Ontology about the development and life stages of the C. elegans
Editors: Wen J. Chen & Daniela Raciti, Raymond Lee, Chris Grove, WormBase, Caltech. Jane Lomax, Wellcome Trust Sanger Institute.
definition
The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
PERSON:Daniel Schober
term replaced by
Use on obsolete terms, relating the term to another term that can be used as a substitute
Person:Alan Ruttenberg
Add as annotation triples in the granting ontology
If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL
If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.
is a defining property chain axiom where second argument is reflexive
An alternative label for a class or property which has a more general meaning than the preferred name/primary label.
has broad synonym
disease characteristic (MONDO:0021125) has cross-reference (http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C41009"^^xsd:string
An annotation property that links an ontology entity or a statement to a prefixed identifier or URI.
An alternative label for a class or property which has the exact same meaning than the preferred name/primary label.
has exact synonym
An alternative label for a class or property which has a more specific meaning than the preferred name/primary label.
has narrow synonym
An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct.
has related synonym
is part of
my brain is part of my body (continuant parthood, two material entities)
my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
this day is part of this year (occurrent parthood)
a core relation that holds between a part and its whole
Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
part_of
part of
has part
my body has part my brain (continuant parthood, two material entities)
my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
this year has part this day (occurrent parthood)
a core relation that holds between a whole and its part
Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
has_part
preceded by
x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
is preceded by
preceded_by
precedes
x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
inheres in
this fragility is a characteristic of this vase
this red color is a characteristic of this apple
a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
inheres_in
Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
characteristic of
bearer of
this apple is bearer of this red color
this vase is bearer of this fragility
Inverse of characteristic_of
A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
bearer_of
is bearer of
has characteristic
participates in
this blood clot participates in this blood coagulation
this input material (or this output material) participates in this process
this investigator participates in this investigation
a relation between a continuant and a process, in which the continuant is somehow involved in the process
participates_in
has participant
this blood coagulation has participant this blood clot
this investigation has participant this investigator
this process has participant this input material (or this output material)
a relation between a process and a continuant, in which the continuant is somehow involved in the process
Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
has_participant
this catalysis function is a function of this enzyme
a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.
function_of
is function of
This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020.
function of
this red color is a quality of this apple
a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
A quality inheres in its bearer at all times for which the quality exists.
is quality of
quality_of
quality of
this investigator role is a role of this person
a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
is role of
role_of
role of
this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
has_function
has function
this apple has quality this red color
a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
has_quality
has quality
this person has role this investigator role (more colloquially: this person has this role of investigator)
a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
has_role
has role
a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence
has disposition
disposition of
A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
By convention GO molecular functions are classified by their effector function. Internal regulatory functions are treated as components. For example, NMDA glutmate receptor activity is a cation channel activity with positive regulatory component 'glutamate binding' and negative regulatory components including 'zinc binding' and 'magnesium binding'.
has negative regulatory component activity
A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
has positive regulatory component activity
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)
ends after
X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
immediately preceded by
X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)
immediately precedes
x overlaps y if and only if there exists some z such that x has part z and z part of y
http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
overlaps
w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
has component
x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
This is the transitive form of the develops from relation
develops from
develops into
p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.
Regulation precludes parthood; the regulatory process may not be within the regulated process.
regulates
p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.
negatively regulates (process to process)
negatively regulates
p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.
positively regulates (process to process)
positively regulates
mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
osteoclast SubClassOf 'capable of' some 'bone resorption'
A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
capable of
c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
capable of part of
Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.
temporally related to
p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
has input
Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]
x has developmental contribution from y iff x has some part z such that z develops from y
has developmental contribution from
inverse of has developmental contribution from
developmentally contributes to
Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
In general you should not use this relation to make assertions - use one of the more specific relations below this one
This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from
developmentally preceded by
A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision.
c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.
A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway.
c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
developmentally succeeded by
p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q.
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q.
q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
Because part_of is transitive, inheres in is a sub-relation of characteristic of part of
characteristic of part of
A mereological relationship or a topological relationship
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
mereotopologically related to
A relationship that holds between entities participating in some developmental process (GO:0032502)
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development
developmentally related to
a particular instances of akt-2 enables some instance of protein kinase activity
c enables p iff c is capable of p and c acts to execute p.
This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
enables
A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
This is a grouping relation that collects relations used for the purpose of connecting structure and function
functionally related to
this relation holds between c and p when c is part of some c', and c' is capable of p.
part of structure that is capable of
c involved_in p if and only if c enables some process p', and p' is part of p
involved in
enabled by
regulated by
negatively regulated by
positively regulated by
input of
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
has developmental potential involving
x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
has potential to developmentally contribute to
x has the potential to develop into y iff x develops into y or if x is capable of developing into y
This relation has a stronger meaning than merely indicating that X may develop into Y, in that the capability of developing into Y is always present, even if X does not always actually develop into Y. In particular, this means that if Y is restricted to a given taxon T, X is necessarily likewise restricted.
has potential to develop into
x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
has potential to directly develop into
causally downstream of
immediately causally downstream of
p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q.
indirectly positively regulates
p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q.
indirectly negatively regulates
relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative? The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yield a cross-product of different relation types.
Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
causally related to
p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q.
causally upstream of
p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q.
immediately causally upstream of
p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q.
