145_4000", "HTA12_120_4000", "HTA12_127_4001", "HTA12_EXT35_4005", "HTA12_EXT36_4005", "HTA12_EXT37_4005", "HTA12_85_4005", "HTA12_86_4005", "HTA12_87_4005", "HTA12_88_4005", "HTA12_89_4005", "HTA12_90_4005", "HTA12_91_4005", "HTA12_92_4005", "HTA12_93_4005", "HTA12_94_4005", "HTA12_95_4005", "HTA12_96_4005", "HTA12_97_4005", "HTA12_98_4005", "HTA12_101_4005", "HTA12_101_4006", "HTA12_102_4005", "HTA12_102_4006", "HTA12_103_4005", "HTA12_103_4006", "HTA12_104_4005", "HTA12_104_4006", "HTA12_105_4005", "HTA12_106_4005", "HTA12_106_4006", "HTA12_107_4005", "HTA12_108_4005", "HTA12_108_4006", "HTA12_109_4005", "HTA12_109_4006", "HTA12_111_4005", "HTA12_111_4006", "HTA12_112_4005", "HTA12_112_4006", "HTA12_112_4007", "HTA12_113_4005", "HTA12_114_4005", "HTA12_118_4005", "HTA12_119_4005", "HTA12_120_4005", "HTA12_121_4005", "HTA12_122_4005", "HTA12_123_4005", "HTA12_124_4005", "HTA12_126_4005", "HTA12_127_4005", "HTA12_128_4005", "HTA12_129_4005", "HTA12_130_4005", "HTA12_131_4005", "HTA12_22_4005", "HTA12_132_4005", "HTA12_133_4005", "HTA12_23_4005", "HTA12_24_4005", "HTA12_134_4005", "HTA12_25_4005", "HTA12_135_4005", "HTA12_136_4005", "HTA12_137_4005", "HTA12_26_4005", "HTA12_138_4005", "HTA12_139_4005", "HTA12_27_4005", "HTA12_140_4005", "HTA12_28_4005", "HTA12_28_4006", "HTA12_142_4005", "HTA12_30_4005", "HTA12_143_4005", "HTA12_144_4005", "HTA12_145_4005", "HTA12_31_4005", "HTA12_146_4005", "HTA12_147_4005", "HTA12_148_4005", "HTA12_148_4006", "HTA12_149_4005", "HTA12_150_4005", "HTA12_32_4005", "HTA12_151_4005", "HTA12_152_4005", "HTA12_153_4005", "HTA12_154_4005", "HTA12_155_4005", "HTA12_156_4005", "HTA12_158_4005", "HTA12_159_4005", "HTA12_160_4005", "HTA12_161_4005", "HTA12_162_4005", "HTA12_163_4005", "HTA12_164_4005", "HTA12_165_4005", "HTA12_166_4005", "HTA12_167_4005", "HTA12_168_4005", "HTA12_169_4005", "HTA12_169_4006", "HTA12_170_4005", "HTA12_171_4005", "HTA12_172_4005", "HTA12_173_4005", "HTA12_174_4005", "HTA12_175_4005", "HTA12_176_4005", "HTA12_177_4005", "HTA12_178_4005", "HTA12_179_4005", "HTA12_180_4005", "HTA12_181_4005", "HTA12_182_4005", "HTA12_183_4005", "HTA12_184_4005", "HTA12_185_4005", "HTA12_186_4005", "HTA12_187_4005", "HTA12_188_4005", "HTA12_189_4005", "HTA12_190_4005", "HTA12_191_4005", "HTA12_192_4005", "HTA12_193_4005", "HTA12_194_4005", "HTA12_195_4005", "HTA12_195_4006", "HTA12_196_4005", "HTA12_196_4006", "HTA12_197_4005", "HTA12_198_4005", "HTA12_199_4005", "HTA12_200_4005", "HTA12_201_4005", "HTA12_202_4005", "HTA12_203_4005", "HTA12_205_4005", "HTA12_206_4005", "HTA12_207_4005", "HTA12_208_4005", "HTA12_209_4005", "HTA12_210_4005", "HTA12_211_4005", "HTA12_212_4005", "HTA12_EXT213_4005", "HTA12_76_4005", "HTA12_214_4005", "HTA12_215_4006", "HTA12_215_4005", "HTA12_217_4005", "HTA12_218_4005", "HTA12_219_4005", "HTA12_220_4005", "HTA12_221_4005", "HTA12_222_4005", "HTA12_223_4005", "HTA12_224_4005", "HTA12_225_4005", "HTA12_226_4005" ], "Eutils Date": "2023 Nov", "Eutils Title": "Epigenetic regulation during cancer transitions across 11 tumour types.", "Eutils Journal": "Nature", "Eutils Sort Date": "2023/11/01 00:00", "Eutils Authors": "Terekhanova NV, Karpova A, Liang WW, Strzalkowski A, Chen S, Li Y, Southard-Smith AN, Iglesia MD, Wendl MC, Jayasinghe RG, Liu J, Song Y, Cao S, Houston A, Liu X, Wyczalkowski MA, Lu RJ, Caravan W, Shinkle A, Naser Al Deen N, Herndon JM, Mudd J, Ma C, Sarkar