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"data_provenance": [ { "name": "genbank" } ], "description": "This phylogeny shows evolutionary relationships of SARS-CoV-2 viruses from the ongoing novel coronavirus COVID-19 pandemic.\n\nAll data we use were deposited in GISAID by scientists around the world.\nWe gratefully acknowledge the authors, originating and submitting laboratories of the genetic sequence and metadata made available through [GISAID](https://gisaid.org) on which this research is based. A full listing of all originating and submitting laboratories is available below. An attribution table is available by clicking on \"Download Data\" at the bottom of the page and then clicking on \"Strain Metadata\" in the resulting dialog box.\n", "display_defaults": { "branch_label": "clade", "color_by": "clade_membership", "distance_measure": "div", "geo_resolution": "region", "map_triplicate": true, "transmission_lines": false }, "filters": [ "region", "country", "division", "new_node", "pango_lineage", "clade_membership" ], "genome_annotations": { "E": { "end": 26472, "seqid": "defaults/reference_seq.gb", "start": 26245, "strand": "+", "type": "CDS" }, "M": { "end": 27191, "seqid": "defaults/reference_seq.gb", "start": 26523, "strand": "+", "type": "CDS" }, "N": { "end": 29533, "seqid": "defaults/reference_seq.gb", "start": 28274, "strand": "+", "type": "CDS" }, "ORF1a": { "end": 13468, "seqid": "defaults/reference_seq.gb", "start": 266, "strand": "+", "type": "CDS" }, "ORF1b": { "end": 21555, "seqid": "defaults/reference_seq.gb", "start": 13468, "strand": "+", 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{ "latitude": 30.451098, "longitude": 86.654576 }, "Europe": { "latitude": 49.646237, "longitude": 10.799454 }, "North America": { "latitude": 28.2367447, "longitude": -97.738017 }, "Oceania": { "latitude": -25.0562891, "longitude": 152.008576 }, "South America": { "latitude": -13.083583, "longitude": -58.470721 } }, "key": "region" } ], "maintainers": [ { "name": "Ivan Aksamentov", "url": "https://neherlab.org" }, { "name": "Richard Neher", "url": "https://neherlab.org" } ], "panels": [ "tree" ], "title": "SARS-CoV-2 phylogeny", "updated": "2021-07-08" }, "tree": { "branch_attrs": { "labels": { "clade": "19A" }, "mutations": {} }, "children": [ { "branch_attrs": { "mutations": {} }, "name": "Wuhan-Hu-1/2019", "node_attrs": { "author": { "author": "Wu et al", "title": "Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome", "value": "Wu et al" }, "clade_membership": { "value": "19A" }, "country": { "confidence": { "China": 1.0 }, "entropy": 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"region": { "value": "North America" }, "region_exposure": { "value": "North America" }, "url": "https://www.ncbi.nlm.nih.gov/nuccore/MW065351" } }, { "branch_attrs": { "mutations": {} }, "name": "CHN/Wuhan_IME-WH02/2019", "node_attrs": { "author": { "author": "Fan et al", "title": "Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/CHN/Wuhan_IME-WH02/2019, complete genome", "value": "Fan et al" }, "clade_membership": { "value": "19A" }, "country": { "confidence": { "China": 1.0 }, "entropy": -1.000088900581841e-12, "value": "China" }, "div": 0, "division": { "value": "Hubei" }, "pango_lineage": { "value": "B" }, "region": { "value": "Asia" }, "region_exposure": { "value": "Asia" }, "url": "https://www.ncbi.nlm.nih.gov/nuccore/MT291827" } }, { "branch_attrs": { "labels": { "aa": "ORF1a: H3233Y; ORF3a: G251V; S: L8V" }, "mutations": { "ORF1a": [ "H3233Y" ], "ORF3a": [ "G251V" ], "S": [ "L8V" ], "nuc": [ "C9962T", "T13929C", "C14724T", "T21584G", "G26144T" ] } }, 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Q1918-, P1919-, Y1920-, P1921-, N1922-, A1923-, S1924-, F1925-, D1926-, N1927-, F1928S, F1930Q, V1931I, D1933*, N1934*, I1935F, F1937P, A1938V, D1939N, D1940W, N1942-, Q1943*, L1944E, G1946C, Y1947F, K1949R, P1950A, A1951*, R1953-, E1954-, L1955-, K1956-, V1957-, T1958Y, F1959I, D1962*, N1964-, G1965-, D1966-, V1967-, V1968-, A1969-, I1970-, D1971-, Y1972-, H1974-, Y1975-, T1976-, P1977-, S1978-, F1979-, K1980-, K1981-, G1982-, A1983-, K1984-, L1985-, L1986-, H1987-, K1988-, P1989*, W1992S, N1995-, N1996-, A1997-, T1998-, N1999-, K2000-, A2001-, T2002-, Y2003-, K2004-, P2005-, N2006-, T2007-, W2008-, C2009*, I2010T, R2011K, C2012Y, W2014V, S2015Y, K2017L, P2018S, V2019L, S2024I, F2025K, D2026F, L2028*, K2029C, S2030T, D2032V, A2033R, Q2034G, G2035R, M2036A, D2037G, A2040*, C2041R, E2042S, D2043S, L2044G, P2046-, V2047-, S2048-, E2049-, E2050-, V2051-, V2052-, E2053-, N2054-, P2055-, T2056-, I2057-, Q2058-, K2059-, D2060-, V2061-, L2062-, E2063-, C2064-, N2065S, V2066Y, K2067H, E2070-, V2071-, V2072-, G2073-, D2074-, I2075-, I2076-, L2077-, K2078-, P2079-, A2080-, N2081-, N2082-, S2083-, L2084-, K2085-, I2086*, E2088-, E2089-, V2090-, G2091-, H2092-, T2093-, D2094-, L2095-, M2096-, A2097-, A2098-, Y2099-, V2100-, D2101-, S2103G, S2104C, T2106S, K2108-, K2109-, P2110-, N2111-, E2112-, L2113-, S2114-, R2115-, V2116-, L2117-, G2118-, L2119-, K2120-, T2121-, L2122-, A2123-, T2124-, H2125-, G2126-, L2127-, A2128R, A2129F, V2130E, V2133-, P2134-, W2135-, D2136-, T2137-, I2138-, A2139-, N2140-, Y2141-, A2142-, K2143-, P2144-, F2145*, K2148Y, V2149*, V2150H, T2152Y, T2154-, N2155-, I2156V, V2157F, T2158K, R2159P, N2162-, R2163-, V2164-, C2165-, T2166-, N2167-, Y2168-, M2169-, P2170-, Y2171-, F2172-, F2173-, T2174Y, L2175*, L2177Y, Q2178A, C2180F, T2181L, F2182Y, T2183F, R2184I, S2185A, S2188*, R2189S, K2191Y, M2194-, P2195-, T2196-, T2197-, I2198-, A2199-, K2200-, N2201-, T2202-, V2203-, K2204-, S2205-, V2206-, G2207-, C2210E, L2211V, E2212T, A2213*, S2214F, N2216*, Y2217T, L2218D, S2220Y, P2221Y, F2223L, S2224V, K2225F, L2226T, N2228K, I2229C, I2230L, I2231P, W2232R, L2234F, L2235N, S2237-, V2238-, C2239-, L2240-, G2241-, S2242-, L2243-, I2244-, Y2245-, S2246-, T2247-, A2248-, A2249-, L2250-, G2251-, V2252-, L2253-, M2254-, S2255L, G2258-, M2259-, P2260-, S2261-, Y2262-, C2263-, T2264-, G2265-, Y2266-, R2267-, E2268-, G2269-, N2272L, S2273Y, T2274W, N2275F, V2276Y, I2278-, A2279-, T2280-, Y2281-, C2282-, T2283-, G2284-, S2285-, I2286-, P2287-, C2288-, S2289L, V2290*, G2294H, D2296-, S2297-, L2298-, D2299-, T2300-, Y2301-, P2302-, S2303-, L2304-, E2305-, T2306-, I2307-, Q2308-, I2309-, T2310-, I2311-, S2313F, K2315F, D2317-, L2318-, T2319-, A2320-, F2321-, G2322-, L2323-, V2324-, A2325-, E2326-, W2327-, F2328-, L2329-, A2330-, Y2331-, I2332-, F2334S, T2335C, F2338H, Y2339*, L2341C, G2342N, L2343H, A2345I, I2346V, M2347F, F2351C, Y2353T, A2355Y, V2356*, H2357*, I2359-, S2360-, N2361-, S2362-, W2363-, L2364-, M2365-, W2366-, L2367-, I2368-, I2369-, N2370-, V2372-, Q2373-, M2374-, A2375-, P2376-, I2377-, S2378-, A2379-, M2380-, V2381-, R2382-, M2383-, Y2384-, I2385-, F2386-, A2388S, S2389Y, F2390G, Y2391*, Y2392N, W2394R, K2395L, S2396*, Y2397F, V2398I, H2399N, V2400L, V2401Y, G2403-, C2404-, N2405-, S2406-, S2407-, T2408-, C2409-, M2410-, M2411-, C2412-, Y2413-, K2414-, R2415-, N2416-, R2417-, A2418-, T2419-, R2420-, E2422L, C2423Q, T2425*, I2426*, V2427S, G2429K, V2430S, R2432M, S2433Y, F2434N, V2436L, Y2437L, A2438Q, N2439T, G2440T, G2441Q, K2442L, G2443E, F2444L, K2446*, H2448-, N2449-, W2450-, N2451-, C2452-, V2453-, N2454-, C2455-, D2456-, T2457-, F2458-, C2459-, A2460-, G2461-, S2462-, T2463*, F2464Y, D2467C, A2470-, R2471-, D2472-, L2473-, S2474-, L2475-, Q2476-, F2477-, K2478-, R2479-, P2480-, I2481-, N2482*, P2483K, D2485N, Q2486K, S2488Y, Y2489*, I2490P, D2492P, V2494L, T2495L, V2496*, K2497*, N2498S, G2499W, I2501-, H2502-, L2503-, Y2504-, F2505-, D2506-, A2508D, G2509L, Q2510*, Y2513-, E2514-, R2515-, H2516F, H2520-, F2521-, V2522-, N2523-, L2524F, D2525C, N2526*, N2530-, N2531-, T2532-, K2533-, G2534-, S2535-, L2536-, P2537-, I2538-, N2539-, V2540-, I2541-, V2542-, F2543-, D2544-, G2545-, K2546-, K2548V, E2550L, E2551L, S2552Q, K2555-, S2556-, A2557-, S2558-, V2559-, Y2561V, Q2563-, L2564-, M2565-, C2566-, Q2567-, P2568-, I2569-, L2570-, L2571-, L2572-, D2573-, Q2574T, A2575Y, L2576T, S2578T, D2579R, V2580S, D2582I, A2584-, E2585-, V2586-, A2587-, K2589Y, M2590V, D2592I, A2593N, Y2594F, V2595*, N2596R, F2598N, S2599G, S2600K, F2602Q, V2604-, P2605-, M2606-, E2607-, K2608-, L2609-, K2610-, T2611-, L2612-, V2613-, A2614-, A2616K, A2618-, E2619-, L2620-, A2621-, K2622-, N2623-, V2624-, S2625-, L2626-, D2627-, N2628C, S2631F, T2632Y, I2634S, A2636S, Q2639-, G2640-, F2641-, V2642-, D2643-, S2644-, D2645-, V2646-, E2647-, T2648-, K2649-, D2650-, V2652-, E2653-, C2654-, L2655-, K2656-, L2657-, S2658-, H2659-, Q2660-, S2661-, D2662-, I2663-, E2664-, G2667S, D2668I, S2669*, C2670H, N2671R, N2672S, M2674-, L2675-, T2676-, Y2677-, N2678-, K2679-, V2680-, E2681-, N2682-, M2683D, R2686*, D2687P, L2688W, G2689C, A2690L, C2691Y, I2692*, D2693L, C2694*, S2695C, R2697S, H2698Y, I2699*, N2700C, Q2702G, V2703S, A2704K, H2707-, N2708-, I2709-, A2710-, L2711-, I2712-, W2713-, N2714-, V2715-, K2716-, D2717Q, F2718H, M2719C, S2720F, L2721D, S2722M, Q2724R, L2725*, Q2728-, I2729-, R2730-, S2731-, A2732-, A2733-, K2734-, K2735-, N2736-, N2737-, L2738-, P2739-, F2740E, K2741*, A2745-, T2746-, T2747-, R2748-, Q2749-, V2750-, V2751-, N2752-, V2753-, V2754-, T2755-, T2756-, K2757-, I2758-, A2759-, L2760-, K2761-, G2762N, G2763N, I2765A, N2768-, W2769-, L2770-, K2771-, Q2772-, L2773-, I2774*, K2775S, V2776Y, L2778C, V2783-, A2784-, A2785-, I2786-, F2787-, Y2788-, L2789-, I2790-, T2791-, P2792-, V2793-, H2794-, V2795-, M2796-, S2797-, K2798-, H2799-, T2800N, D2801N, F2802T, S2803C, E2805R, I2807Q, K2810-, A2811-, I2812-, D2813-, G2814-, G2815-, V2816-, T2817-, R2818-, D2819-, I2820-, A2821-, S2822-, T2823*, D2824Q, F2827*, A2828F, N2829*, K2830H, H2831M, A2832V, D2833*, F2834P, D2835A, T2836W, F2838*, S2839L, Q2840Y, R2841*, G2842*, G2843Q, Y2845L, T2846P, N2847I, K2849-, A2850-, C2851-, P2852-, L2853-, I2854-, A2855-, A2856-, V2857-, I2858-, T2859-, R2860-, E2861-, V2862-, V2865-, V2866-, P2867-, G2868-, L2869-, P2870-, G2871-, T2872-, I2873-, L2874C, T2877H, G2879*, D2880W, F2881*, H2883A, P2886T, R2887*, V2888S, S2890-, A2891-, V2892-, G2893-, N2894-, I2895*, T2898R, P2899V, S2900H, K2901*, I2903-, E2904-, Y2905-, T2906-, D2907-, F2908-, A2909-, T2910-, S2911-, A2912-, C2913-, V2914-, L2915-, A2916-, A2917-, E2918-, T2920N, K2923W, D2924*, G2927-, K2928-, P2929-, V2930-, P2931-, Y2932-, C2933-, Y2934-, D2935-, N2937I, V2938L, E2940-, G2941-, S2942-, V2943-, A2944*, E2946Q, S2947C, L2948T, P2950-, D2951-, T2952-, R2953-, Y2954-, V2955-, L2956-, M2957-, D2958-, G2959-, S2960-, I2961-, I2962-, Q2963-, F2964-, P2965-, N2966-, T2967-, Y2968-, E2970Y, G2971Y, R2974-, V2975-, V2976-, T2977-, T2978-, F2979-, D2980-, S2981-, E2982L, Y2983*, C2984A, G2987L, T2988*, C2989K, E2990I, E2993-, A2994-, G2995-, V2996-, C2997-, V2998-, S2999-, T3000-, S3001-, G3002-, R3003-, V3005*, N3007L, N3008Q, D3009I, Y3010F, Y3011T, L3014-, P3015-, G3016-, V3017-, F3018-, C3019-, G3020-, V3021-, D3022-, A3023-, V3024-, N3025-, L3026F, M3030-, F3031-, T3032-, P3033-, L3034-, I3035-, Q3036-, P3037-, I3038-, G3039-, A3040-, L3041-, D3042-, I3043-, A3045T, S3046Y, I3047W, V3048C, A3049F, G3051H, V3053Y, A3054R, I3055S, V3056N, V3057M, T3058P, A3061-, Y3062-, Y3063-, F3064-, M3065-, R3066-, F3067-, R3068-, R3069-, A3070L, G3072Y, S3075-, H3076-, V3077-, V3078-, A3079-, F3080-, N3081-, T3082-, L3083-, L3084-, F3085-, L3086-, M3087-, S3088-, V3091L, C3093I, P3096-, V3097-, Y3098-, S3099-, F3100-, L3101-, P3102-, G3103-, V3104-, Y3105-, S3106-, V3107-, I3108-, Y3109-, L3110W, Y3111C, T3113F, F3114C, N3118Y, D3119S, S3121D, F3122G, L3123Y, A3124V, I3126-, Q3127-, W3128-, M3129-, V3130-, M3131-, F3132-, T3133-, P3134-, L3135-, V3136-, P3137-, F3138-, W3139-, I3140-, I3142K, Y3144-, I3145-, I3146-, C3147-, I3148-, S3149-, T3150-, K3151-, H3152-, F3153-, Y3154-, W3155-, F3156-, F3157-, S3158-, N3159-, Y3160-, L3161-, K3162-, R3163F, R3164L, V3165L, F3167L, N3168*, G3169*, V3170L, S3171P, F3172K, S3173E, E3176-, E3177-, A3178-, A3179-, L3180-, C3181-, T3182-, F3183-, L3184-, L3185-, N3186-, K3187-, E3188-, M3189-, Y3190-, L3191V, L3193*, D3196-, V3197-, L3198-, L3199-, P3200-, L3201-, T3202-, Q3203-, Y3204-, N3205-, R3206-, Y3207-, L3208-, A3209-, L3210-, K3213G, K3215-, Y3216-, F3217-, S3218-, G3219-, A3220-, M3221-, D3222-, T3223-, T3224-, S3225-, Y3226-, R3227-, E3228-, A3229-, A3230-, C3231-, C3232N, H3233*, A3235Q, K3236R, A3237S, L3238C, N3239L, D3240L, F3241S, N3243R, S3244K, D3247T, V3248N, Q3251-, P3252-, P3253-, Q3254-, T3255-, S3256-, I3257-, T3258-, S3259-, A3260-, V3261-, L3262H, Q3263L, G3265W, R3267*, M3269N, A3270G, F3271I, G3274-, K3275-, V3276-, E3277-, G3278-, C3279-, M3280-, V3281-, Q3282-, V3283-, T3284-, C3285-, G3286-, T3287-, T3288-, T3289-, L3290-, N3291-, G3292N, D3296-, D3297-, V3298-, V3299-, Y3300-, C3301-, P3302-, R3303-, H3304-, V3305-, I3306S, C3307K, S3309C, E3310D, D3311L, M3312H, N3314*, P3315R, N3316H, Y3317A, E3318*, D3319P, L3320*, I3322*, K3324-, S3325-, N3326-, H3327-, N3328-, F3329-, L3330-, V3331-, Q3332-, A3333-, G3334-, N3335-, V3336-, Q3337-, L3338-, R3339-, V3340-, I3341W, G3342*, H3343C, M3345T, N3347T, C3348F, V3349Y, L3350A, K3353*, D3355*, T3356V, A3357C, N3358S, P3359H, K3360S, P3362R, K3363T, Y3364D, K3365F, V3367-, R3368-, I3369-, Q3370-, P3371-, G3372-, Q3373-, T3374-, F3375-, S3376-, V3377-, L3378-, A3379-, C3380-, Y3381-, N3382-, G3383-, P3385V, G3387F, V3388H, Q3390-, C3391-, A3392-, M3393-, R3394-, P3395-, N3396-, F3397-, T3398-, I3399-, K3400-, G3401-, S3402-, F3403-, L3404-, N3405-, G3406-, S3407-, C3408*, S3410L, V3411C, G3412L, N3414-, I3415-, D3416-, Y3417-, D3418-, C3419-, V3420-, S3421-, F3422-, C3423-, Y3424-, M3425-, H3426-, H