We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
inverse of causally upstream of or within
c involved in regulation of p if c is involved in some p' and p' regulates some p
c involved in regulation of p if c is involved in some p' and p' positively regulates some p
c involved in regulation of p if c is involved in some p' and p' negatively regulates some p
c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p
OWL does not allow defining object properties via a Union
involved in or involved in regulation of
A relationship that holds between two entities in which the processes executed by the two entities are causally connected.
This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact.
Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules.
An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.
An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y.
The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.
The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.
directly negatively regulates activity of
The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.
directly positively regulates activity of
This property or its subproperties is not to be used directly. These properties exist as helper properties that are used to support OWL reasoning.
helper property (not for use in curation)
A relationship between a material entity and a process where the material entity has some causal role that influences the process
p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q.
The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
molecular interaction relation helper property
The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).
p directly regulates q iff p is immediately causally upstream of q and p regulates q.
gland SubClassOf 'has part structure that is capable of' some 'secretion by cell'
s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
causal relation between material entity and a process
Holds between c and p if and only if c is capable of some activity a, and a regulates p.
Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
renin -> arteriolar smooth muscle contraction
Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q.
directly positively regulates (process to process)
p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q.
directly negatively regulates (process to process)
Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.
acts upstream of or within, positive effect
acts upstream of or within, negative effect
c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive
c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative
causally upstream of or within, negative effect
causally upstream of or within, positive effect
The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.
p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.
indirectly causally upstream of
p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.
indirectly regulates
A diagnostic testing device utilizes a specimen.
X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.
A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input.
See github ticket https://github.com/oborel/obo-relations/issues/497
device utilizes material
A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C.
A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C.
A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C.
This property only applies to anatomical entities.
An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
continuant
An entity that has temporal parts and that happens, unfolds or develops through time.
occurrent
b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
disposition
A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
realizable entity
quality
b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
role
function
An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
Elucidation: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
material entity
A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
This is the same as GO molecular function
Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex.
gene product or complex activity
A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.
biological process
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
curation status specification
The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value.
Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)
PERSON:Bill Bug
A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
The nematode life-cycle stage that occurs entirely outside of a host organism.
All C. elegans development stages, including embryo, larva and adult stage.
The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.
The C. elegans life stage spanning 0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage until cleavage is over.
The C. elegans life stage spanning 0-100min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 28 cells. From first cleavage until the start of gastrulation.
Also called zygote. -50min till 0min of first cleavage at 20 Centigrade. Contains 1 cell.
The C. elegans life stage spanning 0-20min after first cleavage at 20 Centigrade. Contains 2 cells.
The C. elegans life stage spanning 20-40min after first cleavage at 20 Centigrade. Contains 4 cells.
The C. elegans life stage spanning 100-105 min after first cleaveage at 20 Centigrade. Contains 28 cells.
The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation.
The C. elegans life stage spanning 120-135 min after first cleavage at 20 Centigrade. Contains 51 cells.
The C. elegans life stage spanning 145-150 min after first cleavage at 20 Centigrade. Contains 88 cells.
The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.
The C. elegans life stage spanning 210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes.
The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.
The C. elegans life stage spanning 350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage.
The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo.
The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.
The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo.
The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage.
The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.
A developemental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until death.
A developmental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until adulthood.
The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.
The stage during L1-L2 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from L1 larva to L2 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.
The stage during L2-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from L2 larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The stage during L2d-dauer molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from L2d larva to dauer larva. It includes the synthesis of new cuticle, cease of pharyngeal pumping during a lethargus stage, and the shed off of old cuticle.
A third stage larva specialized for dispersal and long term survival.
The stage during postdauer-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from post dauer stage to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.
The stage during L3-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from L3 larva to L4 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.
The stage during L4-adult molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage when an animal shifts from L4 larva to adult. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The stage that begins when a C.elegans individual is fully-developed and has reached maturity.
The stage during L1-L2 molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage when an animal shifts from L1 larva to L2d larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The stage during L1-L2d molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage during L1-L2d molt, after the brief lethargus period, when an animal sheds off old cuticle.
A special second stage larva with altered physiology and developmental potential that leads to formation of dauer larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.
The stage during L2-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage during L2d-dauer molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage during L3-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage during L4-adult molt, after the brief lethargus period, when an animal shed off old cuticle.
The stage during postdauer-L4 molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage right after an animal recovered from dauer but has not started transformation to L4 larva yet.
"By ~10-12 hours after stimulation to recovery at 20 degrees Celsius, or ~7-8 hours at 25 degrees Celsius, they reach the PDL3 (post-dauer L3 stage), where cell division and development have resumed. Cell fates, including cell divisions and expression of cell fate markers, are equivalent between L3 and PDL3 stages (Liu and Ambros, 1991; Euling and Ambros, 1996; Braendle and Félix, 2008; Karp and Greenwald, 2013). However, no molt occurs between dauer and PDL3. Thus, dauer alae are still visible on the cuticle, although more difficult to see because they become stretched as the larva loses radial constriction and begins to grow (Cassada and Russell, 1975; Riddle et al.,1997)."
The stage when an animal shifts from L2d larva to L3 larva. It includes the synthesis of new cuticle, cease of phrayngeal pumping during a lethargus stage, and the shed off of old cuticle.
The stage during L2d-L3 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old.