H, Sato K, Ibrahim OM, Mo CK, Chasnoff SE, Porta-Pardo E, Held JM, Pachynski R, Schwarz JK, Gillanders WE, Kim AH, Vij R, DiPersio JF, Puram SV, Chheda MG, Fuh KC, DeNardo DG, Fields RC, Chen F, Raphael BJ, Ding L", "Eutils DOI": "10.1038/s41586-023-06682-5", "Cited In Number": 124, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=37914932" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233303", "HTAN Center ID": "HTA12", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41467-023-37211-7", "Title": "Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma", "Authors": "Yige Wu, Nadezhda V Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, Siqi Chen, Chia-Kuei Mo, Song Cao, Yize Li, Alla Karpova, Ruiyang Liu, Yanyan Zhao, Andrew Shinkle, Ilya Strunilin, Cody Weimholt, Kazuhito Sato, Lijun Yao, Mamatha Serasanambati, Xiaolu Yang, Matthew Wyczalkowski, Houxiang Zhu, Daniel Cui Zhou, Reyka G Jayasinghe, Daniel Mendez, Michael C Wendl, David Clark, Chelsea Newton, Yijun Ruan, Melissa A Reimers, Russell K Pachynski, Chris Kinsinger, Scott Jewell, Daniel W Chan, Hui Zhang, Aadel A Chaudhuri, Milan G Chheda, Benjamin D Humphreys, Mehdi Mesri, Henry Rodriguez, James J Hsieh, Li Ding, Feng Chen", "Corresponding Author": "Li Ding", "Corresponding Author ORCID": "https://orcid.org/0000-0003-1517-2975", "Year of Publication": "2023", "Location of Publication": "Nature Communications", "Publication Abstract": "Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, respectively, with matched bulk proteogenomics data. By identifying 20 tumor-specific markers through a multi-omics tiered approach, we reveal an association between higher ceruloplasmin (CP) expression and reduced survival. CP knockdown, combined with spatial transcriptomics, suggests a role for CP in regulating hyalinized stroma and tumor-stroma interactions in ccRCC. Intratumoral heterogeneity analysis portrays tumor cell-intrinsic inflammation and epithelial-mesenchymal transition (EMT) as two distinguishing features of tumor subpopulations. Finally, BAP1 mutations are associated with widespread reduction of chromatin accessibility, while PBRM1 mutations generally increase accessibility, with the former affecting five times more accessible peaks than the latter. These integrated analyses reveal the cellular architecture of ccRCC, providing insights into key markers and pathways in ccRCC tumorigenesis.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/36973268/", "Publication contains HTAN ID": "No", "Data Type": "10X Visium,scATAC-seq,scRNA-seq", "Tool": "No", "Supporting Link": "https://portal.gdc.cancer.gov/projects/CPTAC-3", "Supporting Link Description": "CPTAC project page", "Publication-associated HTAN Parent Data File ID": [ "HTA12_167_1040", "HTA12_167_1041", "HTA12_33_1001", "HTA12_33_1002", "HTA12_34_1001", "HTA12_34_1002", "HTA12_167_2020", "HTA12_167_3000", "HTA12_167_3001", "HTA12_167_3002", "HTA12_33_2001", "HTA12_34_2001", "HTA12_33_3001", "HTA12_33_3002", "HTA12_33_3003", "HTA12_33_3006", "HTA12_34_3001", "HTA12_34_3002", "HTA12_34_3003", "HTA12_34_3006", "HTA12_33_1003", "HTA12_34_1003", "HTA12_33_3005", "HTA12_34_3005", "HTA12_33_3004", "HTA12_34_3004", "HTA12_167_1020", "HTA12_167_1021", "HTA12_167_1022", "HTA12_167_1023", "HTA12_167_2010", "HTA12_167_3010", "HTA12_167_3013", "HTA12_167_3012", "HTA12_167_3011", "HTA12_167_4000", "HTA12_167_4005" ], "Eutils