Alexander Diehl
Sriram Neelamegham
Theodore Groth
2022
GlycoEnzOnto is an ontology which describes the molecular functions and metabolic pathway involvement of 403 glycosylation-related genes, called glycogenes. There are four main kinds of glycosylation-related pathways modeled in GlycoEnzOnto:
1. Metabolism of glycosylation donor substrates: Donor substrates are classified as any molecule that is added onto a glycan structure. These molecules include:
* Nucleotide Sugars, and
* Monosaccharide substituents, which includes sulfate, phosphate, and ethanolamine for example
2. Transport of donor substrates into glycosylation compartments such as the endoplasmic reticulum and Golgi
3. Glycan biosynthesis: these pathways describe the sequences of metabolic reactions whereby glycans are synthesized. There are three phases of glycan biosynthesis modeled in GlycoEnzOnto:
* Core structure biosynthesis: these pathways are responsible for creating the base structures for various glycan types (N-linked, O-linked, Glycosphingolipids, Glycosaminoglycans, etc.) Enzymes involved in these pathways are unique to the kinds of glycans they synthesize.
* Elongation and Branching pathways: these pathways increase the size and degree of branching of glycan structures, and can take place on a variety of glycan types. These pathways include synthesis of LacNAc structures, as well as the glycosaminoglycan polymerization reactions.
* Capping pathways: these pathways transfer monosaccharides and substituents that preclude any further extension of a glycan structure.
4. Degradation of glycans: These pathways describe how the various glycan types are degraded. These classes are defined in terms of i. the type of glycan being degraded, and ii. the compartment in which the glycan is degraded.
The mechanistic functions of each enzyme are encoded as a single string in the form of reaction rules and reaction constraints. Included alongside the glycoenzyme pathway classification are all biological process (BP), molecular function (MF), and cellular compartment (CC) annotations from the Gene Ontology (GO). This promotes interoperability between other resources. GlycoEnzOnto pathways which were deemed to be encompassed by a GO biological process term were related with the "involved in" relationship in the Relation Ontology (RO).
https://creativecommons.org/licenses/by/4.0/
GlycoOnto
addiehl
neel
tgroth
2022-05-18T19:53:43Z
has part
has reaction rule
has constraint
has rule string
A metabolic process by which the 6-sulfated sialyl Lewis X antigen is created.
6-sulfated sialyl lewis x biosynthetic pathway
A metabolic pathway whereby fucosylation of blood group A (GalNAc(a1-3)Gal(b1-3)b-GlcNAc), B ( Gal(a1-3)Gal(b1-3)b-GlcNAc ), or O ( Gal(b1-3)b-GlcNAc ) is facilitated.
abo blood group biosynthetic pathway
A series of reactions whereby mannose is transferred to the 2 carbon of tryptophan in W-X-X-W motifs on cadherin and similar proteins.
c-linked mannose biosynthetic pathway
A sequence of metabolic events responsible for the synthesis of cytidine-5'-monophosophate n-acetylneuraminic acid.
cytidine-5'-monophosphate n-acetylneuraminic acid synthetic pathway
A series of metabolic reactions which synthesize the core structures of both chondroitin and dermatan sulfate glycosaminoglycans. Involves the addition of n-acetylgalactosamine onto the core o-xylose glycosaminoglycan structure.
chondroitin and dermatan sulfate core structure biosynthetic pathway
A series of metabolic reactions whereby heparan sulfates receive N-acetylgalactosamine and glucuronic acid in an alternating fashion, which results in greater degree of polymerization.
chondroitin and dermatan sulfate polymerization pathway
A a series of metabolic reactions where chondroitin and dermatan sulfates undergo sulfation on the N-acetylgalactosamine, glucuronic acid, or iduronic acid residues to variable degrees.
chondroitin and dermatan sulfate sulfation pathway
A sequence of catabolic reactions whereby chondroitin sulfate is degraded in the cytoplasm.
chondroitin sulfate cytoplasmic degradation pathway
A series of catabolic reactions which degrade chondroitin sulfates.
chondroitin sulfate degradation pathway
A sequence of catabolic reactions whereby chondroitin sulfate is degraded in the lysosome.
chondroitin sulfate lysosomal degradation pathway
A sequence of reactions involving the transfer of monosaccharides to the non-reducing ends of glycans which, upon transfer, precludes any other monosaccharides from being attached.
glycan capping structure biosynthetic pathway
A series of metabolic processes whereby galactose is attached to serine or threonine residues on collagen.
collagen glycosylation pathway
A series of metabolic reactions whereby galactose is added onto an O-linked N-acetylgalactosamine through the action of the galactosyltransferase C1GALT1 and its chaperone C1GALT1C1 to form the T antigen ( Gal(b1-3)GalNAc-Ser/Thr ).
core 1 type o-N-acetylgalactosamine type glycan biosynthetic pathway
A process by which N-acetylglucosamine is transferred to the T antigen to form Gal(b1-3)[GlcNAc(b1-6)]GalNAc(a1-Ser/Thr) through the action of GCNT1 or GCNT4.
core 2 type o-N-acetylgalactosamine type glycan biosynthetic pathway
A series of metabolic reactions whereby N-acetylglucosamine is added onto an O-linked N-acetylgalactosamine through the action of the B3GNT6 to form GlcNAc(b1-3)GalNAc(a1-Ser/Thr).
core 3 type o-N-acetylgalactosamine type glycan biosynthetic pathway
A process by which the Core 3 structure receives another N-acetylglucosamine structure through the action of GCNT3 to form GlcNAc(b1-3)[GlcNAc(b1-6)]GalNAc(a1-Ser/Thr).
core 4 type o-N-acetylgalactosamine type glycan biosynthetic pathway
A set of metabolic reactions responsible for the addition of the first monosaccharide onto proteins and lipids, and the biosynthesis of distinct glycan structures which determines the glycan's class.
glycan core structure biosynthetic pathway
A series of catabolic reactions which break down glycan structures in the cytoplasm.
cytoplasmic glycan degradation pathway
A sequence of catabolic reactions whereby dermatan sulfate is degraded in the cytoplasm.
dermatan sulfate cytoplasmic degradation pathway
A sequence of catabolic reactions whereby dermatan sulfate is degraded in the extracellular matrix region.
dermatan sulfate extracellular degradation pathway
A series of catabolic reactions which degrade dermatan sulfates.
dermatan sulfate degradation pathway
A sequence of catabolic reactions whereby dermatan sulfate is degraded in the lysosome.
dermatan sulfate lysosomal degradation pathway
A metabolic process by which the N-linked glycan precursor structure is synthesized onto dolichol diphosphate in the endoplasmic reticulum.
N-glycan synthesis begins on the outer ER membrane, where the human enzyme DPAGT1 first transfers a GlcNAc-1-P from UDP-GlcNAc to Dol-P. This is followed by the addition of a second GlcNAc (by ALG13/14 heterodimer) followed by five additional Man by ALG1, ALG2 and ALG11. This Man5GlcNAc2-P-P-Dol precursor is then translocated from the cytoplasm intothe ER lumen. The remaining steps of the biosynthetic pathways proceed within the ER. Here,four more Man residues are first added by ALG3, ALG9 and ALG12, all from Dol-P-Man donors. Following this, three glucose monosaccharides are added by ALG6, ALG8 and ALG10,using Dol-P-Glc as donor. Together these steps result in the formation ofthe Glc3-Man9-GlcNAc2β1-PP-Dol precursor.
dolichol precursor biosynthetic pathway
A sequence of reactions which synthesize molecules that are covalently attached to glycan structures. This includes the synthesis nucleotide sugar substrates, and molecular substituents which modify monosaccharides, such as sulfate, phosphate, and ethanolamine.
glycan molecular donor synthesis pathway
A process by which substrates for glycosylation are transported from the cytosol into other compartments.
glycan donor transport pathway
A series of metabolic reaction which synthesizes the Core M3 O-mannose structure, which involves the successive actions of B4GALNT2 adding N-acetylgalactosamine, FKTN creating a phosphodiester bond between N-acetylglucosamine and ribitol, FKRP forming another phosphodiester bond with another ribitol, and further polymerization with xylose and glucuronic acid thorugh the alternating action of RXYLT1 and B4GAT1, respectively.
α-Dystroglycan biosynthetic pathway
A series of metabolic reactions whereby glycans receive a variable number of monosaccharides that increases their degree of polymerization and degree of branching.
glycan elongation and branching biosynthetic pathway
A series of catabolic reactions which break down glycan structures in the extracellular region.
extracellular glycan degradation pathway
A series of metabolic reactions responsible for the addition of fucose onto the termini of glycan structures, thus precluding further glycan extension and modificaiton.
terminal fucosylation biosynthetic pathway
A series of metabolic reactions which initiate the synthesis of glycosaminoglycans on proteins through their core structure synthesis.
glycosaminoglycan core structure biosynthetic pathway
A series of catabolic reactions which degrade glycosaminoglycans.
glycosaminoglycan degradation pathway
A sequence of catabolic reactions whereby a glycosaminoglycan is degraded in the lysosome.
glycosaminoglycan lysosomal degradation pathway
A series of metabolic reactions which increase polysaccharide chain lengths of chondroitin, dermatan, and heparan sulfate through the action of glycosaminoglycan polymerases.
glycosaminoglycan polymerization pathway
A sequence of metabolic events responsible for the synthesis of guanosine-5'-diphosphate fucose.
guanosine-5'-diphosphate fucose synthetic pathway
A sequence of metabolic events responsible for the synthesis of guanosine-5'-diphosphate mannose.
guanosine-5'-diphosphate mannose synthetic pathway
A process by which GDP-mannose is transported from the cytoplasm to the endoplasmic reticulum.
guanosine-5'-diphosphate mannose transport
The metabolic process by which the Glycosylphosphatidylinositol (GPI) anchor is synthesized sequentially by PIG enzymes in the endoplasmic reticulum.
glycosylphosphatidylinositol anchor biosynthetic pathway
A series of metabolic reactions which initiate the synthesis of glycan onto sphingolipids and synthesize glycosphingolipid core structures.
glycosphingolipid core structure biosynthetic pathway
A sequence of catabolic reactions whereby a glycosphingolipid is degraded in the cytoplasm.
glycosphingolipid cytosolic degradation pathway
A series of catabolic reactions which degrade glycosphingolipids.
glycosphingolipid degradation pathway
A sequence of catabolic reactions whereby a glycosphingolipid is degraded in the lysosome.
glycosphingolipid lysosomal degradation pathway
The initiation of galactosylceramide via the action of UGT8.
galactosylceramide biosynthetic pathway
A series of metabolic reactions which synthesizes the Gal(b1-3)GalNAc(b1-4)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B4GALNT1, and B3GALT4, as well as subsequent sialylation.
ganglioside core structure biosynthetic pathway
The series of metabolic reactions which add glucose onto ceramide and creates glucosylceramide core structures.
glucosylceramide biosynthetic pathway
A series of metabolic reactions by which synthesizes the GalNAc(b1-3)Gal(a1-4)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, A4GALT, and B3GALNT1.
globo-series core structure biosynthetic pathway
A process by which glucose is transported into the cytoplasm.
glucose transport
A process by which glucuronic acid is covalently linked onto xenobiotics for their clearance by the excretory system.
xenobiotic glucuronidation pathway
A sequence of reactions whereby glycan structures are broken down through hydrolytic reactions cleaving glycosidic bonds or through the removal of modifying substituents.
glycan degradation pathway
The successive breakdown of a polysaccharide comprised entirely of glucose.
glycogen catabolic pathway
A series of reactions whereby glycans are initiated onto lipid molecules.
glycolipid core structure biosynthetic pathway
A sequence of anabolic and catabolic reactions responsible for the biosynthesis of glycan structures.
glycan biosynthetic pathway
A process by which a protein either promotes or hinders glycosylation through interaction with other proteins.
glycan biosynthesis regulation
A sequence of catabolic reactions whereby hyaluronic acid is degraded in the cytoplasm.
hyaluronic acid cytoplasmic degradation pathway
A process by which hyaluronic acid is degraded in the extracellular matrix.
hyaluronic acid extracellular degradation pathway
A series of catabolic reactions which degrade hyaluronic acids.
hyaluronic acid degradation pathway
A sequence of catabolic reactions whereby hyaluronic acid is degraded in the lysosome.
hyaluronic acid lysosomal degradation pathway
A series of metabolic reactions which synthesis the human natural killer 1 epitope.
human natural killer 1 epitope biosynthetic pathway
A sequence of catabolic reactions whereby heparan sulfate is degraded in the cytoplasm.
heparan sulfate cytoplasmic degradation pathway
A sequence of catabolic reactions whereby dermatan sulfate is degraded in the extracellular matrix region.
heparan sulfate extracellular degradation pathway
A series of catabolic reactions which degrade heparan sulfates.
heparan sulfate degradation pathway
A series of metabolic reactions which synthesize the core structures of heparan sulfate glycosaminoglycans. Involves the addition of n-acetylglucosamine onto the core o-xylose glycosaminoglycan structure.
heparan sulfate core structure biosynthetic pathway
A sequence of catabolic reactions whereby heparan sulfate is degraded in the lysosome.
heparan sulfate lysosome degradation pathway
A series of metabolic reactions whereby heparan sulfates receive N-acetylglucosamine and glucuronic acid in an alternating fashion, which results in greater heparan sulfate degree of polymerization.
heparan sulfate polymerization pathway
A series of metabolic reactions where heparan sulfates undergo sulfation on the N-acetylglucosamine, glucuronic acid, or iduronic acid residues to variable degrees.
heparan sulfate sulfation pathway
A series of metabolic reactions which facilitate hyaluronan polysaccharide synthesis.
hyaluronan biosynthetic pathway
A metabolic pathway whereby type I LacNAc structures receive an N-acetylglucosamine residue in a β1-6 linkage via GCNT2 or GCNT3.
I branching biosynthetic pathway
A sequence of catabolic reactions whereby keratan sulfate is degraded in the cytoplasm.
keratan sulfate cytoplasmic degradation pathway
A series of catabolic reactions which degrade keratan sulfates.
keratan sulfate degradation pathway
A sequence of catabolic reactions whereby keratan sulfate is degraded in the lysosome.
keratan sulfate lysosomal degradation pathway
A series of metabolic reactions whereby keratan sulfates undergo repeated Type II LacNAc extension.
keratan sulfate polymerization pathway
A series of metabolic reactions where keratan sulfate receives sulfations on N-acetylglucosamine and galactose residues in LacNAc chains on either N-linked or O-linked glycans.
keratan sulfate sulfation pathway
A series of metabolic reactions whereby N-acetylgalactosamine is transferred onto N-acetylglucosamine.