The stage during L2d-L3 molt, after the brief lethargus period, when an animal sheds off old cuticle.
The stage after an male animal is fully-developed and reaches maturity.
The stage after an hermaphrodite animal is fully-developed and reaches maturity.
Very young adult hermaphrodites that do not have eggs in the uterus yet. At 20 Centigrade: 0 - 13 hours after L4-adult molt. 3 days after first cleaveage.
pre-reproductive stage adult hermaphrodite
pre-reproductive stage adult hermaphrodite Ce
The nematode life-cycle stage that occurs entirely or partially within a host or vector organism.
Adult hermaphrodites continuously laying fertilized eggs. Hermaphrodite in egg laying stages--usually up to 4/5 days after L4-adult molt at Centigrade. From the first fertilized egg is laid, till all sperms are used. At 20 Centigrade: 13 hours after L4-adult molt until about 5.4 days after the L4-adult molt. 3-8.4 days after first cleavage.
reproductive stage adult hermaphrodite Ce
When egg-laying is still going on but intermittent and during which a significant number of oocytes are laid. Included in reproductive stage adult hermaphrodite.
oocyte-laying stage adult hermaphrodite Ce
Adult hermaphrodites that contain no more sperm, thus stop egg-laying, but still alive. At 20 Centigrade: 5.4 days after L4-adult molt until the death. 8.4 - 13.2 (average wild type life span) days after first cleavage.
post-reproductive stage adult hermaphrodite
post-reproductive stage adult hermaphrodite Ce
At 20 Centigrade: 0-24 hours after L4-adult molt.
newly molted young adult hermaphrodite Ce
At 20 Centigrade: 24-48 hours after L4-adult molt. 4-5 days after first cleavage.
At 20 Centigrade: 48-72 hours after L4-adult molt. 5-6 days after first cleavage.
At 20 Centigrade: 72-96 hours after L4-adult molt. 6-7 days after first cleavage.
At 20 Centigrade: 96-120 hours after L4-adult molt. 7-8 days after first cleavage.
At 20 Centigrade: 5-6 days after L4-adult molt. 8-9 days after first cleavage.
At 20 Centigrade: 4-7 days after L4-adult molt. 7-10 days after first cleavage.
At 20 Centigrade: 7-10 days after L4-adult molt. 10-13 days after first cleavage.
7-10 days post-L4 adult hermaphrodite Ce
The C. elegans life stage spanning ~50 min after first cleavage at 20 Centigrade. Contains 8 cells.
The C. elegans life stage spanning ~55 min after first cleavage at 20 Centigrade. Contains 12 cells.
The fourth stage larva male. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.
At 20 Centigrade: 11-15 days after L4-adult molt. 14-18 days after first cleavage.
11-15 days post-L4 adult hermaphrodite Ce
Any Strongyloides developmental stage, including free-living and parasitic stages.
A Brugia microfilaria life stage in which larvae are surrounded by a membrane thought to be derived from the vitelline membrane, hence "sheathed".
The second stage larva. Derived from flight muscles of vector host; some development in vitro, with L1 to L2 moulting, has been demonstrated but rarely; these are often staged by hours or days post blood meal.
The fourth stage larva. Should be conditioned by days post infection; as moulting is not synchronous, some samples are defined as L3/L4, indicating a mix of individuals as late L3, moulting, and early L4.
The life-stage that begins when a B. malayi individual is fully-developed and has reached maturity. Adult B. malayi (or at least adult females) can live for 10 years in a human host, and can outlive their rodent laboratory hosts; it is usual to state the chronological age of the nematodes in days or months post-infection, and occasionally post-patency (the production of first microfilariae).
E-cell has divided into Ea and Ep. Contains 14 cells.
Levin M, Hashimshony T, Wagner F, Yanai I. Developmental milestones punctuate gene expression in the Caenorhabditis embryo. Dev Cell. 2012 May 15;22(5):1101-8. Epub 2012 May 3. PubMed PMID: 22560298. Supplementary table 1.
Fourth cleavage of the AB lineage. Contains 24 cells.
Fifth cleavage of the AB lineage. Contains 44 cells.
Sixth cleavage of the AB lineage. Contains 68 cells.
Seventh cleavage of the AB lineage. Contains 86 cells.
P4 and M cells have finished migrating. Contains 190 cells.
The C. elegans life stage spanning 155-165 min after first cleavage at 20 Centigrade. Contains 96 cells.
Any Brugia developmental stage, including embryo, larva and adult stage.
The whole period of embryogenesis in a roundworm of the genus Brugia, from the formation of an egg until hatching.
A developemental life stage in a roundworm of the genus Brugia that occurs from egg hatching until death.
Proliferates from 1 to 100 cells. As the Brugia female reproductive tract is long (>10 cm), it is possible to dissect it and select early embryos just by isolating early parts of the post-spermatheca uterus.
Proliferates from 100 cells to Lima bean stage.
A developmental life stage of a roundworm of the genus Brugia that occurs from egg hatching until adulthood.
Also known as infective L3, or iL3; i.e. isolated from the vector salivary glands; these samples may-should be conditioned by age, which is usually counted in days from the blood meal.
Derived from the host after reintroduction by vector feeding or manual inoculation; these piL3 samples are often-should be conditioned by age (hours or days post-infection).