Date": "2023 Mar 27", "Eutils Title": "Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.", "Eutils Journal": "Nature communications", "Eutils Sort Date": "2023/03/27 00:00", "Eutils Authors": "Wu Y, Terekhanova NV, Caravan W, Naser Al Deen N, Lal P, Chen S, Mo CK, Cao S, Li Y, Karpova A, Liu R, Zhao Y, Shinkle A, Strunilin I, Weimholt C, Sato K, Yao L, Serasanambati M, Yang X, Wyczalkowski M, Zhu H, Zhou DC, Jayasinghe RG, Mendez D, Wendl MC, Clark D, Newton C, Ruan Y, Reimers MA, Pachynski RK, Kinsinger C, Jewell S, Chan DW, Zhang H, Chaudhuri AA, Chheda MG, Humphreys BD, Mesri M, Rodriguez H, Hsieh JJ, Ding L, Chen F", "Eutils DOI": "10.1038/s41467-023-37211-7", "Cited In Number": 35, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=36973268" }, { "Component": "PublicationManifest", "HTAN Grant ID": "CA233303", "HTAN Center ID": "HTA12", "Publication Content Type": "Published manuscript", "DOI": "https://doi.org/10.1038/s41588-022-01157-1", "Title": "Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer", "Authors": "Daniel Cui Zhou, Reyka G Jayasinghe, Siqi Chen, John M Herndon, Michael D Iglesia, Pooja Navale, Michael C Wendl, Wagma Caravan, Kazuhito Sato, Erik Storrs, Chia-Kuei Mo, Jingxian Liu, Austin N Southard-Smith, Yige Wu, Nataly Naser Al Deen, John M Baer, Robert S Fulton, Matthew A Wyczalkowski, Ruiyang Liu, Catrina C Fronick, Lucinda A Fulton, Andrew Shinkle, Lisa Thammavong, Houxiang Zhu, Hua Sun, Liang-Bo Wang, Yize Li, Chong Zuo, Joshua F McMichael, Sherri R Davies, Elizabeth L Appelbaum, Keenan J Robbins, Sara E Chasnoff, Xiaolu Yang, Ashley N Reeb, Clara Oh, Mamatha Serasanambati, Preet Lal, Rajees Varghese, Jay R Mashl, Jennifer Ponce, Nadezhda V Terekhanova, Lijun Yao, Fang Wang, Lijun Chen, Michael Schnaubelt, Rita Jui-Hsien Lu, Julie K Schwarz, Sidharth V Puram, Albert H Kim, Sheng-Kwei Song, Kooresh I Shoghi, Ken S Lau, Tao Ju, Ken Chen, Deyali Chatterjee, William G Hawkins, Hui Zhang, Samuel Achilefu, Milan G Chheda, Stephen T Oh, William E Gillanders, Feng Chen, David G DeNardo, Ryan C Fields, Li Ding", "Corresponding Author": "David G DeNardo,Ryan C Fields,Li Ding", "Corresponding Author ORCID": "https://orcid.org/0000-0002-3655-5783,https://orcid.org/0000-0001-6176-8943,https://orcid.org/0000-0003-1517-2975", "Year of Publication": "2022", "Location of Publication": "Nature Genetics", "Publication Abstract": "Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-na\u00efve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of proliferation, KRAS signaling, cell stress and epithelial-to-mesenchymal transition. Mapping mutations and copy number events distinguished tumor populations from normal and transitional cells, including acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasia. Pathology-assisted deconvolution of spatial transcriptomic data identified tumor and transitional subpopulations with distinct histological features. We showed coordinated expression of TIGIT in exhausted and regulatory T cells and Nectin in tumor cells. Chemo-resistant samples contain a threefold enrichment of inflammatory cancer-associated fibroblasts that upregulate metallothioneins. Our study reveals a deeper understanding of the intricate substructure of pancreatic ductal adenocarcinoma tumors that could help improve therapy for patients with this disease.", "License": "CC-BY-4.0", "PMID": "https://pubmed.ncbi.nlm.nih.gov/35995947/", "Publication