3427-, M3428-, E3429-, L3430-, P3431-, T3432-, G3433L, V3434L, G3437W, D3439-, L3440-, E3441-, G3442-, N3443-, F3444-, Y3445-, G3446-, P3447-, F3448-, V3449-, D3450-, R3451-, Q3452F, T3453C, A3454*, A3457N, G3458S, D3460S, T3461S, T3462W, I3463Y, T3464G, V3465H, V3467Y, L3468Y, A3469S, W3470*, L3471C, Y3472F, A3473S, A3474L, N3477-, G3478-, D3479-, R3480-, W3481-, F3482-, L3483-, N3484-, R3485-, F3486-, T3487-, T3488-, T3489Y, L3490H, D3492S, F3493*, N3494*, V3496*, A3497P, M3498C, K3499G, Y3502T, E3503R, L3505-, T3506-, Q3507-, D3508-, H3509-, V3510-, D3511-, I3512-, L3513-, G3514-, P3515-, L3516-, S3517C, A3518*, Q3519H, G3521F, A3523-, V3524-, L3525-, D3526-, M3527-, C3528-, A3529-, S3530-, L3531-, K3532-, E3533-, L3534-, L3535-, Q3536-, N3537-, G3538-, M3539-, N3540-, G3541K, T3543F, L3545-, G3546-, S3547-, A3548-, L3549-, L3550-, E3551-, D3552-, E3553-, F3554-, T3555-, P3556-, F3557-, D3558-, V3559-, V3560-, Q3562K, G3565E, V3566K, T3567N, F3568N, S3570-, A3571-, V3572-, K3573-, R3574-, T3575-, I3576-, K3577-, G3578-, T3579-, H3580-, H3581-, W3582-, L3583-, L3584-, L3585-, T3586-, I3587G, L3588Y, S3590P, L3592F, V3595-, Q3596-, S3597-, T3598-, Q3599-, W3600-, S3601-, L3602-, F3603-, F3604-, Q3777H, T4249I; ORF7b: C41F" }, "mutations": { "ORF1a": [ "G519-", "A520-", "W521-", "N522-", "I523-", "G524-", "E525-", "Q526V", "K527P", "S528G", "S531R", "P532L", "Y534-", "A535-", "F536-", "A537-", "S538-", "E539-", "A540-", "A541-", "R542-", "V543-", "V544-", "R545-", "S546-", "I547-", "F548-", "S549-", "R550-", "T551-", "L552V", "E553L", "T554Y", "A555D", "N557F", "V559R", "V561P", "Q563-", "K564-", "A565-", "A566-", "I567-", "T568-", "I569-", "L570-", "D571-", "G572-", "I573-", "S574*", "R579H", "D582-", "A583-", "M584-", "M585-", "F586-", "T587-", "S588-", "D589W", "A591L", "N593I", "N594*", "V596-", "V597-", "M598-", "A599*", "Y600W", "I601P", "G603L", "G604Q", "Q607*", "Q611-", "W612-", "L613-", "T614-", "N615-", "I616-", "F617-", "G618-", "T619-", "V620-", "Y621-", "E622-", "K623-", "K625N", "V627S", "D629I", "W630G", "E632V", "E633*", "K634S", "K636L", "G638T", "E640G", "F641K", "R643L", "D644N", "G645L", "W646S", "E647Q", "I648P", "K650-", "F651-", "I652-", "S653-", "T654-", "C655-", "A656-", "C657-", "E658-", "I659-", "V660-", "G661-", "G662-", "Q663-", "I664L", "T666K", "C667L", "A668S", "K669V", "E670D", "I671K", "K672L", "E673S", "S674P", "T677I", "F678N", "K680W", "V682C", "N683V", "K684L", "F685T", "A687S", "C689-", "A690-", "D691-", "S692-", "I693-", "I694-", "I695-", "G696-", "G697-", "A698-", "K699-", "K701V", "A702E", "G706P", "E707*", "T708I", "F709*", "T711K", "S713L", "K714S", "G715R", "L716T", "Y717Q", "K719D", "V721T", "K722E", "R724-", "E725-", "E726-", "T727-", "G728-", "L729V", "M731N", "K734S", "A735S", "P736*", "K737R", "I739K", "I740H", "L742-", "E743-", "G744-", "E745-", "T746-", "L747-", "P748-", "T749-", "E750-", "V751-", "L752-", "T753-", "E754-", "E755-", "V756-", "V757P", "L758Q", "T760N", "G761N", 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A1049L, V1052G, P1054-, T1055-, V1056-, V1057-, V1058-, N1059-, A1060-, A1061T, V1063R, Y1064S, H1067*, G1069Y, G1070*, V1071Q, A1072C, G1073H, L1075-, N1076-, K1077-, A1078-, T1079-, N1080-, N1081-, A1082-, M1083-, Q1084-, V1085-, E1086-, S1087-, D1088-, D1089-, Y1090-, I1091-, A1092S, T1093*, N1094I, G1095*, P1096*, V1099R, G1100T, G1101Q, V1104T, G1107S, H1108C, N1109C, L1110R, A1111P, H1113-, C1114-, L1115-, H1116-, V1117-, V1118-, G1119-, P1120-, N1121-, V1122-, N1123-, K1124-, G1125-, E1126-, D1127C, I1128*, L1131*, S1133-, A1134-, Y1135-, E1136-, N1137-, F1138-, N1139-, Q1140-, H1141-, E1142-, V1143-, L1144-, L1145-, A1146-, P1147-, L1148F, L1149*, G1152R, I1153S, F1154S, G1155T, A1156C, D1157T, P1158I, H1160I, L1162C, V1164Y, V1166-, D1167-, T1168-, V1169-, R1170-, T1171-, N1172-, V1173-, Y1174-, L1175-, A1176-, V1177-, F1178S, D1179H, N1181C, Y1183L, D1184S, K1185C, V1187*, S1188*, S1189K, F1190S, M1193*, S1195-, E1196-, K1197-, Q1198-, V1199-, E1200-, Q1201-, K1202-, I1203-, E1205A, P1207Y, K1208N, E1209*, E1210K, V1211*, K1212T, P1213F, F1214S, I1215*, S1218-, K1219-, P1220-, S1221-, V1222-, E1223-, Q1224-, R1225-, K1226-, Q1227-, D1228-, D1229-, K1230-, K1231-, I1232-, A1234T, C1235R, V1236*, E1237*, T1240P, T1241H, T1242R, L1243K, E1244L, E1245V, K1247-, F1248-, L1249-, T1250-, E1251-, N1252-, L1253-, L1254-, L1255-, Y1256-, I1257-, D1258-, I1259-, N1260-, G1261-, N1262-, P1265-, D1266-, S1267-, A1268-, T1269-, L1270-, V1271-, S1272-, D1273-, I1274-, D1275*, I1276H, T1277H, K1281E, D1282R, A1283C, P1284S, Y1285I, I1286Y, V1287S, D1289*, V1290C, V1291C, Q1292S, E1293R, V1295-, L1296-, T1297-, A1298-, V1299-, V1300-, I1301-, P1302-, T1303C, K1304F, K1305N, A1306C, G1307C, T1309Y, M1312K, L1313S, K1315-, A1316-, L1317-, R1318-, K1319-, V1320-, P1321-, T1322-, D1323-, N1324-, Y1325-, I1326-, T1327-, T1328-, Y1329-, P1330N, G1331R, G1333L, L1334Y, Y1337-, T1338-, V1339-, E1340-, E1341-, A1342-, K1343-, T1344-, V1345-, L1346-, K1347-, K1348-, C1349-, A1352T, F1353I, I1355Y, P1357*, S1358*, I1359E, I1360A, S1361R, E1363-, K1364-, Q1365-, E1366-, I1367-, L1368-, G1369-, T1370-, V1371-, L1375C, R1376F, E1377L, M1378E, L1379F, H1381R, A1382N, E1383A, E1384C, R1386-, K1387-, L1388-, M1389-, P1390-, V1391-, V1393N, E1394Y, K1396A, A1397*, V1399-, S1400-, T1401-, I1402-, Q1403-, R1404-, K1405-, Y1406-, K1407-, G1408-, I1409-, K1410-, I1411-, Q1412-, E1413*, V1415-, V1416-, D1417-, Y1418-, G1419-, A1420-, R1421-, F1422-, Y1423-, F1424-, Y1425-, T1426-, S1427-, K1428-, T1429-, T1430-, V1431-, A1432-, S1433-, I1435L, N1436H, T1437Q, L1438*, D1440N, L1441C, N1442S, E1443V, V1446C, T1447N, M1448T, P1449W, G1451-, Y1452-, V1453-, T1454-, H1455-, G1456-, L1457-, N1458-, L1459-, E1460-, E1461-, A1462-, A1463-, R1464K, Y1465F, M1466G, L1469C, K1470S, P1472*, A1473C, T1474C, V1475Y, S1478*, S1479W, P1480L, D1481S, A1482Y, V1483F, T1484F, A1485F, Y1486*, G1488T, Y1489*, L1490R, S1492F, S1493Y, S1494*, K1495N, T1496H, P1497L, E1498T, E1499C, H1500W, I1502L, E1503*, T1504R, I1505L, S1506V, A1508-, G1509-, S1510-, Y1511-, K1512-, D1513-, W1514-, S1515-, Y1516-, S1517-, G1518-, Q1519-, S1520-, T1521-, Q1522-, L1523-, G1524-, I1525-, E1526-, K1529-, R1530-, G1531-, D1532-, K1533-, S1534-, V1535-, Y1536-, Y1537-, T1538-, S1539-, N1540-, P1541-, T1542-, T1543-, F1544-, L1546*, D1547*, G1548S, E1549Y, V1550H, T1552S, D1554-, N1555-, L1556-, K1557-, T1558-, L1559-, L1560-, S1561-, L1562-, R1563-, E1564-, V1565-, R1566-, T1567-, I1568-, K1569-, V1570-, T1572*, T1573G, D1575Y, I1577S, N1578R, L1579Q, T1581G, Q1582H, V1584N, M1586I, S1587W, M1588T, Y1590-, G1591-, Q1592-, Q1593-, F1594-, G1595-, P1596-, T1597-, Y1598-, L1599-, D1600-, G1601-, A1602-, D1603-, T1605-, K1606-, I1607-, K1608-, P1609-, H1610-, N1611-, S1612-, H1613-, E1614-, G1615-, F1618-, Y1619-, V1620-, L1621