The animals have a significant "prepatent" period in the host, where they have moulted to adults but not yet started producing eggs or sperm; this stage is usually-should be conditioned by days post infection, with day 26 to approximately day 60 being the "young adult" in most systems - but note that the speed of development is different in different host genotypes.
Any developmental stage in a nematode, including embryo, larva and adult stage.
The whole period of embryogenesis in a nematode, from the formation of an egg until hatching.
A developemental life stage in a nematode that occurs from egg hatching until death.
The nematode life-stage that begins when the organism is fully-developed and has reached maturity.
The stage that begins after hatching and ends when the nematode becomes adult.
A microfilaria life stage in which larvae are surrounded by a membrane thought to be derived from the vitelline membrane, hence "sheathed".
At 20 Centigrade: 16-18 days after L4-adult molt. 18-21 days after first cleavage.
16-18 days post-L4 adult hermaphrodite Ce
The time period encompassing the 1st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 2nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 3rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 4th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 5th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 6th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 7th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 8th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 9th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 10th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 11st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 12nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 13rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 14th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 15th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 16th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 17th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 18th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 19th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 20th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 21st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 22nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 23rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 24th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 25th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 26th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 27th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 28th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 29th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 30th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 31st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 32nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 33rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 34th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 35th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 36th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 37th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 38th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 39th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 40th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 41st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 42nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 43rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 44th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 45th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 46th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 47th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 48th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 49th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 50th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 51st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 52nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 53rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 54th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 55th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 56th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 57th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 58th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 59th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 60th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 61st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 62nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 63rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 64th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 65th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 66th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 67th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 68th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 69th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 70th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 71st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 72nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 73rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 74th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 75th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 76th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 77th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 78th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 79th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 80th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 81st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 82nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 83rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 84th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 85th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 86th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 87th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 88th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 89th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 90th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 91st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 92nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 93rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 94th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 95th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 96th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 97th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 98th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 99th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 100th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 101st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 102nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 103rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 104th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 105th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 106th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 107th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 108th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 109th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 110th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 111st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 112nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 113rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 114th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 115th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 116th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 117th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 118th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 119th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 120th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 121st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 122nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 123rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 124th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 125th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 126th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 127th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 128th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 129th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 130th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 131st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 132nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 133rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 134th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 135th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 136th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 137th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 138th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 139th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 140th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 141st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 142nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 143rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 144th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 145th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 146th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 147th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 148th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 149th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 150th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 151st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 152nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 153rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 154th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 155th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 156th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 157th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 158th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 159th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 160th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 161st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 162nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 163rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 164th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 165th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 166th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 167th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 168th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 169th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 170th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 171st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 172nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 173rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 174th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 175th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 176th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 177th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 178th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 179th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 180th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 181st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 182nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 183rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 184th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 185th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 186th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 187th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 188th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 189th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 190th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 191st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 192nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 193rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 194th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 195th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 196th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 197th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 198th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 199th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 200th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 201st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 202nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 203rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 204th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 205th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 206th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 207th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 208th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 209th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 210th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 211st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 212nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 213rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 214th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 215th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 216th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 217th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 218th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 219th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 220th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 221st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 222nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 223rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 224th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 225th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 226th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 227th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 228th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 229th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 230th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 231st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 232nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 233rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 234th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 235th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 236th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 237th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 238th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 239th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 240th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 241st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 242nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 243rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 244th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 245th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 246th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 247th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 248th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 249th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 250th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 251st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 252nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 253rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 254th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 255th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 256th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 257th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 258th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 259th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 260th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 261st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 262nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 263rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 264th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 265th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 266th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 267th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 268th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 269th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 270th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 271st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 272nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 273rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 274th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 275th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 276th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 277th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 278th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 279th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 280th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 281st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 282nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 283rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 284th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 285th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 286th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 287th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 288th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 289th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 290th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 291st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 292nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 293rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 294th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 295th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 296th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 297th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 298th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 299th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 300th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 301st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 302nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 303rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 304th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 305th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 306th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 307th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 308th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 309th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 310th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 311st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 312nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 313rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 314th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 315th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 316th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 317th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 318th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 319th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 320th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 321st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 322nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 323rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 324th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 325th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 326th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 327th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 328th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 329th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 330th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 331st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 332nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 333rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 334th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 335th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 336th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 337th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 338th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 339th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 340th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 341st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 342nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 343rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 344th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 345th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 346th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 347th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 348th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 349th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 350th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 351st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 352nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 353rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 354th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 355th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 356th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 357th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 358th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 359th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 360th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 361st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 362nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 363rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 364th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 365th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 366th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 367th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 368th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 369th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 370th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 371st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 372nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 373rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 374th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 375th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 376th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 377th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 378th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 379th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 380th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 381st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 382nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 383rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 384th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 385th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 386th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 387th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 388th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 389th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 390th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 391st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 392nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 393rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 394th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 395th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 396th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 397th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 398th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 399th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 400th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 401st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 402nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 403rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 404th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 405th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 406th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 407th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 408th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 409th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 410th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 411st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 412nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 413rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 414th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 415th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 416th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 417th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 418th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 419th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 420th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 421st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 422nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 423rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 424th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 425th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 426th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 427th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 428th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 429th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 430th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 431st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 432nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 433rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 434th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 435th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 436th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 437th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 438th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 439th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 440th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 441st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 442nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 443rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 444th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 445th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 446th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 447th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 448th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 449th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 450th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 451st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 452nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 453rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 454th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 455th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 456th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 457th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 458th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 459th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 460th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 461st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 462nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 463rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 464th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 465th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 466th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 467th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 468th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 469th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 470th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 471st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 472nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 473rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 474th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 475th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 476th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 477th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 478th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 479th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 480th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 481st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 482nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 483rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 484th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 485th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 486th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 487th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 488th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 489th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 490th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 491st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 492nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 493rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 494th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 495th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 496th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 497th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 498th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 499th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 500th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 501st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 502nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 503rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 504th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 505th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 506th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 507th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 508th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 509th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 510th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 511st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 512nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 513rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 514th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 515th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 516th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 517th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 518th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 519th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 520th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 521st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 522nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 523rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 524th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 525th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 526th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 527th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 528th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 529th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 530th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 531st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 532nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 533rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 534th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 535th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 536th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 537th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 538th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 539th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 540th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 541st minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 542nd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 543rd minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 544th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 545th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 546th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 547th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 548th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 549th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 550th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
In the mosquito, the microfilariae shed sheaths, penetrate the midgut, and migrate to the thoracic muscles were the microfilariae increase in size, molt, and develop into infective larvae (L1 and L3) over a span of 7-21 days.