contains HTAN ID": "No", "Data Type": "10X Visium,Bulk DNA,Bulk RNA-seq,scATAC-seq,scRNA-seq,H&E,IMC", "Tool": "", "Supporting Link": "https://github.com/ding-lab/", "Supporting Link Description": "The code for the mutation mapping from bulk to single cells can be found at: https://github.com/ding-lab/10Xmapping. Code for inferCNV post processing can be found at: https://github.com/ding-lab/infer_cnv_postprocesssing.git. Code for germline wrapper variant calling can be found at: https://github.com/ding-lab/germlinewrapper.", "Publication-associated HTAN Parent Data File ID": [ "HTA12_1_1001", "HTA12_1_1002", "HTA12_1_2001", "HTA12_1_3001", "HTA12_1_3002", "HTA12_1_3003", "HTA12_1_1023", "HTA12_1_1024", "HTA12_1_1025", "HTA12_1_1026", "HTA12_1_1101", "HTA12_1_1102", "HTA12_1_1103", "HTA12_1_1104", "HTA12_1_1105", "HTA12_1_1106", "HTA12_1_1107", "HTA12_1_1108", "HTA12_1_1109", "HTA12_1_1110", "HTA12_1_1111", "HTA12_1_1112", "HTA12_1_1113", "HTA12_1_1114", "HTA12_1_1115", "HTA12_1_1003", "HTA12_1_1004", "HTA12_1_2002", "HTA12_1_3004", "HTA12_1_3005", "HTA12_1_3006", "HTA12_1_1005", "HTA12_1_1006", "HTA12_1_2003", "HTA12_1_3007", "HTA12_1_3008", "HTA12_1_3009", "HTA12_1_1007", "HTA12_1_1008", "HTA12_1_1009", "HTA12_1_1010", "HTA12_1_1011", "HTA12_1_1012", "HTA12_1_1013", "HTA12_1_1014", "HTA12_1_1015", "HTA12_1_1016", "HTA12_1_1017", "HTA12_1_1018", "HTA12_1_1019", "HTA12_1_1020", "HTA12_1_1021", 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"HTA12_15_3010", "HTA12_15_3011", "HTA12_15_3012", "HTA12_15_1001", "HTA12_15_1002", "HTA12_15_1007", "HTA12_15_1008", "HTA12_15_1009", "HTA12_15_1010", "HTA12_15_1011", "HTA12_15_1012", "HTA12_15_1015", "HTA12_15_1016", "HTA12_15_1017", "HTA12_15_1018", "HTA12_15_1019", "HTA12_15_1020", "HTA12_16_1003", "HTA12_16_1004", "HTA12_16_2001", "HTA12_16_3001", "HTA12_16_3002", "HTA12_16_3003", "HTA12_16_1019", "HTA12_16_1020", "HTA12_16_1101", "HTA12_16_1102", "HTA12_16_1103", "HTA12_16_1104", "HTA12_16_1105", "HTA12_16_1106", "HTA12_16_1107", "HTA12_16_1108", "HTA12_16_1029", "HTA12_16_1030", "HTA12_16_1109", "HTA12_16_1110", "HTA12_16_1111", "HTA12_16_1005", "HTA12_16_1006", "HTA12_16_2002", "HTA12_16_3004", "HTA12_16_3005", "HTA12_16_3006", "HTA12_16_1015", "HTA12_16_1016", "HTA12_16_1017", "HTA12_16_1018", "HTA12_16_2003", "HTA12_16_3007", "HTA12_16_3008", "HTA12_16_3009", "HTA12_16_1025", "HTA12_16_1026", "HTA12_16_1027", "HTA12_16_1028", "HTA12_16_2004", "HTA12_16_3010", "HTA12_16_3011", "HTA12_16_3012", "HTA12_16_1001", "HTA12_16_1002", "HTA12_16_1011", "HTA12_16_1012", "HTA12_16_1013", "HTA12_16_1014", "HTA12_16_1021", "HTA12_16_1022", "HTA12_16_1023", "HTA12_16_1024", "HTA12_16_1031", "HTA12_16_1032", "HTA12_16_1033", "HTA12_16_1034", "HTA12_16_1009", "HTA12_16_1010", "HTA12_16_1007", "HTA12_16_1008", "HTA12_17_1003", "HTA12_17_1004", "HTA12_17_2001", "HTA12_17_3001", "HTA12_17_3002", "HTA12_17_3003", "HTA12_17_1015", "HTA12_17_1016", "HTA12_17_2003", "HTA12_17_3007", "HTA12_17_3008", "HTA12_17_3009", "HTA12_17_1101", "HTA12_17_1102", "HTA12_17_1103", "HTA12_17_1001", "HTA12_17_1002", "HTA12_17_1007", "HTA12_17_1008", "HTA12_17_1005", "HTA12_17_1006", "HTA12_17_1013", "HTA12_17_1014", "HTA12_17_1011", "HTA12_17_1012", "HTA12_17_1019", "HTA12_17_1020", "HTA12_17_1017", "HTA12_17_1018", "HTA12_17_1009", "HTA12_17_1010", "HTA12_17_2002", "HTA12