N-N'-diacetyllactose diamine biosynthetic pathway
A series of metabolic reactions which synthesizes the Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B3GNT5, and B3GALNT1.
lacto-series core structure biosynthetic pathway
A process by which GNPTAB and GNPTG transfer N-acetylglucosamine to unprocessed N-linked glycan mannose branches to mark proteins for transport to the lysosome.
glycan-mediated lysosomal targeting
A series of catabolic reactions which degrade glycans in the lysosomal lumen.
lysosomal glycan degradation pathway
A series of metabolic reactions whereby molecular substituents such as sulfate, phosphate and acetyl groups are covalently attached to proteins or monosaccharides present on glycans.
glycan monosaccharide modification pathway
A sequence of reactions responsible for synthesizing substituents that modify monosaccharides, such as sulfate, phosphate, and ethanolamine.
monosaccharide-modifying substituent synthetic pathway
A process by which substrates required for the modification of monosaccharides on glycan structures are transported into the endoplasmic reticulum or Golgi.
monosaccharide modification transport pathway
N-linked glycosylation occurs on protein asparagine residues within an N-X-S/T sequon. N-linked glycans are characterized by having GlcNAc residues attached onto asparagine at the root of the glycan. N-linked glycans are synthesized in 3 stages: the dolichol pathway, processing, and optionally, branching.
n-linked glycan core structure biosynthetic pathway
A sequence of catabolic reactions whereby an n-linked glycan is degraded in the cytoplasm.
n-linked glycan cytoplasmic degradation pathway
A series of catabolic reactions which degrade N-linked glycans.
n-linked glycan degradation pathway
A sequence of catabolic reactions whereby an n-linked glycan is degraded in the cytoplasm.
n-linked glycan lysosomal degradation pathway
A series of metabolic reactions whereby the amine structure on glucosamine undergo sulfation to varying degrees.
heparan sulfate amine sulfation pathway
A series of metabolic reactions which synthesizes the Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)GlcCer structure through the successive action of B4GALT6, B3GNT5, and a myriad of B4GALTs.
neolacto-series core structure biosynthetic pathway
The addition or removal of acetyl groups onto Neu5Ac to form or degrade Neu5,9Ac.
n-acetylneuraminic acid acetylation and deacetylation pathway
A series of metabolic reactions whereby N-linked glycans receive N-acetylglucosamine residues through the action of MGAT enzymes.
Firstly, MGAT1 and MGAT2 transfer N-acetylglucosamine residues onto the a1-3 and a1-6 mannose arms of glycan structures which emerge from the processing pathway, respectively, and via the MGAT4a/b/c and MGAT5 enzymes.
n-linked glycan branching biosynthetic pathway
A series of metabolic reactions whereby the dolichol precursor structure is trimmed successively via glucosidases and mannosidases.
The Processing pathways begins with the removal α(1-2)Glc by MOGS from the nonreducing terminal end of the α(1-3)Man branch to produce Glc2Man9GlcNAc2. During this trimming process, glycoproteins containing a single α(1-3)Glc residue are recognized by the ER lectin chaperones, calreticulin (CRT) and calnexin (CNX). These chaperones are complexed with protein disulfide isomerase isoforms, and this aids the folding and maturation of glycoproteins. Upon transient release from the lectin chaperones, α-Glucosidase II clips the remaining Glc and the protein moves to the next steps of processing, provided it is well folded.
n-glycan trimming pathway
A sequence of metabolic reactions whereby monosaccharides are covalently attached to various nucleotides in the cytoplasm to form nucleotide sugar substrates for glycosylation.
nucleotide sugar biosynthetic pathway
A process by which nucleotide sugars synthesized in the cytoplasm are transported into the endoplasmic reticulum or Golgi to serve as substrates for glycosylation.
nucleotide sugar transport
A process by which nutrients are transported into the cytoplasm from outside the cell.
monosaccharide transport
A series of metabolic reactions which attach fucose to serine or threonine residues in EGF-like repeats ( CXXXX(S/T)C ), and subsequently extend them.
o-fucosylation type glycan biosynthetic pathway
A series of metabolic reactions which attach N-acetylgalactosamine onto serine or threonine residues of amino acids and create the core o-linked glycan structures.
o-n-acetylgalactosamine type glycan biosynthetic pathway
A metabolic pathway where glucose is attached onto serine or threonine residues on proteins.
o-linked glucose biosynthetic process
A metabolic process by which N-acetylglucosamine is attached to serine or threonine residues on nuclear cytoplasmic proteins.
EOGT-type o-linked glycan biosynthetic pathway
o-n-acetylglucosamine protein glycosylation pathway
A series of metabolic reactions whereby mannose is attached to serine or threonine residues of proteins and subsequent reactions create core o-linked mannose-type structures.
o-linked mannose biosynthetic pathway
A series of metabolic reactions whereby chondroitin, dermatan, and heparan sulfates are initiated.
o-linked xylose glycosaminoglycan core structure biosynthetic pathway
A series of metabolic reactions which transfer the first monosaccharides onto oxygen atoms of amino acids and the subsequent initiation of o-glycan classes.
o-linked glycan biosynthetic pathway
A sequence of catabolic reactions whereby an o-linked glycan is degraded in the cytoplasm.
o-linked glycan cytoplasmic degradation pathway
A series of catabolic reactions which degrade O-linked glycans.
o-linked glycan degradation pathway
A sequence of catabolic reactions whereby an o-linked glycan is degraded in the lysosome.
o-linked glycan lysosomal degradation pathway
Other breakdown processes related to glycosylation.
other complex carbohydrate degradation pathway
A process by which phosphoadenosine phosphosulfate (PAPS) is synthesized.
phosphoadenosine phosphosulfate synthetic pathway
The process by which PAPS is transported into the Golgi to be a substrate for glycan sulfation.
phosphoadenosine phosphosulfate transport
The series of metabolic reactions which add monosaccharides to o-linked fucose structure which was initiated by the POFUT1 glycoenzyme.@en
POFUT1-type o-linked fucose biosynthetic pathway
The series of metabolic reactions which add monosaccharides to o-linked fucose structure which was initiated by the POFUT2 glycoenzyme.@en
POFUT2-Type o-linked fucose biosynthetic pathway
A series of metabolic reactions whereby mannose is attached to serine or threonine residues in proteins, followed by N-acetylglucosamine residues which results in the formation ofCore M1 or Core M2 O-mannose structures.
POMGNT1-type o-mannose glycan biosynthetic pathway
A series of metabolic reactions whereby mannose is attached to serine or threonine residues on proteins and subsequently receives N-acetylglucosamine from the POMGNT2 enzyme, thus forming the Core M3 O-mannose structure.
POMGNT2-type o-mannose glycan biosynthetic pathway event
A sequence of metabolic reactions whereby mannose is attached to serine or threonie residues on proteins through the action of POMT enzymes.
POMT-type o-mannose glycan biosynthetic pathway
A sequence of metabolic or transitory events involved in the biosynthesis of glycans. This involves i. synthesis of nucleotide sugar substrates for glycosylation, ii. transport of nucleotide sugar substrates into the endoplasmic reticulum and Golgi, iii. biosynthesis of glycans, and iv. degradation of glycans.
glycosylation-related pathway
The process of the addition of sialic acid onto the non-reducing ends of o-linked fucose-type glycans.
terminal sialylation of o-linked fucose glycans biosynthetic pathway
A series of metabolic reactions whereby sulfate molecules are covalently attached to monosaccharides which constitute some o-linked glycan.
o-linked glycan sulfation biosynthetic pathway
A process whereby sulfate groups are transfered onto proteins as a post-translational modification.
protein sulfation process
A class describing glycoenzymes with unknown involvement in glycosylation. They are still under investigation or have been postulated to participate in pathways but lack experimental evidence.
putative or unknown glycosylation pathway
The process by which N-acetylgalactosamine is added to galactose in a b1-4 linkage by B4GALNT2.
Sda antigen biosynthetic pathway
The process of the addition of sialic acid onto the non-reducing ends of glycan structures.
terminal sialylation biosynthetic pathway
A process by which mannose is added onto serine or threonine residues on proteins through the action of TMTC1-4 proteins.
TMTC-type o-mannosylation of proteins
The process by which galactose residues present in galactosylceramides are sulfated.
terminal galactose sulfation pathway
A process by which molecules are transported from one cellular compartment to another.
glycan substrate transport pathway
A metabolic pathway whereby the disaccharide [Gal(β1-3)GalNAc] is synthesized on glycans.
type iii lactosamine biosynthetic pathway
A process by which the disaccharide [Gal(β1-4)GlcNAc] is synthesized on glycans.
type ii lactosamine biosynthetic pathway
A metabolic pathway whereby the disaccharide [Gal(β1-3)GlcNAc] is synthesized on glycans.
type i lactosamine biosynthetic pathway
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate n-acetylgalactosamine.
uridine-5'-diphosphate n-acetylgalactosamine synthetic pathway
A process by which UDP-N-acetylgalactosamine is transported from the cytoplasm to the Golgi.
Analagous GO biological process missing for this term.
uridine-5'-diphosphate n-acetylgalactosamine transport
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate galactose.
uridine-5'-diphosphate galactose synthetic pathway
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate glucuronic acid.
uridine-5'-diphosphate glucuronic acid synthetic pathway
A process by which UDP-glucuronic acid is transported from the cytoplasm to the Golgi.
Analagous GO biological process missing for this term.
uridine-5'-diphosphate glucuronic acid transport
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate n-acetylglucosamine.
uridine-5'-diphosphate n-acetylglucosamine synthetic pathway
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate glucose.
uridine-5'-diphosphate glucose synthetic pathway
A process by which UDP-glucose is transported from the cytoplasm to the endoplasmic reticulum.
Analagous GO biological process missing for this term.
uridine-5'-diphosphate glucose transport
A sequence of metabolic events responsible for the synthesis of uridine-5'-diphosphate xylose.
uridine-5'-diphosphate xylose synthetic pathway
The process of the addition of sialic acid onto the non-reducing ends of o-linked glycan structures.
terminal sialylation of o-linked glycans biosynthetic pathway
The process of the addition of sialic acid onto the non-reducing ends of n-linked glycan structures.
terminal sialylation of n-linked glycans biosynthetic pathway
The process of the addition of sialic acid onto the non-reducing ends of gangliosides.
terminal sialylation of gangliosides biosynthetic pathway
GlcA<3>6S(b1-3); <Gal(b1-3),GalNAc(b1-3)>GlcNAc(b1-?)
Man(a1-3)[@Man(a1-6)]Man(b1-4)
nGalNAc(a1-?)=1
A string which specifies restrictions as to what substrates are recognized by glycoenzymes, as well as by providing more structural context as to where reactions take place on a glycan. These strings use a combination of IUPAC symbols to depict monosaccharides and a set of symbols to restrict the glycan substrates of a glycoenzyme.
reaction constraint
A series of metabolic reactions whereby monosaccharides that are part of glycans receive a sulfate molecule
glycan monosaccharide sulfation pathway
Extracellular n-acetylglucosamine modification of EGF-like repeats on ceullar surface proteins.
o-n-acetylglucosamine EGF repeat
UDP-GlcNAc[Cytosol] -> UDP-GlcNAc[ER]
{!Glc(a1-3)}Glc(a1-3)Glc(a1-3)
{Glc1P<->Glc6P}
{Neu5Ac(a2-3)}Gal(b1-4)GlcNAc(b1-?)
{…GlcA(b1-3)→...IdoA(b1-3)}
A string that represents the glycan structure recognized by a glycoenzyme and its function to metabolize it into a product. These strings use a combination of IUPAC symbols to depict monosaccharides and reaction rule strings to describe addition, subtraction, substitution, reversible reactions, and transport processes.
reaction rule
The biosynthesis of type i lactosamine chains on o-GalNAc glycans.
type i lactosamine extension of o-n-acetylgalactossamine glycan biosynthetic pathway
The biosynthesis of type i lactosamine chains on n-linked glycans.
type i lactosamine extension of n-linked glycan biosynthetic pathway
The biosynthesis of type ii lactosamine chains on O-GalNAc glycans.
type ii lactosamine extension of o-n-acetylgalactosamine glycan biosynthetic pathway
The biosynthesis of type ii lactosamine chains on n-linked glycans.
type ii lactosamine extension of n-linked glycan biosynthetic pathway
A process by which galactose residues from collagen are removed.
collagen degradation pathway
A series of metabolic reactions whereby sulfate molecules are covalently attached to monosaccharides which constitute glycosaminoglycans.