An early stage in the life cycle of some parasitic nematodes which develops from the egg and precedes the L1 stage.
Anderson, R.C. (2000) Nematode Parasites of Vertebrates: Their Development and Transmission. Second Edition. CABI Publishing: Wallingford, England, pp. 472-475.
An early stage in the life cycle of Brugia species, which develops from the egg and precedes the L1 stage.
A microfilaria life stage in which larvae are not sheathed by a membrane thought to be derived from the vitelline membrane.
Microfilaria larvae found in nodules and ulcers.
Microfilaria larvae found subcutaneously
A developmental life stage of the nematode Caenorhabditis elegans that occurs in an egg (oocyte), before fertilization by sperm.
At 20 Centigrade: 6-7 days after L4-adult molt. 9-10 days after first cleavage.
At 20 Centigrade: 7-8 days after L4-adult molt. 10-11 days after first cleavage.
At 20 Centigrade: 8-9 days after L4-adult molt. 11-12 days after first cleavage.
At 20 Centigrade: 9-10 days after L4-adult molt. 12-13 days after first cleavage.
At 20 Centigrade: 10-11 days after L4-adult molt. 13-14 days after first cleavage.
At 20 Centigrade: 15-16 days after L4-adult molt. 18-19 days after first cleavage.
At 20 Centigrade: 20-21 days after L4-adult molt. 23-24 days after first cleavage.
The stage of the Strongyloides life-cycle that occurs entirely outside of a host or vector organism.
The stage of the Strongyloides life-cycle that occurs entirely or partially inside a host or vector organism.
Larval stage that is capable of infecting a host organism.
Host organism here refers to the main host organism rather than intermediate hosts.
Strongyloides infective stage L3 larval stage. This stage can develop as a part of a free-living life-cycle, or from a parasitic, parthenogenic female stage.
The Strongyloides life-cycle stage during which a female adult worm produces larval progeny parthenogenetically within the host organism.
The Strongyloides life-cycle stage in which male and female adult worms reproduce sexually and live entirely outside a host organism.
The first sub-stage of the L4 larva. All vulval cells are migrating toward the center of the future vulva. vulA, vulB, and vulE have divided, but vulC and vulF have not. At 20 Centigrade: 34.3 hours after hatching, 0.3 hours from the L3-to-L4 molt.
The second sub-stage of the L4 larva. The inner cells of the vulva have finished migrating and have formed toroids, but have not fused. vulC and vulF have divided and a narrow lumen has formed. At 20 Centigrade: 35.1 hours after hatching, 1.1 hours from the L3-to-L4 molt.
The third sub-stage of the L4 larva. All vulval cells complete migration. vulA, vulC, and vulD undergo cell fusion. The vulval lumen has widened and a prominent kink has formed between vulC and vulD. The uterine lumen has not started to form. At 20 Centigrade: 36.8 hours after hatching, 2.8 hours from the L3-to-L4 molt.
The fourth sub-stage of the L4 larva. vulFs have separated and the apex of the lumen is flat and capped by the anchor cell. The uterine lumen starts to form. At 20 Centigrade: 38.1 hours after hatching, 4.1 hours from the L3-to-L4 molt.
The fifth sub-stage of the L4 larva. utse is visible as a thin layer separating the vulval and uterine lumens. 'Fingers' are formed at the sides of the vulva next to vulB1 and vulB2. The uterine lumen is fully distended. At 20 Centigrade: 39.0 hours after hatching, 5.0 hours from the L3-to-L4 molt.
The sixth sub-stage of the L4 larva. The side of the vulval lumen between vulC and vulD forms a smooth curve. At 20 Centigrade: 40.4 hours after hatching, 6.4 hours from the L3-to-L4 molt.
The seventh sub-stage of the L4 larva. 'Fingers' between vulB2 and vulC are pointed ventrally. At 20 Centigrade: 41.5 hours after hatching, 7.5 hours from the L3-to-L4 molt.