-, P1622-, N1623-, D1624-, D1625-, T1626-, L1627-, R1628-, V1629-, E1630-, A1631-, F1632-, E1633-, Y1634-, Y1635-, T1637S, D1639C, P1640*, S1641G, L1643G, G1644*, R1645V, Y1646H, M1647V, A1649I, L1650K, N1651S, T1653*, K1655-, W1656-, K1657-, Y1658-, P1659-, Q1660-, N1662E, G1663I, L1664P, I1667-, K1668-, W1669-, A1670-, D1671-, N1672-, N1673-, C1674-, Y1675-, L1676-, A1677-, T1678-, A1679-, T1682S, L1683C, Q1684H, Q1685C, E1687-, L1688-, K1689-, F1690V, P1692T, A1694L, D1697-, A1698-, Y1699-, Y1700-, R1701-, A1702-, R1703-, A1704-, G1705S, E1706K, A1707G, A1708W, N1709*, F1710S, A1712*, I1714L, L1715C, A1716T, C1718*, N1719C, K1720*, T1721R, V1722N, G1723N, G1726-, D1727-, V1728-, R1729-, E1730-, T1731-, M1732-, S1733-, Y1734-, L1735-, F1736-, Q1737-, H1738-, A1739-, N1740-, D1742V, C1744E, K1745R, R1746G, L1748*, V1750-, V1751-, C1752-, K1753-, T1754-, C1755-, G1756-, Q1757-, Q1758L, Q1759W, L1762-, K1763-, G1764-, V1765-, E1766-, V1768D, M1769N, Y1770P, M1771*, T1773C, L1774R, Y1776-, E1777-, Q1778-, F1779-, K1780-, K1781-, G1782-, V1783-, Q1784-, I1785-, P1786-, C1787-, T1788-, C1789-, G1790-, K1791-, Q1792-, A1793-, K1795C, L1797D, Q1799-, Q1800-, E1801-, S1802-, P1803-, F1804-, V1805-, M1806-, M1807-, S1808-, A1809-, P1810-, P1811-, A1812-, Q1813-, Y1814-, E1815-, L1816-, K1817-, H1818-, G1819S, F1821*, C1823*, E1826L, Y1827*, G1829Y, Y1831-, Q1832-, C1833-, G1834-, H1835-, Y1836-, K1837-, H1838-, I1839-, T1840-, S1841-, K1842-, E1843-, T1844-, L1845-, Y1846F, C1847*, I1848R, D1849N, G1850F, A1851V, L1853H, T1854R, K1855R, S1856C, S1857F, E1858T, G1861-, P1862-, I1863-, T1864-, D1865-, F1867L, Y1868R, K1869I, E1870Q, N1871R, T1875-, T1876-, I1877-, K1878-, P1879-, V1880-, T1881S, K1883L, L1884*, D1885I, V1887W, V1888C, T1890-, E1891-, I1892-, D1893-, P1894-, K1895-, L1896-, D1897-, N1898-, Y1899L, K1901R, K1902A, D1903T, S1905*, Y1906S, F1907C, E1909K, Q1910P, P1911T, D1913-, L1914-, V1915-, P1916-, N1917-, Q1918-, P1919-, Y1920-, P1921-, N1922-, A1923-, S1924-, F1925-, D1926-, N1927-, F1928S, F1930Q, V1931I, D1933*, N1934*, I1935F, F1937P, A1938V, D1939N, D1940W, N1942-, Q1943*, L1944E, G1946C, Y1947F, K1949R, P1950A, A1951*, R1953-, E1954-, L1955-, K1956-, V1957-, T1958Y, F1959I, D1962*, N1964-, G1965-, D1966-, V1967-, V1968-, A1969-, I1970-, D1971-, Y1972-, H1974-, Y1975-, T1976-, P1977-, S1978-, F1979-, K1980-, K1981-, G1982-, A1983-, K1984-, L1985-, L1986-, H1987-, K1988-, P1989*, W1992S, N1995-, N1996-, A1997-, T1998-, N1999-, K2000-, A2001-, T2002-, Y2003-, K2004-, P2005-, N2006-, T2007-, W2008-, C2009*, I2010T, R2011K, C2012Y, W2014V, S2015Y, K2017L, P2018S, V2019L, S2024I, F2025K, D2026F, L2028*, K2029C, S2030T, D2032V, A2033R, Q2034G, G2035R, M2036A, D2037G, A2040*, C2041R, E2042S, D2043S, L2044G, P2046-, V2047-, S2048-, E2049-, E2050-, V2051-, V2052-, E2053-, N2054-, P2055-, T2056-, I2057-, Q2058-, K2059-, D2060-, V2061-, L2062-, E2063-, C2064-, N2065S, V2066Y, K2067H, E2070-, V2071-, V2072-, G2073-, D2074-, I2075-, I2076-, L2077-, K2078-, P2079-, A2080-, N2081-, N2082-, S2083-, L2084-, K2085-, I2086*, E2088-, E2089-, V2090-, G2091-, H2092-, T2093-, D2094-, L2095-, M2096-, A2097-, A2098-, Y2099-, V2100-, D2101-, S2103G, S2104C, T2106S, K2108-, K2109-, P2110-, N2111-, E2112-, L2113-, S2114-, R2115-, V2116-, L2117-, G2118-, L2119-, K2120-, T2121-, L2122-, A2123-, T2124-, H2125-, G2126-, L2127-, A2128R, A2129F, V2130E, V2133-, P2134-, W2135-, D2136-, T2137-, I2138-, A2139-, N2140-, Y2141-, A2142-, K2143-, P2144-, F2145*, K2148Y, V2149*, V2150H, T2152Y, T2154-, N2155-, I2156V, V2157F, T2158K, R2159P, N2162-, R2163-, V2164-, C2165-, T2166-, N2167-, Y2168-, M2169-, P2170-, Y2171-, F2172-, F2173-, T2174Y, L2175*, L2177Y, Q2178A, C2180F, T2181L, F2182Y, T2183F, R2184I, S2185A, S2188*, R2189S, K2191Y, M2194-, P2195-, T2196-, T2197-, I2198-, A2199-, K2200-, N2201-, T2202-, V2203-, K2204-, S2205-, V2206-, G2207-, C2210E, L2211V, E2212T, A2213*, S2214F, N2216*, Y2217T, L2218D, S2220Y, P2221Y, F2223L, S2224V, K2225F, L2226T, N2228K, I2229C, I2230L, I2231P, W2232R, L2234F, L2235N, S2237-, V2238-, C2239-, L2240-, G2241-, S2242-, L2243-, I2244-, Y2245-, S2246-, T2247-, A2248-, A2249-, L2250-, G2251-, V2252-, L2253-, M2254-, S2255L, G2258-, M2259-, P2260-, S2261-, Y2262-, C2263-, T2264-, G2265-, Y2266-, R2267-, E2268-, G2269-, N2272L, S2273Y, T2274W, N2275F, V2276Y, I2278-, A2279-, T2280-, Y2281-, C2282-, T2283-, G2284-, S2285-, I2286-, P2287-, C2288-, S2289L, V2290*, G2294H, D2296-, S2297-, L2298-, D2299-, T2300-, Y2301-, P2302-, S2303-, L2304-, E2305-, T2306-, I2307-, Q2308-, I2309-, T2310-, I2311-, S2313F, K2315F, D2317-, L2318-, T2319-, A2320-, F2321-, G2322-, L2323-, V2324-, A2325-, E2326-, W2327-, F2328-, L2329-, A2330-, Y2331-, I2332-, F2334S, T2335C, F2338H, Y2339*, L2341C, G2342N, L2343H, A2345I, I2346V, M2347F, F2351C, Y2353T, A2355Y, V2356*, H2357*, I2359-, S2360-, N2361-, S2362-, W2363-, L2364-, M2365-, W2366-, L2367-, I2368-, I2369-, N2370-, V2372-, Q2373-, M2374-, A2375-, P2376-, I2377-, S2378-, A2379-, M2380-, V2381-, R2382-, M2383-, Y2384-, I2385-, F2386-, A2388S, S2389Y, F2390G, Y2391*, Y2392N, W2394R, K2395L, S2396*, Y2397F, V2398I, H2399N, V2400L, V2401Y, G2403-, C2404-, N2405-, S2406-, S2407-, T2408-, C2409-, M2410-, M2411-, C2412-, Y2413-, K2414-, R2415-, N2416-, R2417-, A2418-, T2419-, R2420-, E2422L, C2423Q, T2425*, I2426*, V2427S, G2429K, V2430S, R2432M, S2433Y, F2434N, V2436L, Y2437L, A2438Q, N2439T, G2440T, G2441Q, K2442L, G2443E, F2444L, K2446*, H2448-, N2449-, W2450-, N2451-, C2452-, V2453-, N2454-, C2455-, D2456-, T2457-, F2458-, C2459-, A2460-, G2461-, S2462-, T2463*, F2464Y, D2467C, A2470-, R2471-, D2472-, L2473-, S2474-, L2475-, Q2476-, F2477-, K2478-, R2479-, P2480-, I2481-, N2482*, P2483K, D2485N, Q2486K, S2488Y, Y2489*, I2490P, D2492P, V2494L, T2495L, V2496*, K2497*, N2498S, G2499W, I2501-, H2502-, L2503-, Y2504-, F2505-, D2506-, A2508D, G2509L, Q2510*, Y2513-, E2514-, R2515-, H2516F, H2520-, F2521-, V2522-, N2523-, L2524F, D2525C, N2526*, N2530-, N2531-, T2532-, K2533-, G2534-, S2535-, L2536-, P2537-, I2538-, N2539-, V2540-, I2541-, V2542-, F2543-, D2544-, G2545-, K2546-, K2548V, E2550L, E2551L, S2552Q, K2555-, S2556-, A2557-, S2558-, V2559-, Y2561V, Q2563-, L2564-, M2565-, C2566-, Q2567-, P2568-, I2569-, L2570-, L2571-, L2572-, D2573-, Q2574T, A2575Y, L2576T, S2578T, D2579R, V2580S, D2582I, A2584-, E2585-, V2586-, A2587-, K2589Y, M2590V, D2592I, A2593N, Y2594F, V2595*, N2596R, F2598N, S2599G, S2600K, F2602Q, V2604-, P2605-, M2606-, E2607-, K2608-, L2609-, K2610-, T2611-, L2612-, V2613-, A2614-, A2616K, A2618-, E2619-, L2620-, A2621-, K2622-, N2623-, V2624-, S2625-, L2626-, D2627-, N2628C, S2631F, T2632Y, I2634S, A2636S, Q2639-, G2640-, F2641-, V2642-, D2643-, S2644-, D2645-, V2646-, E2647-, T2648-, K2649-, D2650-, V2652-, E2653-, C2654-, L2655-, K2656-, L2657-, S2658-, H2659-, Q2660-, S2661-, D2662-, I2663-, E2664-, G2667S, D2668I, S2669*, C2670H, N2671R, N2672S, M2674-, L2675-, T2676-, Y2677-, N2678-, K2679-, V2680-, E2681-, N2682-, M2683D, R2686*, D2687P, L2688W, G2689C, A2690L, C2691Y, I2692*, D2693L, C2694*, S2695C, R2697S, H2698Y, I2699*, N2700C, Q2702G, V2703S, A2704K, H2707-, N2708-, I2709-, A2710-, 