_17_3004", "HTA12_17_3005", "HTA12_17_3006", "HTA12_18_1001", "HTA12_18_1002", "HTA12_18_1102", "HTA12_18_1101", "HTA12_18_1009", "HTA12_18_1010", "HTA12_18_1007", "HTA12_18_1008", "HTA12_18_1013", "HTA12_18_1014", "HTA12_18_1011", "HTA12_18_1012", "HTA12_18_1003", "HTA12_18_1004", "HTA12_18_2002", "HTA12_18_3004", "HTA12_18_3005", "HTA12_18_3006", "HTA12_18_1005", "HTA12_18_1006", "HTA12_18_2003", "HTA12_18_3007", "HTA12_18_3008", "HTA12_18_3009", "HTA12_18_2001", "HTA12_18_3001", "HTA12_18_3002", "HTA12_18_3003", "HTA12_19_1001", "HTA12_19_1002", "HTA12_19_1015", "HTA12_19_1016", "HTA12_19_2003", "HTA12_19_3007", "HTA12_19_3008", "HTA12_19_3009", "HTA12_19_1101", "HTA12_19_1102", "HTA12_19_1103", "HTA12_19_1007", "HTA12_19_1008", "HTA12_19_1005", "HTA12_19_1006", "HTA12_19_1013", "HTA12_19_1014", "HTA12_19_1011", "HTA12_19_1012", "HTA12_19_1020", "HTA12_19_1019", "HTA12_19_1017", "HTA12_19_1018", "HTA12_19_1003", "HTA12_19_1004", "HTA12_19_2001", "HTA12_19_3001", "HTA12_19_3002", "HTA12_19_3003", "HTA12_19_1009", "HTA12_19_1010", "HTA12_19_2002", "HTA12_19_3004", "HTA12_19_3005", "HTA12_19_3006", "HTA12_2_1001", "HTA12_2_1002", "HTA12_2_1027", "HTA12_2_1028", "HTA12_2_1025", "HTA12_2_1026", "HTA12_2_1101", "HTA12_2_1105", "HTA12_2_1102", "HTA12_2_1103", "HTA12_2_1104", "HTA12_2_1106", "HTA12_2_1107", "HTA12_2_1108", "HTA12_2_1109", "HTA12_2_1110", "HTA12_2_1111", "HTA12_2_1112", "HTA12_2_1113", "HTA12_2_1114", "HTA12_2_1115", "HTA12_2_1011", "HTA12_2_1012", "HTA12_2_1013", "HTA12_2_1014", "HTA12_2_1015", "HTA12_2_1016", "HTA12_2_1029", "HTA12_2_1030", "HTA12_2_1031", "HTA12_2_1032", "HTA12_2_1033", "HTA12_2_1034", "HTA12_2_1035", "HTA12_2_1036", "HTA12_2_1037", "HTA12_2_1038", "HTA12_2_1039", "HTA12_2_1040", "HTA12_2_2001", "HTA12_2_3001", "HTA12_2_3002", "HTA12_2_3003", "HTA12_2_1041", "HTA12_2_1042", "HTA12_2_1043", "HTA12_2_1044", "HTA12_2_1045", "HTA12_2_1046", "HTA12_2_1003", "HTA12_2_1004", "HTA12_2_1005", "HTA12_2_1006", "HTA12_2_1007", "HTA12_2_1008", "HTA12_2_1009", "HTA12_2_1010", "HTA12_2_2002", "HTA12_2_3004", "HTA12_2_3005", "HTA12_2_3006", "HTA12_2_1017", "HTA12_2_1018", "HTA12_2_1019", "HTA12_2_1020", "HTA12_2_1021", "HTA12_2_1022", "HTA12_2_1023", "HTA12_2_1024", "HTA12_2_2003", "HTA12_2_3007", "HTA12_2_3008", "HTA12_2_3009", "HTA12_20_1001", "HTA12_20_1002", "HTA12_20_1101", "HTA12_20_1102", "HTA12_20_1003", "HTA12_20_1004", "HTA12_20_2001", "HTA12_20_3001", "HTA12_20_3002", "HTA12_20_3003", "HTA12_20_1007", "HTA12_20_1008", "HTA12_20_2002", "HTA12_20_3004", "HTA12_20_3005", "HTA12_20_3006", "HTA12_20_1013", "HTA12_20_1014", "HTA12_20_2003", "HTA12_20_3007", "HTA12_20_3008", "HTA12_20_3009", "HTA12_20_1009", "HTA12_20_1010", "HTA12_20_1015", "HTA12_20_1016", "HTA12_20_1005", "HTA12_20_1006", "HTA12_20_1011", "HTA12_20_1012", "HTA12_20_1018", "HTA12_20_1017", "HTA12_21_1001", "HTA12_21_1002", "HTA12_21_1019", "HTA12_21_1020", "HTA12_21_1101", "HTA12_21_1102", "HTA12_21_1103", "HTA12_21_1003", "HTA12_21_1004", "HTA12_21_2001", "HTA12_21_3001", "HTA12_21_3002", "HTA12_21_3003", "HTA12_21_1009", "HTA12_21_1010", "HTA12_21_2002", "HTA12_21_3004", "HTA12_21_3005", "HTA12_21_3006", "HTA12_21_1015", "HTA12_21_1016", "HTA12_21_2003", "HTA12_21_3007", "HTA12_21_3008", "HTA12_21_3009", "HTA12_21_1005", "HTA12_21_1006", "HTA12_21_1011", "HTA12_21_1012", "HTA12_21_1017", "HTA12_21_1018", "HTA12_21_1007", "HTA12_21_1008", "HTA12_21_1013", "HTA12_21_1014", "HTA12_22_1001", "HTA12_22_1002", "HTA12_22_1004", "HTA12_22_1003", "HTA12_22_1005", "HTA12_22_1006", "HTA12_22_1012", "HTA12_22_1013", "HTA12_22_2001", "HTA12_22_2020", "HTA12_22_3001", "HTA12_22_3002", "HTA12_22_3003", "HTA12_22_1020", "HTA12_22_1021", "HTA12_22_1022", "HTA12_22_2010", "HTA12_22_3020", "HTA12_22_3021", "HTA12_22_3022", "HTA12_22_3023", "HTA12_22_4000", "HTA12_22_4005", "HTA12_22_1007", "HTA12_22_1008", "HTA12_22_2002", "HTA12_22_3004", "HTA12_22_3005", "HTA12_22_3006", "HTA12_22_3009", "HTA12_22_1011", "HTA12_22_3007", "HTA12_22_3008", "HTA12_22_1009", "HTA12_22_1010", "HTA12_23_1001", "HTA12_23_1002", "HTA12_23_1110", "HTA12_23_1111", "HTA12_23_1003", "HTA12_23_1004", "HTA12_23_1040", "HTA12_23_1041", "HTA12_23_2001", "HTA12_23_2020", "HTA12_23_3001", "HTA12_23_3002", "HTA12_23_3003", "HTA12_23_1020", "HTA12_23_1021", "HTA12_23_1022", "HTA12_23_2010", "HTA12_23_3020", "HTA12_23_3021", "HTA12_23_3022", "HTA12_23_3023", "HTA12_23_4000", "HTA12_23_4005", "HTA12_23_1005", "HTA12_23_1006", "HTA12_23_2002", "HTA12_23_3004", "HTA12_23_3005", "HTA12_23_3006", "HTA12_23_3009", "HTA12_23_1011", "HTA12_23_3007", "HTA12_23_3008", "HTA12_23_1007", "HTA12_23_1008", "HTA12_23_1009", "HTA12_23_1010", "HTA12_24_1001", "HTA12_24_1002", "HTA12_24_1004", "HTA12_24_1003", "HTA12_24_1110", "HTA12_24_1111", "HTA12_24_1005", "HTA12_24_1006", "HTA12_24_1112", "HTA12_24_1113", "HTA12_24_1007", "HTA12_24_1008", "HTA12_24_1040", "HTA12_24_1041", "HTA12_24_2001", "HTA12_24_2020", "HTA12_24_3001", "HTA12_24_3002", "HTA12_24_3003", "HTA12_24_1020", "HTA12_24_1021", "HTA12_24_1022", "HTA12_24_2010", "HTA12_24_3020", "HTA12_24_3021", "HTA12_24_3022", "HTA12_24_3023", "HTA12_24_4000", "HTA12_24_4005", "HTA12_24_1009", "HTA12_24_1010", "HTA12_24_2002", "HTA12_24_3004", "HTA12_24_3005", "HTA12_24_3006", "HTA12_24_3009", "HTA12_24_1013", "HTA12_24_3007", "HTA12_24_3008", "HTA12_24_1011", "HTA12_24_1012", "HTA12_24_2003", "HTA12_24_3015", "HTA12_24_3010", "HTA12_24_3011", "HTA12_24_3014", "HTA12_24_1014", "HTA12_24_3012", "HTA12_24_3013", "HTA12_25_1001", "HTA12_25_1002", "HTA12_25_1003", "HTA12_25_1004", "HTA12_25_1110", "HTA12_25_1111", "HTA12_25_1005", "HTA12_25_1006", "HTA12_25_1040", "HTA12_25_1041", "HTA12_25_2001", "HTA12_25_2020", "HTA12_25_3001", "HTA12_25_3002", "HTA12_25_3003", "HTA12_25_1021", "HTA12_25_1022", "HTA12_25_1023", "HTA12_25_1024", "HTA12_25_1025", "HTA12_25_1026", "HTA12_25_2010", "HTA12_25_3120", "HTA12_25_3121", "HTA12_25_3122", "HTA12_25_3123", "HTA12_25_4000", "HTA12_25_4005", "HTA12_25_1007", "HTA12_25_1008", "HTA12_25_1112", "HTA12_25_1113", "HTA12_25_1009", "HTA12_25_1010", "HTA12_25_2002", "HTA12_25_3004", "HTA12_25_3005", "HTA12_25_3006", "HTA12_25_3009", "HTA12_25_1017", "HTA12_25_3007", "HTA12_25_3008", "HTA12_25_1011", "HTA12_25_1012", "HTA12_25_2003", "HTA12_25_3010", "HTA12_25_3011", "HTA12_25_3012", "HTA12_25_3015", "HTA12_25_1018", "HTA12_25_3013", "HTA12_25_3014", "HTA12_25_1013", "HTA12_25_1014", "HTA12_25_2004", "HTA12_25_3016", "HTA12_25_3017", "HTA12_25_3018", "HTA12_25_3021", "HTA12_25_1019", "HTA12_25_3019", "HTA12_25_3020", "HTA12_25_1015", "HTA12_25_1016", "HTA12_25_2005", "HTA12_25_3022", "HTA12_25_3023", "HTA12_25_3024", "HTA12_25_3027", "HTA12_25_1020", "HTA12_25_3025", "HTA12_25_3026", "HTA12_26_1001", "HTA12_26_1002", "HTA12_26_1003", "HTA12_26_1004", "HTA12_26_1110", "HTA12_26_1111", "HTA12_26_1005", "HTA12_26_1006", "HTA12_26_1112", "HTA12_26_1113", "HTA12_26_1007", "HTA12_26_1008", "HTA12_26_1040", "HTA12_26_1041", "HTA12_26_2001", "HTA12_26_2020", "HTA12_26_3001", "HTA12_26_3002", "HTA12_26_3003", "HTA12_26_1020", "HTA12_26_1021", "HTA12_26_1022", "HTA12_26_2010", "HTA12_26_3020", "HTA12_26_3021", "HTA12_26_3022", "HTA12_26_3023", "HTA12_26_4000", "HTA12_26_4005", "HTA12_26_1009", "HTA12_26_1010", "HTA12_26_2002", "HTA12_26_3004", "HTA12_26_3005", "HTA12_26_3006", "HTA12_26_3009", "HTA12_26_1013", "HTA12_26_3007", "HTA12_26_3008", "HTA12_26_1011", "HTA12_26_1012", "HTA12_26_2003", "HTA12_26_3010", "HTA12_26_3011", "HTA12_26_3012", "HTA12_26_3015", "HTA12_26_1014", "HTA12_26_3013", "HTA12_26_3014", "HTA12_27_1002", "HTA12_27_1001", "HTA12_27_1003", "HTA12_27_1004", "HTA12_27_1005", "HTA12_27_1006", "HTA12_27_1110", "HTA12_27_1111", "HTA12_27_1007", "HTA12_27_1008", "HTA12_27_1040", "HTA12_27_1041", "HTA12_27_2001", "HTA12_27_2020", "HTA12_27_3001", "HTA12_27_3002", "HTA12_27_3003", "HTA12_27_1020", "HTA12_27_1021", "HTA12_27_1022", "HTA12_27_1023", "HTA12_27_1024", "HTA12_27_1025", "HTA12_27_2010", "HTA12_27_3020", "HTA12_27_3021", "HTA12_27_3022", "HTA12_27_3023", "HTA12_27_4000", "HTA12_27_4005", "HTA12_27_1009", "HTA12_27_1010", "HTA12_27_2002", "HTA12_27_3004", "HTA12_27_3005", "HTA12_27_3006", "HTA12_27_3009", "HTA12_27_1011", "HTA12_27_3007", "HTA12_27_3008", "HTA12_28_1001", "HTA12_28_1002", "HTA12_28_1004", "HTA12_28_1003", "HTA12_28_1110", "HTA12_28_1111", "HTA12_28_1005", "HTA12_28_1006", "HTA12_28_1112", "HTA12_28_1113", "HTA12_28_1007", "HTA12_28_1008", "HTA12_28_1040", "HTA12_28_1041", "HTA12_28_2001", "HTA12_28_2020", "HTA12_28_3001", "HTA12_28_3002", "HTA12_28_3003", "HTA12_28_1020", "HTA12_28_1021", "HTA12_28_1022", "HTA12_28_1023", "HTA12_28_1024", "HTA12_28_1025", "HTA12_28_2010", "HTA12_28_3020", "HTA12_28_3022", "HTA12_28_3024", "HTA12_28_3026", "HTA12_28_4000", "HTA12_28_4005", "HTA12_28_1009", "HTA12_28_1010", "HTA12_28_2002", "HTA12_28_3009", "HTA12_28_3004", "HTA12_28_3005", "HTA12_28_3008", "HTA12_28_1011", "HTA12_28_3006", "HTA12_28_3007", "HTA12_28_1042", "HTA12_28_1043", "HTA12_28_2021", "HTA12_28_1026", "HTA12_28_1027", "HTA12_28_1028", "HTA12_28_2011", "HTA12_28_3021", "HTA12_28_3023", "HTA12_28_3025", "HTA12_28_3027", "HTA12_28_4001", "HTA12_28_4006", "HTA12_29_1001", "HTA12_29_1002", "HTA12_29_1003", "HTA12_29_1004", "HTA12_29_2001", "HTA12_29_3001", "HTA12_29_3002", "HTA12_29_3003", "HTA12_29_1005", "HTA12_29_1006", "HTA12_29_2002", "HTA12_29_3004", "HTA12_29_3005", "HTA12_29_3006", "HTA12_29_3009", "HTA12_29_1011", "HTA12_29_3007", "HTA12_29_3008", "HTA12_29_1008", "HTA12_29_1007", "HTA12_29_1009", "HTA12_29_1010", "HTA12_3_1001", "HTA12_3_1002", "HTA12_3_1003", "HTA12_3_1004", "HTA12_3_1043", "HTA12_3_1044", "HTA12_3_1045", "HTA12_3_1046", "HTA12_3_1047", "HTA12_3_1048", "HTA12_3_1049", "HTA12_3_1050", "HTA12_3_2004", "HTA12_3_3010", "HTA12_3_3011", "HTA12_3_3012", "HTA12_3_1101", "HTA12_3_1102", "HTA12_3_1103", "HTA12_3_1104", "HTA12_3_1105", "HTA12_3_1106", "HTA12_3_1107", "HTA12_3_1108", "HTA12_3_1109", "HTA12_3_1110", "HTA12_3_1111", "HTA12_3_1112", "HTA12_3_1051", "HTA12_3_1052", "HTA12_3_1053", "HTA12_3_1054", "HTA12_3_1005", "HTA12_3_1006", "HTA12_3_1007", "HTA12_3_1008", "HTA12_3_1009", "HTA12_3_1010", "HTA12_3_1011", "HTA12_3_1012", "HTA12_3_2001", "HTA12_3_3001", "HTA12_3_3002", "HTA12_3_3003", "HTA12_3_1013", "HTA12_3_1014", "HTA12_3_1015", "HTA12_3_1016", "HTA12_3_1017", "HTA12_3_1018", "HTA12_3_1019", "HTA12_3_1020", "HTA12_3_1021", "HTA12_3_1022", "HTA12_3_2002", "HTA12_3_3004", "HTA12_3_3005", "HTA12_3_3006", "HTA12_3_1023", "HTA12_3_1024", "HTA12_3_1025", "HTA12_3_1026", "HTA12_3_1027", "HTA12_3_1028", "HTA12_3_1029", "HTA12_3_1030", "HTA12_3_1031", "HTA12_3_1032", "HTA12_3_1033", "HTA12_3_1034", "HTA12_3_1035", "HTA12_3_1036", "HTA12_3_2003", "HTA12_3_3007", "HTA12_3_3008", "HTA12_3_3009", "HTA12_3_1037", "HTA12_3_1038", "HTA12_3_1039", "HTA12_3_1040", "HTA12_3_1041", "HTA12_3_1042", "HTA12_30_1002", "HTA12_30_1001", "HTA12_30_1110", "HTA12_30_1111", "HTA12_30_1003", "HTA12_30_1004", "HTA12_30_1040", "HTA12_30_1041", "HTA12_30_2001", "HTA12_30_2020", "HTA12_30_3001", "HTA12_30_3002", "HTA12_30_3003", "HTA12_30_1020", "HTA12_30_1021", "HTA12_30_1022", "HTA12_30_2010", "HTA12_30_3020", "HTA12_30_3021", "HTA12_30_3022", "HTA12_30_3023", "HTA12_30_4000", "HTA12_30_4005", "HTA12_30_1005", "HTA12_30_1006", "HTA12_30_2002", "HTA12_30_3004", "HTA12_30_3005", "HTA12_30_3006", "HTA12_30_3009", "HTA12_30_1012", "HTA12_30_3007", "HTA12_30_3008", "HTA12_30_1007", "HTA12_30_1008", "HTA12_30_1112", "HTA12_30_1113", "HTA12_30_1009", "HTA12_30_1010", "HTA12_31_1002", "HTA12_30_6", "HTA12_31_1110", "HTA12_31_1111", "HTA12_31_1003", "HTA12_31_1004", "HTA12_31_1040", "HTA12_31_1041", "HTA12_31_2001", "HTA12_31_2020", "HTA12_31_3001", "HTA12_31_3002", "HTA12_31_3003", "HTA12_31_1020", "HTA12_31_1021", "HTA12_31_1022", "HTA12_31_2010", "HTA12_31_3020", "HTA12_31_3021", "HTA12_31_3022", "HTA12_31_3023", "HTA12_31_4000", "HTA12_31_4005", "HTA12_31_1005", "HTA12_31_1006", "HTA12_31_2002", "HTA12_31_3004", "HTA12_31_3005", "HTA12_31_3006", "HTA12_31_3009", "HTA12_31_1011", "HTA12_31_3007", "HTA12_31_3008", "HTA12_31_1007", "HTA12_31_1008", "HTA12_31_1112", "HTA12_31_1113", "HTA12_31_1009", "HTA12_31_1010", "HTA12_32_1001", "HTA12_32_1002", "HTA12_32_1040", "HTA12_32_1041", "HTA12_32_2001", "HTA12_32_2020", "HTA12_32_3001", "HTA12_32_3002", "HTA12_32_3003", "HTA12_32_1020", "HTA12_32_1021", "HTA12_32_1022", "HTA12_32_1023", "HTA12_32_1024", "HTA12_32_1025", "HTA12_32_2010", "HTA12_32_3020", "HTA12_32_3021", "HTA12_32_3022", "HTA12_32_3023", "HTA12_32_4000", "HTA12_32_4005", "HTA12_32_1010", "HTA12_32_1011" ], "Eutils Date": "2022 Sep", "Eutils Title": "Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer.", "Eutils Journal": "Nature genetics", "Eutils Sort Date": "2022/09/01 00:00", "Eutils Authors": "Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo CK, Liu J, Southard-Smith AN, Wu Y, Naser Al Deen N, Baer JM, Fulton RS, Wyczalkowski MA, Liu R, Fronick CC, Fulton LA, Shinkle A, Thammavong L, Zhu H, Sun H, Wang LB, Li Y, Zuo C, McMichael JF, Davies SR, Appelbaum EL, Robbins KJ, Chasnoff SE, Yang X, Reeb AN, Oh C, Serasanambati M, Lal P, Varghese R, Mashl JR, Ponce J, Terekhanova NV, Yao L, Wang F, Chen L, Schnaubelt M, Lu RJ, Schwarz JK, Puram SV, Kim AH, Song SK, Shoghi KI, Lau KS, Ju T, Chen K, Chatterjee D, Hawkins WG, Zhang H, Achilefu S, Chheda MG, Oh ST, Gillanders WE, Chen F, DeNardo DG, Fields RC, Ding L", "Eutils DOI": "10.1038/s41588-022-01157-1", "Cited In Number": 150, "Cited In Link": "https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed_citedin&from_uid=35995947" } ]