The eighth sub-stage of the L4 larva. vulFs have migrated closer such that the lumen is narrowed in the dorsal section. The approximate cutoff is when the width of the channel is less than the width of the vulD nucleus. At 20 Centigrade: 42.3 hours after hatching, 8.3 hours from the L3-to-L4 molt.
The ninth sub-stage of the L4 larva. The vulval lumen is partially collapsed. At 20 Centigrade: 42.5 hours after hatching, 8.5 hours from the L3-to-L4 molt.
The tenth sub-stage of the L4 larva. The vulval lumen is completely collapsed. At 20 Centigrade: 42.8 hours after hatching, 8.8 hours from the L3-to-L4 molt.
The time period encompassing the 560th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 570th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 640th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 650th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 660th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 720th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 770th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 780th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 820th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 830th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
The time period encompassing the 850th minute post first cleavage at 20 Centigrade with respect to Sulston's lineage tree.
Any developmental stage in Platyhelminthes (flatworms).
The egg stage of the Platyhelminthes life cycle. The stage ends upon hatching.
Free-swimming larval stage. Once the egg is released into environment, the miracidium hatches immediately and starts swimming in search of an intermediate host. In Schistosoma mansoni this is a snail of species Biomphalaria.
A sac-like secondary larval stage. The miracidium transforms into a primary (mother) sporocyst; germ cells within the primary sporocyst begin dividing to produce secondary (daughter) sporocysts, which migrate to the snail hepatopancreas; once at the hepatopancreas, germ cells within the secondary sporocyst begin to divide again, this time producing cercariae.
An infectious life-cycle stage, which can infect by direct skin penetration (e.g. Schistosoma sp.) or ingestion (e.g. Fasciola sp.). Cercariae develop in and emerge from the intermediate invertebrate (snail) host. In Schistosoma sp., the cercarium attaches to the skin of the definitive host and secretes proteolytic enzymes helping it to enter into cutaneous capillary vessel; upon the penetration the cercarium sheds its tail and transforms into a schistosomulum. In Fasciola sp., cercariae encyst on vegetation as dormant metacercariae until ingestion by the definitive host.
A tailless cercarium of Schistosoma sp, which resides in the definitive host. After penetration and spending a few days in the skin, schistosomula migrate to the lungs and enter the systemic circulation and are carried to the mesenteric vein of the host where they mature into adult schistosomes.
The mature, fully developed life stage of Platyhelminthes, usually capable of sexual reproduction.
A developmental stage of a Digenean (fluke).
Digeneans include the Schistosomatidae (blood flukes).
Any developmental stage of a Cestode (tapeworm).
A six-hooked larva, called the hexcanth, enclosed by one or two embryonic envelopes. This stage invades the first (or sole) intermediate host where it develops into a bladder larva, such as a hydatid cyst.
A larval stage of cestodes characterized by internal (and often external) chambers lined by germinal epithelium. The inner germinal layer of hydatid cysts is cellular and the protoscolex develops from those cells.
Note that a hydatid cyst is a type of bladder larva, a larval form in which one or more scoleces develop in a fluid-filled cyst. Other types of bladder larva include cysticercus, coenurus and strobilocercus.
An infective larval stage of cestodes which develops from the hydatid cyst. The stage begins when a clustering of cells emerge from the germinal layer of hydatid cysts. The buds elongate and the cells at their bases seem to diminish in number. Very early on a furrow appears in the elongated buds, delimiting anterior (scolex) and caudal (body) regions. Hooks are the first fully-differentiated structures formed at the apical region of the nascent scolex. A cone can later be seen at the center of the hooks, the body is expanded and a structured neck is evident between the scolex and the body. During protoscolex development this parasitic form remains attached to the germinative layer through a stalk. When fully differentiated, the stalk is cut off and the infective protoscolex is now free in the hydatid fluid. This stage ends when the protoscolex attaches, via the scolex, to the host intestinal tissue and begins to develop into a adult.
The larval stages of a tapeworm, beginning with the metamorphosis of the oncosphere and ending with the first evidence of sexuality in the adult worm. Includes the procercoid and plerocercoid stages of pseudophyllid cestodes, and the cysticercus, cysticercoid, coenurus, and hydatid stages of cyclophyllidean cestodes.
A larval stage of some cestodes, including Hymenolepis sp. The cysticercoid is a type of cyst that is found in free form as well as being tissue-enclosed.
A Digenean (fluke) life stage that occurs in the definitive host. The stage begins when the metacercariae excyst in the intestine of the host, and continues as the NEJs migrate through the liver parenchyma where they increase in size to juvenile flukes and then to mature adults.
A Digenean (fluke) life stage that occurs in the definitive host. The stage begins when the newly excysted juveniles migrate through the liver parenchyma where they increase in size to become juvenile flukes. From here they migrate into the bile ducts, where they grow and develop into fully mature adults.
A dormant Digenean (fluke) life stage which occurs after cercariae are released from the intermediate snail host and encyst on vegetation until they are ingested by the definitive host.
OBSOLETE. An adult life-stage of a soil-transmitted nematode such as Trichuris sp. that resides in the intestinal epitheium. The stage ends when the posterior of the male and female worms emerge free into the intestinal lumen at which point the worm enters the lumenal stage.
This term was made obsolete because this is an anotomical part and not a life-stage.
obsolete nematode adult intestinal stage
OBSOLETE. An adult life-stage of a soil-transmitted nematode such as Trichuris sp. in which the anterior portion (whip-like end) is threaded into the tissue mucosa and the posterior of the male and female worms emerges free into the intestinal lumen to facilitate feeding, mating, and subsequent egg deposition.