glycosaminoglycan sulfation pathway
glycosylation-related pathway participant
glycan biosynthesis regulation participant
glycan-mediated lysosomal targeting participant
glycan biosynthetic pathway participant
glycan capping structure biosynthetic pathway participant
human natural killer 1 epitope biosynthetic pathway participant
n-acetylneuraminic acid acetylation and deacetylation pathway participant
Sda antigen biosynthetic pathway participant
terminal fucosylation biosynthetic pathway participant
abo blood group biosynthetic pathway participant
terminal sialylation biosynthetic pathway participant
glycan core structure biosynthetic pathway participant
c-linked mannose biosynthetic pathway participant
glycolipid core structure biosynthetic pathway participant
glycosphingolipid core structure biosynthetic pathway participant
galactosylceramide biosynthetic pathway participant
glucosylceramide biosynthetic pathway participant
ganglioside core structure biosynthetic pathway participant
globo-series core structure biosynthetic pathway participant
lacto-series core structure biosynthetic pathway participant
neolacto-series core structure biosynthetic pathway particiant
glycosylphosphatidylinositol anchor biosynthetic pathway participant
glycosaminoglycan core structure biosynthetic pathway participant
hyaluronan biosynthetic pathway participant
o-linked xylose glycosaminoglycan core structure biosynthetic pathway participant
chondroitin and dermatan sulfate core structure biosynthetic pathway participant
n-linked glycan core structure biosynthetic pathway participant
dolichol precursor biosynthetic pathway participant
n-glycan trimming pathway participant
n-linked glycan branching biosynthetic pathway participant
o-linked glycan biosynthetic pathway participant
collagen glycosylation pathway participant
o-fucosylation type glycan biosynthetic pathway participant
POFUT1-type o-linked fucose biosynthetic pathway participant
o-linked glucose biosynthetic pathway participant
POMT-type o-mannose glycan biosynthetic pathway participant
POMGNT1-type o-mannose glycan biosynthetic pathway participant
POMGNT2-type o-mannose glycan biosynthetic pathway participant
α-Dystroglycan biosynthetic pathway participant
TMTC-type o-mannosylation of proteins participant
o-n-acetylgalactosamine type glycan biosynthetic pathway participant
core 1 type o-N-acetylgalactosamine type glycan biosynthetic pathway participant
core 2 type o-N-acetylgalactosamine type glycan biosynthetic pathway participant
core 3 type o-N-acetylgalactosamine type glycan biosynthetic pathway participant
core 4 type o-N-acetylgalactosamine type glycan biosynthetic pathway participant
o-n-acetylglucosamine protein glycosylation pathway participant
glycan elongation and branching biosynthetic pathway participant
glycosaminoglycan polymerization pathway participant
chondroitin and dermatan sulfate polymerization pathway participant
heparan sulfate polymerization pathway participant
keratan sulfate polymerization pathway participant
I branching biosynthetic pathway participant
lactoamine biosynthetic pathway participant
type i lactosamine biosynthetic pathway participant
type ii lactosamine biosynthetic pathway participant
type iii lactosamine biosynthetic pathway participant
N-N'-diacetyllactose diamine biosynthetic pathway participant
glycan degradation pathway participant
cytoplasmic glycan degradation pathway participant
chondroitin sulfate cytoplasmic degradation pathway participant
dermatan sulfate cytoplasmic degradation pathway participant
glycosphingolipid cytosolic degradation pathway participant
heparan sulfate cytoplasmic degradation pathway participant
hyaluronic acid cytoplasmic degradation pathway participant
keratan sulfate cytoplasmic degradation pathway participant
n-linked glycan cytoplasmic degradation pathway participant
o-linked glycan cytoplasmic degradation pathway participant
extracellular glycan degradation pathway participant
dermatan sulfate extracellular degradation pathway participant
heparan sulfate extracellular degradation pathway participant
hyaluronic acid extracellular degradation pathway participant
glycosaminoglycan degradation pathway participant
chondroitin sulfate degradation pathway participant
dermatan sulfate degradation pathway participant
glycosaminoglycan lysosomal degradation pathway participant
heparan sulfate degradation pathway participant
hyaluronic acid degradation pathway participant
keratan sulfate degradation pathway participant
glycosphingolipid degradation pathway participant
lysosomal glycan degradation pathway participant
glycosaminoglycan lysosomal degradation pathway participant
chondroitin sulfate lysosomal degradation pathway participant
dermatan sulfate lysosomal degradation pathway participant
hyaluronic acid lysosomal degradation pathway participant
keratan sulfate lysosomal degradation pathway participant
glycosphingolipid lysosomal degradation pathway participant
heparan sulfate lysosome degradation pathway participant
n-linked glycan lysosomal degradation pathway participant
o-linked glycan lysosomal degradation pathwa participant
n-linked glycan degradation pathway participant
o-linked glycan degradation pathway participant
other complex carbohydrate degradation pathway participant
collagen degradation pathway participant
glycogen catabolic pathway participant
glycan molecular donor synthesis pathway participant
monosaccharide-modifying substituent synthetic pathway participant
phosphoadenosine phosphosulfate synthetic pathway participant
nucleotide sugar biosynthetic pathway participant
cytidine-5'-monophosphate n-acetylneuraminic acid synthetic pathway participant
guanosine-5'-diphosphate fucose synthetic pathway participant
guanosine-5'-diphosphate mannose synthetic pathway participant
uridine-5'-diphosphate galactose synthetic pathway participant
uridine-5'-diphosphate glucose synthetic pathway participant
uridine-5'-diphosphate glucuronic acid synthetic pathway participant
uridine-5'-diphosphate n-acetylglucosamine synthetic pathway participant
uridine-5'-diphosphate n-acetylgalactosamine synthetic pathway participant
uridine-5'-diphosphate xylose synthetic pathway participant
glycan monosaccharide modification pathway participant
glycan monosaccharide sulfation pathway participant
6-sulfated sialyl lewis x biosynthetic pathway participant
glycosaminoglycan sulfation pathway participant
chondroitin and dermatan sulfate sulfation pathway participant
heparan sulfate sulfation pathway participant
heparan sulfate amine sulfation pathway participant
keratan sulfate sulfation pathway participant
terminal galactose sulfation pathway participant
protein sulfation process participant
glycan substrate transport pathway participant
glycan donor transport pathway participant
monosaccharide modification transport pathway participant
phosphoadenosine phosphosulfate transport participant
nucleotide sugar transport participant
CMP-N-acetylneuraminate transmembrane transport participant
GDP-fucose import into Golgi lumen participant
guanosine-5'-diphosphate mannose transport participant
uridine-5'-diphosphate galactose transport participant
uridine-5'-diphosphate n-acetylglucosamine transport participant
uridine-5'-diphosphate xylose acid transport participant
uridine-5'-diphosphate glucose transport participant
uridine-5'-diphosphate glucuronic acid transport participant
uridine-5'-diphosphate n-acetylgalactosamine transport participant
monosaccharide transport participant
glucose import participant
glucose importer in response to insulin stimulus
glucose transport participant
putative or unknown glycosylation pathway member
xenobiotic glucuronidation pathway participant
terminal sialylation of o-linked glycans biosynthetic pathway participant
terminal sialylation of n-linked glycans biosynthetic pathway participant
terminal sialylation of gangliosides biosynthetic pathway participant
terminal sialylation of o-linked fucose glycans biosynthetic pathway participant
o-linked glycan sulfation biosynthetic pathway participant
POFUT2-Type o-linked fucose biosynthetic pathway participant
heparan sulfate core structure biosynthetic pathway participant
type i lactosamine extension of o-n-acetylgalactosamine glycan biosynthetic pathway participant
type i lactosamine extension of n-linked glycan biosynthetic pathway participant
type ii lactosamine extension of o-n-acetylgalactosamine glycan biosynthetic pathway participant
type ii lactosamine extension of n-linked glycan biosynthetic pathway participant
o-n-acetylglucosamine EGF repeat participant
2022-05-18T19:58:52Z
lactosamine biosynthetic pathway
https://www.ncbi.nlm.nih.gov/gene/727936
GXYLT2
https://www.ncbi.nlm.nih.gov/gene/729920
CRPPA
https://www.ncbi.nlm.nih.gov/gene/644974
ALG1L2
https://www.ncbi.nlm.nih.gov/gene/3038
HAS3
https://www.ncbi.nlm.nih.gov/gene/4126
MANBA
https://www.ncbi.nlm.nih.gov/gene/5352
PLOD2
https://www.ncbi.nlm.nih.gov/gene/4242
MFNG
https://www.ncbi.nlm.nih.gov/gene/4125
MAN2B1
https://www.ncbi.nlm.nih.gov/gene/8790
FPGT
https://www.ncbi.nlm.nih.gov/gene/9957
HS3ST1
https://www.ncbi.nlm.nih.gov/gene/8473
OGT
https://www.ncbi.nlm.nih.gov/gene/5373
PMM2
https://www.ncbi.nlm.nih.gov/gene/29906
ST8SIA5
https://www.ncbi.nlm.nih.gov/gene/51046
ST8SIA3
https://www.ncbi.nlm.nih.gov/gene/9061
PAPSS1
https://www.ncbi.nlm.nih.gov/gene/9334
B4GALT5
https://www.ncbi.nlm.nih.gov/gene/8733
GPAA1
https://www.ncbi.nlm.nih.gov/gene/11041
B4GAT1
https://www.ncbi.nlm.nih.gov/gene/9486
CHST10
https://www.ncbi.nlm.nih.gov/gene/8372
HYAL3
https://www.ncbi.nlm.nih.gov/gene/8707
B3GALT2
https://www.ncbi.nlm.nih.gov/gene/2137
EXTL3
https://www.ncbi.nlm.nih.gov/gene/8534
CHST1
https://www.ncbi.nlm.nih.gov/gene/9394
HS6ST1
https://www.ncbi.nlm.nih.gov/gene/10905
MAN1A2
https://www.ncbi.nlm.nih.gov/gene/10724
OGA
https://www.ncbi.nlm.nih.gov/gene/8460
TPST1
https://www.ncbi.nlm.nih.gov/gene/8703
B4GALT3
https://www.ncbi.nlm.nih.gov/gene/8702
B4GALT4
https://www.ncbi.nlm.nih.gov/gene/2762
GMDS
https://www.ncbi.nlm.nih.gov/gene/8985
PLOD3
https://www.ncbi.nlm.nih.gov/gene/54600
UGT1A9
https://www.ncbi.nlm.nih.gov/gene/7358
UGDH
https://www.ncbi.nlm.nih.gov/gene/8459
TPST2
https://www.ncbi.nlm.nih.gov/gene/8813
DPM1
https://www.ncbi.nlm.nih.gov/gene/8704
B4GALT2
https://www.ncbi.nlm.nih.gov/gene/9917
FAM20B
https://www.ncbi.nlm.nih.gov/gene/2218
FKTN
https://www.ncbi.nlm.nih.gov/gene/10720
UGT2B11
https://www.ncbi.nlm.nih.gov/gene/85365
ALG2
https://www.ncbi.nlm.nih.gov/gene/8706
B3GALNT1
https://www.ncbi.nlm.nih.gov/gene/7367
UGT2B17
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/26229
B3GAT3
https://www.ncbi.nlm.nih.gov/gene/8818
DPM2
https://www.ncbi.nlm.nih.gov/gene/9945
GFPT2
https://www.ncbi.nlm.nih.gov/gene/26035
GLCE
https://www.ncbi.nlm.nih.gov/gene/9060
PAPSS2
https://www.ncbi.nlm.nih.gov/gene/5238
PGM3
https://www.ncbi.nlm.nih.gov/gene/9245
GCNT3
https://www.ncbi.nlm.nih.gov/gene/23556
PIGN
https://www.ncbi.nlm.nih.gov/gene/9215
LARGE1
https://www.ncbi.nlm.nih.gov/gene/81031
SLC2A10
https://www.ncbi.nlm.nih.gov/gene/9348
NDST3
https://www.ncbi.nlm.nih.gov/gene/8705
B3GALT4
https://www.ncbi.nlm.nih.gov/gene/2629
GBA
https://www.ncbi.nlm.nih.gov/gene/2517
FUCA1
https://www.ncbi.nlm.nih.gov/gene/6184
RPN1
https://www.ncbi.nlm.nih.gov/gene/6185
RPN2
https://www.ncbi.nlm.nih.gov/gene/7363