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T1328-, Y1329-, P1330N, G1331R, G1333L, L1334Y, Y1337-, T1338-, V1339-, E1340-, E1341-, A1342-, K1343-, T1344-, V1345-, L1346-, K1347-, K1348-, C1349-, A1352T, F1353I, I1355Y, P1357*, S1358*, I1359E, I1360A, S1361R, E1363-, K1364-, Q1365-, E1366-, I1367-, L1368-, G1369-, T1370-, V1371-, L1375C, R1376F, E1377L, M1378E, L1379F, H1381R, A1382N, E1383A, E1384C, R1386-, K1387-, L1388-, M1389-, P1390-, V1391-, V1393N, E1394Y, K1396A, A1397*, V1399-, S1400-, T1401-, I1402-, Q1403-, R1404-, K1405-, Y1406-, K1407-, G1408-, I1409-, K1410-, I1411-, Q1412-, E1413-, G1414-, V1415-, V1416-, D1417-, Y1418*, A1420*, R1421N, F1422N, Y1423C, F1424S, Y1425V, S1427Y, K1428Q, T1429H, V1431*, A1432R, L1434K, I1435*, T1437-, L1438-, N1439-, D1440-, L1441-, N1442-, E1443-, T1444-, L1445-, V1446-, T1447-, M1448-, P1449-, L1450-, G1451-, Y1452-, V1453-, T1454-, H1455-, L1457-, N1458-, L1459-, E1460-, E1461-, A1462-, A1463-, R1464-, Y1465-, M1466-, L1469C, K1470S, P1472C, A1473Y, T1474S, S1476*, V1477W, S1478L, P1480-, D1481-, A1482-, V1483-, T1484-, A1485-, Y1486-, N1487-, G1488-, Y1489-, L1490-, T1491-, S1492-, S1493-, S1494-, K1495-, T1496-, P1497-, E1498Y, E1499F, H1500F, I1502*, E1503N, I1505L, S1506V, A1508-, G1509-, S1510-, Y1511-, K1512-, D1513-, W1514-, S1515-, Y1516-, S1517-, G1518-, Q1519-, S1520-, T1521-, Q1522-, L1523-, G1524-, I1525-, E1526-, K1529-, R1530-, G1531-, D1532-, K1533-, S1534-, V1535-, Y1536-, Y1537-, T1538-, S1539-, N1540-, P1541-, T1542-, T1543-, F1544-, L1546*, D1547*, G1548S, E1549Y, V1550H, T1552S, D1554-, N1555-, L1556-, K1557-, T1558-, L1559-, L1560-, S1561-, L1562-, R1563-, E1564-, V1565-, R1566-, T1567-, I1568-, K1569-, V1570-, T1572*, T1573G, D1575Y, I1577S, N1578R, L1579Q, Q1582T, V1584-, D1585-, M1586-, S1587-, M1588-, T1589-, Y1590-, G1591-, Q1592-, Q1593-, F1594-, G1595-, P1596W, T1597S, Y1598N, D1600F, A1602-, D1603-, V1604-, T1605-, K1606-, I1607-, K1608-, P1609-, H1610-, N1611W, H1613-, E1614-, G1615-, K1616-, T1617-, F1618-, Y1619-, V1620-, L1621-, P1622-, N1623-, D1624-, D1625-, T1626-, L1627-, R1628-, V1629-, E1630-, A1631-, F1632-, E1633-, Y1634*, Y1635*, T1637S, D1639C, P1640*, S1641G, L1643G, G1644*, R1645V, Y1646H, M1647V, A1649I, L1650K, N1651S, T1653*, K1655-, W1656-, K1657-, Y1658-, P1659-, Q1660-, N1662E, G1663I, L1664P, I1667-, K1668-, W1669-, A1670-, D1671-, N1672-, N1673-, C1674-, Y1675-, L1676-, A1677-, T1678-, A1679-, T1682S, L1683C, Q1684H, Q1685C, E1687-, L1688-, K1689-, F1690V, P1692T, A1694L, D1697-, A1698-, Y1699-, Y1700-, R1701-, A1702-, R1703-, A1704-, G1705S, E1706K, A1707G, A1708W, N1709*, F1710S, A1712*, I1714L, L1715C, A1716T, C1718*, N1719C, K1720*, T1721R, V1722N, G1723N, G1726-, D1727-, V1728-, R1729-, E1730-, T1731-, M1732-, S1733-, Y1734-, L1735-, F1736-, Q1737-, H1738-, A1739-, N1740-, D1742V, C1744E, K1745R, R1746G, L1748*, V1750-, V1751-, C1752-, K1753-, T1754-, C1755-, G1756-, Q1757-, Q1758L, Q1759W, L1762-, K1763-, G1764-, V1765-, E1766-, V1768D, M1769N, Y1770P, M1771*, T1773C, L1774R, Y1776-, E1777-, Q1778-, F1779-, K1780-, K1781-, G1782-, V1783-, Q1784-, I1785-, P1786-, C1787-, T1788-, C1789-, G1790-, K1791-, Q1792-, A1793-, K1795C, L1797D, Q1799-, Q1800-, E1801-, S1802-, P1803-, F1804-, V1805-, M1806-, M1807-, S1808-, A1809-, P1810-, P1811-, A1812-, Q1813-, Y1814-, E1815-, L1816-, K1817-, H1818-, G1819-, T1820S, F1821T, A1824W, E1826L, Y1827*, G1829Y, Y1831-, Q1832-, C1833-, G1834-, H1835-, Y1836-, K1837-, H1838-, I1839-, T1840-, S1841-, K1842-, E1843-, T1844-, L1845-, Y1846F, C1847*, I1848R, D1849N, G1850F, A1851V, L1853H, T1854R, K1855R, S1856C, S1857F, E1858T, G1861-, P1862-, I1863-, T1864-, D1865-, F1867L, Y1868R, K1869I, E1870Q, N1871R, T1875-, T1876-, I1877-, K1878-, P1879-, V1880-, T1881S, K1883L, L1884*, D1885I, V1887W, V1888C, T1890-, E1891-, I1892-, D1893-, P1894-, K1895-, L1896-, D1897-, N1898-, Y1899L, K1901R, K1902A, D1903T, S1905*, Y1906S, F1907C, E1909K, Q1910P, P1911T, D1913-, L1914-, V1915-, P1916-, N1917-, Q1918-, P1919-, Y1920-, P1921-, N1922-, A1923-, S1924-, F1925-, D1926-, N1927-, F1928S, V1931K, C1932P, D1933V, I1935-, K1936-, F1937-, A1938-, D1939-, D1940-, L1941-, N1942-, Q1943-, L1944-, T1945-, G1946-, Y1947-, K1948-, K1949-, P1950-, A1951-, S1952-, R1953-, E1954W, K1956*, V1957E, F1959C, P1961Y, D1962*, N1964-, G1965-, D1966-, V1967-, V1968-, A1969-, I1970-, D1971-, Y1972-, K1973-, H1974-, Y1975-, T1976-, P1977-, S1978-, F1979-, K1980-, K1981-, G1982-, A1983-, K1984*, L1985T, K1988S, P1989*, W1992S, N1995-, N1996-, A1997-, T1998-, N1999-, K2000-, A2001-, T2002-, Y2003-, K2004-, P2005-, N2006-, T2007-, W2008-, C2009-, I2010-, R2011-, C2012-, L2013-, W2014-, S2015*, P2018L, E2020Y, S2022*, S2024I, F2025K, D2026F, L2028*, K2029C, S2030T, D2032V, A2033R, Q2034G, G2035R, M2036A, D2037G, A2040*, C2041R, E2042S, D2043S, L2044G, P2046-, V2047-, S2048-, E2049-, E2050-, V2051-, V2052-, E2053-, N2054-, P2055-, T2056-, I2057-, Q2058-, K2059-, D2060-, V2061-, L2062-, E2063-, C2064-, N2065-, V2066S, K2067Y, T2068H, V2071-, V2072-, G2073-, D2074-, I2075-, I2076-, L2077-, K2078-, P2079-, A2080-, N2081-, N2082-, S2083-, L2084-, K2085-, I2086-, E2088-, E2089-, V2090-, G2091-, H2092-, T2093-, D2094-, L2095-, M2096-, A2097-, A2098-, Y2099-, V2100-, D2101-, S2103G, S2104C, T2106S, K2108-, K2109-, P2110-, N2111-, E2112-, L2113-, S2114-, R2115-, V2116-, L2117-, G2118-, L2119-, K2120-, T2121-, L2122-, A2123-, H2125-, G2126-, L2127-, A2128R, A2129F, V2130E, V2133-, P2134-, W2135-, D2136-, T2137-, I2138-, A2139-, N2140-, Y2141-, A2142-, K2143-, P2144-, F2145*, K2148Y, V2149*, V2150H, T2152Y, T2154-, N2155-, I2156-, V2157-, T2158-, R2159-, C2160-, L2161-, N2162-, R2163-, V2164-, C2165-, T2166-, N2167-, Y2168-, M2169-, P2170-, Y2171V, F2173K, T2174P, L2175C, L2177Y, Q2178*, C2180Y, T2181K, T2183-, R2184-, S2185-, T2186*, S2188*, R2189S, K2191Y, M2194-, P2195-, T2196-, T2197-, I2198-, A2199-, K2200-, N2201-, T2202-, V2203-, K2204-, S2205-, V2206-, G2207-, C2210E, L2211V, E2212T, A2213*, S2214F, N2216*, Y2217T, L2218D, S2220Y, P2221Y, F2223L, S2224V, K2225F, L2226T, N2228K, I2229C, I2230L, I2231P, W2232R, L2234F, L2235N, S2237-, V2238-, C2239-, L2240-, G2241-, S2242-, L2243-, I2244-, Y2245-, S2246-, T2247-, A2248-, A2249-, L2250-, G2251-, V2252-, L2253-, M2254-, S2255-, N2256-, G2258N, M2259R, P2260C, S2261F, Y2262R, T2264E, G2265L, R2267*, E2268C, G2269H, L2271C, S2273-, T2274-, N2275-, V2276-, T2277-, I2278-, A2279-, T2280-, Y2281-, C2282-, T2283-, G2284-, S2285-, I2286-, P2287-, C2288-, S2289-, V2290-, G2294H, D2296-, S2297-, L2298-, D2299-, T2300-, Y2301-, P2302-, S2303-, L2304-, E2305-, T2306-, I2307-, Q2308-, I2309-, T2310-, I2311-, S2312-, K2315F, W2316R, D2317N, L2318Y, A2320V, L2323-, V2324-, A2325-, E2326-, W2327-, F2328-, L2329-, A2330-, Y2331-, I2332-, L2333-, F2334-, T2335I, R2336Y, F2337S, Y2339H, V2340*, L2341V, G2342F, A2345I, I2346V, M2347F, F2351C, Y2353T, A2355V, H2357N, F2358N, I2359*, N2361-, S2362-, W2363-, L2364-, M2365-, W2366-, L2367-, I2368-, I2369-, N2370-, L2371-, V2372-, Q2373-, M2374-, A2375-, P2376-, I2377-, S2378-, A2379-, M2380-, V2381-, R2382-, Y2384E, I2385K, F2386L, F2387C, S2389-, F2390-, Y2391-, Y2392-, V2393-, W2394-, K2395-, S2396-, Y2397-, V2398-, H2399-, V2400-, V2401-, D2402-, G2403-, C2404-, N2405-, S2406-, S2407-, T2408-, M2410C, M2411R, C2412R, Y2413L, K2414*, R2415F, N2416I, R2417N, A2418L, T2419Y, R2420D, E2422L, C2423Q, T2425*, I2426*, V2427S, G2429K, V2430S, S2433-, F2434-, Y2435-, V2436-, Y2437-, A2438-, N2439-, G2440-, G2441-, K2442-, G2443-, F2444-, C2445-, K2446-, L2447-, H2448-, N2449-, W2450-, N2451-, C2452-, V2453-, N2454L, C2455L, D2456Q, F2458S, A2460-, G2461-, S2462-, T2463-, F2464-, I2465-, S2466-, D2467-, E2468-, V2469-, A2470-, R2471-, D2472-, L2473-, S2474-, L2475-, Q2476-, F2477-, K2478E, I2481-, N2482-, P2483-, T2484-, D2485-, Q2486-, S2487-, S2488-, Y2489-, I2490-, V2491-, D2492-, S2493-, V2494-, T2495-, K2497F, N2498L, G2499H, S2500R, I2501*, H2502*, L2503C, F2505W, D2506S, A2508D, G2509L, Q2510*, Y2513-, E2514-, R2515-, H2516F, H2520-, F2521-, V2522-, N2523-, L2524F, D2525C, N2526*, N2530-, N2531-, T2532-, K2533-, G2534-, S2535-, L2536-, P2537-, I2538-, N2539-, V2540-, I2541-, V2542-, F2543-, D2544-, G2545-, K2546-, K2548V, E2550-, E2551-, S2552-, S2553-, A2554-, K2555-, S2556-, A2557-, S2558-, V2559-, Y2560-, Y2561-, S2562-, Q2563-, L2564-, M2565-, C2566-, Q2567-, P2568-, I2569-, L2570-, D2573Q, Q2574S, L2576Y, D2579*, V2580*, G2581C, D2582G, A2584C, E2585S, V2586*, A2587N, K2589*, M2590C, F2591L, D2592R, A2593*, N2596R, F2598N, S2599G, S2600K, F2602Q, V2604-, P2605-, M2606-, E2607-, K2608-, L2609-, K2610-, T2611-, L2612-, V2613-, A2614-, A2616K, A2618-, E2619-, L2620-, A2621-, K2622-, N2623-, V2624-, S2625-, L2626-, D2627-, N2628C, S2631F, T2632Y, I2634S, A2636S, Q2639-, G2640-, F2641-, V2642-, D2643-, S2644-, D2645-, V2646-, E2647-, T2648-, K2649-, D2650-, V2651-, E2653R, L2655C, K2656*, L2657M, Q2660R, D2662-, I2663-, E2664-, V2665-, T2666-, G2667-, D2668-, S2669-, C2670-, N2671-, N2672-, Y2673-, M2674-, L2675-, T2676-, N2678*, V2680H, E2681D, N2682T, M2683P, T2684*, R2686W, D2687C, G2689C, C2691S, I2692Y, D2693*, S2695-, A2696-, R2697-, H2698-, I2699-, N2700-, Q2702G, V2703S, A2704K, H2707-, N2708-, I2709-, A2710-, L2711-, I2712-, W2713-, N2714-, V2715-, K2716-, D2717Q, F2718H, M2719C, S2720F, L2721D, S2722M, Q2724R, L2725*, Q2728-, I2729-, R2730-, S2731-, A2732-, A2733-, K2734-, K2735-, N2736-, N2737-, L2738-, P2739-, F2740E, K2741*, A2745-, T2746-, T2747-, R2748-, Q2749-, V2750-, V2751-, N2752-, V2753-, V2754-, T2755-, T2756-, K2757-, I2758-, A2759-, L2760-, K2761-, G2762N, G2763N, I2765A, N2768-, W2769-, L2770-, K2771-, Q2772-, L2773-, I2774*, K2775S, V2776Y, L2778C, V2783-, A2784-, A2785-, I2786-, F2787-, Y2788-, L2789-, I2790-, T2791-, P2792-, V2793-, H2794-, V2795-, M2796-, S2797-, K2798-, H2799-, T2800N, D2801N, F2802T, S2803C, E2805R, I2807Q, K2810-, A2811-, I2812-, D2813-, G2814-, G2815-, V2816-, T2817-, R2818-, D2819-, I2820-, A2821-, S2822-, T2823-, D2824Q, F2827-, A2828-, N2829-, K2830-, H2831-, A2832-, D2833-, F2834-, D2835-, T2836-, W2837-, F2838-, S2839-, Q2840-, R2841-, G2842-, G2843-, Y2845L, T2846P, N2847I, A2850-, C2851-, P2852-, L2853-, I2854-, A2855-, A2856-, V2857-, I2858-, T2859-, R2860-, E2861R, V2862S, V2865-, V2866-, P2867-, G2868-, L2869-, P2870-, G2871-, T2872-, I2873-, L2874C, T2877H, G2879W, D2880*, F2881L, L3123-, A3124*, Q3127-, W3128-, M3129-, V3130-, M3131-, T3133Q, P3134L, V3136-, P3137-, F3138-, W3139-, I3140-, T3141-, I3142-, A3143-, Y3144-, I3145-, I3146-, C3147-, K3151-, H3152-, F3153-, Y3154-, W3155-, F3156-, F3157-, S3158-, N3159-, Y3160-, L3161-, K3162*, R3164D, N3168P, G3169L, S3171-, F3172-, S3173-, T3174-, F3175-, E3176-, E3177-, A3178-, A3179-, L3180-, C3181-, T3182-, F3183-, N3186K, E3188T, M3189S, L3191-, K3192-, L3193-, R3194-, S3195-, D3196-, V3197-, L3198-, L3199-, P3200-, L3201-, T3202-, Q3203-, Y3204-, N3205-, R3206-, Y3207-, L3208-, L3210G, K3213-, Y3214-, K3215-, Y3216-, F3217-, S3218-, G3219-, A3220-, M3221-, D3222-, T3223-, T3224-, S3225-, Y3226-, R3227-, E3228-, A3229-, A3230-, C3231-, C3232-, H3233*, A3235Q, K3236R, A3237S, L3238C, N3239L, D3240L, F3241S, N3243R, S3244K, D3247Q, V3248*, Y3250-, Q3251-, P3252-, P3253-, Q3254-, T3255-, S3256-, I3257-, T3258-, S3259-, A3260-, V3261-, L3262-, Q3263-, S3264-, G3265-, F3266-, R3267-, K3268-, M3269-, A3270-, P3272T, G3274-, K3275-, V3276-, E3277-, G3278-, C3279-, M3280-, V3281-, Q3282-, V3283-, T3284-, C3285-, G3286-, T3287-, T3288-, T3289-, L3290-, N3291-, G3292N, D3296-, D3297-, V3298-, V3299-, Y3300-, C3301-, P3302-, R3303-, H3304-, V3305-, I3306-, C3307-, T3308-, S3309-, E3310-, D3311-, M3312H, N3314*, P3315R, N3316H, Y3317A, E3318*, D3319P, L3320*, I3322*, K3324-, S3325-, N3326-, H3327-, N3328-, F3329-, L3330-, V3331-, Q3332-, A3333-, G3334-, N3335-, V3336-, Q3337-, L3338-, R3339-, V3340-, I3341-, G3342-, H3343C, M3345T, N3347T, C3348F, V3349Y, L3350A, K3353*, D3355C, T3356S, A3357H, N3358S, P3359T, K3360R, P3362-, K3363-, Y3364-, K3365-, F3366-, V3367-, R3368-, I3369-, Q3370-, P3371-, G3372-, Q3373D, T3374F, L3378P, A3379M, N3382-, G3383-, S3384-, P3385-, S3386-, G3387-, V3388-, Y3389-, Q3390-, C3391-, A3392-, M3393-, R3394-, P3395-, N3396-, F3397-, T3398-, I3399-, K3400E, G3401A, S3402Q, L3404R, N3405L, G3406*, S3407L, G3409-, S3410-, V3411-, G3412-, F3413-, N3414-, I3415-, D3416-, Y3417-, D3418-, C3419-, V3420-, S3421-, F3422-, C3423-, Y3424-, M3425-, H3426-, H3427-, M3428-, E3429-, L3430-, P3431L, T3432F, G3433L, V3434L, G3437W, D3439-, L3440-, E3441-, G3442-, N3443-, F3444-, Y3445-, G3446-, P3447-, F3448-, V3449-, D3450-, R3451-, Q3452F, T3453C, A3454*, A3457N, G3458S, D3460S, T3461S, T3462W, I3463Y, T3464G, V3465H, V3467Y, L3468Y, A3469S, W3470*, L3471C, Y3472F, A3473S, A3474L, N3477-, G3478-, D3479-, R3480-, W3481-, F3482-, L3483-, N3484-, R3485-, F3486-, T3487-, T3488-, T3489Y, L3490H, D3492S, F3493*, N3494*, V3496*, A3497P, M3498C, K3499G, Y3502T, E3503R, L3505-, T3506-, Q3507-, D3508-, H3509-, V3510-, D3511-, I3512-, L3513-, G3514-, P3515-, L3516-, S3517C, A3518*, Q3519H, G3521R, A3523-, V3524-, L3525-, D3526-, M3527-, C3528-, A3529-, S3530-, L3531-, K3532-, E3533-, L3534-, L3535-, Q3536-, N3537-, G3538-, M3539-, N3540-, G3541-, R3542-, L3545-, G3546-, S3547-, A3548-, L3549-, L3550-, E3551-, D3552-, E3553-, F3554-, T3555-, P3556-, F3557-, D3558-, V3559-, V3560-, Q3562K, G3565E, V3566K, T3567N, F3568N, S3570-, A3571-, V3572-, K3573-, R3574-, T3575-, I3576-, K3577-, G3578-, T3579-, H3580-, H3581-, W3582-, L3583-, L3584-, L3585-, T3586-, I3587G, L3588Y, S3590P, L3592F, V3595-, Q3596-, S3597-, T3598-, Q3599-, W3600-, S3601-, L3602-, F3603-, F3604-; ORF1b: K151-, D152-, W153-, Y154-, D155-, F156-, V157-, E158R, N159T, P160G, D161M, R164N, N168K, G170-, E171-, R172-, V173-, R174-, Q175-, A176-, L177-, L178-, K179-, T180-, V181-, Q182-, F183-, D185*, A186K, M187Q, R188Y, A190-, G191-, I192-, V193-, G194S, L196V, L198-, D199-, N200-, Q201-, D202-, L203-, N204-, G205-, N206-, W207-, Y208-, D209-, F210-, D212E, I214-, Q215-, T216-, T217-, P218-, G219-, S220-, G221-, V222-, P223-, V224-, V225-, D226-, S227-, Y228-, Y229-, S230-, M233*, I235G, T237*, T239-, R240-, A241-, L242-, T243-, A244-, E245Q, V248M, D249L, D251S, K254L, P255S, Y256G, K258-, W259-, D260-, L261-, L262-, K263-, Y264-, D265-, F266-, T267-, E268-, E269-, R270-, K272-, L273-, F274-, D275-, R276-, Y277-, F278-, K279-, Y280-, W281-, D282-, Q283-, Y285V, H286I, P287L, C289T, N291W, C292M, L293T, D295A, R296F, H300-, C301-, A302-, N303-, F304-, N305-, V306-, L307-, F308-, S309-, T310-, V311-, F312-, P313-, L314-, T315-, S316M, G318Y, P319S, R322-, K323-, I324-, F325-, V326-, D327-, G328-, V329-, P330-, F331-, V332-, V333-, S334-, T335-, G336-, Y337-, H338-, R340S, L342S, G343*, V345-, H346-, N347-, Q348-, D349-, V350-, N351-, H353Y, S354I, S355I, S358-, F359-, K360-, E361-, L362-, L363-, V364-, Y365-, A366-, A367-, D368-, P369-, A370-, M371-, H372-, A373-, A374-, S375-, G376L, N377T, D381-, K382-, R383-, T384-, T385-, C386-, F387-, S388-, V389-, A390-, A391-, L392-, T393-, N394-, N395-, V396R, V401-, K402-, P403-, G404-, N405-, F406-, N407-, K408-, D409-, F410-, Y411-, D412-, F413-, A414-, V415-, S416-, G418S, F419L, F420R, G423-, S424-, S425-, E427L, K429-, H430-, F431-, F432-, F433-, A434-, Q435-, D436-, G437-, A439S, S442-, D443-, Y444-, D445-, Y446-, Y447-, R448-, Y449-, N450-, L451M, P452T, M454I, C455V, D456I, R458Y, F462I, V463S, V464T, E465L, V466I, D468-, K469-, Y470-, F471-, D472-, C473-, Y474-, D475-, G476-, G477-, C478-, I479-, N480-, A481-, N482T, Q483M, I485A, N487L, N488M, D490T, A493N, F495-, P496-, F497-, N498-, K499-, W500-, G501-, K502-, A503V, Y506-, Y507-, D508-, S509-, M510-, S511-, Y512-, E513-, D516-, A517-, L518-, F519-, A520-, Y521-, T522-, K523-, R524-, N525-, V526-, I527-, P528-, T529-, I530-, T531-, Q532-, M533-, Y537*, A538I, I539L, A541M, K542P, N543L, R544V, A545Q, T547S, A549V, G550L, V551*, S552P, C554D, T556F, M557I, T558K, R560-, Q561-, F562-, H563-, Q564-, K565-, L566-, L567-, K568-, S569-, I570-, A571-, A572-, T573-, R574-, G575-, A576-, T577M, I580G, G581T, S583-, K584-, F585-, Y586-, G587-, G588-, W589-, H590-, N591-, L593*, V596L, Y597T, S598L, D599W, E601-, N602-, P603-, H604-, L605-, M606-, G607-, W608-, D609-, Y610-, P611-, K612-, C613-, D614-, R615-, A616-, M617G, P618I, N619I, M620L, L621N, R622V, M624E, A625P, S626C, L629V, R631-, K632-, H633-, T634-, T635-, C636-, C637-, S638-, L639-, S640-, H641-, R642-, F643-, Y644-, R645-, L646-, A647-, N648-, E649-, A651H, Q652T, L654S, S655I, E656D, M657*, V658L, C660S, G661V, G662L, S663K, L664Y, Y665*, G669Q, G670L, T671L, S672M, S673L, G674I, D675V, A676F, T677L, A679-, Y680-, A681-, N682-, S683-, V684-, F685-, N686-, I687-, C688-, Q689-, A690-, V691-, T692-, A693-, N694F, N696F, A697Y, S700-, T701-, D702-, G703-, N704-, K705-, I706-, A707-, D708-, K709-, Y710M, R712T, N713K, Q715V, H716S, R717I, L718E, Y719I, C721M, Y723-, R724-, N725-, R726-, D727-, V728-, D729-, T730-, D731-, F732-, V733-, N734-, E735-, F736-, Y737T, A738Q, Y739T, R741*, K742M, H743S, S745L, M746T, I748L, S750-, D751-, D752-, A753-, V754-, V755-, C756-, F757-, N758-, S759-, T760-, Y761-, A762-, S763-, Q764-, G765-, L766C, A768F, S769I, N772-, F773-, K774-, S775-, V776-, L777-, Y778-, Y779-, Q780-, N781-, N782-, V783-, F784-, M785-, S786-, E787-, A788-, K789-, C790-, W791-, E793L, T794K, T797-, K798-, G799-, P800-, H801-, E802-, F803-, C804-, S805-, Q806-, H807-, T808-, V811N, K812I, G814-, D815-, D816-, Y817-, V818C, Y819*, P821*, Y822G, D824-, P825-, S826-, R827-, I828-, L829-, G830-, A831-, G832-, C833-, F834-, V835-, D836-, D837-, I838-, V839-, K840-, T841-, D842A, G843V, T844L, L845*, E848M, R849L, F850T, V851H, S852L, A854N, D856-, A857-, Y858-, P859-, L860-, T861-, K862-, H863-, P864-, N865-, Q866-, E867-, Y868-, A869-, D870-, V871-, F872-, H873-, L876-, Q877-, Y878-, I879-, R880-, K881-, L882-, H883-, D884-, E885-, L886-, T887-, G888-, H889-, M890-, L891-, D892-, Y894M, V896*, M897Q, L898D, D901L, N902S, T903F, S904M, Y906-, W907-, E908-, P909-, E910-, F911-, Y912-, E913-, A914-, M915-, Y916-, T917-, P918L, H919C, L922F, Q923F, V925-, G926-, A927-, C928-, V929-, L930-, C931-, N932-, S933-, Q934-, T935-, S936-, L937-, R938-, C939-, G940-, A941-, C942-, R944H, P946V, F947N, L948A, C949V, C950T, K951T, C952M, C953S, D955Q, V957H, S959N, T960*, H962C, K963L, V965M, S967Q, N969-, P970-, Y971-, V972-, C973-, N974-, A975-, P976-, G977-, C978-, D979-, V980-, T981-, D982V, V983M, T984S, L986M, Y987*, G989-, G990-, M991-, S992-, Y993-, Y994-, C995-, K996-, S997-, H998-, K999-, P1000-, P1001-, S1003N, F1004H, C1007-, A1008-, N1009-, G1010-, Q1011-, G1014V, Y1016-, K1017-, N1018-, T1019-, C1020-, V1021-, G1022-, S1023-, D1024-, N1025-, V1026-, T1027-, D1028-, F1029-, N1030V, A1033I, C1035F, D1036*, W1037L, N1039-, A1040-, G1041-, D1042-, Y1043-, I1044-, L1045-, A1046-, N1047-, T1048-, C1049-, T1050-, E1051-, R1052-, L1053-, K1054-, L1055-, F1056-, A1057-, A1058-, E1059P, T1060V, A1063*, E1065-, E1066-, T1067-, F1068-, K1069-, L1070-, S1071-, Y1072-, G1073-, I1074-, A1075-, T1076-, V1077-, R1078-, E1079-, D1083-, R1084-, E1085-, L1086-, H1087-, L1088-, S1089-, W1090-, E1091-, V1092-, G1093-, K1094-, P1095-, R1096-, P1097-, P1098-, L1099-, N1100-, R1101-, N1102W, Y1103*, V1104T, F1105*, G1107T, Y1108N, V1110R, T1111V, K1112H, N1113L, S1114*, V1116-, Q1117-, I1118-, G1119-, E1120-, Y1121-, T1122-, F1123-, E1124-, K1125-, G1126-, D1127-, Y1128-, G1129-, D1130-, A1131-, V1132-, V1133-, Y1134-, G1136-, T1137-, T1138-, T1139-, Y1140-, K1141-, L1142-, N1143-, V1144-, G1145-, D1146-, F1148N, V1149N, S1152-, H1153-, T1154-, V1155-, M1156-, P1157-, L1158-, S1159-, A1160-, P1161-, T1162-, L1163-, V1164-, P1165-, Q1166-, E1167-, H1168-, V1170T, R1171S, I1172A, G1174W, Y1176I, T1178-, L1179-, N1180-, I1181-, S1182-, D1183-, E1184-, F1185-, S1186-, S1187-, V1189K, A1190G, N1191W, Q1193A, G1196-, M1197-, Q1198-, K1199-, Y1200-, S1201-, T1202-, L1203-, Q1204F, G1205Y, P1206T, G1210S, K1211L, S1212L, H1213P, A1215-, I1216-, G1217-, L1218-, A1219-, L1220-, Y1221-, Y1222-, P1223-, S1224-, A1225-, R1226-, I1227-, V1228-, Y1229-, T1230-, A1231-, A1235S, A1236V, V1237Y, D1238S, A1