A tailless cercarium of Schistosoma sp, 3 hours post-infection by skin penetration of the definitive host.
A tailless cercarium of Schistosoma sp, 24 hours post-infection by skin penetration of the definitive host.
The stage that develops from the embyro and is released from the adult female worm, within the mammalian host. Microfilariae are unsheathed and are mainly found in nodules, the skin and connective tissues.
Onchocerca microfilaria (mammalian stage)
Microfilariae that have been ingested by the vector in a blood meal from a mammalian host. Found in the midgut and muscles of the insect host.
Adult female Strongyloides living entirely outside of a host or vector organism.
L1 larvae that develop from the microfilariae in the arthropod vector.
L2 larvae that develops from the L1 larvae in the arthropod vector.
L3 larvae that develop from the L2 larvae in the arthropod vector. This stage is infectious to the mammalian host once it has migrated to the insect proboscis.
L3 larvae after introduction to the mammalian host through the bite wound of the insect vector.
L3 larvae isolated from the insect vector and cultured in vitro for 1 day.
Onchocerca L3 larva in vitro cultured D1
L3 larvae isolated from the insect vector and cultured in vitro for 2 days.
Onchocerca L3 larva in vitro cultured D2
L3 larvae isolated from the insect vector and cultured in vitro for 3 days.
Onchocerca L3 larva in vitro cultured D3
L4 larvae that develop from L3 larvae in the mammalian host.
Larvae isolated from the insect vector and cultured in vitro to the L4 stage.
Adult male that has developed from L4 larvae in the mammalian host.
Adult female that has developed from L4 larvae in the mammalian host.
Any developmental stage of a nematode of the Onchocerca genus.
Adult male Strongyloides living entirely outside of a host or vector organism.
Strongyloides L1 larval stage that is the progeny of free-living adult worms as a part of a of free-living life-cycle.
Strongyloides L1 larval stage that is the progeny of a parasitic adult female as a part of a of parasitic life-cycle.
Strongyloides infective L3 stage that develops from a parasitic adult female as part of a parasitic life-cycle.
Strongyloides infective L3 stage that develops from free-living adult worms as part of a free-living life-cycle.
At 20 Centigrade: 11-12 days after L4-adult molt. 14-15 days after first cleavage.
At 20 Centigrade: 12-13 days after L4-adult molt. 15-16 days after first cleavage.
At 20 Centigrade: 13-14 days after L4-adult molt. 16-17 days after first cleavage.
At 20 Centigrade: 14-15 days after L4-adult molt. 17-18 days after first cleavage.
The stage that begins right after hatching and before development proceeds after feeding. A newly hatched L1 larva contains 558 cells.
The stage in which first stage larvae (L1) that hatch in the absence of food enter a state of developmental arrest.
A C. elegans life stage that occurs during embryogenesis
C. elegans life stage occurring during embryogenesis
A C. elegans life stage that occurs after embryogenesis
C. elegans life stage occurring post embryogenesis
A C. elegans life stage that occurs during the elongating embryo life stage
C. elegans life stage occurring during elongating embryo
A C. elegans life stage that occurs during the 1.5-fold embryo life stage
C. elegans life stage occurring during 1.5-fold embryo
A C. elegans life stage that occurs during the 2-fold embryo life stage
C. elegans life stage occurring during 2-fold embryo
A C. elegans life stage that occurs during the 3-fold embryo life stage
C. elegans life stage occurring during 3-fold embryo
A C. elegans life stage that occurs during the bean embryo life stage
C. elegans life stage occurring during bean embryo
A C. elegans life stage that occurs during the comma embryo life stage
C. elegans life stage occurring during comma embryo
A C. elegans life stage that occurs during the fully-elongating embryo life stage
C. elegans life stage occurring during fully-elongated embryo
A C. elegans life stage that occurs during the proliferating embryo life stage
C. elegans life stage occurring during proliferating embryo
A C. elegans life stage that occurs during the blastula embryo life stage
C. elegans life stage occurring during blastula embryo
A C. elegans life stage that occurs during the gastrulating embryo life stage
C. elegans life stage occurring during gastrulation
A C. elegans life stage that occurs during the enclosing embryo life stage
C. elegans life stage occurring during enclosing embryo
A C. elegans life stage that occurs during the adult life stage
C. elegans life stage occurring during adulthood
A C. elegans life stage that occurs during the larval life stage
C. elegans life stage occurring during larval stage
A C. elegans life stage that occurs during the L1 larval life stage
C. elegans life stage occurring during L1 larval stage
A C. elegans life stage that occurs during the L2 larval life stage
C. elegans life stage occurring during L2 larval stage
A C. elegans life stage that occurs during the L3 larval life stage
C. elegans life stage occurring during L3 larval stage
A C. elegans life stage that occurs during the L4 larval life stage
C. elegans life stage occurring during L4 larval stage
A C. elegans life stage classified by the number of minutes post first embryonic cleavage.