UGT2B4
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/2717
GLA
https://www.ncbi.nlm.nih.gov/gene/2821
GPI
https://www.ncbi.nlm.nih.gov/gene/3073
HEXA
https://www.ncbi.nlm.nih.gov/gene/3074
HEXB
https://www.ncbi.nlm.nih.gov/gene/2592
GALT
https://www.ncbi.nlm.nih.gov/gene/2990
GUSB
https://www.ncbi.nlm.nih.gov/gene/10941
UGT2A1
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/574357
UGT2A2
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/2548
GAA
https://www.ncbi.nlm.nih.gov/gene/3309
HSPA5
https://www.ncbi.nlm.nih.gov/gene/6531
SLC2A1
https://www.ncbi.nlm.nih.gov/gene/6514
SLC2A2
https://www.ncbi.nlm.nih.gov/gene/6515
SLC2A3
https://www.ncbi.nlm.nih.gov/gene/3482
IGF2R
https://www.ncbi.nlm.nih.gov/gene/5589
PRKCSH
https://www.ncbi.nlm.nih.gov/gene/7184
HSP90B1
https://www.ncbi.nlm.nih.gov/gene/6517
SLC2A4
https://www.ncbi.nlm.nih.gov/gene/2683
B4GALT1
https://www.ncbi.nlm.nih.gov/gene/2799
GNS
https://www.ncbi.nlm.nih.gov/gene/411
ARSB
https://www.ncbi.nlm.nih.gov/gene/6480
ST6GAL1
https://www.ncbi.nlm.nih.gov/gene/2720
GLB1
https://www.ncbi.nlm.nih.gov/gene/28
ABO
https://www.ncbi.nlm.nih.gov/gene/7364
UGT2B7
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/4668
NAGA
https://www.ncbi.nlm.nih.gov/gene/54578
UGT1A6
https://www.ncbi.nlm.nih.gov/gene/3098
HK1
https://www.ncbi.nlm.nih.gov/gene/2523
FUT1
https://www.ncbi.nlm.nih.gov/gene/4074
M6PR
https://www.ncbi.nlm.nih.gov/gene/175
AGA
https://www.ncbi.nlm.nih.gov/gene/2525
FUT3
https://www.ncbi.nlm.nih.gov/gene/2526
FUT4
https://www.ncbi.nlm.nih.gov/gene/3423
IDS
https://www.ncbi.nlm.nih.gov/gene/54658
UGT1A1
https://www.ncbi.nlm.nih.gov/gene/54657
UGT1A4
https://www.ncbi.nlm.nih.gov/gene/6518
SLC2A5
https://www.ncbi.nlm.nih.gov/gene/4245
MGAT1
https://www.ncbi.nlm.nih.gov/gene/811
CALR
https://www.ncbi.nlm.nih.gov/gene/821
CANX
https://www.ncbi.nlm.nih.gov/gene/4121
MAN1A1
https://www.ncbi.nlm.nih.gov/gene/2588
GALNS
https://www.ncbi.nlm.nih.gov/gene/4351
MPI
https://www.ncbi.nlm.nih.gov/gene/3425
IDUA
https://www.ncbi.nlm.nih.gov/gene/54659
UGT1A3
https://www.ncbi.nlm.nih.gov/gene/54579
UGT1A5
https://www.ncbi.nlm.nih.gov/gene/2645
GCK
https://www.ncbi.nlm.nih.gov/gene/2538
G6PC1
https://www.ncbi.nlm.nih.gov/gene/7365
UGT2B10
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/5236
PGM1
https://www.ncbi.nlm.nih.gov/gene/5277
PIGA
https://www.ncbi.nlm.nih.gov/gene/6677
SPAM1
https://www.ncbi.nlm.nih.gov/gene/1650
DDOST
https://www.ncbi.nlm.nih.gov/gene/10007
GNPDA1
https://www.ncbi.nlm.nih.gov/gene/3703
STT3A
https://www.ncbi.nlm.nih.gov/gene/4122
MAN2A2
https://www.ncbi.nlm.nih.gov/gene/2584
GALK1
https://www.ncbi.nlm.nih.gov/gene/5973
RENBP
https://www.ncbi.nlm.nih.gov/gene/6448
SGSH
https://www.ncbi.nlm.nih.gov/gene/2528
FUT6
https://www.ncbi.nlm.nih.gov/gene/3099
HK2
https://www.ncbi.nlm.nih.gov/gene/3101
HK3
https://www.ncbi.nlm.nih.gov/gene/3340
NDST1
https://www.ncbi.nlm.nih.gov/gene/8509
NDST2
https://www.ncbi.nlm.nih.gov/gene/4669
NAGLU
https://www.ncbi.nlm.nih.gov/gene/2581
GALC
https://www.ncbi.nlm.nih.gov/gene/7366
UGT2B15
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/51227
PIGP
https://www.ncbi.nlm.nih.gov/gene/338596
ST8SIA6
https://www.ncbi.nlm.nih.gov/gene/1603
DAD1
https://www.ncbi.nlm.nih.gov/gene/7355
SLC35A2
https://www.ncbi.nlm.nih.gov/gene/10559
SLC35A1
https://www.ncbi.nlm.nih.gov/gene/2583
B4GALNT1
https://www.ncbi.nlm.nih.gov/gene/2585
GALK2
https://www.ncbi.nlm.nih.gov/gene/1486
CTBS
https://www.ncbi.nlm.nih.gov/gene/2650
GCNT1
https://www.ncbi.nlm.nih.gov/gene/5351
PLOD1
https://www.ncbi.nlm.nih.gov/gene/2673
GFPT1
https://www.ncbi.nlm.nih.gov/gene/5281
PIGF
https://www.ncbi.nlm.nih.gov/gene/4248
MGAT3
https://www.ncbi.nlm.nih.gov/gene/4249
MGAT5
https://www.ncbi.nlm.nih.gov/gene/4247
MGAT2
https://www.ncbi.nlm.nih.gov/gene/2590
GALNT2
https://www.ncbi.nlm.nih.gov/gene/2589
GALNT1
https://www.ncbi.nlm.nih.gov/gene/2524
FUT2
https://www.ncbi.nlm.nih.gov/gene/2527
FUT5
https://www.ncbi.nlm.nih.gov/gene/2529
FUT7
https://www.ncbi.nlm.nih.gov/gene/6482
ST3GAL1
https://www.ncbi.nlm.nih.gov/gene/6487
ST3GAL3
https://www.ncbi.nlm.nih.gov/gene/6484
ST3GAL4
https://www.ncbi.nlm.nih.gov/gene/3373
HYAL1
https://www.ncbi.nlm.nih.gov/gene/8692
HYAL2
https://www.ncbi.nlm.nih.gov/gene/10960
LMAN2
https://www.ncbi.nlm.nih.gov/gene/10956
OS9
https://www.ncbi.nlm.nih.gov/gene/7264
GFUS
https://www.ncbi.nlm.nih.gov/gene/7841
MOGS
https://www.ncbi.nlm.nih.gov/gene/2582
GALE
https://www.ncbi.nlm.nih.gov/gene/2591
GALNT3
https://www.ncbi.nlm.nih.gov/gene/5283
PIGH
https://www.ncbi.nlm.nih.gov/gene/23193
GANAB
https://www.ncbi.nlm.nih.gov/gene/6675
UAP1
https://www.ncbi.nlm.nih.gov/gene/2131
EXT1
https://www.ncbi.nlm.nih.gov/gene/4124
MAN2A1
https://www.ncbi.nlm.nih.gov/gene/7357
UGCG
https://www.ncbi.nlm.nih.gov/gene/6483
ST3GAL2
https://www.ncbi.nlm.nih.gov/gene/7360
UGP2
https://www.ncbi.nlm.nih.gov/gene/7368
UGT8
GALNT19
https://www.ncbi.nlm.nih.gov/gene/23553
HYAL4
https://www.ncbi.nlm.nih.gov/gene/23333
DPY19L1
https://www.ncbi.nlm.nih.gov/gene/440138
ALG11
https://www.ncbi.nlm.nih.gov/gene/80162
PGGHG
https://www.ncbi.nlm.nih.gov/gene/84992
PIGY
https://www.ncbi.nlm.nih.gov/gene/167127
UGT3A2
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/79158
GNPTAB
https://www.ncbi.nlm.nih.gov/gene/146664
MGAT5B
https://www.ncbi.nlm.nih.gov/gene/170384
FUT11
https://www.ncbi.nlm.nih.gov/gene/64409
GALNT17
https://www.ncbi.nlm.nih.gov/gene/283464
GXYLT1
https://www.ncbi.nlm.nih.gov/gene/65258
MPPE1
https://www.ncbi.nlm.nih.gov/gene/84920
ALG10
https://www.ncbi.nlm.nih.gov/gene/54872
PIGG
https://www.ncbi.nlm.nih.gov/gene/144245
ALG10B
https://www.ncbi.nlm.nih.gov/gene/285203
EOGT
https://www.ncbi.nlm.nih.gov/gene/79694
MANEA
https://www.ncbi.nlm.nih.gov/gene/84899
TMTC4
https://www.ncbi.nlm.nih.gov/gene/138050
HGSNAT
https://www.ncbi.nlm.nih.gov/gene/200810
ALG1L
https://www.ncbi.nlm.nih.gov/gene/283358
B4GALNT3
https://www.ncbi.nlm.nih.gov/gene/133688
UGT3A1
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/283417
DPY19L2
https://www.ncbi.nlm.nih.gov/gene/84750
FUT10
https://www.ncbi.nlm.nih.gov/gene/374378
GALNT18
https://www.ncbi.nlm.nih.gov/gene/79799
UGT2A3
Ted Groth
https://www.ncbi.nlm.nih.gov/gene/153642
ARSK
https://www.ncbi.nlm.nih.gov/gene/145173
B3GLCT
https://www.ncbi.nlm.nih.gov/gene/192134
B3GNT6
https://www.ncbi.nlm.nih.gov/gene/147991
DPY19L3
https://www.ncbi.nlm.nih.gov/gene/160418
TMTC3
https://www.ncbi.nlm.nih.gov/gene/337876
CHSY3
https://www.ncbi.nlm.nih.gov/gene/11046
SLC35D2
https://www.ncbi.nlm.nih.gov/gene/338707
B4GALNT4
83539
CHST9
https://www.ncbi.nlm.nih.gov/gene/51363
CHST15
https://www.ncbi.nlm.nih.gov/gene/9653
HS2ST1
https://www.ncbi.nlm.nih.gov/gene/9469
CHST3
https://www.ncbi.nlm.nih.gov/gene/286148
DPY19L4
https://www.ncbi.nlm.nih.gov/gene/143888
POGLUT3
https://www.ncbi.nlm.nih.gov/gene/117248
GALNT15
https://www.ncbi.nlm.nih.gov/gene/284098
PIGW
https://www.ncbi.nlm.nih.gov/gene/374907
B3GNT8
https://www.ncbi.nlm.nih.gov/gene/11227
GALNT5
https://www.ncbi.nlm.nih.gov/gene/51809
GALNT7
https://www.ncbi.nlm.nih.gov/gene/55568
GALNT10
https://www.ncbi.nlm.nih.gov/gene/80235
PIGZ
https://www.ncbi.nlm.nih.gov/gene/22856
CHSY1
https://www.ncbi.nlm.nih.gov/gene/64131
XYLT1
https://www.ncbi.nlm.nih.gov/gene/114805
GALNT13
https://www.ncbi.nlm.nih.gov/gene/83857
TMTC1
https://www.ncbi.nlm.nih.gov/gene/55959
SULF2
https://www.ncbi.nlm.nih.gov/gene/23213
SULF1
https://www.ncbi.nlm.nih.gov/gene/54431
DNAJC10
https://www.ncbi.nlm.nih.gov/gene/79695
GALNT12
https://www.ncbi.nlm.nih.gov/gene/23127
COLGALT2
https://www.ncbi.nlm.nih.gov/gene/79586
CHPF
https://www.ncbi.nlm.nih.gov/gene/266722
HS6ST3
https://www.ncbi.nlm.nih.gov/gene/222537
HS3ST5
https://www.ncbi.nlm.nih.gov/gene/92126
DSEL
https://www.ncbi.nlm.nih.gov/gene/2651
GCNT2
https://www.ncbi.nlm.nih.gov/gene/197258
FCSK
https://www.ncbi.nlm.nih.gov/gene/160335
TMTC2
https://www.ncbi.nlm.nih.gov/gene/120071
LARGE2
https://www.ncbi.nlm.nih.gov/gene/57452
GALNT16
https://www.ncbi.nlm.nih.gov/gene/8693
GALNT4
https://www.ncbi.nlm.nih.gov/gene/26301
GBGT1
https://www.ncbi.nlm.nih.gov/gene/55454
CSGALNACT2
https://www.ncbi.nlm.nih.gov/gene/84892
POMGNT2
https://www.ncbi.nlm.nih.gov/gene/152002
XXYLT1
https://www.ncbi.nlm.nih.gov/gene/79709
COLGALT1
https://www.ncbi.nlm.nih.gov/gene/56983
POGLUT1
https://www.ncbi.nlm.nih.gov/gene/80146
UXS1
https://www.ncbi.nlm.nih.gov/gene/10164
CHST4
https://www.ncbi.nlm.nih.gov/gene/113189
CHST14
https://www.ncbi.nlm.nih.gov/gene/11226
GALNT6
https://www.ncbi.nlm.nih.gov/gene/148798
B3GALNT2
https://www.ncbi.nlm.nih.gov/gene/63917
GALNT11
https://www.ncbi.nlm.nih.gov/gene/256435
ST6GALNAC3
https://www.ncbi.nlm.nih.gov/gene/3955
LFNG
https://www.ncbi.nlm.nih.gov/gene/166012
CHST13
https://www.ncbi.nlm.nih.gov/gene/64772
ENGASE
https://www.ncbi.nlm.nih.gov/gene/93101
B3GNT7
https://www.ncbi.nlm.nih.gov/gene/55907
CMAS
https://www.ncbi.nlm.nih.gov/gene/124872
B4GALNT2
https://www.ncbi.nlm.nih.gov/gene/347734
SLC35B2
https://www.ncbi.nlm.nih.gov/gene/54965
PIGX
https://www.ncbi.nlm.nih.gov/gene/201595
STT3B
https://www.ncbi.nlm.nih.gov/gene/154091
SLC2A12
https://www.ncbi.nlm.nih.gov/gene/132789
GNPDA2
https://www.ncbi.nlm.nih.gov/gene/55790
CSGALNACT1
https://www.ncbi.nlm.nih.gov/gene/92370
PXYLP1
https://www.ncbi.nlm.nih.gov/gene/84720
PIGO
https://www.ncbi.nlm.nih.gov/gene/2595
GANC
https://www.ncbi.nlm.nih.gov/gene/60495
HPSE2
https://www.ncbi.nlm.nih.gov/gene/129807
NEU4
https://www.ncbi.nlm.nih.gov/gene/55624
POMGNT1
https://www.ncbi.nlm.nih.gov/gene/6489
ST8SIA1
https://www.ncbi.nlm.nih.gov/gene/8128
ST8SIA2
https://www.ncbi.nlm.nih.gov/gene/7903
ST8SIA4
https://www.ncbi.nlm.nih.gov/gene/9488
PIGB
https://www.ncbi.nlm.nih.gov/gene/5279
PIGC
https://www.ncbi.nlm.nih.gov/gene/9695
EDEM1
https://www.ncbi.nlm.nih.gov/gene/10026
PIGK
https://www.ncbi.nlm.nih.gov/gene/10195
ALG3
https://www.ncbi.nlm.nih.gov/gene/3037
HAS2
https://www.ncbi.nlm.nih.gov/gene/3036
HAS1
https://www.ncbi.nlm.nih.gov/gene/5372
PMM1
https://www.ncbi.nlm.nih.gov/gene/2134
EXTL1
https://www.ncbi.nlm.nih.gov/gene/2132
EXT2
https://www.ncbi.nlm.nih.gov/gene/51604
PIGT
https://www.ncbi.nlm.nih.gov/gene/84912
SLC35B4
https://www.ncbi.nlm.nih.gov/gene/30815
ST6GALNAC6
https://www.ncbi.nlm.nih.gov/gene/89792
GAL3ST3
https://www.ncbi.nlm.nih.gov/gene/55343
SLC35C1
https://www.ncbi.nlm.nih.gov/gene/27248
ERLEC1
https://www.ncbi.nlm.nih.gov/gene/22901
ARSG
https://www.ncbi.nlm.nih.gov/gene/64841
GNPNAT1
https://www.ncbi.nlm.nih.gov/gene/29071
C1GALT1C1
https://www.ncbi.nlm.nih.gov/gene/199857
ALG14
https://www.ncbi.nlm.nih.gov/gene/79623
GALNT14
https://www.ncbi.nlm.nih.gov/gene/55276
PGM2
https://www.ncbi.nlm.nih.gov/gene/29926
GMPPA
https://www.ncbi.nlm.nih.gov/gene/84620
ST6GAL2
https://www.ncbi.nlm.nih.gov/gene/126792
B3GALT6
https://www.ncbi.nlm.nih.gov/gene/90161
HS6ST2
https://www.ncbi.nlm.nih.gov/gene/64921
CASD1
https://www.ncbi.nlm.nih.gov/gene/64711
HS3ST6
https://www.ncbi.nlm.nih.gov/gene/79690
GAL3ST4
https://www.ncbi.nlm.nih.gov/gene/94005
PIGS
https://www.ncbi.nlm.nih.gov/gene/4758
NEU1
https://www.ncbi.nlm.nih.gov/gene/9514
GAL3ST1
https://www.ncbi.nlm.nih.gov/gene/9091
PIGQ
https://www.ncbi.nlm.nih.gov/gene/84302
PGAP4
https://www.ncbi.nlm.nih.gov/gene/56052
ALG1
https://www.ncbi.nlm.nih.gov/gene/2519
FUCA2
https://www.ncbi.nlm.nih.gov/gene/79087
ALG12
https://www.ncbi.nlm.nih.gov/gene/55741
EDEM2
https://www.ncbi.nlm.nih.gov/gene/81849
ST6GALNAC5
https://www.ncbi.nlm.nih.gov/gene/79053
ALG8
https://www.ncbi.nlm.nih.gov/gene/54490
UGT2B28
https://www.ncbi.nlm.nih.gov/gene/2530
FUT8
https://www.ncbi.nlm.nih.gov/gene/84002
B3GNT5
https://www.ncbi.nlm.nih.gov/gene/80267
EDEM3
https://www.ncbi.nlm.nih.gov/gene/79369
B3GNT4
https://www.ncbi.nlm.nih.gov/gene/23563
CHST5
https://www.ncbi.nlm.nih.gov/gene/4166
CHST6
https://www.ncbi.nlm.nih.gov/gene/64132
XYLT2
https://www.ncbi.nlm.nih.gov/gene/51000
SLC35B3
https://www.ncbi.nlm.nih.gov/gene/57733
GBA3
https://www.ncbi.nlm.nih.gov/gene/64377
CHST8
https://www.ncbi.nlm.nih.gov/gene/1798
DPAGT1
https://www.ncbi.nlm.nih.gov/gene/64090
GAL3ST2
https://www.ncbi.nlm.nih.gov/gene/64579
NDST4
https://www.ncbi.nlm.nih.gov/gene/93183
PIGM
https://www.ncbi.nlm.nih.gov/gene/23509
POFUT1
https://www.ncbi.nlm.nih.gov/gene/128869
PIGU
https://www.ncbi.nlm.nih.gov/gene/27090
ST6GALNAC4
https://www.ncbi.nlm.nih.gov/gene/84197
POMK
https://www.ncbi.nlm.nih.gov/gene/79796
ALG9
https://www.ncbi.nlm.nih.gov/gene/79147
FKRP
https://www.ncbi.nlm.nih.gov/gene/54414
SIAE
https://www.ncbi.nlm.nih.gov/gene/54577
UGT1A7
https://www.ncbi.nlm.nih.gov/gene/54575
UGT1A10
https://www.ncbi.nlm.nih.gov/gene/54576
UGT1A8
https://www.ncbi.nlm.nih.gov/gene/57704
GBA2
https://www.ncbi.nlm.nih.gov/gene/50614
GALNT9
https://www.ncbi.nlm.nih.gov/gene/79070
POGLUT2
https://www.ncbi.nlm.nih.gov/gene/79868
ALG13
https://www.ncbi.nlm.nih.gov/gene/53947
A4GALT
https://www.ncbi.nlm.nih.gov/gene/50515
CHST11
https://www.ncbi.nlm.nih.gov/gene/135152
B3GAT2
https://www.ncbi.nlm.nih.gov/gene/57134
MAN1C1
https://www.ncbi.nlm.nih.gov/gene/54187
NANS
https://www.ncbi.nlm.nih.gov/gene/55501
CHST12
https://www.ncbi.nlm.nih.gov/gene/56931
C1GALT1
https://www.ncbi.nlm.nih.gov/gene/56548
CHST7
https://www.ncbi.nlm.nih.gov/gene/55808
ST6GALNAC1
https://www.ncbi.nlm.nih.gov/gene/4123
MAN2C1
https://www.ncbi.nlm.nih.gov/gene/23169
SLC35D1
https://www.ncbi.nlm.nih.gov/gene/55650
PIGV
https://www.ncbi.nlm.nih.gov/gene/26290
GALNT8
https://www.ncbi.nlm.nih.gov/gene/29988
SLC2A8
https://www.ncbi.nlm.nih.gov/gene/10678
B3GNT2
https://www.ncbi.nlm.nih.gov/gene/55757
UGGT2
https://www.ncbi.nlm.nih.gov/gene/56886
UGGT1
https://www.ncbi.nlm.nih.gov/gene/51301
GCNT4
https://www.ncbi.nlm.nih.gov/gene/54480
CHPF2
https://www.ncbi.nlm.nih.gov/gene/27087
B3GAT1
https://www.ncbi.nlm.nih.gov/gene/54344
DPM3
https://www.ncbi.nlm.nih.gov/gene/25834
MGAT4C
https://www.ncbi.nlm.nih.gov/gene/2135
EXTL2
https://www.ncbi.nlm.nih.gov/gene/51726
DNAJB11
https://www.ncbi.nlm.nih.gov/gene/6400
SEL1L
https://www.ncbi.nlm.nih.gov/gene/11285
B4GALT7
https://www.ncbi.nlm.nih.gov/gene/9331
B4GALT6
https://www.ncbi.nlm.nih.gov/gene/23670
CEMIP2
https://www.ncbi.nlm.nih.gov/gene/10610
ST6GALNAC2
https://www.ncbi.nlm.nih.gov/gene/55577
NAGK
https://www.ncbi.nlm.nih.gov/gene/84572
GNPTG
https://www.ncbi.nlm.nih.gov/gene/51172
NAGPA
https://www.ncbi.nlm.nih.gov/gene/11253
MAN1B1
https://www.ncbi.nlm.nih.gov/gene/29954
POMT2
https://www.ncbi.nlm.nih.gov/gene/29940
DSE
https://www.ncbi.nlm.nih.gov/gene/11320
MGAT4A
https://www.ncbi.nlm.nih.gov/gene/51146
A4GNT
https://www.ncbi.nlm.nih.gov/gene/8869
ST3GAL5
https://www.ncbi.nlm.nih.gov/gene/10825
NEU3
https://www.ncbi.nlm.nih.gov/gene/11282
MGAT4B
https://www.ncbi.nlm.nih.gov/gene/10020
GNE
https://www.ncbi.nlm.nih.gov/gene/10690
FUT9
https://www.ncbi.nlm.nih.gov/gene/10855
HPSE
https://www.ncbi.nlm.nih.gov/gene/10402
ST3GAL6
https://www.ncbi.nlm.nih.gov/gene/9956
HS3ST2
https://www.ncbi.nlm.nih.gov/gene/10331
B3GNT3
https://www.ncbi.nlm.nih.gov/gene/10329
RXYLT1
https://www.ncbi.nlm.nih.gov/gene/9487
PIGL
https://www.ncbi.nlm.nih.gov/gene/10090
UST
https://www.ncbi.nlm.nih.gov/gene/10317
B3GALT5
https://www.ncbi.nlm.nih.gov/gene/23443
SLC35A3
https://www.ncbi.nlm.nih.gov/gene/23324
MAN2B2
https://www.ncbi.nlm.nih.gov/gene/23275
POFUT2
https://www.ncbi.nlm.nih.gov/gene/51005
AMDHD2
https://www.ncbi.nlm.nih.gov/gene/4759
NEU2
https://www.ncbi.nlm.nih.gov/gene/8418
CMAHP
https://www.ncbi.nlm.nih.gov/gene/9435
CHST2
https://www.ncbi.nlm.nih.gov/gene/10525
HYOU1
https://www.ncbi.nlm.nih.gov/gene/29925
GMPPB
https://www.ncbi.nlm.nih.gov/gene/8708
B3GALT1
https://www.ncbi.nlm.nih.gov/gene/5986
RFNG
https://www.ncbi.nlm.nih.gov/gene/9951
HS3ST4
https://www.ncbi.nlm.nih.gov/gene/9953
HS3ST3B1
https://www.ncbi.nlm.nih.gov/gene/9955
HS3ST3A1
https://www.ncbi.nlm.nih.gov/gene/29929
ALG6
https://www.ncbi.nlm.nih.gov/gene/29880
ALG5
https://www.ncbi.nlm.nih.gov/gene/10585
POMT1
https://www.ncbi.nlm.nih.gov/gene/127550
A3GALT2
Gal{1P}
GALK1-mediated galactose phosphorylation reaction rule
{GlcNAc(a1-?)}Ser/Thr[EGF]
EOGT-mediated n-acetylglucosaminyltransferase activity upon serine or threonie residues part of an EGF repeat reaction rule
{Glc(b1-?)}Ser[EGF]
POGLUT-mediated glucosyltransferase activity on serine present in EGF repeats reaction rule
{Xyl(a1-3)}Glc(b1-?)Ser[EGF]
GXYLT1/2-mediated xylosyltransferase activity reaction rule
{Xyl(a1-3)}Xyl(a1-3)Glc(b1-?)Ser[EGF]
XXYLT1-mediated xylosyltransferase activity reaction rule
{GlcNAc6P->GlcN6P}
AMDHD2-mediated deacetylation reaction rule
{Man(??-?)}WXXW
DPY19L-mediated c-mannose transfer reaction rule
{Man(a1-1)}Ser/Thr[Cad]
TMTC-mediated o-mannose transfer reaction rule
{Fuc(a1-?)}Ser/Thr[EGF]
POFUT1-mediated fucosyltransferase activity onto EGF-like repeat reaction rule
{Fuc(a1-?)}Ser/Thr[TSR]
POFUT2-mediated fucosyltransferase activity on TSR repeats reaction rule
{Gal1P->UDP-Gal}
GALT-mediated UDP-galactose synthetic activity reaction rule
{GlcNAc(b1-3)}Fuc(a1-?)Ser/Thr[EGF]
LFNG/MFNG/RFNG-mediated n-acetylglucosaminyltransferase activity reaction rule
{Glc(b1-3)}Fuc(a1-?)Ser/Thr[TSR]
B3GLCT-mediated glucosyltransferase activity onto o-linked fucose residues present in TSR repeats reaction rule
{Lys->5-hydroxy-L-lysyl}[COL]
PLOD1/2-mediated 5-hydroxy-l-lysyl group synthesis reaction rule
{Lys->5-hydroxy-L-lysyl}[COL]|{Glc(a1-2)}Gal(b1-?)5-hydroxy-L-lysyl[COL]
PLOD3-mediated 5-hydroxy-L-lysyl and glucosyltransferase activity reaction rule
{Gal(b1-?)}5-hydroxy-L-lysyl[COL]
COLGALT1/2-mediated galactosyltransferase activity on collagen reaction rule
GalNAc(b1-3)GlcNAc(b1-4)Man{6P}(a1-?)Ser/Thr[Dystro]
POMK-mediated mannose phosphorylation activity reaction rule
{Glc1P->UDP-Glc}
UGP2-mediated UDP-glucose synthesis reaction rule
{Man(a1-?)}Ser/Thr<[Dystro]>
POMT1/2-mediated o-mannose transfer reaction rule
{GlcNAc(b1-2)}Man(a1-?)Ser/Thr
POMGNT1-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-4)}Man(a1-?)Ser/Thr[Dystro]
POMGNT2-mediated n-acetylglucosaminyltransferase activity reaction rule
{Ribitol(P5-3)}GalNAc(b1-3)...Man6P(a1-?)Ser/Thr[Dystro]
FKTN-mediated ribitol transfer activity reaction rule
{Ribitol(P5-1)}Ribitol(P5-3)...Man6P(a1-?)Ser/Thr[Dystro]
FKRP-mediated transfer of ribitol activity reaction rule
GlcNAc(b1-2){[GlcNAc(b1-6)]}Man(a1-?)Ser/Thr|GlcNAc(b1-2){[GlcNAc(b1-6)]}Man(a1-6)
MGAT5B-mediated β1-6 n-acetyglucosaminyltransferase activity reaction rule
{GalNAc(b1-3)}GlcNAc(b1-?)|{GalNAc(b1-3)}GlcNAc(b1-4)Man(a1-?)Ser/Thr[Dystro]
B3GALNT2-mediated n-acetylgalactosaminyltransferase activity reaction rule
{Xyl(a1-3)}GlcA(b1-4)Xyl(b1-4)...Man6P(a1-?)Ser/Thr[Dystro]|{GlcA(b1-3)}Xyl(a1-3)...Man6P(a1-?)Ser/Thr[Dystro]|{Xyl(a1-3)}GlcA(b1-3)...Man6P(a1-?)Ser/Thr[Dystro]
LARGE1/2-mediated xylosyltransferase activity reaction rule
{UDP-Glc->UDP-GlcA}
UGDH-mediated conversion of UDP-glucose to UDP-glucuronic acid reaction rule
{Xyl(b1-4)}Ribitol(P5-1)...Man6P(a1-?)Ser/Thr[Dystro]
RXYLT1-mediated xylosyltransferase activity reaction rule
{GlcA(b1-4)}Xyl(b1-4)Ribitol(P5-1)...Man6P(a1-?)Ser/Thr[Dystro]
B4GAT1-mediated glucuronyltransferase activity reaction rule
{Ribitol5P->CMP-Ribitol}
CRPPA-mediated CPM-ribitol synthesis reaction rule
{GlcNAc(a1-6)}PI
PIGA-mediated n-acetylglucosaminyltransferase activity reaction rule
GlcN{!Ac}(a1-6)PI
PIGL-mediated deacetylation reaction rule
GlcN{[ancyl]}(a1-6)PI
PIGW-mediated ancyl transfer activity reaction rule
{Man(a1-4)}GlcN(a1-6)(ancyl)PI
PIGM-mediated mannosyltransferase activity reaction rule
{Man(a1-6)}Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGV-mediated mannosyltransferase activity reaction rule
Man(a1-6){[2EtNP]}Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGN-mediated ethanolamine transferase activity reaction rule
{Man(a1-2)}Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGB-mediated mannosyltransferase activity reaction rule
{UDP-GlcA->UDP-Xyl}
UXS1-mediated conversion of UDP-glucuronic acid to UPD-xylose reaction rule
{6EtNP}Man(a1-2)Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGO-mediated ethanolamine transfer reaction rule
6EtNPMan(a1-2){[6EtNP]}Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGG-mediated mannosyltransferase activity reaction rule
6EtNP{[Man(a1-2)]}Man(a1-2)[6EtNP]Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGZ-mediated mannosyltransferase activity reaction rule
{[anchored-protein]}6EtNP<[Man(a1-2)]>Man(a1-2)[6EtNP]Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
PIGK/GPAA1-mediated transaminic activity reaction rule
[anchored-protein]6EtNP<[Man(a1-2)]>Man(a1-2){![6EtNP]}Man(a1-6)[2EtNP]Man(a1-4)GlcN(a1-6)(ancyl)PI
MMPE1 removal of ethanolamine reaction rule
[anchored-protein]6EtNP<[Man(a1-2)]>Man(a1-2)Man(a1-6)[2EtNP]{[GalNAc(b1-4)]}Man(a1-4)GlcN(a1-6)(ancyl)PI
PGAP4-mediated GalNAc branching reaction rule
{Fuc(a1-2)}Gal(b1-?)GalNAc(b1-?)|{Fuc(a1-2)}Gal(b1-?)GlcNAc(b1-?)
α1-2 terminal fucosyltransferase activity reaction rule
...Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)|...Gal(b1-3){[Fuc(a1-4)]}GlcNAc(b1-?)|Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)|Gal(b1-3){[Fuc(a1-4)]}GlcNAc(b1-?)
bifunctional α1-3 and α1-4 terminal fucosyltransferase activity reaction rule
Glc{!6P}|Fruc{!6P}|Man{!6P}
G6PC1-mediated phosphatase activity reaction rule
...Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)
FUT4 terminal fucosylation activity reaction rule
Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)|Neu5Ac(a2-3)Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)
FUT6-mediated terminal fucosyltransferase activity reaction rule
Neu5Ac(a2-3)Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)
FUT7-mediated terminal fucosyltransferase activity reaction rule
Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)|...GlcNAc(b1-3)Gal(b1-4){[Fuc(a1-3)]}GlcNAc(b1-?)
FUT9-mediated terminal fucosyltransferase activity reaction rule
{Glc(b1-?)}Cer
UGCG-mediated glucosyltransferase activity onto ceramide reaction rule
Fuc(a1-2){[GalNAc(a1-3)]}Gal(b1-?)|Fuc(a1-2){[Gal(a1-3)]}Gal(b1-?)
ABO blood group synthesis reaction rule
{GalNAc(b1-3)}Gal(a1-4)Gal(b1-4)Glc(b1-?)Cer
B3GALNT1-mediated n-acetylgalactosaminyltransferase activity reaction rule
{GalNAc(b1-4)}Gal(b1-4)Glc(b1-?)Cer|Neu5Ac(a2-3){[GalNAc(b1-4)]}Gal(b1-4)Glc(b1-?)Cer|...Neu5Ac(a2-3){[GalNAc(b1-4)]}Gal(b1-4)Glc(b1-?)Cer
B4GALNT1-mediated n-acetylgalactosaminyltransferase activity reaction rule
Neu5Ac(a2-3){[GalNAc(b1-4)]}Gal(b1-4)GlcNAc|Neu5Ac(a2-3){[GalNAc(b1-4)]}Gal(b1-3)GlcNAc
B4GALNT2-mediated n-acetylgalactosamine activity reaction rule
{GlcN6P->GlcNAc6P}
GNPNAT1-mediated glucosamine-6-phosphate to n-acetylglucosamine-6-phosphate activity reaction rule
{GalNAc(b1-4)}GlcNAc(b1-?)
B4GALNT13/4-mediated n-acetylgalactosaminyltransferase activity reaction rule
{GalNAc(b1-4)}GlcA(b1-3)GalNAc(b1-4)|{GlcA(b1-3)}GalNAc(b1-4)GlcA(b1-3)
CHSY1/3 and CHPF-mediated n-acetylgalactosaminyltransferase activity reaction rule
{GalNAc(b1-4)}GlcA(b1-3)Gal(b1-3)Gal(b1-4)
CSGALNACT1-mediated n-acetylgalactosaminyltransferase activity reaction rule
{GalNAc(b1-4)}GlcA(b1-3)Gal(b1-3)Gal(b1-4)|{GalNAc(b1-4)}GlcA(b1-3)GalNAc(b1-4)
CSGALNACT2-mediated n-acetylgalactosaminyltransferase activity reaction rule
{GlcA(b1-3)}GalNAc(b1-4)GlcA(b1-3)
CHPF2-mediated glucuronic acid transfer reaction rule
...GlcA(b1-3)GalNAc{6S}(b1-4)GlcA|Neu5Ac(a2-3)Gal{6S}(b1-4)GlcNAc(b1-3)|...Gal{6S}(b1-4)GlcNAc6S(b1-3)
CHST3 sulfation reaction rule
...GlcA(b1-3)GalNAc{6S}(b1-4)
CHST7 sulfation reaction rule
{UDP-GlcNAc->ManNAc}|ManNAc{6P}
GNE-mediated UDP-n-acetylglucosamine to n-acetylmannosamine conversion or n-acetylmannoseamine phosphorylation reaction rule
...GlcA(b1-3)GalNAc{4S}(b1-4)|GalNAc{4S}(b1-4)GlcA(b1-3)
CHST11 and CHST13 sulfation reaction rule
...GlcA(b1-3)GalNAc{4S}(b1-4)|...IdoA(b1-3)GalNAc{4S}(b1-4)
CHST12 sulfation reaction rule
...IdoA(a1-3)GalNAc{4S}(b1-4)|...IdoA2S(a1-3)GalNAc{4S}(b1-4)
CHST14 sulfation reaction rule
...GlcA(b1-3)GalNAc{4,}6S(b1-4)|...IdoA(a1-3)GalNAc{4,}6S(b1-4)
CHST15 sulfation reaction rule
...{GlcA(b1-3)->IdoA(b1-3)}GalNAc(b1-4)
chondroitin and dermatan sulfate GlcA to IdoA epimerization reaction rule
GlcA{2S}(b1-3)GalNAc|IdoA{2S}(a1-3)GalNAc
UST-mediated sulfotransferase activity reaction rule
{GlcNAc(a1-?)}Ser/Thr
OGT-mediated n-acetylglucosaminyltransferase activity on serine or threonine residues reaction rule
{!GlcNAc(a1-?)}Ser/Thr
OGA-mediated o-linked n-acetylglucosaminidic activity reaction rule
{GlcN6P->Fruc6P}
glucosamine-6-phosphate to fructose-6-phosphate activity reaction rule
{GlcNAc(b1-4)}GlcA(b1-3)|{GlcA(b1-3)}GlcNAc(b1-4)
hyaluronan synthesis reaction rule
{Xyl(b1-?)}Ser
XYLT1/2-mediated xylosyltransferase activity on serine residues reaction rule
{Gal(b1-4)}Xyl(b1-?)Ser
B4GALT7-mediated galactosyltransferase activity reaction rule
Gal(b1-4)Xyl{2P}(b1-?)Ser
FAM20B-mediated xylose phosphorylation activity reaction rule
{Gal(b1-3)}Gal(b1-4)Xyl<2P>(b1-?)Ser
B3GALT6-mediated galactosyltransferase activity reaction rule
{GlcA(b1-3)}Gal(b1-3)Gal(b1-4)Xyl<2P>(b1-?)
B3GAT3-mediated glucoronyltransferase activity reaction rule
{GlcNAc(a1-4)}Gal(b1-3)GalNAc|{GlcNAc(a1-4)}Gal(b1-4)GlcNAc
A4GNT2-mediated n-acetylglucosaminyltransferase activity reaction rule
GalNAc{1P}
GALK2-mediated galactose phosphorylation activity reaction rule
{GlcNAc(b1-3)}Gal(b1-4)GlcNAc(b1-?)
β1-3 n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-3)}Gal(b1-3)GalNAc(a1-?)
B3GNT3-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-3)}Gal(b1-4)Glc(b1-?)Cer
B3GNT5-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-3)}GalNAc(a1-?)Ser/Thr
B3GNT6-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-3)}Gal(b1-4)GlcNAc(b1-?)|{GlcNAc(b1-3)}Gal(b1-4)GlcNAc6S(b1-?)
B3GNT7-mediated n-acetylglucosaminyltransferase activity reaction rule
Gal(b1-3){[GlcNAc(b1-6)]}GalNAc(a1-?)Ser/Thr
GCNT1/4-mediated n-acetylgalactosamine transferase activity reaction rule
...GlcNAc(b1-3){[GlcNAc(b1-6)]}Gal(b1-4)GlcNAc(b1-?)
GCNT2-mediated I-branching extension reaction rule
GlcNAc(b1-3){[GlcNAc(b1-6)]}GalNAc(a1-?)Ser/Thr|Gal(b1-3){[GlcNAc(b1-6)]}GalNAc(a1-?)Ser/Thr|...GlcNAc(b1-3){[GlcNAc(b1-6)]}Gal(b1-4)GlcNAc(b1-?)
GCNT3-mediated n-acetylglucosaminyltransferase activity reaction rule
{Man6P<->Fruc6P}
MPI-mediated mannose-6-phosphate to fructose-6-phosphate reaction rule
{GlcA(b1-4)}GlcNAc(a1-4)GlcA(b1-3)|{GlcNAc(a1-4)}GlcA(b1-4)GlcNAc(a1-4)
EXT1/2-mediated glucuronyltransferase activity reaction rule
{GlcNAc(a1-4)}GlcA(b1-4)GlcNAc(a1-4)
EXTL1-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(a1-4)}GlcA(b1-3)Gal(b1-3)Gal(b1-4)Xyl<2P>|{GlcNAc(a1-4)}GlcA(b1-4)GlcNAc(a1-4)
EXTL2/3-mediated n-acetylglucosaminyltransferase activity reaction rule
...GlcA(b1-4){GlcNAc(a1-4)->GlcNS(a1-4)}
NDST-mediated GlcNAc-to-GlcNS reaction rule
{GlcNAc<->ManNAc}
RENBP-mediated n-acetylglucosamine to n-acetylmannosamine conversion reaction rule
...{GlcA(a1-4)->IdoA(a1-4)}GlcNS
GLCE-mediated GlcA to IdoA isomerization on heparan sulfate reaction rule
GlcA{2S}(b1-3)GalNS(b1-4)|IdoA{2S}(a1-3)GalNS(b1-4)
HS2ST1-mediated sulfation reaction rule
...IdoA(a1-4)GlcN{,3}<,6>S(a1-4)|...GlcA(a1-4)GlcN{,3}<,6>S(a1-4)
HS3ST1 sulfation reaction rule
...IdoA<2S>(a1-4)GlcN{,3}<,6>S(a1-4)
generic heparan sulfate GlcN sulfation reaction rule
...IdoA<2S>(a1-4)GlcN{,3}<,6>S(a1-4)|...GlcA<2S>(a1-4)GlcN{,3}<,6>S(a1-4)
HS3ST5 sulfation reaction rule
...IdoA<2S>(a1-4)GlcN<,3>{,6}S(a1-4)|...GlcA<2S>(a1-4)GlcN<,3>{,6}S(a1-4)
HS6ST sulfation reaction rule
...IdoA<2S>(a1-4)GlcN,3{!,6}S(a1-4)|...GlcA<2S>(b1-4)GlcN,3{!,6}S(a1-4)
SULF1 and SULF2 desulfation reaction rule
{Neu5Ac(a2-3)}Gal(b1-3)<[...]>GalNAc(a1-?)Ser/Thr
ST3GAL1-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-3)}Gal(b1-3)GalNAc(a1-?)Ser/Thr|{Neu5Ac(a2-3)}Gal(b1-3)GalNAc(b1-?)...Glc(b1-?)Cer
ST3GAL2-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-3)}Gal(b1-4)GlcNAc(b1-?)|{Neu5Ac(a2-3)}Gal(b1-3)GlcNAc(b1-?)|{Neu5Ac(a2-3)}Gal(b1-3)GalNAc(b1-?)
ST3GAL3-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-3)}Gal(b1-?)GlcNAc(b1-?)
ST3GAL4-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-3)}Gal(b1-?)Cer|{Neu5Ac(a2-3)}Gal(b1-4)Glc(b1-?)Cer
ST3GAL5-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-3)}Gal(b1-4)GlcNAc(b1-?)
ST3GAL6-mediated n-acetylneuraminic acid transferase activity reaction rule
{Glc1P<->Glc6P}
PGM2-mediated mutase activity reaction rule
{Neu5Ac(a2-6)}Gal(b1-4)GlcNAc(b1-?)
ST6GAL1-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-6)}GalNAc(b1-4)GlcNAc(b1-?)|{Neu5Ac(a2-6)}Gal(b1-4)GlcNAc(b1-?)
ST6GAL2-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-6)}GalNAc(a1-?)Ser/Thr|Gal(b1-3){[Neu5Ac(a2-6)]}GalNAc(a1-?)Ser/Thr|Neu5Ac(a2-3)Gal(b1-3){[Neu5Ac(a2-6)]}GalNAc(a1-?)Ser/Thr
ST6GALNAC1/2-mediated n-acetylneuraminic acid transferase activity reaction rule
Gal(b1-3){[Neu5Ac(a2-6)]}GalNAc(b1-?)
ST6GALNAC3/4-mediated n-acetylneuraminic acid transferase activity reaction rule
Neu5Ac(a2-3)Gal(b1-3){[Neu5Ac(a2-6)]}GalNAc(b1-?)…Cer
ST6GALNAC5/6-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-8)}Neu5Ac(a2-3)Gal(b1-?)Glc(b1-?)Cer|{Neu5Ac(a2-8)}Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-?)Glc(b1-?)Cer|{Neu5Ac(a2-8)}Neu5Ac(a2-3)Gal(b1-?)...Glc(b1-?)Cer
ST8SIA1-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-8)}Neu5Ac(a2-?)
ST8SIA2/3/4-mediated n-acetylneuraminic acid transferase activity reaction rule
{GlcNAc1P<->GlcNAc6P}
PMG3-mediated mutase activity reaction rule
{Neu5Ac(a2-8)}Neu5Ac(a2-8)Neu5Ac(a2-3)Gal(b1-?)Glc(b1-?)Cer|{Neu5Ac(a2-8)}Neu5Ac(a2-3)Gal(b1-?)...Glc(b1-?)Cer
ST8SIA5-mediated n-acetylneuraminic acid transferase activity reaction rule
{Neu5Ac(a2-8)}Neu5Ac(a2-?)...Ser/Thr
ST8SIA6-mediated n-acetylneuraminic acid transferase activity onto o-linked glycans reaction rule
{GlcA(b1-3)}Gal(b1-4)GlcNAc(b1-?)
B3GAT1/2-mediated glucuronyltransferase activity reaction rule
{Gal(b1-3)}GlcNAc(b1-?)
B3GALT1/2-mediated β1-3 galactosyltransferase activity on terminal n-acetylglucosamine reaction rule
{Gal(b1-3)}GalNAc(b1-4)...Glc(b1-?)Cer|[anchored-protein][6EtNP]Man(a1-2)Man(a1-2)Man(a1-6)[2EtNP][{Gal(b1-3)}GalNAc(b1-4)]Man(a1-4)GlcN(a1-6)(ancyl)PI
B3GALT4-mediated galactosyltransferase activity reaction rule
{Gal(b1-3)}GlcNAc(b1-3)...Glc(b1-?)Cer|{Gal(b1-3)}GalNAc(b1-3)Gal(a1-4)...Glc(b1-?)Cer|{Gal(b1-3)}GlcNAc(b1-3)[GalNAc(b1-6)]GalNAc(a1-1)Ser/Thr|GalNAc(b1-6)[{Gal(b1-3)}GlcNAc(b1-3)]GalNAc(a1-1)Ser/Thr
B3GALT5-mediated galactosyltransferase activity reaction rule
{Fruc6P->GlcN6P}
GFPT1/2 aminotransferase activity reaction rule
{Gal(a1-4)}Gal(b1-4)Glc(b1-?)|{Gal(a1-4)}Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-?)
A4GALT-mediated galactosyltransferase activity reaction rule
{Gal(b1-4)}GlcNAc(b1-?)|{Gal(b1-4)}Glc(b1-?)
B4GALT1-mediated galactosyltransferase activity reaction rule
{Gal(b1-4)}GlcNAc(b1-?)
β1-4 galactosyltransferase activity reaction rule
{Gal(b1-4)}Glc(b1-?)Cer
B4GALT6-mediated galactosyltransferase activity reaction rule
{Gal(b1-3)}GalNAc(a1-?)Ser/Thr
C1GALT1-mediated n-acetylgalactosamine transferase activity reaction rule
{Gal(b1-?)}Cer
UGT8-mediated galactosyltransferase activity reaction rule
Gal{6S}(b1-4)GlcNAc(b1-3)Gal(b1-4)|...Gal{6S}(b1-4)GlcNAc6S(b1-3)|Neu5Ac(a2-3)Gal{6S}(b1-4)GlcNAc6S(b1-?)|Neu5Ac(a2-3)Gal{6S}(b1-4)GlcNAc(b1-?)
CHST1-mediated sulfation activity reaction rule
GlcNAc{6S}(b1-6)[Gal(b1-3)]GalNAc|GlcNAc{6S}(b1-3)Gal(b1-4)GlcNAc|GlcNAc{6S}(b1-2)Man|GlcNAc{6S}(b1-6)Man
CHST2-mediated sulfation reaction rule
GlcNAc{6S}(b1-6)[Gal(b1-3)]GalNAc|GlcNAc{6S}(b1-3)Gal(b1-4)GlcNAc|GlcNAc{6S}(b1-6)Man
CHST5/6-mediated sulfation reaction rule
Gal{3S}(b1-?)Cer|Gal{3S}(b1-4)Glc(b1-?)Cer
GAL3ST1-mediated galactose sulfation activity reaction rule
Gal{3S}<6S>(b1-4)<[Fuc(a1-3)]>GlcNAc(b1-?)|Gal{3S}(b1-3)<[Fuc(a1-4)]>GlcNAc(b1-?)
GAL3ST2-mediated sulfation activity reaction rule
Gal{3S}<6S>(b1-4)<[Fuc(a1-3)]>GlcNAc(b1-?)
GAL3ST3-mediated sulfation activity reaction rule
Gal{3S}(b1-3)<GlcNAc(b1-6)>GalNAc(b1-?)
GAL3ST4-mediated sulfation activity reaction rule
GlcA{3S}(b1-3)Gal(b1-4)GlcNAc(b1-?)
CHST10-mediated sulfation reaction rule
Gal(b1-3)[GlcNAc{6S}(b1-6)]GalNAc|Gal(b1-3)[Gal(b1-4)GlcNAc{6S}(b1-6)]GalNAc
CHST4-mediated sulfation reaction rule
GalNAc{4S}(b1-4)GlcNAc(b1-?)
CHST8/9-mediated sulfation activity reaction rule
GlcNAc{6P}
NAGK hexokinase activity on n-acetylglucosamine reaction rule
{ATP->PAPS}
PAPSS sulfotransferase activty reaction rule
{GlcA(??-?)}R
xenobiotic glucuronidation reaction rule
Glc{6P}|Fruc{6P}|Man{6P}
Hexokinase activity on glucose, fructose, or mannose reaction rule
{UDP-Gal<->UDP-Glc}|{UDP-GalNAc<->UDP-GlcNAc}
GALE-mediated UPD-galactose to UDP-n-acetylgalactosamine or UDP-glucose to UDP-n-acetylglucosamine conversion reaction rule
Glc{6P}|Fruc{6P}|GlcN{6P}|Man{6P}
HK1-mediated kinase activity on glucose, fructose, glucosamine, or mannose reaction rule
Glc{[Extracellular]->[Cyto]}
SLC2A-mediated glucose transport from the extracellular space to the cytosol reaction rule
...{![Fuc(a1-6)]}GlcNAc(b1-?)Asn
removal of core fucose by fucosidase reaction rule
...<[...]>GlcNAc(b1-?){!Asn}
AGA removal of N-linked glycan from protein reaction rule
...<[...]>GlcNAc(b1-4){!GlcNAc(b1-?)}
CTBS-mediated lysosomal N-linked glycan degradation reaction rule
{!Gal(b1-?)}
GLB1-mediated degalactosylation of N-linked glycans reaction rule
{!GalNAc(b1-?)}
HEXA/B-mediated de-nacetylgalactosaminylation reaction rule
{!Man(a1-?)}
MAN2B1/2 and MAN2C1-mediated mannosidic activity reaction rule
{!Man(b1-?)}GlcNAc(b1-?)
MANBA beta-mannosidic activity reaction rule
{!Neu5Ac(a2-3)}Gal(b1-?)|{!Neu5Ac(a2-6)}Gal(b1-?)
NEU1 neuraminidic activity reaction rule
{!Neu5Ac(a2-3)}Gal(b1-?)
NEU2 neuraminidic activity reaction rule
{!Neu5Ac(a2-?)}Gal(b1-?)|{!Neu5Ac(a2-?)}Neu5Ac(a2-?)
NEU3/4 neuraminidic activity reaction rule
...<[...]>GlcNAc(b1-4){!GlcNAc(b1-?)Asn}
ENGASE-mediated endoglycosidase activity for N-linked glycan lysosomal degradation reaction rule
{!Gal(a1-?)}Gal
GLA-mediated degalactosylation reaction rule
{!Glc(b1-?)}Cer
GBA glucosylceramide glucosidic activity reaction rule
{GDP-Man->GDP-4-6-dehydro-6-deoxy-D-Mannose}
GMDS-mediated conversion of GDP-mannose into GDP-4-6-dehydro-6-deoxy-D-Mannose reaction rule
{!Gal(b1-?)}Cer
GALC-mediated galactosylceramide breakdown reaction rule
IdoA{!2S}(a1-?)
IDS-mediated desulfation of iduronic acid reaction rule
{!IdoA(a1-?)}
IDUA-mediated iduronididic activity reaction rule
GlcN{!S}
SGSH-mediated glucosamine desulfation reaction rule
GlcN{Ac}(a1-4)
HGSNAT-mediate deacetylation reaction rule
{!GlcNAc(a1-4)}
NAGLU-mediated n-acetylglucosaminidic activity reaction rule
GlcA{!2S}(b1-4)
ARSK-mediated desulfation reaction rule
{!GlcA(b1-3)}
GUSB-mediated glucuronididic activity reaction rule
GlcNAc{!6S}(a1-4)
GNS-mediated desulfation reaction rule
GalNAc{!4S}(b1-4)
ARSB-mediated desulfation activity reaction rule
{ManNAc6P->Neu5Ac}|{Man6P->Kdn}
NANS-mediated n-acetylneuraminic acid or kdn synthesis reaction rule
...GalNAc{!6S}(b1-4)|...Gal{!6S}(b1-4)
GALNS sulfatase activity reaction rule
Neu5{,9}Ac(a2-?)
CASD-mediated n-acetylneuraminic acid acetyltransferase activity reaction rule
Neu5{!,9}Ac(a2-?)
SIAE-mediated n-acetylneuraminic acid deacetylation activity reaction rule
Glc{1P<->6P}
PGM1-mediated mutase activity reaction rule
Man{1P<->6P}
PMM1/2-mediated mutase activity reaction rule
{Man(a1-?)}Dol-P
DPM1-mediated dolichol-mannose synthesis reaction rule
{Glc(a1-?)}Dol-P
ALG5-mediated dolichol-glucose synthesis reaction rule
{GDP-4-keto-6-deoxy-D-mannose->GDP-Fuc}
GFUS-mediated synthesis of GDP-fucose reaction rule
GDP-Fuc{[Cytoplasm]->[Golgi]}
SLC35C1-mediated fucose transfer from the cytoplasm to the Golgi reaction rule
UDP-Gal{[Cyto]->[Golgi]}
SLC35A2-mediated UDP-galactose transport from the cytoplasm to the Golgi reaction rule
UDP-GlcA{[Cyto]->[ER]}|UDP-GlcA{[Cyto]->[Golgi]}|UDP-GalNAc{[Cyto]->[ER]}|UDP-GalNAc{[Cyto]->[Golgi]}
SLC35D1-mediated UDP-glucuronic acid and UDP-n-acetylgalactosamine transport from the cytoplasm to the ER or Golgi reaction rule
UDP-GlcNAc{[Cyto]->[Golgi]}
SLC35A3-mediated UDP-GlcNAc transport from the cytoplasm to the Golgi reaction rule
UDP-GlcNAc{[Cyto]->[Golgi]}|UDP-Glc{[Cyto]->[Golgi]}|GDP-Man{[Cyto]->[Golgi]}
SLC35D2-mediated UDP-nacetylglucosamine, UDP-glucose, or UDP-mannose transport from the cytoplasm to the Golgi reaction rule
PAPS{[Cyto]->[Golgi]}
SLC35B-mediated PAPS transport from the cytosol to the Golgi reaction rule
CMP-Neu5Ac{[Cyto]->[Golgi]}
SLC35A1-mediated transfer of n-acetylneuraminic acid from the cytosol to the Golgi reaction rule
UDP-Xyl{[Cyto]->[Golgi]}|UDP-GlcNAc{[Cyto]->[Golgi]}
SLC35B4-mediated xylose transport from the cytoplasm to the Golgi reaction rule
Glc(a1-2)Glc(a1-3)Man(a1-2)Man(a1-2)Man(a1-3)[Man(a1-2)Man(a1-6)[Man(a1-2)Man(a1-3)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4){GlcNAc(a1-?)Dol-P-P->GlcNAc(b1-?)Asn}
STT3A/B-medaited oligosaccharyltransferase activity reaction rule
{Man1P->GDP-Man}
GMPPA/B-mediated GDP-mannose synthesis reaction rule
{Man(a1-3)}Man(a1-6)[Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG2-mediated mannosyltransferase activity reaction rule
{Man(a1-2)}Man(a1-3)Man(a1-6)[Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P|Man(a1-2)Man(a1-3)[{Man(1-3)}Man(1-6)]Man(a1-6)[Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG9-mediated mannosyltransferase activity reaction rule
Man(a1-2)Man(a1-3){[Man(a1-6)]}Man(a1-6)[Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG12-mediated mannosyltransferase activity reaction rule
Man(a1-2)Man(a1-6)[Man(a1-2)Man(a1-3)]Man(a1-6)[{Glc(a1-3)}Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG6-mediated glucosyltransferase reaction rule
Man(a1-2)Man(a1-6)[Man(a1-2)Man(a1-3)]Man(a1-6)[{Glc(a1-2)}Glc(a1-3)Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG8-mediated glucosyltransferase activity reaction rule
Man(a1-2)Man(a1-6)[Man(a1-2)Man(a1-3)]Man(a1-6)[{Glc(a1-2)}Glc(a1-3)Glc(a1-3)Man(a1-2)Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG10-mediated glucosyltransferase activity reaction rule
{Dol-P->GlcNAc(a1-?)Dol-P-P}
DPAGT1 n-acetylglucosaminyltranser activity reaction rule
{GlcNAc(b1-4)}GlcNAc(a1-?)Dol-P-P
ALG13/14-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc1P->UDP-GlcNAc}|{GalNAc1P->UDP-GalNAc}
UAP1-mediated UPD-GlcNAc or UDP-GalNAc synthesis reaction rule
{Man(b1-4)}GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG1-mediated mannosyltransferase activity reaction rule
{Man(a1-3)}Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)|{Man(a1-6)}[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG2-mediated mannosyltransferase activity reaction rule
Man(a1-6)[{Man(a1-2)}Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P|Man(a1-6)[{Man(a1-2)}Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc(a1-?)Dol-P-P
ALG11-mediated mannosyltransferase reaction rule
{GlcNAc(a1-?)-P-}Man(a1-2)Man(a1-3)|Man(a1-2){GlcNAc(a1-?)-P-}Man(a1-2)Man(a1-6)
GNPTAB-mediated n-acetylglucosaminyltransferase activity reaction rule
{!GlcNAc(a1-?)-P-}Man(a1-2)Man(a1-3)|Man(a1-2){!GlcNAc(a1-?)-P-}Man(a1-2)Man(a1-6)
NAGPA-mediated n-acetylglucosaminidic activity reaction rule
{!Man(a1-2)}Man(a1-?)
α1-2 mannosidic activity reaction rule
{!Man(a1-2)}Man(a1-3)Man(a1-6)
MAN1B1-specific α1-2 mannosidic activity reaction rule
Fuc{1P}
FCSK-mediated fucose phosphorylation reaction rule
{!Man(a1-6)}...Man(a1-6)Man(b1-4)|{!Man(a1-6)}Man(a1-6)Man(b1-4)|{!Man(a1-3)}...Man(a1-6)Man(b1-4)|{!Man(a1-3)}Man(a1-6)Man(b1-4)
MAN2A1/MAN2A2 mannosidic activity reaction rule
{!Glc(a1-2)}Glc(a1-3)Glc(a1-3)Man(a1-2)
MOGS-mediated deglucosylation reaction rule
{!Glc(a1-3)}Man(a1-2)|{!Glc(a1-3)}Glc(a1-3)Man(a1-2)
GANAB glucosidic activity reaction rule
{Glc(a1-3)}Man(a1-2)Man(a1-2)Man(a1-3)
UGGT1/2-mediated glucosyltransferase activity reaction rule
{!Glc(a1-2)Glc(a1-3)Glc(a1-3)Man(a1-2)}Man(a1-2)|{!Glc(a1-3)Glc(a1-3)Man(a1-2)}Man(a1-2)|{!Glc(a1-3)Man(a1-2)}Man(a1-2)
MANEA endoglycosidic activity reaction rule
...GlcNAc(b1-4){[Fuc(a1-6)]}GlcNAc(b1-?)
FUT8-mediated core N-linked glycan fucosylation reaction rule
{GlcNAc(b1-2)}Man(a1-3)...Man(b1-4)GlcNAc(b1-4)GlcNAc(b1-?)
MGAT1-mediated n-acetylglucosaminyltransferase activity reaction rule
{GlcNAc(b1-2)}Man(a1-6)Man(b1-4)
MGAT2-mediated n-acetylglucosaminyltransferase activity reaction rule
{Neu5Ac->CMP-Neu5Ac}
CMAS-mediated CMP-n-acetylneuraminic acid synthesis reaction rule
{GlcNAc(b1-4)}[...]Man(b1-4)
MGAT3-mediated bisecting n-acetylglucosaminyltransferase activity reaction rule
GlcNAc(b1-2){[GlcNAc(b1-4)]}Man(a1-3)
MGAT4-mediated N-linked glycan branching reaction rule
{GalNAc(a1-?)}Ser/Thr
polypeptide n-acetylgalactosaminyltransferase activity reaction rule
{Fuc1P->GDP-Fuc}
FPGT-medaited GDP-fucose transfer reaction rule
GlcA<NS,>{!3S}<,6S>(b1-4)
ARSG-mediated desulfation reaction rule
{!Glc(a1-2)}Gal(b1-?)5-hydroxy-L-lysyl[COL]
Glucosidase activity by PGGHG in collagen degradation reaction rule
...Gal(b1-4)Xyl{!2P}(b1-?)Ser
PXYLP1-mediated phosphatase activity reaction rule
{!...GlcA(b1-4)}GlcN<,3><,6>S(a1-?)&...GlcA(b1-4){!GlcN<,3><,6>S(a1-?))
HPSE glucuronidase removal reaction rule
{!...GlcNAc(b1-4)}GlcA(a1-3)&...GlcNAc(b1-4){!GlcA(a1-3)}
Hyaluronidase heparan sulfate breakdown reaction rule
NAGA-mediated de-nacetylgalactosaminylation reaction rule
GlcNAc(b1-2){[GlcNAc(b1-6)]}Man(a1-6)
MGAT5-mediated β1-6-nacetylglucosaminyltransferase activity reaction rule
!Gal(b1-?)&GlcNAc(b1-2)
MAN2A1/2 substrate restrictions and requirements constraint
!@GlcNAc(b1-4)...Man(b1-4)
B3GALNT2 restriction of galactosyltransferase activity constraint
!GlcNAc(b1-6)[GlcNAc(b1-3)]Gal(b1-4)@GlcNAc(b1-?)
terminal fucosyltransferase substrate restrictions constraint
nNeuAc(a2-?)<=3
B4GALNT1 n-acetylneuraminic acid cardinality constraint
Xyl&!IdoA(a1-3)
presence of xylose and lack of iduronic acid substrate constraint
Xyl
presence of xylose constraint
GlcNAc(b1-6)GalNAc(a1-?)
A4GNT substrate restriction constraint
!NeuAc(a2-3)Gal(b1-3)GalNAc(a1-?)&!Gal(b1-3 3S])GalNAc(a1-?)
GCNT substrate restrictions constraint
!GlcN6OS(a1-4)
EXT substrate restriction constraint
GlcNAc(b1-2)&!GlcNAc(b1-4)[...]Man(b1-4)&!Fuc(a1-?)
FUT8 substrate restrictions constraint
!Gal(b1-4)GlcNAc(b1-?)
ST3GAL1 substrate restriction constraint
nNeu5Ac(a2-3)=1
ST6GALNAC3/4/5 n-acetylneuraminic acid cardinality constraint
nNeu5Ac(a2-?)<4
ST6GALNAC6 n-acetylneuraminic acid cardinality constraint
nNeu5Ac<5
ST8SIA1 n-acetylneuraminic acid cardinality constraint
!Cer
glycosphingolipid activity prohibited constraint
GlcNAc(b1-2)
MGAT2 terminal β1-2 n-acetylglucosamine substrate requirement constraint
nNeu5Ac<4
ST8SIA5 n-acetylneuraminic acid cardinality constraint
!GlcA(b1-3)Gal(b1-4)GlcNAc(b1-?)
B3GAT substrate restriction constraint
!Gal(b1-4)GlcNAc(b1-?)&!@GlcNAc(b1-4)[...]Man(b1-4)
B3GALT substrate restrictions constraint
nNeu5Ac(a2-?)<4&GalNAc(b1-4)<3
B3GALT4 n-acetylneuraminic acid and n-acetylgalactosamine cardinalities constraint
!Asn
prohibited activity on N-linked glycans constraint
!Gal(b1-3)GlcNAc(b1-?)&!@GlcNAc(b1-4)[...]Man(b1-4)
B4GALT substrate restrictions constraint
nGlcNAc(b1-2)=2
MGAT3 n-acetylglucosamine cardinality constraint
GalNAc(a1-?)|GlcNAc(b1-4)GlcNAc
CHST8/9 substrate restrictions constraint
!Gal(b1-?)&!GlcNAc(b1-4)[...]Man(b1-4)
MGAT4A substrate restrictions constraint
!GlcNAc(b1-4)[…]Man(b1-4)&!Gal(b1-?)
MGAT4B/C and MGAT5/5B substrate restrictions constraint
DPAGT1-mediated transfer of GlcNAc from UDP-GlcNAc onto dolichol diphosphate which initiates N-linked glycan biosynthesis
ALG13 and ALG14-mediated transfer of GlcNAc from UDP-GlcNAc onto GlcNAc(α1-P-P-Dolichol) that forms GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG1-mediated transfer of mannose onto the GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that creates Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG2-mediated transfer of mannose from UDP-mannose onto Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-3)Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG2-mediated transfer of mannose from UDP-mannose onto Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-6)Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG2-mediated transfer of mannose from UDP-mannose onto Man(α1-3)Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG2-mediated transfer of mannose from UDP-mannose onto Man(α1-6)Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG11-mediated transfer of mannose from UDP-mannose onto Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG11-mediated transfer of an additional mannose from UDP-mannose onto Man(α1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms form Man(α1-2)Man(α1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG3-mediated transfer of mannose from UDP-mannose onto Man(α1-2)Man(α1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-2)Man(α1-3)[Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG9-mediated transfer of mannose from UDP-mannose onto Man(α1-2)Man(α1-3)[Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG9-mediated transfer of mannose from UDP-mannose onto Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG9-mediated transfer of mannose from UDP-mannose onto Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG6-mediated transfer of glucose from UDP-glucose onto Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG8-mediated transfer of glucose from UDP-glucose onto Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) that forms Glc(α1-3)Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
ALG10-mediated transfer of glucose from UDP-glucose onto Glc(α1-3)Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) which forms Glc(α1-2)Glc(α1-3)Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol)
MOGS trims terminal Glc(α1-2) from the dolichol precursor to form Glc(α1-3)Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
GANAB-facilitated trimming of glucose from Glc(α1-3)Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) which forms Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
GANAB-facilitated trimming of glucose from Glc(α1-3)Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(α1-P-P-Dolichol) which forms Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN1B1-facilitated trimming of terminal mannose from Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms Man(α1-2)Man(α1-3)[Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN1A1,MAN1A2, or MAN1C1-facilitated cleavage of Man(α1-2) linkage from Man(α1-2)Man(α1-3)[Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms Man(α1-2)Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN1A1,MAN1A2, or MAN1C1-facilitated cleavage of Man(α1-2) linkage from Man(α1-2)Man(α1-3)[Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms Man(α1-3)[Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN1A1,MAN1A2, or MAN1C1-facilitated cleavage of Man(α1-2) linkage from Man(α1-2)Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN1A1,MAN1A2, or MAN1C1-facilitated cleavage of Man(α1-2) linkage from Man(α1-3)[Man(α1-3)[Man(α1-2)Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT1-mediated transfer of GlcNAc from UDP-GlcNAc onto Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN2A1 or MAN2A2-facilitated cleavage of Man(α1-3) linkage from GlcNAc(β1-2)Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[Man(α1-6)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN2A1 or MAN2A2-facilitated cleavage of Man(α1-3) linkage from GlcNAc(β1-2)Man(α1-3)[Man(α1-6)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN2A1 or MAN2A2-mediated cleavage of Man(α1-6) linkage from GlcNAc(β1-2)Man(α1-3)[Man(α1-3)[Man(α1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MAN2A1 or MAN2A2-facilitated cleavage of Man(α1-3) linkage from GlcNAc(β1-2)Man(α1-3)[Man(α1-3)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT2-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT5-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) to form GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT4A, MGAT4B, or MGAT4C-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) to form GlcNAc(β1-2)[GlcNAc(β1-4)]Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT3-mediated transfer of a bisecting GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT4A, MGAT4B, or MGAT4C-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) to form GlcNAc(β1-2)[GlcNAc(β1-4)]Man(α1-3)[GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT5-mediated transfer of GlcNAc onto GlcNAc(β1-2)[GlcNAc(β1-4)]Man(α1-3)[GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)[GlcNAc(β1-4)]Man(α1-3)[GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT5-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT4A, MGAT4B, or MGAT4C-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)[GlcNAc(β1-2)]Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
MGAT4A, MGAT4B, or MGAT4C-mediated transfer of GlcNAc onto GlcNAc(β1-2)Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn) which forms GlcNAc(β1-2)[GlcNAc(β1-4)]Man(α1-3)[GlcNAc(β1-4)][GlcNAc(β1-4)[GlcNAc(β1-6)]Man(α1-6)]Man(β1-4)GlcNAc(β1-4)GlcNAc(β1-Asn)
polypeptide GalNAc-meidated transfer of GalNAc onto serine or threonine residues to form GalNAc(α1-Ser/Thr).
C1GALT1 and C1GALT1C1-mediated transfer of galactose onto GalNAc(α1-Ser/Thr) which forms Gal(β1-3)GalNAc(α1-Ser/Thr)
B3GNT6-mediated transfer of GlcNAc onto GalNAc(α1-Ser/Thr) that forms the core 3 O-GalNAc structure GlcNAc(β1-3)GalNAc(α1-Ser/Thr)
GCNT1 or GCNT4-mediated transfer of GlcNAc onto Core 1 Gal(β1-3)GalNAc(α1-Ser/Thr) that forms the core 2 structure Gal(β1-3)[GlcNAc(β1-6)]GalNAc(α1-Ser/Thr)
GCNT3-mediated transfer of GlcNAc onto core 3 GlcNAc(β1-3)GalNAc(α1-Ser/Thr) that forms the core 4 structure GlcNAc(β1-3)[GlcNAc(β1-6)]GalNAc(α1-Ser/Thr)
POFUT1 or POFUT2-mediated transfer of fucose onto serine or threonine residues on EGF-like repeats which forms Fuc(α1-Ser/Thr)
Lunatic, Maniac, or Radical fringe-mediated transfer of GlcNAc onto O-linked fucose that forms GlcNAc(β1-3)Fuc(α1-Ser/Thr)
COLGALT1 or COLGALT2-mediated galactose transfer onto collagen residues
POMT1 or POMT2-mediated transfer of mannose to serine or threonine residues on proteins
POMGNT1-mediated transfer of GlcNAc onto O-linked mannose which forms GlcNAc(β1-2)Man(α1-Ser/Thr)
POMGNT2-mediated transfer of GlcNAc onto O-linked mannose which forms GlcNAc(β1-4)Man(α1-Ser/Thr)
MGAT5B -mediated transfer of GlcNAc onto POMGNT1-type O-mannose glycan which forms GlcNAc(β1-2)[GlcNAc(β1-6)]Man(α1-Ser/Thr)
B3GALNT2-mediated transfer of GalNAc onto POMGNT2-type O-mannose structure which initiates α-Dystroglycan synthesis
FKTN-mediated transfer of ribitol in a phosphate linkage to form Ribo(5-P-3)GalNAc(β1-3)GlcNAc(β1-4)Man(α1-Ser/Thr)
FKRP-mediated transfer of an additional ribitol in a phosphate linkage which forms Ribo(5-P-1)Ribo(5-P-3)GalNAc(β1-3)GlcNAc(β1-4)Man(α1-Ser/Thr)
RXYLT1-mediated transfer of the first xylose onto ribitol which forms Xyl(β1-4)Ribo(5-P-1)Ribo(5-P-3)GalNAc(β1-3)GlcNAc(β1-4)Man(α1-Ser/Thr)
B4GAT1-mediated transfer of first glucuronic acid onto xylose to form GlcA(β1-4)Xyl(β1-4)Ribo(5-P-1)Ribo(5-P-3)GalNAc(β1-3)GlcNAc(β1-4)Man(α1-Ser/Thr)
LARGE1 or LARGE2-mediated transfer of xylose in a β1-3 linkage to glucuronic acid on α-dystroglycan
LARGE1 or LARGE2-mediated transfer of glucuronic acid in a β1-3 linkage to xylose on α-dystroglycan
XYLT1 or XYLT2-mediated transfer of xylose onto serine or threonine to initate GAG synthesis
FAM20B phosphorylation of o-linked xylose on the 2 carbon which forms Gal(β1-4)Xyl2P(α1-)
B3GALT6-mediated transfer of galactose on core GAG structure that forms Gal(β1-3)Gal(β1-4)Xyl2P(α1-)
B3GAT3-mediated transfer of glucuronic acid on core GAG structure that forms GlcA(β1-3)Gal(β1-3)Gal(β1-4)Xyl2P(α1-)
CSGALNACT1 and CSGALNACT2-mediated transfer of GalNAc onto core O-xylsoe GAGs to form chondroitin and dermatan sulfate core structures GalNAc(β1-4)GlcA(β1-3)Gal(β1-3)Gal(β1-4)Xyl2P(α1-)
EXTL3-mediated transfer of GlcNAc onto O-xylose GAGs which forms the heparan sulfate core structure GlcNAc(α1-4)GlcA(β1-3)Gal(β1-3)Gal(β1-4)Xyl2P(α1-)
CHSY1,CHSY3,CHPF, and CHPF2-mediated addition of glucuronic acid onto chondroitin and dermatan sulfate chains
EXT1 and EXT2-mediated addition of glucuronic acid onto heparan sulfate chains
CHSY1, CHSY3, and CHPF-mediated transfer of GalNAc onto chondroitin and dermatan sulfate chains
EXT1, EXT2, and EXTL1-mediated transfer of GlcNAc onto heparan sulfate chains
CHST3 and CHST7-mediated sulfation of GalNAc6C preseent in chondroitin sulfates
CHST11-13-mediated sulfation of GalNAc4C present on chondroitin sulfates
CHST14-mediated sulfation of GalNAc4C present on dermatan sulfates
NDST1-4-mediated sulfation of amine groups of glucosamine present in heparan sulfates
HS2ST1-mediated sulfation of iduronic acids on the 2 carbon of heparan sulfates
HS3ST1,2,4,5,6, HS3ST3A1, and HS3ST3B1-mediated sulfation of sulfate GlcNAc3C present on heparan sulfates
HS6ST1-3-mediated sulfation of GlcN residues on the 6 carbon of heparan sulfates
DSE and DSEL-mediated epimerization of glucuronic acids into iduronic acids on chonroitin sulfates to form dermatan sulfates
GLCE epimerization of glucuronic acid into iduronic acid on heparan sulfate
UGCG-mediated transfer of glucose onto ceramide to initiate glucosylceramide synthesis
B4GALT6-mediated transfer of galactose onto glucosylceramide
B4GALNT1-mediated transfer of GalNAc onto Gal(β1-4)Glc(β1-Cer) which initiating ganglioside synthesis
B3GNT5-mediated transfer of GlcNAc onto Gal(β1-4)Glc(β1-Cer) that initiates the lacto and neolacto-series
A4GALT-mediated transfer of galactose onto Gal(β1-4)Glc(β1-Cer) initiating globo-series
B3GALT4-mediated transfer of galactose onto GalNAc(β1-4)Gal(β1-4)Glc(β1-Cer) that completes the ganglioside core structures
B3GALT5-mediated transfer of galactose onto GlcNAc(β1-4)Gal(β1-4)Glc(β1-Cer) that completes lacto series core structures
B3GALNT1-mediated transfer of GalNac onto Gal(α1-3)Gal(β1-3)Gal(β1-4)Glc(β1-Cer) that that completes globo series glycolipid synthesis
B4GALT-mediated transfer of galactose onto GlcNAc(β1-3)Gal(β1-4)Glc(β1-Cer), completing the neolacto series core structure
B3GALNT1,2-mediated transfer of galactose onto terminal GlcNAc that forms Gal(β1-3)GlcNAc(β1-?) structures
B4GALT-mediated transfer of transfer galactose onto terminal GlcNAc residues which forms Gal(β1-4)GlcNAc(β1-?) structures
B3GNT-mediated transfer of GlcNAc onto terminal galactose residues that forms GlcNAc(β1-4)Gal(β1-3)GlcNAc(β1-4)
FUT1,2-mediated fucose addition onto terminal galactose residues forming Fuc(α1-2)Gal(β1-3) structures
FUT3-7,9-mediated transfer of fucose onto GlcNAc residues of lactosamine that form Gal(β1-3/4)[Fuc(α1-3)]GlcNAc(β1-?)
FUT3,5-mediated transfer of fucose onto lactosamine residues that forms Gal(β1-3/4)[Fuc(α1-3)]GlcNAc(β1-?) structures
ST6GAL1,2-mediated sialylation of terminal galactose residues which form Neu5Ac(α1-6)Gal(β1-?)
ST3GAL1,3,4 and 6-mediated sialylation of terminal galactose in O-linked glycan contexts
ST3GAL3 and 4-mediated sialylation of terminal galactose in N-linked glycan contexts
ST3GAL2 and 5-mediated sialylation of terminal galactose in glycolipid contexts
ST6GALNAC3-6-mediated sialylation of terminal GalNAc residues in glycolipid glycan contexts
ST8SIA2,4 and 6-mediated polysialylation in O-GalNAc glycan contexts
ST8SIA2-4 and 6-meidated polysialylation in N-glycan contexts
ST8SIA1,3, and 5-mediated polysialylation in glycolipid contexts
chondroitin and dermatan sulfate core structure biosynthetic pathway event
chondroitin and dermatan sulfate polymerization pathway event
chondroitin and dermatan sulfate sulfation pathway
collagen glycosylation pathway event
core 1 type o-N-acetylgalactosamine type glycan biosynthetic pathway event
core 2 type o-N-acetylgalactosamine type glycan biosynthetic pathway event
core 3 type o-N-acetylgalactosamine type glycan biosynthetic pathway event
core 4 type o-N-acetylgalactosamine type glycan biosynthetic pathway event
dolichol precursor biosynthetic pathway event
dolichol precursor post-processing pathway event
ganglioside core structure biosynthetic pathway event
globo-series core structure biosynthetic pathway event
glucosylceramide biosynthetic pathway event
heparan sulfate core structure biosynthetic pathway event
heparan sulfate polymerization pathway event
heparan sulfate sulfation pathway
lacto-series core structure biosynthetic pathway event
n-linked glycan branching biosynthetic pathway event
neolacto-series core structure biosynthetic process
o-fucosylation type glycan biosynthetic pathway event
o-linked xylose glycosaminoglycan core structure biosynthetic pathway event
POMGNT1-type o-mannose glycan biosynthetic pathway event
POMGNT2-type o-mannose glycan biosynthetic pathway event
terminal fucosylation biosynthetic pathway event
terminal sialylation biosynthetic pathway event
TMTC-type o-mannosylation event
type i lactosamine biosynthetic pathway event
type ii lactosamine biosynthetic pathway event
α-Dystroglycan biosynthetic pathway event
ST6GALNAC1-4 sialylate terminal GalNAc residues in O-GalNAc glycan contexts