239L, C1241G, E1242I, A1244-, L1245-, K1246-, Y1247-, L1248-, P1249-, I1250-, D1251-, K1252-, C1253-, S1254-, R1255-, I1256-, P1258F, R1260S, A1261C, E1264-, C1265-, F1266-, D1267-, K1268-, F1269-, K1270-, V1271-, N1272-, S1273F, L1275*, E1276I, V1279C, F1280K, T1282-, V1283-, N1284-, A1285-, L1286-, P1287-, E1288-, T1289-, T1290-, A1291-, D1292-, V1294A, V1295*, F1296D, I1299-, S1300-, M1301-, A1302-, T1303-, N1304-, Y1305-, D1306-, L1307-, S1308-, V1309-, V1310-, N1311-, A1312-, R1313-, L1314-, R1315-, A1316-, K1317C, H1318C, Y1319Q, V1320C, Y1321Q, G1323T, D1324C, P1325*, Q1327L, L1328C, P1329V, A1330H, P1331W, T1333P, L1334C, L1335S, T1336I, K1337T, G1338C, L1340*, E1341T, P1342Y, Y1344N, F1345Y, N1346R, V1348-, C1349-, R1350-, L1351-, M1352-, K1353-, T1354-, I1355-, G1356-, P1357-, D1358-, M1359-, F1360-, L1361-, G1362-, T1363-, C1364-, R1365-, P1368-, A1369-, E1370-, I1371-, V1372-, D1373-, T1374-, V1375-, S1376-, A1377-, L1378-, V1379-, Y1380-, D1381-, N1382-, K1383-, L1384-, K1385-, A1386-, H1387-, K1388-, D1389-, K1390-, S1391-, A1392-, Q1393-, C1394-, F1395-, K1396-, M1397-, F1398-, Y1399-, K1400-, G1401-, V1402-, I1403-, T1404-, H1405-, D1406-, S1408*, S1409Q, I1411T, Q1415Y, I1416T, G1417*, V1418P, V1419C, R1420L, F1422-, L1423-, T1424-, R1425-, N1426-, P1427-, A1428-, W1429-, R1430-, K1431-, A1432-, V1433-, F1434-, I1435-, S1436-, P1437-, Y1438-, N1439K, Q1441-, N1442-, A1443-, V1444-, A1445-, S1446-, K1447-, I1448-, L1449-, G1450-, L1451-, P1452-, T1453-, Q1454-, V1456T, D1457N, S1459H, Q1460I, G1461H, E1463-, Y1464-, D1465-, Y1466-, V1467-, I1468-, F1469-, T1470-, Q1471-, T1472-, T1473-, E1474-, T1475-, A1476-, H1477-, S1478-, C1479-, N1480-, V1481-, R1483H, F1484*, V1486S, A1487S, I1488L, T1489L, R1490*, A1491C, V1493Q, G1494I, I1495*, L1496C, I1498-, M1499-, S1500-, D1501-, R1502-, D1503-, L1504-, Y1505-, D1506-, K1507-, L1508-, Q1509-, F1510-, T1511-, S1512-, L1513V, E1514A, P1516Y, R1517K, R1518S, N1519*, V1520N, A1521S, L1523*, Q1524E, A1525C, E1526G, V1528F, L1531N, F1532H, K1533W, D1534V, C1535T, K1537-, V1538-, I1539-, T1540-, G1541-, L1542-, H1543-, P1544-, T1545-, Q1546-, A1547-, P1548-, T1549-, H1550-, L1551-, S1552-, V1553-, D1554Y, K1556G, F1557T, K1558Y, E1560P, G1561Q, L1562C, C1563*, V1564H, D1565*, P1567K, G1568T, I1569H, P1570L, K1571Y, M1573G, T1574F, Y1575*, R1576N, R1577E, I1579S, M1581-, M1582-, G1583-, F1584-, K1585-, M1586-, N1587-, Y1588-, Q1589-, V1590-, N1591-, G1592-, Y1593-, P1594-, N1595-, M1596-, F1597-, I1598-, T1599-, R1600-, E1601*, E1602W, A1603L, I1604P, R1605*, A1609-, W1610-, I1611-, G1612-, F1613-, D1614-, V1615-, E1616-, G1617-, C1618-, H1619-, A1620-, T1621-, R1622-, E1623-, A1624-, V1625-, N1628-, L1629-, P1630-, L1631-, Q1632-, L1633-, G1634-, F1635-, S1636-, T1637-, G1638-, V1639-, N1640-, L1641-, V1642-, V1644-, P1645-, T1646-, G1647-, Y1648-, V1649-, D1650-, T1651-, P1652-, N1653-, N1654-, D1656*, F1657*, S1658Y, V1660R, A1662I, K1663*, P1664T, P1666T, G1667Y, D1668V, F1670R, K1671T, H1672S, I1674E, P1675C, L1676S, M1677A, G1680-, L1681-, P1682-, W1683-, N1684-, V1685-, V1686-, R1687-, I1688-, K1689-, I1690-, V1691-, Q1692-, M1693-, L1694-, S1695-, L1698*, N1700S, S1702-, D1703-, R1704-, V1705-, V1706-, F1707-, V1708-, L1709-, W1710-, A1711-, H1712-, F1714T, E1715W, T1717*, S1718V, M1719D, K1720I, F1722E, K1724-, I1725-, G1726-, P1727-, E1728-, R1729-, T1730-, C1731F, L1733E, C1734N, D1735R, R1736T, R1737*, T1739H, C1740L, F1741L, T1743L, D1746-, T1747-, Y1748-, A1749-, C1750-, W1751-, H1752-, H1753-, S1754-, I1755-, G1756-, F1757-, D1758-, Y1759-, V1760-, Y1761-, N1762-, P1763-, I1766-, D1767-, V1768-, Q1769-, Q1770-, W1771-, T1774*, G1775S, N1776V, Q1778S, N1780P, H1781W, D1782*, L1783C, Y1784T, Q1786S, V1787*, H1788L, G1789*, N1790C, A1791N, A1794S, D1797-, A1798-, I1799-, M1800-, T1801-, R1802-, C1803-, L1804-, A1805-, V1806-, H1807-, E1808-, C1809-, F1810-, V1811-, K1812P, W1816Y, T1817*, E1819S, P1821-, I1822-, I1823-, G1824-, D1825-, E1826-, L1827-, K1828-, I1829-, A1831H, A1832G, R1834-, K1835-, V1836-, Q1837-, H1838-, M1839-, V1840-, V1841-, K1842-, A1843-, A1844-, L1845-, L1846-, A1847-, D1848-, K1849-, F1850-, P1851-, V1852*, L1853S, H1854C, D1855I, G1857-, N1858-, P1859-, K1860-, A1861-, I1862-, K1863-, C1864-, V1865-, P1866-, Q1867-, A1868-, D1869-, V1870-, E1871-, W1872-, K1873-, F1874-, Y1875-, D1876-, A1877S, Q1878S, P1879*, D1882L, K1883*, A1884N, Y1885R, K1886R, E1888-, E1889I, Y1892-, S1893-, Y1894-, A1895-, T1896-, H1897-, S1898-, D1899-, K1900-, F1901-, T1902-, D1903-, G1904L, V1905C, C1906H, L1907T, W1909*, N1910Q, C1911I, N1912H, V1913R, D1914W, R1915C, Y1916M, A1918I, N1919L, S1920E, I1921L, V1922Q, F1925-, D1926-, T1927-, R1928-, V1929-, L1930-, S1931-, N1932-, L1933-, N1934-, L1935-, P1936-, G1937-, C1938-, D1939-, G1940-, G1941-, S1942-, Y1944F, N1946C, H1948C, A1949I, F1950P, P1953S, A1954F, F1955*, D1956*, S1958T, A1959I, V1961L, N1962L, K1964*, L1966-, P1967-, F1968-, F1969-, Y1970-, Y1971-, S1972-, D1973-, S1974-, P1975-, C1976-, E1977-, S1978-, H1979-, G1980-, K1981S, Q1982M, V1983*, D1986C, I1987Y, D1988V, V1990N, P1991T, K1993Q, S1994F, A1995R, T1996W, I1998-, T1999-, R2000-, C2001-, N2002-, L2003-, G2004-, G2005-, A2006-, V2007-, C2008-, R2009-, H2010-, H2011-, A2012-, N2013-, E2014-, Y2015-, R2016C, Y2018D, D2020-, A2021-, Y2022-, N2023-, M2024-, M2025-, I2026-, S2027-, A2028-, G2029-, F2030-, S2031-, L2032S, Y2035G, K2036L, F2038-, D2039-, T2040-, Y2041-, N2042-, L2043-, W2044-, N2045-, F2047I, T2048*, R2049Y, Q2051*, S2052P, N2055K, V2056C, A2057G, N2059*, V2060C, V2061C, N2062K, K2063*, H2065S, D2067-, G2068-, Q2069-, Q2070-, G2071-, E2072-, V2073-, P2074-, V2075-, S2076-, I2077-, I2078-, N2079-, N2080-, T2081-, V2082-, T2084-, K2085-, V2086-, D2087-, G2088-, V2089-, D2090-, V2091-, E2092-, L2093-, F2094-, E2095-, N2096-, K2097-, T2098-, T2099-, L2100-, P2101-, V2102-, N2103-, F2106Q, E2107H, L2108*, W2109T, A2110S, K2111T, N2113-, I2114-, K2115-, P2116-, V2117-, P2118-, E2119-, V2120-, K2121-, I2122-, L2123-, N2124-, N2125-, L2126-, V2128C, I2130-, A2131-, A2132-, N2133-, T2134-, V2135-, I2136L, W2137G, D2138L, Y2139Q, D2142-, A2143-, P2144-, A2145-, H2146-, I2147-, S2148-, T2149-, I2150-, G2151-, V2152-, M2155S, D2157Y, A2159*, K2160N, K2161D, P2162L, T2163C, E2164T, I2166H, A2168-, P2169-, L2170-, T2171-, V2172-, F2173L" }, "mutations": { "ORF1a": [ "G519-", "A520-", "W521-", "N522-", "I523-", "G524-", "E525-", "Q526-", "K527-", "S528-", "I529-", "L530-", "S531V", "A535D", "F536Q", "A537F", "E539P", "A541-", "R542-", "V543-", "V544-", "R545-", "S546-", "I547-", "F548-", "S549-", "R550-", "T551-", "L552-", "E553-", "T554-", "A555-", "Q556-", "N557-", "S558-", "V559-", "R560-", "V561-", "Q563L", "A565-", "A566L", "I567L", "T568K", "D571H", "G572S", "S574H", "Q575*", "Y576D", 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