C. elegans life stage by minutes post first cleavage
C. elegans life stage classified by the number of cells in the organism.
C. elegans life stage by number of cells
C. elegans life stage that occurs during a larval molt
C. elegans life stage occurring during larval molt
A life stage of the nematode Caenorhabditis elegans
C. elegans life stage
OSBSOLETE: A set of life stages of the nematode Caenorhabditis elegans
obsolete set of worm life stages
A C. elegans life stage that occurs after the animal has recovered from the dauer diapause. This includes the post dauer L3 (PDL3) stage, the post dauer L4 (PDL4) stage, and post dauer adult stage.
post dauer stage Ce
A C. elegans L4 larval life stage that occurs after the animal has recovered from the dauer diapause.
"Larvae molt from PDL3 to the PDL4 stage approximately 16 hours after stimulation to recover from dauer at 20 degrees Celsius, or 12 hours after stimulation to recover at 25 degrees Celsius (Figure 3) (Cassada and Russell, 1975; Reape and Burnell,1990). PDL4 larvae are morphologically indistinguishable from L4 larvae, at least at the gross level. Similarly, PDadults appear identical to adults that developed continuously. However, subtle differences do exist. For example,some changes in muscle arm and neuronal cell structure persist in post-dauer stages (Dixon et al., 2008; Schroeder et al., 2013). Interestingly, this apparent similarity between post-dauer and continuously developed animals belies a number of changes at the level of expression of protein coding and small RNA coding genes, as well as changes in chromatin structure (Hall et al., 2010; Karp et al., 2011; Hall et al., 2013)."
post dauer L4 stage Ce
A C. elegans adult life stage that occurs after the animal has recovered from the dauer diapause.
post dauer adult stage Ce
Western Australian Mulga Shrublands Ecoregion
Australasia Ecoregion
Southern central Australia Ecoregion
Simpson Desert Region
Pilbara Shrublands Ecoregion
Carnarvon Xeric Shrublands Ecoregion
Central Ranges Xeric Shrub Ecoregion
Gibson Desert Ecoregion
The Great Sandy-Tanami Desert Ecoregion
Great Victoria Desert Ecoregion
Nullarbor Plains Xeric Shrubland Ecoregion
Afrotropical Ecoregion
Southern Africa: Southern Namibia into South Africa
Succulent Karoo Ecoregion
Arabian Peninsula: Yemen and Saudi Arabia
Yemen and Saudi Arabia Ecoregion
Arabian Peninsula: Yemen, Saudi Arabia, and Oman
Yemen, Saudi Arabia, and Oman Ecoregion
Somali montane xeric woodlands ecoregion
Somali Montane Xeric Woodland Ecoregion
Islands east of the Horn of Africa and south of Yemen Ecoregion
Socotran Archipelago Ecoregion
Red Sea Coastal Desert Ecoregion
Namibian Savanna Woodland Ecoregion
Namib Desert Ecoregion
Nama Karoo Ecoregion
Masai Xeric Grasslands and Shrublands Ecoregion
Madagascar Succulent Woodlands Ecoregion
Madagascar Spiny Thickets Ecoregion
Africa: Coastal Namibia and Angola Ecoregion
Kaokoveld Desert Ecoregion
Kalahari Xeric Savanna Ecoregion
Southern Africa: Islands about half-way between southern Madagascar and southern Mozambique Ecoregion
Ile Europa and Bassas da India Ecoregion
Hobyo Grassland and Shrubland Ecoregion
Arabian Peninsula: Oman and United Arab Emirates Ecoregion
Oman and United Arab Emirates Ecoregion
Ethiopian Xeric Grasslands and Shrublands Ecoregion
Eritrean Coastal Desert Ecoregion
North central Africa: Eastern Chad and small area of western Sudan
East Saharan Montane Xeric Woodland Ecoregion
Western Asia: Oman, Yemen, and Saudi Arabia Ecoregion
Oman, Yemen, and Saudi Arabia Ecoregion
Aldabra Island Xeric Scrub Ecoregion
Indo-Malay Ecoregion
Southern Asia: Western India into Pakistan
Thar Desert
Southern Asia: Eastern India and western Pakistan
Northwestern Thorn Scrub Forests
Solar radiation
example to be eventually removed
metadata complete
Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.
organizational term
The term was created to ease viewing/sorting terms for development purposes, but will not be included in a release.
ready for release
Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."
metadata incomplete
Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.
uncurated
Nothing done yet beyond assigning a unique class ID and proposing a preferred term.
pending final vetting
All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.
to be replaced with external ontology term
Terms with this status should eventually replaced with a term from another ontology.
Alan Ruttenberg
requires discussion
A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z
GP(X)-enables->MF(Y)-has_part->MF(Z) => GP(X) enables MF(Z), e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase coupled transporter activity' has_part 'ATPase activity' then GP(X) enables 'ATPase activity'
GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction'
If a molecular function (X) has a regulatory subfunction, then any gene product which is an input to that subfunction has an activity that directly_regulates X. Note: this is intended for cases where the regaultory subfunction is protein binding, so it could be tightened with an additional clause to specify this.
inferring direct reg edge from input to regulatory subfunction
inferring direct neg reg edge from input to regulatory subfunction
inferring direct positive reg edge from input to regulatory subfunction
effector input is compound function input
Input of effector is input of its parent MF
if effector directly regulates X, its parent MF directly regulates X
if effector directly positively regulates X, its parent MF directly positively regulates X
if effector directly negatively regulates X, its parent MF directly negatively regulates X
'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).
'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties).